WorldWideScience

Sample records for chronological ovarian age

  1. Biological versus chronological ovarian age: implications for assisted reproductive technology

    Directory of Open Access Journals (Sweden)

    Tredway Donald

    2009-09-01

    Full Text Available Abstract Background Women have been able to delay childbearing since effective contraception became available in the 1960s. However, fertility decreases with increasing maternal age. A slow but steady decrease in fertility is observed in women aged between 30 and 35 years, which is followed by an accelerated decline among women aged over 35 years. A combination of delayed childbearing and reduced fecundity with increasing age has resulted in an increased number and proportion of women of greater than or equal to 35 years of age seeking assisted reproductive technology (ART treatment. Methods Literature searches supplemented with the authors' knowledge. Results Despite major advances in medical technology, there is currently no ART treatment strategy that can fully compensate for the natural decline in fertility with increasing female age. Although chronological age is the most important predictor of ovarian response to follicle-stimulating hormone, the rate of reproductive ageing and ovarian sensitivity to gonadotrophins varies considerably among individuals. Both environmental and genetic factors contribute to depletion of the ovarian oocyte pool and reduction in oocyte quality. Thus, biological and chronological ovarian age are not always equivalent. Furthermore, biological age is more important than chronological age in predicting the outcome of ART. As older patients present increasingly for ART treatment, it will become more important to critically assess prognosis, counsel appropriately and optimize treatment strategies. Several genetic markers and biomarkers (such as anti-Müllerian hormone and the antral follicle count are emerging that can identify women with accelerated biological ovarian ageing. Potential strategies for improving ovarian response include the use of luteinizing hormone (LH and growth hormone (GH. When endogenous LH levels are heavily suppressed by gonadotrophin-releasing hormone analogues, LH supplementation may help

  2. Aging in elderly: Chronological versus photoaging

    Directory of Open Access Journals (Sweden)

    Priya Cinna Durai

    2012-01-01

    Full Text Available Background: Skin is a window to aging changes, a biological reality. There is a dearth of studies regarding the various chronological (intrinsic aging and photoaging (extrinsic changes seen in Asians. This study was undertaken to detect the clinical pattern of aging skin changes and dermatoses seen in the elderly. Materials and Methods: This was a descriptive study conducted on 500 consecutive elderly individuals attending the Dermatology out-patient department. The severity of photoaging was graded using Glogau scale. Results: Most of the population had skin type IV and V. Majority (415, 83% of our cases had chronological aging without photoaging and the remaining 85 (17% individuals had photoaging along with chronological aging. The common skin changes due to chronological aging were thin skin, fine wrinkles, xerosis, and loss of elasticity. Photoaging changes such as dyspigmentation, freckles, thick skin, deep wrinkles, melasma, citrine skin, senile purpura, pseudostellate scar, acrokeratoelastoidosis marginalis, and lentigines were less frequent in our study. Smoking and prolonged sun exposure was the risk factors aggravating photoaging. The most common dermatosis was pruritus in 248 (49.6% individuals, of which 149 (29.8% had pruritus associated with xerosis. Contact dermatitis was more common in males. Fungal infections were frequently seen in females. Seborrhoeic keratosis (253, 50.6% was the most common benign neoplasm more commonly seen in males. Cutaneous malignancies were less common in our study population. Conclusion: Photoaging changes were less common than chronological aging changes in skin type IV. Chronological changes were more frequent in females than males, while photoaging was more frequent in males.

  3. Quantifying yeast chronological life span by outgrowth of aged cells.

    Science.gov (United States)

    Murakami, Christopher; Kaeberlein, Matt

    2009-01-01

    The budding yeast Saccharomyces cerevisiae has proven to be an important model organism in the field of aging research. The replicative and chronological life spans are two established paradigms used to study aging in yeast. Replicative aging is defined as the number of daughter cells a single yeast mother cell produces before senescence; chronological aging is defined by the length of time cells can survive in a non-dividing, quiescence-like state. We have developed a high-throughput method for quantitative measurement of chronological life span. This method involves aging the cells in a defined medium under agitation and at constant temperature. At each age-point, a sub-population of cells is removed from the aging culture and inoculated into rich growth medium. A high-resolution growth curve is then obtained for this sub-population of aged cells using a Bioscreen C MBR machine. An algorithm is then applied to determine the relative proportion of viable cells in each sub-population based on the growth kinetics at each age-point. This method requires substantially less time and resources compared to other chronological lifespan assays while maintaining reproducibility and precision. The high-throughput nature of this assay should allow for large-scale genetic and chemical screens to identify novel longevity modifiers for further testing in more complex organisms. PMID:19421136

  4. An Update on Ovarian Aging and Ovarian Reserve Tests

    Directory of Open Access Journals (Sweden)

    Migraci Tosun

    2016-12-01

    Full Text Available Ovaries are the female organs that age more quickly than other tissues such as the uterus, the pituitary gland or pancreas. Different from males, an interesting question is why and how the females lose fertility so rapidly. During the aging process, both the number and quality of the oocytes in the ovaries decrease and reach to a point beyond that no more viable offspring may be produced and the associated cyclic endocrinological activities cease, entering the menopause in females at an average age of 50 years. Females who delayed childbearing with or without their willing until their 30 years or 40 years constitute the largest portion of the total infertility population. Ovarian reserve tests (ORTs provide an indirect estimate of a female�s diminishing ovarian reserve or remaining follicular pool. This article briefly reviews recent progresses in relation to ovarian aging and ORTs.

  5. Chronological ageing of human hair keratin fibres.

    Science.gov (United States)

    Thibaut, S; de Becker, E; Bernard, B A; Huart, M; Fiat, F; Baghdadli, N; Luengo, G S; Leroy, F; Angevin, P; Kermoal, A M; Muller, S; Peron, M; Provot, G; Kravtchenko, S; Saint-Léger, D; Desbois, G; Gauchet, L; Nowbuth, K; Galliano, A; Kempf, J Y; Silberzan, I

    2010-12-01

    Examination of very long hair (length > 2.4 m) using a large range of evaluation methods including physical, chemical, biochemical and microscopic techniques has enabled to attain a detailed understanding of natural ageing of human hair keratin fibres. Scrutinizing hair that has undergone little or no oxidative aggression--because of the absence of action of chemical agents such as bleaching or dyeing--from the root to the tip shows the deterioration process, which gradually takes place from the outside to the inside of the hair shaft: first, a progressive abrasion of the cuticle, whilst the cortex structure remains unaltered, is evidenced along a length of roughly 1 m onwards together with constant shine, hydrophobicity and friction characteristics. Further along the fibre, a significant damage to cuticle scales occurs, which correlates well with ceramides and 18-Methyl Eicosanoic Acid (18-MEA) decline, and progressive decrease in keratin-associated protein content. Most physical descriptors of mechanical and optical properties decay significantly. This detailed description of natural ageing of human hair fibres by a fine analysis of hair components and physical parameters in relationship with cosmetic characteristics provides a time-dependent 'damage scale' of human hair, which may help in designing new targeted hair care formulations. PMID:20384898

  6. Relationships between Chronological Age, Developmental Age, and Standardized Achievement Tests in Kindergarten.

    Science.gov (United States)

    Freberg, Laura

    1991-01-01

    Evaluated chronological age and results of Gesell School Readiness Test as predictors of kindergarten performance as measured by Stanford Achievement Test. Results from 284 kindergarten children indicated that both chronological and developmental age provided good predictors of Stanford Achievement Test performance in kindergarten. Findings have…

  7. Molecular biomarkers for chronological age in animal ecology.

    Science.gov (United States)

    Jarman, Simon N; Polanowski, Andrea M; Faux, Cassandra E; Robbins, Jooke; De Paoli-Iseppi, Ricardo; Bravington, Mark; Deagle, Bruce E

    2015-10-01

    The chronological age of an individual animal predicts many of its biological characteristics, and these in turn influence population-level ecological processes. Animal age information can therefore be valuable in ecological research, but many species have no external features that allow age to be reliably determined. Molecular age biomarkers provide a potential solution to this problem. Research in this area of molecular ecology has so far focused on a limited range of age biomarkers. The most commonly tested molecular age biomarker is change in average telomere length, which predicts age well in a small number of species and tissues, but performs poorly in many other situations. Epigenetic regulation of gene expression has recently been shown to cause age-related modifications to DNA and to cause changes in abundance of several RNA types throughout animal lifespans. Age biomarkers based on these epigenetic changes, and other new DNA-based assays, have already been applied to model organisms, humans and a limited number of wild animals. There is clear potential to apply these marker types more widely in ecological studies. For many species, these new approaches will produce age estimates where this was previously impractical. They will also enable age information to be gathered in cross-sectional studies and expand the range of demographic characteristics that can be quantified with molecular methods. We describe the range of molecular age biomarkers that have been investigated to date and suggest approaches for developing the newer marker types as age assays in nonmodel animal species.

  8. Ovarian Aging : Mechanisms and Clinical Consequences

    NARCIS (Netherlands)

    Broekmans, F. J.; Soules, M. R.; Fauser, B. C.

    2009-01-01

    Menopause is the final step in the process referred to as ovarian ageing. The age related decrease in follicle numbers dictates the onset of cycle irregularity and the final cessation of menses. The parallel decay in oocyte quality contributes to the gradual decline in fertility and the final occurr

  9. Chronological aging in conidia of pathogenic Aspergillus: Comparison between species.

    Science.gov (United States)

    Oliveira, Manuela; Pereira, Clara; Bessa, Cláudia; Araujo, Ricardo; Saraiva, Lucília

    2015-11-01

    Aspergillus fumigatus, Aspergillus flavus, Aspergillus terreus and Aspergillus niger are common airborne fungi, and the most frequent causative agents of human fungal infections. However, the resistance and lifetime persistence of these fungi in the atmosphere, and the mechanism of aging of Aspergillus conidia are unknown.With this work, we intended to study the processes underlying conidial aging of these four relevant and pathogenic Aspergillus species. Chronological aging was therefore evaluated in A. fumigatus, A. flavus, A. terreus and A. niger conidia exposed to environmental and human body temperatures. The results showed that the aging process in Aspergillus conidia involves apoptosis,with metacaspase activation, DNA fragmentation, and reactive oxygen species production, associated with secondary necrosis. Distinct results were observed for the selected pathogenic species. At environmental conditions, A. niger was the species with the highest resistance to aging, indicating a higher adaption to environmental conditions, whereas A. flavus followed by A. terreus were the most sensitive species. At higher temperatures (37 °C), A. fumigatus presented the longest lifespan, in accordance with its good adaptation to the human body temperature. Altogether,with this work new insights regarding conidia aging are provided, which may be useful when designing treatments for aspergillosis.

  10. Aging on a different scale - chronological versus pathology-related aging.

    OpenAIRE

    Melis, J.P.; Jonker, M.J.; Vijg, J.; Hoeijmakers, J. H.; Breit, T.M.; Steeg, van der, A.F.W.

    2013-01-01

    In the next decades the elderly population will increase dramatically, demanding appropriate solutions in health care and aging research focusing on healthy aging to prevent high burdens and costs in health care. For this, research targeting tissue-specific and individual aging is paramount to make the necessary progression in aging research. In a recently published study we have attempted to make a step interpreting aging data on chronological as well as pathological scale. For this, we samp...

  11. Third-molar development in relation to chronologic age in young adults of central China.

    Science.gov (United States)

    Bai, Yuming; Mao, Jing; Zhu, Shengrong; Wei, Wei

    2008-08-01

    The estimation of chronologic age based on the stages of third-molar development was evaluated by using the eight stages (A-H) method of Demirjian and the third-molar development was compared, in terms of sex and age, with results of previous studies. The samples consisted of 291 orthopantomograms from young Chinese subjects of known chronologic age and sex (including 139 males with a mean age of 14.67+/-3.62 y and 152 females with a mean age of 14.85+/-3.70 y). Statistical analysis was performed by employing the Mann-Whitney U-test and the t-test. Regression analysis was conducted to obtain regression formulas for calculating dental age from the chronologic age. Our results showed statistically significant differences (Pthird-molar development between males and females, at the calcification stages D, E and H. And a strong correlation was found between age and third-molar development in both males (r (2)=0.65) and females (r (2)=0.61). New equations (Age=8.76+1.32 Development stage) for estimating chronologic age were derived. It is concluded that third-molar genesis took place earlier in males than in females. The use of third molars as a developmental marker is appropriate in young adults of Central China. The formula obtained in the present study can be used as a guide for estimation of dental maturity and a standard for age estimation for young adults of Central China.

  12. The epigenetic clock and telomere length are independently associated with chronological age and mortality

    Science.gov (United States)

    Marioni, Riccardo E; Harris, Sarah E; Shah, Sonia; McRae, Allan F; von Zglinicki, Thomas; Martin-Ruiz, Carmen; Wray, Naomi R; Visscher, Peter M; Deary, Ian J

    2016-01-01

    Background: Telomere length and DNA methylation have been proposed as biological clock measures that track chronological age. Whether they change in tandem, or contribute independently to the prediction of chronological age, is not known. Methods: We address these points using data from two Scottish cohorts: the Lothian Birth Cohorts of 1921 (LBC1921) and 1936 (LBC1936). Telomere length and epigenetic clock estimates from DNA methylation were measured in 920 LBC1936 participants (ages 70, 73 and 76 years) and in 414 LBC1921 participants (ages 79, 87 and 90 years). Results: The epigenetic clock changed over time at roughly the same rate as chronological age in both cohorts. Telomere length decreased at 48–67 base pairs per year on average. Weak, non-significant correlations were found between epigenetic clock estimates and telomere length. Telomere length explained 6.6% of the variance in age in LBC1921, the epigenetic clock explained 10.0%, and combined they explained 17.3% (all P epigenetic age was linked to a 22% increased mortality risk (P = 2.6 × 10−4) whereas, in the same model, a one standard deviation increase in baseline telomere length was independently linked to an 11% decreased mortality risk (P = 0.06). Conclusions: These results suggest that telomere length and epigenetic clock estimates are independent predictors of chronological age and mortality risk. PMID:27075770

  13. Blood cell mitochondrial DNA content and premature ovarian aging.

    Directory of Open Access Journals (Sweden)

    Marco Bonomi

    Full Text Available Primary ovarian insufficiency (POI is a critical fertility defect characterized by an anticipated and silent impairment of the follicular reserve, but its pathogenesis is largely unexplained. The frequent maternal inheritance of POI together with a remarkable dependence of ovarian folliculogenesis upon mitochondrial biogenesis and bioenergetics suggested the possible involvement of a generalized mitochondrial defect. Here, we verified the existence of a significant correlation between blood and ovarian mitochondrial DNA (mtDNA content in a group of women undergoing ovarian hyperstimulation (OH, and then aimed to verify whether mtDNA content was significantly altered in the blood cells of POI women. We recruited 101 women with an impaired ovarian reserve: 59 women with premature ovarian failure (POF and 42 poor responders (PR to OH. A Taqman copy number assay revealed a significant mtDNA depletion (P<0.001 in both POF and PR women in comparison with 43 women of similar age and intact ovarian reserve, or 53 very old women with a previous physiological menopause. No pathogenic variations in the mitochondrial DNA polymerase γ (POLG gene were detected in 57 POF or PR women with low blood mtDNA content. In conclusion, blood cell mtDNA depletion is a frequent finding among women with premature ovarian aging, suggesting that a still undetermined but generalized mitochondrial defect may frequently predispose to POI which could then be considered a form of anticipated aging in which the ovarian defect may represent the first manifestation. The determination of mtDNA content in blood may become an useful tool for the POI risk prediction.

  14. Perceived Changes in Well-Being: The Role of Chronological Age, Target Age, and Type of Measure

    Science.gov (United States)

    Okun, Morris A.; Dittburner, Julie L.; Huff, Barbara P.

    2006-01-01

    The goal of this study is to investigate whether perceived changes in one's well-being from the present to the future are related to chronological age, target age, and type of measure (psychological well-being versus life satisfaction). Young adults (N = 114) rated their current well-being and their future well-being at one of three target ages…

  15. Chronological and subjective age differences in flourishing mental health and major depressive episode.

    NARCIS (Netherlands)

    Keyes, C.L.M.; Westerhof, G.J.

    2012-01-01

    Mental health is more than the absence of psychopathology, but few studies use positive mental health along with a measure of past year major depressive episode (MDE). This study addresses this gap by investigating the association of MDE and flourishing mental health (FMH) with chronological age and

  16. The effects of chronological age and size on toxicity of zinc to juvenile brown trout

    Science.gov (United States)

    A series of toxicity tests were conducted to investigate the role of chronological age and organism weight on zinc tolerance in juvenile brown trout (Salmo trutta). Four different incubation temperatures were used to control the maturation of the juveniles prior to zinc exposure...

  17. Third-Molar Development in Relation to Chronologic Age in Young Adults of Central China

    Institute of Scientific and Technical Information of China (English)

    Yuming BAI; Jing MAO; Shengrong ZHU; Wei WEI

    2008-01-01

    The estimation of chronologic age based on the stages of third-molar development was evaluated by using the eight stages (A-H) method of Demirjian and the third-molar development was compared, in terms of sex and age, with results of previous studies. The samples consisted of 291orthopantomograms from young Chinese subjects of known chronologic age and sex (including 139males with a mean age of 14.67±3.62 y and 152 females with a mean age of 14.85±3.70 y). Statistical analysis was performed by employing the Mann-Whitney U-test and the t-test. Regression analysis was conducted to obtain regression formulas for calculating dental age from the chronologic age. Our results showed statistically significant differences (P<0.05) in third-molar development between males and females, at the calcification stages D, E and H. And a strong correlation was found between age and third-molar development in both males (r2=0.65) and females (r2=0.61). New equations (Age=8.76+1.32 Development stage) for estimating chronologic age were derived. It is concluded that third-molar genesis took place earlier in males than in females. The use of third molars as a developmental marker is appropriate in young adults of Central China. The formula obtained in the present study can be used as a guide for estimation of dental maturity and a standard for age estimation for young adults of Central China.

  18. 14C dates from Tel Rehov: Iron-Age chronology, pharaohs, and Hebrew kings.

    Science.gov (United States)

    Bruins, Hendrik J; van der Plicht, Johannes; Mazar, Amihai

    2003-04-11

    Stratified radiocarbon dates provide an independent chronological link between archaeological layers and historical data. The invasion by Pharaoh Shoshenq I (Shishak) is a key historical synchronism, approximately 925 B.C.E., mentioned in both Egyptian inscriptions and the Hebrew Bible. The list of places raided by Shoshenq, mentioned at Karnak (Egypt), includes Rehov (Israel). The site yielded a consistent series of radiocarbon dates from the 12th to 9th century B.C.E. Our results (i) suggest a revised Iron-Age chronology; (ii) date an archaeological stratum to Shoshenq's campaign; (iii) indicate the similarity of "Solomonic" and "Omride" pottery; and (iv) provide correlation with Greece and Cyprus.

  19. Dental and Skeletal Maturity- A Biological Indicator of Chronologic Age

    OpenAIRE

    Rai, Vivek; Saha, Sonali; Yadav, Gunjan; Tripathi, Abhay Mani; Grover, Kavita

    2014-01-01

    Introduction: Precise evaluation of the developmental stage of a child is not only an integral part of both diagnosis and treatment of paediatric patients; it is also essential in Forensic Medicine and Dentistry. Physiologic age can be estimated by somatic, sexual, skeletal and dental maturity.

  20. Absolute ages from crater statistics: Using radiometric ages of Martian samples for determining the Martian cratering chronology

    Science.gov (United States)

    Neukum, G.

    1988-01-01

    In the absence of dates derived from rock samples, impact crater frequencies are commonly used to date Martian surface units. All models for absolute dating rely on the lunar cratering chronology and on the validity of its extrapolation to Martian conditions. Starting from somewhat different lunar chronologies, rather different Martian cratering chronologies are found in the literature. Currently favored models are compared. The differences at old ages are significant, the differences at younger ages are considerable and give absolute ages for the same crater frequencies as different as a factor of 3. The total uncertainty could be much higher, though, since the ratio of lunar to Martian cratering rate which is of basic importance in the models is believed to be known no better than within a factor of 2. Thus, it is of crucial importance for understanding the the evolution of Mars and determining the sequence of events to establish an unambiguous Martian cratering chronology from crater statistics in combination with clean radiometric ages of returned Martian samples. For the dating goal, rocks should be as pristine as possible from a geologically simple area with a one-stage emplacement history of the local formation. A minimum of at least one highland site for old ages, two intermediate-aged sites, and one very young site is needed.

  1. Evaluation of third molar development in the estimation of chronological age.

    Science.gov (United States)

    Soares, Caio Belém Rodrigues Barros; Figueiroa, José Natal; Dantas, Renata Moura Xavier; Kurita, Lúcio Mitsuo; Pontual, Andréa dos Anjos; Ramos-Perez, Flávia Maria de Moraes; Perez, Danyel Elias da Cruz; Pontual, Maria Luiza dos Anjos

    2015-09-01

    The purpose of this study was to evaluate the correlation between chronological age and the degree of third molar mineralization by Demirjian's developmental stages (Demirjian et al., 1973) using panoramic radiography. From a total of 11.396 digital panoramic radiographs of patients from three oral radiology private clinics from the northeast region of Brazil, obtained from January to June 2009, 2097 radiographic images from patients aged between 6 and 22 years were selected. The images were analyzed individually by two obsevers using a 21-inch computer screen and Windows Picture and Fax Viewer. Reliability was achieved by intra- and interobserver evaluation, using the Kappa test. Chronological age, calcification stage, gender and third molar were interrelated using a multiple linear regression model, considering age as a response variable. There was reliability with Demirjian et al.'s developmental stage assesment, displaying a significant relationship between mineralization stages and patients' age (Page and the calcification stage taking gender and localization of the third molar into consideration. It is possible to estimate chronological age based on Demirjian's stage of a third molar, regardless of gender and location.

  2. Gross Motor Coincidence Timing by Children with Learning Difficulties and Children Matched on Mean Chronological and Mental Age.

    Science.gov (United States)

    Jacklin, Susan M.

    1987-01-01

    This study examines the learning of a gross motor coincidence timing task by children with learning difficulties, compared with that by children of average intelligence of an equivalent chronological age and mental age. Results are discussed. (Author/MT)

  3. Rewriting the Central European Early Bronze Age Chronology: Evidence from Large-Scale Radiocarbon Dating.

    Directory of Open Access Journals (Sweden)

    Philipp W Stockhammer

    Full Text Available The transition from the Neolithic to the Early Bronze Age in Central Europe has often been considered as a supra-regional uniform process, which led to the growing mastery of the new bronze technology. Since the 1920s, archaeologists have divided the Early Bronze Age into two chronological phases (Bronze A1 and A2, which were also seen as stages of technical progress. On the basis of the early radiocarbon dates from the cemetery of Singen, southern Germany, the beginning of the Early Bronze Age in Central Europe was originally dated around 2300/2200 BC and the transition to more complex casting techniques (i.e., Bronze A2 around 2000 BC. On the basis of 140 newly radiocarbon dated human remains from Final Neolithic, Early and Middle Bronze Age cemeteries south of Augsburg (Bavaria and a re-dating of ten graves from the cemetery of Singen, we propose a significantly different dating range, which forces us to re-think the traditional relative and absolute chronologies as well as the narrative of technical development. We are now able to date the beginning of the Early Bronze Age to around 2150 BC and its end to around 1700 BC. Moreover, there is no transition between Bronze (Bz A1 and Bronze (Bz A2, but a complete overlap between the type objects of the two phases from 1900-1700 BC. We thus present a revised chronology of the assumed diagnostic type objects of the Early Bronze Age and recommend a radiocarbon-based view on the development of the material culture. Finally, we propose that the traditional phases Bz A1 and Bz A2 do not represent a chronological sequence, but regionally different social phenomena connected to the willingness of local actors to appropriate the new bronze technology.

  4. PATTERN OF OVARIAN TUMORS AND THEIR AGE DISTRIBUTION IN KANGRA VALLEY , HIMACHAL PRADESH

    OpenAIRE

    Mani

    2015-01-01

    A female’s risk at birth of having ovarian tumors in her lifetime is 6 - 7%. Relative frequency of ovarian tumor is different for western and Asian countries. Two third of ovarian tumors occur in women of reproductive age group. This study is done in Dr. RPGMC and Hospital with the aim to find out frequency o f different histological types of ovarian tumors and their age distribution in Kangra valley. One hundred forty eight ovarian tumors , reported were include...

  5. A microarray-based genetic screen for yeast chronological aging factors.

    Directory of Open Access Journals (Sweden)

    Mirela Matecic

    2010-04-01

    Full Text Available Model organisms have played an important role in the elucidation of multiple genes and cellular processes that regulate aging. In this study we utilized the budding yeast, Saccharomyces cerevisiae, in a large-scale screen for genes that function in the regulation of chronological lifespan, which is defined by the number of days that non-dividing cells remain viable. A pooled collection of viable haploid gene deletion mutants, each tagged with unique identifying DNA "bar-code" sequences was chronologically aged in liquid culture. Viable mutants in the aging population were selected at several time points and then detected using a microarray DNA hybridization technique that quantifies abundance of the barcode tags. Multiple short- and long-lived mutants were identified using this approach. Among the confirmed short-lived mutants were those defective for autophagy, indicating a key requirement for the recycling of cellular organelles in longevity. Defects in autophagy also prevented lifespan extension induced by limitation of amino acids in the growth media. Among the confirmed long-lived mutants were those defective in the highly conserved de novo purine biosynthesis pathway (the ADE genes, which ultimately produces IMP and AMP. Blocking this pathway extended lifespan to the same degree as calorie (glucose restriction. A recently discovered cell-extrinsic mechanism of chronological aging involving acetic acid secretion and toxicity was suppressed in a long-lived ade4Delta mutant and exacerbated by a short-lived atg16Delta autophagy mutant. The identification of multiple novel effectors of yeast chronological lifespan will greatly aid in the elucidation of mechanisms that cells and organisms utilize in slowing down the aging process.

  6. Chronological and subjective age differences in flourishing mental health and major depressive episode.

    Science.gov (United States)

    Keyes, Corey L M; Westerhof, Gerben J

    2012-01-01

    Mental health is more than the absence of psychopathology, but few studies use positive mental health along with a measure of past year major depressive episode (MDE). This study addresses this gap by investigating the association of MDE and flourishing mental health (FMH) with chronological age and subjective (felt and ideal) age. Data are from the Midlife in the United States random digit dialing sample of adults ages 25 to 74, collected in 1995 (n = 3032). Rates of MDE were lowest, and FMH highest, among the three oldest age cohorts (45-54, 55-64, 65-74 years). Subjective age was linked with chronological age; with age, adults tend to feel younger, and want to be an age that is younger, than their actual age. As predicted by the model of subjective age as an adaptive strategy, feeling younger was related to a lower risk of MDE and a higher risk of FMH. However, wanting to be younger was related to a lower risk of FMH and unrelated to MDE. PMID:21780972

  7. Chronology for the Aegean Late Bronze Age 1700-1400 B.C.

    Science.gov (United States)

    Manning, Sturt W; Ramsey, Christopher Bronk; Kutschera, Walter; Higham, Thomas; Kromer, Bernd; Steier, Peter; Wild, Eva M

    2006-04-28

    Radiocarbon (carbon-14) data from the Aegean Bronze Age 1700-1400 B.C. show that the Santorini (Thera) eruption must have occurred in the late 17th century B.C. By using carbon-14 dates from the surrounding region, cultural phases, and Bayesian statistical analysis, we established a chronology for the initial Aegean Late Bronze Age cultural phases (Late Minoan IA, IB, and II). This chronology contrasts with conventional archaeological dates and cultural synthesis: stretching out the Late Minoan IA, IB, and II phases by approximately 100 years and requiring reassessment of standard interpretations of associations between the Egyptian and Near Eastern historical dates and phases and those in the Aegean and Cyprus in the mid-second millennium B.C. PMID:16645092

  8. The chronology of Castelo de Castro Marim. An Iron Age settlement

    Directory of Open Access Journals (Sweden)

    Ana Margarida Arruda

    2014-01-01

    Full Text Available The Iron Age diachrony of Castro Marim occupation has been established with the stratigraphic sequence and the materials recovered in the different levels. Based on these data we have already presented chronological proposals for the four phases, which we could also characterize in relation with architectural plans and with the archaeological materials. The collection of organic material at all levels of the stratigraphic sequence allowed us to obtain absolute dates, carried out on shells and charcoals. In this work, the data from the radiocarbon chronology are presented and discussed by themselves and related with the others. The relationship between the 14C dates and those obtained by morphological analysis of the materials collected along the stratigraphic sequence bring more solid bases to analyze the diachronic evolution of Castro Marim Iron Age.

  9. Discrimination of speech sounds by children with dyslexia: comparisons with chronological age and reading level controls.

    Science.gov (United States)

    Bogliotti, C; Serniclaes, W; Messaoud-Galusi, S; Sprenger-Charolles, L

    2008-10-01

    Previous studies have shown that children suffering from developmental dyslexia have a deficit in categorical perception of speech sounds. The aim of the current study was to better understand the nature of this categorical perception deficit. In this study, categorical perception skills of children with dyslexia were compared with those of chronological age and reading level controls. Children identified and discriminated /do-to/ syllables along a voice onset time (VOT) continuum. Results showed that children with dyslexia discriminated among phonemically contrastive pairs less accurately than did chronological age and reading level controls and also showed higher sensitivity in the discrimination of allophonic contrasts. These results suggest that children with dyslexia perceive speech with allophonic units rather than phonemic units. The origin of allophonic perception in the course of perceptual development and its implication for reading acquisition are discussed. PMID:18462745

  10. Chronological age and breed-type effects on carcass characteristics and palatability of bull beef.

    Science.gov (United States)

    Riley, R R; Smith, G C; Cross, H R; Savell, J W; Long, C R; Cartwright, T C

    1986-01-01

    Bulls (n = 115) of four slaughter ages (9, 12, 15 or 18 months) and of 15 genotypes were studied. In this analysis, each bullock was assigned to one of four breed groups-British and British crosses, Brahman and Brahman crosses. Jersey and Jersey crosses or Holstein and Holstein crosses. Slaughter age had an (P Brahman-type bulls had higher shear force values (P Brahman-type carcasses were assigned the lowest numerical ratings for juiciness. Breed-type had a greater effect on tenderness of bull beef than did chronological age.

  11. Bomb carbon in the yelloweye rockfish, Sebastes ruberrimus, as a chronological benchmark for age validation of commercially important fishes

    OpenAIRE

    Kerr, Lisa A.; Andrews, Allen H.; Frantz, Brian R.; Coale, Kenneth H.; Brown, Thomas A.; Gregor M Cailliet

    2004-01-01

    The overall goals of this study were to (1) establish a chronological benchmark for bomb radiocarbon in the waters of southeast Alaska by determining radiocarbon levels in otoliths of the yelloweye rockfish (Sebastes ruberrimus), for which age was validated, (2) validate the age of quillback rockfish (S. maliger), bocaccio rockfish (S. paucispinis), cowcod (S. levis), and canary rockfish (S. pinniger) using the yelloweye rockfish radiocarbon chronology, (3) provide a basis for future age and ...

  12. Profiling IgG N-glycans as potential biomarker of chronological and biological ages

    Science.gov (United States)

    Yu, Xinwei; Wang, Youxin; Kristic, Jasminka; Dong, Jing; Chu, Xi; Ge, Siqi; Wang, Hao; Fang, Honghong; Gao, Qing; Liu, Di; Zhao, Zhongyao; Peng, Hongli; Pucic Bakovic, Maja; Wu, Lijuan; Song, Manshu; Rudan, Igor; Campbell, Harry; Lauc, Gordan; Wang, Wei

    2016-01-01

    Abstract As an important post-translation modifying process, glycosylation significantly affects the structure and function of immunoglobulin G (IgG) molecules and is essential in many steps of the inflammatory cascade. Studies have demonstrated the potential of using glycosylation features of IgG as a component of predictive biomarkers for chronological age in several European populations, whereas no study has been reported in Chinese. Herein, we report various patterns of changes in IgG glycosylation associated with age by analyzing IgG glycosylation in 701 community-based Han Chinese (244 males, 457 females; 23–68 years old). Eleven IgG glycans, including FA2B, A2G1, FA2[6]G1, FA2[3]G1, FA2[6]BG1, FA2[3]BG1, A2G2, A2BG2, FA2G2, FA2G2S1, and FA2G2S2, change considerably with age and specific combinations of these glycan features can explain 23.3% to 45.4% of the variance in chronological age in this population. This indicates that these combinations of glycan features provide more predictive information than other single markers of biological age such as telomere length. In addition, the clinical traits such as fasting plasma glucose and aspartate aminotransferase associated with biological age are strongly correlated with the combined glycan features. We conclude that IgG glycosylation appears to correlate with both chronological and biological ages, and thus its possible role in the aging process merits further study. PMID:27428197

  13. The chronology of second molar development in Brazilians and its application to forensic age estimation

    International Nuclear Information System (INIS)

    This study investigated the possible correlation between the mineralization of the second molars and the chronological age of a sample population of the state of Paraiba, Brazil. One thousand eight hundred fifty-four digitized panoramic images using a scanner of a private dental radiology service were obtained in six months. Of these, 457 were selected from patients aged 4.6 to 16 years who met certain criteria. The images were assessed twice by a radiologist with 5 years experience. A minimum interval of 30 days between the evaluations of the same patient was established. To analyze the relationship between chronological age, calcification level proposed by Demirjian et al in 1973, gender, and tooth, a multiple linear regression model was adjusted, taking age as the response variable (p<0.05). The gender and calcification level were significantly correlated with the age of the patients (p<0.05). There was a significant difference between the average age of the patients' upper teeth compared to the lower ones in both genders (p<0.05). The dental development occurred earlier in female individuals than in male ones, and there was no significant difference between the right and left second permanent molars. It was observed that ethnic variables are related to certain parameters of age and sex identification in the Brazilian population, providing important information for forensic evaluations.

  14. The chronology of second molar development in Brazilians and its application to forensic age estimation

    Energy Technology Data Exchange (ETDEWEB)

    Almeida, Manuella; Santos Carneiro; Beltraeo, Rejane Targino; Beltraeo, Ricardo Villar [School of Dentistry, Federal University of Paraiba, Joaeo Pessoa (Brazil); Pontual, Andrea dos Anjos [Pernambuco Dental School, Pernambuco University-UPE, Camaragibe (Brazil); Pontual, Maria Luiza dos Anjos [Federal University of Pernambuco, Recife (Brazil)

    2013-03-15

    This study investigated the possible correlation between the mineralization of the second molars and the chronological age of a sample population of the state of Paraiba, Brazil. One thousand eight hundred fifty-four digitized panoramic images using a scanner of a private dental radiology service were obtained in six months. Of these, 457 were selected from patients aged 4.6 to 16 years who met certain criteria. The images were assessed twice by a radiologist with 5 years experience. A minimum interval of 30 days between the evaluations of the same patient was established. To analyze the relationship between chronological age, calcification level proposed by Demirjian et al in 1973, gender, and tooth, a multiple linear regression model was adjusted, taking age as the response variable (p<0.05). The gender and calcification level were significantly correlated with the age of the patients (p<0.05). There was a significant difference between the average age of the patients' upper teeth compared to the lower ones in both genders (p<0.05). The dental development occurred earlier in female individuals than in male ones, and there was no significant difference between the right and left second permanent molars. It was observed that ethnic variables are related to certain parameters of age and sex identification in the Brazilian population, providing important information for forensic evaluations.

  15. HISTOPATHOLOGICAL STUDY OF OVARIAN TUMORS IN PAEDIATRIC AGE GROUP

    Directory of Open Access Journals (Sweden)

    Ramani

    2013-06-01

    Full Text Available ABSTRACT: Ovarian tumors are r are in children and constitute 1% of all childhood malignancies and 8% of abdominal tumors. Large cysts and those complicated by torsion make their presence clear by their symptomatology. However, ovarian pathology is still mostly discovered at laparotomy for presumptive appendicitis. Accurate diagnosis of these tumors at such a young age is a great challenge to surgeons and pathologists. This article reviews the clinical presentation, radiological imaging, gross and histopathological findings at the Pathol ogy Department of a Paediatric Referral centre in Hyderabad

  16. An evaluation of third molar eruption for assessment of chronologic age: A panoramic study

    Directory of Open Access Journals (Sweden)

    Monica Tuteja

    2012-01-01

    Full Text Available Objectives: The identity of a person can be established by assessing one′s age, and in order to be entitled to civil rights and social benefits, verification of the chronological age is required and thereby age estimation has gained an increasing significance in recent years. Tooth eruption is one of the criteria of developmental morphology that can be evaluated by either clinical examination or by evaluation of dental radiographs to determine the dental age. The present study was aimed to evaluate the reliability of the third molar eruption stage as a parameter for forensic age estimation in living subjects. Materials and Methods: The stage of wisdom tooth eruption in 77 male and 73 female Indian subjects aged between 12-26 years was determined by subjecting them to conventional orthopantomograms and was interpreted to assess the third molar eruption stages to evaluate the dental age. Results: Predicted minimum age and mean age of the study sample were found to be significant predictors (P<0.001 of actual age. Minimum age was able to explain 58.3% of the variation in actual age and the mean age was able to explain 60.3% of variation in actual age. Conclusion: Third molar is fairly a reliable indicator to determine the age of alveolar, gingival, and complete emergence of third molar in the occlusal plane in adolescents and young adults. Minimum and most probable ages of examined subjects can also be evaluated using third molar eruption stage.

  17. Chronological age and breed-type effects on carcass characteristics and palatability of bull beef.

    Science.gov (United States)

    Riley, R R; Smith, G C; Cross, H R; Savell, J W; Long, C R; Cartwright, T C

    1986-01-01

    Bulls (n = 115) of four slaughter ages (9, 12, 15 or 18 months) and of 15 genotypes were studied. In this analysis, each bullock was assigned to one of four breed groups-British and British crosses, Brahman and Brahman crosses. Jersey and Jersey crosses or Holstein and Holstein crosses. Slaughter age had an (P carcasses with the thickest subcutaneous fat, the highest marbling score and the highest USDA quality grade while Jersey and Jersey cross bullocks yielded carcasses with the lowest weight, smallest longissimus muscle area and the lowest USDA quality grade of the four breed-type groups. Increases in chronological age (from 9 to 18 months) were generally associated with a decrease in USDA maturity score, and increases in marbling score, USDA quality grade, longissimus muscle area, subcutaneous fat thickness and USDA yield grade. Shear force values decreased as bulls matured from 9 to 18 months of age. The meat from Brahman-type bulls had higher shear force values (P carcasses received the highest numerical ratings for sustained juiciness and flavor while steaks from the Brahman-type carcasses were assigned the lowest numerical ratings for juiciness. Breed-type had a greater effect on tenderness of bull beef than did chronological age.

  18. Chronological age estimation of third molar mineralization of Han in southern China.

    Science.gov (United States)

    Zeng, Dong Lin; Wu, Zhi Ling; Cui, Min Yi

    2010-03-01

    In order to study the chronology of age of third molar mineralization of Han in southern China, Demirjian staging method was used to determine the stage of four third molars (18, 28, 38, 48) mineralization in 3,100 Han in southern China aged 4.1-26.9 years based on radiological evidence from digital orthopantomograms. The mean age of the 3,100 patients was 15.96 +/- 4.73 years, including 1,200 male (mean age, 15.32 +/- 4.62) and 1,900 female (mean age, 16.35 +/- 4.76). Results show that there was no significant difference in mineralization between 18 and 28 and 38 and 48 of male or female. However, significant difference was observed between 28 and 38 of female at stage C; 28 was 0.25 years earlier than 38. In male, at stage G, 38 was 0.61 years earlier than 28, and 48 was 0.62 years earlier than 18. At stages D, E, F, G, and H, male 48 was 0.34, 0.66, 0.72, 1.34, and 0.76 years earlier than that of female, respectively. At stages A, D, E, F, G, and H, male 38 was 0.73, 0.26, 0.56, 0.91, 1.29, and 0.70 years earlier than that of female, respectively. At stages B, E, F, G, and H, the mineralization mean age of male 18 was 0.54, 0.50, 0.76, 0.92, and 0.58 years earlier than that of female, respectively. At stages E, F, G, and H, the mineralization mean age of male 28 was 0.51, 0.76, 0.92, and 0.49 years earlier than that of female, respectively. After reviewing the literature, the chronological mineralization age of 48, at stages D to G, of Han in southern China was 1 to 4.6 years earlier than that of Japanese and 1 to 3 years earlier than that of German. The mean age at stage H of 48 of Han in southern China was similar to Turkish, Black African, Japanese, and German, but was later than Spanish. Finally, the conclusions are: (1) in the same gender group of Han in southern China, the mineralization ages between two sides in upper or lower jaw are very similar, and (2) the chronology mean age and complete time of third molar mineralization of male were earlier than

  19. Mineralization of mandibular third molars can estimate chronological age--Brazilian indices.

    Science.gov (United States)

    de Oliveira, Fernando Toledo; Capelozza, Ana Lúcia Álvares; Lauris, José Roberto Pereira; de Bullen, Izabel Regina Fischer Rubira

    2012-06-10

    Forensic age estimation is an important element of anthropological research, as it produces one of the primary sources of data that researchers use to establish the identity of a person living or the identity of unknown bodily remains. The aim of this study was to determine if the chronology of third molar mineralization could be an accurate indicator of estimated age in a sample Brazilian population. If so, mineralization could determine the probability of an individual being 18 years or older. The study evaluated 407 panoramic radiographs of males and females from the past 5 years in order to assess the mineralization status of the mandibular third molars. The evaluation was carried out using an adaptation of Demirjian's system. The results indicated a strong correlation between chronological age and the mineralization of the mandibular third molars. The results indicated that modern Brazilian generation tends to demonstrate an earlier mandibular third molar mineralization than older Brazilian generation and people of other nationalities. Males reached developmental stages slightly earlier than females, but statistically significant differences between the sex were not found. The probability that an individual with third molar mineralization stage H had reached an age of 18 years or older was 96.8-98.6% for males and females, respectively.

  20. Chronological age estimation based on third molar development in a Portuguese population.

    Science.gov (United States)

    Caldas, Inês Morais; Júlio, Paula; Simões, Ricardo Jorge; Matos, Eduarda; Afonso, Américo; Magalhães, Teresa

    2011-03-01

    Third molar development was assessed using a sample of 1,131 orthopantomograms from a Portuguese population. The methodology applied was the eight stages (A-H) method described by Demirjian et al. The final sample was made of 739 orthopantomograms, 387 (52.5%) of which belonging to females; age ranged between 6.1 and 22.5 years old (mean age = 14.49, S.D. = 4.37). For each developmental stage, mean age, standard deviation, and minimal and maximal age was assessed; evaluation of the rate formation of each tooth, according to sex, was calculated and data distribution expressed in percentiles for each stage; the probability of an individual being 16 was also evaluated. The relationship between tooth development and chronological age had a statistical significance for all teeth and both sexes (p thesis that each population need specific data.

  1. Chronological age affects the permeation of fentanyl through human skin in vitro

    DEFF Research Database (Denmark)

    Holmgaard, R; Benfeldt, E; Sorensen, J A;

    2013-01-01

    AIM: To study the influence of chronological age on fentanyl permeation through human skin in vitro using static diffusion cells. Elderly individuals are known to be more sensitive to opioids and obtain higher plasma concentrations following dermal application of fentanyl compared to younger...... individuals. The influence of age - as an isolated pharmacokinetic term - on the absorption of fentanyl has not been previously studied. METHOD: Human skin from 30 female donors was mounted in static diffusion cells, and samples were collected during 48 h. Donors were divided into three age groups: ... and old age groups: 5,922 and 4,050 ng, respectively). Furthermore, the lag time and absorption rate were different between the three groups, with a significantly higher rate in the young participants versus the oldest participants. CONCLUSION: We demonstrate that fentanyl permeates the skin of young...

  2. The chronological age estimation of third molar mineralization of Han population in southwestern China.

    Science.gov (United States)

    Qing, Maofeng; Qiu, Lihua; Gao, Zhi; Bhandari, Kishor

    2014-05-01

    The purpose of the study was to estimate the chronology of third molar mineralization in Han population of southwestern China and find its unique characteristics so that it would provide a reference in several legal cases like forensic age estimation. The study used Demirjian's staging method to study 2192 orthopantomograms of 984 male and 1208 female subjects aged between 8 and 25 years. The statistical data was analyzed by Student's t test and ANOVA. The conclusions of the study are: (1) The chronological mineralization age of third molars of Han population in Southwestern China is similar to the Turkish and the Japanese, was earlier than the Austrian and Han of South China, but later than the Spanish. (2) The mineralization timing of the third molars between two sides in maxilla or mandible has no significant differences in the same gender group. (3) There is no significant difference in mineralization of third molars between male and female, except for tooth 48 in Demirjian's stage E. (4) The mineralization of third molar in maxilla is earlier than mandible.

  3. The Pranemuru project and the radiocarbon chronology of the Sardinian Bronze Age

    Directory of Open Access Journals (Sweden)

    Rubinos, Antonio

    2003-12-01

    Full Text Available New C-14 data collected by a Spanish team working in the Sardinian Pranemuru area, allow usthe possibility of revising the C-14 Chronology for the Nuragic Bronze Age and discussing the reliability of some of the dates, as well as the way they have been published, and their matching with the new official chronology for the Sardinian Bronze and Iron Ages, built on Dendro and C14 sequences for the Italian Peninsula.

    La obtención por parte del Proyecto Pranemuru de cerca de una veintena de dataciones radiocarbónicas para una microregión en época nurágica, de las que aquí se recogen discuten catorce, abre la posibilidad de revisar la cronología de la Edad del Bronce en Cerdeña, a la luz de las dataciones recogidas desde los años 90 por Trump (1990 y Tykot (1994 y, más recientemente, por Webster (2001, discutir la validez de las fechas en función de los criterios de recogida de muestra, contexto arqueológico, desviación estándar y forma en que ha sido publicada, así como contrastarla con la cronología propuesta recientemente para la Protohistoria sarda, de acuerdo con la Dendrocronología y Cronología Radiocarbónica para la Italia peninsular (Lo Schiavo 2002.

  4. Ovarian Aging-Like Phenotype in the Hyperandrogenism-Induced Murine Model of Polycystic Ovary

    OpenAIRE

    Mohammad Amin Rezvanfar; Shojaei Saadi, Habib A; Maziar Gooshe; Amir Hosein Abdolghaffari; Maryam Baeeri; Mohammad Abdollahi

    2014-01-01

    There are prominently similar symptoms, effectors, and commonalities in the majority of characteristics between ovarian aging and polycystic ovarian syndrome (PCOS). Despite the approved role of oxidative stress in the pathogenesis of PCOS and aging, to our knowledge, the link between the PCO(S) and aging has not been investigated yet. In this study we investigated the possible exhibition of ovarian aging phenotype in murine model of PCO induced by daily oral administration of letrozole (1 mg...

  5. Premature ovarian failure (POF): discordance between somatic and reproductive aging.

    Science.gov (United States)

    Pal, Lubna; Santoro, Nanette

    2002-06-01

    Premature ovarian failure (POF) is a unique example of isolated organ senescence, with a population prevalence of approximately 1%. Though the phenotypic expression of POF is similar to that of age-appropriate natural menopause, the underlying pathophysiological mechanisms are diverse and not entirely clear. The impact of POF on the patient is profound, with myriad ramifications, ranging from psychological devastation to multi-system implications of estrogen deprivation and its sequelae. The hastening of degenerative changes noted in these patients however, are not entirely ameliorated with estrogen replacement and POF may indeed represent an acceleration of the aging process.

  6. Modelling Developmental Changes in Repeated-Sprint Ability by Chronological and Skeletal Ages in Young Soccer Players

    NARCIS (Netherlands)

    Valente-dos-Santos, J.; Coelho-e-Silva, M. J.; Martins, R. A.; Figueiredo, A. J.; Cyrino, E. S.; Sherar, L. B.; Vaeyens, R.; Huijgen, B. C. H.; Elferink-Gemser, M. T.; Malina, R. M.

    2012-01-01

    This study investigated the influence of chronological (CA) and skeletal ages (SA), anthropometry, aerobic endurance and lower limb explosive strength on developmental changes in repeated-sprint ability (RSA) in soccer players aged 11-17 years. Participants were annually followed over 5 years, resul

  7. Life-spanning murine gene expression profiles in relation to chronological and pathological aging in multiple organs

    Science.gov (United States)

    Kuiper, Raoul V; van der Hoeven, Tessa V; Wackers, P.F.K.; Robinson, Joke; van der Horst, Gijsbertus TJ; Dollé, Martijn ET; Vijg, Jan; Breit, Timo M; Hoeijmakers, Jan HJ; van Steeg, Harry

    2013-01-01

    Summary Aging and age-related pathology is a result of a still incompletely-understood intricate web of molecular and cellular processes. We present a C57BL/6J female mice in vivo aging study of five organs (liver, kidney, spleen, lung and brain), in which we compare genome-wide gene expression profiles during chronological aging with pathological changes throughout the entire murine lifespan (13, 26, 52, 78, 104 and 130 weeks). Relating gene expression changes to chronological aging revealed many differentially expressed genes (DEGs) and altered gene-sets (AGSs) were found in most organs, indicative of intra-organ generic aging processes. However, only ≤ 1% of these DEGs are found in all organs. For each organ, at least one of 18 tested pathological parameters showed a good age-predictive value, albeit with much inter- and intra-individual (organ) variation. Relating gene expression changes to pathology-related aging revealed correlated genes and gene-sets, which made it possible to characterize the difference between biological and chronological aging. In liver, kidney and brain, a limited number of overlapping pathology-related AGSs were found. Immune responses appeared to be common, yet the changes were specific in most organs. Furthermore, changes were observed in energy homeostasis, reactive oxygen species, cell cycle, cell motility and DNA damage. Comparison of chronological and pathology-related AGSs revealed substantial overlap and interesting differences. For example, the presence of immune processes in liver pathology-related AGSs which were not detected in chronological aging. The many cellular processes that are only found employing aging–related pathology could provide important new insights into the progress of aging. PMID:23795901

  8. Epithelial ovarian carcinoma in women aged below 30 years

    Institute of Scientific and Technical Information of China (English)

    Chen Rong; Shen Keng; Wu Ming; Pan Ling-ya; Huang Hui-fang; Yang Jia-xin; Lang Jing-he

    2005-01-01

    Objective: To study the manifestation, pathohistologic type, stage of disease, treatment and outcome of epithelial ovarian carcinoma in women under the age of 30 years.Methods: The 21 cases of epithelial ovarian carcinoma in women aged below 30 years between Jan, 1986 and Mar, 2002 were analyzed retrospectively.Results: The median age at the time of diagnosis was 24 years (range, 16-29 years). All carcinomas occurred after menarche. The most common symptoms were abdominal pain (50%), followed by tympanites (25%) and menstrual disorders (19%). The initial diagnosis was usually made by physical examination, ultrasonography and serum CA125. The mean maximal tumor diameter was 17.6 cm. Ten patients had Stage I disease (5 Ia, 5 Ic), five had Stage Ⅲ disease, and the other six were unknown during staging operation. There were nine mucinous tumors, six serous tumors. Most tumors were well-differentiated and classified as Grade1 in 11 cases, Grade2 in 2 cases, Grade3 in 2 cases, unknown in 6 cases. Optimal and suboptimal cytoreduction was achieved in 14 patients in primary treatment and 5 in recurrent treatment. 8 patients were treated with conservative surgery. 18 patients were treated with chemotherapy and 7 patients had experienced six or more than six courses of chemotherapy. The median follow-up was 50 months (range, 2-192 months). There were 6 deaths, 2 alive with tumor, 11 alive without the disease, 2 losing follow-up. The 3-year survival rate was 89%, and 5-year survival rate was 76%.Conclusion: Young patients with epithelial ovarian carcinoma appeared to have a less aggressive form of the disease and a more favorable prognosis.

  9. The Later Stone Age calvaria from Iwo Eleru, Nigeria: morphology and chronology.

    Directory of Open Access Journals (Sweden)

    Katerina Harvati

    Full Text Available BACKGROUND: In recent years the Later Stone Age has been redated to a much deeper time depth than previously thought. At the same time, human remains from this time period are scarce in Africa, and even rarer in West Africa. The Iwo Eleru burial is one of the few human skeletal remains associated with Later Stone Age artifacts in that region with a proposed Pleistocene date. We undertook a morphometric reanalysis of this cranium in order to better assess its affinities. We also conducted Uranium-series dating to re-evaluate its chronology. METHODOLOGY/PRINCIPAL FINDINGS: A 3-D geometric morphometric analysis of cranial landmarks and semilandmarks was conducted using a large comparative fossil and modern human sample. The measurements were collected in the form of three dimensional coordinates and processed using Generalized Procrustes Analysis. Principal components, canonical variates, Mahalanobis D(2 and Procrustes distance analyses were performed. The results were further visualized by comparing specimen and mean configurations. Results point to a morphological similarity with late archaic African specimens dating to the Late Pleistocene. A long bone cortical fragment was made available for U-series analysis in order to re-date the specimen. The results (∼11.7-16.3 ka support a terminal Pleistocene chronology for the Iwo Eleru burial as was also suggested by the original radiocarbon dating results and by stratigraphic evidence. CONCLUSIONS/SIGNIFICANCE: Our findings are in accordance with suggestions of deep population substructure in Africa and a complex evolutionary process for the origin of modern humans. They further highlight the dearth of hominin finds from West Africa, and underscore our real lack of knowledge of human evolution in that region.

  10. Glycation associated skin autofluorescence and skin elasticity are related to chronological age and body mass index of healthy subjects

    OpenAIRE

    Corstjens, H.; Dicanio, D.; Muizzuddin, N.; Neven, A.; Sparacio, R.; Declercq, L; D. Maes

    2008-01-01

    Glycation associated skin autofluorescence and skin elasticity are related to chronological age and body mass index of healthy subjects correspondence: Corresponding author. Tel.: +32 14 25 89 04; fax: +32 14 25 88 60. (Corstjens, H.) (Corstjens, H.) Estee Lauder Companies--> , Oevel--> - BELGIUM (Corstjens, H.) BELGIUM (Corstjens, H.) Estee Lauder Companies--> , Melville--> ,...

  11. Correlation between Dental Maturation and Chronological Age in Patients with Cerebral Palsy, Mental Retardation, and Down Syndrome

    Science.gov (United States)

    Diz, P.; Limeres, J.; Salgado, A. F. P.; Tomas, I.; Delgado, L. F.; Vazquez, E.; Feijoo, J. F.

    2011-01-01

    Determining a child's chronological age and stage of maturation is particularly important in fields such as paediatrics, orthopaedics, and orthodontics, as well as in forensic and anthropological studies. Some systemic conditions can cause abnormal physiological maturation, and skeletal maturation is usually more delayed than dental maturation.…

  12. Towards an absolute chronology for the Aegean iron age: new radiocarbon dates from Lefkandi, Kalapodi and Corinth.

    Directory of Open Access Journals (Sweden)

    Michael B Toffolo

    Full Text Available The relative chronology of the Aegean Iron Age is robust. It is based on minute stylistic changes in the Submycenaean, Protogeometric and Geometric styles and their sub-phases. Yet, the absolute chronology of the time-span between the final stages of Late Helladic IIIC in the late second millennium BCE and the archaic colonization of Italy and Sicily toward the end of the 8(th century BCE lacks archaeological contexts that can be directly related to events carrying absolute dates mentioned in Egyptian/Near Eastern historical sources, or to well-dated Egyptian/Near Eastern rulers. The small number of radiocarbon dates available for this time span is not sufficient to establish an absolute chronological sequence. Here we present a new set of short-lived radiocarbon dates from the sites of Lefkandi, Kalapodi and Corinth in Greece. We focus on the crucial transition from the Submycenaean to the Protogeometric periods. This transition is placed in the late 11(th century BCE according to the Conventional Aegean Chronology and in the late 12(th century BCE according to the High Aegean Chronology. Our results place it in the second half of the 11(th century BCE.

  13. Towards an absolute chronology for the Aegean iron age: new radiocarbon dates from Lefkandi, Kalapodi and Corinth.

    Science.gov (United States)

    Toffolo, Michael B; Fantalkin, Alexander; Lemos, Irene S; Felsch, Rainer C S; Niemeier, Wolf-Dietrich; Sanders, Guy D R; Finkelstein, Israel; Boaretto, Elisabetta

    2013-01-01

    The relative chronology of the Aegean Iron Age is robust. It is based on minute stylistic changes in the Submycenaean, Protogeometric and Geometric styles and their sub-phases. Yet, the absolute chronology of the time-span between the final stages of Late Helladic IIIC in the late second millennium BCE and the archaic colonization of Italy and Sicily toward the end of the 8(th) century BCE lacks archaeological contexts that can be directly related to events carrying absolute dates mentioned in Egyptian/Near Eastern historical sources, or to well-dated Egyptian/Near Eastern rulers. The small number of radiocarbon dates available for this time span is not sufficient to establish an absolute chronological sequence. Here we present a new set of short-lived radiocarbon dates from the sites of Lefkandi, Kalapodi and Corinth in Greece. We focus on the crucial transition from the Submycenaean to the Protogeometric periods. This transition is placed in the late 11(th) century BCE according to the Conventional Aegean Chronology and in the late 12(th) century BCE according to the High Aegean Chronology. Our results place it in the second half of the 11(th) century BCE. PMID:24386150

  14. Mandibular third molar development staging to chronologic age and sex in north Indian children and young adults.

    Science.gov (United States)

    Rai, B; Kaur, J; Anand, S C

    2009-12-01

    Age estimation is not only important for clinical but also for medico-legal purposes. The present study is an attempt to estimate the chronologic age based on the stages of third molar development following the eight stages (A-H) method of Demirjian et al8 and to compare third molar development by sex and age. We examined 250 orthopantomograms of young north Indian subjects of known chronologic age (range, 7-26 years). Statistical analysis was performed using the Mann-Whitney U-test and the Wilcoxon test between sex and age. Regression analysis was performed to obtain BR regression formulae for dental age calculation with the chronologic age. Statistically significant differences in mandibular third-molar development between males and females were revealed regarding the calcification stages D and G. The results further indicated that third-molar formation was attained earlier in females than in males. Statistical analysis showed a strong correlation between age and third-molar development for both the sexes.

  15. Chronological versus dental age in subjects from 5 to 19 years: a comparative study with forensic implications

    Directory of Open Access Journals (Sweden)

    Claudia Corral

    2010-10-01

    Full Text Available Objectives: This study evaluated six methods used in estimating the age of patients attending the Dental School at Universidad del Valle, evaluating dental development by using panoramic radiographs. Additionally, the study determined the sexual identity of the person and the bilateral symmetry of development, the maturity and the chronological eruption of permanent teeth. Materials and methods: This is a descriptive, quantitative and transversal study that evaluated which of the six methods (Logan & Kronfeld; Schour & Massler; Moorrees, Fanning & Hunt; Demirjian, Goldstein & Tanner; Ubelaker & Smith for estimating the age of a patient through radiographic evaluation of dental development is the most correlated with the chronological age of the patient, so it can be used for forensic purposes. Results: The Moorrees, Fanning & Hunt and the Smith methods showed high correlation (0.7874 and 0.7808, respectively. The Logan & Kronfeld methods presented low correlation (0.6879. The sample studied did not show sexual dimorphism or bilateral asymmetry. Conclusions: All methods evaluated have a high correlation coefficient between the dental age and the radiographic age. However, the Moorrees, Fanning & Hunt, and Smith methods presented higher correlation coefficients between dental and chronological age.

  16. Chronological versus dental age in subjects from 5 to 19 years: a comparative study with forensic implications

    Directory of Open Access Journals (Sweden)

    Freddy Moreno

    2010-09-01

    Full Text Available Objectives: This study evaluated six methods used in estimating the age of patients attending the Dental School at Universidad del Valle, evaluating dental development by using panoramic radiographs. Additionally, the study determined the sexual identity of the person and the bilateral symmetry of development, the maturity and the chronological eruption of permanent teeth.Materials and methods: This is a descriptive, quantitative and transversal study that evaluated which of the six methods (Logan & Kronfeld; Schour & Massler; Moorrees, Fanning & Hunt; Demirjian, Goldstein & Tanner; Ubelaker & Smith for estimating the age of a patient through radiographic evaluation of dental development is the most correlated with the chronological age of the patient, so it can be used for forensic purposes.Results: The Moorrees, Fanning & Hunt and the Smith methods showed high correlation (0.7874 and 0.7808, respectively. The Logan & Kronfeld methods presented low correlation (0.6879. The sample studied did not show sexual dimorphism or bilateral asymmetry.Conclusions: All methods evaluated have a high correlation coefficient between the dental age and the radiographic age. However, the Moorrees, Fanning & Hunt, and Smith methods presented higher correlation coefficients between dental and chronological age.

  17. Pathophysiological factors in the relationship between chronological age and calculated lung age as detected in a screening setting in community-dwelling subjects

    Directory of Open Access Journals (Sweden)

    Peter eKardos

    2016-02-01

    Full Text Available Aim: To explore the relationship between pathophysiological factors and premature lung ageing in a cohort of community-dwelling subjects in a health-screening setting. Methods: 16,107 pharmacy customers in Germany (5954 males, 10153 females; mean age 59.7 years participated in a lung function screening project by providing demographic data including smoking status and known airway conditions and performing spirometry with a Vitalograph, a spirometry screening device. Lung age was calculated from the spirometric findings, and the difference between chronological age and calculated lung age was analyzed in its relationship to the demographic data in general linear models. Results: In the overall cohort, calculated lung age exceeded chronological age by 10.0 years. Based on the subset of non-smokers not reporting any airway conditions, Vitalograph data in this setting may underestimate FEV1 to some degree but this apparently had little impact on the detection of association of lung age with pathophysiological factors or the corresponding effect sizes. The most important factors associated with greater lung age based on strength of association were presence of dyspnea, being a smoker and reporting a history of COPD or asthma. Corresponding effect sizes for the difference between age and lung age were 6.5, 5.7, 13.9 and 8.3 years over the chronological age. Discussion and Conclusions: These data confirm the usefulness of screening devices of lung function testing for epidemiological but potentially also for pharmaco-epidemiological studies.

  18. Semantic Verbal Fluency in Children with and without Autism Spectrum Disorder: Relationship with Chronological Age and IQ.

    Science.gov (United States)

    Pastor-Cerezuela, Gemma; Fernández-Andrés, Maria-Inmaculada; Feo-Álvarez, Mireia; González-Sala, Francisco

    2016-01-01

    We administered a semantic verbal fluency (SVF) task to two groups of children (age range from 5 to 8): 47 diagnosed with Autism Spectrum Disorder (ASD Group) and 53 with typical development (Comparison Group), matched on gender, chronological age, and non-verbal IQ. Four specific indexes were calculated from the SVF task, reflecting the different underlying cognitive strategies used: clustering (component of generativity and lexical-semantic access), and switching (executive component, cognitive flexibility). First, we compared the performance of the two groups on the different SVF task indicators, with the ASD group scoring lower than the Comparison Group, although the difference was greater on switching than on clustering. Second, we analyzed the relationships between the different SVF measures and chronological age, verbal IQ and non-verbal IQ. While in the Comparison Group chronological age was the main predictor of performance on the SVF task, in the ASD Group verbal IQ was the best predictor. In the children with ASD, therefore, greater linguistic competence would be associated with better performance on the SVF task, which should be taken into account in speech therapies designed to achieve improvements in linguistic generativity and cognitive flexibility. PMID:27379002

  19. Ovarian Germline Stem Cells (OGSCs and the Hippo Signaling Pathway Association with Physiological and Pathological Ovarian Aging in Mice

    Directory of Open Access Journals (Sweden)

    Jia Li

    2015-07-01

    Full Text Available Background: The Hippo signaling pathway plays fundamental roles in stem cell maintenance in a variety of tissues and has thus implications for stem cell biology. Key components of this recently discovered pathway have been shown to be associated with primordial follicle activation. However, whether the Hippo signaling pathway plays a role in the development of Ovarian Germline Stem Cells (OGSCs during physiological and pathological ovarian aging in mice is unknown. Methods: Mice at the age of 7 days (7D, or of 2, 10, or 20 months (2M, 10M, 20M and mice at 2M treated with TPT and CY/BUS drugs were selected as physiological and pathological ovarian aging models, respectively. Immunohistochemistry was used to assess the development of follicles, and the co-localization of genes characteristic of OGSCs with MST1, LATS2 and YAP1 was assessed by immunofluorescence, western blotting and real-time PCR methods. Results: The Hippo signal pathway and MVH/OCT4 genes were co-expressed in the mouse ovarian cortex. The level and co-localization of LATS2, MST1, MVH, and OCT4 were significantly decreased with increased age, but YAP1 was more prevalent in the mouse ovarian cortex of 2M mice than 7D mice and was not observed in 20M mice. Furthermore, YAP1, MVH, and OCT4 were gradually decreased after TPT and CY/BUS treatment, and LATS2 mRNA and protein up-regulation persisted in TPT- and CY/BUS-treated mice. However, the expression of MST1 was lower in the TPT and CY/BUS groups compared with the control group. In addition, pYAP1 protein showed the highest expression in the ovarian cortexes of 7D mice compared with 20M mice, and the value of pYAP1/YAP1 decreased from 7D to 20M. Moreover, pYAP1 decreased in the TPT- and CY/BUS-treated groups, but the value of pYAP1/YAP1 increased in these groups. Conclusion: Taken together, our results show that the Hippo signaling pathway is associated with the changes that take place in OGSCs during physiological and pathological

  20. Possibilities and limits of ovarian reserve testing in ART.

    Science.gov (United States)

    La Marca, Antonio; Argento, Cindy; Sighinolfi, Giovanna; Grisendi, Valentina; Carbone, Marilena; D'Ippolito, Giovanni; Artenisio, Alfredo Carducci; Stabile, Gaspare; Volpe, Annibale

    2012-03-01

    Markers of ovarian reserve are associated with ovarian aging as they decline with chronologic age, and hence may predict stages of reproductive aging including the menopause transition. Assessment of ovarian reserve include measurement of serum follicle stimulating hormone (FSH), anti-M�llerian hormone (AMH), and inhibin-B. Ultrasound determination of antral follicle count (AFC), ovarian vascularity and ovarian volume also can have a role. The clomiphene citrate challenge test (CCCT), exogenous FSH ovarian reserve test (EFORT), and GnRH-agonist stimulation test (GAST) are dynamic methods that have been used in the past to assess ovarian reserve. In infertile women, ovarian reserve markers can be used to predict low and high oocyte yield and treatment failure in women undergoing in vitro fertilization. However the markers may have limitations when an in depth analysis of their accuracy, cost, convenience, and utility is performed. As ovarian reserve markers may permit the identification of both the extremes of ovarian stimulation, a possible role for their measurement may be in the individualization of treatment strategies in order to reduce the clinical risk of ART along with optimized treatment burden. It is fundamental to clarify the cost/benefit of its use in the ovarian reserve testing before initiation of an IVF cycle and whether the ovarian reserve markers-determined strategy of ovarian stimulation for assisted conception may be associated to improved live birth rate.

  1. PATTERN OF OVARIAN TUMORS AND THEIR AGE DISTRIBUTION IN KANGRA VALLEY , HIMACHAL PRADESH

    Directory of Open Access Journals (Sweden)

    Mani

    2015-07-01

    Full Text Available A female’s risk at birth of having ovarian tumors in her lifetime is 6 - 7%. Relative frequency of ovarian tumor is different for western and Asian countries. Two third of ovarian tumors occur in women of reproductive age group. This study is done in Dr. RPGMC and Hospital with the aim to find out frequency o f different histological types of ovarian tumors and their age distribution in Kangra valley. One hundred forty eight ovarian tumors , reported were included in this study. One hundred sixteen cases (78.4% are benign , twenty eight (18.9% are malignant & f our (2.7% are borderline ovarian tumors. Histologically surface epithelial tumors were the commonest (77.7% followed by germ cell Tumors (15.5% , sex cord stromal tumors (6.1% and metastatic tumors (2.0%. Serous cyst adenoma is commonest benign tumor ( 50.9% and serous cystadenocarcinoma are the commonest malignant tumors (42.9% of all age groups. Benign tumors were more common than malignant ones. Most ovarian tumors (69.6% were seen between the age of 20 - 49 years whereas most malignant tumors (71.4% were seen above the age of 40 years. In 3 rd , 4 th , 5 th decades , Surface epithelial Tumors were more common (74.8% than other tumors. There is no study in this field in Himachal area , which reflects various ovarian tumour’s frequency and also their relationship with the age of the patient. Our study gave a broad view about ovarian neoplasm which is helpful for clinician to do early diagnosis and early treatment.

  2. The significance of peroxisome function in chronological aging of Saccharomyces cerevisiae

    NARCIS (Netherlands)

    Lefevre, Sophie D.; van Roermund, Carlo W.; Wanders, Ronald J. A.; Veenhuis, Marten; van der Klei, Ida J.

    2013-01-01

    Summary We studied the chronological lifespan of glucose-grown Saccharomyces cerevisiae in relation to the function of intact peroxisomes. We analyzed four different peroxisome-deficient (pex) phenotypes. These included Delta pex3 cells that lack peroxisomal membranes and in which all peroxisomal pr

  3. Ovarian Aging-Like Phenotype in the Hyperandrogenism-Induced Murine Model of Polycystic Ovary

    Directory of Open Access Journals (Sweden)

    Mohammad Amin Rezvanfar

    2014-01-01

    Full Text Available There are prominently similar symptoms, effectors, and commonalities in the majority of characteristics between ovarian aging and polycystic ovarian syndrome (PCOS. Despite the approved role of oxidative stress in the pathogenesis of PCOS and aging, to our knowledge, the link between the PCO(S and aging has not been investigated yet. In this study we investigated the possible exhibition of ovarian aging phenotype in murine model of PCO induced by daily oral administration of letrozole (1 mg/kg body weight for 21 consecutive days in the female Wistar rats. Hyperandrogenization showed irregular cycles and histopathological characteristics of PCO which was associated with a significant increase in lipid peroxidation (LPO and reactive oxygen species (ROS and decrease in total antioxidant capacity (TAC in serum and ovary. Moreover, serum testosterone, insulin and tumor necrosis factor-alpha (TNF-α levels, and ovarian matrix metalloproteinase-2 (MMP-2 were increased in PCO rats compared with healthy controls, while estradiol and progesterone diminished. Almost all of these findings are interestingly found to be common with the characteristics identified with (ovarian aging showing that hyperandrogenism-induced PCO in rat is associated with ovarian aging-like phenotypes. To our knowledge, this is the first report that provides evidence regarding the phenomenon of aging in PCO.

  4. Age-related decline in ovarian follicle stocks differ between chimpanzees (Pan troglodytes) and humans

    OpenAIRE

    Cloutier, Christina T.; COXWORTH, JAMES E.; Hawkes, Kristen

    2015-01-01

    Similarity in oldest parturitions in humans and great apes suggests that we maintain ancestral rates of ovarian aging. Consistent with that hypothesis, previous counts of primordial follicles in postmortem ovarian sections from chimpanzees (Pan troglodytes) showed follicle stock decline at the same rate that human stocks decline across the same ages. Here, we correct that finding with a chimpanzee sample more than three times larger than the previous one, which also allows comparison into old...

  5. Attitudes towards ads and age. A study in seniors. The combination of chronological and cognitive age as an effective predictive criterion of attitudes

    OpenAIRE

    Moliner Tena, Miguel Ángel; Estrada Guillén, Marta; Monferrer Tirado, Diego; Sánchez García, Javier

    2014-01-01

    Older adults make up one of the markets with the greatest potential in the future. It is essential that businesses take the diversity within this group into account, and perform segmentation in order to obtain a favorable attitude towards the ad. The potential for segmentation by chronological age has been called into question in recent years, with cognitive age emerging as the main alternative. This research aims to analyses the relationship between the variables of attitude towards the ad, ...

  6. The reliability of chronological age determination by means of mandibular third molar development in subjects in Croatia.

    Science.gov (United States)

    Legović, Mario; Sasso, Anja; Legović, Izak; Brumini, Gordana; Cabov, Tomislav; Slaj, Martina; Vancura, Irena; Lapter, Marina

    2010-01-01

    The aim of this study was to determine the development of the mandibular third molar and its relation to chronological age. The evaluated material consisted of 979 orthopantomograms of patients of Croatian Caucasian origin aged between 5.7 and 14.6 years. Third molar developmental stages were evaluated according to the stages proposed by Nolla. The frequencies of different stages of mineralization and the mean value of the mineralization of the mandibular third molars with regard to age, gender, and size of the mandible were determined and the coefficient of correlation determined between the age of the subject and the stage of development of the mandibular molars. Statistically significant correlation was determined between mineralization of the mandibular third molar and chronological age of the subjects (boys, mandibular left third molar r = 0.779, right third molar r = 0.793; girls, mandibular left third molar r = 0.746, right third molar r = 0.725). It can be concluded that the accuracy of age estimation based on Nolla's method is applicable for Croatian children.

  7. Assessment of skeletal age using MP 3 and hand-wrist radiographs and its correlation with dental and chronological ages in children

    Directory of Open Access Journals (Sweden)

    Bala M

    2010-06-01

    Full Text Available The purpose of the study was to assess skeletal age using MP 3 and hand-wrist radiographs and to find the correlation amongst the skeletal, dental and chronological ages. One hundred and sixty North-Indian healthy children in the age group 8-14 years, comprising equal number of males and females were included in the study. The children were radiographed for middle phalanx of third finger (MP 3 and hand-wrist of the right hand and intra oral periapical X-ray for right permanent maxillary canine. Skeletal age was assessed from MP 3 and hand-wrist radiographs according to the standards of Greulich and Pyle. The dental age was assessed from IOPA radiographs of right permanent maxillary canine based on Nolla′s calcification stages. Skeletal age from MP 3 and hand-wrist radiographs shows high correlation in all the age groups for both sexes. Females were advanced in skeletal maturation than males. Skeletal age showed high correlation with dental age in 12-14 years age group. Chronological age showed inconsistent correlation with dental and skeletal ages.

  8. Bone morphogenetic protein-15 in follicle fluid combined with age may differentiate between successful and unsuccessful poor ovarian responders

    Directory of Open Access Journals (Sweden)

    Wu Yan-Ting

    2012-12-01

    Full Text Available Abstract Background The counselling of poor ovarian responders about the probability of pregnancy remains a puzzle for gynaecologists. The aim of this study was to optimise the management of poor responders by investigating the role of the oocyte-derived factor bone morphogenetic protein-15 (BMP-15 combined with chronological age in the prediction of the outcome of in-vitro fertilisation-embryo transfer (IVF-ET in poor responders. Methods A retrospective study conducted in a university hospital. A total of 207 poor ovarian responders who reached the ovum pick-up stage undergoing IVF/intracytoplasmic sperm injection (ICSI with three or fewer follicles no less than 14 mm on the day of oocyte retrieval were recruited from July 1, 2008 to December 31, 2009. Another 215 coinstantaneous cycles with normal responses were selected as controls. The BMP-15 levels in the follicular fluid (FF of the 207 poor responders were analysed by western blot. Based on the FF BMP-15 level and age, poor responders were sub-divided into four groups. The main outcome measures were the FF BMP-15 level, implantation rate, pregnancy rate, and live birth rate. Results The implantation rate (24.2% vs. 15.3%, chemical pregnancy rate (40% vs. 23.7%, clinical pregnancy rate (36.5% vs. 20.4% and live birth rate (29.4% vs. 15.1% in the high BMP-15 group were significantly higher than those in the low BMP-15 group. Furthermore, poor responders aged less than or equal to 35 years with a higher FF BMP-15 level had the best implantation, pregnancy and live birth rates, which were comparable with those of normal responders. Conclusions Our study suggests a potential role of BMP-15 in the prediction of the IVF outcome. A high FF BMP-15 combined with an age less than or equal to 35 years may be used as a potential indicator for repeating IVF cycles in poor ovarian responders.

  9. Differences in ovarian aging patterns between races are associated with ovarian genotypes and sub-genotypes of the FMR1 gene

    Directory of Open Access Journals (Sweden)

    Gleicher Norbert

    2012-09-01

    Full Text Available Abstract Background Ovarian aging patterns differ between races, and appear to affect fertility treatment outcomes. What causes these differences is, however, unknown. Variations in ovarian aging patterns have recently been associated with specific ovarian genotypes and sub-genotypes of the FMR1 gene. We, therefore, attempted to determine differences in how functional ovarian reserve (FOR changes with advancing age between races, and whether changes are associated with differences in distribution of ovarian genotypes and sub-genotypes of the FMR1 gene. Methods We determined in association with in vitro fertilization (IVF FOR in 62 young Caucasian, African and Asian oocyte donors and 536 older infertility patients of all three races, based on follicle stimulating hormone (FSH, anti-Müllerian hormone (AMH and oocyte yields, and investigated whether differences between races are associated with differences in distribution of FMR1 genotypes and sub-genotypes. Results Changes in distribution of mean FSH, AMH and oocyte yields between young donors and older infertility patients were significant (all P FMR1 genotypes and sub-genotypes in patients varied significantly between races, with Asians demonstrating fewer het-norm/low sub-genotypes than Caucasians and Africans (P = 0.012. Conclusion FOR changes in different races at different rates, and appears to parallel ovarian FMR1 genotypes and sub-genotype distributions. Differences in ovarian aging between races may, therefore, be FMR1-associated.

  10. The WAIS-Divide deep ice core WD2014 chronology – Part 2: Methane synchronization (68–31 ka BP and the gas age-ice age difference

    Directory of Open Access Journals (Sweden)

    C. Buizert

    2014-08-01

    Full Text Available The West Antarctic Ice Sheet (WAIS-Divide ice core (WAIS-D is a newly drilled, high-accumulation deep ice core that provides Antarctic climate records of the past ∼68 ka at unprecedented temporal resolution. The upper 2850 m (back to 31.2 ka BP have been dated using annual-layer counting. Here we present a chronology for the deep part of the core (67.8–31.2 ka BP, which is based on stratigraphic matching to annual-layer-counted Greenland ice cores using globally well-mixed atmospheric methane. We calculate the WAIS-D gas age-ice age difference (Δage using a combination of firn densification modeling, ice flow modeling, and a dataset of δ15N-N2, a proxy for past firn column thickness. The largest Δage at WAIS-D occurs during the last glacial maximum, and is 525 ± 100 years. Internally consistent solutions can only be found when assuming little-to-no influence of impurity content on densification rates, contrary to a recently proposed hypothesis. We synchronize the WAIS-D chronology to a linearly scaled version of the layer-counted Greenland Ice Core Chronology (GICC05, which brings the age of Dansgaard-Oeschger (DO events into agreement with the U/Th absolutely dated Hulu speleothem record. The small Δage at WAIS-D provides valuable opportunities to investigate the timing of atmospheric greenhouse gas variations relative to Antarctic climate, as well as the interhemispheric phasing of the bipolar "seesaw".

  11. Ice Core Depth-Age Relation for Vostok delta-D and Dome Fuji delta-18O Records Based on the Devils Hole Paleotemperature Chronology

    Science.gov (United States)

    Landwehr, Jurate Maciunas

    2002-01-01

    This report presents the data for the Vostok - Devils Hole chronology, termed V-DH chronology, for the Antarctic Vostok ice core record. This depth - age relation is based on a join between the Vostok deuterium profile (D) and the stable oxygen isotope ratio (18O) record of paleotemperature from a calcitic core at Devils Hole, Nevada, using the algorithm developed by Landwehr and Winograd (2001). Both the control points defining the V-DH chronology and the numeric values for the chronology are given. In addition, a plausible chronology for a deformed bottom portion of the Vostok core developed with this algorithm is presented. Landwehr and Winograd (2001) demonstrated the broader utility of their algorithm by applying it to another appropriate Antarctic paleotemperature record, the Antarctic Dome Fuji ice core 18O record. Control points for this chronology are also presented in this report but deemed preliminary because, to date, investigators have published only the visual trace and not the numeric values for the Dome Fuji 18O record. The total uncertainty that can be associated with the assigned ages is also given.

  12. Ovarian reserve in women of late reproductive age by the method of treatment of PCOS

    Directory of Open Access Journals (Sweden)

    Ketevan Beltadze

    2015-05-01

    Full Text Available Background: The prevalence of polycystic ovarian syndrome (PCOS particularly is increased in adolescents. Very few longitudinal follow-up for assessment of ovarian reserve in women of late reproductive age with previously confirmed PCOS have been conducted, especially after its diagnosis and treatment in adolescence. Objective: The aim of the present study was to compare of the ovarian reserve of the women of late reproductive age by the method of treatment of PCOS in adolescence. Materials and Methods: This cross sectional study in an unselected population was conducted from January to June 2014. A total of 123 women of late reproductive age were included. They had been diagnosed with PCOS between 1984 and 1990 when they were 13-18 yr. From these, first group of the study was consisted of 67 participants who underwent conservative treatment with antiandrogens and combined oral contraceptives and second group of the study was consisted of 56 participants after surgery (34-bilateral ovarian drilling and 22- ovarian wedge resection. At the time of investigation patients were 35-45 yr. The participants were collected via analysis of histories at primary diagnosis of PCOS in adolescence and at the time of the investigation analyses of reproductive hormones were conducted. Data were compared between the groups. Results: After conservative treatment PCOS women had higher levels of anti- mullerian hormone and lower follicle-stimulating hormone levels (p=0.02 and p=0.04, respectively. The number of antral follicles and mean ovarian volume were significantly greater also, than in women who underwent surgical treatment (p=0.03 and p=0.04, respectively. Conclusion: Our data suggest that PCOS patients who underwent conservative treatment have the better ovarian reserve than women who underwent surgical treatment of PCOS in adolescence.

  13. Pre-aged plant waxes in tropical lake sediments and their influence on the chronology of molecular paleoclimate proxy records

    Science.gov (United States)

    Douglas, Peter M. J.; Pagani, Mark; Eglinton, Timothy I.; Brenner, Mark; Hodell, David A.; Curtis, Jason H.; Ma, Keith F.; Breckenridge, Andy

    2014-09-01

    Sedimentary records of plant-wax hydrogen (δDwax) and carbon (δ13Cwax) stable isotopes are increasingly applied to infer past climate change. Compound-specific radiocarbon analyses, however, indicate that long time lags can occur between the synthesis of plant waxes and their subsequent deposition in marginal marine sediments. The influence of these time lags on interpretations of plant-wax stable isotope records is presently unconstrained, and it is unclear whether such time lags also affect lacustrine sediments. We present compound-specific radiocarbon (14Cwax) data for n-alkanoic acid plant waxes (n-C26 to n-C32) from: (1) a sediment core from Lake Chichancanab, Yucatan Peninsula, Mexico, (2) soils in the Lake Chichancanab catchment, and (3) surface sediments from three other lakes in southeastern Mexico and northern Guatemala. 14Cwax ages in the surface sediments are consistently older than modern, and may be negatively correlated with mean annual precipitation and positively correlated with lake catchment area. 14Cwax ages in soils surrounding Lake Chichancanab increase with soil depth, consistent with deep, subsoil horizons being the primary source of lacustrine aged plant waxes, which are likely delivered to lake sediments through subsurface transport. Plant waxes in the Lake Chichancanab core are 350-1200 years older than corresponding ages of bulk sediment deposition, determined by 14C dates on terrestrial plant macrofossils in the core. A δDwax time series is in closer agreement with other regional proxy hydroclimate records when a plant-wax 14C age model is applied, as opposed to the macrofossil-based core chronology. Inverse modeling of plant-wax age distribution parameters suggests that plant waxes in the Lake Chichancanab sediment core derive predominantly from millennial-age soil carbon pools that exhibit relatively little age variance (<200 years). Our findings demonstrate that high-temporal-resolution climate records inferred from stable isotope

  14. Re-evaluation of the age model for North Atlantic Ocean Site 982 – arguments for a return to the original chronology

    Directory of Open Access Journals (Sweden)

    K. T. Lawrence

    2013-04-01

    Full Text Available Recently, the veracity of the published chronology for the Pliocene section of North Atlantic Ocean Drilling Program Site 982 was called into question. Here, we examine the robustness of the original age model as well as the proposed age model revision. The proposed revision is predicated on an apparent mis-identification of the depth to the Gauss-Matuyama (G/M polarity chronozone reversal boundary (2.581 Ma based on preliminary shipboard paleomagnetic data and offers a new chronology which includes a hiatus between ~ 3.2 and 3 Ma. However, an even more accurate shore-based, u-channel-derived polarity chronozone stratigraphy for the past ~ 2.7 Ma supports the shipboard composite stratigraphy and demonstrates that the original estimate of the depth of the G/M reversal in the Site 982 record is correct. Thus, the main justification forwarded to support the revised chronology is not valid. We demonstrate that the proposed revision results in a pronounced anomaly in sedimentation rates proximal to the proposed hiatus, erroneous assignment of marine-isotope stages in the Site 982 Pliocene benthic stable oxygen isotope stratigraphy, and a markedly worse correlation of proxy records between this site and other regional paleoclimate data. We conclude that the original chronology for Site 982 is a far more accurate age-model than that which arises from the published revision. We strongly recommend the use of the original chronology for all future work at Site 982.

  15. Re-evaluation of the age model for North Atlantic Ocean Site 982 – arguments for a return to the original chronology

    Directory of Open Access Journals (Sweden)

    K. T. Lawrence

    2013-10-01

    Full Text Available Recently, the veracity of the published chronology for the Pliocene section of North Atlantic Ocean Drilling Program Site 982 was called into question. Here, we examine the robustness of the original age model as well as the proposed age model revision. The proposed revision is predicated on an apparent misidentification of the depth to the Gauss–Matuyama (G/M polarity chronozone reversal boundary (2.581 Ma based on preliminary shipboard paleomagnetic data, and offers a new chronology that includes a hiatus between ~3.2 and 3 Ma. However, an even more accurate shore-based, u-channel-derived polarity chronozone stratigraphy for the past ~2.7 Ma supports the shipboard composite stratigraphy and demonstrates that the original estimate of the depth of the G/M reversal in the Site 982 record is correct. Thus, the main justification forwarded to support the revised chronology no longer exists. We demonstrate that the proposed revision results in a pronounced anomaly in sedimentation rates proximal to the proposed hiatus, erroneous assignment of marine-isotope stages in the Site 982 Pliocene benthic stable oxygen isotope stratigraphy, and a markedly worse correlation of proxy records between this site and other regional paleoclimate data. We conclude that the original chronology for Site 982 is a far more accurate age model than that which arises from the published revision. We strongly recommend the use of the original chronology for all future work at Site 982.

  16. Chronological Age, Cognitions, and Practices in European American Mothers: A Multivariate Study of Parenting

    Science.gov (United States)

    Bornstein, Marc H.; Putnick, Diane L.

    2007-01-01

    The authors studied multiple parenting cognitions and practices in European American mothers (N=262) who ranged from 15 to 47 years of age. All were 1st-time parents of 20-month-old children. Some age effects were 0; others were linear or nonlinear. Nonlinear age effects determined by spline regression showed significant associations to a "knot"…

  17. Ovarian cancer at young age: the contribution of mismatch-repair defects in a population-based series of epithelial ovarian

    DEFF Research Database (Denmark)

    Domanska, K; Malander, S; Måsbäck, A;

    2007-01-01

    At least one of ten patients with ovarian cancer is estimated to develop their tumor because of heredity with the breast and ovarian cancer syndrome due to mutations in the BRCA1 and BRCA2 genes and hereditary nonpolyposis colorectal cancer (HNPCC) being the major genetic causes. Cancer at young...... and endometrioid cancers were overrepresented and were diagnosed in 27% and 16% of the tumors, respectively. Immunostaining using antibodies against MLH1, PMS2, MSH2, and MSH6 was used to assess the mismatch-repair status and revealed loss of expression of MLH1/PMS2 in two cases, loss of MSH2/MSH6 in one case...... age is a hallmark of heredity, and ovarian cancers associated with HNPCC have been demonstrated to develop at a particularly early age. We used the Swedish Cancer Registry to identify a population-based series of 98 invasive epithelial ovarian cancers that developed before 40 years. Mucinous...

  18. Chronology of Pliocene and Quaternary bioevents and climatic events from fission-track ages on tephra beds, Wairarapa, New Zealand

    Science.gov (United States)

    Shane, Phil; Froggatt, Paul; Black, Tasha; Westgate, John

    1995-02-01

    High-resolution Pliocene and Pleistocene sequences exposed on land in New Zealand are some of the few detailed records of widepread marine bioevents and paleoclimatic changes in the Southern Hemisphere. Marine biostratigraphy calibrated in deep-sea cores by paleomagnetic reversals has been the primary basis for the chronology of these sequences. We have determined ages for several tephra beds which now provide an independent numerical age calibration for a well-studied marine and terrestrial section in Wairarapa. By using the isothermal plateau fission track (ITPFT) method on volcanic glass we have overcome the problems of partial track fading and detrital mineral contamination, which hindered earlier studies, to reveal a new chronology extending back to nearly 5 Ma. Our ages for the Hikawera Tuff (4.91 ± 0.25 Ma) and Spooner Tuff (3.44 ± 0.13 Ma) are consistent with the appearance and disappearance of many early Pliocene foraminiferial species, validating their age calibration in New Zealand. However, some fossil occurrences, including coccoliths, differ temporally by as much as 0.55 Ma, perhaps due to local tectonic-induced recycling. Four Pleistocene tephra beds (Potaka tephra (1.00 ± 0.03 Ma), Kaukatea tephra (0.87 ± 0.05 Ma), Rangitawa tephra (ca. 0.35 Ma) and Kawakawa tephra (ca. 0.22 Ma)) are now recognised in the Wairarapa sequence via stratigraphic and new geochemical and age data. These beds allow direct correlation to other marine and terrestrial basins, as well as volcanic regions in New Zealand, and will ultimately aid in a regional paleoenvironmental reconstruction where bioevents are absent. The tephra ages indicate that the marine sediment accumulation rates varied from 90 to 250 m/Ma between different sections of the Pliocene and reached ca. 350 m/Ma in the last 2.4 Ma, when the sequence displays pronounced glacioeustatic cyclic deposition. In the terrestrial realm, the oldest loess in New Zealand is now constrained to between 1.00 and 0.87 Ma.

  19. Lichenometry in the Cordillera Blanca, Peru : "Little Ice Age" moraine chronology

    OpenAIRE

    O. Solomina; Jomelli, Vincent; Kaser, G.; Ames, A; Berger, B; Pouyaud, Bernard (dir.)

    2007-01-01

    This paper is a comparison and compilation of lichenometric and geomorphic studies performed by two independent teams in the Cordillera Blanca, Peru, in 1996 and 2002 on 66 "Little Ice Age" moraines of 14 glaciers. Using eleven new control points, we recalibrated the initial rapid growth phase of the previously established Rhizocarpon subgenus Rhizocarpon growth curve. This curve was then used to estimate the age of "Little Ice Age" moraines. The time of deposition of the most prominent and n...

  20. Assessment of Telomere Length in Archived Formalin-Fixed, Paraffinized Human Tissue Is Confounded by Chronological Age and Storage Duration.

    Science.gov (United States)

    Kong, Po-Lian; Looi, Lai-Meng; Lau, Tze-Pheng; Cheah, Phaik-Leng

    2016-01-01

    Telomeres shorten with physiological aging but undergo substantial restoration during cancer immortalization. Increasingly, cancer studies utilize the archive of formalin-fixed, paraffin-embedded (FFPE) tissues in diagnostic pathology departments. Conceptually, such studies would be confounded by physiological telomere attrition and loss of DNA integrity from prolonged tissue storage. Our study aimed to investigate these two confounding factors. 145 FFPE tissues of surgically-resected, non-diseased appendixes were retrieved from our pathology archive, from years 2008 to 2014. Cases from 2013 to 2014 were categorized by patient chronological age (0-20 years, 21-40 years, 41-60 years, > 60 years). Telomere lengths of age categories were depicted by telomere/chromosome 2 centromere intensity ratio (TCR) revealed by quantitative fluorescence in situ hybridization. Material from individuals aged 0-20 years from years 2013/2014, 2011/2012, 2009/2010, and 2008 were compared for storage effect. Telomere integrity was assessed by telomere fluorescence intensity (TFI). Epithelial TCRs (mean ± SD) for the respective age groups were 4.84 ± 2.08, 3.64 ± 1.21, 2.03 ± 0.37, and 1.93 ± 0.45, whereas corresponding stromal TCRs were 5.16 ± 2.55, 3.84 ± 1.36, 2.49 ± 1.20, and 2.93 ± 1.24. A trend of inverse correlation with age in both epithelial and stromal tissues is supported by r = -0.69, p tissues, and suggest that an age-based reference can be established for telomere studies on FFPE tissues. We also showed that FFPE tissues archived beyond 2 years are suboptimal for telomere analysis. PMID:27598341

  1. Ovarian reserve

    NARCIS (Netherlands)

    Macklon, NS; Fauser, BCJM

    2005-01-01

    The tendency to delay childbirth has increased the importance of ovarian reserve as a determinant of infertility treatment outcome. In the context of assisted reproduction technology, effective strategies to overcome the impact of ovarian aging and diminished ovarian reserve on pregnancy chances rem

  2. Ovarian morphology and function during growth hormone therapy of short girls born small for gestational age

    DEFF Research Database (Denmark)

    Tinggaard, Jeanette; Jensen, Rikke Beck; Sundberg, Karin;

    2014-01-01

    normal reference ranges. Ovarian follicles became visible in 58% after 1 year compared with 28% before GH therapy. Anti-Müllerian hormone increased significantly during the 3 years of GH therapy but remained within the normal range. Precocious puberty was observed in one girl; another girl developed......OBJECTIVE: To study the effect of growth hormone (GH) treatment on ovarian and uterine morphology and function in short, prepubertal small-for-gestational-age (SGA) girls.DESIGN: A multinational, randomized controlled trial on safety and efficacy of GH therapy in short, prepubertal children born......(S): Data on anthropometrics, reproductive hormones, and ultrasonographic examination of the internal genitalia were collected during 36 months of GH treatment.RESULT(S): Uterine and ovarian volume increased significantly during 3 years of treatment (64% and 110%, respectively) but remained low within...

  3. Manipulation of Ovarian Function Significantly Influenced Sarcopenia in Postreproductive-Age Mice

    Science.gov (United States)

    Peterson, Rhett L.

    2016-01-01

    Previously, transplantation of ovaries from young cycling mice into old postreproductive-age mice increased life span. We anticipated that the same factors that increased life span could also influence health span. Female CBA/J mice received new (60 d) ovaries at 12 and 17 months of age and were evaluated at 16 and 25 months of age, respectively. There were no significant differences in body weight among any age or treatment group. The percentage of fat mass was significantly increased at 13 and 16 months of age but was reduced by ovarian transplantation in 16-month-old mice. The percentages of lean body mass and total body water were significantly reduced in 13-month-old control mice but were restored in 16- and 25-month-old recipient mice by ovarian transplantation to the levels found in six-month-old control mice. In summary, we have shown that skeletal muscle mass, which is negatively influenced by aging, can be positively influenced or restored by reestablishment of active ovarian function in aged female mice. These findings provide strong incentive for further investigation of the positive influence of young ovaries on restoration of health in postreproductive females. PMID:27747096

  4. Manipulation of Ovarian Function Significantly Influenced Sarcopenia in Postreproductive-Age Mice

    Directory of Open Access Journals (Sweden)

    Rhett L. Peterson

    2016-01-01

    Full Text Available Previously, transplantation of ovaries from young cycling mice into old postreproductive-age mice increased life span. We anticipated that the same factors that increased life span could also influence health span. Female CBA/J mice received new (60 d ovaries at 12 and 17 months of age and were evaluated at 16 and 25 months of age, respectively. There were no significant differences in body weight among any age or treatment group. The percentage of fat mass was significantly increased at 13 and 16 months of age but was reduced by ovarian transplantation in 16-month-old mice. The percentages of lean body mass and total body water were significantly reduced in 13-month-old control mice but were restored in 16- and 25-month-old recipient mice by ovarian transplantation to the levels found in six-month-old control mice. In summary, we have shown that skeletal muscle mass, which is negatively influenced by aging, can be positively influenced or restored by reestablishment of active ovarian function in aged female mice. These findings provide strong incentive for further investigation of the positive influence of young ovaries on restoration of health in postreproductive females.

  5. Assessment of Telomere Length in Archived Formalin-Fixed, Paraffinized Human Tissue Is Confounded by Chronological Age and Storage Duration

    Science.gov (United States)

    2016-01-01

    Telomeres shorten with physiological aging but undergo substantial restoration during cancer immortalization. Increasingly, cancer studies utilize the archive of formalin-fixed, paraffin-embedded (FFPE) tissues in diagnostic pathology departments. Conceptually, such studies would be confounded by physiological telomere attrition and loss of DNA integrity from prolonged tissue storage. Our study aimed to investigate these two confounding factors. 145 FFPE tissues of surgically-resected, non-diseased appendixes were retrieved from our pathology archive, from years 2008 to 2014. Cases from 2013 to 2014 were categorized by patient chronological age (0–20 years, 21–40 years, 41–60 years, > 60 years). Telomere lengths of age categories were depicted by telomere/chromosome 2 centromere intensity ratio (TCR) revealed by quantitative fluorescence in situ hybridization. Material from individuals aged 0–20 years from years 2013/2014, 2011/2012, 2009/2010, and 2008 were compared for storage effect. Telomere integrity was assessed by telomere fluorescence intensity (TFI). Epithelial TCRs (mean ± SD) for the respective age groups were 4.84 ± 2.08, 3.64 ± 1.21, 2.03 ± 0.37, and 1.93 ± 0.45, whereas corresponding stromal TCRs were 5.16 ± 2.55, 3.84 ± 1.36, 2.49 ± 1.20, and 2.93 ± 1.24. A trend of inverse correlation with age in both epithelial and stromal tissues is supported by r = -0.69, p archived beyond 2 years are suboptimal for telomere analysis. PMID:27598341

  6. Home-based Early Intervention on Auditory and Speech Development in Mandarin-speaking Deaf Infants and Toddlers with Chronological Aged 7–24 Months

    Directory of Open Access Journals (Sweden)

    Ying Yang

    2015-01-01

    Conclusions: The data suggested the early hearing intervention and home-based habilitation benefit auditory and speech development. Chronological age and recovery time may be major factors for aural verbal outcomes in hearing impaired children. The development of auditory and speech in hearing impaired children may be relatively crucial in thefirst year's habilitation after fitted with the auxiliary device.

  7. Mechanisms of chemotherapy-induced human ovarian aging: double strand DNA breaks and microvascular compromise

    OpenAIRE

    Soleimani, Reza; Heytens, Elke; Darzynkiewicz, Zbigniew; Oktay, Kutluk

    2011-01-01

    The mechanism of chemotherapy-induced acceleration of ovarian aging is not fully understood. We used doxorubicin, a widely used cancer chemotherapeutic, in a variety of in vivo xenograft, and in vitro models to investigate the impact of chemotherapy-induced aging on the human ovary. Doxorubicin caused massive double-strand-DNA-breaks in primordial follicles, oocytes, and granulosa cells in a dose dependent fashion as revealed by accumulating γH2AX foci. This damage was associated with apoptot...

  8. Social Recognition Memory: Influence of Age, Sex, and Ovarian Hormonal Status

    OpenAIRE

    Markham, Julie A.; Juraska, Janice M.

    2007-01-01

    Social recognition memory underlies many forms of rodent interaction and can be easily tested in the laboratory. Sex differences in aspects of this memory have been reported among young adults, and some studies indicate an age-related decline among male rats. In contrast, neither the impact of natural fluctuations in ovarian hormones nor the performance of aged female rats on social recognition memory has been previously evaluated. In experiments 1 and 2, the social recognition memory of youn...

  9. Changes in anti-Mullerian hormone serum concentrations over time suggest delayed ovarian ageing in normogonadotrophic anovulatory infertility

    NARCIS (Netherlands)

    Mulders, AGMGJ; Laven, JSE; Eijkemans, MJC; de Jong, FH; Themmen, APN; Fauser, BCJM

    2004-01-01

    BACKGROUND: Anti-Mullerian hormone (AMH), produced by growing pre-antral and early antral ovarian follicles, has been shown to be a useful marker for ovarian ageing. Serum AMH concentrations are elevated during reproductive life in anovulatory women, especially in those patients exhibiting polycysti

  10. Radiographic evaluation of third-molar development in relation to the chronological age of Turkish children in the southwest Eastern Anatolia region.

    Science.gov (United States)

    Karataş, Orhan H; Öztürk, Fırat; Dedeoğlu, Numan; Çolak, Cemil; Altun, Oğuzhan

    2013-10-10

    To study the chronological age of third-molar mineralisation of Turkish children from the southwest Eastern Anatolia region, the Demirjian staging method was used to determine the stage of the mineralisation of four third molars (18, 28, 38 and 48) and to compare third-molar development by sex and age with the results of previous studies. The study comprised 832 Turkish children from the southwest Eastern Anatolia region aged 6-16 years based on radiological evidence from digital orthopantomograms. The mean age of the 832 patients was 11.03±1.98 years, with 424 males (mean age, 10.97±1.97) and 408 females (mean age, 11.09±2.00). The orthopantomograms were scored by two observers. The Wilcoxon matched-pairs signed-rank test used to assess intra- and inter-observer assessment revealed strong agreement between both observers' measurements. Statistical analysis of the association between sex and age was performed with the Mann-Whitney U-test and the Wilcoxon test. Regression analysis was performed to obtain regression formulae for calculating the dental and the chronological age. The statistical analysis showed a strong correlation between age and third-molar development in males (R(2)=0.61) and females (R(2)=0.63). New equations (age=7.49+0.69, development stage (DS) 38+0.70, DS18) were derived for estimation of the chronological age. The results showed that there was no significant difference in mineralisation between 18 and 28 and 38 and 48 in males or females. For both sexes, the dental age was lower than the chronological age. Males reached the developmental stages earlier than females. In the whole population, the boys' and the girls' dental ages were 0.84 years and 0.16 years earlier, respectively, than their chronological ages. The use of third-molar teeth as a developmental marker is suitable, particularly when comparing the obtained standard deviation with other skeletal-age calculation techniques.

  11. An in vivo study on brain microstructure in biological and chronological ageing

    DEFF Research Database (Denmark)

    Altmann-Schneider, Irmhild; de Craen, Anton J M; van den Berg-Huysmans, Annette A;

    2015-01-01

    phenotype of familial longevity. Moreover, we aimed to describe cerebral ageing effects on MTI parameters in an elderly cohort. All subjects were included from the Leiden Longevity Study and underwent 3 Tesla MTI of the brain. In total, 183 offspring of nonagenarian siblings, who are enriched for familial...

  12. Melatonin improves age-induced fertility decline and attenuates ovarian mitochondrial oxidative stress in mice

    Science.gov (United States)

    Song, Chao; Peng, Wei; Yin, Songna; Zhao, Jiamin; Fu, Beibei; Zhang, Jingcheng; Mao, Tingchao; Wu, Haibo; Zhang, Yong

    2016-01-01

    Increasing evidence shows that melatonin protected against age-related mitochondrial oxidative damage. However, the protective effects of melatonin against ovarian aging has not been explored. Young Kunming females (aged 2–3 months) were fed with melatonin added to drinking water for 6 or 12 months (mo). We found that long-term (12 mo) melatonin treatment significantly reduced ovarian aging, as indicated by substantial increases in litter size, pool of follicles, and telomere length as well as oocyte quantity and quality. Melatonin treatment suppressed ovarian mitochondrial oxidative damage by decreasing mitochondrial reactive oxygen species (mROS) generation, inhibiting apoptosis, repressing collapse of mitochondrial membrane potential and preserving respiratory chain complex activities. Female mice fed with melatonin had enhanced mitochondrial antioxidant activities, thus reducing the risk of mitochondrial oxidative damage cause by free radicals. Notably, melatonin treatment enhanced SIRT3 activity but not the protein expression level, and increased the binding affinity of FoxO3a to the promoters of both superoxide dismutase 2 (SOD2) and catalase (CAT). In conclusion, melatonin exerted protection against aging-induced fertility decline and maintenance of mitochondrial redox balance. PMID:27731402

  13. Lunar basalt chronology, mantle differentiation and implications for determining the age of the Moon

    Science.gov (United States)

    Snape, Joshua F.; Nemchin, Alexander A.; Bellucci, Jeremy J.; Whitehouse, Martin J.; Tartèse, Romain; Barnes, Jessica J.; Anand, Mahesh; Crawford, Ian A.; Joy, Katherine H.

    2016-10-01

    Despite more than 40 years of studying Apollo samples, the age and early evolution of the Moon remain contentious. Following the formation of the Moon in the aftermath of a giant impact, the resulting Lunar Magma Ocean (LMO) is predicted to have generated major geochemically distinct silicate reservoirs, including the sources of lunar basalts. Samples of these basalts, therefore, provide a unique opportunity to characterize these reservoirs. However, the precise timing and extent of geochemical fractionation is poorly constrained, not least due to the difficulty in determining accurate ages and initial Pb isotopic compositions of lunar basalts. Application of an in situ ion microprobe approach to Pb isotope analysis has allowed us to obtain precise crystallization ages from six lunar basalts, typically with an uncertainty of about ± 10 Ma, as well as constrain their initial Pb-isotopic compositions. This has enabled construction of a two-stage model for the Pb-isotopic evolution of lunar silicate reservoirs, which necessitates the prolonged existence of high-μ reservoirs in order to explain the very radiogenic compositions of the samples. Further, once firm constraints on U and Pb partitioning behaviour are established, this model has the potential to help distinguish between conflicting estimates for the age of the Moon. Nonetheless, we are able to constrain the timing of a lunar mantle reservoir differentiation event at 4376 ± 18 Ma, which is consistent with that derived from the Sm-Nd and Lu-Hf isotopic systems, and is interpreted as an average estimate of the time at which the high-μ urKREEP reservoir was established and the Ferroan Anorthosite (FAN) suite was formed.

  14. Beneficial modulation from a high-purity caviar-derived homogenate on chronological skin aging.

    Science.gov (United States)

    Marotta, Francesco; Polimeni, Ascanio; Solimene, Umberto; Lorenzetti, Aldo; Minelli, Emilio; Jain, Shalini; Rastmanesh, Reza; Sedriep, Sonia; Soresi, Vincenzo

    2012-04-01

    This study tested the activity of LD-1227, which contains a caviar-derived homogenate added with coenzyme Q(10) (CoQ(10))-selenium component (CaviarLieri(®), Lab-Dom, Switzerland), in aged human skin and its potential role on skin mitochondria function. Human dermal fibroblasts were obtained from healthy donors over 70 years old and treated with LD-1227 for 72 hr. As compared to baseline, LD-1227 caused a robust (>67%) collagen type I synthesis (pbeneficially affect mitochondrial function. PMID:22533426

  15. Stratification of yeast cells during chronological aging by size points to the role of trehalose in cell vitality.

    Science.gov (United States)

    Svenkrtova, Andrea; Belicova, Lenka; Volejnikova, Andrea; Sigler, Karel; Jazwinski, S Michal; Pichova, Alena

    2016-04-01

    Cells of the budding yeast Saccharomyces cerevisiae undergo a process akin to differentiation during prolonged culture without medium replenishment. Various methods have been used to separate and determine the potential role and fate of the different cell species. We have stratified chronologically-aged yeast cultures into cells of different sizes, using centrifugal elutriation, and characterized these subpopulations physiologically. We distinguish two extreme cell types, very small (XS) and very large (L) cells. L cells display higher viability based on two separate criteria. They respire much more actively, but produce lower levels of reactive oxygen species (ROS). L cells are capable of dividing, albeit slowly, giving rise to XS cells which do not divide. L cells are more resistant to osmotic stress and they have higher trehalose content, a storage carbohydrate often connected to stress resistance. Depletion of trehalose by deletion of TPS2 does not affect the vital characteristics of L cells, but it improves some of these characteristics in XS cells. Therefore, we propose that the response of L and XS cells to the trehalose produced in the former differs in a way that lowers the vitality of the latter. We compare our XS- and L-fraction cell characteristics with those of cells isolated from stationary cultures by others based on density. This comparison suggests that the cells have some similarities but also differences that may prove useful in addressing whether it is the segregation or the response to trehalose that may play the predominant role in cell division from stationary culture.

  16. Age and dynamics of the Namib Sand Sea: A review of chronological evidence and possible landscape development models

    Science.gov (United States)

    Stone, A. E. C.

    2013-06-01

    The Namib Sand Sea constitutes a major physiographic feature of the Namib Desert on the west of Namibia, covering a 50-160 km wide region of the coast between Lüderitz and Walvis Bay. It is widely considered to be one of the oldest desert regions, with a Tertiary-aged fossil desert underlying the modern sand sea. The sand sea has been well studied, benefiting from the presence of the Gobabeb Training and Research Centre during the past 50 years. Whilst much is understood about its sediments and geomorphology, it is only recently that new chronological information, using cosmogenic-nuclide burial dating and optically stimulated luminescence dating have offered new insights, and this calls for an updated review of the age and landscape development of the sand sea. This assessment of the geomorphological and Quaternary dynamics of the region is complemented by developments in the description and analysis of sediment composition. New age control from cosmogenic dating indicates that the sand sea is in excess of a million years old. Initial data from luminescence dating yields depositional ages for dune sediments from three broad areas of the sand sea that include MIS 5, later in the Pleistocene around the Last Glacial Maximum and the Holocene, although it is not expected that these will be the only, or discrete age groupings. Detailed dating and application of ground penetrating radar in the far northern reaches reveals extensive dune migration and deposition during the Holocene. It is important to stress that the upper limit of luminescence dating here is about ˜200 ka (depending on the environmental dose rate of the site) and that migration and reworking of dunes resets the luminescence signal (so what is recorded is(are) the last phase(s) of preserved sediment accumulation). Whilst there are three potential sources of material for the Namib Sand Sea (reworked Tsondab Sandstone (TSS), material from the Great Escarpment derived by rivers and water and wind

  17. Removal of ovarian hormones affects the ageing process of acetate metabolism

    Directory of Open Access Journals (Sweden)

    Yoshihisa Urita

    2009-01-01

    Full Text Available Background : Despite a close association between gastrointestinal motility and sex hormones, it has been unknown whether ovarian hormones affect absorption and metabolism of nutrients. The aim of this study is, therefore, to evaluate metabolism of acetate in rats with age and the influence of ovariectomy on its change. M ethods : Fourteen female rats of the F344 strain were used, and 13C-acetate breath test was performed at 2, 7 and 13 months of age. Seven rats were ovariectomized at three weeks of age (ovariectomy group and the remaining seven rats were studied as control group. After 24-hr fasting, rats are orally administrated 1ml of water containing sodium 13C-acetate (100mg/kg and housed in an animal chamber. The expired air in the chamber is collected in a breath-sampling bag using a aspiration pump. The 13CO2 concentration is measured using an infrared spectrometer for 120 min and expressed as delta per mil. Results : The breath 13CO2 excretion increased with time and peaked 30 min in control rats. In ovariectomized rats, thee peak time of 13CO2 excretion was prolonged to 40 min at 7 and 13 months of age. Cmax was significantly higher at 2 months of age but lower at 4 months of age in ovariectomized rats than in control rats. Those of two groups became equal at 7 months of age. Conclusions : From the viewpoint of acetate metabolism, removal of ovarian hormones might make rats to be precocious ones and accelerate ageing. (Urita Y, Watanabe T, Imai T, Yasuyuki Miura Y, Washizawa N, Masaki Sanaka M, Nakajima H, Sugimoto M. Removal of ovarian hormones affects the ageing process of acetate metabolism.

  18. Age at menarche as a predictor of diminished ovarian reserve: a new approach

    OpenAIRE

    Ramona Perhar; Rita Shukla; Akanksha Mishra

    2015-01-01

    Background: Objective of current study was to investigate whether age at menarche is associated with Functional Ovarian Reserve (FOR) later in life. Methods: Design: Retrospective cohort study. Setting: Gayatri Hospital, Allahabad, Uttar Pradesh, India. Patient(s): One hundred fifty one. Intervention(s): None. Results: The mean age of the patients was 38.9 +/- 4.9 years, and their mean level of AMH was 1.4 +/- 2.0 ng/ml and of FSH was 10.7 +/- 6.1 mIU/ml. Their current age-specific Dim...

  19. Impact of physical activity on ovarian reserve markers in normal, overweight and obese reproductive age women.

    Science.gov (United States)

    Surekha, T; Himabindu, Y; Sriharibabu, M; Pandey, Anil Kumar

    2014-01-01

    Physical inactivity is a leading risk factor for overweight and obesity in the society. Prevalence of overweight and obesity in the reproductive age group women not only affects maternal health but also the health of the off spring. Infertility is a common problem in India affecting 13-19 million people at any given time. Even though it is not life threatening, infertility causes intense mental agony and trauma that can only be best described by infertile couples themselves. Infertility is more common in overweight and obese individuals compared to normal weight individuals. Decreasing ovarian reserve is an important factor for infertility in women. This study examined the impact of physical activity on ovarian reserve markers in normal, overweight and obese reproductive age women. The observations made in this study reveal that physical activity improves ovarian reserve markers in all reproductive age women but this improvement is more distinct and statistically significant in overweight and obese women compared to normal weight women. PMID:25509968

  20. Testing ovarian reserve to predict age at menopause

    NARCIS (Netherlands)

    C.B. Lambalk; J. van Disseldorp; C.H. de Konig; F.J. Broekmans

    2009-01-01

    In modern society with women delaying pregnancy, predicting the age of the natural menopause with its preceding infertility will allow making informed choices about when to try starting to have children. Also if premature menopause could be predicted in young women, strategies could be instigated to

  1. Longitudinal study of dental development in chimpanzees of known chronological age: implications for understanding the age at death of Plio-Pleistocene hominids.

    Science.gov (United States)

    Anemone, R L; Mooney, M P; Siegel, M I

    1996-01-01

    Reconstruction of life history variables of fossil hominids on the basis of dental development requires understanding of and comparison with the pattern and timing of dental development among both living humans and pongids. Whether dental development among living apes or humans provides a better model for comparison with that of Plio-Pleistocene hominids of the genus Australopithecus remains a contentious point. This paper presents new data on chimpanzees documenting developmental differences in the dentitions of modern humans and apes and discusses their significance in light of recent controversies over the human or pongid nature of australopithecine dental development. Longitudinal analysis of 299 lateral head radiographs from 33 lab-reared chimpanzees (Pan troglodytes) of known chronological age allows estimation of means and standard deviations for the age at first appearance of 8 developmental stages in the mandibular molar dentition. Results are compared with published studies of dental development among apes and with published standards for humans. Chimpanzees are distinctly different from humans in two important aspects of dental development. Relative to humans, chimpanzees show advanced molar development vis a vis anterior tooth development, and chimpanzees are characterized by temporal overlap in the calcification of adjacent molar crowns, while humans show moderate to long temporal gaps between the calcification of adjacent molar crowns. In combination with recent work on enamel incremental markers and CAT scans of developing dentitions of Plio-Pleistocene hominids, this evidence supports an interpretation of a rapid, essentially "apelike" ontogeny among australopithecines. PMID:8928715

  2. Removal of ovarian hormones affects the ageing process of acetate metabolism

    Directory of Open Access Journals (Sweden)

    Tsunehiko Imai

    2009-07-01

    Full Text Available Background: Despite a close association between gastrointestinal motility and sex hormones, it has been unknown whether ovarian hormones affect absorption and metabolism of nutrients. The aim of this study is, therefore, to evaluate metabolism of acetate in rats with age and the influence of ovariectomy on its change. Methods: Fourteen female rats of the F344 strain were used, and 13C-acetate breath test was performed at 2, 7 and 13 months of age. Seven rats were ovariectomized at three weeks of age (ovariectomy group and the remaining seven rats were studied as control group. After 24-hr fasting, rats are orally administrated 1ml of water containing sodium 13C-acetate (100mg/kg and housed in an animal chamber. The expired air in the chamber is collected in a breath-sampling bag using a aspiration pump. The 13CO2 concentration is measured using an infrared spectrometer for 120 min and expressed as delta per mil. Results: The breath 13CO2 excretion increased with time and peaked 30 min in control rats. In ovariectomized rats, thee peak time of 13CO2 excretion was prolonged to 40 min at 7 and 13 months of age. Cmax was significantly higher at 2 months of age but lower at 4 months of age in ovariectomized rats than in control rats. Those of two groups became equal at 7 months of age. Conclusions: From the viewpoint of acetate metabolism, removal of ovarian hormones might make rats to be precocious ones and accelerate ageing.

  3. A new clinically applicable age-specific comorbidity index for preoperative risk assessment of ovarian cancer patients

    DEFF Research Database (Denmark)

    Noer, Mette Calundann; Sperling, Cecilie Dyg; Antonsen, Sofie Leisby;

    2016-01-01

    OBJECTIVE: To develop and validate a new feasible comorbidity index based on self-reported information suited for preoperative risk assessment of ovarian cancer patients. METHODS: The study was based on patient self-reported data from ovarian cancer patients registered in the Danish Gynecological....... CONCLUSION: This new age-specific comorbidity index based on self-reported information is a significant predictor of overall and cancer-specific survival in ovarian cancer. It can be used to quickly identify those ovarian cancer patients requiring special attention in terms of preoperative optimization...... survival in the development cohort, and regression coefficients were used to construct a new weighted comorbidity index. The index was applied to the validation cohort, and its predictive ability in regard to overall and cancer-specific five-year-survival was investigated. Finally, the performance...

  4. Age at menarche as a predictor of diminished ovarian reserve: a new approach

    Directory of Open Access Journals (Sweden)

    Ramona Perhar

    2015-02-01

    Methods: Design: Retrospective cohort study. Setting: Gayatri Hospital, Allahabad, Uttar Pradesh, India. Patient(s: One hundred fifty one. Intervention(s: None. Results: The mean age of the patients was 38.9 +/- 4.9 years, and their mean level of AMH was 1.4 +/- 2.0 ng/ml and of FSH was 10.7 +/- 6.1 mIU/ml. Their current age-specific Diminished Functional Ovarian Reserve (DFOR was statistically significantly associated with early menarche, defined as age 75th percentile. Conclusions: The study demonstrates a statistically significant impact of menarche on DFOR risk later in life among infertile women. The occurrence of menarche may relate to follicular pool size and/or speed of follicle recruitment, which in turn, is predictive of occurrence of DFOR later in life. [Int J Reprod Contracept Obstet Gynecol 2015; 4(1.000: 235-238

  5. Differential Expression of Claudin Family Proteins in Mouse Ovarian Serous Papillary Epithelial Adenoma in Aging FSH Receptor-Deficient Mutants

    Directory of Open Access Journals (Sweden)

    Jayaprakash Aravindakshan

    2006-12-01

    Full Text Available Ovarian cancer is a deadly disease with long latency. To understand the consequences of loss of folliclestimulating hormone receptor (FSH-R signaling and to explore why the atrophic and anovulatory ovaries of follitropin receptor knockout (FORKO mice develop different types of ovarian tumors, including serous papillary epithelial adenoma later in life, we used mRNA expression profiling to gain a comprehensive view of misregulated genes. Using real-time quantitative reverse transcription-polymerase chain reaction, protein analysis, and cellular localization, we show, for the first time, in vivo evidence that, in the absence of FSH-R signaling, claudin-3, claudin-4, and claudin-11 are selectively upregulated, whereas claudin-1 decreases in ovarian surface epithelium and tumors in comparison to wild type. In vitro experiments using a mouse ovarian surface epithelial cell line derived from wild-type females reveal direct hormonal influence on claudin proteins. Although recent studies suggest that cell junction proteins are differentially expressed in ovarian tumors in women, the etiology of such changes remains unclear. Our results suggest an altered hormonal environment resulting from FSH-R loss as a cause of early changes in tight junction proteins that predispose the ovary to late-onset tumors that occur with aging. More importantly, this study identifies claudin-11 overexpression in mouse ovarian serous cystadenoma.

  6. Home-based Early Intervention on Auditory and Speech Development in Mandarin-speaking Deaf Infants and Toddlers with Chronological Aged 7-24 Months

    Institute of Scientific and Technical Information of China (English)

    Ying Yang; Yue-Hui Liu; Ming-Fu Fu; Chun-Lin Li; Li-Yan Wang; Qi Wang; Xi-Bin Sun

    2015-01-01

    Background:Early auditory and speech development in home-based early intervention of infants and toddlers with hearing loss younger than 2 years are still spare in China.This study aimed to observe the development of auditory and speech in deaf infants and toddlers who were fitted with hearing aids and/or received cochlear implantation between the chronological ages of 7-24 months,and analyze the effect of chronological age and recovery time on auditory and speech development in the course of home-based early intervention.Methods:This longitudinal study included 55 hearing impaired children with severe and profound binaural deafness,who were divided into Group A (7-12 months),Group B (13-18 months) and Group C (19-24 months) based on the chronological age.Categories auditory performance (CAP) and speech intelligibility rating scale (SIR) were used to evaluate auditory and speech development at baseline and 3,6,9,12,18,and 24 months of habilitation.Descriptive statistics were used to describe demographic features and were analyzed by repeated measures analysis of variance.Results:With 24 months of hearing intervention,78% of the patients were able to understand common phrases and conversation without lip-reading,96% of the patients were intelligible to a listener.In three groups,children showed the rapid growth of trend features in each period of habilitation.CAP and SIR scores have developed rapidly within 24 months after fitted auxiliary device in Group A,which performed much better auditory and speech abilities than Group B (P < 0.05) and Group C (P < 0.05).Group B achieved better results than Group C,whereas no significant differences were observed between Group B and Group C (P > 0.05).Conclusions:The data suggested the early hearing intervention and home-based habilitation benefit auditory and speech development.Chronological age and recovery time may be major factors for aural verbal outcomes in hearing impaired children.The development of auditory

  7. (UnResolved contradictions in the Late Pleistocene glacial chronology of the Southern Carpathians - new samples and recalculated cosmogenic radionuclide age estimates

    Directory of Open Access Journals (Sweden)

    Zsófia RUSZKICZAY-RÜDIGER

    2014-11-01

    Full Text Available Application of cosmogenic nuclides in the study of Quaternary glaciations has increased rapidly during the last decade owing to the previous absence of direct dating methods of glacial landforms and sediments. Although several hundred publications have already been released on exposure age dating of glacial landforms worldwide, very few studies targeted the Carpathians so far (Kuhlemann et al, 2013a; Makos et al., 2014; Reuther et al, 2004, 2007; Rinterknecht et al. 2012.There are many unresolved or contradictory issues regarding the glacial chronology of the Romanian Carpathians. Recently, some attempts have been made to develop an improved temporal framework for the glaciations of the region using cosmogenic 10Be dating (Reuther et al. 2004, 2007, Kuhlemann et al. 2013a. However, these studies made the picture even more confusing because the local last glacial maximum, for instance, apparently occurred in asynchronous timing compared to each other and also to other dated glacial events in Europe (Hughes et al, 2013.This situation is even more interesting if we take into account that the local glacial maximum tends to agree with the global LGM derived from the Eastern Balkans (Kuhlemann et al. 2013b, while the penultimate glaciation seems to significantly overtake the LGM advance over the Western Balkans (Hughes et al. 2011.The primary candidate reasons to resolve these discrepancies are methodological, e.g. insufficient number of samples (one sample/landform ignoring geological scatter of the data and the application of different half-lives, production rates and scaling schemes during the calculation of exposure ages. Systematic methodological uncertainties in computing exposure ages from measured nuclide concentrations have a significant impact on the conclusions concerning correlations of exposure-dated glacier chronologies with millennial scale climate changes (Balco, 2011. The changes in glacial timing generated by only using the most

  8. Pioglitazone administration alters ovarian gene expression in aging obese lethal yellow mice

    Directory of Open Access Journals (Sweden)

    Weber Mitch

    2008-03-01

    Full Text Available Abstract Background Women with polycystic ovary syndrome (PCOS are often treated with insulin-sensitizing agents, e.g. thiazolidinediones (TZD, which have been shown to reduce androgen levels and improved ovulatory function. Acting via peroxisome proliferator-activated receptor (PPAR gamma, TZD alter the expression of a large variety of genes. Lethal yellow (LY; C57BL/6J Ay/a mice, possessing a mutation (Ay in the agouti gene locus, exhibit progressive obesity, reproductive dysfunction, and altered metabolic regulation similar to women with PCOS. The current study was designed to test the hypothesis that prolonged treatment of aging LY mice with the TZD, pioglitazone, alters the ovarian expression of genes that may impact reproduction. Methods Female LY mice received daily oral doses of either 0.01 mg pioglitazone (n = 4 or an equal volume of vehicle (DMSO; n = 4 for 8 weeks. At the end of treatment, ovaries were removed and DNA microarrays were used to analyze differential gene expression. Results Twenty-seven genes showed at least a two-fold difference in ovarian expression with pioglitazone treatment. These included leptin, angiopoietin, angiopoietin-like 4, Foxa3, PGE1 receptor, resistin-like molecule-alpha (RELM, and actin-related protein 6 homolog (ARP6. For most altered genes, pioglitazone changed levels of expression to those seen in untreated C57BL/6J(a/a non-mutant lean mice. Conclusion TZD administration may influence ovarian function via numerous diverse mechanisms that may or may not be directly related to insulin/IGF signaling.

  9. Division of labor is associated with age-independent changes in ovarian activity in Pogonomyrmex californicus harvester ants.

    Science.gov (United States)

    Dolezal, Adam G; Johnson, Joshua; Hölldobler, Bert; Amdam, Gro V

    2013-04-01

    An age-independent division of labor can develop in both the reproductive (queen) and non-reproductive (worker) castes of Pogonomyrmex californicus harvester ants, and individuals develop biases for in-nest activities or external foraging. Additionally, ant ovaries normally atrophy in foragers compared to nest-biased workers (nurses). However, it is not clear whether these ovarian changes are due to changes in behavior or age, since foragers are typically older individuals. Here, we clarify this relationship in P. californicus queens and workers by comparing ovarian activity in same-aged ants that exhibit divergent behavioral biases. We found that foraging individuals had significantly reduced ovarian activity compared to their nest-biased counterparts, thereby linking changes in the ants' reproductive system to social task performance rather than to age. The general finding that ovarian physiology is associated with social insect behaviors is consistent with the hypothesis that reproductive physiology may have played an important role in the evolution of social insect behavior.

  10. Threat of fertility loss in cancer patients of reproductive age and the current feasibilities of ovarian tissue cryopreservation

    Directory of Open Access Journals (Sweden)

    A. A. Parokonnaya

    2010-01-01

    Full Text Available To solve the problem of preserving reproductive function in cancer patients is very urgent today because antitumor treatment comprising different combinations of radio- and chemotherapy and surgery lead to ovarian reserve depletion and premature menopause in repro- ductive-aged women. The authors propose to consider one of the fertility preservation techniques – ovarian tissue cryopreservation. A procedure for cryopreservation is described in detail; its efficiency is evaluated. In the authors’ opinion, this procedure is one of most promising in preserving the sexual material of cancer patients.

  11. A New Predictor AMH (anti-müllerian hormone to Determining Ovarian Reserve and Menoposual Aging in the Women

    Directory of Open Access Journals (Sweden)

    Levent Sarýyýldýz

    2013-05-01

    Full Text Available       Anti-mullerian hormone (AMH, also termed Mullerian inhibiting substance (MIS, is produced in ovary by granulose cells and known as a member of the TGF- β superfamily. The researchers imply that AMH is associated with the various growth factors in development and growth of ovarian follicles, furthermore  is exhibited the features of other TGF-β family members. AMH has a critical importance in reproductive age of women. Certain standardization has not yet been developed in determing the ovarian reserve. Recent findings reveal the importance of AMH in determining ovary function and, highlight the importance of AMH than FSH.

  12. New luminescence ages for the Galeria Complex archaeological site: resolving chronological uncertainties on the acheulean record of the Sierra de Atapuerca, northern Spain.

    Directory of Open Access Journals (Sweden)

    Martina Demuro

    Full Text Available The archaeological karstic infill site of Galería Complex, located within the Atapuerca system (Spain, has produced a large faunal and archaeological record (Homo sp. aff. heidelbergensis fossils and Mode II lithic artefacts belonging to the Middle Pleistocene. Extended-range luminescence dating techniques, namely post-infrared infrared stimulated luminescence (pIR-IR dating of K-feldspars and thermally transferred optically stimulated luminescence (TT-OSL dating of individual quartz grains, were applied to fossil-bearing sediments at Galería. The luminescence dating results are in good agreement with published chronologies derived using alternative radiometric dating methods (i.e., ESR and U-series dating of bracketing speleothems and combined ESR/U-series dating of herbivore teeth, as well as biochronology and palaeoenvironmental reconstructions inferred from proxy records (e.g., pollen data. For the majority of samples dated, however, the new luminescence ages are significantly (∼50% younger than previously published polymineral thermoluminescence (TL chronologies, suggesting that the latter may have overestimated the true burial age of the Galería deposits. The luminescence ages obtained indicate that the top of the basal sterile sands (GIb at Galería have an age of up to ∼370 thousand years (ka, while the lowermost sub-unit containing Mode II Acheulean lithics (base of unit GIIa was deposited during MIS 9 (mean age = 313±14 ka; n = 4. The overlying units GIIb-GIV, which contain the richest archaeopalaeontological remains, were deposited during late MIS 8 or early MIS 7 (∼240 ka. Galería Complex may be correlative with other Middle Pleistocene sites from Atapuerca, such as Gran Dolina level TD10 and unit TE19 from Sima del Elefante, but the lowermost archaeological horizons are ∼100 ka younger than the hominin-bearing clay breccias at the Sima de los Huesos site. Our results suggest that both pIR-IR and single-grain TT

  13. New luminescence ages for the Galería Complex archaeological site: resolving chronological uncertainties on the acheulean record of the Sierra de Atapuerca, northern Spain.

    Science.gov (United States)

    Demuro, Martina; Arnold, Lee J; Parés, Josep M; Pérez-González, Alfredo; Ortega, Ana I; Arsuaga, Juan L; Bermúdez de Castro, José M; Carbonell, Eudald

    2014-01-01

    The archaeological karstic infill site of Galería Complex, located within the Atapuerca system (Spain), has produced a large faunal and archaeological record (Homo sp. aff. heidelbergensis fossils and Mode II lithic artefacts) belonging to the Middle Pleistocene. Extended-range luminescence dating techniques, namely post-infrared infrared stimulated luminescence (pIR-IR) dating of K-feldspars and thermally transferred optically stimulated luminescence (TT-OSL) dating of individual quartz grains, were applied to fossil-bearing sediments at Galería. The luminescence dating results are in good agreement with published chronologies derived using alternative radiometric dating methods (i.e., ESR and U-series dating of bracketing speleothems and combined ESR/U-series dating of herbivore teeth), as well as biochronology and palaeoenvironmental reconstructions inferred from proxy records (e.g., pollen data). For the majority of samples dated, however, the new luminescence ages are significantly (∼50%) younger than previously published polymineral thermoluminescence (TL) chronologies, suggesting that the latter may have overestimated the true burial age of the Galería deposits. The luminescence ages obtained indicate that the top of the basal sterile sands (GIb) at Galería have an age of up to ∼370 thousand years (ka), while the lowermost sub-unit containing Mode II Acheulean lithics (base of unit GIIa) was deposited during MIS 9 (mean age = 313±14 ka; n = 4). The overlying units GIIb-GIV, which contain the richest archaeopalaeontological remains, were deposited during late MIS 8 or early MIS 7 (∼240 ka). Galería Complex may be correlative with other Middle Pleistocene sites from Atapuerca, such as Gran Dolina level TD10 and unit TE19 from Sima del Elefante, but the lowermost archaeological horizons are ∼100 ka younger than the hominin-bearing clay breccias at the Sima de los Huesos site. Our results suggest that both pIR-IR and single-grain TT

  14. Chronological objects in demographic research

    NARCIS (Netherlands)

    Willekens, F.J.C.

    2013-01-01

    Background: Calendar time, age and duration are chronological objects. They represent an instant or a time period. Age and duration are usually expressed in units with varying lengths. The number of days in a month or a year depends on the position on the calendar. The units are also not homogeneous

  15. Mink aging is associated with a reduction in ovarian hormone release and the response to FSH and ghrelin.

    Science.gov (United States)

    Sirotkin, Alexander V; Mertin, Dušan; Süvegová, Karina; Lauričik, Jozef; Morovič, Martin; Harrath, Abdel Halim; Kotwica, Jan

    2016-09-15

    The endocrine mechanisms of mink ovarian hormones release and reproductive aging are poorly investigated. The aims of our study were to: (1) identify hormones produced by mink ovaries (the steroids progesterone [P] and estradiol [E], the peptide hormone oxytocin [OT], and the prostaglandin F [PGF] and prostaglandin E [PGE]); (2) examine the effect of FSH and ghrelin on the release of the hormones listed previously; and (3) understand whether these hormones can be involved in the control of mink reproductive aging, i.e., whether aging can be associated with changes (a) in the basal release of P, E, OT, PGF, or PGE and (b) their response to FSH and ghrelin. Fragments of ovaries of young (yearlings) and old (3-5 years of age) minks were cultured with and without FSH and ghrelin (0, 1, 10, or 100 ng/mL), and the release of hormones was analyzed by EIA/RIA. We found that isolated ovaries were able to release P, E, OT, PGF, and PGE, and the levels of P produced in the ovaries of old animals were lower than those produced in the ovaries of young animals, whereas the levels of other hormones did not differ. FSH was able to stimulate P and E and suppress OT and PGF and did not affect PGE release. Aging was associated with the inhibition of the effect of FSH on ovarian P and E, the appearance of the inhibitory action of FSH on OT, and the disappearance of this action on ovarian PGF. PGE was not affected by FSH, irrespective of animal age. Ghrelin was able to promote E (but not P) and suppress OT, PGF, and PGE output. Aging was associated with the appearance of an inhibitory influence of ghrelin on ovarian OT and PGE and with the disappearance of this influence on PGF output. Aging did not affect the action of ghrelin on ovarian P and E. Our observations (1) confirm the production of P and E and show that OT, PGF, and PGE are released from mink ovaries, (2) confirm the involvement of FSH and demonstrate the involvement of ghrelin in the control of mink ovarian hormone

  16. Impact of female age and male infertility on ovarian reserve markers to predict outcome of assisted reproduction technology cycles

    Directory of Open Access Journals (Sweden)

    Hsieh Kung-Chen

    2009-09-01

    Full Text Available Abstract Background This study was designed to assess the capability of ovarian reserve markers, including baseline FSH levels, baseline anti-Müllerian hormone (AMH levels, and antral follicle count (AFC, as predictors of live births during IVF cycles, especially for infertile couples with advanced maternal age and/or male factors. Methods A prospective cohort of 336 first IVF/ICSI cycles undergoing a long protocol with GnRH agonist was investigated. Patients with endocrine disorders or unilateral ovaries were excluded. Results Among the ovarian reserve tests, AMH and age had a greater area under the receiving operating characteristic curve than FSH in predicting live births. Furthermore, AMH and age were the sole predictive factors of live births for women greater than or equal to 35 years of age; while AMH was the major determinant of live births for infertile couples with absence of male factors by multivariate logistic regression analysis. However, all the studied ovarain reserve tests were not preditive of live births for women Conclusion The serum AMH levels were prognostic for pregnancy outcome for infertile couples with advanced female age or absence of male factors. The predictive capability of ovarian reserve tests is clearly influenced by the etiology of infertility.

  17. Ovarian tumors in pediatric age group - A clinicopathologic study of 10 years′ cases in West Bengal, India

    Directory of Open Access Journals (Sweden)

    Bhattacharyya Nirmal

    2010-01-01

    Full Text Available Background and objectives: Objective in this retrospective study is to find out the incidence of different ovarian tumors of girls up to 20 years of age observed in last ten years in North Bengal Medical College and to correlate clinical and gross findings with histopathologic findings and to compare the incidence with other studies and follow-up of patients with malignant ovarian tumors. Materials and Methods: Findings were retrieved from records of different pathological reports and clinical reports. Results: Total 151 cases of ovarian tumors were received in pathology department in which 34 cases were malignant (22.6%. Amongst malignant cases, 66% are of germ-cell origin-dysgerminoma being the commonest. Strikingly we got 9 cases of malignant surface epithelial tumor. As per follow-up records most of the dysgerminoma came in stage IA and recovered fully following chemotherapy and radiotherapy. Amongst other malignant tumors, few lost the follow-up management and others expired due to metastasis. Conclusions: Patients from hilly areas of North Bengal and low socio-economic status led to lower detection rate of ovarian tumors in early stage which are absolutely necessary for proper guidelines of management to reduce mortality.

  18. Heterozygosity for the classical galactosemia mutation does not affect ovarian reserve and menopausal age

    NARCIS (Netherlands)

    Knauff, Erik A. H.; Richardus, Renate; Eijkemans, Marinus J.; Broekinans, Frank J.; de Jong, Frank J.; Fauser, Bart C. J. M.; Bosch, Annet M.

    2007-01-01

    Female patients with classical galactosemia (galactose-1-phosphate uridyltransferase [GALT] deficiency) frequently suffer from premature ovarian failure, despite treatment with a galactose-restricted diet. Earlier research has suggested an association between heterozygosity for GALT mutations and ea

  19. Epiphyseal maturity indicators at the knee and their relationship to chronological age: results of an Irish population study.

    LENUS (Irish Health Repository)

    O'Connor, Jean E

    2013-09-01

    Skeletal maturation is divisible to three main components; the time of appearance of an ossification center, its change in morphology and time of fusion to a primary ossification center. With regard to the knee, the intermediate period between appearance and fusion of the ossification centers extends over a period of greater than 10 years. This study aims to investigate radiographically the age at which morphological changes of the epiphyses at the knee occur in a modern Irish population. Radiographs of 221 subjects (137 males; 84 females) aged 9-19 years were examined. Seven nonmetric indicators of maturity were assessed using criteria modified from the Roche, Wainer, and Thissen method and Pyle and Hoerr\\'s atlas of the knee. Reference charts are presented which display the timeline for each of the grades of development of the seven indicators. Mean age was found to increase significantly with successive grades of development of each of the seven indicators. A significant difference was noted between males and females at the same grade of development for six of the seven indicators. The narrowest age range reported for a single grade of development was 2.2 years for Grade 2 of development of the tibial tuberosity for males. The information on changing morphology of the epiphyses at the knee in the present study may provide an adjunct to methods used for evaluation of skeletal maturity before surgery for orthopedic disorders or to evaluate skeletal age in clinical scenarios where either delayed or precocious skeletal maturation is suspected.

  20. The Reasons and Prevention of Ovarian Premature Aging%卵巢早衰的原因与预防

    Institute of Scientific and Technical Information of China (English)

    李莉

    2014-01-01

    Objective To analyze the factors that cause ovarian premature aging so as to provide a basis for clinical prevention and treatment of ovarian premature aging. Methods A questionnaire was used to investigate the 100 cases in the observation group and the control group, and the data was treated by logistic regression analysis. Results 12 variables such as the number of induced abortion, drinking, smoking, marital status, family and social relationship, bean products, mood, taking corticosteroids and so on are related to the occurrence of ovarian premature aging. Multiple factors analysis showed that marital status (OR = 6.03), number of induced abortion (OR = 2.14), smoking (OR =3.26), hair coloring (OR =2.74), mood (OR= 0.16), vegetables (OR = 0.34), mumps (OR = 10.23), and other factors are closely associated with ovarian premature aging. Conclusion Many factors can cause ovarian premature aging, so effective measures should be taken clinically to strengthen the prevention and treatment, thereby reducing the incidence of the disease and promoting the recovery of the patients as early as possible.%目的:分析卵巢早衰发生因素,为临床卵巢早衰的防治提供一定的依据。方法采用问卷调查方式对观察组和健康对照组共100例进行logistic回归分析。结果卵巢早衰发生因素与人工流产次数、饮酒、吸烟、婚姻状况以及家人社会相处关系、豆制品、心情和服用糖皮质激素等12个变量相关。多因素分析表明,婚姻状况(OR=6.03)、人工流产次数(OR=2.14)、吸烟(OR=3.26)、染发(OR=2.74)、心情(OR=0.16)、蔬菜(OR=0.34)、腮腺炎(OR=10.23)等因素与卵巢早衰密切相关。结论卵巢早衰发生因素较多,临床应采取有效的措施加强预防,治疗,以降低发病率,促进患者早日康复。

  1. Analysis of ovarian reserve markers (AMH, FSH, AFC) in different age strata in IVF/ICSI patients

    Science.gov (United States)

    Shahrokh Tehraninezhad, Ensieh; Mehrabi, Fatemeh; Taati, Raheleh; Kalantar, Vahid; Aziminekoo, Elham; Tarafdari, Azam

    2016-01-01

    Background: The predictive roles of follicle stimulating hormone (FSH), anti-mullerian hormone (AMH) and antral follicle count (AFC) as ovarian reserve markers in women with different age groups are not established well. Objective: This study compares the value of FSH, AMH and AFC at the time of in vitro fertilization (IVF) treatment in different age groups. Materials and Methods: In this cross-sectional study, 103 women aged 20-43 years candidates for IVF/ICSI cycle were recruited. FSH, AMH and AFC on day 3 of menstrual cycle were measured. The relationship of these measured markers with outcome variables (oocytes number, number of frozen/fresh embryo and chemical and clinical pregnancy) was assessed in different age groups (i.e. 20-32, 33-37 and 38-43 years). Results: our results show that age was correlated with clinical pregnancy, oocyte count and fresh and frozen embryo (p<0.001). AMH, AFC and FSH were not correlated with clinical or chemical pregnancy at total population or age subgroups except the significant correlation of AFC with clinical pregnancy at 33-37 years old group. AFC was correlated with oocyte count and the number of fresh and frozen embryos in the ages group 20-32 years. In this age group, AMH was correlated with fresh and frozen embryos. AMH, AFC and FSH were correlated with oocyte count and the number of fresh embryos in age group 33-37 years. AMH was correlated with oocyte count and the number of fresh embryos in 38-43 years old group. Conclusion: We concluded that the age is the superior predictor of IVF outcome and AMH and AFC are variable predicting markers of ovarian reserve in different age groups. PMID:27679824

  2. Risk prediction for breast, endometrial, and ovarian cancer in white women aged 50 y or older: derivation and validation from population-based cohort studies.

    Directory of Open Access Journals (Sweden)

    Ruth M Pfeiffer

    Full Text Available BACKGROUND: Breast, endometrial, and ovarian cancers share some hormonal and epidemiologic risk factors. While several models predict absolute risk of breast cancer, there are few models for ovarian cancer in the general population, and none for endometrial cancer. METHODS AND FINDINGS: Using data on white, non-Hispanic women aged 50+ y from two large population-based cohorts (the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial [PLCO] and the National Institutes of Health-AARP Diet and Health Study [NIH-AARP], we estimated relative and attributable risks and combined them with age-specific US-population incidence and competing mortality rates. All models included parity. The breast cancer model additionally included estrogen and progestin menopausal hormone therapy (MHT use, other MHT use, age at first live birth, menopausal status, age at menopause, family history of breast or ovarian cancer, benign breast disease/biopsies, alcohol consumption, and body mass index (BMI; the endometrial model included menopausal status, age at menopause, BMI, smoking, oral contraceptive use, MHT use, and an interaction term between BMI and MHT use; the ovarian model included oral contraceptive use, MHT use, and family history or breast or ovarian cancer. In independent validation data (Nurses' Health Study cohort the breast and ovarian cancer models were well calibrated; expected to observed cancer ratios were 1.00 (95% confidence interval [CI]: 0.96-1.04 for breast cancer and 1.08 (95% CI: 0.97-1.19 for ovarian cancer. The number of endometrial cancers was significantly overestimated, expected/observed = 1.20 (95% CI: 1.11-1.29. The areas under the receiver operating characteristic curves (AUCs; discriminatory power were 0.58 (95% CI: 0.57-0.59, 0.59 (95% CI: 0.56-0.63, and 0.68 (95% CI: 0.66-0.70 for the breast, ovarian, and endometrial models, respectively. CONCLUSIONS: These models predict absolute risks for breast, endometrial, and ovarian

  3. Ovarian volume throughout life

    DEFF Research Database (Denmark)

    Kelsey, Thomas W; Dodwell, Sarah K; Wilkinson, A Graham;

    2013-01-01

    cancer. To date there is no normative model of ovarian volume throughout life. By searching the published literature for ovarian volume in healthy females, and using our own data from multiple sources (combined n=59,994) we have generated and robustly validated the first model of ovarian volume from...... to about 2.8 mL (95% CI 2.7-2.9 mL) at the menopause and smaller volumes thereafter. Our model allows us to generate normal values and ranges for ovarian volume throughout life. This is the first validated normative model of ovarian volume from conception to old age; it will be of use in the diagnosis...

  4. Study of ovarian reserve parameters in infertile women of different age groups

    Directory of Open Access Journals (Sweden)

    Umakant Valvekar

    2016-07-01

    Conclusions: Our study results also indicate that serum AMH measurement is better predictor for the number of early antral follicles than conventional hormone measurements. Using AMH measurement in combination with AFC may improve the assessment of ovarian reserve for evaluating the fertility potential and monitoring infertility treatment. [Int J Reprod Contracept Obstet Gynecol 2016; 5(7.000: 2116-2121

  5. A Huge Ovarian Cyst in a Middle-Aged Iranian Female

    Directory of Open Access Journals (Sweden)

    Mohammad Kazem Moslemi

    2010-05-01

    Full Text Available A 38-year-old Iranian woman was found to have a huge ovarian cystic mass. Her presenting symptom was vague abdominal pain and severe abdominal distention. She underwent laparotomy and after surgical removal, the mass was found to be mucinous cystadenoma on histology.

  6. Ovarian antral follicle subclasses and anti-mullerian hormone during normal reproductive aging

    DEFF Research Database (Denmark)

    Bentzen, J G; Forman, J L; Johannsen, T H;

    2013-01-01

    included. Interventions: There were no interventions. MAIN OUTCOME MEASURES: Serum anti-Müllerian hormone (AMH) concentration, antral follicle count (AFC), antral follicle size categories (small: 2-4 mm; intermediate: 5-7 mm; and large: 8-10 mm), and ovarian volume were measured. RESULTS: Serum AMH level...

  7. The Role of Anti-Müllerian Hormone in Ovarian Function, Dysfunction and Aging

    NARCIS (Netherlands)

    M.E. Kevenaar (Maria Elisabeth)

    2008-01-01

    textabstractThe ovary is of major importance for both reproduction and the endocrine status of women. Follicle development in the ovary is regulated by gonadotropins but also by intra-ovarian factors, such as anti-Müllerian hormone (AMH). In mice, AMH inhibits primordial follicle recruitment

  8. Efficacy of intrauterine insemination without ovarian hyperstimulation for male or cervical factor in women aged 40 or over.

    Science.gov (United States)

    Check, J H; Lurie, D; Peymer, M; Katsoff, D; Long, R

    2000-01-01

    The efficacy of intrauterine insemination (IUI) for male or cervical factor by age of female partner was determined in a retrospective analysis. Patients who underwent IUI therapy for cervical and/or male factor (n = 281) were classified by age at first IUI cycle: or =40 years (n = 49). The indication for IUI was cervical factor if a postcoital test failed to show sperm with good forward progression at time of mature follicle; male factor was diagnosed if the semen analysis demonstrated either low count, low motility, antisperm antibodies, or subnormal hypoosmotic swelling test. Intrauterine insemination was performed in either natural cycles or following ovarian stimulation for the treatment of anovulation or follicular maturation defects. Cumulative probability of ongoing pregnancy (viable at end of first trimester) following 3 cycles of IUI was evaluated. Cumulative probability of ongoing pregnancy following 3 cycles of IUI was 28.2% for the younger group and 0.0% for the older group. The age groups did not differ in terms of infertility history, use of ovarian stimulation, or baseline semen parameters. Thus, the treatment of male and/or cervical factor by IUI is ineffective for women > or =40 years. PMID:10864366

  9. Beyond chronological age. Examining perceived future time and subjective health as age-related mediators in relation to work-related motivations and well-being

    NARCIS (Netherlands)

    Kooij, Dorien; Lange, Annet de; Jansen, Paul; Dikkers, Josje

    2013-01-01

    Since workforces across the world are aging, researchers and organizations need more insight into how and why occupational well-being, together with work-related attitudes and motivations, change with age. Lifespan theories point to subjective health and future time perspective (i.e. an individual's

  10. Premature ovarian failure

    Directory of Open Access Journals (Sweden)

    Persani Luca

    2006-04-01

    Full Text Available Abstract Premature ovarian failure (POF is a primary ovarian defect characterized by absent menarche (primary amenorrhea or premature depletion of ovarian follicles before the age of 40 years (secondary amenorrhea. It is a heterogeneous disorder affecting approximately 1% of women e.g. Turner syndrome represent the major cause of primary amenorrhea associated with ovarian dysgenesis. Despite the description of several candidate genes, the cause of POF remains undetermined in the vast majority of the cases. Management includes substitution of the hormone defect by estrogen/progestin preparations. The only solution presently available for the fertility defect in women with absent follicular reserve is ovum donation.

  11. Accelerated ovarian aging in mice by treatment of busulfan and cyclophosphamide

    Institute of Scientific and Technical Information of China (English)

    Yan JIANG; Jing ZHAO; Hui-jing QI; Xiao-lin LI; Shi-rong ZHANG; Daniel W.SONG; Chi-yang YU

    2013-01-01

    Busulfan/cyclophosphamide (Bu/Cy) conditioning regimen has been widely used to treat cancer patients,while their effects on major internal organs in females are not fully understood.We treated female mice with Bu/Cy,and examined the histopathology of major internal organs on Day 30 after the treatment.The results show that Bu/Cy treatment affected the ovaries most extensively,while it had less effect on the spleen,lungs,and kidneys,and no effect on the heart,liver,stomach,and pancreas.To better understand the effect of Bu/Cy on the ovaries,we counted follicles,and determined the levels of ovarian steroids.The Bu/Cy-treated mice showed a reduction of primordial and primary follicles (P<0.01) on Day 30 and a marked loss of follicles at all developmental stages (P<0.01) on Day 60.Plasma levels of estradiol and progesterone in Bu/Cy-treated mice decreased by 43.9% and 61.4%,respectively.Thus,there was a gradual process of follicle loss and low estradiol in Bu/Cy-treated mice; this is a profile similar to what is found in women with premature ovarian failure (POF).The Bu/Cy-treated mice may serve as a useful animal model to study the dynamics of follicle loss in women undergoing POF.

  12. An Integrated Quantitative Methodology to Longitudinally Characterize Complex Dynamic Processes Associated with Ovarian Aging and the Menopausal Transition

    Directory of Open Access Journals (Sweden)

    Huiyong Zheng

    2011-06-01

    Full Text Available An integrative methodology is developed to characterize the complex patterns of change in highly variable dynamic biological processes. The method permits estimatation of the population mean profile, multiple change points and length of time-windows defined by any two change points of interest using a semi-/non-parametric stochastic mixed effect model and a Bayesian Modeling Average (BMA approach to account for model uncertainty. It also allows estimation of the mean rate of change of sub-processes by fitting piecewise linear mixed effect models. The methodology is applied to characterize the stages of female ovarian aging and the menopausal transition defined by hormone measures of estradiol (E2 and follicle stimulating hormone (FSH from two large-scale epidemiological studies with community-based longitudinal designs and ethnic diversity.

  13. The WAIS Divide deep ice core WD2014 chronology – Part 1: Methane synchronization (68–31 ka BP) and the gas age–ice age difference

    OpenAIRE

    Buizert, C.; Cuffey, K.M.; J. P. Severinghaus; Baggenstos, D.; T. J. Fudge; E. J. Steig; Markle, B. R.; M. Winstrup; R. H. Rhodes; E. J. Brook; Sowers, T. A.; G. D. Clow; Cheng, H.; Edwards, R. L.; Sigl, M.

    2015-01-01

    The West Antarctic Ice Sheet Divide (WAIS Divide, WD) ice core is a newly drilled, high-accumulation deep ice core that provides Antarctic climate records of the past ∼68 ka at unprecedented temporal resolution. The upper 2850 m (back to 31.2 ka BP) have been dated using annual-layer counting. Here we present a chronology for the deep part of the core (67.8–31.2 ka BP), which is based on stratigraphic matching to annual-layer-counted Greenland ice cores using globally we...

  14. Ovarian Cancer Statistics

    Science.gov (United States)

    ... population data for older age groups are available. Statistics at a Glance Show More At a Glance ... with ovarian cancer in the United States. Survival Statistics Show More How Many People Survive 5 Years ...

  15. Early Alterations in Ovarian Surface Epithelial Cells and Induction of Ovarian Epithelial Tumors Triggered by Loss of FSH Receptor

    Directory of Open Access Journals (Sweden)

    Xinlei Chen

    2007-06-01

    Full Text Available Little is known about the behavior of the ovarian surface epithelium (OSE, which plays a central role in ovarian cancer etiology. It has been suggested that incessant ovulation causes OSE changes leading to transformation and that high gonadotropin levels during postmenopause activate OSE receptors, inducing proliferation. We examined the chronology of OSE changes, including tumor appearance, in a mouse model where ovulation never occurs due to deletion of follitropin receptor. Changes in epithelial cells were marked by pan-cytokeratin (CK staining. Histologic changes and CK staining in the OSE increased from postnatal day 2. CK staining was observed inside the ovary by 24 days and increased thereafter in tumor-bearing animals. Ovaries from a third of aged (1 year mutant mice showed CK deep inside, indicating cell migration. These tumors resembled serous papillary adenoma of human ovaries. Weak expression of GATA-4 and elevation of PCNA, cyclooxygenase-1, cyclooxygenase-2, and plateletderived growth factor receptors α and β in mutants indicated differences in cell proliferation, differentiation, and inflammation. Thus, we report that OSE changes occur long before epithelial tumors appear in FORKO mice. Our results suggest that neither incessant ovulation nor follicle-stimulating hormone receptor presence in the OSE is required for inducing ovarian tumors; thus, other mechanisms must contribute to ovarian tumorigenesis.

  16. Chronology. Classroom Focus.

    Science.gov (United States)

    McGoldrick, Neale

    1995-01-01

    Presents a chronology of important dates and events in the struggle for women's rights and women's suffrage. Begins in 1648 with the first call for women's suffrage in Maryland and concludes in 1920 with the passage of the 19th Amendment by Tennessee. (CFR)

  17. Premature ovarian failure and ovarian autoimmunity

    NARCIS (Netherlands)

    J.A. Schoemaker (Joop); H.A. Drexhage (Hemmo); A. Hoek (Annemieke)

    1997-01-01

    textabstractPremature ovarian failure (POF) is defined as a syndrome characterized by menopause before the age of 40 yr. The patients suffer from anovulation and hypoestrogenism. Approximately 1% of women will experience menopause before the age of 40 yr. POF is a heter

  18. CA-125 and risk of malignancy index for screening for malignancy in fertile aged females with ovarian cyst, which is more cost effectiveness?

    Directory of Open Access Journals (Sweden)

    Viroj Wiwanitkit

    2013-01-01

    Full Text Available Background: Ovarian tumor is a cause of infertility in the fertile-aged women. Also, it can also turns into malignancy and causes deadly outcome. Screening for malignancy is an important management. Aims: The available screening methods that are widely used at present include CA-125 determination and the risk of malignancy index (RMX, which is a combined CA-125 with ultrasonography, determination. Materials and Methods: Here, the author tries to assess cost-effectiveness of both alternative in screening by basic medical economics technique. Statistics: Classical descriptive analysis was used for cost effectiveness calculation. Results: In this work, from the cost-effectiveness analysis, the CA-125 test is more cost-effectiveness than RMX. Conclusion: This reflects that the usage of additional ultrasonography test for increasing the diagnostic activity in screening for ovarian cyst in the fertile aged females in Thailand is still not appropriate.

  19. Biomarkers of Ovarian Reserve

    Directory of Open Access Journals (Sweden)

    William E. Roudebush

    2008-01-01

    Full Text Available The primary function of the female ovary is the production of a mature and viable oocyte capable of fertilization and subsequent embryo development and implantation. At birth, the ovary contains a finite number of oocytes available for folliculogenesis. This finite number of available oocytes is termed “the ovarian reserve”. The determination of ovarian reserve is important in the assessment and treatment of infertility. As the ovary ages, the ovarian reserve will decline. Infertility affects approximately 15-20% of reproductive aged couples. The most commonly used biomarker assay to assess ovarian reserve is the measurement of follicle stimulating hormone (FSH on day 3 of the menstrual cycle. However, antimüllerian hormone and inhibin-B are other biomarkers of ovarian reserve that are gaining in popularity since they provide direct determination of ovarian status, whereas day 3 FSH is an indirect measurement. This review examines the physical tools and the hormone biomarkers used to evaluate ovarian reserve.

  20. Real Wage Chronology

    OpenAIRE

    Amy Peng; Louis N. Christofides

    2009-01-01

    We process information in a large number of Canadian wage contracts, signed over a period of several decades, to generate the long-run history of the real wage for each bargaining pair. We term these hitherto unexamined histories ‘chronologies’. We are able to generate 1574 continuous real wage chronologies and we examine the evolution of the real wage in each case. We explore the influence of productivity growth, the labour relations record of the pair, the influence of industry and region a...

  1. Detailed chronology of mid-altitude fluvial system response to changing climate and societies at the end of the Little Ice Age (Southwestern Alps and Cévennes, France)

    Science.gov (United States)

    Astrade, Laurent; Jacob-Rousseau, Nicolas; Bravard, Jean-Paul; Allignol, Françoise; Simac, L.

    2011-10-01

    Over a historical timescale, landscapes have been strongly affected by fluctuations in climate and by the impact of human societies. This study examines the historical evolution of mid-altitude fluvial systems in the Western Alps and Cévennes (SE Massif Central) in the context of marked climate and anthropogenic change at the end of the Little Ice Age (late 19th century). This work contributes to the reconstruction of river paleodynamics by investigating the nature and chronology of geomorphological changes in upper river basins. In order to produce a detailed reconstruction of hydromorphological changes, we combined two approaches: the study of historical archives and the use of bioindicators (the dating of terraces using dendrochronology and of silt benches using lichenometry in order to reconstruct the evolution of the river channels). The 19th century is a particularly propitious period for the study of surface dynamics because archives have preserved a wealth of qualitative and quantitative data concerning rivers (economic statistics, meteorological and hydrological observations, illustrative documents, descriptions by contemporary observers). It is also a period for which reliable dating methods are available for detrital deposits in rivers. The period provides new information on how the transition between the Little Ice Age and current climate conditions affected the evolution of drainage basins and stream channels by highlighting a succession of phases in the erosive process (e.g., the preparatory role of the drought of 1830-1838 in the erosion crisis of 1855-1870) and refining the chronology of events (very early onset of riverbed incision). The results highlight the effect of climate (small hydroclimatic fluctuations), amplified by strong anthropization, on the rhythm of landscape change and on the relative stabilization of the landscape at the end of the 19th century. In addition, the synchronization of phenomena on the two sides of the Rhone Valley

  2. Ovarian reserve parameters

    DEFF Research Database (Denmark)

    Bentzen, J G; Forman, Julie Lyng; Pinborg, Anja;

    2012-01-01

    It remains controversial whether anti-Müllerian hormone (AMH) concentration is influenced by hormonal contraception. This study quantified the effect of hormonal contraception on both endocrine and sonographic ovarian reserve markers in 228 users and 504 non-users of hormonal contraception. On day...... concentration and AFC may not retain their accuracy as predictors of ovarian reserve in women using hormonal contraception. Serum anti-Müllerian hormone (AMH) concentration is an indirect marker of the number of small follicles in the ovary and thereby the ovarian reserve. The AMH concentration is now widely...... 2-5 of the menstrual cycle or during withdrawal bleeding, blood sampling and transvaginal sonography was performed. After adjusting for age, ovarian reserve parameters were lower among users than among non-users of hormonal contraception: serum AMH concentration by 29.8% (95% CI 19.9 to 38...

  3. Management of ovarian cysts

    DEFF Research Database (Denmark)

    Knudsen, Ulla Breth; Tabor, Ann; Mosgaard, Berit Jul;

    2004-01-01

    BACKGROUND: The treatment of an ovarian cyst relies on its nature, and accurate preoperative discrimination of benign and malignant cysts is therefore of crucial importance. This study was undertaken to review the literature concerning the preoperative diagnosis and treatment of ovarian cysts....... METHODS: Articles concerning ovarian cysts from a medline literature search during the period 1985-2003 were included in addition to articles found as references in the initial publications. RESULTS: Different methods for discriminating between benign and malignant ovarian cysts are discussed....... The diagnosis and the treatment are assessed in relation to age, menopausal status, pregnancy, and whether the cyst is presumed to be benign or malignant. In general, expectant management is the choice in premenopausal and pregnant women with non-suspicious cysts and normal levels of CA-125. In postmenopausal...

  4. Northernmost paleo-tethyan oceanic basin in Tibet: Geo- chronological evidence from 40Ar/39Ar age dating of Dur'ngoi ophiolite

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Whole rock 40Ar/39Ar age dating has been conducted on a basalt sample from Dur'ngoi ophiolite, Qinghai Province, which was reported to be the northernmost paleo-tethyan oceanic basin in Tibet. A high temperature plateau age (345.3±7.9 Ma) with an isochorn age (336.6±7.1 Ma) has been obtained, representing the eruption time of oceanic crust. Considering related geological settings, the new age provides constraints on the northernmost paleo-tethyan suture zone in Tibet and the tectonic evolution of Paleo-tethys in Northeast Tibet and adjacent areas.

  5. The comparison between measurement of open apices of third molars and Demirjian stages to test chronological age of over 18 year olds in living subjects.

    Science.gov (United States)

    Cameriere, R; Ferrante, L; De Angelis, D; Scarpino, F; Galli, F

    2008-11-01

    This paper concerns a method for assessing adult age based on the relationship between age and the third molar maturity index (I(3M)), which is related to the measurement of the open apices of the third molar. Furthermore, this method was compared to those based on Demirjian's stages G and H. The sample consisted of 906 Caucasian individuals aged between 14 and 23 years (53.6% females and 46.4% males). Orthopantomographs were analyzed by two observers and calibrated by means of the concordance correlation coefficient for the reproducibility of the third molar maturity index (I(3M)) and kappa statistics for reproducibility of the Demirjian stages. Probabilities for an individual to be older than 18 years of age (adult age) were derived using the measurements of the third molar maturity index (I(3M)). These results were exploited to set out a threshold value to assign an individual to juvenile or adult age. A cutoff value of I(3M) = 0.08 was taken. The sensitivity of this test was 70% and specificity was 98%. Furthermore, the proportion of individuals with a correct classification was 83%. The results of the test showed a better specificity when compared to the choice of stage G and a better sensitivity when compared to the choice of stage H for adult age.

  6. Ascertaining year of birth/age at death in forensic cases: A review of conventional methods and methods allowing for absolute chronology

    DEFF Research Database (Denmark)

    Lynnerup, Niels; Kjeldsen, H; Zweihoff, R;

    2010-01-01

    Based on an actual case, where we were able to ascertain the year of birth of three dead babies found in a deep-freezer to within 1–2 years (1986, 1988 and 2004, respectively), we review the current state of forensic age determination/year of birth determination. The age of an individual (year of......-pulse, when these proteins were formed (at birth). The bomb pulse reflects a dramatic change in atmospheric 14C content due to nuclear bomb testing, and these dramatic changes can be rather tightly related to single calendar years....... of age at death, e.g. protein racemisation, or, as in our case, radiocarbon methods. Especially the latter method may in fact yield absolute ages (years of birth), because 14C activity, as measured in specific proteins in specific cells or tissues in the body, were in equilibrium with the so-called bomb...

  7. Prospects for Chronological Studies of Martian Rocks and Soils

    Science.gov (United States)

    Nyquist, L. E.; Shih, C-Y.; Reese, Y. D.

    2008-01-01

    Chronological information about Martian processes comes from two sources: Crater-frequency studies and laboratory studies of Martian meteorites. Each has limitations that could be overcome by studies of returned Martian rocks and soils. Chronology of Martian volcanism: The currently accepted chronology of Martian volcanic surfaces relies on crater counts for different Martian stratigraphic units [1]. However, there is a large inherent uncertainty for intermediate ages near 2 Ga ago. The effect of differing preferences for Martian cratering chronologies [1] is shown in Fig. 1. Stoeffler and Ryder [2] summarized lunar chronology, upon which Martian cratering chronology is based. Fig. 2 shows a curve fit to their data, and compares to it a corresponding lunar curve from [3]. The radiometric ages of some lunar and Martian meteorites as well as the crater-count delimiters for Martian epochs [4] also are shown for comparison to the craterfrequency curves. Scaling the Stoeffler-Ryder curve by a Mars/Moon factor of 1.55 [5] places Martian shergottite ages into the Early Amazonian to late Hesperian epochs, whereas using the lunar curve of [3] and a Mars/Moon factor 1 consigns the shergottites to the Middle-to-Late Amazonian, a less probable result. The problem is worsened if a continually decreasing cratering rate since 3 Ga ago is accepted [6]. We prefer the adjusted St ffler-Ryder curve because it gives better agreement with the meteorite ages (Fig.

  8. The use of AMS radiocarbon dating for Xia-Shang-Zhou chronology

    CERN Document Server

    Guo, Z Y; LiuKeXin; Lu Xiang Yang; Ma Hong Ji; Wu Xiao Hon; Yuan Si Xun

    2000-01-01

    The possibility and problems of using radiocarbon dating to historical chronology are discussed. The current situation of ancient Chinese chronology and the project of Xia-Shang-Zhou chronology are introduced. A chronological study requires the AMS radiocarbon dating with high precision, high reliability and high efficiency. The Peking University AMS facility (PKUAMS) has been upgraded and a series of quality control steps were adopted. To reduce the error of calendar age, wiggle matching with serial samples should be used. Some preliminary results of Xia-Shang-Zhou chronology are presented.

  9. A Case Study Assessing the Auditory and Speech Development of Four Children Implanted with Cochlear Implants by the Chronological Age of 12 Months

    Directory of Open Access Journals (Sweden)

    Birgit May-Mederake

    2013-01-01

    Full Text Available Children with severe hearing loss most likely receive the greatest benefit from a cochlear implant (CI when implanted at less than 2 years of age. Children with a hearing loss may also benefit greater from binaural sensory stimulation. Four children who received their first CI under 12 months of age were included in this study. Effects on auditory development were determined using the German LittlEARS Auditory Questionnaire, closed- and open-set monosyllabic word tests, aided free-field, the Mainzer and Göttinger speech discrimination tests, Monosyllabic-Trochee-Polysyllabic (MTP, and Listening Progress Profile (LiP. Speech production and grammar development were evaluated using a German language speech development test (SETK, reception of grammar test (TROG-D and active vocabulary test (AWST-R. The data showed that children implanted under 12 months of age reached open-set monosyllabic word discrimination at an age of 24 months. LiP results improved over time, and children recognized 100% of words in the MTP test after 12 months. All children performed as well as or better than their hearing peers in speech production and grammar development. SETK showed that the speech development of these children was in general age appropriate. The data suggests that early hearing loss intervention benefits speech and language development and supports the trend towards early cochlear implantation. Furthermore, the data emphasizes the potential benefits associated with bilateral implantation.

  10. Accessory mineral U-Th-Pb ages and 40Ar/39Ar eruption chronology, and their bearing on rhyolitic magma evolution in the Pleistocene Coso volcanic field, California

    Science.gov (United States)

    Simon, J.I.; Vazquez, J.A.; Renne, P.R.; Schmitt, A.K.; Bacon, C.R.; Reid, M.R.

    2009-01-01

    We determined Ar/Ar eruption ages of eight extrusions from the Pleistocene Coso volcanic field, a long-lived series of small volume rhyolitic domes in eastern California. Combined with ion-microprobe dating of crystal ages of zircon and allanite from these lavas and from granophyre geothermal well cuttings, we were able to track the range of magma-production rates over the past 650 ka at Coso. In ??? 230 ka rhyolites we find no evidence of protracted magma residence or recycled zircon (or allanite) from Pleistocene predecessors. A significant subset of zircon in the ???85 ka rhyolites yielded ages between ???100 and 200 Ma, requiring that generation of at least some rhyolites involves material from Mesozoic basement. Similar zircon xenocrysts are found in an ???200 ka granophyre. The new age constraints imply that magma evolution at Coso can occur rapidly as demonstrated by significant changes in rhyolite composition over short time intervals (???10's to 100's ka). In conjunction with radioisotopic age constraints from other young silicic volcanic fields, dating of Coso rhyolites highlights the fact that at least some (and often the more voluminous) rhyolites are produced relatively rapidly, but that many small-volume rhyolites likely represent separation from long-lived mushy magma bodies. ?? The Author(s) 2009.

  11. BILATERAL IMMATURE OVARIAN TERATOMA

    Directory of Open Access Journals (Sweden)

    Vinay

    2014-10-01

    Full Text Available : Immature teratoma (IMT is tumor composed of tissues from ectoderm, mesoderm and endoderm and is considered the second most common germ cell tumor. IMT account for 10-20% of all ovarian neoplasias in women less than 20 years of age, with peak incidence between 15 and 19 years old. IMT rarely occurs during menopause. We herein reporting a rare case in a 3 years old girl with bilateral immature ovarian teratoma which is very rare in bilateralism of tumor as well as the fact that the patient age is below the average for the occurrence of these tumors.

  12. Menoprogen, a TCM Herbal Formula for Menopause, Increases Endogenous E2 in an Aged Rat Model of Menopause by Reducing Ovarian Granulosa Cell Apoptosis

    Science.gov (United States)

    Li, Yu; Ma, Hong; Lu, Ye; Tan, B. J.; Xu, L.; Lawal, Temitope O.; Mahady, Gail B.; Liu, Daniel

    2016-01-01

    The effect of Menoprogen (MPG) on ovarian granulosa cell (GC) apoptosis was investigated in vitro and in vivo in an aged rat model of menopause. Intragastric administration of Menoprogen or estradiol valerate to 14-month-old senile female rats for eight weeks increased plasma E2 levels, as well as the weight of both ovarian and uterine tissues. Flow cytometric (FCM) analysis of isolated GCs from MPG-treated aged rats showed reductions in the G0/G1 ratio and apoptotic peaks. Isolated GCs also exhibited an increase in cell size and the number of cytoplastic organelles and intracellular gap junctions, the reappearance of secretory granules, and a lack of apoptotic bodies as determined by TEM. Results from a TdT-mediated dUTP nick end-labeling (TUNEL) assay revealed a reduction in TUNEL-positive GCs after MPG treatment. Immunohistochemical analysis showed a downregulation of proapoptotic Bax proteins and an upregulation of antiapoptotic Bcl-2 proteins. The addition of MPG-medicated serum to the media of cultured GCs also reduced cadmium chloride-induced apoptosis and downregulated caspase-3 protein expression. This work demonstrates that Menoprogen inhibits GC apoptosis in aged female rats and thereby increases E2 production. This represents a novel mechanism of action for this herbal medicine in the treatment of menopausal symptoms. PMID:26981526

  13. Menoprogen, a TCM Herbal Formula for Menopause, Increases Endogenous E2 in an Aged Rat Model of Menopause by Reducing Ovarian Granulosa Cell Apoptosis

    Directory of Open Access Journals (Sweden)

    Yu Li

    2016-01-01

    Full Text Available The effect of Menoprogen (MPG on ovarian granulosa cell (GC apoptosis was investigated in vitro and in vivo in an aged rat model of menopause. Intragastric administration of Menoprogen or estradiol valerate to 14-month-old senile female rats for eight weeks increased plasma E2 levels, as well as the weight of both ovarian and uterine tissues. Flow cytometric (FCM analysis of isolated GCs from MPG-treated aged rats showed reductions in the G0/G1 ratio and apoptotic peaks. Isolated GCs also exhibited an increase in cell size and the number of cytoplastic organelles and intracellular gap junctions, the reappearance of secretory granules, and a lack of apoptotic bodies as determined by TEM. Results from a TdT-mediated dUTP nick end-labeling (TUNEL assay revealed a reduction in TUNEL-positive GCs after MPG treatment. Immunohistochemical analysis showed a downregulation of proapoptotic Bax proteins and an upregulation of antiapoptotic Bcl-2 proteins. The addition of MPG-medicated serum to the media of cultured GCs also reduced cadmium chloride-induced apoptosis and downregulated caspase-3 protein expression. This work demonstrates that Menoprogen inhibits GC apoptosis in aged female rats and thereby increases E2 production. This represents a novel mechanism of action for this herbal medicine in the treatment of menopausal symptoms.

  14. Chronology of the shell bar section and a discussion on the ages of the Late Pleistocene lacustrine deposits in the paleolake Qarhan,Qaidam basin

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Shell bar,composed of abundant fossil shells of Corbicula fluminea müller and Corbicula largillierti philippi and located at the southeastern end (36°30'N,96°12'E) of the paleolake Qarhan,is one of the most prominent features in the Qaidam basin.It is the highest site where such species of fossil shells have been found in the Late Pleistocene age.A 2.6-m-thick fresh profile was manually excavated to determine the formation ages and the scope of the high paleolake levels.Accelerator mass spectrometry (AMS),conventional radiocarbon dating,and sector inductively coupled plasma-mass spectroscopy 230Th methods were used to investigate the reliability and accuracy of dating results in different laboratories.Ages of various components (e.g.acid residual and acid soluble fraction of the organic matter) from the same sample were determined.Age differences of a variety of materials (e.g.organic matter,fossil shells,and salt crystals),and age differences at the same sampling position were evaluated.Dating shows that the AMS ages given by alkali residue and acid soluble fractions vary greatly,e.g.,from 124.5 cm upwards.The dates given by the acid soluble fraction were normal.Down the column,the dates show a reverse pattern and those of alkali residues,especially the lower part of the section,show an unstable pattern.These imply that organic matter had been influenced by two separate processes.One possible explanation is that the alkali residual fraction most likely had been contaminated by dead carbon-bearing reworked material because the study section is located near the edge of the paleolake and could have been easily influenced by old eroded deposits.Another is that the acid soluble fraction could have been contaminated by upward-flowing groundwater containing soluble organic matter.The amount of this soluble organic material should be very small because the strongest age reversal is in the lower part,where the TOC content remains low,meaning that the change of soluble

  15. Chronological objects in demographic research

    Directory of Open Access Journals (Sweden)

    Frans J. Willekens

    2013-03-01

    Full Text Available BACKGROUND Calendar time, age and duration are chronological objects. They represent an instant or a time period. Age and duration are usually expressed in units with varying lengths. The number of days in a month or a year depends on the position on the calendar. The units are also not homogeneous and the structure influences measurement. One solution, common in demography, is to use units that are large enough for the results not to be seriously affected by differences in length and structure. Another approach is to take the idiosyncrasy of calendars into account and to work directly with calendar dates. The technology that enables logical and arithmetic operations on dates is available. OBJECTIVE To illustrate logical and arithmetic operations on dates and conversions between time measurements. METHODS Software packages include utilities to process dates. I use existing and a few new utilities in R to illustrate operations on dates and conversions between calendar dates and elapsed time since a reference moment or a reference event. Three demographic applications are presented. The first is the impact of preferences for dates and days on demographic indicators. The second is event history analysis with time-varying covariates. The third is microsimulation of life histories in continuous time. CONCLUSIONS The technology exists to perform operations directly on dates, enabling more precise calculations of duration and elapsed time in demographic analysis. It eliminates the need for (a approximations and (b transformations of dates, such as Century Month Code, that are convenient for computing durations but are a barrier to interpretation. Operations on dates, such as the computation of age, should consider time units of varying length.

  16. Premature ovarian failure : from phenotype to genotype

    NARCIS (Netherlands)

    Knauff, A.H.

    2009-01-01

    Postponement of childbearing has led to increased rates of age-related female subfertility. Age-related decreases in ovarian follicle numbers and decay in oocyte quality influence the natural loss of fecundity and ultimately the start of menopause. The rate of ovarian ageing is highly variable among

  17. Gender and chronological age affect erythrocyte membrane oxidative indices in citrate phosphate dextrose adenine-formula 1 (CPDA-1) blood bank storage condition.

    Science.gov (United States)

    Erman, Hayriye; Aksu, Uğur; Belce, Ahmet; Atukeren, Pınar; Uzun, Duygu; Cebe, Tamer; Kansu, Ahmet D; Gelişgen, Remisa; Uslu, Ezel; Aydın, Seval; Çakatay, Ufuk

    2016-07-01

    It is well known that in vitro storage lesions lead to membrane dysfunction and decreased number of functional erythrocytes. As erythrocytes get older, in storage media as well as in peripheral circulation, they undergo a variety of biochemical changes. In our study, the erythrocytes with different age groups in citrate phosphate dextrose adenine-formula 1 (CPDA-1) storage solution were used in order to investigate the possible effect of gender factor on oxidative damage. Oxidative damage biomarkers in erythrocyte membranes such as ferric reducing antioxidant power, pro-oxidant-antioxidant balance, protein-bound advance glycation end products, and sialic acid were analyzed. Current study reveals that change in membrane redox status during blood-bank storage condition also depends on both gender depended homeostatic factors and the presence of CPDA-1. During the storage period in CPDA-1, erythrocytes from the male donors are mostly affected by free radical-mediated oxidative stress but erythrocytes obtained from females are severely affected by glyoxidative stress.

  18. BILATERAL IMMATURE OVARIAN TERATOMA

    OpenAIRE

    Vinay; Aditya Pratap; Chetan; Ramesh; Rajlaxmi Jaysing

    2014-01-01

    : Immature teratoma (IMT) is tumor composed of tissues from ectoderm, mesoderm and endoderm and is considered the second most common germ cell tumor. IMT account for 10-20% of all ovarian neoplasias in women less than 20 years of age, with peak incidence between 15 and 19 years old. IMT rarely occurs during menopause. We herein reporting a rare case in a 3 years old girl with bilateral immature ovarian teratoma which is very rare in bilateralism of tumor as well as the fac...

  19. A novel diagnostic index combining HE4, CA125 and age may improve triage of women with suspected ovarian cancer - An international multicenter study in women with an ovarian mass

    DEFF Research Database (Denmark)

    Karlsen, Mona Aarenstrup; Høgdall, Estrid V S; Christensen, Ib J;

    2015-01-01

    masses and 550 patients with ovarian cancer. RESULTS: Overall, 2665 patients were included. CPH-I was highly significant in discriminating benign from malignant ovarian disease. At the defined cut-off of 0.070 for CPH-I the sensitivity and specificity were 95.0% and 78.4% respectively in the training...

  20. "Incessant ovulation" and ovarian cancer.

    Science.gov (United States)

    Casagrande, J T; Louie, E W; Pike, M C; Roy, S; Ross, R K; Henderson, B E

    1979-07-28

    A case-control study of 150 ovarian cancer patients under the age of 50 and individually matched controls was done to study the influence of fertility and oral contraceptive use on the risk of ovarian cancer. The risk decreased with increasing numbers of live births, with increasing numbers of incomplete pregnancies, and with the use of oral contraceptives. These three factors can be amalgamated into a single index of protection--"protected time"--by considering them all as periods of anovulation. The complement of protected time--viz., "ovulatory age", the period between menarche and diagnosis of ovarian cancer (or cessation of menses) minus "protected time"--was strongly related to risk of ovarian cancer. Other factors found to be associated with increased ovarian cancer risk were obesity, cervical polyps, and gallbladder disease. Women who had an "immediate" intolerance to oral contraceptive use had a fourfold increased risk of ovarian cancer. 7 patients, but no controls, could recall a family history of ovarian cancer. PMID:89281

  1. Chronology of enstatite chondrites and ureilites

    International Nuclear Information System (INIS)

    This paper summarizes the chronological studies on enstatite chondrites and ureilites, both of which are special groups of meteorites with unknown origins. Two unequilibrated enstatite chondrites, Qingzhen and Yamato 6901 (E3), showed the highly disturbed Rb-Sr system, while their silicate fractions yielded the 2.1 Ga isochron. The thermally metamorphosed enstatite chondrite Khairpur (E6) showed the older Rb-Sr age of 4.50 Ga. The parent body of E3 chondrites experienced late thermal event at low temperature, which broke down alkali-bearing sulfides in E3. The observed Rb-Sr data are consistent with the mobilization of Rb from alkali-sulfide to silicate phases. Ureilites show highly depleted trace elements abundance which makes it difficult to determine the age of the formation. The U-Pb and Sm-Nd age determination of low-Ca ureilite Goalpara showed that the Pb and Nd isotopes are heavily contaminated with terrestrial components. The acid residues of high-Ca ureilite MET-78008 were free of contamination and defined the old U-Pb age of 4.563±0.006 Ga. The early formation of ureilites supports their formation through the collisional destruction of the parent body. Including the ureilite date, many evolved meteorites formed within the first 10 million years of the solar system history. Future studies on meteorite chronology with the purpose of understanding the early history of the solar system should focus on the fine time resolution through the precise U-Pb age determination or the relative age determination using the extinct nuclides with half lives less than 10 million years. (author)

  2. The boundary of the chronology violating set

    CERN Document Server

    Minguzzi, E

    2016-01-01

    A sufficiently general definition for the future and past boundaries of the chronology violating region is given. In comparison to previous studies, this work does not assume that the complement of the chronology violating set is globally hyperbolic. The boundary of the chronology violating set is studied and several propositions are obtained which confirm the reasonability of the definition. Some singularity theorems related to chronology violation are considered.

  3. Poor ovarian reserve

    Directory of Open Access Journals (Sweden)

    Padma Rekha Jirge

    2016-01-01

    Full Text Available Poor ovarian reserve (POR is an important limiting factor for the success of any treatment modality for infertility. It indicates a reduction in quantity and quality of oocytes in women of reproductive age group. It may be age related as seen in advanced years of reproductive life or may occur in young women due to diverse etiological factors. Evaluating ovarian reserve and individualizing the therapeutic strategies are very important for optimizing the success rate. Majority or women with POR need to undergo in vitro fertilization to achieve pregnancy. However, pregnancy rate remains low despite a plethora of interventions and is associated with high pregnancy loss. Early detection and active management are essential to minimize the need for egg donation in these women.

  4. Penetrance of breast cancer, ovarian cancer and contralateral breast cancer in BRCA1 and BRCA2 families : high cancer incidence at older age

    NARCIS (Netherlands)

    van der Kolk, Dorina M.; de Bock, Geertruida H.; Leegte, Beike K.; Schaapveld, Michael; Mourits, Marian J. E.; de Vries, J; van der Hout, Annemieke H.; Oosterwijk, Jan C.

    2010-01-01

    Accurate estimations of lifetime risks of breast and ovarian cancer are crucial for counselling women from BRCA1/2 families. We therefore determined breast and ovarian cancer penetrance in BRCA1/2 mutation families in the northern Netherlands and compared them with the incidence of cancers in the ge

  5. Preservation of ovarian function by ovarian transposition performed before pelvic irradiation during childhood.

    Science.gov (United States)

    Thibaud, E; Ramirez, M; Brauner, R; Flamant, F; Zucker, J M; Fékété, C; Rappaport, R

    1992-12-01

    Ovarian transposition in adults has been shown to protect ovarian function in about 60% of cases by reducing ovarian exposure to less than 4 to 7 Gy. We therefore evaluated the effect of ovarian transposition during childhood or adolescence. Eighteen girls had ovarian transposition performed at a mean (+/- SEM) age of 9.4 +/- 1.2 years (range, 1.2 to 16 years). Twelve were prepubertal and six had menstruated at the time of ovarian transposition. The initial abnormalities were Hodgkin disease (5 cases), iliac Ewing sarcoma (3), medulloblastoma (2), ovarian seminoma (1), and vaginal or uterine tumor (7). The irradiation was external in 11 cases and local by vaginal curietherapy in 7 cases. Fifteen girls received chemotherapy. The ovarian transposition was bilateral in 15 patients and unilateral in 3 cases; in the latter the other ovary had been destroyed by the tumor or by abdominal irradiation. Ovaries were placed just below the iliac crest (15 cases) or posterolateral to the uterus (3); thus, the calculated ovarian radiation dose was up to 9.5 Gy. At the time of evaluation (8.6 +/- 0.9 years after ovarian transposition), 16 girls had menstruated and 2 remained amenorrheic because of major lesions of the vagina and uterus caused by the vaginal curietherapy. Basal plasma gonadotropin values were normal. Ovulation was documented in seven cases. Two pregnancies occurred. Complications of ovarian transposition were present in four patients: intestinal occlusion, dyspareunia, functional ovarian cysts, and pelvic adhesions with tubal obstruction. We conclude that ovarian transposition, performed before abdominopelvic irradiation during childhood, can preserve ovarian function. Longer follow-up is required to assess the risk of ovarian dystrophy because of vascular lesions or chemotherapy. PMID:1447649

  6. CHRONOLOGICAL INVENTORY OF CHEMISTRY TEACHING

    OpenAIRE

    Laxman S. Bhattar; SWAMINATH L.BHATTAR

    2013-01-01

    The Chronological Research of Chemistry teaching in the science education isinvented by the following pioneer philosophers and they developed the skills abilitieswhich is remarked by the Greek philosophers are socrates and plato (in 116 to 127 BC)given an idea an naturalistic and conceptual thoughts and highlights on water. Chinaphilosophers (365 to 427 BC) Taoism made pioneer of Alchemy used in medicines andtranslation preparation of Au (Gold). Epicurea (341 to 371 to 400 BC) developed kinet...

  7. Statin use and risk for ovarian cancer

    DEFF Research Database (Denmark)

    Baandrup, L; Dehlendorff, C; Friis, Søren;

    2015-01-01

    BACKGROUND: Limited data suggest that statin use reduces the risk for ovarian cancer. METHODS: Using Danish nationwide registries, we identified 4103 cases of epithelial ovarian cancer during 2000-2011 and age-matched them to 58,706 risk-set sampled controls. Conditional logistic regression was...... used to estimate adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for epithelial ovarian cancer overall, and for histological types, associated with statin use. RESULTS: We observed a neutral association between ever use of statins and epithelial ovarian cancer risk (OR=0.98, 95% CI=0.......87-1.10), and no apparent risk variation according to duration, intensity or type of statin use. Decreased ORs associated with statin use were seen for mucinous ovarian cancer (ever statin use: OR=0.63, 95% CI=0.39-1.00). CONCLUSIONS: Statin use was not associated with overall risk for epithelial ovarian cancer...

  8. The Chronology of Third Molar Eruption in the Croatian Population

    OpenAIRE

    Brkić, Hrvoje; Vodanović, Marin; Dumančić, Jelena; Lovrić, Željka; Čuković-Bagić, Ivana; Petrovečki, Mladen

    2011-01-01

    Dental age estimation is common in orthodontics, paedodontics, paleodontology and forensic dentistry. The aim of this study was to assess chronological course of eruptive developmental phases of third molar and to establish parameters for the Croatian population. Sample of this study consisted of 1249 orthopantomograms of 530 (42.4%) male and 719 (57.6%) female subjects, aged 10 to 25 years. Eruptive phases were classified in 4 stages. No significant sex difference was found. Esta...

  9. A retrospective analytic study of clino-histopathological correlation of ovarian mass

    Directory of Open Access Journals (Sweden)

    Avani Patel

    2016-11-01

    Conclusions: In our study, non-neoplastic ovarian masses presented in equal proportions as that of neoplastic ovarian masses. 31-40 years age group showed the highest propensity of occurrence of Ovarian Masses. Mucinous Cystadenoma was highly emerged most common benign Ovarian Mass in this study. [Int J Reprod Contracept Obstet Gynecol 2016; 5(11.000: 3802-3805

  10. A STUDY OF OVARIAN TUMOURS : CLINICAL AND PATHOLOGICAL CORRELATION

    Directory of Open Access Journals (Sweden)

    Uma Devi

    2015-10-01

    Full Text Available OBJECTIVE: To study incidence age distribution of benign and malignant ovarian tu mours in general population. METHODS AND MATERIAL : To study 120 patients with ovarian tumours in Govt . general hospital during June 2003 and June 2005. RESULTS: Clinical and pathological evaluation of all ovarian tumours was done and incidence, age distrib ution of various benign and malignant ovarian neoplasms were tabulated and compared with other studies. CONCLUSIONS: Most common ovarian tumours are benign tumours and serous cystadenoma is the commonest benign tumour and S erous cystadeno carcinoma is the most common malignant tumour.

  11. Evaluations of mosquito age grading techniques based on morphological changes.

    Science.gov (United States)

    Hugo, L E; Quick-Miles, S; Kay, B H; Ryan, P A

    2008-05-01

    Evaluations were made of the accuracy and practicality of mosquito age grading methods based on changes to mosquito morphology; including the Detinova ovarian tracheation, midgut meconium, Polovodova ovariole dilatation, ovarian injection, and daily growth line methods. Laboratory maintained Aedes vigilax (Skuse) and Culex annulirostris (Skuse) females of known chronological and physiological ages were used for these assessments. Application of the Detinova technique to laboratory reared Ae. vigilax females in a blinded trial enabled the successful identification of nulliparous and parous females in 83.7-89.8% of specimens. The success rate for identifying nulliparous females increased to 87.8-98.0% when observations of ovarian tracheation were combined with observations of the presence of midgut meconium. However, application of the Polovodova method only enabled 57.5% of nulliparous, 1-parous, 2-parous, and 3-parous Ae. vigilax females to be correctly classified, and ovarian injections were found to be unfeasible. Poor correlation was observed between the number of growth lines per phragma and the calendar age of laboratory reared Ae. vigilax females. In summary, morphological age grading methods that offer simple two-category predictions (ovarian tracheation and midgut meconium methods) were found to provide high-accuracy classifications, whereas methods that offer the separation of multiple age categories (ovariolar dilatation and growth line methods) were found to be extremely difficult and of low accuracy. The usefulness of the morphology-based methods is discussed in view of the availability of new mosquito age grading techniques based on cuticular hydrocarbon and gene transcription changes. PMID:18533427

  12. Hormone therapy and ovarian cancer

    DEFF Research Database (Denmark)

    Mørch, Lina Steinrud; Løkkegaard, Ellen; Andreasen, Anne Helms;

    2009-01-01

    CONTEXT: Studies have suggested an increased risk of ovarian cancer among women taking postmenopausal hormone therapy. Data are sparse on the differential effects of formulations, regimens, and routes of administration. OBJECTIVE: To assess risk of ovarian cancer in perimenopausal and postmenopau......CONTEXT: Studies have suggested an increased risk of ovarian cancer among women taking postmenopausal hormone therapy. Data are sparse on the differential effects of formulations, regimens, and routes of administration. OBJECTIVE: To assess risk of ovarian cancer in perimenopausal...... and postmenopausal women receiving different hormone therapies. DESIGN AND SETTING: Nationwide prospective cohort study including all Danish women aged 50 through 79 years from 1995 through 2005 through individual linkage to Danish national registers. Redeemed prescription data from the National Register...... bands included hormone exposures as time-dependent covariates. PARTICIPANTS: A total of 909,946 women without hormone-sensitive cancer or bilateral oophorectomy. MAIN OUTCOME MEASURE: Ovarian cancer. RESULTS: In an average of 8.0 years of follow-up (7.3 million women-years), 3068 incident ovarian...

  13. Primary Ovarian Insufficiency

    Science.gov (United States)

    ... health/premature-ovarian-failure/DS00843 International Premature Ovarian Failure Association: www.ipofa.org ... to further patient education on hormone related issues. Network Sponsors The Hormone ...

  14. Bilateral ovarian mixed epithelial adenocarcinoma in a postmenopausal woman with unilateral ovarian yolk sac tumor component

    OpenAIRE

    Qin CHEN; Chen, Xiaoduan

    2014-01-01

    Ovarian yolk sac tumors (YSTs) usually occur in the young women and have been rarely documented in perimenopausal and postmenopausal women. The different age distribution supposes their complex nomenclature and histogenesis. We report a case of bilateral ovarian epithelial carcinoma with right ovarian YST component in a postmenopausal woman. The patient was treated by surgery and adjuvant combination chemotherapy of taxol and carboplatin for 6 courses and has been clinically free of tumor for...

  15. Study on the relation between the degree of dental calcification and chronological age about Chinese Han nationality aged 6~18 years old groups of the female gender%中国汉族6~18周岁女性人群牙齿生长发育的年龄研究

    Institute of Scientific and Technical Information of China (English)

    田雪梅; 封华; 董迎春; 谭宇; 王晓明; 王昊; 韩冰; 庹琳; 王坚; 张继宗

    2011-01-01

    Objective This study was to explore the relation between degree of dental calcification and age in Chinese Han nationality adolescents and youths of the female gender, then to set up equations for estimating age by tooth.Methods The samples consisted of 6 923 pieces of digital orthopantomograms belonging to the groups aged 6 ~ 18 years old,accordance to the standard for grading the degree of dental calcification,the observers graded the low mandibular dental calcification degree showing in the samples, then dealt the data with SPSS 13.0 and set up the regression equations for estimating age;finally, a blind test was carried out based on 181 samples not used in the study.Results There was a perfect relation between chronological age and each tooth( r > 0.6 ), there were no significant statistic differences (P > 0.05 ) in the low mandibular dental calcification degree between homonymic teeth and there was a good correlation between them (r >0.93) ;the regression model used in the research was rational and the mean error between the estimated age and chronological age is 0.421 ± 0.272 year.Conclusion The methods used in this study shows a favorable foreground in estimating age for Chinese Han nationality groups aged 6 ~ 18 years old of the female gender in forensic practice.%目的 研究牙齿钙化程度与年龄的关系,建立利用牙齿推断中国汉族女性人群年龄的方程.方法 通过对6 923名6~18周岁汉族女性儿童及青少年全口曲面断层影像下领恒牙的钙化程度进行评分;将分级值及其对应的年龄输入SPSS软件进行分析,最终建立推断年龄的方程模型;从研究样本外随机抽取已知年龄的样本181例进行盲测.结果 牙齿钙化评分值与年龄相关分析结果相关系数r均大于0.6,同名牙评分值侧别间统计分析结果P>0.05且相关系数r均大于0.93,方程拟合优度检验R2=0.789,估计值标准误为1.28岁,盲测结果与真实年龄的平均误差为0.421±0

  16. Reference values in ovarian response to controlled ovarian stimulation throughout the reproductive period.

    Science.gov (United States)

    La Marca, Antonio; Grisendi, Valentina; Spada, Elena; Argento, Cindy; Milani, Silvano; Plebani, Maddalena; Seracchioli, Renato; Volpe, Annibale

    2014-01-01

    Abstract The age-related decline in ovarian response to gonadotropins has been well known since the beginning of ovarian stimulation in IVF cycles and has been considered secondary to the age-related decline in ovarian reserve. The objective of this study was to establish reference values and to construct nomograms of ovarian response for any specific age to gonadotropins in IVF/ICSI cycles. We analyzed our database containing information on IVF cycles. According to inclusion and exclusion criteria, a total of 703 patients were selected. Among inclusion criteria, there were regular menstrual cycle, treatment with a long GnRH agonist protocol and starting follicle-stimulating hormone (FSH) dose of at least 200 IU per day. To estimate the reference values of ovarian response, the CG-LMS method was used. A linear decline in the parameters of ovarian response with age was observed: the median number of oocytes decreases approximately by one every three years, and the median number of follicles >16 mm by one every eight years. The number of oocytes and growing follicles corresponding to the 5th, 25th, 50th, 75th and 95th centiles has been calculated. This study confirmed the well known negative relationship between ovarian response to FSH and female ageing and permitted the construction of nomograms of ovarian response.

  17. Chronology of eclipse "San Miao"

    Science.gov (United States)

    Liu, Ci-Yuan

    2001-06-01

    The ancient book "Mozi" (5th century BC) records: "In ancient times, the San Miao tribes were in disarray. The sun rose in the evening...King Yu vanquished them. "King Yu is a prehistoric person living in 23-19th century BC. The strange phenomena "sun rose in evening" was explained as a large solar eclipse at sunset by Pang. Therefore investigations on it may lead to an important progress of Chinese chronology. After an analysis on all similar records in Chinese history, we pay main attention to the relationship of eclipse computations with parameter "c", the long term of earth's rotation rate. We have computed all the solar eclipses in that period by the way similar to that used for investigating the "double dawn" eclipse. By change parameter "c" in reasonable range (28-36 sec/cy2), we have found 11 possible results listed in a table. One figure shows the eclipse maps and relative "double dawn/dusk" areas while another one illustrates how the parameter "c" affects the result. For an exact conclusion of King Yu's chronology, we need further progress from both side: history which may limit the King Yu's period and astronomy which may limit the possible range of parameter "c".

  18. Selective estrogen receptor modulators decrease reactive astrogliosis in the injured brain: Effects of aging and prolonged depletion of ovarian hormones

    OpenAIRE

    Barreto, G.; Santos-Galindo, M.; Diz-Chaves, Yolanda; Pernía, Olga; Carrero, P; Azcoitia, I.; Garcia-Segura, Luis M.

    2009-01-01

    After brain injury, astrocytes acquire a reactive phenotype characterized by a series of morphological and molecular modifications, including the expression of the cytoskeletal protein vimentin. Previous studies have shown that estradiol down-regulates reactive astrogliosis. In this study we assessed whether raloxifene and tamoxifen, two selective estrogen receptor modulators, have effects similar to estradiol in astrocytes. We also assessed whether aging and the timing of estrogenic therapy ...

  19. Concurrent cystic endometrial hyperplasia, ovarian luteoma and biliary cyst adenoma in an aged rabbit (Oryctolagus cuniculus):case report and literature review

    Institute of Scientific and Technical Information of China (English)

    Askari Nasrin; Akhtardanesh Baharak; Kheirandish Reza

    2012-01-01

    A 6-year-old female nulliparous Dutch Rabbit (Oryctolagus cuniculus) was presented in shock status with a history of abdominal distention, inappetance, lethargy, polydipsia, diarrhea and weight loss since 2 weeks ago. There was no breeding history. Radiographic survey showed increased soft tissue opacity dorsal to the urinary bladder and ventral to the colon on the lateral view consistent with uteromegaly and severe intestinal distention resembling intussusceptions. Conservative treatment was failed and the animal died. In necropsy, ileocecal intussusception was noted as the main death factor. Thickened uterine endometrium in both horns was observed and the uterus was filled with mucoid fluid. Both ovaries were multilobulated and distended. On the other hand, a small cyst sized 1.5 × 2.5 cm was diagnosed on the liver surface. Several samples were obtained from lesions for histopathological evaluation. Histopathologically, dilated cystic glands of variable size lined by densely packed epithelium and hyperplasia of the endometrium resulting in irregular folds or papillar projection into the lumen were evident and the sections of ovaries revealed ovarian luteoma that composed of polyhedral cells with pale stained vacuolated cytoplasm, centrally located nuclei with distinct cytoplasmic borders and the cytoplasm of cells contain lipid droplet. The occurrence of biliary cyst adenoma was confirmed by microscopic examination of the mass that composed of multicystic space in different sizes lined by flattened to cuboidal biliary epithelium with papillary projections. These cysts were seperated by variable amount of connective tissue. The lack of postmortem investigations in aged rabbits reduced the incidence of neoplastic disease diagnosis in this species. Whereas uterine adenecarcinoma and lymphosarcoma were commonly reported in rabbits, luteoma and biliary cyst adenoma that are well described in this case report were uncommon in rabbit medicine.

  20. Astronomical arguments in Newton's Chronology

    CERN Document Server

    Naze, Yael

    2012-01-01

    In his Chronology, Newton uses astronomical "evidence" to support its extreme rejuvenation of ancient times. These elements, having a scientific varnish, provide some credibility to the work. They have been fiercely debated for a century, with a gradual undermining of Newton's assumptions. However, this has not dented the prestige of the English scientist. ----- Dans sa Chronologie, Newton utilise des "preuves" astronomiques pour appuyer son rajeunissement extreme des epoques anciennes. Ces elements, au vernis scientifique, donnent une credibilite certaine a l'ensemble. Ils ont donc ete aprement discutes, les debats sapant petit a petit les hypotheses du savant anglais pour finalement porter un coup mortel a l'ensemble. Cela n'a toutefois pas entame le prestige du savant anglais.

  1. Tanshinones extend chronological lifespan in budding yeast Saccharomyces cerevisiae.

    Science.gov (United States)

    Wu, Ziyun; Song, Lixia; Liu, Shao Quan; Huang, Dejian

    2014-10-01

    Natural products with anti-aging property have drawn great attention recently but examples of such compounds are exceedingly scarce. By applying a high-throughput assay based on yeast chronological lifespan measurement, we screened the anti-aging activity of 144 botanical materials and found that dried roots of Salvia miltiorrhiza Bunge have significant anti-aging activity. Tanshinones isolated from the plant including cryptotanshione, tanshinone I, and tanshinone IIa, are the active components. Among them, cryptotanshinone can greatly extend the budding yeast Saccharomyces cerevisiae chronological lifespan (up to 2.5 times) in a dose- and the-time-of-addition-dependent manner at nanomolar concentrations without disruption of cell growth. We demonstrate that cryptotanshinone prolong chronological lifespan via a nutrient-dependent regime, especially essential amino acid sensing, and three conserved protein kinases Tor1, Sch9, and Gcn2 are required for cryptotanshinone-induced lifespan extension. In addition, cryptotanshinone significantly increases the lifespan of SOD2-deleted mutants. Altogether, those data suggest that cryptotanshinone might be involved in the regulation of, Tor1, Sch9, Gcn2, and Sod2, these highly conserved longevity proteins modulated by nutrients from yeast to humans.

  2. Steroid hormones profile during an ovarian synchronization procedure in different age categories of red deer hinds (Cervus elaphus L.

    Directory of Open Access Journals (Sweden)

    Šperanda Marcela

    2012-01-01

    Full Text Available The objective of the present study was to compare estradiol/progesterone ratios of different age categories of red deer hinds and use it as a predictor of estrus synchronization success and consequently conception rate. To accomplish this we used 38 red deer hinds to establish serum progesterone and estradiol levels in young (21 animals, mature (10 animals and old (7 animals hinds during the estrus synchronization procedure (transvaginal/cervical AI. The following estrus synchronization was used: at the start of the experiment each hind received a controlled intravaginal drug-releasing device (CIDR, Pharmacia&Upjohn, New Zealand containing 0.3 g of progesterone. The device was removed on day 11, simultaneously with an application of 250 IU of Pregnant Mare Serum Gonadotropin (PMSG, Folligon® Intervet International, Boxmeer, Holland. Transvaginal/ cervical AI (artificial insemination was performed 48 hours after CIDR withdrawal (day 13. Blood samples were obtained from the jugular vein using a Venoject® vacutainer without an anticoagulant for hormonal tests on the same experimental day (0, 11th and 13th day. A statistically (p<0.01 higher progesterone level was found in young hinds on the 11th day after controlled intravaginal drug-releasing device insertion. A significantly higher (p<0.01 estrogen level was observed in the young in regard to mature and old hinds on the expected day of estrus (13th day. Estradiol/progesterone ratios showed a statistically significant difference (p<0.01 on insemination day (13th day between old and young hinds (98.67 : 46.59 and between old and mature hinds (98.67 : 51.79. Out of a total of 38 hinds only 9 had their offspring, 6 of the young and 3 of the mature hinds.

  3. The Catacomb cultures of the North-West Caspian steppe : C-14 chronology, reservoir effect, and paleodiet

    NARCIS (Netherlands)

    Shishlina, N. I.; van der Plicht, J.; Hedges, R. E. M.; Zazovskaya, E. P.; Sevastyanov, V. S.; Chichagova, O. A.

    2007-01-01

    For the Bronze Age Catacomb cultures of the North-West Caspian steppe area in Russia, there is a conflict between the traditional relative archaeological chronology and the chronology based on radiocarbon dates. We show that this conflict can be explained largely by the fact that most dates have bee

  4. The WAIS Divide deep ice core WD2014 chronology - Part 2: Annual-layer counting (0-31 ka BP)

    Science.gov (United States)

    Sigl, Michael; Fudge, Tyler J.; Winstrup, Mai; Cole-Dai, Jihong; Ferris, David; McConnell, Joseph R.; Taylor, Ken C.; Welten, Kees C.; Woodruff, Thomas E.; Adolphi, Florian; Bisiaux, Marion; Brook, Edward J.; Buizert, Christo; Caffee, Marc W.; Dunbar, Nelia W.; Edwards, Ross; Geng, Lei; Iverson, Nels; Koffman, Bess; Layman, Lawrence; Maselli, Olivia J.; McGwire, Kenneth; Muscheler, Raimund; Nishiizumi, Kunihiko; Pasteris, Daniel R.; Rhodes, Rachael H.; Sowers, Todd A.

    2016-03-01

    We present the WD2014 chronology for the upper part (0-2850 m; 31.2 ka BP) of the West Antarctic Ice Sheet (WAIS) Divide (WD) ice core. The chronology is based on counting of annual layers observed in the chemical, dust and electrical conductivity records. These layers are caused by seasonal changes in the source, transport, and deposition of aerosols. The measurements were interpreted manually and with the aid of two automated methods. We validated the chronology by comparing to two high-accuracy, absolutely dated chronologies. For the Holocene, the cosmogenic isotope records of 10Be from WAIS Divide and 14C for IntCal13 demonstrated that WD2014 was consistently accurate to better than 0.5 % of the age. For the glacial period, comparisons to the Hulu Cave chronology demonstrated that WD2014 had an accuracy of better than 1 % of the age at three abrupt climate change events between 27 and 31 ka. WD2014 has consistently younger ages than Greenland ice core chronologies during most of the Holocene. For the Younger Dryas-Preboreal transition (11.595 ka; 24 years younger) and the Bølling-Allerød Warming (14.621 ka; 7 years younger), WD2014 ages are within the combined uncertainties of the timescales. Given its high accuracy, WD2014 can become a reference chronology for the Southern Hemisphere, with synchronization to other chronologies feasible using high-quality proxies of volcanism, solar activity, atmospheric mineral dust, and atmospheric methane concentrations.

  5. Impact of tumor chronology and tumor biology on lymph node metastasis in breast cancer

    OpenAIRE

    Smeets, Ann; Ryckx, Andries; Belmans, Ann; Wildiers, Hans; Neven, Patrick; Floris, Giuseppe; Schöffski, Patrick; Christiaens, Marie-Rose

    2013-01-01

    Synopsis The significance of nodal metastasis in breast cancer is under discussion. We investigated the impact of variables of tumor chronology and tumor biology on the presence of lymph node metastases. Purpose Lymph node involvement is the main prognostic factor in breast cancer. However, it is under discussion whether nodal metastasis in breast cancer only reflects the chronological age of the tumor or whether it is also a marker of tumor biology. The goal of our study was to investigate t...

  6. MASSIVE OVARIAN EDEMA – CASE REPORT OF A RARE PSEUDOTUMOUR

    Directory of Open Access Journals (Sweden)

    Archana

    2014-01-01

    Full Text Available Massive ovarian edema is a very rare disease characterized by a tumor like enlargement of the ovary. The presenting symptoms are non - specific and often the condition is mistaken for an ovarian neoplasm. A 28 year old nulligravid a lady , presented with chronic pain abdomen and irregular menses to our gynecological outpatient department. Ultrasound was suspicious of an ovarian neoplasm , but all biochemical parameters , including ovarian tumor markers were within normal limits. Considering the young age of the patient , laparotomy was done , and the mass excised. On histopathologi cal examination the diagnosis of massive ovarian edema was made. We present this case , not only because if its rarity , but also to stress on the fact that massive ovarian edema should be considered in the differential diagnosis of unilateral ovarian masses especially in young patients to avoid aggressive treatment as compromising fertility and hormonal function is always an issue

  7. Climate wavelet spectrum estimation under chronology uncertainties

    Science.gov (United States)

    Lenoir, G.; Crucifix, M.

    2012-04-01

    Several approaches to estimate the chronology of palaeoclimate records exist in the literature: simple interpolation between the tie points, orbital tuning, alignment on other data... These techniques generate a single estimate of the chronology. More recently, statistical generators of chronologies have appeared (e.g. OXCAL, BCHRON) allowing the construction of thousands of chronologies given the tie points and their uncertainties. These techniques are based on advanced statistical methods. They allow one to take into account the uncertainty of the timing of each climatic event recorded into the core. On the other hand, when interpreting the data, scientists often rely on time series analysis, and especially on spectral analysis. Given that paleo-data are composed of a large spectrum of frequencies, are non-stationary and are highly noisy, the continuous wavelet transform turns out to be a suitable tool to analyse them. The wavelet periodogram, in particular, is helpful to interpret visually the time-frequency behaviour of the data. Here, we combine statistical methods to generate chronologies with the power of continuous wavelet transform. Some interesting applications then come up: comparison of time-frequency patterns between two proxies (extracted from different cores), between a proxy and a statistical dynamical model, and statistical estimation of phase-lag between two filtered signals. All these applications consider explicitly the uncertainty in the chronology. The poster presents mathematical developments on the wavelet spectrum estimation under chronology uncertainties as well as some applications to Quaternary data based on marine and ice cores.

  8. Premature ovarian failure.

    Science.gov (United States)

    Vujović, Svetlana; Ivović, Miomira; Tancić-Gajić, Milina; Marina, Ljiljana; Barać, Marija; Arizanović, Zorana; Nenezić, Ana; Ivanisević, Maja; Micić, Jelena; Sajić, Silvija; Micić, Dragan

    2012-01-01

    Premature ovarian failure (POF) is the occurrence of hypergonadotropic hypoestrogenic amenorrhea in women under the age of forty years. It is idiopathic in 74-90% patients. Known cases can be divided into primary and secondary POF. In primary POF genetic aberrations can involve the X chromosome (monosomy, trisomy, translocations, deletions) or autosomes. Genetic mechanisms include reduced gene dosage and non-specific chromosome effects impairing meiosis, decreasing the pool of primordial follicles and increasing atresia due to apoptosis or failure of follicle maturation. Autoimmune ovarian damage is caused by alteration of T-cell subsets and T-cell mediated injury, increase of autoantibody producing B-cells, a low number of effector/cytotoxic lymphocyte, which decreases the number and activity of natural killer cells. Bilateral oophorectomy, chemotherapy, radiotherapy and infections cause the secondary POF. Symptoms of POF include irritability, nervousness, loss of libido, depression, lack of concentration, hot flushes, weight gaining, dry skin, vaginal dryness, frequent infections etc.The diagnosis is confirmed by the level of FSH of over 40 IU/L and estradiol below 50 pmol/L in women aged below 40 years. Biochemical and other hormonal analysis (free thyroxin, TSH, prolactin, testosterone), karyotype (libido. Sequential estrogen progestagen replacement therapy is the first line therapy for ovulation induction in those looking for pregnancy and after that oocyte donation will be advised. Appropriate estro-progestagen therapy improves the quality of life and prevents complications such as cardiovascular diseases, osteoporosis, stroke etc. PMID:23350261

  9. Maintenance of cellular ATP level by caloric restriction correlates chronological survival of budding yeast

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Joon-Seok; Lee, Cheol-Koo, E-mail: cklee2005@korea.ac.kr

    2013-09-13

    Highlights: •CR decreases total ROS and mitochondrial superoxide during the chronological aging. •CR does not affect the levels of oxidative damage on protein and DNA. •CR contributes extension of chronological lifespan by maintenance of ATP level -- Abstract: The free radical theory of aging emphasizes cumulative oxidative damage in the genome and intracellular proteins due to reactive oxygen species (ROS), which is a major cause for aging. Caloric restriction (CR) has been known as a representative treatment that prevents aging; however, its mechanism of action remains elusive. Here, we show that CR extends the chronological lifespan (CLS) of budding yeast by maintaining cellular energy levels. CR reduced the generation of total ROS and mitochondrial superoxide; however, CR did not reduce the oxidative damage in proteins and DNA. Subsequently, calorie-restricted yeast had higher mitochondrial membrane potential (MMP), and it sustained consistent ATP levels during the process of chronological aging. Our results suggest that CR extends the survival of the chronologically aged cells by improving the efficiency of energy metabolism for the maintenance of the ATP level rather than reducing the global oxidative damage of proteins and DNA.

  10. Maintenance of cellular ATP level by caloric restriction correlates chronological survival of budding yeast

    International Nuclear Information System (INIS)

    Highlights: •CR decreases total ROS and mitochondrial superoxide during the chronological aging. •CR does not affect the levels of oxidative damage on protein and DNA. •CR contributes extension of chronological lifespan by maintenance of ATP level -- Abstract: The free radical theory of aging emphasizes cumulative oxidative damage in the genome and intracellular proteins due to reactive oxygen species (ROS), which is a major cause for aging. Caloric restriction (CR) has been known as a representative treatment that prevents aging; however, its mechanism of action remains elusive. Here, we show that CR extends the chronological lifespan (CLS) of budding yeast by maintaining cellular energy levels. CR reduced the generation of total ROS and mitochondrial superoxide; however, CR did not reduce the oxidative damage in proteins and DNA. Subsequently, calorie-restricted yeast had higher mitochondrial membrane potential (MMP), and it sustained consistent ATP levels during the process of chronological aging. Our results suggest that CR extends the survival of the chronologically aged cells by improving the efficiency of energy metabolism for the maintenance of the ATP level rather than reducing the global oxidative damage of proteins and DNA

  11. Ovarian response during IVF cycle following laparascopic cystectomy of ovarian endometrioma

    Directory of Open Access Journals (Sweden)

    Nasrin Moghadami Tabrizi

    2013-07-01

    Full Text Available Background: Endometrioma of ovary is one of the common diseases during reproductive age and the effect of laparoscopic cystectomy of endometrioma on infertility is still matter of debate. We designed this case control study to evaluate the ovarian response to controlled ovarian hyperstimulation during IVF (In vitro fertilization cycle following laparoscopic unilateral cystectomy of endometrioma. Methods: In a case control study, we enrolled 30 women with history of unilateral laparoscopic cystectomy of ovarian endometrioma in stripping method who underwent IVF cycle in women Hospital, 2009-2012. The numbers of follicles in response to controlled ovarian hyperstimulation during IVF cycle in the ovary with history of  unilateral laparoscopic cystectomy of endometrioma were compared with those from the contralateral ovary. Results: The mean age (±SD of patients was 32.3 (±3.4. The mean (±SD diameter of excised ovarian endometrioma was 42.4 (±10.4 mm. Interval since ovarian surgery to induction ovulation was 2.7 (±2.6 years. Mean number of follicles in the ovary with history of unilateral laparoscopic cystectomy of endometrioma was 2.5 (±1.2 with the range of 1 to 5 and in the control ovary 3.9 (±1.4 with the range of 1 to 6. There was significant difference in the number of follicles in the ovary with laparascopic cystectomy of endometrioma compared with opposite one (P<0.001.Conclusion: Laparoscopic cystectomy for unilateral endometrioma is associated with a reduced ovarian response to controlled ovarian hyperstimulation during IVF cycle. We did not find any statistically significant difference in reduced ovarian response with regard to patients age, body mass index, size and location of the cyst, and time duration since ovarian cystectomy.

  12. Prehistoric chronology of Madhya Pradesh

    Digital Repository Service at National Institute of Oceanography (India)

    Gaur, A.S.

    Madhya Pradesh is very rich in archaeological wealth, with availability of remains starting from Early Stone Age to Historical period. Several Stone Age sites have been brought to light specially in districts of Hoshangabad, Narsinghpur, Mandla...

  13. Improved selection of cortical ovarian strips for autotransplantation of ovarian tissue using full-field optical coherence tomography (FFOCT)

    Science.gov (United States)

    Stegehuis, Paulien L.; Peters, Inge T. A.; Eggermont, Jeroen; Kuppen, Peter J. K.; Trimbos, J. Baptist; Lelieveldt, Boudewijn P. F.; van de Velde, Cornelis J. H.; Bosse, Tjalling; Dijkstra, Jouke; Vahrmeijer, Alexander L.

    2016-02-01

    Premature ovarian failure is a major concern in women of reproductive age who undergo gonadotoxic cancer treatment. Autotransplantation of frozen-thawed cortical ovarian tissue allows the immediate start of cancer treatment, but risks reintroduction of cancer. Current tumor detection methods compromise the ovarian tissue's viability and can therefore only be used to exclude the presence of metastases in the cortical ovarian strips that are not transplanted. A non-invasive method is needed that can be used to exclude metastases in the actual ovarian autografts without affecting the tissue's viability. In this study we applied FFOCT - a non-fixative technique that uses white light interferometry to make highresolution images (1μm isotropic) of fresh tissue - to study healthy and malignant ovarian tissue. We created an image atlas of healthy ovarian tissues from premenopausal patients and ovarian tissues with breast cancer metastases. To get the best possible match between hematoxylin-and-eosin stained slides and FFOCT images formalinfixed paraffin-embedded tissue samples were deparaffinized and FFOCT images were acquired within a few minutes. FFOCT images were compared with histology images. All normal structures such as follicles in all phases, inclusion cysts, blood vessels, corpora lutea, and corpora albicantia were clearly recognizable. Ovarian metastases could be well distinguished from normal ovarian tissue. FFOCT is a promising technique in the field of fertility preservation: metastases can be detected and additionally cortical ovarian strips can be selected on the basis of high follicle density.

  14. Extravehicular Activity Fact Sheet: An EVA Chronology

    Data.gov (United States)

    National Aeronautics and Space Administration — Walking to Olympus: An EVA Chronology chronicles the 154 EVAs conducted from March 1965 to April 1997. It is intended to make clear the crucial role played by EVA...

  15. Primary ovarian insufficiency

    NARCIS (Netherlands)

    De Vos, Michel; Devroey, Paul; Fauser, Bart C. J. M.

    2010-01-01

    Primary ovarian insufficiency is a subclass of ovarian dysfunction in which the cause is within the ovary. In most cases, an unknown mechanism leads to premature exhaustion of the resting pool of primordial follicles. Primary ovarian insufficiency might also result from genetic defects, chemotherapy

  16. Ovarian cancer and smoking

    DEFF Research Database (Denmark)

    Beral, V; Gaitskell, K; Hermon, C;

    2012-01-01

    Smoking has been linked to mucinous ovarian cancer, but its effects on other ovarian cancer subtypes and on overall ovarian cancer risk are unclear, and the findings from most studies with relevant data are unpublished. To assess these associations, we review the published and unpublished evidence....

  17. Construction of reliable radiocarbon-based chronologies for speleothems

    Science.gov (United States)

    Lechleitner, Franziska; Fohlmeister, Jens; McIntyre, Cameron; Baldini, Lisa M.; Jamieson, Robert A.; Hercman, Helena; Gasiorowski, Michal; Pawlak, Jacek; Stefaniak, Krzysztof; Socha, Pawel; Eglinton, Timothy I.; Baldini, James U. L.

    2016-04-01

    Speleothems have become one of the most widely applied archives for paleoclimate research. One of their key advantages is their amenability for U-series dating, often producing excellent high precision chronologies. However, stalagmites with high detrital Th or very low U concentrations are problematic to date using U-series, and sometimes need to be discarded from further paleoclimate analysis. Radiocarbon chronologies could present an alternative for stalagmites that cannot be dated using U-series, if offsets from the "dead carbon fraction" (DCF) can be resolved. The DCF is a variable reservoir effect introduced by the addition of 14C-dead carbon from host rock dissolution and soil organic matter. We present a novel age modeling technique that provides accurate 14C-based chronologies for stalagmites. As this technique focuses on the long-term decay pattern of 14C, it is only applicable on stalagmites that show no secular variability in their 14C-depth profiles, but is independent of short-term DCF variations. In order to determine whether a stalagmite is suitable for this method without direct knowledge of long-term trends in the DCF, we highlight how other geochemical proxies (δ13C, Mg/Ca) can provide additional information on changes in karst hydrology, soil conditions, and climate that would affect DCF. We apply our model on a previously published U-Th dated stalagmite 14C dataset from Heshang Cave, China with excellent results, followed by a previously 'undateable' stalagmite from southern Poland.

  18. Densidade mineral óssea, função pulmonar, idade cronológica e idade de diagnóstico em crianças e adolescentes com fibrose cística Bone mineral density, pulmonary function, chronological age, and age at diagnosis in children and adolescents with cystic fibrosis

    Directory of Open Access Journals (Sweden)

    Márcio V.F. Donadio

    2013-04-01

    . First, demographic data were collected and, subsequently, patients underwent a spirometric test. All patients answered the Cystic Fibrosis Quality of Life Questionnaire (CFQ and underwent the six-minute walk test (6MWT and bone densitometry (DXA. RESULTS: A total of 25 CF patients were included, of which 56% were males. The mean age was 12.3±3.4 years; mean height was 149.2±14.4 cm; and mean weight was 44.4±13.9 kg. Most results on pulmonary function and bone mineral density (BMD were within normal limits. The mean forced expiratory volume in one second (FEV1 was 92.5±23.6 (% of predicted, mean forced vital capacity (FVC was 104.4±21.3 (% of predicted, and mean BMD z-score was 0.1±1.0. BMD was moderately correlated with FEV1 (r = 0.43, p = 0.03 and FVC (r = 0.57, p = 0.003. Regarding chronological age and age at diagnosis, a moderate and inverse correlation was also found (r = -0.55, p = 0.004 ; r = -0.57, p = 0.003, respectively. However, no significant correlations were found with the data from CFQ, 6MWT, and body mass index. CONCLUSION: Most patients had BMD within normal limits and presented a positive correlation with pulmonary function, as well as a negative correlation with chronological age and age at diagnosis.

  19. Mars chronology: assessing techniques for quantifying surficial processes

    Science.gov (United States)

    Doran, Peter T.; Clifford, Stephen M.; Forman, Steven L.; Nyquist, Larry; Papanastassiou, Dimitri A.; Stewart, Brian W.; Sturchio, Neil C.; Swindle, Timothy D.; Cerling, Thure; Kargel, Jeff

    2004-01-01

    Currently, the absolute chronology of Martian rocks, deposits and events is based mainly on crater counting and remains highly imprecise with epoch boundary uncertainties in excess of 2 billion years. Answers to key questions concerning the comparative origin and evolution of Mars and Earth will not be forthcoming without a rigid Martian chronology, enabling the construction of a time scale comparable to Earth's. Priorities for exploration include calibration of the cratering rate, dating major volcanic and fluvial events and establishing chronology of the polar layered deposits. If extinct andor extant life is discovered, the chronology of the biosphere will be of paramount importance. Many radiometric and cosmogenic techniques applicable on Earth and the Moon will apply to Mars after certain baselines (e.g. composition of the atmosphere, trace species, chemical and physical characteristics of Martian dust) are established. The high radiation regime may pose a problem for dosimetry-based techniques (e.g. luminescence). The unique isotopic composition of nitrogen in the Martian atmosphere may permit a Mars-specific chronometer for tracing the time-evolution of the atmosphere and of lithic phases with trapped atmospheric gases. Other Mars-specific chronometers include measurement of gas fluxes and accumulation of platinum group elements (PGE) in the regolith. Putting collected samples into geologic context is deemed essential, as is using multiple techniques on multiple samples. If in situ measurements are restricted to a single technique it must be shown to give consistent results on multiple samples, but in all cases, using two or more techniques (e.g. on the same lander) will reduce error. While there is no question that returned samples will yield the best ages, in situ techniques have the potential to be flown on multiple missions providing a larger data set and broader context in which to place the more accurate dates.

  20. Premature ovarian failure

    Directory of Open Access Journals (Sweden)

    Vujović Svetlana

    2012-01-01

    Full Text Available Premature ovarian failure (POF is the occurrence of hypergonadotropic hypoestrogenic amenorrhea in women under the age of forty years. It is idiopathic in 74-90% patients. Known cases can be divided into primary and secondary POF. In primary POF genetic aberrations can involve the X chromosome (monosomy, trisomy, translocations, deletions or autosomes. Genetic mechanisms include reduced gene dosage and non-specific chromosome effects impairing meiosis, decreasing the pool of primordial follicles and increasing atresia due to apoptosis or failure of follicle maturation. Autoimmune ovarian damage is caused by alteration of T-cell subsets and T-cell mediated injury, increase of autoantibody producing B-cells, a low number of effector/cytotoxic lymphocyte, which decreases the number and activity of natural killer cells. Bilateral oophorectomy, chemotherapy, radiotherapy and infections cause the secondary POF. Symptoms of POF include irritability, nervousness, loss of libido, depression, lack of concentration, hot flushes, weight gaining, dry skin, vaginal dryness, frequent infections etc. The diagnosis is confirmed by the level of FSH of over 40 IU/L and estradiol below 50 pmol/L in women aged below 40 years. Biochemical and other hormonal analysis (free thyroxin, TSH, prolactin, testosterone, karyotype (<30 years of age, ultrasound of the breasts and pelvis are advisable. Optimal therapy is combined estrogen progestagen therapy given in a sequential rhythm, after excluding absolute contraindications. Testosterone can be added to adnexectomized women and those with a low libido. Sequential estrogen progestagen replacement therapy is the first line therapy for ovulation induction in those looking for pregnancy and after that oocyte donation will be advised. Appropriate estro-progestagen therapy improves the quality of life and prevents complications such as cardiovascular diseases, osteoporosis, stroke etc.

  1. Hormone therapy and different ovarian cancers

    DEFF Research Database (Denmark)

    Mørch, Lina Steinrud; Løkkegaard, Ellen; Andreasen, Anne Helms;

    2012-01-01

    Postmenopausal hormone therapy use increases the risk of ovarian cancer. In the present study, the authors examined the risks of different histologic types of ovarian cancer associated with hormone therapy. Using Danish national registers, the authors identified 909,946 women who were followed from...... 1995-2005. The women were 50-79 years of age and had no prior hormone-sensitive cancers or bilateral oophorectomy. Hormone therapy prescription data were obtained from the National Register of Medicinal Product Statistics. The National Cancer and Pathology Register provided data on ovarian cancers......, including information about tumor histology. The authors performed Poisson regression analyses that included hormone exposures and confounders as time-dependent covariates. In an average of 8.0 years of follow up, 2,681 cases of epithelial ovarian cancer were detected. Compared with never users, women...

  2. Ovarian reserve tests in the prediction of the fertile lifespan and current fertility

    NARCIS (Netherlands)

    Depmann, M

    2016-01-01

    Widely used ovarian reserve tests do not predict age at menopause or current fertility This thesis assesssed the capacity of ovarian reserve tests in the prediction of the fertile life span and current fertility. Ovarian reserve tests of interest were anti-Müllerian hormone (AMH), the antral follicl

  3. On the Astronomical Records and Babylonian Chronology

    CERN Document Server

    Gurzadyan, V G

    2000-01-01

    We outline the priority of high quality data of astronomical content as our strategy for the analysis of the ancient astronomical records in the search of the absolute chronology of the Near East in II millennium BC. The correspondingly defined set of data for two lunar eclipses of EAE 20 and 21 tablets linked to Ur III period enables us the choice of eclipses of 27 June 1954 BC and 17 March 1912 BC; here the information on the exit position of the darkening of the lunar disk acts as a crucial informator survived in the records. We then discuss why the 56/64 year Venus cycle cannot be traced in the Venus Tablet and therefore cannot serve as an anchor for the search of chronologies. The month length method is discussed as well. In sum the available data support the Ultra-Low Chronology proposed in the book by H.Gasche, J.A.Armstrong, S.W.Cole and V.G.Gurzadyan, "Dating the Fall of Babylon" (1998) and, particularly, leave no astronomical background for the High Chronology. Ultra-Low Chronology is supported also...

  4. Ovarian tumors among Nigerian females: A private practice experience in Benin-City, Nigeria

    OpenAIRE

    Gerald Dafe Forae; Jonathan Umezulike Aligbe

    2016-01-01

    Background: Ovarian tumors ranked high among gynecological tumor globally. Reports have it that ovarian tumors cut across all age groups, but more common in adult females. Currently, ovarian cancer is the 4th most common cancer in terms of incidence and mortality patterns in women globally. To highlight the frequency and histological types of ovarian tumors in a private practice establishment in Benin-City, Southern Nigeria. Materials and Methods: Hematoxylin and eosin stained-slides of ovari...

  5. Environmental and developmental origins of ovarian reserve.

    Science.gov (United States)

    Richardson, M C; Guo, M; Fauser, B C J M; Macklon, N S

    2014-01-01

    BACKGROUND Oocyte number is established early in life before a gradual loss of this ovarian reserve during reproductive life until oocyte availability becomes limiting at the menopause. Although there is a large genetic component to the ovarian reserve achieved before birth, other influences including the maternal endocrine and nutritional milieu, and environmental factors may represent important developmental determinants. Environmental and nutritional factors may also modify the downward trajectory of ovarian reserve in adult life. The combination of these early and later life influences has the potential to lead to diminished ovarian reserve, compromising fertility in later reproductive years and altering age at natural menopause. METHODS Literature searches of the ISI Web of Knowledge database were carried out using the main terms 'ovarian reserve' and 'menopause AND age' in conjunction with a range of other terms encompassing a variety of factors with potential effects on ovarian reserve. The various searches were inspected manually and the relevant papers selected for critical analysis and interpretation. RESULTS Evidence was identified supporting the view that elevated prenatal androgens have an adverse effect on the early establishment of ovarian reserve, although the implications for ovarian reserve in the polycystic ovary syndrome (which may also be programmed through prenatal androgen exposure) remain uncertain. Recent evidence is cited suggesting that effects of maternal nutrient restriction on ovarian reserve may also involve changes in prenatal androgen exposure. A general rationale is developed through examination of evidence which emphasizes the roles of the aryl hydrocarbon receptor (AHR) and the estrogen receptor (ER) systems in ovarian reserve modulation. Because of their similarity to the natural ligands, many environmental compounds have the ability to bind to these receptors (albeit at lower affinities) and thereby have the potential to

  6. Laparoscopic ovarian drilling by diathermy for ovulation induction in infertile women with polycystic ovarian syndrome

    International Nuclear Information System (INIS)

    Background: Polycystic ovarian syndrome (PCOS) is the commonest cause of secondary infertility. Laparoscopic ovarian drilling has widely been used for induction of ovulation in polycystic ovarian syndrome patients resistant to clomiphene citrate. 80% patients ovulated after treatment and 60% patient conceived either spontaneously or after treatment with medication to which they are previously resistant. Purpose: The aim of the present study was to see the effectiveness of laparoscopic ovarian drilling (LOD) with monopolar diathermy on pregnancy outcome in infertile women with polycystic ovarian syndrome (PCOS). Design: Descriptive cross sectional study. Intervention: Laparoscopic ovarian drilling. Main Outcome Measures: Pregnancy, ovulation rate. Material and Methods: This study was carried out in the department of Gynae and Obstetrics in Sharif Medical City Hospital from January, 2007 to January, 2009. The inclusion criteria for laparoscopy ovarian drilling (LOD) were those infertile women between the age group of 25 - 38 years who meet the criteria for PCOS and who are resistant to clomiphene citrate and injectable gonadotrophins. A total of 30 women were booked for laparoscopic ovarian drilling after having informed consent for procedure. Response to therapy was assessed in term of pregnancy outcome and ovulation rate for 1 year after therapy. Results: A total of 30 patients were booked for laparoscopic ovarian drilling from January, 2007 to January, 2009. The mean age of study group was 30 years +- SD 4.7791. Cumulative ovulation rate was observed in 22 patients (73%), out of which spontaneous ovulation occurred in 18 patients (80%), and after ovulation induction therapy in 4 patients (18%). Eleven patients (37%) conceived in two year duration. Spontaneous conception without any treatment was observed in 7 patients (63%); however 4 patients (37%) require further assistance with combined therapy of clomiphene citrate and injectable gonadotrophins after failure

  7. CT imaging of ovarian yolk sac tumor with emphasis on differential diagnosis.

    Science.gov (United States)

    Li, Yang-Kang; Zheng, Yu; Lin, Jian-Bang; Xu, Gui-Xiao; Cai, Ai-Qun; Zhou, Xiu-Guo; Zhang, Guo-Jun

    2015-01-01

    Ovarian yolk sac tumors (YSTs) are rare neoplasms. No radiological study has been done to compare the imaging findings between this type of tumor and other ovarian tumors. Here we analyzed the CT findings of 11 pathologically proven ovarian YSTs and compared their imaging findings with 18 other types of ovarian tumors in the same age range. Patient age, tumor size, tumor shape, ascites and metastasis of two groups did not differ significantly (P > 0.05). A mixed solid-cystic nature, intratumoral hemorrhage, marked enhancement and dilated intratumoral vessel of two groups differed significantly (P ovarian tumors. PMID:26074455

  8. Ovarian tumors secreting insulin.

    Science.gov (United States)

    Battocchio, Marialberta; Zatelli, Maria Chiara; Chiarelli, Silvia; Trento, Mariangela; Ambrosio, Maria Rosaria; Pasquali, Claudio; De Carlo, Eugenio; Dassie, Francesca; Mioni, Roberto; Rebellato, Andrea; Fallo, Francesco; Degli Uberti, Ettore; Martini, Chiara; Vettor, Roberto; Maffei, Pietro

    2015-08-01

    Combined ovarian germ cell and neuroendocrine tumors are rare. Only few cases of hyperinsulinism due to ovarian ectopic secretion have been hypothesized in the literature. An ovarian tumor was diagnosed in a 76-year-old woman, referred to our department for recurrent hypoglycemia with hyperinsulinism. In vivo tests, in particular fasting test, rapid calcium infusion test, and Octreotide test were performed. Ectopic hyperinsulinemic hypoglycemia was demonstrated in vivo and hypoglycemia disappeared after hysteroadnexectomy. Histological exam revealed an ovarian germ cell tumor with neuroendocrine and Yolk sac differentiation, while immunostaining showed insulin positivity in neuroendocrine cells. A cell culture was obtained by tumoral cells, testing Everolimus, and Pasireotide. Insulin was detected in cell culture medium and Everolimus and Pasireotide demonstrated their potentiality in reducing insulin secretion, more than controlling cell viability. Nine cases of hyperinsulinism due to ovarian ectopic secretion reported in literature have been reviewed. These data confirm the ovarian tissue potentiality to induce hyperinsulinemic hypoglycemic syndrome after neoplastic transformation. PMID:25896552

  9. Ultrasonographic findings of ovarian teratomas

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Il Gi; Kwak, Dong Yeob; Kim, Si Woon; Lee, Jong Gil [Fatima Hospital, Taegu (Korea, Republic of)

    1986-04-15

    24 cases of surgically proven ovarian teratomas were analyzed. 1. The most prevalent age group was 3rd decades (57%). 2. The size of most tumors falls into 5-15cm (96%). 3. The site of involvement was more common on left side than right. 4. Well developed teeth or bones were identified in 9 patients on simple abdominal films (39%). 5. Ultrasonographic findings of the tumors were purely cystic in 3 cases (12.5%), mixed in 15 cases (62.5%), and solid in 6 cases (25%). 6. Among mixed typed masses, predominant cystic tumors were 11 cases, and the remained (4 cases) were predominantly solid type. 7. Various ultrasonic findings were seen such as hair-fluid level, linear echoes, scattered echoes, nodular intermixed dense echoes, papillary echogenic mass, and calcifications. 8. Echogenic nodular foci on nonindependent portion were considered to be a helpful diagnostic sign of ovarian teratomas.

  10. Unbalanced estrogen metabolism in ovarian cancer.

    Science.gov (United States)

    Zahid, Muhammad; Beseler, Cheryl L; Hall, James B; LeVan, Tricia; Cavalieri, Ercole L; Rogan, Eleanor G

    2014-05-15

    Greater exposure to estrogens is a risk factor for ovarian cancer. To investigate the role of estrogens in ovarian cancer, a spot urine sample and a saliva sample were obtained from 33 women with ovarian cancer and 34 age-matched controls. Thirty-eight estrogen metabolites, conjugates and DNA adducts were analyzed in the urine samples using ultraperformance liquid chromatography/tandem mass spectrometry, and the ratio of adducts to metabolites and conjugates was calculated for each sample. The ratio of depurinating estrogen-DNA adducts to estrogen metabolites and conjugates was significantly higher in cases compared to controls (p < 0.0001), demonstrating high specificity and sensitivity. DNA was purified from the saliva samples and analyzed for genetic polymorphisms in the genes for two estrogen-metabolizing enzymes. Women with two low-activity alleles of catechol-O-methyltransferase plus one or two high-activity alleles of cytochrome P450 1B1 had higher levels of estrogen-DNA adducts and were more likely to have ovarian cancer. These findings indicate that estrogen metabolism is unbalanced in ovarian cancer and suggest that formation of estrogen-DNA adducts plays a critical role in the initiation of ovarian cancer. PMID:24170413

  11. Secondary ovarian tumors: Evaluation of 44 cases

    Directory of Open Access Journals (Sweden)

    Sevgiye KAÇAR ÖZKARA

    2007-09-01

    Full Text Available Secondary ovarian tumors compose 3-8% of all, and 10-30% of malignant ovarian tumors. Histopathological features of SOT diagnosed in our department in 10-year period are discussed. Macroscopical, microscopical, immunohistochemical and cytopathological features of secondary ovarian tumors diagnosed between 1997- 2006 were re-evaluated. Additional histochemical and immunohistochemical studies were applied to find the primaries. Data was statistically evaluated. Totally, 44 secondary ovarian tumors had been diagnosed within this period. The mean age of the patients was 52.9 years; the mean tumor diameter was 103.7 mm.The primary was gastrointestinal system in 50% of the cases. Ten of them (22.7% were metastases of signet ring cell carcinoma of stomach (Kruckenberg tumor while 9 cases (20.5% were from colorectal and three (6.8% were from appendiceal adenocarcinomas. 27.3% of our cases were originated from genital tract. Synchronous endometrioid adenocarcinomas of corpus uteri and ovary were seen in six cases (13.6%. Ovarian involvement of serous carcinomas of corpus uteri was seen in five (11.4% cases. Ovarian metastases of breast carcinoma in four cases (9.1% were seen while the ovarian involvement of adrenal cortical and tubal carcinomas was observed in one case, each. The primary was peritoneal surface in five (11.4% of the cases. Tumors were bilateral in 65.9% of the cases, and there was statistically significant correlation between the bilaterality rate of the tumors and the primary (p=0.015.The more precise diagnosis of secondary ovarian tumors could be reached by evaluation of clinical, surgical, macroscopical, microscopical, cytopathological and immunohistochemical findings together.

  12. Pathobiology of ovarian carcinomas

    Institute of Scientific and Technical Information of China (English)

    Mojgan Devouassoux-Shisheboran; Catherine Genestie

    2015-01-01

    Ovarian tumors comprise a heterogeneous group of lesions, displaying distinct tumor pathology and oncogenic potentiel. These tumors are subdivided into three main categories: epithelial, germ cell, and sex-cord stromal tumors. We report herein the newly described molecular abnormalities in epithelial ovarian cancers (carcinomas). Immunohistochemistry and molecular testing help pathologists to decipher the significant heterogeneity of this disease. Our better understanding of the molecular basis of ovarian carcinomas represents the first step in the development of targeted therapies in the near future.

  13. Study on the relation between the degree of dental calcification and chronological age about Chinese Han nationality 6~18 years old male groups%中国汉族6~18周岁男性牙齿生长发育的年龄研究

    Institute of Scientific and Technical Information of China (English)

    田雪梅; 封华; 董迎春; 谭宇; 王晓明; 王昊; 韩冰; 庹琳; 王坚; 张继宗

    2011-01-01

    Objective This study was to explore the relation between degree of dental calcification and age on Chinese Han nationality adolescents and youths, then to set up equations for estimating age by digital orthopantomogram.Methods In accordance with the standard for grading the degree of dental calcification, the observer graded the degree of low mandibular dental calcification showing in digital orthopantomogram samples selected from 6 568 objects age range 6 ~18 years old,then dealt the figures with SPSS 13.0,in the end,established the regression equations for estimating age; besides, a blind test was done based on 160 pieces of digital orthopantomogram.Results There were no significant statistic differences in the low mandibular dental calcification degree between homonymic teeth, the nonparametric correlations between chronological age and dental calcification were above 0.7, the mean error between estimated age and chronological age was 0.423 ± 0.269 year.Conclusion The method set up in this study was reliable and would play an important role in estimating age for Chinese Han nationality adolescents and youths aged 6 ~ 18 years old in forensic science for male.%目的 研究牙齿钙化程度与年龄的关系,建立利用牙齿钙化程度推断中国汉族6~18周岁男性年龄的方程.方法 通过对6 568名6~18周岁汉族男性全口曲面断层影像上牙齿的钙化程度进行评分;将分级值及其对应年龄输入SPSS软件进行分析,建立推断年龄的方程模型;从研究样本外随机抽取已知年龄的样本160例进行盲测.结果 同名牙齿钙化评分值侧别间秩合检验结果P>0.05;下颌左侧恒牙钙化评分值与年龄相关分析结果r值均在0.7以上,下颌同名牙间相关系数r均在0.9以上;所建回归模型拟合优度R2=0.828,估计值标准误为1.23岁;盲测平均误差为0.423±0.269岁.结论 本研究所建立的方法准确可靠,可用于中国汉族6~18周岁男性人群的年龄推断.

  14. Premature ovarian insufficiency: Pathogenesis and management

    Directory of Open Access Journals (Sweden)

    Anna J Fenton

    2015-01-01

    Full Text Available The term premature ovarian insufficiency (POI describes a continuum of declining ovarian function in a young woman, resulting in an earlier than average menopause. It is a term that reflects the variable nature of the condition and is substantially less emotive than the formerly used "premature ovarian failure" which signaled a single event in time. Contrary to the decline in the age of menarche seen over the last 3-4 decades there has been no similar change in the age of menopause. In developed nations, the average age for cessation of menstrual cycles is 50-52 years. The age is younger among women from developing nations. Much has been written about POI despite a lack of good data on the incidence of this condition. It is believed that 1% of women under the age of 40 years and 0.1% under the age of 30 years will develop POI. Research is increasingly providing information about the pathogenesis and treatments are being developed to better preserve ovarian function during cancer treatment and to improve fertility options. This narrative review summarizes the current literature to provide an approach to best practice management of POI.

  15. An Introduction to The Royan Human Ovarian Tissue Bank

    Science.gov (United States)

    Abtahi, Naeimeh Sadat; Ebrahimi, Bita; Fathi, Rouhollah; Khodaverdi, Sepideh; Mehdizadeh Kashi, Abolfazl; Valojerdi, Mojtaba Rezazadeh

    2016-01-01

    From December 2000 until 2010, the researchers at Royan Institute conducted a wide range of investigations on ovarian tissue cryopreservation with the intent to provide fertility pres- ervation to cancer patients that were considered to be candidates for these services. In 2010, Royan Institute established the Royan Human Ovarian Tissue Bank as a subgroup of the Embryology Department. Since its inception, approximately 180 patients between the ages of 747 years have undergone consultations. Ovarian samples were cryopreserved from 47 patients (age: 7-35 years) diagnosed with cervical adenocarcinoma (n=9); breast carcinoma (n=7), Ewing’s sarcoma (n=7), opposite side ovarian tumor (n=7), endometrial adenocarci- noma (n=4), malignant colon tumors (n=3), as well as Hodgkin’s lymphoma, major thalas- semia and acute lymphoblastic leukemia (n=1-2 patients for each disease). Additionally, two patients requested ovarian tissue transplantation after completion of their treatments. PMID:27441061

  16. Risk of ovarian cancer in women with first-degree relatives with cancer

    DEFF Research Database (Denmark)

    Soegaard, Marie; Frederiksen, Kirsten; Jensen, Allan;

    2009-01-01

    OBJECTIVE: To assess the risk of ovarian cancer in women with first-degree relatives with cancer at one of the four most frequent hereditary sites based on validated cancer diagnoses and to examine the association according to age at diagnosis of ovarian cancer and histology. DESIGN: Case......-control study. SETTING AND POPULATION: First-degree relatives of 554 women with invasive epithelial ovarian cancer and 1,564 controls were included. METHODS: Analyses were performed using multiple logistic regression models. RESULTS: Ovarian cancer in a first-degree relative was significantly associated...... with ovarian cancer family history tended to be with non-mucinous tumors. Breast cancer in one first-degree female relative was not significantly associated with risk of ovarian cancer. CONCLUSION: Ovarian cancer in a first-degree relative is a very strong predictor of epithelial ovarian cancer, especially...

  17. Synergistic Effect of High Charge and Energy Particle Radiation and Chronological Age on Biomarkers of Oxidative Stress and Tissue Degeneration: A Ground-Based Study Using the Vertebrate Laboratory Model Organism Oryzias latipes

    International Nuclear Information System (INIS)

    High charge and energy (HZE) particles are a main hazard of the space radiation environment. Uncertainty regarding their health effects is a limiting factor in the design of human exploration-class space missions, that is, missions beyond low earth orbit. Previous work has shown that HZE exposure increases cancer risk and elicits other aging-like phenomena in animal models. Here, we investigate how a single exposure to HZE particle radiation, early in life, influences the subsequent age-dependent evolution of oxidative stress and appearance of degenerative tissue changes. Embryos of the laboratory model organism, Oryzias latipes (Japanese medaka fish), were exposed to HZE particle radiation at doses overlapping the range of anticipated human exposure. A separate cohort was exposed to reference γ-radiation. Survival was monitored for 750 days, well beyond the median lifespan. The population was also sampled at intervals and liver tissue was subjected to histological and molecular analysis. HZE particle radiation dose and aging contributed synergistically to accumulation of lipid peroxidation products, which are a marker of chronic oxidative stress. This was mirrored by a decline in PPARGC1A mRNA, which encodes a transcriptional co-activator required for expression of oxidative stress defense genes and for mitochondrial maintenance. Consistent with chronic oxidative stress, mitochondria had an elongated and enlarged ultrastructure. Livers also had distinctive, cystic lesions. Depending on the endpoint, effects of γ-rays in the same dose range were either lesser or not detected. Results provide a quantitative and qualitative framework for understanding relative contributions of HZE particle radiation exposure and aging to chronic oxidative stress and tissue degeneration

  18. Development of A Mouse Model of Menopausal Ovarian Cancer

    Directory of Open Access Journals (Sweden)

    Elizabeth R. Smith

    2014-02-01

    Full Text Available Despite significant understanding of the genetic mutations involved in ovarian epithelial cancer and advances in genomic approaches for expression and mutation profiling of tumor tissues, several key questions in ovarian cancer biology remain enigmatic: the mechanism for the well-established impact of reproductive factors on ovarian cancer risk remains obscure; questions of the cell of origin of ovarian cancer continue to be debated; and the precursor lesion, sequence, or events in progression remain to be defined. Suitable mouse models should complement the analysis of human tumor tissues and may provide clues to these questions currently perplexing ovarian cancer biology.A potentially useful model is the germ cell-deficient Wv (white spotting variant mutant mouse line, which may be used to study the impact of menopausal physiology on the increased risk of ovarian cancer. The Wv mice harbor a point mutation in c-Kit that reduces the receptor tyrosine kinase activity to about 1-5% (it is not a null mutation. Homozygous Wv mutant females have a reduced ovarian germ cell reservoir at birth and the follicles are rapidly depleted upon reaching reproductive maturity, but other biological phenotypes are minimal and the mice have a normal life span. The loss of ovarian function precipitates changes in hormonal and metabolic activity that model features of menopause in humans. As a consequence of follicle depletion, the Wv ovaries develop ovarian tubular adenomas, a benign epithelial tumor corresponding to surface epithelial invaginations and papillomatosis that mark human ovarian aging. Ongoing work will test the possibility of converting the benign epithelial tubular adenomas into neoplastic tumors by addition of an oncogenic mutation, such as of Tp53, to model the genotype and biology of serous ovarian cancer.Model based on the Wv mice may have the potential to gain biological and etiological insights into ovarian cancer development and prevention.

  19. Diagnosis and Management of Ovarian Cancer.

    Science.gov (United States)

    Doubeni, Chyke A; Doubeni, Anna R; Myers, Allison E

    2016-06-01

    Ovarian cancer is the most lethal gynecologic cancer. Less than one-half of patients survive for more than five years after diagnosis. Ovarian cancer affects women of all ages but is most commonly diagnosed after menopause. More than 75% of affected women are diagnosed at an advanced stage because early-stage disease is usually asymptomatic and symptoms of late-stage disease are nonspecific. The strongest risk factors are advancing age and family history of ovarian and breast cancer. Women who have symptoms concerning for ovarian cancer should undergo a physical examination, transvaginal ultrasonography, and measurement of biomarkers such as cancer antigen 125. If results are suspicious for ovarian cancer, the patient should be referred to a gynecologic oncologist. Despite the low rate of early diagnosis, guidelines recommend against routine screening for ovarian cancer in average-risk women because screening, including routine pelvic examinations, is ineffective and associated with harm. However, a recent trial found a potential benefit of annual screening using an algorithm based on serial cancer antigen 125 measurements followed by transvaginal ultrasonography for women at increased risk, as determined by the algorithm. Women with an increased-risk family history should be referred for genetic counseling and, if genetic mutations (e.g., BRCA mutations) are identified, bilateral salpingo-oophorectomy can be considered for risk reduction. In both average- and high-risk women, long-term hormonal contraceptive use reduces risk by about 50%. The treatment of ovarian cancer usually involves surgery, with or without intraperitoneal and intravenous chemotherapy. Primary care physicians have important roles in posttreatment surveillance and end-of-life care. PMID:27281838

  20. The WAIS Divide deep ice core WD2014 chronology – Part 2: Annual-layer counting (0–31 ka BP

    Directory of Open Access Journals (Sweden)

    M. Sigl

    2015-07-01

    Full Text Available We present the WD2014 chronology for the upper part (0–2850 m, 31.2 ka BP of the West Antarctic Ice Sheet (WAIS Divide ice core. The chronology is based on counting of annual layers observed in the chemical, dust and electrical conductivity records. These layers are caused by seasonal changes in the source, transport, and deposition of aerosols. The measurements were interpreted manually and with the aid of two automated methods. We validated the chronology by comparing to two high-accuracy, absolutely dated chronologies. For the Holocene, the cosmogenic isotope records of 10Be from WAIS Divide and 14C for Intcal13 demonstrated WD2014 was consistently accurate to better than 0.5 % of the age. For the glacial period, comparisons to the Hulu Cave chronology demonstrated WD2014 had an accuracy of better than 1 % of the age at three abrupt climate change events between 27 and 31 ka. WD2014 has consistently younger ages than Greenland ice-core chronologies during most of the Holocene. For the Younger Dryas-Preboreal transition (11 546 ka BP, 24 years younger and the Bølling-Allerød Warming (14 576 ka, 7 years younger WD2014 ages are within the combined uncertainties of the timescales. Given its high accuracy, WD2014 can become a reference chronology for the Southern Hemisphere, with synchronization to other chronologies feasible using high quality proxies of volcanism, solar activity, atmospheric mineral dust, and atmospheric methane concentrations.

  1. Bilateral ovarian mixed epithelial adenocarcinoma in a postmenopausal woman with unilateral ovarian yolk sac tumor component.

    Science.gov (United States)

    Chen, Qin; Chen, Xiaoduan

    2014-01-01

    Ovarian yolk sac tumors (YSTs) usually occur in the young women and have been rarely documented in perimenopausal and postmenopausal women. The different age distribution supposes their complex nomenclature and histogenesis. We report a case of bilateral ovarian epithelial carcinoma with right ovarian YST component in a postmenopausal woman. The patient was treated by surgery and adjuvant combination chemotherapy of taxol and carboplatin for 6 courses and has been clinically free of tumor for 6 months. The correlation between the YST and the epithelial components always confuse us. Ovarian yolk sac tumors are not a discrete entity and represent a multifaceted group of neoplasms. The conjunction of multi antibodies help in differential diagnoses. In addition to a thorough case description, the literature concerning this entity is reviewed and discussed. PMID:25550883

  2. MALIGNANT OVARIAN PATHOLOGY FOR THE WOMAN OVER 60

    Directory of Open Access Journals (Sweden)

    Eduarg Crauciuc

    2013-03-01

    Full Text Available The present study refers to the incidence of malignant ovarian pathology among the patients over 60, and italso refers to the clinical-evolutionary and therapeutic specific features of the neoplastic disease at this age. The clinical picturein ovarian cancer is totally unspecific and it is usually discovered by mistake, following the procedure of ablation of anapparently benign ovarian tumour, as an “intraoperative surprise”. We performed a retrospective case –control study thatmonitored the epidemiological, histological, clinical-evolutionary and therapeutic characteristics of ovarian neoplasias for106 patients over 60, from a total of 578 patients with ovarian pathology that were hospitalized in the Clinic ofObstetrics-Gynaecology from „Elena Doamna” Hospital Iaşi during 2008-2012. The incidence of ovarian tumourpathology increases in a progressive way depending on age, and it hits really high values after 60 (39.6%. If the familyhistory includes ovarian/endometrial/breast/colon cancer, for women over 60, this theoretically increases the risk ofgetting ovarian neoplasia 3 times (RR=2.97. Ovarian tumours can appear from any cell that is part of an ovarian tissue orfrom other cells that precede them. Hence the big number of histological types (68 types of ovarian tumours. Whenspeaking from the anatomo-pathologic point of view, the papillary cystadenocarcinoma was identified in over half of thepatients who had surgery (52.4%. The analysis of this data shows that the gynaecologist’s attention should be focusedmainly on diagnosing the gynaecologic neoplasia in early stages, as genital oncologic screening also has a very importantrole in prolonging the life of these patients.

  3. IceChrono1: a probabilistic model to compute a common and optimal chronology for several ice cores

    OpenAIRE

    F. Parrenin; Bazin, L.; E. Capron; Landais, A.; B. Lemieux-Dudon; Masson-Delmotte, V.

    2015-01-01

    Polar ice cores provide exceptional archives of past environmental conditions. The dating of ice cores and the estimation of the age-scale uncertainty are essential to interpret the climate and environmental records that they contain. It is, however, a complex problem which involves different methods. Here, we present IceChrono1, a new probabilistic model integrating various sources of chronological information to produce a common and optimized chronology for several ice cor...

  4. The absolute chronology and thermal processing of solids in the solar protoplanetary disk

    DEFF Research Database (Denmark)

    Connelly, James Norman; Bizzarro, Martin; Krot, Alexander N.;

    2012-01-01

    Transient heating events that formed calcium-aluminum - rich inclusions (CAIs) and chondrules are fundamental processes in the evolution of the solar protoplanetary disk, but their chronology is not understood. Using U-corrected Pb-Pb dating, we determined absolute ages of individual CAIs...

  5. Ectopic ovarian pregnancy

    International Nuclear Information System (INIS)

    A case of ectopic ovarian pregnancy is presented occurring in a 24 years old woman after natural conception. The clinical diagnosis was ruptured tubal pregnancy. Gross findings were suggestive of ruptured corpus luteum cyst on exploration. The histopathological examination of specimen brought forward the diagnosis of ovarian pregnancy. (author)

  6. Clarifying Some Fundamental Errors in Herries' “A Chronological Perspective on the Acheulian and Its Transition to the Middle Stone Age in Southern Africa: The Question of the Fauresmith” (2011

    Directory of Open Access Journals (Sweden)

    Lawrence Barham

    2012-01-01

    Full Text Available Herries provides a timely review of the archaeological and dating evidence of the transition from the Acheulean to the Middle Stone Age (MSA in southern Africa, however, in relation to the site of Twin Rivers, Zambia he makes several fundamental errors of interpretation that demand correction. The stratigraphic sequence of the site is admittedly complex, but it deserves a more careful analysis than that offered by Herries. This detailed response by the most recent excavator of the site addresses Herries critique by placing the site in its historical context and then dealing with the central issue of the association of dated speleothem with the surviving archaeological deposits. Herries is shown to have mistakenly combined the dates from two separate cave passages and to have misunderstood the published sections, plans, and taphonomic assessment of each excavation area. His reinterpretation of the site as being significantly younger than published is based on a conflation of unrelated data.

  7. Ovarian failure due to cancer treatment and fertility preservation options

    Directory of Open Access Journals (Sweden)

    Soheila Aminimoghaddam

    2016-04-01

    Full Text Available Primary ovarian insufficiency (POI, commonly referred to premature ovarian failure, is defined as ovarian failure before the age of 40 years. It is the loss of ovarian function caused by a process directly affecting ovaries. Cancer therapy which includes surgery, radiotherapy, and chemotherapy influence ovarian function, leading to premature menopause and loss of fertility. POI is idiopathic in most cases (74-90%. The known causes, in addition to anticancer treatment, are other processes like chromosomal abnormalities, autoimmunity, and natural aging can result in secondary ovarian failure, which is detected by an increase in serum gonadotropin levels (FSH and LH. There are evident risks of POI in women treated for cancer. Those who receive anticancer treatments have an increased risk of developing POI. There by, anticancer drugs and radiation therapy are considered as the most common toxins of ovaries. Although cancer incidence rates in women less than 50 years old continue to increase during recent years, mortality rates are dramatically decreasing due to modern advances in treatment. Increasing numbers of survivors are now confronted with the long-term consequences of exposure to these treatments. The pool of primordial follicles in the ovary is fixed and any injury to the ovary can potentially reduce this ovarian reserve, effectively advancing the patient’s reproductive age, thus narrowing the window of reproductive opportunity. Ovarian failure occurs in a significant percentage of childhood cancer survivors and many of them will seek care for reproductive dysfunction. Nevertheless, Embryo cryopreservation, oocyte cryopreservation, ovary tissue cryopreservation, ovarian suppression and oophoro-pexy are some options to preserve fertility in these groups. As a result, having foreknowledge of potential treatment related ovarian failure will allow the physician to give a better counsel to patients and their family regarding the importance and

  8. The IVF Outcome Counseling Based on the Model Combining DHEAS and Age in Patients with Low AMH Prior to the First Cycle of GnRH Antagonist Protocol of Ovarian Stimulation

    Directory of Open Access Journals (Sweden)

    Miro Šimun Alebić

    2013-01-01

    Full Text Available Objective. To investigate the endocrine and/or clinical characteristics of women with low anti-Müllerian hormone (AMH that could improve the accuracy of IVF outcome prediction based on the female age alone prior to the first GnRH antagonist IVF cycle. Methods. Medical records of 129 patients with low AMH level (<6.5 pmol/L who underwent their first GnRH antagonist ovarian stimulation protocol for IVF/ICSI were retrospectively analyzed. The main outcome measure was the area under the ROC curve (AUC-ROC for the models combining age and other potential predictive factors for the clinical pregnancy. Results. Clinical pregnancy rate (CPR per initiated cycles was 11.6%. For the prediction of clinical pregnancy, DHEAS and age showed AUC-ROC of 0.726 (95%CI 0.641–0.801 and 0.662 (95%CI 0.573–0.743, respectively (. The predictive accuracy of the model combining age and DHEAS (AUC-ROC 0.796; 95%CI 0.716–0.862 was significantly higher compared to that of age alone (. In patients <37.5 years with DHEAS  pmol/L, 60% (9/15 of all pregnancies were achieved with CPR of 37.5%. Conclusions. DHEAS appears to be predictive for clinical pregnancy in younger women (<37.5 years with low AMH after the first GnRH antagonist IVF cycle. Therefore, DHEAS-age model could refine the pretreatment counseling on pregnancy prospects following IVF.

  9. Progress in the Early Solar System Chronology: A Sketch of an Ever-Changing Landscape

    Science.gov (United States)

    Amelin, Yuri; Yin, Q.-Z.; Krot, A. N.; Bouvier, A.; Wadhwa, M.; Kleine, T.; Nyquist, L. E.

    2011-01-01

    The years since the Workshop on the Chronology of Meteorites and the Early Solar System, are marked with ongoing progress in cosmochronology. Rapid improvements in techniques, discovery of new meteorites unlike any previously known, and findings that what was deemed well established constants are actually variables, will be reflected in an updated review of the solar system chronology we are currently preparing. Along with updating the database of meteorite ages, it will involve development of a set of criteria for evaluation of accuracy and consistency of isotopic dates across the entire range of meteorite classes and isotope chronometer systems. Here we present some ideas on what we think is important in meteorite chronology, and invite the cosmochemistry community to discuss them.

  10. Chemotherapy of ovarian cancer in elderly patients

    Institute of Scientific and Technical Information of China (English)

    Tiffany A. Troso-Sandoval; Stuart M. Lichtman

    2015-01-01

    Epithelial ovarian cancer is primarily a disease of older women. Advanced age is risk factor for decreased survival. Optimal surgery and the safe and effective administration of chemotherapy are essential for prolonged progression-free and overall survival (OS). In this article, the available regimens in both the primary treatment and relapsed setting are reviewed.

  11. Laparoscopic Ovarian Surgery in Children and Adolescents

    OpenAIRE

    Kim, Hong-Bae; Cho, Hye-Yon; Park, Sung-Ho; Park, Sung-Taek

    2015-01-01

    Background and Objectives: Although laparoscopy is widely used in gynecologic surgery in adults, few studies have been undertaken to examine its use in young and adolescent patients. This study was conducted to investigate the safety and feasibility of laparoscopic surgery for the treatment of benign ovarian disease in children and adolescents. Methods: A retrospective chart review was conducted on 106 patients (age,

  12. Management of Ovarian Cancer in Elderly.

    Science.gov (United States)

    Giri, Sushil K; Nayak, Bhagyalaxmi

    2015-01-01

    As a result of increasing life expectancy, the cancer incidence in older population is on the rise. Ovarian cancer (OC) is predominantly the disease of elderly women. More than half of all OC occur in women older than 65 years. The incidence of the disease increases with the advancing age, peaking during 7(th) decade of life and remains elevated until the age of 80 years. With the changing demographic scenario the percentage of elderly patients is increasing and gynaecologic oncologists need to focus more on these patients and their specific needs. Due to their higher risk of morbidity and mortality compared to younger patients, elderly patients with advanced ovarian cancer are challenging to treat and are often treated less radically. Their outcome is impaired despite no consistent prognostic effect of age itself. To offer optimal radical management of the elderly women with ovarian cancer and to avoid suboptimal treatment, biological age and functional status need to be considered before individualized treatment plans are defined. Pretreatment assessment can be achieved by using different assessment tools. Patients can tolerate surgery and chemotherapy, as long as they are individually assessed for their medical, psychological, and functional capabilities before therapeutic intervention is initiated. Prospective trials involving elderly women with ovarian cancer are the need of the day to offer justified evidenced based optimal treatment for those who will be benefited from the treatment. PMID:26411955

  13. When erosion ruins the chronology

    Science.gov (United States)

    Wolters, Steffen; Enters, Dirk; Blume, Katharina; Lücke, Andreas

    2016-04-01

    Human land-use has considerably shaped the landscape of north-western Germany over the past millennia. Deforestation and agriculture created a predominantly open scenery preserved until today with only a few remnants of former landscape elements such as woodlands, peat bogs, heath lands and lakes. Here we present a multi-proxy approach including sedimentological and geochemical parameters (e. g. element concentrations and stable isotopes) as well as biological proxies (pollen, macro fossils and diatoms) combined with an archaeological site analysis to investigate the effects of prehistoric land-use on lake systems and their catchment areas with a special focus on changes of the water quality, e. g. eutrophication and acidification and its natural regeneration during phases of weaker land-use impact. The study reveals a millenia-long history of erosion processes caused by successive selective woodland clearances starting in Neolithic Times. The geochemical evidence of soil erosion is recorded by distinct peaks of the terrigenic elements K and Ti. However, due to (1) the low sensitivy of the XRF scanner for Si and (2) the prevalence of diatom related biogenic silicon XRF-scanning of highly organic lake sediments fails to reflect the actual sand input caused by erosion. Particularly single quartz grains are not detected in the organic sediment matrix. Therefore we make successful use of mineral grain analysis which previously has only been applied to record aeolian input in bogs. K and Ti concentrations are not correlated with the content of mineral grains which suggest two different erosion processes. Our efforts to construct robust age-depth relationships based on AMS 14C-dates of terrestrial plant macrofossils reveal a specific dating issue of northwest German lakes. Especially in younger sediments we observe 14C-dates which are on the one hand too old and on the other hand among themselves roughly contemporaneous. We explain this feature with the extensive bog

  14. Chronology violation and the Cosmological Argument

    CERN Document Server

    Romero, G E

    2003-01-01

    The Kalam Cosmological Argument is perhaps the most solid and widly discussed argument for a caused creation of the universe. The usual objections to the argument mainly focus on the second premise. In this paper we discuss the dependency of the first premise on the topological structure of the space-time manifold adopted for the underlying cosmological model. It is shown that in chronology-violating space-times the first premise is also violated. The chronology-violation, in turn, requires a massive violation of the so-called energy conditions which could have observational effects that are briefly discussed here. Hence, astronomical observations could be relevant for the validity of the metaphysical argument. In this sense, it is possible to talk of "observational theology".

  15. A chronology of librarianship, 1960-2000

    CERN Document Server

    Wilhite, Jeffrey M

    2009-01-01

    This book covers all areas of library literature that inform the history of librarianship and ranges over multiple continents. Its broad scope lends itself to wide use by scholars and students of library history and library literature. The chronology is presented in a dictionary format and separated into decades. It is complemented by a comprehensive bibliography and both subject and name indexes, which are cross-listed for ease of use.

  16. A new ovarian response prediction index (ORPI: implications for individualised controlled ovarian stimulation

    Directory of Open Access Journals (Sweden)

    Oliveira Joao Batista A

    2012-11-01

    Full Text Available Abstract Background The objective was to present a new ovarian response prediction index (ORPI, which was based on anti-Müllerian hormone (AMH levels, antral follicle count (AFC and age, and to verify whether it could be a reliable predictor of the ovarian stimulation response. Methods A total of 101 patients enrolled in the ICSI programme were included. The ORPI values were calculated by multiplying the AMH level (ng/ml by the number of antral follicles (2–9 mm, and the result was divided by the age (years of the patient (ORPI=(AMH x AFC/Patient age. Results The regression analysis demonstrated significant (PP=0.006 and collecting greater than or equal to 4 oocytes (OR: 49.25; PPP Conclusions The ORPI exhibited an excellent ability to predict a low ovarian response and a good ability to predict a collection of greater than or equal to 4 MII oocytes, an excessive ovarian response and the occurrence of pregnancy in infertile women. The ORPI might be used to improve the cost-benefit ratio of ovarian stimulation regimens by guiding the selection of medications and by modulating the doses and regimens according to the actual needs of the patients.

  17. Unusual presentation of twisted ovarian cyst

    Directory of Open Access Journals (Sweden)

    Vineet V Mishra

    2016-01-01

    Full Text Available Ovarian torsion (also termed as adnexal torsion refers to partial or complete rotation of the ovary and a portion of fallopian tube along its supplying vascular pedicle. It occurs commonly in reproductive age group; more on the right side (60% and often presents with acute lower abdominal pain lasting for few hours and up to 24 h, accounting for 2.7% of acute gynecological conditions. It is one of the devastating conditions, hampering blood supply of ovary which may lead to total necrosis of ovarian tissue and complications, if not diagnosed and managed in time. Hence, we present a case on a twisted ovarian cyst in postmenopausal woman with unusual symptomatology leading to delayed diagnosis and loss of an ovary.

  18. Gonadotropin-releasing hormone agonists cotreatment during chemotherapy in borderline ovarian tumor and ovarian cancer patients

    Institute of Scientific and Technical Information of China (English)

    ZHU Hong-lan; WANG Yan; LI Xiao-ping; WANG Chao-hua; WANG Yue; CUI Heng; WANG Jian-liu

    2013-01-01

    Background Recently,conservative surgery is acceptable in young patients with borderline ovarian tumor and ovarian cancer.The preservation of these patients' future fertility has been the focus of recent interest.This study aimed to observe the effect of gonadotropin-releasing hormone agonists (GnRHa) cotreatment during chemotherapy in borderline ovarian tumor and ovarian cancer patients.Methods Sixteen patients who were treated with fertility preservation surgery for borderline ovarian tumor and ovarian cancer and then administered GnRHa during chemotherapy in Peking University People's Hospital from January 2006 to July 2010 were retrospectively analyzed.This group was compared with a control group of 16 women who were treated concurrently with similar chemotherapy (n=5) without GnRHa or were historical controls (n=11).The disease recurrence,the menstruation status and reproductive outcome were followed up and compared between the two groups.Results There were no significant differences between both groups regarding age,body weight,height,marriage status,classification of the tumors,stage of the disease,as were the cumulative doses of each chemotherapeutic agent.One (1/16) patient in the study group while 2 (2/16) patients in the control group relapsed 2 years after conclusion of the primary treatment (P >0.05).All of the 16 women in the study group compared with 11 of the 16 patients in the control group resumed normal menses 6 months after the termination of the treatment (P <0.05).There were 4 spontaneous pregnancies in the study group while 2 in the control group,all of the neonates were healthy.Conclusions GnRHa administration before and during chemotherapy in borderline ovarian tumor and ovarian cancer patients who had undergone fertility preservation operation may bring up higher rates of spontaneous resumption of menses and a better pregnancy rate.Long-term follow up and large scale clinical studies are required.

  19. Ovarian reserve tests

    Directory of Open Access Journals (Sweden)

    Padma Rekha Jirge

    2011-01-01

    Full Text Available Ovarian reserve plays a crucial role in achieving pregnancy following any treatment in subfertile women. The estimation of ovarian reserve is routinely performed through various ovarian reserve tests (ORTs in an effort to predict the response and outcome in couples prior to In Vitro Fertilization and counsel them. Most widely used tests are basal follicle stimulating hormone and anti-Mullerian hormone and antral follicle count. The role of ORTs in our routine practice is discussed in this article. A MEDLINE search was done to identify suitable articles for review.

  20. Ovarian endometriomas and IVF: a retrospective case-control study

    Directory of Open Access Journals (Sweden)

    Guidetti Daniela

    2011-06-01

    Full Text Available Abstract We performed this retrospective case-control study analyzing 428 first-attempt in vitro fertilization (IVF cycles, among which 254 involved women with a previous or present diagnosis of ovarian endometriosis. First, the results of these 254 cycles were compared with 174 cycles involving patients with proven non-endometriotic tubal infertility having similar age and body mass index. Women with ovarian endometriosis had a significantly higher cancellation rate, but similar pregnancy, implantation and delivery rates as patients with tubal infertility. Second, among the women with ovarian endometriosis, the women with a history of laparoscopic surgery for ovarian endometriomas prior to IVF and no visual endometriosis at ovum pick-up (n = 112 were compared with the non-operated women and visual endometriomas at ovum pick-up (n = 142. Patients who underwent ovarian surgery before IVF had significantly shorter period, lower antral follicle count and required higher gonadotropin doses than patients with non-operated endometriomas. The two groups of women with a previous or present ovarian endometriosis did, however, have similar pregnancy, implantation and live birth rates. In conclusion, ovarian endometriosis does not reduce IVF outcome compared with tubal factor. Furthermore, laparoscopic removal of endometriomas does not improve IVF results, but may cause a decrease of ovarian responsiveness to gonadotropins.

  1. Ovarian stimulation in patients with breast cancer.

    Science.gov (United States)

    Muñoz, Elkin; González, Naira; Muñoz, Luis; Aguilar, Jesús; Velasco, Juan A García

    2015-01-01

    Breast cancer is the most prevalent malignancy among women under 50. Improvements in diagnosis and treatment have yielded an important decrease in mortality in the last 20 years. In many cases, chemotherapy and radiotherapy develop side effects on the reproductive function. Therefore, before the anti-cancer treatment impairs fertility, clinicians should offer some techniques for fertility preservation for women planning motherhood in the future. In order to obtain more available oocytes for IVF, the ovary must be stimulated. New protocols which prevent exposure to increased estrogen during gonadotropin stimulation, measurements to avoid the delay in starting anti-cancer treatment or the outcome of ovarian stimulation have been addressed in this review. There is no evidence of association between ovarian stimulation and breast cancer. It seems that there are more relevant other confluent factors than ovarian stimulation. Factors that can modify the risk of breast cancer include: parity, age at full-term birth, age of menarche, and family history. There is an association between breast cancer and exogenous estrogen. Therefore, specific protocols to stimulate patients with breast cancer include anti-estrogen agents such as letrozole. By using letrozole plus recombinant follicular stimulating hormone, patients develop a multifollicular growth with only a mild increase in estradiol serum levels. Controlled ovarian stimulation (COS) takes around 10 days, and we discuss new strategies to start COS as soon as possible. Protocols starting during the luteal phase or after inducing the menses currently prevent a delay in starting ovarian stimulation. Patients with breast cancer have a poorer response to COS compared with patients without cancer who are stimulated with conventional protocols of gonadotropins. Although many centres offer fertility preservation and many patients undergo ovarian stimulation, there are not enough studies to evaluate the recurrence, breast cancer

  2. 40岁以下妇女卵巢上皮癌62例临床分析%Clinical analysis of 62 women with epithelial ovarian cancer under age of 40 years

    Institute of Scientific and Technical Information of China (English)

    唐莉; 叶旭彬; 吴雪薇

    2014-01-01

    Objective To investigate the clinical characteristics, treatment, survival rate and prognosis factors of the young women with epithelial ovarian cancer. Methods Clinical data of 62 women with epithelial ovarian cancer under the age of 40 years treated in our hospital from January 1990 to December 2012 were analyzed retrospectively. The survival rate was calculated using the life table.The cox model was used to analyze and compare the factors influencing prognosis. Results Sixty-two patients diagnosed with epithelial ovarian cancer had a median age of (31.3±1.6) years. Physical examination found abdominal mass in 17 patients and stomachache and abdominal distension in 12 patients respectively.The average maximum radial line of lump was (13.15±2.17) cm.Fifty-seven patients could receive satisfaction cytoreductive surgery.Thirty-seven patients were in surgical pathological stage I,accounting for 59.67%,7 patients stage Ⅱ,accounting for 11.29%,13 patients stage Ⅲ,accounting for 20.96%,and 5 patients stage IV,accounting for 8.06%. Pathological differentiation degrees were mainly serous adenocarcinoma (35 patients,56.45%) and mucinous adenocarcinoma(18 patients,29.03%).In terms of pathological differentiation degree,38 patients(61.2%) were highly differentiated,15 patient (24.2%) were moderately differentiated and 9 patients (14.5%) were poorly differentiated.Fifty-nine patients received preoperative and postoperative chemotherapy based on platinum or taxanes.Of the 12 patients receiving conservative surgery(all patients were Ia and G1),10 patients survived without tumor(83.34%).The 3-year survival rate calculated based on the life table method was 86.7%and the 5-year survival rate was 78.3%. Conclusion For the women with epithelial ovarian cancer under the age of 40 years,the size of tumor is large,unilateral is mostly seen, surgical pathological staging is early, pathological differentiation degree is good,serous cystadenocarcinoma is mostly seen,the total 5-year

  3. Ovarian Cancer Stage I

    Science.gov (United States)

    ... An inset shows cancer cells in the pelvic peritoneum. Also shown are the fallopian tubes, uterus, cervix, ... c) cancer cells are found in the pelvic peritoneum. Topics/Categories: Anatomy -- Gynecologic Cancer Types -- Ovarian Cancer ...

  4. Frost-ring chronologies as dendroclimatic proxies of boreal environments

    Science.gov (United States)

    Payette, Serge; Delwaide, Ann; Simard, Martin

    2010-01-01

    Frost rings are formed in tree stems when growing-season frosts affect immature wood cells, producing collapsed cells within annual tree rings. Open boreal forests are most susceptible to record growing-season frost because they lack the greenhouse effect commonly observed in closed forests. Here we present a novel method to construct regional frost-ring chronologies in lichen-black spruce woodlands of the boreal forest zone. Because the ability of trees to form frost rings depends on several factors (including bark thickness and ring width), we used two models to produce a Frost Composite Index based on a frost susceptibility window of cambial age growing-season frost activity may be used as dendroclimatic proxies of climate variability and may give insights into future risks of frost damage in a warming climate.

  5. Isotope chronological trace of granite gravel in Hefei Basin

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The discovery of granite gravel in Hefei Jurassic backland basin, which came from the Dabie Shah or North Huaiyang, has a great significance for probing into uplift and exhumation of the Dabie orogenic belt. Lithochemical and isotope chronological analyses on the granite gravel in the Sanjianpu Formation and the Fenghuangtai Formation in Jinzhai County prove that post-orogenic granite was developed in the major provenance of the Hefei Basin; that is, Dabie Shah or North Huaiyang. Discordant lower intersection point age of zircon U-Pb of granite gravel is 40Ar/39about 214 Ma, and Ar/39Ar age of muscovite about 196 Ma,K-Ar age of K-spar about 181 Ma. The former is the diagenetic age of the sample, and the latter two represent the sealed ages of muscovite and K-spar respectively. The age of sedimentary rocks in which a lot of granite gravels appear in the sedimentary section may represent the newest age of the exhumation of the granite body, so we assume that the age is 166 Ma. Therefore, we calculated the uplift rates of the granite body from Late Triassic to early Middle Jurassic; that is about 0.08 km/Ma and 0.4-0.3 km/Ma in the early slowly uplifting stage and later fast uplifting stage respectively, after the formation of the body at 214 Ma. These results are basically identical to the uplifting ages of the Dabie ultrahigh pressure metamorphic (UHPM) belt and the North Huaiyang thrust belt.

  6. Epidemiology of ovarian malignancies

    Directory of Open Access Journals (Sweden)

    Akanksha Sood

    2016-01-01

    Conclusions: The epidemiology and presentation of ovarian tumours has remained unchanged since last 3 decades. Nulliparity is not as significant a factor in the aetiology of ovarian malignancy however contraception leading to anovulatory cycles (OC pills may have a protective role. Infertility can be suggested as a risk factor but the treatment for infertility and its role in oncogenesis remains controversial. [Int J Reprod Contracept Obstet Gynecol 2016; 5(1.000: 186-193

  7. Childhood Ovarian Malignancy

    OpenAIRE

    Mahadik, Kalpana; Ghorpade, Kanchanmala

    2014-01-01

    Objective of this article is to appraise diagnostic aspects and treatment modalities in childhood ovarian tumor in background of available evidence. Literature search on Pubmed revealed various aspects of epidemiology, histopathological diagnosis, and treatment of pediatric ovarian tumor. 85 % of childhood tumors are germ cell tumors. The varied histopathological picture in germ cell tumors poses a diagnostic and therapeutic challenge. Immunohistochemistry and newer genetic markers like SALL4...

  8. Pathobiology of ovarian carcinomas

    OpenAIRE

    Mojgan Devouassoux-Shisheboran; Catherine Genestie

    2015-01-01

    Ovarian tumors comprise a heterogeneous group of lesions, displaying distinct tumor pathology and oncogenic potentiel. These tumors are subdivided into three main categories: epithelial, germ cell, and sex-cord stromal tumors. We report herein the newly described molecular abnormalities in epithelial ovarian cancers (carcinomas). Immunohistochemistry and molecular testing help pathologists to decipher the significant heterogeneity of this disease. Our better understanding of the molecular bas...

  9. Transvaginal ultrasound ovarian diathermy: sheep as an experimental model

    Directory of Open Access Journals (Sweden)

    Pimentel Anita M

    2012-01-01

    Full Text Available Abstract Background Some techniques of transvaginal ovarian drilling have been previously described. Nevertheless a monopolar transvaginal ovarian cauterization, that use the expertise and safety of transvaginal puncture for oocyte captation seems to be an easier and feasible approach. The aim of this study was to develop a minimally invasive ovarian cauterization technique under transvaginal ultrasound control, and to evaluate the safety of the transvaginal ovarian monopolar cauterization, female sheep at reproductive age were used as an experimental model. Findings An experimental study was performed in a university research center. Seventeen female sheep (15 Corriedale e 2 Suffolk in reproductive age were submitted to transvaginal ovarian cauterization with a monopolar Valleylab Force 2 electrocautery. Macroscopic and microscopic lesions were assessed. Ovarian size were 1.31 cm2 ± 0,43 (Corriedale and 3.41 cm2 ± 0,64 (Suffolk. From 30 ovaries from Corriedale sheep punctured, only 3 were cauterized, presenting macroscopic and typical microscopic lesion. In the Suffolk sheep group, only one ovary was cauterized. No lesion could be found in the needle path. Conclusions This is the first experimental animal model described for ovarian cauterization needle guided by transvaginal ultrasound. The sheep does not seem to be the ideal animal model to study this technique. Another animal model, whose ovaries are better identified by transvaginal ultrasound should be sought for this technique, theoretically less invasive, before it could be offered safely to women with polycystic ovary syndrome.

  10. Miscarriage risk for IVF pregnancies in poor responders to ovarian hyperstimulation

    NARCIS (Netherlands)

    Haadsma, Maaike L.; Groen, Henk; Mooij, Thea M.; Burger, Curt W.; Broekmans, Frank J. M.; Lambalk, Cornelis B.; van Leeuwen, Flora E.; Hoek, Annemiek

    2010-01-01

    The increasing miscarriage rate with advancing female age is attributed to a decline in oocyte quality. A poor response to ovarian hyperstimulation is often an expression of a decrease in oocyte quantity. Although oocyte quality and quantity both decrease as a result of ovarian ageing, it is unclear

  11. Miscarriage risk for IVF pregnancies in poor responders to ovarian hyperstimulation.

    NARCIS (Netherlands)

    Haadsma, M.L.; Groen, H.; Mooij, T.M.; Burger, C.W.; Broekmans, F.J.; Lambalk, C.B.; Leeuwen, F.E. van; Hoek, A.

    2010-01-01

    The increasing miscarriage rate with advancing female age is attributed to a decline in oocyte quality. A poor response to ovarian hyperstimulation is often an expression of a decrease in oocyte quantity. Although oocyte quality and quantity both decrease as a result of ovarian ageing, it is unclear

  12. Trends in incidence of borderline ovarian tumors in Denmark 1978-2006

    DEFF Research Database (Denmark)

    Hannibal, Charlotte Gerd; Huusom, Lene Drasbek; Kjaerbye-Thygesen, Anette;

    2011-01-01

    To examine period-, age- and histology-specific trends in the incidence rate of borderline ovarian tumors in Denmark in 1978-2006.......To examine period-, age- and histology-specific trends in the incidence rate of borderline ovarian tumors in Denmark in 1978-2006....

  13. Topical versus Chronological Organization of Lifespan Development: Does It Make a Difference in Student Retention and Understanding?

    Science.gov (United States)

    Spangler, Brooke R.; Kiel, Elizabeth J.

    2015-01-01

    This study aimed to determine whether taking a chronological approach (CA) or topical approach (TA) to teaching developmental psychology resulted in different learning outcomes. Across two semesters, in four classes, 354 students participated (M[subscript age] = 19.76, SD[subscript age] = 2.93 years), 66% identifying as female. One instructor…

  14. It's Never over until It's over: How Can Age and Ovarian Reserve Be Mathematically Bound through the Measurement of Serum AMH-A Study of 5069 Romanian Women.

    Directory of Open Access Journals (Sweden)

    Bogdan Doroftei

    Full Text Available Wide regional differences in the age-related Anti Mullerian hormone (AMH regression patterns or age at onset of natural menopause have been reported, possibly reflecting genetic, socioeconomic, environmental, racial or ethnic peculiarities. Moreover, adaptation of AMH levels from different assays using regression functions may lack accuracy and externally defined references for AMH levels may not fully comply with a specific geographical area. The current study aimed to establish an accurate mathematical relationship between AMH serum values and age in a large group of women from Romania, as any consistent difference from previously reported regression models may aid in building specific profiles for the AMH decline with age in this geographical region. Our study pointed out to the quadratic regression as the most fitted pattern of correlation for all the age groups between 24 and 45. To our knowledge the current manuscript is based on the singular study carried out in this geographical region, generating a particular age-related pattern of association between age and serum AMH levels in women, regardless of their subjacent pathologies.

  15. Valproate, bipolar disorder and polycystic ovarian syndrome

    Directory of Open Access Journals (Sweden)

    Okanović Milana

    2016-01-01

    Full Text Available Introduction. Polycystic ovarian syndrome is a syndrome of ovarian dysfunction with the principal features of hyperandrogenism and polycystic ovary morphology. A large number of studies conducted on this topic have suggested a possible role of anticonvulsants, particularly valproate, in the pathogenesis or risk factors associated with polycystic ovarian syndrome. Bipolar treatment guidelines from Canada and the United States of America recommend valproate as the first line strategy in the acute treatment of bipolar disorder. Discussion. Most persons with bipolar disorder require maintenance treatment. Long-term administration of valproate in women with bipolar disorder or epilepsy is believed to result in the increased risk of hyperandro­genism, menstrual abnormalities and polycystic ovaries. Valproate may also increase the risk of infertility and other associated symptoms of polycystic ovarian syndrome. Therefore, particular caution is indicated in the use of valproate in women of reproductive age. Conclusion. The treatment of the female patients with bipolar disorder presents various challenges for the clinician. Every woman of reproductive age needs to know the risk and benefits of her pharmacologic treatment options. Bipolar disorder should be considered chronic disorder, whose development is largely affected by hormonal changes and reproductive cycle in women. These issues should be researched more thoroughly in order to opt for the most appropriate treatment in women with bipolar disorder.

  16. Ovarian stem cells: From basic to clinical applications

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    The field of reproductive biology has undergone significantdevelopments in the last decade. The notion thatthere is a fixed reserve pool of oocytes before birth wasestablished by Zuckerman in 1951. However, in 2004,an article published in nature challenged this centraldogma of mammalian reproductive biology. Tilly's groupreported the existence of ovarian germline stem cells(GSCs) in postnatal ovaries of mice and suggested thatthe bone marrow could be an extragonadal source ofovarian GSCs. These findings were strongly criticized;however, several independent groups have sincesuccessfully isolated and characterized ovarian GSCsin postnatal mice. The ovarian GSCs are located in theovarian surface epithelium and express markers ofundifferentiated GSCs. When transplanted into mouseovaries, mouse ovarian GSCs could differentiate andproduce embryos and offspring. Similarly, in a recentstudy, ovarian GSCs were found to be present in theovaries of women of reproductive age. Conversely,there is increasing evidence that stem cells responsiblefor maintaining a healthy state in normal tissue maybe a source of some cancers, including ovarian cancer.Cancer stem cells (CSCs) have been found in manytissues, including ovaries. Some researchers havesuggested that ovarian cancer may be a result of thetransformation and dysfunction of ovarian GSCs withself-renewal properties. Drug resistant and metastasisgeneratingCSCs are responsible for many importantproblems affecting ovarian cancer patients. Therefore,the identification of CSCs will provide opportunitiesfor the development of new therapeutic strategies fortreatments for infertility and ovarian cancer. In thisarticle, we summarize the current understanding ofovarian GSCs in adult mammals, and we also discusswhether there is a relationship between GSCs and CSCs.

  17. Growth Culture Conditions and Nutrient Signaling Modulating Yeast Chronological Longevity

    Directory of Open Access Journals (Sweden)

    Júlia Santos

    2012-01-01

    Full Text Available The manipulation of nutrient-signaling pathways in yeast has uncovered the impact of environmental growth conditions in longevity. Studies using calorie restriction show that reducing glucose concentration of the culture media is sufficient to increase replicative and chronological lifespan (CLS. Other components of the culture media and factors such as the products of fermentation have also been implicated in the regulation of CLS. Acidification of the culture media mainly due to acetic acid and other organic acids production negatively impacts CLS. Ethanol is another fermentative metabolite capable of inducing CLS reduction in aged cells by yet unknown mechanisms. Recently, ammonium was reported to induce cell death associated with shortening of CLS. This effect is correlated to the concentration of NH4+ added to the culture medium and is particularly evident in cells starved for auxotrophy-complementing amino acids. Studies on the nutrient-signaling pathways regulating yeast aging had a significant impact on aging-related research, providing key insights into mechanisms that modulate aging and establishing the yeast as a powerful system to extend knowledge on longevity regulation in multicellular organisms.

  18. Ovarian masses in children and adolescents in China: analysis of 203 cases

    OpenAIRE

    Liu, Hongqian; Wang, Xiangao; Lu, Donghao; Liu, Zhihong; Shi, Gang

    2013-01-01

    Objective The true incidence of ovarian tumors in children is unknown. Few studies beyond case reports and case series have been published concerning pediatric ovarian tumors. Herein we review a large number of ovarian tumor cases. Methods The charts of 203 patients who presented with adnexal masses were reviewed. Results The patient’s ranged in age from 2 to 18 years (mean = 15.6 years), with 30 being premenarchal (14.8%). The incidence of ovarian tumor increases with age, especially in pati...

  19. CT imaging of ovarian yolk sac tumor with emphasis on differential diagnosis

    OpenAIRE

    Yang-Kang Li; Yu Zheng; Jian-Bang Lin; Gui-Xiao Xu; Ai-Qun Cai; Xiu-Guo Zhou; Guo-Jun Zhang

    2015-01-01

    Ovarian yolk sac tumors (YSTs) are rare neoplasms. No radiological study has been done to compare the imaging findings between this type of tumor and other ovarian tumors. Here we analyzed the CT findings of 11 pathologically proven ovarian YSTs and compared their imaging findings with 18 other types of ovarian tumors in the same age range. Patient age, tumor size, tumor shape, ascites and metastasis of two groups did not differ significantly (P > 0.05). A mixed solid-cystic nature, intratumo...

  20. Quality assessment of chronologies in Latin American pollen records: a contribution to centennial to millennial scale studies of environmental change

    Directory of Open Access Journals (Sweden)

    S. G. A. Flantua

    2015-04-01

    Full Text Available The newly updated inventory of the Latin American Pollen Database (LAPD offers an important overview of data available for multi-proxy and multi-site purposes. However, heterogeneous paleoecological databases are not suitable to be integrated without an uncertainty assessment of existing chronologies. Therefore, we collected all chronological control points and age model metadata from the LAPD literature to create a complementary chronological database of 5116 dates from 1097 pollen records. We start with an overview on chronological dating and reporting in Central and South America. Specific problems and recommendations for chronology reporting are discussed. Subsequently, we implement a temporal quality assessment of pollen records from northwest South-America to support research on climate forcers and responses at a centennial-millennial time-scale. New chronologies are generated for 233 pollen records based on updated calibration curves. Different time windows are discussed on sample resolution and temporal uncertainty. Approximately one in four pollen diagrams depicts < 500 years resolution data at the Younger Dryas/Holocene transition. Overall, our analyses suggest that the temporal resolution of multi-site syntheses of late Pleistocene fossil pollen records in the northwest South-America is ca. 240 years, a resolution which allows analysis of ecological responses to centennial-millennial-scale climate change during the last deglaciation.

  1. Adolescent Premature Ovarian Insufficiency Following Human Papillomavirus Vaccination

    OpenAIRE

    Little, Deirdre Therese; Ward, Harvey Rodrick Grenville

    2014-01-01

    Three young women who developed premature ovarian insufficiency following quadrivalent human papillomavirus (HPV) vaccination presented to a general practitioner in rural New South Wales, Australia. The unrelated girls were aged 16, 16, and 18 years at diagnosis. Each had received HPV vaccinations prior to the onset of ovarian decline. Vaccinations had been administered in different regions of the state of New South Wales and the 3 girls lived in different towns in that state. Each had been p...

  2. Malignant ovarian tumours in childhood in Britain, 1962-78.

    OpenAIRE

    La Vecchia, C; Morris, H. B.; Draper, G J

    1983-01-01

    The files of the Childhood Cancer Research Group and of the Oxford Survey of Childhood Cancers were scrutinized for all the ovarian neoplasms registered in England, Scotland and Wales in children under age 15 years throughout the period 1962-78. Among 172 cases confirmed as malignant ovarian tumours, 145 (84%) were tumours of germ cell origin (54 dysgerminomas, 36 malignant teratomas, 26 endodermal sinus tumours, 4 embryonal carcinomas, 2 pure choriocarcinomas, 20 mixed germ cell neoplasms, 3...

  3. Ovarian dysgerminoma in two sisters

    Directory of Open Access Journals (Sweden)

    Bander F Aldhafery

    2008-01-01

    Full Text Available Although rare, dysgerminomas are important irrespective of incidence because they affect women of reproductive age (i.e., <45 years. Dysgerminomas make up two thirds of all malignant ovarian neoplasms in women younger than 20 years. All dysgerminomas are considered malignant, but only one third of dysgerminomas behave aggressively. Their exact etiology has not been determined. Few reports are found in the review of the literature on the incidence of dysgerminoma and other germ cell tumors in families. Some of these reports focus on the genetic abnormalities associated with germ cell tumor and the responsible gene. Two cases of dysgerminomas diagnosed in two sisters aged 14 and 19 years old are presented here with their radiological studies.

  4. CHARACTERISTICS OF MORTALITY RATES FROM BREAST AND OVARIAN CANCER IN JAPAN

    Institute of Scientific and Technical Information of China (English)

    LI Xiang-ming李湘鸣; LUO Fang-ni罗方妮; Akio Sato

    2004-01-01

    Objective: Breast and ovarian cancer is rare in Japan compared with other developed countries but their mortality rates are increasing. It is necessary to examine the experience of Japan as a guide to further prevent breast and ovarian cancer in our country. Methods: We conducted an epidemiological study of breast and ovarian cancer in the past 50 years to investigate the trends and characteristics of the mortality rates in Japan. The numbers of age-specific death from breast and ovarian cancer and the population of 5-year groups were obtained from the Vital Statistics of Japan. The truncated age specific mortality rates were calculated according to the patterns of age specific mortality rates from both cancers. Age adjustments were made to the standard world population. Results: In the past 50 years, mortality rates of breast and ovarian cancer increased about 2 or 6 fold, respectively. This increase was most marked over 50 years old. The death pattern of breast cancer was same as that of ovarian cancer, but that of ovarian cancer changed greatly with time. The birth cohort study had some interesting findings. Common to breast and ovarian cancer, the later the year of birth, the higher the mortality rates from both malignancies in later life. Conclusion: The increase of the yearly mortality rates from breast and ovarian cancer might be due to changes in lifestyle and environmental factors. We are very concerned about dietary practices. Further investigation is needed to clarify the possible causes of animal food.

  5. Criticism of traditional chronology: How long will Scaliger survive?

    Directory of Open Access Journals (Sweden)

    Bukvić Rajko

    2005-01-01

    Full Text Available The paper considers the problems of current state and survival of traditional chronology and history based upon the Scaliger and Petavius books from XVI and XVII centuries. Among many approaches that insist on the need of examination of that chronology, developed at first in Russia, but also in Germany, England, USA and other countries, author focuses to the investigation of Fomenko and his collaborators, but also the Khronotron group. Both these groups, like many others critics of current chronology, as their inspirators and predecessors mark Newton and Morozov, two great scientists who during many decades (! intensively considered problems of examination of chronology and history.

  6. Developing inorganic carbon-based radiocarbon chronologies for Holocene lake sediments in arid NW China

    Science.gov (United States)

    Zhang, Jiawu; Ma, Xueyang; Qiang, Mingrui; Huang, Xiaozhong; Li, Shuang; Guo, Xiaoyan; Henderson, Andrew C. G.; Holmes, Jonathan A.; Chen, Fahu

    2016-07-01

    Inorganic carbonates are often used to establish radiocarbon (14C) chronologies for lake sediments when terrestrial plant remains (TPR) are rare or when bulk organic matter is insufficient for dating, a problem that is common for many lakes in arid regions. However, the reservoir effect (RE), as well as old carbon contributed from the lakes catchment make it difficult to establish reliable chronologies. Here we present a systematic study of inorganic 14C ages of two lake-sediment sequences, one from a small-enclosed saline lake - Lake Gahai in Qaidam Basin, and the other from a large freshwater lake - Lake Bosten in Xinjiang. Modern dissolved inorganic carbon (DIC) of the lakes, paleo-lake sediments exposed in the catchment, and mollusk shells in core sediments from Lake Gahai were dated to assess the RE and the contribution of pre-aged carbon to the old ages in the cores. We propose a statistical regression to assess more than one RE for the 14C carbonate ages within our sedimentary sequences. Old radiocarbon ages contributed by detrital carbonates were assessed by comparing the ages of mollusk shells with those of carbonates at the same sediment depths. We established the RE of the authigenic component and assessed detrital old carbon contributions to our two sites, and this was used to correct the 14C ages. Based on this approach, we developed age models for both cores, and tested them using 210Pb ages in both cores and TPR-based 14C-ages recovered from Lake Bosten. We further tested our age models by comparing carbonate-based oxygen isotope (δ18O) records from both lakes to an independently-dated regional speleothem δ18O record. Our results suggest if sedimentary sequences are densely dated and the RE and the contribution of old carbon from detrital carbonates can be ascertained, robust chronological frameworks based on carbonate-based 14C determinations can be established.

  7. Anti-Müllerian Hormone as a marker of ovarian reserve in relation to cardio-metabolic health : A narrative review

    NARCIS (Netherlands)

    De Kat, Annelien C.; Broekmans, Frank J M; Laven, Joop S.; Van Der Schouw, Yvonne T.

    2015-01-01

    The final hallmark of diminishing ovarian reserve is menopause, a state known to be inextricably linked to the deterioration of female cardiovascular health. The menopausal transition is associated with an increased risk of future cardiovascular morbidity and mortality, irrespective of chronological

  8. The chronology of third molar mineralization by digital orthopantomography.

    Science.gov (United States)

    Maled, Venkatesh; Vishwanath, S B

    2016-10-01

    The present study was designed to determine the chronology of third molar mineralization to establish Indian reference data and to observe the advantages of digital orthopantomography. Therefore, a cross-sectional study was undertaken by evaluating 167 digital orthopantomographs in order to assess the mineralization status of the mandibular third molar of Caucasian individuals (85 males and 82 females) between the age of 14 and 24. The evaluation was carried out using the 8-stage developmental scheme of Demirjian et al (1973). The range, mean age, standard deviation and Student t-test are presented for each stage of mineralization in all four quadrants. Statistically significant differences between males and females were not found for all four third molars. All the individuals in this study with mature third molar were at least 18 years of age. For medicolegal purposes, the likelihood of whether an Indian is older than 18 years or not was determined. The advantage of digital orthopantomography in the interpretation of the tooth mineralization over the traditional method was acknowledged. PMID:27485643

  9. The chronology of third molar mineralization by digital orthopantomography.

    Science.gov (United States)

    Maled, Venkatesh; Vishwanath, S B

    2016-10-01

    The present study was designed to determine the chronology of third molar mineralization to establish Indian reference data and to observe the advantages of digital orthopantomography. Therefore, a cross-sectional study was undertaken by evaluating 167 digital orthopantomographs in order to assess the mineralization status of the mandibular third molar of Caucasian individuals (85 males and 82 females) between the age of 14 and 24. The evaluation was carried out using the 8-stage developmental scheme of Demirjian et al (1973). The range, mean age, standard deviation and Student t-test are presented for each stage of mineralization in all four quadrants. Statistically significant differences between males and females were not found for all four third molars. All the individuals in this study with mature third molar were at least 18 years of age. For medicolegal purposes, the likelihood of whether an Indian is older than 18 years or not was determined. The advantage of digital orthopantomography in the interpretation of the tooth mineralization over the traditional method was acknowledged.

  10. Sonographic Quantification of Ovarian Volumes in an adult Nigeria population

    Directory of Open Access Journals (Sweden)

    Dr. Nzotta Christian

    2009-01-01

    Full Text Available This study was conducted to establish the normal values of ovarian volumes in this locality. A convenience sample of 141 apparently and gynecologically healthy and non pregnant females was studied using transabdominal sonography. The length, width and anteroposterior dimensions of both the right and left ovaries were measured. Volumes of the ovaries were determined using the prolate ellipsoid formula. The mean ovarian volumes were found to be a 9.5cm3 and 10.cm3 for the right and left ovaries respectively. A mean ovarian volume (Right and left was 9.9cm3. A mean (right and left range of 5.3cm3 to 13.9cm3 was also established. Significant correlations were noted between ovarian volumes and age (r=0.93, p<0.05 and between ovarian volumes and body weight (r=0.73, p<0.05. This study has established a nomogram for ovarian sizes in this locality which would offer a valid method of evaluating ovarian volumes in clinical practice.

  11. Origin and chronology of chondritic components: A review

    Science.gov (United States)

    Krot, A. N.; Amelin, Y.; Bland, P.; Ciesla, F. J.; Connelly, J.; Davis, A. M.; Huss, G. R.; Hutcheon, I. D.; Makide, K.; Nagashima, K.; Nyquist, L. E.; Russell, S. S.; Scott, E. R. D.; Thrane, K.; Yurimoto, H.; Yin, Q.-Z.

    2009-09-01

    Mineralogical observations, chemical and oxygen-isotope compositions, absolute 207Pb- 206Pb ages and short-lived isotope systematics ( 7Be- 7Li, 10Be- 10B, 26Al- 26Mg, 36Cl- 36S, 41Ca- 41K, 53Mn- 53Cr, 60Fe- 60Ni, 182Hf- 182W) of refractory inclusions [Ca,Al-rich inclusions (CAIs) and amoeboid olivine aggregates (AOAs)], chondrules and matrices from primitive (unmetamorphosed) chondrites are reviewed in an attempt to test (i) the x-wind model vs. the shock-wave model of the origin of chondritic components and (ii) irradiation vs. stellar origin of short-lived radionuclides. The data reviewed are consistent with an external, stellar origin for most short-lived radionuclides ( 7Be, 10Be, and 36Cl are important exceptions) and a shock-wave model for chondrule formation, and provide a sound basis for early Solar System chronology. They are inconsistent with the x-wind model for the origin of chondritic components and a local, irradiation origin of 26Al, 41Ca, and 53Mn. 10Be is heterogeneously distributed among CAIs, indicating its formation by local irradiation and precluding its use for the early solar system chronology. 41Ca- 41K, and 60Fe- 60Ni systematics are important for understanding the astrophysical setting of Solar System formation and origin of short-lived radionuclides, but so far have limited implications for the chronology of chondritic components. The chronological significance of oxygen-isotope compositions of chondritic components is limited. The following general picture of formation of chondritic components is inferred. CAIs and AOAs were the first solids formed in the solar nebula ˜4567-4568 Myr ago, possibly within a period of events in nebular region(s) with high ambient temperature (at or above condensation temperature of forsterite), either throughout the inner protoplanetary disk (1-4 AU) or in a localized region near the proto-Sun ( -10‰) and have ( 26Al/ 27Al) 0 similar to those in chondrules (events in regions with low ambient temperature

  12. Retropancreatic Ovarian Tumor.

    Science.gov (United States)

    Acharya, Soumyo Ranjan; Dasgupta, Prosenjit; Das, Subhobroto; Halder, Sandip; Panda, Nilanjan

    2016-06-01

    Retroperitoneal mucinous cystadenomas are rare lesions (less than 50 reported) characterized by presence of ovary like stroma of unknown origin. However, germinal component of ovary has never been found in them. The pancreas occasionally gives rise to mucinous cystadenomas, but they are always intrapancreatic. We report a unique case of a rare retroperitoneal mucinous cystadenomas with presence of ovarian follicles in a 45-year-old lady who presented with an abdominal mass. This was successfully excised. Though retroperitoneal mucinous cystadenomas are rare, presence of ovarian follicle (germ cell) in them has never been reported before. PMID:27358520

  13. Jewish Holocaust Histories and the Work of Chronological Narratives

    Science.gov (United States)

    Silverstein, Jordana

    2012-01-01

    This article examines the ways that, in Holocaust education in Jewish schools in Melbourne and New York at the beginning of the 21st century, knowledge of the Holocaust is transferred to students in chronological form. It begins by asking: What work do chronological narratives do within the Holocaust historical narratives offered within Jewish…

  14. Time and Chronology: Conjoined Twins or Distant Cousins?

    Science.gov (United States)

    Blow, Frances; Lee, Peter; Shemilt, Denis

    2012-01-01

    Weaknesses in pupils' grasp of historical chronology are a commonplace in popular discussion of the state of history education. However, as Blow, Lee and Shemilt argue, although undoubtedly necessary and fundamental, mastery of chronological conventions is not sufficient: the difficulties that pupils experience when learning history are…

  15. Clinical study of anti-Mullerian hormone in prediction of ovarian aging%抗苗勒管激素与年龄的关系及其预测卵巢衰老的临床研究

    Institute of Scientific and Technical Information of China (English)

    高丽虹; 蔡文伟; 朱琴; 李永祥; 金倩燕; 张梅光; 蔡英如; 周芝婷; 吴晓杰

    2015-01-01

    childbearing age could provide reference for the evaluation of ovarian function.

  16. A retrospective study of ovarian cysts

    OpenAIRE

    Shivaji Neelgund; Panchaksharayya Hiremath

    2016-01-01

    Background: The ovaries are paired sex glands or gonads in female and are concerned with germ cell maturation, storage and its release. The ovaries are also concerned with steroidogenesis. The ovary is covered by a single layer of cuboidal cells known as germinal epithelium. As per the clinical features of the benign ovarian tumors, benign tumors predominantly manifest in late reproductive age. Methods: This retrospective study is conducted in SVMCH and RC, Ariyur, Pondicherry. During the...

  17. Testing teleconnections - chronological uncertainties of independently dated and tuned past climate events (Invited)

    Science.gov (United States)

    Blaauw, M.; Wohlfarth, B.

    2010-12-01

    Multiple fossil proxy archives are often dated by aligning purportedly simultaneous events between data sets. Examples are synchronising peat layers across countries or continents, orbital tuning, and dating cores through aligning proxy features with δ18O series from marine and ice deposits. Any temporal mismatch between multiple sites are then attributed to chronological errors, e.g., changing 14C age offsets, unidentified hiatuses or other mistakes in age-models. However, tuning involves the real danger of erroneously "sucking" separate events into one illusionary event, or vice versa. As an alternative, past climate events can be dated independently (e.g. using 14C dating), while explicitly quantifying their chronological uncertainties. Instead of assuming simultaneous climate events between multiple archives, the age models are kept separate, and the timing of events tested by calculating the probability of simultaneous events within a defined period of time. The method is tested by comparing Dansgaard/Oeschger-like events in two well-dated sites; Les Echets in France and NGRIP in Greenland. Chronological uncertainties are so high that we cannot safely assume that climate events were synchronous between sites at decadal to multi-centennial time scales. Past climate research would profit if tuning procedures would become more quantitative, reliable and objective. Ideally, individual proxy archives should not be tuned, and kept on independent time-scales.

  18. Application of Bomb Radiocarbon Chronologies to Shortfin Mako (Isurus oxyrinchus)

    Energy Technology Data Exchange (ETDEWEB)

    Ardizzone, D; Cailliet, G M; Natanson, L J; Andrews, A H; Kerr, L A; Brown, T A

    2007-07-16

    and the number of samples for MIA analysis was insufficient for some months. Hence, unequivocal validation of shortfin mako age estimates has yet to be accomplished. Atmospheric testing of thermonuclear devices in the 1950s and 1960s effectively doubled the natural atmospheric radiocarbon ({sup 14}C). The elevated {sup 14}C levels were first recorded in 1957-58, with a peak around 1963. As a consequence, {sup 14}C entered the ocean through gas exchange with the atmosphere at the ocean surface and in terrestrial runoff. Despite variable oceanographic conditions, a worldwide rise of the bomb {sup 14}C signal entered the ocean mixed layer as dissolved inorganic carbon (DIC) in 1957-58. The large amounts of {sup 14}C released from the bomb tests produced a signature that can be followed through time, throughout the marine food web, and into deeper waters. The marked increase of radiocarbon levels was first measured in the DIC of seawater and in biogenic marine carbonates of hermatypic corals in Florida. Subsequently, this record was documented in corals from other regions and in the thallus of rhodoliths. The accumulation of radiocarbon in the hard parts of most marine organisms in the mixed layer (such as fish otoliths and bivalves) was synchronous with the coral time-series. This technique has been used to validate age estimates and longevity of numerous bony fishes to date, as well as to establish bomb radiocarbon chronologies from different oceans. In the first application of this technique to lamnoid sharks, validated annual band-pair deposition in vertebral growth bands for the porbeagle (Lamna nasus) aged up to 26 years. Radiocarbon values from samples obtained from 15 porbeagle caught in the western North Atlantic Ocean (some of which were known-age) produced a chronology similar in magnitude to the reference carbonate chronology for that region. The observed phase shift of about 3 years was attributed to different sources of carbon between vertebrae and those for

  19. Evolução do perfil neuromotor e capacidade funcional de mulheres fisicamente ativas de acordo com a idade cronológica Evolución del perfil neuromotor y la capacidad funcional de mujeres fisicamente activas de acuerdo con la edad cronológica Evolution of neuromotor profile and functional capacity of physically active women according to chronological age

    Directory of Open Access Journals (Sweden)

    Sandra Mahecha Matsudo

    2003-11-01

    é comparar la evolución del perfil neuromotor y la capacidad funcional de mujeres activas en el período de un año de acuerdo con la edad cronológica. MÉTODOS: La muestra estuvo compuesta por 117 mujeres de 50 a 79 años de edad (: 65 ± 6,6 años participantes de un programa de ejercicios aeróbicos, dos veces por semana, 50 minutos por sesión durante 5,4 ± 3,0 años y divididas por la edad: 50-59 (n: 23; 60-69 (n: 60; 70-79 (n: 34. Los tests neuromotores y de movilidad incluyeron: fuerza muscular de los miembros inferiores y superiores, agilidad, flexibilidad de tronco, velocidad de levantarse de la silla, equilíbrio estático, velocidad normal de andar y velocidad máxima de andar. Los resultados iniciales de las dos evaluaciones siguientes, realizadas intérvalos de 6 meses, fueron comparados usando ANOVA two way, con post-hoc Bonferroni. RESULTADOS: En un ano no hubo ninguna alteración del desempeño neuromotor, ya que la velocidad de levantar de la silla y la velocidad de andar no evidenciaron diferencias significativas en los grupos de 50-59 e 60-69 años, presentando resultados un 10-20% mejores; en cuanto a la velocidad máxima de andar hubo una mejora (8% en los grupos de 60 a 79 años. CONCLUSIÓN: La evolución de la aptitud física y la capacidad funcional tuvo un comportamiento similar, en mujeres físicamente activas independientemente de la edad cronológica. Esta evolución fortalece la hipótesis de un efecto favorable de la actividad física regular en la promoción de la salud, estrategia fundamental del envejecimiento saludable.BACKGROUND AND PURPOSE: There are few longitudinal studies to determine the effect of aging on physical fitness and functional capacity of physically active women. The purpose of this study was to compare the evolution of neuromotor profile and functional capacity in active elderly women in one-year period as related to chronological age at the base line. METHODS: Sample consisted of 117 women from 50 to 79 years of age

  20. Managing hereditary ovarian cancer

    NARCIS (Netherlands)

    Mourits, M. J.; de Bock, G. H.

    2009-01-01

    In this review we present an overview of recent developments in the management of hereditary ovarian cancer. Until recently, intensive screening of the ovaries was recommended to mutation carriers and their first-degree female relatives. However, since screening is not effective in detecting early-s

  1. Ovarian cavernous hemangioma.

    Science.gov (United States)

    Alvarez, M; Cerezo, L

    1986-01-01

    Vascular tumors of the female genital tract are rare, especially those of the ovary. Most cases are small lesions that are discovered incidentally. We describe a 68-year-old woman with a benign hemangioma that presented clinically as a very large ovarian mass. PMID:3753575

  2. Childhood ovarian malignancy.

    Science.gov (United States)

    Mahadik, Kalpana; Ghorpade, Kanchanmala

    2014-04-01

    Objective of this article is to appraise diagnostic aspects and treatment modalities in childhood ovarian tumor in background of available evidence. Literature search on Pubmed revealed various aspects of epidemiology, histopathological diagnosis, and treatment of pediatric ovarian tumor. 85 % of childhood tumors are germ cell tumors. The varied histopathological picture in germ cell tumors poses a diagnostic and therapeutic challenge. Immunohistochemistry and newer genetic markers like SALL4 and karyopherin-2 (KPNA2) have been helpful in differentiating ovarian yolk sac tumor from dysgerminoma, teratomas, and other pictures of hepatoid, endometrioid, clear cell carcinomatous, and adenocarcinomatous tissues with varied malignant potential. Before platinum therapy, these tumors were almost fatal in children. Fertility-conserving surgery with bleomycin, etoposide, and cisplatin has dramatically changed the survival rates in these patients. This modality gives cancer cure with healthy offspring to female patients with childhood ovarian tumor. Evidence also supports this protocol resulting in successful pregnancy rates and safety of cytotoxic drugs in children born to these patients. PMID:24757335

  3. Polycystic ovarian syndrome

    OpenAIRE

    Nina Madnani; Kaleem Khan; Phulrenu Chauhan; Girish Parmar

    2013-01-01

    Polycystic ovarian syndrome (PCOS) is a "multispeciality" disorder suspected in patients with irregular menses and clinical signs of hyperandrogenism such as acne, seborrhoea, hirsutism, irregular menses, infertility, and alopecia. Recently, PCOS has been associated with the metabolic syndrome. Patients may develop obesity, insulin resistance, acanthosis nigricans, Type 2 diabetes, dyslipidemias, hypertension, non-alcoholic liver disease, and obstructive sleep apnoea. Good clinical examinatio...

  4. National Ovarian Cancer Coalition

    Science.gov (United States)

    ... 10, 2016 TESARO, Inc., an oncology-focused biopharmaceutical company, and ENGOT, the European Network for Gynecological Oncological Trial groups, today announced the presentation ... Read More NOCC Launches NOCC CancerConnect Community Social Media Network for Women with Ovarian Cancer September ...

  5. Availability of Amino Acids Extends Chronological Lifespan by Suppressing Hyper-Acidification of the Environment in Saccharomyces cerevisiae.

    Directory of Open Access Journals (Sweden)

    Yo Maruyama

    Full Text Available The chronological lifespan of Saccharomyces cerevisiae represents the duration of cell survival in the postdiauxic and stationary phases. Using a prototrophic strain derived from the standard auxotrophic laboratory strain BY4742, we showed that supplementation of non-essential amino acids to a synthetic defined (SD medium increases maximal cell growth and extends the chronological lifespan. The positive effects of amino acids can be reproduced by modulating the medium pH, indicating that amino acids contribute to chronological longevity in a cell-extrinsic manner by alleviating medium acidification. In addition, we showed that the amino acid-mediated effects on extension of chronological longevity are independent of those achieved through a reduction in the TORC1 pathway, which is mediated in a cell-intrinsic manner. Since previous studies showed that extracellular acidification causes mitochondrial dysfunction and leads to cell death, our results provide a path to premature chronological aging caused by differences in available nitrogen sources. Moreover, acidification of culture medium is generally associated with culture duration and cell density; thus, further studies are required on cell physiology of auxotrophic yeast strains during the stationary phase because an insufficient supply of essential amino acids may cause alterations in environmental conditions.

  6. Chronology of Postglacial Eruptive Activity and Calculation of Eruption Probabilities for Medicine Lake Volcano, Northern California

    Science.gov (United States)

    Nathenson, Manuel; Donnelly-Nolan, Julie M.; Champion, Duane E.; Lowenstern, Jacob B.

    2007-01-01

    Medicine Lake volcano has had 4 eruptive episodes in its postglacial history (since 13,000 years ago) comprising 16 eruptions. Time intervals between events within the episodes are relatively short, whereas time intervals between the episodes are much longer. An updated radiocarbon chronology for these eruptions is presented that uses paleomagnetic data to constrain the choice of calibrated ages. This chronology is used with exponential, Weibull, and mixed-exponential probability distributions to model the data for time intervals between eruptions. The mixed exponential distribution is the best match to the data and provides estimates for the conditional probability of a future eruption given the time since the last eruption. The probability of an eruption at Medicine Lake volcano in the next year from today is 0.00028.

  7. Ovarian differentiation and development in cachara Pseudoplatystoma fasciatum.

    Science.gov (United States)

    Valentin, F N; Batlouni, S R; Nascimento, N F; Silva, R C; Manzini, B; Hilbig, C C; Pereira-Santos, M; Nakaghi, L S O

    2016-07-01

    One thousand five hundred cachara or tiger shovelnose catfish Pseudoplatystoma fasciatum, obtained from induced reproduction, were used to determine the onset of ovarian differentiation and development and to record the main characteristics of this process. Samples were collected from 0 to 240 days post-fertilization (dpf) and the results classified into stages I-XII. Ovarian formation was histologically detected for the first time when juveniles measured mean ± s.d. 51·5 ± 8·3 mm total length (LT ) at 39-45 dpf (stages I-V), with intense somatic cell proliferation originating in the ovarian cavity. Both LT and age of fish had a positive correlation (P r(2)  = 0·95) than age (r(2)  = 0·85), especially during the initial stages of development. From stages VI to VII, the ovarian cavity was enlarged and undifferentiated oogonia were present. At stage VIII, small projections formed in the ovarian stroma towards the ventral region of the gonad (future ovarian lamellae) and the basal membrane and differentiated oogonia nests could be seen. At stages IX and X, the germ cells entered meiosis and folliculogenesis was completed by stages XI and XII, which can be considered late in comparison to other Siluriformes. This study has demonstrated that ovarian differentiation in P. fasciatum begins with an intense proliferation of squamous epithelial cells (somatic cells) during the early stages of development and that sex inversion protocols could, thus, be applied successfully before this period. Furthermore, the results have demonstrated that both size and age can influence gonad differentiation and development in this species. PMID:27401482

  8. Gemcitabine Hydrochloride With or Without WEE1 Inhibitor MK-1775 in Treating Patients With Recurrent Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

    Science.gov (United States)

    2016-09-19

    Ovarian Brenner Tumor; Ovarian Carcinosarcoma; Ovarian Clear Cell Cystadenocarcinoma; Ovarian Endometrioid Adenocarcinoma; Ovarian Mucinous Cystadenocarcinoma; Ovarian Seromucinous Carcinoma; Ovarian Serous Cystadenocarcinoma; Ovarian Serous Surface Papillary Adenocarcinoma; Recurrent Fallopian Tube Carcinoma; Recurrent Ovarian Carcinoma; Recurrent Primary Peritoneal Carcinoma; Undifferentiated Ovarian Carcinoma

  9. Animal models of ovarian cancer

    OpenAIRE

    Shaw Tanya J; Vanderhyden Barbara C; Ethier Jean-François

    2003-01-01

    Abstract Ovarian cancer is the most lethal of all of the gynecological cancers and can arise from any cell type of the ovary, including germ cells, granulosa or stromal cells. However, the majority of ovarian cancers arise from the surface epithelium, a single layer of cells that covers the surface of the ovary. The lack of a reliable and specific method for the early detection of epithelial ovarian cancer results in diagnosis occurring most commonly at late clinical stages, when treatment is...

  10. Ovarian pregnancy: an unusual presentation

    Directory of Open Access Journals (Sweden)

    Ayesha Arif Hussain

    2016-08-01

    Full Text Available Ovarian pregnancy is a rare type of ectopic pregnancy and usually, it ends with rupture before the end of the first trimester. The clinical picture generally mimics that of ruptured tubal ectopic pregnancy and hemorrhagic ovarian cyst. Transvaginal sonography may be helpful. We report a rare primary ruptured ovarian pregnancy in a 23 years lady. [Int J Reprod Contracept Obstet Gynecol 2016; 5(8.000: 2888-2890

  11. A histopathological overview of ovarian lesions in Benin City, Nigeria: How common are the functional cysts?

    Directory of Open Access Journals (Sweden)

    Gerald Dafe Forae

    2014-07-01

    Full Text Available Aim: The aim of this study is to highlight the histopathological synopsis of ovarian lesions with emphasis on functional ovarian cysts and to compare our study with findings of other centers. Materials and Methods: Hematoxylin and eosin stained-slides of ovarian biopsies diagnosed at the Ashamas Foundation Diagnostic Centre, Benin City for 10 years were archived, scrutinized, and studied. Request forms were analyzed for clinical biodata and diagnosis, and data were analyzed with Statistical Package for Social Sciences (SPSS version 17. Results: A total of 236 ovarian biopsies were reviewed. Of this, 121 (51.3% were nonneoplastic. Again 79 (33.5% were benign neoplastic tumors and 36 (15.6% were malignant tumors. Out of the 121 nonneoplastic (functional cysts lesions, corpus luteal cyst was the most commonly encountered, constituting 41 (33.9%. The peaks age incidence for nonneoplastic and benign neoplastic lesions occurred in the 3 rd decade. Two peaks age incidence was noted for malignant tumors-5 th and 7 th decades. Germ cell tumor constituted the most common neoplastic ovarian tumor (n = 59; 51.8% diagnosed. Conclusion: Functional ovarian cysts were the most commonly encountered ovarian lesions in our locality. The most common variety of functional cyst was corpus luteal cyst and hemorrhagic cyst with majority occurring in the reproductive age groups. Among the ovarian tumors, germ cell tumors were the most commonly seen.

  12. Paleogene geology and chronology of southwestern Umnak Island, Aleutian Islands, Alaska ( USA).

    Science.gov (United States)

    McLean, H.; Hein, J.R.

    1984-01-01

    A slightly deformed marine sedimentary sequence reflecting volcanic arc sedimentation from late Eocene to early Oligocene is intruded by hypabyssal quartz diorite sills and small plutons with apparent ages of about 30 Ma, ie, middle Oligocene. Chemical data from igneous rocks exhibit calc-alkaline and tholeiitic volcanic arc differentiation trends. The fossil ages and radiometric dates from SW Umnak Island are similar to those reported from other central and E Aleutian islands, and indicate uniformity in the chronology and tectonic development of the archipelago during the Paleogene. Paleomagnetic data suggest possible northward movement but remain equivocal and more work is indicated. -after Authors

  13. Nutrient Limitation of Microbial Mediated Decomposition and Arctic Soil Chronology

    Science.gov (United States)

    Melle, C. J.; Darrouzet-Nardi, A.; Wallenstein, M. D.

    2012-12-01

    Soils of northern permafrost regions currently contain twice as much carbon as the entire Earth's atmosphere. Traditionally, environmental constraints have limited microbial activity resulting in restricted decomposition of soil organic matter in these systems and accumulation of massive amounts of soil organic carbon (SOC), however climate change is reducing the constraints of decomposition in arctic permafrost regions. Carbon cycling in nutrient poor, arctic ecosystems is tightly coupled to other biogeochemical cycles. Several studies have suggested strong nitrogen limitations of primary productivity and potentially warm-season microbial activity in these nutrient deficient soils. Nitrogen is required for microbial extracellular enzyme production which drives the decomposition of soil organic matter (SOM). Nitrogen limited arctic soils may also experience limitation via labile carbon availability despite the SOM rich environment due to low extracellular enzyme production. Few studies have directly addressed nutrient induced microbial limitation in SOC rich arctic tundra soils, and even less is known about the potential for nutrient co-limitation. Additionally, through the process of becoming deglaciated, sites within close proximity to one another may have experienced drastic differences in their effective soil ages due to the varied length of their active histories. Many soil properties and nutrient deficiencies are directly related to soil age, however this chronology has not previously been a focus of research on nutrient limitation of arctic soil microbial activity. Understanding of nutrient limitations, as well as potential co-limitation, on arctic soil microbial activity has important implications for carbon cycling and the ultimate fate of the current arctic SOC reservoir. Analyses of nutrient limitation on soils of a single site are not adequate for fully understanding the controls on soil microbial activity across a vast land mass with large variation in

  14. Dominance and Age in Bilingualism

    Science.gov (United States)

    Birdsong, David

    2014-01-01

    The present article examines the relationship between age and dominance in bilingual populations. Age in bilingualism is understood as the point in development at which second language (L2) acquisition begins and as the chronological age of users of two languages. Age of acquisition (AoA) is a factor in determining which of a bilingual's two…

  15. Tubo-ovarian actinomycosis.

    OpenAIRE

    Shroff C; Deodhar K; Patkar V; Fonseca J

    1981-01-01

    Actinomycotic infection of the female genital tract is rare. Actinomycosis is a chronic suppurative granulomatous infection that is characterized by formation of abscesses, multiple draining sinuses and appearance of tangled mycelial masses or granules in the discharges and tissue sections. 2 cases of tubo-ovarian actinomycosis are reported. The 1st case presented clinical with gastrointestinal symptoms and a ventral scar hernia following an operation for a non-healing abdominal wound 6 mo...

  16. Tubo-ovarian actinomycosis.

    Directory of Open Access Journals (Sweden)

    Shroff C

    1981-01-01

    Full Text Available Actinomycotic infection of the female genital tract is rare. Actinomycosis is a chronic suppurative granulomatous infection that is characterized by formation of abscesses, multiple draining sinuses and appearance of tangled mycelial masses or granules in the discharges and tissue sections. 2 cases of tubo-ovarian actinomycosis are reported. The 1st case presented clinical with gastrointestinal symptoms and a ventral scar hernia following an operation for a non-healing abdominal wound 6 months earlier. The 2nd case sought medical attention for backache and leucorrhea of 4 years′ duration. Exploratory laparotomy in the 1st case revealed tubo-ovarian masses; the vermiform appendix was not traceable. The uterine cavity in the 2nd case harbored a wooden stick. Direct extension from established ileocacal actinomycosis was believed to involve the female genital adnexae in the past. Association of tubo-ovarian actinomycosis with the presence of a foreign body in the female genital tract has been reported sporadically in the literature, yet an increase in the incidence may be expected because of the frequent use of intrauterine contraceptive devices in recent times. It is suggested that in women presenting clinically with vague abdominal symptoms, backache and discharge, actinomycosis should be considered and ruled out with the help of cytologic and proper microbial culture methods. Once the diagnosis is established, the infection can be treated with good results with penicillin.

  17. 孕马血清促性腺激素刺激后卵巢储备功能随年龄变化的研究%Ovarian reserve function in reproductive aging after Pregnant Mare serum Gonaaotropin stimulation

    Institute of Scientific and Technical Information of China (English)

    梁元晶; 徐长辉; KIM Beomsu; PERESIE Jennifer; YEH John

    2009-01-01

    Objective To measure serum anti-Mullerian hormone (AMH) levels in young, adult, and aging rats after PMSG stimulation. Methods Female SD rats were divided into young, adult, and aging groups according to their age. After PMSG stimula-tion, serum AMH levels were measured by ELISA. AMH positive follicles were showed by immunofluorescent staining. Results Serum AMH levels were (2.92±0.55 ) ng/mL, ( 1.90±0.11 ) ng/mL, and (0.80±0.08) ng/mL in young, adult, and aging rats, respec-tively, which was significant differences (P<0.05, young vs adult; P <0.001, young vs aging; P < 0.001, adult vs aging) ; total folli-cle counts were 57.3±5.5, 31.6±3.6, and 15.1±1.4 in young, adult, and aging rats, respectively, which was significant differ-ences (P<0.001, young vs adult; P<0. 001, young vs aging; P<0.05, adult vs aging) ; the numbers of AMH positive follicles were 9.2±2.0, 6.3±1.4, and 4.4±0.8 in young, adult and aging rats, respectively. Conclusion After PMSG stimulation, AMH-se-creting follicles and serum AMH levels are decreased significantly according to aging. AMH could be a good biological marker to predict ovarian reserve even after PMSG stimulation.%目的 探讨孕马血清促性腺激素(PMSG)刺激后不同年龄组雌性大鼠血清中抗中肾旁管激素(AMH)的变化规律,探讨PMSG刺激后AMH对预测卵巢储备功能的作用.方法 SD雌性大鼠分为幼年组、成年组和老年组.PMSG注射后54 h,运用ELISA和免疫荧光化学方法,检测血清和卵巢中AMH的表达.结果 血清AMH水平,幼年组(2.92±0.55)ng/mL,成年组(1.90±0.11)ng/mL,老年组(0.80±0.08)ng/mL,成年组与幼年组(P<0.05)、老年组与幼年组(P<0.001)、老年组与成年组(P<0.001)相比,差异具有统计学意义.卵巢中卵泡总数,幼年组57.3±5.5,成年组31.6±31.6,老年组15.1±1.4,成年组与幼年组(P<0.001)、老年组与幼年组(P<0.001)、老年组与成年组(P<0.05)相比,差异具有统计学意义.AMH

  18. An optimized multi-proxy, multi-site Antarctic ice and gas orbital chronology (AICC2012: 120–800 ka

    Directory of Open Access Journals (Sweden)

    H. Fischer

    2012-11-01

    Full Text Available An accurate and coherent chronological framework is essential for the interpretation of climatic and environmental records obtained from deep polar ice cores. Until now, one common ice core age scale has been developed based on an inverse dating method (Datice combining glaciological modelling with absolute and stratigraphic markers between 4 ice cores covering the last 50 ka (thousand of years before present (Lemieux-Dudon et al., 2010. In this paper, together with the companion paper of Veres et al. (2012, we present an extension of this work back to 800 ka for the NGRIP, TALDICE, EDML, Vostok and EDC ice cores using an improved version of the Datice tool. The AICC2012 (Antarctic Ice Core Chronology 2012 chronology includes numerous new gas and ice stratigraphic links as well as improved evaluation of background and associated variance scenarios. This paper concentrates on the long timescales between 120–800 ka. In this frame, new measurements of δ18Oatm over Marine Isotope Stage (MIS 11–12 on EDC and a complete δ18Oatm record of the TALDICE ice cores permit us to derive new orbital gas age constraints. The coherency of the different orbitally deduced ages (from δ18Oatm, δO2/N2 and air content has been verified before implementation in AICC2012. The new chronology shows only small differences, well within the original uncertainty range, when compared with the previous ice core reference age scale EDC3. For instance, the duration of the last four interglacial periods is not affected by more than 5%. The largest deviation between AICC2012 and EDC3 (4.4 ka is obtained around MIS 12. Despite significant modifications of the chronological constraints around MIS 5, now independent of speleothem records in AICC2012, the date of Termination II is very close to the EDC3 one.

  19. An epigenetic signature in peripheral blood predicts active ovarian cancer.

    Directory of Open Access Journals (Sweden)

    Andrew E Teschendorff

    Full Text Available BACKGROUND: Recent studies have shown that DNA methylation (DNAm markers in peripheral blood may hold promise as diagnostic or early detection/risk markers for epithelial cancers. However, to date no study has evaluated the diagnostic and predictive potential of such markers in a large case control cohort and on a genome-wide basis. PRINCIPAL FINDINGS: By performing genome-wide DNAm profiling of a large ovarian cancer case control cohort, we here demonstrate that active ovarian cancer has a significant impact on the DNAm pattern in peripheral blood. Specifically, by measuring the methylation levels of over 27,000 CpGs in blood cells from 148 healthy individuals and 113 age-matched pre-treatment ovarian cancer cases, we derive a DNAm signature that can predict the presence of active ovarian cancer in blind test sets with an AUC of 0.8 (95% CI (0.74-0.87. We further validate our findings in another independent set of 122 post-treatment cases (AUC = 0.76 (0.72-0.81. In addition, we provide evidence for a significant number of candidate risk or early detection markers for ovarian cancer. Furthermore, by comparing the pattern of methylation with gene expression data from major blood cell types, we here demonstrate that age and cancer elicit common changes in the composition of peripheral blood, with a myeloid skewing that increases with age and which is further aggravated in the presence of ovarian cancer. Finally, we show that most cancer and age associated methylation variability is found at CpGs located outside of CpG islands. SIGNIFICANCE: Our results underscore the potential of DNAm profiling in peripheral blood as a tool for detection or risk-prediction of epithelial cancers, and warrants further in-depth and higher CpG coverage studies to further elucidate this role.

  20. A 60 000 year Greenland stratigraphic ice core chronology

    Directory of Open Access Journals (Sweden)

    K. K. Andersen

    2007-11-01

    Full Text Available The Greenland Ice Core Chronology 2005 (GICC05 is a time scale based on annual layer counting of high-resolution records from Greenland ice cores. Whereas the Holocene part of the time scale is based on various records from the DYE-3, the GRIP, and the NorthGRIP ice cores, the glacial part is solely based on NorthGRIP records. Here we present an 18 kyr extension of the time scale such that GICC05 continuously covers the past 60 kyr. The new section of the time scale places the onset of Greenland Interstadial 12 (GI-12 at 46.9±1.0 kyr b2k (before year AD 2000, the North Atlantic Ash Zone 2 layer in GI-15 at 55.4±1.2 kyr b2k, and the onset of GI-17 at 59.4±1.3 kyr b2k. The error estimates are derived from the accumulated number of uncertain annual layers and can be regarded as 1σ uncertainties. In the 40–60 kyr interval the new time scale has a discrepancy with the Meese-Sowers GISP2 time scale of up to 2.4 kyr, whereas GICC05 compares well to the dating of the Hulu Cave record with absolute age differences of less than 800 years throughout the 60 kyr period. The new time scale is generally in close agreement with other independently dated records and reference horizons, such as the Laschamp geomagnetic excursion and the Kleegruben speleothem record from the Austrian Alps, suggesting high accuracy of both event durations and absolute age estimates.

  1. A 60 000 year Greenland stratigraphic ice core chronology

    Directory of Open Access Journals (Sweden)

    A. Svensson

    2008-03-01

    Full Text Available The Greenland Ice Core Chronology 2005 (GICC05 is a time scale based on annual layer counting of high-resolution records from Greenland ice cores. Whereas the Holocene part of the time scale is based on various records from the DYE-3, the GRIP, and the NorthGRIP ice cores, the glacial part is solely based on NorthGRIP records. Here we present an 18 ka extension of the time scale such that GICC05 continuously covers the past 60 ka. The new section of the time scale places the onset of Greenland Interstadial 12 (GI-12 at 46.9±1.0 ka b2k (before year AD 2000, the North Atlantic Ash Zone II layer in GI-15 at 55.4±1.2 ka b2k, and the onset of GI-17 at 59.4±1.3 ka b2k. The error estimates are derived from the accumulated number of uncertain annual layers. In the 40–60 ka interval, the new time scale has a discrepancy with the Meese-Sowers GISP2 time scale of up to 2.4 ka. Assuming that the Greenland climatic events are synchronous with those seen in the Chinese Hulu Cave speleothem record, GICC05 compares well to the time scale of that record with absolute age differences of less than 800 years throughout the 60 ka period. The new time scale is generally in close agreement with other independently dated records and reference horizons, such as the Laschamp geomagnetic excursion, the French Villars Cave and the Austrian Kleegruben Cave speleothem records, suggesting high accuracy of both event durations and absolute age estimates.

  2. Histopathological Distribution of Ovarian Masses Occurring After Hysterectomy: A Five-Year Assay in Iranian Patients

    Directory of Open Access Journals (Sweden)

    Lalooei

    2016-01-01

    Full Text Available Background Ovarian cancer, the third most important genital cancer and fifth cause of cancer-related death in women, is diagnosed at terminal stages in 70% of cases. Therefore, it is imperative to know the possible risk factors associated with ovarian cancer. Only a few studies have discussed the histopathological features of ovarian masses occurring after hysterectomy. Objectives The study aimed to investigate the five-year prevalence and histopathological distribution of ovarian masses after hysterectomy in Iranian patients and to determine the need for prophylactic salpingo-oophorectomy. Patients and Methods This descriptive cross-sectional study enrolled all patients with ovarian masses and a history of hysterectomy for benign conditions who were visiting the gynecology clinic of Baqiyatallah Hospital, Tehran, between May 2009 and May 2014. Demographic information, pathological features of ovarian masses, family history, the time between hysterectomy and ovarian mass surgery, and method of hysterectomy were recorded in a predesigned checklist. The level of tumor markers such as CA125 and alpha-fetoprotein (α-FP were measured. Results Of the 1052 patients with ovarian masses, 45patients (mean age, 53.11 ± 9.56 years who had undergone abdominal hysterectomy underwent analysis. The study participants had a mean age of 47.92 ± 1.58 years at the time of hysterectomy. The mean time interval between hysterectomy and diagnosis of ovarian mass was 5.38 ± 4.15 years. Based on pathological reports, serous cystadenoma was the most frequent (43.2% pathological diagnosis, followed by mucinous cystadenoma (17.5%. Conclusions A majority of ovarian masses, especially those diagnosed within a short duration after hysterectomy, are benign. Iranian patients with such ovarian masses when asymptomatic and associated with negative tumor markers could be followed up, and prophylactic oophorectomy may not be necessary.

  3. Lake trout otolith chronologies as multidecadal indicators of high-latitude freshwater ecosystems

    Science.gov (United States)

    Black, B.A.; Von Biela, V.R.; Zimmerman, C.E.; Brown, Randy J.

    2013-01-01

    High-latitude ecosystems are among the most vulnerable to long-term climate change, yet continuous, multidecadal indicators by which to gauge effects on biology are scarce, especially in freshwater environments. To address this issue, dendrochronology (tree-ring analysis) techniques were applied to growth-increment widths in otoliths from lake trout (Salvelinus namaycush) from the Chandler Lake system, Alaska (68.23°N, 152.70°W). All otoliths were collected in 1987 and exhibited highly synchronous patterns in growth-increment width. Increments were dated, the widths were measured, and age-related growth declines were removed using standard dendrochronology techniques. The detrended time series were averaged to generate an annually resolved chronology, which continuously spanned 1964–1984. The chronology positively and linearly correlated with August air temperature over the 22-year interval (p < 0.01), indicating that warmer summers were beneficial for growth, perhaps by increasing fish metabolic rate or lake productivity. Given the broad distribution of lake trout within North America, this study suggests that otolith chronologies could be used to examine responses between freshwater ecosystems and environmental variability across a range of temporal and spatial scales.

  4. Cultural and Chronological Horizons and the Problem of the Early Sarmatian Culture Formation

    Directory of Open Access Journals (Sweden)

    Yablonsky Leonid Teodorovich

    2015-12-01

    Full Text Available On the materials of Eurasian early nomads’ archaeology we highlight the South Ural cultural and historical area (UCHA. Geographically it includes steppe regions of West Kazakhstan, Chelyabinsk and Orenburg regions, steppe and forest steppe zones of the Republic of Bashkortostan. There were similar cultural processes that led to the Early Sarmatian archaeological culture formation in the Early Iron Age. Under the cultural and chronological horizon we understand the geographic region that is significantly larger than UCHA. Practically it has no geographic boundaries. Specificity of the horizon is that at a certain chronological stage (phase artifacts and their complexes, signs of spiritual culture are widely distributed that will mark the horizon – the horizon markers such as well known Scythian triad. Global chronological scheme of the Southern Trans-Urals cultural and historical area can be represented as follows: “Sauromatian” cultural and chronological horizon – the second half of the 6th – the end of the 4th (3rd centuries B.C. – Phase “A” – the second half of the 6th – the middle of the 5th centuries B.C. – Phase “B” – the second half of the 5th – the third quarter of the 4th centuries B.C. – Phase “C” – the third quarter of the 4th – the 3rd century B.C. Typologically the burial grounds like Filippovka I and Perevolochan can be attributed to the Early-Sarmatian archaeological culture, i.e. to the time of the ethnic consciousness formation of suspected archaeological Early Sarmatians. In this period ordinary mounds and graves appear along with the elite ones. It is advisable to consider the sites of the “Sauromatian” and Early-Sarmatian cultures of the South Urals of the end of the 5th-3rd centuries B.C. as a single culture of the early nomads.

  5. Estrogen, Progesterone and Epithelial Ovarian Cancer

    Directory of Open Access Journals (Sweden)

    Ho Shuk-Mei

    2003-10-01

    Full Text Available Abstract Ovarian carcinoma (OCa continues to be the leading cause of death due to gynecologic malignancies and the vast majority of OCa is derived from the ovarian surface epithelium (OSE and its cystic derivatives. Epidemiological evidence strongly suggests that steroid hormones, primarily estrogens and progesterone, are implicated in ovarian carcinogenesis. However, it has proved difficult to fully understand their mechanisms of action on the tumorigenic process. New convincing data have indicated that estrogens favor neoplastic transformation of the OSE while progesterone offers protection against OCa development. Specifically, estrogens, particularly those present in ovulatory follicles, are both genotoxic and mitogenic to OSE cells. In contrast, pregnancy-equivalent levels progesterone are highly effective as apoptosis inducers for OSE and OCa cells. In this regard, high-dose progestin may exert an exfoliation effect and rid an aged OSE of pre-malignant cells. A limited number of clinical studies has demonstrated efficacies of antiestrogens, aromatase inhibitors, and progestins alone or in combination with chemotherapeutic drugs in the treatment of OCa. As a result of increased life expectancy in most countries, the number of women taking hormone replacement therapies (HRT continues to grow. Thus, knowledge of the mechanism of action of steroid hormones on the OSE and OCa is of paramount significance to HRT risk assessment and to the development of novel therapies for the prevention and treatment of OCa.

  6. Pediatric ovarian tumors in a tertiary care hospital of Kolkata: An experience of last 5 years with its clinicopathological correlation

    OpenAIRE

    Senjuti Dasgupta; Debdas Bose; Nirmal Kumar Bhattacharyya; Arnab Chaudhuri; Kanika Gupta; Pranab Kumar Biswas

    2016-01-01

    Background: Pediatric ovarian tumors are rare with an approximate incidence of 2.6 per 100,000 girls per year. Aims and Objectives: This study was done to delineate the clinicopathological profile of pediatric ovarian masses encountered in a tertiary care hospital over 5 years. Materials and Methods: A retrospective study was conducted for a period of 5 years during which all patients whose age did not exceed 20 years and underwent surgical resection of ovarian masses, were included. History,...

  7. Imunotherapy opportunities in ovarian cancer

    Directory of Open Access Journals (Sweden)

    I. Zh. Shubina

    2013-01-01

    Full Text Available In the last decade, accumulated evidence in favor of that ovarian cancer is an immunogenic tumor. Immunotherapy is aimed at stimulating the innate and adaptive immunity, may cause an effective response in patients with ovarian cancer. Various approaches immunotherapy include cytokinetherapy, use of monoclonal antibodies and cell therapy.

  8. Cryobanking of human ovarian tissue

    DEFF Research Database (Denmark)

    Macklon, Kirsten Tryde; Ernst, Erik; Andersen, Anders Nyboe;

    2014-01-01

    Cryopreservation of ovarian tissue is one way of preserving fertility in young women with a malignant disease or other disorders that require gonadotoxic treatment. The purpose of the study was to explore how many women remained interested in continued cryostorage of their ovarian tissue beyond a...

  9. Gamma spectrometry for chronology of recent sediments

    Energy Technology Data Exchange (ETDEWEB)

    Pittauerova, Daniela

    2013-12-17

    This thesis deals with several aspects of gamma spectrometric analysis of natural and artificial isotopes in sediments and their use as tracers for qualification and quantification of accumulation and mixing processes in different aquatic environments. Sediment cores from three distinct areas including terrigenous sediments deposited on the continental slope off NW Africa, deep sea sediments off Sumba Island and five stations from the Gulf of Eilat in the Red Sea area were measured and interpreted within this dissertation. The main concern in gamma spectrometry of voluminous environmental samples is a reliable efficiency calibration. This is specially relevant for the analysis of low energy gamma emitters (<100 keV). {sup 210}Pb, an important isotopic tracer to cover the period of the last century, is one of them. Within this work mathematical efficiency calibration was applied using a commercial software package. A series of validation tests was performed and evaluated for point and voluminous samples. When using {sup 210}Pb as a tracer it is necessary to determine its excess portion, which is not supported by ingrowth from the parent nuclide {sup 226}Ra. Its analysis is mostly performed via short lived daughter isotopes that follow after the intermediate gaseous member {sup 222}Rn. Preventing the escape of radon from the sample is a critical step before analysis due to a negative effect of supported {sup 210}Pb underestimation on the chronology, which was also documented in this thesis. Time series registering ingrowth of {sup 214}Pb and {sup 214}Bi towards radioactive equilibrium with {sup 226}Ra in different containers were evaluated for analyses of {sup 226}Ra. Direct analyses of {sup 226}Ra was compared to its detection via daughter products. A method for aligning parallel radionuclide depth profiles was described and applied successfully in two case studies from the continental slope off NW Africa and off Sumba Island, Indonesia. This is primarily important

  10. Gamma spectrometry for chronology of recent sediments

    International Nuclear Information System (INIS)

    This thesis deals with several aspects of gamma spectrometric analysis of natural and artificial isotopes in sediments and their use as tracers for qualification and quantification of accumulation and mixing processes in different aquatic environments. Sediment cores from three distinct areas including terrigenous sediments deposited on the continental slope off NW Africa, deep sea sediments off Sumba Island and five stations from the Gulf of Eilat in the Red Sea area were measured and interpreted within this dissertation. The main concern in gamma spectrometry of voluminous environmental samples is a reliable efficiency calibration. This is specially relevant for the analysis of low energy gamma emitters (<100 keV). 210Pb, an important isotopic tracer to cover the period of the last century, is one of them. Within this work mathematical efficiency calibration was applied using a commercial software package. A series of validation tests was performed and evaluated for point and voluminous samples. When using 210Pb as a tracer it is necessary to determine its excess portion, which is not supported by ingrowth from the parent nuclide 226Ra. Its analysis is mostly performed via short lived daughter isotopes that follow after the intermediate gaseous member 222Rn. Preventing the escape of radon from the sample is a critical step before analysis due to a negative effect of supported 210Pb underestimation on the chronology, which was also documented in this thesis. Time series registering ingrowth of 214Pb and 214Bi towards radioactive equilibrium with 226Ra in different containers were evaluated for analyses of 226Ra. Direct analyses of 226Ra was compared to its detection via daughter products. A method for aligning parallel radionuclide depth profiles was described and applied successfully in two case studies from the continental slope off NW Africa and off Sumba Island, Indonesia. This is primarily important when combined profiles obtained from short multicorer cores

  11. Chronology of Holocene lacustrine sediments in Co Ngoin, central Tibetan Plateau

    Institute of Scientific and Technical Information of China (English)

    WU; Yanhong; WANG; Sumin; HOU; Xinhua

    2006-01-01

    Chronology is the basis for using lacustrine sediments to reconstruct the history of environmental change. Radioactive-nuclides such as 14C, 210Pb and 137Cs dating are mainly used to establish the chronology for recent several ten thousand years. Because of being mixed with "dead carbon", the measured 14C age is always older than the actual age which is recognized as "reservoir effect". Cs is a kind of active metal element, and easy to migrate vertically in the sediment that leads to the error of the time marker. 210Pb dating should make sure to select CIC model or CRS model. On the Tibetan Plateau, most of the lakes are alkaline closed lake where Cs is more moveable in the sediment and the reservoir effect caused by "dead carbon" on 14C dating is stronger. Based on the analysis on results of 14C, 210Pb and 137Cs of the lacustrine sediments from Co Ngoin, central Tibetan Plateau, we use the simple regression method to re-calculate the 14C calendar ages, and establish the time sequence for cores CE-1 and CE-2 with result of 210Pb CRS model for the upper 35 cm and recalculated 14C calendar age for sediments bellow 35 cm. Since 1400 cal. a BP, sedimentation interrupted for more than 1000 years. According to this time sequence, variations of environmental proxies confidently reflect the major climatic events in Holocene.

  12. Similar phenotype characteristics comparing familial and sporadic premature ovarian failure.

    NARCIS (Netherlands)

    Janse, F.; Knauff, E.A.; Niermeijer, M.F.; Eijkemans, M.J.; Laven, J.S.E.; Lambalk, C.B.; Fauser, B.C.J.M.; Goverde, A.J.

    2010-01-01

    OBJECTIVE: Premature ovarian failure (POF) is characterized by secondary amenorrhea before the age of 40 years, along with repeated increased follicle-stimulating hormone and low estrogen concentrations. POF is considered a complex genetic disease with a familial presentation in 12% to 50% of cases.

  13. Similar phenotype characteristics comparing familial and sporadic premature ovarian failure

    NARCIS (Netherlands)

    Janse, Femi; Knauff, Erik A. H.; Niermeijer, Martinus F.; Eijkemans, Marinus J.; Laven, Joop S. E.; Lambalk, Cornelius B.; Fauser, Bart C. J. M.; Goverde, Angelique J.; Hoek, Annemieke

    2010-01-01

    Objective: Premature ovarian failure (POF) is characterized by secondary amenorrhea before the age of 40 years, along with repeated increased follicle-stimulating hormone and low estrogen concentrations. POF is considered a complex genetic disease with a familial presentation in 12% to 50% of cases.

  14. Clear cell ovarian cancer and endometriosis: is there a relationship?

    Science.gov (United States)

    Suzin, Jacek; Obirek, Katarzyna; Sochacka, Amanda; Łoszakiewicz, Marta

    2016-01-01

    Introduction Ovarian clear cell carcinoma is a rare type of ovarian cancer. In recent years, issues of the common genetic origin of endometriosis and ovarian clear cell carcinoma have been raised. Aim of this study Aim of this study was to evaluate the prevalence of this type of cancer, risk factors, prognosis and its potential aetiological association with endometriosis. Material and methods In a retrospective study, we analysed histopathological data of patients operated in the First Department of Gynaecology and Obstetrics (MU, Lodz) due to ovarian cancer in 2004-2014. Among the 394 patients operated on for ovarian cancer, clear cell carcinoma was found in 0.02% (9/394). Menstrual history, parity, comorbidities, data from physical examination, operational protocols and histopathological diagnoses were analysed. Follow-up was obtained from 77.8% of patients. Statistical analysis was performed using Microsoft Excel 2013. Results The mean age of patients at diagnosis was 57.6 years; the BMI in the study group was 27.2; the majority of patients were multiparous (77.8%). Clear cell carcinoma was detected mostly at stage Ia (n = 4). The concentration of Ca125 in the study group had an average of 142.75 U/ml and a median of 69.3 U/ml. The coexistence of endometriosis could not be clinically or histologically confirmed amongst our patients. The most common comorbidity in the study group was hypertension. Conclusions In our clinical material, ovarian clear cell carcinoma is a rare histopathological specimen with a prognostic value comparable to that of serous ovarian cancer. Due to the rarity of this histopathological subtype, proving a cause-and-effect relationship between it and endometriosis can only be elucidated through statistical studies of the entire population.

  15. Gamma Spectrometry for Chronology of Recent Sediments. Tracing Human Induced Climate Change in NW Africa

    International Nuclear Information System (INIS)

    Gamma spectroscopy was used for the determination of radionuclides in sediment cores from the continental shelf off northwest africa to provide age control of the sediment record used for a study of aridification of the Sahel zone. 210Pb, 226Ra and 137Cs were measured in the upper part of a gravity core and the associated multicorer and used for aligning these cores. This provided information about the amount of sediment loss due to the sampling procedure in the upper part of the gravity core. The age model based on the matched profiles extended to 140 years B.P. and the rest of the gravity core was dated by 14C. The 210Pb age allowed the estimation of the local radiocarbon reservoir age. Application of 210Pb and 137Cs chronology helps to significantly extend paleoclimatic proxy data into the Anthropocene, thereby allowing the comparison of human induced climate change with natural climate variability. (author)

  16. Long-Term Moderate Oxidative Stress Decreased Ovarian Reproductive Function by Reducing Follicle Quality and Progesterone Production

    Science.gov (United States)

    Lai, Zhiwen; Tian, Yong; Fang, Li; Wu, Meng; Xiong, Jiaqiang; Qin, Xian; Luo, Aiyue; Wang, Shixuan

    2016-01-01

    Ovarian aging is a long-term and complex process associated with a decrease in follicular quantity and quality. The damaging effects of reactive oxygen species (ROS) in ovarian aging and ovarian aging-associated disorders have received relatively little attention. Thus, we assessed if the oxidative stress induced by long-term (defined by the Environmental Protection Agency as at least 30 days in duration) moderate ozone inhalation reduced ovarian reserves, decreased ovarian function and induced ovarian aging-associated disorders. The expression of oxidative stress markers and antioxidant enzymes was used to determine the degree of oxidative stress. Ultrastructural changes in ovarian cells were examined via electron microscopy. The ovarian reserve was assessed by measuring multiple parameters, such as the size of the primordial follicle pool and anti-Müllerian hormone (AMH) expression. The estrous cycle, hormone levels and fertility status were investigated to assess ovarian function. To investigate ovarian aging-associated disorders, we utilized bone density and cardiovascular ultrasonography in mice. The levels of oxidized metabolites, such as 8-hydroxy-2´-deoxyguanosine (8-OHdG), 4-hydroxynonenal (4-HNE) and nitrotyrosine (NTY), significantly increased in ovarian cells in response to increased oxidative stress. The ultrastructural analysis indicated that lipid droplet formation and the proportion of mitochondria with damaged membranes in granulosa cells were markedly increased in ozone-exposed mice when compared with the control group. Ozone exposure did not change the size of the primordial follicle pool or anti-Müllerian hormone (AMH) expression. The estrogen concentration remained normal; however, progesterone and testosterone levels decreased. The mice exposed to ozone inhalation exhibited a substantial decrease in fertility and fecundity. No differences were revealed by the bone density or cardiovascular ultrasounds. These findings suggest that the

  17. Analysis of computed tomography of ovarian tumor

    Energy Technology Data Exchange (ETDEWEB)

    Omura, Makoto; Taniike, Keiko; Nishiguchi, Hiroyasu

    1987-07-01

    One hundred and twenty six patients with ovarian mass were studied with computed tomography (CT) and classified into five groups according to its margin and inner structure. The incidence of malignancy of cystic ovarian mass with smooth margin was low and that of solid ovarian mass with irreglar margin was high. Three cases (6.7 %) of malignant ovarian tumor demonstrated completely cystic pattern. Ovarian teratomas contained well defined component of fat density.

  18. Reproductive System Outcome Among Patients with Polycystic Ovarian Syndrome.

    Science.gov (United States)

    Carmina, Enrico

    2015-12-01

    Polycystic ovarian syndrome (PCOS) may present with different clinical patterns and the anovulatory phenotype may not be the most common. Data suggest that anovulation in PCOS is not the consequence of increased androgen ovarian secretion but rather of a severe derangement of early follicle development. Other mechanisms may be operative in subgroups of patients and may contribute to the arrest of follicle growth and anovulation. At least 50% of anovulatory patients with PCOS become ovulatory in their late reproductive age. There is also evidence that menopause may occur later in women with PCOS. Finally, a strategy for treatment of infertility in PCOS is presented.

  19. Ovarian cancer and oral contraceptives: collaborative reanalysis of data from 45 epidemiological studies including 23,257 women with ovarian cancer and 87,303 controls

    DEFF Research Database (Denmark)

    Cancer, Collaborative Group on Epidemiological Studies of Ovarian; Beral, V.; Doll, R.;

    2008-01-01

    BACKGROUND: Oral contraceptives were introduced almost 50 years ago, and over 100 million women currently use them. Oral contraceptives can reduce the risk of ovarian cancer, but the eventual public-health effects of this reduction will depend on how long the protection lasts after use ceases. We...... aimed to assess these effects. METHODS: Individual data for 23,257 women with ovarian cancer (cases) and 87,303 without ovarian cancer (controls) from 45 epidemiological studies in 21 countries were checked and analysed centrally. The relative risk of ovarian cancer in relation to oral contraceptive use...... was estimated, stratifying by study, age, parity, and hysterectomy. FINDINGS: Overall 7308 (31%) cases and 32,717 (37%) controls had ever used oral contraceptives, for average durations among users of 4.4 and 5.0 years, respectively. The median year of cancer diagnosis was 1993, when cases were aged an average...

  20. Walter Odington's De etate mundi and the Pursuit of a Scientific Chronology in Medieval England.

    Science.gov (United States)

    Nothaft, Carl Philipp

    2016-01-01

    This article deals with a forgotten treatise on the age of the world, written between 1308 and 1316 by Walter Odington, a monk of Evesham Abbey, otherwise known for his writings on alchemy and music theory. By tracing the sources and rationale behind Odington's arguments and comparing them with those of other medieval authors, the article attempts to shed new light on the state of chronological scholarship in England in the eleventh to fourteenth centuries, when astronomical and astrological methods were freely used to supplement or replace scriptural interpretation, yielding creative and unexpected results. PMID:27320253

  1. [Taking into account both chronology and duration of events is crucial in the medical interview].

    Science.gov (United States)

    Scheen, A J

    2016-03-01

    Medical history taking represents a key step in the diagnostic approach. A structured interview with a special attention to the chronology of events is mandatory. The medical student often fails to use the information on time in an optimal way. The aim of this article is to draw the attention on a few key elements, especially the age of the patient, the duration of symptoms, the time of occurrence of complaints within the 24h period and, finally, how to interpret the simultaneous or sequential occurrence of two (or more) events.

  2. The EDC3 chronology for the EPICA Dome C ice core

    OpenAIRE

    F. Parrenin; Barnola, J.-M.; Beer, J.; T. Blunier; Castellano, E.; Chappellaz, J.; Dreyfus, G.; Fischer, H.; Fujita, S.; J. Jouzel; K. Kawamura; B. Lemieux-Dudon; Loulergue, L.; Masson-Delmotte, V.; Narcisi, B.

    2007-01-01

    The EPICA (European Project for Ice Coring in Antarctica) Dome C drilling in East Antarctica has now been completed to a depth of 3260 m, at only a few meters above bedrock. Here we present the new EDC3 chronology, which is based on the use of 1) a snow accumulation and mechanical flow model, and 2) a set of independent age markers along the core. These are obtained by pattern matching of recorded parameters to either absolutely dated paleoclimatic records, or to insolation variations. We sho...

  3. The EDC3 chronology for the EPICA Dome C ice core

    OpenAIRE

    F. Parrenin; Barnola, J.-M.; Beer, J.; T. Blunier; Castellano, E.; Chappellaz, J.; Dreyfus, G.; Fischer, H.; Fujita, S.; J. Jouzel; K. Kawamura; B. Lemieux-Dudon; Loulergue, L.; Masson-Delmotte, V.; Narcisi, B.

    2007-01-01

    The EPICA (European Project for Ice Coring in Antarctica) Dome C drilling in East Antarctica has now been completed to a depth of 3260 m, at only a few meters above bedrock. Here we present the new EDC3 chronology, which is based on the use of 1) a snow accumulation and mechanical flow model, and 2) a set of independent age markers along the core. These are obtained by pattern matching of recorded parameters to either absolutely dated paleoclimatic records, or to insolation ...

  4. Tubal ligation and salpingectomy and the risk of epithelial ovarian cancer and borderline ovarian tumors

    DEFF Research Database (Denmark)

    Madsen, C; Baandrup, Louise; Dehlendorff, Christian;

    2015-01-01

    OBJECTIVE: According to the recent theories on the ovarian cancer origin, any protective effect of tubal ligation may vary with histologic subtype of ovarian cancer. Furthermore, bilateral salpingectomy may represent an opportunity for surgical prevention of serous ovarian cancer. DESIGN: Nationw......OBJECTIVE: According to the recent theories on the ovarian cancer origin, any protective effect of tubal ligation may vary with histologic subtype of ovarian cancer. Furthermore, bilateral salpingectomy may represent an opportunity for surgical prevention of serous ovarian cancer. DESIGN...

  5. Evolução da aptidão física e capacidade funcional de mulheres ativas acima de 50 anos de idade de acordo com a idade cronológica, na cidade de Santos Evolution of physical fitness and functional capacity in active elderly women over 50 years of age according to chronological age in Santos city

    Directory of Open Access Journals (Sweden)

    José Carlos Lopes Penha

    2012-01-01

    Full Text Available O objetivo deste estudo foi comparar a evolução da aptidão física, capacidade funcional e densidade mineral óssea de mulheres fisicamente ativas durante um ano. Métodos: A amostra consistiu de 78 mulheres de 50 a 79 anos de idade (c: 62,4 ± 7,1 anos, participantes de um programa de exercícios aeróbicos, duas vezes por semana, 50 minutos por sessão durante 3,4 anos e divididas em três grupos: A: 5059 (n: 38; B: 6069 (n: 28; C: 7079 (n:12. Os resultados foram comparados usando ANOVA Two Way com "post-hoc" Bonferroni e delta percentual (*pThe scope of this study was to compare the evolution of physical fitness, functional capacity and bone mineral density in active elderly women over a one-year period. The sample consisted of 78 women from 50 to 79 years of age (c:62.4 ± 7.1 participating in an aerobic program, twice a week, 50 minutes per session during 3.4 years and divided into three age groups: A: 50-59 (n:38; B: 60-69 (n:28; C: 70-79 (n:12. Results were compared using Two Way ANOVA, "post-hoc" Bonferroni and delta (D% variations (*p<.o1. The velocity of rising from a chair and gait speed revealed a significant difference in the three groups ranging from -14.3% to -45.5%; there was a significant improvement in A and B groups in walking speed (-12.1% to -13.9%, and also in maximum gait speed (-15.4% to -18.5%, elbow flexion in all the groups (18.9% to 24.1%, vertical jump (22.5% to 43.9% in groups B and C, and rising from a chair in 30 seconds (25.2% to 30.8% in groups A and B, the flexibility test showed an increase in group A (16.2% to 33.3% and stationary walking in the three groups of (16,4% 30.0% and bone mineral density (BMD presented a significant increase (3.1% to 10.2%. The results indicate the salutary effect of regular physical activity.

  6. Angiosarcoma Arising in an Ovarian Fibroma: A Case Report

    Directory of Open Access Journals (Sweden)

    Eduardo Cambruzzi

    2010-01-01

    Full Text Available Primary ovarian angiosarcoma is a very rare gynaecological sarcoma, with poor prognosis. These tumors are though to arise from carcinosarcomas, teratomas, or the ovarian vasculature and occur at any age. There are only a few cases reported in the international literature, most commonly associated to surface epithelial-stromal or germ cell tumours. Herein, the authors report the clinicopathologic features of an angiosarcoma arising in an ovarian fibroma. A 65-year-old patient was admitted with a palpable mass in the hypogastrium. Grossly, the removed ovary was completely replaced by a solid tumor mass. On histological analysis, the lesion revealed the typical histological features of angiosarcoma with sinusoidal patterns and anaplastic cells, admixed with spindle-shaped cells arranged in fascicles or in a storiform pattern, compatible with a fibroma. The vascular component was strongly immunopositive for CD31 and CD34. The patient was submitted to chemotherapy, and she was alive for two months after surgical proceedings.

  7. Angiosarcoma arising in an ovarian fibroma: a case report.

    Science.gov (United States)

    Cambruzzi, Eduardo; Pegas, Karla Lais; Milani, Daniel Marini; Cruz, Ricardo Pedrini; Guerra, Enilde Heloena; Ferrari, Márcio Balbinotti

    2010-01-01

    Primary ovarian angiosarcoma is a very rare gynaecological sarcoma, with poor prognosis. These tumors are though to arise from carcinosarcomas, teratomas, or the ovarian vasculature and occur at any age. There are only a few cases reported in the international literature, most commonly associated to surface epithelial-stromal or germ cell tumours. Herein, the authors report the clinicopathologic features of an angiosarcoma arising in an ovarian fibroma. A 65-year-old patient was admitted with a palpable mass in the hypogastrium. Grossly, the removed ovary was completely replaced by a solid tumor mass. On histological analysis, the lesion revealed the typical histological features of angiosarcoma with sinusoidal patterns and anaplastic cells, admixed with spindle-shaped cells arranged in fascicles or in a storiform pattern, compatible with a fibroma. The vascular component was strongly immunopositive for CD31 and CD34. The patient was submitted to chemotherapy, and she was alive for two months after surgical proceedings. PMID:21151524

  8. Ovarian actions of resveratrol.

    Science.gov (United States)

    Ortega, Israel; Duleba, Antoni J

    2015-08-01

    Resveratrol, a natural polyphenol found in grapes, berries, and medicinal plants, exhibits antioxidant and anti-inflammatory activities and has been proposed to be a longevity-prolonging agent. There is also growing evidence that resveratrol has cardioprotective properties and beneficial effects on both glucose and lipid metabolism. Recently, several studies have examined the use of resveratrol as a therapeutic agent to treat numerous pathological and metabolic disorders. Herein, we present insights into the mechanisms of action, biological effects, and current evidence of actions of resveratrol on the ovary. In vitro, resveratrol inhibits proliferation and androgen production by theca-interstitial cells. Resveratrol also exerts a cytostatic, but not cytotoxic, effect on granulosa cells, while decreasing aromatization and vascular endothelial growth factor expression. In vivo, resveratrol treatment reduced the size of adipocytes and improved estrus cyclicity in the previously acyclic rat model of polycystic ovary syndrome (PCOS). In addition, resveratrol increased the ovarian follicular reserve and prolonged the ovarian life span in rats. Taken together, resveratrol emerges as a potential therapeutic agent to treat conditions associated with androgen excess, such as PCOS. The efficacy of resveratrol in the treatment of gynecological conditions requires further investigation. PMID:26315293

  9. Analysis of ovarian tumor pathology by Fourier Transform Infrared Spectroscopy

    Directory of Open Access Journals (Sweden)

    Mehrotra Ranjana

    2010-12-01

    Full Text Available Abstract Background Ovarian cancer is the second most common cancer among women and the leading cause of death among gynecologic malignancies. In recent years, infrared (IR spectroscopy has gained attention as a simple and inexpensive method for the biomedical study of several diseases. In the present study infrared spectra of normal and malignant ovarian tissues were recorded in the 650 cm-1 to 4000 cm-1 region. Methods Post surgical tissue samples were taken from the normal and tumor sections of the tissue. Fourier Transform Infrared (FTIR data on twelve cases of ovarian cancer with different grades of malignancy from patients of different age groups were analyzed. Results Significant spectral differences between the normal and the ovarian cancerous tissues were observed. In particular changes in frequency and intensity in the spectral region of protein, nucleic acid and lipid vibrational modes were observed. It was evident that the sample-to-sample or patient-to-patient variations were small and the spectral differences between normal and diseased tissues were reproducible. Conclusion The measured spectroscopic features, which are the spectroscopic fingerprints of the tissues, provided the important differentiating information about the malignant and normal tissues. The findings of this study demonstrate the possible use of infrared spectroscopy in differentiating normal and malignant ovarian tissues.

  10. Oxidatively Modified Proteins in the Serous Subtype of Ovarian Carcinoma

    Directory of Open Access Journals (Sweden)

    Sharifeh Mehrabi

    2014-01-01

    Full Text Available Serous subtype of ovarian cancer is considered to originate from fallopian epithelium mucosa that has been exposed to physiological changes resulting from ovulation. Ovulation influences an increased in inflammation of epithelial ovarian cells as results of constant exposure of cells to ROS. The imbalance between ROS and antioxidant capacities, as well as a disruption of redox signaling, causes a wide range of damage to DNA, proteins, and lipids. This study applied spectrophotometric, dinitrophenylhydrazone (DNPH assay, two-dimensional gel electrophoresis, and Western blot analyses to assess the levels of oxidatively modified proteins in 100 primary serous epithelial ovarian carcinoma and normal/surrounding tissues. These samples were obtained from 56 Caucasian and 44 African-American patients within the age range of 61±10 years. Analyses showed that the levels of reactive protein carbonyl groups increased as stages progressed to malignancy. Additionally, the levels of protein carbonyls in serous ovarian carcinoma among African Americans are 40% (P<0.05 higher relative to Caucasian at similar advanced stages. Results suggest that oxidative stress is involved in the modification of carbonyl protein groups, leading to increased aggressiveness of epithelial ovarian tumors and may contribute to the disease's invasiveness among African Americans.

  11. Prevalence and contribution of BRCA1 mutations in breast cancer and ovarian cancer: Results from three US population-based case-control studies of ovarian cancer

    Energy Technology Data Exchange (ETDEWEB)

    Whittemore, A.S.; Gong, G.; Itnyre, J. [Stanford Univ. School of Medicine, CA (United States)

    1997-03-01

    We investigate the familial risks of cancers of the breast and ovary, using data pooled from three population-based case-control studies of ovarian cancer that were conducted in the United States. We base estimates of the frequency of mutations of BRCA1 (and possibly other genes) on the reported occurrence of breast cancer and ovarian cancer in the mothers and sisters of 922 women with incident ovarian cancer (cases) and in 922 women with no history of ovarian cancer (controls). Segregation analysis and goodness-of-fit testing of genetic models suggest that rare mutations (frequency .0014; 95% confidence interval .0002-.011) account for all the observed aggregation of breast cancer and ovarian cancer in these families. The estimated risk of breast cancer by age 80 years is 73.5% in mutation carriers and 6.8% in noncarriers. The corresponding estimates for ovarian cancer are 27.8% in carriers and 1.8% in noncarriers. For cancer risk in carriers, these estimates are lower than those obtained from families selected for high cancer prevalence. The estimated proportion of all U.S. cancer diagnoses, by age 80 years, that are due to germ-line BRCA1 mutations is 3.0% for breast cancer and 4.4% for ovarian cancer. Aggregation of breast cancer and ovarian cancer was less evident in the families of 169 cases with borderline ovarian cancers than in the families of cases with invasive cancers. Familial aggregation did not differ by the ethnicity of the probands, although the number of non-White and Hispanic cases (N = 99) was sparse. 14 refs., 3 figs., 6 tabs.

  12. Modelling of dead carbon fraction in speleothems: a step towards reliable speleothem 14C-chronologies

    Science.gov (United States)

    Lechleitner, Franziska A.; Jamieson, Robert A.; McIntyre, Cameron; Baldini, Lisa M.; Baldini, James U. L.; Eglinton, Timothy I.

    2015-04-01

    the top 1mm of the stalagmite, using a gas ion source (GIS) on the MICADAS. The resulting DCF-corrected chronology shows that the stalagmite grew over much of the Holocene, and reveals that existing U-Th dates strongly overestimated the real ages and thus are unreliable. In contrast, the new 14C-based chronology, when constrained using trace element ratios and stable isotopes, enables confident reconstruction of broad climatic changes and trends over the Holocene.

  13. Pleural effusion following ovarian hyperstimulation.

    Science.gov (United States)

    Junqueira, Jader Joel Machado; Bammann, Ricardo Helbert; Terra, Ricardo Mingarini; Castro, Ana Cristina P; Ishy, Augusto; Fernandez, Angelo

    2012-01-01

    Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic complication that occurs in the luteal phase of an induced hormonal cycle. In most cases, the symptoms are self-limited and spontaneous regression occurs. However, severe cases are typically accompanied by acute respiratory distress. The objective of the present study was to describe the clinical presentation, treatment, and outcome of pleural effusion associated with OHSS in three patients undergoing in vitro fertilization. The patients ranged in age from 27 to 33 years. The onset of symptomatic pleural effusion (bilateral in all cases) occurred, on average, 43 days (range, 27-60 days) after initiation of hormone therapy for ovulation induction. All three patients required hospitalization for massive fluid resuscitation, and two required noninvasive mechanical ventilation. Although all three patients initially underwent thoracentesis, early recurrence of symptoms and pleural effusion prompted the use of drainage with a pigtail catheter. Despite the high output from the pleural drain (mean, 1,000 mL/day in the first week) and prolonged drainage (for 9-22 days), the outcomes were excellent: all three patients were discharged from hospital. Although pleural effusion secondary to OHSS is probably underdiagnosed, the associated morbidity should not be underestimated, especially because it affects potentially pregnant patients. In this study, early diagnosis and appropriate supportive measures yielded favorable results, limiting the surgical approach to adequate pleural drainage.

  14. Volcano-induced regime shifts in millennial tree-ring chronologies from northeastern North America.

    Science.gov (United States)

    Gennaretti, Fabio; Arseneault, Dominique; Nicault, Antoine; Perreault, Luc; Bégin, Yves

    2014-07-15

    Dated records of ice-cap growth from Arctic Canada recently suggested that a succession of strong volcanic eruptions forced an abrupt onset of the Little Ice Age between A.D. 1275 and 1300 [Miller GH, et al. (2012) Geophys Res Lett 39(2):L02708, 10.1029/2011GL050168]. Although this idea is supported by simulation experiments with general circulation models, additional support from field data are limited. In particular, the Northern Hemisphere network of temperature-sensitive millennial tree-ring chronologies, which principally comprises Eurasian sites, suggests that the strongest eruptions only caused cooling episodes lasting less than about 10 y. Here we present a new network of millennial tree-ring chronologies from the taiga of northeastern North America, which fills a wide gap in the network of the Northern Hemisphere's chronologies suitable for temperature reconstructions and supports the hypothesis that volcanoes triggered both the onset and the coldest episode of the Little Ice Age. Following the well-expressed Medieval Climate Anomaly (approximately A.D. 910-1257), which comprised the warmest decades of the last millennium, our tree-ring-based temperature reconstruction displays an abrupt regime shift toward lower average summer temperatures precisely coinciding with a series of 13th century eruptions centered around the 1257 Samalas event and closely preceding ice-cap expansion in Arctic Canada. Furthermore, the successive 1809 (unknown volcano) and 1815 (Tambora) eruptions triggered a subsequent shift to the coldest 40-y period of the last 1100 y. These results confirm that series of large eruptions may cause region-specific regime shifts in the climate system and that the climate of northeastern North America is especially sensitive to volcanic forcing. PMID:24982132

  15. An Alluvial Surface Chronology Based on Cosmogenic 36Cl Dating, Ajo Mountains (Organ Pipe Cactus National Monument), Southern Arizona

    Science.gov (United States)

    Liu, Beiling; Phillips, Fred M.; Pohl, Molly M.; Sharma, Pankaj

    1996-01-01

    A chronology of alluvial surfaces on piedmont slopes below the western Ajo Mountains, southern Arizona, has been obtained using cosmogenic 36Cl accumulation and AMS radiocarbon dating. The apparent 36Cl ages of individual boulders range from 520,000 to 13,000 yr, and the 14C ages of organic material in the two young terraces are 2750-2350 and 17,800 cal yr B.P. The sequence of 36Cl ages is consistent with the apparent stratigraphic order, but groupings of similar ages for different surfaces appear to result from repeated reworking of older surfaces associated with the deposition of younger ones. The youngest surface gave a distribution of 36Cl ages about 30,000 yr older than the 14C and soil ages; however, this distribution had 36Cl ages that overlapped with 36Cl ages from active channels and hillslopes. We attribute the older-than-expected exposure ages of sampled boulders to inheritance of 36Cl while residing near the surface during very slow erosion on the mountain front. Our results show that although cosmogenic nuclide accumulation can help establish chronologies for surfaces in piedmont settings, care must be used in evaluating the effects of complex exposure histories.

  16. A new chronology for the Dacian Basin (Romania) : Consequences for the kinematic and paleoenvironmental evolution of the Paratethys region

    OpenAIRE

    Vasiliev, I.

    2006-01-01

    This PhD thesis presents new chronostratigraphic results from the Dacian Basin and adjacent regions as part of the Paratethys paleoprovince. In the first three chapters, a new chronology for the Upper Miocene to Pliocene deposits (approximately 8 to 3 Ma) of the Dacian Basin is presented based on high resolution magneto-biostratigraphic data from the Romanian Carpathians foredeep. The new age control permits the calculation of accumulation rates for each polarity zone, which shows a significa...

  17. Genomic profile of ovarian carcinomas

    OpenAIRE

    Micci, Francesca; Haugom, Lisbeth; Vera M. Abeler; Davidson, Ben; Tropé, Claes G; Heim, Sverre

    2014-01-01

    Background It is known that all tumors studied in sufficient number to draw conclusions show characteristic/specific chromosomal rearrangements, and the identification of these chromosomes and the genes rearranged behind the aberrations may ultimately lead to a tailor-made therapy for each cancer patient. Knowledge about the acquired genomic aberrations of ovarian carcinomas is still unsatisfactory. Methods We cytogenetically analyzed 110 new cases of ovarian carcinoma of different histologic...

  18. Ultrasound in evaluating ovarian reserve

    OpenAIRE

    Eman Ahmaed Shawky Sabek; Ola I. Saleh; Howida A. Ahmed

    2015-01-01

    The objective of this study was to compare the diagnostic accuracy of transvaginal ultrasound (TVS), as a less invasive technique instead of hormonal assay to evaluate the ovarian reserve. This study included fifty-five females with breast cancer and we compared the ovarian reserve for these patients by hormonal assay through measuring the serum AntiMullerian Hormone (AMH) level and follicular stimulating hormone (FSH) level before and after chemotherapy, and by transvaginal ultrasound throug...

  19. The origin of ovarian teratomas.

    OpenAIRE

    Parrington, J M; West, L F; Povey, S

    1984-01-01

    Chromosome and enzyme markers have been studied in 21 benign ovarian teratomas from 14 patients. Markers heterozygous in the patient were completely homozygous in 52% of the teratomas and completely heterozygous in 19%. The remainder showed a mixture of the two, 10% having homozygous centromeres with some heterozygous enzyme markers and 19% having heterozygous centromeres and some homozygous enzyme markers. These results suggest that benign ovarian teratomas in the present series arise from g...

  20. Ovarian Abscess Following Therapeutic Insemination

    OpenAIRE

    Kolb, Bradford A.; Lane Mercer; Albert J. Peters; Ralph Kazer

    1994-01-01

    Background: Artificial insemination is a commonly performed procedure for the treatment of various forms of infertility. Infectious complications have only rarely been noted as a complication of intrauterine insemination (IUI). Case: In this presentation, we report the first case of an ovarian abscess following IUI with the husband's semen. Despite treatment with triple antibiotics, an oophorectomy was required. Surgical as well as pathological evaluation confirmed the diagnosis of an ovarian...

  1. Polycystic ovarian syndrome

    Directory of Open Access Journals (Sweden)

    Nina Madnani

    2013-01-01

    Full Text Available Polycystic ovarian syndrome (PCOS is a "multispeciality" disorder suspected in patients with irregular menses and clinical signs of hyperandrogenism such as acne, seborrhoea, hirsutism, irregular menses, infertility, and alopecia. Recently, PCOS has been associated with the metabolic syndrome. Patients may develop obesity, insulin resistance, acanthosis nigricans, Type 2 diabetes, dyslipidemias, hypertension, non-alcoholic liver disease, and obstructive sleep apnoea. Good clinical examination with hematological and radiological investigations is required for clinical evaluation. Management is a combined effort involving a dermatologist, endocrinologist, gynecologist, and nutritionist. Morbidity in addition includes a low "self image" and poor quality of life. Long term medications and lifestyle changes are essential for a successful outcome. This article focuses on understanding the normal and abnormal endocrine functions involved in the pathogenesis of PCOS. Proper diagnosis and management of the patient is discussed.

  2. Tamoxifen and ovarian function.

    Directory of Open Access Journals (Sweden)

    Martine Berliere

    Full Text Available BACKGROUND: Some studies suggest that the clinical parameter "amenorrhea" is insufficient to define the menopausal status of women treated with chemotherapy or tamoxifen. In this study, we investigated and compared the ovarian function defined either by clinical or biological parameters in pre-menopausal breast cancer patients treated with tamoxifen administered as adjuvant therapy. MATERIALS AND METHODS: Between 1999 and 2003, 138 premenopausal patients consecutively treated for early breast cancer were included. Sixty-eight received tamoxifen in monotherapy as the only adjuvant systemic treatment (Group I and 70 were treated with tamoxifen after adjuvant chemotherapy (Group II. All patients had a confirmed premenopausal status based on clinical parameters and hormonal values at study entry. They were followed prospectively every 3 months for 3 years: menses data, physical examination and blood tests (LH, FSH, 17-beta-estradiol. Vaginal ultrasonography was carried out every 6 months. After 3 years, prospective evaluation was completed and monitoring of ovarian function was performed as usual in our institution (1x/year. All data were retrospectively evaluated in 2011. RESULTS: Three patients were excluded from the study in group I and 2 were excluded in group II. Patients were divided into 4 subgroups according to clinical data, i.e. menses patterns. These patterns were assessed by questionnaires. a: Regular menses (>10 cycles/year b: Oligomenorrhea (5 to 9 cycles/year c: Severe oligomenorrhea (1 to 4 cycles/year d: Complete amenorrhea Estrogen levels did not appear to have any impact on disease-free survival rates after 3 or 8 years. FSH values were also documented and analyzed. They exhibited the same profile as estradiol values. CONCLUSIONS: Amenorrhea is an insufficient parameter to define menopausal status in patients receiving tamoxifen. Low estradiol levels must be coupled with other biological parameters to characterize endocrine status

  3. Doxorubicin-induced ovarian toxicity

    Directory of Open Access Journals (Sweden)

    Rizel Shulamith

    2010-03-01

    Full Text Available Abstract Background Young cancer patients may occasionally face infertility and premature gonadal failure. Apart from its direct effect on follicles and oocytes, chemotherapy may induce ovarian toxicity via an impact on the entire ovary. The role of doxorubicin in potential ovarian failure remains obscure. Our intention was to elucidate doxorubicin-related toxicity within ovaries. Methods Female mice were injected intraperitoneally with 7.5 or 10 mg/kg doxorubicin and their ovaries were visualized in vivo by high resolution MRI, one day and one month following treatment. Ovaries of other treated mice were excised and weighed at the same post-treatment intervals. Ovarian histological sections were stained for TUNEL or active caspase-3 and follicles were counted and categorized. Ovulation rates were evaluated in superovulated female mice treated with doxorubicin. Results A single injection of doxorubicin resulted in a major reduction in both ovarian size and weight that lasted even one month post treatment. A dramatic reduction in ovulation rate was observed one week after treatment, followed by a partial recovery at one month. Histological examination revealed positive staining of TUNEL and active caspase-3. We observed a significant reduction in the population of secondary and primordial follicles one month following treatment. Conclusions Our results may imply a mechanism of chemotherapy-induced ovarian toxicity, manifested by reduced ovulation and accompanied by a reduction in ovarian size, caused probably by an acute insult to the ovary.

  4. AFSC/REFM: Bomb-produced age validation study

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Fish age validation with bomb-produced radiocarbon (14C) requires a known-age Delta14C reference chronology spanning the era of a marine increase in bomb-produced...

  5. Chronological History of Federal Fleet Actions and Mandates (Brochure)

    Energy Technology Data Exchange (ETDEWEB)

    2011-04-01

    This chronological history of Federal fleet actions and mandates provides a year-by-year timeline of the acts, amendments, executive orders, and other regulations that affect Federal fleets. The fleet actions and mandates included in the timeline span from 1988 to 2009.

  6. Nurturing Children's Concepts of Time and Chronology through Literature

    Science.gov (United States)

    Harms, Jeanne McLain; Lettow, Lucille J.

    2007-01-01

    Time is an emerging concept during childhood. At first, children's concept of time is rather vague. Banks and Banks suggest that the goal for teaching time concepts and chronology in the elementary and middle school years should be to nurture students' ability to understand and interpret time concepts and comprehend how past and present events are…

  7. Potential radiocarbon chronology tool using archaeal tetraether lipids for the western Arctic Ocean sediment

    Science.gov (United States)

    Uchida, M.; Kondo, M.; Utsumi, M.; Shibata, Y.

    2011-12-01

    The Arctic Ocean plays a major role in global climate changes by changing global energy balance through ice-albedo feedback and by affecting the oceanic thermohaline circulation through the water exchange with the Atlantic and Pacific Ocean. For future prediction of those changes in Arctic Ocean it is necessary to reconstruct details of past climate history with accurate age model. However, it is not easy to make age model of sediment cores covering late Pleistocene-Holocene transition including global abrupt climate change because preservation of carbonate fossil such as planktonic foraminifera is very limited. In the glacial time, foraminifera is almost barren. Thus, so far climate history in the Arctic Ocean environment is poorly understood. For these reasons, we are looking for alternative chronological target instead of foraminifera. In this study, radiocarbon contents of archaeal glycerol dibiphytanyl glycerol tetraether lipids (GDGTs) from Arctic surface sediments, which is also used for paleothermometry, were measured and compared with those of dissolved inorganic carbon (DIC) of sea water, planktonic and benthic foraminifera, shell, and bulk organic matter in the same horizons. We will discuss potential as chronology using the GDGTs and carbon sources of these compounds.

  8. Yeast MRX deletions have short chronological life span and more triacylglycerols.

    Science.gov (United States)

    Kanagavijayan, Dhanabalan; Rajasekharan, Ram; Srinivasan, Malathi

    2016-02-01

    Saccharomyces cerevisiae is an excellent model organism for lipid research. Here, we have used yeast haploid RAdiation Damage (RAD) deletion strains to study life span and lipid storage patterns. RAD genes are mainly involved in DNA repair mechanism and hence, their deletions have resulted in shorter life span. Viable RAD mutants were screened for non-polar lipid content, and some of the mutants showed significantly high amounts of triacylglycerol (TAG) and steryl ester, besides short chronological life span. Among these, RAD50, MRE11 and XRS2 form a complex, MRX that is involved in homologous recombination that showed an increase in the amount of TAG. Microarray data of single MRX deletions revealed that besides DNA damage signature genes, lipid metabolism genes are also differentially expressed. Lipid biosynthetic genes (LPP1, SLC1) were upregulated and lipid hydrolytic gene (TGL3) was downregulated. We observed that rad50Δ, mre11Δ, xrs2Δ and mrxΔ strains have high number of lipid droplets (LDs) with fragmented mitochondria. These mutants have a short chronological life span compared to wild type. Aged wild-type cells also accumulated TAG with LDs of ∼2.0 μm in diameter. These results suggest that TAG accumulation and big size LDs could be possible markers for premature or normal aging. PMID:26678749

  9. Pelvic inflammatory disease and risk of invasive ovarian cancer and ovarian borderline tumors

    DEFF Research Database (Denmark)

    Rasmussen, Christina B; Faber, Mette T; Jensen, Allan;

    2013-01-01

    The aim of the study was to examine the potential association between a history of pelvic inflammatory disease (PID) and risk of epithelial ovarian cancer or ovarian borderline tumors.......The aim of the study was to examine the potential association between a history of pelvic inflammatory disease (PID) and risk of epithelial ovarian cancer or ovarian borderline tumors....

  10. Survivorship Care Planning in Improving Quality of Life in Survivors of Ovarian Cancer

    Science.gov (United States)

    2016-08-19

    Cancer Survivor; Stage IA Ovarian Epithelial Cancer; Stage IB Ovarian Epithelial Cancer; Stage IC Ovarian Epithelial Cancer; Stage IIA Ovarian Epithelial Cancer; Stage IIB Ovarian Epithelial Cancer; Stage IIC Ovarian Epithelial Cancer; Stage IIIA Ovarian Epithelial Cancer; Stage IIIB Ovarian Epithelial Cancer; Stage IIIC Ovarian Epithelial Cancer

  11. An epidemiologic risk prediction model for ovarian cancer in Europe : The EPIC study

    OpenAIRE

    Li, K; Huesing, A.; Fortner, R. T.; Tjonneland, A.; Hansen, L.; Dossus, L; Chang-Claude, J; Bergmann, M.; A. Steffen; Bamia, C.; Trichopoulos, D; Trichopoulou, A; Palli, D; Mattiello, A; Agnoli, C

    2015-01-01

    Background: Ovarian cancer has a high case-fatality ratio, largely due to late diagnosis. Epidemiologic risk prediction models could help identify women at increased risk who may benefit from targeted prevention measures, such as screening or chemopreventive agents. Methods: We built an ovarian cancer risk prediction model with epidemiologic risk factors from 202 206 women in the European Prospective Investigation into Cancer and Nutrition study. Results: Older age at menopause, longer durati...

  12. PATTERN OF OVARIAN NEOPLASM IN RURAL POPULATION: A FIVE YEAR STUDY FROM TERTIARY CARE HOSPITAL

    OpenAIRE

    Umesh

    2014-01-01

    OBJECTIVE : The aim of the study was to know the morphological pattern of benign and malignant ovarian neoplasms and their distribution in different age groups in rural population of India. MATERIAL AND METHODS : A retrospective study of all cases of ovarian neoplasms diagnosed at department of pathology, Maharaja Medical College, Agroha during period of five year (Aug, 07 — Oct.12) was done. The tumors were classified according to WHO classification after thorou...

  13. Developmental programming: Impact of prenatal testosterone treatment and postnatal obesity on ovarian follicular dynamics

    OpenAIRE

    V. Padmanabhan; Smith, P.; Veiga-Lopez, A.

    2012-01-01

    Prenatal testosterone (T) excess leads to reproductive dysfunctions in sheep with obesity exaggerating such defects. Developmental studies found ovarian reserve is similar in control and prenatal T sheep at fetal day 140, with prenatal T females showing increased follicular recruitment and persistence at 10 months of age (postpubertal). This study tested if prenatal T sheep show accelerated depletion prepubertally and if depletion of ovarian reserve would explain loss of cyclicity in prenatal...

  14. The role of selected molecular pathways in the pathogenesis of ovarian teratomas

    OpenAIRE

    Jarosław Bal; Marian Stanisław Gabryś; Irena Jałocha

    2009-01-01

    From the research point of view, –ovarian teratomas, especially mature ones, are an interesting group of germ-cell tumors of the ovary. The WHO classification, which is not simple but includes all tumors that arise from germ cells, emphasizes the complexity of this group. Their complex pathophysiology is also very interesting from the clinical point of view because of their frequent occurrence, especially among young women of reproductive age. Mature ovarian teratomas are benign germ-cell tum...

  15. Mathematical models of breast and ovarian cancers.

    Science.gov (United States)

    Botesteanu, Dana-Adriana; Lipkowitz, Stanley; Lee, Jung-Min; Levy, Doron

    2016-07-01

    Women constitute the majority of the aging United States (US) population, and this has substantial implications on cancer population patterns and management practices. Breast cancer is the most common women's malignancy, while ovarian cancer is the most fatal gynecological malignancy in the US. In this review, we focus on these subsets of women's cancers, seen more commonly in postmenopausal and elderly women. In order to systematically investigate the complexity of cancer progression and response to treatment in breast and ovarian malignancies, we assert that integrated mathematical modeling frameworks viewed from a systems biology perspective are needed. Such integrated frameworks could offer innovative contributions to the clinical women's cancers community, as answers to clinical questions cannot always be reached with contemporary clinical and experimental tools. Here, we recapitulate clinically known data regarding the progression and treatment of the breast and ovarian cancers. We compare and contrast the two malignancies whenever possible in order to emphasize areas where substantial contributions could be made by clinically inspired and validated mathematical modeling. We show how current paradigms in the mathematical oncology community focusing on the two malignancies do not make comprehensive use of, nor substantially reflect existing clinical data, and we highlight the modeling areas in most critical need of clinical data integration. We emphasize that the primary goal of any mathematical study of women's cancers should be to address clinically relevant questions. WIREs Syst Biol Med 2016, 8:337-362. doi: 10.1002/wsbm.1343 For further resources related to this article, please visit the WIREs website. PMID:27259061

  16. Modern Approach in Premature Ovarian Failure

    Directory of Open Access Journals (Sweden)

    Pacu Irina

    2014-09-01

    Full Text Available Premature ovarian failure (POF is a condition affecting 1-2% of women younger than 40 years of age, characterized by amenorrhea, hypoestrogenism and elevated gonadotropin levels. In the last years it became a problem of social health interest as the frequency increased due to environmental factors and new, efficient methods for cancer treatment in young women. Few genes have beed identified to explain cases of POF but there are also autoimmune associated conditions and an increasing number of iatrogenic cases (chemotherapy, surgery, radiotherapy. Modern approach in POF means not only a precise etiological diagnosis, but also a correct counseling for these patients who often want to become parents, and a chance for a healthy life without the long term consequences of estrogen deprivation from an early age. In vitro fertilization (IVF techniques can be useful for certain cases but research is needed on strategies to improve fertility for women who have follicles remaining in the ovaries.

  17. Exercise May Help Thwart Ovarian Cancer

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_159486.html Exercise May Help Thwart Ovarian Cancer Chronic inactivity linked ... TUESDAY, June 21, 2016 (HealthDay News) -- Lack of exercise is associated with an increased risk of ovarian ...

  18. A query on the year of King Wu's conquest over King Zhou determined by the Xia- Shang-Zhou Chronology Project ——Materials finding and astronomical methods for chronological studies of China

    Institute of Scientific and Technical Information of China (English)

    李勇

    2003-01-01

    This paper reviews the studies on the event that King Wu of the Western Zhou Dynasty defeated King Zhou of the late Shang Dynasty, an important historical event in Chinese history, and questions on the year in which this event took place determined by researchers of the Xia-Shang-Zhou Chronology Project of China in 2000. This paper also discusses on how to obtain primordial materials and how to use astronomical methods in the chronological studies of Chinese history. With both the new astronomical methods (the Moon Age Calendar Method and the Direct Solving Method) and the calculation based on the confirmed real-time materials, especially scriptures on oracle bones and bronze vessels, this paper obtains a more accurate and reliable result, putting the event at BC 1040 to BC 1030.

  19. Genetic analysis of ovarian microcystic stromal tumor

    OpenAIRE

    Lee, Jae Hoon; Kim, Hyun-Soo; Cho, Nam Hoon; Lee, Jung-Yun; Kim, Sunghoon; Kim, Sang Wun; Kim, Young Tae; Nam, Eun Ji

    2016-01-01

    Microcystic stromal tumor (MCST) of the ovary is a rare subtype of ovarian tumor first described in 2009. Although high nuclear expression of β-catenin and β-catenin gene (CTNNB1) mutation are related with ovarian MCST, the origin and genetic background of ovarian MCST remain unclear. In this study, two cases of ovarian MCST are presented. Microscopically, the tumors showed a microcystic pattern and regions with lobulated cellular masses with intervening hyalinized, fibrous stroma. Tumor cell...

  20. Unique Case Reports Associated with Ovarian Failure: Necessity of Two Intact X Chromosomes

    Directory of Open Access Journals (Sweden)

    Lakshmi Rao Kandukuri

    2012-01-01

    Full Text Available Premature ovarian failure is defined as the loss of functional follicles below the age of 40 years and the incidence of this abnormality is 0.1% among the 30–40 years age group. Unexplained POF is clinically recognized as amenorrhoea (>6 months with low level of oestrogen and raised level of Luteinizing Hormone (LH and Follicle Stimulating Hormone (FSH > 20 IU/l occurring before the age of 40. It has been studied earlier that chromosomal defects can impair ovarian development and its function. Since there is paucity of data on chromosomal defects in Indian women, an attempt is made to carry out cytogenetic evaluation in patients with ovarian failure. Cytogenetic analysis of women with ovarian defects revealed the chromosome abnormalities to be associated with 14% of the cases analyzed. Interestingly, majority of the abnormalities involved the X-chromosome and we report two unique abnormalities, (46,XXdel(Xq21-22 and q28 and (mos,45XO/46,X+ringX involving X chromosome in association with ovarian failure. This study revealed novel X chromosome abnormalities associated with ovarian defects and these observations would be helpful in genetic counseling and apart from, infertility clinics using the information to decide suitable strategies to help such patients.

  1. Epidemiology of epithelial ovarian cancer, a single institution-based study in India

    Directory of Open Access Journals (Sweden)

    Surendra Kumar Saini

    2016-01-01

    Full Text Available Background: Ovarian cancer is the leading cause of mortality among all cancers of female genital tract in countries where effective cervical cancer screening program exists. As the world's population ages, remarkable increase in the total number of ovarian cancer cases are expected. This is preliminary epidemiological study to decide priorities in ovarian cancer research. Materials and Methods: A retrospective study was conducted with primary epithelial ovarian cancer cases registered in J. K. Cancer Institute, Kanpur (Uttar Pradesh, from 2007 to 2009. Patients' age at diagnosis, clinical feature, parity of patients, tumor histological type, Federation of Gynecology and Obstetrics stage, chemotherapy regimens, and overall survival data were collected and analyzed. Results: One hundred and sixty-three cases of primary ovarian epithelial cancer were analyzed. Patients' mean age at diagnosis was 55.98 ± 9.24 (median = 55. Serous adenocarcinoma (49.69% was the most prevalent type of histopathology followed by endometroid (19.1%, mucinous (10.42% and clear cell (4.29%. Combination of taxane and platin was most commonly used first line regimen in newly diagnosed as well as in relapsed patients post 1 year. Survival was not significantly different in various histopathology (log-rank P = 0.7406, but advancing stage demonstrated gradually poor survival (log-rank P < 0.05 when compared with early stage disease. Conclusion: Research efforts should be in the direction to find early diagnostic and effective screening tools as well as better therapeutic approaches for advanced epithelial ovarian cancer.

  2. Precipitation reconstruction using ring-width chronology of Himalayan cedar from western Himalaya: Preliminary results

    Indian Academy of Sciences (India)

    Ram R Yadav; Won-Kyu Park

    2000-09-01

    Himalayan cedar (Cedrus deodara (D. Don) G. Don) due to its long age and wide ecological amplitude in the Himalayan region has strong dendroclimatic potential. A well replicated ring-width chronology of it, derived from the ensemble of tree-ring samples of two adjacent homogeneous sites, has been used to reconstruct precipitation for the non-monsoon months (previous year October to concurrent May) back to AD 1171. This provides the first record of hydrological conditions for the western Himalayan region, India during the whole of the `Little Ice Age' and latter part of the `Medieval Warm Period'. The reconstruction revealed the wettest and the driest non-monsoon months during the fourteenth and the thirteenth centuries, respectively. The seventeenth century consistently recorded dry non-monsoon months in the western Himalayan region. Surplus precipitation, especially more pronounced since the 1950s, is recorded in the current century.

  3. Anti-Mullerian hormone and ovarian dysfunction

    NARCIS (Netherlands)

    Broekmans, Frank J.; Visser, Jenny A.; Laven, Joop S. E.; Broer, Simone L.; Themmen, Axel P. N.; Fauser, Bart C.

    2008-01-01

    Anti-Mullerian hormone (AMH) has important roles in postnatal ovarian function. Produced by ovarian granulosa cells, AMH is involved in initial follicle development. In fact, serum AMH level correlates with ovarian follicle number. In patients with polycystic ovary syndrome (PCOS), AMH levels are el

  4. A retrospective study of ovarian cysts

    Directory of Open Access Journals (Sweden)

    Shivaji Neelgund

    2016-06-01

    Conclusions: Unilocular simple ovarian cysts are usually functional ovarian cysts and resolve spontaneously. Therapy by 3 to 6 months of Oral Contraceptives, usually resolves them and this also helps to distinguish between physiological and pathological ovarian cysts [Int J Reprod Contracept Obstet Gynecol 2016; 5(6.000: 1969-1973

  5. Do We Know What Causes Ovarian Cancer?

    Science.gov (United States)

    ... Next Topic Can ovarian cancer be prevented? Do we know what causes ovarian cancer? We don’t yet know exactly what causes most ovarian cancers. As discussed in the previous section, we do know some factors that make a woman ...

  6. Ovarian teratoma and endometritis in a mare

    Science.gov (United States)

    2005-01-01

    Abstract An 8-year-old Arabian mare was admitted for a large ovarian anovulatory follicle. A clinical diagnosis of ovarian tumor and endometritis was established. Histological examinations revealed an ovarian teratoma and a grade II endometritis. Three months after unilateral ovariectomy, the mare was confirmed pregnant and eventually gave birth uneventfully. PMID:16363331

  7. Acute abdomen in early pregnancy caused by torsion of bilateral huge multiloculated ovarian cysts

    Directory of Open Access Journals (Sweden)

    Sathiyakala Rajendran

    2015-10-01

    Full Text Available The association of pregnancy and torsion of bilateral huge benign ovarian cyst is rare. We report a case of multigravida at 13 weeks of pregnancy presenting with acute onset of lower abdominal pain. Ultrasound revealed bilateral multiloculated ovarian cysts of size 10x10 cm on right side and 15x10cm on left side with evidence of torsion and a single live intrauterine fetus of gestational age 13 weeks 4 days. Emergency laparotomy was done with vaginal susten 200 mg as perioperative tocolysis. Intra operatively, uterus was enlarged to 14 weeks size. Both ovaries were replaced with multiloculated cysts of size 15x10 cm on left side and 10x10 cm on right side. Ovarian pedicle was found to be twisted once on right side and twice on left side. On right side, untwisting of pedicle was done and the ovarian cyst was punctured at multiple sites to drain the clear fluid. Biopsy was taken from the right ovarian cyst wall. On left side, ovariotomy was done. Histopathology revealed mucinous cyst adenoma of left ovary and multiple corpus luteum in right ovarian biopsy specimen. The patient was followed up with regular antenatal check-ups and ultrasound to rule out the recurrence of ovarian cyst on right side. The patient successfully delivered a term male baby at 39 weeks. [Int J Reprod Contracept Obstet Gynecol 2015; 4(5.000: 1598-1601

  8. Mid-Late Pleistocene OSL chronology in western Amazonia and implications for the transcontinental Amazon pathway

    Science.gov (United States)

    Rossetti, Dilce F.; Cohen, Marcelo C. L.; Tatumi, Sonia H.; Sawakuchi, André O.; Cremon, Édipo H.; Mittani, Juan C. R.; Bertani, Thiago C.; Munita, Casimiro J. A. S.; Tudela, Diego R. G.; Yee, Márcio; Moya, Gabriela

    2015-12-01

    The origin of the transcontinental Amazon drainage system remains unrevealed. Sedimentary deposits formed from the Neogene in the Amazonas and Solimões Basins constitute natural archives for reconstructing this event in space and time. However, paleoenvironmental and chronological analyses focusing on these deposits, or even their basic mapping, are still scarce to allow such investigation. In this context, primary interests are fluvial strata related to the lithostratigraphic Içá Formation, mapped over a widespread area in western Amazonian lowlands. Although long regarded as Plio-Pleistocene in age, this unit has not yet been dated and its overall depositional setting remains largely undescribed. The main goal of the present work is to contribute for improving facies analysis and chronology of these deposits, approaching an area in southwestern Amazonia and another in northern Amazonia, which are located more than 1000 km apart. Despite this great distance, the sedimentological and chronological characteristics of deposits from these two areas are analogous. Hence, facies analysis revealed paleoenvironments including active channel, abandoned channel, point bar, crevasse splay and floodplain, which are altogether compatible with meandering fluvial systems. Similarly, optically stimulated luminescence (OSL) dating revealed thirty three ages ranging from 65.4 ± 16.9 to 219.6 ± 25.1 ky (in addition to three outliners of 54.0 ± 7.6, 337.3 ± 36.9 and 346.6 ± 48.6 ky), and nine 97.1 ± 9.9 to 254.8 ± 23.8 ky for the areas in southwestern and northern Amazonia, respectively. These data lead to establish that deposits mapped as Içá Formation over a vast area of western Brazilian Amazonia have a Mid-Late Pleistocene age, rather than the previously inferred Plio-Pleistocene age. It follows that if Plio-Pleistocene deposits exist in this region they remain to be dated and must be restricted to a narrow belt in western Amazonia, as well as isolated occurrences

  9. The Antral Follicle Count Predicts the Outcome of Pregnancy in a Controlled Ovarian Hyperstimulation/Intrauterine Insemination Program

    OpenAIRE

    Chang, Ming-Yang; Chiang, Chi-Hsin; Chiu, Tsung-Hong; Hsieh, T'sang-T'ang; Soong, Yung-Kuei

    1998-01-01

    Purpose:Our purpose was to test whether age-related changes in antral follicle counts can predict the pregnancy outcome in the early follicular phase of a controlled ovarian hyperstimulation/intrauterine insemination (COH/IUI) program.

  10. Adolescent ovarian masses: A retrospective analysis.

    Science.gov (United States)

    Gupta, Bindiya; Guleria, Kiran; Suneja, Amita; Vaid, Neelam B; Rajaram, Shalini; Wadhwa, Neelam

    2016-05-01

    A retrospective study was conducted to review incidence, clinical practice, surgical management and histology of adolescent ovarian masses in order to audit and improve future practices. Complete hospital records of all adolescents between 10 and 20 years who had undergone surgery for ovarian masses were analysed between November 2006 to 2014. Parameters analysed were age, clinical features, diagnosis, operative procedure and histopathology. Ninety-four patients were included in the study and among them, 37 had non-neoplastic masses, 30 had benign neoplasms while 27 had malignant tumors. The main clinical presentations were abdominal pain (54%) and abdominal mass (41%). Dermoid was the most common benign neoplasm while germ cell tumor was the most common malignant mass; dysgerminoma being the commonest (68%). Malignancy was more common in early adolescence (12 ± 4.8 years) while non-neoplastic masses were seen more frequently in late adolescence (17.7 ± 2.2 years). There was a fair correlation between ultrasound and histopathological diagnosis. PMID:26789784

  11. New radiocarbon chronology of a late Holocene landslide event in the Mont Blanc massif, Italy

    Science.gov (United States)

    Hajdas, Irka; Sojc, Ursula; Ivy-Ochs, Susan; Akçar, Naki; Deline, Philip

    2016-04-01

    The Ferret valley Arp Nouva peat bog located in the Mont Blanc massif was critically evaluated since previously published radiocarbon dates have led to controversial conclusions on the formation of the swamp. Radiocarbon dating of roots from three pits of up to 1 m depth was applied to discuss the question whether the historical documented rock avalanche occurring in AD 1717 overran the peat bog or formed it at a later stage. Our results indicate that the rock avalanche formed the Arp Nouva peat bog by downstream blockage of the Bellecombe torrent. Furthermore, careful sample preparation with consequent separation of roots from the bulk peat sample provides possible explanation for the too old 14C ages of bulk peat samples dated previously (Deline and Kirkbride, 2009 and references therein). This work demonstrates that a combined geomorphological and geochronological approach is the most reliable way to reconstruct landscape evolution, especially in light of apparent chronological problems. The key to successful 14C dating is a careful sample selection and the identification of material that might be not ideal for chronological reconstructions. References Deline, Philip, and Martin P. Kirkbride. "Rock avalanches on a glacier and morainic complex in Haut Val Ferret (Mont Blanc Massif, Italy)".Geomorphology 103 (2009): 80-92.

  12. A Survey of the Xia-Shang-Zhou Chronology Project

    Institute of Scientific and Technical Information of China (English)

    Xi Zezong

    2002-01-01

    @@ Ⅰ. Goals In connection with the history of science, the XiaShang-Zhou Chronology Project is one of the important projects of the National Key Science and Technology Research and Development Programme of the Ninth Five-Year Plan. It officially began in May 1996.After five years of effort by more than 200 scholars and experts from the Chinese Academy of Sciences,the Chinese Academy of Social Sciences, Peking University and other institutions, the project has attained its goal. The general goal of the project is to establish a chronological table for the three dynasties by means of combining the humanities and social sciences with the natural sciences. The concrete goals for different historical periods are:

  13. Energy history chronology from World War II to the present

    Energy Technology Data Exchange (ETDEWEB)

    Dean, P.C.

    1982-08-01

    This report provides a basic guide to the major Presidential, Legislative, Judicial, and Federal agency actions relating to energy policy, research, development, and regulation in recent years. The chronology is arranged synoptically, allowing users to reference easily the historical context in which each event occurred. Summaries of Presidential, Legislative, and Judicial actions relating to energy, rosters of federal energy officials, and a genealogy of federal energy agencies are also provided in separate appendices. The Energy History Chronology was prepared in conjunction with the History Division's series of pamphlets on the Institutional Origins of the Department of Energy. The series includes concise histories of the Department of Energy, the Energy Research and Development Administration, the Federal Energy Administration, and the Atomic Energy Commission. All significant events and achievements noted in the institutional history are also listed.

  14. Chronology protection in stationary three-dimensional spacetimes

    CERN Document Server

    Raeymaekers, Joris

    2011-01-01

    We study chronology protection in stationary, rotationally symmetric spacetimes in 2+1 dimensional gravity, focusing especially on the case of negative cosmological constant. We show that in such spacetimes closed timelike curves must either run all the way to the boundary or, alternatively, the matter stress tensor must violate the null energy condition in the bulk. We also show that the matter in the closed timelike curve region gives a negative contribution to the conformal weight from the point of view of the dual conformal field theory. We illustrate these properties in a class of examples involving rotating dust in anti-de Sitter space, and comment on the use of the AdS/CFT correspondence to study chronology protection.

  15. Molecular imaging in ovarian cancer.

    Science.gov (United States)

    Reyners, A K L; Broekman, K E; Glaudemans, A W J M; Brouwers, A H; Arts, H J G; van der Zee, A G J; de Vries, E G E; Jalving, M

    2016-04-01

    Ovarian cancer has a high mortality and novel-targeted treatment strategies have not resulted in breakthroughs for this disease. Insight into the molecular characteristics of ovarian tumors may improve diagnosis and selection of patients for treatment with targeted therapies. A potential way to achieve this is by means of molecular imaging. Generic tumor processes, such as glucose metabolism ((18)F-fluorodeoxyglucose) and DNA synthesis ((18)F-fluorodeoxythymidine), can be visualized non-invasively. More specific targets, such as hormone receptors, growth factor receptors, growth factors and targets of immunotherapy, can also be visualized. Molecular imaging can capture data on intra-patient tumor heterogeneity and is of potential value for individualized, target-guided treatment selection. Early changes in molecular characteristics during therapy may serve as early predictors of response. In this review, we describe the current knowledge on molecular imaging in the diagnosis and as an upfront or early predictive biomarker in patients with ovarian cancer. PMID:27141066

  16. Testosterone for Poor Ovarian Responders

    DEFF Research Database (Denmark)

    Polyzos, Nikolaos P; Davis, Susan R; Drakopoulos, Panagiotis;

    2016-01-01

    Testosterone, an androgen that directly binds to the androgen receptor, has been shown in previous small randomized controlled trials to increase the reproductive outcomes of poor ovarian responders. In most of these studies, transdermal testosterone in relatively high doses was administered before...... ovarian stimulation with a duration varying from 5 to 21 days. Nevertheless, the key question to be asked is whether, based on ovarian physiology and testosterone pharmacokinetics, a short course of testosterone administration of more than 10 mg could be expected to have any beneficial effect...... on reproductive outcome. The rationale for asking this question lies in the existing scientific evidence derived from basic research and animal studies regarding the action of androgens during folliculogenesis, showing that their main effect in follicular development is defined during the earlier developmental...

  17. An immunological insight into premature ovarian failure (POF).

    Science.gov (United States)

    Dragojević-Dikić, Svetlana; Marisavljević, Dragomir; Mitrović, Ana; Dikić, Srdjan; Jovanović, Tomislav; Janković-Raznatović, Svetlana

    2010-09-01

    Premature ovarian failure (POF), a serious life-changing condition that affects young women, remains an enigma and the researchers' challenge. The term POF generally describes a syndrome of gonadal failure before the age of 40, characterized by amenorrhea, sex steroid deficiency and elevated levels of gonadotropins. Infertility and psychological stress are common consequences of this entity the prevalence of which is 0.9-3%. The known cause of this condition includes: genetic aberrations, autoimmune ovarian damage, iatrogenic and environmental factors, although in majority of cases the underlying cause is not identified. For many women in whom the cause of ovarian failure is unknown, autoimmunity may be the pathogenic mechanism. There is currently evidence that some cases of POF are due to faulty recognition of self in the ovary by the immune system, possibly provoked by genetic or environmental factors initiating such immune response. Numerous evidence, including association with multiple autoimmune endocrine disorders, clinical reversibility, transitory estrogen deficiency, histological and immunological features and the demonstration of circulating ovarian antibodies in serum samples from women with POF, have suggested its immunological origin. We discuss the possible role of such an autoimmune process as a cause or consequence of POF including treatment strategies in POF patients.

  18. Adolescent Premature Ovarian Insufficiency Following Human Papillomavirus Vaccination

    Directory of Open Access Journals (Sweden)

    Deirdre Therese Little MBBS, DRANZCOG, FACRRM

    2014-10-01

    Full Text Available Three young women who developed premature ovarian insufficiency following quadrivalent human papillomavirus (HPV vaccination presented to a general practitioner in rural New South Wales, Australia. The unrelated girls were aged 16, 16, and 18 years at diagnosis. Each had received HPV vaccinations prior to the onset of ovarian decline. Vaccinations had been administered in different regions of the state of New South Wales and the 3 girls lived in different towns in that state. Each had been prescribed the oral contraceptive pill to treat menstrual cycle abnormalities prior to investigation and diagnosis. Vaccine research does not present an ovary histology report of tested rats but does present a testicular histology report. Enduring ovarian capacity and duration of function following vaccination is unresearched in preclinical studies, clinical and postlicensure studies. Postmarketing surveillance does not accurately represent diagnoses in adverse event notifications and can neither represent unnotified cases nor compare incident statistics with vaccine course administration rates. The potential significance of a case series of adolescents with idiopathic premature ovarian insufficiency following HPV vaccination presenting to a general practice warrants further research. Preservation of reproductive health is a primary concern in the recipient target group. Since this group includes all prepubertal and pubertal young women, demonstration of ongoing, uncompromised safety for the ovary is urgently required. This matter needs to be resolved for the purposes of population health and public vaccine confidence.

  19. REVIEW: South & East Asian Adult Education: Chronologies in Commonwealth Countries

    OpenAIRE

    SHARMA, Reviewed By Dr. Ramesh C.

    2002-01-01

    The major aim of this international research project was to record and analyze the chronological development of adult education in the country members of the commonwealth. It traces the developments in the area of adult education since early 1900s to the very latest as for 1999. This project was supported by the Commonwealth of Learning; the Ontario Institute for Studies in Education, University of Toronto; the Commonwealth Association for the Education and Training of Adults; and the United ...

  20. Asbestos: a chronology of its origins and health effects.

    OpenAIRE

    Huncharek, M

    1990-01-01

    The emotionalised subject of asbestos is treated in chronological terms: how the "magic mineral" known in ancient times in Europe and Asia became in the late nineteenth century an important industrial resource of particular interest to the navies of the world; and how its malign effects gradually became apparent during the present century. The media have made asbestos a notorious villain, but it still has properties and applications useful to society if they are properly controlled in the sam...

  1. Correlation of severity of hyperandrogenism with ovarian stroma to area ratio and stromal echogenicity in polycystic ovary syndrome patients

    OpenAIRE

    Pooja Gupta; Harsha Gaikwad

    2016-01-01

    Background: Polycystic ovary syndrome is one of the most common endocrine disorders of reproductive age group. Rotterdam consensus although includes ovarian volume in diagnosis of PCOS but its ovarian stroma area that corresponds histological and thus its clinical features. Methods: A prospective study conducted on 55 PCOS cases and 55 age and weight matched healthy volunteers. Detailed medical, menstrual history and examination for clinical hyperandrogenism and anthropometry was done. Fas...

  2. Estrogen receptor beta rs1271572 polymorphism and invasive ovarian carcinoma risk: pooled analysis within the Ovarian Cancer Association Consortium.

    Directory of Open Access Journals (Sweden)

    Galina Lurie

    Full Text Available The association of ovarian carcinoma risk with the polymorphism rs1271572 in the estrogen receptor beta (ESR2 gene was examined in 4946 women with primary invasive ovarian carcinoma and 6582 controls in a pooled analysis of ten case-control studies within the Ovarian Cancer Association Consortium (OCAC. All participants were non-Hispanic white women. Odds ratios (ORs and 95% confidence intervals (CIs were estimated using unconditional logistic regression adjusted for site and age. Women with the TT genotype were at increased risk of ovarian carcinoma compared to carriers of the G allele (OR = 1.10; 95%; CI: 1.01-1.21; p = 0.04; the OR was 1.09 (CI: 0.99-1.20; p = 0.07 after excluding data from the center (Hawaii that nominated this SNP for OCAC genotyping A stronger association of rs1271572 TT versus GT/GG with risk was observed among women aged ≤50 years versus older women (OR = 1.35; CI: 1.12-1.62; p = 0.002; p for interaction = 0.02 that remained statistically significant after excluding Hawaii data (OR = 1.34; CI: 1.11-1.61; p = 0.009. No heterogeneity of the association was observed by study, menopausal status, gravidity, parity, use of contraceptive or menopausal hormones, tumor histological type, or stage at diagnosis. This pooled analysis suggests that rs1271572 might influence the risk of ovarian cancer, in particular among younger women.

  3. Bone age in cerebral palsy

    OpenAIRE

    Miranda, Eduardo Régis de Alencar Bona; Palmieri, Maurício D'arc; de Assumpção, Rodrigo Montezuma César; Yamada, Helder Henzo; Rancan, Daniela Regina; Fucs, Patrícia Maria de Moraes Barros

    2013-01-01

    Objective To compare the chronological age and bone age among cerebral palsy patients in the outpatient clinic and its correlation with the type of neurological involvement, gender and functional status. Methods 401 patients with spastic cerebral palsy, and ages ranging from three months to 20 years old, submitted to radiological examination for bone age and analyzed by two independent observers according Greulich & Pyle. Results In the topographic distribution, there was a significant delay (p

  4. The chronology of the India-Asia collision

    Science.gov (United States)

    Garzanti, Eduardo; Hu, Xiumian

    2016-04-01

    Markedly diverging interpretations and incompatible scenarios have been proposed for the early stages of the Himalayan Orogeny. One view is that the northern Indian passive margin may have been involved in ophiolite obduction, arc-continent, or continent-continent collision as early as the Late Cretaceous. A different view is that India may have not come into contact with Asia until as late as the Oligo-Miocene. Ages assigned to the India-Asia collision have thus ranged rather freely from as old as 70 Ma to as young as 25-20 Ma, allowing researchers to select in remarkable liberty the age that fitted best with their lines of reasoning. In recent years, however, a growing body of stratigraphic evidence has constrained the chronology of collision with increasing accuracy and precision. Provenance analysis has ruled out early collision or ophiolite-obduction hypotheses, indicating that renewed terrigenous supply in the Maastrichtian to Danian (72-62 Ma) was derived from India in the south - rejuvenated by magmatic upwelling during the Deccan event - rather than from Asia or from an obducting ophiolite in the north (Garzanti and Hu, 2015). Integrated biostratigraphy and detrital-zircon chronostratigraphy has demonstrated that the first continent-continent contact and consequent disappearance of Neotethyan oceanic lithosphere at one point in south Tibet took place in the Selandian (59 ± 1 Ma; DeCelles et al., 2014; Wu et al., 2014; Hu et al., 2015). A major disconformity documenting tectonic uplift of carbonate platforms all along the Tethys Himalaya from the Gamba and Tingri areas of south Tibet to the Zanskar Range of the NW Himalaya, allowed dating the arrival of the orogenic wave in the inner part of the northern Indian passive margin around the Paleocene/Eocene boundary (ca. 56 Ma; Garzanti et al., 1987; Li et al., 2015). Shallow-marine seaways linked with Neotethys persisted in the Himalaya until the mid-Ypresian (ca. 50 Ma), when they were finally filled by

  5. Stem cell-like gene expression in ovarian cancer predicts type II subtype and prognosis.

    Directory of Open Access Journals (Sweden)

    Matthew Schwede

    Full Text Available Although ovarian cancer is often initially chemotherapy-sensitive, the vast majority of tumors eventually relapse and patients die of increasingly aggressive disease. Cancer stem cells are believed to have properties that allow them to survive therapy and may drive recurrent tumor growth. Cancer stem cells or cancer-initiating cells are a rare cell population and difficult to isolate experimentally. Genes that are expressed by stem cells may characterize a subset of less differentiated tumors and aid in prognostic classification of ovarian cancer. The purpose of this study was the genomic identification and characterization of a subtype of ovarian cancer that has stem cell-like gene expression. Using human and mouse gene signatures of embryonic, adult, or cancer stem cells, we performed an unsupervised bipartition class discovery on expression profiles from 145 serous ovarian tumors to identify a stem-like and more differentiated subgroup. Subtypes were reproducible and were further characterized in four independent, heterogeneous ovarian cancer datasets. We identified a stem-like subtype characterized by a 51-gene signature, which is significantly enriched in tumors with properties of Type II ovarian cancer; high grade, serous tumors, and poor survival. Conversely, the differentiated tumors share properties with Type I, including lower grade and mixed histological subtypes. The stem cell-like signature was prognostic within high-stage serous ovarian cancer, classifying a small subset of high-stage tumors with better prognosis, in the differentiated subtype. In multivariate models that adjusted for common clinical factors (including grade, stage, age, the subtype classification was still a significant predictor of relapse. The prognostic stem-like gene signature yields new insights into prognostic differences in ovarian cancer, provides a genomic context for defining Type I/II subtypes, and potential gene targets which following further

  6. Ovarian function after bone marrow transplantation performed before menarche

    OpenAIRE

    Matsumoto, M.; Shinohara, O; Ishiguro, H; Shimizu, T; Hattori, K.; Ichikawa, M; Yabe, H.; Kubota, C.; M. Yabe; Kato, S.

    1999-01-01

    AIM—To examine the long term effect of bone marrow transplantation (BMT) on ovarian function in girls.
METHODS—Eighteen girls who underwent BMT before menarche, had been disease free for more than six years, and were over 14 years of age at the time of study were investigated. The preparative regimen consisted of irradiation and chemotherapy. The occurrence of menarche and changes in basal serum follicle stimulating hormone (FSH) concentrations were studied.
RESULTS—Twelv...

  7. Ovarian Cancer Pathogenesis: A Model in Evolution

    Directory of Open Access Journals (Sweden)

    Alison M. Karst

    2010-01-01

    Full Text Available Ovarian cancer is a deadly disease for which there is no effective means of early detection. Ovarian carcinomas comprise a diverse group of neoplasms, exhibiting a wide range of morphological characteristics, clinical manifestations, genetic alterations, and tumor behaviors. This high degree of heterogeneity presents a major clinical challenge in both diagnosing and treating ovarian cancer. Furthermore, the early events leading to ovarian carcinoma development are poorly understood, thus complicating efforts to develop screening modalities for this disease. Here, we provide an overview of the current models of ovarian cancer pathogenesis, highlighting recent findings implicating the fallopian tube fimbria as a possible site of origin of ovarian carcinomas. The ovarian cancer model will continue to evolve as we learn more about the genetics and etiology of this disease.

  8. Perceived age as clinically useful biomarker of ageing: cohort study

    DEFF Research Database (Denmark)

    Christensen, Kaare; Thinggaard, Mikael; McGue, Matt;

    2009-01-01

    young men, and 11 older women (assessors); 1826 twins aged >or=70. MAIN OUTCOME MEASURES: Assessors: perceived age of twins from photographs. Twins: physical and cognitive tests and molecular biomarker of ageing (leucocyte telomere length). RESULTS: For all three groups of assessors, perceived age...... age, controlled for chronological age and sex, also correlated significantly with physical and cognitive functioning as well as with leucocyte telomere length. CONCLUSION: Perceived age-which is widely used by clinicians as a general indication of a patient's health-is a robust biomarker of ageing...

  9. Palliative Care in Improving Quality of Life and Symptoms in Patients With Stage III-IV Pancreatic or Ovarian Cancer

    Science.gov (United States)

    2014-12-18

    Recurrent Ovarian Epithelial Cancer; Recurrent Ovarian Germ Cell Tumor; Recurrent Pancreatic Cancer; Stage III Pancreatic Cancer; Stage IIIA Ovarian Epithelial Cancer; Stage IIIA Ovarian Germ Cell Tumor; Stage IIIB Ovarian Epithelial Cancer; Stage IIIB Ovarian Germ Cell Tumor; Stage IIIC Ovarian Epithelial Cancer; Stage IIIC Ovarian Germ Cell Tumor; Stage IV Ovarian Epithelial Cancer; Stage IV Ovarian Germ Cell Tumor; Stage IV Pancreatic Cancer

  10. Poly Cystic Ovarian Syndrome: an updated overview

    Directory of Open Access Journals (Sweden)

    Samer eEl Hayek

    2016-04-01

    Full Text Available 1.AbstractPoly Cystic Ovarian Syndrome (PCOS is one of the most common metabolic and reproductive disorders among women of reproductive age. Women suffering from PCOS present with a constellation of symptoms associated with menstrual dysfunction and androgen excess, which significantly impacts their quality of life. They may be at increased risk of multiple morbidities, including obesity, insulin resistance, type II diabetes mellitus, cardiovascular disease, infertility, cancer, and psychological disorders. This review summarizes what the literature has so far provided from guidelines to diagnosis of PCOS. It will also present a general overview about the morbidities associated with this disease, specifically with its more severe classic form. Finally, the review will stress on the various aspects of treatment and screening recommendations currently used in the management of this condition.

  11. Poly Cystic Ovarian Syndrome: An Updated Overview.

    Science.gov (United States)

    El Hayek, Samer; Bitar, Lynn; Hamdar, Layal H; Mirza, Fadi G; Daoud, Georges

    2016-01-01

    Poly Cystic Ovarian Syndrome (PCOS) is one of the most common metabolic and reproductive disorders among women of reproductive age. Women suffering from PCOS present with a constellation of symptoms associated with menstrual dysfunction and androgen excess, which significantly impacts their quality of life. They may be at increased risk of multiple morbidities, including obesity, insulin resistance, type II diabetes mellitus, cardiovascular disease (CVD), infertility, cancer, and psychological disorders. This review summarizes what the literature has so far provided from guidelines to diagnosis of PCOS. It will also present a general overview about the morbidities associated with this disease, specifically with its more severe classic form. Finally, the review will stress on the various aspects of treatment and screening recommendations currently used in the management of this condition. PMID:27092084

  12. Breast and ovarian cancers: a survey and possible roles for the cell surface heparan sulfate proteoglycans

    DEFF Research Database (Denmark)

    Yoneda, Atsuko; Lendorf, Maria E; Couchman, John R;

    2012-01-01

    . Occurrence of breast and ovarian cancer is high in older women. Common known risk factors of developing these cancers in addition to age are not having children or having children at a later age, the use of hormone replacement therapy, and mutations in certain genes. In addition, women with a history of...

  13. The predictive value of ovarian reserve tests for miscarriage in a population of subfertile ovulatory women

    NARCIS (Netherlands)

    M.L. Haadsma; H. Groen; V. Fidler; L.H.M. Seinen; F.J.M. Broekmans; M.J. Heineman; A. Hoek

    2009-01-01

    BACKGROUND: The increase in miscarriage rate with female age is attributed to a decline in oocyte quality. This age-related decrease of oocyte quality is accompanied by a decrease in oocyte quantity. Assessment of the number of oocytes by ovarian reserve tests (ORTs) may therefore also represent the

  14. PATTERN OF OVARIAN NEOPLASM IN RURAL POPULATION: A FIVE YEAR STUDY FROM TERTIARY CARE HOSPITAL

    Directory of Open Access Journals (Sweden)

    Umesh

    2014-02-01

    Full Text Available OBJECTIVE : The aim of the study was to know the morphological pattern of benign and malignant ovarian neoplasms and their distribution in different age groups in rural population of India. MATERIAL AND METHODS : A retrospective study of all cases of ovarian neoplasms diagnosed at department of pathology, Maharaja Medical College, Agroha during period of five year (Aug, 07 — Oct.12 was done. The tumors were classified according to WHO classification after thorough examination of slides and their distribution in different age groups was also noted. RESULTS : There were total fifty three cases of ovarian tumors noted during this period. Benign tumors comprised 81.13% and malignant tumors were 18.86%. Surface epithelial tumor emerged as the commonest variety accounting for 60.37%, followed by germ cell tumor (32.07% and sex cord stromal tumors were least common comprising 7.54 % of all ovarian neoplasm. No metastatic tumor or tumors with borderline malignancy were seen. Serous cystadenoma was the commonest tumor (43.39% followed by mature cystic teratoma (30.23%.Among the malignant tumor, malignant germ cell tumor were the commonest type (40%, followed by 30 %of each surface epithelial tumor and sex cord stromal tumor. CONCLUSION : Benign ovarian tumors are seen more common than malignant tumor. Malignant epithelial tumors are seen after the age of 30 years and malignant germ cell tumor are seen below the age of 30 years. Bilaterality is more commonly seen in malignant o varian neoplasm

  15. Bisphenol A and ovarian steroidogenesis.

    Science.gov (United States)

    Bloom, Michael S; Mok-Lin, Evelyn; Fujimoto, Victor Y

    2016-09-15

    Bisphenol A is widely used as a component in polycarbonate plastics for food and beverage packaging, epoxy linings for canned foods, and dental sealants, among other applications. Experimental literature demonstrates BPA's affinity for estrogen receptors and downstream effects on estrogen-responsive genes. Additional data suggest that BPA reduces endogenous estrogen synthesis, likely by antagonizing ovarian enzyme activities involved in sex-steroid hormone synthesis. More specifically, evidence indicates BPA-mediated disruption of STAR, CYP450scc, and HSD-3β in theca cells and CYP450 aromatase activity in granulosa cells. Yet the results of the few human studies reported to date are equivocal. It also remains in question the extent to which BPA penetrates developing ovarian follicles. Uncertainty as to the relevance of experimental BPA doses and administration routes for common human exposure levels limits extrapolation of experimental results. To more definitively address the potential risk of BPA on human ovarian steroidogenesis, additional experimental studies using biologically active BPA doses likely to reflect those within the ovarian follicle will be necessary, as will additional prospective investigations in human populations with the use of standardized assay methodology. PMID:27543890

  16. Hereditary breast and ovarian cancer

    DEFF Research Database (Denmark)

    Nielsen, Finn Cilius; van Overeem Hansen, Thomas; Sørensen, Claus Storgaard

    2016-01-01

    Genetic abnormalities in the DNA repair genes BRCA1 and BRCA2 predispose to hereditary breast and ovarian cancer (HBOC). However, only approximately 25% of cases of HBOC can be ascribed to BRCA1 and BRCA2 mutations. Recently, exome sequencing has uncovered substantial locus heterogeneity among...

  17. Genomic profile of ovarian carcinomas

    OpenAIRE

    Micci, Francesca; Haugom, Lisbeth; Vera M. Abeler; Davidson, Ben; Tropé, Claes G; Heim, Sverre

    2014-01-01

    Background It is known that all tumors studied in sufficient number to draw conclusions show characteristic/specific chromosomal rearrangements, and the identification of these chromosomes and the genes rearranged behind the aberrations may ultimately lead to a tailor-made therapy for each cancer patient. Knowledge about the acquired genomic aberrations of ovarian carcinomas is still unsatisfactory. Methods ...

  18. Ovarian Cancer Risk Prediction Models

    Science.gov (United States)

    Developing statistical models that estimate the probability of developing ovarian cancer over a defined period of time will help clinicians identify individuals at higher risk of specific cancers, allowing for earlier or more frequent screening and counseling of behavioral changes to decrease risk.

  19. Ovarian cancer and body size

    DEFF Research Database (Denmark)

    Mosgaard, Berit Jul

    2012-01-01

    Only about half the studies that have collected information on the relevance of women's height and body mass index to their risk of developing ovarian cancer have published their results, and findings are inconsistent. Here, we bring together the worldwide evidence, published and unpublished, and...

  20. Ovarian stimulation and embryo quality

    NARCIS (Netherlands)

    Baart, Esther; Macklon, Nick S.; Fauser, Bart J. C. M.

    2009-01-01

    To Study the effects of different ovarian stimulation approaches on oocyte and embryo quality, it is imperative to assess embryo quality with a reliable and objective method. Embryos rated as high quality by standardized morphological assessment are associated with higher implantation and pregnancy

  1. Ultrasound in evaluating ovarian reserve

    Directory of Open Access Journals (Sweden)

    Eman Ahmaed Shawky Sabek

    2015-12-01

    Full Text Available The objective of this study was to compare the diagnostic accuracy of transvaginal ultrasound (TVS, as a less invasive technique instead of hormonal assay to evaluate the ovarian reserve. This study included fifty-five females with breast cancer and we compared the ovarian reserve for these patients by hormonal assay through measuring the serum AntiMullerian Hormone (AMH level and follicular stimulating hormone (FSH level before and after chemotherapy, and by transvaginal ultrasound through the ovarian volume (OV calculation and counting the Antral follicles (AFC before and after chemotherapy treatment. There was decline in the AntiMullerian Hormone level after chemotherapy by 27 ± 11.19% and decrease in the Antral follicle counts by 21 ± 13.43%. In conclusion there was strong relation between AMH level and AFC which makes the use of transvaginal ultrasound is a reliable alternative method to the hormonal assay to detect the ovarian reserve.

  2. Early Detection of Ovarian Cancer

    Directory of Open Access Journals (Sweden)

    Donna Badgwell

    2007-01-01

    Full Text Available Despite advances in therapy, ovarian cancer remains the most deadly of the gynecological cancers. Less than 30% of women with advanced stage disease survive long-term. When diagnosed in stage I, up to 90% of patients can be cured with conventional surgery and chemotherapy. At present, only 25% of ovarian cancers are detected in stage I due, in part, to the absence of specific symptoms and to lack of an effective screening strategy. Early detection of ovarian cancer might significantly improve the overall survival rate of women with ovarian cancer if 1 most cancers are clonal and unifocal, arising in the ovary rather than in the peritoneum, 2 metastatic disease results from progression of clinically detectable stage I lesions, and 3 cancers remain localized for a sufficient interval to permit cost-effective screening. Given the prevalence of ovarian cancer, strategies for early detection must have high sensitivity for early stage disease (> 75%, but must have extremely high specificity (99.6% to attain a positive predictive value of at least 10%. Transvaginal sonography (TVS, serum markers and a combination of the two modalities have been evaluated for early detection of ovarian cancer. Among the serum markers, CA125 has received the most attention, but lacks the sensitivity or specificity to function alone as a screening test. Greater specificity can be achieved by combining CA125 and TVS and/or by monitoring CA125 over time. Two stage screening strategies promise to be cost effective, where abnormal serum assays prompt TVS to detect lesions that require laparotomy. Accrual has been completed for a 200,000 woman trial in the United Kingdom that will test the ability of a rising CA125 to trigger TVS and subsequent exploratory surgery. Given the heterogeneity of ovarian cancer, it is unlikely that any single marker will be sufficiently sensitive to provide an effective initial screen. Sensitivity of serum assays might be enhanced by utilizing a

  3. Ovarian response markers lead to appropriate and effective use of corifollitropin alpha in assisted reproduction.

    Science.gov (United States)

    La Marca, Antonio; D'Ippolito, Giovanni

    2014-02-01

    Corifollitropin alpha is a highly effective gonadotrophin, which maintains multifollicular growth for a week. The advantages of its administration include ease of use of the drug, making the treatment more patient friendly, resulting in a lower level of distress for the patient. At the same time, the pregnancy rate resulting from its use in IVF/intracytoplasmic sperm injection cycles is similar to that found when daily recombinant FSH is administered. The ovarian response to corifollitropin alpha is dependent on clinically established predictors such as baseline FSH, antral follicle count (AFC) and age. There is a general trend towards a higher ovarian response with an increasing AFC and the number of oocytes per attempt decreased with increasing baseline FSH and age. Even if the risk of ovarian hyperstimulation syndrome following corifollitropin alpha is very similar to the rate reported in literature for young women undergoing IVF, the risk of overstimulation may be reduced by avoiding maximal ovarian stimulation in women anticipated to be hyperresponders. High basal anti-Müllerian hormone and/or AFC can identify women with enhanced functional ovarian reserve at risk of overstimulation, and the risk is even higher if maximally stimulated with corifollitropin alpha or high dose of daily recombinant FSH. Corifollitropin alpha is a highly effective gonadotrophin which maintains multifollicular growth for a week. The ovarian response to corifollitropin was demonstrated to be dependent on clinically established predictors such as baseline FSH, antral follicle count (AFC) and age. There was a general trend toward a higher ovarian response with an increasing AFC and the mean number of oocytes per attempt decreased with increasing baseline FSH and age. Even if the risk of ovarian hyperstimulation syndrome (OHSS) following corifollitropin alpha is very similar to the rate of OHSS reported in literature for young women undergoing IVF, the risk of overstimulation may be

  4. Ovarian cancer in BRCA1/2 mutation carriers : The impact of mutation position and family history on the cancer risk

    NARCIS (Netherlands)

    Teixeira, Natalja; Mourits, Marian J. E.; Vos, Janet R.; van der Kolk, Donna M.; Jansen, Liesbeth; Oosterwijk, Jan; de Bock, Geertruida H.

    2015-01-01

    Objectives: Assessing the combined impact of mutation position, regarding the ovarian cancer cluster region (OCCR), and type of cancer family history (FH) on age-related penetrance of ovarian cancer (OC) in women from BRCA/2 families from the northern Netherlands. Study design: A consecutive series

  5. Diabetes prevalence is associated with serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in US middle-aged Caucasian men and women: a cross-sectional analysis within the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial.

    Science.gov (United States)

    Brock, Kaye E; Huang, Wen-Yi; Fraser, David R; Ke, Liang; Tseng, Marilyn; Mason, Rebecca S; Stolzenberg-Solomon, Rachael Z; Freedman, D Michal; Ahn, Jiyoung; Peters, Ulrike; McCarty, Catherine; Hollis, Bruce W; Ziegler, Regina G; Purdue, Mark P; Graubard, Barry I

    2011-08-01

    Hypovitaminosis D may be associated with diabetes, hypertension and CHD. However, because studies examining the associations of all three chronic conditions with circulating 25-hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D (1,25(OH)(2)D) are limited, we examined these associations in the US Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial (n 2465). Caucasian PLCO participants selected as controls in previous nested case-control studies of 25(OH)D and 1,25(OH)(2)D were included in this analysis. Diabetes, CHD and hypertension prevalence, risk factors for these conditions and intake of vitamin D and Ca were collected from a baseline questionnaire. Results indicated that serum levels of 25(OH)D were low (smoking history, BMI, physical activity, total dietary energy and vitamin D and Ca intake, only diabetes was significantly associated with lower 25(OH)D and 1,25(OH)(2)D levels. Caucasians who had 25(OH)D ≥ 80 nmol/l were half as likely to have diabetes (OR 0·5 (95 % CI 0·3, 0·9)) compared with those who had 25(OH)D studies. PMID:21736838

  6. Ovarian cysts on prenatal MRI

    International Nuclear Information System (INIS)

    Objective: Ovarian cysts are the most frequently encountered intra-abdominal masses in females in utero. They may, at times, require perinatal intervention. Using magnetic resonance imaging (MRI) as an adjunct to ultrasonography (US) in prenatal diagnosis, we sought to demonstrate the ability to visualize ovarian cysts on prenatal MRI. Materials and methods: This retrospective study included 17 fetal MRI scans from 16 female fetuses (23–37 gestational weeks) with an MRI diagnosis of ovarian cysts after suspicious US findings. A multiplanar MRI protocol was applied to image and to characterize the cysts. The US and MRI findings were compared, and the prenatal findings were compared with postnatal imaging findings or histopathology. Results: Simple ovarian cysts were found in 10/16 cases and complex cysts in 7/16 cases, including one case with both. In 11/16 (69%) cases, US and MRI diagnoses were in agreement, and, in 5/16 (31%) cases, MRI specified or expanded the US diagnosis. In 6/16 cases, postnatal US showed that the cysts spontaneously resolved or decreased in size, and in 1/16 cases, postnatal imaging confirmed a hemorrhagic cyst. In 4/16 cases, the prenatal diagnoses were confirmed by surgery/histopathology, and for the rest, postnatal correlation was not available. Conclusion: Our results illustrate the MRI visualization of ovarian cysts in utero. In most cases, MRI will confirm the US diagnosis. In certain cases, MRI may provide further diagnostic information, additional to US, which is the standard technique for diagnosis, monitoring, and treatment planning.

  7. Ovarian cysts on prenatal MRI

    Energy Technology Data Exchange (ETDEWEB)

    Nemec, Ursula [Department of Radiology, Division of Neuroradiology and Musculoskeletal Radiology, Medical University Vienna, Waehringer Guertel 18-20, A-1090 Vienna (Austria); Nemec, Stefan F., E-mail: stefan.nemec@meduniwien.ac.at [Department of Radiology, Division of Neuroradiology and Musculoskeletal Radiology, Medical University Vienna, Waehringer Guertel 18-20, A-1090 Vienna (Austria); Medical Genetics Institute, Cedars Sinai Medical Center, 8700 Beverly Boulevard, PACT Suite 400, Los Angeles, CA 90048 (United States); Bettelheim, Dieter [Department of Obstetrics and Gynaecology, Division of Prenatal Diagnosis and Therapy, Medical University Vienna, Waehringer Guertel 18-20, A-1090 Vienna (Austria); Brugger, Peter C. [Center of Anatomy and Cell Biology, Integrative Morphology Group, Medical University Vienna, Waehringerstrasse 13, A-1090 Vienna (Austria); Horcher, Ernst [Department of Pediatric Surgery, Medical University Vienna, Waehringer Guertel 18-20, A-1090 Vienna (Austria); Schoepf, Veronika [Department of Radiology, Division of Neuroradiology and Musculoskeletal Radiology, Medical University Vienna, Waehringer Guertel 18-20, A-1090 Vienna (Austria); Graham, John M.; Rimoin, David L. [Medical Genetics Institute, Cedars Sinai Medical Center, 8700 Beverly Boulevard, PACT Suite 400, Los Angeles, CA 90048 (United States); Weber, Michael; Prayer, Daniela [Department of Radiology, Division of Neuroradiology and Musculoskeletal Radiology, Medical University Vienna, Waehringer Guertel 18-20, A-1090 Vienna (Austria)

    2012-08-15

    Objective: Ovarian cysts are the most frequently encountered intra-abdominal masses in females in utero. They may, at times, require perinatal intervention. Using magnetic resonance imaging (MRI) as an adjunct to ultrasonography (US) in prenatal diagnosis, we sought to demonstrate the ability to visualize ovarian cysts on prenatal MRI. Materials and methods: This retrospective study included 17 fetal MRI scans from 16 female fetuses (23-37 gestational weeks) with an MRI diagnosis of ovarian cysts after suspicious US findings. A multiplanar MRI protocol was applied to image and to characterize the cysts. The US and MRI findings were compared, and the prenatal findings were compared with postnatal imaging findings or histopathology. Results: Simple ovarian cysts were found in 10/16 cases and complex cysts in 7/16 cases, including one case with both. In 11/16 (69%) cases, US and MRI diagnoses were in agreement, and, in 5/16 (31%) cases, MRI specified or expanded the US diagnosis. In 6/16 cases, postnatal US showed that the cysts spontaneously resolved or decreased in size, and in 1/16 cases, postnatal imaging confirmed a hemorrhagic cyst. In 4/16 cases, the prenatal diagnoses were confirmed by surgery/histopathology, and for the rest, postnatal correlation was not available. Conclusion: Our results illustrate the MRI visualization of ovarian cysts in utero. In most cases, MRI will confirm the US diagnosis. In certain cases, MRI may provide further diagnostic information, additional to US, which is the standard technique for diagnosis, monitoring, and treatment planning.

  8. Perceived age is associated with bone status in women aged 25-93 years

    DEFF Research Database (Denmark)

    Nielsen, Barbara Rubek; Linneberg, Allan; Christensen, Kaare;

    2015-01-01

    with the hypothesis (e.g., β -0.29 %; 95 % confidence interval (CI) 0.55, 0.03). Statistical significance of the association of age-adjusted facial RPACA with BMD was found. Adjusted for body mass index (BMI), menopause, and hormone replacement therapy, higher RPACA from all photographic presentations were...... for chronological age. This is a cross-sectional study of 460 women aged 25-93 years. BMD/TBS was measured. Twenty physicians assessed age from facial and whole-body photographs. Residual PA (RPACA) was calculated from the regression of PA on chronological age. Participants were divided into "looking old" (LO...

  9. Critical review of a new volcanic eruption chronology

    Science.gov (United States)

    Neuhäuser, Dagmar L.; Neuhäuser, Ralph

    2016-04-01

    Sigl. et al. (2015, Nature) present historical evidence for 32 volcanic eruptions to evaluate their new polar ice core 10-Be chronology - 24 are dated within three years of sulfur layers in polar ice. Most of them can be interpreted as weather phenomena (Babylonia: disk of sun like moon, reported for only one day, e.g. extinction due to clouds), Chinese sunspot reports (pellet, black vapor, etc.), solar eclipses, normal ice-halos and coronae (ring, bow, etc.), one aurora (redness), red suns due to mist drops in wet fog or fire-smoke, etc. Volcanic dust may facilitate detections of sunspots and formation of Bishop's ring, but tend to inhibit ice-halos, which are otherwise often reported in chronicles. We are left with three reports possibly indicating volcanic eruptions, namely fulfilling genuine criteria for atmospheric disturbances due to volcanic dust, e.g. bluish or faint sun, orange sky, or fainting of stars for months (BCE 208, 44-42, and 32). Among the volcanic eruptions used to fix the chronology (CE 536, 626, 939, 1257), the reports cited for the 930s deal only with 1-2 days, at least one reports an eclipse. In the new chronology, there is a sulfur detection eight years after the Vesuvius eruption, but none in CE 79. It may appear surprising that, from BCE 500 to 1, all five northern sulfur peaks labeled in figure 2 in Sigl et al. are systematically later by 2-4 years than the (corresponding?) southern peaks, while all five southern peaks from CE 100 to 600 labeled in figure 2 are systematically later by 1-4 years than the (corresponding?) northern peaks. Furthermore, in most of their six strongest volcanic eruptions, temperatures decreased years before their sulfur dating - correlated with weak solar activity as seen in radiocarbon, so that volcanic climate forcing appears dubious here. Also, their 10-Be peaks at CE 775 and 994 are neither significant nor certain in dating.

  10. Chronology of Mercury's geological and geophysical evolution - the Vulcanoid hypothesis

    International Nuclear Information System (INIS)

    The possibility that constraints on Mercury's chronology can be relaxed through reference to a Mercury-specific bombarding population of planetesimals interior to its orbit, and therefore only occasionally encountering the planet at times of secular perturbations, is investigated. While such vulcanoids may have been a significant source of early cratering, those in the pertinent orbits are depleted by mutual collisions and can therefore only furnish a modest extension of the heavy bombardment period. A search is conducted for vulcanoids further within Mercury's orbit; evidence that Mercury's intercrater plains are of volcanic origin is discussed. 99 references

  11. A new chronology for the Moon and Mercury

    CERN Document Server

    Marchi, S; Cremonese, G; Massironi, M; Martellato, E

    2009-01-01

    In this paper we present a new method for dating the surface of the Moon, obtained by modeling the incoming flux of impactors and converting it into a size distribution of resulting craters. We compare the results from this model with the standard chronology for the Moon showing their similarities and discrepancies. In particular, we find indications of a non-constant impactor flux in the last 500 Myr and also discuss the implications of our findings for the Late Heavy Bombardment hypothesis. We also show the potential of our model for accurate dating of other inner Solar System bodies, by applying it to Mercury.

  12. Extension of Chronological Calculus for Dynamical Systems on Manifolds

    OpenAIRE

    Kipka, Robert J.; Ledyaev, Yuri S.

    2014-01-01

    We propose an extension of the Chronological Calculus, developed by Agrachev and Gamkrelidze for the case of $C^\\infty$-smooth dynamical systems on finite-dimensional $C^\\infty$-smooth manifolds, to the case of $C^m$-smooth dynamical systems and infinite-dimensional $C^m$-manifolds. Due to a relaxation in the underlying structure of the calculus, this extension provides a powerful computational tool without recourse to the theory of calculus in Fr\\'echet spaces required by the classical Chron...

  13. The problem of the neolithisation process chronology in Povolzhye

    Directory of Open Access Journals (Sweden)

    Aleksandr Vybornov

    2013-12-01

    Full Text Available The Lower and Middle Volga basin regions border the Caucasus and Central Asia in the South. These regions are important in the study of the neolithisation process in Europe and the chronology of Neolithic cultures is of great significance in this respect. New 14C dates of different organic materials from archaeological sites in these regions have been obtained in the last five years. According to these data, the beginning of neolithisation in North Caspian region can be dated to the beginning of the 5th millennium BC; but in the Povolzhye it happened at least a millennium earlier.

  14. Clinicopathologic features of ovarian neoplasms with emphasis on borderline ovarian tumors: an institutional perspective

    OpenAIRE

    Hashmi, Atif Ali; Hussain, Zubaida Fida; Bhagwani, Aneel Roy; Edhi, Muhammad Muzzammil; Faridi, Naveen; Hussain, Syed Danish; Khan, Mehmood

    2016-01-01

    Background Ovarian cancer is the most lethal gynecologic malignancy and it represents third most common malignancy in Karachi (after breast and oral cancer). Due to lack of well established cancer registry in our country, changing trends of ovarian tumors has not been determined. Therefore we aimed to establish the current trends and classification of ovarian tumors in our setup according to latest WHO guidelines. Methods We retrospectively analyzed 162 cases of ovarian tumors that underwent ...

  15. Ovarian Cancer Risk Factors in a Defined Population Using Rare Event Logistic Regression

    Directory of Open Access Journals (Sweden)

    Elham Haem

    2015-01-01

    Full Text Available Background: This study evaluated the role of family history of cancer and gynecologic factors in relation to the etiology of ovarian cancer in a low socioeconomic population in Iran. Methods: From 2007-2009 we conducted a screening program on women with insurance coverage provided by the Imam Khomeini Relief Foundation. A total of 26788 women participated in this study of whom 76 cases had ovarian cancer and 26712 were considered as controls. We used rare event logistic (ReLogit regression analysis with a prior correction method that used the Zelig package in R to obtain odds ratio estimates and confidence intervals. Results: Ovarian cancer was more frequent among postmenopausal than premenopausal (odds ratio: 2.30; confidence interval: 1.17-4.49 women. We observed increased risk for this disease in women with histories of hormone replacement therapy compared to those with no history (odds ratio: 2.36; confidence interval: 1.13-4.91. A greater increase in ovarian cancer was observed in women with family histories of breast (odds ratio: 2.88; confidence interval: 1.44-5.77, ovarian (odds ratio: 11.27; confidence interval: 5.63-22.54 and all cancer sites (odds ratio: 2.95; confidence interval: 1.71-5.08. However, the use of oral contraceptive pills was significantly associated with lower risk for ovarian cancer (odds ratio: 0.47; confidence interval: 0.28-0.79. There was no association between ovarian cancer and age, marital status, occupation, education level, age at menarche, age at first pregnancy and number of pregnancies. Conclusion: Ovarian cancer was considered a rare event. Thus we deemed it necessary to explore the associated risk factors using ReLogit with a prior correction method. The risk factors for ovarian cancer were menopause, history of hormone replacement therapy and family history of cancer of the breast, ovaries and other sites. Oral use of contraceptive pills showed a protective effect on risk for ovarian cancer.

  16. Early Detection Biomarkers for Ovarian Cancer

    Directory of Open Access Journals (Sweden)

    Sreeja Sarojini

    2012-01-01

    Full Text Available Despite the widespread use of conventional and contemporary methods to detect ovarian cancer development, ovarian cancer remains a common and commonly fatal gynecological malignancy. The identification and validation of early detection biomarkers highly specific to ovarian cancer, which would permit development of minimally invasive screening methods for detecting early onset of the disease, are urgently needed. Current practices for early detection of ovarian cancer include transvaginal ultrasonography, biomarker analysis, or a combination of both. In this paper we review recent research on novel and robust biomarkers for early detection of ovarian cancer and provide specific details on their contributions to tumorigenesis. Promising biomarkers for early detection of ovarian cancer include KLK6/7, GSTT1, PRSS8, FOLR1, ALDH1, and miRNAs.

  17. Ovarian cancer immunotherapy: opportunities, progresses and challenges

    Directory of Open Access Journals (Sweden)

    Stevens Richard

    2010-02-01

    Full Text Available Abstract Due to the low survival rates from invasive ovarian cancer, new effective treatment modalities are urgently needed. Compelling evidence indicates that the immune response against ovarian cancer may play an important role in controlling this disease. We herein summarize multiple immune-based strategies that have been proposed and tested for potential therapeutic benefit against advanced stage ovarian cancer. We will examine the evidence for the premise that an effective therapeutic vaccine against ovarian cancer is useful not only for inducing remission of the disease but also for preventing disease relapse. We will also highlight the questions and challenges in the development of ovarian cancer vaccines, and critically discuss the limitations of some of the existing immunotherapeutic strategies. Finally, we will summarize our own experience on the use of patient-specific tumor-derived heat shock protein-peptide complex for the treatment of advanced ovarian cancer.

  18. Ovarian malignant mixed germ cell tumor with clear cell carcinoma in a postmenopausal woman

    OpenAIRE

    Yu, Xiu-Jie; Zhang, Lin; Liu, Zai-Ping; Shi, Yi-Quan; Liu, Yi-Xin

    2014-01-01

    Malignant germ cell tumors of the ovary are very rare and account for about 2-5% of all ovarian tumors of germ origin. Most patients are adolescent and young women, approximately two-thirds of them are under 20 years of age, occasionally in postmenopausal women. But clear cell carcinoma usually occurs in older patients (median age: 57-year old), and closely related with endometriosis. Here we report a case of a 55-year old woman with right ovarian mass that discovered by B ultrasonic. Her ser...

  19. RUPTURED MALIGNANT GERM CELL OVARIAN TUMOR IN A 14 YEAR OLD GIRL: A CASE REPORT

    OpenAIRE

    Sunita Sudhir; Sunita,; Vrunda; Komal

    2014-01-01

    Immature teratoma accounts for 10 – 20% of all ovarian neoplasms in women less than 20 years of age with peak incidence between 15 – 19 years and they account for 30% of deaths arising from ovarian cancer in this age group.(1) Immature teratomas are rarely found to be bilateral,(2) Immature teratomas are malignant in nature and the most common sites of dessemination are peritoneum, retroperitoneal lymph nodes, hematogenous spread to Lung liver and brain is unusual.(3) We report a case of an i...

  20. Genetically modified mouse models for premature ovarian failure (POF).

    Science.gov (United States)

    Jagarlamudi, Krishna; Reddy, Pradeep; Adhikari, Deepak; Liu, Kui

    2010-02-01

    Premature ovarian failure (POF) is a complex disorder that affects approximately 1% of women. POF is characterized by the depletion of functional ovarian follicles before the age of 40 years, and clinically, patients may present with primary amenorrhea or secondary amenorrhea. Although some genes have been hypothesized to be candidates responsible for POF, the etiology of most of the cases is idiopathic, with the underlying causes still unidentified because of the heterogeneity of the disease. In this review, we consider some mutant mouse models that exhibit phenotypes which are comparable to human POF, and we suggest that the use of these mouse models may help us to gain a better understanding of the molecular mechanisms underlying POF in humans.

  1. Spontaneous Heterotopic Pregnancy, Simultaneous Ovarian, and Intrauterine: A Case Report

    Directory of Open Access Journals (Sweden)

    Francesca Basile

    2012-01-01

    Full Text Available Spontaneous heterotopic pregnancy is a rare clinical condition in which intrauterine and extrauterine pregnancies occur at the same time. The occurrence of an ovarian heterotopic pregnancy is a singular event as it comprises only 2.3% of all heterotopic pregnancies, extremely rare among women who conceive naturally. A case of a 28-year old patient was treated for spontaneously conceived heterotopic pregnancy. The patient was admitted to our center with lower abdominal pain and amenorrhoea. A transvaginal ultrasound scan showed an ovarian and an intrauterine heterotopic pregnancy. This was managed laparoscopically. Considering spontaneous pregnancies, every physician treating women of reproductive age should be aware of the possibility of heterotopic pregnancy. It can occur in the absence of any predisposing risk factors; only with an early diagnosis and treatment the intrauterine pregnancies will reach viability with a great chance of a favorable obstetric outcome.

  2. Neonatal overfeeding induces early decline of the ovarian reserve: Implications for the role of leptin.

    Science.gov (United States)

    Sominsky, Luba; Ziko, Ilvana; Soch, Alita; Smith, Jeremy T; Spencer, Sarah J

    2016-08-15

    Early life nutrition is crucial for reproduction. Overweight and obese girls are more likely to experience early menarche, increasing the risk of adult disease. We have previously demonstrated neonatal overfeeding in the rat leads to accelerated growth, early puberty and increased circulating levels of leptin, an adipocyte-derived hormone that regulates puberty. However, the long-term consequences of accelerated puberty and metabolic dysfunction on ovarian reserve are unknown. Here we show that neonatal overfeeding reduced the number of ovarian follicles in adult rats; specifically, the primordial follicle pool was reduced compared to controls. The reduction of ovarian reserve coincided with a diminished release of pituitary gonadotropins at ovulation and altered expression of ovarian markers important for follicular recruitment and survival. These changes were associated with increased levels of ovarian leptin and its receptor. Postnatal administration of leptin antagonist did not reverse the weight gain induced by early life overfeeding, but rescued the decline in the primordial follicle pool and abolished the differences in circulating leptin and gonadotropins. Our findings suggest that the acute effects of elevated circulating leptin may be responsible for the long-term reproductive outcomes after neonatal overfeeding, leading to premature ovarian ageing and changes in reproductive efficiency. PMID:27154163

  3. Decidualized Ovarian Endometrioma in a Pregnant Woman Mimicking Ovarian Malignancy: Magnetic Resonance Imaging and Ultrasonographic Findings

    Directory of Open Access Journals (Sweden)

    Izza Rozalli

    2015-10-01

    Full Text Available Decidualized ovarian endometrioma is a rare phenomenon in pregnancy, which can mimic ovarian malignancy in imaging and often poses a diagnostic challenge. We report a case of a large ruptured decidualized ovarian endometrioma in a 15 weeks gestation patient, and we will describe the imaging characteristics (ultrasonography and MR imaging findings and the histopathological findings (macro- and microscopically.

  4. Decidualized Ovarian Endometrioma in a Pregnant Woman Mimicking Ovarian Malignancy: Magnetic Resonance Imaging and Ultrasonographic Findings.

    Science.gov (United States)

    Izza Rozalli, Faizatul; Rahmat, Kartini; Fadzli, Farhana; Boylan, Colm; Deb, Pratima

    2015-10-01

    Decidualized ovarian endometrioma is a rare phenomenon in pregnancy, which can mimic ovarian malignancy in imaging and often poses a diagnostic challenge. We report a case of a large ruptured decidualized ovarian endometrioma in a 15 weeks gestation patient, and we will describe the imaging characteristics (ultrasonography and MR imaging findings) and the histopathological findings (macro- and microscopically). PMID:26715980

  5. Decidualized Ovarian Endometrioma in a Pregnant Woman Mimicking Ovarian Malignancy: Magnetic Resonance Imaging and Ultrasonographic Findings

    OpenAIRE

    Izza Rozalli; Rahmat; Fadzli; Boylan; Deb

    2015-01-01

    Decidualized ovarian endometrioma is a rare phenomenon in pregnancy, which can mimic ovarian malignancy in imaging and often poses a diagnostic challenge. We report a case of a large ruptured decidualized ovarian endometrioma in a 15 weeks gestation patient, and we will describe the imaging characteristics (ultrasonography and MR imaging findings) and the histopathological findings (macro- and microscopically).

  6. Incipient ovarian failure and premature ovarian failure show the same immunological profile

    NARCIS (Netherlands)

    van Kasteren, YM; von Blomberg, M; Hoek, A; de Koning, C; Lambalk, N; van Montfrans, J; Kuik, J

    2000-01-01

    PROBLEM: Incipient ovarian failure (IOF) is characterized by regular menstrual cycles, infertility and a raised early-follicular FSH in women under 40. IOF might be a precursor or a mitigated form of premature ovarian failure (POF). Disturbances in the immune system may play a role in ovarian failur

  7. Immature ovarian teratoma in a postmenopausal woman

    DEFF Research Database (Denmark)

    Ornvold, K; Detlefsen, G U; Horn, T;

    1987-01-01

    We report the first case of immature ovarian teratoma occurring after menopause in a 57-year-old, 3 years postmenopausal woman. Within one year after resection of the teratoma she developed peritoneal botryoid rhabdomyosarcoma, which probably originated from initially unrecognized rhabdomyoblasts...... in the teratoma. The patient died 6 months later from progressive disease after a transient adriamycin-induced tumor response. The literature on ovarian immature teratoma and ovarian rhabdomyosarcoma is briefly reviewed, and the available treatment is discussed....

  8. Aspects of the Aging Stigma.

    Science.gov (United States)

    Luken, Paul C.

    Although social gerontologists recognize the heterogeneous nature of elderly populations, they have relied on the use of aggregate data and chronological age rather than sociological variables in their research. The notion of stigma, as developed by Goffman (1963), applied to the elderly focuses on social relationships rather than individual…

  9. Irregular menses predicts ovarian cancer: Prospective evidence from the Child Health and Development Studies.

    Science.gov (United States)

    Cirillo, Piera M; Wang, Erica T; Cedars, Marcelle I; Chen, Lee-May; Cohn, Barbara A

    2016-09-01

    We tested the hypothesis that irregular menstruation predicts lower risk for ovarian cancer, possibly due to less frequent ovulation. We conducted a 50-year prospective study of 15,528 mothers in the Child Health and Development Studies cohort recruited from the Kaiser Foundation Health Plan from 1959 to 1966. Irregular menstruation was classified via medical record and self-report at age 26. We identified 116 cases and 84 deaths due to ovarian cancer through 2011 via linkage to the California Cancer Registry and Vital Statistics. Contrary to expectation, women with irregular menstrual cycles had a higher risk of ovarian cancer incidence and mortality over the 50-year follow-up. Associations increased with age (p age 70 (95% confidence interval [CI] = 1.1, 3.4) rising to a 3-fold increase by age 77 (95% CI = 1.5, 6.7 for incidence; 95% CI = 1.4, 5.9 for mortality). We also found a 3-fold higher risk of mortality for high-grade serous tumors (95% CI = 1.3, 7.6) that did not vary by age. This is the first prospective study to show an association between irregular menstruation and ovarian cancer-we unexpectedly found higher risk for women with irregular cycles. These women are easy to identify and many may have polycystic ovarian syndrome. Classifying high-risk phenotypes such as irregular menstruation creates opportunities to find novel early biomarkers, refine clinical screening protocols and potentially develop new risk reduction strategies. These efforts can lead to earlier detection and better survival for ovarian cancer. PMID:27082375

  10. A THREE YEAR RETROSPECTIVE STUDY OF OVARIAN NEOPLASMS WITH SPECIAL EMPHASIS ON SURFACE EPITHELIAL TUMOURS

    Directory of Open Access Journals (Sweden)

    Krishna Bharathi Yarlagadda

    2016-07-01

    Full Text Available BACKGROUND Ovarian tumours being second most common gynaecological cancer in India account for 30% of all cancers of female genital tract. Study conducted to determine relative frequencies of various histological types based on WHO classification and their age distribution with particular emphasis on surface epithelial tumours. This study is undertaken to find out the frequency of incidence of different histopathological subtypes with particular emphasis on surface epithelial tumours and age distribution of ovarian tumours in our institute located in coastal Andhra Pradesh. METHODS This is a retrospective study of 100 cases of ovarian neoplasms collected during a period of 3 years from June 2013 to May 2016 from the Department of Pathology, Katuri Medical College and Hospital, Chinakondrupadu, Guntur, A. P, India. The patients attending our hospital are mostly from rural areas around. Paraffin blocks of all 100 ovarian neoplasms retrieved. Complete clinical and radiological findings analysed from our records. RESULTS The tumours are grouped according to the nature of tumour whether benign or borderline or malignant according to cell of origin, histological subtyping, and age group. Surface epithelial tumours are the most common. Benign tumours outnumber the malignant tumours. Benign ovarian tumours showed a peak in 21-40 Yrs. age group and malignant in the age group of 41- 60 Yrs. Results of our study compared with other studies. CONCLUSION Because of the geographic location, poverty, and illiteracy, patients seek medical advice late. So, awareness among public by health education, passive surveillance, and community screening facility will be helpful in early detection of ovarian neoplasms.

  11. The expression of AMH protein between in different developmental stages of the adult mice follicle and in ovarian tissue of different ages%AMH蛋白在性成熟小鼠卵泡发育不同阶段及自然衰老过程卵巢组织中的表达变化

    Institute of Scientific and Technical Information of China (English)

    田勇; 赖志文; 石良艳; 杨书红; 罗爱月; 王世宣

    2012-01-01

    目的:通过检测抗苗勒氏管激素(AMH)蛋白在成年小鼠卵泡发育不同阶段和自然衰老过程卵巢中的表达变化,为卵泡的生长发育调控及卵巢衰老发生发展的机制研究奠定理论基础.方法:选用12,24,36,48周龄自然衰老C57 BL/6小鼠为模型.收集12周龄C57BL/6小鼠不同发育阶段的卵巢和24,36,48周龄自然衰老C57BL/6小鼠卵巢.采用免疫组织化学方法和蛋白印迹技术检测各组卵巢中AMH蛋白的表达.结果:免疫组织化学显示,AMH蛋白在始基卵泡、初级卵泡,次级卵泡、窦状卵泡的颗粒细胞中均有表达,但在黄体和闭锁卵泡的颗粒细胞中未见表达.始基卵泡颗粒细胞中AMH蛋白表达明显低于初级卵泡、次级卵泡和窦状卵泡(P<0.05);窦状卵泡颗粒细胞中AMH蛋白表达明显低于初级卵泡和次级卵泡(P<0.05);初级卵泡和次级卵泡的AMH蛋白表达未见明显差异(P>0.05).不同鼠龄的小鼠同级别卵泡颗粒细胞AMH的染色程度未见明显差异;但是24周龄以后间质中开始出现AMH蛋白表达,并且AMH的表达随鼠龄增加而上升;48周龄小鼠卵巢间质中AMH蛋白表达明显高于24周龄和36周龄(P<0.05);24周龄与36周龄比较差异无统计学意义(P>0.05).蛋白印迹技术结果显示,AMH蛋白在小鼠卵巢组织中的表达随鼠龄增加而降低,差异有统计学意义(P<0.05).结论:AMH蛋白主要表达于卵泡发育早期阶段的颗粒细胞,并且其在间质中随鼠龄增加表达增强,但是在整个卵巢组织中其表达量随鼠龄增加而降低.提示AMH可能在卵泡发育以及卵巢衰老中起重要的调控作用.%Objective:Detecting the protein expressions of Anti mullerian hormone ( AMH ) in different developmental stages of the adult mice follicles and ovarian tissue of differ-ent ages which to establish a theory foundation for the regulation of follicle development and the mechanism researching of the development of

  12. Chronologic changes of free fat graft in rabbit using CT

    International Nuclear Information System (INIS)

    Free fat grafts are now used for preventing osteal readhesion, filling dead space, and protecting grafted nerves and vessels. However, it is reported that grafted fat tissue is unstable resulting in high risk of cicatrization and infection. We grafted free fat to a rabbit's back and observed the chronologic change using CT. Ten adult male Japanese white rabbits (3.5 kg) were used. In five rabbits, fat tissue was obtained from the back under general anaesthesia, and transplanted into the back about 50 mm posterior from the donor site. CT was taken in the fixed scan condition five times (preoperation, immediate postoperation, postoperative 1-month, 2-month, and 3-month). In the remaining five rabbits, only CT scan was taken three times as a control. It was observed that we compared preoperative fat volume with the postoperative volume using RealINTAGE. Grafted fat tissue decreased postoperatively at 1-month and completely disappeared at 3-months. We were able to prove that CT scan is effective to observe the chronologic change of grafted fat tissue. Techniques of tissue engineering are necessary for survival of grafted fat tissue. (author)

  13. Changes in Coagulation and Fibrinolytic Indices in Women with Polycystic Ovarian Syndrome Undergoing Controlled Ovarian Hyperstimulation

    Directory of Open Access Journals (Sweden)

    Ying Huang

    2014-01-01

    Full Text Available Background. Polycystic ovarian syndrome (PCOS women undergoing in vitro fertilization and embryo transfer (IVF-ET treatment always attain a low cumulative pregnancy rate disaccording with the satisfactory number of oocytes. Objective. We aim to evaluate the status of coagulation and fibrinolytic system in PCOS patients undergoing controlled ovarian hyperstimulation (COH process. Method. Of the 97 women, 30 patients with PCOS composed the study group; 67 women of child-bearing age with normal endocrine function composed the control group. All participants underwent GnRH agonist standard long protocol, and plasma HCY, FVIII, FX, and D-dimer levels as well as hormone parameters were measured at day of full downregulation, hCG priming, and embryos transfer. Results. On day of full downregulation, FX levels were significantly higher in PCOS group (P<0.01. On hCG priming day, FX and estrogen levels in PCOS group were higher than in the control group and FVIII levels were significantly lower on day of embryos transfer whereas FX and E2 levels were significantly higher in PCOS group. Conclusion. Hypercoagulable state during peri-implantation phase would probably lead to poor microcirculation of endometrium and be one of the most important disadvantages of successful implantation and subsequent clinical pregnancy.

  14. Primary ovarian pregnancy with intrauterine contraceptive device

    Directory of Open Access Journals (Sweden)

    Sabita Saichandran

    2015-08-01

    Full Text Available Primary ovarian pregnancy is a rare variant of extra-uterine pregnancies. However the cause for primary ovarian pregnancy is still obscure. Some studies have reported a strong correlation of this condition with intrauterine contraceptive device (IUCD. The diagnosis of ovarian ectopic pregnancy is seldom made before surgery though ultrasound proves to be an invaluable tool for its diagnosis. We describe here about a case of primary ovarian pregnancy which was diagnosed only at the time of operation and was managed with wedge resection of the ovary. [Int J Reprod Contracept Obstet Gynecol 2015; 4(4.000: 1191-1193

  15. Vitrification of in vitro matured oocytes collected from surplus ovarian medulla tissue resulting from fertility preservation of ovarian cortex tissue

    DEFF Research Database (Denmark)

    Yin, Huiqun; Jiang, Hong; Kristensen, Stine Gry;

    2016-01-01

    and warming. METHODS: 36 patients aged from 8 to 41 years who had one ovary excised for fertility preservation were included. Oocytes were collected from the medulla tissue and matured in vitro 44-48 h followed by vitrification. Number of oocytes collected, the rates of maturation and post-warming survival...... following in vitro maturation (IVM) of immature oocytes collected from medulla tissue, of which two survived vitrification and warming. This approach represents an add-on method to potentially augment the fertility opportunity for cancer patients, especially in young women with cancer where transplantation......PURPOSE: The aim of the study was to investigate the maturation rate of immature oocytes collected from ovarian medulla tissue normally discarded during preparation of ovarian cortical tissue for fertility preservation. Further we evaluated survival of derived MII oocytes following vitrification...

  16. [Cytostatic treatment of ovarian carcinoma].

    Science.gov (United States)

    Neijt, J P

    1999-10-30

    Shortly after treatment with the cytostatic combination of cisplatin and paclitaxel was generally accepted as the standard therapy for patients with epithelial ovarian carcinoma, many have come to regard the combination of carboplatin and paclitaxel as a better choice. The latter combination causes fewer side effects and may be used in the outpatient clinic. Conceivably, the carboplatin-paclitaxel scheme will shortly have to be adjusted again owing to results of current research. The intensive basic research of recent years, namely, is beginning to yield benefits for the therapeutic arsenal against ovarian carcinoma. Possibilities are inhibitors of the breakdown of extracellular matrix (such as marimastat) and inhibitors of signal transduction (such as trastuzumab). PMID:10578409

  17. Extracellular matrix in ovarian follicles.

    Science.gov (United States)

    Rodgers, R J; Irving-Rodgers, H F; van Wezel, I L

    2000-05-25

    A lot is known about the control of the development of ovarian follicles by growth factors and hormones, but less is known about the roles of extracellular matrix in the control of follicular growth and development. In this review we focus on the specialized extracellular matrix of the basal laminas that are present in ovarian follicles. These include the follicular basal lamina itself, the Call-Exner bodies of the membrana granulosa, the subendothelial and arteriole smooth muscle basal laminas in the theca, and the basal lamina-like material of the thecal matrix. We discuss the evidence that during follicle development the follicular basal lamina changes in composition, that many of its components are produced by the granulosa cells, and that the follicular basal laminas of different follicles have different ultrastructural appearances, linked to the shape of the aligning granulosa cells. All these studies suggest that the follicular basal lamina is extremely dynamic during follicular development. PMID:10963877

  18. Anti-mullerian hormone and antral follicle count as predictors of ovarian response in assisted reproduction

    Directory of Open Access Journals (Sweden)

    Y Himabindu

    2013-01-01

    Full Text Available Objective: The objective of this study was to test the hypothesis that AMH and antral follicle count (AFC are good predictors of ovarian response to controlled ovarian stimulation and to compare them. Materials and Methods: This observational cross-sectional study included 56 subjects aged between 25 and 42 years who were enrolled between 1 st January and 31 st December 2010 for their first intracytoplasmic sperm injection (ICSI program. Baseline hormone profiles including serum levels of Estradiol (E2, Follicle-stimulating hormone (FSH, Luteinizing hormone (LH, and Anti-mullerian Hormone (AMH were determined on day 3 of the previous cycle. The antral follicle count measurements were performed on days 3-5 of the same menstrual cycle. Antral follicles within the bilateral ovaries between 2-6 mm were recorded. The subjects were treated with long protocol for ovarian stimulation. Ovulation was induced with 10,000 IU of human chorionic gonadotropin (hCG when at least 3 follicles attained the size of more than 17 mm. Transvaginal oocyte retrieval was performed under ultrasound guidance 36 hours after hCG administration. An oocyte count less than 4 and absence of follicular growth with controlled ovarian hyper stimulation was considered as poor ovarian response. Oocyte count of 4 or more was considered as normal ovarian response. Results: Statistical analysis was performed using SPSS software trail version 16.0. Subjects were divided into 2 groups, depending on the ovarian response. The mean oocyte counts were 12.27 ± 6.06 and 2.22 ± 1.24 in normal and poor responders, respectively, ( P = 001. Multiple regression analysis revealed AMH and antral follicle count as predictors of ovarian response (β coefficient ± SE for AMH was 1.618 ± 0.602 ( P = 0.01 and for AFC, it was, 0.528 ± 0.175 ( P = 0.004. AFC was found to be a better predictor of ovarian response compared to AMH in controlled ovarian hyper stimulation. Conclusion: The observations made

  19. A Lower Rhine flood chronology based on the sedimentary record of an abandoned channel fill

    Science.gov (United States)

    Toonen, W. H. J.; Winkels, T. G.; Prins, M. A.; de Groot, L. V.; Bunnik, F. P. M.; Cohen, K. M.

    2012-04-01

    The Bienener Altrhein is an abandoned channel of the Lower Rhine (Germany). Following a late 16th century abandonment event, the channel was disconnected from the main stream and the oxbow lake gradually filled with 8 meters of flood deposits. This process still continues today. During annual floods, a limited proportion of overbank discharge is routed across the oxbow lake. Large floods produce individual flood layers, which are visually recognized in the sedimentary sequence. Based on the sedimentary characteristics of these event layers, we created a ~450-year flood chronology for the Lower Rhine. Laser-diffraction grain size measurements were used to assess relative flood magnitudes for individual flood event layers. Continuous sampling at a ~2 cm interval provided a high-resolution record, resolving the record at an annual scale. Standard descriptive techniques (e.g., mean grain size, 95th percentile, % sand) and the more advanced 'end member modelling' were applied to zoom in on the coarse particle bins in the grain size distributions, which are indicative of higher flow velocities. The most recent part of the record was equated to modern discharge measurements. This allows to establish relations between deposited grain size characteristics in the abandoned channel and flood magnitudes in the main river. This relation can also be applied on flood event layers from previous centuries, for which only water level measurements and historical descriptions exist. This makes this method relevant to expand data series used in flood frequency analysis from 100 years to more than 400 years. To date event-layers in the rapidly accumulated sequence, we created an age-depth model that uses organic content variations to tune sedimentation rates between the known basal and top ages. No suitable identifiable organic material for radiocarbon dating was found in the cores. Instead, palynological results (introduction of agricultural species) and palaeomagnetic secular

  20. OVARIAN CALCIFICATION MIMICKING VESICLE CALCULUS

    OpenAIRE

    Pallavi; Pratibha; Santosh Kumar; Neeeta; Kamal

    2013-01-01

    INTRODUCTION: Calcification in ovary is usually dystrophic in natu re, forming secondary to degeneration of the epithelium or in association wit h areas of necrosis. It may occur in cases of endometriosis [1] or in some ovarian tumor eg. Fibro thecoma [2] , Brenner’s tumor [3] , cavernous hemangioma [4] etc. Benign unilateral densely calcified ovary wit hout any association with tumor or endometriosis has not been reported previously. We repo...

  1. 20 CFR 416.924b - Age as a factor of evaluation in the sequential evaluation process for children.

    Science.gov (United States)

    2010-04-01

    .... We consider an infant born at less than 37 weeks' gestation to be born prematurely. (1) We apply a... (i.e., the difference between 40 weeks of full-term gestation and the number of actual weeks of gestation) from your chronological age. The result is your corrected chronological age. (ii) If you are...

  2. Rewiring yeast acetate metabolism through MPC1 loss of function leads to mitochondrial damage and decreases chronological lifespan

    Directory of Open Access Journals (Sweden)

    Ivan Orlandi

    2014-11-01

    Full Text Available During growth on fermentable substrates, such as glucose, pyruvate, which is the end-product of glycolysis, can be used to generate acetyl-CoA in the cytosol via acetaldehyde and acetate, or in mitochondria by direct oxidative decarboxylation. In the latter case, the mitochondrial pyruvate carrier (MPC is responsible for pyruvate transport into mitochondrial matrix space. During chronological aging, yeast cells which lack the major structural subunit Mpc1 display a reduced lifespan accompanied by an age-dependent loss of autophagy. Here, we show that the impairment of pyruvate import into mitochondria linked to Mpc1 loss is compensated by a flux redirection of TCA cycle intermediates through the malic enzyme-dependent alternative route. In such a way, the TCA cycle operates in a “branched” fashion to generate pyruvate and is depleted of intermediates. Mutant cells cope with this depletion by increasing the activity of glyoxylate cycle and of the pathway which provides the nucleocytosolic acetyl-CoA. Moreover, cellular respiration decreases and ROS accumulate in the mitochondria which, in turn, undergo severe damage. These acquired traits in concert with the reduced autophagy restrict cell survival of the mpc1∆ mutant during chronological aging. Conversely, the activation of the carnitine shuttle by supplying acetyl-CoA to the mitochondria is sufficient to abrogate the short-lived phenotype of the mutant.

  3. The Association Between Talc Use and Ovarian Cancer: A Retrospective Case–Control Study in Two US States

    OpenAIRE

    Cramer, Daniel W.; Vitonis, Allison F.; Terry, Kathryn L.; Welch, William R.; Titus, Linda J.

    2015-01-01

    Background: Multiple studies of ovarian cancer and genital talc use have led only to consensus about possible carcinogenicity. Seeking greater clarity, we examined this association in 2,041 cases with epithelial ovarian cancer and 2,100 age- and-residence-matched controls. Methods: We defined genital talc use as regular application to the genital/rectal area directly, on sanitary napkins, tampons, or underwear. To estimate “talc-years,” we multiplied applications per year by years used. Uncon...

  4. Use of fertility drugs and risk of ovarian cancer: Danish Population Based Cohort Study

    DEFF Research Database (Denmark)

    Jensen, Allan; Sharif, Heidi; Frederiksen, Kirsten;

    2009-01-01

    OBJECTIVE: To examine the effects of fertility drugs on overall risk of ovarian cancer using data from a large cohort of infertile women. DESIGN: Population based cohort study. SETTING: Danish hospitals and private fertility clinics. PARTICIPANTS: 54,362 women with infertility problems referred to...... confounding factors. RESULTS: Analyses within cohort showed no overall increased risk of ovarian cancer after any use of gonadotrophins (rate ratio 0.83, 95% confidence interval 0.50 to 1.37), clomifene (1.14, 0.79 to 1.64), human chorionic gonadotrophin (0.89, 0.62 to 1.29), or gonadotrophin releasing...... all Danish fertility clinics during 1963-98. The median age at first evaluation of infertility was 30 years (range 16-55 years), and the median age at the end of follow-up was 47 (range 18-81) years. Included in the analysis were 156 women with invasive epithelial ovarian cancer (cases) and 1241...

  5. Cytogenetics of Premature Ovarian Failure: An Investigation on 269 Affected Women

    Directory of Open Access Journals (Sweden)

    Simona Baronchelli

    2011-01-01

    Full Text Available The importance of X chromosome in the aetiology of premature ovarian failure (POF is well-known but in many cases POF still remains idiopathic. Chromosome aneuploidy increase is a physiological phenomenon related to aging, but the role of low-level sex chromosome mosaicism in ovarian function is still undiscovered. Standard cytogenetic analysis was carried out in a total of 269 patients affected by POF: 27 chromosomal abnormalities were identified, including X chromosome and autosomal structural and numerical abnormalities. In 47 patients with 46,XX karyotype we performed interphase FISH using X alpha-satellite probe in order to identify X chromosome mosaicism rate. Aneuploidy rate in the patient group was significantly higher than the general population group. These findings underline the importance of X chromosome in the aetiology of POF and highlight the potential role of low-level sex chromosome mosaicism in ovarian aging that may lead to a premature onset of menopause.

  6. Prevalence of ovarian adrenal rest tumours and polycystic ovaries in females with congenital adrenal hyperplasia: results of ultrasonography and MR imaging

    International Nuclear Information System (INIS)

    The aim of the investigation was to assess the prevalence of ovarian adrenal rest tumours and polycystic ovaries in female patients with congenital adrenal hyperplasia (CAH). Thirteen female CAH patients (median age 19.8 years, range 14.8-23.5 years) underwent transvaginal (n=6) or transabdominal (n=7) ultrasonography by a gynaecologist and MR imaging (n=13) of the ovaries (pre and post contrast-enhanced T1- and T2-weighted images). Ovarian adrenal rest tumours were defined as small hypoechoic and multifocal nodules on ultrasound and isointense lesions on T1- and hypointense on T2-weighted MR images (derived from characteristics of testicular adrenal rest tumours). Polycystic ovaries were defined as the presence of ≥10 follicles arranged peripherally around or scattered throughout increased stroma. No ovarian adrenal rest tumours were found either on ultrasound, or by MR imaging. Polycystic ovaries were found in 2 of the 13 patients (15.4%), both with ultrasound and MR. No ovarian adrenal rest tumours were detected in these female CAH patients, which suggests that ovarian adrenal rest tumours in CAH females are rare. The prevalence of polycystic ovaries corresponded to that in the general population. From these results, we would suggest that routine ovarian imaging in CAH females is not indicated. However, when ovarian dysfunction is present, ovarian imaging is advised, first by ultrasonography, to detect ovarian adrenal rest tumours or polycystic ovaries. (orig.)

  7. Validating genetic risk associations for ovarian cancer through the international Ovarian Cancer Association Consortium

    DEFF Research Database (Denmark)

    Pearce, C L; Near, A M; Van Den Berg, D J;

    2009-01-01

    The search for genetic variants associated with ovarian cancer risk has focused on pathways including sex steroid hormones, DNA repair, and cell cycle control. The Ovarian Cancer Association Consortium (OCAC) identified 10 single-nucleotide polymorphisms (SNPs) in genes in these pathways, which had...... been genotyped by Consortium members and a pooled analysis of these data was conducted. Three of the 10 SNPs showed evidence of an association with ovarian cancer at P... and risk of ovarian cancer suggests that this pathway may be involved in ovarian carcinogenesis. Additional follow-up is warranted....

  8. "EDML1": a chronology for the EPICA deep ice core from Dronning Maud Land, Antarctica, over the last 150 000 years

    Directory of Open Access Journals (Sweden)

    U. Ruth

    2007-08-01

    Full Text Available A chronology called EDML1 has been developed for the EPICA ice core from Dronning Maud Land (EDML. EDML1 is closely interlinked with EDC3, the new chronology for the EPICA ice core from Dome-C (EDC through a stratigraphic match between EDML and EDC that consists of 322 volcanic match points over the last 128 ka. The EDC3 chronology comprises a glaciological model at EDC, which is constrained and later selectively tuned using primary dating information from EDC as well as from EDML, the latter being transferred using the tight stratigraphic link between the two cores. Finally, EDML1 was built by exporting EDC3 to EDML. For ages younger than 41 ka BP the new synchronized time scale EDML1/EDC3 is based on dated volcanic events and on a match to the Greenlandic ice core chronology GICC05 via 10Be and methane. The internal consistency between EDML1 and EDC3 is estimated to be typically ~6 years and always less than 450 years over the last 128 ka (always less than 130 years over the last 60 ka, which reflects an unprecedented synchrony of time scales. EDML1 ends at 150 ka BP (2417 m depth because the match between EDML and EDC becomes ambiguous further down. This hints at a complex ice flow history for the deepest 350 m of the EDML ice core.

  9. A case-control study of risk factors for epithelial ovarian cancer

    Directory of Open Access Journals (Sweden)

    Ghaem Maghami Noori F

    2001-09-01

    Full Text Available Ovarian cancer is second prevalent cancer among gynecologic malignancies and the most common type of ovarian cancer is epithelial form (85-90 percent. To detect the risk factors for the epithelial ovarian cancer, a case-control study was conducted in Valieasr hospital in 1988. In this study, 118 cases with epithelial ovarian cancer (according histological records and 240 controls without any gynecological cancer in gynecologic clinic had been interviewed. For data analysis, T-test, Chi2 test and logistic regression have been used at a =0.05 as level of significance. The mean age in cases was 50±13 and in controls was 49.9±12 years, without significant different. The mean number of pregnancies and parity in cases was less than controls, significantly (P<0.03. The mean months of breast feeding in cases was less than controls (54.9±71.2 versus 82.4±62.7 (P<0.001. The cases had a lower mean age of menarch than controls (P=0.03. 58 percent of cases and 21.3 percent of controls hadn't used any contraception methods (P=0.00001. The mean years of contraception was significantly less in cases versus controls (P<0.001. The odds ratio for epithelial ovarian cancer was 0.24 (95 percent CI: 0.13-0.48 in OCP users, 0.47 (95 percent CI: 0.005-0.43 in TL method, and was 0.41 (95 percent CI: 0.22-0.76 in other contraception methods, relative to women who hadn't used any contraception methods. This study reveals that epithelial ovarian cancer risk increases significantly with earlier menarch, decreasing number of pregnancy, deliveries duration of breast feeding and use of contraception methods. Use of contraception pill and tubal ligation method decreases risk of epithelial ovarian cancer.

  10. Mitochondrial dysfunction increases oxidative stress and decreases chronological life span in fission yeast.

    Directory of Open Access Journals (Sweden)

    Alice Zuin

    Full Text Available BACKGROUND: Oxidative stress is a probable cause of aging and associated diseases. Reactive oxygen species (ROS originate mainly from endogenous sources, namely the mitochondria. METHODOLOGY/PRINCIPAL FINDINGS: We analyzed the effect of aerobic metabolism on oxidative damage in Schizosaccharomyces pombe by global mapping of those genes that are required for growth on both respiratory-proficient media and hydrogen-peroxide-containing fermentable media. Out of a collection of approximately 2700 haploid yeast deletion mutants, 51 were sensitive to both conditions and 19 of these were related to mitochondrial function. Twelve deletion mutants lacked components of the electron transport chain. The growth defects of these mutants can be alleviated by the addition of antioxidants, which points to intrinsic oxidative stress as the origin of the phenotypes observed. These respiration-deficient mutants display elevated steady-state levels of ROS, probably due to enhanced electron leakage from their defective transport chains, which compromises the viability of chronologically-aged cells. CONCLUSION/SIGNIFICANCE: Individual mitochondrial dysfunctions have often been described as the cause of diseases or aging, and our global characterization emphasizes the primacy of oxidative stress in the etiology of such processes.

  11. Paleoseismic investigations in the Kopili Fault Zone of North East India: Evidences from liquefaction chronology

    Science.gov (United States)

    Kumar, Devender; Reddy, D. V.; Pandey, Anand K.

    2016-04-01

    We report the seismogenic liquefaction signatures observed in the Kopili Fault Zone of the Brahmaputra plains, NE India. This seismically active zone has previously been identified as the "Assam seismic gap" and thus necessitates understanding its past seismicity and implied seismic hazard. With this objective, paleo-seismic studies using seismogenic liquefaction features have been carried out in this region largely covered with the flood plain deposits of Kopili and Kalang rivers. The trenches excavated at two locations revealed extensive liquefaction features with more than 20 sub parallel sand dykes having major orientation in NE-SW direction. A total of 29 samples from marker horizons have been processed to constrain chronology of the liquefaction features using optically stimulated luminescence (OSL) and 14C (AMS) dating techniques. The age constraints in terms of respective lower and upper bound age brackets for individual dykes suggest three time intervals of their formations i.e. (i) 250 ± 25 yr. BP, (ii) between 400 to 770 yr. BP and (iii) 900 ± 50 yr. BP. These new ages of liquefaction features correspond to the occurrence timings of causative seismic events which are in addition to the known historical earthquakes and thus enhance our understanding of the paleoseismic history of this region during past ~ 1000 years.

  12. Application of tandem accelerator mass spectrometor to the chronological study of archaeological samples on Ryukyu Islands

    Energy Technology Data Exchange (ETDEWEB)

    Taira, Hatsuo; Higa, Kenichi; Nakai, Nobuyuki; Nakamura, Toshio.

    1987-10-01

    Along with the urbanization of rural areas on Ryukyu Islands, many shell mounds and pre-historic sites have been found in resent years. Chrological studies of shell samples from these mounds will lead to the better understanding of cultural background for the pre-historic human activities on the Ryukyu Islands. C-14 dating by beta counting is the common method to obtain the ages of the archaeological samples. It is, however, very limited in obtaining the absolute ages by the above mehtod due to the large sample sizes required and time consuming. There are many newly obtained archaeological samples left unstudied in detail. The alternate is a method called Tandem Accelerator Mass Spectrometer (AMS) installed at Nagoya University, which is composed of the tandem type accelerator to measure very low concentration of C-14 in archaeological samples. The system has been designed particularly to measure the radio-carbon and has advantages of being small sample size and very little time consuming for C-14 measurement as compared with the beta counting. It is the aim of this work to apply the above AMS for obtaining the absolute ages of the archaeological samples. The results agreed well with those estimated by the Erthenware method (relative method of dating), which ranged from 500 to 6000 y.b.p. The results may be helpful for the chronological arrangement of the samples and for the understanding of pre-historical human activities on the Ryukyu Islands.

  13. Revised stratigraphy and chronology for Homo floresiensis at Liang Bua in Indonesia.

    Science.gov (United States)

    Sutikna, Thomas; Tocheri, Matthew W; Morwood, Michael J; Saptomo, E Wahyu; Jatmiko; Awe, Rokus Due; Wasisto, Sri; Westaway, Kira E; Aubert, Maxime; Li, Bo; Zhao, Jian-xin; Storey, Michael; Alloway, Brent V; Morley, Mike W; Meijer, Hanneke J M; van den Bergh, Gerrit D; Grün, Rainer; Dosseto, Anthony; Brumm, Adam; Jungers, William L; Roberts, Richard G

    2016-04-21

    Homo floresiensis, a primitive hominin species discovered in Late Pleistocene sediments at Liang Bua (Flores, Indonesia), has generated wide interest and scientific debate. A major reason this taxon is controversial is because the H. floresiensis-bearing deposits, which include associated stone artefacts and remains of other extinct endemic fauna, were dated to between about 95 and 12 thousand calendar years (kyr) ago. These ages suggested that H. floresiensis survived until long after modern humans reached Australia by ~50 kyr ago. Here we report new stratigraphic and chronological evidence from Liang Bua that does not support the ages inferred previously for the H. floresiensis holotype (LB1), ~18 thousand calibrated radiocarbon years before present (kyr cal. BP), or the time of last appearance of this species (about 17 or 13-11 kyr cal. BP). Instead, the skeletal remains of H. floresiensis and the deposits containing them are dated to between about 100 and 60 kyr ago, whereas stone artefacts attributable to this species range from about 190 to 50 kyr in age. Whether H. floresiensis survived after 50 kyr ago--potentially encountering modern humans on Flores or other hominins dispersing through southeast Asia, such as Denisovans--is an open question.

  14. Revised stratigraphy and chronology for Homo floresiensis at Liang Bua in Indonesia.

    Science.gov (United States)

    Sutikna, Thomas; Tocheri, Matthew W; Morwood, Michael J; Saptomo, E Wahyu; Jatmiko; Awe, Rokus Due; Wasisto, Sri; Westaway, Kira E; Aubert, Maxime; Li, Bo; Zhao, Jian-xin; Storey, Michael; Alloway, Brent V; Morley, Mike W; Meijer, Hanneke J M; van den Bergh, Gerrit D; Grün, Rainer; Dosseto, Anthony; Brumm, Adam; Jungers, William L; Roberts, Richard G

    2016-04-21

    Homo floresiensis, a primitive hominin species discovered in Late Pleistocene sediments at Liang Bua (Flores, Indonesia), has generated wide interest and scientific debate. A major reason this taxon is controversial is because the H. floresiensis-bearing deposits, which include associated stone artefacts and remains of other extinct endemic fauna, were dated to between about 95 and 12 thousand calendar years (kyr) ago. These ages suggested that H. floresiensis survived until long after modern humans reached Australia by ~50 kyr ago. Here we report new stratigraphic and chronological evidence from Liang Bua that does not support the ages inferred previously for the H. floresiensis holotype (LB1), ~18 thousand calibrated radiocarbon years before present (kyr cal. BP), or the time of last appearance of this species (about 17 or 13-11 kyr cal. BP). Instead, the skeletal remains of H. floresiensis and the deposits containing them are dated to between about 100 and 60 kyr ago, whereas stone artefacts attributable to this species range from about 190 to 50 kyr in age. Whether H. floresiensis survived after 50 kyr ago--potentially encountering modern humans on Flores or other hominins dispersing through southeast Asia, such as Denisovans--is an open question. PMID:27027286

  15. An optical luminescence chronology for late Pleistocene aeolian activity in the Colombian and Venezuelan Llanos

    Science.gov (United States)

    Carr, Andrew S.; Armitage, Simon J.; Berrío, Juan-Carlos; Bilbao, Bibiana A.; Boom, Arnoud

    2016-03-01

    The lowland savannas (Llanos) of Colombia and Venezuela are covered by extensive aeolian landforms for which little chronological information exists. We present the first optically stimulated luminescence (OSL) age constraints for dunes in the Llanos Orientales of lowland Colombia and new ages for dunes in the Venezuelan Llanos. The sampled dunes are fully vegetated and show evidence of post-depositional erosion. Ages range from 4.5 ± 0.4 to 66 ± 4 ka, with the majority dating to 27-10 ka (Marine Isotope Stage 2). Some dunes accumulated quickly during the last glacial maximum, although most were active 16-10 ka. Accretion largely ceased after 10 ka. All dunes are elongated downwind from rivers, parallel with dry season winds, and are interpreted as source-bordering features. As they are presently isolated from fluvial sediments by gallery forest it is proposed that activity was associated with a more prolonged dry season, which restricted gallery forest, leading to greater sediment availability on river shorelines. Such variability in dry season duration was potentially mediated by the mean latitude of the ITCZ. The cessation of most dune accretion after ca. 10 ka suggests reduced seasonality and a more northerly ITCZ position, consistent with evidence from the Cariaco Basin.

  16. Ovarian Tumors in Children and Adolescents: A 10-Yr Histopathologic Review in Korle-Bu Teaching Hospital, Ghana.

    Science.gov (United States)

    Akakpo, Patrick K; Derkyi-Kwarteng, Leonard; Quayson, Solomon E; Gyasi, Richard K; Anim, Jehoram T

    2016-07-01

    To determine the histopathologic types, frequency of occurrence, age distribution, presenting signs, and symptoms of ovarian tumors in children and adolescents diagnosed at the Korle-Bu Teaching Hospital all histopathology slides and request cards of ovarian tumors diagnosed in subjects aged, 0 to 19 yr over a 10-yr period (2001-2010) were reviewed. Biographical and clinical data of the patients were collected. The results were entered into Epi-info to determine the frequency of various ovarian tumors in different age groups and their association with presenting signs and symptoms. A total of 67 (9.5%) ovarian tumors were diagnosed in patients aged 0 to 19 yr of a total of 706 diagnosed in all age groups during the period. The majority [44 (65.7%)] were germ cell tumors, the commonest being mature cystic teratoma. Burkitt lymphoma was the single most common malignant tumor, comprising 6(9%) of all the tumors, although as a group malignant germ cell tumors were still the most common malignant ovarian tumors in children and adolescents. Although germ cell tumors were the most common tumors in this age group (both benign and malignant), Burkitt lymphoma, a peculiar malignant tumor in this subregion, was the single most common malignant tumor of the ovary. PMID:26630227

  17. MV-NIS or Investigator's Choice Chemotherapy in Treating Patients With Ovarian, Fallopian, or Peritoneal Cancer

    Science.gov (United States)

    2016-06-24

    Fallopian Tube Transitional Cell Carcinoma; Malignant Ovarian Clear Cell Tumor; Malignant Ovarian Endometrioid Tumor; Malignant Ovarian Serous Tumor; Ovarian Seromucinous Carcinoma; Ovarian Transitional Cell Carcinoma; Primary Peritoneal Serous Adenocarcinoma; Recurrent Fallopian Tube Carcinoma; Recurrent Ovarian Carcinoma; Recurrent Primary Peritoneal Carcinoma; Undifferentiated Fallopian Tube Carcinoma; Undifferentiated Ovarian Carcinoma

  18. Perceptions of and Attitudes towards Ageing in Zambia

    Science.gov (United States)

    Mapoma, Christopher C.; Masaiti, Gift

    2012-01-01

    This paper reflects part of the wider outlook on ageing in general in Zambia and was intended to investigate perceptions of and attitudes towards the aged and ageing in Zambia by members of the community who, by definition and chronologically are not classified as aged i.e. not yet 60 years and over. Focus Group Discussions (FGD) were used to…

  19. The effect of neighborhood disadvantage on the racial disparity in ovarian cancer-specific survival in a large hospital-based study in Cook County, Illinois

    Directory of Open Access Journals (Sweden)

    Caryn E. Peterson

    2015-01-01

    Full Text Available This paper examines the effect of neighborhood disadvantage on racial disparities in ovarian cancer-specific survival. Despite treatment advances for ovarian cancer, survival remains shorter for African-American compared to White women. Neighborhood disadvantage is implicated in racial disparities across a variety of health outcomes and may contribute to racial disparities in ovarian cancer-specific survival. Data were obtained from 581 women (100 African-American and 481 White diagnosed with epithelial ovarian cancer between June 1, 1994, and December 31, 1998 in Cook County, Illinois, which includes the city of Chicago. Neighborhood disadvantage score at the time of diagnosis was calculated for each woman based on Browning and Cagney’s index of concentrated disadvantage. Cox proportional hazard models measured the association of self-identified African-American race with ovarian cancer-specific survival after adjusting for age, tumor characteristics, surgical debulking, and neighborhood disadvantage. There was a statistically significant negative association (-0.645 between ovarian cancer-specific survival and neighborhood disadvantage (p = 0.008. After adjusting for age and tumor characteristics, African-American women were more likely than Whites to die of ovarian cancer (HR = 1.59, p = 0.003. After accounting for neighborhood disadvantage, this risk was attenuated (HR = 1.32, p = 0.10. These findings demonstrate that neighborhood disadvantage is associated with ovarian cancer-specific survival and may contribute to the racial disparity in survival.

  20. Melatonin, a possible promising panacea for premature ovarian failure

    Directory of Open Access Journals (Sweden)

    Ting Guo

    2011-04-01

    Full Text Available Premature ovarian failure (POF is characterized by impairment of ovarian function unrelated to elevatedfollicle-stimulating hormone (FSH before the age of 40. The consequence of POF is severe and distinctive, presentingfrom infertility to symptoms caused by hormone deprivation. The mechanism of POF remains unclearand current treatments are therefore ineffective. Melatonin (N-acetyl-5-methoxytryptamine is a neuroendocrinalhormone chiefly secreted by the pineal body. Melatonin exerts extensive physiological and pharmacologicaleffects on the biological rhythm, oxidative stress, reproduction, autoimmune and tumourigenesis. However,current researches have not yet brought melatonin into the study of POF. In the present review, we have involvedstate-of-the-art research progress of melatonin in ovary with regard to oxidation, follicle formation and function,and ovarian autoimmune disorders since these aspects mainly dispose to POF development. The features thatmelatonin scavenges reactive oxygen species (ROS, directly and indirectly induces follicle maturation, ovulationand inhibits apoptosis, and modulates autoimmune derangements in the ovaries are highly indicative that melatonincan effect in combating POF. Also, in this respect we have discussed the possibility of applying melatoninin the treatment of POF and have listed evidence of studies in vitro and in vivo. Vacant research directions aresubsequently suggested and the future application of melatonin in POF treatment is prospected.

  1. Endometriosis-Associated Ovarian Cancer: A Review of Pathogenesis

    Directory of Open Access Journals (Sweden)

    Shu-Wing Ng

    2013-03-01

    Full Text Available Endometriosis is classically defined as the presence of endometrial glands and stroma outside of the endometrial lining and uterine musculature. With an estimated frequency of 5%–10% among women of reproductive age, endometriosis is a common gynecologic disorder. While in itself a benign lesion, endometriosis shares several characteristics with invasive cancer, has been shown to undergo malignant transformation, and has been associated with an increased risk of epithelial ovarian carcinoma (EOC. Numerous epidemiologic studies have shown an increased risk of EOC among women with endometriosis. This is particularly true for women with endometrioid and clear cell ovarian carcinoma. However, the carcinogenic pathways by which endometriosis associated ovarian carcinoma (EAOC develops remain poorly understood. Current molecular studies have sought to link endometriosis with EAOC through pathways related to oxidative stress, inflammation and hyperestrogenism. In addition, numerous studies have sought to identify an intermediary lesion between endometriosis and EAOC that may allow for the identification of endometriosis at greatest risk for malignant transformation or for the prevention of malignant transformation of this common gynecologic disorder. The objective of the current article is to review the current data regarding the molecular events associated with EAOC development from endometriosis, with a primary focus on malignancies of the endometrioid and clear cell histologic sub-types.

  2. Revisiting ovarian hyper stimulation syndrome: Towards OHSS free clinic

    Directory of Open Access Journals (Sweden)

    Manish Banker

    2015-01-01

    Full Text Available A rapid development and application of assisted reproductive technologies (ARTs and ovulation-induction drugs may lead to ovarian hyper stimulation syndrome (OHSS. Young age, low body mass index (BMI, polycystic ovarian syndrome (PCOS, previous OHSS, high follicle count, and elevated serum estradiol (E2 are the certain factors that predispose women to OHSS. Many strategies have been used to reduce or avoid OHSS. Use of human chorionic gonadotropin (hCG increases ovarian vascular permeability and is responsible for activating the vascular endothelial growth factors (VEGF pathway and thus the entire cascade, leading to symptomatic OHSS. Gonadotropin-releasing hormone (GnRH agonists are used as a replacement for hCG for final oocyte maturation in antagonist cycles. Reducing or eliminating the use of hCG and use of GnRH agonist triggered GnRH antagonist cycles and cryopreservation of oocytes or embryos is the most promising approach in making OHSS free clinic a reality.

  3. Cigarette smoking and risk of ovarian cancer

    DEFF Research Database (Denmark)

    Faber, Mette T; Kjær, Susanne K; Dehlendorff, Christian;

    2013-01-01

    The majority of previous studies have observed an increased risk of mucinous ovarian tumors associated with cigarette smoking, but the association with other histological types is unclear. In a large pooled analysis, we examined the risk of epithelial ovarian cancer associated with multiple...... measures of cigarette smoking with a focus on characterizing risks according to tumor behavior and histology....

  4. Hormone therapy and different ovarian cancers

    DEFF Research Database (Denmark)

    Mørch, Lina Steinrud; Løkkegaard, Ellen; Andreasen, Anne Helms;

    2012-01-01

    Postmenopausal hormone therapy use increases the risk of ovarian cancer. In the present study, the authors examined the risks of different histologic types of ovarian cancer associated with hormone therapy. Using Danish national registers, the authors identified 909,946 women who were followed fr...

  5. Ovarian cancer mortality and industrial pollution

    International Nuclear Information System (INIS)

    We investigated whether there might be excess ovarian cancer mortality among women residing near Spanish industries, according to different categories of industrial groups and toxic substances. An ecologic study was designed to examine ovarian cancer mortality at a municipal level (period 1997–2006). Population exposure to pollution was estimated by means of distance from town to facility. Using Poisson regression models, we assessed the relative risk of dying from ovarian cancer in zones around installations, and analyzed the effect of industrial groups and pollutant substances. Excess ovarian cancer mortality was detected in the vicinity of all sectors combined, and, principally, near refineries, fertilizers plants, glass production, paper production, food/beverage sector, waste treatment plants, pharmaceutical industry and ceramic. Insofar as substances were concerned, statistically significant associations were observed for installations releasing metals and polycyclic aromatic chemicals. These results support that residing near industries could be a risk factor for ovarian cancer mortality. - Highlights: • We studied excess mortality due to ovarian cancer near Spanish industries. • Integrated nested Laplace approximations were used as a Bayesian inference tool. • We found excess ovarian cancer mortality near all industrial groups as a whole. • Risk also was found in towns near industries releasing carcinogens and metals. • Risk was associated with plants releasing polycyclic aromatic chemicals and POPs. - Our results support that residing in the vicinity of pollutant industries could be a risk factor for ovarian cancer mortality

  6. Hormone therapy and ovarian borderline tumors

    DEFF Research Database (Denmark)

    Mørch, Lina Steinrud; Løkkegaard, Ellen; Andreasen, Anne Helms;

    2012-01-01

    Little is known about the influence of postmenopausal hormone therapy on the risk of ovarian borderline tumors. We aimed at assessing the influence of different hormone therapies on this risk.......Little is known about the influence of postmenopausal hormone therapy on the risk of ovarian borderline tumors. We aimed at assessing the influence of different hormone therapies on this risk....

  7. Aligning and synchronization of MIS5 proxy records from Lake Ohrid (FYROM) with independently dated Mediterranean archives: implications for DEEP core chronology

    Science.gov (United States)

    Zanchetta, Giovanni; Regattieri, Eleonora; Giaccio, Biagio; Wagner, Bernd; Sulpizio, Roberto; Francke, Alex; Vogel, Hendrik; Sadori, Laura; Masi, Alessia; Sinopoli, Gaia; Lacey, Jack H.; Leng, Melanie J.; Leicher, Niklas

    2016-05-01

    The DEEP site sediment sequence obtained during the ICDP SCOPSCO project at Lake Ohrid was dated using tephrostratigraphic information, cyclostratigraphy, and orbital tuning through the marine isotope stages (MIS) 15-1. Although this approach is suitable for the generation of a general chronological framework of the long succession, it is insufficient to resolve more detailed palaeoclimatological questions, such as leads and lags of climate events between marine and terrestrial records or between different regions. Here, we demonstrate how the use of different tie points can affect cyclostratigraphy and orbital tuning for the period between ca. 140 and 70 ka and how the results can be correlated with directly/indirectly radiometrically dated Mediterranean marine and continental proxy records. The alternative age model presented here shows consistent differences with that initially proposed by Francke et al. (2015) for the same interval, in particular at the level of the MIS6-5e transition. According to this new age model, different proxies from the DEEP site sediment record support an increase of temperatures between glacial to interglacial conditions, which is almost synchronous with a rapid increase in sea surface temperature observed in the western Mediterranean. The results show how a detailed study of independent chronological tie points is important to align different records and to highlight asynchronisms of climate events. Moreover, Francke et al. (2016) have incorporated the new chronology proposed for tephra OH-DP-0499 in the final DEEP age model. This has reduced substantially the chronological discrepancies between the DEEP site age model and the model proposed here for the last glacial-interglacial transition.

  8. Stable, Renormalizable, Scalar Tachyonic Quantum Field Theory with Chronology Protection

    CERN Document Server

    Radzikowski, Marek J

    2008-01-01

    We use microlocal arguments to suggest that Lorentz symmetry breaking must occur in a reasonably behaved tachyonic quantum field theory that permits renormalizability. In view of this, we present a scalar tachyonic quantum field model with manifestly broken Lorentz symmetry and without exponentially growing/decaying modes. A notion of causality, in which anti-telephones are excluded, and which is viewed as a form of chronology protection, is obeyed. The field theory is constructed in a preferred tachyon frame in terms of commuting creation/annihilation operators. We calculate some sample (renormalized) operators in this preferred frame, argue that the Hadamard condition is satisfied, and discuss the PCT and spin-statistics theorems for this model.

  9. Ştefania Cristescu-Golopenţia's Chronology

    Directory of Open Access Journals (Sweden)

    SANDA GOLOPENŢIA

    2013-07-01

    Full Text Available The present Chronology brings together data from the personal archive of Şt.C.-G. with data accumulated during the editing of her published and posthumous work that Sanda Golopenţia undertook after 1989. The author specifically calls attention to the new data regarding Şt.C.-G.'s 1938 and 1939 regional research in Ţara Oltului (the Olt County, the research she conducted in 1945 and 1947 in the Gurghiu Valley, and the social inquiry on the daily lives of her students in the Industrial Colege "Protopopul Tudor Economul" from Bucharest (1942-1943. The bibliography of St.C.-G.'s sociological, pedagogical and literary works was updated.

  10. Chronology and origin of VMS deposits in Xinjiang, NW CHINA

    Institute of Scientific and Technical Information of China (English)

    CHEN; Fuwen(陈富文); LI; Huaqin(李华芹); WANG; Denghong(王登红); XIE; Caifu(谢才富); LU; Yuanfa(路远发)

    2002-01-01

    VMS deposits in Xinjiang, NW China are widespread in the Altay, Tianshan and West Kunlun orogenic belt, mainly formed during the Proterozoic rifting and Phanerozoic post-orogenic extension and are related to the bimodal volcanism. The VMS deposits are middle and small in scale. According to assemblages of metallogenetic elements, they can be divided into four types (Cu-Zn, Cu-S, Pb-Zn-Cu and Pb-Zn types) with the Cu-Zn and Pb-Zn types being the most important ones. Research of isotopic chronology shows that the VMS deposits in Xinjiang were formed during the Proterozoic, Ordovician, Deovonian, Carboniferous and Permian periods and usually underwent multi-stage mineralization, especially the large-sized deposits usually have post- volcanic superimposed mineralization by tectonomagmatic or metamorphic hydrothermal metallogenic fluids.

  11. Holographic Protection of Chronology in Universes of the Godel Type

    CERN Document Server

    Boyda, E; Horava, P; Varadarajan, U; Boyda, Edward; Ganguli, Surya; Horava, Petr; Varadarajan, Uday

    2003-01-01

    We analyze the structure of supersymmetric Godel-like cosmological solutions of string theory. Just as the original four-dimensional Godel universe, these solutions represent rotating, topologically trivial cosmologies with a homogeneous metric and closed timelike curves. First we focus on "phenomenological" aspects of holography, and identify the preferred holographic screens associated with inertial comoving observers in Godel universes. We find that holography can serve as a chronology protection agency: The closed timelike curves are either hidden behind the holographic screen, or broken by it into causal pieces. In fact, holography in Godel universes has many features in common with de Sitter space, suggesting that Godel universes could represent a supersymmetric laboratory for addressing the conceptual puzzles of de Sitter holography. Then we initiate the investigation of "microscopic" aspects of holography of Godel universes in string theory. We show that Godel universes are T-dual to pp-waves, and use...

  12. Tephra Deposits in Lake Mead Miocene Sediments: Characteristics, Chronology, and Sources

    Science.gov (United States)

    Dunbar, N. W.; McIntosh, W. C.; Umhoefer, P. J.; Lamb, M. A.; Hickson, T.

    2013-12-01

    The Lake Mead extensional domain, in the east central Basin and Range Province, contains Miocene basin sediments that have undergone complex faulting and deformation. A rich tephra record in the basin sediments provides a chronological and correlation framework that can help understand the depositional and deformational processes during Miocene and post-Miocene time. The tephra layers, up to 10s of cm thick, range from white deposits containing glassy shards to bright green layers in which all original glass has been altered to the zeolite mordenite. The tephra layers range from aphyric to extremely crystal rich. Many appear to be primary ashfall deposits based on depositional geometry, uniform crystal size, and good preservation of glass or relict glass shard structures. However, some layers show evidence of reworking as evidenced by variable crystal size, and the presence of plutonic feldspar and rock fragments. Electron microprobe analyses of preserved glass reveal that compositions of almost all of the tephra layers are high silica rhyolite, typically with FeO and CaO contents of 1wt% or lower. Where present, the glass in the tephra layers is invariably hydrated, consistent with their age, but although the alkali concentrations in the glass are likely to have been modified by the hydration process, other elements, particularly Fe, Ca, Ti, and Cl appear to yield robust concentrations. The compositions of individual layers with respect to these elements are very homogeneous, based on analysis of 20-30 glass shards per sample, and can be used to correlate individual tephra layers between different parts of the sedimentary basin, although a number of layers have very similar compositions. Some higher Fe rhyolites/dacites (up to 4 wt.% FeO) are also observed. Crystal-bearing tephra layers contain some combination of quartz, one or two feldspars (typically a chemically uniform sanidine and a range of plagioclase compositions), biotite, amphibole, and magnetite

  13. Statehood Day or Candlemas Day: Ideology vs. Chronology

    Directory of Open Access Journals (Sweden)

    Srđan Milošević

    2016-03-01

    Full Text Available The paper deals with the ideological and chronological issues concerning Statehood day, which is celebrated on the 15th and 16th of February in Serbia. The focus will be on the connection which is being established between the state holiday of Statehood day and Candlemas Day which is a church holiday. The paper will further deal with the problems with dating the two key events – the start of the First Serbian Uprising in 1804 and the adoption of the first Serbian Constitution in 1835 – which, according to the Serbian law on national and other holidays, form the basis for the celebrating of Statehood day. The paper will prove that it wasn’t necessary for the legislators to insist on establishing a connection between the aforementioned events and the date of the church holiday neither in the 19th nor in the 21st century. The author will also point out the significant errors in chronology: it is falsely claimed that the anniversaries of both these events coincide with Candlemas Day (in 1804 and 1835, respectively, and that it is hence unwarranted to claim that they coincide with Candlemas Day in the 21st century. It will be shown that the reason for these errors lies in the incorrect calculation and translation of dates from the Julian into the Gregorian calendar, as well as that the contemporary insistence on the connection between Statehood day and Candlemas Day is ideologically conditioned and that it is a consequence of the desecularization of Serbian society.

  14. Environmental factors influence lesser scaup migration chronology and population monitoring

    Science.gov (United States)

    Finger, Taylor A.; Afton, Alan D.; Schummer, Michael L.; Petrie, Scott A.; Badzinski, Shannon S.; Johnson, Michael A.; Szymanski, Michael L.; Jacobs, Kevin J.; Olsen, Glenn H.; Mitchell, Mark

    2016-01-01

    Identifying environmental metrics specific to lesser scaup (Aythya affinis; scaup) spring migration chronology may help inform development of conservation, management and population monitoring. Our objective was to determine how environmental conditions influence spring migration of lesser scaup to assess the effectiveness of the Waterfowl Breeding Population and Habitat Survey in accurately estimating scaup populations. We first compared peak timing of mallard (Anas platyrhynchos) and scaup migration from weekly ground surveys in North Dakota, USA because the Waterfowl Breeding Population and Habitat Survey is designed to capture annual mallard migration. As predicted, we detected that peak timing of scaup and mallard migrations differed in 25 of 36 years investigated (1980–2010). We marked scaup with satellite transmitters (n = 78; 7,403 locations) at Long Point, Lake Erie, Ontario, Canada; Pool 19 of the Mississippi River, Iowa and Illinois, USA; and Presque Isle Bay, Lake Erie, Pennsylvania, USA. We tested the assumption that our marked scaup were representative of the continental population using the traditional survey area by comparing timing of migration of marked birds and scaup counted in the North Dakota Game and Fish Department survey. We detected a strong positive correlation between marked scaup and the survey data, which indicated that marked scaup were representative of the population. We subsequently used our validated sample of marked scaup to investigate the effects of annual variation in temperature, precipitation, and ice cover on spring migration chronology in the traditional and eastern survey areas of the Waterfowl Breeding Population and Habitat Survey, 2005–2010. We evaluated competing environmental models to explain variation in timing and rate of scaup migration at large-scale and local levels. Spring migration of scaup occurred earlier and faster during springs with warmer temperatures and greater precipitation, variables known

  15. [Ovarian torsion revealing an ovarian cavernous hemangioma in a child].

    Science.gov (United States)

    M'pemba Loufoua-Lemay, A-B; Peko, J-F; Mbongo, J-A; Mokoko, J-C; Nzingoula, S

    2003-11-01

    The authors report one case of cavernous hemangioma of the left ovary, which was revealed by ovarian torsion. Such benign tumors of the blood vessels are rare in ovaries during childhood. This hemangioma was observed in a 13-year-old patient, who presented with abdominal and pelvic pain and vomiting. The pelvic mass was noted and sonography revealed a cystic tumor. An annexectomia was realized. Histology showed narcotized ovary cells, with an increased number of vascular channels composed of thin walled vessels, whose wall consisted of an endothelium. This aspect evoked a cavernous hemangioma of the ovary. PMID:14613693

  16. A reevaluation of the Pallett Creek earthquake chronology based on new AMS radiocarbon dates, San Andreas fault, California

    Science.gov (United States)

    Scharer, K.M.; Biasi, G.P.; Weldon, R.J.

    2011-01-01

    The Pallett Creek paleoseismic record occupies a keystone position in most attempts to develop rupture histories for the southern San Andreas fault. Previous estimates of earthquake ages at Pallett Creek were determined by decay counting radiocarbon methods. That method requires large samples which can lead to unaccounted sources of uncertainty in radiocarbon ages because of the heterogeneous composition of organic layers. In contrast, accelerator mass spectrometry (AMS) radiocarbon dates may be obtained from small samples that have known carbon sources and also allow for a more complete sampling of the section. We present 65 new AMS radiocarbon dates that span nine ground-rupturing earthquakes at Pallett Creek. Overall, the AMS dates are similar to and reveal no dramatic bias in the conventional dates. For many layers, however, individual charcoal samples were younger than the conventional dates, leading to earthquake ages that are overall slightly younger than previously reported. New earthquake ages are determined by Bayesian refinement of the layer ages based on stratigraphic ordering and sedimentological constraints. The new chronology is more regular than previously published records in large part due to new samples constraining the age of event R. The closed interval from event C to 1857 has a mean recurrence of 135years (?? = 83.2 years) and a quasiperiodic coefficient of variation (COV) of 0.61. We show that the new dates and resultant earthquake chronology have a stronger effect on COV than the specific membership of this long series and dating precision improvements from sedimentation rates. Copyright 2011 by the American Geophysical Union.

  17. TELL SABI ABYAD, SYRIA : RADIOCARBON CHRONOLOGY, CULTURAL CHANGE, AND THE 8.2 KA EVENT

    NARCIS (Netherlands)

    van der Plicht, J.; Akkermans, P. M. M. G.; Nieuwenhuyse, O.; Kaneda, A.; Russell, A.

    2011-01-01

    At Tell Sabi Abyad, Syria, we obtained a robust chronology for the 7th to early 6th millennium BC, the Late Neolithic. The chronology was obtained using a large set of radiocarbon dates, analyzed by Bayesian statistics. Cultural changes observed at similar to 6200 BC are coeval with the 8.2 ka clima

  18. An 854-Year Tree-Ring Chronology of Scots Pine for South-West Finland

    Directory of Open Access Journals (Sweden)

    Helama Samuli

    2014-04-01

    Full Text Available A near-millennial tree-ring chronology (AD 1147-2000 is presented for south-west Finland and analyzed using dendroclimatic methods. This is a composite chronology comprising samples both from standing pine trees (Pinus sylvestris L. and subfossil trunks as recovered from the lake sediments, with a total sample size of 189 tree-ring sample series. The series were dendrochronologically cross-dated to exact calendar years to portray variability in tree-ring widths on inter-annual and longer scales. Al though the studied chronology correlates statistically significantly with other long tree-ring width chronologies from Finland over their common period (AD 1520-1993, the south-west chronology did not exhibit similarly strong mid-summer temperature or spring/early-summer precipitation signals in comparison to published chronologies. On the other hand, the south-west chronology showed highest correlations to the North Atlantic Oscillation indices in winter/spring months, this association following a dendroclimatic feature common to pine chronologies over the region and adjacent areas. Paleoclimatic comparison showed that tree-rings had varied similarly to central European spring temperatures. It is postulated that the collected and dated tree-ring material could be studied for wood surface reflectance (blue channel light intensity and stable isotopes, which both have recently shown to correlate notably well with summer temperatures.

  19. Targeted Therapies in Epithelial Ovarian Cancer

    Directory of Open Access Journals (Sweden)

    Jurjees Hasan

    2010-02-01

    Full Text Available Molecularly targeted therapy is relatively new to ovarian cancer despite the unquestionable success with these agents in other solid tumours such as breast and colorectal cancer. Advanced ovarian cancer is chemosensitive and patients can survive several years on treatment. However chemotherapy diminishes in efficacy over time whilst toxicities persist. Newer biological agents that target explicit molecular pathways and lack specific chemotherapy toxicities such as myelosuppression offer the advantage of long-term therapy with a manageable toxicity profile enabling patients to enjoy a good quality of life. In this review we appraise the emerging data on novel targeted therapies in ovarian cancer. We discuss the role of these compounds in the front-line treatment of ovarian cancer and in relapsed disease; and describe how the development of predictive clinical, molecular and imaging biomarkers will define the role of biological agents in the treatment of ovarian cancer.

  20. Targeted Therapies in Epithelial Ovarian Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Dean, Emma; El-Helw, Loaie; Hasan, Jurjees, E-mail: jurjees.hasan@christie.nhs.uk [Christie Hospital NHS Foundation Trust / Wilmslow Road, Manchester, M20 4BX (United Kingdom)

    2010-02-23

    Molecularly targeted therapy is relatively new to ovarian cancer despite the unquestionable success with these agents in other solid tumours such as breast and colorectal cancer. Advanced ovarian cancer is chemosensitive and patients can survive several years on treatment. However chemotherapy diminishes in efficacy over time whilst toxicities persist. Newer biological agents that target explicit molecular pathways and lack specific chemotherapy toxicities such as myelosuppression offer the advantage of long-term therapy with a manageable toxicity profile enabling patients to enjoy a good quality of life. In this review we appraise the emerging data on novel targeted therapies in ovarian cancer. We discuss the role of these compounds in the front-line treatment of ovarian cancer and in relapsed disease; and describe how the development of predictive clinical, molecular and imaging biomarkers will define the role of biological agents in the treatment of ovarian cancer.

  1. Ovarian cancer mortality and industrial pollution.

    Science.gov (United States)

    García-Pérez, Javier; Lope, Virginia; López-Abente, Gonzalo; González-Sánchez, Mario; Fernández-Navarro, Pablo

    2015-10-01

    We investigated whether there might be excess ovarian cancer mortality among women residing near Spanish industries, according to different categories of industrial groups and toxic substances. An ecologic study was designed to examine ovarian cancer mortality at a municipal level (period 1997-2006). Population exposure to pollution was estimated by means of distance from town to facility. Using Poisson regression models, we assessed the relative risk of dying from ovarian cancer in zones around installations, and analyzed the effect of industrial groups and pollutant substances. Excess ovarian cancer mortality was detected in the vicinity of all sectors combined, and, principally, near refineries, fertilizers plants, glass production, paper production, food/beverage sector, waste treatment plants, pharmaceutical industry and ceramic. Insofar as substances were concerned, statistically significant associations were observed for installations releasing metals and polycyclic aromatic chemicals. These results support that residing near industries could be a risk factor for ovarian cancer mortality. PMID:26046426

  2. OVARIAN METASTASIS IN PATIENT WITH ENDOMETRIAL CARCINOMA

    Institute of Scientific and Technical Information of China (English)

    ZHOU Feng-zhi; CHEN Yi-nan; ZHANG Guo-nan

    2005-01-01

    Objective: To study the clinical pathological characteristics of ovarian metastasis of endometrial carcinoma and the factors affecting prognosis. Methods: Retrospective analysis was made to the clinical pathological outcome of endometrial carcinoma patients receiving surgical treatment in our hospital from January 1990 to December 2002. Results:Among the 191 cases of endometrial carcinoma patients, 17 cases (8.9%) had ovarian metastasis and young patients were more likely to have ovarian metastasis. The multiple factor analysis showed that the independent risk factors of ovarian metastasis in endometrial carcinoma included the depth of myometrial invasion, lymph node metastasis and pathological types. Conclusion: Ovarian metastasis in patients with endometrial carcinoma is associated with poor prognosis, the depth of myometrial invasion, lymph node metastasis and histologic types are independent risk factors affecting the prognosis. For young patients at early stage of the disease, it should be prudent as to whether to retain the ovary.

  3. Genetic profiles distinguish different types of hereditary ovarian cancer

    DEFF Research Database (Denmark)

    Domanska, Katarina; Malander, Susanne; Staaf, Johan;

    2010-01-01

    Heredity represents the strongest risk factor for ovarian cancer with disease predisposing mutations identified in 15% of the tumors. With the aim to identify genetic classifiers for hereditary ovarian cancer, we profiled hereditary ovarian cancers linked to the hereditary breast and ovarian canc...

  4. Oncolytic reovirus against ovarian and colon cancer.

    Science.gov (United States)

    Hirasawa, Kensuke; Nishikawa, Sandra G; Norman, Kara L; Alain, Tommy; Kossakowska, Anna; Lee, Patrick W K

    2002-03-15

    Reovirus selectively replicates in and destroys cancer cells with an activated Ras signaling pathway. In this study, we evaluated the feasibility of using reovirus (serotype 3, strain Dearing) as an antihuman colon and ovarian cancer agent. In in vitro studies, reovirus infection in human colon and ovarian cell lines was assessed by cytopathic effect as detected by light microscopy, [(35)S]Methionine labeling of infected cells for viral protein synthesis and progeny virus production by plaque assay. We observed that reovirus efficiently infected all five human colon cancer cell lines (Caco-2, DLD-1, HCT-116, HT-29, and SW48) and four human ovarian cancer cell lines (MDAH2774, PA-1, SKOV3, and SW626) which were tested, but not a normal colon cell line (CCD-18Co) or a normal ovarian cell line (NOV-31). We also observed that the Ras activity in the human colon and ovarian cancer cell lines was elevated compared with that in normal colon and ovarian cell lines. In animal models, intraneoplastic as well as i.v. inoculation of reovirus resulted in significant regression of established s.c. human colon and ovarian tumors implanted at the hind flank. Histological studies revealed that reovirus infection in vivo was restricted to tumor cells, whereas the surrounding normal tissue remained uninfected. Additionally, in an i.p. human ovarian cancer xenograft model, inhibition of ascites tumor formation and the survival of animals treated with live reovirus was significantly greater than of control mice treated with UV-inactivated reovirus. Reovirus infection in ex vivo primary human ovarian tumor surgical samples was also confirmed, further demonstrating the potential of reovirus therapy. These results suggest that reovirus holds promise as a novel agent for human colon and ovarian cancer therapy. PMID:11912142

  5. Aligning MIS5 proxy records from Lake Ohrid (FYROM with independently dated Mediterranean archives: implications for core chronology

    Directory of Open Access Journals (Sweden)

    G. Zanchetta

    2015-10-01

    Full Text Available The DEEP site sediment sequence obtained during the ICDP SCOPSCO project at Lake Ohrid was dated using tephrostratigraphic information, cyclostratigraphy, and orbital tuning through marine isotope record. Although this approach is suitable for the generation of a general chronological framework of the long succession, it is insufficient to resolve more detailed paleoclimatological questions, such as leads and lags of climate events between marine and terrestrial records or between different regions. In this paper, we demonstrate how the use of different tie points can affect cyclostratigraphy and orbital tuning for the period between ca. 140 and 70 ka and how the results can be correlated with directly/indirectly radiometrically-dated Mediterranean marine and continental proxy records. The alternative age model obtained shows consistent differences with that proposed by Francke et al. (2015 for the same interval, in particular at the level of the MIS6-5e transition. According to this age model, different proxies from the DEEP site sediment record support an increase of temperatures between glacial to interglacial conditions, which is almost synchronous with a rapid increase in sea surface temperature observed in the western Mediterranean. The results show how important a detailed study of independent chronological tie points is for synchronizing different records and to highlight asynchronisms of climate events.

  6. Aligning MIS5 proxy records from Lake Ohrid (FYROM) with independently dated Mediterranean archives: implications for core chronology

    Science.gov (United States)

    Zanchetta, G.; Regattieri, E.; Giaccio, B.; Wagner, B.; Sulpizio, R.; Francke, A.; Vogel, L. H.; Sadori, L.; Masi, A.; Sinopoli, G.; Lacey, J. H.; Leng, M. L.; Leicher, N.

    2015-10-01

    The DEEP site sediment sequence obtained during the ICDP SCOPSCO project at Lake Ohrid was dated using tephrostratigraphic information, cyclostratigraphy, and orbital tuning through marine isotope record. Although this approach is suitable for the generation of a general chronological framework of the long succession, it is insufficient to resolve more detailed paleoclimatological questions, such as leads and lags of climate events between marine and terrestrial records or between different regions. In this paper, we demonstrate how the use of different tie points can affect cyclostratigraphy and orbital tuning for the period between ca. 140 and 70 ka and how the results can be correlated with directly/indirectly radiometrically-dated Mediterranean marine and continental proxy records. The alternative age model obtained shows consistent differences with that proposed by Francke et al. (2015) for the same interval, in particular at the level of the MIS6-5e transition. According to this age model, different proxies from the DEEP site sediment record support an increase of temperatures between glacial to interglacial conditions, which is almost synchronous with a rapid increase in sea surface temperature observed in the western Mediterranean. The results show how important a detailed study of independent chronological tie points is for synchronizing different records and to highlight asynchronisms of climate events.

  7. HORMONAL INFLUENCES ON THE OVARIAN FUNCTION AND THE IMPLANTATION PROCESS IN GUINEA PIGS

    Institute of Scientific and Technical Information of China (English)

    LIUCheng-Quan; DAIMao-Zheng; SHENShu-Ren; WANGZhong-Xing

    1989-01-01

    The influence of peptides and steroid hormones on ovarian function and implantation was studied in guinea pigs. Results show that injections of 5ng LHRH in pulses of onc-hour interval 10 times per day, starting from 20-30 days of age, could induce the first vaginal

  8. 77 FR 41791 - Proposed Collection; Comment Request; Prostate, Lung, Colorectal and Ovarian Cancer Screening...

    Science.gov (United States)

    2012-07-16

    ... designed to determine if cancer screening for prostate, lung, colorectal, and ovarian cancer can reduce... design is a two-armed randomized trial of men and women aged 55 to 74 at entry. OMB first approved this... Supplemental Questionnaire is being replaced with the Medication Use Questionnaire. As PLCO participants...

  9. Physical activity and risk of ovarian cancer: Results from the Netherlands Cohort Study (The Netherlands)

    NARCIS (Netherlands)

    Biesma, R.G.; Schouten, L.J.; Dirx, M.J.M.; Goldbohm, R.A.; Brandt, P.A. van den

    2006-01-01

    Objective: To investigate the association between nonoccupational physical activity and the risk of ovarian cancer among post-menopausal women. Methods: The Netherlands Cohort Study on Diet and Cancer consists of 62,573 women aged 55-69 years at baseline. Information regarding baseline nonoccupation

  10. The impact in older women of ovarian FMR1 genotypes and sub-genotypes on ovarian reserve.

    Directory of Open Access Journals (Sweden)

    Norbert Gleicher

    Full Text Available We recently associated ovarian FMR1genotypes and sub-genotypes with distinct ovarian aging patterns. How they impact older females is, however, unknown. We, therefore, investigated 217 consecutive first in vitro fertilization (IVF cycles in women >40 assessing oocyte yields, stratified for better (anti-Müllerian hormone, AMH >1.05 ng/mL or poorer (AMH ≤ 1.05 ng/mL functional reserve (FOR. Mean age was 42.4 ± 2.0 years, mean AMH 0.76 ± 0.92 ng/mL and mean oocyte yield 5.3 ± 5.4. Overall, and in women with better FOR, FMR1 did not affect oocyte yields. With poorer FOR (AMH ≤ 1.05 ng/mL women with het-norm/high, however, demonstrated higher oocyte yields (5.0 ± 3.8 than those with het-norm/low sub-genotype 3.1 ± 2.5; P = 0.03, confirmed after log conversion. Known associated with low FOR at young age, het-norm/high, thus, appears to preserve FOR into older age, and both het sub-genotypes appear to expand female reproductive lifespan into opposite directions.

  11. Application of OSL and 10Be techniques to the establishment of deglaciation chronology in Estonia

    International Nuclear Information System (INIS)

    The deglaciation history of Estonia has been under research for about a century. Despite the great number of publications devoted to this subject and marked improvements in study methods, many problems of topical interest have not been solved yet, especially due to the lack of good direct dating methods. In this paper the suitability of OSL and 10Be dating techniques for establishing accurate deglaciation chronology for Estonia is assessed. Turbidity and water depth, velocity of outwash streams and transport length, possible fast sedimentation at night hours or below the ice, incorporation of older, unbleached particles, and other factors affected the extent of the bleaching of the TL signal in different ways, causing great variability of dates. Surface inclination, height of the surface over ground, snow and vegetation cover, and evolution of water bodies influenced the calculation of reliable exposure ages of objects dated using the 10Be method. It means that age determinations of both glaciofluvial deposits with the OSL method and erratic boulders with the 1Be method are highly problematic, especially for glaciofluvial intertill sediments where the exact genesis of deposits is unknown and for boulders, which have been in the forest, under the waters of proglacial lakes and/or the Baltic Sea, or under snow cover for a long time. (author)

  12. Chronology of the stratum containing the skull of the Dali Man

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The field investigations of geomorphology and Quaternary sediment sequences show that the sediment stratigraphic profile containing the skull of the Homo sapiens Daliensis (Dali Man) at Tianshuigou trench, Jiefang Village (109°44′E, 34°52′N ), Dali County, Shaanxi Province, is composed of the loess-paleosol sequence, 17.3 m thick, in the upper part, and the alluvial silts, fine sands and sandy gravels interbedded, 15.4 m thick, in the lower part. There are the well developed layers L1, S1, L2 and S2 in the loess-paleosol sequence of the profile, which are comparable to those of the Luochuan loess section on the basis of magnetic succeptibility measurements and IRSL dating of the loess samples. An alluvial gravel layer, where the skull of the Dali Man was discovered, is in 13 m beneath the bottom of paleosol S2, implying that, the age of the Dali Man must be older than about 247 kaBP when the paleosol S2 began to be developed. The samples of mammal animal tooth and shell fossils from the gravel layer containing the skull of the Dali Man have been dated by uranium series and ESR methods respectively. Based on the multiple dating results and the stratigraphic chronology, the age of the Dali Man, therefore, would be estimated as older than 250 kaBP and younger than 350 kaBP, and reasonably estimated as 260-300 kaBP.

  13. The EDC3 chronology for the EPICA Dome C ice core

    Directory of Open Access Journals (Sweden)

    F. Parrenin

    2007-03-01

    Full Text Available The EPICA (European Project for Ice Coring in Antarctica Dome C drilling in East Antarctica has now been completed to a depth of 3260 m, at only a few meters above bedrock. Here we present the new official EDC3 chronology, which is based on the use of 1 a snow accumulation and mechanical flow model, and 2 a set of independent age markers along the core. These are obtained by pattern matching of recorded parameters to either absolutely dated paleoclimatic records, or to insolation variations. We show that this new time scale is in excellent agreement with the Dome Fuji and Vostok ice core time scales back to 100 kyr within 1 kyr. Discrepancies larger than 3 kyr arise during MIS 5.4, 5.5 and 6, which points to anomalies in either snow accumulation or mechanical flow during these time periods. We estimate that EDC3 gives accurate event durations within 20% (2σ back to MIS11 and accurate absolute ages with a maximum uncertainty of 6 kyr back to 800 kyr.

  14. The EDC3 chronology for the EPICA Dome C ice core

    Directory of Open Access Journals (Sweden)

    F. Parrenin

    2007-08-01

    Full Text Available The EPICA (European Project for Ice Coring in Antarctica Dome C drilling in East Antarctica has now been completed to a depth of 3260 m, at only a few meters above bedrock. Here we present the new EDC3 chronology, which is based on the use of 1 a snow accumulation and mechanical flow model, and 2 a set of independent age markers along the core. These are obtained by pattern matching of recorded parameters to either absolutely dated paleoclimatic records, or to insolation variations. We show that this new time scale is in excellent agreement with the Dome Fuji and Vostok ice core time scales back to 100 kyr within 1 kyr. Discrepancies larger than 3 kyr arise during MIS 5.4, 5.5 and 6, which points to anomalies in either snow accumulation or mechanical flow during these time periods. We estimate that EDC3 gives accurate event durations within 20% (2σ back to MIS11 and accurate absolute ages with a maximum uncertainty of 6 kyr back to 800 kyr.

  15. OVARIAN CALCIFICATION MIMICKING VESICLE CALCULUS

    Directory of Open Access Journals (Sweden)

    Pallavi

    2013-04-01

    Full Text Available INTRODUCTION: Calcification in ovary is usually dystrophic in natu re, forming secondary to degeneration of the epithelium or in association wit h areas of necrosis. It may occur in cases of endometriosis [1] or in some ovarian tumor eg. Fibro thecoma [2] , Brenner’s tumor [3] , cavernous hemangioma [4] etc. Benign unilateral densely calcified ovary wit hout any association with tumor or endometriosis has not been reported previously. We report a case of heavily calcified left ovary which mimicked as vesicle calculus on X- ray leading to confusion in diagnosis.

  16. Multivariate Analysis of Reproductive Risk Factors for Ovarian Cancer in Alexandria, Egypt

    International Nuclear Information System (INIS)

    Background: Ovarian cancer is the eighth leading cancer in women, as it accounts for 4% of all malignant tumors in females. The incidence of ovarian cancer is up to 10 times higher in western countries than in rural Asian and Africa ones. Different reproductive characteristics, life styles and specific medical conditions are responsible for different pattern and incidence of ovarian cancer worldwide. Material and Methods: A case control study was conducted during the time period from 2000 to 2003 including 172 cases of epithelial ovarian cancer, recently diagnosed and confirmed by histopathology. The patients were accessed at the hospitals currently covered by Alexandria Cancer Registry. In addition, 441 control subjects, comparable by age and address, were randomly selected from patients admitted to the same hospitals for non gynecological, non endocrinal acute diseases. Both cases and controls were subjected to a specific predesigned questionnaire to cover menstrual, reproductive and lifestyle indicators. Univariate and multivariate analysis were conducted and 5% level of significance was adopted. Results: Significantly increased risks were reported with increased number of abortions and increased number of ovarian cycles (OR=1.8, 95% CI (1.7-2.8), and 2.8, 95% CI 2.8 (1.5-5.2), respectively. Similarly, high risks were also reported for increased number of pregnancies, OR= 1.6, 95% CI 1.1-2.4) for I to three pregnancies and 4.2,95% CI 1.2-15.9) for more than four pregnancies On the other hand, decreased risks were reported for those with increased parity compared to nulliparous. Conclusion: Although ovarian cancer is less frequent in our community, yet the significant positive and negative associations between risk factors and ovarian cancer were similar to the results of other studies, apart from the primary prevention program that should be outlined according to prevalence of significant risk factors in the studied local community

  17. The TP73 gene polymorphism (rs4648551, A>G is associated with diminished ovarian reserve.

    Directory of Open Access Journals (Sweden)

    Laura Diniz Vagnini

    Full Text Available It's known that the members of the TP53 family are involved in the regulation of female reproduction. Studies in mice showed that the TP73 gene (member of this family plays a role in the size of follicular pool, ovulation rate and maintenance of genomic stability. In the present study we analyzed data from 605 patients with ≤ 37 years attending their first intracytoplasmic sperm injection (ICSI. The association between the TP73 polymorphism (rs4648551, A>G and the following parameters related to ovarian reserve, like age, antral follicular count (AFC, anti-Mullerian hormone levels (AMH and ovarian response prediction index (ORPI was evaluated. Our results showed an association of the AA genotype with diminished ovarian reserve (AMH <1, AFC ≤9. Women presenting the AA genotype had a 2.0-fold increased risk for having AMH <1 and AFC ≤9 (OR 2.0, 95% CI 1.23-3.31, P = 0.005. Patients presenting AA genotype had the lowest levels of AMH (P = 0.02, the lowest number of antral follicles (P = 0.01 and the lowest ORPI (P = 0.007. Analyzing the alleles, we can see an enrichment of the A allele in the group of diminished ovarian reserve (OR 1.4, 95%CI 1.02-1.83, P = 0.04. To the best of our knowledge, the present study is the first to analyze this polymorphism in humans for assessing the numbers of ovarian follicles and AMH levels and, therefore, the ovarian reserve. Our findings can contribute to the use of this polymorphism as a potential marker of diminished ovarian reserve.

  18. Telocytes as potential targets in a cyclophosphamide-induced animal model of premature ovarian failure.

    Science.gov (United States)

    Liu, Te; Wang, Suwei; Li, Qiong; Huang, Yongyi; Chen, Chuan; Zheng, Jin

    2016-09-01

    Premature ovarian failure (POF) refers to the presence of ovarian atrophic permanent amenorrhea in women under the age of 40. The pathogenesis of POF remains to be fully elucidated. Telocytes are a group of specialized cells with a small cell volume and very long cytoplasmic prolongations with dichotomous branching. Previous studies have indicated that telocytes function to support the trachea and serve as stem cell niches. Although it has been confirmed that telocytes are present in numerous organs in mammals, it remains to be determined whether they are present in ovarian tissues and whether they are involved in the development of POF. The present study used a cyclophosphamide-induced mouse model of POF. Hematoxylin and eosin staining and an enzyme‑linked immunosorbent assay revealed that cyclophosphamide induced edema and apoptosis of ovarian stromal and granulosa cells and increased atretic follicles. In addition, cyclophosphamide induced abnormal peripheral blood FSH and E2 levels in mice. Transmission electron microscopy revealed a small number of telocyte‑like cell structures in the ovarian stroma of wild‑type mice. In addition, flow cytometry and immunohistochemical staining results suggested that the number of cluster of differentiation (CD)34/platelet‑derived growth factor receptor (PDGFR)α, CD34/PDGFRβ and CD34/vimentin double‑positive cells in the ovaries of POF mice was significantly decreased compared with wild‑type mice. In conclusion, mouse ovarian tissues appear to contain telocytes, and cyclophosphamide treatment significantly reduced the number of ovarian telocytes. Therefore, telocytes may serve as a potential novel marker of POF induced by cyclophosphamide. PMID:27485835

  19. Handbook for Instruction on Aging in California Public Schools. Kindergarten Through Grade Twelve.

    Science.gov (United States)

    California State Dept. of Education, Sacramento.

    This handbook is designed to assist teachers at the elementary and secondary level in the development of curricula on aging which can integrate the concepts of aging into ongoing lesson plans. The five content areas of instruction include chronological aging, physiological and biological aging, sociocultural aspects of aging, psychological aging,…

  20. 20 CFR 416.963 - Your age as a vocational factor.

    Science.gov (United States)

    2010-04-01

    ... retirement age (age 60 or older). See § 416.968(d)(4). (f) Information about your age. We will usually not... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Your age as a vocational factor. 416.963... age as a vocational factor. (a) General. “Age” means your chronological age. When we decide...