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Sample records for chronic radiation exposure

  1. Effects in Plant Populations Resulting from Chronic Radiation Exposure

    Energy Technology Data Exchange (ETDEWEB)

    Geras' kin, Stanislav A.; Volkova, Polina Yu.; Vasiliyev, Denis V.; Dikareva, Nina S.; Oudalova, Alla A. [Russian Institute of Agricultural Radiology and Agroecology, 249032, Obninsk (Russian Federation)

    2014-07-01

    environment activates genetic mechanisms, changing a population's resistance to exposure. However, there are ecological situations in which enhanced resistance has not evolved or has not persisted. Consequently, there are good theoretical and practical reasons for more attention being paid to the mechanisms by which populations becomes more radioresistant and to those situations where radio-adaptation appears not to be taking place. Since radio-adaptation plays an important role in response of populations on radiation exposure, this process needs to be incorporated into management programmes. To this very day, the effects of chronic exposure on living organisms and populations remain poorly explored, and represent a much needed field of research. In spite of the long history of the research, we are still far from complete understanding underlying processes in exposed populations. Neglecting field-collected data in favour of simplified short-term experiments that tend to overestimate adverse effects will obviously have detrimental effect for understanding, predicting, and mitigating consequences of the radiation impact on the environment. Much more is to be elucidated in our understanding before we will be able to give an objective and comprehensive assessment of the biological consequences of chronic, low-level radiation exposures to natural plant and animal populations. (authors)

  2. Late health effects of chronic radiation exposure of bone marrow

    Energy Technology Data Exchange (ETDEWEB)

    Yarmoshenko, Ilia V.; Malinovsky, Georgy P.; Konshina, Lidia G.; Zhukovsky, Michael V. [Institute of Industrial Ecology UB RAS, 620219, 20, Sophy Kovalevskoy St., Ekaterinburg (Russian Federation); Tuzankina, Irina A. [Institute of Immunology and Physiology UB RAS, 620049, 106, Pervomayskaya St., Ekaterinburg (Russian Federation)

    2014-07-01

    infectious etiology, which are unexpected due to low doses absorbed in those organs and tissues. To analyze the unexpected results recent findings on strong attributability of stomach, liver and cervix cancers to bacterial and viral infections was taken into account. According to IARC, stomach cancer relative risk associated with helicobacter pillory is 5.6, liver cancer relative risks associated with HBV and HCV are 23 and 17 respectively, cervix cancer relative risk associated with HPV is >100. At the same time association of lung cancer, colon cancer and some other common malignancies with infections is either not established or of low significance. To explain observed effects we suggested that excess mortality due to cancer and non-cancer diseases of infectious etiology is associated with radiation exposure of bone marrow due to Sr-90. Irradiation of hematopoietic stem cells and progenitor cells damages hematopoiesis and suppresses the immune response. Secondary immune deficiency induced by chronic radiation increases susceptibility to the bacterial and viral infections. Such late effect of radiation exposure can be considered within the concept of deterministic tissue reactions. (Under support of UB RAS project 12-P-2-1033). (authors)

  3. Late health effects of chronic radiation exposure of bone marrow

    International Nuclear Information System (INIS)

    etiology, which are unexpected due to low doses absorbed in those organs and tissues. To analyze the unexpected results recent findings on strong attributability of stomach, liver and cervix cancers to bacterial and viral infections was taken into account. According to IARC, stomach cancer relative risk associated with helicobacter pillory is 5.6, liver cancer relative risks associated with HBV and HCV are 23 and 17 respectively, cervix cancer relative risk associated with HPV is >100. At the same time association of lung cancer, colon cancer and some other common malignancies with infections is either not established or of low significance. To explain observed effects we suggested that excess mortality due to cancer and non-cancer diseases of infectious etiology is associated with radiation exposure of bone marrow due to Sr-90. Irradiation of hematopoietic stem cells and progenitor cells damages hematopoiesis and suppresses the immune response. Secondary immune deficiency induced by chronic radiation increases susceptibility to the bacterial and viral infections. Such late effect of radiation exposure can be considered within the concept of deterministic tissue reactions. (Under support of UB RAS project 12-P-2-1033). (authors)

  4. Cytogenetic studies in workers with chronic occupational radiation exposure

    International Nuclear Information System (INIS)

    The technique of chromosomal aberration detection on peripheral lymphocytes blood samples from monazite industry workers was used to study the cytogenetic effect of low chronic radiation doses. Cells from 51 workers and 21 controls were analysed. Cytogenetic data from individuals from different working areas were statistically compared among themselves and with the control group. The possible correlations between chromosomal aberration frequencies and cumulative external dose and working time were investigated. The influence of smoking was also tested. The link to the wives spontaneous abortions was analysed. Our results indicate possible biological effects on this sample of workers. (author)

  5. Modelling the effects of ionizing radiation on survival of animal population: acute versus chronic exposure.

    Science.gov (United States)

    Kryshev, A I; Sazykina, T G

    2015-03-01

    The objective of the present paper was application of a model, which was originally developed to simulate chronic ionizing radiation effects in a generic isolated population, to the case of acute exposure, and comparison of the dynamic features of radiation effects on the population survival in cases of acute and chronic exposure. Two modes of exposure were considered: acute exposure (2-35 Gy) and chronic lifetime exposure with the same integrated dose. Calculations were made for a generic mice population; however, the model can be applied for other animals with proper selection of parameter values. In case of acute exposure, in the range 2-11 Gy, the population response was in two phases. During a first phase, there was a depletion in population survival; the second phase was a recovery period due to reparation of damage and biosynthesis of new biomass. Model predictions indicate that a generic mice population, living in ideal conditions, has the potential for recovery (within a mouse lifetime period) from acute exposure with dose up to 10-11 Gy, i.e., the population may recover from doses above an LD50 (6.2 Gy). Following acute doses above 14 Gy, however, the mice population went to extinction without recovery. In contrast, under chronic lifetime exposures (500 days), radiation had little effect on population survival up to integrated doses of 14-15 Gy, so the survival of a population subjected to chronic exposure was much better compared with that after an acute exposure with the same dose. Due to the effect of "wasted radiation", the integrated dose of chronic exposure could be about two times higher than acute dose, producing the same effect on survival. It is concluded that the developed generic population model including the repair of radiation damage can be applied both to acute and chronic modes of exposure; results of calculations for generic mice population are in qualitative agreement with published data on radiation effects in mice. PMID

  6. Reaction of fresh water zooplankton community to chronic radiation exposure

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    Osipov, D.; Pryakhin, E. [Urals Research Center for Radiation Medicine - URCRM (Russian Federation); Ivanov, I. [FSUE Mayak PA (Russian Federation)

    2014-07-01

    The characteristic features of ecological community as a whole and cenosis of zooplankton organisms as part of it determine the intensity of the processes of self-purification of water and the formation of a particular body of water. Identifying features of the structure and composition of the zooplankton community of aquatic ecosystems exposed to different levels of radiation exposure, it is necessary to identify patterns of changes in zooplankton and hydro-biocenosis as a whole. Industrial reservoirs, the storage of liquid low-level radioactive waste 'Mayak' for decades, have high radiation load. A large range of levels of radioactive contamination (total volume beta-activity in water varies from 2.2x10{sup 3} to 2.3x10{sup 7} Bq/l, total volume alpha-activity - from 2.6x10{sup -1} to 3.1x10{sup 3} Bq/l) provides a unique opportunity to study ecosystems in a number of reservoirs with increasing impact of radiation factor. We studied five reservoirs that were used as the storage of low-and intermediate-level liquid radioactive waste pond and one comparison water body. In parallel with zooplankton sampling water samples were collected for hydro-chemical analysis. 41 indicators were analysed in order to assess the water chemistry. To determine the content of radionuclides in the various components of the ecosystem samples were collected from water, bottom sediments and plankton. Sampling of zooplankton for the quantitative analysis was performed using the method of weighted average auto bathometer. Apshteyn's plankton net of the surface horizon was used for qualitative analysis of the species composition of zooplankton. Software package ERICA Assessment Tool 2012 was used for the calculation of the absorbed dose rate. Species diversity and biomass of zooplankton, the share of rotifers in the number of species, abundance and biomass decrease with the increase of the absorbed dose rate and salinity. The number of species in a sample decreases with the

  7. Ways of pharmacological prophylaxis of stochastic and deterministic effects of chronical radiation exposure

    International Nuclear Information System (INIS)

    The prophylactics of late effects of exposure is the actual medico-social problem, because now there are large groups of persons who were exposed during occupational contact and living on territories contaminated by radionuclides. Most probable consequences of external and internal chronic influence of radiation may be the increase of malignant tumour frequency, the development of secondary myelo- and immuno-depressions, the earlier forming of sclerous and destructive processes, and the acceleration of senescence. The role of damages in immune system was not yet understood in pathogenesis of the late effects of radiation, but there are evidences that the decreasing of the immunologic supervision in period of forming the consequences of radiation influence enables to realize the cancerogenic effect of radiation. The purposes of this investigation are to decrease the frequency or to prevent the development of radiation consequences dangerous for health and life by using the method of modification of radiogenic damages in hemopoietic and immune systems by applying the pharmacological preparations with immunomodulating effects. The investigation tasks include: the study of modifying influence of pharmacological substances with different mechanisms of effect: myelopid (immunomodulating, and regulatory), β-carotin, Calendula officinalis (immunomodulating, and antioxidant), lipamid (detoxicating); the separate or complex applications of these substances; and the development of the optimum medico-prophylactic schemes. The advantages of these indicated preparations in comparison with the known (T-activin, thymogen, cytokines, etc.) are the absence of contraindications and the possibility to use per os. (author)

  8. Analysis of dose-rate effects on cellular responses to chronic radiation exposure

    International Nuclear Information System (INIS)

    The effects in the title were studied on their expression of various genes concerned with radiation exposure by the acute (1 Gy/min) and chronic (0.007-0.694 Gy/min) irradiations to various cell lines. Cell of human origin were the primarily cultured fibroblasts (F), their immortalized strain (imF) by transduction of human teromerase transcriptase (hTERT), breast cancer MCF-7, osteosarcoma U-20S, colon cancer HCT-116 and T-cell leukemia Jurkat. Acute irradiation was done in a gamma-cell with Cs-137 gamma-ray and chronic one, in a CO2-incubator with the Cs-137 source. Expression of genes was analyzed by mRNA sequence with Genome Analyzer. Proteins of p53, p53-Ser15-P, murine double minute 2 (MDM2), p21 and a/b-tubulin were analyzed by Western blotting. D0 values of acute irradiation were found in the range of 1.1-1.4 Gy, suggesting the similar sensitivity of used cells. However, responses to chronic exposure were different from cells to cells: particularly, at 0.347 mGy/min, no effect on growth was observed in cancer-derived cells until 10 days whereas a marked growth inhibition of F and imF cells was seen after 4 days. Arrest of proliferation of F cells after 10 days exposure at 0.347 mGy/min was tentative, but at 0.694 mGy/min, it was irreversible dependently on the exposure time. They were arrested at G0 stage. Gene expression analyzed by mRNA sequence was shown to be changed even by the lowest rate 0.007 mGy/min: levels of protein expressed under control of cancer-suppressing p53 were markedly altered. Western blotting showed an increased expression of examined proteins except for p53, at higher dose than 0.069 mGy/min. Results indicated that the cellular response to radiation involved not only DNA damage but also the process of yielding the damage. (T.T.)

  9. Chronic exposure to gamma radiation of wild populations of meadow voles (Microtus pennsylvanicus)

    International Nuclear Information System (INIS)

    Free-ranging, wild meadow voles (Microtus pennsylvanicus) were exposed to gamma radiation from a 137Cs irradiator in a series of experiments conducted on six 1-ha meadows within a mixed deciduous forest in Manitoba, Canada. Over a period of 1-1.5 years in each of three experiments, vole populations were monitored with capture-mark-release techniques at nominal exposure rates of 200x, 9000x and 40,000x background. No effects on population or individual characteristics were detected up to the highest exposure rate (81 mGy/d). At this level, third generation voles were monitored up to a lifetime dose of about 5.7 Gy, at a measured dose rate of 44 mGy/d. Smaller numbers of overwintered animals survived and reproduced normally at doses up to 10 Gy. These results are discussed in terms of low-LET, external chronic radiation effects on rodents in the laboratory and the field, relative to current views on appropriate benchmarks for the protection of biota

  10. Decision-making about chronic radiation exposure to the public. New recommendations from the ICRP

    International Nuclear Information System (INIS)

    The paper discusses decision-making in situations of chronic exposure within the framework of a forthcoming related ICRP report on the subject which has been produced by an ICRP Task Group chaired by the author. This ICRP report will provide guidance on the application of the ICRP System of Radiological Protection to prolonged exposure situations afflicting members of the public. It will address the general application of the System to the control of prolonged exposures resulting from practices and to the undertaking of interventions in prolonged exposure situations, and will provide recommendations on generic reference levels for such interventions. It will also consider some specific situations and will discuss a number of issues that have been of concern, namely: natural radiation sources that may give rise to high doses; the restoration and rehabilitation of sites where human activities involving radioactive substances have been carried out; the return to 'normality' following an accident that has released radioactive substances to the environment; and the global marketing of commodities for public consumption that contain relatively high levels of radioactive substances. Annexes will provide some examples of prolonged exposure situations and will discuss the radiological protection quantities, radiation-induced health effects and aspects of the System of Radiological Protection relevant to prolonged exposure. The quantitative recommendations for prolonged exposures provided in the report will be as follows: generic reference levels for intervention, in terms of existing annual doses, of < or approx. 100 mSv, above which intervention is almost always justifiable (situations for which the annual dose threshold for deterministic effects in relevant organs is exceeded will almost always require intervention), and of < or approx.10 mSv, below which intervention is not likely to be justifiable (and above which it may be necessary); intervention exemption levels for

  11. Developmental effects induced by chronic and prolonged exposure of chicken embryos to 900 MHz GSM base station radiation

    International Nuclear Information System (INIS)

    Interference from base station radiation with embryonic development was investigated by chronic and prolonged exposure of developing chicken embryos. The latter were exposed under a 900 MHz GSM base station radiating microwaves at recommended safety level, i.e., 41 V/m. Total death rate was 7.7 times higher among radiation exposed embryos (78.5%) than among sham exposures (10.2%). Radiation exposure was associated with delayed hatching (3.2 days) and slightly but significantly increased (P<0.01) weight of hatchings. These finding indicated that base station radiation can induce lethal effect, as well as developmental retardation. They arouse questioning as to the adequacy of current safety guidelines. (author)

  12. Modelling the propagation of effects of chronic exposure to ionising radiation from individuals to populations

    Energy Technology Data Exchange (ETDEWEB)

    Alonzo, F. [Laboratory of Environmental Modelling, DEI/SECRE/LME, Institute of Radioprotection and Nuclear Safety (IRSN), Cadarache, Building 159, BP3, 13115 St-Paul-lez-Durance Cedex (France); Laboratory of Radioecology and Ecotoxicology, DEI/SECRE/LRE, Institute of Radioprotection and Nuclear Safety (IRSN), Cadarache Building 186, BP3, 13115 St-Paul-lez-Durance Cedex (France)], E-mail: frederic.alonzo@irsn.fr; Hertel-Aas, T. [Department of Plant and Environmental Sciences, P.O. Box 5003, Norwegian University of Life Sciences, 1432 Aas (Norway); Gilek, M. [School of Life Sciences, Soedertoern University College, 14189 Huddinge (Sweden); Gilbin, R. [Laboratory of Radioecology and Ecotoxicology, DEI/SECRE/LRE, Institute of Radioprotection and Nuclear Safety (IRSN), Cadarache Building 186, BP3, 13115 St-Paul-lez-Durance Cedex (France); Oughton, D.H. [Department of Plant and Environmental Sciences, P.O. Box 5003, Norwegian University of Life Sciences, 1432 Aas (Norway); Garnier-Laplace, J. [Laboratory of Radioecology and Ecotoxicology, DEI/SECRE/LRE, Institute of Radioprotection and Nuclear Safety (IRSN), Cadarache Building 186, BP3, 13115 St-Paul-lez-Durance Cedex (France)

    2008-09-15

    This study evaluated the potential effect of ionising radiation on population growth using simple population models and parameter values derived from chronic exposure experiments in two invertebrate species with contrasting life-history strategies. In the earthworm Eisenia fetida, models predicted increasing delay in population growth with increasing gamma dose rate (up to 0.6 generation times at 11 mGy h{sup -1}). Population extinction was predicted at 43 mGy h{sup -1}. In the microcrustacean Daphnia magna, models predicted increasing delay in population growth with increasing alpha dose rate (up to 0.8 generation times at 15.0 mGy h{sup -1}), only after two successive generations were exposed. The study examined population effects of changes in different individual endpoints (including survival, number of offspring produced and time to first reproduction). Models showed that the two species did not respond equally to equivalent levels of change, the fast growing daphnids being more susceptible to reduction in fecundity or delay in reproduction than the slow growing earthworms. This suggested that susceptibility of a population to ionising radiation cannot be considered independent of the species' life history.

  13. Effects of chronic exposure to ionising radiation in the Pacific oyster Crassostrea gigas

    International Nuclear Information System (INIS)

    The Cotentin peninsula (Normandy, France) hosts nuclear industry facilities which operate with controlled discharges of radionuclides in the marine environment. Compared to natural radioactivity, the increase by artificial radionuclides is small but constant. As a consequence, marine species are chronically exposed to low additional doses of ionizing radiation (IR). The effects of chronic exposure to radionuclides were investigated in early stages of development of the Japanese oyster Crassostrea gigas. On the basis of literature, mollusks are expected to be particularly resistant to acute IR (UNSCEAR, 1996. Sources and effects of ionizing radiation. Report to the General Assembly, with Scientific Annex. 86 p). Two different chronic exposure conditions consisted in external (137Cs) and internal (241Am) irradiation for two weeks. Biological endpoints were analyzed in parallel at both the integrated (growth) and molecular (target stress gene expression) levels. To identify potential biological targets of IR, oysters were first exposed to very high dose rates and radionuclide activities with the perspective to reduce the levels and to derive dose-response curves. Although the initial exposure levels (137Cs 30 000 μGy.h-1; 241Am 57 000 Bq.L-1) were many orders of magnitude higher than those encountered in the natural environment, no significant change in the measured parameters was observed. This result was surprising because data from the literature showed that exposure of mussel Mytilus edulis to 3H at lower doses rates (10-100 μGy.h-1) induced DNA damage in hemocytes (Jha et al., 2005. Impact of low doses of tritium on the marine mussel, Mytilus edulis: Genotoxic effects and tissue-specific bioconcentration. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 586, 47-57). To understand this apparent discrepancy between those two filtering bivalves, a new experiment was performed to compare the response of oyster exposed to 3H in the same condition

  14. Effects of chronic exposure to ionising radiation in the Pacific oyster Crassostrea gigas

    Energy Technology Data Exchange (ETDEWEB)

    Fievet, B.; Devos, A.; Voiseux, C.; Leconte-Pradines, C. [Institut de Radioprotection et de Surete' Nucleaire (France); Dallas, L.; Jha, A. [University of Plymouth (United Kingdom)

    2014-07-01

    The Cotentin peninsula (Normandy, France) hosts nuclear industry facilities which operate with controlled discharges of radionuclides in the marine environment. Compared to natural radioactivity, the increase by artificial radionuclides is small but constant. As a consequence, marine species are chronically exposed to low additional doses of ionizing radiation (IR). The effects of chronic exposure to radionuclides were investigated in early stages of development of the Japanese oyster Crassostrea gigas. On the basis of literature, mollusks are expected to be particularly resistant to acute IR (UNSCEAR, 1996. Sources and effects of ionizing radiation. Report to the General Assembly, with Scientific Annex. 86 p). Two different chronic exposure conditions consisted in external ({sup 137}Cs) and internal ({sup 241}Am) irradiation for two weeks. Biological endpoints were analyzed in parallel at both the integrated (growth) and molecular (target stress gene expression) levels. To identify potential biological targets of IR, oysters were first exposed to very high dose rates and radionuclide activities with the perspective to reduce the levels and to derive dose-response curves. Although the initial exposure levels ({sup 137}Cs 30 000 μGy.h{sup -1}; {sup 241}Am 57 000 Bq.L{sup -1}) were many orders of magnitude higher than those encountered in the natural environment, no significant change in the measured parameters was observed. This result was surprising because data from the literature showed that exposure of mussel Mytilus edulis to {sup 3}H at lower doses rates (10-100 μGy.h{sup -1}) induced DNA damage in hemocytes (Jha et al., 2005. Impact of low doses of tritium on the marine mussel, Mytilus edulis: Genotoxic effects and tissue-specific bioconcentration. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 586, 47-57). To understand this apparent discrepancy between those two filtering bivalves, a new experiment was performed to compare the response

  15. Evaluation of the genotoxic effects of chronic low-dose ionizing radiation exposure on nuclear medicine workers

    International Nuclear Information System (INIS)

    Introduction: Nuclear medicine workers are occupationally exposed to chronic ionizing radiation. It is known that ionizing radiation may have damaging effects on chromosomes. In the present study, we investigated the genotoxic effects of ionizing radiation on nuclear medicine workers. We used two different indicators of genotoxicity methods: sister chromatid exchange (SCE) and micronucleus (MN). Methods: The present research was carried out using 21 nuclear medicine workers (11 females and 10 males) during two periods: during normal working conditions and after a 1-month vacation. The radiation dose varied from 1.20 to 48.56 mSv, which accumulated during the occupational exposure time between two vacations. Peripheral blood samples were taken from each subject for two distinct lymphocyte cultures (SCE and MN) in each period. Results: In nearly all subjects, SCE values increased significantly during radiation exposure compared to the postvacation period (P<.05). Similarly, MN frequencies in most of the subjects increased significantly during radiation exposure compared to the postvacation period (P<.05). Conclusions: This study revealed that both SCE and MN frequencies in most of the subjects were significantly higher during exposure to ionizing radiation than after a 1-month vacation period. However, this genotoxic effect was reversible in most of the subjects.

  16. Estimation of doses to patients with chronic radiation sickness from external occupational exposure

    International Nuclear Information System (INIS)

    The doses to patients with chronic radiation sickness who had engaged in diagnostic radiology have been estimated according to the radiation work load, type and capacity of X-ray equipment, protection conditions, data of nationwide survey on doses to X-ray workers in China, or the data of dose monitoring in working places. Based on the activities of radium sources, time taken up in performing radium therapy, distance to radium sources and radiation work load, the doses to patients who had engaged in radium therapy have been estimated. The results of estimated average doses for 29 cases of chronic radiation sickness are given. Their average red marrow dose, trunk dose and effective dose equivalent are 1.3 Gy, 1.2 Gy and 1.6 Sv, respectively

  17. Injury to the blood-testis barrier after low-dose-rate chronic radiation exposure in mice

    International Nuclear Information System (INIS)

    Exposure to ionising radiation induces male infertility, accompanied by increasing permeability of the blood-testis barrier. However, the effect on male fertility by low-dose-rate chronic radiation has not been investigated. In this study, the effects of low-dose-rate chronic radiation on male mice were investigated by measuring the levels of tight-junction-associated proteins (ZO-1 and occludin-1), Niemann-Pick disease type 2 protein (NPC-2) and anti-sperm antibody (AsAb) in serum. BALB/c mice were exposed to low-dose-rate radiation (3.49 mGy h-1) for total exposures of 0.02 (6 h), 0.17 (2 d) and 1.7 Gy (21 d). Based on histological examination, the diameter and epithelial depth of seminiferous tubules were significantly decreased in 1.7-Gy-irradiated mice. Compared with those of the non-irradiated group, 1.7-Gy-irradiated mice showed significantly decreased ZO-1, occludin-1 and NPC-2 protein levels, accompanied with increased serum AsAb levels. These results suggest potential blood-testis barrier injury and immune infertility in male mice exposed to low-dose-rate chronic radiation. (authors)

  18. Therapeutic and space radiation exposure of mouse brain causes impaired DNA repair response and premature senescence by chronic oxidant production.

    Science.gov (United States)

    Suman, Shubhankar; Rodriguez, Olga C; Winters, Thomas A; Fornace, Albert J; Albanese, Chris; Datta, Kamal

    2013-08-01

    Despite recent epidemiological evidences linking radiation exposure and a number of human ailments including cancer, mechanistic understanding of how radiation inflicts long-term changes in cerebral cortex, which regulates important neuronal functions, remains obscure. The current study dissects molecular events relevant to pathology in cerebral cortex of 6 to 8 weeks old female C57BL/6J mice two and twelve months after exposure to a γ radiation dose (2 Gy) commonly employed in fractionated radiotherapy. For a comparative study, effects of 1.6 Gy heavy ion 56Fe radiation on cerebral cortex were also investigated, which has implications for space exploration. Radiation exposure was associated with increased chronic oxidative stress, oxidative DNA damage, lipid peroxidation, and apoptosis. These results when considered with decreased cortical thickness, activation of cell-cycle arrest pathway, and inhibition of DNA double strand break repair factors led us to conclude to our knowledge for the first time that radiation caused aging-like pathology in cerebral cortical cells and changes after heavy ion radiation were more pronounced than γ radiation. PMID:23928451

  19. Plants experiencing chronic internal exposure to ionizing radiation exhibit higher frequency of homologous recombination than acutely irradiated plants

    Energy Technology Data Exchange (ETDEWEB)

    Kovalchuk, O.; Kovalchuk, I.; Hohn, B. [Friedrich Miescher Institute, P.O. Box 2543, CH-4002 Basel (Switzerland); Arkhipov, A. [Chernobyl Scientific and Technical Center of International Research, Shkolnaya Str. 6, 255620 Chernobyl (Ukraine); Barylyak, I.; Karachov, I. [Ukrainian Scientific Genetics Center, Popudrenko Str. 50, 253660 Kiev (Ukraine); Titov, V. [Ivano-Frankivsk State Medical Academy, Galitska Str.2, 284000 Ivano-Frankivsk (Ukraine)

    2000-04-03

    Ionizing radiation (IR) is a known mutagen responsible for causing DNA strand breaks in all living organisms. Strand breaks thus created can be repaired by different mechanisms, including homologous recombination (HR), one of the key mechanisms maintaining genome stability [A. Britt, DNA damage and repair in plants, Annu. Rev. Plant. Phys. Plant Mol. Biol., 45 (1996) 75-100; H. Puchta, B. Hohn, From centiMorgans to basepairs: homologous recombination in plants, Trends Plant Sci., 1 (1996) 340-348.]. Acute or chronic exposure to IR may have different influences on the genome integrity. Although in a radioactively contaminated environment plants are mostly exposed to chronic pollution, evaluation of both kinds of influences is important. Estimation of the frequency of HR in the exposed plants may serve as an indication of genome stability. We used previously generated Arabidopsis thaliana and Nicotiana tabacum plants, transgenic for non-active versions of the {beta}-glucoronidase gene (uidA) [P. Swoboda, S. Gal, B. Hohn, H. Puchta, Intrachromosomal homologous recombination in whole plants, EMBO J., 13 (1994) 484-489; H. Puchta, P. Swoboda, B. Hohn, Induction of homologous DNA recombination in whole plants, Plant, 7 (1995) 203-210.] serving as a recombination substrate, to study the influence of acute and chronic exposure to IR on the level of HR as example of genome stability in plants. Exposure of seeds and seedlings to 0.1 to 10.0 Gy 60Co resulted in increased HR frequency, although the effect was more pronounced in seedlings. For the study of the influence of chronic exposure to IR, plants were grown on two chemically different types of soils, each artificially contaminated with equal amounts of 137Cs. We observed a strong and significant correlation between the frequency of HR in plants, the radioactivity of the soil samples and the doses of radiation absorbed by plants (in all cases r0.9, n=6, P<0.05). In addition, we noted that plants grown in soils with

  20. Plants experiencing chronic internal exposure to ionizing radiation exhibit higher frequency of homologous recombination than acutely irradiated plants

    International Nuclear Information System (INIS)

    Ionizing radiation (IR) is a known mutagen responsible for causing DNA strand breaks in all living organisms. Strand breaks thus created can be repaired by different mechanisms, including homologous recombination (HR), one of the key mechanisms maintaining genome stability [A. Britt, DNA damage and repair in plants, Annu. Rev. Plant. Phys. Plant Mol. Biol., 45 (1996) 75-100; H. Puchta, B. Hohn, From centiMorgans to basepairs: homologous recombination in plants, Trends Plant Sci., 1 (1996) 340-348.]. Acute or chronic exposure to IR may have different influences on the genome integrity. Although in a radioactively contaminated environment plants are mostly exposed to chronic pollution, evaluation of both kinds of influences is important. Estimation of the frequency of HR in the exposed plants may serve as an indication of genome stability. We used previously generated Arabidopsis thaliana and Nicotiana tabacum plants, transgenic for non-active versions of the β-glucoronidase gene (uidA) [P. Swoboda, S. Gal, B. Hohn, H. Puchta, Intrachromosomal homologous recombination in whole plants, EMBO J., 13 (1994) 484-489; H. Puchta, P. Swoboda, B. Hohn, Induction of homologous DNA recombination in whole plants, Plant, 7 (1995) 203-210.] serving as a recombination substrate, to study the influence of acute and chronic exposure to IR on the level of HR as example of genome stability in plants. Exposure of seeds and seedlings to 0.1 to 10.0 Gy 60Co resulted in increased HR frequency, although the effect was more pronounced in seedlings. For the study of the influence of chronic exposure to IR, plants were grown on two chemically different types of soils, each artificially contaminated with equal amounts of 137Cs. We observed a strong and significant correlation between the frequency of HR in plants, the radioactivity of the soil samples and the doses of radiation absorbed by plants (in all cases r0.9, n=6, P<0.05). In addition, we noted that plants grown in soils with different

  1. Ionizing radiation exposures in treatments of solid neoplasms are not associated with subsequent increased risks of chronic lymphocytic leukemia.

    Science.gov (United States)

    Radivoyevitch, Tomas; Sachs, Rainer K; Gale, Robert Peter; Smith, Mitchell R; Hill, Brian T

    2016-04-01

    Exposure to ionizing radiation is not thought to cause chronic lymphocytic leukemia (CLL). Challenging this notion are recent data suggesting CLL incidence may be increased by radiation exposure from the atomic bombs (after many decades), uranium mining and nuclear power facility accidents. To assess the effects of therapeutic ionizing radiation for the treatment of solid neoplasms we studied CLL risks in data from the Surveillance, Epidemiology, and End Results (SEER) Program. Specifically, we compared the risks of developing CLL in persons with a 1(st) non-hematologic cancer treated with or without ionizing radiation. We controlled for early detection effects on CLL risk induced by surveillance after 1(st) cancer diagnoses by forming all-time cumulative CLL relative risks (RR). We estimate such CLL RR to be 1.20 (95% confidence interval, 1.17, 1.23) for persons whose 1(st) cancer was not treated with ionizing radiation and 1.00 (0.96, 1.05) for persons whose 1(st) cancer was treated with ionizing radiations. These results imply that diagnosis of a solid neoplasm is associated with an increased risk of developing CLL only in persons whose 1(st) cancer was not treated with radiation therapy. PMID:26922774

  2. Effects of combined exposure of F344 rats to radiation and chronically inhaled cigarette smoke

    International Nuclear Information System (INIS)

    Nuclear workers may be exposed to radiation in various forms, such as low-LET γ-irradiation or α-irradiation from inhaled 239PuO2 particles. These workers may then have increased risk for lung cancer compared to the general population. Of additional concern is the possibility that interactions between radiation and other carcinogens may increase the risk of cancer induction, compared to the risks from either type of agent alone. An important and common lung carcinogen is cigarette smoke. The purpose of this project is to better determine the combined effects of chronically inhaled cigarette smoke and either inhaled 239PuO2 or external, thoracic X-irradiation on the induction of lung cancer in rats. Histologic and dosimetric evaluations of rats in the CS + 239PuO2 study continue, and the study of CS + X rays is beginning

  3. Effects of combined exposure of F344 rats to radiation and chronically inhaled cigarette smoke

    Energy Technology Data Exchange (ETDEWEB)

    Finch, G.L.; Nikula, K.J.; Barr, E.B. [and others

    1995-12-01

    Nuclear workers may be exposed to radiation in various forms, such as low-LET {gamma}-irradiation or {alpha}-irradiation from inhaled {sup 239}PuO{sub 2} particles. These workers may then have increased risk for lung cancer compared to the general population. Of additional concern is the possibility that interactions between radiation and other carcinogens may increase the risk of cancer induction, compared to the risks from either type of agent alone. An important and common lung carcinogen is cigarette smoke. The purpose of this project is to better determine the combined effects of chronically inhaled cigarette smoke and either inhaled {sup 239}PuO{sub 2} or external, thoracic X-irradiation on the induction of lung cancer in rats. Histologic and dosimetric evaluations of rats in the CS + {sup 239}PuO{sub 2} study continue, and the study of CS + X rays is beginning.

  4. Cancer and non-cancer brain and eye effects of chronic low-dose ionizing radiation exposure

    Directory of Open Access Journals (Sweden)

    Picano Eugenio

    2012-04-01

    Full Text Available Abstract Background According to a fundamental law of radiobiology (“Law of Bergonié and Tribondeau”, 1906, the brain is a paradigm of a highly differentiated organ with low mitotic activity, and is thus radio-resistant. This assumption has been challenged by recent evidence discussed in the present review. Results Ionizing radiation is an established environmental cause of brain cancer. Although direct evidence is lacking in contemporary fluoroscopy due to obvious sample size limitation, limited follow-up time and lack of focused research, anecdotal reports of clusters have appeared in the literature, raising the suspicion that brain cancer may be a professional disease of interventional cardiologists. In addition, although terminally differentiated neurons have reduced or mild proliferative capacity, and are therefore not regarded as critical radiation targets, adult neurogenesis occurs in the dentate gyrus of the hippocampus and the olfactory bulb, and is important for mood, learning/memory and normal olfactory function, whose impairment is a recognized early biomarker of neurodegenerative diseases. The head doses involved in radiotherapy are high, usually above 2 Sv, whereas the low-dose range of professional exposure typically involves lifetime cumulative whole-body exposure in the low-dose range of Conclusions At this point, a systematic assessment of brain (cancer and non-cancer effects of chronic low-dose radiation exposure in interventional cardiologists and staff is needed.

  5. Cancer and non-cancer brain and eye effects of chronic low-dose ionizing radiation exposure

    International Nuclear Information System (INIS)

    According to a fundamental law of radiobiology (“Law of Bergonié and Tribondeau”, 1906), the brain is a paradigm of a highly differentiated organ with low mitotic activity, and is thus radio-resistant. This assumption has been challenged by recent evidence discussed in the present review. Ionizing radiation is an established environmental cause of brain cancer. Although direct evidence is lacking in contemporary fluoroscopy due to obvious sample size limitation, limited follow-up time and lack of focused research, anecdotal reports of clusters have appeared in the literature, raising the suspicion that brain cancer may be a professional disease of interventional cardiologists. In addition, although terminally differentiated neurons have reduced or mild proliferative capacity, and are therefore not regarded as critical radiation targets, adult neurogenesis occurs in the dentate gyrus of the hippocampus and the olfactory bulb, and is important for mood, learning/memory and normal olfactory function, whose impairment is a recognized early biomarker of neurodegenerative diseases. The head doses involved in radiotherapy are high, usually above 2 Sv, whereas the low-dose range of professional exposure typically involves lifetime cumulative whole-body exposure in the low-dose range of < 200 mSv, but with head exposure which may (in absence of protection) arrive at a head equivalent dose of 1 to 3 Sv after a professional lifetime (corresponding to a brain equivalent dose around 500 mSv). At this point, a systematic assessment of brain (cancer and non-cancer) effects of chronic low-dose radiation exposure in interventional cardiologists and staff is needed

  6. Combined exposure to simulated microgravity and acute or chronic radiation reduces neuronal network integrity and cell survival

    Science.gov (United States)

    Benotmane, Rafi

    During orbital or interplanetary space flights, astronauts are exposed to cosmic radiations and microgravity. This study aimed at assessing the effect of these combined conditions on neuronal network density, cell morphology and survival, using well-connected mouse cortical neuron cultures. To this end, neurons were exposed to acute low and high doses of low LET (X-rays) radiation or to chronic low dose-rate of high LET neutron irradiation (Californium-252), under the simulated microgravity generated by the Random Positioning Machine (RPM, Dutch space). High content image analysis of cortical neurons positive for the neuronal marker βIII-tubulin unveiled a reduced neuronal network integrity and connectivity, and an altered cell morphology after exposure to acute/chronic radiation or to simulated microgravity. Additionally, in both conditions, a defect in DNA-repair efficiency was revealed by an increased number of γH2AX-positive foci, as well as an increased number of Annexin V-positive apoptotic neurons. Of interest, when combining both simulated space conditions, we noted a synergistic effect on neuronal network density, neuronal morphology, cell survival and DNA repair. Furthermore, these observations are in agreement with preliminary gene expression data, revealing modulations in cytoskeletal and apoptosis-related genes after exposure to simulated microgravity. In conclusion, the observed in vitro changes in neuronal network integrity and cell survival induced by space simulated conditions provide us with mechanistic understanding to evaluate health risks and the development of countermeasures to prevent neurological disorders in astronauts over long-term space travels. Acknowledgements: This work is supported partly by the EU-FP7 projects CEREBRAD (n° 295552)

  7. Chronic radiation syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Akleyev, Alexander V. [Urals Research Centre for Radiation Medicine, Chelyabinsk (Russian Federation). Clinical Dept.

    2014-04-01

    Comprehensive analysis of chronic radiation syndrome, covering epidemiology, pathogenesis, pathoanatomy, diagnosis and treatment. Based on observations in a unique sample of exposed residents of the Techa riverside villages in the Urals. Casts new light on the condition. Of value for all practitioners and researchers with an interest in chronic radiation syndrome. This book covers all aspects of chronic radiation syndrome (CRS) based on observations in a unique sample of residents of the Techa riverside villages in the southern Urals who were exposed to radioactive contamination in the 1950s owing to releases of liquid radioactive wastes from Mayak Production Association, which produced plutonium for weapons. In total, 940 cases of CRS were diagnosed in this population and these patients were subjected to detailed analysis. The opening chapters address the definition and classification of CRS, epidemiology and pathogenesis, covering molecular and cellular mechanisms, radioadaptation, and the role of tissue reactions. The pathoanatomy of CRS during the development and recovery stages is discussed for all organ systems. Clinical manifestations of CRS at the different stages are then described in detail and the dynamics of hematopoietic changes are thoroughly examined. In the following chapters, principles of diagnosis (including assessment of the exposure doses to critical organs) and differential diagnosis from a wide range of other conditions are discussed and current and potential treatment options, described. The medical and social rehabilitation of persons with CRS is also covered. This book, which casts new light on the condition, will be of value for all practitioners and researchers with an interest in CRS.

  8. The implications of re-analysing radiation-induced leukaemia in atomic bomb survivors: risks for acute and chronic exposures are different

    International Nuclear Information System (INIS)

    Implications of risk estimates, as required for practical radiation protection purposes, were explored through a preliminary re-analysis of leukaemia in the Japanese atomic bomb survivors using a biologically based cancer model. The calculations for the risks posed for contracting leukaemia pointed to important differences between low-dose-rate ('chronic') and high-dose-rate ('acute') exposures. For example, the risks caused by long-term ('chronic') exposures are calculated to be substantially lower than those for 'acute' exposures. In view of these model predictions the results of epidemiological studies are discussed. (author)

  9. Therapeutic and space radiation exposure of mouse brain causes impaired DNA repair response and premature senescence by chronic oxidant production

    OpenAIRE

    Suman, Shubhankar; Rodriguez, Olga C.; Winters, Thomas A.; Fornace, Albert J.; Albanese, Chris; Datta, Kamal

    2013-01-01

    Despite recent epidemiological evidences linking radiation exposure and a number of human ailments including cancer, mechanistic understanding of how radiation inflicts long-term changes in cerebral cortex, which regulates important neuronal functions, remains obscure. The current study dissects molecular events relevant to pathology in cerebral cortex of 6 to 8 weeks old female C57BL/6J mice two and twelve months after exposure to a γ radiation dose (2 Gy) commonly employed in fractionated r...

  10. Monitoring of radiation exposure

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-02-01

    The guide specifies the requirements for the monitoring of radiation exposure in instances where radiation is used. In addition to workers, the guide covers students, apprentices and visitors. The guide shall also apply to exposure from natural radiation. However, the monitoring of radiation exposure in nuclear power plants is dealt with in YVL Guide 7.10 and 7.11. The guide defines the concepts relevant to the monitoring of radiation exposure and provides guidelines for determining the necessity of monitoring and subsequently arranging such in different operations. In addition, the guide specifies the criteria for the approval and regulatory control of the dosimetric service.

  11. Monitoring of radiation exposure

    International Nuclear Information System (INIS)

    The guide specifies the requirements for the monitoring of radiation exposure in instances where radiation is used. In addition to workers, the guide covers students, apprentices and visitors. The guide shall also apply to exposure from natural radiation. However, the monitoring of radiation exposure in nuclear power plants is dealt with in YVL Guide 7.10 and 7.11. The guide defines the concepts relevant to the monitoring of radiation exposure and provides guidelines for determining the necessity of monitoring and subsequently arranging such in different operations. In addition, the guide specifies the criteria for the approval and regulatory control of the dosimetric service

  12. Hazards of radiation exposure

    International Nuclear Information System (INIS)

    Radiation induced carcinogenesis and mutagenesis form the main risks to health from exposure to low levels of radiation. There is scant data on somatic and genetic risks at environmental and occupational levels of radiation exposure. The available data on radiation induced carcinogenesis and mutagenesis are for high doses and high dose rates of radiation. Risk assessments for low level radiation are obtained using these data, assuming a linear dose-response relationship. During uranium mining the chief source of radiation hazard is inhalation of radon daughters. The correlation between radon daughter exposure and the increased incidence of lung cancer has been well documented. For radiation exposures at and below occupational limits, the associated risk of radiation induced cancers and genetic abnormalities is small and should not lead to a detectable increase over naturally occurring rates

  13. Radiation exposure records management

    International Nuclear Information System (INIS)

    Management of individual radiation exposure records begins at employment with the accumulation of data pertinent to the individual and any previous occupational radiation exposure. Appropriate radiation monitorinng badges or devices are issued and accountability established. A computer master file is initiated to include the individual's name, payroll number, social security number, birth date, assigned department, and location. From this base, a radiation exposure history is accumulated to include external ionizing radiation exposure to skin and whole body, contributing neutron exposure, contributing tritium exposure, and extremity exposure. It is used also to schedule bioassay sampling and in-vivo counts and to provide other pertinent information. The file is used as a basis for providing periodic reports to management and monthly exposure summaries to departmental line supervision to assist in planning work so that individual annual exposures are kept as low as practical. Radiation exposure records management also includes documentation of radiation surveys performed by the health physicist to establish working rates and the individual estimating and recording his estimated exposure on a day-to-day basis. Exposure information is also available to contribute to Energy Research and Development Administration statistics and to the National Transuranium Registry

  14. Pregnancy and Radiation Exposure

    Science.gov (United States)

    ... had that might impact the development of their sperm or their eggs (ova) and their risk of ... your concerns with them. Radiation Exposure to the Sperm from Diagnostic X-Ray Studies There are no ...

  15. Human circulating plasma DNA significantly decreases while lymphocyte DNA damage increases under chronic occupational exposure to low-dose gamma-neutron and tritium β-radiation

    Energy Technology Data Exchange (ETDEWEB)

    Korzeneva, Inna B., E-mail: inna.korzeneva@molgen.vniief.ru [Russian Federal Nuclear Center – All-Russian Research Institute of Experimental Physics (RFNC-VNIIEF) 607190, Sarov, 37 Mira ave., Nizhniy Novgorod Region (Russian Federation); Kostuyk, Svetlana V.; Ershova, Liza S. [Research Centre for Medical Genetics, Russian Academy of Medical Sciences, 115478 Moscow, 1 Moskvorechye str. (Russian Federation); Osipov, Andrian N. [Federal Medial and Biological Center named after Burnazyan of the Federal Medical and Biological Agency (FMBTz named after Burnazyan of FMBA), Moscow (Russian Federation); State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Zhivopisnaya, 46, Moscow, 123098 (Russian Federation); Zhuravleva, Veronika F.; Pankratova, Galina V. [Russian Federal Nuclear Center – All-Russian Research Institute of Experimental Physics (RFNC-VNIIEF) 607190, Sarov, 37 Mira ave., Nizhniy Novgorod Region (Russian Federation); Porokhovnik, Lev N.; Veiko, Natalia N. [Research Centre for Medical Genetics, Russian Academy of Medical Sciences, 115478 Moscow, 1 Moskvorechye str. (Russian Federation)

    2015-09-15

    Highlights: • The chronic exposure to low-dose IR induces DSBs in human lymphocytes (TM index). • Exposure to IR decreases the level of human circulating DNA (cfDNA index). • IR induces an increase of DNase1 activity (DNase1 index) in plasma. • IR induces an increase of the level of antibodies to DNA (Ab DNA index) in plasma. • The ratio cfDNA/(DNase 1 × Ab DNA × TM) is a potential marker of human exposure to IR. - Abstract: The blood plasma of healthy people contains cell-fee (circulating) DNA (cfDNA). Apoptotic cells are the main source of the cfDNA. The cfDNA concentration increases in case of the organism’s cell death rate increase, for example in case of exposure to high-dose ionizing radiation (IR). The objects of the present research are the blood plasma and blood lymphocytes of people, who contacted occupationally with the sources of external gamma/neutron radiation or internal β-radiation of tritium N = 176). As the controls (references), blood samples of people, who had never been occupationally subjected to the IR sources, were used (N = 109). With respect to the plasma samples of each donor there were defined: the cfDNA concentration (the cfDNA index), DNase1 activity (the DNase1 index) and titre of antibodies to DNA (the Ab DNA index). The general DNA damage in the cells was defined (using the Comet assay, the tail moment (TM) index). A chronic effect of the low-dose ionizing radiation on a human being is accompanied by the enhancement of the DNA damage in lymphocytes along with a considerable cfDNA content reduction, while the DNase1 content and concentration of antibodies to DNA (Ab DNA) increase. All the aforementioned changes were also observed in people, who had not worked with the IR sources for more than a year. The ratio cfDNA/(DNase1 × Ab DNA × TM) is proposed to be used as a marker of the chronic exposure of a person to the external low-dose IR. It was formulated the assumption that the joint analysis of the cfDNA, DNase1, Ab

  16. Human circulating plasma DNA significantly decreases while lymphocyte DNA damage increases under chronic occupational exposure to low-dose gamma-neutron and tritium β-radiation

    International Nuclear Information System (INIS)

    Highlights: • The chronic exposure to low-dose IR induces DSBs in human lymphocytes (TM index). • Exposure to IR decreases the level of human circulating DNA (cfDNA index). • IR induces an increase of DNase1 activity (DNase1 index) in plasma. • IR induces an increase of the level of antibodies to DNA (Ab DNA index) in plasma. • The ratio cfDNA/(DNase 1 × Ab DNA × TM) is a potential marker of human exposure to IR. - Abstract: The blood plasma of healthy people contains cell-fee (circulating) DNA (cfDNA). Apoptotic cells are the main source of the cfDNA. The cfDNA concentration increases in case of the organism’s cell death rate increase, for example in case of exposure to high-dose ionizing radiation (IR). The objects of the present research are the blood plasma and blood lymphocytes of people, who contacted occupationally with the sources of external gamma/neutron radiation or internal β-radiation of tritium N = 176). As the controls (references), blood samples of people, who had never been occupationally subjected to the IR sources, were used (N = 109). With respect to the plasma samples of each donor there were defined: the cfDNA concentration (the cfDNA index), DNase1 activity (the DNase1 index) and titre of antibodies to DNA (the Ab DNA index). The general DNA damage in the cells was defined (using the Comet assay, the tail moment (TM) index). A chronic effect of the low-dose ionizing radiation on a human being is accompanied by the enhancement of the DNA damage in lymphocytes along with a considerable cfDNA content reduction, while the DNase1 content and concentration of antibodies to DNA (Ab DNA) increase. All the aforementioned changes were also observed in people, who had not worked with the IR sources for more than a year. The ratio cfDNA/(DNase1 × Ab DNA × TM) is proposed to be used as a marker of the chronic exposure of a person to the external low-dose IR. It was formulated the assumption that the joint analysis of the cfDNA, DNase1, Ab

  17. Study of multi-generational effects of a chronic exposure to ionizing radiations at a model organism: the nematode Caenorhabditis elegans

    International Nuclear Information System (INIS)

    The environmental risk assessment of chronic exposure to ionizing radiation (natural and ubiquitous phenomenon enhanced by human activities) has become a major concern. Few studies relating to chronic exposure over several generations - essential knowledge to better understand the disruption caused by ionizing radiation and its possible consequences on the population - exist. In addition, it has become necessary to understand the mechanisms of disturbances related to ionizing radiation at the molecular and cellular level. Without this mechanistic understanding, it is difficult to extrapolate the effects observed between the different levels of biological organization and between different species. The aim of this PhD was to study the multi-generational effects of chronic gamma radiation in an integrated manner (to the life history traits from the subcellular mechanisms) in a model organism, the nematode Caenorhabditis elegans. A two-step strategy was implemented. First, studying the effects of chronic gamma radiation on the life history traits of C. elegans was performed. The objective of this experiment was to test the hypothesis of an increase of the sensitivity according generations. For that, three generations have been exposed to different dose rates. In parallel, two generations have been placed in 'control' environment after parental exposure to test a possible transmission of maternal effects. The second part of this thesis aimed to characterize the different subcellular mechanisms that could explain the observed effects on the life history traits after multi-generational exposure. The results showed that (i) the cumulative number of larvae was the most sensitive endpoint to gamma radiation, (ii) an increase in radiosensitivity was observed over three exposed generations and (iii) the effects of the parental generation were transmitted to the non-exposed generations. An increase in apoptosis, a reduction in the stock of sperm, and to a lesser

  18. Low chronic radiation doses

    International Nuclear Information System (INIS)

    In the context of the Chernobyl and Fukushima accidents where large territories have been contaminated durably and as consequence where local populations are submitted to chronic low radiation doses, IRSN (French institute for radiation protection and nuclear safety) has led various studies to assess the impact of chronic low doses. Studies about the effects of uranium on marine life show that the impact is strongly dependent on the initial state of the individual (zebra Danio rerio fish). The studies about the impact of chronic low doses due to cesium and strontium contamination show different bio-accumulations: 137Cs is found in the animal's whole body with higher concentrations in muscles and kidneys while 90Sr is found almost exclusively in bones and it accumulates more in female mice than in males. The study dedicated to the sanitary impact of chronic low doses on the workers of the nuclear industry shows a higher risk for developing a leukemia, a pleural cancer or a melanoma but no correlation appears between doses and the appearance of the pleural cancer or the melanoma. (A.C.)

  19. Radiation Risk from Chronic Low Dose-Rate Radiation Exposures: The Role of Life-Time Animal Studies - Workshop October 2005

    Energy Technology Data Exchange (ETDEWEB)

    Gayle Woloschak

    2009-12-16

    As a part of Radiation research conference, a workshop was held on life-long exposure studies conducted in the course of irradiation experiements done at Argonne National Laboratory between 1952-1992. A recent review article documents many of the issues discussed at that workshop.

  20. Occupational radiation exposure

    International Nuclear Information System (INIS)

    The X-ray and Radiation Protection Ordinances in the Federal Republic of Germany and Austria were discussed. The demands of protection ordinances can only be met if the monitoring of the radiation dose is ensured to a large extent. This was stated in the lectures on dosimetry, but also in those on the technical know-how and knowledge and the quality control in radiodiagnostics. The leukemia and cancer risk for persons exposed to radiation at work came also up for discussion, and the report on the re-evaluation of data about Hiroshima and Nagasaki showing a statistically recordable rise in cancer mortality has to be seen in connection with the radiation protection laws. A lecture was held on a radiation accident in Brazil in 1987 in order to give an example of an increased radiation exposure with a fatal result. It was an off-plant radiation accident. Since a physical dosimetry naturally cannot take place in such cases, it becomes necessary to inform oneself on the extent of the detriment by means of the detrimental characteristics of the irradiated organism. Also reported was the ''biological dosimetry'' of the radiation accident in Brazil. The 23 contributions have been separately recorded in the data base. (orig./DG) With 43 figs., 41 tabs

  1. Chronic TiO2 nanoparticle exposure to a benthic organism, Hyalella azteca: impact of solar UV radiation and material surface coatings on toxicity

    International Nuclear Information System (INIS)

    There is limited information on the chronic effects of nanomaterials to benthic organisms, as well as environmental mitigating factors that might influence this toxicity. The present study aimed to fill these data gaps by examining various growth endpoints (weight gain, instantaneous growth rate, and total protein content) for up to a 21 d sediment exposure of TiO2 nanoparticles (nano-TiO2) to a representative benthic species, Hyalella azteca. An uncoated standard, P25, and an Al(OH)3 coated nano-TiO2 used in commercial products were added to sediment at 20 mg/L or 100 mg/L Under test conditions, UV exposure alone was shown to be a greater cause of toxicity than even these high levels of nano-TiO2 exposure, indicating that different hazards need to be addressed in toxicity testing scenarios. In addition, this study showed the effectiveness of a surface coating on the decreased photoactivity of the material, as the addition of an Al(OH)3 coating showed a dramatic decrease in reactive oxygen species (ROS) production. However, this reduced photoactivity was found to be partially restored when the coating had been degraded, leading to the need for future toxicity tests which examine the implications of weathering events on particle surface coatings. - Highlights: • Chronic toxicity of nano-TiO2 to a benthic organism (Hyalella azteca) was examined. • Phototoxicity was investigated through exposure of solar simulated radiation (SSR). • The degradation of a surface coating resulted in an increase in photoactivity. • In this testing scenario, UV had a larger impact than chemical exposure in toxicity

  2. Chronic TiO{sub 2} nanoparticle exposure to a benthic organism, Hyalella azteca: impact of solar UV radiation and material surface coatings on toxicity

    Energy Technology Data Exchange (ETDEWEB)

    Wallis, Lindsay K. [Office of Research and Development, Mid-Continent Ecology Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Duluth, MN, 55804 (United States); Diamond, Stephen A. [Nanosafe Inc., Blacksburg, VA, 24060 (United States); Ma, Hongbo [University of Wisconsin-Milwaukee, Zilber School of Public Health, Milwaukee, WI, 53211 (United States); Hoff, Dale J. [Office of Research and Development, Mid-Continent Ecology Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Duluth, MN, 55804 (United States); Al-Abed, Souhail R. [National Risk Management Research Laboratory, U.S. Environmental Protection Agency, Cincinnati, OH 45268 (United States); Li, Shibin, E-mail: lishibinepa@gmail.com [Office of Research and Development, Mid-Continent Ecology Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Duluth, MN, 55804 (United States)

    2014-11-15

    There is limited information on the chronic effects of nanomaterials to benthic organisms, as well as environmental mitigating factors that might influence this toxicity. The present study aimed to fill these data gaps by examining various growth endpoints (weight gain, instantaneous growth rate, and total protein content) for up to a 21 d sediment exposure of TiO{sub 2} nanoparticles (nano-TiO{sub 2}) to a representative benthic species, Hyalella azteca. An uncoated standard, P25, and an Al(OH){sub 3} coated nano-TiO{sub 2} used in commercial products were added to sediment at 20 mg/L or 100 mg/L Under test conditions, UV exposure alone was shown to be a greater cause of toxicity than even these high levels of nano-TiO{sub 2} exposure, indicating that different hazards need to be addressed in toxicity testing scenarios. In addition, this study showed the effectiveness of a surface coating on the decreased photoactivity of the material, as the addition of an Al(OH){sub 3} coating showed a dramatic decrease in reactive oxygen species (ROS) production. However, this reduced photoactivity was found to be partially restored when the coating had been degraded, leading to the need for future toxicity tests which examine the implications of weathering events on particle surface coatings. - Highlights: • Chronic toxicity of nano-TiO{sub 2} to a benthic organism (Hyalella azteca) was examined. • Phototoxicity was investigated through exposure of solar simulated radiation (SSR). • The degradation of a surface coating resulted in an increase in photoactivity. • In this testing scenario, UV had a larger impact than chemical exposure in toxicity.

  3. Environmental radioactivity and radiation exposure

    International Nuclear Information System (INIS)

    In 1977 population exposure in the Federal Republic of Germany has not changed as compared to the previous years. The main share of the total exposure, nearly two thirds, is attributed to natural radioactive substances and cosmic radiation. The largest part (around 85%) of the artificial radiation exposure is caused by X-ray diagnostics. In comparison to this, radiation exposure from application of ionizing radiation in medical therapy, use of radioactive material in research and technology, or from nuclear facilities is small. As in the years before, population exposure caused by nuclear power plants and other nuclear facilities is distinctly less than 1% of the natural radiation exposure. This is also true for the average radiation exposure within a radius of 3 km around nuclear facilities. On the whole, the report makes clear that the total amount of artificial population exposure will substantially decrease only if one succeeds in reducing the high contribution to the radiation exposure caused by medical measures. (orig.)

  4. Human circulating plasma DNA significantly decreases while lymphocyte DNA damage increases under chronic occupational exposure to low-dose gamma-neutron and tritium β-radiation.

    Science.gov (United States)

    Korzeneva, Inna B; Kostuyk, Svetlana V; Ershova, Liza S; Osipov, Andrian N; Zhuravleva, Veronika F; Pankratova, Galina V; Porokhovnik, Lev N; Veiko, Natalia N

    2015-09-01

    The blood plasma of healthy people contains cell-fee (circulating) DNA (cfDNA). Apoptotic cells are the main source of the cfDNA. The cfDNA concentration increases in case of the organism's cell death rate increase, for example in case of exposure to high-dose ionizing radiation (IR). The objects of the present research are the blood plasma and blood lymphocytes of people, who contacted occupationally with the sources of external gamma/neutron radiation or internal β-radiation of tritium N = 176). As the controls (references), blood samples of people, who had never been occupationally subjected to the IR sources, were used (N = 109). With respect to the plasma samples of each donor there were defined: the cfDNA concentration (the cfDNA index), DNase1 activity (the DNase1 index) and titre of antibodies to DNA (the Ab DNA index). The general DNA damage in the cells was defined (using the Comet assay, the tail moment (TM) index). A chronic effect of the low-dose ionizing radiation on a human being is accompanied by the enhancement of the DNA damage in lymphocytes along with a considerable cfDNA content reduction, while the DNase1 content and concentration of antibodies to DNA (Ab DNA) increase. All the aforementioned changes were also observed in people, who had not worked with the IR sources for more than a year. The ratio cfDNA/(DNase1×Ab DNA × TM) is proposed to be used as a marker of the chronic exposure of a person to the external low-dose IR. It was formulated the assumption that the joint analysis of the cfDNA, DNase1, Ab DNA and TM values may provide the information about the human organism's cell resistivity to chronic exposure to the low-dose IR and about the development of the adaptive response in the organism that is aimed, firstly, at the effective cfDNA elimination from the blood circulation, and, secondly - at survival of the cells, including the cells with the damaged DNA. PMID:26113293

  5. Doses from radiation exposure

    CERN Document Server

    Menzel, H G

    2012-01-01

    Practical implementation of the International Commission on Radiological Protection's (ICRP) system of protection requires the availability of appropriate methods and data. The work of Committee 2 is concerned with the development of reference data and methods for the assessment of internal and external radiation exposure of workers and members of the public. This involves the development of reference biokinetic and dosimetric models, reference anatomical models of the human body, and reference anatomical and physiological data. Following ICRP's 2007 Recommendations, Committee 2 has focused on the provision of new reference dose coefficients for external and internal exposure. As well as specifying changes to the radiation and tissue weighting factors used in the calculation of protection quantities, the 2007 Recommendations introduced the use of reference anatomical phantoms based on medical imaging data, requiring explicit sex averaging of male and female organ-equivalent doses in the calculation of effecti...

  6. Enzyme diagnostics following radiation exposure. Usefulness and limits

    International Nuclear Information System (INIS)

    Based on the results of animal studies and a literature survey, recommendations are given for the application of enzyme diagnostics in the following fields of radiation protection medicine: (1) pre-employment medical examinations and health supervision of radiation workers, (2) medical examinations following chronic radiation exposure, and (3) medical examinations following acute radiation exposure. (author)

  7. Effect of chronic exposure to gamma radiation and of hormonal stimulation with serum gonadotropin on catecholamine levels in hypothalamus, epiphysis and adrenals of ewes

    International Nuclear Information System (INIS)

    The effects were studied of exposure to whole body continuous irradiation and of the administration of serum gonadotropin (SG) on the concentration of catecholamines (epinephrine and norepinephrine) in the hypothalamus, epiphysis and adrenal glands of ewes during the anestric period with synchronized estrus. The first group (young barren ewes) and second group (older ewes) were exposed to continuous radiation of 60Co for five days. The radiation was applied at a rate of 0.020 Gy per hour. After the termination of irradiation the ewes were subjected to hormonal stimulation by fractionated administration of 1500 I.U. SG. The third and fourth experimental groups of ewes were stimulated with 1500 I.U. SG without irradiation. Catecholamines were separated from the tissue supernatants by adsorption chromatography and the catecholamine contents in the eluates were determined spectrofluorometrically. Chronic exposure to gamma radiation and hormonal stimulation with SG reduced the concentration of norepinephrine in the whole hypothalamus of the sheep. A statistically significant decrease (P<0.001) was recorded in the medial and caudal hypothalamus of the adult ewes and in the rostral and caudal hypothalamus regions of the young ewes. A decrease in norepinephrine concentration, statistically significant in the caudal (P<0.01) and medial hypothalamus was recorded in the group of adult ewes after hormonal stimulation with SG without irradiation. The experimental group of young ewes responded to hormonal stimulation by a greater reduction of norepinephrine contents as compared with combined exposure to radiation and hormonal stimulation. It is assumed that the decrease in catecholamine concentration after hormonal stimulation with SG is associated with the increase in the contents of estrogens which act on the adrenergic receptors of the hypothalamus. (author). 4 figs., 21 refs

  8. Epidemiology of accidental radiation exposures.

    OpenAIRE

    Cardis, E

    1996-01-01

    Much of the information on the health effects of radiation exposure available to date comes from long-term studies of the atomic bombings in Hiroshima and Nagasaki. Accidental exposures, such as those resulting from the Chernobyl and Kyshtym accidents, have as yet provided little information concerning health effects of ionizing radiation. This paper will present the current state of our knowledge concerning radiation effects, review major large-scale accidental radiation exposures, and discu...

  9. Estimation of health effects of long-term chronic exposure of the low level radiation among children exposed in consequence of the disaster at the Chernobyl nuclear power plant

    International Nuclear Information System (INIS)

    The low level dose effects have been studied for a long time within a framework of biological effects of radiation exposure. The estimation of the dose level of Ukrainian people who have been exposed in consequence of the Chernobyl accident allowed to consider that one of the critical populations which had been exposed to the low level radiation were children residing on the areas contaminated with radionuclides. The purpose of this work is - to reveal a regularity in morbidity and mortality of the critical populations having been exposed to long-term chronic exposure of the low level doses of radiation in consequences of the Chernobyl accident

  10. Pregnancy and radiation exposure

    International Nuclear Information System (INIS)

    In confirmed or presumptive pregnancy it is especially critical to determine the indications for X-ray examination. This assumes that every young woman, before an examination in the pelvic region, be asked explicity when her last normal period was. Examinations of the pelvis which are not acutely necessary should be postponed until the first 10 days after menstruation. If radiologic examination of the true pelvis must be carried out despite pregnancy or is inadvertently done because pregnancy was not recognized, the radiation exposure of the embryo is so small in most cases because of modern dose-sparing equipment, that an interruption of pregnancy is not justified. A dose of less than 1 rad is, as a rule, justifiable, but it is less justifiable that alarmed, uninformed physicians instill a deep-seated fear of giving brith to a freak in a woman through false information. (orig.)

  11. Health consequences of ionizing radiation exposure

    International Nuclear Information System (INIS)

    Full text: The increasing use of ionizing radiations all over the world induces an ever increasing interest of the professionals as well as of the whole society in health protection and the risk due to these practices. Shortly after its discovery, it was recognized that ionizing radiation can have adverse health effects and knowledge of its detrimental effects has accumulated. The fact that ionizing radiation produces biological damage has been known for many years. The biological effects of ionizing radiation for radiation protection considerations are grouped into two categories: The deterministic and the stochastic ones. Deterministic radiation effects can be clinically diagnosed in the exposed individual and occur when above a certain 'threshold' an appropriately high dose is absorbed in the tissues and organs to cause the death of a large number of cells and consequently to impair tissue or organ functions early after exposure. A clinically observable biological effect (Acute Radiation Syndromes, ARS) that occurs days to months after an acute radiation dose. ARS is a complex of acute injury manifestations that occur after a sufficiently large portion of a person's body is exposed to a high dose of ionizing radiation. Such irradiation initially injures all organs to some extent, but the timing and extent of the injury manifestations depend upon the type, rate, and dose of radiation received. Stochastic radiation effects are the chronic effects of radiation result from relatively low exposure levels delivered over long periods of time. These are sort of effects that might result from occupational exposure, or to the background exposure levels (includes radioactive pollution). Such late effects might be the development of malignant (cancerous) disease and of the hereditary consequences. These effects may be observed many years after the radiation exposure. There is a latent period between the initial radiation exposure and the development of the biological effect

  12. Health consequences of ionizing radiation exposure

    International Nuclear Information System (INIS)

    The increasing use of ionizing radiations all over the world induces an ever increasing interest of the professionals as well as of the whole society in health protection and the risk due to these practices. Shortly after its discovery, it was recognized that ionizing radiation can have adverse health effects and knowledge of its detrimental effects has accumulated. The fact that ionizing radiation produces biological damage has been known for many years. The biological effects of ionizing radiation for radiation protection considerations are grouped into two categories: The deterministic and the stochastic ones. Deterministic radiation effects can be clinically diagnosed in the exposed individual and occur when above a certain 'threshold' an appropriately high dose is absorbed in the tissues and organs to cause the death of a large number of cells and consequently to impair tissue or organ functions early after exposure. A clinically observable biological effect (Acute Radiation Syndromes, ARS) that occurs days to months after an acute radiation dose. ARS is a complex of acute injury manifestations that occur after a sufficiently large portion of a person's body is exposed to a high dose of ionizing radiation. Such irradiation initially injures all organs to some extent, but the timing and extent of the injury manifestations depend upon the type, rate, and dose of radiation received. Stochastic radiation effects are the chronic effects of radiation result from relatively low exposure levels delivered over long periods of time. These are sort of effects that might result from occupational exposure, or to the background exposure levels (includes radioactive pollution). Such late effects might be the development of malignant (cancerous) disease and of the hereditary consequences. These effects may be observed many years after the radiation exposure. There is a latent period between the initial radiation exposure and the development of the biological effect. In this

  13. DOE 2012 occupational radiation exposure

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2013-10-01

    The U.S. Department of Energy (DOE) Office of Analysis within the Office of Health, Safety and Security (HSS) publishes the annual DOE Occupational Radiation Exposure Report to provide an overview of the status of radiation protection practices at DOE (including the National Nuclear Security Administration [NNSA]). The DOE 2012 Occupational Radiation Exposure Report provides an evaluation of DOE-wide performance regarding compliance with Title 10, Code of Federal Regulations (C.F.R.), Part 835, Occupational Radiation Protection dose limits and as low as reasonably achievable (ALARA) process requirements. In addition, the report provides data to DOE organizations responsible for developing policies for protection of individuals from the adverse health effects of radiation. The report provides a summary and an analysis of occupational radiation exposure information from the monitoring of individuals involved in DOE activities. Over the past 5-year period, the occupational radiation exposure information is analyzed in terms of aggregate data, dose to individuals, and dose by site.

  14. DOE 2011 occupational radiation exposure

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2012-12-01

    The U.S. Department of Energy (DOE) Office of Analysis within the Office of Health, Safety and Security (HSS) publishes the annual DOE Occupational Radiation Exposure Report to provide an overview of the status of radiation protection practices at DOE (including the National Nuclear Security Administration [NNSA]). The DOE 2011 Occupational Radiation Exposure Report provides an evaluation of DOE-wide performance regarding compliance with Title 10, Code of Federal Regulations (C.F.R.), Part 835, Occupational Radiation Protection dose limits and as low as reasonably achievable (ALARA) process requirements. In addition, the report provides data to DOE organizations responsible for developing policies for protection of individuals from the adverse health effects of radiation. The report provides a summary and an analysis of occupational radiation exposure information from the monitoring of individuals involved in DOE activities. The occupational radiation exposure information is analyzed in terms of aggregate data, dose to individuals, and dose by site over the past five years.

  15. Environmental radiation and exposure to radiation

    International Nuclear Information System (INIS)

    Compared to 1977 the exposure to radiation of the population of the Federal Republic of Germany from both natural and artificial radiation sources has not greatly charged. The amin part of exposure to natural radiation is caused by environmental radiation and by the absorption of naturally radioactive substances into the body. Artificial exposure to radiation of the population is essentially caused by the use of ionizing rays and radioactive substances in medicine. When radioactive materials are released from nuclear facilities the exposure to radiation of the population is only very slightly increased. The real exposure to radiation of individual people can even in the worst affected places, have been at most fractions of a millirem. The exposure to radiation in the worst afected places in the area of a hard-coal power station is higher than that coming from a nuclear power station of the same capacity. The summation of all contributions to the exposure of radiation by nuclear facilities to the population led in 1978 in the Federal Republic of Germany to a genetically significant dose of clearly less than 1 millerem per year. The medium-ranged exposure to radiation by external radiation effects through professional work was in 1978 at 80 millirems. No difference to 1977. The contribution of radionuclide from the fallout coming from nuclear-weapon tests and which has been deposited in the soil, to the whole-body dose for 1978 applies the same as the genetically significant dose of the population with less than 1 millirem. (orig./HP)

  16. DOE 2010 occupational radiation exposure

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2011-11-01

    The U.S. Department of Energy (DOE) Office of Analysis within the Office of Health, Safety and Security (HSS) publishes the annual DOE Occupational Radiation Exposure Report to provide an overview of the status of radiation protection practices at DOE.* The DOE 2010 Occupational Radiation Exposure Report provides an evaluation of DOE-wide performance regarding compliance with DOE Part 835 dose limits and as low as reasonably achievable (ALARA) process requirements. In addition, the report provides data to DOE organizations responsible for developing policies for protection of individuals from the effects of radiation. The report provides a summary and an analysis of occupational radiation exposure information from the monitoring of individuals involved in DOE activities. The occupational radiation exposure information is analyzed in terms of aggregate data, dose to individuals, and dose by site over the past 5 years.

  17. DOE 2009 occupational radiation exposure

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2010-09-01

    The U.S. Department of Energy (DOE) Office of Corporate Safety Analysis (HS-30) within the Office of Health, Safety and Security (HSS) publishes the annual DOE Occupational Radiation Exposure Report to provide an overview of the status of radiation protection practices at DOE.* The DOE 2009 Occupational Radiation Exposure Report provides an evaluation of DOE-wide performance regarding compliance with DOE Part 835 dose limits and as low as reasonably achievable (ALARA) process requirements. In addition, the report provides data to DOE organizations responsible for developing policies for protection of individuals from the effects of radiation. The report provides a summary and an analysis of occupational radiation exposure information from the monitoring of individuals involved in DOE activities. The occupational radiation exposure information is analyzed in terms of aggregate data, dose to individuals, and dose by site over the past 5 years.

  18. DOE 2008 occupational radiation exposure

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2009-10-01

    The U.S. Department of Energy (DOE) Office of Corporate Safety Analysis (HS-30) within the Office of Health, Safety and Security (HSS) publishes the annual DOE Occupational Radiation Exposure Report to provide an overview of the status of radiation protection practices at DOE. The DOE 2008 Occupational Radiation Exposure Report provides an evaluation of DOE-wide performance regarding compliance with DOE Part 835 dose limits and as low as reasonably achievable (ALARA) process requirements. In addition, the report provides data to DOE organizations responsible for developing policies for protection of individuals from the effects of radiation. This report provides a summary and an analysis of occupational radiation exposure information from the monitoring of individuals involved in DOE activities. The occupational radiation exposure information is analyzed in terms of aggregate data, dose to individuals, and dose by site over the past 5 years.

  19. Occupational exposure to ionizing radiation

    International Nuclear Information System (INIS)

    An overview of occupational exposure is presented. Concepts and quantities used for radiation protection are explained as well as the ICRP system of dose limitation. The risks correlated to the limits are discussed. However, the actual exposure are often much lower than the limits and the average risk in radiation work is comparable with the average risk in other safe occupations. Actual exposures in various occupations are presented and discussed. (author)

  20. Chronic effects of ionizing radiation on animals and humans

    International Nuclear Information System (INIS)

    Numerous experimental radiobiological studies and medical observations were conducted after the Chernobyl disaster based on the published results; patterns and characteristics influence of the fission products of nuclear materials on the body of mammals, including humans were analyzed. Chronic exposure to low doses leads to the changes in the hemopoietic system was founded and increases the risk of myeloproliferative diseases. The consequence of radiation-related immunodeficiency is the autoimmune disease and chronic fatigue syndrome. Radiation damage leads to endocrine system disruption of the body and of polipatologycal states. High radiosensitivity of the central nervous system was founded. Genotoxic chronic radiation exposure threatens the stability of the genome

  1. Radiation exposures: risks and realities

    International Nuclear Information System (INIS)

    Discovery of radioactivity in 1869 by Henry Becquerel and artificial radioactivity by Irene Curie in 1934 led to the development of nuclear field and nuclear materials in 20th century. They are widely used for man-kind across the globe in electricity production, carbon dating, treatment and diagnosis of diseases etc. While deriving benefits and utilizing nuclear resources for the benefit of man-kind, it is inevitable that exposure to radiation can not be avoided. Radiation exists all around us either natural or man-made which can not be totally eliminated or avoided. Radiation exposures from natural background contribute 2.4 to 3.6 mSv in a year. Radiation exposures incurred by a member of public due to nuclear industries constitute less than one hundredth of annual dose due to natural background. Hence it is important to understand the risk posed by radiation and comparison of radiation risk with various risks arising due to other sources. Studies have indicated that risks due to environmental pollution, cigarette smoking, alcohol consumption, heart diseases are far higher in magnitude compared to radiation risks from man made sources. This paper brings about the details and awareness regarding radiation exposures, radiation risk, various risks associated with other industries and benefits of radiation exposures. (author)

  2. Radiation exposure from building materials

    International Nuclear Information System (INIS)

    A survey procedure was developed to find buildings in which the radiation exposure from gamma rays is relatively high. For modern structures NaI(Tl) survey meters are used to identify building materials with higher radionuclide content. Samples of these materials are analyzed by gamma-ray spectroscopy for 226Ra daughters, 232Th daughters, and 40K. The exposure rate in a building is computed from these concentrations on the basis of the geometrical configuration of building materials, acting both as radiation sources and as a shield against terrestrial radiation, and also on the basis of the outside radiation exposure rate at the building site. The procedure may also be applied to surveys of building material constituents and to materials in place in older structures. A calculational model was developed to predict radiation exposure rates within the houses

  3. Occupational Exposures and Chronic Airflow Limitation

    Directory of Open Access Journals (Sweden)

    Helen Dimich-Ward

    1996-01-01

    Full Text Available The recent literature was reviewed to evaluate whether chronic airflow limitation is associated with occupational exposures to dusts. Only those studies that controlled for the effects of smoking were included. There is compelling evidence that exposure to inorganic dusts, such as from coal and hardrock mining or asbestos, are associated with the development of chronic airflow limitation, independently of pneumoconiosis. Nonsmoking gold miners are particularly at high risk of airflow obstruction and emphysema. Findings from studies of organic dusts, such as exposures to wood, cotton, grain or other agricultural dusts, or to mixed dust exposures, were less consistent but tended to show positive dose-response associations. In the majority of studies, no statistical interaction was shown between dust exposures and smoking; however, the effects of the dust exposures were often more pronounced. An occupational history should be considered, in addition to a smoking history, as an integral part of an investigation of chronic airflow limitation in a patient.

  4. Morphological peculiarities of chronic gastritis in children and adolescents of Belarus under conditions of low dose radiation-chemical exposure

    International Nuclear Information System (INIS)

    Following the accident at the Chernobyl nuclear power station, the unfavourable ecological situation due to chemical contamination of the environment was aggravated by the radiation effect. At present, radionuclides of caesium and lead, as well as the nitrates, are the most widely distributed ecotoxicants. Under conditions of the negative ecological effect as the result of per os penetration of the majority of xenobiotics, the gastro-intestinal tract is at particular risk. During 1990-1994, 442 children and adolescents aged 10-17 residing at the ecologically different regions of the Republic have been examined. The program of examination included morphological investigation of bioptates of the stomach mucous membrane, determination of the radiocaesium specific activity in the body and the evaluation of lead content in blood and nitrates content in urine. (author)

  5. Radiation exposure and infant cancer

    International Nuclear Information System (INIS)

    Medical exposures accompanied by an increase in radiation use in the field of pediatrics were described. Basic ideas and countermeasures to radiation injuries were outlined. In order to decrease the medical exposure, it is necessary for the doctor, x-ray technician and manufacturer to work together. The mechanism and characteristics of radio carcinogenesis were also mentioned. Particularly, the following two points were described: 1) How many years does it take before carcinogenesis appears as a result of radiation exposure in infancy 2) How and when does the effect of fetus exposure appear. Radiosensitivity in infants and fetuses is greater than that of an adult. The occurrence of leukemia caused by prenatal exposure was reviewed. The relation between irradiation for therapy and morbidity of thyroid cancer was mentioned. Finally, precautions necessary for infants, pregnant women and nursing mothers when using radioisotopes were mentioned. (K. Serizawa)

  6. Carcinogenesis by internal radiation exposures

    International Nuclear Information System (INIS)

    Radiation carcinogenesis is based on the same molecular mechanisms, while spatial and temporal dose distribution in target cells is differed between internal and external radiation exposures. Animal models on dose-carcinogenic response relationships are required to complement an uncertainties in human epidemiological studies and finally to estimate human risk of internal exposures to radionuclides. Several dose response models for experimental carcinogenesis by internally administered radionuclides in laboratory animals were reviewed and discussed in this paper. (J.P.N.)

  7. Radiation Exposure and Pregnancy

    Science.gov (United States)

    ... radiation and was devel- oped by the Health Physics Society. Stabin M, Breitz H. Breast milk excretion of radiopharmaceuticals: Mechanisms, findings, and radiation dosimetry. Continuing Medical Education Article, Journal of Nuclear Medicine 41(5):863-873; 2000. U.S. Nuclear ...

  8. Radiation Exposure and Cancer

    Science.gov (United States)

    ... Compensation Programs for People Exposed to Radiation as Part of Nuclear Weapons Testing Between 1945 and 1962, several countries tested nuclear weapons in the open air. The US government has passed several laws to ... radiation as part of nuclear testing programs who later develop certain ...

  9. Malignant mesothelioma following radiation exposure

    Energy Technology Data Exchange (ETDEWEB)

    Antman, K.H.; Corson, J.M.; Li, F.P.; Greenberger, J.; Sytkowski, A.; Henson, D.E.; Weinstein, L.

    1983-11-01

    Mesothelioma developed in proximity to the field of therapeutic radiation administered 10-31 years previously in four patients. In three, mesothelioma arose within the site of prior therapeutic radiation for another cancer. Mesothelioma in the fourth patient developed adjacent to the site of cosmetic radiation to a thyroidectomy scar. None of these four patients recalled an asbestos exposure or had evidence of asbestosis on chest roentgenogram. Lung tissue in one patient was negative for ferruginous bodies, a finding considered to indicate no significant asbestos exposure. Five other patients with radiation-associated mesothelioma have been reported previously, suggesting that radiation is an uncommon cause of human mesothelioma. Problems in the diagnosis of radiation-associated mesotheliomas are considered.

  10. Malignant mesothelioma following radiation exposure

    International Nuclear Information System (INIS)

    Mesothelioma developed in proximity to the field of therapeutic radiation administered 10-31 years previously in four patients. In three, mesothelioma arose within the site of prior therapeutic radiation for another cancer. Mesothelioma in the fourth patient developed adjacent to the site of cosmetic radiation to a thyroidectomy scar. None of these four patients recalled an asbestos exposure or had evidence of asbestosis on chest roentgenogram. Lung tissue in one patient was negative for ferruginous bodies, a finding considered to indicate no significant asbestos exposure. Five other patients with radiation-associated mesothelioma have been reported previously, suggesting that radiation is an uncommon cause of human mesothelioma. Problems in the diagnosis of radiation-associated mesotheliomas are considered

  11. Designing to minimize radiation exposure

    International Nuclear Information System (INIS)

    The radiation exposure received by the station staff must be considered during the design stage if CANDU stations are to achieve high capacity factor, high reliability and low maintenance and operational costs. On early CANDU stations, this exposure was higher than originally anticipated. Reviews to reduce exposure were started in 1969 and these have evolved into a formal program which defines specific objectives, classifies radiation levels, reviews designs and implements improvements where necessary. This paper outlines the program developed at AECL-PP (Power Projects) for use during the design of CANDU stations. (author)

  12. Sarcoma risk after radiation exposure

    Directory of Open Access Journals (Sweden)

    Berrington de Gonzalez Amy

    2012-10-01

    Full Text Available Abstract Sarcomas were one of the first solid cancers to be linked to ionizing radiation exposure. We reviewed the current evidence on this relationship, focusing particularly on the studies that had individual estimates of radiation doses. There is clear evidence of an increased risk of both bone and soft tissue sarcomas after high-dose fractionated radiation exposure (10 + Gy in childhood, and the risk increases approximately linearly in dose, at least up to 40 Gy. There are few studies available of sarcoma after radiotherapy in adulthood for cancer, but data from cancer registries and studies of treatment for benign conditions confirm that the risk of sarcoma is also increased in this age-group after fractionated high-dose exposure. New findings from the long-term follow-up of the Japanese atomic bomb survivors suggest, for the first time, that sarcomas can be induced by acute lower-doses of radiation (

  13. DOE 2013 occupational radiation exposure

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2014-11-01

    The Office of Analysis within the U.S. Department of Energy (DOE) Office of Environment, Health, Safety and Security (EHSS) publishes the annual DOE Occupational Radiation Exposure Report to provide an overview of the status of radiation protection practices at DOE (including the National Nuclear Security Administration [NNSA]). The DOE 2013 Occupational Radiation Exposure Report provides an evaluation of DOE-wide performance regarding compliance with Title 10, Code of Federal Regulations (C.F.R.), Part 835, Occupational Radiation Protection dose limits and as low as reasonably achievable (ALARA) process requirements. In addition, the report provides data to DOE organizations responsible for developing policies for protection of individuals from the adverse health effects of radiation. The report provides a summary and an analysis of occupational radiation exposure information from the monitoring of individuals involved in DOE activities. Over the past five-year period, the occupational radiation exposure information has been analyzed in terms of aggregate data, dose to individuals, and dose by site.

  14. Cardiovascular complications of radiation exposure.

    Science.gov (United States)

    Finch, William; Shamsa, Kamran; Lee, Michael S

    2014-01-01

    The cardiovascular sequelae of radiation exposure are an important cause of morbidity and mortality following radiation therapy for cancer, as well as after exposure to radiation after atomic bombs or nuclear accidents. In the United States, most of the data on radiation-induced heart disease (RIHD) come from patients treated with radiation therapy for Hodgkin disease and breast cancer. Additionally, people exposed to radiation from the atomic bombs in Hiroshima and Nagasaki, Japan, and the Chernobyl, Ukraine, nuclear accident have an increased risk of cardiovascular disease. The total dose of radiation, as well as the fractionation of the dose, plays an important role in the development of RIHD. All parts of the heart are affected, including the pericardium, vasculature, myocardium, valves, and conduction system. The mechanism of injury is complex, but one major mechanism is injury to endothelium in both the microvasculature and coronary arteries. This likely also contributes to damage and fibrosis within the myocardium. Additionally, various inflammatory and profibrotic cytokines contribute to injury. Diagnosis and treatment are not significantly different from those for conventional cardiovascular disease; however, screening for heart disease and lifelong cardiology follow-up is essential in patients with past radiation exposure. PMID:25290729

  15. Assessing exposure to radiation

    International Nuclear Information System (INIS)

    Since the founding of Lawrence Livermore National Laboratory, we have been world leaders in evaluating the risks associated with radiation. Ultrasensitive tools allow us not only to measure radionuclides present in the body but also to reconstruct the radiation dose from past nuclear events and to project the levels of radiation that will still be present in the body for 50 years after the initial intake. A variety of laboratory procedures, including some developed here, give us detailed information on the effects of radiation at the cellular level. Even today, we are re-evaluating the neutron dose resulting from the bombing at Hiroshima. Our dose reconstruction and projection capabilities have also been applied to studies of Nagasaki, Chernobyl, the Mayak industrial complex in the former Soviet Union, the Nevada Test Site, Bikini Atoll, and other sites. We are evaluating the information being collected on individuals currently working with radioactive material at Livermore and elsewhere as well as previously collected data on workers that extends back to the Manhattan Project

  16. Environmental radioactivity and radiation exposure

    International Nuclear Information System (INIS)

    The environmental radioactivity in the Federal Republic of Germany was almost as high in 1976 as in 1975. It only increased temporarily in autumn 1976 as a result of the above-ground nuclear weapons test of the People's Republic of China on September 29th 1976 and then returned to its previous level. The radioactivity in food had a slight decreasing trend in 1976, apart from a temporary increase in the radioactivity in milk also caused by the nuclear weapons test mentioned. The population exposure remains basically unchanged in 1976 compared with 1975. The artificial radiation exposure is about half as high as the natural radiation exposure to which man has always been exposed. The former is based to 83% on using X-rays in medicine, particularly for X-ray diagnostic purposes. The population exposure due to nuclear power plants and other nuclear plants is still well below 1% of the natural radiation exposure although in 1976 three new nuclear power plants were put into operation. This is also true for the average radiation exposure within an area of 3 km around the nuclear plant. (orig.)

  17. Radiation Exposure of Passengers to Cosmic Radiation

    International Nuclear Information System (INIS)

    The main aim of the present study is to review exposure of Egyptian passengers and occupational workers to cosmic radiation during their work. Computed effective dose of passengers by computer code CARI-6 using during either short route, medium route or long route as well as recommended allowed number of flights per year

  18. Human exposure to ultraviolet radiation.

    Science.gov (United States)

    Diffey, B L

    1990-03-01

    Although the sun remains the main source of ultraviolet radiation (UVR) exposure in humans, the advent of artificial UVR sources has increased the opportunity for both intentional and unintentional exposure. Intentional exposure is most often to tan the skin. People living in less sunny climates can now maintain a year-round tan by using sunbeds and solaria emitting principally UVA radiation. Another reason for intentional exposure to artificial UVR is treatment of skin diseases, notably psoriasis. Unintentional exposure is normally the result of occupation. Outdoor workers, such as farmers, receive three to four times the annual solar UV exposure of indoor workers. Workers in many industries, eg, photoprinting or hospital phototherapy departments, may be exposed to UVR from artificial sources. One group particularly at risk is electric arc welders, where inadvertent exposure is so common that the terms "arc eye" or "welders flash" are often used to describe photokeratitis. In addition to unavoidable exposure to natural UVR, the general public is exposed to low levels of UVR from sources such as fluorescent lamps used for indoor lighting and shops and restaurants where UVA lamps are often used in traps to attract flying insects. PMID:2203439

  19. Psychiatric disorders after radiation exposure

    International Nuclear Information System (INIS)

    This review focuses on the mental and psychological effects of medical radiation exposure, the nuclear accident at Three Mile Island, the Chernobyl disaster, atomic bomb explosions at Nagasaki and Hiroshima, and accidents at nuclear power plants and nuclear waste plants. Studies have shown that anxiety about the adverse effects of radiation in medicine (such as infertility, carcinogenicity, and genotoxicity) and fear for exposure has caused psychiatric disorders. Several studies on the mental health effects of the nuclear accident at Three Mile Island were conducted, and the results indicated that psychiatric distress persisted for a certain period of time, particularly in pregnant women and women who have children, even when no evidence of substantial of radiation exposure is seen clinically. The psychological consequences of the Chernobyl disaster have been investigated continuously, and various problems, e.g., acute stress reaction, neurosis, and psychosis, have been identified, although no physical damage due to the radiation or PTSD have been reported. By contrast, PTSD has been seen in survivors of the Nagasaki and Hiroshima nuclear explosions. A study in Ohio, (United States), which has a nuclear waste plant, investigated PTSD in people living near the plant and found that the symptom level was mild. In general, the most common symptoms among people with mental and psychological disorders due to radiation exposure are depression and anxiety, with many people having associated somatoform disorders, and some people complain of PTSD. Vague anxiety and fear of sequelae, regardless of the exposure dose, appears to cause such psychiatric disorders. Although it is rare for psychiatrists to see such cases of psychiatric disorders due to radiation exposure, their number may increase as psychiatric services become more widely available. (K.H.)

  20. Psychiatric disorders after radiation exposure

    Energy Technology Data Exchange (ETDEWEB)

    Kokai, Masahiro [Hyogo Coll. of Medicine, Nishinomiya (Japan); Soejima, Toshinori; Wang, Shangdong; Shinfuku, Naotaka

    2001-04-01

    This review focuses on the mental and psychological effects of medical radiation exposure, the nuclear accident at Three Mile Island, the Chernobyl disaster, atomic bomb explosions at Nagasaki and Hiroshima, and accidents at nuclear power plants and nuclear waste plants. Studies have shown that anxiety about the adverse effects of radiation in medicine (such as infertility, carcinogenicity, and genotoxicity) and fear for exposure has caused psychiatric disorders. Several studies on the mental health effects of the nuclear accident at Three Mile Island were conducted, and the results indicated that psychiatric distress persisted for a certain period of time, particularly in pregnant women and women who have children, even when no evidence of substantial of radiation exposure is seen clinically. The psychological consequences of the Chernobyl disaster have been investigated continuously, and various problems, e.g., acute stress reaction, neurosis, and psychosis, have been identified, although no physical damage due to the radiation or PTSD have been reported. By contrast, PTSD has been seen in survivors of the Nagasaki and Hiroshima nuclear explosions. A study in Ohio, (United States), which has a nuclear waste plant, investigated PTSD in people living near the plant and found that the symptom level was mild. In general, the most common symptoms among people with mental and psychological disorders due to radiation exposure are depression and anxiety, with many people having associated somatoform disorders, and some people complain of PTSD. Vague anxiety and fear of sequelae, regardless of the exposure dose, appears to cause such psychiatric disorders. Although it is rare for psychiatrists to see such cases of psychiatric disorders due to radiation exposure, their number may increase as psychiatric services become more widely available. (K.H.)

  1. Radiation exposure in manned spaceflight

    International Nuclear Information System (INIS)

    Space missions exposure humans to a radiation environment of a particulate composition and intensity not encountered within our biosphere. The natural radiation environment encountered in Earth orbit is a complex mixture of charged particles of galactic and solar origin and of those trapped by the geomagnetic field. In addition, secondaries are produced by interaction of cosmic ray primaries with the spacecraft shielding material. Among this large variety of radiation components in space, it is likely that the heavy ions are the significant species as far as radiobiological effects are concerned. In addition, a synergistic interaction of microgravity and radiation on living systems has been reported in some instances. Based on an admissible risk of 3% mortality due to cancers induced during a working career, radiation protection guidelines have been developed for this radiation environment. (orig.)

  2. Hematologic consequences of exposure to ionizing radiation.

    Science.gov (United States)

    Dainiak, Nicholas

    2002-06-01

    From the early 1900s, it has been known that ionizing radiation (IR) impairs hematopoiesis through a variety of mechanisms. IR exposure directly damages hematopoietic stem cells and alters the capacity of bone marrow stromal elements to support and/or maintain hematopoiesis in vivo and in vitro. Exposure to IR induces dose-dependent declines in circulating hematopoietic cells not only through reduced bone marrow production, but also by redistribution and apoptosis of mature formed elements of the blood. Recently, the importance of using lymphocyte depletion kinetics to provide a "crude" dose estimate has been emphasized, particularly in rapid assessment of large numbers of individuals who may be exposed to IR through acts of terrorism or by accident. A practical strategy to estimate radiation dose and triage victims based upon clinical symptomatology is presented. An explosion of knowledge has occurred regarding molecular and cellular pathways that trigger and mediate hematologic responses to IR. In addition to damaging DNA, IR alters gene expression and transcription, and interferes with intracellular and intercellular signaling pathways. The clinical expression of these disturbances may be the development of leukemia, the most significant hematologic complication of IR exposure among survivors of the atomic bomb detonations over Japan. Those at greatest risk for leukemia are individuals exposed during childhood. The association of leukemia with chronic, low-dose-rate exposure from nuclear power plant accidents and/or nuclear device testing has been more difficult to establish, due in part to lack of precision and sensitivity of methods to assess doses that approach background radiation dose. Nevertheless, multiple myeloma may be associated with chronic exposure, particularly in those exposed at older ages. PMID:12063018

  3. Radiation exposure from nuclear energy

    International Nuclear Information System (INIS)

    The information booklet contains the following papers which were already reported: 1) Scientific advisory committee of the German Bundesaerztekammer (medical board): Statement on the subject hazard by nuclear power plants (Deutsches Aerzteblatt - Aerztliche Mitteilung 1975, p. 2821 et sequ.). 2) Recommendation of the German Commission on Radiological Protection dated from Feb. 19, 1976: On the toxicity of inhaled hot particles, especially plutonium. 3) Statement of the German Commission on Radiological Protection dated from Dec. 16, 1976: Comparability of natural radiation exposure with the exposure from nuclear facilities. 4) Report of the German Federal Goverment on Environmental radioactivity and radiation exposure in the year of 1975 (Bundestagsdrucksache 8/311 dated from Apr 22, 1977). (orig./HP)

  4. Radiation exposure during equine radiography

    International Nuclear Information System (INIS)

    All personnel present in the X-ray examination room during equine radiography were monitored using low energy direct reading ionization chambers (pockets dosimeters) worn outside the lead apron at neck level. The individuals' task and dosimeter readings were recorded after each examination. Average doses ranged from 0 to 6 mrad per study. The greatest exposures were associated with radiography of the shoulder and averaged less than 4 mrad. The individual extending the horse's limb was at greatest risk although the individual holding the horse's halter and the one making the X-ray exposure received similar exposures. A survey of the overhead tube assembly used for some of the X-ray examinations also was performed. Meter readings obtained indicated an asymetric dose distribution around the tube assembly, with the highest dose occurring on the side to which the exposure cord was attached. Although the exposures observed were within acceptable limits for occupational workers, we have altered our protocol and no longer radiograph the equine shoulder unless the horse is anesthetized. Continued use of the pocket dosimeters and maintenance of a case record of radiation exposure appears to make the technologists more aware of radiation hazards

  5. Monitoring of occupational radiation exposures

    International Nuclear Information System (INIS)

    The most widely used tool for occupational radiation exposure monitoring is a badge worn on the trunk to measure Hp(10) and Hp(0.07) of photon radiation. Monitoring of exposure to beta and neutron radiations is performed for about 20% and 5%, respectively, of the workers occupationally exposed to radiation. Monitoring for internal deposition of radionuclides is, in general, less well regulated, and the results of internal dosimetry programmes are scarcely available. Dose to workers can also be determined from the results of workplace monitoring. In the case of aircrews, dose is normally computed on the basis of data on cosmic radiation fields and flight profiles. New techniques are emerging for the individual monitoring of external radiation. Active and passive electronic dosimeter systems are providing new dimensions for dosimetry and data handling, including direct dose readout capabilities and application of modern data networks. A number of problems remain to be solved. Neutron and beta dosimeters are not yet fully satisfactory. Internal dosimetry, still the subject of major research activities, has a need for more standardized routine programmes and systematic reporting. Monitoring for naturally occurring radioactive materials has to be improved and included in existing programmes. For global exchange, standards on dose record formats, and most particularly, unique quantities and units, are indispensable. (author)

  6. The influence of chronic exposure to increased doses of sodium fluoride and ionizing radiation on antioxidant state and energy metabolism in the liver of animals

    International Nuclear Information System (INIS)

    The influence of chronic fluoride intoxication and ionizing radiation on antioxidant state and energy metabolism in the liver of animals was studied. The investigation involved 50 white Wistar male rats. γ-irradiation and increased consumption of NaF disturb synthesis of RNA, globulins and gistons, decrease the concentration of cAMP in the liver. All this disturbances are due to the action of γ-irradiation as well as NaF, but the action of γ-irradiation is more pronounced

  7. Diagnostic and therapeutic radiation exposure

    International Nuclear Information System (INIS)

    Diagnostic and therapeutic radiology were studied as possible contaminants in the evaluations of A-bomb survivors in the ABCC-JNIH Adult Health Study for radiation effects. Hiroshima and Nagasaki subjects received X-ray examinations elsewhere within three months of their ABCC visits at rates of 23 and 12%, respectively. Medical X-ray examinations were more frequent among survivors than comparison subjects. Hiroshima and Nagasaki radiologic practice steadily increased since 1948, and differed markedly by city. From 1946-70 the Hiroshima and Nagasaki X-ray bone marrow doses were 2,300 and 1,000 g-rads, respectively. By 1970, cumulated medical X-ray doses approximated A-bomb doses at distances from the hypocenters of 2,000 m in Hiroshima and 2,800 m in Nagasaki. ABCC X-ray examination doses per subject are routinely updated for comparison with A-bomb doses. Each subject's reported fluoroscopy, photofluorography and radiation therapy exposure elsewhere are for future reference. Dental radiography, though increasing, was not currently an important contributor to survivors' overall exposure. Radiation therapy exposures of 137 subjects were confirmed, and doses estimated for most. Two-thirds the treatments were for malignancies; therapy differed markedly by city; and five cancers possibly arose from earlier radiation therapy. This underscores the importance of considering diagnostic and therapeutic radiology when attributing diseases to the atomic bombs. (auth.)

  8. Hereditary effects of low and chronic radiation exposure: a case-control study of mental retardation and cleft lip/palate in the monazite bearing coastal areas of Southern Kerala

    International Nuclear Information System (INIS)

    The high level natural radiation (HLNR) areas of Kerala in the south west coast of Kerala is suitable for direct human studies to assess the genetic and teratogenic effect of low and chronic radiation exposures. The radiation level in the region (about 55 km long and 0.5 km wide belt) range from ≤1.0 mGy to 45.0 mGy per year and is due to natural deposit of monazite sand containing Thorium (8-10%), Uranium (0.3%) and corresponding decay products. A population based case-control study was carried out in the area to assess the role, if any, of HLNR as a causative factor in the etiology of two relatively frequent and easily identifiable congenital malformations, viz., mental retardation (MR) and cleft lip/palate (CLP). Findings from the study are discussed in this paper

  9. Radiation exposure and occupational disease

    International Nuclear Information System (INIS)

    The knowledge about ionising radiation and the compensation of occupational diseases were both improved during the past 50 years. Now, the adverse effects of the radiation can be compensated by two ways: the disease of a claimant is automatically recognised as an occupational disease if all the criteria of the 'sixth table' are fulfilled. When all the previous criteria are not fulfilled, the 'Comites regionaux de reconnaissance en maladie professionnelle' have to estimate the relationship between the usual exposure and the disease. The decisions of the Comites are implicitly based on the probability of causation., However, the non specificity of the diseases, the influence of non occupational factors and the role of low doses lead to uncertainty of risk estimates and probability of causation. The compensation system has to be improved and has to remain consistent whatever the occupational exposure. (author)

  10. Prenatal radiation exposure. Dose calculation

    International Nuclear Information System (INIS)

    The unborn child requires special protection. In this context, the indication for an X-ray examination is to be checked critically. If thereupon radiation of the lower abdomen including the uterus cannot be avoided, the examination should be postponed until the end of pregnancy or alternative examination techniques should be considered. Under certain circumstances, either accidental or in unavoidable cases after a thorough risk assessment, radiation exposure of the unborn may take place. In some of these cases an expert radiation hygiene consultation may be required. This consultation should comprise the expected risks for the unborn while not perturbing the mother or the involved medical staff. For the risk assessment in case of an in-utero X-ray exposition deterministic damages with a defined threshold dose are distinguished from stochastic damages without a definable threshold dose. The occurrence of deterministic damages depends on the dose and the developmental stage of the unborn at the time of radiation. To calculate the risks of an in-utero radiation exposure a three-stage concept is commonly applied. Depending on the amount of radiation, the radiation dose is either estimated, roughly calculated using standard tables or, in critical cases, accurately calculated based on the individual event. The complexity of the calculation thereby increases from stage to stage. An estimation based on stage one is easily feasible whereas calculations based on stages two and especially three are more complex and often necessitate execution by specialists. This article demonstrates in detail the risks for the unborn child pertaining to its developmental phase and explains the three-stage concept as an evaluation scheme. It should be noted, that all risk estimations are subject to considerable uncertainties.

  11. Radiation exposure in diagnostic medicine

    International Nuclear Information System (INIS)

    This volume includes the manuscripts of the papers read at the conference as well as a summary and assessment of its results. The scientific discussions were centred upon the following issues: - International surveys and comparisons of rdiation exposures in diagnostic radiology and nuclear medicine, frequency of the individual diagnostic procedures and age distribution of patients examined; - policies and regulations for the radiation protection of patients, charcteristic dosimetric values and practical usefulness of the effective dose concept during medical examinations; - assessments of the relative benefits and risks and measures to reduce the radiation exposure in the light of quality assurance aspects. The main objective of this conference not only was to evaluate the risks from diagnostic radiology and nuclear medicine but also to encourgage a critical analysis and adjustment of examination routines followed in everyday practice. Among the measures recommended were quality assurance, maintenace of international standards, development of guidelines, introduction of standard doses, improved training and professional education of personnel as well as surveys and analyses of certain examination procedures associated with substantial radiation exposure. (orig./MG)

  12. Radiation exposure in coronary intervention

    Energy Technology Data Exchange (ETDEWEB)

    Furuta, Motomu [Kokura Memorial Hospital, Kitakyushu, Fukuoka (Japan)

    1999-01-01

    Percutaneous transluminal coronary angioplasty (PTCA) based on plain old balloon angioplasty is the representative surgery in cardiac interventional radiography, which, with accompanying the increase of patients, causing the serious exposure problem to patients and staff. Recent progress in PTCA practice owes to the development of new devices like the stent with which reduction of exposure dose has been somewhat attained due to the short operation time. Further, standardization of the operation procedure helps to shorten the time. In author`s facility, the pulse fluoroscopy stands from four modes: low-dose, normal, high-quality and slow ones. In these modes, the exposure dose, not the irradiation dose, is taken into consideration according to the FDA concept. The respective modes resulted in the reduction to 33, 70, 70 and 50% of the ordinary fluoroscopy skin dose (12.96 mGy/min: 1.49 R/min). As for exposure to operating staff, the scattering radiation was measured with the DIGITEX 2400 CX apparatus, WAC water phantom and VICTOREEN 450 ionization chamber survey meters and with shielding curtains and lead-acryl board. Shielding was found important for reduction of exposure to the staff. (K.H.)

  13. Occupational radiation exposures in Cyprus

    International Nuclear Information System (INIS)

    For the first time ever the occupational radiation exposure data of all the radiation workers of Cyprus, as obtained by the personnel monitoring service of the Dosimetry Laboratory of the Medical Physics Department of the Ministry of Health, is published and compared with that of other countries. The presented data shows a systematic trend of improvement both with regards to the methodology of monitoring and data recording. The efforts of the past few years in educating and training the users of ionising radiation with regards to the importance of the personnel monitoring service and the hazards of ionising radiation, has paid off and this is evident from the doses recorded in the past three years which are compared favourably with those of other countries, as given by the UNSCEAR 1993 report. The introduction of extremity monitoring, promises even better improvement in the methodology of monitoring the doses received by personnel working in Interventional Radiology, as well as other groups whose hands, unavoidably, come close to radiation sources. (authors)

  14. DNA alterations and effects on growth and reproduction in Daphnia magna during chronic exposure to gamma radiation over three successive generations

    International Nuclear Information System (INIS)

    Highlights: • We exposed three successive generations of Daphnia magna to chronic gamma radiation. • We examined DNA alterations and effects on survival, growth and reproduction. • DNA alterations were accumulated over a generation and transmitted to the progeny. • Effects on survival and reproduction, and delay in growth increased over generations. - Abstract: This study examined chronic effects of external Cs-137 gamma radiation on Daphnia magna exposed over three successive generations (F0, F1 and F2) to environmentally relevant dose rates (ranging from 0.007 to 35.4 mGy h−1). Investigated endpoints included survival, growth, reproduction and DNA alterations quantified using random-amplified polymorphic DNA polymerase chain reaction (RAPD-PCR). Results demonstrated that radiation effects on survival, growth and reproduction increased in severity from generation F0 to generation F2. Mortality after 21 days at 35.4 mGy h−1 increased from 20% in F0 to 30% in F2. Growth was affected by a slight reduction in maximum length at 35.4 mGy h−1 in F0 and by reductions of 5 and 13% in growth rate, respectively, at 4.70 and 35.4 mGy h−1 in F2. Reproduction was affected by a reduction of 19% in 21 day-fecundity at 35.4 mGy h−1 in F0 and by a delay of 1.9 days in brood release as low as 0.070 mGy h−1 in F2. In parallel, DNA alterations became significant at decreasing dose rates over the course of F0 (from 4.70 mGy h−1 at hatching to 0.007 mGy h−1 after ∼21 days) and from F0 to F2 (0.070 mGy h−1 at hatching to 0.007 mGy h−1 after ∼21 days), demonstrating their rapid accumulation in F0 daphnids and their transmission to offspring generations. Transiently more efficient DNA repair leading to some recovery at the organism level was suggested in F1, with no effect on survival, a slight reduction of 12% in 21 day-fecundity at 35.4 mGy h−1 and DNA alterations significant at highest dose rates only. The study improved our understanding of long term

  15. Chronic radiation disease. Consequences and outcomes

    International Nuclear Information System (INIS)

    Chronic Radiation Disease (CRD), induced by chronic external gamma-irradiation in cumulative dose 1.0-10.0 Gy ever a period of employment from 7 months to 7 years was described for the atomic enterprise workers during adjustment of that enterprise (1948-54). Key clinical syndromes of CRD were cytopenia in the peripheral blood (decrease of a number of thrombocytes, leukocytes, neutrophils to 50-60% from an initial level), changes in the nervous system (vegetative-vascular dysfunction of the hypotonic type, asthenic syndrome and at a cumulative dose more than 4.0 Gy - demyelinatied encephalomyelosis). The annual medical examination allowed assessing consequences of CRD for long-term period of monitoring (35-40 years) of 632 workers. By 10-15 years after termination of an exposure the characteristics of the peripheral blood are reverted to initial level (before employment at enterprise). However even by 40th year of observation in a part of cases the moderate hypoplasia of bone marrow (7.3%) and partial hypoplasia granulocytopoiesis (4.3%) is diagnosed. In lymphocytes of the peripheral blood the frequency of chromosome aberrations 4-5 times greater than a spontaneous level. Decrease of parameters of T-cell immunity remains. In cases of high exposure doses (cumulative dose more than 3.5-4.0 Gy) the early cerebral atherosclerosis (not older than 45) was diagnosed. By 40th year of monitoring the radiation cataracts were not detected. During the first decade of monitoring prevailing causes of death were an acute myeloid leukemia, during subsequent 30 years of monitoring - lung cancer was prevailing causes of death for worker who had contact with plutonium 239. (author)

  16. Unintentional exposure to ultraviolet radiation

    International Nuclear Information System (INIS)

    To evaluate the risks from unintentional exposure to ultraviolet radiation (UVR), and to consider hazard control regulation, one must face first the problem of their state of scientific knowledge and the public's perception of UVR. Few people in the general public would question the health benefits of sunlight. Many flock to the beaches each summer to develop a healthy tan. Since the 1920's scientists have recognized that most of the benefits--and risks--of sunlight exposure result from the UVR present in sunlight. Dermatologists warn sunbathers to avoid exposure or protect themselves against the intense midday UVR or risk skin cancer. A growing number of scientists warn of hazards to the eye if UVR--perhaps even shorter visible wavelengths--are not filtered by lenses. In addition to any intentional exposure for health or cosmetic purposes, many people are also exposed to UVR without being aware of it or without their intent to be exposed. Outdoor workers are exposed to sunlight, many industrial workers (e.g., welders) are exposed to UVR from arc sources, some UVR penetrates clothing, and people indoors are exposed to UVR from artificial lighting

  17. Studies on chronic effect on radiation

    International Nuclear Information System (INIS)

    This experiment was carried out to evaluate the chronic harzard of Co-60 low dose irradiation on ICR mice. There is now considerable evidence from human studies that age, both at exposure to radiation and at observation for risk, can be a major determinant of radiation induced cancer risk. For this reason, ICR mice at different ages as specified below were exposed to 60 m rads/week, 500 m rads/biweek of whole body Co-60 radiation at a dose rate of 3.6 rads/min. ICR mice were irradiated during pregnant period and each period from the 1st week to the 3rd week to the 52nd week, from the 6th week to the 52nd week and from the 22nd week to the 52nd week after the birth. All the experimental mice were autopsied immediately after sacrificed at the 52nd week. And all of their major organs were examined grossly and weighed. After fixation histo-pathological preparations were made for microscopical study. Blood cells-W.B.C., R.B.C., Hb-from eye's vein were counted by hemocytometer and hemometer. (Author)

  18. Effect of Chronic Exposure to Acidic Environment on Radiosensitivity of Gliosarcoma Cells

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sora; Kim, Eunhee [Seoul National Univ., Seoul (Korea, Republic of)

    2014-05-15

    In this study, the chronic exposure of cells to acid culture medium, prior or posterior to irradiation, has been investigated for its effect on clonogenic cell survival. Unconventional high-dose radiation therapy, such as SRS, SBRT and MRT, may cause severe vascular damage in tumors, thereby a number of tumor cells facing chronic hypoxia and thus acidosis. According to our observation, gliosarcoma cells become more vulnerable to radiation damage by chronic exposure to acidic condition before irradiation. The longer the preirradiation exposure is, the more vulnerable to radiation damage the cells become. However, the repair of PLD by post-irradiation exposure to acid medium is efficient enough to eliminate the difference in number of the cells carrying PLDs due to different durations of preirradiation exposure to acidic condition.

  19. Influence of chronic hypoxia and radiation quality on cell survival

    International Nuclear Information System (INIS)

    The purpose of this study was to investigate the influence of chronic hypoxia and anoxia on cell survival after low- and high-linear energy transfer (LET) radiation, Chinese hamster ovary K1 (CHO-K1) cells were kept for 24 h under chronic hypoxia (94.5% N2; 5% CO2; 0.5% O2) or chronic anoxia (95% N2; 5% CO2). Irradiation was performed using 250 kVp X-rays or carbon ions with a dose average LET of 100 keV/μm either directly under the chronic oxygenation states, or at different time points after reoxygenation. Moreover, the cell cycle distribution for cells irradiated under different chronic oxic states was measured over 24 h during reoxygenation. The measurements showed a fairly uniform cell cycle distribution under chronic hypoxia, similar to normoxic conditions. Chronic anoxia induced a block in G1 and a strong reduction of S-phase cells. A distribution similar to normoxic conditions was reached after 12 h of reoxygenation. CHO cells had a similar survival under both acute and chronic hypoxia. In contrast, survival after irradiation under chronic anoxia was slightly reduced compared to that under acute anoxia. We conclude that, in hamster cells, chronic anoxia is less effective than acute anoxia in inducing radioresistance for both X-rays and carbon ions, whereas in hypoxia, acute and chronic exposures have a similar impact on cell killing. (author)

  20. Exposure to non ionizing radiations

    International Nuclear Information System (INIS)

    In the last years the exposure levels to electric, magnetic and electromagnetic fields of workers and citizens have dramatically increased due to the technological development as in the exemplar case of cellular phones. The object of this research concerns the biological evaluation of the risk from exposure to non ionizing radiations (NIR) by an opportunely designed biosensor based on immobilized Saccharomyces cerevisiae cells and by an amperometric transducer (Clark oxygen electrode). The results have been obtained by comparing the respiratory activities of exposed and not exposed yeast cells to NIR (at 900 MHz, frequency of the first generation cellular phones). The measurements have been performed by irradiation of the cells in a G-TEM chamber. The obtained results clearly show a decrease of the respiration activity of the irradiation cells in comparison with blank. This variation results to be proportional to the exposure time. Concerning reversibility of the damage it seems that the recovery of the initial conditions begins after 4 hours since the end of exposition and is complete within the following 48 hrs

  1. Radiation-associated chronic myelogenous leukaemia in younger people

    International Nuclear Information System (INIS)

    Chronic myelogenous leukaemia (CML) is known to be induced by exposure to ionizing radiation, as is acute leukaemia. However, CML has been recorded only rarely as a complication of radiation exposure early in life. During the period from 1973 to 1976, 75 patients with CML were admitted to Roswell Park Memorial Institute (RPMI). In addition, 64 patients admitted to RPMI previously were also available for study in 1973. Among 79 patients who were born after 1925, information regarding radiation exposure was obtained in 89%; 49 were interviewed and 21 responded to a mailed questionnaire. Consultation with parents was achieved in 52 of the 70 responding cases (74%). Replies were obtained from 15 of the 18 patients below the age of 25, and were confirmed by parents or siblings in all instances. Replies to the mailed questionnaire were obtained from 45 age- and sex-matched controls. In addition to two patients already known to have radiation exposure for treatment of malignant neoplasms, these inquiries yielded a total of nine patients with histories of radiation exposure for benign conditions. Three had therapeutic irradiation, two for thymic enlargement and one for eczema. Three had exposure in utero by pelvimetry. Two had diagnostic exposure during the perinatal period and one had occupational exposure as a nurse. Four of these patients were below the age of 25. All nine patients had the Ph' chromosome. The course of CML in these patients was not different from that of other patients with Ph' chromosome-positive CML without a history of radiation exposure. A history of radiation exposure was elicited in one-fourth of the younger patients (<25) in this study, compared with one of 45 age- and sex-matched controls without leukaemia (p<0.02)

  2. Risk assessment and management of radiofrequency radiation exposure

    Science.gov (United States)

    Dabala, Dana; Surducan, Emanoil; Surducan, Vasile; Neamtu, Camelia

    2013-11-01

    Radiofrequency radiation (RFR) industry managers, occupational physicians, security department, and other practitioners must be advised on the basic of biophysics and the health effects of RF electromagnetic fields so as to guide the management of exposure. Information on biophysics of RFR and biological/heath effects is derived from standard texts, literature and clinical experiences. Emergency treatment and ongoing care is outlined, with clinical approach integrating the circumstances of exposure and the patient's symptoms. Experimental risk assessment model in RFR chronic exposure is proposed. Planning for assessment and monitoring exposure, ongoing care, safety measures and work protection are outlining the proper management.

  3. Risk assessment and management of radiofrequency radiation exposure

    Energy Technology Data Exchange (ETDEWEB)

    Dabala, Dana [Railways Medical Clinic Cluj-Napoca, Occupational Medicine Department, 16-20 Bilascu Gheorghe St., 400015 Cluj-Napoca (Romania); Surducan, Emanoil; Surducan, Vasile; Neamtu, Camelia [National Institute for Research and Development of Isotopic and Molecular Technologies, 65-103 Donath St., 400293 Cluj-Napoca (Romania)

    2013-11-13

    Radiofrequency radiation (RFR) industry managers, occupational physicians, security department, and other practitioners must be advised on the basic of biophysics and the health effects of RF electromagnetic fields so as to guide the management of exposure. Information on biophysics of RFR and biological/heath effects is derived from standard texts, literature and clinical experiences. Emergency treatment and ongoing care is outlined, with clinical approach integrating the circumstances of exposure and the patient's symptoms. Experimental risk assessment model in RFR chronic exposure is proposed. Planning for assessment and monitoring exposure, ongoing care, safety measures and work protection are outlining the proper management.

  4. Risk assessment and management of radiofrequency radiation exposure

    International Nuclear Information System (INIS)

    Radiofrequency radiation (RFR) industry managers, occupational physicians, security department, and other practitioners must be advised on the basic of biophysics and the health effects of RF electromagnetic fields so as to guide the management of exposure. Information on biophysics of RFR and biological/heath effects is derived from standard texts, literature and clinical experiences. Emergency treatment and ongoing care is outlined, with clinical approach integrating the circumstances of exposure and the patient's symptoms. Experimental risk assessment model in RFR chronic exposure is proposed. Planning for assessment and monitoring exposure, ongoing care, safety measures and work protection are outlining the proper management

  5. DNA alterations and effects on growth and reproduction in Daphnia magna during chronic exposure to gamma radiation over three successive generations

    Energy Technology Data Exchange (ETDEWEB)

    Parisot, Florian [Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PRP-ENV/SERIS/LECO, Cadarache, St Paul-lez-Durance 13115 (France); Bourdineaud, Jean-Paul [UMR 5805 EPOC – OASU, Station marine d’Arcachon, Université Bordeaux 1, Arcachon 33120 (France); Plaire, Delphine; Adam-Guillermin, Christelle [Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PRP-ENV/SERIS/LECO, Cadarache, St Paul-lez-Durance 13115 (France); Alonzo, Frédéric, E-mail: frederic.alonzo@irsn.fr [Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PRP-ENV/SERIS/LECO, Cadarache, St Paul-lez-Durance 13115 (France)

    2015-06-15

    Highlights: • We exposed three successive generations of Daphnia magna to chronic gamma radiation. • We examined DNA alterations and effects on survival, growth and reproduction. • DNA alterations were accumulated over a generation and transmitted to the progeny. • Effects on survival and reproduction, and delay in growth increased over generations. - Abstract: This study examined chronic effects of external Cs-137 gamma radiation on Daphnia magna exposed over three successive generations (F0, F1 and F2) to environmentally relevant dose rates (ranging from 0.007 to 35.4 mGy h{sup −1}). Investigated endpoints included survival, growth, reproduction and DNA alterations quantified using random-amplified polymorphic DNA polymerase chain reaction (RAPD-PCR). Results demonstrated that radiation effects on survival, growth and reproduction increased in severity from generation F0 to generation F2. Mortality after 21 days at 35.4 mGy h{sup −1} increased from 20% in F0 to 30% in F2. Growth was affected by a slight reduction in maximum length at 35.4 mGy h{sup −1} in F0 and by reductions of 5 and 13% in growth rate, respectively, at 4.70 and 35.4 mGy h{sup −1} in F2. Reproduction was affected by a reduction of 19% in 21 day-fecundity at 35.4 mGy h{sup −1} in F0 and by a delay of 1.9 days in brood release as low as 0.070 mGy h{sup −1} in F2. In parallel, DNA alterations became significant at decreasing dose rates over the course of F0 (from 4.70 mGy h{sup −1} at hatching to 0.007 mGy h{sup −1} after ∼21 days) and from F0 to F2 (0.070 mGy h{sup −1} at hatching to 0.007 mGy h{sup −1} after ∼21 days), demonstrating their rapid accumulation in F0 daphnids and their transmission to offspring generations. Transiently more efficient DNA repair leading to some recovery at the organism level was suggested in F1, with no effect on survival, a slight reduction of 12% in 21 day-fecundity at 35.4 mGy h{sup −1} and DNA alterations significant at highest

  6. Radiation exposure of airplane crews. Exposure levels

    International Nuclear Information System (INIS)

    Even at normal height levels of modern jet airplanes, the flying crew is exposed to a radiation level which is higher by several factors than the terrestrial radiation. There are several ways in which this can be hazardous; the most important of these is the induction of malignant growths, i.e. tumours. (orig./MG)

  7. Chronic myelogenous leukemia (CML)

    Science.gov (United States)

    CML; Chronic myeloid leukemia; Chronic granulocytic leukemia; Leukemia - chronic granulocytic ... nuclear disaster. It takes many years to develop leukemia from radiation exposure. Most people treated for cancer ...

  8. DNA alterations and effects on growth and reproduction in Daphnia magna during chronic exposure to gamma radiation over three successive generations.

    Science.gov (United States)

    Parisot, Florian; Bourdineaud, Jean-Paul; Plaire, Delphine; Adam-Guillermin, Christelle; Alonzo, Frédéric

    2015-06-01

    This study examined chronic effects of external Cs-137 gamma radiation on Daphnia magna exposed over three successive generations (F0, F1 and F2) to environmentally relevant dose rates (ranging from 0.007 to 35.4 mGy h(-1)). Investigated endpoints included survival, growth, reproduction and DNA alterations quantified using random-amplified polymorphic DNA polymerase chain reaction (RAPD-PCR). Results demonstrated that radiation effects on survival, growth and reproduction increased in severity from generation F0 to generation F2. Mortality after 21 days at 35.4 mGy h(-1) increased from 20% in F0 to 30% in F2. Growth was affected by a slight reduction in maximum length at 35.4 mGy h(-1) in F0 and by reductions of 5 and 13% in growth rate, respectively, at 4.70 and 35.4 mGy h(-1) in F2. Reproduction was affected by a reduction of 19% in 21 day-fecundity at 35.4 mGy h(-1) in F0 and by a delay of 1.9 days in brood release as low as 0.070 mGy h(-1) in F2. In parallel, DNA alterations became significant at decreasing dose rates over the course of F0 (from 4.70 mGy h(-1) at hatching to 0.007 mGy h(-1) after ∼21 days) and from F0 to F2 (0.070 mGy h(-1) at hatching to 0.007 mGy h(-1) after ∼21 days), demonstrating their rapid accumulation in F0 daphnids and their transmission to offspring generations. Transiently more efficient DNA repair leading to some recovery at the organism level was suggested in F1, with no effect on survival, a slight reduction of 12% in 21 day-fecundity at 35.4 mGy h(-1) and DNA alterations significant at highest dose rates only. The study improved our understanding of long term responses to low doses of radiation at the molecular and organismic levels in a non-human species for a better radioprotection of aquatic ecosystems. PMID:25840277

  9. A new radiation exposure record system

    International Nuclear Information System (INIS)

    The Hanford Radiological Records Program (HRRP) serves all Hanford contractors as the single repository for radiological exposure for all Hanford employees, subcontractors, and visitors. The program administers and preserves all Hanford radiation exposure records. The program also maintains a Radiation Protection Historical File which is a historical file of Hanford radiation protection and dosimetry procedures and practices. Several years ago DOE declared the existing UNIVAC mainframe computer obsolete and the existing Occupational Radiation Exposure (ORE) system was slated to be redeveloped. The new system named the Radiological Exposure (REX) System is described in this document

  10. Ambient radiation exposure: measurements and effects

    International Nuclear Information System (INIS)

    A brief review of the available literature, data and reports of various radiation exposure and protection studies and various measurements techniques are presented. A linear quadratic model has been given illustrating the validity of radiation hormesis

  11. Chronic fatigue syndrome following a toxic exposure.

    Science.gov (United States)

    Racciatti, D; Vecchiet, J; Ceccomancini, A; Ricci, F; Pizzigallo, E

    2001-04-10

    Chronic fatigue syndrome (CFS) is a clinical entity characterized by severe fatigue lasting more than 6 months and other well-defined symptoms. Even though in most CFS cases the etiology is still unknown, sometimes the mode of presentation of the illness implicates the exposure to chemical and/or food toxins as precipitating factors: ciguatera poisoning, sick building syndrome, Gulf War syndrome, exposure to organochlorine pesticides, etc. In the National Reference Center for CFS Study at the Department of Infectious Diseases of 'G. D'Annunzio' University (Chieti) we examined five patients (three females and two males, mean age: 37.5 years) who developed the clinical features of CFS several months after the exposure to environmental toxic factors: ciguatera poisoning in two cases, and exposure to solvents in the other three cases. These patients were compared and contrasted with two sex- and age-matched subgroups of CFS patients without any history of exposure to toxins: the first subgroup consisted of patients with CFS onset following an EBV infection (post-infectious CFS), and the second of patients with a concurrent diagnosis of major depression. All subjects were investigated by clinical examination, neurophysiological and immunologic studies, and neuroendocrine tests. Patients exposed to toxic factors had disturbances of hypothalamic function similar to those in controls and, above all, showed more severe dysfunction of the immune system with an abnormal CD4/CD8 ratio, and in three of such cases with decreased levels of NK cells (CD56+). These findings may help in understanding the pathogenetic mechanisms involved in CFS. PMID:11327394

  12. Radiation Worker Protection by Exposure Scheduling

    OpenAIRE

    Blankenbecler, Richard

    2011-01-01

    The discovery of the protective adaptive response of cells to a low dose of radiation suggests applications to radiation worker/first responder protection. Its use in cancer radiotherapy has been discussed in a separate publication. This paper describes simple changes in scheduling that can make use of these beneficial adaptive effects for protection. No increase in total exposure is necessary, only a simple change in the timing of radiation exposure. A low dose of radiation at a sufficient d...

  13. Aircrew radiation exposure: sources-risks-measurement

    International Nuclear Information System (INIS)

    A short review is given on the actual aircrew exposure and its sources. The resulting risks for harmful effects to the health and discuss methods for in-flight measurements of exposure is evaluated. An idea for a fairly simple and economic approach to a practical, airborne active dosimeter for the assessment of individual crew exposure is presented. The exposure of civil aircrew to cosmic radiation, should not be considered a tremendous risk to the health, there is no reason for panic. However, being significantly higher than the average exposure to radiation workers, it can certainly not be neglected. As recommended by ICRP, aircrew exposure has to be considered occupational radiation exposure and aircrews are certainly entitled to the same degree of protection, as other ground-based radiation workers have obtained by law, since long time. (author)

  14. Medical exposure and the effects of radiation

    International Nuclear Information System (INIS)

    Radiation gives cracks to genes. The influence is divided into deterministic effect with a threshold value, and the stochastic effect (tumor and genetic effect) which increases according to the exposure amount. Although we are put to various non-artificial radiations, which we cannot be avoided, on the earth, the contamination by artificial radiation can be defended. Artificial radioactive exposure includes medical exposure and non-medical exposure for example by nuclear power plant. As to medical examinations using radiation, the inquiry about the radiation exposure is increasing after the occurrence of the first nuclear power plant disaster of Fukushima. While concern about non-medical radioactive exposure increases, the uneasiness to medical irradiation is also increasing. The dose limit by artificial radioactive exposure other than medical exposure is set up in order to prevent the influence on the health. While the dose limit of the public exposure is set to the lower value than the total dose of non-artificial exposure concerning of a safety margin for all people, the dose limit of medical exposure is not defined, since it is thought that medical irradiation has a benefit for those who receive irradiation. Making an effort to decrease the radiation dose in performing the best medical treatment is the responsibility with which we are burdened. (author)

  15. Tissue responses to radiation exposure in the lung

    International Nuclear Information System (INIS)

    This article provides an outline on the influences of radiation on the lung carcinogenesis. External and internal radiation exposures cause acute and late effects, such as pneumonia, pulmonary fibrosis and lung cancers in humans and experimental animals. The acute radiation pneumonia is lethal at a high dose, and the inflammatory response may progress for chronic fibrosis. High LET radiation exposures, such as internal exposure of alpha radionuclides and external exposure of neutron, are more effective for lung cancer induction than external exposure of low LET radiation. The lung cancers are classified into adenocarcinoma, squamous cell carcinoma and small cell carcinoma (human only), and radiation induces any of the cancers. The target cells of the lung cancers are considered as type 2 alveolar epithelial cells and Clara (secretory) cells for the adenocarcinoma, as basal cells for the squamous cell carcinoma and as pulmonary neuroendocrine cells for the small cell carcinoma. The recent studies are revealing molecular mechanisms of the radiation-induced lung cancer. (author)

  16. Chronic TiO2 nanoparticle exposure to a benthic organism, Hyalella azteca: Impact of solar UV radiation and material surface coatings on toxicity

    Science.gov (United States)

    The present study examined the chronic toxicity of TiO2 nanoparticles (nano-TiO2) to a representative benthic species, Hyalella azteca, using an industry standard, P25, and a coated nano-TiO2 used in commercial products. There is limited information on the chronic effects of nano...

  17. Thyroid cancer following exposure to ionising radiation

    International Nuclear Information System (INIS)

    Exposure to ionising radiations during childhood increases the risk of thyroid cancer. Similar risk factors have been found after external radiation exposure or internal contamination with radioactive iodine isotopes. In case of contamination with radio-iodines, administration of potassium iodide can prevent thyroid irradiation. (authors)

  18. Influences on radiation exposure in diagnostic radiology

    International Nuclear Information System (INIS)

    In 1,553 single examinations of 25 roentgendiagnostic procedures and measurements of interventional radiology, the patients' doses were determined. Influence of patient features and training of the radiologist for average radiation exposure were examined. Special control measurements examinations with highest radiation exposures showed up to 20% diminishing of dose. (orig.)

  19. DOE Occupational Radiation Exposure, 2001 report

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2001-12-31

    The goal of the U.S. Department of Energy (DOE) is to conduct its operations, including radiological, to ensure the safety and health of all DOE employees, contractors, and subcontractors. The DOE strives to maintain radiation exposures to its workers below administrative control levels and DOE limits and to further reduce these exposures to levels that are “As Low As Reasonably Achievable” (ALARA). The 2001 DOE Occupational Radiation Exposure Report provides a summary and analysis of the occupational radiation exposure received by individuals associated with DOE activities. The DOE mission includes stewardship of the nuclear weapons stockpile and the associated facilities, environmental restoration of DOE, and energy research.

  20. Sources of radiation exposure - an overview

    International Nuclear Information System (INIS)

    Sources of radiation exposure are reviewed from the perspective of mining and milling of radioactive ores in Australia. The major sources of occupational and public exposure are identified and described, and exposures from mining and milling operations are discussed in the context of natural radiation sources and other sources arising from human activities. Most radiation exposure of humans comes from natural sources. About 80% of the world average of the effective dose equivalents received by individual people arises from natural radiation, with a further 15-20% coming from medical exposures*. Exposures results from human activities, such as mining and milling of radioactive ores, nuclear power generation, fallout from nuclear weapons testing and non-medical use of radioisotopes and X-rays, add less than 1% to the total. 9 refs., 4 tabs., 10 figs

  1. DOE occupational radiation exposure 2006 report

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2006-12-31

    The U.S. Department of Energy (DOE) Office of Corporate Safety Analysis (HS-30) within the Office of Health, Safety and Security (HSS) publishes the annual DOE Occupational Radiation Exposure Report to provide an overview of the status of radiation protection practices at DOE. This report provides a summary and an analysis of occupational radiation exposure information for all monitored individuals associated with DOE activities. The occupational radiation exposure information is analyzed in terms of aggregate data, dose to individuals, and dose by site over the past five years.

  2. DOE occupational radiation exposure 2005 report

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2005-12-31

    The U.S. Department of Energy (DOE) Offi ce of Corporate Safety Analysis (HS-30) within the Office of Health Safety and Security (HSS) publishes the annual DOE Occupational Radiation Exposure Report to provide an overview of the status of radiation protection practices at DOE. This report provides a summary and an analysis of occupational radiation exposure information for all monitored individuals associated with the DOE activities. The occupational radiation exposure information is analyzed in terms of aggregate data, dose to individuals, and dose by site over the past 5 years.

  3. Radiation exposure in fetal and childhood period

    International Nuclear Information System (INIS)

    After East Japan earthquake of March 2011 and Fukushima Daiichi nuclear power plant accident, much more attention has been paid against radiation exposure. Children are much more radiosensitive than adults for radiation exposure. Biological radiation effect has been studied and estimated primarily by using Hiroshima and Nagasaki data of the atomic bomb victims. And the effects of the long term low dose radiation and high dose exposure in the short term are not as well. Effects of radiation exposure in fetal period appear as miscarriage, malformation, and mental retardation. The estimated threshold is 100 mSv. On the other hand, there could be no threshold for the carcinogenesis as late effects of ionizing radiation. The risk of leukemia and solid cancers could be increased along with radiation exposure. Especially thyroid cancer in children increased after the Chernobyl accident. The linear no-threshold (LNT) model is based on the assumption that the risk is directly proportional to the dose at all dose levels, and forms the basis of the radiation protection of the International Commission of Radiological Protection (ICRP). This leads to ALARA concept, which is an acronym for ''As Low As Reasonably Achievable''. Herewith I introduce the concept of radiation protection with review of previous reports, and discuss how to minimize diagnostic radiation exposure. (author)

  4. DOE occupational radiation exposure 2007 report

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2007-12-31

    The U.S. Department of Energy (DOE) Office of Corporate Safety Analysis (HS-30) within the Office of Health, Safety and Security (HSS) publishes the annual DOE Occupational Radiation Exposure Report to provide an overview of the status of radiation protection practices at DOE.* The annual DOEOccupational Radiation Exposure 2007 Report provides an evaluation of DOE-wide performance regarding compliance with DOE Part 835 dose limits and ALARA process requirements. In addition the report provides data to DOE organizations responsible for developing policies for protection of individuals from the effects of radiation. This report provides a summary and an analysis of occupational radiation exposure information from the monitoring of individuals involved in DOE activities. The occupational radiation exposure information is analyzed in terms of aggregate data, dose to individuals, and dose by site over the past five years.

  5. Diagnosis of 20 cases with chronic radiation syndrome

    International Nuclear Information System (INIS)

    Twenty cases with chronic radiation syndrome were diagnosed in our department during 1957-1980. All except one were radiologists, and eight of them had worked in radiological departments for over 20 years. Owing to the use of out-dated x-ray machines as well as radium sources without adequate protection, all these cases were apparently overexposed to radiation. They presented following signs and symptoms of chronic radiation syndrome: excitability, palpitation, fatigue, general weakness, loss of weight, oversweating accompanied by tendency of lowered metabolism, peripheral blood cell changes, and chromosome aberrations. The diagnosis of this syndrome was based on definitive professional and over-exposure history, clinical picture and abnormal laboratory findings. (author)

  6. Acute radiation syndrome caused by accidental radiation exposure - therapeutic principles

    Directory of Open Access Journals (Sweden)

    Dörr Harald

    2011-11-01

    Full Text Available Abstract Fortunately radiation accidents are infrequent occurrences, but since they have the potential of large scale events like the nuclear accidents of Chernobyl and Fukushima, preparatory planning of the medical management of radiation accident victims is very important. Radiation accidents can result in different types of radiation exposure for which the diagnostic and therapeutic measures, as well as the outcomes, differ. The clinical course of acute radiation syndrome depends on the absorbed radiation dose and its distribution. Multi-organ-involvement and multi-organ-failure need be taken into account. The most vulnerable organ system to radiation exposure is the hematopoietic system. In addition to hematopoietic syndrome, radiation induced damage to the skin plays an important role in diagnostics and the treatment of radiation accident victims. The most important therapeutic principles with special reference to hematopoietic syndrome and cutaneous radiation syndrome are reviewed.

  7. The analysis of radiation exposure of hospital radiation workers

    International Nuclear Information System (INIS)

    This investigation was performed in order to improve the health care of radiation workers, to predict a risk, to minimize the radiation exposure hazard to them and for them to realize radiation exposure danger when they work in radiation area in hospital. The documentations checked regularly for personal radiation exposure in four university hospitals in Pusan city in Korea between January 1, 1993 and December 31, 1997 were analyz ed. There were 458 persons in this documented but 111 persons who worked less then one year were excluded and only 347 persons were included in this study. The average of yearly radiation exposure of 347 persons was 1.52±1.35 mSv. Though it was less than 5OmSv, the limitaion of radiation in law but 125 (36%) people received higher radiation exposure than non-radiation workers. Radiation workers under 30 year old have received radiation exposure of mean 1.87±1.01 mSv/year, mean 1.22±0.69 mSv between 31 and 40 year old and mean 0.97±0.43 mSv/year over, 41year old (p<0.001). Men received mean 1.67±1.54 mSv/year were higher than women who received mean 1.13±0.61 mSv/year (p<0.01). Radiation exposure in the department of nuclear medicine department in spite of low energy sources is higher than other departments that use radiations in hospital (p<0.05). And the workers who received mean 3.69±1.81 mSv/year in parts of management of radiation sources and injection of sources to patient receive high radiation exposure in nuclear medicine department (0<0.01). In department of diagnostic radiology high radiation exposure is in barium enema rooms where workers received mean 3.74±1.74 mSv/year and other parts where they all use fluoroscopy such as angiography room of mean 1.17±0.35 mSv/year and upper gastrointestinal room of mean 1.74±1.34 mSv/year represented higher radiation exposure than average radiation exposure in diagnostic radiology (p<0.01). Doctors and radiation technologists received higher radiation exposure of each mean 1.75±1

  8. Acute radiation syndrome caused by accidental radiation exposure - therapeutic principles

    OpenAIRE

    Dörr Harald; Meineke Viktor

    2011-01-01

    Abstract Fortunately radiation accidents are infrequent occurrences, but since they have the potential of large scale events like the nuclear accidents of Chernobyl and Fukushima, preparatory planning of the medical management of radiation accident victims is very important. Radiation accidents can result in different types of radiation exposure for which the diagnostic and therapeutic measures, as well as the outcomes, differ. The clinical course of acute radiation syndrome depends on the ab...

  9. Importance of reducing medical radiation exposure

    International Nuclear Information System (INIS)

    Medical exposure primarily refers to intentional irradiation of patients for diagnostic and therapeutic purposes. Among the man-made sources, diagnostic radiology is the major contributor of radiation dose to the public. This article (1) reviews the recommendations of International Commission of Radiological Protection pertaining to medical exposures, (2) stresses the importance of reducing exposure, (3) deals with the present status of medical exposure in India and (4) discusses the methodology for achieving reduction of medical exposure. Awareness, good equipment, safe work practices, discipline, trained personnel and continuing education will go a long way in achieving the goal of reduction of medical exposure. (author)

  10. Radiation effects in the offspring of chronically exposed parents

    International Nuclear Information System (INIS)

    In mice who had been chronically exposed to low levels of ionizing radiation before mating, the effect of these exposures on the offspring was examinated with special regard to early post-natal development, radiation resistance as well as the frequency of cytogenetic variations of bone-marrow cells. Furthermore, studies have been undertaken on the spontaneous incidence of cytogenetic aberrations in peripheral blood lymphocytes of newborns in two cities of the U.S.S.R., but no correlation could be found wih the gamma dose rates (5 - 50 μR/h) ascertained in the parental flats. (author)

  11. Health risks associated with environmental radiation exposures

    International Nuclear Information System (INIS)

    Much is known about health effects associated with exposure to ionising radiation. Numerous epidemiologic studies of populations exposed to radiation under a variety of circumstances have been conducted. These studies have clearly shown that radiation exposure can result in an increased risk of many types of cancer, and the findings are supported by a substantial body of literature from experimental studies. Despite the fact that radiation exposures from environmental sources comprise a relatively minor component of total population exposure, this type of exposure is often the most feared by the public. An accident like Chernobyl or a natural disaster like that at Fukushima provides a unique opportunity to learn more about the health risks from environmental radiation exposures. However, establishing the infrastructure and expertise required to design and conduct all aspects of a complex field study presents formidable challenges. This paper summarises the principal findings from the main studies of environmental radiation exposure that have been successfully undertaken. Although such studies are often exceedingly difficult to conduct, and may be limited by an ecologic design, they can be informative in assessing risk. Any new environmental study that is initiated should focus on special circumstances; additional ecological studies are not recommended. (note)

  12. Exposure to background radiation in Australia

    Energy Technology Data Exchange (ETDEWEB)

    Solomon, S.B. [Australian Radiation Lab., Melbourne, VIC (Australia)

    1997-12-31

    The average effective dose received by the Australian population is estimated to be {approx}1.8 mSv / year. One half of this exposure arises from exposure from terrestrial radiation and cosmic rays, the remainder from radionuclides within the body and from inhalation of radon progeny. This paper reviews a number of research programmes carried out by the Australian Radiation Laboratory to study radiation exposure from natural background, particularly in the workplace and illustrate approaches to the quantification and management of exposure to natural radiation. The average radiation doses to the Australian population are relatively low; the average annual radon concentration ranged from 6 Bq m{sup -3} in Queensland to 16 Bq m{sup -3} in the Australian Capital Territory (ACT). Of more importance is the emerging issue of exposure to elevated background radiation in the workplace. Two situation are presented; the radiation exposure to air crues and show cave tour guides. Annual doses up to 3.8 mSv were estimated for international crew members while the highest estimate for show cave tour guides was 9 mSv per year. 9 refs., 2 tabs., 4 figs.

  13. Exposure to background radiation in Australia

    International Nuclear Information System (INIS)

    The average effective dose received by the Australian population is estimated to be ∼1.8 mSv / year. One half of this exposure arises from exposure from terrestrial radiation and cosmic rays, the remainder from radionuclides within the body and from inhalation of radon progeny. This paper reviews a number of research programmes carried out by the Australian Radiation Laboratory to study radiation exposure from natural background, particularly in the workplace and illustrate approaches to the quantification and management of exposure to natural radiation. The average radiation doses to the Australian population are relatively low; the average annual radon concentration ranged from 6 Bq m-3 in Queensland to 16 Bq m-3 in the Australian Capital Territory (ACT). Of more importance is the emerging issue of exposure to elevated background radiation in the workplace. Two situation are presented; the radiation exposure to air crues and show cave tour guides. Annual doses up to 3.8 mSv were estimated for international crew members while the highest estimate for show cave tour guides was 9 mSv per year

  14. Monitoring occupational exposure to ionizing radiation

    International Nuclear Information System (INIS)

    A brief overview is presented of methods of monitoring occupational exposure to ionizing radiation together with reasons for such monitoring and maintaining dose histories of radiation occupationally exposed persons. The various Australian providers of external radiation monitoring services and the types of dosemeters they supply are briefly described together with some monitoring results. Biological monitoring methods, are used to determine internal radiation dose. Whole body monitors, used for this purpose are available at Australian Radiation Lab., ANSTO and a few hospitals. Brief mention is made of the Australian National Radiation Dose Register and its objectives

  15. Control of radiation exposure (principles and methods)

    International Nuclear Information System (INIS)

    Biological risks are directly related to the tissue radiation dose, so it is very important to maintain personnel doses as low as realistically possible. This goal can be achieved by minimizing internal contamination and external exposure to radioactive sources

  16. Radioactivity in water and radiation exposure

    International Nuclear Information System (INIS)

    The radiation exposure of man via waters is outlined. Natural as well as man-made radionuclides are taken into account, also considering the influence by man on the activity distribution in the environment. Relations between air and water pollution are treated. The measured values in hand do not indicate a significant increase of radiation exposure of man by man-made radionuclides in drinking water. The importance is discussed of international agreements in order to overcome environmental problems. (orig.)

  17. Occupational radiation exposures in Canada-1984

    International Nuclear Information System (INIS)

    This is the seventh in a series of annual reports on Occupational Radiation Exposures in Canada. The information is derived from the National Dose Registry of the Radiation Protection Bureau, Department of National Health and Welfare. As in the past this report presents by occupation: average yearly whole body doses by region, dose distributions, and variations of average doses with time. Statistical data concerning investigations of high exposures reported by the National Dosimetry Services are tabulated in summary form

  18. Occupational radiation exposures in Canada - 1987

    International Nuclear Information System (INIS)

    This is the tenth in a series of annual reports on Occupational Radiation Exposures in Canada. The information is derived from the National Dose Registry of the Bureau of Radiation and Medical Devices, Department of National Health and Welfare. This report presents by occupation average yearly whole body doses by region, dose distributions, and variations of the average doses with time. Statistical data concerning investigations of high exposures reported by the National Dosimetry Services are tabulated in summary form

  19. Occupational radiation exposure in Austria in 1979

    International Nuclear Information System (INIS)

    The Institute for Radiation Protection at the Research Center Seibersdorf operates since over three years an automatic TLD-personnel monitoring service comprising some 13000 radiation workers all over Austria who are generally monitored during monthly periods according to radiation legislation. All dose readings obtained by the system are stored on computer in a central dose register. Electronic data handling techniques can easily be used to obtain statistical information on radiation exposure for different user branches. The following data include distribution of monthly dose values for different branches, average monthly dose readings and occupational exposure of different groups of age. Due to the very large number of individual dose readings a statistically significant view of the occupational radiation exposure in Austria during 1979 can be obtained. (author)

  20. Retrospective internal radiation exposure assessment in occupational epidemiology

    International Nuclear Information System (INIS)

    Epidemiologic studies of workers at U.S. Department of Energy facilities are being conducted by the U.S. National Institute for Occupational Safety and Health to evaluate the health risk associated with exposure to sources of external and internal ionizing radiation. While exposure to external sources of radiation can be estimated from personal dosimeter data, reconstruction of exposure due to internally deposited radioactivity is more challenging because bioassay monitoring data is frequently less complete. Although comprehensive monitoring was provided for workers with the highest internal exposures, the majority of workers were monitored relatively infrequently. This monitoring was conducted to demonstrate compliance with regulations rather than to evaluate exposure for use in epidemiologic studies. Attributes of past internal monitoring programs that challenge accurate exposure assessment include: incomplete characterization of the workplace source term; a lack of timely measurements; insensitive and/or nonspecific bioassay measurements; and the presence of censored data. In spite of these limitations, many facilities have collected a large amount of worker and workplace monitoring information that can be used to evaluate internal exposure while minimizing worker misclassification. This paper describes a systematic approach for using the available worker and workplace monitoring data that can lead to either a qualitative or quantitative retrospective assessment of internal exposures. Various aspects of data analysis will be presented, including the evaluation of minimum detectable dose, the treatment of censored data, and the use of combinations of bioassay and workplace data to characterize exposures. Examples of these techniques applied to a cohort study involving chronic exposure scenarios to uranium are provided. A strategy for expressing exposure or dose in fundamental, unweighted units related to the quantity of radiation delivered to an organ will also

  1. Exposure of the orthopaedic surgeon to radiation

    International Nuclear Information System (INIS)

    We monitored the amount of radiation received by surgeons and assistants during surgery carried out with fluoroscopic assistance. The radiation was monitored with the use of MYDOSE MINIX PDM107 made by Aloka Co. Over a one year period from Aug 20, 1992 to Aug 19, 1993, a study was undertaken to evaluate exposure of the groin level to radiation with or without use of the lead apron during 106 operation (Group-1). In another group, radiation was monitored at the breast and groin level outside of the lead apron during 39 operations (Group-2). In Group-1, the average exposure per person during one year was 46.0 μSV and the average exposure for each procedure was 1.68 μSV. The use of the lead apron affirmed its protective value; the average radiation dose at the groin level out-side of the apron was 9.11 μSV, the measured dose beneath the apron 0.61 μSV. The average dose of exposure to the head, breast at groin level outside of the lead apron, were 7.68 μSV, 16.24 μSV, 32.04 μSV respectively. This study and review of the literature indicate that the total amount of radiation exposure during surgery done with fluoroscopic control remains well within maximum exposure limits. (author)

  2. Occupational exposure to microwave radiation in diathermia units

    Energy Technology Data Exchange (ETDEWEB)

    Martinez, M.A.; Ubeda, A. [Hospital Ramon y Cajal, Servicio de Investigacion-BEM, Madrid (Spain); Tellez, M.; Santa Olalla, I. [Hospital La Paz, Servicio de Radiofisica y Radioproteccion, Madrid (Spain)

    2006-07-01

    The present study summarizes preliminary data addressed to complete the present knowledge on the microwave (M.V.)-exposure doses and conditions in workers exposed chronically to relatively high, though nonthermal, levels of that non ionizing radiations (N.I.R.). The obtained data are of direct application to radiation protection in occupational media provided that: 1) help to detect and eradicate practices and situations that result in overexposure; 2) they constitute a basis for the design and development of strategies for exposure control and minimization, and 3) they represent a dosimetric support necessary to properly interpret past and future epidemiologic and experimental data on potential health effects of chronic exposures to M.W. radiation at work. The described results will be extended through additional dosimetric recordings in other hospitals. The dosimetric data will be compared to the results of questionnaires among the electro-therapists working at the units studied. The objective is to identify potential relationships between exposure doses and specific diseases or level of risk perception among the investigated professional group. (authors)

  3. Occupational exposure to microwave radiation in diathermia units

    International Nuclear Information System (INIS)

    The present study summarizes preliminary data addressed to complete the present knowledge on the microwave (M.V.)-exposure doses and conditions in workers exposed chronically to relatively high, though nonthermal, levels of that non ionizing radiations (N.I.R.). The obtained data are of direct application to radiation protection in occupational media provided that: 1) help to detect and eradicate practices and situations that result in overexposure; 2) they constitute a basis for the design and development of strategies for exposure control and minimization, and 3) they represent a dosimetric support necessary to properly interpret past and future epidemiologic and experimental data on potential health effects of chronic exposures to M.W. radiation at work. The described results will be extended through additional dosimetric recordings in other hospitals. The dosimetric data will be compared to the results of questionnaires among the electro-therapists working at the units studied. The objective is to identify potential relationships between exposure doses and specific diseases or level of risk perception among the investigated professional group. (authors)

  4. Radiation effects after exposure during prenetal development

    International Nuclear Information System (INIS)

    The embryo and fetus are very radiosensitive during the total prenatal development period. The quality and extent of radiation effects depend strongly on the developmental stage at which the exposure occurs. During the preimplantation period radiation exposure can cause death of the embryo after radiation doses of 0.2 Gy and higher. Malformations are only observed in very rare cases when genetic predispositions exist. Macroscopic-anatomical malformations are induced only after irradiation during the major organogenesis. On the basis of experimental data with mammals it is assumed that a radiation dose of about 0.2 Gy doubles the malformation risk. Studies in humans give rise to the assumption that the human embryo is more radioresistant than the embryos of mice and rats. Radiation exposure during the major organogenesis and the early fetal period lead to disturbances in the growth and developmental processes. During early fetogenesis (week 8-15 post coruption) high radiosensitity exists for the development of the central nervous system. Radiation doses of 1 Gy cause severe mental retardation in about 50% of exposed fetuses. Analysis of the dose-effect curves shows that there is probably a dose-effect curve with a threshold for this effect. It must be taken into account that radiation exposure during the fetal period also induces cancer. The studies, however, do not allow quantitative estimate of this radiation risk at present. It is therefore generally assumed that the risk is about the same level as for children. (orig.)

  5. Valuing the radiation detriment of occupational exposure

    International Nuclear Information System (INIS)

    The implications of changes in the radiation risk estimates on the valuation of radiation detriment for use in cost-benefit analysis are being considered at the National Radiological Protection Board. This paper discusses the pertinent factors that are currently being considered for further investigation. An example of relevance to occupational exposure is detailed. (author)

  6. Endoscopic management of chronic radiation proctitis

    Institute of Scientific and Technical Information of China (English)

    Tarun Rustagi; Hiroshi Mashimo

    2011-01-01

    Chronic radiation proctopathy occurs in 5%-20% of patients following pelvic radiotherapy. Although many cases resolve spontaneously, some lead to chronic symptoms including diarrhea, tenesmus, urgency and persistent rectal bleeding with iron deficiency anemia requiring blood transfusions. Treatments for chronic radiation proctitis remain unsatisfactory and the basis of evidence for various therapies is generally insufficient. There are very few controlled or prospective trials, and comparisons between therapies are limited because of different evaluation methods. Medical treatments, including formalin, topical sucralfate, 5-amino salicylic acid enemas, and short chain fatty acids have been used with limited success. Surgical management is associated with high morbidity and mortality. Endoscopic therapy using modalities such as the heater probe, neodymium:yttrium-aluminium-garnet laser, potassium titanyl phosphate laser and bipolar electrocoagulation has been reported to be of some benefit, but with frequent complications. Argon plasma coagulation is touted to be the preferred endoscopic therapy due to its efficacy and safety profile. Newer methods of endoscopic ablation such as radiofrequency ablation and cryotherapy have been recently described which may afford broader areas of treatment per application, with lower rate of complications.This review will focus on endoscopic ablation therapies, including such newer modalities, for chronic radiation proctitis.

  7. Cosmic radiation exposure to airline flight passenger

    International Nuclear Information System (INIS)

    At the high altitudes, airline flight passengers can be exposed to some levels of cosmic radiation. The purpose of this study was to quantify this radiation exposure. Cosmic radiation was measured during 5 flights using a personal dosimeter (PDM-102, Aloka). Cosmic radiation equivalent dose rates ranged from 0.7 to 1.43 microsieverts per hour, the average rate was 1.08. For the passenger who travels only occasionally, the cosmic radiation levels are well below occupational limits, and the risks are extremely small. (author)

  8. Occupational radiation exposures in Canada - 1980

    International Nuclear Information System (INIS)

    This report is the third in a series of annual reports on Occupational Radiation Exposures in Canada. The data is derived from the Radiation Protection Bureau's National Dose Registry which includes dose records for radiation workers. The report presents average yearly doses by region and occupational category, dose distributions, and variation of average doses with time. Statistical data concerning investigations of high exposures reported by the National Dosimetry Services are included and individual cases are briefly summarized where the maximum permissible dose is exceeded. The decrease in the overall average doses established over the last 20 years appears to be changing. In some occupational categories a consistent upward trend is observed

  9. Occupational radiation exposures in Canada - 1982

    International Nuclear Information System (INIS)

    This report is the fifth in a series of annual reports in Occupational Radiation Exposures in Canada. The data is derived from the Radiation Protection Bureau's National Dose Registry which contains dose records for radiation workers. The report presents average yearly doses by region and occupational category, dose distributions, and variation of average doses with time. Statistical data concerning investigations of high exposures reported by the National Dosimetry Services are included, and individual cases are briefly summarized where the maximum permissible dose is exceeded

  10. Radiation exposure modeling and project schedule visualization

    International Nuclear Information System (INIS)

    This paper discusses two applications using IGRIP (Interactive Graphical Robot Instruction Program) to assist environmental remediation efforts at the Department of Energy (DOE) Hanford Site. In the first application, IGRIP is used to calculate the estimated radiation exposure to workers conducting tasks in radiation environments. In the second, IGRIP is used as a configuration management tool to detect interferences between equipment and personnel work areas for multiple projects occurring simultaneously in one area. Both of these applications have the capability to reduce environmental remediation costs by reducing personnel radiation exposure and by providing a method to effectively manage multiple projects in a single facility

  11. Radiation exposure modeling and project schedule visualization

    Energy Technology Data Exchange (ETDEWEB)

    Jaquish, W.R.; Enderlin, V.R. [ICF Kaiser Hanford Co., Richland, WA (United States)

    1995-10-01

    This paper discusses two applications using IGRIP (Interactive Graphical Robot Instruction Program) to assist environmental remediation efforts at the Department of Energy (DOE) Hanford Site. In the first application, IGRIP is used to calculate the estimated radiation exposure to workers conducting tasks in radiation environments. In the second, IGRIP is used as a configuration management tool to detect interferences between equipment and personnel work areas for multiple projects occurring simultaneously in one area. Both of these applications have the capability to reduce environmental remediation costs by reducing personnel radiation exposure and by providing a method to effectively manage multiple projects in a single facility.

  12. Bases for establishing radiation exposure limits

    International Nuclear Information System (INIS)

    It is an essential requirement of good radiation protection that all unnecessary exposure of people should be avoided and that any necessary exposure, whether of workers or of members of the general public, should be minimized. It is, however, an additional requirement that such necessary exposures should not exceed certain stated limits. These principles are based on the possibility that even the smallest exposures may involve some risk of harm, that any risk of harm should be justifiable by the circumstances necessitating it, and that risk should always be limited to an appropriately low level. The bases for establishing exposure limits must therefore involve an assessment of the risk involved in any form of radiation exposure, and an opinion as to the degree of safety that should be ensured in circumstances which necessitate any occupational or public exposure to radiation. There is increasing quantitative evidence on the frequency on which harm, and particularly the induction of malignancies, may be caused in people exposed to radiation at high doses; and somewhat clearer bases than previously for inferring the possible frequencies at low doses. It is therefore easier to assess the degree of safety ensured by restricting radiation exposure to particular levels. It is clear also that a comparable degree of safety should be ensured whether the radiation exposure involves the whole body more of less uniformly, or individual tissues or organs selectively. The ''weighting'' factors appropriate to irradiation of particular tissues from internal emitters can thus be defined in terms of their likely individual contributions to the harm of whole-body irradiation. In this way the limits for different modes of exposure by external or internal radiation can be related so as to ensure that protection should be equally effective for different distributions of absorbed dose in the body. In particular, the over-simplified concept of a single critical organ determining the

  13. Risks and management of radiation exposure.

    Science.gov (United States)

    Yamamoto, Loren G

    2013-09-01

    High-energy ionizing radiation is harmful. Low-level exposure sources include background, occupational, and medical diagnostics. Radiation disaster incidents include radioactive substance accidents and nuclear power plant accidents. Terrorism and international conflict could trigger intentional radiation disasters that include radiation dispersion devices (RDD) (a radioactive dirty bomb), deliberate exposure to industrial radioactive substances, nuclear power plant sabotage, and nuclear weapon detonation. Nuclear fissioning events such as nuclear power plant incidents and nuclear weapon detonation release radioactive fallout that include radioactive iodine 131, cesium 137, strontium 90, uranium, plutonium, and many other radioactive isotopes. An RDD dirty bomb is likely to spread only one radioactive substance, with the most likely substance being cesium 137. Cobalt 60 and strontium 90 are other RDD dirty bomb possibilities. In a radiation disaster, stable patients should be decontaminated to minimize further radiation exposure. Potassium iodide (KI) is useful for iodine 131 exposure. Prussian blue (ferric hexacyanoferrate) enhances the fecal excretion of cesium via ion exchange. Ca-DTPA (diethylenetriaminepentaacetic acid) and Zn-DTPA form stable ionic complexes with plutonium, americium, and curium, which are excreted in the urine. Amifostine enhances chemical and enzymatic repair of damaged DNA. Acute radiation sickness ranges in severity from mild to lethal, which can be assessed by the nausea/vomiting onset/duration, complete blood cell count findings, and neurologic symptoms. PMID:24201986

  14. Routine medicare and radiation exposure. Introductory remarks

    International Nuclear Information System (INIS)

    As an introduction of the title series, outlines of radiation in physics, chemistry, biochemistry, biological effect and protection are explained from the clinical doctors' aspect of routine medicare, and of radiation exposure in which people's interest is raised after the Fukushima Nuclear Power Plant Accident in 2011. For physics, ionizing effects of radiation are described in relation to its quantum energy transfer and its medical utilization like imaging and radiotherapy. Then mentioned in brief is the radiation from elements consisting of human body, cosmic ray and background radiation from the earth, with reference to natural and standardized limits of exposure doses. Radiations from 226Rn and 40K are explained as an instance of environmental natural sources together with the concepts of radioactive decay series/scheme, of internal exposure, of hazard like double strand break (DSB) and of medical use such as boron neutron capture therapy (BNCT). For an artifact radiation source, shown are fission products of 235U by neutron, first yielded in 1945. Evidence of evolution in biochemical repair mechanisms of DSB is explained with a comparison of irradiated drosophila mutation where linear non-threshold (LNT) hypothesis is proposed, and human non-homologous end joining and homologous recombination. Historical process of occupational, medical, public exposures and their protection is finally described from the discovery of X-ray in 1895 to the first ICRP publication in 1958 via the A-bomb explosion in 1945. (T.T.)

  15. Radiation exposure management - The Westinghouse ALARA program

    International Nuclear Information System (INIS)

    Westinghouse has incorporated radiation management into the design of its NSSS plants. This paper describes the Westinghouse program for incorporating As Low As Reasonably Achievable (ALARA) radiation exposure into the design process. A description is given of the method of collecting data from operating Westinghouse plants. The analysis of this data and its use in the total NSSS plant exposure estimate is presented. Application of a detailed exposure review to the development of an improved mechanical component is described. A particular exposure review for a refueling task is discussed. One high exposure task is detailed and specific design improvements are identified. The disadvantages of the existing design are expressed and design improvements are suggested. The matrix management of the team that develops the improved design is described and the resulting product is presented. The specific example is used to illustrate the operation of the Westinghouse ALARA program

  16. Radiation Exposure According to Radiation Technologist' Working Departments

    International Nuclear Information System (INIS)

    Radiation dose to radiologists working at three hospitals in Seoul was investigated from Jan 1, 2006 to Dec. 31, 2006. The results are as follows. First, radiation dose to radiologists at a cardiac angiography room was measured as 1.41 mSv, the highest while radiation dose to radiologists at a department of radiation oncology was measured as 0.64 mSv, the lowest. Second, radiation dose proves to be in direct proportion to the number of X-ray treatment. Third, as for the radiation dose in X-ray treatments, radiologists in cardiac angiography room are exposed to the largest amount of radiation while radiologists in diagnostic radiology department are exposed to the smallest amount of radiation. Last, radiation dose at a cardiac angiography room is the largest and is followed by nuclear medicine, diagnostic radiology, and radiation oncology departments in order. According to ICRP, exposure less than 20 mSv per year is highly recommended while radiation dose is allowed as long as it is ranged less than 50 mSv per year or 100 mSv within a 5-year period. Taking into account the results, radiation exposure does not do any harm to radiologists at any related departments in Korean hospitals because the dose per year is less than 1.60 mSv.

  17. Prenatal radiation exposure policy: A labor arbitration

    International Nuclear Information System (INIS)

    A policy on prenatal radiation exposure at two nuclear power plants was revised to give better assurance of compliance with NCRP recommendations on fetal radiation exposure. This action was taken after publication of NCRP 91 in June 1987 to provide better assurance that a total dose equivalent limit to an embryo-fetus be no greater than 0.5 mSv (0.05 rem) in any month and no more than 5 mSv (500 mrem) for a gestation period. For any female worker to receive radiation exposure greater than 1.5 mSv (0.15 rem) in a month at these nuclear power plants, she was asked to initiate an administrative request for radiation exposure in excess of this limit. In this request, she was asked to acknowledge that she was aware of the guidance in U.S. NRC Regulatory Guide 8.13. A worker who had the potential for radiation exposure in excess of 1.5 mSv (0.15 rem) refused to process this request and was consequently denied overtime work. She filed a grievance for denial of overtime, and this grievance was submitted for labor arbitration in June 1988. The arbitration decision and its basis and related NRC actions are discussed

  18. Radiation risk due to occupational exposure

    International Nuclear Information System (INIS)

    Exposure to ionizing radiation occurs in many occupations. Workers can be exposed to both natural and artificial sources of radiation. Any exposure to ionizing radiation incurs some risk, either to the individual or to the individual's progeny. This dissertation investigated the radiation risk due to occupational exposure in industrial radiography. Analysis of the reported risk estimates to occupational exposure contained in the UNSCEAR report of 2008 in industrial radiography practice was done. The causes of accidents in industrial radiography include: Lack of or inadequate regulatory control, inadequate training, failure to follow operational procedures, human error, equipment malfunction or defect, inadequate maintenance and wilful violation have been identified as primary causes of accidents. To minimise radiation risks in industrial radiography exposure devices and facilities should be designed such that there is intrinsic safety and operational safety ensured by establishing a quality assurance programme, safety culture fostered and maintained among all workers, industrial radiography is performed in compliance with approved local rules, workers engaged have appropriate qualifications and training, available safe operational procedures are followed, a means is provided for detecting incidents and accidents and an analysis of the causes and lessons learned. (author)

  19. EPIC database on the effects of chronic radiation in fish: Russian/FSU data

    International Nuclear Information System (INIS)

    The paper presents the extraction of data from the EPIC database, outlining the effects of chronic radiation exposure in fish. The EPIC database 'Radiation effects on aquatic biota' is compiled as part of the current EC Project EPIC (Environmental Protection from Ionizing Contaminants in the Arctic). The EPIC database is based on information from publications in Russian (Russian/former Soviet Union data). The data are focused on the effects in fish at relatively low doses of chronic radiation exposure. The effects are grouped by three key endpoints: morbidity, reproduction, and mortality/life shortening. A preliminary scale of dose-effects relationships for fish has been constructed

  20. Array-CGH analysis of mouse malignant lymphomas. Effects of chronic exposure to low-dose-rate γ-radiation on tumorigenesis

    International Nuclear Information System (INIS)

    We previously reported that mice that were chronically irradiated with γ-rays at low dose rates had significantly shorter life spans than unirradiated controls. The major cause of this life-shortening is considered to be the earlier onset and/or the faster progression of malignant lymphomas in the irradiated groups. In this study, chromosomal aberrations in a total of 54 malignant lymphomas from mice irradiated with a dose rate of 21 mGy/day and nonirradiated mice were precisely compared by microarray-based comparative genomic hybridization (array-CGH) analysis. Array-CGH profiles showed that about two-thirds of the tumors had aneuploidy genotypes, in which numeric aberrations of chromosomes 12, 14, 15, 16, and X were observed frequently in the unirradiated group while that of chromosome 15 predominated in the irradiated group. In addition, copy-number alterations were frequently identified on partial chromosomal regions harboring the following oncogenes and tumor suppressor genes: c-myc, N-myc, notch-1, notch-2, hes-1, akt-1, akt-2, akt-3, bcl-6, bcl-10, bcl-11a, bcl-11b, pim-2, BCoR, XIAP, rhoE, p16INK4a, p15INK4b, p73, p27Kip1, RB, and pten. If aberrations extending across whole-chromosomal and partial-chromsomal regions are counted together, gains on chromosomes 3, 12, 13, 14, 16 and X can be associated preferentially with the unirradiated group, whereas gains on chromosome 15, along with losses on chromosomes 4 and 14, were detected more frequently in the irradiated group. These observations offer insights into how low-dose-rate irradiation caused the earlier onset and/or the faster progression of tumors, as well as into the molecular pathogenesis of murine lymphomas. (author)

  1. Biological effects and hazards of radiation exposure

    International Nuclear Information System (INIS)

    Radiation induced carcinogenesis and mutagenesis form the main risk to health from exposure to low levels of radiation. This risk effects can be at least qualitatively understood by considering the effects of radiation on cell DNA. Whilst exposure to high levels of radiation results in a number of identifiable effects, exposure to low levels of radiation may result in effects which only manifest themselves after many years. Risk estimates for low levels of radiation have been derived on the basis of a number of assumptions. In the case of uranium mine workers a major hazard arises from the inhalation of radon daughters. Whilst the correlation between radon daughter exposure and lung cancer incidence is well established, the numerical value of the risk factor is the subject of controversy. ICRP 50 gives a value of 10 cases per 106 person-years at risk per WLM (range 5-15 x 10-6 PYR-1 WLM-1). The effect of smoking on lung cancer incidence rates amongst miners is also controversial. Nevertheless, smoking by miners should be discouraged

  2. Radiation exposure from civil aviation

    International Nuclear Information System (INIS)

    The question as to whether civil air crews and frequent air passengers ought to be classified among the group of occupationally exposed persons has in principle been decided by the recommendations adopted by the ICRP, the competent bodies of the EU, and national authorities. Measurements for more information on the radiation fields involved are planned. The German Radiation Protection Office (BfS) recently published a statement on dose commitments, assuming a maximum annual dose of approx. 8 mSv in addition to the mean value already determined. Legal provisions, which ought to be adopted also on EU level since civil aviation is a transboundary traffic system, have yet to come. (orig./HP)

  3. Sensitivity of Trout to Chronic Acute Exposure to Selenium

    DEFF Research Database (Denmark)

    Nielsen, Gunnar Gissel; Nielsen, M. Gissel

    1978-01-01

    Trout were exposed to selenite (Na2SeO3) solutions of varying concentrations (0.1-100 ppm Se) for periods of up to 4 wk. A chronic exposure to 0.1 ppm Se or less is non-lethal to trout. Lethality at higher concentrations depends on the length of exposure. Trout that survive for 10 days in tap...

  4. Case of child abuse by radiation exposure

    International Nuclear Information System (INIS)

    On 2 May 1974, a father was convicted of castrating his 13-year-old son by exposing him to a 1-curie source of 137Cs to be used for oil gas well logging. The child was subjected to perhaps eight exposures or attempted exposures over a six-month period. A brief discussion of the medical descriptions of the radiation effects upon the skin and testes and the chromosomal system is included

  5. European study of occupational radiation exposure (ESOREX)

    International Nuclear Information System (INIS)

    The European Study of Occupational Radiation Exposure (ESOREX) project was initiated by the general directive EC DG XI and carried out by the Bundesamt fuer Strahlenschutz, Germany (BfS). It consists of surveys carried out in the 28 European states. The study provides comparable description of the national administrative structures used to monitor and register individual occupational radiation exposure and the national dose statistics. It will establish the basis for identifying differences between the states and assessing the possibilities for European harmonisation. (author)

  6. Occupational radiation exposures in canada-1983

    International Nuclear Information System (INIS)

    This is the sixth in a series of annual reports on Occupational Radiation Exposures in Canada. The information is derived from the National Dose Registry of the Radiation Protection Bureau, Department of National Health and Welfare. As in the past this report presents by occupation: average yearly whole body doses by region, dose distributions, and variations of the average doses with time. The format has been changed to provide more detailed information regarding the various occupations. Statistical data concerning investigations of high exposures reported by the National Dosimetry Services are tabulated in summary form

  7. Radiation exposure in nucleomedical examinations of children

    International Nuclear Information System (INIS)

    The problem of radiation exposure must be subjected to particularly careful scrutiny in nuclear diagnostic procedures in children. The contribution provides a survey of factors influencing the radiation exposure of children in the diagnostic use of radionuclides. These include the age of the child examined, the type of radiopharmaceutical used, the dose of the radiopharmaceutical and the procedure followed. Any state-of-the-art renal function study or skeletal examination using radionuclides requires previous measures to ensure that the child is sufficiently hydrated. The tables in the appendix provide estimations of the doses from the individual nucleomedical procedures used in paediatrics. (orig./MG)

  8. Radiation exposure from radium-226 ingestion

    International Nuclear Information System (INIS)

    The contribution of radium to total radiation exposure resulting from the consumption of natural levels of 226Ra in several public water supplies in an Oklahoma county was determined. A pilot-level study of total dietary intake indicated that the culinary use of water anomalously high in radium and the consumption of water-based beverages contributed significantly to radiation exposure. The mean dietary intake of 226Ra was 20.6 pCi/day in one community and resulted in an estimated bone dose of 310 mrem/year

  9. Evaluation of the oxidative stress modulation in Drosophila melanogaster strains deficient in endogenous antioxidants and with chronic exposure to casiopeina Cas II-gly and gamma radiation

    International Nuclear Information System (INIS)

    The casiopeinas are a family of coordination compounds with copper metallic center that have shown to have antineoplastic activity. The experimental evidences suggest that its action mechanism is through the generation of free radicals. The casiopeina (Cas II-gly) is believed to causes oxidative damage in the mitochondria, leading to the cellular death. The present study has the purpose to evaluate the antioxidant potential of the tetrapyrroles: cupro-sodica chlorophyllin (CSC), protoporphyrin-Ix (Pp-Ix) and the bilirubin (Bili) against the oxidant action of the Cas II-gly. The present study will also contribute in the characterization of the biological activity of the Cas II-gly. For this purpose is quantifies the effect of these compounds in the enzymes activity, superoxide dismutase (Sod) and catalase (Cat) in wild Drosophila melanogaster strains Canton-S and in the deficient in Sod and Cat. Two protocols were used, in the first male of 1-24 h of age were pre-treated with 0, 0.01, 0.1 and 1 m M of Cas II-gly and later on they were treated with radiation (15 Gy), and the second 69 m M of CSC, Pp-Ix or Bili, during 8 days and later they were treated with 0.1 m M of Cas II-gly during 24 h. The enzymatic activity was measured with the detection packages of enzymes Sod and Cat of Sigma. It was found that none of the three pigments increment the Sod activity but, if they diminished that of Cat (p≤0.007). The three concentrations of Cas II-gly did not increase the Sod activity significantly, only the concentration of 0.1 m M diminishes in 5.6 U the Cat activity (p <0.03) the same as the treatment with 15 Gy of gamma rays (8 U, p <0.004). The Cas II-gly combination 0.1 m M with the pigments does not modify the Sod and Cat activity. These results suggest that the proven pigments act as antioxidants, avoiding the induction of exogenous antioxidants caused by the gamma rays or the Cas II-gly. (Author)

  10. DOE occupational radiation exposure 1996 report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-31

    The goal of the US Department of Energy (DOE) is to conduct its radiological operations to ensure the health and safety of all DOE employees including contractors and subcontractors. The DOE strives to maintain radiation exposures to its workers below administrative control levels and DOE limits and to further reduce these exposures and releases to levels that are ``As Low As Reasonably Achievable`` (ALARA). The DOE Occupational Radiation Exposure Report, 1996 provides summary and analysis of the occupational radiation exposure received by individuals associated with DOE activities. The DOE mission includes stewardship of the nuclear weapons stockpile and the associated facilities, environmental restoration of DOE and precursor agency sites, and energy research. Collective exposure at DOE has declined by 80% over the past decade due to a cessation in opportunities for exposure during the transition in DOE mission from weapons production to cleanup, deactivation and decommissioning, and changes in reporting requirements and dose calculation methodology. In 1996, the collective dose decreased by 10% from the 1995 value due to decreased doses at five of the seven highest-dose DOE sites. For 1996, these sites attributed the reduction in collective dose to the completion of several decontamination and decommissioning projects, reduced spent fuel storage activities, and effective ALARA practices. This report is intended to be a valuable tool for managers in their management of radiological safety programs and commitment of resources.

  11. DOE occupational radiation exposure 1996 report

    International Nuclear Information System (INIS)

    The goal of the US Department of Energy (DOE) is to conduct its radiological operations to ensure the health and safety of all DOE employees including contractors and subcontractors. The DOE strives to maintain radiation exposures to its workers below administrative control levels and DOE limits and to further reduce these exposures and releases to levels that are ''As Low As Reasonably Achievable'' (ALARA). The DOE Occupational Radiation Exposure Report, 1996 provides summary and analysis of the occupational radiation exposure received by individuals associated with DOE activities. The DOE mission includes stewardship of the nuclear weapons stockpile and the associated facilities, environmental restoration of DOE and precursor agency sites, and energy research. Collective exposure at DOE has declined by 80% over the past decade due to a cessation in opportunities for exposure during the transition in DOE mission from weapons production to cleanup, deactivation and decommissioning, and changes in reporting requirements and dose calculation methodology. In 1996, the collective dose decreased by 10% from the 1995 value due to decreased doses at five of the seven highest-dose DOE sites. For 1996, these sites attributed the reduction in collective dose to the completion of several decontamination and decommissioning projects, reduced spent fuel storage activities, and effective ALARA practices. This report is intended to be a valuable tool for managers in their management of radiological safety programs and commitment of resources

  12. Occupational radiation exposures in Canada - 1994

    International Nuclear Information System (INIS)

    This is the seventeenth in a series of annual reports on Occupational Radiation Exposures in Canada. The information is derived from the National Dose Registry of the Radiation Protection Bureau, Health Canada. As in the past, this report presents the following data by occupation: average yearly whole body doses by region, dose distributions, and variations of the average doses with time. (author). 17 refs., 4 tabs., 3 figs

  13. What happens at very low levels of radiation exposure ? Are the low dose exposures beneficial ?

    International Nuclear Information System (INIS)

    Full text: Radiation is naturally present in our environment and has been since the birth of this planet. The human population is constantly exposed to low levels of natural background radiation, primarily from environmental sources, and to higher levels from occupational sources, medical therapy, and other human-mediated events. Radiation is one of the best-investigated hazardous agents. The biological effects of ionizing radiation for radiation protection consideration are grouped into two categories: The deterministic and the stochastic ones. Deterministic radiation effects can be clinically diagnosed in the exposed individual and occur when above a certain thresholdan appropriately high dose is absorbed in the tissues and organs to cause the death of a large number of cells and consequently to impair tissue or organ functions early after exposure. A clinically observable biological effect (Acute Radiation Sendromes, ARS) occurs days to months after an acute radiation dose. Stochastic radiation effects are the chronic effects of radiation result from relatively low exposure levels delivered over long periods of time. These are sort of effects that might result from occupational exposure, or to the background exposure levels. Such late effects might be the development of malignant (cancerous) disease and of the hereditary consequences. These effects may be observed many years after the radiation exposure. There is a latent period between the initial radiation exposure and the development of the biological effect. For this reason, a stochastic effect is called a Linear or Zero-Threshold (LNT) Dose-Response Effect. There is a stochastic correlation between the number of cases of cancers or genetic defects developed inside a population and the dose received by the population at relatively large levels of radiation. These changes in gene activation seem to be able to modify the response of cells to subsequent radiation exposure, termed the adaptive response. This

  14. Aircrew radiation exposure assessment for Yugoslav airlines

    International Nuclear Information System (INIS)

    The presented study shows that the crews of the intercontinental flights can receive significant annual effective doses (1.5-2.0 mSv). The exposure of the crews is comparable with natural radiation level on the ground level (it can be up to 5 times higher for some air crew members in the intercontinental flights), but smaller than maximum permissible dose for general population. The annual exposures of the passengers are generally smaller than the exposures of tile air crews. because the passengers have a limited number of flights per year compared with the members of the air-crews. (author)

  15. Natural radiation exposure modified by human activities

    International Nuclear Information System (INIS)

    We are now living in the radiation environment modified by our technology. It is usually called 'Technologically Enhanced Natural Radiation' and have been discussed in the UNSCEAR Reports as an important source of exposure. The terrestrial radionuclide concentrations as well as the intensity of cosmic rays are considered to have been constant after our ancestors came down from trees and started walking on their two feet. However, we have been changing our environment to be more comfortable for our life and consequently ambient radiation levels are nomore what used to be. In this paper exposures due to natural radiation modified by our following activities are discussed: housing, balneology, cave excursion, mountain climbing, skiing, swimming, smoking and usage of mineral water, well water, coal, natural gas, phosphate rocks and minerals. In the ICRP Publication No. 39, it is clearly mentioned that even natural radiation should be controlled as far as it is controllable. We have to pay more attention to our activities not to enhance the exposure due to unnecessary, avoidable radiation. (author)

  16. Minimizing Patient Exposure to Radiation in Gastrointestinal Imaging

    International Nuclear Information System (INIS)

    Many diagnostic imaging examinations in gastroenterology involve exposure to ionizing radiation. These procedures include plain radiography, barium studies, nuclear medicine studies, computed tomography (CT), interventional radiology procedures, and procedures performed under fluoroscopy guidance in an endoscopy suite (e.g. endoscopic retrograde cholangiopancreatography). Radiation protection is vital for all procedures performed under fluoroscopy guidance, including those performed in the endoscopy suite. Radiation protection in the endoscopy suite should follow published guidelines from the International Commission on Radiological Protection and the World Gastroenterology Organisation, which specifically address the issue of radiation protection for fluoroscopically guided procedures performed outside imaging departments and in the endoscopy suite. Recent studies have examined the issue of lifetime cumulative effective doses received by patients attending hospital with gastrointestinal disorders and have shown potential for substantial radiation exposures from gastrointestinal imaging, especially in small groups of patients with chronic gastrointestinal disorders such as Crohn’s disease. In these studies, CT is the major contributor to cumulative dose. In these patients, radiation dose optimization is necessary and should follow the principles of justification, optimization and limitation. (author)

  17. Exposure to UV radiation and human health

    Science.gov (United States)

    Kimlin, Michael G.

    2005-08-01

    This paper will overview the significant issues facing researchers in relating the impact of exposure to sunlight and human health. Exposure to solar ultraviolet radiation is the major causative factor in most sun-related skin and eye disorders, however, very little is known quantitatively about human UV exposures. Interestingly, human exposure to sunlight also has a nutritional impact, namely the development of pre-Vitamin D, which is an important nutrient in bone health. New research suggest that low vitamin D status may be a causative factor in the development of selective types of cancer and autoimminue diseases, as well as a contributing factor in bone health. The 'health duality' aspect of sunlight exposure is an interesting and controversial topic that is a research focus of Kimlin's research group.

  18. TELOMERASE AND CHRONIC ARSENIC EXPOSURE IN HUMANS

    Science.gov (United States)

    Arsenic exposure has been associated with increased risk of skin, lung and bladder cancer in humans. The mechanisms of carcinogenesis are not well understood. Telomerase, a ribonucleoprotein containing human telomerase reverse transcriptase (hTERT), can extend telomeres of eukary...

  19. Realtime radiation exposure monitor and control apparatus

    International Nuclear Information System (INIS)

    This patent application relates to an apparatus and methods used to obtain image information from modulation of a uniform flux. An exposure measuring apparatus is disclosed which comprises a multilayered detector structure having an external circuit connected to a transparent insulating layer and to a conductive plate a radiation source adapted to irradiate the detector structure with radiation capable of producing electron-hole pairs in a photoconductive layer of the detector wherein the flow of current within the external circuit is measured when the detector is irradiated by the radiation source. (author)

  20. Radiation exposure through radiopharmaceuticals in routine diagnostics

    International Nuclear Information System (INIS)

    So far proof is lacking that nuclear medical examinations have somatic or genetic radiation effects. The radioiodine test is a category apart, on account of its involving a high radiation exposure of the relatively exposed thyroid and because it has already been carried through on many patients. Recommendations for radiation hygiene can therefore only relate to the careful ascertainment of indications (e.g. skeletal scintigraphy in pre-school children), the dosage of the activity to be applied, the choice of the collimator, minimization of the bladder dose and quality controls carried out a.o. on equipment and radiopharmaceuticals. (DG)

  1. Possibilities to reduce radiation exposure during radiography in small animal practice

    International Nuclear Information System (INIS)

    Veterinarians may suffer from chronic radiation injuries if exposed consistently to small doses of x-rays over a long period of years. Such injuries can positively be avoided by using accurate techniques. This paper makes suggestions how veterinary radiologists can reduce the radiation exposure by following very simple precautions

  2. Pituitary tumors following fallout radiation exposure

    International Nuclear Information System (INIS)

    Two pituitary tumors were diagnosed in a small population of Marshallese accidentally exposed to radioactive fallout in 1954. Endocrinologic findings in the exposed population, are reported and the possible relation of the tumors to radiation exposure and thyroid disease is discussed

  3. Radiation exposure in interventional radiology

    Energy Technology Data Exchange (ETDEWEB)

    Pinto, N.G.V. [Nuclear Instrumentation Laboratory, COPPE-UFRJ, P.O. Box 68509, Rio de Janeiro 21945-970 (Brazil)], E-mail: nivia@lin.ufrj.br; Braz, D. [Nuclear Instrumentation Laboratory, COPPE-UFRJ, P.O. Box 68509, Rio de Janeiro 21945-970 (Brazil); Vallim, M.A. [Department of Radioprotection, IEN-UFRJ, Cidade Universitaria, Ilha do Fundao, Rio de Janeiro (Brazil); Filho, L.G.P.; Azevedo, F.S. [Clementino Fraga Filho Universitary Hospital, UFRJ, Rio de Janeiro 21941-590 (Brazil); Barroso, R.C. [Physics Institute, University of Rio de Janeiro State, Rio de Janeiro 20559-900 (Brazil); Lopes, R.T. [Nuclear Instrumentation Laboratory, COPPE-UFRJ, P.O. Box 68509, Rio de Janeiro 21945-970 (Brazil)

    2007-09-21

    The aim of this study is to evaluate dose values in patients and staff involved in some interventional radiology procedures. Doses have been measured using thermoluminescent dosemeters for single procedures (such as renal and cerebral arteriography, transjungular intrahepatic portasystemic shunt (TIPS) and chemoembolization). The magnitude of doses through the hands of interventional radiologists has been studied. Dose levels were evaluated in three points for patients (eye, thyroid and gonads). The dose-area product (DAP) was also investigated using a Diamentor (PTW-M2). The dose in extremities was estimated for a professional who generally performed one TIPS, two chemoembolizations, two cerebral arteriographies and two renal arteriographies in a week. The estimated annual radiation dose was converted to effective dose as suggested by the 453-MS/Brazil norm The annual dose values were 137.25 mSv for doctors, 40.27 mSv for nurses and 51.95 mSv for auxiliary doctors, and all these annual dose values are below the limit established. The maximum values of the dose obtained for patients were 6.91, 10.92 and 15.34 mGy close to eye, thyroid and gonads, respectively. The DAP values were evaluated for patients in the same interventional radiology procedures. The dose and DAP values obtained are in agreement with values encountered in the literature.

  4. Radiation exposure mitigation through food

    International Nuclear Information System (INIS)

    137CsCl2 was incorporated into plants (tomyao and broccoli) and these homogenized solutions were administered to rats. The whole-body retention was determined with an Armac counter. The whole body retention patterns of 137Cs incorporated into the plants were not significantly different from that of the 137CsCl2 solution. Chitosan is derived from chitin, which is a cellulose-like biopolymer distributed widely in nature, especially in crustaceans, insects, fungi and yeast. The present study was to investigate whether chitosan can be applied to animal and human bodies in order to reduce the bioavailability of radio-iron and -zinc in food. Chitosan inhibits dietary iron absorption only when rats eat on iron-deficient diet. The effectiveness of phytate (myo-inositol 1,2,3,4,5,6-hexakis dihydrogen phosphate) and chitosan in reducing the bioavailability of radio-zinc depend on the concentration of phytate and chitosan. Recently, the share of imported foods increased ca. 40% of Japanese total food consumption. Radioactivities in imported foods must be checked from the viewpoints of internal radiation for Japanese subjects. Concentrations of 232Th and 238U in some imported mineral waters were higher than domestic waters. However, internal doses of portable waters are negligible. Individual foodstuffs in major food groups (fish and shellfish, meats, mushrooms, root vegetables and so on), which contributed to some radionuclide intakes in Japanese, were also analyzed to clarify the critical pathway in Japanese subjects. (author)

  5. Radiation exposure in interventional radiology

    Science.gov (United States)

    Pinto, N. G. V.; Braz, D.; Vallim, M. A.; Filho, L. G. P.; Azevedo, F. S.; Barroso, R. C.; Lopes, R. T.

    2007-09-01

    The aim of this study is to evaluate dose values in patients and staff involved in some interventional radiology procedures. Doses have been measured using thermoluminescent dosemeters for single procedures (such as renal and cerebral arteriography, transjungular intrahepatic portasystemic shunt (TIPS) and chemoembolization). The magnitude of doses through the hands of interventional radiologists has been studied. Dose levels were evaluated in three points for patients (eye, thyroid and gonads). The dose-area product (DAP) was also investigated using a Diamentor (PTW-M2). The dose in extremities was estimated for a professional who generally performed one TIPS, two chemoembolizations, two cerebral arteriographies and two renal arteriographies in a week. The estimated annual radiation dose was converted to effective dose as suggested by the 453-MS/Brazil norm The annual dose values were 137.25 mSv for doctors, 40.27 mSv for nurses and 51.95 mSv for auxiliary doctors, and all these annual dose values are below the limit established. The maximum values of the dose obtained for patients were 6.91, 10.92 and 15.34 mGy close to eye, thyroid and gonads, respectively. The DAP values were evaluated for patients in the same interventional radiology procedures. The dose and DAP values obtained are in agreement with values encountered in the literature.

  6. DOE occupational radiation exposure 1997 report

    Energy Technology Data Exchange (ETDEWEB)

    none,

    1997-12-31

    The U.S. Department of Energy (DOE) Office of Environment, Safety and Health publishes the DOE Occupational Radiation Exposure Report. This report is intended to be a valuable tool for DOE/DOE contractor managers in managing radiological safety programs and to assist them in prioritizing resources. We appreciate the efforts and contributions from the various stakeholders within and outside DOE and hope we have succeeded in making the report more useful. This report includes occupational radiation exposure information for all monitored DOE employees, contractors, subcontractors, and visitors. The exposure information is analyzed in terms of aggregate data, dose to individuals, and dose by site. For the purposes of examining trends, data for the past 5 years are included in the analysis.

  7. DOE occupational radiation exposure 1998 report

    Energy Technology Data Exchange (ETDEWEB)

    none,

    1998-12-31

    The U.S. Department of Energy (DOE) Office of Environment, Safety and Health with support from Environment Safety and Health Technical Information Services publishes the DOE Occupational Radiation Exposure Report. This report is intended to be a valuable tool for DOE/DOE contractor managers in managing radiological safety programs and to assist them in prioritizing resources. We appreciate the efforts and contributions from the various stakeholders within and outside DOE and hope we have succeeded in making the report more useful. This report includes occupational radiation exposure information for all monitored DOE employees, contractors, subcontractors, and visitors. The exposure information is analyzed in terms of aggregate data, dose to individuals, and dose by site. For the purposes of examining trends, data for the past 5 years are included in the analysis.

  8. DOE occupational radiation exposure 1996 report

    Energy Technology Data Exchange (ETDEWEB)

    none,

    1996-12-31

    The U.S. Department of Energy (DOE) Office of Environment, Safety and Health publishes the DOE Occupational Radiation Exposure Report. This report is intended to be a valuable tool for DOE/DOE contractor managers in their management of radiological safety programs and to assist them in the prioritization of resources. We appreciate the efforts and contributions from the various stakeholders within and outside the DOE and hope we have succeeded in making the report more useful. This report includes occupational radiation exposure information for all DOE employees, contractors, subcontractors, and visitors. The exposure information is analyzed in terms of collective data, dose to individuals, and dose by site. For the purposes of examining trends, data for the past 5 years are included in the analysis.

  9. DOE occupational radiation exposure 2000 report

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2000-12-31

    The U.S. Department of Energy (DOE) Office of Safety and Health publishes the annual DOE Occupational Radiation Exposure Report. This report is intended to be a valuable tool for DOE and DOE contractor managers in managing radiological safety programs and to assist them in prioritizing resources. We appreciate the efforts and contributions from the various stakeholders within and outside DOE in making this report most useful to them. This report includes occupational radiation exposure information for all monitored DOE employees, contractors, subcontractors, and visitors. The exposure information is analyzed in terms of aggregate data, dose to individuals, and dose by site. For the purposes of examining trends, data for the past 5 years are included in the analysis.

  10. DOE occupational radiation exposure 2003 report

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2003-12-31

    The U.S. Department of Energy (DOE) Office of Corporate Performance Assessment (EH-3) publishes the annual DOE Occupational Radiation Exposure Report. This report is intended to be a valuable tool for DOE and DOE contractor managers and workers in managing radiological safety programs and to assist them in prioritizing resources. We appreciate the efforts and contributions from the various stakeholders within and outside DOE to make the report most useful. This report includes occupational radiation exposure information for all monitored DOE employees, contractors, subcontractors, and members of the public. DOE is defined to include the National Nuclear Security Administration sites. The exposure information is analyzed in terms of aggregate data, dose to individuals, and dose by site. For the purposes of examining trends, data for the past 5 years are included in the analysis.

  11. DOE occupational radiation exposure 2002 report

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2002-12-31

    The U.S. Department of Energy (DOE) Office of Corporate Performance Assessment (EH-3) publishes the annual DOE Occupational Radiation Exposure Report. This report is intended to be a valuable tool for DOE and DOE contractor managers and workers in managing radiological safety programs and to assist them in prioritizing resources. We appreciate the efforts and contributions from the various stakeholders within and outside DOE to make the report most useful. This report includes occupational radiation exposure information for all monitored DOE employees, contractors, subcontractors, and members of the public. The exposure information is analyzed in terms of aggregate data, dose to individuals, and dose by site. For the purposes of examining trends, data for the past 5 years are included in the analysis.

  12. Occupational radiation exposure in the Slovak Republic

    International Nuclear Information System (INIS)

    Recently are 2 nuclear power plants in operation in the Slovak republic. Apart from nuclear facilities there are 450 licensed undertakings with monitored workers. The majority of the licensed undertakings are active in health care. In Slovak republic are five dosimetry services performing assessments on personal doses due to external exposure and two dosimetry services are approved to carry out monitoring of internal exposure. Dosemeters used for the monitoring of external individual exposure include: personal whole-body film dosemeters, thermoluminescence dosemeters (TLD) or optically stimulated luminescence dosimeters (OSL) for measurements of beta and gamma radiation; TLD for measurements of neutron radiation and TLD for extremities. The measured operational dose quantities are Hp(10), Hp(3) and Hp(0.07). Approved dosimetry service reports the measured dose data to the employers and to the Central register of occupational doses (CROD). Annually are monitored about 12500 - 16200 active workers. Average effective doses per one monitored worker are presented. (authors)

  13. DOE occupational radiation exposure 1999 report

    Energy Technology Data Exchange (ETDEWEB)

    none,

    1999-12-31

    The U.S. Department of Energy (DOE) Office of Safety and Health publishes the annual DOE Occupational Radiation Exposure Report. This report is intended to be a valuable tool for DOE and DOE contractor managers in managing radiological safety programs and to assist them in prioritizing resources. We appreciate the efforts and contributions from the various stakeholders within and outside DOE and hope we have succeeded in making the report more useful. This report includes occupational radiation exposure information for all monitored DOE employees, contractors, subcontractors, and visitors. The exposure information is analyzed in terms of aggregate data, dose to individuals, and dose by site. For the purposes of examining trends, data for the past 5 years are included in the analysis.

  14. DOE occupational radiation exposure 2004 report

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2004-12-31

    The U.S. Department of Energy (DOE) Office of Corporate Performance Assessment (EH-3) publishes the annual DOE Occupational Radiation Exposure Report. This report is intended to be a valuable tool for DOE and DOE contractor managers and workers in managing radiological safety programs and to assist them in prioritizing resources. We appreciate the efforts and contributions from the various stakeholders within and outside DOE to make the report most useful. This report includes occupational radiation exposure information for all monitored DOE employees, contractors, and subcontractors, as well as members of the public. DOE is defined to include the National Nuclear Security Administration sites. The exposure information is analyzed in terms of aggregate data, dose to individuals, and dose by site. For the purposes of examining trends, data for the past 5 years are included in the analysis.

  15. Radiation exposure in CT-guided interventions

    Energy Technology Data Exchange (ETDEWEB)

    Kloeckner, Roman, E-mail: Roman.Kloeckner@unimedizin-mainz.de [Department of Diagnostic and Interventional Radiology, Johannes Gutenberg-University, Langenbeckstraße 1, 55131 Mainz (Germany); Santos, Daniel Pinto dos; Schneider, Jens [Department of Diagnostic and Interventional Radiology, Johannes Gutenberg-University, Langenbeckstraße 1, 55131 Mainz (Germany); Kara, Levent [Department of Radiology, Inselspital Bern, Freiburgstraße 18, 3010 Bern (Switzerland); Dueber, Christoph; Pitton, Michael B. [Department of Diagnostic and Interventional Radiology, Johannes Gutenberg-University, Langenbeckstraße 1, 55131 Mainz (Germany)

    2013-12-01

    Purpose: To investigate radiation exposure in computed tomography (CT)-guided interventions, to establish reference levels for exposure, and to discuss strategies for dose reduction. Materials and methods: We analyzed 1576 consecutive CT-guided procedures in 1284 patients performed over 4.5 years, including drainage placements; biopsies of different organs; radiofrequency and microwave ablations (RFA/MWA) of liver, bone, and lung tumors; pain blockages, and vertebroplasties. Data were analyzed with respect to scanner settings, overall radiation doses, and individual doses of planning CT series, CT intervention, and control CT series. Results: Eighy-five percent of the total radiation dose was applied during the pre- and post-interventional CT series, leaving only 15% applied by the CT-guided intervention itself. Single slice acquisition was associated with lower doses than continuous CT-fluoroscopy (37 mGy cm vs. 153 mGy cm, p < 0.001). The third quartile of radiation doses varied considerably for different interventions. The highest doses were observed in complex interventions like RFA/MWA of the liver, followed by vertebroplasty and RFA/MWA of the lung. Conclusions: This paper suggests preliminary reference levels for various intervention types and discusses strategies for dose reduction. A multicenter registry of radiation exposure including a broader spectrum of scanners and intervention types is needed to develop definitive reference levels.

  16. Radiation exposure in CT-guided interventions

    International Nuclear Information System (INIS)

    Purpose: To investigate radiation exposure in computed tomography (CT)-guided interventions, to establish reference levels for exposure, and to discuss strategies for dose reduction. Materials and methods: We analyzed 1576 consecutive CT-guided procedures in 1284 patients performed over 4.5 years, including drainage placements; biopsies of different organs; radiofrequency and microwave ablations (RFA/MWA) of liver, bone, and lung tumors; pain blockages, and vertebroplasties. Data were analyzed with respect to scanner settings, overall radiation doses, and individual doses of planning CT series, CT intervention, and control CT series. Results: Eighy-five percent of the total radiation dose was applied during the pre- and post-interventional CT series, leaving only 15% applied by the CT-guided intervention itself. Single slice acquisition was associated with lower doses than continuous CT-fluoroscopy (37 mGy cm vs. 153 mGy cm, p < 0.001). The third quartile of radiation doses varied considerably for different interventions. The highest doses were observed in complex interventions like RFA/MWA of the liver, followed by vertebroplasty and RFA/MWA of the lung. Conclusions: This paper suggests preliminary reference levels for various intervention types and discusses strategies for dose reduction. A multicenter registry of radiation exposure including a broader spectrum of scanners and intervention types is needed to develop definitive reference levels

  17. Radiation exposure mitigation through food

    Energy Technology Data Exchange (ETDEWEB)

    Nishimura, Yoshikazu; Yukawa, Masae; Watanabe, Yoshito; Shiraishi, Kunio; Muramatsu, Yasuyuki; Uchida, Shigeo [National Inst. of Radiological Sciences, Chiba (Japan); Watabe, Teruhisa; Miyazaki, Taeko [National Inst. of Radiological Sciences, Hitachinaka, Ibaraki (Japan). Lab. for Radioecology

    2001-12-01

    {sup 137}CsCl{sub 2} was incorporated into plants (tomyao and broccoli) and these homogenized solutions were administered to rats. The whole-body retention was determined with an Armac counter. The whole body retention patterns of {sup 137}Cs incorporated into the plants were not significantly different from that of the {sup 137}CsCl{sub 2} solution. Chitosan is derived from chitin, which is a cellulose-like biopolymer distributed widely in nature, especially in crustaceans, insects, fungi and yeast. The present study was to investigate whether chitosan can be applied to animal and human bodies in order to reduce the bioavailability of radio-iron and -zinc in food. Chitosan inhibits dietary iron absorption only when rats eat on iron-deficient diet. The effectiveness of phytate (myo-inositol 1,2,3,4,5,6-hexakis dihydrogen phosphate) and chitosan in reducing the bioavailability of radio-zinc depend on the concentration of phytate and chitosan. Recently, the share of imported foods increased ca. 40% of Japanese total food consumption. Radioactivities in imported foods must be checked from the viewpoints of internal radiation for Japanese subjects. Concentrations of {sup 232}Th and {sup 238}U in some imported mineral waters were higher than domestic waters. However, internal doses of portable waters are negligible. Individual foodstuffs in major food groups (fish and shellfish, meats, mushrooms, root vegetables and so on), which contributed to some radionuclide intakes in Japanese, were also analyzed to clarify the critical pathway in Japanese subjects. (author)

  18. Chronic Intake of Japanese Sake Mediates Radiation-Induced Metabolic Alterations in Mouse Liver.

    Directory of Open Access Journals (Sweden)

    Tetsuo Nakajima

    Full Text Available Sake is a traditional Japanese alcoholic beverage that is gaining popularity worldwide. Although sake is reported to have beneficial health effects, it is not known whether chronic sake consumption modulates health risks due to radiation exposure or other factors. Here, the effects of chronic administration of sake on radiation-induced metabolic alterations in the livers of mice were evaluated. Sake (junmai-shu was administered daily to female mice (C3H/He for one month, and the mice were exposed to fractionated doses of X-rays (0.75 Gy/day for the last four days of the sake administration period. For comparative analysis, a group of mice were administered 15% (v/v ethanol in water instead of sake. Metabolites in the liver were analyzed by capillary electrophoresis-time-of-flight mass spectrometry one day following the last exposure to radiation. The metabolite profiles of mice chronically administered sake in combination with radiation showed marked changes in purine, pyrimidine, and glutathione (GSH metabolism, which were only partially altered by radiation or sake administration alone. Notably, the changes in GSH metabolism were not observed in mice treated with radiation following chronic administration of 15% ethanol in water. Changes in several metabolites, including methionine and valine, were induced by radiation alone, but were not detected in the livers of mice who received chronic administration of sake. In addition, the chronic administration of sake increased the level of serum triglycerides, although radiation exposure suppressed this increase. Taken together, the present findings suggest that chronic sake consumption promotes GSH metabolism and anti-oxidative activities in the liver, and thereby may contribute to minimizing the adverse effects associated with radiation.

  19. A translatable predictor of human radiation exposure.

    Directory of Open Access Journals (Sweden)

    Joseph Lucas

    Full Text Available Terrorism using radiological dirty bombs or improvised nuclear devices is recognized as a major threat to both public health and national security. In the event of a radiological or nuclear disaster, rapid and accurate biodosimetry of thousands of potentially affected individuals will be essential for effective medical management to occur. Currently, health care providers lack an accurate, high-throughput biodosimetric assay which is suitable for the triage of large numbers of radiation injury victims. Here, we describe the development of a biodosimetric assay based on the analysis of irradiated mice, ex vivo-irradiated human peripheral blood (PB and humans treated with total body irradiation (TBI. Interestingly, a gene expression profile developed via analysis of murine PB radiation response alone was inaccurate in predicting human radiation injury. In contrast, generation of a gene expression profile which incorporated data from ex vivo irradiated human PB and human TBI patients yielded an 18-gene radiation classifier which was highly accurate at predicting human radiation status and discriminating medically relevant radiation dose levels in human samples. Although the patient population was relatively small, the accuracy of this classifier in discriminating radiation dose levels in human TBI patients was not substantially confounded by gender, diagnosis or prior exposure to chemotherapy. We have further incorporated genes from this human radiation signature into a rapid and high-throughput chemical ligation-dependent probe amplification assay (CLPA which was able to discriminate radiation dose levels in a pilot study of ex vivo irradiated human blood and samples from human TBI patients. Our results illustrate the potential for translation of a human genetic signature for the diagnosis of human radiation exposure and suggest the basis for further testing of CLPA as a candidate biodosimetric assay.

  20. Occupational radiation exposures in Canada - 1979

    International Nuclear Information System (INIS)

    This report is the second in a series of annual reports on Occupational Radiation Exposures in Canada. The data is derived from the Radiation Protection Bureau's National Dose Registry which includes dose records for radiation workers in Canada. The report presents average yearly doses by region and occupational category, dose distributions, and variation of average doses with time. Statistical data concerning investigations of high exposures are included and individual cases are briefly summarized where the maximum permissible dose is exceeded. The 1979 data indicate that the gradually decreasing trend of the last two decades may be changing. In a number of areas the overall average doses and the averages for some job categories have increased over the corresponding values for 1977 and 1978

  1. Occupational radiation exposures in Canada, 1981

    International Nuclear Information System (INIS)

    This report is the fourth in a series of annual reports on Occupational Radiation Exposures in Canada. The data is derived from the Radiation Protection Bureau's National Dose Registry which includes those records for radiation workers. The report presents average yearly doses by region and occupational category, dose distributions, and variation of average doses with time. Statistical data concerning investigations of high exposures reported by the National Dosimetry Services are included and individual cases are briefly summarized where the maximum permissible dose is exceeded. The decrease in the overall average doses established over the last 20 years appears to have resumed after an interruption during 1979 to 1980. A brief summary of extremity dose data is also included

  2. Risk of cardiovascular disease following radiation exposure

    International Nuclear Information System (INIS)

    Excess radiation-induced cardiac mortalities have been reported among radiotherapy patients. Many case reports describe the occurrence of atherosclerosis following radiotherapy for Hodgkin's disease and breast cancer. Some case reports describe the cerebral infarction following radiotherapy to neck region, and of peripheral vascular disease of the lower extremities following radiotherapy to the pelvic region. The association of atomic bomb radiation and cardiovascular disease has been examined recently by incidence studies and prevalence studies of various endpoints of atherosclerosis; all endpoints indicated an increase of cardiovascular disease in the exposed group. It is almost certain that the cardiovascular disease is higher among atomic bomb survivors. However, since a heavy exposure of 10-40 Gy is delivered in radiotherapy and the bomb survivors were exposed to radiation at high dose and dose-rate, the question is whether the results can be extrapolated to individuals exposed to lower levels of radiation. Some recent epidemiological studies on occupationally exposed workers and population living near Chernobyl have provided the evidence for cardiovascular disease being a significant late effect at relatively low doses of radiation. However, the issue of non-cancer mortality from radiation is complicated by lack of adequate information on doses, and many other confounding factors (e.g., smoking habits or socio-economic status). This presentation will evaluate possible radiobiological mechanisms for radiation-induced cardiovascular disease, and will address its relevance to radiation protection management at low doses and what the impact might be on future radiation risk assessments. (authors)

  3. Effects of low-level exposure to ionizing radiation: current concepts and concerns for veterinary workers

    International Nuclear Information System (INIS)

    The issue of biological effects caused by low-level exposure to ionizing radiation (0.1Sv/yr or 10 rem) is a concern of veterinary radiologists, clinicians and radiotherapists. Cellular damage from ionizing radiation is mediated by injury to DNA, some of which can be repaired. The most important harmful effects attributed to low-level exposure are carcinogenesis and mutation. Ionizing radiation may also cause embryonic and fetal damage, life span shortening and cataractogenesis. The estimated excess risk of mortality for all human cancers is 0.8% (800 deaths per 100,000) per 0.10 Sv of acute exposure; at low dose-rates, risk is presumed to be less. Ionizing radiation increases the frequency of spontaneous genic and chromosomal mutations in man and animals. Studies of atomic bomb survivors imply that at least 1 Sv would be needed to double the spontaneous mutation rate for acute exposure to low-LET radiation. However, the doubling dose for chronic, low-level exposure may be 4 Sv or more. The human embryo and fetus are sensitive to excessive doses of ionizing radiation, with mental retardation the main concern in the low dose range. Paradoxically, there is scientific evidence that in some instances, chronic low-level exposure to ionizing radiation causes a beneficial or hormonic effect. For veterinary workers, occupational exposures appear to be well below the maximum permissible dose limit and the risk or probability of harmful effects is low if stringent radiation safety practices are maintained

  4. Thyroid cancer post exposure to radiation

    International Nuclear Information System (INIS)

    Reviewed and discussed is the radiation-induced thyroid cancer (TC) from aspects of epidemiology along with the medical and accidental exposure, and of gene level. Medical external exposure to the thyroid occurs by radiation therapy of head and neck diseases and the internal exposure, by radioiodine administration for treatment of Basedow disease and postoperative ablation of TC. Excessive relative risk of TC in A-bomb survivors is 1.15, statistically significant, is 10 times higher in 40 y. TC is generally rare (the incidence, 1 per 100thousands/y), but after the Chernobyl Accident, the incidence is increased to 10-100 times. The incidence of pediatric TC is found to reach the peak at 10 years after the Accident and has decreased to the normal level at present. Instead, TC is now at a peak incidence in adolescents and young adults (15-24 years old) who were exposed at their childhood: risk is found the highest in infants of the age 0-4 y. The exposure was mainly internal by radioiodine through breast milk and food. Histopathological tissue type of TC is rather different from that in Japan, suggesting the low iodine content in the area around Chernobyl. Risk of TC is obscure for the fetal exposure to radioiodine. Chernobyl Tissue Bank has a stock of 3,800 TC specimens. At present, gene mutation specific in radiation-induced TC alone is not found. Although the health risk of exposure to <100 mSv is said to be hardly proven and the internal exposure dose level by the Fukushima Nuclear Power Plant Accident is said to be much lower than that by Chernobyl Accident, the health management of Fukushima residents should be followed up for long term. (T.T.)

  5. Dissimilar genome response to acute and chronic low-dose radiation in male and female mice

    International Nuclear Information System (INIS)

    The long-term genetic consequences of chronic exposure to low-dose irradiation constitutes a major concern to the general public and research community, especially as chronic radiation has recently been proven to be much more mutagenic and carcinogenic than previously thought. Here we report the results of the first ever comparison of the effects of acute and chronic whole body low-dose radiation exposure on global gene expression. We found a substantial difference between males and females in the expression of genes involved in signaling, growth control, transcription and other pathways upon acute and chronic radiation exposure. Specifically, we found sex differences in the expression of genes coding for G protein-coupled receptors and nuclear receptors. We also found different induction of PKCδ, PKCβ and PKCμ, members of PKC signaling pathway as well as in TGF and WNT signaling in males and females. Very pronounced difference, that was confirmed on the level of protein, was observed in the expression of WNT5A that plays an important role in carcinogenesis and muscle regeneration. WNT5A expression was significantly elevated only in chronically exposed females. We also provide the first evidence of the effect of ionizing radiation on the estrogen receptor in females. Repetitive irradiation of muscle tissue has been linked to development of rhabdomyosarcoma (RMS), which, enigmatically, occurs more frequently in males. Our data may be used to study possible mechanisms of RMS development upon chronic radiation exposure. They may provide some clues about the molecular background of the sex differences of RMS occurrence and may in the future lead to the discovery of new biomarkers for RMS predisposition in the irradiated tissue. Overall, differences in male and female responses to acute and chronic low-dose radiation obtained by this study were more drastic than we could have predicted. If confirmed in other experimental systems, these findings could potentially lead

  6. ESR radiation dose evaluation on radiation exposure accident in England

    International Nuclear Information System (INIS)

    A technician of nondestructive inspection in England died because of radiation injury even though his exposure record with film badge indicated only 104 mSv of the lifelong exposure dose. After the request of the National Radiation Protection Board of Great Britain, the author conducted measurement of the exposure dose with ESR dosimetry. ESR spectra were measured on tooth enamel and bones of the finger and the upper arm taken from the dead technician. The exposure dose is obtained from the enhancement of the ESR signal intensity of CO2- after international irradiation. 14 and 12 Gy for tooth enamel, 7.2 and 4.2 Gy for the bones of the finger and the upper arm respectively. The bone samples may show smaller dose due to metabolism in the body. The technician is assumed to be exposed about 10 mSv at the fingers and the arms for each time on the inspection of pipings for more than 10 years. He used to wear the film badge on his waist. The author stresses the importance of preservation of extracted tooth as a exposure record for radiation workers. (T.H.)

  7. Radiation exposure of the UK population

    International Nuclear Information System (INIS)

    Man is continuously exposed to radiation from many sources, both natural and man-made. The man-made sources include medical irradiation, exposure from radioactive waste disposal, fallout from nuclear weapons tests and various 'miscellaneous sources' which include consumer products. The National Radiological Protection Board (NRPB) keeps these contributions to the radiation exposure of the population under continuous review and publishes reports on the subject periodically. This is the second such report and contains considerably more information than the first published in 1974. The balance of the report reflects the availability of data and the advice given in the sixth report of the Royal Commission on Environmental Pollution. The conclusions are: (a) that the major contribution to the dose to the population is from natural background radiation; (b) that the largest man-made contribution is from medical uses of radiation; (c) that the largest contribution from environmental contamination is still from the residual effects of fallout from nuclear weapons testing; (d) that occupational exposure and irradiation from miscellaneous sources, considered as contributions to the per caput dose to the population, are the next largest components; (e) that radioactive waste disposal is the smallest contributor to the per caput dose to the population. It was also felt useful to review the past trends in the doses resulting from the various sources and the authors have attempted to make some tentative predictions of doses up to the year 2000. (author)

  8. Plants as warning signal for exposure to low dose radiation

    International Nuclear Information System (INIS)

    The stamen-hair system of Tradescantia for flower colour has proven to be one of the most suitable materials to study the frequency of mutations induced by low doses of various ionizing radiations and chemical mutagens. The system has also been used successfully for detecting mutagenic synergisms among chemical mutagens and ionizing radiations as well as for studying the variations of spontaneous mutation frequency. In this study of radiobiology, the main objective is to observe somatic mutation (occurrence of pink cells from blue cells) induced on stamen hairs of five Tradescantia sp. available in Malaysia after exposure to low doses of chronic gamma irradiation using Gamma Green House. Pink cells appeared only on Tradescantia Pallida Purpurea stamen hairs after 13 days of exposure to irradiation with different doses of gamma rays. The highest number of stamens with pink cells was recorded from flowers irradiated with the highest dose of 6.37 Gy with 0.07 Gy/ h of dose rate. The lowest number of stamens with pink cells was recorded with an average of 0.57, irradiated with the lowest dose of 0.91 Gy with 0.01 Gy/ h of dose rate. There were no pink cells observed on Tradescantia Spathaceae Discolor after exposure to different doses of gamma rays. Similar negative results were observed for the control experiments. The principal cells in this assay are the mitotic stamen hair cells developing in the young flower buds. After exposure to radiation, the heterozygous dominant blue character of the stamen hair cell is prevented, resulting in the appearance of the recessive pink color. Furthermore, no pink cell appears on all species of Tradescantia spathaceae after irradiated with different doses of gamma rays. The sensitivity of the Tradescantia has been used widely and has demonstrated the relation between radiation dose and frequency of mutation observed at low doses which can contribute to the effects of low doses and their consequences for human health. This system

  9. Radiation exposure during air and ground transportation

    International Nuclear Information System (INIS)

    The results of a one year study program of radiation exposure experienced on both domestic and international flights of the China Airline and the Far East Airline in the Pacific, Southeast Asia and Taiwan areas and on trains and buses on Taiwan island are reported. CaSO4:Dy thermoluminescent dosimeters were used. It has been shown that transit exposures may amount to 10 times that on the ground with an altitude varying from 3,050 to 12,200 m. (U.K.)

  10. Personnel radiation exposure in HTGR plants

    International Nuclear Information System (INIS)

    Occupational radiation exposures in high-temperature gas-cooled reactor (HTGR) plants were assessed. The expected rate of dose accumulations for a large HTGR steam cycle unit is 0.07 man-rem/MW(e)y, while the design basis is 0.17 man-rem/MW(e)y. The comparable figure for actual light water reactor experience is 1.3 man-rem/MW(e)y. The favorable HTGR occupational exposure is supported by results from the Peach Bottom Unit No. 1 HTGR and Fort St. Vrain HTGR plants and by operating experience at British gas-cooled reactor stations

  11. Justification of novel practices involving radiation exposure

    International Nuclear Information System (INIS)

    The concept of 'justification' of practices has been one of the three basic principles of radiation protection for many decades. The principle is simple in essence - that any practice involving radiation exposure should do more good than harm. There is no doubt that the many uses of radiation in the medical field and in industry generally satisfy this principle, yielding benefits that could not be achieved using other techniques; examples include CT scanning and industrial radiography. However, even in the early period after the introduction of the justification principle, there were practices for which the decision on justification was not clear and for which different decisions were made by the authorities in different countries. Many of these involved consumer products such as luminous clocks and watches, telephone dials, smoke detectors, lightning preventers and gas mantles. In most cases, these practices were relatively small scale and did not involve large exposures of either individual workers or members of the public. Decisions on justification were therefore often made by the regulator without extensive national debate. Over recent years, several practices have been proposed and undertaken that involve exposure to radiation for purposes that were generally not envisaged when the current system of radiation protection was created. Some of these practices were reviewed during a recent symposium held in Dublin, Ireland and involve, for example, the x-raying of people for theft detection purposes, for detection of weapons or contraband, for the prediction of physical development of young athletes or dancers, for age determination, for insurance purposes and in cases of suspected child abuse. It is particularly in the context of such novel practices that the need has emerged for clearer international guidance on the application of the justification principle. This paper reviews recent activities of the IAEA with respect to these issues, including the

  12. Low-level chronic exposure to tritium: An improved basis for hazard evaluation

    International Nuclear Information System (INIS)

    The possibility that significant biological effects may result from chronic low-level exposure to 3HOH is the main health and environmental concern regarding tritium from nuclear energy operations. Direct data for such exposure are, however, largely still unavailable. Information on chronic irradiation at low levels derives mostly from γ-ray studies, so extrapolations are necesary for tritium. But controversy exists on tritium's relative biological effectiveness (RBE) compared to γ radiation and on the related quality factor (Q) used for radiation protection (recently adjusted downward from 1.7 to 1). A firmer basis for extrapolation is needed. The author has obtained quantitative data for low-level 3HOH and 60Co γ-ray exposures in the intact mammal. Developing mice were exposed to various doses over 33 days; surviving oocytes were then counted in ovaries and compared with controls, providing dose-response curves for both radiations. By comparing these curves, RBE values were determined. The RBE was found to vary inversely with dose, in accord with the theory of dual radiation action. At γ-ray doses of 50 rads, the RBE was 1.6. It increased at lower doses, reaching a value of approximately 3. With short exposures, the RBE was lower, due possibly to differences in microdistribution of 3H. These results demonstrate that conclusions from both high-dose and short-term experiments are likely to underestimate the effects of low-level chronic exposure to 3HOH. Measurement of the systematic variation of tritium's RBE with dose and recognition of the effect of exposure duration provide a more secure basis for hazard evaluation. (author)

  13. Impact of chronic and acute pesticide exposures on periphyton communities

    International Nuclear Information System (INIS)

    Aquatic ecosystems face variable exposure to pesticides, especially during floodings which are associated with short bursts of high contaminant concentrations that influence biological systems. A study was undertaken to highlight the impact of the herbicide diuron applied in mixture with the fungicide tebuconazole on natural periphyton during flooding events. Periphyton were grown in two series of two lotic outdoor mesocosms: one series was non-contaminated while the other was exposed to chronic contamination. After 4 weeks, one channel of each series was exposed to three successive pulses, with each pulse followed by one week of recovery. Impacts on periphyton were assessed by using Denaturing Gel Gradient Electrophoresis to characterize eukaryotic community structure. At a functional scale, photosynthetic efficiency was quantified during each pulse, and the induced tolerance to diuron was estimated by performing short-term inhibition tests based on photosynthetic efficiency. Moreover, pesticide concentrations in the water column and periphyton matrix were measured. Diuron was adsorbed in the periphyton during each pulse and desorbed 13 h after pulse end. The different pulses affected the eukaryotic community structures of the control biofilms, but not of the chronically exposed ones. During the first pulse, photosynthetic efficiency was correlated with pesticide concentration in the water phase, and there was no difference between periphyton from chronically contaminated channels and control channels. However, during the second and third pulses, the photosynthetic efficiency of periphyton chronically exposed to pesticides appeared to be less impacted by the acute pulsed exposure of pesticide. These changes were consistent with the acquisition of induced tolerance to diuron since only after the third pulse that periphyton from chronic channel became tolerant to diuron. Our experimental study indicates that the effects of pulsed acute exposures to pesticides on

  14. Radiation exposure and radiation risk of the population

    International Nuclear Information System (INIS)

    The major scientifically founded results concerning the assessment of the radiation exposure and the analysis and evaluation of the radiationhazards for the population, particularly in the range of low doses, are presented. As to the risk analysis special attention is paid to the rays with low ionization density (X-, γ-, β- and electronrays). Contents: 1) Detailed survey of the results and conclusions; 2) Data on the radiation load of the population; 3) Results to epidemiological questioning on the risk of cancer; 4) Genetical radiation hazards of the population. For quantification purposes of the risk of cancer by γ-radiation the observations with the a-bomb survivors in Japan are taken as a basis, as the available dosimetrical data have to be revised. Appendices: 1) German translation of the UNSCEAR-Report (1977); 2) BEIR-Report (1980); 3) Comments from the SSK on the comparability of the risks of natural-artificial radiation exposure; 4) Comments from the SSK on the importance of synergistical influences for the radiation protection (23.9.1977). (HP)

  15. Population exposure to ionising radiation in India

    International Nuclear Information System (INIS)

    Estimates of exposure from various radiation sources to Indian population are given. The per caput dose from all the identifiable sources, both natural and man-made is estimated to be 2490 μSv per year to the present population of India. 97.9% of this dose is contributed by natural sources which include cosmic and terrestrial radiations, 1.93% by medical sources used for diagnostic and treatment purpose, 0.3% by exposures due to activities related nuclear fuel cycle, nuclear tests and nuclear accidents, and 0.07% by miscellaneous sources such as industrial applications, consumer products, research activities, air travel etc. The monograph is written for the use of the common man. (M.G.B.). 25 refs., 7 tabs., 7 figs

  16. Wireless Phones Electromagnetic Field Radiation Exposure Assessment

    Directory of Open Access Journals (Sweden)

    A. D. Usman

    2009-01-01

    Full Text Available Problem statement: Inadequate knowledge of electromagnetic field emitted by mobile phones and increased usage at close proximity, created a lot of skepticism and speculations among end users on its safety or otherwise. Approach: In this study, near field electromagnetic field radiation measurements were conducted on different brand of mobile phones in active mode using a tri-axis isotropic probe and electric field meter. Results: The highest electromagnetic field exposure was recorded when the mobile phones are at outgoing call mode and backing the probe, which is higher in comparison to ICNIRP guidelines for exposure to general public. Conclusion: According to this finding, some mobile phones electromagnetic field radiation were found to be lower than the ICNIRP guidelines while some were far above the guidelines. Electromagnetic field intensity however, depends on the mode of operation and proximity of the mobile phones to the end user; hence it is safer to use mobile phones at SMS mode.

  17. Modeling Impaired Hippocampal Neurogenesis after Radiation Exposure.

    Science.gov (United States)

    Cacao, Eliedonna; Cucinotta, Francis A

    2016-03-01

    Radiation impairment of neurogenesis in the hippocampal dentate gyrus is one of several factors associated with cognitive detriments after treatment of brain cancers in children and adults with radiation therapy. Mouse models have been used to study radiation-induced changes in neurogenesis, however the models are limited in the number of doses, dose fractions, age and time after exposure conditions that have been studied. The purpose of this study is to develop a novel predictive mathematical model of radiation-induced changes to neurogenesis using a system of nonlinear ordinary differential equations (ODEs) to represent the time, age and dose-dependent changes to several cell populations participating in neurogenesis as reported in mouse experiments exposed to low-LET radiation. We considered four compartments to model hippocampal neurogenesis and, consequently, the effects of radiation treatment in altering neurogenesis: (1) neural stem cells (NSCs), (2) neuronal progenitor cells or neuroblasts (NB), (3) immature neurons (ImN) and (4) glioblasts (GB). Because neurogenesis is decreasing with increasing mouse age, a description of the age-related dynamics of hippocampal neurogenesis is considered in the model, which is shown to be an important factor in comparisons to experimental data. A key feature of the model is the description of negative feedback regulation on early and late neuronal proliferation after radiation exposure. The model is augmented with parametric descriptions of the dose and time after irradiation dependences of activation of microglial cells and a possible shift of NSC proliferation from neurogenesis to gliogenesis reported at higher doses (∼10 Gy). Predictions for dose-fractionation regimes and for different mouse ages, and prospects for future work are then discussed. PMID:26943452

  18. CHRONIC DEVELOPMENTAL LEAD EXPOSURE REDUCES NEUROGENESIS IN ADULT HIPPOCAMPUS.

    Science.gov (United States)

    CHRONIC DEVELOPMENTAL LEAD EXPOSURE REDUCES NEUROGENESIS IN ADULT HIPPOCAMPUS. ME Gilbert1, ME Kelly2, S. Salant3, T Shafer1, J Goodman3 1Neurotoxicology Div, US EPA, RTP, NC, 27711, 2Children's Hospital, Philadelphia, PA, 19104, 3Helen Hayes Hospital, Haverstraw, NY, 10993. ...

  19. Microwave radiation - Biological effects and exposure standards

    Energy Technology Data Exchange (ETDEWEB)

    Lindsay, I.R.

    1980-06-01

    The thermal and nonthermal effects of exposure to microwave radiation are discussed and current standards for microwave exposure are examined in light of the proposed use of microwave power transmission from solar power satellites. Effects considered include cataractogenesis at levels above 100 mW/sq cm, and possible reversible disturbances such as headaches, sleeplessness, irritability, fatigue, memory loss, cardiovascular changes and circadian rhythm disturbances at levels less than 10 mW/sq cm. It is pointed out that while the United States and western Europe have adopted exposure standards of 10 mW/sq cm, those adopted in other countries are up to three orders of magnitude more restrictive, as they are based on different principles applied in determining safe limits. Various aspects of the biological effects of microwave transmissions from space are considered in the areas of the protection of personnel working in the vicinity of the rectenna, interactions of the transmitted radiation with cardiac pacemakers, and effects on birds. It is concluded that thresholds for biological effects from short-term microwave radiation are well above the maximal power density of 1 mW/sq cm projected at or beyond the area of exclusion of a rectenna.

  20. Radiation exposure monitoring in civil aircraft

    Science.gov (United States)

    Schrewe, Ulrich J.

    1999-02-01

    Based on the 1990 Recommendation of the ICRP (ICRP Publication 60, Pergamon Press, Oxford, 1991) a European Directive [Official J. Eur. Communities 19 (1996) L159, 1-114] commits the European Union (EU) member states to revise their national radiation protection laws by the year 2000 such that the exposure of aircrews to the increased cosmic radiation prevailing at aviation flight altitudes will be treated as occupational risks. A consequence will be that employers must assess the aircrew exposure. The ACREM (Air Crew Radiation Exposure Monitoring) research project intends to investigate practically methods for aircraft dose equivalent determination. The in-flight measurements were carried out on cargo aircraft. Field calibrations were performed using Tissue-Equivalent Proportional Counters (TEPC) as the reference instrument. Various monitors were used to investigate the spatial doserate distribution. The measured data were collated according to the different altitudes and geomagnetic latitudes. The results obtained from various in-flight measurements are reported and a concept for a future routine dose assessment for aircrew is proposed.

  1. Radiation exposure monitoring in civil aircraft

    International Nuclear Information System (INIS)

    Based on the 1990 Recommendation of the ICRP (ICRP Publication 60, Pergamon Press, Oxford, 1991) a European Directive [Official J. Eur. Communities 19 (1996) L159, 1-114] commits the European Union (EU) member states to revise their national radiation protection laws by the year 2000 such that the exposure of aircrews to the increased cosmic radiation prevailing at aviation flight altitudes will be treated as occupational risks. A consequence will be that employers must assess the aircrew exposure. The ACREM (Air Crew Radiation Exposure Monitoring) research project intends to investigate practically methods for aircraft dose equivalent determination. The in-flight measurements were carried out on cargo aircraft. Field calibrations were performed using Tissue-Equivalent Proportional Counters (TEPC) as the reference instrument. Various monitors were used to investigate the spatial doserate distribution. The measured data were collated according to the different altitudes and geomagnetic latitudes. The results obtained from various in-flight measurements are reported and a concept for a future routine dose assessment for aircrew is proposed

  2. The natural sources of ionizing radiation exposure

    International Nuclear Information System (INIS)

    Natural sources of ionizing radiation include external sources (cosmic rays, natural radionuclides present in the crust of the earth and in building materials) and internal sources (naturally occuring radionuclides in the human body, especially the potassium 40 and radon short lived decay products). The principal ways of human exposure to theses different components in ''normal'' areas are reviewed; some examples of the variability of exposure with respect to different regions of the world or the habits of life are given. Actual estimations of the doses delivered to the organs are presented; for the main contributors to population exposure, the conversion into effective dose equivalent has been made for allowing a better evaluation of their respective importance

  3. Occupational radiation exposure. Twelfth annual report, 1979

    International Nuclear Information System (INIS)

    This report summarizes the occupational exposure data that is maintained in the US Nuclear Regulatory Commission's Radiation Exposure Information and Reports System (REIRS). This report is usually published on an annual basis and is available at all NRC public document rooms. The bulk of the information contained in the report was extracted from annual statistical reports submitted by all NRC licensees subject to the reporting requirements of 10 CFR 20.407. Four categories of licensees - operating nuclear power reactors, fuel fabricators and reprocessors, industrial radiographers, and manufacturers and distributors of specified quantities of byproduct materials - also submit personal identification and exposure information for terminating employees pursuant to 10 CFR 20.408, and some analysis of this data is also presented in this report

  4. Strategies for protection against exposure to ionizing radiation

    International Nuclear Information System (INIS)

    Radiations are known to be mutagenic, carcinogenic and cyto-lethal depending on the total dose, dose rate, quality of radiation and many other factors related to the person exposed. Therefore strategies for protection against exposure to ionizing radiations have to be accordingly planned. Radioprotection, though remains prophylactic in principle, includes mitigating and therapeutic modalities also. Initially, the central theme of biological radioprotection has been to protect against radiation-induced lethality and to optimize radiotherapy of tumours; the emphasis has now extended to cover many more situations of planned and unplanned nature. The central dogma of radioprotection work has been antioxidant action, which is relevant indeed against low LET radiation. The increasing understanding of the mechanism of radiation damage, however, permitted the advent of newer agents of both synthetic and natural origin. Sulfhydryl compounds like cysteamine, AET, Amifostine and endogenous molecules like GSH, SOD etc have been very important agents. Molecules like cytokines, immunomodulators, anti-inflammatory agents, angiotensin converting enzymes, metallo-elements and metallothionins, DNA ligands and Calcium antagonists have also been investigated recently. Unfortunately, no single agent could yield desired results especially due to toxicity at their radioprotective concentration. This led to the emergence of combinational modality where two or more agents working with different mechanisms could synergistically complement radioprotective action.. Recently, herbal extracts and dietary agents, which are the natural combinations of a large number of compounds that have important attributes to counter the damaging effects of ionizing radiations, have gained world-wide interest.. These agents have been found to be less toxic. Decorporation of radionuclei and protection against low dose chronic exposures like space flights and long haul inter-continental flights need to be

  5. Unjustified prenatal radiation exposure in medical applications

    International Nuclear Information System (INIS)

    The exposure to the radiation ionising of pregnant women, frequently constitutes motive of preoccupation for the expectant mother and the medical professionals taken the responsibility with its attention. The protection of the embryo-fetus against the ionising radiation is of singular importance due to its special vulnerability to this agent. On the other hand the diagnosis or treatment with radiations ionising beneficial for the expectant mother, are only indirectly for the embryo-fetus that is exposed to a hazard without perceiving anything. The present paper presents the experience obtained in the clinical and dosimetric evaluation from twenty-one pregnant patients subjected to diverse radiodiagnostic procedures or nuclear medicine during the years 1999-2000. The obtained results evidence that 24% of the patients was subjected to procedures of nuclear medicine with diagnostic purposes. While the period of pregnancy of the patients ranged between 4 and 12 weeks, it could be concluded that in all the cases the doses received by the patients in the whole body did not exceed 2 mSv. When conjugating the period of pregnancy of the patients with the doses received, there is no evidence of significant risk for the embryo-fetus. Paradoxically the physicians of assistance suggested to their patients in all the cases to carry out the interruption of the pregnancy, demonstrating with this decision ignorance on the biological effects of the ionizing radiations during the prenatal exposures. (author)

  6. Lung cancer following exposure to ionizing radiation

    International Nuclear Information System (INIS)

    A case-control study of lung cancer was conducted in Hiroshima and Nagasaki, Japan, to evaluate risk factors for this common neoplasm, with special attention given to assessing the potentially interactive roles of cigarette smoking and atomic radiation. The investigation involved interviews with 428 patients with primary lung cancer and 957 matched controls, or with their next of kin in the event of death or disability. The interview information was supplemented by data on atomic bomb radiation exposure for each individual and on smoking and other factors from prior surveys of subsets of the population studied. Separate effects of smoking and high dose (greater than 100 rad) radiation were found, with the two exposures combining to affect lung cancer risk in an approximate additive fashion. The additive rather than multiplicative model was favored whether the smoking variable was dichotomized (ever vs. never smoked), categorized into one of several groups based on amount smoked, or treated as a discrete variable. The findings are contrasted with those for Colorado uranium miners and other cohorts occupationally exposed to radon and its daughter products, where smoking and radiation have been reported to combine multiplicatively to enhance lung cancer risk

  7. The global assessment of medical radiation exposures

    International Nuclear Information System (INIS)

    World Health Organization (WHO) is the United Nations specialized agency which acts as a coordinating authority on international public health. It was established in 1948. It has 147 Country Offices, 6 Regional Offices and 193 Member States Ministries of Health Its headquarters is in Geneva. The World Health Assembly (WHA) requested WHO to study the optimum use of ionizing radiation in medicine and the risks to health of excessive or improper use. (WHA, 1971) International Basic Safety Standards BSS) The (BSS) mark the culmination of efforts towards global harmonization of radiation safety requirements. However, the involvement of the health sector in the BSS implementation is still weak and scant. There is a need to mobilize the health sector towards safer and effective use of radiation in medicine. Radiation in Health Care The use of radiation in health care is by far the largest contributor to the exposure of the general population from artificial sources. Annually worldwide there are 3,600 million X-ray exams (> 300 million in children), 37 million nuclear medicine procedures and 7.5 million radiation oncology treatments [UNSCEAR Report 2008]. WHO Global Initiative on Radiation Safety in Health Care Settings Was launched in December 2008 It involved the following:- There was involvement of international organizations and professionals bodies, national health and radiation protection authorities, etc. Its aim is to improve the protection of patients and health care workers through better implementation of the BSS. It complements the International Action Plan for Radiological Protection of Patients established by the IAEA 7 UNSCEAR's medical exposure survey Objectives of UNSCEAR's survey were to facilitate evaluation of: - Global estimates of frequency and levels of exposures, with break-downs by medical procedure, age, sex, health care level, and country; - Trends in practice (including those relatively fast-changing); with supporting contextual

  8. Occupational radiation exposures in Canada - 1978

    International Nuclear Information System (INIS)

    This 1978 report is the first in a series of annual reports on occupational radiation exposures in Canada. The data are derived from the Radiation Protection Bureau's National Dose Registry which includes dose records for radiation workers in Canada. The report presents average yearly doses by region and occupational category, dose distributions, and variation of average doses with time. Statistical data concerning investigations of overexposures are included and individual cases are briefly summarized where the maximum permissible dose is exceeded. The 1978 data indicate that the gradually decreasing trend of the last two decades may have changed. In a number of areas the overall average doses and the averages for some job categories have increasd over the corresponding values for 1977

  9. Monitoring and control of occupational radiation exposure in Switzerland

    International Nuclear Information System (INIS)

    Occupational exposure is the most prominent example for the prolonged exposure to low level ionizing radiation characterized by low doses and dose rates. In this paper the occupational exposure in Switzerland is presented and the regulatory control of this exposure in the framework of the new radiation protection regulations is discussed. (author)

  10. Radiation protection of aviation personnel at exposure by cosmic radiation

    International Nuclear Information System (INIS)

    For determination of radiation dose of aviation personnel we used the software EPCARD (European Program Package for the Calculation of Aviation Route Doses) developed by National Research Center for Environmental Health - Institute of Radiation Protection (Neuherberg, Germany) and the software CARI 6, developed by the FAA's Civil Aerospace Medical Institute (USA). Both codes are accomplished by the Joint Aviation Authorities. Experimental measurement and estimation of radiation doses of aviation personnel at exposure by cosmic radiation were realised in the period of lowered solar activity. All-year effective dose of pilots, which worked off at least 11 months exceeds the value 1 mSv in 2007. The mean all-year effective dose of member of aviation personnel at exposure by cosmic radiation is 2.5 mSv and maximal all-year effective dose, which we measured in 2007 was 4 mSv. We assumed that in the period of increased solar activity the all-year effective doses may by higher

  11. Ionizing Radiation Environments and Exposure Risks

    Science.gov (United States)

    Kim, M. H. Y.

    2015-12-01

    Space radiation environments for historically large solar particle events (SPE) and galactic cosmic rays (GCR) are simulated to characterize exposures to radio-sensitive organs for missions to low-Earth orbit (LEO), moon, near-Earth asteroid, and Mars. Primary and secondary particles for SPE and GCR are transported through the respective atmospheres of Earth or Mars, space vehicle, and astronaut's body tissues using NASA's HZETRN/QMSFRG computer code. Space radiation protection methods, which are derived largely from ground-based methods recommended by the National Council on Radiation Protection and Measurements (NCRP) or International Commission on Radiological Protections (ICRP), are built on the principles of risk justification, limitation, and ALARA (as low as reasonably achievable). However, because of the large uncertainties in high charge and energy (HZE) particle radiobiology and the small population of space crews, NASA develops distinct methods to implement a space radiation protection program. For the fatal cancer risks, which have been considered the dominant risk for GCR, the NASA Space Cancer Risk (NSCR) model has been developed from recommendations by NCRP; and undergone external review by the National Research Council (NRC), NCRP, and through peer-review publications. The NSCR model uses GCR environmental models, particle transport codes describing the GCR modification by atomic and nuclear interactions in atmospheric shielding coupled with spacecraft and tissue shielding, and NASA-defined quality factors for solid cancer and leukemia risk estimates for HZE particles. By implementing the NSCR model, the exposure risks from various heliospheric conditions are assessed for the radiation environments for various-class mission types to understand architectures and strategies of human exploration missions and ultimately to contribute to the optimization of radiation safety and well-being of space crewmembers participating in long-term space missions.

  12. Radiation exposure in medicare-occupational and medical exposure

    International Nuclear Information System (INIS)

    Recent cases of the occupational and medical exposures are discussed in relation to the justification of practice, optimization of protection and effort to reduce the dose. Instances of the occupational exposure in doctors and nurses like 26.5 mSv/15 mo and 53.9 mSv/y, and of skin cancer were reported in newspapers of 1999-2004, which might have had been prevented by their self evaluation of daily and monthly exposed dose. For reasonably lowering the occupational dose and number of exposed stuff in the present law, the prior radiation protection measures are to be taken in consideration of social/economical factors to conduct beneficial radiation medicare without restriction of practice under safest conditions, protecting personal determinative hazard and preventing stochastic effect. Medical stuff must be equipped with personal dosimeter. Further, recent media also commented such cases as unwished abortions after careless X-CT of pregnant women, and risk of increased cancer prevalence (3.2% in Japan) due to medical exposure, etc (200-2010). The prevalence is calculated on the linear non-threshold (LNT) hypothesis and is probably overestimated, possibly causing patient's fear. There has been a history of proposal by IAEA (1996) of the guidance levels of the ordinary roentgenography and in vivo nuclear medical test, and introduction of the concept of dose constraint by ICRP (Pub. 60). The incident dose rate to the patient under fluoroscopy defined by Japan Medical Service Law (2001) is, as an air-kerma rate, 15,600 residents for their contamination as well as remains, and measured the ambient dose rate of cities nearby. (T.T.)

  13. Solar radiation and the ultraviolet radiation exposure standard

    International Nuclear Information System (INIS)

    Partly as a result of increased concern over the possible depletion of stratospheric ozone and concomitant biological effects such as an increased incidence of skin cancer, ARL is extending the scope of its solar ultraviolet radiation (UVR) measurement programme. The results obtained thus far will be presented and their implication for the outdoor worker will be discussed in terms of the Australian occupational UVR exposure standard and the need to change existing work practises and personal protection

  14. DOE 2012 Occupational Radiation Exposure October 2013

    Energy Technology Data Exchange (ETDEWEB)

    None

    2012-02-02

    The U.S. Department of Energy (DOE) Office of Analysis within the Office of Health, Safety and Security (HSS) publishes the annual DOE Occupational Radiation Exposure Report to provide an overview of the status of radiation protection practices at DOE (including the National Nuclear Security Administration [NNSA]). The DOE 2012 Occupational Radiation Exposure Report provides an evaluation of DOE-wide performance regarding compliance with Title 10, Code of Federal Regulations (C.F.R.), Part 835, Occupational Radiation Protection dose limits and as low as reasonably achievable (ALARA) process requirements. In addition, the report provides data to DOE organizations responsible for developing policies for protection of individuals from the adverse health effects of radiation. The report provides a summary and an analysis of occupational radiation exposure information from the monitoring of individuals involved in DOE activities. Over the past 5-year period, the occupational radiation exposure information is analyzed in terms of aggregate data, dose to individuals, and dose by site. As an indicator of the overall amount of radiation dose received during the conduct of operations at DOE, the report includes information on collective total effective dose (TED). The TED is comprised of the effective dose (ED) from external sources, which includes neutron and photon radiation, and the internal committed effective dose (CED), which results from the intake of radioactive material into the body. The collective ED from photon exposure decreased by 23% between 2011 and 2012, while the neutron dose increased by 5%. The internal dose components of the collective TED decreased by 7%. Over the past 5-year period, 99.99% of the individuals receiving measurable TED have received doses below the 2 roentgen equivalent in man (rems) (20 millisievert [mSv]) TED administrative control level (ACL), which is well below the DOE regulatory limit of 5 rems (50 mSv) TED annually. The

  15. Natural radioactivity in construction materials and the resulting radiation exposure

    International Nuclear Information System (INIS)

    The BfS report on the natural radioactivity in construction materials and the resulting radiation exposure covers the following topics: Procedures of sampling. Measuring methods: measurement of the specific activity (gamma spectrometry, determination of the radon exhalation). Radiation exposure estimation: radon exposure, external radiation exposure. Measuring results: specific activity, radon exhalation, total exposure. Evaluation of the natural radioactivity of construction materials: overview on the existing requirements of the radiation protection law, EU recommendations ''Radiation Protection 112'', Austrian norm S 5200 ''radioactivity on construction materials (OeNORM). EU basic norm draft, requirements according building laws. BfS evaluation proposal.

  16. Anxiogenic-like effects of chronic nicotine exposure in zebrafish.

    Science.gov (United States)

    Stewart, Adam Michael; Grossman, Leah; Collier, Adam D; Echevarria, David J; Kalueff, Allan V

    2015-12-01

    Nicotine is one of the most widely used and abused legal drugs. Although its pharmacological profile has been extensively investigated in humans and rodents, nicotine CNS action remains poorly understood. The importance of finding evolutionarily conserved signaling pathways, and the need to apply high-throughput in vivo screens for CNS drug discovery, necessitate novel efficient experimental models for nicotine research. Zebrafish (Danio rerio) are rapidly emerging as an excellent organism for studying drug abuse, neuropharmacology and toxicology and have recently been applied to testing nicotine. Anxiolytic, rewarding and memory-modulating effects of acute nicotine treatment in zebrafish are consistently reported in the literature. However, while nicotine abuse is more relevant to long-term exposure models, little is known about chronic effects of nicotine on zebrafish behavior. In the present study, chronic 4-day exposure to 1-2mg/L nicotine mildly increased adult zebrafish shoaling but did not alter baseline cortisol levels. We also found that chronic exposure to nicotine evokes robust anxiogenic behavioral responses in zebrafish tested in the novel tank test paradigm. Generally paralleling clinical and rodent data on anxiogenic effects of chronic nicotine, our study supports the developing utility of zebrafish for nicotine research. PMID:25643654

  17. Some radiation exposure problems in hysterosalpingography procedures

    International Nuclear Information System (INIS)

    While stressing the diagnostic usefulness of hysterosalpingography in gynecological practice, the authors point out that generally much unjustified radiation exposure occurs during the procedure, affecting both the subjects investigated - usually women of reproductive age - and the attending personnel. Common faults in this respect are: disregard to preliminaries (team-work coordination, information on patient's condition), inadequate adaptation, roentgenoscopic examinations small in number but of long duration, a tendency to follow on the screen some aspects of the filling of genital tract sections that are of no particular relevance to diagnostic, quite unsatisfactory limitation of diaphragm aperture resulting in a 4 to 5 and even more times larger field than necessitated by the object of the investigation, either in roentgenoscopy or roentgenography, etc. The authors have measured the times of individual hysterosalpingography phases and present an analysis of a number of end-points: mean duration of the procedure, relative roentgenoscopic time, number of roentgenoscopic examinations, scopy-to-film ratio, failure to use maximum diaphragm-aperture constriction, etc. To achieve higher reliability, data were collected from 100 patient examinations involving one radiologist and three gynecologists. Finally, recommendations are given for a reasonable hysterosalpingography procedure aimed at reducing radiation exposure to female patients of reproductive age as well as medical personnel and providing permanent records by means of a larger number of films obtained under routine conditions instead of resorting to roentgenoscopic examinations of long duration associated with appreciable amounts of excessive exposure. (author)

  18. Radiation Exposure to Concrete in Israel

    International Nuclear Information System (INIS)

    Most building materials of terrestrial origin contain small amounts of radionuclides of natural origin, mainly from the Uranium (238U) and Thorium (232Th) decay chains and the radioactive isotope of potassium, 40K. The external radiation exposure is caused by gamma emitting radionuclides, which in the uranium series mainly belong to the decay chain segment starting with Radium (226Ra). The internal (by inhalation) radiation exposure is due to Radon (222Rn), and its short lived decay products, exhaled from building materials into the room air. Due to economical and environmental reasons there is an increased tendency to use industrial by-products containing relatively high concentrations of radionuclides of natural origin in the building material industry. Fly ash (FA), produced as by-product in the combustion of coal, is extensively used in Israel since mid eighties of the last century in concrete and as an additive to cement . The increase of 226Ra activity concentration, the mineralogical characteristics of the FA and of the concrete may influence on the radon exhalation rate and consequently on the radon exposure of the public. The recently published Israeli Standard 5098 (IS 5098) 'Content of natural radioactive elements in building products' limits the content of natural radionuclides as well as the radon emanation from concrete. This paper presents a compilation of three studies conducted at Soreq Nuclear Research Centre (SNRC), Technion, NRG and Environmental Lab BGU (ELBGU) to investigate and quantify the influence of FA addition in concrete

  19. Report on emergency exposure to external radiation

    International Nuclear Information System (INIS)

    The Medical Research Council has continued a study of the effects on the health of persons in the neighbourhood of atomic energy installations should there be a release of radioactive material as a result of fires or other incidents. The Council's Committee on Protection against Ionizing Radiations has already reported (Medical Research Council, 1959) on the maximum permissible dietary contamination for iodine 131, strontium 89, strontium 90 and caesium. 137, since it was considered that for the members of the public normally resident in the area affected ingestion of contaminated food would generally be the limiting source of hazard after any such accident and that intake by inhalation, or radiation from the exterior, would become of importance only in rather special circumstances The present report deals with the problem of exposure from the exterior, namely, from external sources of beta and gamma radiation. This exposure might be derived from two sources, one of relatively short duration from the passage of a cloud of radioactive material, the other of longer duration from deposited material

  20. Microwave radiation: biological effects and exposure standards

    Energy Technology Data Exchange (ETDEWEB)

    Lindsay, I.R.

    1981-01-01

    The thermal effects of microwave radiation are well recognized and are discussed with particular reference to cataractogenesis; the possibility of an association cannot be questioned. Postulated nonthermal effects comprise an asthenic syndrome, and for the most part the disturbances lie within clinical norms and tolerances, and are reversible. World opinion on safe exposure levels for microwave radiation is varied, and this had led to national standards disparate by three to four orders of magnitude. The US and UK exposure standard of 10 mW/cm/sup 2/ was determined over two decades ago; the possibility of a change to a more restrictive level, in line with other countries, in the near future is examined. It is concluded that such a change, without scientific rationale, is not justified. Some biological implications of the microwave radiation from the solar power satellite are considered in terms of precautions to be taken by personnel working in the vicinity of the rectenna, effects on cardiac pacemakers, and any potential effects on birds. 14 references.

  1. Association of radiation-induced genes with noncancer chronic diseases in Mayak workers occupationally exposed to prolonged radiation.

    Science.gov (United States)

    Abend, Michael; Azizova, Tamara; Müller, Kerstin; Dörr, Harald; Doucha-Senf, Sven; Kreppel, Helmut; Rusinova, Galina; Glazkova, Irina; Vyazovskaya, Natalia; Unger, Kristian; Braselmann, Herbert; Meineke, Viktor

    2015-03-01

    We examined the association of gene expression with noncancer chronic disease outcomes in Mayak nuclear weapons plant workers who were exposed to radiation due to their occupation. We conducted a cross-sectional study with selection based on radiation exposure status of Mayak plant workers living in Ozyorsk who were alive in 2011 and either exposed to: combined incorporated Plutonium-239 ((239)Pu) and external gamma-ray exposure (n = 82); external gamma-ray exposure alone (n = 18); or were unexposed (n = 50) of Ozyorsk residents who provided community-based professional support for plant personnel and who were alive in 2011. Peripheral blood was taken and RNA was isolated and then converted into cDNA and stored at -20°C. In a previous analysis we screened the whole genome for radiation-associated candidate genes, and validated 15 mRNAs and 15 microRNAs using qRT-PCR. In the current analysis we examined the association of these genes with 15 different chronic diseases on 92 samples (47 males, 45 females). We examined the radiation-to-gene and gene-to-disease associations in statistical models stratified by gender and separately for each disease and exposure. We modeled radiation exposure as gamma or (239)Pu on both the continuous and categorical scales. Unconditional logistic regression was used to calculate odds ratios (OR), 95% confidence intervals (CI), and the concordance for genes that were significantly associated with radiation exposure and a specific disease outcome were identified. Altogether 12 mRNAs and 9 microRNAs appeared to be significantly associated with 6 diseases, including thyroid diseases (3 genes, OR: 1.2-5.1, concordance: 71-78%), atherosclerotic diseases (4 genes, OR: 2.5-10, concordance: 70-75%), kidney diseases (6 genes, OR: 1.3-8.6, concordance: 69-85%), cholelithiasis (3 genes, OR: 0.2-0.3, concordance: 74-75%), benign tumors [1 gene (AGAP4), OR: 3.7, concordance: 81%] and chronic radiation syndrome (4 genes, OR: 2.5-4.3, concordance: 70

  2. Melatonin protection from chronic, low-level ionizing radiation.

    Science.gov (United States)

    Reiter, Russel J; Korkmaz, Ahmet; Ma, Shuran; Rosales-Corral, Sergio; Tan, Dun-Xian

    2011-12-15

    In the current survey, we summarize the published literature which supports the use of melatonin, an endogenously produced molecule, as a protective agent against chronic, low-level ionizing radiation. Under in vitro conditions, melatonin uniformly was found to protect cellular DNA and plasmid super coiled DNA from ionizing radiation damage due to Cs(137) or X-radiation exposure. Likewise, in an in vivo/in vitro study in which humans were given melatonin orally and then their blood lymphocytes were collected and exposed to Cs(137) ionizing radiation, nuclear DNA from the cells of those individuals who consumed melatonin (and had elevated blood levels) was less damaged than that from control individuals. In in vivo studies as well, melatonin given to animals prevented DNA and lipid damage (including limiting membrane rigidity) and reduced the percentage of animals that died when they had been exposed to Cs(137) or Co(60) radiation. Melatonin's ability to protect macromolecules from the damage inflicted by ionizing radiation likely stems from its high efficacy as a direct free radical scavenger and possibly also due to its ability to stimulate antioxidative enzymes. Melatonin is readily absorbed when taken orally or via any other route. Melatonin's ease of self administration and its virtual absence of toxicity or side effects, even when consumed over very long periods of time, are essential when large populations are exposed to lingering radioactive contamination such as occurs as a result of an inadvertent nuclear accident, an intentional nuclear explosion or the detonation of a radiological dispersion device, i.e., a "dirty" bomb. PMID:22185900

  3. Exposure to natural radiation and its regulation

    International Nuclear Information System (INIS)

    The natural radiation exists everywhere from the birth of the earth and the main component is cosmic ray and terrestrial γray. The natural radioactive nuclides are of the uranium series, thorium series, potassium 40 and others. The average uranium content is 1 g/t (id est (i.e.) 0.01 Bq/g) order in the crust and the content of thorium is one order higher than uranium content. In Japan the average annual external exposure is 0.76 mSv (0.3 mSv from cosmic ray, 0.44 mSv from terrestrial γray) and the exposure to radon and thoron progeny is 0.56 mSv, and the exposure by intake of food is 0.8 mSv. Japanese takes much sea food and therefore the exposure to Po-210 is pretty high. Japanese government does not yet regulate the NORM and radon, and the risks of other materials and events, the clearance level and the dose after the period for active control of radioactive waste should be considered on the legislation. (author)

  4. Radiation exposure during cardiac catheterization procedures

    International Nuclear Information System (INIS)

    For some time there has been an increased interest in more information about radiation exposure during cardiac catheterization because of: relatively high doses to workers and patient; rapid increase of numbers of examinations; introduction of new procedure-types (e.g. Percutaneous Transluminal Coronary Angiography, PTCA) and introduction of new techniques (e.g. Digital Subtraction Angiography, DSA). This paper reports about a study on the exposure to medical personnel and patient in two major hospitals in the Netherlands. The Total number of cardiac catheterization procedures in both hospitals amounts to circa 3000 per year (approximately 10% of all cardiac procedures c.q. 20% of all PTCA procedures in the Netherlands). This study is related to 1300 cardiac examinations

  5. Chemical and physical knowledge about radiation exposure

    International Nuclear Information System (INIS)

    Easily explained is the title subject about the electromagnetic wave, photon, neutron, particle line, linear energy transfer and unit. The electromagnetic wave is a waving particle, photon, without mass and generally involves radio, infrared, visible, ultraviolet and gamma (and X) rays. The interaction between photon and material atom involves effects photoelectric, yielding electron pair, Compton scattering and nuclear in the order of photon energy: respectively important in low energy imaging like mammography vs high exposure dose; positron emit tomography (PET); cause of image fading or source of radiation therapy; and at >7 MeV photon (e.g., linac therapy), the nuclear reaction-generated neutron, hazardous to radiological staff. Neutron has no electric charge and should be shielded by light atoms like H and C as energy loss by collision is efficient. Alpha ray generated by the reaction 10B(n, alpha) 7Li can effectively kill cancer cells. Particle line involves alpha and beta rays. Alpha particle from Rn is sometimes problematic for human health because Ra contained in building materials produces Rn. Beta ray is one of causes of exposure and produces Bremsstrahlung X-ray at its stoppage, which is used for imaging of 89Sr and so on. Beta ray from 40K is important in the internal exposure as the atom in the body amounts to 55 Bq/kg body weight. Effects of radiation depend on its range and ionization in the body: the linear energy transfer (LET) describes the degree of the effects. Unit contains that of the exposure (dose of irradiation) and absorption, and of the radioactivity: the first is expressed by R (roentgen), measurable with the direct ionization effect; the second, Gy (gray), calculable from R; and the third, the decay rate of radionuclide, disintegration per sec (dps) =1 Bq (becquerel). The equivalent doses are expressed by Sv (sievert). (T.T.)

  6. Intrauterine radiation exposures and mental retardation

    International Nuclear Information System (INIS)

    Small head size and mental retardation have been known as effects of intrauterine exposure to ionizing radiation since the 1920s. In the 1950s, studies of Japanese atomic-bomb survivors revealed that at 4-17 wk of gestation, the greater the dose, the smaller the brain (and head size), and that beginning at 0.5 Gy (50 rad) in Hiroshima, mental retardation increased in frequency with increasing dose. No other excess of birth defects was observed. Otake and Schull (1984) pointed out that the period of susceptibility to mental retardation coincided with that for proliferation and migration of neuronal elements from near the cerebral ventricles to the cortex. Mental retardation could be the result of interference with this process. Their analysis indicated that exposures at 8-15 wk to 0.01-0.02 Gy (1-2 rad) doubled the frequency of severe mental retardation. This estimate was based on small numbers of mentally retarded atomic-bomb survivors. Although nuclear accidents have occurred recently, new cases will hopefully be too rare to provide further information about the risk of mental retardation. It may be possible, however, to learn about lesser impairment. New psychometric tests may be helpful in detecting subtle deficits in intelligence or neurodevelopmental function. One such test is PEERAMID, which is being used in schools to identify learning disabilities due, for example, to deficits in attention, short- or long-term memory, or in sequencing information. This and other tests could be applied in evaluating survivors of intrauterine exposure to various doses of ionizing radiation. The results could change our understanding of the safety of low-dose exposures

  7. DOE 2008 Occupational Radiation Exposure October 2009

    Energy Technology Data Exchange (ETDEWEB)

    U.S. Department of Energy, Office of Health, Safety and Security

    2009-10-01

    A major priority of the U.S. Department of Energy (DOE) is to ensure the health, safety, and security of DOE employees, contractors, and subcontractors. The Office of Health, Safety and Security (HSS) provides the corporate-level leadership and strategic vision necessary to better coordinate and integrate health, safety, environment, security, enforcement, and independent oversight programs. One function that supports this mission is the DOE Corporate Operating Experience Program that provides collection, analysis, and dissemination of performance indicators, such as occupational radiation exposure information. This analysis supports corporate decision-making and synthesizes operational information to support continuous environment, safety, and health improvement across the DOE complex.

  8. Ultraviolet Radiation Exposure Criteria (invited paper)

    International Nuclear Information System (INIS)

    During the past 25 years occupational health and safety guidelines, regulations and standards have evolved to protect workers and the general public from potentially hazardous exposure to ultraviolet radiation. A further goal has been to promote the safe design and use of suntanning devices, optical instruments, lamps, and laser products. From the gradually expanding knowledge of the biological effects of UVR exposure of the eye and skin, exposure limits have been slightly revised over the past two decades - by both national and international organisations. The general trend has been a convergence of differing limits. The greatest divergence in guidelines and standards has occurred where the biological effects are least understood or are simply controversial. Philosophical differences in the level of protection have played a role, since there are those who argue that UVR exposure offers more benefit than is accepted by all. The earliest guidelines were limited to UVR from low-pressure mercury lamps used in germicidal applications in the 1940s. By 1972 a North-American guideline based upon an envelope action spectrum had appeared. The International Non-Ionizing Radiation Committee (INIRC) of the International Radiation Protection Association (IRPA) proposed similar guidelines in 1985 and these were revised based upon newer data a few years later. After an extensive review of the IRPA/INIRC guidelines, the International Commission on Non-Ionizing Radiation Protection revalidated and endorsed those limits. Although these guidelines were based firstly on preventing any acute effects, they have also been analysed to show that the risk is extremely small, or undetectable, for delayed effects for persons exposed below these recommended limits. The limits are approximately one-third of an MED (for fair skin) in any eight-hour period. At this level, detectable molecular damage appears to be fully repaired. Further refinement is still called for. For example, the maximal

  9. Effective radiation exposure in digital volume tomography

    International Nuclear Information System (INIS)

    Measurements of the effective doses and the organ doses using head phantoms are supposed to study the effects of different resolutions, volumes and field of view positions on the patient's radiation exposure during digital volume tomography. The details of the measuring instruments and the different volume tomography devices from KaVo are described. All the resulting dose values are related to the specific phantom and were calculated using the average values from ICRP, i.e. these values can be used as reference but cannot be transferred to patients. Therefore significant differences can be seen in comparison with other studies.

  10. Radiation exposure measurement onboard civil aircraft

    International Nuclear Information System (INIS)

    The active dosemeter DOSTEL based on two silicon planar detectors was flown on civil aircraft flights to study the radiation exposure of air crew members. The altitude and latitude dependence of count and dose rates as well as long-term variations are measured. After calibration of the DOSTEL response against measurements of a TEPC instrument, total dose-equivalent values for various flights are compared with H*(10) calculations by EPCARD yielding a ratio of 1.02 ± 0.09 (standard variation). (authors)

  11. Colony formation of the western harvester ant in a chronic gamma radiation field

    International Nuclear Information System (INIS)

    A colony of Western harvester ants, Pogonomyrmex occidentalis, became established in a chronically exposed gamma radiation field located on the native short-grass plains of Colorado. The exposure level at the nest site was 18 R/hr. At the end of the colony's first and second seasons the nest mound diam were 25 and 36 cm, respectively. There were no apparent habitat modifications to suggest any avoidance response to the radiation. (U.S.)

  12. Radiation-induced stress effects following low dose exposure

    International Nuclear Information System (INIS)

    Complete text of publication follows. Recent advances in our understanding of effects of radiation on living cells suggest that fundamentally different mechanisms are operating at low doses compared with high doses. Also, acute low doses appear to involve different response mechanisms compared with chronic low doses. Both genomic instability and so called 'bystander effects' show many similarities with well known cellular responses to oxidative stress. These predominate following low dose exposures and are maximally expressed at doses as low as 5mGy. At the biological level this is not surprising. Chemical toxicity has been known for many years to show these patterns of dose response. Cell signaling and coordinated stress mechanisms appear to dominate acute low dose exposure to chemicals. Adaptation to chemical exposures is also well documented although mechanisms of adaptive responses are less clear. In the radiation field adaptive responses also become important when low doses are protracted or fractionated. Recent data from our group concerning bystander effects following multiple low dose exposures suggest that adaptive responses can be induced in cells which only receive signals from irradiated neighbours. We have data showing delayed and bystander effects in humans, rodents 3 fish species and in prawns following in vitro and/or in vivo irradiation of haematopoietic tissues and, from the aquatic groups, gill and skin/fin tissue. Bystander signals induced by radiation can be communicated from fish to fish in vivo and are detectable as early as the eyed egg stage, i.e. as soon as tissue starts to develop. Using proteomic approaches we have determined that the bystander and the direct irradiation proteomes are different. The former show significant upregulation of 5 proteins with anti-oxidant, regenerative and restorative functions while the direct radiation proteome has 2 upregulated proteins both involved in proliferation. These data have implications for

  13. European studies on occupational radiation exposure

    International Nuclear Information System (INIS)

    The E.S.O.R.E.X. project was initiated by the European Commission in 1997. The objectives of this European study are: 1) to provide the European Commission and the national competent radiation protection authorities with reliable information on how personal radiation monitoring, reporting and recording of dosimetric results is organised in European countries. 2)To collect reliable and directly comparable data on individual and collective radiation exposure in all occupational sectors where radiation workers are employed. Recently the project continues with the name 'E.S.O.R.E.X. 2005' and managed under the responsibility of the State Office for Nuclear Safety of the Czech Republic (S.U.J.B.). The study is performed in close co-operation with the German B.f.S., which was leading the three previous E.S.O.R.E.X. studies: E.S.O.R.E.X. West, E.S.O.R.E.X. East and E.S.O.R.E.X. 2000. E.S.O.R.E.X. 2005 is scheduled for the next three years and the main goals will be to finalize the updating of the country reports by describing the current situation on the field of occupational exposure control, evaluation and registration of personal doses of radiation workers and as a second part of the study, to collect dosimetric data for the period of the years 2001- 2005. In the beginning of the E.S.O.R.E.X. 2005 study the 3. E.S.O.R.E.X. workshop has been organised in the year 2004. The meeting was aimed to present and discus the actual problems identified during the performance of E.S.O.R.E.X. studies and also to establish the ground for an European network that sets up personal contacts and encourages to mutual information exchange in the field of occupational exposure evaluation, regulation and registration and of another related problems. For this purpose a special web site www.esorex.cz has been created where also the discussing forum for certain problems is open. The poster will present the main feedback, highlights and results from the recent and also previous studies and from

  14. Hepatotoxic potential of combined toluene-chronic ethanol exposure

    Energy Technology Data Exchange (ETDEWEB)

    Howell, S.R.; Christian, J.E.; Isom, G.E.

    1986-05-01

    The hepatoxic properties of concurrent chronic oral ethanol ingestion and acute toluene inhalation were evaluated. Male rats were maintained on ethanol-containing or control liquid diets for 29 days. Animals of each group were subjected to five 20-min exposures to 10 000 ppm toluene with 30 min of room air inhalation between exposures on days 22, 24, 26, and 28 of liquid diet feeding. Some of the ethanol-fed animals were withdrawn from ethanol 14 h before exposure. Ethanol-withdrawn animals displayed an increased sensitivity to the narcotic action of toluene. Animals were sacrificed and assays performed on day 29. Stress markers (plasma corticosterone, free fatty acid, and glucose) were not affected by treatments. A modest elevation in plasma aspartate amino-transferase occurred in non-withdrawn animals receiving both ethanol and toluene. Ethanol-toluene exposure increased both relative liver weight and liver triglycerides. Toluene antagonized the hypertriglyceridemia associated with chronic ethanol ingestion. This study indicates that combined ethanol and toluene exposure has minor potential to induce acute liver injury, but results in altered deposition of hepatic triglycerides.

  15. Monitoring of radiation exposure. Annual report 2000

    International Nuclear Information System (INIS)

    At the end of 2000, there were 1,779 valid safety licenses in Finland for the use of radiation. In addition, there were 2,038 responsible parties for dental x-ray diagnostics. The registry Radiation and Nuclear Safety Authority (STUK) listed 13,754 radiation sources and 270 radionuclide laboratories. In the year 2000 360 inspections were made concerning the safety licences and 53 concerning dental x-ray diagnostics. The import of radioactive substances amounted to 175,836 GBq and export to 74,420 GBq. Short-lived radionuclides produced in Finland amounted to 55,527 GBq. In the year 2000 there were 10,846 workers monitored for radiation exposure at 1,171 work sites. Of these employees, 27% received an annual dose exceeding the recording level. The annual effective dose limit was not exceeded. The total dose recorded in the dose registry(sum of the individual dosemeter readings) was 6.5 Sv in 2000

  16. Cosmic radiation exposure at aircraft crew workplaces

    International Nuclear Information System (INIS)

    E.U.R.A.D.O.S. working group W.G.5. on air crew dosimetry coordinated research of some 24 international institutes to exchange experimental data and results of calculations of the radiation exposure in aircraft altitudes due to cosmic radiation. The purpose was to provide a data-set for all European Union Member States for the assessment of individual doses, the validity of different approaches, and to provide an input to technical recommendations by the Article 31 group of experts and the European Commission. The results of this work have been recently published and are available for the international community. The radiation protection quantity of interest is effective dose, E (ISO), but the comparison of measurement results and the results of calculations, is done in terms of the operational quantity ambient dose equivalent, H*(10). This paper gives an overview of the E.U.R.A.D.O.S. Aircraft Crew In-Flight Database which was implemented under the responsibility of A.R.C. Seibersdorf research. It discusses calculation models for air crew dose assessment comparing them with measurements contained in this database. Further it presents current developments using updated information of galactic cosmic radiation proton spectra and new results of the recently finalized European research project D.O.S.M.A.X. on dosimetry of aircraft crew at solar maximum. (authors)

  17. Cosmic radiation exposure at aircraft crew workplaces

    Energy Technology Data Exchange (ETDEWEB)

    Latocha, M.; Beck, P.; Rollet, S. [ARC Seibersdorf Research, Seibersdorf (Austria); Latocha, M. [Institute of Nuclear Physics Polish Academy of Sciences, Krakow (Poland)

    2006-07-01

    E.U.R.A.D.O.S. working group W.G.5. on air crew dosimetry coordinated research of some 24 international institutes to exchange experimental data and results of calculations of the radiation exposure in aircraft altitudes due to cosmic radiation. The purpose was to provide a data-set for all European Union Member States for the assessment of individual doses, the validity of different approaches, and to provide an input to technical recommendations by the Article 31 group of experts and the European Commission. The results of this work have been recently published and are available for the international community. The radiation protection quantity of interest is effective dose, E (ISO), but the comparison of measurement results and the results of calculations, is done in terms of the operational quantity ambient dose equivalent, H{sup *}(10). This paper gives an overview of the E.U.R.A.D.O.S. Aircraft Crew In-Flight Database which was implemented under the responsibility of A.R.C. Seibersdorf research. It discusses calculation models for air crew dose assessment comparing them with measurements contained in this database. Further it presents current developments using updated information of galactic cosmic radiation proton spectra and new results of the recently finalized European research project D.O.S.M.A.X. on dosimetry of aircraft crew at solar maximum. (authors)

  18. Sensitivity of Trout to Chronic Acute Exposure to Selenium

    DEFF Research Database (Denmark)

    Nielsen, Gunnar Gissel; Nielsen, M. Gissel

    1978-01-01

    Trout were exposed to selenite (Na2SeO3) solutions of varying concentrations (0.1-100 ppm Se) for periods of up to 4 wk. A chronic exposure to 0.1 ppm Se or less is non-lethal to trout. Lethality at higher concentrations depends on the length of exposure. Trout that survive for 10 days in tap......-water after contamination will not die as a result of Se toxicity and can safely be used for human consumption....

  19. Creation of a crystalline lens radiation exposure defense cover and the effect of radiation exposure decrease on neuro-interventions

    International Nuclear Information System (INIS)

    A variety of radiation hazards resulting from interventional radiology (IVR) have been reported in recent years. Particularly affected are the skin and the crystalline lens, with their high radiation sensitivity. During neurological interventions, the radiological technologist should consider decreasing radiation exposure. We found exposure projections where the exposure dose became a radiation hazard for the crystalline lens, and examined an efficient method of cover for the exposure projections used for neurological interventions. The exposure projection for maximum crystalline lens radiation exposure was a lateral projection. In the crystalline lens the maximum exposure to radiation was on the X-ray tube side. The method of defense adopted was that of installing a lead plate of the appropriate shape on the surface of the X-ray tube collimator. In other exposure projections, this cover did not become a redundant shadow. With the cover that was created, the X-ray side crystalline lens lateral projection could be defended effectively. (author)

  20. Does chronic exposure to mobile phones affect cognition?

    OpenAIRE

    Mohan, Mamta; Khaliq, Farah; Panwar, Aprajita; Vaney, Neelam

    2016-01-01

    Mobile phones form an integral part of our modern lifestyle. Following the drastic rise in mobile phone use in recent years, it has become important to study its potential public health impact. Amongst the various mobile phone health hazards, the most alarming is the possible effect on the brain. The aim of the present study was to explore whether chronic exposure to mobile phones affects cognition. Ninety subjects aged 17–25 years with normal hearing were recruited for the study and divided ...

  1. Analysis of reproductive function in persons exposed to chronic radiation

    International Nuclear Information System (INIS)

    The purpose of the study was to analyze the reproductive function in individuals exposed to radiation in the riverside villages on the Techa in the Southern Urals. The exposure of the population, numbering 28000, occurred in 1950-1956 as a result of discharges into the river of radioactive wastes from the Mayak facility for processing weapon plutonium. The residents were exposed to chronic radiation, both external and internal. The range of exposure doses to gonads was sufficiently wide: 20-1270 mSv. However, the distribution of doses among the exposed individuals was ununiform, and the proportion of people whose dose was below 120 mGy accounted for 74%. The following characteristics of exposed women were analyzed: menstrual function, outcomes of pregnancy, birth rates, health status for newborns. The analysis of the menstrual function in exposed women showed that in persons exposed in childhood, menarche was registered at the age of 14.3 years, on the average (based on literature sources, menarche is attained at the age of 13 for unexposed population). The mean age at menopause was 47.9 years for exposed women (the respective mean value for Russia is 50.8 years). Pregnancy outcomes were analyzed in 9000 exposed women. The rate of medical and criminal abortions was estimated as 79 per 100 labors. The rate of spontaneous abortions for exposed women was slightly higher, 3.11%, than for controls, 2.30%; these difference, however, were statistically insignificant. The total loss of fetus or neonate (unfavorable outcomes of pregnancy: spontaneous abortions, stillbirths, early neonatal death) was estimated to be 4.58% at zero dose. Exposure to gonads at the dose 1 Sv, estimated using the above-indicated method, yielded 3% of additional unfavorable outcomes of pregnancy. It was shown, based on the analysis of birth rates for the Techa Cohort that they had not undergone any essential changes over the first 25 years of exposure compared to the respective coefficients for

  2. Analysis of reproductive function in persons exposed to chronic radiation

    Energy Technology Data Exchange (ETDEWEB)

    Kossenko, M.M.; Ostroumova, E.V.; Vyushkova, O.V. [Urals Research Center for Radiation Medicine, Chelyabinsk (Russian Federation)

    2000-05-01

    The purpose of the study was to analyze the reproductive function in individuals exposed to radiation in the riverside villages on the Techa in the Southern Urals. The exposure of the population, numbering 28000, occurred in 1950-1956 as a result of discharges into the river of radioactive wastes from the Mayak facility for processing weapon plutonium. The residents were exposed to chronic radiation, both external and internal. The range of exposure doses to gonads was sufficiently wide: 20-1270 mSv. However, the distribution of doses among the exposed individuals was ununiform, and the proportion of people whose dose was below 120 mGy accounted for 74%. The following characteristics of exposed women were analyzed: menstrual function, outcomes of pregnancy, birth rates, health status for newborns. The analysis of the menstrual function in exposed women showed that in persons exposed in childhood, menarche was registered at the age of 14.3 years, on the average (based on literature sources, menarche is attained at the age of 13 for unexposed population). The mean age at menopause was 47.9 years for exposed women (the respective mean value for Russia is 50.8 years). Pregnancy outcomes were analyzed in 9000 exposed women. The rate of medical and criminal abortions was estimated as 79 per 100 labors. The rate of spontaneous abortions for exposed women was slightly higher, 3.11%, than for controls, 2.30%; these difference, however, were statistically insignificant. The total loss of fetus or neonate (unfavorable outcomes of pregnancy: spontaneous abortions, stillbirths, early neonatal death) was estimated to be 4.58% at zero dose. Exposure to gonads at the dose 1 Sv, estimated using the above-indicated method, yielded 3% of additional unfavorable outcomes of pregnancy. It was shown, based on the analysis of birth rates for the Techa Cohort that they had not undergone any essential changes over the first 25 years of exposure compared to the respective coefficients for

  3. Exposure of Finnish population to ultraviolet radiation and radiation measurements

    International Nuclear Information System (INIS)

    This report is based on a survey of the literature on radiation risks involved in sunbathing and the use of solaria. The purpose of the report is to provide background information for the development of regulations on solaria and for informing the public about the risks posed by solaria and the sun. The report gives an overview of the properties and biological effects of ultraviolet radiation. The most important regulations and recommendations issued in various countries are presented. The connection between ultraviolet radiation and the risks of skin cancer is examined both on a general level and in reference to information obtained from the Finnish Cancer Registry. In Finland, the incidence of melanomas nearly tripled between 1960 and 1980. The most important cause is considered to be the population's increased exposure to the su's ultraviolet radiation. There are no reliable data on the connection between the use of solaria and the risks of skin cancer. It is estimated, however, that solaria account for less than 10 per cent of the skin cancer risk of the whole population. There are some difficult physical problems associated with the measurement of ultraviolet radiation emitted by both natural sources and solaria. A preliminary study of these problems has been undertaken by means of a survey of the available literature, supplemented by a review of measurements performed by the Finnish Centre For Radiation and Nuclear Safety. The estimated inaccuracy of the Optronic 742 spectroradiometer used by the Centre in the measurement of ultraviolet radiation emitted by the sun and solaria is about +-14%

  4. Breast cancer induced by protracted radiation exposures

    International Nuclear Information System (INIS)

    The experience at Hiroshima/Nagasaki demonstrated that breast cancer can be induced by single doses of ionizing radiation following latencies of 10-40 years. Several epidemiological studies, usually involving ancillary low-LET radiation to the breast, have demonstrated that breast cancer can be induced by protracted exposures, with similar latencies, and with similar dependencies on dose. Radiobiologically these results suggest that the target cells involved were deficient in repair of low-LET damage even when the protraction was over months to years. Since three-quarters of breast tumors originate in the ducts where their proliferation is controlled by menstrual-cycle timed estrogen/progesterone secretions, these cells periodically were in cycle. Thus, the two main elements of a conceptual model for radon-induced lung cancer -- kinetics and deficient repair -- are satisfied. The model indicates that breast cancer could be the cumulative effect of protracted small exposures, the risk from any one of which ordinarily would be quite small. (author)

  5. Radiation exposures for DOE and DOE contractor employees, 1987

    International Nuclear Information System (INIS)

    This report is one of series of annual reports provided by the US Department of Energy (DOE) summarizing occupational radiation exposures received by DOE and DOE contractor employees. These reports provide an overview of radiation exposures received each year, as well as identification of trends in exposures being experienced over the years. 5 figs., 30 tabs

  6. Occupational exposure to natural radiation in Brazil

    International Nuclear Information System (INIS)

    The mining, milling and processing of uranium and thorium bearing minerals may result in radiation doses to workers. A preliminary survey pilot program, that included six mines in Brazil (two coal mines, one niobium mine, one nickel mine, one gold mine and one phosphate mine), was launched in order to determine the need to control the radioactive exposure of the mine-workers. Our survey consisted of the collection and analysis of urine samples, complemented by feces and air samples. The concentrations of uranium, thorium and polonium were measured in these samples and compared to background data from family members of the workers living in the same dwelling and from residents from the general population of Rio de Janeiro. The results from the coal mines indicated that the inhalation of radon progeny may be a source of occupational exposure. The workers from the nickel, gold and phosphate mines that were visited do not require a program to control internal radiological doses. The niobium mine results showed that in some areas of the industry exposure to thorium and uranium might occur. (author)

  7. GPU Nuclear Corporation's radiation exposure management system

    International Nuclear Information System (INIS)

    GPU Nuclear Corporation has developed a central main frame (IBM 3081) based radiation exposure management system which provides real time and batch transactions for three separate reactor facilities. The structure and function of the data base are discussed. The system's main features include real time on-line radiation work permit generation and personnel exposure tracking; dose accountability as a function of system and component, job type, worker classification, and work location; and personnel dosemeter (TLD and self-reading pocket dosemeters) data processing. The system also carries the qualifications of all radiation workers including RWP training, respiratory protection training, results of respirator fit tests and medical exams. A warning system is used to prevent non-qualified persons from entering controlled areas. The main frame system is interfaced with a variety of mini and micro computer systems for dosemetry, statistical and graphics applications. These are discussed. Some unique dosemetry features which are discussed include assessment of dose for up to 140 parts of the body with dose evaluations at 7,300 and 1000 mg/cm2 for each part, tracking of MPC hours on a 7 day rolling schedule; automatic pairing of TLD and self-reading pocket dosemeter values, creation and updating of NRC Forms 4 and 5, generation of NRC required 20.407 and Reg Guide 1.16 reports. As of July 1983, over 20 remote on-line stations were in use with plans to add 20-30 more by May 1984. The system provides response times for on-line activities of 2-7 seconds and 23 1/2 hours per day ''up time''. Examples of the various on-line and batch transactions are described

  8. Changes in blood sugar content of dogs exposed to chronic gamma radiation for 6 years. [Combined effects of physical stress, heat stress, and acute radiation stress

    Energy Technology Data Exchange (ETDEWEB)

    Akhunov, A.A.

    1978-10-26

    There have not been many studies of blood sugar concentration in animals exposed to chronic gamma radiation, and the results thereof are contradictory. Therefore, data on blood sugar levels in dogs during a 6-year exposure to gamma radiation and after discontinuation thereof are reported.

  9. Human exposure to high natural background radiation: what can it teach us about radiation risks?

    Energy Technology Data Exchange (ETDEWEB)

    Hendry, Jolyon H; Sohrabi, Mehdi; Burkart, Werner [Department of Nuclear Sciences and Applications, International Atomic Energy Agency, Vienna (Austria); Simon, Steven L [Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD (United States); Wojcik, Andrzej [Institute of Nuclear Chemistry and Technology, Warsaw (Poland); Cardis, Elisabeth [Centre for Research in Environmental Epidemiology (CREAL), Municipal Institute of Medical Research (IMIM-Hospital del Mar) and CIBER Epidemiologia y Salud Publica - CIBERESP, Barcelona (Spain); Laurier, Dominique; Tirmarche, Margot [Radiobiology and Epidemiology Department, Radiological and Human Health Division, Institute for Radiological Protection and Nuclear Safety, Fontenay-aux-Roses (France); Hayata, Isamu [National Institute of Radiological Sciences, Chiba (Japan)], E-mail: jhendry2002uk@yahoo.com

    2009-06-01

    Natural radiation is the major source of human exposure to ionising radiation, and its largest contributing component to effective dose arises from inhalation of {sup 222}Rn and its radioactive progeny. However, despite extensive knowledge of radiation risks gained through epidemiologic investigations and mechanistic considerations, the health effects of chronic low-level radiation exposure are still poorly understood. The present paper reviews the possible contribution of studies of populations living in high natural background radiation (HNBR) areas (Guarapari, Brazil; Kerala, India; Ramsar, Iran; Yangjiang, China), including radon-prone areas, to low dose risk estimation. Much of the direct information about risk related to HNBR comes from case-control studies of radon and lung cancer, which provide convincing evidence of an association between long-term protracted radiation exposures in the general population and disease incidence. The success of these studies is mainly due to the careful organ dose reconstruction (with relatively high doses to the lung), and to the fact that large-scale collaborative studies have been conducted to maximise the statistical power and to ensure the systematic collection of information on potential confounding factors. In contrast, studies in other (non-radon) HNBR areas have provided little information, relying mainly on ecological designs and very rough effective dose categorisations. Recent steps taken in China and India to establish cohorts for follow-up and to conduct nested case-control studies may provide useful information about risks in the future, provided that careful organ dose reconstruction is possible and information is collected on potential confounding factors.

  10. Information by the German Federal Government. Environmental radioactivity and radiation exposure in 2009

    International Nuclear Information System (INIS)

    The annual report on environmental radioactivity and radiation exposure of the German Federal Government for 2009 includes the following chapters: (1) natural radiation exposure; (2) civilization based radiation exposure (nuclear power plants, nuclear installations, radioactive waste repositories, other radiation sources, Chernobyl accident caused fall-out); (3) occupational radiation exposure; (4) medical radiation exposure; (5) non-ionizing radiation.

  11. Criteria for radiological protection against exposure to natural radiation

    International Nuclear Information System (INIS)

    Exposure of humans to natural sources of radiation has been a continuous and inevitable feature of life on earth. This exposure exceeds all due to artificial sources combined for most people. Many exposures to natural radiation sources are modified by human action. In particular, natural radionuclides are released into the environment in mineral processing and in activities such as the production of phosphate fertilizers and the use of fossil fuels. An increase of exposures to this natural radiation is caused. The relevance of exposure to natural radiation is confirmed by the fact that, for most people, the exposures to natural background radiation have been much more significant than exposures to artificial sources, with exceptions. Among these exceptions have been noted: medical exposures, accidents with release of radionuclides and some specific workplaces. In all cases, however, the natural background radiation has formed the basis on which all the others exposures are added and is a common level serving as compared to other exposures. Regulations and instructions have begun to establish in some countries to regulate natural radiation, countries like Spain, have already incorporated into its regulations on health protection against ionizing radiation the subject of natural radiation. (author)

  12. Intervention in emergency situations involving radiation exposure (1990)

    International Nuclear Information System (INIS)

    This document covers radiation protection aspects arising in emergency situations. It does not cover the measures necessary to reduce the health consequences of radiation exposure, i.e. the medical care of exposed individuals, nor does it cover psychological problems arising from the exposure of individuals or of a population. These problems may arise from anxiety about possible late effects of radiation exposure and from any actions implemented to reduce exposure. Even though radiation exposure levels may be low and insignificant, these problems must be taken into account in determining any action to be implemented to reduce radiation exposure. The primary concern of this document is with exposure in areas which are close to the source and in the period immediately after a source is out of control. It outlines the principles which can be used for planning and implementing countermeasures for protection of the public. 24 refs., 13 tabs

  13. Anthropogenic substances and products containing natural radionuclides. Radiation exposure analysis

    International Nuclear Information System (INIS)

    The anthropogenic component of radiation exposure stems from man's activities. It can be induced both by artificial and natural radionuclides. Radiation exposure due to natural radionuclides can be attributed to anthropogenic materials and products: raw materials, wastes, consumer goods, aricles of daily use. The potential radiation exposure induced by artificial radionuclides is subject to monitoring and rigid regulatory provisions at international level. Recently, exposure from natural radionuclides has become an aspect attracting increasing attention, one major reason being the disturbance detected in the ''normal'' natural background radiation, which is a result of man's activities (modified natural radiation exposure). The lecture briefly reviews the existing laws and regulations and a list of the raw materials, wastes, consumer goods and articles of daily use which contain natural radionuclides. The concluding part discusses results of radiation exposure assessments for a variety of relevant situations and cases. (orig./DG)

  14. Occupational radiation exposures in research laboratories

    International Nuclear Information System (INIS)

    Radioactive sources are widely used in many research activities at University centers. In particular, the activities concerning use of sealed form (57Co in Moessbauer application) and unsealed form (3H, 14C, 32P in radioisotope laboratories) are analyzed. The radiological impact of these materials and potential effective doses to researchers and members of the public were evaluated to show compliance with regulatory limits. A review of the procedures performed by researchers and technicians in the research laboratories with the relative dose evaluations is presented in different situations, including normal operations and emergency situations, for example the fire. A study of the possible exposure to radiation by workers, restricted groups of people, and public in general, as well as environmental releases, is presented. (authors)

  15. Two children with chronic progressive radiation myelopathy

    International Nuclear Information System (INIS)

    We report two patients who developed chronic progressive radiation myelopathy (CPRM). Patient 1 was a 16-year-old boy with group IV rhabdomyosarcoma of cervical soft tissue. He underwent partial excision of the tumor and received systemic and intrathecal chemotherapy and 44 Gy of local radiotherapy (C4 through Th3). These therapies were followed by high-dose chemotherapy including thio-TEPA and busulfan with autologous bone marrow rescue. One year after the completion of the therapies, he developed CPRM. Patient 2 was a 15-year-old girl with acute lymphoblastic leukemia on the 3rd complete remission. She received 18 Gy of irradiation to whole brain during the 1st remission and another 18 Gy to whole brain and 9 Gy to spinal cord after her 1st CNS relapse. After successful reinduction therapy for the 2nd relapse in CNS and bone marrow, she underwent an allogeneic bone marrow transplantation (BMT). The preconditioning regimen consisted of 12 Gy total body irradiation, thio-TEPA and cyclophosphamide. Seven months after BMT, she developed CPRM at C0-C1 level, which was included in the area of whole-brain irradiation. In both patients, MR images showed a swelling of the cervical cord and ring-like images by gadolinium enhancement. Their neurological disability transiently responded to the administration of corticosteroid, but they developed progressive quadriplegia. Although it is reported that a dose of 45-50 Gy may be safe, these cases suggest that administration of high-dose chemotherapy combined with intrathecal chemotherapy and radiotherapy to the cord might increase the rink of developing CPRM. (author)

  16. Risk assessment and management of natural radiation exposures

    International Nuclear Information System (INIS)

    An account is given of the range of natural radiation exposures received both by the general population and by occupationally exposed groups. Particular emphasis is placed in this paper on the cosmic radiation exposures of air crew and on exposures to radon in the workplace. In both these cases exposure and risk assessment procedures are described. Present approaches to the management of these exposures from natural radiation are outlined in particular in the context of the revised European Union Basic Safety Standards Directive which must be implemented in European Union Member States by May 2000. (author)

  17. Radiation exposures in the nuclear maintenance and service industry

    International Nuclear Information System (INIS)

    The recent experience of the Energy Systems Service Division of Westinghouse Electric Corporation indicates that the general trend of radiation exposures in the nuclear maintenance and service industry is favorable and on the edge of a long-sought downward trend. Exposure data obtained over the past six-year period (1980-1986) has been analyzed. Annual exposure for a variety of service job categories shows the positive effect of increased training of service workers and enhancement of service equipment in the reduction of radiation exposure. Service Resource Planning is required to ensure the continuation of radiation exposure reduction in the industry

  18. Cell/Tissue Culture Radiation Exposure Facility Project

    Data.gov (United States)

    National Aeronautics and Space Administration — We propose to develop a Cell/Tissue Culture Radiation Exposure Facility (CTC-REF) to enable radiobiologists to investigate the real-time radiation effects on...

  19. Radiation exposure: Hot legacy of the Cold War

    International Nuclear Information System (INIS)

    The article tells about the routine management of nuclear safety in the U.S.S.R. and, more specifically, about the hazards of long-term exposure to big doses of radiation. Half the workers at the Cheliabinsk site in the Ural Mountains east of Moscow were routinely receiving 100 rem per year in the late 1940s and early 1950s. For comparison, this is about 20 times the maximum annual dose a worker is allowed to get in the United States today. The consequences of the very large doses to workers in the U.S.S.R. are not fully revealed. But the report mentions that 8 to 9% of the staff who began work before 1958 and received high radiation doses (more than 100 rem) die of cancer. In addition, the report says that nearly a quarter of the workers between 1950 and 1952 were suffering from chronic radiation disease. Cancer mortality among severely exposed workers (100 rem and above) was 88% higher than among those who received less than 100 rem

  20. Medical radiation exposure and genetic risks

    International Nuclear Information System (INIS)

    Everyone is exposed to background radiation throughout life (100 mrem/year to the gonads or 4 to 5 rem during the reproductive years). A lumbosacral series might deliver 2500 mrem to the male or 400 mrem to the female gonads. A radiologic procedure is a cost/benefit decision, and genetic risk is a part of the cost. Although cost is usually very low compared to benefit, if the procedure is unnecessary then the cost may be unacceptable. On the basis of current estimates, the doubling dose is assumed to be 40 rem (range 20 to 200) for an acute dose, and 100 rem for protracted exposure. Although there is no satisfactory way to predict the size of the risk for an individual exposed, any risk should be incentive to avoid unnecessary radiation to the gonads. Conception should be delayed for at least ten months for women and three or four months for men after irradiation of the gonads. The current incidence of genetically related diseases in the United States population is 60,000 per million live births. Based on the most conservative set of assumptions, an average gonadal dose of 1000 mrem to the whole population would increase the incidence of genetically related diseases by 0.2%

  1. Effects of high vs low-level radiation exposure

    International Nuclear Information System (INIS)

    In order to appreciate adequately the various possible effects of radiation, particularly from high-level vs low-level radiation exposure (HLRE, vs LLRE), it is necessary to understand the substantial differences between (a) exposure as used in exposure-incidence curves, which are always initially linear and without threshold, and (b) dose as used in dose-response curves, which always have a threshold, above which the function is curvilinear with increasing slope. The differences are discussed first in terms of generally familiar nonradiation situations involving dose vs exposure, and then specifically in terms of exposure to radiation, vs a dose of radiation. Examples are given of relevant biomedical findings illustrating that, while dose can be used with HLRE, it is inappropriate and misleading the LLRE where exposure is the conceptually correct measure of the amount of radiation involved

  2. Occupational Radiation Exposure During Endovascular Aortic Repair

    Energy Technology Data Exchange (ETDEWEB)

    Sailer, Anna M., E-mail: anni.sailer@mumc.nl [Maastricht University Medical Centre (MUMC), Department of Radiology (Netherlands); Schurink, Geert Willem H., E-mail: gwh.schurink@mumc.nl [Maastricht University Medical Centre (MUMC), Department of Surgery (Netherlands); Bol, Martine E., E-mail: m.bol@maastrichtuniversity.nl; Haan, Michiel W. de, E-mail: m.de.haan@mumc.nl; Zwam, Willem H. van, E-mail: w.van.zwam@mumc.nl; Wildberger, Joachim E., E-mail: j.wildberger@mumc.nl; Jeukens, Cécile R. L. P. N., E-mail: cecile.jeukens@mumc.nl [Maastricht University Medical Centre (MUMC), Department of Radiology (Netherlands)

    2015-08-15

    PurposeThe aim of the study was to evaluate the radiation exposure to operating room personnel and to assess determinants for high personal doses during endovascular aortic repair.Materials and MethodsOccupational radiation exposure was prospectively evaluated during 22 infra-renal aortic repair procedures (EVAR), 11 thoracic aortic repair procedures (TEVAR), and 11 fenestrated or branched aortic repair procedures (FEVAR). Real-time over-lead dosimeters attached to the left breast pocket measured personal doses for the first operators (FO) and second operators (SO), radiology technicians (RT), scrub nurses (SN), anesthesiologists (AN), and non-sterile nurses (NSN). Besides protective apron and thyroid collar, no additional radiation shielding was used. Procedural dose area product (DAP), iodinated contrast volume, fluoroscopy time, patient’s body weight, and C-arm angulation were documented.ResultsAverage procedural FO dose was significantly higher during FEVAR (0.34 ± 0.28 mSv) compared to EVAR (0.11 ± 0.21 mSv) and TEVAR (0.06 ± 0.05 mSv; p = 0.003). Average personnel doses were 0.17 ± 0.21 mSv (FO), 0.042 ± 0.045 mSv (SO), 0.019 ± 0.042 mSv (RT), 0.017 ± 0.031 mSv (SN), 0.006 ± 0.007 mSv (AN), and 0.004 ± 0.009 mSv (NSN). SO and AN doses were strongly correlated with FO dose (p = 0.003 and p < 0.001). There was a significant correlation between FO dose and procedural DAP (R = 0.69, p < 0.001), iodinated contrast volume (R = 0.67, p < 0.001) and left-anterior C-arm projections >60° (p = 0.02), and a weak correlation with fluoroscopy time (R = 0.40, p = 0.049).ConclusionAverage FO dose was a factor four higher than SO dose. Predictors for high personal doses are procedural DAP, iodinated contrast volume, and left-anterior C-arm projections greater than 60°.

  3. Information by the German Federal Government. Environmental radioactivity and radiation exposure in 2012

    International Nuclear Information System (INIS)

    The information by the German Federal Government on environmental radioactivity and radiation exposure in 2012 covers the following issues: Natural radiation exposure; radiation exposure due to civilization (nuclear power plants and nuclear facilities, radioactive waste storage, radioactive matter in research, engineering and medicine, nuclear accidents, nuclear weapon tests); occupational radiation exposure; medical radiation exposure; non-ionizing radiation.

  4. Chronic escalating cocaine exposure, abstinence/withdrawal, and chronic re-exposure: Effects on striatal dopamine and opioid systems in C57BL/6J mice

    OpenAIRE

    Yong ZHANG; Schlussman, Stefan D; Rabkin, Jacqui; Butelman, Eduardo R.; Ho, Ann; Kreek, Mary Jeanne

    2012-01-01

    Cocaine addiction is a chronic relapsing disease with periods of chronic escalating self-exposure, separated by periods of abstinence/withdrawal of varying duration. Few studies compare such cycles in preclinical models. This study models an “addiction-like cycle” in mice to determine neurochemical/molecular alterations that underlie the chronic, relapsing nature of this disease. Groups of male C57BL/6J mice received acute cocaine exposure (14-day saline/14-day withdrawal /13-day saline + 1-d...

  5. Radiation doses and possible radiation effects of low-level, chronic radiation in vegetation

    International Nuclear Information System (INIS)

    Measurements were made of radiation doses in soil and vegetation in Pu-contaminated areas at the Nevada Test Site with the objective of investigating low-level, low-energy gamma radiation (with some beta radiation) effects at the cytological or morphological level in native shrubs. In this preliminary investigation, the exposure doses to shrubs at the approximate height of stem apical meristems were estimated from 35 to 140 R for a ten-year period. The gamma exposure dose estimated for the same period was 20.7 percent +- 6.4 percent of that recorded by the dosimeters used in several kinds of field instrument surveys. Hence, a survey instrument reading made at about 25 cm in the tops of shrubs should indicate about 1/5 the dosimeter-measured exposures. No cytology has yet been undertaken because of the drought since last winter. (auth)

  6. Radiation exposure and radiation risk of the mammographic patient

    International Nuclear Information System (INIS)

    Depending on the technique applied the doses in the centre of the breast are significantly different. The dose reduction of a screen film grid combination is 50% compared with non-screen film. For the screen film combination alone it is significantly higher. The limited image quality of the gridless technique is not suited for primary examination. According to the present state of knowledge there are no reliable results about the radiation exposure of the breast in mammography and the induction of breast cancer. In a periodic mass screening the existing risk is significantly exceeded by the potential outcome. The care about the statistically calculated risk is irrelevant as to examinations within intervals of 1-2 years for women above 40. (author)

  7. Impacts of chronic sublethal exposure to clothianidin on winter honeybees.

    Science.gov (United States)

    Alkassab, Abdulrahim T; Kirchner, Wolfgang H

    2016-07-01

    A wide application of systemic pesticides and detection of their residues in bee-collected pollen and nectar at sublethal concentrations led to the emergence of concerns about bees' chronic exposure and possible sublethal effects on insect pollinators. Therefore, special attention was given to reducing unintentional intoxications under field conditions. The sensitivity of winter bees throughout their long lifespan to residual exposure of pesticides is not well known, since most previous studies only looked at the effects on summer bees. Here, we performed various laboratory bioassays to assess the effects of clothianidin on the survival and behavior of winter bees. Oral lethal and sublethal doses were administered throughout 12-day. The obtained LD50 values at 48, 72, 96 h and 10 days were 26.9, 18.0, 15.1 and 9.5 ng/bee, respectively. Concentrations <20 µg/kg were found to be sublethal. Oral exposure to sublethal doses was carried out for 12-day and, the behavioral functions were tested on the respective 13th day. Although slight reductions in the responses at the concentrations 10 and 15 µg/kg were observed, all tested sublethal concentrations had showed non-significant effects on the sucrose responsiveness, habitation of the proboscis extension reflex and olfactory learning performance. Nevertheless, chronic exposure to 15 µg/kg affected the specificity of the early long-term memory (24 h). Since the tested concentrations were in the range of field-relevant concentrations, our results strongly suggest that related-effects on winter and summer bees' sensitivity should also be studied under realistic conditions. PMID:27090425

  8. Effects of ionising radiation exposure on plants, fish and mammals: relevant data for environmental radiation protection

    International Nuclear Information System (INIS)

    In order to develop a framework for the assessment of the environmental impact of radiation, it is necessary to establish the relationship between exposure (dose rate, accumulated dose) and the effects that may be induced in plants and animals. With this purpose in mind, the data available on effects induced by ionising radiation in various wildlife groups have been reviewed as part of the FASSET project. This paper has highlighted that the available information on the effects of low dose rate, continuous irradiation (3 μGy h-1) is reasonable for plants, fish and mammals, but is scarce or non-existent for other wildlife groups. Thus, the effects induced in plants, fish and mammals after chronic exposure to radiation are presented in this paper. The fragmentary nature of the available, relevant information has made it very difficult to characterise the desired dose rate-response relationships in any detail. However, it can be broadly concluded that, although minor effects may be seen at lower dose rates in the most sensitive species and systems, the threshold for statistically significant effects in most studies is about 102 μGy h-1. The responses then increase progressively with increasing dose rate and usually become very clear at dose rates>103 μGy h-1 sustained for a large fraction of the lifespan

  9. Epistemological limitation for attributing health effects to natural radiation exposure

    International Nuclear Information System (INIS)

    The attribution of health effects to prolonged radiation exposure situations, such as those experienced in nature, is a challenging problem. The paper describes the epistemological limitations for such attribution it demonstrate that in most natural exposure situations, the theory of radiation-related sciences is not capable to provide the scientific evidence that health effects actually occur (or do not occur) and, therefore, that radiation effects are attributable to natural exposure situations and imputable to nature. Radiation exposure at high levels is known to provoke health effects as tissue reactions. If individuals experience these effects they can be attributed to the specific exposure with a high degree of confidence under the following conditions: the dose incurred have been higher that the relevant dose-threshold for the specific effect; and an unequivocal pathological diagnosis is attainable ensuring that possible competing causes have been eliminated. Only under these conditions, the occurrence of the effect may be properly attested and attributed to the exposure. However, even high levels of natural radiation exposure are lower than relevant dose-thresholds for tissue reactions and, therefore, natural radiation exposure is generally unable to cause these type of effects. One exception to this general rule could be situations of high levels of natural radiation exposure that might be sufficient to induce opacities in the lens of the eyes (which could be considered a tissue-reaction type of effect)

  10. Biological effects of low-dose ionizing radiation exposure

    International Nuclear Information System (INIS)

    The report on the meeting of the Strahlenschutzkommission 2007 concerning biological effects of low-dose ionizing radiation exposure includes the following contributions: Adaptive response. The importance of DNA damage mechanisms for the biological efficiency of low-energy photons. Radiation effects in mammography: the relative biological radiation effects of low-energy photons. Radiation-induced cataracts. Carcinomas following prenatal radiation exposure. Intercellular apoptosis induction and low-dose irradiation: possible consequences for the oncogenesis control. Mechanistic models for the carcinogenesis with radiation-induced cell inactivation: application to all solid tumors in the Japanese atomic bomb survivors. Microarrays at low radiation doses. Mouse models for the analysis of biological effects of low-dose ionizing radiation. The bystander effect: observations, mechanisms and implications. Lung carcinoma risk of Majak workers - modeling of carcinogenesis and the bystander effect. Microbeam studies in radiation biology - an overview. Carcinogenesis models with radiation-induced genomic instability. Application to two epidemiological cohorts.

  11. Acute and Chronic Cutaneous Reactions to Ionizing Radiation Therapy

    OpenAIRE

    Bray, Fleta N.; Simmons, Brian J.; Aaron H. Wolfson; Nouri, Keyvan

    2016-01-01

    Ionizing radiation is an important treatment modality for a variety of malignant conditions. However, development of radiation-induced skin changes is a significant adverse effect of radiation therapy (RT). Cutaneous repercussions of RT vary considerably in severity, course, and prognosis. When they do occur, cutaneous changes to RT are commonly graded as acute, consequential-late, or chronic. Acute reactions can have severe sequelae that impact quality of life as well as cancer treatment. Th...

  12. Radiation exposure of nurses in a coronary care unit

    International Nuclear Information System (INIS)

    In response to increasing awareness of radiation as a possible occupational hazard, nursing personnel staffing a hospital CCU were monitored over a 3-year period to determine occupational exposure. Portable x-ray machines, fluoroscopic units, and patients injected with radiopharmaceuticals were all potential radiation sources on such a unit. Whole-body TLD badges, exchanged monthly, indicated no cumulative exposures over 80 mR during the entire study period. The minimal exposures reported do not justify regular use of dosimeters. Adherence to standard protective measures precludes most exposure to machine-produced radiation. Close, prolonged contact with a patient after an RVG study that utilizes /sup 99m/Tc may account for some exposure. The data indicate that radiation is not a significant occupational hazard for CCU nurses at this hospital; similar minimal exposures would be expected of other nonoccupationally exposed nursing personnel in like environments

  13. The effects of internal radiation exposure on cancer mortality in nuclear workers at Rocketdyne/Atomics International.

    OpenAIRE

    Ritz, B.; Morgenstern, H; Crawford-Brown, D; Young, B.

    2000-01-01

    We examined the effects of chronic exposure to radionuclides, primarily uranium and mixed-fission products, on cancer mortality in a retrospective cohort study of workers enrolled in the radiation-monitoring program of a nuclear research and development facility. Between 1950 and 1994, 2,297 workers were monitored for internal radiation exposures, and 441 workers died, 134 (30.4%) of them from cancer as the underlying cause. We calculated internal lung-dose estimates based on urinalysis and w...

  14. DOE occupational radiation exposure. Report 1992--1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-05-01

    The DOE Occupational Radiation Exposure Report, 1992-1994 reports occupational radiation exposures incurred by individuals at US Department of Energy (DOE) facilities from 1992 through 1994. This report includes occupational radiation exposure information for all DOE employees, contractors, subcontractors, and visitors. This information is analyzed and trended over time to provide a measure of the DOE`s performance in protecting its workers from radiation. Occupational radiation exposure at DOE has been decreasing over the past 5 years. In particular, doses in the higher dose ranges are decreasing, including the number of doses in excess of the DOE limits and doses in excess of the 2 rem Administrative Control Level (ACL). This is an indication of greater attention being given to protecting these individuals from radiation in the workplace.

  15. DOE occupational radiation exposure. Report 1992--1994

    International Nuclear Information System (INIS)

    The DOE Occupational Radiation Exposure Report, 1992-1994 reports occupational radiation exposures incurred by individuals at US Department of Energy (DOE) facilities from 1992 through 1994. This report includes occupational radiation exposure information for all DOE employees, contractors, subcontractors, and visitors. This information is analyzed and trended over time to provide a measure of the DOE's performance in protecting its workers from radiation. Occupational radiation exposure at DOE has been decreasing over the past 5 years. In particular, doses in the higher dose ranges are decreasing, including the number of doses in excess of the DOE limits and doses in excess of the 2 rem Administrative Control Level (ACL). This is an indication of greater attention being given to protecting these individuals from radiation in the workplace

  16. Radiation exposure in I-131 iodine therapy

    International Nuclear Information System (INIS)

    In the past five years, the applied I-131 radioactivity quantity has doubled with a constant number of beds. In 1984, it was 925 GBq (25 Ci). Despite this development, no changes in the professional radiation exposure were made out. The evaluation shows a dose smaller than 0.04 man Sv/TBq (0.16 man rem/Ci) of I-131 applied. This value is below the traceability limit of the film badges. The incorporation load of the personnel (27 members) was determined by monthly body counter measurements. Only in one measurement thyroid gland activity of 5 kBq (140 nCi) was detected. Most measurements did not show any incorporation; and the few positive results were below 0.74 kBq (20 nCi). The environmental load due to unfiltered release from patients' rooms was determined at the fence of the nuclear research plant. The maximum was 0.24 mSv/a thyroid gland dose of a small child in 1982 taking into account the measured 90% partion of organic compound iodine. The waste water is decayed following chemical treatment in storage tanks. (orig./HP)

  17. Radiation exposure: Cytogenetic tests. Chernobyl reactor accident

    International Nuclear Information System (INIS)

    Forty test subjects who, either during or after the reactor accident of Chernobyl (26th April 1986), stayed at a building site at Shlobin 150 km away, were examined for spontaneously occurring as well as mitomycin C-induced Sister Chromatid Exchanges (SCE). The building site staff, who underwent a whole-body radionuclide count upon their return to Austria (June through September 1986), were used for the cytogenetic tests. The demonstration of the SCE was made from whole-blood cultures by the fluorescence/Giemse technique. At last 20 Metaphases of the 2nd mitotic cycle were evaluated per person. The radiation doses of the test subjects were calculated by adding the external exposure determined on the building site, the estimated thyroid dose through I-131, and the measured incorporation of Cs-134 and Cs-137. The subjects were divided into two groups for statistical analysis: One was a more exposed group (proven stay at Shlobin between 26th April and 31st May 1986, mostly working in the open air) and the other a less exposed group for comparison (staying at Shlobin from 1st Juni 1986 and working mainly indoors). (orig.)

  18. Maintenance hemodialysis patients have high cumulative radiation exposure.

    LENUS (Irish Health Repository)

    Kinsella, Sinead M

    2010-10-01

    Hemodialysis is associated with an increased risk of neoplasms which may result, at least in part, from exposure to ionizing radiation associated with frequent radiographic procedures. In order to estimate the average radiation exposure of those on hemodialysis, we conducted a retrospective study of 100 patients in a university-based dialysis unit followed for a median of 3.4 years. The number and type of radiological procedures were obtained from a central radiology database, and the cumulative effective radiation dose was calculated using standardized, procedure-specific radiation levels. The median annual radiation dose was 6.9 millisieverts (mSv) per patient-year. However, 14 patients had an annual cumulative effective radiation dose over 20 mSv, the upper averaged annual limit for occupational exposure. The median total cumulative effective radiation dose per patient over the study period was 21.7 mSv, in which 13 patients had a total cumulative effective radiation dose over 75 mSv, a value reported to be associated with a 7% increased risk of cancer-related mortality. Two-thirds of the total cumulative effective radiation dose was due to CT scanning. The average radiation exposure was significantly associated with the cause of end-stage renal disease, history of ischemic heart disease, transplant waitlist status, number of in-patient hospital days over follow-up, and death during the study period. These results highlight the substantial exposure to ionizing radiation in hemodialysis patients.

  19. Chronic escalating cocaine exposure, abstinence/withdrawal, and chronic re-exposure: effects on striatal dopamine and opioid systems in C57BL/6J mice.

    Science.gov (United States)

    Zhang, Yong; Schlussman, Stefan D; Rabkin, Jacqui; Butelman, Eduardo R; Ho, Ann; Kreek, Mary Jeanne

    2013-04-01

    Cocaine addiction is a chronic relapsing disease with periods of chronic escalating self-exposure, separated by periods of abstinence/withdrawal of varying duration. Few studies compare such cycles in preclinical models. This study models an "addiction-like cycle" in mice to determine neurochemical/molecular alterations that underlie the chronic, relapsing nature of this disease. Groups of male C57BL/6J mice received acute cocaine exposure (14-day saline/14-day withdrawal/13-day saline + 1-day cocaine), chronic cocaine exposure (14 day cocaine) or chronic re-exposure (14-day cocaine/14-day withdrawal/14-day cocaine). Escalating-dose binge cocaine (15-30 mg/kg/injection × 3/day, i.p. at hourly intervals) or saline (14-day saline) was administered, modeling initial exposure. In "re-exposure" groups, after a 14-day injection-free period (modeling abstinence/withdrawal), mice that had received cocaine were re-injected with 14-day escalating-dose binge cocaine, whereas controls received saline. Microdialysis was conducted on the 14th day of exposure or re-exposure to determine striatal dopamine content. Messenger RNA levels of preprodynorphin (Pdyn), dopamine D1 (Drd1) and D2 (Drd2) in the caudate putamen were determined by real-time PCR. Basal striatal dopamine levels were lower in mice after 14-day escalating exposure or re-exposure than in those in the acute cocaine group and controls. Pdyn mRNA levels were higher in the cocaine groups than in controls. Long-term adaptation was observed across the stages of this addiction-like cycle, in that the effects of cocaine on dopamine levels were increased after re-exposure compared to exposure. Changes in striatal dopaminergic responses across chronic escalating cocaine exposure and re-exposure are a central feature of the neurobiology of relapsing addictive states. PMID:23164614

  20. Radiation exposure from medical field in France

    International Nuclear Information System (INIS)

    Full text of publication follows: The only nationwide survey on medical X-ray practices in France was carried out more than fifteen years ago and recent updated information about the nature and frequency of X-ray diagnostic procedures and associated doses is lacking. However, with the implementation of the European Directive 97/43, the knowledge of medical practices is necessary and the question of the population dose resulting from medical X-ray examinations is raised again. In order to provide French data concerning the medical exposure to ionizing radiation, the Institute for Radiation Protection and Nuclear Safety (I.R.S.N.) and the National Institute for Public Health Surveillance (I.n.V.S.) have created an observatory of medical exposure to ionizing radiation. A first study was carried out in order to evaluate the nature and frequency of X-ray diagnostic procedures in conventional radiology and computed tomography. Information about annual frequencies was collected from two main sources: the main health insurance company (C.N.A.M.-T.S. - private radiologists) and the national statistics of the health establishments (S.A.E. examinations realized in public and private hospitals) from the ministry of health. Relevant data concerning examinations in conventional radiology (C.R.) with dental radiology and computed tomography (CT) were collected for the year 2002. As these two main sources of data may overlap, two hypotheses were retained, named low hypothesis (l.h.) and high hypothesis (h.h.). Dose contribution of these exams per inhabitant was calculated from French values of dose from the diagnostic reference level (D.R.L.) campaign completed with data from the European Commission publication 118 and from the health protection agency (H.P.A.). In this study, 82 different examination types were identified for C.R., according to the new French nomenclature for medical examinations (C.C.A.M.). The first five examinations (in number) are respectively chest

  1. DOE Basic Overview of Occupational Radiation Exposure_2011 pamphlet

    Energy Technology Data Exchange (ETDEWEB)

    ORAU

    2012-08-08

    This pamphlet focusses on two HSS activities that help ensure radiation exposures are accurately assessed and recorded, namely: 1) the quality and accuracy of occupational radiation exposure monitoring, and 2) the recording, reporting, analysis, and dissemination of the monitoring results. It is intended to provide a short summary of two specific HSS programs that aid in the oversight of radiation protection activities at DOE. The Department of Energy Laboratory Accreditation Program (DOELAP) is in place to ensure that radiation exposure monitoring at all DOE sites is precise and accurate, and conforms to national and international performance and quality assurance standards. The DOE Radiation Exposure Monitoring Systems (REMS) program provides for the collection, analysis, and dissemination of occupational radiation exposure information. The annual REMS report is a valuable tool for managing radiological safety programs and for developing policies to protect individuals from occupational exposure to radiation. In tandem, these programs provide DOE management and workers an assurance that occupational radiation exposures are accurately measured, analyzed, and reported.

  2. Radiation exposure in gastroenterology: improving patient and staff protection.

    LENUS (Irish Health Repository)

    Ho, Immanuel K H

    2014-08-01

    Medical imaging involving the use of ionizing radiation has brought enormous benefits to society and patients. In the past several decades, exposure to medical radiation has increased markedly, driven primarily by the use of computed tomography. Ionizing radiation has been linked to carcinogenesis. Whether low-dose medical radiation exposure will result in the development of malignancy is uncertain. This paper reviews the current evidence for such risk, and aims to inform the gastroenterologist of dosages of radiation associated with commonly ordered procedures and diagnostic tests in clinical practice. The use of medical radiation must always be justified and must enable patients to be exposed at the lowest reasonable dose. Recommendations provided herein for minimizing radiation exposure are based on currently available evidence and Working Party expert consensus.

  3. The treatment progress of radiation dermatitis from external exposure

    International Nuclear Information System (INIS)

    Radiation dermatitis is often seen and is often a complication of radiation therapy of tumors. It is characterized by poor healing, stubborn relapse, and carcinogenesis.. The treatment include drug, physical therapy and surgery. This article describes the treatment progress of radiation dermatitis from external exposure. (authors)

  4. Observations of nesting avifauna under gamma-radiation exposure

    International Nuclear Information System (INIS)

    An opportunity arose to observe the nesting success of birds (up to the time of fledging) when the Enterprise Forest Radiation Facility was established for a study of the effects of gamma radiation on the flora and fauna of northern forest communities. The results of these observations on the fate of the nest occupants in relation to radiation exposure are presented

  5. Acute and Chronic Cutaneous Reactions to Ionizing Radiation Therapy.

    Science.gov (United States)

    Bray, Fleta N; Simmons, Brian J; Wolfson, Aaron H; Nouri, Keyvan

    2016-06-01

    Ionizing radiation is an important treatment modality for a variety of malignant conditions. However, development of radiation-induced skin changes is a significant adverse effect of radiation therapy (RT). Cutaneous repercussions of RT vary considerably in severity, course, and prognosis. When they do occur, cutaneous changes to RT are commonly graded as acute, consequential-late, or chronic. Acute reactions can have severe sequelae that impact quality of life as well as cancer treatment. Thus, dermatologists should be informed about these adverse reactions, know how to assess their severity and be able to determine course of management. The majority of measures currently available to prevent these acute reactions are proper skin hygiene and topical steroids, which limit the severity and decrease symptoms. Once acute cutaneous reactions develop, they are treated according to their severity. Treatments are similar to those used in prevention, but incorporate wound care management that maintains a moist environment to hasten recovery. Chronic changes are a unique subset of adverse reactions to RT that may develop months to years following treatment. Chronic radiation dermatitis is often permanent, progressive, and potentially irreversible with substantial impact on quality of life. Here, we also review the etiology, clinical manifestations, pathogenesis, prevention, and management of late-stage cutaneous reactions to radiotherapy, including chronic radiation dermatitis and radiation-induced fibrosis. PMID:27250839

  6. Criteria for radiological protection against exposure to natural radiation

    International Nuclear Information System (INIS)

    Ionizing radiation includes natural radiation which has been part cosmic radiation. Radon in homes, irradiation, gamma, among others, they have also been part of ionizing radiation. The activities that have lead to natural radiation materials are: mining and processing of uranium, radio application and thorium, phosphate industry, mining and smelting of metals, oil and gas extraction, coal mining and power generation, rare earth industry and titanium, zirconium and ceramics, building materials, waste water purification. Therefore, different criteria for radiation protection have had to create against exposure to natural radiation. Distinct rules and regulations to control were created in that sense

  7. Prenatal radiation exposure. Conclusions in the light of radiology

    International Nuclear Information System (INIS)

    Within 6 years of the appearance of the guideline for action to be taken by doctors in the event of prenatal exposure to radiation, intended as a proposal for discussion, the following has turned out: in no case has termination of pregnancy become necessary following prenatal radiation exposure, prenatal radiation exposure was always low (about 20 mSv), there is no risk below respective threshold doses, teratogenesis is a non-stochastic process, which is why risk assessment was modified, the sensitivity of the human fetus to radiation is highest during the period of neuroblast development (9th to 16th week p.c.), and knowledge about an existing pregnancy can be taken for granted by that time, so radiation exposure is calculable and can be restricted to negligible quantities. (TRV)

  8. Variation of space radiation exposure inside spherical and hemispherical geometries

    International Nuclear Information System (INIS)

    We calculate the space radiation exposure to blood-forming organs everywhere inside a hemispherical dome that represents a lunar habitat. We derive the analytical pathlength distribution from any point inside a hemispherical or a spherical shell. Because the average pathlength increases with the distance from the center, the center of the hemispherical dome on the lunar surface has the largest radiation exposure while locations on the inner surface of the dome have the lowest exposure. This conclusion differs from an earlier study on a hemispherical dome but agrees with another earlier study on a spherical-shell shield. We also find that the reduction in the radiation exposure from the center to the inner edge of the dome can be as large as a factor of 3 or more for the radiation from solar particle events while being smaller for the radiation from galactic cosmic rays.

  9. Regulation of nuclear radiation exposures in India

    International Nuclear Information System (INIS)

    India has a long-term program of wide spread applications of nuclear radiations and radioactive sources for peaceful applications in medicine, industry, agriculture and research and is already having several thousand places in the country where such sources are being routinely used. These places are mostly outside the Department of Atomic Energy (DAE) installations. DAE supplies such sources. The most important application of nuclear energy in DAE is in electricity generation through nuclear power plants. Fourteen such plants are operating and many new plants are at various stages of construction. In view of the above mentioned wide spread applications, Indian parliament through an Act, called Atomic Energy Act, 1964 created an autonomous body called Atomic Energy Regulatory Board (AERB) with comprehensive authority and powers. This Board issues codes, guides, manuals, etc., to regulate such installations so as to ensure safe use of such sources and personnel engaged in such installations and environment receives radiation exposures within the upper bounds prescribed by them. Periodic reports are submitted to AERB to demonstrate compliance of its directives. Health, Safety and Environment Group of Bhabha Atomic Research Centres, Mumbai carries out necessary surveillance and monitoring of all installations of the DAE on a routine basis and also periodic inspections of other installations using radiation sources. Some of the nuclear fuel cycle plants like nuclear power plants and fuel reprocessing involve large radioactive source inventories and have potential of accidental release of radio activity into the environment, an Environmental Surveillance Laboratory (ESL) is set up at each such site much before the facility goes into operation. These ESL's collect baseline data and monitor the environment throughout the life of the facilities including the de- commissioning stage. The data is provided to AERB and is available to members of the public. In addition, a multi

  10. Radiation exposure due to nuclear power

    International Nuclear Information System (INIS)

    This information brochure contains 12 earlier papers of leading experts on the radiation hazard the population incurs during normal operation of nuclear facilities and the radiation-biological fundamentals of the effects of ionizing radio humans. (HP)

  11. DOE 2010 Occupational Radiation Exposure November 2011

    Energy Technology Data Exchange (ETDEWEB)

    U.S. Department of Energy, Office of Health, Safety and Security, Office of Analysis

    2011-11-11

    This report discusses radiation protection and dose reporting requirements, presents the 2010 occupational radiation dose data trended over the past 5 years, and includes instructions to submit successful ALARA projects.

  12. Gene expression as a biomarker for human radiation exposure.

    Science.gov (United States)

    Omaruddin, Romaica A; Roland, Thomas A; Wallace, H James; Chaudhry, M Ahmad

    2013-03-01

    Accidental exposure to ionizing radiation can be unforeseen, rapid, and devastating. The detonation of a radiological device leading to such an exposure can be detrimental to the exposed population. The radiation-induced damage may manifest as acute effects that can be detected clinically or may be more subtle effects that can lead to long-term radiation-induced abnormalities. Accurate identification of the individuals exposed to radiation is challenging. The availability of a rapid and effective screening test that could be used as a biomarker of radiation exposure detection is mandatory. We tested the suitability of alterations in gene expression to serve as a biomarker of human radiation exposure. To develop a useful gene expression biomonitor, however, gene expression changes occurring in response to irradiation in vivo must be measured directly. Patients undergoing radiation therapy provide a suitable test population for this purpose. We examined the expression of CC3, MADH7, and SEC PRO in blood samples of these patients before and after radiotherapy to measure the in vivo response. The gene expression after ionizing radiation treatment varied among different patients, suggesting the complexity of the response. The expression of the SEC PRO gene was repressed in most of the patients. The MADH7 gene was found to be upregulated in most of the subjects and could serve as a molecular marker of radiation exposure. PMID:23446844

  13. Exposure to ultraviolet radiation: recommendations for cosmetic use

    International Nuclear Information System (INIS)

    The beginning of the so-called tanning industry made possible the acquisition of a tanned skin independently of the available solar radiation. The tan is produced by ultraviolet radiation and, as well as in solar exposure, there are additional risks on the use of the so-called sun-beds. The damaging effects of ultraviolet exposure are well documented and reasonably quantified. The objective of this paper is to inform the potential effects of ultraviolet radiation exposure in sun-beds and to provide recommendations in order to reduce the associated risks. These recommendations are adapted for cosmetics use only (author)

  14. The Relationship between Ultraviolet Radiation Exposure and Vitamin D Status

    Directory of Open Access Journals (Sweden)

    Ola Engelsen

    2010-05-01

    Full Text Available This paper reviews the main factors influencing the synthesis of vitamin D, with particular focus on ultraviolet radiation exposure. On the global level, the main source of vitamin D is the sun. The effect of solar radiation on vitamin D synthesis depends to some extent on the initial vitamin D levels. At moderate to high latitudes, diet becomes an increasingly important source of vitamin D due to decreased solar intensity and cold temperatures, which discourage skin exposure. During the mid-winter season, these factors result in decreased solar radiation exposure, hindering extensively the synthesis of vitamin D in these populations.

  15. Proliferation ability of bone marrow cells of human in late periods after chronic radiation influence

    International Nuclear Information System (INIS)

    The ionizing radiation influence on human causes damage of hemopoiesis, that is one of the most radio-sensitive systems. Long-term chronic exposure leads quickly to changing the peripheral blood content, and therefore cytopenia (leucopenia and thrombocytopenia) of different degrees of its expressions depending from the value of exposure doses is being observed. The picture of peripheral blood and bone marrow has been fully studied in period of exposure and in period after the radiation influence end, when the gradual recovery of blood indexes was occurring to level that was observed during primary examination. The initial thrombocyte level recovered by 5th year of observation, but the leukocyte level recovery occurred later, and approached to the initial indexes in exposed persons by only 10th year. Despite the long-term period after the exposure end (25-30 years), the persons exposed to chronic γ-radiation doses, which exceeded the maximum permissible dose more that at 10 times, had the leukopenia, and in some cases the hypoplastic state of hemopoietic. (author)

  16. Hazards of radiation exposure for pregnant women

    International Nuclear Information System (INIS)

    Levels of radiation pregnant women may receive are discussed and a table is presented to show radiation doses for a number of common procedures. Radioinduced congenital anomalies and carcinogenesis are discussed with regard to dose-effect realationships. Although there is no level of radiation that does not have some probability of causing a mutation, the genetic risk to any one person is small. Practical guidelines for exposing pregnant women to radiation are presented

  17. Memory Deficit Recovery after Chronic Vanadium Exposure in Mice

    Directory of Open Access Journals (Sweden)

    Oluwabusayo Folarin

    2016-01-01

    Full Text Available Vanadium is a transitional metal with an ability to generate reactive oxygen species in the biological system. This work was designed to assess memory deficits in mice chronically exposed to vanadium. A total of 132 male BALB/c mice (4 weeks old were used for the experiment and were divided into three major groups of vanadium treated, matched controls, and animals exposed to vanadium for three months and thereafter vanadium was withdrawn. Animals were tested using Morris water maze and forelimb grip test at 3, 6, 9, and 12 months of age. The results showed that animals across the groups showed no difference in learning but had significant loss in memory abilities after 3 months of vanadium exposure and this trend continued in all vanadium-exposed groups relative to the controls. Animals exposed to vanadium for three months recovered significantly only 9 months after vanadium withdrawal. There was no significant difference in latency to fall in the forelimb grip test between vanadium-exposed groups and the controls in all age groups. In conclusion, we have shown that chronic administration of vanadium in mice leads to memory deficit which is reversible but only after a long period of vanadium withdrawal.

  18. Gene Expression Profiling of Biological Pathway Alterations by Radiation Exposure

    OpenAIRE

    Lee, Kuei-Fang; Weng, Julia Tzu-Ya; Hsu, Paul Wei-Che; Chi, Yu-Hsiang; Chen, Ching-Kai; Liu, Ingrid Y.; CHEN, YI-CHENG; Wu, Lawrence Shih-Hsin

    2014-01-01

    Though damage caused by radiation has been the focus of rigorous research, the mechanisms through which radiation exerts harmful effects on cells are complex and not well-understood. In particular, the influence of low dose radiation exposure on the regulation of genes and pathways remains unclear. In an attempt to investigate the molecular alterations induced by varying doses of radiation, a genome-wide expression analysis was conducted. Peripheral blood mononuclear cells were collected from...

  19. Retrospective ESR dosimetry for persons chronically exposed to ionizing radiation

    International Nuclear Information System (INIS)

    Objective: To establish an electron spin resonance (ESR) method to estimate the dose of persons chronically exposed to ionizing radiation. Methods: ESR method was used to detect the ESR signal intensities of tooth enamel samples from two persons chronically exposed to ionizing radiation. The external calibration curve method and the additive dose method were used to reconstruct the irradiation doses of those teeth in order to find whether it is feasible to estimate the chronic dose by enamel ESR. And the effects of radiation energy on the ESR signal intensities were also observed. Results: The estimated doses of two teeth from each person were similar using two methods. Compared 1.25 MeV with 6 MeV X rays, the regression coefficients of the calibration curve were similar, and the doses estimated after combined irradiation were the same as the actually exposed doses. Conclusion: Reconstruction of dose for persons chronically exposed to radiation can be achieved using tooth enamel ESR measurement. The radiation energy, between 1.25 MeV and 6 MeV has little effect on tooth enamel ESR measurement

  20. Taste aversions conditioned with partial body radiation exposures

    International Nuclear Information System (INIS)

    Radiation-induced taste aversion was compared in rats which received partial body exposure to the head or abdomen with rats receiving whole body irradiation. Exposure levels ranged from 25 to 300 roentgens (R). In additional groups, saccharin aversion to partial body gamma ray exposures of the abdomen were conditioned in animals which had prior experience with the saccharin solution. Aversion was measured with a single-bottle short-term test, a 23-hour preference test and by the number of days taken to recover from the aversion. Whole-body exposure was most effective in conditioning the aversion, and exposure of the abdominal area was more effective than exposure to the head. Also, the higher the exposure, the stronger the aversion. Rats receiving prior experience with the saccharin did not condition as well as control rats with no prior saccharin experience. The possible role of radiation-induced taste aversion in human radiotherapy patients was discussed. (author)

  1. Reducing medical exposure to ionizing radiation

    International Nuclear Information System (INIS)

    The author discusses the dangers of indiscriminate and uninformed use of medical x-ray facilities. He points out a lack of effective standards, controls, and practices to minimize exposures to x ray and to prevent the excessive use of diagnostic x-ray examinations. A list of practices whereby an individual can minimize his possible exposures to x rays is presented. Several approaches to the question of acceptable exposure levels are considered. (U.S.)

  2. radiation exposure at work places caused by natural radionuclides

    International Nuclear Information System (INIS)

    The new Euratom basic standards for radiological protection (guideline 96/29/Euratom of the Council of 13 May 1996 on the Determination of Basic Safety Standards for the protection of Health of Staff and Population against the Dangers by Ionizing radiation) contain in section 2 of the Title VII, which deals with exposure by natural radiation sources, a request to by the EC member states to determine by investigations or other appropriate means the work places which are of importance with regard to natural radiation exposure. Against the background of the implementation of these new Euratom basic standards, a work group named, radiation Exposure at Work Places by Natural Radionuclides was founded in November 1994 by the German Commission on Radiological protection. This working group was supposed to determine the possible exposure pathways by natural radiation, the extent of radiation exposure at work places for these exposure pathways, and the number of employed persons affected by the different exposure pathways and to compile the gained information in a survey. The following report gives a comprehensive survey on the results of these investigations and their relevance to radiological protection. (author)

  3. Chronic neuroendocrinological sequelae of radiation therapy

    Energy Technology Data Exchange (ETDEWEB)

    Sklar, C.A. [Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Constine, L.S. [Univ. of Rochester Medical Center, Rochester, NY (United States)

    1995-03-30

    A variety of neuroendocrine disturbances are observed following treatment with external radiation therapy when the hypothalamic-pituitary axis (HPA) is included in the treatment field. Radiation-induced abnormalities are generally dose dependent and may develop many years after irradiation. Growth hormone deficiency and premature sexual development can occur following doses as low as 18 Gy fractionated radiation and are the most common neuroendocrine problems noted in children. Deficiency of gonadotropins, thyroid stimulating hormone, and adrenocorticotropin are seen primarily in individuals treated with > 40 Gy HPA irradiation. Hyperprolactinemia can be seen following high-dose radiotherapy (>40 Gy), especially among young women. Most neuroendocrine disturbances that develop as a result of HPA irradiation are treatable; patients at risk require long-term endocrine follow-up. 23 refs., 6 figs., 2 tabs.

  4. Chronic neuroendocrinological sequelae of radiation therapy

    International Nuclear Information System (INIS)

    A variety of neuroendocrine disturbances are observed following treatment with external radiation therapy when the hypothalamic-pituitary axis (HPA) is included in the treatment field. Radiation-induced abnormalities are generally dose dependent and may develop many years after irradiation. Growth hormone deficiency and premature sexual development can occur following doses as low as 18 Gy fractionated radiation and are the most common neuroendocrine problems noted in children. Deficiency of gonadotropins, thyroid stimulating hormone, and adrenocorticotropin are seen primarily in individuals treated with > 40 Gy HPA irradiation. Hyperprolactinemia can be seen following high-dose radiotherapy (> 40 Gy), especially among young women. Most neuroendocrine disturbances that develop as a result of HPA irradiation are treatable; patients at risk require long-term endocrine follow-up

  5. An Overview of NASA's Risk of Cardiovascular Disease from Radiation Exposure

    Science.gov (United States)

    Patel, Zarana S.; Huff, Janice L.; Simonsen, Lisa C.

    2015-01-01

    The association between high doses of radiation exposure and cardiovascular damage is well established. Patients that have undergone radiotherapy for primary cancers of the head and neck and mediastinal regions have shown increased risk of heart and vascular damage and long-term development of radiation-induced heart disease [1]. In addition, recent meta-analyses of epidemiological data from atomic bomb survivors and nuclear industry workers has also shown that acute and chronic radiation exposures is strongly correlated with an increased risk of circulatory disease at doses above 0.5 Sv [2]. However, these analyses are confounded for lower doses by lifestyle factors, such as drinking, smoking, and obesity. The types of radiation found in the space environment are significantly more damaging than those found on Earth and include galactic cosmic radiation (GCR), solar particle events (SPEs), and trapped protons and electrons. In addition to the low-LET data, only a few studies have examined the effects of heavy ion radiation on atherosclerosis, and at lower, space-relevant doses, the association between exposure and cardiovascular pathology is more varied and unclear. Understanding the qualitative differences in biological responses produced by GCR compared to Earth-based radiation is a major focus of space radiation research and is imperative for accurate risk assessment for long duration space missions. Other knowledge gaps for the risk of radiation-induced cardiovascular disease include the existence of a dose threshold, low dose rate effects, and potential synergies with other spaceflight stressors. The Space Radiation Program Element within NASA's Human Research Program (HRP) is managing the research and risk mitigation strategies for these knowledge gaps. In this presentation, we will review the evidence and present an overview of the HRP Risk of Cardiovascular Disease and Other Degenerative Tissue Effects from Radiation Exposure.

  6. ACREM: A new air crew radiation exposure measuring system

    International Nuclear Information System (INIS)

    Cosmic radiation has already been discovered in 1912 by the Austrian Nobel Laureate Victor F. Hess. After Hess up to now numerous measurements of the radiation exposure by cosmic rays in different altitudes have been performed, however, this has not been taken serious in view of radiation protection.Today, with the fast development of modern airplanes, an ever increasing number of civil aircraft is flying in increasing altitudes for considerable time. Members of civil aircrew spending up to 1000 hours per year in cruising altitudes and therefore are subject to significant levels of radiation exposure. In 1990 ICRP published its report ICRP 60 with updated excess cancer risk estimates, which led to significantly higher risk coefficients for some radiation qualities. An increase of the radiation weighting factors for mean energy neutron radiation increases the contribution for the neutron component to the equivalent dose by about 60%, as compared to the earlier values of ICRP26. This higher risk coefficients lead to the recommendation of the ICRP, that cosmic radiation exposure in civil aviation should be taken into account as occupational exposure. Numerous recent exposure measurements at civil airliners in Germany, Sweden, USA, and Russia show exposure levels in the range of 3-10 mSv/year. This is significantly more than the average annual dose of radiation workers (in Austria about 1.5 mSv/year). Up to now no practicable and economic radiation monitoring system for routine application on board exits. A fairly simple and economic approach to a practical, active in-flight dosimeter for the assessment of individual crew exposure is discussed in this paper

  7. A model of hemo-immunopoietic system adaptation to chronic low and intermediate radiation doses

    International Nuclear Information System (INIS)

    In this paper radiobiological conformities to natural laws of mice's hemoimmunopoiesis systems (lines CBA and C57 Bl/6) were investigated upon chronic internal with lowering power doses of β- irradiation 90Sr and external γ-irradiation with constant power. It was shown that determinative effects of long chronic irradiation become apparent upon development of chronic radioactive effect for experimental animals were observed upon γ-irradiation with power 6 cGy/day and more or under internal with lowering power dose of β-irradiation 90Sr introduced in concentration above 1.1 c Bq/g, that is correlated with appreciations of other author's made before, concerning 'critical' level of power doses for hemopoietic system. It was shown that reduction of medium length of animals' life correlates with dis-balance into a system and between systems' links of immuno- and hemopoiesis. Physiological balance of those systems was supplied genetically by determinative systems of sanogenesis, responded for forming adaptive processes in organism. Characteristics of positive and negative inter and outward systems' links, induced by additional radiation exposure and noticeably modified constitutive regulative mechanisms being before were made more exact. A model for adaptation of hemoimmunopoiesis system to chronic radiation exposure in a rate of low and intermediate power doses was modeled. A possibility of full or part regeneration of hemopoiesis depending on power dose and kind of irradiation was experimentally substantiated. (author)

  8. Correlation between natural radiation exposure and cancer mortality, (4)

    International Nuclear Information System (INIS)

    In the previous studies, using Pearson's product moment correlation coefficient, we found that in most cases of cancers, statistically significant positive correlations were observed between natural background radiation exposure rate and crude cancer mortality rate over the period 1950 - 1978. Furthermore, we found that the statistical significance of correlation between natural background radiation exposure rate and the age-adjusted cancer mortality rate in the same period mostly disappeared. We studied the cause of this apparent correlation and found that the prefecture with a higher natural background radiation exposure rate had a greater component ratio of older people. In Japan, a number of prefectures with a higher natural background exposure rate are located in relatively thinly populated districts which have been experiencing an outflow of the younger generation to more highly industrialized and urbanized areas. Therefore, statistically significant positive correlations were observed for almost all cancers between natural background radiation exposure rate and crude cancer mortality rate. In the present investigation, we statistically tested the frequency distributions of natural background radiation exposure rate and age-adjusted cancer mortality rate, and calculated Spearman's rank correlation coefficient between natural background radiation exposure rate and the age-adjusted cancer mortality rate. The frequency distribution of the natural background radiation exposure rate and that of the age-adjusted mortality rate appeared normal in most cases of cancer, and the statistical significance of correlation between natural background exposure rate and the age-adjusted cancer mortality rate did not differ much on the whole, even though we used Spearman's rank correlation coefficient between them. (author)

  9. Protection from potential exposures: application to selected radiation sources

    International Nuclear Information System (INIS)

    This ICRP Report begins with the general principles of radiation protection in the case of potential exposures, followed by special issues in application and compliance with regulatory aims. The rest of the report uses event trees or fault trees to derive the logical structure of six scenarios of potential exposure, i.e. two irradiators, a large research accelerator, an accelerator for industrial isotope production, an industrial radiography device using a mobile source of radiation, and finally a medical gamma radiotherapy device. (UK)

  10. ''Notifiable events'': Only small impact on the radiation exposure

    International Nuclear Information System (INIS)

    In 1994, a total of 50 ''notifable events'' in the handling or transport of radioactive materials were reported to the BMU. The article presents a survey of the causes of these events in Germany and an analysis of their effects with regard to exceptional radiation exposure. The data given show that at least in the reporting year the notifiable events contributed an only very small share to the overall occupational radiation exposure. (orig.)

  11. Monitoring of radiation exposure and registration of doses

    International Nuclear Information System (INIS)

    The guide defines the concepts relevant to the monitoring of radiation exposure and working conditions and provides guidelines for determining the necessity of monitoring and subsequently organizing it. In addition, instructions are given for reporting doses to the Dose Register of the Finnish Centre for Radiation and Nuclear Safety (STUK). Also the procedures are described for situations leading to exceptional exposures. (10 refs., 1 tab.)

  12. The Relationship between Ultraviolet Radiation Exposure and Vitamin D Status

    OpenAIRE

    Ola Engelsen

    2010-01-01

    This paper reviews the main factors influencing the synthesis of vitamin D, with particular focus on ultraviolet radiation exposure. On the global level, the main source of vitamin D is the sun. The effect of solar radiation on vitamin D synthesis depends to some extent on the initial vitamin D levels. At moderate to high latitudes, diet becomes an increasingly important source of vitamin D due to decreased solar intensity and cold temperatures, which discourage skin exposure. During the mid-...

  13. Implications of radiation-induced bystander effects and other non-targeted radiation effects for multi pollutant environmental exposures

    International Nuclear Information System (INIS)

    Environmentally relevant low doses of ionizing radiation are now accepted to induce a variety of biological effects at levels where it is difficult to implicate direct (targeted) DNA damage. These effects include bystander effects, genomic instability, adaptive responses and low dose hypersensitivity. The importance of these effects is that all are induced at very low doses. Typically one track of high LET radiation or less than 5 mGy of low LET radiation can trigger these effects. Once induced the level of effect does not increase with increasing dose and is persistent. The mechanisms underlying these effects are not known but it is accepted that genetic background is crucial in determining what the consequences of the exposure will be. This presentation will show 1. That chemical pollutants (heavy metals and micro-organics) can also induce these low dose responses, 2. That these effects can be induced in vivo as well as in vitro using mouse models exposed to whole body doses, 3. That the mechanism involves persistent elevation of ROS and that the effect can persist over many cell generations, 4. That chronic low dose exposures may actually be more effective than acute doses at inducing certain types of response, 5. That combinations of these inducers (whether radiation or chemical) and classical mutagens, can enhance the frequency of mutations due to the mutagen. There are implications for radiation and environmental protection which at present treat radiation as a 'stand alone' agent and assume a linear correlation between radiation dose and effect. (author)

  14. Functional status of liverin conditions of radiation and chemical exposure

    Directory of Open Access Journals (Sweden)

    O. V. Severynovs’ka

    2005-09-01

    Full Text Available Chronic influences of low-intensity X-rays in doses of 0.15 and 0.25 Gr and mix of heavy metals salts in a dose of 2 EPC (extreme permissible concentrations for each metal, as a single factor or as a combination of factors, on the state of pro-/antioxidative system in a rat liver have been studied. Analysis of the data concerning combined influences allows to conclude that effects under these doses have some differences: a splash of processes of lipid peroxidation are observed in both causes, but under the lower dose an additivity takes place, and under the dose of 0.25 Gr a synergism of the agent effects in relation to the development of peroxidative reactions is registered. The results testify that technogenic contamination of water with heavy metals worsens the action of radiation factor, specifically, eliminates a hormetic splash of antioxidative activity at 0.15 Gr. Biochemical indexes of the liver activity, as a central organ of a general metabolism, and a structure of morbidity have been studied in liquidators of the Chernobyl accident from industrial Prydnieprovie region. Disturbances of liver functions have been shown, especially in persons obtained the exposure dose about 0.25 Gr. A comparison of these results and data of tests with laboratory animals reveals their mutual accordance and supports a relevancy of extrapolation of data of model experiments on a person health state, which undergone a similar influence.

  15. Streptococcus bovis septicemia and meningitis associated with chronic radiation enterocolitis

    Energy Technology Data Exchange (ETDEWEB)

    Jadeja, L.; Kantarjian, H.; Bolivar, R.

    1983-12-01

    We describe the first patient with simultaneous S bovis septicemia and meningitis associated with chronic radiation enterocolitis. This case underlines the value of a thorough gastrointestinal evaluation of all patients with S bovis infection, and the need for a neurologic investigation even with minor neurologic manifestations.

  16. Exposure of the Spanish population to radiation from natural sources

    Energy Technology Data Exchange (ETDEWEB)

    Garcia-Talavera, M.; Suarez, E.; Matarranz, J.L.; Salas, R.; Ramos, L. [Consejo de Seguridad Nuclear. Justo Dorado, Madrid (Spain)

    2006-07-01

    We have assessed the exposure of the Spanish population to natural radiation sources. The annual average effective dose is estimated to be 2.38 mSv, taking into account contributions from cosmic radiation (13.8%), terrestrial gamma radiation (39%), radon and thoron inhalation (34%) and ingestion (13.2%). Cosmic radiation doses were calculated from town altitude data. Terrestrial gamma ray exposure outdoors was derived from the M.A.R.N.A. (natural gamma radiation map of Spain). Indoor gamma ray exposure was calculated by multiplying the corresponding outdoor value conversion factor, which was obtained by a linear least-squares fit of experimental measurements. Radon doses were estimated from national surveys carried out throughout the country. To assess doses by ingestion of water and foodstuffs we considered the results from a detailed study on consumption habits by age and geographical area in Spain, promoted by C.S.N., and average radioactivity values from UNSCEAR. (authors)

  17. Childhood cancer and occupational radiation exposure in parents

    International Nuclear Information System (INIS)

    To test the hypothesis that a parent's job exposure to radiation affeOR). its his or her child's risk of cancer, the authors compared this exposure during the year before the child's birth for parents of children with and without cancer. Parents of children with cancer were no more likely to have worked in occupations, industries, or combined occupations and industries with potential ionizing radiation exposure. Bone cancer and Wilms' tumor occurred more frequently among children of fathers in all industries with moderate potential ionizing radiation exposure. Children with cancer more often had fathers who were aircraft mechanics (odds ratio (OR)) . infinity, one-sided 95% lower limit . 1.5; P . 0.04). Although four of these six were military aircraft mechanics, only children whose fathers had military jobs with potential ionizing radiation exposure had an increased cancer risk (OR . 2.73; P . 0.01). Four cancer types occurred more often among children of fathers in specific radiation-related occupations: rhabdomyosarcoma among children whose fathers were petroleum industry foremen; retinoblastoma among children whose fathers were radio and television repairmen; central nervous system cancers and other lymphatic cancers among children of Air Force fathers. Because numbers of case fathers are small and confidence limits are broad, the associations identified by this study need to be confirmed in other studies. Better identification and gradation of occupational exposure to radiation would increase the sensitivity to detect associations

  18. Management of radio frequency radiation exposures in telecom Australia

    International Nuclear Information System (INIS)

    Telecom Australia is the largest non-military user of radio frequency radiation (RFR) in Australia and the management of risks to health from RFR exposure are discussed. The Australian RFR Exposure Standard forms that basis of risk assessment. Risk assessment and control procedures including the health surveillance of workers, other special occupational groups and members of the general public are outlined. (author)

  19. Radiation exposure of the crew in commercial air traffic

    International Nuclear Information System (INIS)

    The routine radiation exposure of the crews in Yugoslav Airlines (JAT) has been studied and some previous results are presented. The flights of four selected groups of pilots (four aircraft types) have been studied during one year. Annual exposures and dose equivalents are presented. Some additional results and discussions are given. (1 fig., 4 tabs.)

  20. Perception of natural, medical, and 'artificial' radiation exposures

    International Nuclear Information System (INIS)

    The paper discusses the imbalances in public perception and weighting factors attached by the media and consequently by politicians and by the general public, to the risks associated with the three main sources of population exposure, namely: natural radiation, diagnostic or therapeutic medical exposure and other artificial components including nuclear weapons tests, nuclear fuel cycles and reactor accidents. 15 refs

  1. Sharing good practices of radiation exposure reduction in Japan

    International Nuclear Information System (INIS)

    The yearly average exposure dose per reactor in Japan is relatively higher than other major countries. JNES held ALARA symposiums in Asia calling persons from abroad participated to collect the information on good practices of radiation exposure reduction measures and to share such information for promoting ALARA activities of utilities. (author)

  2. Exposure to ultraviolet-B radiation increases cold hardiness in Rhododendron

    International Nuclear Information System (INIS)

    The change in the cold hardiness of Rhododendron (cv. English Roseum) following chronic exposure to ultraviolet-B (UV-B) radiation (280–320 nm) was studied. Leaf disks removed from UV-B-exposed plants exhibited a greater tolerance to freezing temperatures than plants that received no UV-B exposure. Visual browning and percent phenolic leakage indicated that UV-B-exposed leaf disks were killed al -11°C. while control disks were killed at -8°C. Ultraviolet-induced production of phenolic compounds may be involved in increasing cold hardiness of Rhododendron leaf tissues

  3. Radiation exposure during travelling in Malaysia

    International Nuclear Information System (INIS)

    Absorbed dose rates in vehicles during travelling by different modes of transport in Malaysia were measured. Radiation levels measured on roads in Peninsular Malaysia were within a broad range, i.e. between 36 and 1560 nGy h-1. The highest reading, recorded while travelling near monazite and zircon mineral dumps, was 13 times the mean environmental radiation level of Malaysia. It is evident that radioactive material dumps on the roadsides can influence the radiation level on the road. The absorbed dose rates measured while travelling on an ordinary train were between 60 and 350 nGy h-1. The highest reading was measured when the train passed a tunnel built through a granite rock hill. The measurement during sea travelling by ferries gave the lowest radiation level owing to merely cosmic radiation at the sea level. (authors)

  4. Effects of chronic gamma radiation on the growth and survival of juvenile clams (Mercenaria mercenaria) and scallops (Argopecten irradians)

    International Nuclear Information System (INIS)

    Juvenile clams (Mercenaria mercenaria) and scallops (Argopecten irradians) from North Carolina were exposed to five intensities of chronic γ radiation for 3 to 14 months during 1973/1974. Exposure rates ranged downward from 37 rads/hr to levels slightly higher than background radiation. Deleterious effects on growth and survival of clams occurred only at the highest exposure rate (37 to 16 rads/hr). Clams exposed to low radiation levels (0.007 to 0.008 rads/hr) increased in weight, but not in length, faster than the controls. One-half of the clams exposed to the highest radiation level survived to 159 days, after a cumulative dose of 132 krads, and only 10 % survived to 14 months after a cumulative dose of 150 to 346 krads. No deleterious effects on growth and survival of scallops were apparent during 84 days of exposure to a cumulative radiation dose of 71.7 krads. (author)

  5. Radiation exposure of the population around Chernobyl

    International Nuclear Information System (INIS)

    Although the population in large parts of northern Ukraine, the region around Chernobyl, was resettled, these people are now returning to their accustomed agricultural environment - illegally, but tolerated. In order for evacuated villages to be cleared for resettlement, the dose commitment due to continuous external and internal exposures of the persons returning must be determined. Examination concentrates on the fallout of reactor nuclides, the path of radionuclides through the food chain to people, and on present and post exposures. Special attention in this respect is paid to the deposition density of cesium. On the basis of the data collected so far, the village inhabitants considered in 1998/99 suffer an average external exposure of 0.7±0.2 mSv/a in addition to the natural external exposure of 0.8 mSv/a and, with a conversion factor of 0.038 mSv/a per kBq of 137 Cs whole body activity [8], 0.5±0.2 mSv/a (excluding inhabitants 17 and 18) of additional internal exposure, mainly as a function of mushroom intake. The ban on consumption of mushrooms and fruit growing in the forests, and education of the public about the reasons for it, could help to reduce the additional internal exposure further to approx. 0.1 mSv/a. (orig.)

  6. Radiation exposure from diagnostic imaging among patients with gastrointestinal disorders.

    LENUS (Irish Health Repository)

    Desmond, Alan N

    2012-03-01

    There are concerns about levels of radiation exposure among patients who undergo diagnostic imaging for inflammatory bowel disease (IBD), compared with other gastrointestinal (GI) disorders. We quantified imaging studies and estimated the cumulative effective dose (CED) of radiation received by patients with organic and functional GI disorders. We also identified factors and diagnoses associated with high CEDs.

  7. A specific case: Cosmic radiation exposures of flight crew

    International Nuclear Information System (INIS)

    Full text: The average annual effective dose due to occupational cosmic radiation exposure is 3.0 mSv (about 60% neutrons), which is higher than that due to other enhanced natural sources such as coal mining, non-coal mining or mineral processing according to the United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) 2000 Report. Individual variability in annual exposures can be up to 25 fold (0.25 mSv/a), depending on the routes flown, which are often related to seniority in the profession. The collective dose for aircrew is 320 man Sv/a (UNSCEAR 1993 Report). In the specific case of cosmic radiation exposure of aircrew, the radiation control options include rotation of staff for reduction in individual hours worked, reduction in aircraft altitudes, reduction in flight route latitudes and postponement or rerouting of flights during known solar particle events. In the classic occupational hygiene exposure control paradigm, these measures would be categorized as administrative controls: reducing the time exposed or increasing the distance to source. Clearly, there are no feasible engineering controls or personal protective controls such as aircraft or personal shielding. International Commission on Radiological Protection Publication 60 (1991) provided international recommendations that practices involving radiation exposures be justified by benefit to individuals or society, that protection be optimized by constraining individual doses or risks, and that limits be set for individual doses and risks. Additionally, proposed interventions should do more harm than good and the cost benefit should be maximized. However, from a regulatory standpoint, differences exist between countries in the approach taken. In the United States of America, aircrew are not yet considered radiation workers and occupational exposures to cosmic radiation are still treated as unregulated natural background radiation. The US Federal Aviation Administration (FAA

  8. Systematic for assessment of occupational exposure to ultraviolet radiation

    International Nuclear Information System (INIS)

    The approval of Royal Decree 486/2010 of 23 April on the protection of health and safety of workers from risks related to exposure to artificial optical radiation, moves to state law a framework of protection against the radiation. This should involve a significant intensification of control at work is conducted in this radiation. Despite the complexity of the issue and limit values ??difficult to apply (for incoherent ultraviolet radiation enters the bounding box up to 5 different values ??may apply), requires a systematic analysis of the problem well done. In this paper we consider the ultraviolet radiation generated by artificial sources.

  9. Fitness of equipment used for medical exposures to ionising radiation

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-07-01

    The advice in this guidance note is aimed at employers in control of equipment used for medical exposures to ionising radiation and ancillary equipment. This includes NHS trusts, health authorities or boards, private hospitals, clinics, surgeries, medical X-ray facilities in industry, dentists and chiropractors. The guidance should also be useful to radiation protection advisers appointed by such employers. The guidance provides advice on the requirements of regulation 33 of the Ionising Radiations Regulations 1985 (IRR85). In particular, it covers: (a) the selection, installation, maintenance, calibration and replacement of equipment to ensure that it is capable of restricting, so far as reasonably practicable, the medical exposure of any person to the extent that this is compatible with the intended diagnostic or therapeutic purpose; (b) recommended procedures for the definitive calibration of radiotherapy treatment; and (c) the need to investigate incidents involving a malfunction or defect in any 'radiation equipment' which result in medical exposures much greater than intended and to notify the Health and Safety Executive (HSE). 'Medical exposure' is defined in IRR85 as exposure of a person to ionising radiation for the purpose of his or her medical or dental examination or treatment which is conducted under the direction of a suitably qualified person and includes any such examination or treatment conducted for the purposes of research. For convenience, people undergoing medical exposure will be referred to as 'patients' in this guidance. Nothing in this publication is intended to indicate whether or not patients should be informed of any incident resulting from malfunction or defect in equipment used for medical exposure and the possible consequences of that exposure. As stated above, this guidance concerns medical exposures much greater than intended and although exposures much lower than intended can also have serious

  10. Fitness of equipment used for medical exposures to ionising radiation

    International Nuclear Information System (INIS)

    The advice in this guidance note is aimed at employers in control of equipment used for medical exposures to ionising radiation and ancillary equipment. This includes NHS trusts, health authorities or boards, private hospitals, clinics, surgeries, medical X-ray facilities in industry, dentists and chiropractors. The guidance should also be useful to radiation protection advisers appointed by such employers. The guidance provides advice on the requirements of regulation 33 of the Ionising Radiations Regulations 1985 (IRR85). In particular, it covers: (a) the selection, installation, maintenance, calibration and replacement of equipment to ensure that it is capable of restricting, so far as reasonably practicable, the medical exposure of any person to the extent that this is compatible with the intended diagnostic or therapeutic purpose; (b) recommended procedures for the definitive calibration of radiotherapy treatment; and (c) the need to investigate incidents involving a malfunction or defect in any 'radiation equipment' which result in medical exposures much greater than intended and to notify the Health and Safety Executive (HSE). 'Medical exposure' is defined in IRR85 as exposure of a person to ionising radiation for the purpose of his or her medical or dental examination or treatment which is conducted under the direction of a suitably qualified person and includes any such examination or treatment conducted for the purposes of research. For convenience, people undergoing medical exposure will be referred to as 'patients' in this guidance. Nothing in this publication is intended to indicate whether or not patients should be informed of any incident resulting from malfunction or defect in equipment used for medical exposure and the possible consequences of that exposure. As stated above, this guidance concerns medical exposures much greater than intended and although exposures much lower than intended can also have serious consequences, the incident would not

  11. Evaluation of exposure to ionizing radiation among gamma camera operators

    OpenAIRE

    Agnieszka Anna Domańska; Małgorzata Bieńkiewicz; Jerzy Olszewski

    2013-01-01

    Background: Protection of nuclear medicine unit employees from hazards of the ionizing radiation is a crucial issue of radiation protection services. We aimed to assess the severity of the occupational radiation exposure of technicians performing scintigraphic examinations at the Nuclear Medicine Department, Central Teaching Hospital of Medical University in Łódź, where thousands of different diagnostic procedures are performed yearly. Materials and Methods: In 2013 the studied diagnostic uni...

  12. Cosmic radiation and air crew exposure

    International Nuclear Information System (INIS)

    When the primary particles from space, mainly protons, enter the atmosphere, they interact with the air nuclei and induce cosmic-ray shower. When an aircraft is in the air, the radiation field within includes many types of radiation of large energy range; the field comprises mainly photons, electrons, positrons and neutrons. Cosmic radiation dose for crews of air crafts A 320 and ATR 42 was measured using TLD-100 (LiF: Mg, Ti) detectors and the Mini 6100 semiconductor dosimeter; radon concentration in the atmosphere was measured using the Alpha Guard radon detector. The total annual dose estimated for the A 320 aircraft crew, at altitudes up to 12000 meters, was 5.3 mSv (including natural radon radiation dose of 1.1 mSv).(author)

  13. Occupational radiation exposure and mortality study

    International Nuclear Information System (INIS)

    An epidemiological cohort study of some 300,000 Canadians enrolled in the National Dose Registry (NDR) is being undertaken to determine if there is excess cancer or other causes of mortality among those workers who are occupationally exposed to low levels of ionizing radiation. The results of this study may provide better understanding of the dose-response relationship for low doses of ionizing radiation and aid in the verification of risk estimates for radiation-induced cancer mortality. The Department of National Health and Welfare (DNHW) is responsible for the Registry; this study is being carried out by the Bureau of Radiation and Medical Devices (BRMD) with financial assistance and co-operation of various agencies including Statistics Canada and the Atomic Energy Control Board

  14. Radiation exposures by the occupational distribution of thoriated gas mantles

    International Nuclear Information System (INIS)

    The radiation exposure for the different exposed groups due to the distribution of thoriated gas mantles and their associated emitted radiation, has been evaluated by measurements and calculations. Because there are so many possible exposition scenarios, only a few typical cases have been considered. The thereby determined expositions yielded effective doses which lay between 0,01 and 3,16 mSv per year. After carrying out investigations in all the possible exposition scenarios it proved possible to estimate a value of 10 mSv per years as the upper limit for radiation exposure due to distribution of thoriated gas mantles. (orig.)

  15. Monitoring of radiation exposure and registration of doses

    International Nuclear Information System (INIS)

    The Section 32 of the Finnish Radiation Act (592/91) defines the requirements to be applied to the monitoring of the radiation exposure and working conditions in Finland. The concepts relevant to the monitoring and guidelines for determining the necessity of the monitoring as well as its organizing are given in the guide. Instructions for reporting doses to the Dose Register of the Finnish Centre for Radiation and Nuclear Safety (STUK) are given, also procedures for situations leading to exceptional exposures are described. (9 refs.)

  16. A review of the population radiation exposure at TMI-2

    International Nuclear Information System (INIS)

    The exposure of the public to radiation during and following the accident at Three Mile Island, Unit 2 was small. On the average it was only a few percent of natural background radiation and no one was exposed to amounts comparable to background radiation. Much of the detection equipment saw radiation levels too low to permit accurate measurements. This project identified and compared the work of various investigations in terms of methodology and the determination of radiation exposure to the population. The work included such refinements as (1) the utilization of better estimates of population density and distribution, (2) quantification of the effects of detector calibration, (3) an evaluation of the effects of buildings in shielding individuals from airborne radioactivity, (4) the reduction in population exposure due to the partial evacuation of the public, and (5) a determination of the effect on population exposure of not considering radiation exposures to individuals that are below about 0.5% of the combined yearly natural background and medical levels. (author)

  17. Radiation exposure to personnel in diagnostic nuclear medicine

    International Nuclear Information System (INIS)

    Investigations under routine conditions concerning the following points; were undertaken. External radiation exposure by Tc-99m to the whole body and to the hands or finger tips of nuclear technicians, physicians and radiochemists; external exposure by Tc-99m to whole body and gonads of nurses in a neurologic intensive care unit with a high frequency of patients who undergo nuclear medicine investigations; the risk to incorporate I-125 in a radioimmunoassay laboratory and in a labelling laboratory. The data show that external radiation exposure from Tc-99m to personnel working in diagnostic nuclear medicine where a total dose of 50 Ci of Tc-99m is applied per year remains far below the maximum permissible doses if the following measures are strictly fullfilled: - Elution, labelling and filling of Tc-99m radiopharmaceuticals only in shielded vials and using long distance working tools. - Application of Tc-99m radiopharmaceuticals using exclusively shielded syringes. - Time of staying next to Tc-99m containing patients as short as possible. Under these conditions, it is unnecessary that personnel who nurses patients with diagnostic nuclear medicine procedure in an intensive care unit are put under radiation control by personnel radiation dosimetry. The internal radiation exposure by inhalation of I-125 which evaporates from radioimmunoassay test tubes is negligible. But there is a risk of external and internal radiation exposure from labelling procedures with radionuclides of iodine, if special protective measures are not carefully considered

  18. Health Effects of Exposure to Low Dose of Radiation

    International Nuclear Information System (INIS)

    Human beings are exposed to natural radiation from external sources include radionuclides in the earth and cosmic radiation, and by internal radiation from radionuclides, mainly uranium and thorium series, incorporated into the body. Living systems have adapted to the natural levels of radiation and radioactivity. But some industrial practices involving natural resources enhance these radionuclides to a degree that they may pose risk to humans and the environment if they are not controlled. Biological effects of ionizing radiation are the outcomes of physical and chemical processes that occur immediately after the exposure, then followed by biological process in the body. These processes will involve successive changes in the molecular, cellular, tissue and whole organism levels. Any dose of radiation, no matter how small, may produce health effects since even a single ionizing event can result in DNA damage. The damage to DNA in the nucleus is considered to be the main initiating event by which radiation causes damage to cells that results in the development of cancer and hereditary disease. It has also been indicated that cytogenetic damage can occur in cells that receive no direct radiation exposure, known as bystander effects. This paper reviews health risks of low dose radiation exposure to human body causing stochastic effects, i.e. cancer induction in somatic cells and hereditary disease in genetic cells. (author)

  19. Radiation exposure to the patient during closed intramedullary nailing

    International Nuclear Information System (INIS)

    Material and Method. 39 patients with pertrochanteric femur fracture (n=32) or lower leg fracture (n=7) were treated with closed intramedullary nailing. The related radiation exposure of the patients was calculated. Results. Osteosynthesis of pertrochanteric fractures took less fluoroscopic time than osteosynthesis of lower leg fractures. The effective dose was 14 mSv for nailing osteosynthesis of proximal pertrochanteric fractures and less than 0.1 mSv for osteosynthesis of distal lower leg fractures. Conclusion. Radiation exposure of the patient due to intraoperative fluoroscopic imaging during osteosynthesis can be estimated based on the data given above. Intraoperative observations imply, consequent application of radiation protection by the orthopaedic surgeons may reduce intraoperative radiation exposure even more. (orig.)

  20. Chronic obstructive pulmonary disease (COPD and occupational exposures

    Directory of Open Access Journals (Sweden)

    Zeni Elena

    2006-06-01

    Full Text Available Abstract Chronic obstructive pulmonary disease (COPD is one of the leading causes of morbidity and mortality in both industrialized and developing countries. Cigarette smoking is the major risk factor for COPD. However, relevant information from the literature published within the last years, either on general population samples or on workplaces, indicate that about 15% of all cases of COPD is work-related. Specific settings and agents are quoted which have been indicated or confirmed as linked to COPD. Coal miners, hard-rock miners, tunnel workers, concrete-manufacturing workers, nonmining industrial workers have been shown to be at highest risk for developing COPD. Further evidence that occupational agents are capable of inducing COPD comes from experimental studies, particularly in animal models. In conclusion, occupational exposure to dusts, chemicals, gases should be considered an established, or supported by good evidence, risk factor for developing COPD. The implications of this substantial occupational contribution to COPD must be considered in research planning, in public policy decision-making, and in clinical practice.

  1. Radiation protection aspects of the cosmic radiation exposure of aircraft crew

    International Nuclear Information System (INIS)

    Aircraft crew and frequent flyers are exposed to elevated levels of cosmic radiation of galactic and solar origin and secondary radiation produced in the atmosphere, the aircraft structure and its contents. Following recommendations of the International Commission on Radiological Protection in Publication 60, the European Union introduced a revised Basic Safety Standards Directive, which included exposure to natural sources of ionising radiation, including cosmic radiation, as occupational exposure. The revised Directive has been incorporated into laws and regulations in the European Union Member States. Where the assessment of the occupational exposure of aircraft crew is necessary, the preferred approach to monitoring is by the recording of staff flying times and calculated route doses. Route doses are to be validated by measurements. This paper gives the general background, and considers the radiation protection aspects of the cosmic radiation exposure of aircraft crew, with the focus on the situation in Europe. (authors)

  2. Operational Prototype Development of a Global Aircraft Radiation Exposure Nowcast

    Science.gov (United States)

    Mertens, Christopher; Kress, Brian; Wiltberger, Michael; Tobiska, W. Kent; Bouwer, Dave

    Galactic cosmic rays (GCR) and solar energetic particles (SEP) are the primary sources of human exposure to high linear energy transfer (LET) radiation in the atmosphere. High-LET radiation is effective at directly breaking DNA strands in biological tissue, or producing chemically active radicals in tissue that alter the cell function, both of which can lead to cancer or other adverse health effects. A prototype operational nowcast model of air-crew radiation exposure is currently under development and funded by NASA. The model predicts air-crew radiation exposure levels from both GCR and SEP that may accompany solar storms. The new air-crew radiation exposure model is called the Nowcast of Atmospheric Ionizing Radiation for Aviation Safety (NAIRAS) model. NAIRAS will provide global, data-driven, real-time exposure predictions of biologically harmful radiation at aviation altitudes. Observations are utilized from the ground (neutron monitors), from the atmosphere (the NCEP Global Forecast System), and from space (NASA/ACE and NOAA/GOES). Atmospheric observations characterize the overhead mass shielding and the ground-and space-based observations provide boundary conditions on the incident GCR and SEP particle flux distributions for transport and dosimetry calculations. Radiation exposure rates are calculated using the NASA physics-based HZETRN (High Charge (Z) and Energy TRaNsport) code. An overview of the NAIRAS model is given: the concept, design, prototype implementation status, data access, and example results. Issues encountered thus far and known and/or anticipated hurdles to research to operations transition are also discussed.

  3. Tissue response after radiation exposure. Intestine

    International Nuclear Information System (INIS)

    Gastrointestinal syndrome followed by 'gut death' is due to intestinal disorders. This syndrome is induced by high-dose (>10 Gy) of ionizing radiation. Recovery from the gastrointestinal syndrome would depend on the number of survived clonogens and regeneration capability of crypts. These tissue alterations can be observed by high-dose radiation, however, cellular dynamics in crypts can be affected by low-dose radiation. For example, Potten et al. found that low-dose radiation induce apoptosis of intestinal stem cells, which produce all differentiated function cells. Recently, intestinal stem cells are characterized by molecular markers such as Lgr5. Since intestinal adenomas can be induced by deletion of Apc gene in Lgr5+ stem cells, it is widely recognized that Lgr5+ stem cells are the cell-of-origin of cancer. Duodenal Lgr5+ stem cells are known as radioresistant cells, however, we found that ionizing radiation significantly induces the turnover of colonic Lgr5+ stem cells. Combined with the knowledge of other radioresistant markers, stem-cell dynamics in tissue after irradiation are becoming clear. The present review introduces the history of gastrointestinal syndrome and intestinal stem cells, and discusses those future perspectives. (author)

  4. Occupational radiation exposure monitoring among radiation workers in Nepal

    International Nuclear Information System (INIS)

    Nepal was accepted as a member of the IAEA in 2007. Nepal is one of the world's least developed countries and is defined in Health Level IV. The population counted 26.4 millions in 2007. The health care sector increases with new hospitals and clinics, however, Nepal has no radiation protection authority or radiation protection regulation in the country until now. The radiation producing equipment in the health sector includes conventional X-ray and dental X-ray equipment, fluoroscopes, mammography, CT, catheterization laboratory equipment, nuclear medicine facilities, a few linear accelerators, Co60 teletherapy and High Dose Rate brachytherapy sources. The situation regarding dosimetry service for radiation workers is unclear. A survey has been carried out to give an overview of the situation. The data collection of the survey was performed by phone call interviews with responsible staff at the different hospitals and clinics. Data about different occupationally exposed staff, use of personal radiation monitoring and type of dosimetry system were collected. In addition, it was asked if dosimetry reports were compiled in files or databases for further follow-up of staff, if needed. The survey shows that less of 25% of the procedures performed on the surveyed hospitals and clinics are performed by staff with personnel radiation monitoring. Radiation monitoring service for exposed staff is not compulsory or standardized, since there is no radiation protection authority. Nepal has taken a step forward regarding radiation protection, with the IAEA membership, although there are still major problems that have to be solved. An evaluation of the existing practice of staff dosimetry can be the first helpful step for further work in building a national radiation protection authority. (author)

  5. Understanding of radiation protection in medicine. Pt. 2. Occupational exposure and system of radiation protection

    International Nuclear Information System (INIS)

    Using a questionnaire we investigated whether radiation protection is correctly understood by medical doctors (n=140) and nurses (n=496). Although medical exposure is usually understood by medical doctors and dentists, their knowledge was found to be insufficient. Sixty-eight percent of medical doctors and 50% of dentists did not know about the system of radiation protection. Dose monitoring was not correctly carried out by approximately 20% of medical staff members, and medical personnel generally complained of anxiety about occupational exposure rather than medical exposure. They did not receive sufficient education on radiation exposure and protection in school. In conclusion, the results of this questionnaire suggested that they do not have adequate knowledge about radiation exposure and protection. The lack of knowledge about protection results in anxiety about exposure. To protect oneself from occupational exposure, individual radiation doses must be monitored, and medical practice should be reconsidered based on the results of monitoring. To eliminate unnecessary medical and occupational exposure and to justify practices such as radiological examinations, radiation protection should be well understood and appropriately carried out by medical doctors and dentists. Therefore, the education of medical students on the subject of radiation protection is required as is postgraduate education for medical doctors, dentists and nurses. (author)

  6. Radiation exposure of airline crew members to the atmospheric ionizing radiation environment

    International Nuclear Information System (INIS)

    A study of radiation exposures in the ionizing radiation environment of the atmosphere is currently in progress for the Italian civil aviation flight personnel. After a description of the considered data sources/ the philosophy of the study is presented/ and an overview is given of the data processing with regard to flight routes/ the computational techniques for radiation dose evaluation along the flight paths and for the exposure matrix building/ along with an indication of the results that the study should provide.

  7. Occupational exposure to natural sources of radiation

    International Nuclear Information System (INIS)

    The most important natural sources of radiation are analyzed. The situation in France, Italy, and Spain concerning protection against natural radiation is described, including the identification of sources, and defined practices, organizations charged of national surveys and the responsibility of regulatory bodies and the role of operating management. The activities of the international organizations (ICRP, CEC and IAEA) are presented and discussed, and existing actions toward harmonization in the CEC, IAEA and other international programs is also discussed. (R.P.) 23 refs., 2 tabs

  8. Occupational radiation protection: Protecting workers against exposure to ionizing radiation. Contributed papers

    International Nuclear Information System (INIS)

    Occupational exposure to ionizing radiation can occur in a range of industries, mining and milling; medical institutions, educational and research establishments and nuclear fuel cycle facilities. The term 'occupational exposure' refers to the radiation exposure incurred by a worker, which is attributable to the worker's occupation and committed during a period of work. According to the latest (2000) Report of the United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR), an estimated 11 million workers are monitored for exposure to ionizing radiation. They incur radiation doses attributable to their occupation, which range from a small fraction of the global average background exposure to natural radiation up to several times that value. It should be noted that the UNSCEAR 2000 Report describes a downward trend in the exposure of several groups of workers, but it also indicates that occupational exposure is affecting an increasingly large group of people worldwide. The International Basic Safety Standards for Protection against Ionizing Radiation and for the Safety of Radiation Sources (BSS), which are co-sponsored by, inter alia, the International Atomic Energy Agency (IAEA), the International Labour Organization (ILO), the OECD Nuclear Energy Agency (NEA) and the World Health Organization (WHO), establish a system of radiation protection which includes radiation dose limits for occupational exposure. Guidance supporting the requirements of the BSS for occupational protection is provided in three interrelated Safety Guides, jointly sponsored by the IAEA and the ILO. These Guides describe, for example, the implications for employers in discharging their main responsibilities (such as setting up appropriate radiation protection programmes) and similarly for workers (such as properly using the radiation monitoring devices provided to them). The IAEA i organized its first International Conference on Occupational Radiation Protection. The

  9. Some problem of emergency exposure medical system and radiation protection

    International Nuclear Information System (INIS)

    Fukushima nuclear accident was a complex disaster and then clarified some problem of emergency exposure medical system. This article described such problem and introduced nuclear emergency preparedness guidelines focusing on exposure medical matter. At the initial stage of the accident, 5 initial exposure medical organizations like the off-site center could not work at all. Secondary exposure medical organization was regional core hospital and had excessive medical loads. Third organizations dispatched exposure medical support teams to the site to rebuild the emergency exposure medical system. Emergency evacuation of patients and preventive use of stabilized iodine tablets should be well prepared. At radiation accidents, radiation protection measures should be chosen for exposure path and accident stage such as emergency exposure situation or existing exposure situation. Comprehensive standards for deterministic and probabilistic effects with relevant measure to prevent or minimize effects or reduce probabilistic risks were tabulated from IAEA documents for the reference. Emergency Action Level (EAL) and Operation Intervention Level (OIL) should be predetermined to start protective measures. Emergency was classified into three categories: Alert, site emergency and general emergency. Assuming general emergency, protective measures were considered for respective zones of PAZ (Precautionary Active Zone), UPZ (Urgent Protective action Planning Zone) and PPA (Plume Protection Planning Area, under consideration). (T. Tanaka)

  10. Dose evaluation for external exposure in radiation accidents

    International Nuclear Information System (INIS)

    Abnormal exposures including emergency and accidental are categorized into external exposure and internal contamination, although both of these may be associated with external contamination. From a point of view of lifesaving in the abnormal exposures, it is primarily important to evaluate radiation dose of exposed persons as soon as possible. This report reviews the status of early dosimetry in the accidental exposures and discusses the optimum methodology of the early dose determination for external exposures in abnormal exposures. Personal monitors generally give an indication of dose to an exposed person only at a single part of the body. The data obtained from the personal monitors should be interpreted with care and in the light of information about the circumstances of exposure. In most cases, the records of environmental monitors or the survey with area monitors provide valuable information on the radiation fields. In the some cases, the reconstruction of the abnormal exposure is required for the dose evaluation by means of phantom experiments. In the case of neutron exposures, activation products in the body or its components or personnel possession can be useful for the early dosimetry. If the dose received by the whole body is evaluated as being very high, clinical observations and biological investigations may be more important guide to initial medical treatment than the early dosimetry. For the dose evaluation of general public, depending on the size of abnormal exposure, information that could be valuable in the assessment of abnormal exposures will come from the early dose estimates with environmental monitors and radiation survey meters. (author)

  11. Patient cumulative radiation exposure in interventional cardiology

    International Nuclear Information System (INIS)

    Interventional cardiology procedures can involve potentially high doses of radiation to the patients. Stochastic effects of ionising radiation - radiation-induced cancers in the long term - may occur. We analysed clinical characteristics and dosimetric data in a population of patients undergoing interventional cardiology. In all, 1 591 patients who had undergone coronarography and/or angioplasty in the course of a year at the Saint-Gatien Clinic in Tours (France) were included. Information on patients' individual clinical characteristics and Dose-Area Product values were collected. Organ doses to the lung, oesophagus, bone marrow and breast were mathematically evaluated. The median age of patients was 70 years. Their median cumulative dose-area product value was 48.4 Gy.cm2 for the whole year and the median effective dose was 9.7 mSv. The median organ doses were 41 mGy for the lung, 31 mGy for the oesophagus, 10 mGy for the bone marrow and 4 mGy for the breast. Levels of doses close to the heart appear to be rather high in the case of repeated interventional cardiology procedures. Clinical characteristics should be taken into account when planning epidemiological studies on potential radiation-induced cancers. (authors)

  12. Assigning a value to transboundary radiation exposure

    International Nuclear Information System (INIS)

    The document offers guidance on the application of the Basic Safety Standards with regard to the particular problem of using differential cost-benefit analysis in the optimization of radiation protection in the case of transboundary radioactive pollution. Examples of optimization of 14C retention at a nuclear power plant and of 85Kr retention at a reprocessing plant are presented

  13. Prototype Development of an Operational Global Aircraft Radiation Exposure Nowcast

    Science.gov (United States)

    Mertens, C. J.; Tobiska, W.; Bouwer, D.; Kress, B. T.; Wiltberger, M. J.; Solomon, S. C.; Kunches, J.

    2009-12-01

    A prototype operational nowcast model of air-crew radiation exposure is currently under development and funded by NASA. The model predicts air-crew radiation exposure levels from both background galactic cosmic rays (GCR) and solar energetic particle events (SEP) that may accompany solar storms. The new air-crew radiation exposure model is called the Nowcast of Atmospheric Ionizing Radiation for Aviation Safety (NAIRAS) model. NAIRAS will provide global, data-driven, real-time exposure predictions of biologically harmful radiation at aviation altitudes. Observations are utilized from the ground (neutron monitors), from the atmosphere (the NCEP Global Forecast System), and from space (NASA/ACE and NOAA/GOES). Atmospheric observations provide the overhead mass shielding information and the ground- and space-based observations provide boundary conditions on the incident GCR and SEP particle flux distributions for transport and dosimetry calculations. Exposure rates are calculated using the NASA physics-based HZETRN (High Charge (Z) and Energy TRaNsport) code. An overview of the NAIRAS model is given: the concept, design, prototype implementation status, data access, and example results. We also discuss issues encounter thus far as well as anticipated hurdles in the research to operations transition process.

  14. Radiation in the living environment: sources, exposure and effects

    International Nuclear Information System (INIS)

    We are living in a milieu of radiations and continuously exposed to radiations from natural sources from conception to death. We are exposed to radiation from Sun and outer space, radioactive materials present in the earth, house we live in, buildings and workplace, food we eat and air we breath. Each flake of snow, grain of soil, drop of rain, a flower, and even each man in the street is a source of this radiation. Even our own bodies contain naturally occurring radioactive elements. The general belief is that the radiations are harmful and everybody is scared of the same. The cancer is the most important concern on account of exposure to Ionizing Radiation which is initiated by the damage to DNA. The level of exposure depends on the environmental and working conditions and may vary from low to moderate to high and depending on the same the exposed humans can be classified as general public, non nuclear workers (NNW) and nuclear workers (NW). Though, the LNT theory which is considered to be the radiation paradigm considers all radiation at all levels to be harmful and the -severity of the deleterious effect increases with the increase in dose, however, the available literature, data and reports (epidemiological and experimental) speaks otherwise particularly at low levels. The purpose of this paper is to address the question, whether the radiation is harmful at all levels or it is simply media hype and the truth is different, and to promote harmony with nature and to improve our quality of life with the knowledge that cancer mortality rates decrease following exposure to LLIR. Various sources of radiation exposure and the subsequent consequences will be discussed. (author)

  15. Health Impacts from Acute Radiation Exposure

    Energy Technology Data Exchange (ETDEWEB)

    Strom, Daniel J.

    2003-09-30

    Absorbed doses above1-2 Gy (100-200 rads) received over a period of a day or less lead to one or another of the acute radiation syndromes. These are the hematopoietic syndrome, the gastrointestinal (GI) syndrome, the cerebrovascular (CV) syndrome, the pulmonary syndrome, or the cutaneous syndrome. The dose that will kill about 50% of the exposed people within 60 days with minimal medical care, LD50-60, is around 4.5 Gy (450 rads) of low-LET radiation measured free in air. The GI syndrome may not be fatal with supportive medical care and growth factors below about 10 Gy (1000 rads), but above this is likely to be fatal. Pulmonary and cutaneous syndromes may or may not be fatal, depending on many factors. The CV syndrome is invariably fatal. Lower acute doses, or protracted doses delivered over days or weeks, may lead to many other health outcomes than death. These include loss of pregnancy, cataract, impaired fertility or temporary or permanent sterility, hair loss, skin ulceration, local tissue necrosis, developmental abnormalities including mental and growth retardation in persons irradiated as children or fetuses, radiation dermatitis, and other symptoms listed in Table 2 on page 12. Children of parents irradiated prior to conception may experience heritable ill-health, that is, genetic changes from their parents. These effects are less strongly expressed than previously thought. Populations irradiated to high doses at high dose rates have increased risk of cancer incidence and mortality, taken as about 10-20% incidence and perhaps 5-10% mortality per sievert of effective dose of any radiation or per gray of whole-body absorbed dose low-LET radiation. Cancer risks for non-uniform irradiation will be less.

  16. Radiation load from radon exposure in Slovakia

    International Nuclear Information System (INIS)

    In this paper the results of monitoring of radon exposure in Slovakia by passive solid state nuclear track detectors (SSNTD ) (placed in about 6,000 selected dwellings, 1000 selected buildings of the kindergartens and basic schools, 12 selected spa buildings) and personal doses measured by SSNTD (130 miners from three ore mines and 13 tourist guides from seven show karst caves) are presented. The national survey results suggest that Slovak Republic may be among the countries with higher radon risk in Central Europe. The annual effective dose from indoor radon exposure is 2.1 mSv per inhabitants. The district with highest indoor radon concentrations and districts with high radon levels in spa buildings correlate with known presence of uranium in the soil. The soil is probably the main source of radon in Slovak dwellings, spa and school buildings too

  17. The accidental exposure to ionizing radiations

    International Nuclear Information System (INIS)

    This article is divided in three parts, the first one gives the radioactivity sources, the doses and the effects, the second part is devoted to the medical exposures, the third part concerns the accidents and the biological effects of an irradiation the different syndromes ( the acute whole-body irradiation syndrome, the localized irradiation syndrome, the inflammatory syndrome, hematopoietic syndrome,neuro-vascular syndrome) are detailed. (N.C.)

  18. Occupational cosmic radiation exposure and cancer in airline cabin crew

    International Nuclear Information System (INIS)

    Cosmic radiation dose rates are considerably higher at cruising altitudes of airplanes than at ground level. Previous studies have found increased risk of certain cancers among aircraft cabin crew, but the results are not consistent across different studies. Despite individual cosmic radiation exposure assessment is important for evaluating the relation between cosmic radiation exposure and cancer risk, only few previous studies have tried to develop an exposure assessment method. The evidence for adverse health effects in aircrews due to ionizing radiation is inconclusive because quantitative dose estimates have not been used. No information on possible confounders has been collected. For an occupational group with an increased risk of certain cancers it is very important to assess if the risk is related to occupational exposure. The goal of this thesis was to develop two separate retrospective exposure assessment methods for occupational exposure to cosmic radiation. The methods included the assessment based on survey on flight histories and based on company flight timetables. Another goal was to describe the cancer incidence among aircraft cabin crew with a large cohort in four Nordic countries, i.e., Finland, Iceland, Norway, and Sweden. Also the contribution of occupational as well as non-occupational factors to breast and skin cancer risk among the cabin crew was studied with case-control studies. Using the survey method of cosmic radiation exposure assessment, the median annual radiation dose of Finnish airline cabin crew was 0.6 milliSievert (mSv) in the 1960s, 3.3 mSv in the 1970s, and 3.6 mSv in the 1980s. With the flight timetable method, the annual radiation dose increased with time being 0.7 mSv in the 1960 and 2.1 mSv in the 1995. With the survey method, the median career dose was 27.9 mSv and with the timetable method 20.8 mSv. These methods provide improved means for individual cosmic radiation exposure assessment compared to studies where cruder

  19. Occupational cosmic radiation exposure and cancer in airline cabin crew.

    Energy Technology Data Exchange (ETDEWEB)

    Kojo, K.

    2013-03-15

    Cosmic radiation dose rates are considerably higher at cruising altitudes of airplanes than at ground level. Previous studies have found increased risk of certain cancers among aircraft cabin crew, but the results are not consistent across different studies. Despite individual cosmic radiation exposure assessment is important for evaluating the relation between cosmic radiation exposure and cancer risk, only few previous studies have tried to develop an exposure assessment method. The evidence for adverse health effects in aircrews due to ionizing radiation is inconclusive because quantitative dose estimates have not been used. No information on possible confounders has been collected. For an occupational group with an increased risk of certain cancers it is very important to assess if the risk is related to occupational exposure. The goal of this thesis was to develop two separate retrospective exposure assessment methods for occupational exposure to cosmic radiation. The methods included the assessment based on survey on flight histories and based on company flight timetables. Another goal was to describe the cancer incidence among aircraft cabin crew with a large cohort in four Nordic countries, i.e., Finland, Iceland, Norway, and Sweden. Also the contribution of occupational as well as non-occupational factors to breast and skin cancer risk among the cabin crew was studied with case-control studies. Using the survey method of cosmic radiation exposure assessment, the median annual radiation dose of Finnish airline cabin crew was 0.6 milliSievert (mSv) in the 1960s, 3.3 mSv in the 1970s, and 3.6 mSv in the 1980s. With the flight timetable method, the annual radiation dose increased with time being 0.7 mSv in the 1960 and 2.1 mSv in the 1995. With the survey method, the median career dose was 27.9 mSv and with the timetable method 20.8 mSv. These methods provide improved means for individual cosmic radiation exposure assessment compared to studies where cruder

  20. Skin cancer in patients with chronic radiation dermatitis

    Energy Technology Data Exchange (ETDEWEB)

    Davis, M.M.; Hanke, C.W.; Zollinger, T.W.; Montebello, J.F.; Hornback, N.B.; Norins, A.L.

    1989-04-01

    The cases of 76 patients with chronic radiation dermatitis resulting from low-dose ionizing radiation for benign disease were reviewed retrospectively for risk factors leading to the development of neoplasia. The patients were studied with respect to original hair color, eye color, sun reactive skin type, benign disease treated, area treated, age at treatment, and age at development of first skin cancer. Analysis of data showed 37% of patients had sun-reactive skin type I, 27% had type II, and 36% had type III. Types IV through VI were not represented. There appeared to be an overrepresentation of types I and II. Increased melanin pigmentation may therefore be either directly or indirectly protective against the development of skin cancers in patients who have received low-dose superficial ionizing radiation for benign disease. The sun-reactive skin type of patients with chronic radiation dermatitis may be used as a predictor of skin cancer risk when the total dose of ionizing radiation is not known.

  1. Information by the German Federal Government. Environmental radioactivity and radiation exposure in 2011

    International Nuclear Information System (INIS)

    The information by the German Federal Government on environmental radioactivity and radiation exposure in 2011 includes the following issues: (I) natural radiation exposure: radiation sources; contributions to the radiation exposure (cosmic and terrestric radiation, radioactive building materials, food and drinking water, radon); assessment of the components of natural radioactivity. (II) civil radiation exposure: nuclear power plants and nuclear fuel processing plants, other nuclear facilities (interim storage plants and final repositories); summarizing assessment of nuclear facilities; environmental radioactivity from mining and remedial action in the Wismut AG; radioactive materials and ionizing radiation in research, engineering and households; residuals from industry and mining; fallout from reactor accidents and nuclear weapon testing. (III) Occupational radiation exposure: civil radiation sources, natural radiation sources (aircraft personnel, water plants, therapeutic baths). (IV) medical radiation exposure: X-ray diagnostics, nuclear medicine, radiotherapy, radiopharmaceuticals, assessment of medical radiation exposure. (V) non-ionizing radiation: electromagnetic fields, optical radiation.

  2. Magnetic resonance enterography findings of chronic radiation enteritis

    OpenAIRE

    Algin, Oktay; Turkbey, Baris; Ozmen, Evrim; Algin, Efnan

    2011-01-01

    Abstract The diagnosis of chronic radiation enteritis (CRE) is considerably challenging both for clinicians and radiologists. The aim of this study was to evaluate the role of magnetic resonance enterography (MRE) in the diagnosis of CRE. To the best of our knowledge, there are no reports on the role of MRE in the diagnosis of CRE specifically. In this report, we present MRE findings of 4 patients with CRE. The most important factors in CRE diagnosis are the clinical findings and medical hist...

  3. Assessment of occupational radiation exposure in China

    International Nuclear Information System (INIS)

    Since the eighties, the doses received by the workers of the nuclear industry system in China have been below 5 mSv, excluding uranium miners. Workers involved in the radioisotope and radiation applications received doses in the range of 1∼2 mSv. Stringent and effective measures are required to be taken for the radioisotope and radiation applications due to high accident possibility. Average annual effective doses to underground workers in variety of occupations such as uranium, coal and non-ferrous metal mines are 19.3, 8.3 and 33.2 mSv respectively on the rough estimate basis. The nuclear industry contributes only 0.17% to collective dose. Contributions by coal and non-ferrous metal mining to collective dose account for 85.15 % and 14.3% of the total respectively. The data available from coal and non-ferrous mines are less, associated with high uncertainty. (author)

  4. Radiation exposure at workplaces from radon

    International Nuclear Information System (INIS)

    The measuring campaign for the survey was performed in compliance with the EURATOM Basic Safety Standards for the protection of the general public and workers against the dangers of ionizing radiation. The campaign started with measurements at underground workplaces, i.e. in mines, developed mines open for visitors, and developed commercial caves, and continued with scanning the spas in Germany and the relevant balneotherapeutical places. Scanning activities in the drinking water conditioning plants of the Land of Baden-Wuerttemberg are heading towards completion. Approximately 400 places have been scanned so far for their radiological conditions emanating from the presence of radon, radon daughter products, and direct radiation. The statistical survey derived from the measured data presents a reliable source of reference indicating any need for initiating protective measures in the event of maximum permissible levels or levels for intervention being adopted. (orig.)

  5. Temperature modulates phototrophic periphyton response to chronic copper exposure.

    Science.gov (United States)

    Lambert, Anne Sophie; Dabrin, Aymeric; Morin, Soizic; Gahou, Josiane; Foulquier, Arnaud; Coquery, Marina; Pesce, Stéphane

    2016-01-01

    Streams located in vineyard areas are highly prone to metal pollution. In a context of global change, aquatic systems are generally subjected to multi-stress conditions due to multiple chemical and/or physical pressures. Among various environmental factors that modulate the ecological effects of toxicants, special attention should be paid to climate change, which is driving an increase in extreme climate events such as sharp temperature rises. In lotic ecosystems, periphyton ensures key ecological functions such as primary production and nutrient cycling. However, although the effects of metals on microbial communities are relatively well known, there is scant data on possible interactions between temperature increase and metal pollution. Here we led a study to evaluate the influence of temperature on the response of phototrophic periphyton to copper (Cu) exposure. Winter communities, collected in a 8 °C river water, were subjected for six weeks to four thermal conditions in microcosms in presence or not of Cu (nominal concentration of 15 μg L(-1)). At the initial river temperature (8 °C), our results confirmed the chronic impact of Cu on periphyton, both in terms of structure (biomass, distribution of algal groups, diatomic composition) and function (photosynthetic efficiency). At higher temperatures (13, 18 and 23 °C), Cu effects were modulated. Indeed, temperature increase reduced Cu effects on algal biomass, algal class proportions, diatom assemblage composition and photosynthetic efficiency. This reduction of Cu effects on periphyton may be related to lower bioaccumulation of Cu and/or to selection of more Cu-tolerant species at higher temperatures. PMID:26608872

  6. Basis for limiting exposure to ionizing radiation

    International Nuclear Information System (INIS)

    In view of the uncertainty about the size of the risk from radiation, it is assumed that all doses are potentially harmful with the probability of harm proportional to the dose, without threshold. Canada participates in the work of UNSCEAR, and the Canadian Atomic Energy Control Board follows the recommendations of the International Commission on Radiological Protection in setting its dose limits, encouraging the application of the ALARA (as low as reasonably achievable) concept through its licensing and compliance activities

  7. Telomere Length in Aged Mayak PA Nuclear Workers Chronically Exposed to Internal Alpha and External Gamma Radiation.

    Science.gov (United States)

    Scherthan, Harry; Sotnik, Natalia; Peper, Michel; Schrock, Gerrit; Azizova, Tamara; Abend, Michael

    2016-06-01

    Telomeres consist of GC-rich DNA repeats and the "shelterin" protein complex that together protect chromosome ends from fusion and degradation. Telomeres shorten with age due to incomplete end replication and upon exposure to environmental and intrinsic stressors. Exposure to ionizing radiation is known to modulate telomere length. However, the response of telomere length in humans chronically exposed to radiation is poorly understood. Here, we studied relative telomere length (RTL) by IQ-FISH to leukocyte nuclei in a group of 100 workers from the plutonium production facility at the Mayak Production Association (PA) who were chronically exposed to alpha-emitting ((239)Pu) radiation and/or gamma (photon) radiation, and 51 local residents serving as controls, with a similar mean age of about 80 years. We applied generalized linear statistical models adjusted for age at biosampling and the second exposure type on a linear scale and observed an age-dependent telomere length reduction. In those individuals with the lowest exposure, a significant reduction of about 20% RTL was observed, both for external gamma radiation (≤1 Gy) and internal alpha radiation (≤0.05-0.1 Gy to the red bone marrow). In highly exposed individuals (>0.1 Gy alpha, 1-1.5 Gy gamma), the RTL was similar to control. Stratification by gender revealed a significant (∼30%) telomere reduction in low-dose-exposed males, which was absent in females. While the gender differences in RTL may reflect different working conditions, lifestyle and/or telomere biology, absence of a dose response in the highly exposed individuals may reflect selection against cells with short telomeres or induction of telomere-protective effects. Our observations suggest that chronic systemic exposure to radiation leads to variable dose-dependent effects on telomere length. PMID:27340887

  8. Review of retrospective dosimetry techniques for external ionising radiation exposures

    International Nuclear Information System (INIS)

    The current focus on networking and mutual assistance in the management of radiation accidents or incidents has demonstrated the importance of a joined-up approach in physical and biological dosimetry. To this end, the European Radiation Dosimetry Working Group 10 on 'Retrospective Dosimetry' has been set up by individuals from a wide range of disciplines across Europe. Here, established and emerging dosimetry methods are reviewed, which can be used immediately and retrospectively following external ionising radiation exposure. Endpoints and assays include dicentrics, translocations, premature chromosome condensation, micronuclei, somatic mutations, gene expression, electron paramagnetic resonance, thermoluminescence, optically stimulated luminescence, neutron activation, haematology, protein biomarkers and analytical dose reconstruction. Individual characteristics of these techniques, their limitations and potential for further development are reviewed, and their usefulness in specific exposure scenarios is discussed. Whilst no single technique fulfils the criteria of an ideal dosemeter, an integrated approach using multiple techniques tailored to the exposure scenario can cover most requirements. (authors)

  9. Radiation exposure in Japan and evaluation of the health hazards

    International Nuclear Information System (INIS)

    One year after the fission product release from the NPP Fukushima Daiichi as a consequence of the earthquake and tsunami in March 2011 the World Health Organization (WHO) has published an extensive estimation of the radiation exposure of the public. Models for the resulting health hazards were developed. The United Nations scientific committee on the effects of atomic radiation (UNSCEAR) has actualized the radiation exposure based on new data. The contribution summarizes the aspects of these reports. According to these reports the early evacuation of the habitants and the dose limits for food contamination has kept the public exposure on a low level. The uncertainties of the simulations concerning the resulting health hazards are high.

  10. Factors impacting public acceptance of medical radiation exposure

    International Nuclear Information System (INIS)

    We undertook a survey to determine the public acceptance of medical radiation exposure throughout Japan, and 1,357 responses (67.9% response rate) were obtained using a two-stage systematic stratified random sampling method. The acceptance of exposure of children was generally similar to that of adults. For each of the attributes, 45-60% of the participants were accepting of exposure for cancer treatment and diagnosis, but only 30% were accepting of exposure for X-ray diagnoses of bone fractures and dental caries. In general, the presence of a child did not markedly affect women's acceptance of exposure. Factor analyses identified 3 factors influencing the acceptance of child exposure: symptomatic diseases to determine treatment, the possibility of high-risk diseases (or major organ diseases), and the association with cancer. Cluster analysis showed 4 clusters: a positive group regarding children's exposure for the diagnosis of bone fractures and dental caries (12.9% of all participants), a positive group for major organ disease and cancer (15.5%), a negative group excluding cancer (55.2%), and a positive group for all cases (16.4%). The cluster distributions revealed that mothers with 10- to 18-year-old firstborn children showed a tendency to accept the medical radiation exposure of their children in all cases. (author)

  11. Cover-up of the effects of internal exposure by residual radiation from the atomic bombing of Hiroshima and Nagasaki.

    Science.gov (United States)

    Sawada, Shoji

    2007-01-01

    The criteria certifying atomic bomb disease adopted by the Japanese government are very different from the actual state of the survivors. The criteria are based on epidemiological research by the Radiation Effects Research Foundation, the successor to the Atomic Bomb Casualty Commission (ABCC). The ABCC studied only the effects of primary radiation from the atomic bombing on the survivors of Hiroshima and Nagasaki, and ignored the damage from residual radiation. Analysis of the incidence of acute radiation disease, the rate of chromosomal aberrations, and the relative risks of chronic disease among the survivors, shows that the effects of residual radiation from fallout exceeds that of primary radiation in the area more than 1.5-1.7 km distant from the hypocentre of the Hiroshima bombing. The effects of internal exposure due to intake of tiny radioactive particles are more severe than those of external exposure, explaining the difference between the official criteria and the actual state of the survivors. PMID:17370859

  12. The ionising radiation (medical exposure) regulations - IR (ME) R, Malta

    International Nuclear Information System (INIS)

    Full text: The regulations in Malta at present are in draft stage. These regulations partially implement European Council Directive 97/43/Euratom. This Directive lays down the basic measurements for the health and protection of individuals against dangers of ionising radiation in relation to medical exposure. The regulations impose duties on persons administering radiations, to protect people from unnecessary exposure whether as part of their own medical diagnosis, treatment or as part of occupational health worker for health screening, medico-legal procedures, voluntary participation in research etc. These regulations also apply to individuals who help other individuals undergoing medical exposure. Main provisions 1. Regulation 2 contains the definitions of 28 terms used in these regulations. 2. Regulation 3.1 and 3.2 sets out the medical exposures to which the regulations apply. 3. Regulation 4 requires approval of medical exposures due to medical research, from radiation protection board of Malta. 4. Regulation 5 prohibits new procedures involving medical exposure unless it has been justified in advance. 5. Regulation 6 provides conditions justifying medical exposures. It prohibits any medical exposure from being carried out which has not been justified and authorized and sets out matters to be taken into account for justification. 6. Regulation 7 requires that practitioner justifies the exposure, shall pay special attention towards (a) exposure from medical research procedures where there is no direct health benefit to the individual undergoing exposure, (b) exposures for medico-legal purposes; (c) exposures to pregnant or possible pregnant women and (d) exposures to breast-feeding women. 7. Regulation 8.1 to 8.3 prohibit any medical exposure from being carried out which has not been justified and sets out matters to be taken for justification 8. Regulation 8.4 prohibits an exposure if it cannot be justified. 9. Regulation 9 requires the employer to provide a

  13. Radiation exposure in nuclear medicine: real-time measurement

    OpenAIRE

    Sylvain Iara; Bok Bernard

    2002-01-01

    French regulations have introduced the use of electronic dosimeters for personal monitoring of workers. In order to evaluate the exposure from diagnostic procedures to nuclear medicine staff, individual whole-body doses were measured daily with electronic (digital) personal dosimeters during 20 consecutive weeks and correlated with the work load of each day. Personal doses remained always below 20 µSv/d under normal working conditions. Radiation exposure levels were highest to tech staff, nur...

  14. Sub-chronic exposure to second hand smoke induces airspace leukocyte infiltration and decreased lung elastance

    OpenAIRE

    Hartney, John M.; Chu, HongWei; Pelanda, Roberta; Torres, Raul M.

    2012-01-01

    Exposure to second hand tobacco smoke is associated with the development and/or exacerbation of several different pulmonary diseases in humans. To better understand the possible effects of second hand smoke exposure in humans, we sub-chronically (4 weeks) exposed mice to a mixture of mainstream and sidestream tobacco smoke at concentrations similar to second hand smoke exposure in humans. The inflammatory response to smoke exposures was assessed at the end of this time by enumeration of pulmo...

  15. Effects of Chronic Manganese Exposure on Cognitive and Motor Functioning in Non-Human Primates

    OpenAIRE

    Schneider, Jay S.; Decamp, Emmanuel; Koser, Amy Jo; Fritz, Stephanie; Gonczi, Heather; Syversen, Tore; Guilarte, Tomás R.

    2006-01-01

    Acute exposure to manganese is associated with complex behavioral/psychiatric signs that may include Parkinsonian motor features. However, little is known about the behavioral consequences of chronic manganese exposures. In this study, cynomolgus macaque monkeys were exposed to manganese sulfate (10 –15 mg/kg/week) over an exposure period lasting 272 ± 17 days. Prior to manganese exposure, animals were trained to perform tests of cognitive and motor functioning and overall behavior was assess...

  16. Low Magnitude Occupational Radiation Exposures Are They Safe or Unsafe

    International Nuclear Information System (INIS)

    Man has always been exposed to ionizing radiation from natural sources and background exposure varies with the locations. No deleterious effects have been uniquely correlated, either they are not produced at low levels of exposure or their frequency is too low to be statistically observable. Direct source of information on radiation hazards in man is obviously based on follow up of population groups exposed to certain levels of radiation. Harmful effects of ionizing radiations are traced to documented exposures; for radiologists during 1920 s and 30 s, miners exposed to airborne radioactivity, workers in the radium industry, follow-up data of Japanese nuclear bomb survivors of Hiroshima and Nagasaki, the Marshallese accident in 1954, and the victims of the limited number of accidents at nuclear installations including Chernobyl. Mostly these information are from situations involving higher doses and dose rates. Ionizing radiations have been used extensively on the peaceful applications of atomic energy in general and medical applications in particular have shown to outweigh benefits over the risks. Personnel, low magnitude of exposures are encountered during routine work in handling radiation sources. In the light of present knowledge there is need to reassess the quantum of actual risk instead of projected risk based on long time models. The United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) described models for dose-response relationships and micro-dosimetric arguments for defining low doses. The definition of low doses could also be based on direct observations in experimental or epidemiological studies. Through measurement of cell damage or death using human lymphocytes, linear and quadratic terms have been fitted the response and low doses have been judged to be 20-40 mSv. Data derived from epidemiological studies, mainly the atomic bomb survivors, suggests that for solid tumours and leukaemia, 200 mSv could be considered the

  17. Radiation exposures for DOE and DOE contractor employees, 1990

    International Nuclear Information System (INIS)

    This is the 23rd in a series of annual radiation exposure reports published by the Department of Energy (DOE) or its predecessors. This report summarizes the radiation exposures received by both employees and visitors at DOE and DOE contractor facilities during 1990. Trends in radiation exposures are evaluated by comparing the doses received in 1990 to those received in previous years. The significance of the doses is addressed by comparing them to the DOE limits and by correlating the doses to health risks based on risk estimated from expert groups. This report is the third that is based on detailed exposure data for each individual monitored at a DOE facility. Prior to 1988, only summarized data from each facility were available. This report contains information on different types of radiation doses, including total effective, internal, penetrating, shallow, neutron, and extremity doses. It also contains analysis of exposures by age, sex, and occupation of the exposed individuals. This report also continues the precedent established in the Twenty-First (1988) Annual Report by conducting a detailed, one-time review and analysis of a particular topic of interest. The special topic for this report is a comparison of total effective, internal, and extremity dose equivalent values against penetrating dose equivalent values

  18. Reduction in radiation exposure and volume using asphalt solidification

    International Nuclear Information System (INIS)

    The solidification of liquid and solid radioactive wastes from nuclear power plants with an extruder-evaporator using an asphalt binder minimizes both volume and radiation exposure. The automatic evaporation of water in liquid radwastes prior to incorporation into asphalt reduces the volume to be transported and disposed. In turn, the numbers of drums requiring handling is reduced 5 to 10 times thereby lessening the chances for radiation exposure. Also, the extruder-evaporator is self-shielded and contains only about one gallon of the radwaste. Dose rates at the surface of the equipment and filled containers from commercially operating systems for the past 10 years in Europe are given

  19. Radiation exposure of sand blasting operators

    International Nuclear Information System (INIS)

    The Queensland Department of Health's, Division of Health and Medical Physics initiated, in July, 1985, an investigation into the radiological health impact which involved detailed analyses of an ilmenite product from a mineral sand processor in South East Queensland. Measurements of respirable dust in air concentrations in the breathing zone of sand blasting operators, dust particle sizing and other environmental radiation measurements at a major sand blasting yard using this ilmenite product were carried out. From the data collected, the radiological health impact was assessed and compared with international and national radiological recommendations

  20. Limitation of exposure to ionizing radiation

    International Nuclear Information System (INIS)

    The Atomic Energy Control Board (AECB) proposes to amend the Atomic Energy Control Regulations in the light of the latest recommendations of the International Commission on Radiological Protection (ICRP). Guidance on how the AECB would apply its proposed amended regulations is provided in this document, which also explains the more important changes from the present regulations. The most basic change is the introduction of the concept of effective dose equivalent. Another is a requirement to keep doses of radiation as low as reasonably achievable. (L.L.)

  1. Pregnancy and exposure to ionizing radiations

    International Nuclear Information System (INIS)

    The sensitivity of the embryo and foetus varies during pregnancy. Recent studies confirm that the principal damage is mental retardation. It is generally admitted that the risk is negligible for a dose 200 mSv.The objective of this work is to provide precise information on the various risks related to the irradiation for the foetus, according to the age of gestation and delivered dose, and the action to be taken in case of accidental irradiation. The medical use of ionizing radiation in pregnant women can only be considered within the framework of precise information. (author)

  2. Radiation exposure and human species survival

    International Nuclear Information System (INIS)

    Information available from scientific sources without vested interests in the use of radiation is examined in the hope of elucidating the probable long-term effects on the human species of widespread radionuclide contamination. Distinguishing between problems of nuclear war, catastrophic accident in a nuclear industry, waste disposal, terrorist action, periodic accident situations and routine so-called normal pollution seems fruitless as these differ only in degree of pollution per time period. If there is indeed a species death process involved, the rate of deterioration will depend on the rate of pollution, but the result will be the same

  3. Angiographer's exposure to radiation under different fluoroscopic imaging conditions

    International Nuclear Information System (INIS)

    Scattered radiation levels near an imaging system commonly used in angiography were measured with a 200 mm thick water phantom. The scattered radiation exposure rate was measured in lines parallel in space to the central ray of the x-ray beam, at lateral distances of 30-100 cm. The effects of an x-ray beam limiting device, geometric and electric magnification, and rotation angle of the C-arm were also determined. The results indicated that the highest scattered radiation levels occurred near the surface of the phantom where the x-ray beam enters. In P-A geometry, the highest radiation levels occurred below the angiographer's waist. These areas of the body corresponded to the gonads of the angiographer. It has been suggested that angiographers' exposure rates are higher near the gonads than near the chest. However, lead aprons efficiently protect these areas. When smaller field sizes were limited by a variable x-ray beam limiting device, the volume of irradiated tissue was reduced, and the scattered radiation exposure rate was decreased. Further, when larger magnification factors were chosen for the analogue magnification method, the volume of irradiated tissue was reduced by the automatic x-ray beam limiting device, and the scattered radiation exposure rate was decreased. However, smaller field sizes markedly increased patient exposure by auto brightness control. To mitigate the angiographer's exposure, smaller field sizes with x-ray limiting devices are required. However, a larger field size should be used whenever possible to minimize patient exposure. The angiographer's exposure rate was influenced by the incidence direction of the x-ray beam when the C-arm had been rotated around the phantom. Consequently, the angiographer's exposure rate was maximum when the x-ray tube most closely approached the angiographer and was minimum when the image intensifier most closely approached the angiographer. Therefore, to mitigate the angiographer's exposure, attention needs

  4. The effects of acute radiation exposure on the serum components

    International Nuclear Information System (INIS)

    The blood samples were collected from the experimental animals 24 hrs after irradiation of gamma doses upto 80 Gy. Native PAGE showed a decreasing trend in gamma globulin fraction of serum from the irradiated group compared to control, while SDS PAGE indicated an enhanced tendency in protein of molecular weight 30,000 to 40,000. Serum albumin slightly decreased with radiation doses as a result of decrease in total protein amount. Radiation exposure had little or no effects on such lipid related components as phospholipid, triglyceride, and cholesterol, respectively. Among others, glutamic pyryvic transaminase (GPT) showed a drastic decrease in its amount 24 hrs after radiation exposure, which can be applied to the health care program for radiation workers. (Author)

  5. Risk Assessment of Radiation Exposure using Molecular Biodosimetry

    Science.gov (United States)

    Elliott, Todd F.; George, K.; Hammond, D. K.; Cucinotta, F. A.

    2007-01-01

    Current cytogenetic biodosimetry methods would be difficult to adapt to spaceflight operations, because they require toxic chemicals and a substantial amount of time to perform. In addition, current biodosimetry techniques are limited to whole body doses over about 10cGy. Development of new techniques that assess radiation exposure response at the molecular level could overcome these limitations and have important implications in the advancement of biodosimetry. Recent technical advances include expression profiling at the transcript and protein level to assess multiple biomarkers of exposure, which may lead to the development of a radiation biomarker panel revealing possible fingerprints of individual radiation sensitivity. So far, many biomarkers of interest have been examined in their response to ionizing radiation, such as cytokines and members of the DNA repair pathway. New technology, such as the Luminex system can analyze many biomarkers simultaneously in one sample.

  6. A relational database for personnel radiation exposure management

    International Nuclear Information System (INIS)

    In-house utility personnel developed a relational data base for personnel radiation exposure management computer system during a 2 1/2 year period. The (PREM) Personnel Radiation Exposure Management System was designed to meet current Nuclear Regulatory Commission (NRC) requirements related to radiological access control, Radiation Work Permits (RWP) management, automated personnel dosimetry reporting, ALARA planning and repetitive job history dose archiving. The system has been operational for the past 18 months which includes a full refueling outage at Clinton Power Station. The Radiation Protection Department designed PREM to establish a software platform for implementing future revisions to 10CFR20 in 1993. Workers acceptance of the system has been excellent. Regulatory officials have given the system high marks as a radiological tool because of the system's ability to track the entire job from start to finish

  7. Cumulative radiation exposure in children with cystic fibrosis.

    LENUS (Irish Health Repository)

    O'Reilly, R

    2010-02-01

    This retrospective study calculated the cumulative radiation dose for children with cystic fibrosis (CF) attending a tertiary CF centre. Information on 77 children with a mean age of 9.5 years, a follow up time of 658 person years and 1757 studies including 1485 chest radiographs, 215 abdominal radiographs and 57 computed tomography (CT) scans, of which 51 were thoracic CT scans, were analysed. The average cumulative radiation dose was 6.2 (0.04-25) mSv per CF patient. Cumulative radiation dose increased with increasing age and number of CT scans and was greater in children who presented with meconium ileus. No correlation was identified between cumulative radiation dose and either lung function or patient microbiology cultures. Radiation carries a risk of malignancy and children are particularly susceptible. Every effort must be made to avoid unnecessary radiation exposure in these patients whose life expectancy is increasing.

  8. Radiation exposure dose on persons engaged in radiation-related industries in Korea

    International Nuclear Information System (INIS)

    This study investigated the status of radiation exposure doses since the establishment of the 'Regulations on Safety Management of Diagnostic Radiation Generation Device' in January 6, 1995. The level of radiation exposure in people engaged or having been engaged in radiation-related industries of inspection organizations, educational organization, military units, hospitals, public health centers, businesses, research organizations or clinics over a 5 year period from Jan. 1, 2000 to Dec. 31, 2004 was measured. The 149,205 measurement data of 57,136 workers registered in a measurement organization were analysed in this study. Frequency analysis, a Chi-square test, Chi-square trend test, and ANOVA was used for data analysis. Among 57,136 men were 40,870 (71.5%). 50.3% of them were radiologic technologists, otherwise medical doctors (22.7%), nurse (2.9%) and others (24.1%). The average of depth radiation and surface radiation during the 5-year period were found to decrease each year. Both the depth radiation and surface radiation exposure were significantly higher in males, in older age groups, in radiological technologists of occupation. The departments of nuclear medicine had the highest exposure of both depth and surface radiation of the divisions of labor. There were 1.98 and 2.57 per 1,000 person-year were exposed more than 20 mSv (limit recommended by International Commission on Radiological Protection) in depth and surface radiation consequently. The total exposure per worker was significantly decreased by year. But Careful awareness is needed for the workers who exposed over 20 mSv per year. In order to minimize exposure to radiation, each person engaged in a radiation-related industry must adhere to the individual safety management guidelines more thoroughly. In addition, systematic education and continuous guidance aimed at increasing the awareness of safety must be provided

  9. Evaluation of medical radiation exposure in pediatric interventional radiology procedures

    Energy Technology Data Exchange (ETDEWEB)

    Navarro, Valeria Coelho Costa; Navarro, Marcus Vinicius Teixeira; Oliveira, Aline da Silva Pacheco, E-mail: vccnavarro@gmail.com [Instituto Federal de Educacao, Ciencia e Tecnologia da Bahia (IFBA), Salvador, BA (Brazil); Maia, Ana Figueiredo [Universidade Federal de Sergipe (UFS), Aracaju, SE (Brazil); Oliveira, Adriano Dias Dourado [Sociedade Brasileira de Hemodinamica e Cardiologia Intervencionista, Salvador, BA (Brazil)

    2012-07-15

    Objective: To evaluate pediatric radiation exposure in procedures of interventional radiology in two hospitals in the Bahia state, aiming at contributing to delineate the scenario at the state and national levels. The knowledge of exposure levels will allow an evaluation of the necessity of doses optimization, considering that peculiarities of radiology and pediatrics become even more significant in interventional radiology procedures which involve exposure to higher radiation doses. Materials and Methods: A total of 32 procedures were evaluated in four rooms of the two main hospitals performing pediatric interventional radiology procedures in the Bahia state. Air kerma rate and kerma-area product were evaluated in 27 interventional cardiac and 5 interventional brain procedures. Results: Maximum values for air kerma rate and kerma-area product and air kerma obtained in cardiac procedures were, respectively, 129.9 Gy.cm{sup 2} and 947.0 mGy; and, for brain procedures were 83.3 Gy.cm{sup 2} and 961.0 mGy. Conclusion: The present study results showed exposure values up to 14 times higher than those found in other foreign studies, and approximating those found for procedures in adults. Such results demonstrate excessive exposure to radiation, indicating the need for constant procedures optimization and evaluation of exposure rates. (author)

  10. Exposure of pregnant women to ionizing radiation in hospitals

    International Nuclear Information System (INIS)

    Occupational health physicians often face the problem of whether to keep pregnant women at work in hospitals where they risk exposure to ionizing radiation. Current legislation requires that doctors ensure a certain level of safety for the embryo and the fetus. The current rules are unsatisfactory, however, because women are not obliged to declare that they are pregnant until the third month, which is one month past the period when he fetus is most sensitive to ionizing radiation. (author). 15 refs

  11. Evaluation of diseases associated to occupational exposure to ionizing radiations

    International Nuclear Information System (INIS)

    A retrospective investigation of all cases of radiation workers with diseases and injuries, considered as occupational diseases caused by ionizing radiation is presented. The investigation includes all cases registered in the Institute of Occupational Health over five years period (1990-1995). The incidence of that diseases are studied, as well as the correlation between each type of source, time of exposure and annual average equivalent individual dose

  12. Effects of chronic uranium internal exposure on mortality: Results of a pilot study among French nuclear workers

    International Nuclear Information System (INIS)

    Background: This article presents the mortality data compiled among a cohort of workers at risk of internal uranium exposure and discusses the extent to which this exposure might differentiate them from other nuclear workers. Methods: The cohort consisted of 2897 Areva-NC-Pierrelatte plant workers, followed from 1 January 1968 through 31 December 2006 (79,892 person-years). Mortality was compared with that of the French population, by calculating Standardized Mortality Ratios (SMR) and 95 % confidence intervals (CI95 %). External radiation exposure was reconstructed using external dosimetry archives. Internal uranium exposure was assessed using a plant-specific job-exposure-matrix, considering six types of uranium compounds according to their nature (natural and reprocessed uranium [RPU] and solubility [fast-F, moderate-M, and slow-S]). Exposure-effect analyses were performed for causes of death known to be related to external radiation exposure (all cancers and circulatory system diseases) and cancer of uranium target-organs (lung and hematopoietic and lymphatic tissues, HLT). Results: A significant deficit of mortality from all causes (SMR = 0.58; CI95% [0.53-0.63]), all cancers (SMR = 0.72; CI95% [0.63-0.82]) and smoking related cancers was observed. Non-significant 30 %-higher increase of mortality was observed for cancer of pleura (SMR = 2.32; CI95% [0.75-5.41]), rectum and HLT, notably non-Hodgkin's lymphoma (SMR = 1.38; CI95% [0.63-2.61]) and chronic lymphoid leukemia (SMR = 2.36; CI95% [0.64-6.03]). No exposure-effect relationship was found with external radiation cumulative dose. A significant exposure-effect relationship was observed for slowly soluble uranium, particularly RPU, which was associated with an increase in mortality risk reaching 8 to 16 % per unit of cumulative exposure score and 10 to 15 % per year of exposure duration. Conclusion: The Areva-NC-Pierrelatte workers cohort presents a non-significant over-mortality from HLT cancers, notably of

  13. Biomarkers for assessing potential carcinogenic effects of chronic arsenic exposure in Inner Mongolia, CHINA

    Science.gov (United States)

    Arsenic is ubiquitous in the environment. Chronic arsenic exposure via drinking water has been associated. with carcinogenic, cardiovascular, neurological and diabetic effects in humans and has been of great public health concern worldwide. In 2001, U.S. Environmental Protection ...

  14. Environmental radiation exposure: Regulation, monitoring, and assessment

    International Nuclear Information System (INIS)

    Radioactive releases to the environment from nuclear facilities constitute a public health concern. Protecting the public from such releases can be achieved through the establishment and enforcement of regulatory standards. In the United States, numerous standards have been promulgated to regulate release control at nuclear facilities. Most recent standards are more restrictive than those in the past and require that radioactivity levels be as low as reasonably achievable (ALARA). Environmental monitoring programs and radiological dose assessment are means of ensuring compliance with regulations. Environmental monitoring programs provide empirical information on releases, such as the concentrations of released radioactivity in environmental media, while radiological dose assessment provides the analytical means of quantifying dose exposures for demonstrating compliance

  15. Radiation exposure levels in phosphate mining activities

    International Nuclear Information System (INIS)

    Radon, radon daughter concentration and gamma ray exposure rate were measured at different places in the phosphate mining areas of Syria. The grab sampling method was used. For radon measurements, discrete air samples without progeny were collected over short periods of time, whereas daughters were collected on filter paper. A three-count procedure was used for the measurement of radon daughter concentrations to improve accuracy. The measurements were carried out at 37 locations selected in the mines, factories, offices and homes in the mining area. The sampling was repeated monthly for a full calendar year. Workers and their families were classified in different categories according to the nature of their jobs. The doses were estimated using proper occupancy factors. The dose equivalent from radon daughters varies from 1 mSv.y-1 to a maximum of 10 mSv.y-1. Radon concentrations vary from 100 Bq.m-3 to several hundreds. (author)

  16. Safety of natural radiation exposure. A meta-analysis of epidemiological studies on natural radiation

    International Nuclear Information System (INIS)

    People have been exposed every time and everywhere to natural radiation and ''intuitively'' know the safety of this radiation exposure. On the other hand the theory of no threshold value on radiological carcinogenesis is known widely, and many people feel danger with even a smallest dose of radiation exposure. The safety of natural radiation exposure can be used for the risk communication with the public. For this communication, the safety of natural radiation exposure should be proved ''scientifically''. Safety is often discussed scientifically as the risks of the mortality from many practices, and the absolute risks of safe practices on the public are 1E-5 to 1E-6. The risks based on the difference of natural radiation exposure on carcinogenesis have been analyzed by epidemiological studies. Much of the epidemiological studies have been focused on the relationship between radiation doses and cancer mortalities, and their results have been described as relative risks or correlation factors. In respect to the safety, however, absolute risks are necessary for the discussion. Cancer mortalities depend not only on radiation exposure, but also on ethnic groups, sexes, ages, social classes, foods, smoking, environmental chemicals, medical radiation, etc. In order to control these confounding factors, the data are collected from restricted groups or/and localities, but any these ecological studies can not perfectly compensate the confounding factors. So positive or negative values of relative risks or the meaningful correlation factors can not be confirmed that their values are derived originally from the difference of their exposure doses. The absolute risks on these epidemiological studies are also affected by many factors containing radiation exposure. The absolute risk or the upper value of the confidence limit obtained from the epidemiological study which is well regulated confounding factors is possible to be a maximum risk on the difference of the exposure doses

  17. Monitoring Of Radiation Exposure Source In PPTA Serpong

    International Nuclear Information System (INIS)

    The radiation exposure in the of P PTA Serpone was measured by means of MCA micro nomad. The computer codes NAGABAT was used for analyzing the contribution of natural gamma rays to the exposure rate in the measuring locations. Measurement was taken for 14 locations, under conditions that the nuclear facilities are not in operation. The result showed that the exposure varieties, dependently on potassium, uranium and thorium contents in the environment matrix. The maximum of thorium, uranium and potassium are in amount of 5,269 ppm; 1,650 ppm; and respectively 0,72 %

  18. Radiation exposure to the child during cardiac catheterization

    International Nuclear Information System (INIS)

    Few data are available regarding radiation exposure to children during cardiac catheterization. Using lithium fluoride thermoluminescent dosimeters, radiation exposure was measured during precatheterization chest roentgenography, fluoroscopy (hemodynamic assessment phase of catheterization) and cineangiography in 30 infants and children, ages 3 days to 21 years. Dosimeters were placed over the eyes, thyroid, anterior chest, posterior chest, anterior abdomen, posterior abdomen and gonads. Average absorbed chest doses were 24.5 mR during chest roentgenography, 5810 mR during catheterization fluoroscopy and 1592 mR during cineangiography. During the complete catheterization, average doses were 26 mR to the eyes, 431 mR to the thyroid area, 150 mR to the abdomen and 11 mR to the gonads. Radiation exposure during pediatric cardiac catheterization is low to the eyes and gonads but high to the chest and thyroid area. To decrease radiation dosage we suggest (1) low pulse-rate fluoroscopy; (2) substitution of contrast echocardiography for cineangiography; (3) large-plate abdominal/gonadal shielding; (4) a selective shield for thyroid area; (5) a very small field during catheter manipulation. Minimum radiation consistent with accurate diagnosis is optimal; however, erroneous or incomplete diagnosis is more dangerous than radiation-related hazards

  19. Efeitos da radiação solar crônica prolongada sobre o sistema imunológico de pescadores profissionais em Recife (PE, Brasil Effects of long-term chronic exposure to sun radiation in immunological system of commercial fishermen in Recife, Brazil

    Directory of Open Access Journals (Sweden)

    Sarita Maria de Fátima Martins de Carvalho Bezerra

    2011-04-01

    Full Text Available FUNDAMENTOS: Existe um consenso de que a exposição à radiação ultravioleta determina alterações n o sistema imunológico da pele, o que permite que se avente a hipótese de que a exposição prolongada e crônica ao Sol pode representar uma das maiores agressões ambientais à saúde humana. Entre as várias ocupações que requerem, necessariamente, exposição prolongada e crônica ao Sol está a de pescador. No entanto, a experiência clínica dermatológica, amealhada ao longo de vários anos de exercício da Medicina, não parece confirmar essa hipótese. OBJETIVO: Avaliar efeitos clínicos, histológicos e imunológicos da exposição crônica e prolongada à radiação ultravioleta em pescadores. MÉTODOS: Em estudo prospectivo, transversal, observacional, foram caracterizadas lesões dermatológicas, marcadores imunológicos e alterações histológicas de pescadores e subpopulações de linfócitos comparadas a grupo-controle. Empregaram-se testes de Mann-Whitney, exato de Fisher, Wilcoxon em nível de 0,05. RESULTADOS: Houve diferenças entre os grupos exposto e protegido em elastose (p = 0,03, ectasia de vasos dérmicos (p = 0,012 e número de células nas camadas epidérmicas entre os cones (p = 0,029. Foram mais comuns em pescadores CD45RO, CD68+ e mastócitos na pele (p = 0,040, p BACKGROUND: Among the various occupations which necessarily require long-term and chronic sun exposure is that of a fisherman. However, clinical experience in dermatology earned over several years of medical practice does not seem to confirm this hypothesis. OBJECTIVE: To evaluate clinical, histological and immunological effects of long-term and chronic exposure to ultraviolet radiation in fishermen. METHODS: A prospective, cross-sectional and observational study characterized skin lesions, immunological markers and histological alterations in fishermen, as well as lymphocyte subpopulations compared to a control group. Mann-Whitney, Fisher's and

  20. The Impact of Chronic Pesticide Exposure on Neuropsychological Functioning

    Science.gov (United States)

    Schultz, Caitlin G.; Ferraro, F. Richard

    2013-01-01

    This study compared neuropsychological test performance of individuals (n = 18) with an occupational history of pesticide exposure to individuals (n = 35) with no such exposure history. Results showed that a history of pesticide-related occupation exposure led to deficits in only Digit Symbol performance. Additionally, the correlation between…

  1. Occupational radiation exposure experience: Paducah Gaseous Diffusion Plant

    International Nuclear Information System (INIS)

    The potential for significant uranium exposure in gaseous diffusion plants is very low. The potential for significant radiation exposure in uranium hexafluoride manufacturing is very real. Exposures can be controlled to low levels only through the cooperation and commitment of facility management and operating personnel. Exposure control can be adequately monitored by a combination of air analyses, urinalyses, and measurements of internal deposition as obtained by the IVRML. A program based on control of air-borne uranium exposure has maintained the internal dose of the Paducah Gaseous Diffusion Plant workman to less than one-half the RPG dose to the lung (15 rem/year) and probably to less than one-fourth that dose

  2. Radiation exposure distribution in patients undergoing CT brain scans

    International Nuclear Information System (INIS)

    The distribution of surface exposures in patients undergoing single and multiple computerized tomographic brain scans with Hitachi CT-W500 was measured by LiF(Mg, Ti) thermoluminescent dosimetry. It was found that there was no significant difference in the sufrace exposures from different scanning slices. However, the exposure doses at different scanning angles around the head were different significantly. The reference point of the maximum surface exposure was at the temporal part of the head. the maximum surface exposure was at 1.65 x 10-3 C·kg-1 while the average exposure was 1.55 x 10-3 C·kg-1. The ratio of the average dose resulting from nine scans to that from a single scan was 1.3, and the surface exposure contribution of scattered radiation was computed. At the same time the radiation doses to eyes, thyroid, chest and gonads of patiens at corresponding position were also measured and were compared with those from CT cranial scans in children and skull radiographic procedures respectively

  3. Radiation exposures to technologists from nuclear medicine imaging procedures

    International Nuclear Information System (INIS)

    Radiation exposures incurred by nuclear medicine technologists during diagnostic imaging and gamma camera quality control (QC) were measured on a procedural basis over a three-month period using a portable, low-range, self-reading ion chamber. A total of more than 400 measurements were made for 15 selected procedures. From these, mean procedural exposures and standard deviations were calculated. The results show that daily flood phantom QC, at 0.58 mR, and gated cardiac studies, at 0.45 mR, were the two greatest sources of exposure. Other procedures resulted in exposures varying roughly from 0.10 to 0.20 mR. Difficult patients were responsible for a doubling of technologist exposure for many procedures. Standard deviations were large for all procedures, averaging 65% of the mean values. Comparison of technologist exposure inferred from the procedural measurements with the time coincident collective dose equivalent recorded by the TLD service of the Radiation Protection Bureau indicates that approximately half of the collective technologist exposure arose from patient handling and flood QC

  4. Functional Alterations in the Dorsal Raphe Nucleus Following Acute and Chronic Ethanol Exposure

    OpenAIRE

    Lowery-Gionta, Emily G; Marcinkiewcz, Catherine A.; Kash, Thomas L.

    2014-01-01

    Alcoholism is a pervasive disorder perpetuated in part to relieve negative mood states like anxiety experienced during alcohol withdrawal. Emerging evidence demonstrates a role for the serotonin-rich dorsal raphe (DR) in anxiety following ethanol withdrawal. The current study examined the effects of chronic ethanol vapor exposure on the DR using slice electrophysiology in male DBA2/J mice. We found that chronic ethanol exposure resulted in deficits in social approach indicative of increased a...

  5. Chronic exposure of low dose salinomycin inhibits MSC migration capability in vitro

    OpenAIRE

    Scherzad, Agmal; HACKENBERG, STEPHAN; FROELICH, KATRIN; RAK, KRISTEN; HAGEN, RUDOLF; TAEGER, JOHANNES; BREGENZER, MAXIMILLIAN; KLEINSASSER, NORBERT

    2016-01-01

    Salinomycin is a polyether antiprotozoal antibiotic that is used as a food additive, particularly in poultry farming. By consuming animal products, there may be a chronic human exposure to salinomycin. Salinomycin inhibits the differentiation of preadipocytes into adipocytes. As human mesenchymal stem cells (MSC) may differentiate into different mesenchymal cells, it thus appeared worthwhile to investigate whether chronic salinomycin exposure impairs the functional properties of MSC and induc...

  6. Radiation exposure through recently developed diagnostic procedures

    International Nuclear Information System (INIS)

    Six years after the Chernobyl reactor accident up-to-date information has been made available on the contamination of affected regions in the Ukraine, White Russia and Russia that was obtained in connection with various measuring programmes. Initial reports on the increased incidence of thyroid carcinomas in children from White Russia and the Ukraine were subjected to careful scrutiny. At the Radiation Protection Meeting held at Vienna participants were made familiar with cytogenetic assays, the micronucleus test, determinations of thymidine kinase and blood cell changes as well as immunological parameters. At the same meeting, experts provided surveys of the effective doses received by patients subjected to more recently developed diagnostic procedures, among them computerized tomography, digital luminescence radiography, mammography, bone density measurements, single photon emission computerized tomography and positron emission tomography. (orig./DG)

  7. Protection of DNA damage by radiation exposure

    International Nuclear Information System (INIS)

    The SOS response of Escherichia coli is positively regulated by RecA. To examine the effects of polyamines on The SOS response of E. Coli, we investigated the expression of recA gene in polyamine-deficient mutant and wild type carrying recA'::lacZ fusion gene. As a result, recA expression by mitomycin C is higher in wild type than that of polyamine-deficient mutant, but recA expression by UV radiation is higher in wild type than of mutant. We also found that exogenous polyamines restored the recA expression in the polyamine-deficient mutant to the wild type level. These results proposed that polyamines play an important role in mechanism of intracellular DNA protection by DNA damaging agents

  8. Protection of DNA damage by radiation exposure

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jeong Ho; Kim, In Gyu; Lee, Kang Suk; Kim, Kug Chan; Oh, Tae Jung

    1998-12-01

    The SOS response of Escherichia coli is positively regulated by RecA. To examine the effects of polyamines on The SOS response of E. Coli, we investigated the expression of recA gene in polyamine-deficient mutant and wild type carrying recA'::lacZ fusion gene. As a result, recA expression by mitomycin C is higher in wild type than that of polyamine-deficient mutant, but recA expression by UV radiation is higher in wild type than of mutant. We also found that exogenous polyamines restored the recA expression in the polyamine-deficient mutant to the wild type level. These results proposed that polyamines play an important role in mechanism of intracellular DNA protection by DNA damaging agents.

  9. New houses with high radiation exposure levels

    International Nuclear Information System (INIS)

    Twenty five years ago family houses were built of slag concrete prefabricated blocks with radium concentrations from 1000 to 4000 Bq.kg-1. Dose rates of gamma radiation are 0.92x%1.36 μGy.h-1. Radon daughters concentrations 185x%1.81 Bq.m-3 are high due to low air exchange and energy saving, because the blocks have high heat penetration up to 1.9 m2K.W-1. Three quarters of these houses need remedial action. But counter measures (shielding by lead or bricks, exchange of blocks, coating walls by watersoluble polyamide resin, thermal isolation from outside and controlled ventilation, air condition) are very expensive and on top of it unacceptable to the owners. Provision of new houses are required by them. Calculation of saved health detriment supports their requirement. (author). 3 refs, 2 figs

  10. Radiological protection for medical exposure to ionizing radiation. Safety guide

    International Nuclear Information System (INIS)

    When ionizing radiation was discovered more than 100 years ago its beneficial uses were quickly discovered by the medical profession. Over the years new diagnostic and therapeutic techniques have been developed and the general level of health care has improved. This has resulted in medical radiation exposures becoming a significant component of the total radiation exposure of populations. Current estimates put the worldwide annual number of diagnostic exposures at 2500 million and therapeutic exposures at 5.5 million. Some 78% of diagnostic exposures are due to medical X rays, 21% due to dental X rays and the remaining 1% due to nuclear medicine techniques. The annual collective dose from all diagnostic exposures is about 2500 million man Sv, corresponding to a worldwide average of 0.4 mSv per person per year. There are, however, wide differences in radiological practices throughout the world, the average annual per caput values for States of the upper and lower health care levels being 1.3 mSv and 0.02 mSv, respectively. It should, however, be noted that doses from therapeutic uses of radiation are not included in these averages, as they involve very high doses (in the region of 20-60 Gy) precisely delivered to target volumes in order to eradicate disease or to alleviate symptoms. Over 90% of total radiation treatments are conducted by teletherapy or brachytherapy, with radiopharmaceuticals being used in only 7% of treatments. Increases in the uses of medical radiation and the resultant doses can be expected following changes in patterns of health care resulting from advances in technology and economic development. For example, increases are likely in the utilization of computed tomography (CT), digital imaging and, with the attendant potential for deterministic effects, interventional procedures; practice in nuclear medicine will be driven by the use of new and more specific radiopharmaceuticals for diagnosis and therapy, and there will be an increased demand for

  11. The status of the nervous system of persons exposed to occupational chronic radiation (45 years of observation)

    International Nuclear Information System (INIS)

    The retrospective study of a state of the nervous system in dynamics in 1090 workers of the first Russian atomic enterprise was carried out. The main unfavorable factor of occupational effect in the yearly years of work (1948-1954) was chronic external gamma-radiation in doses from 0.4 to 5.7 Gy per one year. During maximal radiation exposure a vegetative dystonia of a hypotensive type (51.8%), asthenic syndrome (35.2%) and syndrome of microorganic changes of the central nervous system (5.9%) were most frequently registered in workers. Frequency and the periods of the development of these syndromes depended on an annual exposure dose (p<0.001). Alongside with an occupational chronic exposure non-radiation factors (age at the moment of an exposure, initial state of health, intense nature of job regarding nervous loads) exerted the certain influence on the development of these neurologic syndromes. In the long-term period after an exposure the cerebrovascular diseases were most frequent. Their incidence was naturally related with the age of patients. However, it was determined that the initial clinical manifestations of a cerebral atherosclerosis in persons exposed to irradiation in doses more of 2.5 Gy/year were registered in younger age than in control group. The frequency of their development depended on an annual dose of a gamma-irradiation, age at the moment of an exposure, degree of manifestation and duration of preceding vegetative - vascular disorders. (author)

  12. Radiation exposure of U.S. military individuals.

    Science.gov (United States)

    Blake, Paul K; Komp, Gregory R

    2014-02-01

    The U.S. military consists of five armed services: the Army, Navy, Marine Corps, Air Force, and Coast Guard. It directly employs 1.4 million active duty military, 1.3 million National Guard and reserve military, and 700,000 civilian individuals. This paper describes the military guidance used to preserve and maintain the health of military personnel while they accomplish necessary and purposeful work in areas where they are exposed to radiation. It also discusses military exposure cohorts and associated radiogenic disease compensation programs administered by the U.S. Department of Veterans Affairs, the U.S. Department of Justice, and the U.S. Department of Labor. With a few exceptions, the U.S. military has effectively employed ionizing radiation since it was first introduced during the Spanish-American War in 1898. The U.S military annually monitors 70,000 individuals for occupational radiation exposure: ~2% of its workforce. In recent years, the Departments of the Navy (including the Marine Corps), the Army, and the Air Force all have a low collective dose that remains close to 1 person-Sv annually. Only a few Coast Guard individuals are now routinely monitored for radiation exposure. As with the nuclear industry as a whole, the Naval Reactors program has a higher collective dose than the remainder of the U.S. military. The U.S. military maintains occupational radiation exposure records on over two million individuals from 1945 through the present. These records are controlled in accordance with the Privacy Act of 1974 but are available to affected individuals or their designees and other groups performing sanctioned epidemiology studies.Introduction of Radiation Exposure of U.S. Military Individuals (Video 2:19, http://links.lww.com/HP/A30). PMID:24378502

  13. Radiation Exposure of Abdominal Cone Beam Computed Tomography

    International Nuclear Information System (INIS)

    PurposeTo evaluate patients radiation exposure of abdominal C-arm cone beam computed tomography (CBCT).MethodsThis prospective study was approved by the institutional review board; written, informed consent was waived. Radiation exposure of abdominal CBCT was evaluated in 40 patients who underwent CBCT during endovascular interventions. Dose area product (DAP) of CBCT was documented and effective dose (ED) was estimated based on organ doses using dedicated Monte Carlo simulation software with consideration of X-ray field location and patients’ individual body weight and height. Weight-dependent ED per DAP conversion factors were calculated. CBCT radiation dose was compared to radiation dose of procedural fluoroscopy. CBCT dose-related risk for cancer was assessed.ResultsMean ED of abdominal CBCT was 4.3 mSv (95 % confidence interval [CI] 3.9; 4.8 mSv, range 1.1–7.4 mSv). ED was significantly higher in the upper than in the lower abdomen (p = 0.003) and increased with patients’ weight (r = 0.55, slope = 0.045 mSv/kg, p < 0.001). Radiation exposure of CBCT corresponded to the radiation exposure of on average 7.2 fluoroscopy minutes (95 % CI 5.5; 8.8 min) in the same region of interest. Lifetime risk of exposure related cancer death was 0.033 % or less depending on age and weight.ConclusionsMean ED of abdominal CBCT was 4.3 mSv depending on X-ray field location and body weight

  14. Radiation Exposure of Abdominal Cone Beam Computed Tomography

    Energy Technology Data Exchange (ETDEWEB)

    Sailer, Anna M., E-mail: anni.sailer@mumc.nl [Maastricht University Medical Centre (MUMC), Department of Radiology (Netherlands); Schurink, Geert Willem H., E-mail: gwh.schurink@mumc.nl [Maastricht University Medical Centre, Department of Surgery (Netherlands); Wildberger, Joachim E., E-mail: j.wildberger@mumc.nl; Graaf, Rick de, E-mail: r.de.graaf@mumc.nl; Zwam, Willem H. van, E-mail: w.van.zwam@mumc.nl; Haan, Michiel W. de, E-mail: m.de.haan@mumc.nl; Kemerink, Gerrit J., E-mail: gerrit.kemerink@mumc.nl; Jeukens, Cécile R. L. P. N., E-mail: cecile.jeukens@mumc.nl [Maastricht University Medical Centre (MUMC), Department of Radiology (Netherlands)

    2015-02-15

    PurposeTo evaluate patients radiation exposure of abdominal C-arm cone beam computed tomography (CBCT).MethodsThis prospective study was approved by the institutional review board; written, informed consent was waived. Radiation exposure of abdominal CBCT was evaluated in 40 patients who underwent CBCT during endovascular interventions. Dose area product (DAP) of CBCT was documented and effective dose (ED) was estimated based on organ doses using dedicated Monte Carlo simulation software with consideration of X-ray field location and patients’ individual body weight and height. Weight-dependent ED per DAP conversion factors were calculated. CBCT radiation dose was compared to radiation dose of procedural fluoroscopy. CBCT dose-related risk for cancer was assessed.ResultsMean ED of abdominal CBCT was 4.3 mSv (95 % confidence interval [CI] 3.9; 4.8 mSv, range 1.1–7.4 mSv). ED was significantly higher in the upper than in the lower abdomen (p = 0.003) and increased with patients’ weight (r = 0.55, slope = 0.045 mSv/kg, p < 0.001). Radiation exposure of CBCT corresponded to the radiation exposure of on average 7.2 fluoroscopy minutes (95 % CI 5.5; 8.8 min) in the same region of interest. Lifetime risk of exposure related cancer death was 0.033 % or less depending on age and weight.ConclusionsMean ED of abdominal CBCT was 4.3 mSv depending on X-ray field location and body weight.

  15. Inflammatory and Remodeling Events in Asthma with Chronic Exposure to House Dust Mites: A Murine Model

    OpenAIRE

    Ahn, Joong Hyun; Kim, Chi Hong; Kim, Yong Hyun; Kim, Seung Joon; Lee, Sook-Young; Kim, Young Kyoon; Kim, Kwan Hyoung; Moon, Hwa Sik; Song, Jeong Sup; Park, Sung Hak; Kwon, Soon Seog

    2007-01-01

    Although animal models with ovalbumin have been used to study chronic asthma, there are difficulties in inducing recurrence as well as in maintaining chronic inflammation in this system. Using a murine model of house dust mite (HDM)-induced bronchial asthma, we examined the airway remodeling process in response to the chronic exposure to HDM. During the seventh and twelfth weeks of study, HDM were inhaled through the nose for three consecutive days and airway responsiveness was measured. Twen...

  16. Cellular and subcellular alterations in immune cells induced by chronic, intermittent exposure in vivo to very low doses of ionizing radiation (LDR), and its ameliorating effects on progression of autoimmune disease and mammary tumor growth

    International Nuclear Information System (INIS)

    Previous studies have shown that low doses of ionizing radiation can enhance immune response and down-regulate tumor incidence. This suggested that low dose ionizing radiation can act as a hormetic agent by modulating antigen-stimulated clonal growth and/or differentiation of immune cells. A mouse model was therefore developed to investigate the enhancing effect of LDR at the cellular and organismic levels. At he cellular level, the author investigated the up-regulating effect of LDR on the proliferative growth of mitogen-stimulated splenocytes and on the modulating influence of LDR on thymocytes undergoing differentiation. At the organismic level, the up-regulating effects of LDR on the resistance to spontaneously occurring mammary tumor and lupus-type autoimmune disease were investigated. (author). 14 refs., 2 tabs

  17. Influence of materials choice on occupational radiation exposure in ITER

    Science.gov (United States)

    Forty, C. B. A.; Firth, J. D.; Butterworth, G. J.

    1998-10-01

    In fission reactor plant,the radiation doses associated with inspection and maintenance of the primary cooling circuit account for a substantial fraction of the collective occupational radiation exposure (ORE). Similarly, it is anticipated that much of the ORE occurring during normal operation of ITER will arise from active deposits in the cooling loop. Using a number of calculation steps ranging from neutron activation analysis, mobilisation and transport modelling and Monte Carlo simulation, estimates for the gamma photon flux and radiation dose fields around a typical `hot-leg' cooling pipe have been made taking SS316,OPTSTAB, MANET-II and F-82H steels as alternative candidate loop materials.

  18. Long-term effects of radiation exposure on health.

    Science.gov (United States)

    Kamiya, Kenji; Ozasa, Kotaro; Akiba, Suminori; Niwa, Ohstura; Kodama, Kazunori; Takamura, Noboru; Zaharieva, Elena K; Kimura, Yuko; Wakeford, Richard

    2015-08-01

    Late-onset effects of exposure to ionising radiation on the human body have been identified by long-term, large-scale epidemiological studies. The cohort study of Japanese survivors of the atomic bombings of Hiroshima and Nagasaki (the Life Span Study) is thought to be the most reliable source of information about these health effects because of the size of the cohort, the exposure of a general population of both sexes and all ages, and the wide range of individually assessed doses. For this reason, the Life Span Study has become fundamental to risk assessment in the radiation protection system of the International Commission on Radiological Protection and other authorities. Radiation exposure increases the risk of cancer throughout life, so continued follow-up of survivors is essential. Overall, survivors have a clear radiation-related excess risk of cancer, and people exposed as children have a higher risk of radiation-induced cancer than those exposed at older ages. At high doses, and possibly at low doses, radiation might increase the risk of cardiovascular disease and some other non-cancer diseases. Hereditary effects in the children of atomic bomb survivors have not been detected. The dose-response relation for cancer at low doses is assumed, for purposes of radiological protection, to be linear without a threshold, but has not been shown definitively. This outstanding issue is not only a problem when dealing appropriately with potential health effects of nuclear accidents, such as at Fukushima and Chernobyl, but is of growing concern in occupational and medical exposure. Therefore, the appropriate dose-response relation for effects of low doses of radiation needs to be established. PMID:26251392

  19. Cancer risk estimation caused by radiation exposure during endovascular procedure

    Science.gov (United States)

    Kang, Y. H.; Cho, J. H.; Yun, W. S.; Park, K. H.; Kim, H. G.; Kwon, S. M.

    2014-05-01

    The objective of this study was to identify the radiation exposure dose of patients, as well as staff caused by fluoroscopy for C-arm-assisted vascular surgical operation and to estimate carcinogenic risk due to such exposure dose. The study was conducted in 71 patients (53 men and 18 women) who had undergone vascular surgical intervention at the division of vascular surgery in the University Hospital from November of 2011 to April of 2012. It had used a mobile C-arm device and calculated the radiation exposure dose of patient (dose-area product, DAP). Effective dose was measured by attaching optically stimulated luminescence on the radiation protectors of staff who participates in the surgery to measure the radiation exposure dose of staff during the vascular surgical operation. From the study results, DAP value of patients was 308.7 Gy cm2 in average, and the maximum value was 3085 Gy cm2. When converted to the effective dose, the resulted mean was 6.2 m Gy and the maximum effective dose was 61.7 milliSievert (mSv). The effective dose of staff was 3.85 mSv; while the radiation technician was 1.04 mSv, the nurse was 1.31 mSv. All cancer incidences of operator are corresponding to 2355 persons per 100,000 persons, which deemed 1 of 42 persons is likely to have all cancer incidences. In conclusion, the vascular surgeons should keep the radiation protection for patient, staff, and all participants in the intervention in mind as supervisor of fluoroscopy while trying to understand the effects by radiation by themselves to prevent invisible danger during the intervention and to minimize the harm.

  20. A novel antibody-based biomarker for chronic algal toxin exposure and sub-acute neurotoxicity

    Science.gov (United States)

    Lefebvre, Kathi A.; Frame, Elizabeth R.; Gulland, Frances; Hansen, John D.; Kendrick, Preston S.; Beyer, Richard P.; Bammler, Theo K.; Farin, Frederico M.; Hiolski, Emma M.; Smith, Donald R.; Marcinek, David J.

    2012-01-01

    The neurotoxic amino acid, domoic acid (DA), is naturally produced by marine phytoplankton and presents a significant threat to the health of marine mammals, seabirds and humans via transfer of the toxin through the foodweb. In humans, acute exposure causes a neurotoxic illness known as amnesic shellfish poisoning characterized by seizures, memory loss, coma and death. Regular monitoring for high DA levels in edible shellfish tissues has been effective in protecting human consumers from acute DA exposure. However, chronic low-level DA exposure remains a concern, particularly in coastal and tribal communities that subsistence harvest shellfish known to contain low levels of the toxin. Domoic acid exposure via consumption of planktivorous fish also has a profound health impact on California sea lions (Zalophus californianus) affecting hundreds of animals yearly. Due to increasing algal toxin exposure threats globally, there is a critical need for reliable diagnostic tests for assessing chronic DA exposure in humans and wildlife. Here we report the discovery of a novel DA-specific antibody response that is a signature of chronic low-level exposure identified initially in a zebrafish exposure model and confirmed in naturally exposed wild sea lions. Additionally, we found that chronic exposure in zebrafish caused increased neurologic sensitivity to DA, revealing that repetitive exposure to DA well below the threshold for acute behavioral toxicity has underlying neurotoxic consequences. The discovery that chronic exposure to low levels of a small, water-soluble single amino acid triggers a detectable antibody response is surprising and has profound implications for the development of diagnostic tests for exposure to other pervasive environmental toxins.

  1. Modelling of aircrew radiation exposure during solar particle events

    Science.gov (United States)

    Al Anid, Hani Khaled

    In 1990, the International Commission on Radiological Protection recognized the occupational exposure of aircrew to cosmic radiation. In Canada, a Commercial and Business Aviation Advisory Circular was issued by Transport Canada suggesting that action should be taken to manage such exposure. In anticipation of possible regulations on exposure of Canadian-based aircrew in the near future, an extensive study was carried out at the Royal Military College of Canada to measure the radiation exposure during commercial flights. The radiation exposure to aircrew is a result of a complex mixed-radiation field resulting from Galactic Cosmic Rays (GCRs) and Solar Energetic Particles (SEPs). Supernova explosions and active galactic nuclei are responsible for GCRs which consist of 90% protons, 9% alpha particles, and 1% heavy nuclei. While they have a fairly constant fluence rate, their interaction with the magnetic field of the Earth varies throughout the solar cycles, which has a period of approximately 11 years. SEPs are highly sporadic events that are associated with solar flares and coronal mass ejections. This type of exposure may be of concern to certain aircrew members, such as pregnant flight crew, for which the annual effective dose is limited to 1 mSv over the remainder of the pregnancy. The composition of SEPs is very similar to GCRs, in that they consist of mostly protons, some alpha particles and a few heavy nuclei, but with a softer energy spectrum. An additional factor when analysing SEPs is the effect of flare anisotropy. This refers to the way charged particles are transported through the Earth's magnetosphere in an anisotropic fashion. Solar flares that are fairly isotropic produce a uniform radiation exposure for areas that have similar geomagnetic shielding, while highly anisotropic events produce variable exposures at different locations on the Earth. Studies of neutron monitor count rates from detectors sharing similar geomagnetic shielding properties

  2. Analysis Radiation Exposure at Serpong Nuclear Research Center

    International Nuclear Information System (INIS)

    Nevertheless, along with its positive advantages, nuclear energy also potentially dangerous to the workers, public and environment, whose using the nuclear energy, whenever the requirements of safety radiation are not well establish. This study has purpose to know factors that related to the radiation dose received by the workers or their work environment since there were interaction among workers with his job and his work environment, in Serpong Nuclear Research Center. The design of the study was a cross sectional approach. The result of the study shown that 10% out of 100 radiation workers received radiation dose more than 15 mSv, and the result of the monitoring of work area environment, in general its obtained under 2.5 m R/hour. Therefore, it can still be classified as of controlled area. The result of the study using the statistical test shows that attitude, work procedures, supervision and radiation exposure of work area environment have a significant relationship with radiation dose. The most related of that factors were radiation exposure of work area, followed by the procedures having the Odds ratio value 90 and 14.95% Confidence Intervals respectively. (author)

  3. Radiation Exposure Alters Expression of Metabolic Enzyme Genes in Mice

    Science.gov (United States)

    Wotring, V. E.; Mangala, L. S.; Zhang, Y.; Wu, H.

    2011-01-01

    Most administered pharmaceuticals are metabolized by the liver. The health of the liver, especially the rate of its metabolic enzymes, determines the concentration of circulating drugs as well as the duration of their efficacy. Most pharmaceuticals are metabolized by the liver, and clinically-used medication doses are given with normal liver function in mind. A drug overdose can result in the case of a liver that is damaged and removing pharmaceuticals from the circulation at a rate slower than normal. Alternatively, if liver function is elevated and removing drugs from the system more quickly than usual, it would be as if too little drug had been given for effective treatment. Because of the importance of the liver in drug metabolism, we want to understand the effects of spaceflight on the enzymes of the liver and exposure to cosmic radiation is one aspect of spaceflight that can be modeled in ground experiments. Additionally, it has been previous noted that pre-exposure to small radiation doses seems to confer protection against later and larger radiation doses. This protective power of pre-exposure has been called a priming effect or radioadaptation. This study is an effort to examine the drug metabolizing effects of radioadaptation mechanisms that may be triggered by early exposure to low radiation doses.

  4. DOE Radiation Exposure Monitoring System (REMS) Data Update

    Energy Technology Data Exchange (ETDEWEB)

    Rao, Nimi; Hagemeyer, Derek

    2012-05-05

    This slide show presents the 2011 draft data for DOE occupational radiation exposure.Clarification is given on Reporting Data regarding: reporting Total Organ Dose (TOD); reporting Total Skin Dose (TSD), and Total Extremity Dose (TExD) ; and Special individuals reporting.

  5. Medical management of three workers following a radiation exposure incident

    Energy Technology Data Exchange (ETDEWEB)

    House, R.A.; Sax, S.E.; Rumack, E.R.; Holness, D.L. (Department of Occupational and Environmental Health, St. Michael' s Hospital, Toronto, Ontario (Canada))

    1992-01-01

    The medical management of three individuals involved in an exposure incident to whole-body radiation at a nuclear generating plant of a Canadian electrical utility is described. The exposure incident resulted in the two highest whole-body radiation doses ever received in a single event by workers in a Canadian nuclear power plant. The individual whole-body doses (127.4 mSv, 92.0 mSv, 22.4 mSv) were below the threshold for acute radiation sickness but the exposures still presented medical management problems related to assessment and counseling. Serial blood counting and lymphocyte cytogenetic analysis to corroborate the physical dosimetry were performed. All three employees experienced somatic symptoms due to stress and one employee developed post-traumatic stress disorder. This incident indicates that there is a need in such radiation exposure accidents for early and continued counseling of exposed employees to minimize the risk of development of stress-related symptoms.

  6. Medical management of three workers following a radiation exposure incident

    International Nuclear Information System (INIS)

    The medical management of three individuals involved in an exposure incident to whole-body radiation at a nuclear generating plant of a Canadian electrical utility is described. The exposure incident resulted in the two highest whole-body radiation doses ever received in a single event by workers in a Canadian nuclear power plant. The individual whole-body doses (127.4 mSv, 92.0 mSv, 22.4 mSv) were below the threshold for acute radiation sickness but the exposures still presented medical management problems related to assessment and counseling. Serial blood counting and lymphocyte cytogenetic analysis to corroborate the physical dosimetry were performed. All three employees experienced somatic symptoms due to stress and one employee developed post-traumatic stress disorder. This incident indicates that there is a need in such radiation exposure accidents for early and continued counseling of exposed employees to minimize the risk of development of stress-related symptoms

  7. Rights versus labour privileges for ionizing radiation exposure activities

    International Nuclear Information System (INIS)

    The present panorama of brazilian legislation concerning activities in which (may) occurs exposure to ionizing radiations, involves several incoherencies and privileges, as a consequence of legal rights generated from labor principles which have no social or scientific embasement. In this study, several legal labor topics are analysed and a new doutrinary context is proposed. (author)

  8. Radiation exposure of fertile women in medical research studies

    International Nuclear Information System (INIS)

    Fertile women may be exposed to ionizing radiation as human subjects in medical research studies. If the woman is pregnant, such exposures may result in risk to an embryo/fetus. Fertile women may be screened for pregnancy before exposure to ionizing radiation by interview, general examination, or pregnancy test. Use of the sensitive serum pregnancy test has become common because it offers concrete evidence that the woman is not pregnant (more specifically, that an embryo is not implanted). Evidence suggests that risk to the embryo from radiation exposure before organogenesis is extremely low or nonexistent. Further, demonstrated effects on organogenesis are rare or inconclusive at fetal doses below 50 mSv (5 rem). Therefore, there may be some level of radiation exposure below which risk to the fetus may be considered essentially zero, and a serum pregnancy test is unnecessary. This paper reviews the fetal risks and suggests that consideration be given to establishing a limit to the fetus of 0.5 mSv (50 mrem), below which pregnancy screening need not include the use of a serum pregnancy test

  9. Radiation exposure during fluoroscopy: Should we be protecting our thyroids?

    International Nuclear Information System (INIS)

    Recent reports on thyroid cancer among Australian orthopaedic surgeons prompted the present study which sought to evaluate the effectiveness of lead shielding in reducing radiation exposure (RE) to the thyroid region during endo-urological procedures. Radiation exposure to the thyroid region of the surgeon and scrubbed nurse was monitored for 20 consecutive operations over a 6-week period by thermoluminescent dosimeters (TLD). A TLD was placed over and underneath a thyroid shield of 0.5 mm lend equivalent thickness to monitor the effect of shielding. Eight percutaneous nephrolithotomies, seven retrograde pyelograms and ureteric stentings and five ureteroscopies for calculous disease were monitored. Total exposure time was 63.1 min. For the surgeon, the total cumulative RE over and under the lead shield was 0.46 and 0.02 mSv, respectively, equating to a 23-times reduction in RE if shielding was used. This effectively reduced RE to almost background levels, which was represented by the control TLD exposure (0.01 mSv). Although RE without thyroid shields did not exceed current standards set by radiation safety authorities, no threshold level has been set below which thyroid carcinogenesis is unlikely to occur. Because lead shields are easy to wear and can effectively reduce RE to the thyroid region to near-background levels, they should be made easily available and used by all surgeons to avoid the harmful effects of radiation on the thyroid

  10. Evaluation of illnesses associated with occupational exposure to ionizing radiation

    International Nuclear Information System (INIS)

    A retrospective study by the Institute of Occupational Medicine is presented of all cases of pathological indications of ionizing radiation exposure during the period 1990-1995. It describes the incidence of theses diseases and their relationship with other factors. It has shown the predominance of pathologies of the haemolymphopoietic system in individuals who work in radiological diagnostics

  11. UV Radiation Exposure of Composite Specimens, using the SPHERE

    OpenAIRE

    CORDELLE, Aurélie; LABORATOIRE CENTRAL DES PONTS ET CHAUSSEES - LCPC; NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY - NIST; ECOLE NATIONALE SUPERIEURE DE MECANIQUE ET D'AEROTECHNIQUE DE POITIERS - ENSMA

    2010-01-01

    The objectives of the research are to provide insight into the mechnical behavior of a unidirectional pultruded E-glass/vinylester composite, submitted to UV radiation exposure over several periods of time. The degradation of exposed samples will be carried out using the change of both local modulus and hardness.

  12. Metallic implants and exposure to radiofrequency radiation

    International Nuclear Information System (INIS)

    There is increasing use of radiofrequency radiation (RFR) in industry for communications, welding, security, radio, medicine, navigation etc. It has been recognised for some years that RFR may interact with cardiac pacemakers and steps have been taken to prevent this interference. It is less well recognised that other metallic implants may also act as antennas in an RFR field and possibly cause adverse health effects by heating local tissues. There are a large and increasing number of implants having metal components which may be found in RFR workers. These implants include artificial joints, rods and plates used in orthopaedics, rings in heart valves, wires in sutures, bionic ears, subcutaneous infusion systems and (external) transdermal drug delivery patches1. The physician concerned with job placement of such persons requires information on the likelihood of an implant interacting with RFR so as to impair health. The following outlines the approach developed in Telecom Australia, beginning with the general principles and then presenting a specific example discussion of a specific example

  13. Measurement of man's exposure to external radiation

    International Nuclear Information System (INIS)

    After outlining briefly the rationale for personnel radiation monitoring with integrating detectors, a review is presented of some developments which have taken place in personnel and environmental dosimetry during the past 3.5 years. The results of a pilot field experiment concerning the stability of film and thermoluminescent dosimeters (TLDs) in four Latin-American countries are summarized. It shows that film dosimeters should be used only with caution, and in locations with a moderate climate. A survey is being conducted on the current status and trends in personnel monitoring, involving detailed questioning of over 150 laboratories in about forty countries to obtain information on the type of service and detectors, evaluation and recordkeeping, additional applications, problem and development areas, intercomparisons, practical experiences with different systems, administrative and legal aspects, etc. According to the preliminary results, the trend is away from photographic film and towards mostly automatic TLD systems, not only in the industrialized countries but also in several of the larger and more advanced developing countries. The need for higher quality standards and frequent performance tests under realistic conditions is emphasized. Differences in the requirements for personnel and

  14. Information by the German Federal Government. Environmental radioactivity and radiation exposure in 2010

    International Nuclear Information System (INIS)

    The information by the German Federal Government on the environmental radioactivity and radiation exposure in 2010 includes five chapters. (I) Natural radiation exposure: radiation sources, contributions from cosmic radiation, contaminated construction materials, food and drinking water, and radon, evaluation of the different components of natural radiation exposure. (II) Civilization caused radiation exposure: nuclear power plants, research centers, nuclear fuel processing plants, other nuclear facilities (interim storage facilities, repositories); summarizing evaluation for nuclear facilities; environmental radioactivity due to mining; radioactive materials in research, technology and households; industrial and mining residues; fall-out as a consequence of the Chernobyl reactor accident and nuclear weapon testing. (III) Occupational radiation exposure: civil radiation sources, natural radiation sources, special events. (IV) Medical radiation exposure; X-ray diagnostics; nuclear medicine; radiotherapy using ionizing radiation; radiotherapy using open radioactive materials; evaluation of radiotherapy. (V) Non-ionizing radiation: electromagnetic fields; optical radiation; certification of solaria.

  15. Explanation of nurse standard of external exposure acute radiation sickness

    International Nuclear Information System (INIS)

    National occupational health standard-Nurse Standard of External Exposure Acute Radiation Sickness has been approved and issued by the Ministry of Health. Based on the extensive research of literature, collection of the previous nuclear and radiation accidents excessive exposed personnel data and specific situations in China, this standard was enacted according to the current national laws, regulations, and the opinions of peer experts. It is mainly used for care of patients with acute radiation sickness, and also has directive significance for care of patients with iatrogenic acute radiation sickness which due to the hematopoietic stem cell transplantation pretreatment. To correctly carry out this standard and to reasonably implement nursing measures for patients with acute radiation sickness, the contents of this standard were interpreted in this article. (authors)

  16. Explanation of diagnosis criteria for radiation sickness from internal exposure

    International Nuclear Information System (INIS)

    A revised edition of the Diagnostic Criteria for Radiation Sickness from Internal Exposure has been approved and issued by the Ministry of Health. It is necessary to research the internal radiation sickness to adapt to the current serious anti-terrorism situation. This standard was enacted based on the extensive research of related literature, from which 12 cases with internal radiation sickness and screened out were involving 7 types of radionuclide. The Development of Emergency Response Standard Extension Framework: Midterm Evaluation Report is the main reference which approved by the International Atomic Energy Agency and World Health Organization. This amendment contains many new provisions such as internal radiation sickness effects models and threshold dose, and the appendix added threshold dose of serious deterministic effects induced by radionuclide intake and radiotoxicology parameters of some radionuclides. In order to understand and implement this standard, and to diagnose and treat the internal radiation sickness correctly, the contents of this standard were interpreted in this article. (authors)

  17. Diagnostic and therapeutic approaches after suspected or confirmed extraordinary exposure to ionizing radiation of members of the German Armed Forces

    International Nuclear Information System (INIS)

    This report refers to the results of 5 working packages. The first of them deals in detail with 11 extraordinary radiation accidents resulting in a chronic or protracted/intermittent radiation exposure. In most of the cases, the radiation etiology of observed health impairments was suspected many days, weeks or months after the beginning of accidental exposure. Therefore, in the second package, a review of results of systematic chronic radiation exposures in dogs, rats and mice was done to try to understand the pathophysiology of observations in man. The key problem lies in the day-by-day radiation effects on hemopoietic stem cells and their capability to cope with the radiation induced excess cell loss. On this basis, diagnostic approaches to assess the functional potentials of cell renewal are outlined in package 3. These considerations lead to therapeutic recommendations (package 4): in case of an irreversible damage to the stem cell pool, a stem cell transplantation may be the only way to induce recovery. In case of a reversible damage, the transient hemopoietic failure can be bridged by appropriate supportive measures to prevent infection or bleeding. The package 5 recommends to initiation of continuing medical education for the Armed Forces Medical Services to deal with this type of extraordinary radiation accidents which may occur in any 'out-of-area' - mission. (orig.)

  18. Study of sensing technique of radiation exposure for sea foods

    International Nuclear Information System (INIS)

    Vitamin E in fish oil was increased by radiation exposure about 3kGy. But TMAO of fish was stable by about 10 kGy. Accordingly TMAO could not be used for a sensing technique. By radiation exposure, ortho-tyrosine and meta-tyrosine in muscle of prawn increased. From the experimental results of DSC and changes of various ATPase activities, it was clear that myosin and actin in fibril were not changed by direct exposure of muscle, although only interaction between myosin and actin increased. To use this phenomena for the sensing technique, MG-ATPase and EDTA-ATPase activity in muscle fibril need to be investigated. (S.Y.)

  19. Radiation exposure to the surgeon during closed interlocking intramedullary nailing

    Energy Technology Data Exchange (ETDEWEB)

    Levin, P.E.; Schoen, R.W. Jr.; Browner, B.D.

    1987-06-01

    During interlocking intramedullary nailing of twenty-five femoral and five tibial fractures, the primary surgeon wore both a universal film badge on the collar of the lead apron and a thermoluminescent dosimeter ring on the dominant hand to quantify the radiation that he or she received. When distal interlocking was performed, the first ring was removed and a second ring was used so that a separate recording could be made for this portion of the procedure. At the conclusion of the study, all of the recorded doses of radiation were averaged. The average amount of radiation to the head and neck during the entire procedure was 7.0 millirems of deep exposure and 8.0 millirems of shallow exposure. The average dose of radiation to the dominant hand during insertion of the intramedullary nail and the proximal interlocking screw was 13.0 millirems, while the average amount during insertion of the distal interlocking nail was 12.0 millirems. Both of these averages are well within the government guidelines for allowable exposure to radiation during one-quarter (three months) of a year. Precautions that are to be observed during this procedure are recommended.

  20. Radiation exposure in X-ray mammography - a review

    International Nuclear Information System (INIS)

    When discussing the radiation risk of X-ray mammography, the magnitude of the dose applied has decisive importance. The radiation exposure of the breast is the predominant factor in risk considerations, since it contributes more than 98% to the effective dose of this examination. At present, it is generally assumed that, with regard to cancer induction by ionizing radiation, the glandular tissue is the most vulnerable part in the breast. Therefore, the average glandular dose, i.e., the mean value of the absorbed dose in the glandular tissue, is used for a description of the radiation risk. The average glandular dose cannot be measured directly, but is calculated under certain assumptions from the experimentally determined entrance surface air kerma or entrance surface dose by the use of a so-called conversion factors. During the seventies, i.e., in the era of the industrial type X-ray film, the mean value of the average glandular dose per exposure for a larger sample of patients (n> 100) was about 20 mGy. Due to the progress in radiographic technique such as, for example, the use of sensitive filmscreen systems, optimized radiation qualities and modern automatic exposure control units this value has now decreased to about 1 mGy. Further dose reductions seem possible by the introduction of digital image receptors. (orig.)

  1. The ESOREX-Project - European studies of occupational radiation exposure

    International Nuclear Information System (INIS)

    National monitoring of occupational radiation exposure in Europe faces several new challenges. Occupational radiation protection was considerably intensified as well as extended by the adoption of the new basic safety standards in the Council Directive 96/29 EURATOM. This resulted in a substantial reduction of the annual dose limit. Furthermore, natural radiation exposure at the work place is now considered as occupational radiation exposure and thus has to be regulated. The Council Directive is not only an obligation for the current EU-Member States but also for the assessed and future Member States. Therefore, all concerned European states have to take actions in order to implement the Council Directive into adequate national regulations. The expanding Common European Market with its open borders leads to an increasing exchange of labour-force between Member States. The new dose limits must also be kept for migrating labour-force and outside workers. Therefore the updating of the individual dose history must likewise be guaranteed for transnational migrating outside-workers. These challenges meet with different national practices of occupational radiation monitoring. The European Commission has both to support the process of adaptation and to evaluate the effectiveness of the new Council Directive. It is the purpose of the ESOREX projects to provide information and international transparency for these tasks. (orig.)

  2. [The late sequelae of radiation exposure on the nervous system].

    Science.gov (United States)

    Kholodova, N B; Kuznetsova, G D; Zubovskiĭ, G A; Kazakova, P B; Buklina, S B

    1996-01-01

    Clinical, neuropsychologic, neurophysiologic as well as neuromorphologic (in legal cases) examinations of Chernobyl liquidators were performed. In addition, the study was made of the monkeys exposed to 1,5 Gy radiation. The results obtained testified to the organic character of cerebral damages. They may be characterised as chronic progressive discirculatory-hypoxic syndrome in which disorders of vascular permeability were expressed and dystrophic destructive irreversible alterations of nervous cells occurred. PMID:9012250

  3. Estimation of genetic risks of exposure to ionizing radiation: status in the year 2000

    International Nuclear Information System (INIS)

    Review of the advances in the estimation of genetic risks of exposure of human populations to ionizing radiation with particular emphasis on the advances of last decade is given. Among the latter are: upward revision of the estimates of the baseline frequencies of Mendelian diseases (from 1.25 to 2.4%); conceptual change in the use of a doubling dose based on human data on spontaneous mutation rates and mouse data on induced mutation rates; development of the concept of mutation component and its application to predict the reactivity of Mendelian and chronic multifactor diseases to induced mutations; concept that the major adverse effects of radiation exposure of human germ cells are likely to be manifest as multi-system developmental abnormalities and concept of potential recoverability correction factor to bridge the gap between induced mutations studied in mice and the risk of genetic disease in humans. For a population exposed to low LET, chronic low dose-rate irradiation the total risk per Gy is of order of ∼ 3.000 to 4.700 cases which represents ∼ 0.4 to 0.6% of the baseline frequency of these diseases. Main message is that at low doses of radiation of interest in risk estimation, the risk of adverse hereditary effects is low

  4. Effects of long-term chronic exposure to radionuclides in plant populations

    International Nuclear Information System (INIS)

    The results of field studies carried out on different plant species (winter rye and wheat, spring barley, oats, Scots pine, wild vetch, crested hairgrass) in various radioecological situations (nuclear weapon testing, the Chernobyl accident, uranium and radium processing) to investigate the effects of long-term chronic exposure to radionuclides are discussed. Plant populations growing in areas with relatively low levels of pollution are characterized by an increased level of both cytogenetic disturbances and genetic diversity. Although ionizing radiation causes primary damage at the molecular level, there are emergent effects at the level of populations, non-predictable from the knowledge of elementary mechanisms of cellular effects formation. Accumulation of cellular alterations may afterward influence biological parameters important for populations such as health and reproduction. Presented data provide evidence that in plant populations inhabiting heavily contaminated territories cytogenetic damage could be accompanied by a decrease in reproductive capacity. However, in less contaminated sites, because of the scarcity of data available, a steady relationship between cytogenetic effects and reproductive capacity was not revealed. Under radioactive contamination of the plant's environment, a population's resistance to exposure may increase. However, there are radioecological situations where an enhanced radioresistance has not evolved or has not persisted

  5. Effects upon health of occupational exposure to microwave radiation (radar)

    International Nuclear Information System (INIS)

    The effects of occupational experience with microwave radiation (radar) on the health of US enlisted Naval personnel were studied in cohorts of approximately 20,000 men with maximum opportunity for exposure (electronic equipment repair) and 20,000 with minimum potential for exposure (equipment operation) who served during the Korean War period. Potential exposure was assessed in terms of occupational duties, length of time in occupation and power of equipment at the time of exposure. Actual exposure to members of each cohort could not be established. Mortality by cause of death, hospitalization during military service, later hospitalization in Veterans Administration (VA) facilities, and VA disability compensation were the health indexes studied, largely through the use of automated record systems. No adverse effects were detected in these indexes that could be attributed to potential microwave radiation exposures during the period 1950-1954. Functional and behavioral changes and ill-defined conditions, such as have been reported as microwave effects, could not be investigated in this study but subgroups of the living study population can be identified for expanded follow-up

  6. Efficacy of a radiation safety education initiative in reducing radiation exposure in the pediatric IR suite

    International Nuclear Information System (INIS)

    The use of ionizing radiation is essential for diagnostic and therapeutic imaging in the interventional radiology (IR) suite. As the complexity of procedures increases, radiation exposure risk increases. We believed that reinforcing staff education and awareness would help optimize radiation safety. To evaluate the effect of a radiation safety education initiative on IR staff radiation safety practices and patient radiation exposure. After each fluoroscopic procedure performed in the IR suite during a 4-month period, dose-area product (DAP), fluoroscopy time, and use of shielding equipment (leaded eyeglasses and hanging lead shield) by IR physicians were recorded. A lecture and article were then given to IR physicians and technologists that reviewed ALARA principles for optimizing radiation dose. During the following 4 months, those same parameters were recorded after each procedure. Before education 432 procedures were performed and after education 616 procedures were performed. Physician use of leaded eyeglasses and hanging shield increased significantly after education. DAP and fluoroscopy time decreased significantly for uncomplicated peripherally inserted central catheters (PICC) procedures and non-PICC procedures after education, but did not change for complicated PICC procedures. Staff radiation safety education can improve IR radiation safety practices and thus decrease exposure to radiation of both staff and patients. (orig.)

  7. Micronucleus assay in human lymphocytes as a bio dosimeter of in vivo acute and chronic exposures

    International Nuclear Information System (INIS)

    To assess the persistence over time of micronuclei (MN) in lymphocytes of cancer patients after radiotherapy and, consequently, to verify the suitability of MN test as a dosimeter for monitoring in vivo ionizing radiation damage, the cytokinesis-blocked MN assay was applied in peripheral blood lymphocytes of cervix and head and neck cancer patients (n = 34). The evaluation of data suggests that: 1) MN frequency increases linearly with the equivalent total-body absorbed dose (R2 = 0,9; P=0,015); 2) The distribution of the MN yields deviates significantly from Poisson with the increase of equivalent total-body dose (σ2/y = 1,14 mean value); 3) The comparison of spontaneous MN frequencies in healthy subjects with those in cancer patients, prior to radiotherapy, shows significant differences (p<0,01); and 4) It is observed a general decline in MN frequencies with time after radiotherapy, with considerable variations between patients. The kinetics of elimination of MN seems to follow a two-term exponential function, with a short and a long term. Patients with the highest equivalent total-body dose (total tumoral dose: 60-80 Gy) initially tend to have the fastest decline. At 6-18 months of follow-up time 11 of the 17 patients, evaluated 2-480 months post-treatment, showed higher frequencies of MN than their respective levels before radiation therapy, indicating persistence of radiation induced cytogenetic damage. Further studies modeling changes in chromosome aberrations with acute and chronic exposures should provide perspectives on biological dosimetry in accident situations in which there is a blood sampling delay and on biological monitoring of human populations exposed to ionizing radiation. (author)

  8. Evidence Report: Risk of Cardiovascular Disease and Other Degenerative Tissue Effects from Radiation Exposure

    Science.gov (United States)

    Patel, Zarana; Huff, Janice; Saha, Janapriya; Wang, Minli; Blattnig, Steve; Wu, Honglu; Cucinotta, Francis

    2015-01-01

    Occupational radiation exposure from the space environment may result in non-cancer or non-CNS degenerative tissue diseases, such as cardiovascular disease, cataracts, and respiratory or digestive diseases. However, the magnitude of influence and mechanisms of action of radiation leading to these diseases are not well characterized. Radiation and synergistic effects of radiation cause DNA damage, persistent oxidative stress, chronic inflammation, and accelerated tissue aging and degeneration, which may lead to acute or chronic disease of susceptible organ tissues. In particular, cardiovascular pathologies such as atherosclerosis are of major concern following gamma-ray exposure. This provides evidence for possible degenerative tissue effects following exposures to ionizing radiation in the form of the GCR or SPEs expected during long-duration spaceflight. However, the existence of low dose thresholds and dose-rate and radiation quality effects, as well as mechanisms and major risk pathways, are not well-characterized. Degenerative disease risks are difficult to assess because multiple factors, including radiation, are believed to play a role in the etiology of the diseases. As additional evidence is pointing to lower, space-relevant thresholds for these degenerative effects, particularly for cardiovascular disease, additional research with cell and animal studies is required to quantify the magnitude of this risk, understand mechanisms, and determine if additional protection strategies are required.The NASA PEL (Permissive Exposure Limit)s for cataract and cardiovascular risks are based on existing human epidemiology data. Although animal and clinical astronaut data show a significant increase in cataracts following exposure and a reassessment of atomic bomb (A-bomb) data suggests an increase in cardiovascular disease from radiation exposure, additional research is required to fully understand and quantify these adverse outcomes at lower doses (less than 0.5 gray

  9. Experimental long-term exposures of fish to low dose rate gamma- or alpha-radiation

    International Nuclear Information System (INIS)

    While it is well known that α-radiation is much more damaging than γ-radiation (on an equal absorbed dose basis) to man and mammals, there are no data available to compare the effects of these radiations on fish. As many authorised disposals of radioactivity are made to sea or rivers and include α- and γ-emitters it is important that such data is obtained so that estimates of the combined biological damaging effects may be made. This paper describes experiments made to examine the comparative effects of chronic exposure to α- or γ-radiation on reproductive endpoints in a representative fish, the zebrafish Danio rerio. Fish were exposed to γ-radiation or α-radiation for approximately 1 year. The fish were allowed to breed once per week and for each breeding opportunity the total numbers of eggs, numbers of eggs viable at 24 hours and eggs hatching successfully were recorded. Dose rate groups were 300, 1000 or 7400μGy h-1 for γ-radiation and 9.6, 19, 84 and 214μGy h-1 for α-radiation. None of the α-radiation groups showed significant effects on any measure of egg production while among γ-radiation groups only the highest, 7400μGy h-1 group showed an effect. This was a rapid decrease in total number of eggs and viable eggs laid per opportunity, leading to a failure to lay any after 20 weekly opportunities. There was, however, no significant decrease in any group in the hatch rate of eggs which were viable at 24 hours. Comparison of the highest α-radiation dose rate which produced no effect (214μGy h-1) and the γ-radiation dose rate which had a significant effect (7400μGy h-1) gives a relative biological effect (RBEα) of <35. (author)

  10. Evaluation on Reproducibility of Space Radiation Generator and on Biodosimetry of Exposure to Space Radiation

    International Nuclear Information System (INIS)

    This report has been reviewed in draft form by individuals chosen for their diverse perspectives and technical expertise, in accordance with references. And second part is establishment of biodosimetry for space radiation exposure using cellular transformation activity and micronuclei production. These data may give the direction to future research fields in space radiation biology

  11. Epidemiological studies on radiation carcinogenesis in human populations following acute exposure: nuclear explosions and medical radiation

    International Nuclear Information System (INIS)

    The current knowledge of the carcinogenic effect of radiation in man is considered. The discussion is restricted to dose-incidence data in humans, particularly to certain of those epidemiological studies of human populations that are used most frequently for risk estimation for low-dose radiation carcinogenesis in man. Emphasis is placed solely on those surveys concerned with nuclear explosions and medical exposures

  12. Understanding of radiation protection in medicine. Pt. 1. Knowledge about radiation exposure and anxiety about radiation injury

    International Nuclear Information System (INIS)

    Using a questionnaire we investigated whether radiation exposure in correctly understood by medical doctors (n=140), nurses (n=496) and the general public (n=236). Thirty-three percent of medical doctors, 53% of nurses and the general public did not know who is legally allowed to irradiate the human body. Forty-five percent of doctors, 63% of nurses and 48% of the general public complained of anxiety about radiation injury. Fifty-six percent of patients did not ask medical doctors or nurses for an explanation of the risk of exposure. Moreover, 64% of doctors did not explain the risk to patients. In addition, 21% of doctors, 46% of nurses and the general public incorrectly understood that x-rays remain in the examination room. Twenty-seven percent of doctors, 49% of nurses and 80% of the general public did not know the ten-day rule. In conclusion, the results of this questionnaire indicated that basic knowledge about radiation exposure was not adequate. To protect against medical radiation exposure, personnel who are licensed to irradiate to the human body should be well recognized by medical staff and the general public. It is also important that informed consent for radiological examinations be based on fundamental knowledge about radiation exposure. Therefore, to reach a general consensus on radiological examinations and to reduce individual exposure, general public education regarding radiation protection is required. Postgraduate education on radiation protection for medical doctors and nurses is also strongly recommended. (author)

  13. β-radiation exposure with 188Re-labelled pharmaceuticals

    International Nuclear Information System (INIS)

    Aim: The number of therapies with radiopharmaceuticals labelled with 188Re is increasing requiring the documentation of the beta radiation exposure Hp(0.07) of the staff at all working and production sites and during the application and follow-up of the patient according to the new German Radiation Protection Law (StrlSchV). However, data for β-radiation exposure are rare. Therefore, we determined the personal dose Hp(0.07) of the skin of the hands handling 188Re radiopharmaceuticals to identify steps of high radiation exposure and to optimize working conditions. Method: Thermoluminescence dosimeters (TLD 100) were fixed to the fingertips of the radiochemist, the physician and the nurse and compared to official ring dosimeters. In addition, to monitor radiation exposure continuously readable electronic beta- and gamma dosimeters EPD (Siemens) were used. At eight days in which therapies were performed these readings were evaluated. Results: Considering one therapy with a 188Re-labelled radiopharmaceutical the middle finger of the radiochemist (production) and the physician (application) showed a radiation burden of 894 and 664 μSv/GBq, respectively. The cumulative dose of the fingertips after eight days of therapy was 249 and 110 mSv for the radiochemist and physician, respectively. A cumulative finger dose after eight days of therapy of 17 and 39 μSv/GBq was found for physician and nurse leading to a Hp(0.07) of 3 and 6 mSv, respectively. Preparing the radiopharmaceutical labelled with 20 GBq of 188Re the reading of the personal electronic dosimeter of the radiochemist showed a γ-dose rate Hp(10) of 55 μSv/h and a β-dose rate Hp(0.07) of 663 μSv/h which are obviously not representative for the true radiation dose to the skin of the fingertips. Conclusion: During therapy with 188Re-labelled radiopharmaceuticals the true radiation dose to the skin of the finger tips exceeds by far the readings of the official ring dosimeters as well as the continuously

  14. Personnel Monitoring of External Exposures Resulting from Radiation Accidents

    International Nuclear Information System (INIS)

    Part I. A brief review of methods and techniques for estimating the doses received from external sources in radiation accidents with emphasis on research and the development of improved methods is presented. Dosimetry methods such as film badges, ionization chambers, radio photoluminescence, radio thermoluminescence, conductivity, electronexoemission, track and activation detectors and individual alarm systems are discussed. Comparisons are made between their operational characteristics and the overall impression is broadly summarized. Part II. The mechanical model for expressing rems in connection with the present-day practice of personnel monitoring of external exposures is discussed. The necessary precision of dosimeters, the estimation of the exposure dose from dosimeter readings, the estimation of absorbed dose from exposure dose and, finally, dose-equivalent transformations are analysed. All necessary aspects of such transformations are mentioned. The role of the time estimation of the dose received and recovery during protracted accidental exposures are discussed. (author)

  15. Radiation Exposure Reduction to Brachytherapy Staff By Using Remote Afterloading

    International Nuclear Information System (INIS)

    The radiation exposures to the personnel staff from patients with brachytherapy implants in a brachytherapy service were reviewed. Exposures to the brachytherapy personnel, as determined by Thermoluminescence Dosimeter (TLD) monitors, indicates a four-fold reduction in exposures after the implantation of the use of remote afterloading devices. Quarterly TLD monitor data for seven quarters prior to the use of remote afterloading devices demonstrate an average projected annual dose equivalent to the brachytherapy staff of 2543 Μ Sv. After the implantation of the remote afterloading devices, the quarterly TLD monitor data indicate an average dose equivalent per person of 153 Μ Sv. This is 76% reduction in exposure to brachytherapy personnel with the use of these devices

  16. Protective effects of quercetine on the neuronal injury in frontal cortex after chronic toluene exposure.

    Science.gov (United States)

    Kanter, Mehmet

    2013-08-01

    The aim of this study was designed to evaluate the possible protective effects of quercetine (QE) on the neuronal injury in the frontal cortex after chronic toluene exposure in rats. The rats were randomly allotted into one of the three experimental groups, namely, groups A (control), B (toluene treated) and C (toluene-treated with QE), where each group contains 10 animals. Control group received 1 ml of normal saline solution, and toluene treatment was performed by the inhalation of 3000 ppm toluene in an 8-h/day and 6-day/week order for 12 weeks. The rats in QE-treated group was given QE (15 mg/kg body weight) once a day intraperitoneally for 12 weeks, starting just after toluene exposure. Tissue samples were obtained for histopathological investigation. To date, no histopathological changes of neurodegeneration in the frontal cortex after chronic toluene exposure in rats by QE treatment have been reported. In this study, the morphology of neurons in the QE treatment group was well protected. Chronic toluene exposure caused severe degenerative changes, shrunken cytoplasm and extensively dark picnotic nuclei in neurons of the frontal cortex. We conclude that QE therapy causes morphologic improvement in neurodegeneration of frontal cortex after chronic toluene exposure in rats. We believe that further preclinical research into the utility of QE may indicate its usefulness as a potential treatment on neurodegeneration after chronic toluene exposure in rats. PMID:22252859

  17. Occupational radiation protection: Protecting workers against exposure to ionizing radiation. Proceedings of an international conference

    International Nuclear Information System (INIS)

    Occupational exposure to ionizing radiation can occur in a range of industries, in mining and milling, in medical institutions, in educational and research establishments and in nuclear fuel cycle facilities. The term 'occupational exposure' refers to the radiation exposure incurred by a worker which is attributable to the worker's occupation and received or committed during a period of work. According to the latest (2000) Report of the United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR), an estimated 11 million workers worldwide are monitored for exposure to ionizing radiation. They incur radiation doses which range from a small fraction of the global average background exposure to natural radiation up to several times that value. The International Basic Safety Standards for Protection against Ionizing Radiation and for the Safety of Radiation Sources (BSS), which are co-sponsored by, amongst others, the IAEA, the International Labour Organization (ILO), the OECD Nuclear Energy Agency (OECD/NEA) and the World Health Organization (WHO), establish a system of radiation protection of which the provisions for occupational exposure are a substantial component. Guidance supporting the requirements of the BSS for occupational protection is provided in three Safety Guides, jointly sponsored by the IAEA and the ILO, and describing, for example, the implications for employers in discharging their main responsibilities (such as setting up appropriate radiation protection programmes) and similarly for workers (such as properly using the radiation monitoring devices provided to them). It should be noted, however, that radiation protection is only one factor that must be addressed in order to protect the worker's overall health and safety. The occupational radiation protection programme should be established and managed in co-ordination with other health and safety disciplines. Less than half of the occupationally exposed workers are exposed to

  18. Oral Methylphenidate Alleviates the Fine Motor Dysfunction Caused by Chronic Postnatal Manganese Exposure in Adult Rats

    OpenAIRE

    Beaudin, Stéphane A.; Strupp, Barbara J.; Lasley, Stephen M.; Fornal, Casimir A.; Mandal, Shyamali; Smith, Donald R

    2015-01-01

    Developmental manganese (Mn) exposure is associated with motor dysfunction in children and animal models, but little is known about the underlying neurochemical mechanisms or the potential for amelioration by pharmacotherapy. We investigated whether methylphenidate (MPH) alleviates fine motor dysfunction due to chronic postnatal Mn exposure, and whether Mn exposure impairs brain extracellular dopamine (DA) and norepinephrine (NE) in the prefrontal cortex (PFC) and striatum in adult animals. R...

  19. The health status of grandchildren of subjects occupationally exposed to chronic radiation. Communication 2. Morphofunctional parameters

    International Nuclear Information System (INIS)

    The study was aimed at investigation of the parameters of physical development and specific features in the development of psychomotor habits and peripheral blood parameters in children aged 0 to 7 grandchildren of exposed individuals. A dynamic follow-up of physical and psychomotor development, as well as regular check-ups of peripheral blood were carried out in 877 grandchildren of test subjects occupationally exposed to chronic radiation before conception. Multifactorial analysis did not show a correlation between the deviations in the physical development of children in the studied cohort and exposure of their grandparents and/or parents. Factors other than radiation (poor health status of mother, gestosis) did influence the studied parameters. The mean levels of hemoglobin, red cells, platelets, and leukocytes in the test group were virtually the same as in controls and coincided with published data

  20. Antioxidant system correction in the persons with chronic gastroduodenitis exposed to radiation

    International Nuclear Information System (INIS)

    The authors report the results of investigation of lipids peroxide oxidation (LPO) and antioxidant system of leukocytes and blood serum in 103 patients with chronic gastroduodenitis. In 56 patients, the disease was diagnosed after exposure to radiation during 48 ± 4.5 days (total dose -19 ± 2.3 cGy). The control group included 48 patients with the same disease of similar age and sex which were not exposed to ionizing radiation. Unithiolum and vitamin E in generally accepted doses were used to control the state of the antioxidant system. Administration of the preparations produced a positive clinical effect which was confirmed by the data of biochemical studies (activization of antioxidant system under the background of LPO inhibition

  1. Occupational radiation exposure in the Florida phosphate industry

    International Nuclear Information System (INIS)

    Uranium and its decay series are associated with phosphate deposits; consequently, phosphate mining and chemical processing present the potential for exposure to 'technologically enhanced natural radiation'. Exposure to Florida phosphate workers was studied by determining the radium content of various materials in mining and processing and measuring gamma radiation, airborne short-lived radon progeny and airborne long-lived alpha radioactivity. Radiation exposures were generally within occupational limits and levels were sufficiently low to qualify most areas as non-restricted areas. However, several areas and operations were identified as potentially requiring restricted area procedures. Radium is concentrated in sediment and scale in phosphoric acid production tanks, filters, and piping, and it was recommended that special close-contact operations such as cleaning and maintenance in these areas be individually evaluated to determine the need for further survey and personnel monitoring. While airborne radon progeny concentrations were below permissible levels in well-ventilated rock-loading tunnels, high occupancy of poorly ventilated tunnels presents the opportunity for cumulative exposures on the order of occupational limits. Improved ventilation and continued surveillance were recommended for these tunnels and any other occupied spaces of limited ventilation containing significant inventories of phosphate rock or products. Airborne long-lived alpha radioactivity concentrations in selected dry rock and fertilizer handling operations prompted a recommendation of further surveillance and possible reduction of dustiness, decrease of occupancy and/or provision of respiratory protection. This work was performed under a contract from the Florida Phosphate Council. (author)

  2. Metaphase chromosome aberrations as markers of radiation exposure and dose

    International Nuclear Information System (INIS)

    Chromosome aberration frequency provides the most reliable biological marker of dose for detecting acute accidental radiation exposure. Significant radiation-induced changes in the frequency of chromosome aberrations can be detected at very low doses. Our paper provides information on using molecular chromosome probes ''paints'' to score chromosome damage and illustrates how technical advances make it possible to understand mechanisms involved during formation of chromosome aberrations. In animal studies chromosome aberrations provide a method to relate cellular damage to cellular dose. Using an In vivo/In vitro approach aberrations provided a biological marker of dose from radon progeny exposure which was used to convert WLM to dose in rat tracheal epithelial cells. Injection of Chinese hamsters with 144Ce which produced a low dose rate exposure of bone marrow to either low-LET radiation increased the sensitivity of the cells to subsequent external exposure to 60Co. These studies demonstrated the usefulness of chromosome damage as a biological marker of dose and cellular responsiveness

  3. Radiation exposure to anesthesiologist and nurse in the orthopedic room

    International Nuclear Information System (INIS)

    We report the radiation exposure dose received by the anesthesiologist and nurse in the orthopaedic operating room, when a fluoroscopic image intensifier is in use. This study was done in 12 femoral neck fracture operations performed from January to May 1995. Radiation was monitored with the MYDOSE MINIX PDM 107 made by Aloka Co. which were attached in front and behind the nurse's lead apron, in front of the lead apron of the anesthesiologist. The average imaging time was 9.78 min. The average radiation dose in front of the anesthesiologist is lead apron was 2.08μSV, and in front and behind the nurse's lead apron were 5.67μSV, 0.08μSV respectively. This study and review of the literature indicate that the operating room anesthesiologist and nurse receive a lower exposure than the orthopaedist. We can disregard the problem of radiation exposure to the anesthesiologist and nurse during an orthopaedic operation when they wear lead aprons and stand far from the patient. (author)

  4. Occupational radiation exposure of Kolar mining workers in Karnataka State

    International Nuclear Information System (INIS)

    Radon and its short lived decay products in dwellings and in atmosphere represent the main source of public exposure from the natural radiation. Radon, thoron and their progeny present in air contribute to nearly 50% of the average effective dose received by human beings from the natural radiation environment. Radon is a radioactive noble gas produced by the decay of uranium and thorium bearing minerals in rocks, soils and building materials having half life 3.82 days. UNSCEAR reported recently indicates that there is a remarkable coherence between the risk estimates developed from epidemiological studies from miners and residential case-control radon studies. The study area is around BGML at K.G.F. The study on the natural background radiation levels from the natural sources is important to evaluate the distribution of terrestrial radionuclides and radiation doses received by the population inhabitating around the study area. The data obtained from such study may be used locally to establish it and where the controls are needed. In the present study the most accurate Solid State Track Detector (SSNTD) method is used to determine the concentration of radon, thoron and their progeny. The maximum concentration of radon of 116.4 Bq.m-3 and gamma exposure rate of 765 n Gyh-1 have been observed in the dwellings at Champion place. The low concentration of radon and gamma exposure have been observed at Robersonpet and BGML nagar. (author)

  5. Clinical study of lesions caused by accidental local exposure to ionizing radiations

    International Nuclear Information System (INIS)

    During the last few years the radiopathology service of the Curie Foundation has admitted more than a hundred patients who were followed and treated for irradiation or suspected irradiation after a work accident. Accidents followed by clinical symptoms account for about half the cases examined. Some of these clinical signs were benign whereas others developed very seriously, all possible conditions between these two extremes being represented. This report neglects cases of high total exposure and deals only with those of partial irradiation where local symptoms predominate, usually at the distal extremities of the upper limbs and exceptionally at the root or distal extremity of the lower limbs. Six clinical cases were selected as particularly revealing and are discussed below: accidental exposure of both hands to an iridium-192 source; chronic exposure to X-rays (left hand and right lower half-lip); accidental exposure of the right hand and antero-external face of the right thigh to a iridium-192 source; acute accidental exposure of the left hand to X-rays emitted under 50 kV; accidental exposure of both hands to cobalt-60 radiation; radiolesions of the left lower limb following a critical power excursion (gamma rays and neutrons)

  6. Radiation exposures in reprocessing facilities at the Savannah River Plant

    International Nuclear Information System (INIS)

    Two large reprocessing facilities have been operating at the Savannah River Plant since 1955. The plant, which is near Aiken, South Carolina, is operated for the U.S. Department of Energy by the Du Pont Company. The reprocessing facilities have a work force of approximately 1,800. The major processes in the facilities are chemical separations of irradiated material, plutonium finishing, and waste management. This paper presents the annual radiation exposure for the reprocessing work force, particularly during the period 1965 through 1978. It also presents the collective and average individual annual exposures for various occupations including operators, mechanics, electricians, control laboratory technicians, and health physicists. Periodic and repetitive work activities that result in the highest radiation exposures are also described. The assimilation of radionuclides, particularly plutonium, by the work force is reviewed. Methods that have been developed to minimize the exposure of reprocessing personnel are described. The success of these methods is illustrated by experience - there has been no individual worker exposure of greater than 3.1 rems per year and only one plutonium assimilation greater than the maximum permissible body burden during the 24 years of operation of the facilities

  7. Risk from exposure to natural and artificial ultraviolet radiation

    International Nuclear Information System (INIS)

    The association between exposure to ultraviolet (UV) and damage to the skin and eyes is today generally accepted. Exposure to UV radiation may occur in several ways. Apart from the sun, there is a wide range of artificial sources used in different fields of industry, research and medicine, the exposure to which adds to the total exposure of an individual during his life-span. The potential effects of ozone layer depletion on the increase of the solar UV radiation at earth's surface, and therefor on human health, have recently been emphasized. Moreover, great attention has been devoted to the often uncontrolled use of UV lamps for tanning. This report shows the basis on which short and long term UV risk is assessed, and indicates some parameters necessary to its evaluation. The UV effects, both at molecular and cellular levels and on humans, are described together with their respective action spectra. The most common UV sources are then analyzed and their use in different fields is shown. Finally, some methods in dosimetry, which are useful for the correct measurement of exposure values, are described

  8. Radiation Exposure Monitoring and Information Transmittal (REMIT) system

    International Nuclear Information System (INIS)

    The Radiation Exposure Monitoring and Information Transmittal (REMIT) system is designed to assist US Nuclear Regulatory Commission (NRC)licensees in meeting the reporting requirements of the revised 10 CFR 20 and in agreement with the guidance contained in R.G. 8.7, Rev. 1, ''Instructions for Recording and Reporting Occupational Exposure Data.'' REMIT is a personal computer (PC) based menu driven system that facilitates the manipulation of data base files to record and report radiation exposure information. REMIT is designed to be user-friendly and contains the full text of R. G. 8.7, Rev. 1, on-line as well as context-sensitive help throughout the program. The user can enter data directly from NRC Forms 4 or 5, REMIT allows the user to view the individual's exposure in relation to regulatory or administrative limits and alerts the user to exposures in excess of these limits. The system also provides for the calculation and summation of dose from intakes and the determination of the dose to the maximally exposed extremity for the monitoring year. REMIT can produce NRC Forms 4 and 5 in paper and electronic format and can import/export data from ASCII and data base files

  9. Evaluation of radiation exposure from a consumer product. A pillow

    International Nuclear Information System (INIS)

    Radiation exposure from a pillow was analyzed. According to an advertisement of the pillow, this radioactive consumer product contains enough amounts of radioactive materials to induce radiation hormesis effects. The pillow consists of the filling chips made from kneading mineral ores and the polynosic linings contains natural radioactive ores. A γ-ray analysis of the pillow using pure Ge-MCA reveals that there exist radioactivities of thorium and uranium series mixtures in it at concentration of 0.58% by the weight. The observations of a chip surface by a scanning electron microscope show that the shapes of two sides are different each other. There are lots of sharp protuberances on the outside of the chip. To determine the direct external exposures from the pillow, film badges were placed on the pillow for 210 h and 2555 h. The dose equivalents of 210 h exposure was under 0.1 mSv which is a detection limit of a γ-ray by the film badges. However, that of 2555 h exposure was over 0.1 mSv less than 0.15 mSv. Quantities of internal exposures from inhalation of the vaporized Rn were measured by a Lucas Cell. It was 79 Bq/m3. There is no necessity for anxious about being broken in health inhaling the Rn-gass. (author)

  10. Radiation exposures in reprocessing facilities at the Savannah River Plant

    International Nuclear Information System (INIS)

    Two large reprocessing facilities have been operating at the Savannah River Plant since 1955. The plant, which is near Aiken, South Carolina, is operated for the US Department of Energy by the Du Pont Company. The reprocessing facilities have a work force of approximately 1,800. The major processes in the facilities are chemical separations of irradiated material, plutonium finishing, and waste management. This paper presents the annual radiation exposure for the reprocessing work force, particularly during the period 1965 through 1978. It also presents the collective and average individual annual exposures for various occupations including operators, mechanics, electricians, control laboratory technicians, and health physicists. Periodic and repetitive work activities that result in the highest radiation exposures are also described. The assimilation of radionuclides, particularly plutonium, by the work force is reviewed. Methods that have been developed to minimize the exposure of reprocessing personnel are described. The success of these methods is illustrated by experience - there has been no individual worker exposure of greater than 3.1 rems per year and only one plutonium assimilation greater than the maximum permissible body burden during the 24 years of operation of the facilities

  11. A reassessment of Galileo radiation exposures in the Jupiter magnetosphere

    International Nuclear Information System (INIS)

    Earlier particle experiments in the 1970's on Pioneer-10 and -11 and Voyager-1 and -2 provided Jupiter flyby particle data, which were used by Divine and Garrett to develop the first Jupiter trapped radiation environment model. This model was used to establish a baseline radiation effects design limit for the Galileo onboard electronics. Recently, Garrett et al. have developed an updated Galileo Interim Radiation Environment (GIRE) model based on Galileo electron data. In this paper, we have used the GIRE model to reassess the computed radiation exposures and dose effects for Galileo. The 34-orbit 'as flown' Galileo trajectory data and the updated GIRE model were used to compute the electron and proton spectra for each of the 34 orbits. The total ionisation doses of electrons and protons have been computed based on a parametric shielding configuration, and these results are compared with previously published results. Published by Oxford Univ. Press. All right reserved. (authors)

  12. Paternal exposure to radiation and offspring cancer in mice

    International Nuclear Information System (INIS)

    Parental exposure to radiation could induce various kinds of tumors in the next generation. In ICR mice, a large and significant increase of adult type tumor was observed in the F1 offspring after X-ray exposure at spermatozoa and spermatid stages, and less clear increase was observed after spermatogonial exposure. Mature oocytes were resistant up to 1 Gy, but very sensitive to tumor induction at higher doses. While there was no difference in the tumor incidence between acute and fractionated (0.36 Gy at 2 hr intervals) irradiation at post-gonial stages, a large reduction of tumor incidence was observed after spermatogonial and mature oocyte exposure, suggesting some repairs of X-ray damages in these germ cells. Acute lymphocytic leukemia was not induced in CCR and LT mice after spermatogonial exposure, while a larger increase of adult type cancers was observed in F1 offspring. However, 1.9-3.2 fold and 4.5-7.4 fold increases of leukemia incidence were observed in ICR and LT mice, when spermatozoa stage was treated with the X-ray doses of 0.36-5.04 Gy and 3.6-5.04 Gy, respectively, indicating the large difference in the sensitivity of developing germ cells to leukemia induction by radiation in the F1 offspring. In contrast to ICR and LT mice, N5 strain developed about 10 or 18 times higher incidence of leukemia in the offspring after spermatogonial or spermatozoa exposure to 5.04 Gy of X-rays, respectively, showing a marked difference in the sensitivity to the leukemia induction by radiation between mouse strains. These differential sensitivities between germ cell stages and also between mouse strains reconcile the difference between two population studies in Hiroshima/Nagasaki and Sellafield. However, there were large differences in the doubling doses for leukemia induction between the mouse experiments and Sellafield study in human. (author)

  13. Studies of effects of radiation exposure on children

    International Nuclear Information System (INIS)

    This review describes the title subject from the aspect of age difference in humans and experimental animals. Epidemiological studies on A-bomb survivors have revealed that the effects are dependent on the dose, sex, age at exposure and attained age after the exposure. Analysis of the survivor cohort shows that the younger is the age at exposure, the higher the risk of cancer death at an attained age. However, the risk is suggested small and insignificant regardless to the age of exposure at the low dose 0.005-0.5 Gy. The risk of carcinogenesis at the attained age 50 y of exposed children is 1.7 while that of exposed fetuses, 0.42. There are no confounding factors in animal experiments. Risks of carcinogenesis and life-span reduction have been found the highest in the exposed mouse neonate (0-7 days old). In authors' studies with gamma-ray, it is shown that females are more susceptible, the risk is the highest in 1 week old infants and is the lowest in fetuses at 17 days after gestation at <1 Gy dose. That the susceptible age to cancer formation differs on the organ is also shown, where at exposure to the late phase fetuses/neonates/infants, increased incidence of cancers thereafter is seen in the brain, kidney, liver, mammary gland, lung, gut and T-lymphocytes in contrast to adults in which the lung cancer and marrow leukemia are major. Carcinogenic radiation response of infant seems different from that of adult: after exposure, adult gut cells die due to the apoptosis through p53-Noxa-caspase pathway but at the developing age, p53-p21 pathway is activated leading to the arrest of cell cycle, resulting in survival of DNA-injured cells. Studies on the age difference of cancer formation is conceivably important for elucidation of radiation carcinogenesis for radiation protection and risk reduction. (T.T.)

  14. Accident of radiation exposure and/or contamination with radionuclide

    International Nuclear Information System (INIS)

    The accident of exposure is defined to be an unintentional one leading to deleterious outcome. This paper reviews the historical and recent accidents involving those mainly dealt in National Institute of Radiological Sciences (NIRS) in Japan and reported in foreign countries, and describes Japanese medical system for coping with the exposure. Hazardous events of radiation exposure are reported as early as within 1 year after discovery of X-ray by Roentgen (1895). In Japan, there are accidents of exposure to the crew of fishing boat Daigo Fukuryu Maru by nuclear experiment at Bikini Atoll (1954), of exposure by stolen 192Ir source (1972) and by Tokai Criticality Accident (1999). More recently, accidents dealt in NIRS are 13 incidents in 2000-2011: serious cases are 3 skin injuries of electronic industry workers by soft X-ray at 50-91 Gy (2000), and of a high school student at 9 Gy (2001) in the science lesson. The decontamination, dosimetry, radiological protection and support of temporary entrance of evacuees have been conducted by NIRS at Fukushima Nuclear Power Plant Accident (2011). Foreign information of 19 severely exposed accidents from 2000 to 2012 are described partly or thoroughly for 18 countries. In Japan, the medical system for coping with the exposure is now under re-construction on the impact of the Fukushima Accident. Its concept stands on the aspects that the system is essentially built up not only for prefectures having nuclear power plant and their neighboring ones, but also those with facilities dealing with radioisotopes, and that those undertaking subjects are thoroughly responsible for concurrent support of medicare at radiation emergency. The guideline for medical education published in 2011 contains the item concerning the radiation/humans. (T.T.)

  15. Occupational radiation exposure in Germany 2003. Report of the radiation protection register

    International Nuclear Information System (INIS)

    In Germany, persons occupationally exposed to radiation are monitored by six measurement points for personal doses and 30 measurement points for incorporation. The doses determined by these official measurement points are collected in the Radiation Protection Register, classifies by person. An important task of the Radiation Protection Register of the Federal Authority for Radiation Protection (paragraph 12 c AtG) is the supraregional and long-term monitoring of the compliance with dose limits in cases of occupational exposure, especially with regard to the occupational life time dose. Monitoring the issuance of the radiation pass belongs also to its tasks. One purpose of the Radiation Protection Register is to review the compliance with the radiation protection principles, i.e. ''dose limitation'' and ''minimization''. The annual evaluation of the exposure data of the persons monitored provide a differentiated broad picture of the present level and the development of the occupational radiation exposure thus being a good contribution to an efficient radiation protection and documentation the present situation of radiation protection in Germany. In 2003, the number of the persons monitored was ca. 315.000 thus having not changed over the past four years. Roughly 16% of the persons monitored took up a measurable whole body dose in 2003. In the time between 1999 and 2003, the average yearly dose of these persons was reduced by almost one third. The yearly average dose of these persons in 2003 is around 0,90 mSv equalling 5% of the new yearly dose limit. And this is the lowest value ever since the monitoring of the occupational radiation exposure was started

  16. Sub-chronic exposure to second hand smoke induces airspace leukocyte infiltration and decreases lung elastance

    Directory of Open Access Journals (Sweden)

    John M. Hartney

    2012-07-01

    Full Text Available Exposure to second hand tobacco smoke is associated with the development and/or exacerbation of several different pulmonary diseases in humans. To better understand the possible effects of second hand smoke exposure in humans, we sub-chronically (4 weeks exposed mice to a mixture of mainstream and sidestream tobacco smoke at concentrations similar to second hand smoke exposure in humans. The inflammatory response to smoke exposures was assessed at the end of this time by enumeration of pulmonary leukocyte infiltration together with measurements of lung elastance and pathology. This response was measured in both healthy wild type (C57BL/6 mice as well as mouse mutants deficient in the expression of Arhgef1 (Arhgef1–/– that display constitutive pulmonary inflammation and decreased lung elastance reminiscent of emphysema. The results from this study show that sub-chronic second hand smoke exposure leads to significantly increased numbers of airspace leukocytes in both healthy and mutant animals. While sub-chronic cigarette smoke exposure is not sufficient to induce changes in lung architecture as measured by mean linear intercept, both groups exhibit a significant decrease in lung elastance. Together these data demonstrate that even sub-chronic exposure to second hand smoke is sufficient to induce pulmonary inflammation and decrease lung elastance in both healthy and diseased animals and in the absence of tissue destruction.

  17. Assessment of genetic risk for human exposure to radiation

    International Nuclear Information System (INIS)

    Full text: The methodology of assessing the genetic risk of radiation exposure is based on the concept of 'hitting the target' in development of which N.V. Timofeeff-Ressovsky has played and important role. To predict genetic risk posed by irradiation, the U N Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) has worked out direct and indirect methods of assessment, extrapolation, integral and palpitation criteria of risk analysis that together permit calculating the risk from human exposure on the basis of data obtained for mice. Based on the reports of UNSCEAR for the period from 1958 to 2001 the paper presents a retrospective analysis of the use of direct methods and the doubling dose method for quantitative determination of the genetic risk of human exposure expressed as different hereditary diseases. As early as 1962 UNSCEAR estimated the doubling dose (a dose causing as many mutations as those occurring spontaneously during one generation) at 1 Gy for cases of exposure to ionizing radiations with low LET at a low dose rate and this value was confirmed in the next UNSCEAR reports up to now. For cases of acute irradiation the doubling dose was estimated at 0,3-0,4 Gy for the period under review. The paper considers the evolution of the concepts of human natural hereditary variability which is a basis for assessing the risk of exposure by the doubling dose method. The level of human natural genetic variability per 1 000 000 newborns is estimated at 738 000 hereditary diseases including mendelian, chromosomal and multifactorial ones. The greatest difficulties in assessing the doubling dose value were found to occur in the case of multifactorial diseases the pheno typical expression of which depends on mutational events in polygenic systems and on numerous environmental factors. The introduction in calculations of the potential recoverability correction factor (RPCF) made it possible to assess the genetic risk taking into account this class of

  18. Occupational radiation exposure to norms in a gold mine

    International Nuclear Information System (INIS)

    Preliminary studies have been conducted into the occupational radiation exposure to NORMS from surface and underground mining operations in a gold mine in the Ashanti Region of Ghana. A brief description of the methods and instrumentation is presented. The annual effective dose has been estimated to be 0.26 ± 0.11 mSv for surface mining and 1.83 ± 0.56 mSv for the underground mines using the ICRP dose calculation method. The results obtained are found to be within the allowable limit of 20 mSv per annum for occupational exposure control recommended by the ICRP. (authors)

  19. Modern therapy of chronic wounds with respect to radiation

    International Nuclear Information System (INIS)

    Background: Descriptions of wound care techniques have been found in some of the oldest archeological findings and chronic wounds have been threading man thousands of years. However, only in the last few decades substantial progress has been made in understanding the cellular and biochemical processes relevant in normal healing. Pathophysiology: Wound healing is a complex process involving a variety of different cells, proteins, chemoattractants, proteinases and growth factors. The normal repair process is a coordinated cellular and biochemical event and can be characterized by 3 different healing phases (inflammatory, proliferative, and remodeling phase). Certain pathophysiologic conditions and metabolic disorders alter this preprogrammed course, leading to delayed healing or chronic nonhealing wounds. Disturbance of wound healing after radiation: Especially irradiation can complicate tissue repair and surgical wound healing. Therefore this article will review the basic understanding of the wound healing process and the knowledge of modern surgical and conservative wound therapy from a surgical point of view, which is essential to surpass pathophysiological situations and avoid chronic wounds. (orig.)

  20. Study Regarding Electromagnetic Radiation Exposure Generated By Mobile Phone

    Science.gov (United States)

    Marica, Lucia; Moraru, Luminita

    2011-12-01

    Number of mobile phone users reached to 5 billion subscribers in 2010 [ABI Research, 2010]. A large number of studies illustrated the public concern about adverse effects of mobile phone radiation and possible health hazards. Position of mobile phone use in close proximity to the head leads the main radiation between the hand and the head. Many investigations studying the possible effects of mobile phone exposure, founded no measurable effects of short-term mobile phone radiation, and there was no evidence for the ability to perceive mobile phone EMF in the general population. In this study, field radiation measurements were performed on different brand and different models of mobile phones in active mode, using an EMF RF Radiation Field Strength Power Meter 1 MHz-8 GHz. The study was effectuated on both the 2G and 3G generations phones connected to the providers operating in the frequency range 450 MHz-1800 MHz. There were recorded values in outgoing call and SMS mode, incoming call and SMS mode. Results were compared with ICNIRP guidelines for exposure to general public.