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Sample records for chronic atrophic gastritis

  1. Prof.Shan Zhaowei's Experience in Treating Chronic Atrophic Gastritis

    Institute of Scientific and Technical Information of China (English)

    吴连恩; 杨建平

    2004-01-01

    @@ Having been engaged in clinical practice for 40 years,Prof. Shah Zhaowei of Jiangsu Provincial Hospital of Traditional Chinese Medicine is good at treating chronic atrophic gastritis (CAG). In clinical practice,he often pays great attention to the combination of TCM syndrome-differentiation with diseasedifferentiation as well as the combination of macroscopic differentiation with microscopic differentiation. The therapeutic method he adopts or the drugs he prescribes are both simple and clear,often leading to remarkably therapeutic results. The following is a brief introduction to his clinical experience on the treatment of chronic atrophic gastritis (CAG).

  2. Chronic atrophic gastritis in association with hair mercury level.

    Science.gov (United States)

    Xue, Zeyun; Xue, Huiping; Jiang, Jianlan; Lin, Bing; Zeng, Si; Huang, Xiaoyun; An, Jianfu

    2014-11-01

    The objective of this study was to explore hair mercury level in association with chronic atrophic gastritis, a precancerous stage of gastric cancer (GC), and thus provide a brand new angle of view on the timely intervention of precancerous stage of GC. We recruited 149 healthy volunteers as controls and 152 patients suffering from chronic gastritis as cases. The controls denied upper gastrointestinal discomforts, and the cases were diagnosed as chronic superficial gastritis (n=68) or chronic atrophic gastritis (n=84). We utilized Mercury Automated Analyzer (NIC MA-3000) to detect hair mercury level of both healthy controls and cases of chronic gastritis. The statistic of measurement data was expressed as mean ± standard deviation, which was analyzed using Levene variance equality test and t test. Pearson correlation analysis was employed to determine associated factors affecting hair mercury levels, and multiple stepwise regression analysis was performed to deduce regression equations. Statistical significance is considered if p value is less than 0.05. The overall hair mercury level was 0.908949 ± 0.8844490 ng/g [mean ± standard deviation (SD)] in gastritis cases and 0.460198 ± 0.2712187 ng/g (mean±SD) in healthy controls; the former level was significantly higher than the latter one (p=0.000Pearson correlation analysis indicated that eating seafood was most correlated with hair mercury level and positively correlated in the healthy controls and that the severity of gastritis was most correlated with hair mercury level and positively correlated in the gastritis cases. Multiple stepwise regression analysis indicated that the regression equation of hair mercury level in controls could be expressed as 0.262 multiplied the value of eating seafood plus 0.434, the model that was statistically significant (p<0.01). Multiple stepwise regression analysis also indicated that the regression equation of hair mercury level in gastritis cases could be expressed as 0

  3. Protective Action of Acupuncture and Moxibustion on Gastric Mucosa in Model Rats with Chronic Atrophic Gastritis

    Institute of Scientific and Technical Information of China (English)

    高希言; 饶红; 王燕; 孟丹; 魏玉龙

    2005-01-01

    Objective: To probe the mechanism of acupuncture and moxibustion in atrophic gastritis so as to provide a basis for clinical treatment. Method: Observe the effects of acupuncture and moxibustion at the points of Zusanli, Zhongwan and Tianshu on gastric mucosa in model rats with chronic atrophic gastritis. Results:Acupuncture and moxibustion can increase the contents of PGE2α, PGF2α and cAMP, and decrease the content of cGMP in the tissue of gastric mucosa. Conclusion: Acupuncture and moxibustion shows cytoprotection on gastric mucosa, so it is an effective method for treating chronic atrophic gastritis.

  4. Comparative proteomics analysis of chronic atrophic gastritis: changes of protein expression in chronic atrophic gastritis with out Helicobacter pylori infection

    International Nuclear Information System (INIS)

    Chronic atrophic gastritis (CAG) is a very common gastritis and one of the major precursor lesions of gastric cancer, one of the most common cancers worldwide. The molecular mechanism underlying CAG is unclear, but its elucidation is essential for the prevention and early detection of gastric cancer and appropriate intervention. A combination of two-dimensional gel electrophoresis and mass spectrometry was used in the present study to analyze the differentially expressed proteins. Samples from 21 patients (9 females and 12 males; mean age: 61.8 years) were used. We identified 18 differentially expressed proteins in CAG compared with matched normal mucosa. Eight proteins were up-regulated and 10 down-regulated in CAG when compared with the same amounts of proteins in individually matched normal gastric mucosa. Two novel proteins, proteasome activator subunit 1 (PSME1), which was down-regulated in CAG, and ribosomal protein S12 (RPS12), which was up-regulated in CAG, were further investigated. Their expression was validated by Western blot and RT-PCR in 15 CAG samples matched with normal mucosa. The expression level of RPS12 was significantly higher in CAG than in matched normal gastric mucosa (P < 0.05). In contrast, the expression level of PSME1 in CAG was significantly lower than in matched normal gastric mucosa (P < 0.05). This study clearly demonstrated that there are some changes in protein expression between CAG and normal mucosa. In these changes, down-regulation of PSME1 and up-regulation of RPS12 could be involved in the development of CAG. Thus, the differentially expressed proteins might play important roles in CAG as functional molecules

  5. Comparative proteomics analysis of chronic atrophic gastritis: changes of protein expression in chronic atrophic gastritis with out Helicobacter pylori infection

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    Zhang, Lin; Hou, Yanhong; Wu, Kai; Li, Dan [Department of Gastroenterology and Hepatology, The 309 Hospital of People' s Liberation Army, Beijing (China)

    2012-03-02

    Chronic atrophic gastritis (CAG) is a very common gastritis and one of the major precursor lesions of gastric cancer, one of the most common cancers worldwide. The molecular mechanism underlying CAG is unclear, but its elucidation is essential for the prevention and early detection of gastric cancer and appropriate intervention. A combination of two-dimensional gel electrophoresis and mass spectrometry was used in the present study to analyze the differentially expressed proteins. Samples from 21 patients (9 females and 12 males; mean age: 61.8 years) were used. We identified 18 differentially expressed proteins in CAG compared with matched normal mucosa. Eight proteins were up-regulated and 10 down-regulated in CAG when compared with the same amounts of proteins in individually matched normal gastric mucosa. Two novel proteins, proteasome activator subunit 1 (PSME1), which was down-regulated in CAG, and ribosomal protein S12 (RPS12), which was up-regulated in CAG, were further investigated. Their expression was validated by Western blot and RT-PCR in 15 CAG samples matched with normal mucosa. The expression level of RPS12 was significantly higher in CAG than in matched normal gastric mucosa (P < 0.05). In contrast, the expression level of PSME1 in CAG was significantly lower than in matched normal gastric mucosa (P < 0.05). This study clearly demonstrated that there are some changes in protein expression between CAG and normal mucosa. In these changes, down-regulation of PSME1 and up-regulation of RPS12 could be involved in the development of CAG. Thus, the differentially expressed proteins might play important roles in CAG as functional molecules.

  6. Clinical Research on Acupuncture and Moxibustion Treatment of Chronic Atrophic Gastritis

    Institute of Scientific and Technical Information of China (English)

    Gao Xiyan; Yuan Jing; Li Huijuan; Ren Shan

    2007-01-01

    Objective: To observe the clinical therapeutic effects of acupuncture and moxibustion in treating chronic atrophic gastritis. Methods: Patients who met the criteria were randomly divided into the treatment groups consisting of the acupuncture group (30 cases) and the acupuncture-moxibustion group (30 cases), and the control group (28 cases). After two months of treatment, observed were safety and the curative effects,through general physical check ups, routine examinations of blood, urine and feces, and symptoms,pathology and gastrin before, during and after the treatment. Results: 1) The treatment groups showed significant superiorities in the improvement of symptoms, with the acupuncture-moxibustion group showing the best therapeutic effects. 2) The acupuncture-moxibustion group showed marked differences before and after the treatment in the improvement of glandular atrophy and intestinal metaplasia, with a total effective rate of 66.67%. 3) After the treatment, the three groups all showed marked improvement in the level of serum gastrin, with the acupuncture-moxibustion group showing the best effects. Conclusion: Acupuncture and moxibustion have definite therapeutic effects for chronic atrophic gastritis, especially in improving the symptoms. Acupuncture or acupuncture combined with moxibustion can provide possibilities in reversing the pathologic changes of glandular atrophy and intestinal metaplasia for patients with chronic atrophic gastritis. Acupuncture-moxibustion is really an effective and safe therapy for chronic atrophic gastritis.

  7. Efficacy of tepronone and folic acid in the treatment of chronic atrophic gastritis evaluated by the marking targeting biopsy

    Institute of Scientific and Technical Information of China (English)

    裘力锋

    2013-01-01

    Objective To explore the efficacy of tepronone and folic acid in the treatment of chronic atrophic gastritis(CAG) evaluated by the marking targeting biopsy(MTB).Methods A total of 224 H.pylori negative

  8. Effects of He-Ne laser irradiation on chronic atrophic gastritis in rats

    Institute of Scientific and Technical Information of China (English)

    Xue-Hui Shao; Yue-Ping Yang; Jie Dai; Jing-Fang Wu; Ai-Hua Bo

    2005-01-01

    AIM: To study the effects of He-Ne laser irradiation on experimental chronic atrophic gastritis (CAG) in rats.METHODS: Sixty-three male adult Wistar rats were randomly divided into five groups including normal control group, model control group and three different dosages He-Ne laser groups. The chronic atrophic gastritis (CAG)model in rats was made by pouring medicine which was a kind of mixed liquor including 2% sodium salicylate and 30% alcohol down the throat for 8 wk to stimulate rat gastric mucosa, combining with irregular fasting and compulsive sporting as pathogenic factors; 3.36, 4.80, and 6.24J/cm2doses of He-Ne laser were used, respectively for three different treatment groups, once a day for 20 d. The pH value of diluted gastric acid was determined by acidimeter,the histopathological changes such as the inflammatory degrees in gastric mucosa, the morphology and structure of parietal cells were observed, and the thickness of mucosa was measured by micrometer under optical microscope.RESULTS: In model control group, the secretion of gastric acid was little, pathologic morphological changes in gastric mucosa such as thinner mucous, atrophic glands, notable inflammatory infiltration were found. After 3.36 J/cm2 dose of He-Ne laser treatment for 20 d, the secretion of gastric acid was increased (P<0.05), the thickness of gastric mucosa was significantly thicker than that in model control group (P<0.01), the gastric mucosal inflammation cells were decreased (P<0.05). Morphology, structure and volume of the parietal cells all recuperated or were closed to normal.CONCLUSION: 3.36J/cm2 dose of He-Ne laser has a significant effect on CAG in rats.

  9. Association of tumor necrosis factor genetic polymorphism with chronic atrophic gastritis and gastric adenocarcinoma in Chinese Han population

    Institute of Scientific and Technical Information of China (English)

    Bao-Ying Fei; Bing Xia; Chang-Sheng Deng; Xiao-Qing Xia; Min Xie; J Bart A Crusius; A Salvador Pena

    2004-01-01

    AIM: To investigate the association of TNF polymorphisms with chronic atrophic gastritis (CAG) and gastric adenocarcinoma in Chinese Han patients.METHODS: The TNFa-e 5 microsatellites and 3 RFLP sites were typed using PCR technique, followed by high-voltage denaturing PAGE with silver staining and restriction enzyme digestion respectively in specimens from 53 patients with CAG and 56 patients with gastric adenocarcinoma and 164 healthy controls. The PCR products were cloned and sequenced.RESULTS: The frequency of TNF-β Ncol*1/2 genotype was higher in patients with chronic atrophic gastritis than in healthy controls, but no significant difference was observed (60.38% vs 46.34%, P=0.076). The frequency of TNa10 allele was significantly higher in patients with chronic atrophic gastritis than in healthy controls (19.81% vs 11.89%,P=0.04). However, it did not relate to age, gender, atrophic degree or intestinal metaplasia in patients with chronic atrophic gastritis. The frequency of TNF-β Ncol*1/2 and d2/d6 genotypes were significantly higher in patients with gastric adenocarcinoma than in healthy individuals(P>0.05).However, TNF-β Ncol*1/2 and d2/d6 genotypes did not relate to age, gender, grade of differentiation and clinicopathologic stage in patients with gastric adenocarcinoma. The frequency of TNFa6b5c1 haplotype homozygote was significantly lower in patients with gastric adenocarcinoma than in healthy controls (1.79% vs15.85%, P=0.006).CONCLUSION: TNFa10 allele may be a risk factor for chronic atrophic gastritis. TNF-β Ncol*1/2 and d2/d6 genotypes are associated with the susceptibility to gastric adenocarcinoma,whereas TNFa6b5c1 haplotype homozygote may contribute to the resistance against gastric adenocarcinoma.

  10. Risk for gastric neoplasias in patients with chronic atrophic gastritis: A critical reappraisal

    Institute of Scientific and Technical Information of China (English)

    Lucy Vannella; Edith Lahner; Bruno Annibale

    2012-01-01

    Chronic atrophic gastritis (CAG) is an inflammatory condition characterized by the loss of gastric glandular structures which are replaced by connective tissue (non-metaplastic atrophy) or by glandular structures inappropriate for location (metaplastic atrophy).Epidemiological data suggest that CAG is associated with two different types of tumors:Intestinal-type gastric cancer (GC) and type Ⅰ gastric carcinoid (T I GC).The pathophysiological mechanisms which lead to the development of these gastric tumors are different.It is accepted that a multistep process initiating from Helicobacterpylori-related chronic inflammation of the gastric mucosa progresses to CAG,intestinal metaplasia,dysplasia and,finally,leads to the development of GC.The T I GC is a gastrin-dependent tumor and the chronic elevation of gastrin,which is associated with CAG,stimulates the growth of enterochromaffin-like cells with their hyperplasia leading to the development of T I GC.Thus,several events occur in the gastric mucosa before the development of intestinal-type GC and/or T I GC and these take several years.Knowledge of CAG incidence from superficial gastritis,its prevalence in different clinical settings and possible risk factors associated with the progression of this condition to gastric neoplasias are important issues.This editorial intends to provide a brief review of the main studies regarding incidence and prevalence or CAG and risk factors for the development of gastric neoplasias.

  11. Body mass index, chronic atrophic gastritis and heartburn: a population-based study among 8936 older adults from Germany

    OpenAIRE

    Gao, Lei; Weck, Melanie Nicole; Rothenbacher, Dietrich; Brenner, Hermann

    2010-01-01

    Abstract Background: Obesity and overweight have been positively related to gastroesophageal reflux disease (GERD). It has been suggested, that this relation is due to an increased gastric acid reflux which is caused by an enhanced intra-abdominal pressure. Aim: We aimed to assess potential interaction of the association between body mass index (BMI) and GERD by chronic atrophic gastritis (CAG) which goes along with reduced acid production. Methods: In the baseline examinat...

  12. Caveolin-1, E-cadherin and β-catenin in Gastric Carcinoma, Precancerous Tissues and Chronic Non-atrophic Gastritis

    Institute of Scientific and Technical Information of China (English)

    Guo-yang Sun; Jun-xia Wu; Jian-sheng Wu; Yu-ting Pan; Rong Jin

    2012-01-01

    Objective:To investigate the expressions of caveolin-1,E-cadherin and β-catenin in gastric carcinoma,precancerous gastric and chronic non-atrophic gastritis tissues,and evaluate the correlation of these expressions with the development of gastric cancer.Methods:The expressions of caveolin-1,E-cadherin and β-catenin were detected by biotin-streptavidinperoxidase (SP) immunohistochemistry on 58 gastric cancer tissues,40 precancerous gastric tissues and 42 chronic non-atrophic gastritis tissues.The correlation between the expressions of caveolin-1,E-cadherin and β-catenin,and the clinicopathologic parameters of gastric cancer was analyzed retrospectively.Results:The positive rates of caveolin-1 and E-cadherin expressions in gastric carcinoma were significantly lower than precancerous gastric and chronic non-atrophic gastritis tissues (P<0.01).An abnormal rate of β-catenin expression in gastric carcinoma was higher than precancerous gastric and chronic non-atrophic gastritis tissues (P<0.01).Moreover,low expressions of caveolin-1,E-cadherin and β-catenin correlated with tumor size,depth of invasion,lymph node metastasis and TNM stage (P<0.05).The positive rates of caveolin-1 and E-cadherin expressions decreased (P<0.01),while an abnormal rate of β-catenin expression increased inversely,with the degree of atypical hyperplasia (P<0.01).Caveolin-1 expression correlated positively with E-cadherin (r=0.41,P<0.05).Caveolin-1 (r=-0.36,P<0.05) and E-cadherin (r=-0.45,P<0.05) expressions negatively correlated with abnormal β-catenin expression.Conclusion:These results suggested that dysregulated expressions of caveolin-1,E-cadherin and β-catenin correlated with the development of gastric cancer and its biological behavior.

  13. Broccoli consumption and chronic atrophic gastritis among Japanese males: an epidemiological investigation.

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    Sato K

    2004-06-01

    Full Text Available Previous in vitro and animal experiments have shown that sulforaphane, which is abundant in broccoli, inhibits Helicobacter pylori (H. pylori infection and blocks gastric tumor formation. This suggests that broccoli consumption prevents chronic atrophic gastritis (CAG introduced by H. pylori infection and, therefore, gastric cancer. For an epidemiological investigation of the relationship between the broccoli consumption and CAG, a cross-sectional study of 438 male employees, aged 39 to 60 years, of a Japanese steel company was conducted. CAG was serologically determined with serum cut-off values set at pepsinogen I < or = 70 ng/ml and a ratio of serum pepsinogen I/pepsinogen II < or = 3.0. Broccoli consumption (weekly frequency and diet were monitored by using a 31-item food frequency questionnaire. The prevalence of CAG among men who ate broccoli once or more weekly was twice as high as that among men who consumed a negligible amount (P < 0.05. Multiple logistic regression analysis indicated that broccoli consumption once or more weekly significantly increased the risk for CAG (odds ratio, 3.06; 95% confidence interval, 1.12-8.38; P < 0.05, after controlling for age, education, cigarette smoking, and alcohol consumption. The present study failed to show an expected association between frequent broccoli consumption and a low prevalence of CAG.

  14. Expression of growth hormone and its receptor in chronic atrophic gastritis and its clinical significance

    Institute of Scientific and Technical Information of China (English)

    Jian-Min Si; Qian Cao; Min Gao

    2004-01-01

    AIM: To investigate the growth hormone (GH) and growth hormone receptor (GHR) expression of and its clinical significance in patients with chronic atrophic gastritis (CAG).METHODS:A total of 90 cases were enrolled in the study.Thirty were healthy controls,the other 60 patients were divided into two groups according to the endoscopical and histological diagnosis.Blood samples were drawn in the morning (menarche did not occur during the blood extraction in female patients),gastric mucosa was obtained by endoscopy.Serum GH and gastrice mucosal GHR levels were measured using radioimmunoassay (RIA) and En Vinsion technique.RESULTS:The average GH level was 1.021±0.132μ/L in CAG patients,in controls it was 2.869 0.512μ/L.There was a significant difference between these two groups(P<0.01).The positive rate of GHR in CAG patients was 10%,in controls the rate was 100%.There was a significant difference (P<0.01).There was no significant change of GH level (3.176±0.421μ/L) in patients with gastric carcinoma compared with controls (P>0.05).CONCLUSION:The study shows that levels of GH and GHR expression are low in CAG patients.CAG pathogenesis has a correlation with mucosal nutrient deficiency,decreased levels of GH and GHR have an adverse effect on the repair and regeneration of CAG.There is no significant change of GH in gastric carcinorma patients,GH dose not play a role in the pathogenesis of gastric cancer.

  15. Effect of Hewei-Decoction on chronic atrophic gastritis and eradication of Helicobacter pylori

    Institute of Scientific and Technical Information of China (English)

    Wan-Sheng Ji; Zhi-Xing Gao; Kai-Chun Wu; Jun-Wen Qiu; Bing-Long Shi; Dai-Ming Fan

    2005-01-01

    AIM: To demonstrate the effect of Hewei-Decoction(Decoction for regulating the stomach) on chronic atrophic gastritis (CAG) and eradication of Helicobacter pylori.METHODS: Ninety patients with CAG entering the investigation were divided into six differentiation syndromes, based on their major symptoms and signs.Hewei-Decoction was taken by all the patients orally for 4or 8 wk. The efficacy was assessed by both the composite accumulation of reduced scores of major symptoms and the eradication of H pylori.χ2 test was used to compare the efficacy between Hpylori-positive and negative cases,and to disclose the relationship between efficacy and eradication of H pylori.REStULTS: In patients with six different syndrome types,the efficacy of Hewei-Decoction was 91.67% (11/12),92.86% (13/14), 97.22% (35/36), 87.50% (14/16),75.00% (6/8), 75.00% (3/4) respectively. The rate of highly efficacious was 58.33% (7/12), 50.00% (7/14),77.78% (28/36), 62.50% (10/16), 12.50% (1/8) and25.00% (1/4), respectively. The total efficacy was 91.11%(82/90), and the rate of highly efficacious was 60.00%(54/90). The eradication rate of H pyloriwas 67.86%(38/56). The therapeutic effect of Hewei-Decoction was better in H pylori positive cases than that in Hpylori-negative cases with the total effect of 96.43% vs82.35% (P<0.05).In 56 H pylori positive cases, the therapeutic effect was better in H pylori eradicated cases than that in H pyloriexistent cases with the total effect of 97.37% vs 72.22%(P<0.01).CONCLUSION: Hewei-Decoction is effective in most cases of all the syndrome types. The results indicate that eradication of H pylori is one of the important mechanisms for alleviation of symptoms and signs. Also, the decoction is efficacious in H pylori-negative cases.

  16. Upregulation of cathepsin W-expressing T cells is specific for autoimmune atrophic gastritis compared to other types of chronic gastritis

    Institute of Scientific and Technical Information of China (English)

    Doerthe Kuester; Michael Vieth; Ulrich Peitz; Stefan Kahl; Manfred Stolte; Albert Roessner; Ekkehard Weber; Peter Malfertheiner; Thomas Wex

    2005-01-01

    AIM: To investigate a pathophysiological role of cathepsin W (CatW), a putative thiol-dependent cysteine protease,which is specifically expressed in cytotoxic lymphocytes,in different types of chronic inflammation of the gastric mucosa.METHODS: Gastric and duodenal biopsies of patients with Helicobacter pylori ( H pylori)-associated active gastritis ( Hp,n = 19), chemically induced reactive gastritis (CG, n = 17),autoimmune atrophic gastritis (AIG, n = 20), lymphocytic corpus gastritis (LG, n = 29), celiac disease (CD, n = 10),and corresponding controls (n = 24) were analyzed by immunohistochemistry for the expression of CatW and CD45. Furthermore, immunohistochemical double staining with anti-CD3 and anti-cathepsin was performed for the samples of AIG.RESULTS: Median values of CatW-expressing cells among CD45-positive immune cells were between 2% and 6% for normal gastric mucosa, CG, and LG, whereas the corresponding value was significantly increased for AIG (24.7%, P<0.001) and significantly decreased for HP (0.7%, P<0.05). Double staining with anti-CD3 and antiCatW antibodies revealed that >90% of CatW-expressing cells in gastric mucosa of AIG were T cells. Duodenal mucosa had significantly more CatW/CD45-positive cells than normal gastric mucosa (median: 17.8% vs 2%, P<0.01).The corresponding proportion of CatW/CD45-positive cells was decreased in CD compared to duodenal mucosa (median: 2.1% vs 17.8%, P<0.05).CONCLUSION: The opposite findings regarding the presence of CatW-positive cells in AIG (increase) and CD (decrease) reflects the different cellular composition of immune cells involved in the pathogenesis of these diseases.

  17. Morphological and pathologic changes of experimental chronic atrophic gastritis (CAG) and the regulating mechanism of protein expression in rats

    Institute of Scientific and Technical Information of China (English)

    WANG Liang-jing; CHEN Shu-jie; CHEN Zhe; CAI Jian-ting; SI Jian-min

    2006-01-01

    Objective: To study the pathologic change and molecular regulation in cell proliferation and apoptosis of gastric mucosa in rats with chronic atrophic gastritis (CAG), and evaluate the possible mechanisms. Methods: Rats were administered with 60% alcohol or 2% salicylate sodium, 20 mmol/L deoxycholate sodium and 0.1% ammonia water to establish chronic atrophic gastritis (CAG) models. The gastric specimens were prepared for microscopic view with hematoxylin and eosin (H-E)and alcian blue (A-B) stain. The number of infiltrated inflammatory cells, the thickness of the mucosa gland layer (μm) and the number of gastric glands were calculated. The damage of barrier in mucosa with erosion or ulceration, and the thickness of mucin were examined by scanned electron microscope (SEM). The levels of PGE2, EGF (epiderminal growth factor) and gastrin in the serum were measured with radioimmunoassay or ELISA method. The immunohistochemistry method was used to observe the number of G cells, the expression of protein of EGFR (EGF receptor), C-erbB-2, p53, p16 and bcl-2 in gastric tissue. Results:Under SEM observation, the gastric mucosa was diffused erosion or ulceration and the thickness of mucin was decreased. Compared with normal rats, the grade of inflammatory cell infiltration in CAG rats was elevated, whereas the thickness and number of gastric gland were significantly lower (P<0.05). Compared with normal level of (0.61+0.28) μg/L, EGF in CAG (2.2±0.83) μg/L was significantly higher (P<0.05). The levels of PGE2 and gastrin in serum were significantly lower in CAG rats than that in normal rats (P<0.05). Immunohistochemistry detection showed that the number of G cell in antrum was lower in CAG group (P<0.05). Immuno-stain showed EGFR protein expression in the basal and bilateral membrane, and the cytoplasma in atrophic gastric gland, while negative expression was observed in normal gastric epithelial cells. Positive staining of p53 and p16 protein was localized in

  18. [Mining analysis and experience summary for chronic atrophic gastritis cases treated by Professor LIU Feng-bin].

    Science.gov (United States)

    Hou, Zheng-kun; Liu, Feng-bin; Li, Pei-wu; Zhuang, Kun-hai

    2015-06-01

    To summarize Professor LIU Feng-bin's clinical experience and theoretical thoughts on chronic atrophic gastritis (CAG), the study group designed a retrospective study on his case series and expert interview. First of all, the data of CAG patients treated in the First Affiliated Hospital of Guangzhou University of Chinese Medicine between 2009 and 2013, e. g. herbs, diseases, syndrome type, prescription amount and number of herbs, was collected and processed. The statistical description and binary logistic regression were used to determined the syndrome type, initial basic remedy and modification. During the statistics, a complete and sub-group analysis was performed simultaneously. After the expert interview, the syndrome type and medication were finalized. As a result, a total of 228 CAG patients aged at (50.30 ± 10.18) were collected, including 151 males (66.23%). Of them, the TCM diagnosis and syndrome type were extracted from the information of 157 patients, including 115 cases with gastric stuffiness, 23 cases with gastric pain, 19 missing cases, 2 cases with spleen-stomach weakness syndrome, 57 cases with spleen deficiency and dampness-heat syndrome, 18 cases with spleen-stomach disharmony syndrome, 23 cases with syndrome of liver depression syndrome, 21 cases with liver qi invading stomach syndrome and 26 qi and yin deficiency syndrome, respectively. All of the 228 patients used totally 104 herbs, while the subgroups with 157 patients used 94 herbs. The most frequently used 15 herbs used in each groups were analyzed to determine the initial basic remedy and modification. Subsequently, based on the information of the sub-groups with 157 patients, with the syndrome type as the dependent variable, the logistic regression analysis was made on the most frequently used 32 herbs, in order to determined the modification in herbs for different syndrome types. After experts reviewed and modified, they believed the main causes of CAG were dietary irregularities

  19. Relationship between chronic atrophic gastritis and megaloblastic anemia%慢性萎缩性胃炎与巨幼细胞贫血的相关性

    Institute of Scientific and Technical Information of China (English)

    刘欣; 张晓敏; 龚均

    2012-01-01

    目的 探讨慢性萎缩性胃炎与巨幼细胞贫血发生的相关性,同时观察幽门螺杆菌(Hp)感染对巨幼细胞贫血发生的影响.方法 检测117例慢性胃炎(包括萎缩性与非萎缩性)患者(其中不伴巨幼细胞贫血者55例,伴巨幼细胞贫血者62例)血清胃蛋白酶原(pepsinogen,PG)Ⅰ、PGⅡ、维生素B12及叶酸水平.Hp经13C呼气试验及快速尿素酶法检测.结果 慢性萎缩性胃炎伴巨幼细胞贫血组血清PGⅠ、PGⅡ、PGⅠ/PGⅡ水平明显低于非贫血组(P<0.05),尤其以胃窦胃体萎缩为著(P<0.05).伴巨幼细胞贫血组中,萎缩性胃炎组血清维生素B12及叶酸水平均低于非萎缩性胃炎组(P<0.05);胃窦胃体萎缩组中血清维生素B12水平低于胃窦萎缩组(P<0.05).在萎缩性胃炎与非萎缩性胃炎中,Hp阳性组血清维生素B12水平较Hp阴性组均明显降低(P<0.05).结论慢性萎缩性胃炎与巨幼细胞贫血可能相互作用、互为因果;Hp感染可促进萎缩性胃炎的发生,同时会影响维生素B12及叶酸的吸收,间接导致巨幼细胞贫血的发生.%Objective To investigate the relationship between chronic atrophic gastritis and megaloblastic anemia, and to explore the effect of Hp infection on megaloblastic anemia. Methods A total of 117 patients with chronic gastritis diagnosed by gastroendoscopy were obtained, including 62 patients with megaloblastic anemia and 55 patients without megaloblastic anemia. Hp status was determined by 13C-urea breath test and urea enzymes test. Serum pepsinogen( PG ) Ⅰ and PG Ⅱ were detected by immunoturbidimetric assay. Vitamin B12 and folic acid levels were detected by electrochemiluminescence method. Results In chronic atrophic gastritis, PG Ⅰ , PG Ⅱ and PG Ⅰ /PG Ⅱ were decreased in patients with megaloblastic anemia compared with the patients without megaloblastic anemia( P < 0.05 ). PG Ⅰ level,PG Ⅰ /PG Ⅱ in antral and body atrophic gastritis with megaloblastic anemia were

  20. How to assess the severity of atrophic gastritis

    Institute of Scientific and Technical Information of China (English)

    Yan-Cheng Dai; Zhi-Peng Tang; Ya-Li Zhang

    2011-01-01

    Atrophic gastritis, is the main consequence of long-standing Helicobacter pylori infection, and is linked to the development of gastric cancer. The severity of atrophic gastritis is related to the lifetime risk of gastric cancer development, especially in terms of its degree and extent of mucosal damage. Therefore, it is important for clinicians to assess the severity of atrophic gastritis, interfere with the disease progress, and reverse gastric mucosal atrophy. In the article, we demonstrated some methods (conventional endoscopy, modern endoscopic technology and noninvasive methods) that may help assess the severity of atrophic gastritis and select the reasonable treatment protocols.

  1. Related Chronic Atrophic Gastritis with Megaloblastic Anemia%慢性萎缩性胃炎与巨幼细胞贫血的相关性

    Institute of Scientific and Technical Information of China (English)

    王义霞; 黄燕; 兰巧云

    2015-01-01

    目的:探讨慢性萎缩性胃炎与巨幼细胞贫血的相关性,为临床诊治提供参考。方法回顾分析自2012年10月-2014年10月期间该院收治的120例慢性萎缩性胃炎患者的临床资料。根据患者是否伴发巨幼细胞贫血,将其分为观察组(n=67)和对照组(n=53)。实验室检查患者叶酸(FA)和维生素B12的水平,胃镜检查时取胃黏膜组织作快速尿素酶试验检查幽门螺旋杆菌(Helicobacter pylori,Hp)。结果经胃镜+病理检查,发现观察组患者的维生素B12、叶酸水平均低于对照组,组间差异有统计学意义(P<0.05)。观察组Hp感染率为67.16%,对照组Hp感染率为69.81%;Hp阳性患者的维生素B12水平及叶酸水平均显著低于Hp阴性患者,差异具有统计学意义(P<0.05)。结论Hp阳性患者的血清维生素B12和叶酸水平显著低于Hp阴性患者,慢性萎缩性胃炎与巨幼细胞贫血有相关性,慢性萎缩性胃炎可诱发巨幼细胞贫血,巨幼细胞贫血能加剧慢性萎缩性胃炎的病情。%Objective To investigate the relationship between chronic atrophic gastritis and megaloblastic anemia as a reference for clinical staff. Retrospective analysis of 120 case of chronic atrophic gastritis in our hospital , which happened from October 2012 to October 2012. Methods 120 cases of patients were divided into two groups,observation group and control group, depend-ing on whether or not the patients suffering megaloblastic anemia. To determine the level of folic acid (FA) and the level vitamin B12 of all patients. To got tissue of gastric mucosa In the time of stomachoscopy, and then determined the status of Helicobacter py-lori (Hp) by rapid urease test. Results The level of FA and Vitamin B12 of observation group patients were lower than control group patients, showing significant difference (P<0.05). Observation group's Hp infection rate was 67.16%and control groups's Hp in-fection rate was 69

  2. The Prevalence of Helicobacter pylori Infection Decreases with Older Age in Atrophic Gastritis

    Directory of Open Access Journals (Sweden)

    Shaohua Chen

    2013-01-01

    Full Text Available The clinical pathological characteristics of 3969 adult patients with chronic atrophic gastritis were retrospectively studied. The positivity of intestinal metaplasia and dysplasia in atrophic gastric specimens increased with age; however, H. pylori positivity and inflammatory activity decreased significantly with increased age. H. pylori infection was present in 21.01% of chronic atrophic gastritis patients, and 92.33% of the subjects with H. pylori infection were found to have simultaneous inflammatory activity. The intestinal metaplasia and dysplasia positivity markedly increased as the degree of gastric atrophy increased. In conclusion, the incidence of H. pylori infection decreased with age and correlated significantly with inflammatory activity in atrophic gastritis patients. The intestinal metaplasia and dysplasia positivity notably increased as the degree of gastric atrophy increased. Large population-based prospective studies are needed to better understand the progression of CAG.

  3. Inflammatory cytokine gene polymorphisms increase the risk of atrophic gastritis and intestinal metaplasia

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    AIM: To investigate the effects of interleukin-8 (IL-8 ), macrophage migration inhibitory factor (MIF ) gene polymorphisms, Helicobacter pylori (H. pylori ) infection, on the risk of developing severe chronic atrophic gastritis (SCAG) and intestinal metaplasia (IM). METHODS: A total of 372 cases were selected from a cohort study in Linqu County, a high risk area for gastric cancer (GC) in northern China. To obtain a sufficient group size, patients with normal or superficial gastritis were included. Based on...

  4. Chronic gastritis - an update.

    Science.gov (United States)

    Varbanova, Mariya; Frauenschläger, Katrin; Malfertheiner, Peter

    2014-12-01

    Helicobacter pylori is the main aetiologic factor for chronic gastritis worldwide. The degree of inflammation and the evolution of this form of chronic gastritis can vary largely depending on bacterial virulence factors, host susceptibility factors and environmental conditions. Autoimmune gastritis is another cause of chronic inflammation in the stomach, which can occur in all age groups. This disease presents typically with vitamin B12 deficiency and pernicious anaemia. The presence of anti-parietal cell antibodies is highly specific for the diagnosis. The role of H. pylori as a trigger for autoimmune gastritis remains uncertain. Other rare conditions for chronic gastritis are chronic inflammatory conditions such as Crohn's disease or on the background of lymphocytic or collagenous gastroenteropathies. PMID:25439069

  5. Influence of H pylori on plasma ghrelin in patients without atrophic gastritis

    Institute of Scientific and Technical Information of China (English)

    Mehmet Cindoruk; Ilhan Yetkin; Serpil Muge Deger; Tarkan Karakan; Erdal Kan; Selahattin Unal

    2007-01-01

    AIM: To determine the association between H pylori infection and serum ghrelin levels in patients without atrophic gastritis.METHODS: Fifty consecutive patients (24 males and 26 females) with either H pylori-positive gastritis (n = 34) or H pylori-negative gastritis (n = 16) with normal gastric acid secretion determined by 24-h pHmetry and without atrophic gastritis in histopathology were enrolled in this study. Thirty-four H pylori-infected patients were treated with triple therapy consisting of a daily regimen of 30 mg lansoprazole bid, 1 g amoxicillin bid and 500 mg clarithromycin bid for 14 d, followed by an additional 4 wk of 30 mg lansoprazol treatment. H pylori infection was eradicated in 23 of 34 (67.6%) patients. H pylori-positive patients were given eradication therapy. Gastric acidity was determined via intragastric pH catethers. Serum ghrelin was measured by radioimmunoassay (RIA).RESULTS: There was no significant difference in plasma ghrelin levels between H pylori -positive and H pylori-negative groups (81.10 ± 162.66 ng/L vs 76.51 ± 122.94 ng/L). In addition, there was no significant difference in plasma ghrelin levels and gastric acidity levels measured before and 3 mo after the eradication therapy.CONCLUSION: H pylori infection does not influence ghrelin secretion in patients with chronic gastritis without atrophic gastritis.

  6. Serum Prohepcidin Levels Are Lower in Patients with Atrophic Gastritis

    Directory of Open Access Journals (Sweden)

    Hyung-Keun Kim

    2013-01-01

    Full Text Available Background/Aim. Hepcidin, an iron regulatory hormone, is increased in response to inflammation and some infections. We investigated the relationships among serum prohepcidin, iron status, Helicobacter pylori infection status, and the presence of gastric mucosal atrophy. Methods. Seventy subjects undergoing esophagogastroduodenoscopy underwent multiple gastric biopsies, and the possibility of H. pylori infection and the degree of endoscopic and histologic gastritis were investigated. In all subjects, serum prohepcidin and iron parameters were evaluated. Results. No correlations were observed between serum prohepcidin levels and the other markers of anemia, such as hemoglobin, serum iron, ferritin, and total iron binding capacity. Serum prohepcidin levels were not significantly different between the H. pylori-positive group and the H. pylori-negative group. Serum prohepcidin levels in atrophic gastritis patients were significantly lower than those in subjects without atrophic gastritis irrespective of H. pylori infection. Conclusion. Serum prohepcidin levels were not altered by H. pylori infection. Serum prohepcidin levels decrease in patients with atrophic gastritis, irrespective of H. pylori infection. It suggests that hepcidin may decrease due to gastric atrophy, a condition that causes a loss of hepcidin-producing parietal cells. Further investigations with a larger number of patients are necessary to substantiate this point.

  7. Netazepide, a gastrin receptor antagonist, normalises tumour biomarkers and causes regression of type 1 gastric neuroendocrine tumours in a nonrandomised trial of patients with chronic atrophic gastritis.

    Directory of Open Access Journals (Sweden)

    Andrew R Moore

    Full Text Available INTRODUCTION: Autoimmune chronic atrophic gastritis (CAG causes hypochlorhydria and hypergastrinaemia, which can lead to enterochromaffin-like (ECL cell hyperplasia and gastric neuroendocrine tumours (type 1 gastric NETs. Most behave indolently, but some larger tumours metastasise. Antrectomy, which removes the source of the hypergastrinaemia, usually causes tumour regression. Non-clinical and healthy-subject studies have shown that netazepide (YF476 is a potent, highly selective and orally-active gastrin/CCK-2 receptor antagonist. Also, it is effective in animal models of ECL-cell tumours induced by hypergastrinaemia. AIM: To assess the effect of netazepide on tumour biomarkers, number and size in patients with type I gastric NETs. METHODS: We studied 8 patients with multiple tumours and raised circulating gastrin and chromogranin A (CgA concentrations in an open trial of oral netazepide for 12 weeks, with follow-up 12 weeks later. At 0, 6, 12 and 24 weeks, we carried out gastroscopy, counted and measured tumours, and took biopsies to assess abundances of several ECL-cell constituents. At 0, 3, 6, 9, 12 and 24 weeks, we measured circulating gastrin and CgA and assessed safety and tolerability. RESULTS: Netazepide was safe and well tolerated. Abundances of CgA (p<0.05, histidine decarboxylase (p<0.05 and matrix metalloproteinase-7(p<0.10 were reduced at 6 and 12 weeks, but were raised again at follow-up. Likewise, plasma CgA was reduced at 3 weeks (p<0.01, remained so until 12 weeks, but was raised again at follow-up. Tumours were fewer and the size of the largest one was smaller (p<0.05 at 12 weeks, and remained so at follow-up. Serum gastrin was unaffected. CONCLUSION: The reduction in abundances, plasma CgA, and tumour number and size by netazepide show that type 1 NETs are gastrin-dependent tumours. Failure of netazepide to increase serum gastrin further is consistent with achlorhydria. Netazepide is a potential new treatment for type 1 NETs

  8. 慢性萎缩性胃炎的动物模型研究%Establishment of animal chronic atrophic gastritis model

    Institute of Scientific and Technical Information of China (English)

    冯秀雪; 令狐恩强

    2012-01-01

    Objective To establish an stable experimental model of chronic atrophic gastritis(CAG) in rats and investigate the effect on the liver preliminarily by stimulating rat gastric mucosa with multiple factors. Methods Rats were randomly divided into model group and normal control group. Rat in model group had free access to 0.1% ammonia water and drank a mixture of 2% sodium salicylate and 30% alcohol for the first 10 weeks followed by 20mmol/L sodium deoxycholate for the next 12 weeks, while those in normal group had free access to drinking water for 22 weeks. Results The general condition was worse, the body weight gain was slower, the atrophy of glands was more significant, the mucosa was thinner, the muscular layer of mucosa was thicker, and the infiltration of inflammatory cells was severer in model group than in normal control group. No intestinal metaplasia and dysplasia, and no obvious abnormality of liver pathology were observed in two groups. Conclusion A CAG model is successfully established by stimulating gastric mucosa with multiple factors, with no obvious effect on liver pathology.%目的 通过多因素刺激大鼠胃黏膜,建立稳定的慢性萎缩性胃炎的大鼠模型并初步探讨造模方法对于肝脏的影响.方法 将大鼠随机分为模型组与正常组,模型组自由饮用0.1% 氨水,前10 周用2%水杨酸钠和30%酒精混合溶液灌胃,后12周用20mmol/L 去氧胆酸钠溶液灌胃;正常对照组正常饮水,用饮用水灌胃22 周.结果 与正常组比较,模型组大鼠一般情况较差,体重增加缓慢,胃窦腺体萎缩明显,黏膜层变薄且黏膜肌层相对增厚,炎性细胞浸润明显;两组均未见到肠化生及异型增生等现象.两组肝脏病理均无明显异常.结论 利用多因素刺激成功建立了萎缩性胃炎模型,且此模型对肝脏病理影响不明显.

  9. Elevated risk of recurrent colorectal neoplasia with Helicobacter pylori-associated chronic atrophic gastritis: A follow-up study of patients with endoscopically resected colorectal neoplasia

    OpenAIRE

    Inoue, Izumi; Kato, Jun; Yoshimura, Noriko; Maeda, Yoshimasa; Moribata, Kosaku; Shingaki, Naoki; Deguchi, Hisanobu; Enomoto, Shotaro; Maekita, Takao; UEDA, KAZUKI; Iguchi, Mikitaka; Tamai, Hideyuki; FUJISHIRO, MITSUHIRO; Yamamichi, Nobutake; Takeshita, Tatsuya

    2012-01-01

    In a previous population-based case-control study, we demonstrated an elevated risk of colorectal neoplasia with Helicobacter pylori (H. pylori) infection. The present study investigated the effects of H. pylori-associated chronic gastritis on the development of colorectal neoplasia by analyzing the recurrence of colorectal neoplasia subsequent to endoscopic resection. Ninety-nine patients who had undergone endoscopic resection of colorectal neoplasia were monitored under colonoscopy, and the...

  10. Effect of Amoxicillin Combined With Bismuth Pectin in the Treatment of Chronic Atrophic Gastritis%阿莫西林配合果胶铋治疗慢性萎缩性胃炎的效果探讨

    Institute of Scientific and Technical Information of China (English)

    苏同森; 刘文翠; 王均成

    2016-01-01

    Objective To observe and analyze the clinical effect of amoxicilin and bismuth pectin bismuth in treatment of chronic atrophic gastritis. Methods According to the principle of voluntary patients,94 cases of chronic atrophic gastritis patients composition study group(47 cases)and control group(47 cases),the former treated with amoxicilin and bismuth pectin,the latter to be clarithromycin and coloidal bismuth pectin treatment,and compared between the two groups of patients with clinical curative effect observation.ResultsThe effective rate of the study group(93.6%)was significantly higher than that in the control group(76.6%),the difference was statisticaly significant(P<0.05,χ2=8.115),recurrence rate of the study group(6.4%) was lower than that of the control group(12.8%),the difference was statisticaly significant(P<0.05,χ2=7.361).Conclusion The effect of amoxicilin combined with bismuth pectin bismuth on chronic atrophic gastritis is significant,and the recurrence rate is low.%目的:观察与分析阿莫西林联合果胶铋在慢性萎缩性胃炎疾病治疗中的临床运用效果。方法依据患者自愿原则,将94例慢性萎缩性胃炎患者成分研究组(47例)与对照组(47例),前者予以阿莫西林+果胶铋治疗,后者予以克拉霉素+果胶铋治疗;观察与比较两组患者的临床疗效。结果研究组患者治疗后的有效率(93.6%)比对照组患者(76.6%)高,差异有统计学意义(P<0.05,χ2=8.115);研究组患者复发率(6.4%)低于对照组(12.8%),差异有统计学意义(P<0.05,χ2=7.361)。结论采取阿莫西林联合果胶铋治疗慢性萎缩性胃炎,效果显著,且复发率低。

  11. 阿莫西林配合果胶铋治疗慢性萎缩性胃炎的效果探讨%Effect of Amoxicillin Combined With Bismuth Pectin in the Treatment of Chronic Atrophic Gastritis

    Institute of Scientific and Technical Information of China (English)

    苏同森; 刘文翠; 王均成

    2016-01-01

    目的:观察与分析阿莫西林联合果胶铋在慢性萎缩性胃炎疾病治疗中的临床运用效果。方法依据患者自愿原则,将94例慢性萎缩性胃炎患者成分研究组(47例)与对照组(47例),前者予以阿莫西林+果胶铋治疗,后者予以克拉霉素+果胶铋治疗;观察与比较两组患者的临床疗效。结果研究组患者治疗后的有效率(93.6%)比对照组患者(76.6%)高,差异有统计学意义(P<0.05,χ2=8.115);研究组患者复发率(6.4%)低于对照组(12.8%),差异有统计学意义(P<0.05,χ2=7.361)。结论采取阿莫西林联合果胶铋治疗慢性萎缩性胃炎,效果显著,且复发率低。%Objective To observe and analyze the clinical effect of amoxicilin and bismuth pectin bismuth in treatment of chronic atrophic gastritis. Methods According to the principle of voluntary patients,94 cases of chronic atrophic gastritis patients composition study group(47 cases)and control group(47 cases),the former treated with amoxicilin and bismuth pectin,the latter to be clarithromycin and coloidal bismuth pectin treatment,and compared between the two groups of patients with clinical curative effect observation.ResultsThe effective rate of the study group(93.6%)was significantly higher than that in the control group(76.6%),the difference was statisticaly significant(P<0.05,χ2=8.115),recurrence rate of the study group(6.4%) was lower than that of the control group(12.8%),the difference was statisticaly significant(P<0.05,χ2=7.361).Conclusion The effect of amoxicilin combined with bismuth pectin bismuth on chronic atrophic gastritis is significant,and the recurrence rate is low.

  12. [Collagenous colitis, IgA deficiency, Basedow's disease and atrophic gastritis].

    Science.gov (United States)

    Pariente, E A; Chaumette, M T; Maître, F; Delchier, J C; Soulé, J C; Bader, J P

    1985-10-01

    In a 37-year-old woman with chronic watery diarrhea of three years duration, the diagnostic of collagenous colitis was established by optical and ultrastructural examination of rectal and colonic biopsies. No other cause of diarrhea could be found. Moreover, this patient had also selective IgA deficiency, Grave's disease and chronic atrophic gastritis of auto-immune type. Sequential treatments with loperamide, cholestyramine and antibiotics did not modified diarrhea which improved with salazosulfapyridine and betamethasone enemas. These observations suggest that collagenous colitis might be a part of the spectrum of enteropathies associated with immunoglobulin deficiencies. PMID:3840757

  13. Endoscopic Diagnosis of Chronic Atrophic Gastritis:An Analysis of Accuracy%胃镜下慢性萎缩性胃炎诊断准确性研究

    Institute of Scientific and Technical Information of China (English)

    王蕾; 朱薇; 陈楚弟; 张亚历

    2012-01-01

    目的 系统评价胃镜下慢性萎缩性胃炎诊断的临床价值.方法 以我院内镜资料为第一部分,以Meta分析方法全面收集2000年以来我国公开发表的关于胃镜下慢性萎缩性胃炎诊断准确性分析的文献所提供数据为第二部分,全面收集慢性萎缩性胃炎内镜诊断准确性资料,进行Meta分析.结果 Meta分析提示各试验间具有明显的异质性,合并敏感度(SEN)80.3%[95%CI(0.790,0.816)],合并特异度(SPE)94.4%[95%CI(0.938,0.948)],阳性似然比(LR+)7.448[95%CI(2.703,20.522)],阴性似然比(LR-)0.377[95%CI(0.210,0.676)],SROC曲线下面积(AUC)=0.806.结论 由于诊断标准、操作人员技术等方面的原因,Meta分析提示各地文献报道数据具有明显的异质性,胃镜下慢性萎缩性胃炎的诊断具有较低的合并敏感度和较高的合并特异度,通过统一的诊断标准与规范化培训,敏感度与特异度尚有一定的提升空间,就目前而言,对于不适宜或不能接受活检的患者,胃镜下萎缩性胃炎诊断具有较高的临床价值.%Objective To conduct a systematic review of clinical value for endoscopic diagnosis of chronic atrophic gastritis. Methods We selected both of the clinical dates in our hospital and the published dates in Chinese journals from 2000 to 2011, which evaluated the accuracy of endoscopic diagnosis of chronic atrophic gastritis, and then performed systematic review and Meta - analysis. Results Meta analysis revealed a remarkable heterogeneity among all the trials. The pooled sensitivity for endoscopic diagnosis was 80. 3% [ 95% CI ( 0. 790, 0. 816 ) ], and the pooled specificity was 94. 4% [ 95% CI ( 0. 938, 0. 948 ) ]. The positive likelihood ratio ( LR+ ) was 7. 448 [ 95% CI ( 2. 703 , 20. 522 )], and the negative likelihood ratio ( LR- ) was 0. 377 [ 95% CI (0. 210, 0. 676 ) ]. The SROC area under the curve ( AUC ) was 0. 806. Conclusion Because of different diagnostic criteria and operators' skills there is a

  14. Increased Production of Lysozyme Associated with Bacterial Proliferation in Barrett's Esophagitis, Chronic Gastritis, Gluten-induced Atrophic Duodenitis (Celiac Disease), Lymphocytic Colitis, Collagenous Colitis, Ulcerative Colitis and Crohn's Colitis.

    Science.gov (United States)

    Rubio, Carlos A

    2015-12-01

    The mucosa of the esophagus, the stomach, the small intestine, the large intestine and rectum are unremittingly challenged by adverse micro-environmental factors, such as ingested pathogenic and non-pathogenic bacteria, and harsh secretions with digestive properties with disparate pH, as well as bacteria and secretions from upstream GI organs. Despite the apparently inauspicious mixture of secretions and bacteria, the normal GI mucosa retains a healthy state of cell renewal. To by-pass the tough microenvironment, the epithelia of the GI react by speeding-up cell exfoliation, by increasing peristalsis, eliminating bacteria through secretion of plasma cell-immunoglobulins and by increasing production of natural antibacterial enzymes (lysozyme) and host defense peptides (defensin-5). Lysozyme was recently found up-regulated in Barrett's esophagitis, in chronic gastritis, in gluten-induced atrophic duodenitis (celiac disease), in collagenous colitis, in lymphocytic colitis and in Crohn's colitis. This up-regulation is a response directed towards the special types of bacteria thriving in the microenvironment in each of the aforementioned clinical inflammatory maladies. The purpose of that up-regulation is to protect the mucosa affected by the ongoing chronic inflammation. Bacterial antibiotic resistance continues to exhaust our supply of effective antibiotics. The future challenge is how to solve the increasing menace of bacterial resistance to anti-bacterial drugs. Further research on natural anti-bacterial enzymes such as lysozyme, appears mandatory. PMID:26637845

  15. Clinical significance of expression of livin and cyclin D1 in chronic atrophic gastritis with intestinal metaplasia%Livin和CyclinD1在慢性萎缩性胃炎伴肠化黏膜中的表达及意义

    Institute of Scientific and Technical Information of China (English)

    陈吉; 崔宏; 高美丽; 崔琴

    2012-01-01

    目的:探讨凋亡抑制蛋白Livin和细胞周期蛋白D1(CyclinDI)在慢性萎缩性胃炎(chronicatrophic gastritis,CAG)伴肠化癌变过程中的表达及其相关性.方法:应用免疫组织化学染色S-P法检测Livin和CyclinD1在30例慢性浅表性胃炎(chronicsuperficial gastritis,CSG)、35例CAG非肠化、35例CAG伴肠化、30例胃癌组织中的表达,并同时研究二者在CAG伴肠化癌变中表达的相关性.结果:在CSG、CAG非肠化、CAG伴肠化、胃癌中Livin、CyclinD1的阳性表达率分别为:0%、10%; 28.57%、14.29%; 45.71%、37.14%; 66.67%、53.33%,二者在CAG(非肠化)和CSG对比均有统计学意义(P<0.05);CAG(伴肠化)与CAG(非肠化)相比,CyclinD1的阳性表达率有统计学意义(P<0.05); Livin和CyclinD1在CAG伴肠化、胃癌组织中表达呈正相关.结论:Livin、CyclinD1蛋白在CAG(伴肠化)和胃癌组织中表达呈上调状态,且CAG(伴肠化)和胃癌组织间无显著差异,二者表达一致,提示CAG(伴肠化)已具有癌变的分子生物学特征.二者在胃癌的发生、发展中起协同作用,对其进行联合检测将有助于胃癌的早期诊断.%AIM: To investigate the expression of livin and cyclinDl in chronic atrophic gastritis with intestinal metaplasia.METHODS: Immunohistochemistry was used to examine the expression of livin and cyclin Dl in 30 cases of chronic superficial gastritis, 35 cases of atrophic gastritis without intestinal metaplasia, 35 cases of atrophic gastritis with intestinal metaplasia, and 30 cases of gastric carcinoma. We also explored the correlation between livin and cyclin Dl expression in chronic atrophic gastritis and gastric carcinoma.RESULTS: The positive rates of livin expression in the specimens of chronic superficial gastritis,atrophic gastritis without intestinal metaplasia, atrophic gastritis with intestinal metaplasia, and gastric carcinoma were 0%, 28.57%, 45.71% and 66.67%, respectively, and the corresponding rates for

  16. Effects of Helicobacter pylori eradication on atrophic gastritis and intestinal metaplasia: A 3-year follow-up study

    Institute of Scientific and Technical Information of China (English)

    Bin Lu; Ming-Tao Chen; Yi-Hong Fan; Yan Liu; Li-Na Meng

    2005-01-01

    AIM: To investigate the effect of H pylori eradication on atrophic gastritis and intestinal metaplasia (IM).METHODS: Two hundred and fifty-nine patients with atrophic gastritis in the antrum were included in the study, 154 patients were selected for H pylori eradication therapy and the remaining 105 patients served as untreated group. Gastroscopy and biopsies were performed both at the beginning and at the end of a 3-year follow-up study. Gastritis was graded according to the updated Sydney system.RESULTS: One hundred and seventy-nine patients completed the follow-up, 92 of them received H pylori eradication therapy and the remaining 87 H pyloriinfected patients were in the untreated group. Chronic gastritis, active gastritis and the grade of atrophy significantly decreased in H pylori eradication group (P<0.01). However, the grade of IM increased in H pylori -infected group (P<0.05).CONCLUSION: H pylori eradication may improve gastric mucosal inflammation, atrophy and prevent the progression of IM.

  17. Systematic Review on Treatment of Chronic Atrophic Gastritis by Reinforcing qi, Promoting Blood Circulation and Replenishing Yin%益气活血养阴法治疗慢性萎缩性胃炎的系统评价

    Institute of Scientific and Technical Information of China (English)

    刘婷; 刘福生; 张寅; 杜娜; 苏泽琦; 丁霞

    2015-01-01

    Objective:To systematically evaluate the efficacy of reinforcing qi ,promoting blood circulation and replenishing yin on treating chronic atrophic gastritis. Methods:Relevant Chinese and English literature of randomized clinical trials(RCTs) were reviewed via database. Trials were adopted if the Jadad scale score was 1 or more. Statistical heterogeneity between trials was evaluated by Revman 5.2. Heterogeneity of the in-cluded articles was tested to select proper effect models for calculation. Publication bias was investigated through visual inspection of funnel plots and Egger ’s regression model. Results:Nine RCTs including 846 patients were analyzed. The quality of RCTs are generally low. Compared with western medical treatment , reinforcing qi,promoting blood circulation and replenishing yin was better in improving the total effective rate of chronic gastritis. OR=4.57,95%CI (3.09~6.77). The difference was statistically significant (P<0.00001). Conclusion:Reinforcing qi,promoting blood circulation and replenishing yin may be superior to western medicines in improving total effective rate of patients with chronic atrophic gastritis. But more high quality research is needed to increase the strength of the evidence.%目的:系统评价中医益气活血养阴法治疗慢性萎缩性胃炎的疗效。方法:通过数据库检索中英文随机对照试验(RCT)文献,将Jadad积分≥1分的文章纳入研究,并提取纳入研究的特征信息。采用Revman 5.2软件进行Meta-分析,检验异质性,并根据异质性结果选择相应的效应模型,最后绘制漏斗图及Egger回归方程评定有无发表偏倚。结果:最终有9项RCT,共846例患者入选,文献质量普遍较低。益气活血养阴法治疗慢性萎缩性胃炎的总体疗效优于单纯的西医治疗,其汇总OR=4.57,95%CI(3.09~6.77),差异均具有统计学意义(P<0.00001)。结论:益气活血养阴法治疗慢性萎缩

  18. The Treatment of Chronic Atrophic Gastritis with Dysplasia by Chinese Medicine:A Systematic Review%中医药治疗慢性萎缩性胃炎伴异型增生疗效的系统评价

    Institute of Scientific and Technical Information of China (English)

    魏霞; 钦丹萍

    2013-01-01

    [Objective] Through a meta-analysis to compare the effectiveness and safety of traditional Chinese medicine and western medicine in the treat-ment of chronic atrophic gastritis(CAG) with dysplasia . [Methods] Randomized clinical trials(RCTs) which compared traditional Chinese medicine and western medicine for chronic atrophic gastritis with dysplasia in PubMed, Cochrane library, WanFang and CNKI were searched. The patients which were analyzed were divided into two groups: western medicine and traditional Chinese medicine.Statistical heterogeneity between trials was evaluated by RevMan5.0. Heterogeneity of the included articles was tested and used to select proper effective model for calculation.Publication bias was investigated through visual inspection of funnel plots and Egger's regression model.[Results] 6 RCTs including 632 patients were analyzed. The total odd ratios(OR) of clinical symptoms,gastroscope symptoms,pathological symptoms by traditional Chinese medicine were higher than western medicine, the OR values were 3.40(95%CI:2.18~5.31,P<0.01),4.14(95%CI:2.37~7.20,P<0.01),2.94(95%CI:1.77~4.90,P<0.01),3.71(95%CI:2.29~6.02,P<0.01),4.41(95%CI:2.75~7.07,P<0.01),5.21 (95%CI:3.65~7.43,P<0.01). Inspection of the funnel plots for al outcome measures did not reveal evidence of publication bias( P=0.81, 0.41, 0.29, 0.88, 0.44, 0.82, respectively).[Conclusions] The treatment of chronic atrophic gastritis with dysplasia by traditional Chinese medicine can improve the excel ent response rate, overal response rate of clinical symptoms,gastroscope symptoms,pathological symptoms better than its purely western medicine treatment efficacy.%  [目的]分析比较中医药治疗与西医治疗慢性萎缩性胃炎(chronic atrophic gastritis,CAG)伴异型增生的疗效和安全性。[方法]检索PubMed、Cochrane图书馆、万方和中国期刊网中的随机对照试验(randomized control ed trial,RCT)文献,根据纳入标准将论文纳入研究并提取纳

  19. Association of autoimmune type atrophic corpus gastritis with Helicobacter pylori infection

    Institute of Scientific and Technical Information of China (English)

    Lea; Irene; Veijola; Aino; Mirjam; Oksanen; Pentti; Ilmari; Sipponen; Hilpi; Iris; Kaarina; Rautelin

    2010-01-01

    AIM:To study the association between Helicobacter pylori(H.pylori)infection and autoimmune type atrophic gastritis. METHODS:Twenty-three patients with different grades of atrophic gastritis were analysed using enzyme immunoassay-based serology,immunoblot-based serology,and histology to reveal a past or a present H.pylori infection.In addition,serum markers for gastric atrophy(pepsinogenⅠ,pepsinogenⅠ/Ⅱand gastrin)and autoimmunity[parietal cell antibodies(PCA), and intrinsic factor(IF),antibodies]were determi...

  20. HOGG1 polymorphism in atrophic gastritis and gastric cancer after Helicobacter pylori eradication

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    AIM:To investigate the association between Ser326Cys human oxoguanine glycosylase 1(hOGG1) polymorphism and atrophic gastritis and gastric cancer after Helicobacter pylori(H.pylori) eradication.METHODS:A total of 488 subjects(73 patients with gastric cancer,160 with atrophic gastritis after H.pylori eradication and 255 controls) were prospectively collected.Polymerase chain reaction-restriction fragment length polymorphism analysis was performed to distinguish hOGG1 Ser326Cys polymorphism.Statistical analys...

  1. Protective effects of heat shock protein70 induced by geranyl-geranylacetone in atrophic gastritis in rats

    Institute of Scientific and Technical Information of China (English)

    Wei-li LIU; Shu-jie CHEN; Yan CHEN; Lei-min SUN; Wei ZHANG; Ya-min ZENG; Tian-hua ZHOU; Jian-min SI

    2007-01-01

    Aim: To investigate the effect of geranylgeranylacetone (GGA) on the progres-sion of atrophic gastritis in rats and its potential mechanism. Methods: Atrophic gastritis was induced in Sprague-Dawley rats with 0.1% ammonia solution, 60% ethanol, and 20 mmol/L deoxycholic acid for 24 weeks. Accompanied by the induction of atrophic gastritis, 200 mg/kg GGA was administered by oral gavage for 8 weeks (weeks 17-24). The histological changes in gastric mucosa were quantitated by the index of inflammation, the gastric mucosal thickness, and the amount of glands of 1 mm horizontal length in antrum. Endogenous heat shock protein (HSP)70 levels and distribution were determined by immunoblotting and immunohistochemistry in gastric mucosa. Results: GGA alleviated the pathologi-cal progression of atrophic gastritis with inflammation relief (inflammation index: 1.40 in the GGA group and 1.65 in the atrophic gastritis group) and glandular restoration (rnucosal thickness and quantity of glands: 194.3 μm and 38.7 mm in the GGA group; 123.3 μm and 32.7 mm in the atrophic gastritis group; P<0.05). GGA significantly induced HSP70 synthesis (P<0.05). Moreover, quercetin, an inhibitor of HSP70 expression, aggravated the infiltration of inflammatory cells and glandular loss in the antrum. Conclusion: GGA prevented the progression of atrophic gastritis in rats via the induction of HSP70 expression.

  2. Comparative examinations of serum pepsinogen I, II and gastric area using computed radiography in the atrophic gastritis

    Energy Technology Data Exchange (ETDEWEB)

    Tatsu, Yoshimitsu; Ogura, Yasuharu; Yamazaki, Kouichi [Osaka Medical Coll., Takatsuki (Japan)] [and others

    1995-11-01

    The relationship between serum PG I, PG II levels and extent of atrophic gastritis was examined. The subjects were 64 patients (male: 32, female: 32, 51.9 years old on average) with established diagnosis of either atrophic gastritis or normal. In the X-ray gastric examination, Fuji Computed Radiography (FCR) was used to obtain clear-cut images of the gastric area. Concerning the serum PG I level, patients in the group with atrophic gastritis showed lower levels than those of the people in the group with no atrophic change, but the variation was wide, and no definite tendency was seen in the relationship between the atrophic change and the serum PG I levels. Concerning the serum PG II level, as the atrophic change progresses, the serum PG II level tended to increase gradually. A significant reduction in the PG I/II ratio was seen in the group with atrophic changes (p<0.01) in comparison with the group with no atrophic changes, and the PG I/II value tended to decrease. In conclusion, as a relationship between the atrophic change and the serum PG levels had a wide variation, we considered it to be difficult to understand the presence and extent of the atrophic gastritis by measuring serum PG levels. (author).

  3. Lack of specific association between gastric autoimmunity hallmarks and clinical presentations of atrophic body gastritis

    Institute of Scientific and Technical Information of China (English)

    Bruno Annibale; Edith Lahner; Riccardo Negrini; Flavia Baccini; Cesare Bordi; Bruno Monarca; Gianfranco Delle Fave

    2005-01-01

    AIM: To investigate the possible relationships between gastric autoimmune phenomena and clinical presentations of this disorder, in consecutive atrophic body gastritis patients.METHODS: A total of 140 atrophic body gastritis patients,diagnosed as consecutive outpatients presenting with macrocytic or iron deficiency anemia, or longstanding dyspepsia underwent gastroscopy with antral and body biopsies, assay of intrinsic factor, parietal cells and Helicobacter pylori(H pylori) antibodies. Gastritis was assessed according to Sydney System.RESULTS: Parietal cell antibodies were equally distributed in all clinical presentations, whereas the positivity of intrinsic factor antibodies (49/140, 35%) was significantly higher in pernicious anemia patients (49.2%) than in iron deficiency (21.1%) and dyspeptic patients (27.8%). No specific pattern of autoantibodies was related to the clinical presentations of atrophic body gastritis. A positive correlation was obtained between the body atrophy score and the intrinsic factor antibody levels (r = 0.2216,P = 0.0085). Associated autoimmune diseases were present in 25/140 (17.9%) patients, but the prevalence of autoimmune diseases was comparable, irrespective of the clinical presentations.CONCLUSION: The so-called hallmarks of gastric autoimmunity, particularly in intrinsic factor antibody cannot be usefully employed in defining an autoimmune pattern in the clinical presentations of ABG.

  4. ESTABLISHMENT OF MODIFIED RAT MODEL WITH CHRONIC ATROPHIC GASTRITIS INFECTED BY HELICOBACTER PYLORI%改良式Hp感染萎缩性胃炎大鼠模型的建立

    Institute of Scientific and Technical Information of China (English)

    唐旭东; 张翠萍; 张琪; 赵坤; 孙向红; 田字彬

    2012-01-01

    目的 建立较理想的幽门螺杆菌(Hp)感染慢性萎缩性胃炎(CAG)大鼠模型.方法 雄性Wistar大鼠60只,随机分为Hp感染及水杨酸钠乙醇灌胃组(模型组)、正常对照组(A组)、单纯Hp感染组(B组)、单纯水杨酸钠乙醇灌胃组(C组).采用灌胃接种Hp菌株(SSI)及20 g/L水杨酸钠与体积分数0.60的乙醇混合溶液方法建立Hp感染CAG模型,共14周.检测各组Hp定植情况,并对胃窦黏膜病理组织学各项指标进行评分.结果 模型组及B组胃窦黏膜均有Hp定植.模型组胃窦黏膜变薄,固有层腺体中度减少伴有中度慢性活动性炎症.模型组慢性炎症评分、活动性炎症评分及固有腺减少评分均明显高于A、B组(x2=47.632~48.276,q=6.514~11.191,P<0.01),而与C组比较,差异无显著性(P>0.05).结论 采用Hp感染大鼠及水杨酸钠与乙醇混合溶液灌胃的方法建立Hp感染CAG大鼠模型,其病因、病理变化与人类CAG病变相似,可作为研究Hp感染CAG发病机制及药物干预治疗CAG较合适的动物模型.%Objective To create a more ideal rat model of chronic atrophic gastritis 0. 05), Conclusion The causes of disease and pathological changes in rat models of CAG that created by Hp infection combined with mixed solution of sodium salicylate and ethanol are similar to that found in human subjects. This can be used as a suitable animal model in researching the mechanism of CAG due to Hp infection and drug therapy for this condition.

  5. The Efect of Helicobacter Pylori Eradication on Atrophic Gastritis and Intestinal metaplasia

    OpenAIRE

    Guldem Kilciler

    2011-01-01

     Aim: The aim of this prospective study was to evaluate whether helicobacter pylori eradication could improve gastric atropy or intestinal metaplasia. Material and Method: Forty-two pylori infected patients were evaluated for the status of atrophic gastritis and intestinal metaplasia. Two biopsy specimens from antrum and two biopsy specimens from corpus were taken before and 6 months after the helicobacter pylori eradication therapy. Helicobacter pylori status was determined by C-urea br...

  6. The prediction vaule of pepsinogenⅠ combined with gastrin-17 in lesion location of chronic atrophic gastritis and the period of gastric cancer pro-gression%胃蛋白酶原Ⅰ联合胃泌素-17检测对慢性萎缩性胃炎发病部位及胃癌进展时期的预测价值

    Institute of Scientific and Technical Information of China (English)

    周海平

    2014-01-01

    目的:探讨胃蛋白酶原Ⅰ(PGⅠ)联合胃泌素-17(G-17)检测对慢性萎缩性胃炎发病部位及胃癌进展时期的预测价值。方法选择本院收治的慢性萎缩性胃炎患者33例、胃癌患者35例作为研究对象,进行PGⅠ、PGⅡ和G-17检测,比较并分析PGⅠ、PGⅡ及G-17水平的变化情况。结果慢性萎缩性胃炎组PGⅠ和G-17水平高于胃癌组,差异有统计学意义(P<0.05),胃窦部组的PGⅠ水平高于胃体部组和全胃弥漫组,差异有统计学意义(P<0.05),胃体部组的G-17水平高于全胃弥漫组和胃窦部组,差异有统计学意义(P<0.05),早期胃癌或原位癌的PGⅠ和G-17水平显著高于进展期胃癌,差异有统计学意义(P<0.05)。结论胃窦部发病为主的慢性萎缩性胃炎其G-17显著下降,胃体部或全胃病变者PGⅠ的下降更加明显,进展期胃癌者PGⅠ水平更低而G-17水平更高。%Objective To investigate the prediction vaule of pepsinogenⅠ combined with gastrin-17 in lesion location of chronic atrophic gastritis and the period of gastric cancer progression. Methods 33 cases with chronic atrophic gas-tritis and 35 cases in the different period of gastric cancer in our hospital were selected as research objects.All these participants were detected by pegsinogenⅠ,pegsinogenII and gastrin-17.The level of pegsinogenⅠ,pegsinogenII and gastrin-17 were compared and analyzed. Results The level of pepsinogens I and gastrin-17 in chronic atrophic gastri-tis group were higher than that in gastric cancer group,with statistical difference(P<0.05).Pepsinogen I level in the gas-tric antrum of chronic atrophic gastritis was higher than that in the gastric body and the total diffuse,with statistical dif-ference (P<0.05),the gastrin-17 level in the gastric body was higher than that in the total diffuse and in the gastric antrum,with statistical difference (P<0.05).Pepsinogen I and gastrin-17 lever of early gastric cancer and carcinoma

  7. Clinical study of compound alverine citrate in treating chronic non-atrophic gastritis%复方枸橼酸阿尔维林治疗慢性非萎缩性胃炎的效果研究

    Institute of Scientific and Technical Information of China (English)

    黄振鹏; 梁仲惠; 李锦丽; 叶家享

    2014-01-01

    目的 观察复方枸橼酸阿尔维林治疗慢性非萎缩性胃炎的效果和不良反应.方法 124例慢性非萎缩性胃炎患者完全随机分为观察组和对照组,各62例.观察组口服雷贝拉唑钠肠溶胶囊(10 mg/次,2次/d)、复方枸橼酸阿尔维林(1粒/次,3次/d),对照组口服雷贝拉唑(10 mg/次,2次/d)、枸橼酸莫沙必利(5 mg/次,3次/d),均用药2周.记录2组治疗前和治疗第2周末各症状评分和症状总积分,并参照各症状评分和症状总积分变化评价疗效.结果 治疗结束后第2周末,观察组各症状评分均较治疗前明显下降(P<0.05);观察组上腹疼痛、腹胀、嗳气症状评分明显低于对照组[(0.9±0.4)分比(1.6±0.5)分,(0.8±0.4)分比(2.3±0.7)分,(0.80 ±0.19)分比(1.13 ±0.44)分],组间差异有统计学意义(P<0.05),反酸、上腹不适症状积分的组间差异无统计学意义(均P>0.05);2组症状总积分均较治疗前下降,观察组治疗后症状总积分明显低于对照组[(4.7±1.2)分比(7.6±1.2)分](P<0.05).观察组上腹疼痛、腹胀、反酸、嗳气、上腹不适等各症状有效率和总有效率分别为91.7% (55/60)、94.8%(55/58)、90.3% (28/31)、91.1% (41/45)、89.8% (53/59)、95.0% (57/60),均高于对照组[82.8%(48/58)、74.1%(43/58)、77.4%(24/31)、72.2%(26/36)、83.0%(49/59)、91.5%(54/59)],差异有统计学意义(均P <0.05).2组患者不良反应发生率差异无统计学意义(P>0.05).结论 复方枸橼酸阿尔维林辅助治疗慢性非萎缩性胃炎,可较好缓解腹痛、消化不良等症状,总有效率较高,不良反应较低.%Objective To discuss the effect of compound alverine citrate treating chronic non-atropmc gastritis and related adverse reaction.Methods Totally 124 cases of chronic non-atrophic gastritis were divided into observation group and control group.Observation group received rabeprazole and compound alverine citrate; control group received rabeprazole and

  8. Can chronic gastritis cause an increase in fecal calprotectin concentrations?

    Institute of Scientific and Technical Information of China (English)

    Massimo; Montalto; Antonella; Gallo; Gianluca; Ianiro; Luca; Santoro; Ferruccio; D; Onofrio; Riccardo; Ricci; Giovanni; Cammarota; Marcello; Covino; Monica; Vastola; Antonio; Gasbarrini; Giovanni; Gasbarrini

    2010-01-01

    AIM:To evaluate fecal calprotectin concentrations(FCCs) in subjects with chronic gastritis and the correlation between FCCs and gastritis activity score.METHODS:FCCs were measured in 61 patients with histological diagnosis of gastritis and in 74 healthy volunteers.Histological grading of gastritis was performed according to the updated Sydney gastritis classification.Patients were subdivided into 2 groups according to the presence/absence of an active gastritis.Patients with chronic active gastritis were di...

  9. Accuracy of GastroPanel for the diagnosis of atrophic gastritis

    Science.gov (United States)

    Forné, Montserrat; Barrio, Jesus; De la Coba, Cristobal; González, Begoña; Rivera, Robin; Esteve, Maria; Fernandez-Bañares, Fernando; Madrigal, Beatriz; Gras-Miralles, Beatriz; Perez-Aisa, Angeles; Viver-Pi-Sunyer, Jose M.; Bory, Felipe; Rosinach, Merce; Loras, Carmen; Esteban, Carlos; Santolaria, Santos; Gomollon, Fernando; Valle, Julio; Gisbert, Javier P.

    2014-01-01

    Background It has been suggested that GastroPanel might be a useful tool for the diagnosis of chronic atrophic gastritis (CAG) measuring four biomarkers in blood: basal gastrin-17 (G17), pepsinogen I and II (PGI and PGII), and Helicobacter pylori antibodies. Aim To determine the accuracy of GastroPanel for the diagnosis of CAG. Methods This was a prospective, blinded, multicenter study that included dyspeptic patients. G17, PGI, and PGII were determined by enzyme immunoassays. Three antrum and two corpus biopsies were obtained for standard histological analysis and rapid urease test. Biopsies were analyzed by a single blinded expert pathologist. Results Ninety-one patients were included (77% women, mean age 44 years, 51% H. pylori positive, 17% with CAG). G17 was reduced in patients with antrum CAG (5.4 vs. 13.4 pmol/l; P<0.01) and increased in patients with corpus CAG (11 vs. 24 pmol/l; P<0.05), but its accuracy was only acceptable in the case of corpus localization [area under the receiver operating characteristic curve (AUC), 74%]; PGII difference was almost statistically significant only when testing for corpus atrophy (33 vs. 21 μg/l; P=0.05; AUC=72%). The PGI and PGI/PGII ratio showed no significant differences (AUCs were all unacceptably low). Helicobacter pylori antibody levels were higher in H. pylori-infected patients (251 vs. 109 EIU, P=0.01; AUC=70). The accuracy of GastroPanel for the diagnosis of CAG was as follows: sensitivity 50%; specificity 80%; positive 25% and negative 92% predictive values; and positive 2.4 and negative 0.6 likelihood ratios. Conclusion GastroPanel is not accurate enough for the diagnosis of CAG; thus, its systematic use in clinical practice cannot be recommended. PMID:25014624

  10. Curative Effect Evaluation of Banxia Xiexin Decoction on Chronic Atrophic Gastritis (Cold-Heat Complicated Syndrome)Based on the Calibration Biopsy Technique%基于定标活检技术评价半夏泻心汤对慢性萎缩性胃炎(寒热错杂证)的疗效

    Institute of Scientific and Technical Information of China (English)

    刘洁; 刘琳; 李慧臻

    2013-01-01

    目的:基于定标活检技术评价半夏泻心汤对慢性萎缩性胃炎(寒热错杂证)的疗效.方法:符合诊断标准的病例30例,随机分为治疗组(半夏泻心汤组)和对照组(胃复春组),3个月为1个疗程.观察治疗前后两组的临床症状,并在定标活检下观察胃镜下病理改变情况.结果:临床症状:两组在改善症状方面均有效,治疗组优于对照组(P<0.05),内镜疗效无显著性差异(P>0.05).结论:半夏泻心汤可显著改善慢性萎缩性胃炎(寒热错杂证)的临床症状.%Objective: To make the curative effect evaluation of Banxia Xiexin Decoction on chronic atrophic gastritis (cold -heat complicated syndrome)based on the calibration biopsy technique. Methods:30 cases met the diagnostic criteria were randomly divided into the treatment group (Banxia Xiexin Decoction group) and the control group ( Weifuchun group) ,3 months was a treatment course. Before and after treatment the clinical symptoms were observed, and pathological changes were observed under gas-troscope biopsy in calibration. Results: Clinical symptoms: two groups in improving the symptoms were valid, the treatment group was better than control group (P 0. 05 ) . Conclusion: Banxia Xiexin Decoction can significantly improve chronic atrophic gastritis(cold-heat complicated syndrome) clinical symptoms.

  11. Genetic alterations in benign lesions: Chronic gastritis and gastric ulcer

    Institute of Scientific and Technical Information of China (English)

    Ana Cristina Gobbo César; Marília de Freitas Calmon; Patrícia Maluf Cury; Alaor Caetano; Aldenis Albaneze Borim; Ana Elizabete Silva

    2006-01-01

    AIM: To investigate the occurrence of chromosome 3, 7,8, 9, and 17 aneuploidies, TP53 gene deletion and p53 protein expression in chronic gastritis, atrophic gastritis and gastric ulcer, and their association with H pylori infection.METHODS: Gastric biopsies from normal mucosa (NM,n = 10), chronic gastritis (CG,n =38), atrophic gastritis (CAG, n=13) and gastric ulcer (GU, n = 21) were studied using fluorescence in situ hybridization (FISH) and immunohistochemical assay. A modified Giemsa staining technique and PCR were used to detect H pylori. An association of the gastric pathologies and aneuploidies with H pylori infection was assessed.RESULTS: Aneuploidies were increasingly found from CG (21%) to CAG (31%) and to GU (62%), involving mainly monosomy and trisomy 7, trisomies 7 and 8, and trisornies 7, 8 and 17, respectively. A significant association was found between H pylori infection and aneuploidies in CAG (P= 0.0143) and GU (P= 0.0498). No TP53 deletion was found in these gastric lesions, but p53-positive immunoreactivity was detected in 45% (5/11) and 12% (2/17) of CG and GU cases, respectively. However, there was no significant association between p53 expression and H pylori infection.CONCLUSION: The occurrence of aneuploidies in benign lesions evidences chromosomal instability in early stages of gastric carcinogenesis associated with H pylori infection, which may confer proliferative advantage. The increase of p53 protein expression in CG and GU may be due to overproduction of the wild-type protein related to an inflammatory response in mucosa.

  12. Therapeutic effect of DA-9601 on chronic reflux gastritis induced by sodium taurocholate in rats

    Institute of Scientific and Technical Information of China (English)

    Tae Young Oh; Chang Yell Shin; Yong Sung Sohn; Dong Hwan Kim; Byoung Ok Ahn; Eun Bang Lee; Cho Hyun Park

    2005-01-01

    AIM: To investigate the therapeutic effects of DA-9601 on sodium taurocholate (TCA)-induced chronic reflux gastritis in SD rats.METHODS: In this study, we have investigated the therapeutic effects of DA-9601 on chronic erosive and atrophic gastritis induced by 6 mo of TCA administration (5 mmol/L in drinking water) in SD rats. RESULTS: Four weeks of DA-9601 administration (0.065%, 0.216% in rat chow), following the withdrawal of TCA treatment, resulted in a significant decrease in total length of erosions in rats in a dose-dependent manner. Furthermore, the indicators of atrophic gastritis, such as reduced mucosal thickness and reduction in the number of parietal cells, were improved by the administration of DA-9601 in a dose-related manner. DA-9601 also attenuated inflammatory cell infiltration and the proliferation of collagenous fiber in the gastric mucosa. The improvement in the reduction of the gastric mucus was observed in the rats receiving a high dose of DA-9601 (0.216%). The therapeutic effect of DA-9601 on experimental chronic erosive gastritis was superior to that of rebamipide (1.08% in rat chow). Biochemical analyses showed increased mucosal prostaglandin E2 and reduced glutathione levels by DA-9601 treatment. CONCLUSION: We suggest that DA-9601 is apromising agent for the treatment of chronic erosive and atrophic gastritis with an etiological factor of bile reflux. Increasedmucosal prostaglandin E2 and reduced glutathione by DA-9601 treatment may be therapeutic mechanisms for chronic erosive and atrophic gastritis.

  13. Relation of atrophic gastritis with Helicobacter pylori-CagA+and interleukin-1 gene polymorphisms

    Institute of Scientific and Technical Information of China (English)

    Rafaela Sierra; Francis Mégraud; Clas Une; Vanessa Ramírez; Warner Alpízar-Alpízar; María I González; José A Ramírez; Antoine de Mascarel; Patricia Cuenca; Guillermo Pérez-Pérez

    2008-01-01

    AIM: To determine the association of Helicobacter pylori (H pylon) CagA+ infection and pro-inflammatory poly-morphisms of the genes interleukin (IL)-IRN and IL-1B with the risk of gastric atrophy and peptic ulcers in a dyspeptic population in Costa Rica, a country with high incidence and mortality of gastric cancer. METHODS: Seven biopsy specimens, a fasting blood sample and a questionnaire concerning nutritional and sociodemographic factors were obtained from 501 con-secutive patients who had undergone endoscopy for dyspeptic symptoms. A histopathological diagnosis was made. Pepsinogen concentrations were analyzed by enzyme linked immunosorbent assay (ELISA). Infection with H pylori CagA* was determined by serology and polymerase chain reaction (PCR). IL-1B and IL-1RN polymorphisms genotyping was performed by PCR-restriction fragment length polymorphism (PCR-RFLP) and PCR respectively. RESULTS: In this dyspeptic population, 86% wereHpy/ori positive and of these, 67.8% were positive forCagA. Atrophic antral gastritis (AAG) was associatedwith CagA+ status [odd ratio (OR) = 4.1; P < 0.000]and fruit consumption (OR = 0.3; P < 0.00). Atrophicbody gastritis (ABG) was associated with pepsinogenPGI/PGII < 3.4 (OR = 4.9; P < 0.04) and alcoholconsumption (OR = 7.3; P < 0.02). Duodenal ulcerwas associated with CagA+ (OR = 2.9; P < 0.04) andsmoking (OR = 2.4; P < 0.04). PGI < 60 μg/L as wellas PGI/PGII < 3.4 were associated with CagA+. CONCLUSION: In a dyspeptic population in Costa Rica,H pylori CagA+ is not associated with ABG, but it is arisk factor for AAG. The pro-inflammatory cytokine poly-morphisms IL-1B + 3945 and IL-1RN are not associatedwith the atrophic lesions of this dyspeptic population.

  14. Study on histogenesis of enterochromaffin-like carcinoid in autoimmune atrophic gastritis associated with pernicious anemia

    Directory of Open Access Journals (Sweden)

    Mačukanović-Golubović Lana

    2007-01-01

    Full Text Available Background/Aim. Autoimmune atrophic fundic gastritis induces the pernicious anemia (PA, as well as the changes in both epithelium and endocrine cells of gastric mucosa. The most important complications are: achlorhydria, hypergastrinemia, gastric cancer and enterochromaffin-like ( ECL carcinoid. The aim of this study was to examine ECL carcinoid histogenesis in A-gastritis associated with PA. Methods. During the period from 2000−2006, 65 patients with PA and 30 patients of the control group were examined. Histopathological examination was done in endoscopical biopsies of gastric mucosa fixed in 10% formaldehyde. Paraffin sections were stained with classic hematoxylin-eosin (HE; histochemical AB-PAS (pH 2.5, cytochemical argyrophilic Servier-Munger′s and immunocytochemical PAP methods for G cell identification and chromogranin A antibodies - specific marker for neuroendocrine ECL cells. Both G and ECL cells were counted per 20 fields, of surface 0.0245312 mm2 by a field. Basal gastrin serum levels were also examined by using radioimmunoassay (RIA method. The obtained results were statisticaly calculated by using Student΄s t test. Results. Marked antral G cell hyperplasia associated with corporal ECL hyperplasia was found. ECL cell hyperplasia was of simplex, linear, adenomatoid type to the pattern of intramucous ECL cell carcinoid. An average number of G cells was statistically significant in the patients with PA as compared to the control group (p < 0.05 as well as an average number of ECL cells. Conclusion. We concluded that antral G cell hyperplasia accompanied by gastrinemia induces ECL hyperplasia and ECL corporal carcinoid in A-gastritis and that their histogenesis develops trough simple, linear and adenomatoide hyperplasia. .

  15. Atrophic gastritis and gastric cancer%萎缩性胃炎与胃癌的关系

    Institute of Scientific and Technical Information of China (English)

    台卫平

    2008-01-01

    在许多肿瘤中可以观察到微生物所引起的慢性炎症,尤其是在胃肠道中.萎缩性胃炎被认为是胃癌的癌前病变.动物实验和人体研究均证实,幽门螺杆菌(Hp)在胃癌发病和进展中起重要作用,可以导致萎缩、组织转化、不典型增生及胃癌.%In many cancers the chronic inflammation caused by microorganisms can be observed, espe-cially in gastrointestinal system. Atrophic gastritis is thought to be a precancerous lesion. Studies have approved that Helicobacter pylori plays an important role in the genesis and development of gastric caner. It is now known to be responsible for inducing chronic gastric inflammation that progresses to atrophy, metaplasia, dysplasia and gastric cancer.

  16. 慢性萎缩性胃炎中医证型与幽门螺杆菌感染、病理分级的相关性研究%Study on correlation of syndrome types of TCM with H.pylori infection and pathological grade in chronic atrophic gastritis

    Institute of Scientific and Technical Information of China (English)

    宗湘裕; 王万卷; 刘宝珍; 杜长海; 赵景成

    2015-01-01

    Objective It is to study the relationship between H.pylori infection and pathological grade in chronic atrophic gastritis with syndrome types of TCM.Methods 106 cases of patients with chronic atrophic gastritis diagnosed by gastroscopy and pathology were divided into five groups according to TCM syndrome differentiation: spleen-stomach deficiency group, spleen-stomach dampness-heat group, stomach Yin deficiency group,liver and stomach disharmony group and blood stagna-tion of stomach collaterals group.The relationship of distribution of syndrome types of TCM with H.pylori infection, atrophy, intestinal metaplasia,dysplasia degree was observed and compared.Results Chronic atrophic gastritis in proportion from high to low were spleen and stomach deficiency type, dampness-heat of spleen and stomachtype, liver and stomach disharmony type,stomach Yin deficiency type and blood stagnation of stomach collaterals type.The total infection rates in proportion from high to low were dampness-heat of spleen and stomach type,liver and stomach disharmony type, blood stagnation of stomach collaterals type, spleen and stomach deficiency type, stomach Yin deficiency type, and the total infection rate was 58.49%. Mild atrophy of liver stomach disharmony of the ratio was higher.The proportion of spleen stomach damp heat syndrome, blood stasis syndrome of stomach meridian,stomach Yin deficiency syndrome in severe atrophy degree were higher than that of spleen and stomach weakness, liver and stomach disharmony type.No significant difference in proportion of mild to moderate atrophy, intestinal metaplasia among the five groups was found.The proportion of mild dysplasia was higher in spleen stomach damp heat syndrome, blood stasis syndrome than that in spleen and stomach deficiency syndrome,syndrome of incoordination between liv-er and stomach, deficiency of stomach Yin syndrome.The degree of gastric precancerous lesions of stomach meridian in the blood stasis was the highest, followed by

  17. Artificial neural networks in the recognition of the presence of thyroid disease in patients with atrophic body gastritis

    Institute of Scientific and Technical Information of China (English)

    Edith Lahner; Marco Intraligi; Massimo Buscema; Marco Centanni; Lucy Vannella; Enzo Grossi; Bruno Annibale

    2008-01-01

    AIM: To investigate the role of artificial neural networks in predicting the presence of thyroid disease in atrophic body gastritis patients.METHODS: A dataset of 29 input variables of 253 atrophic body gastritis patients was applied to artificial neural networks (ANNs) using a data optimisation procedure (standard ANNs, T&T-IS protocol, TWIST protocol). The target variable was the presence of thyroid disease.RESULTS: Standard ANNs obtained a mean accuracy of 64.4% with a sensitivity of 69% and a specificity of 59.8% in recognizing atrophic body gastritis patients with thyroid disease. The optimization procedures (T&T-IS and TWIST protocol) improved the performance of the recognition task yielding a mean accuracy, sensitivity and specificity of 74.7% and 75.8%, 78.8% and 81.8%, and 70.5% and 69.9%, respectively. The increase of sensitivity of the TWIST protocol was statistically significant compared to T&T-IS.CONCLUSION: This study suggests that artificial neural networks may be taken into consideration as a potential clinical decision-support tool for identifying ABG patients at risk for harbouring an unknown thyroid disease and thus requiring diagnostic work-up of their thyroid status.

  18. Can chronic gastritis cause an increase in fecal calprotectin concentrations?

    Science.gov (United States)

    Montalto, Massimo; Gallo, Antonella; Ianiro, Gianluca; Santoro, Luca; D’Onofrio, Ferruccio; Ricci, Riccardo; Cammarota, Giovanni; Covino, Marcello; Vastola, Monica; Gasbarrini, Antonio; Gasbarrini, Giovanni

    2010-01-01

    AIM: To evaluate fecal calprotectin concentrations (FCCs) in subjects with chronic gastritis and the correlation between FCCs and gastritis activity score. METHODS: FCCs were measured in 61 patients with histological diagnosis of gastritis and in 74 healthy volunteers. Histological grading of gastritis was performed according to the updated Sydney gastritis classification. Patients were subdivided into 2 groups according to the presence/absence of an active gastritis. Patients with chronic active gastritis were divided into 3 subgroups on the basis of the activity score (mild, moderate, marked). FFCs in relation to Helicobacter pylori (H. pylori) infection and proton pump inhibitor (PPI) use were also evaluated. RESULTS: FCCs in patients with chronic active gastritis were not significantly different to FCCs either in subjects with non active gastritis or in healthy controls. Among patients with chronic active gastritis (even marked), FCCs did not significantly differ according to activity score. No significant differences in FCCs were found when considering H. pylori, as well as when considering PPI chronic use. CONCLUSION: FCCs were not significantly increased in subjects with chronic gastritis, even in those patients with a marked neutrophil infiltration. PMID:20632443

  19. Clinical Usefulness of the Serological Gastric Biopsy for the Diagnosis of Chronic Autoimmune Gastritis

    Directory of Open Access Journals (Sweden)

    Antonio Antico

    2012-01-01

    Full Text Available Aim. To assess the predictive value for chronic autoimmune gastritis (AIG of the combined assay of anti-parietal-cell antibodies (PCA, anti-intrinsic-factor antibodies (IFA, anti-Helicobacter pylori (Hp antibodies, and measurement of blood gastrin. Methods. We studied 181 consecutive patients with anemia, due to iron deficiency resistant to oral replacement therapy or to vitamin B12 deficiency. Results. 83 patients (45.8% tested positive for PCA and underwent gastroscopy with multiple gastric biopsies. On the basis of the histological diagnosis, PCA-positive patients were divided into 4 groups: (1 30 patients with chronic atrophic gastritis; they had high concentrations of PCA and gastrin and no detectable IFA; (2 14 subjects with metaplastic gastric atrophy; they had high PCA, IFA, and gastrin; (3 18 patients with nonspecific lymphocytic inflammation with increased PCA, normal gastrin levels, and absence of IFA; (4 21 patients with multifocal atrophic gastritis with “borderline” PCA, normal gastrin, absence of IFA and presence of anti-Hp in 100% of the cases. Conclusions. The assay of four serological markers proved particularly effective in the diagnostic classification of gastritis and highly correlated with the histological profile. As such, this laboratory diagnostic profile may be considered an authentic “serological biopsy.”

  20. Histopathological Characteristics of Atrophic Gastritisin Adult Population

    Institute of Scientific and Technical Information of China (English)

    Marija Milicevic; Snezana Bozanic; Nenad Solajic

    2015-01-01

    Introduction: Chronic gastritis is inflammation of the gastric mucosa. It can be non-atrophic and atrophic. Atrophy isdefined as the loss of appropriate glands. It is frequently located in antral mucosa as consequence of Helicobacter pylori infectionand it is associated with intestinal gastric cancer. Goal: Describe histopathological and demographic characteristics of atrophicgastritis. Matherial and methods: We assessed the pathological reports of 100 patients with atrophic gastritis whose characteristicswere evaluated by using a semiquantitative scale of Sidney system of classification of gastritis. To assess the significance betweenthe incidence of various parametres we used ;~2 test. Results: We found that the difference in frequency of atrophic gastritis betweenmen and women was not statistically significant. The difference in distribution is statistically significant in favor of the antrum.Among patients who have atrophy with Helicobacterpylori infection and intestinal metaplasia and those who do not have metaplasia,it was found that the difference is highly statistically significant. Conclusion: The most frequent localisation of atrophic gastritis isantral mucosa. There is no difference between men and women in frequency of atrophic gastritis, while the aging is related with moreoften occurrence of atrophic gastritis.

  1. Reverse effects of Chinese drug Shenfouweikang herbs on chronic atrophic gastritis in rats%参佛胃康对大鼠慢性萎缩性胃炎及胃癌前病变逆转作用的研究

    Institute of Scientific and Technical Information of China (English)

    蔺焕萍; 王小平; 付倩; 李守朝

    2012-01-01

    Objective: To determine the reverse effect of Shenfouweikang herbs on experimental chronic atrophic gastritis( CAG )in rats. Methods: CAG model in rats was made using complex methods of active immunization combined with oral administration of sodium deoxycholate and hot water for 90 d. Five animal groups were divided. Empty control group was fed with water, while experimental animal groups were fed with distilled water, 0. 018mg Liz-hudele herds solution per kg weight of rat, 2.44mg high dose and 0. 61 mg low dose of Shenfouweikang herbs solutionper kg weight of rat for 90 days. Then the acidity of gastric juice was measured using acid - base balance. Pathology of rat gastric mucous morphology was examined by general observation and microscopy. At the same time, rat gastric pH value and pepsin content were detected by spectrophotometer. Results: After treated with Shenfouweikang herbs, rat gastric pH value and pepsin content increased and gastric mucous morphology was recovered, which presented a significant effect with high dose of Shenfouweikang herbs. Conclusion: Shenfouweikang herbs demonstrated a distinct preventive and protective effect on chronic atrophic gastritis( CAG )in rats.%目的 观察参佛胃康对大鼠慢性萎缩性胃炎及胃癌前病变的逆转作用,探讨其作用机制.方法 采用主动免疫、去氧胆酸钠、热水灌胃综合法连续造模90d,复制慢性萎缩性胃炎(CAG)大鼠模型,空白组自由饮水,模型组用等体积的蒸馏水灌胃,丽珠得乐组用丽珠得乐溶液0.018mg/kg灌胃,参佛胃康大剂量组、参佛胃康小剂量组分别用参佛胃康溶液2.44mg/kg和0.61mg/kg灌胃.肉眼观察胃黏膜的变化,光镜下观察胃黏膜的病理学改变,同时测定大鼠胃液pH值及胃蛋白酶活性的变化.结果 参佛胃康能保护大鼠慢性胃黏膜损伤,增加胃液酸度提高胃蛋白酶活性,且参佛胃康大剂量组效果显著.结论 参佛胃康对慢性胃萎缩性胃炎黏膜的各

  2. Short Term Efficacy of Ten-day Standard Sequential Therapy Combined With Dental Scaling on Helicobacter Pylori ;Eradication in Patients With Chronic Atrophic Gastritis%序贯疗法联合口腔洁治对慢性萎缩性胃炎患者胃幽门螺杆菌根除的近期疗效研究

    Institute of Scientific and Technical Information of China (English)

    孙佩玉

    2015-01-01

    Objective To investigate the efficacy of ten-day standard sequential therapy combined with dental scaling therapy on helicobacter pylori( Hp)in patients with chronic atrophic gastritis. Methods A total of 132 patients with chronic atrophic gastritis and positive Hp in both stomach and oral cavity were enrolled from Gastroenterology Department of the First Hospital of Jiaxing from January,2013 to January,2014 and were randomly assigned into observation group(n =62)and control group( n =70 ) . The observation group received ten -day standard sequential therapy combined with dental scaling therapy. The control group received ten-day standard sequential therapy only. Before treatment,one month and 3 months after treatment,two groups were compared by gastric Hp eradication rate,oral Hp positive rate and scores of pathological mechanism and symptoms. Results One month after treatment,two groups were significantly different in gastric Hp eradication rate and oral Hp positive rate(P﹤0. 05). Before treatment,two groups were not significantly different in scores of pathological mechanism and symptoms(P﹥0. 05);One month after treatment,significant differences occurred between two groups(P﹤0. 05). Three months after treatment,two groups were significantly different in gastric Hp eradication rate and oral Hp positive rate ( P ﹤0. 05 ). Conclusion Ten-day standard sequential therapy combined with dental scaling therapy has better Hp eradication effect and safety on patients with chronic atrophic gastritis.%目的:探讨序贯疗法联合口腔洁治对慢性萎缩性胃炎患者胃幽门螺杆菌( Hp)根除的近期疗效。方法将2013年1月—2014年1月在我院消化科门诊就诊的慢性萎缩性胃炎且胃、口腔Hp阳性患者132例作为研究对象,采用随机数字表法分为治疗组62例和对照组70例。治疗组给予10 d序贯疗法和口腔洁治法,对照组单纯给予10 d序贯疗法。比较两组治疗前、治疗后1

  3. 甘露消毒丹加减方治疗 Hp 感染的慢性萎缩性胃炎的临床疗效和安全性观察%The clinical efficacy and safety of Ganluxiaodu micropills in treatment of Hp infected chronic atrophic gastritis

    Institute of Scientific and Technical Information of China (English)

    陈刚

    2016-01-01

    提高标准三联疗法的 Hp 根除率,治疗 Hp 感染的慢性萎缩性胃炎(脾虚湿热型)临床疗效显著,值得临床推广应用。%Objective To investigate the clinical efficacy and safety of Ganluxiaodu micropills in treatment of helicobacter pylori(Hp)infected chronic atrophic gastritis.Methods 120 patients with chronic atrophic gastritis (pixu shire syndrome)from April 2013 to April 2014 were selected and divided into observation group and the control group (n =60)according to random number table method.The control group was given standard triple therapy,the observation group was given Ganluxiaodu micropills on the basis of the control group,7 days for a period of treatment. The symptoms changes of the two groups before and after treatment were observed and combined results of the gastro-scope and breath test,determined the clinical curative effect and eradication rate of Hp.The SF -36 scale score was used to evaluate the quality of life of the patients.Results The clinical symptom scores[(15.92 ±2.25)points vs (16.12 ±2.14)points ],SF -36 scale [(68.05 ±12.98)points vs (65.77 ±11.34)points]of the two groups before treatment had no statistically significant differences (t =-1.033,-1.239,all P >0.05).The clinical symp-tom scores and SF -36 score of the observation group and the control group after treatment [(8.24 ±1.23)points, (89.44 ±12.93)points;(12.65 ±1.75)points,(77.43 ±11.59)points ]were obviously improved than before treat-ment,the differences were statistically significant (t =2.574,2.765,2.133,2.047,all P 0.05).Conclusion Ganluxiaodu micropills can improve the Hp eradicate rate of standard triple therapy,the clinical efficacy of Ganluxiaodu micropills in treatment of Hp infected chronic atrophic gastritis (pixu shire syndrome)is significant,which is worthy of clinical popularization and application.

  4. Review on Clinical and Mechanism Studies of Moxibustion Therapy for Chronic Gastritis

    Institute of Scientific and Technical Information of China (English)

    Zhu Hui-wen; Ruan Chun-xun; Cao Shu-fei; Wu Huan-gan; Li Jing

    2014-01-01

    By computer research, the literature of clinical and experimental studies on moxibustion therapy for chronic gastritis in the recent fifteen years was collected, sorted and analyzed, in order to understand the general situation about the clinical and experimental studies on moxibustion therapy for chronic gastritis, summarize the regularity of moxibustion therapy for chronic gastritis, so as to guide the treatment of chronic gastritis.

  5. Impact of catgut embedding therapy on expression of IKKβ, IкB, NF-кB in gastric mucosa of chronic atrophic gastritis model rats%穴位埋线对慢性萎缩性胃炎模型大鼠IKKβ、IкB、NF-кB表达的影响

    Institute of Scientific and Technical Information of China (English)

    钟国新; 李素荷; 陈璐; 张旋; 樊永磊; 黄志毅

    2013-01-01

    目的:探讨穴位埋线对慢性萎缩性胃炎(CAG)模型大鼠胃黏膜组织IKKβ、IкB、NF-кB表达的影响.方法:将50只SD大鼠随机分为空白组10只和造模组40只,造模组采用自由饮用浓度为100μg/L的MNNG溶液,同时配合饥饱失常法进行造模,造模成功后随机分为模型组10只,埋线组10只,假埋线组10只.所有大鼠正常条件下喂养,埋线组选取大鼠“足三里”、“中脘”、“脾俞”穴行埋线疗法治疗,假埋线组仅用埋线针针刺上述穴位治疗,每10d治疗1次,共治疗6次.采用免疫组化检测各组大鼠胃黏膜组织IKKβ、IкB、NF-кB表达情况,并采用图像分析系统行半定量分析.结果:与空白组比较,模型组和假埋线组大鼠胃黏膜组织IKKβ、IкB、NF-кB表达显著升高(P<0.01),埋线组表达升高(P<0.05);与模型组比较,埋线组表达显著降低(P<0.01),假埋线组则差异无统计学意义.结论:穴位埋线疗法可以抑制IKKβ活化,进而抑制IкB降解,从而降低NF-кB活化水平,对慢性萎缩性胃炎具有较好的治疗作用.%Objective: To explore the impact of catgut embedding in points therapy on expression of IKKβ, IκB, NF-κB in gastric mucosa of chronic atrophic gastritis (CAG) model rats. Methods: 50 SD rats were randomly divided into the normal control group with 10 rats and the model group with 40 rats. With irregular diet method, the model group was modeled by drinking MNNG solution freely with concentration of 100μg/L. After the CAG was detected by immunohistochemeical detection and analyzed half-quantitatively model was confirmed succeeded, they were randomly divided into the model group, catgut embedding group and fake catgut embedding group, 10 rats with each group. All rats were fed under normal conditions. The embedding group was treated by embedding catgut in the points of Zusanli (ST36), Zhongwan (RN12) and Pishu (DL20) every 10 days, 6 times in total, while those in fake catgut

  6. Therapeutic effect of egualen sodium (KT1-32), a new antiulcer agent, on chronic gastritis induced by sodium taurocholate in rats.

    Science.gov (United States)

    Mochizuki, S; Matsumoto, M; Wakabayashi, S; Kosakai, K; Tomiyama, A; Kishimoto, S

    1996-12-01

    We investigated the therapeutic effects of egualen sodium (KT1-32), a new antiulcer agent, on chronic erosive and atrophic gastritis induced by 5 months' administration of sodium taurocholate (TCA; 5 mM) in rats. The chronic gastritis was manifested by mucosal surface injuries (erosions), reduced mucosal thickness, reduction of the number of parietal cells, infiltration of inflammatory cells, and proliferation of collagenous fiber. Egualen sodium, (10-100 mg/kg, t.i.d.) administered orally to the rats for 2 weeks after the withdrawal of TCA, dose-dependently and significantly decreased the total length of erosions. The indicators of atrophic gastritis, i.e., reduced mucosal thickness and reduction in the number of parietal cells, were improved dose-dependently by the administration of this agent. Egualen sodium also reduced the inflammatory cell infiltration and the proliferation of collagenous fiber in the gastric mucosa in a dose-dependent manner. The reduced staining of neutral gastric mucus was improved by a high dose (100 mg/kg) of egualen sodium. The therapeutic effects of egualen sodium on experimental gastritis were superior to those of sofalcone and sodium guaiazulene 3-sulfonate. These results suggest that egualen sodium may be a promising agent for the treatment of erosive and atrophic gastritis. PMID:9027640

  7. 加味七方胃痛颗粒对慢性萎缩性胃炎大鼠胃蛋白酶含量及HSP70蛋白表达的影响%Effect of Modified Qifang Weitong Granules on Pepsin Content and Heat Shock Protein 70 Expression in Rats with Chronic Atrophic Gastritis

    Institute of Scientific and Technical Information of China (English)

    唐梅文; 王伟; 李桂贤; 岳小红; 陈国忠; 邓嫦

    2011-01-01

    Objective To investigate the effects of Modified Qifan Weitong Granules(QWG) on pepsin content and heat shock protein 70(HSP70) expression in the gastric mucosa of rats with chronic atrophic gastritis(CAG).Methods CAG rat models were established by means of N-methyl-N'-nitro-N-nitrosoguanidine(MNNG), and the effect of QWG on relative indexes was observed and compared with that of Weifuchun Granules. Results Compared with the model group, the atrophy and intestinal metaplasia of gastric mucosa were relieved in large-and medium-dosage QWG groups and in Weifuchun Granules group, and the pepsin content and HSP70 expression were increased in large-, medium-and small-dosage QWG groups and in Weifuchun Granules group, the difference being significant(P< 0.01). Compared with Weifuchun Granules group, pepsin content and HSP70 expression in large-dosage QWG group were increased with statistical significance(P < 0.05). Conclusion The mechanism of QWG in preventing and treating CAG may be related with prevention of gastric mucosa through increasing pepsin con tent and HSP70 expression.%目的 探讨加味七方胃痛颗粒对慢性萎缩性胃炎(CAC)模型大鼠胃黏膜组织中胃蛋白酶含量及热休克蛋白70(HSP70)表达的影响.方法 采用化学致癌物N-甲基-N'-硝基-N-亚硝基胍(MNNG)建立CAG动物模型,以胃复春为对照组,观察加味七方胃痛颗粒对大鼠CAG相关指标的作用.结果 与模型组比较,加味七方胃痛颗粒高、中剂量组和胃复春组的胃黏膜萎缩程度、胃黏膜肠化生程度明显减轻(P<0.01);加味七方胃痛颗粒高、中、低剂量组和胃复春组胃蛋白酶的含量、HSP70蛋白表达显著增加(P<0.01);与胃复春组比较,加味七方胃痛颗粒高剂量组胃蛋白酶的含量、HSP70蛋白表达显著增加(P<0.05).结论 加味七方胃痛颗粒防治CAG的作用机制可能是通过升高胃蛋白酶的含量及促进HSP70的表达,从而发挥对黏膜保护作用.

  8. Chronic gastritis rat model and role of inducing factors

    Institute of Scientific and Technical Information of China (English)

    Zun Xiang; Jian-Min Si; Huai-De Huang

    2004-01-01

    AIM: To establish an experimental animal model of chronic gastritis in a short term and to investigate the effects of several potential inflammation-inducing factors on rat gastric mucosa.METHODS: Twenty-four healthy, male SD rats were treated with intragastric administration of 600 mL/L alcohol, 20mmol/L sodium deoxycholate and 0.5 g/L ammonia (factor A), forage containing low levels of vitamins (factor B), and/or indomethacin (factor C), according to an L8(27)orthogonal design. After 12 wk, gastric antral and body mucosae were pathologically examined.RESULTS: Chronic gastritis model was successfully induced in rats treated with factor A for 12 wk. After the treatment of animals, the gastric mucosal inflammation was significantly different from that in controls, and the number of pyloric glands at antrum and parietal cells at body were obviously reduced (P<0.01). Indomethacin induced gastritis but without atrophy, and short-term vitamin deficiency failed to induce chronic gastritis and gastric atrophy, In addition,indomethacin and vitamin deficiency had no synergistic effect in inducing gastritis with the factor A. No atypical hyperplasia and intestinal metaplasia in the gastric antrum and body were observed in all rats studied.CONCLUSION: Combined intragastric administration of 600 mL/L alcohol, 20 mmol/L sodium deoxycholate and 0.5 g/L ammonia induces chronic gastritis and gastric atrophy in rats. Indomethacin induces chronic gastritis only.The long-term roles of these factors in gastric inflammation and carcinogenesis need to be further elucidated.

  9. Study on correlation of pathological changes of chronic atrophic gastritis gastric mucosal precancerous lesions with TCM syndrome type and TRPV1, TRPM8%慢性萎缩性胃炎胃黏膜癌前病变病理变化与中医证型及 TRPV1、TRPM8的相关性研究

    Institute of Scientific and Technical Information of China (English)

    王俊; 黄雅慧

    2014-01-01

    Objective It is to observe the correlation of pathological changes of chronic atrophic gastritis ( CAG) precan-cerous lesions with TCM syndrome type and transient receptor potential (TRPV1, TRPM8), and provide more objective basis of TCM syndrome differentiation for CAG .Methods317 patients with CAG diagnosed by endoscopy and CAG with atypical hy-perplasia or different levels intestinal metaplasia diagnosed by pathology were selected ;10 cases with asymptomatic superficial gastritis found by regular physical examination were selected as a control .The detection of TRPV1 receptors , TRPM8 expres-sion and the CAG syndrome types of TCM syndrome differentiation were done , and the correlation of pathological changes of CAG with TCM syndrome type and the correlation of TRPV 1, TRPM8 expression were analyzed ,Results①The TCM syndrome type of CAG precancerous lesions were accorded to the sort of spleen deficiency and Qi stagnation >Spleen stomach damp heat >weakness of spleen and stomach >Liver stomach disharmony >Stomach yin deficiency >stomach collaterals stasis resistance .②There were significant difference in the expression of TRPV 1 and TRPM8 between the six TCM syndrome types . The syndrome types were sorted to Spleen stomach damp heat >Stomach yin deficiency >Liver stomach disharmony >stom-ach collaterals stasis resistance >spleen deficiency and Qi stagnation >weakness of spleen and stomach for TRPV 1 expres-sion and sorted to weakness of spleen and stomach >spleen deficiency and Qi stagnation >stomach collaterals stasis resist-ance >Liver stomach disharmony >Stomach yin deficiency >Spleen stomach damp heat for TRPM 8 expression .TRPV1 was expressed obviously in Spleen stomach damp heat type at 415 bp, TRPM8was expressed obviously in weakness of spleen and stomach type at387 bp.stomach collaterals stasis resistance type was similar the expression of superficial gastritis gastric mu -cosa.③There was significant difference in the same syndrome among different

  10. Childhood chronic gastritis and duodenitis: Role of altered sensory neuromediators

    Science.gov (United States)

    Islek, Ali; Yilmaz, Aygen; Elpek, Gulsum Ozlem; Erin, Nuray

    2016-01-01

    AIM To investigate the roles of the neuropeptides vasoactive intestinal peptide (VIP), substance P (SP), and calcitonin gene-related peptide (CGRP) in chronic gastritis and duodenitis in children. METHODS Biopsy samples from the gastric and duodenal mucosa of 52 patients and 30 control subjects were obtained. Samples were taken for pathological examination, immunohistochemical staining, enzyme activity measurements and quantitative measurements of tissue peptide levels. RESULTS We observed differential effects of the disease on peptide levels, which were somewhat different from previously reported changes in chronic gastritis in adults. Specifically, SP was increased and CGRP and VIP were decreased in patients with gastritis. The changes were more prominent at sites where gastritis was severe, but significant changes were also observed in neighboring areas where gastritis was less severe. Furthermore, the degree of changes was correlated with the pathological grade of the disease. The expression of CD10, the enzyme primarily involved in SP hydrolysis, was also decreased in patients with duodenitis. CONCLUSION Based on these findings, we propose that decreased levels of VIP and CGRP and increased levels of SP contribute to pathological changes in gastric mucosa. Hence, new treatments targeting these molecules may have therapeutic and preventive effects. PMID:27729741

  11. Collagenous gastritis.

    Science.gov (United States)

    Jin, Xiaoyi; Koike, Tomoyuki; Chiba, Takashi; Kondo, Yutaka; Ara, Nobuyuki; Uno, Kaname; Asano, Naoki; Iijima, Katsunori; Imatani, Akira; Watanabe, Mika; Shirane, Akio; Shimosegawa, Tooru

    2013-09-01

    In the present paper, we report a case of rare collagenous gastritis. The patient was a 25-year-old man who had experienced nausea, abdominal distention and epigastralgia since 2005. Esophagogastroduodenoscopy (EGD) carried out at initial examination by the patient's local doctor revealed an extensively discolored depression from the upper gastric body to the lower gastric body, mainly including the greater curvature, accompanied by residual mucosa with multiple islands and nodularity with a cobblestone appearance. Initial biopsies sampled from the nodules and accompanying atrophic mucosa were diagnosed as chronic gastritis. In August, 2011, the patient was referred to Tohoku University Hospital for observation and treatment. EGD at our hospital showed the same findings as those by the patient's local doctor. Pathological findings included a membranous collagen band in the superficial layer area of the gastric mucosa, which led to a diagnosis of collagenous gastritis. Collagenous gastritis is an extremely rare disease, but it is important to recognize its characteristic endoscopic findings to make a diagnosis. PMID:23363075

  12. Dr.Zhu Hongming's Experience in Treating Chronic Gastritis

    Institute of Scientific and Technical Information of China (English)

    朱传伟

    2004-01-01

    @@ Dr. Zhu Hongming has engaged in TCM internal medicine for more than 40 years and accumulated rich clinical experience, especially in the treatment of diseases of the spleen and stomach. The following is a brief introduction to his experience in TCM differential treatment of chronic gastritis.

  13. Possible contribution of artificial neural networks and linear discriminant analysis in recognition of patients with suspected atrophic body gastritis

    Institute of Scientific and Technical Information of China (English)

    Edith Lahner; Enzo Grossi; Marco Intraligi; Massimo Buscema; Vito D Corleto; Gianfranco Delle Fave; Bruno Annibale

    2005-01-01

    AIM: To investigate whether ANNs and LDA could recognize patients with ABG in a database, containing only clinical and biochemical variables, of a pool of patients with and without ABG, by selecting the most predictive variables and by reducing input data to the minimum.METHODS: Data was collected from 350 consecutive outpatients (263 with ABG, 87 with non-atrophic gastritis and/or celiac disease [controls]). Structured questionnaires with 22 items (anagraphic, anamnestic, clinical, and biochemical data) were filled out for each patient. All patients underwent gastroscopy with biopsies. ANNs and LDA were applied to recognize patients with ABG.Experiment 1: random selection on 37 variables, experiment 2: optimization process on 30 variables, experiment 3:input data reduction on 8 variables, experiment 4: use of only clinical input data on 5 variables, and experiment 5:use of only serological variables.RESULTS: In experiment 1, overall accuracies of ANNs and LDA were 96.6% and 94.6%, respectively, for predicting patients with ABG. In experiment 2, ANNs and LDA reached an overall accuracy of 98.8% and 96.8%,respectively. In experiment 3, overall accuracy of ANNs was 98.4%. In experiment 4, overall accuracies of ANNs and LDA were, respectively, 91.3% and 88.6%. In experiment 5, overall accuracies of ANNs and LDA were,respectively, 97.7% and 94.5%.CONCLUSION: This preliminary study suggests that advanced statistical methods, not only ANNs, but also LDA,may contribute to better address bioptic sampling during gastroscopy in a subset of patients in whom ABG may be suspected on the basis of aspecific gastrointestinal symptoms or non-digestive disorders.

  14. The interaction effects of pri-let-7a-1 rs10739971 with PGC and ERCC6 gene polymorphisms in gastric cancer and atrophic gastritis.

    Directory of Open Access Journals (Sweden)

    Qian Xu

    Full Text Available BACKGROUND: The aim of this study was to investigate the interaction effects of pri-let-7a-1 rs10739971 with pepsinogen C (PGC and excision repair cross complementing group 6 (ERCC6 gene polymorphisms and its association with the risks of gastric cancer and atrophic gastritis. We hoped to identify miRNA polymorphism or a combination of several polymorphisms that could serve as biomarkers for predicting the risk of gastric cancer and its precancerous diseases. METHODS: Sequenom MassARRAY platform method was used to detect polymorphisms of pri-let-7a-1 rs10739971 G → A, PGC rs4711690 C → G, PGC rs6458238 G → A, PGC rs9471643 G → C, and ERCC6 rs1917799 in 471 gastric cancer patients, 645 atrophic gastritis patients and 717 controls. RESULTS: An interaction effect of pri-let-7a-1 rs10739971 polymorphism with ERCC6 rs1917799 polymorphism was observed for the risk of gastric cancer (P interaction = 0.026; and interaction effects of pri-let-7a-1 rs10739971 polymorphism with PGC rs6458238 polymorphism (P interaction = 0.012 and PGC rs9471643 polymorphism (P interaction = 0.039 were observed for the risk of atrophic gastritis. CONCLUSION: The combination of pri-let-7a-1 rs10739971 polymorphism and ERCC6 and PGC polymorphisms could provide a greater prediction potential than a single polymorphism on its own. Large-scale studies and molecular mechanism research are needed to confirm our findings.

  15. Promoter polymorphisms in trefoil factor 2 and trefoil factor 3 genes and susceptibility to gastric cancer and atrophic gastritis among Chinese population.

    Science.gov (United States)

    Xu, Qian; Chen, Mo-Ye; He, Cai-Yun; Sun, Li-Ping; Yuan, Yuan

    2013-10-15

    The polymorphisms in trefoil factor (TFF) gene family that protect gastrointestinal epithelium might influence individual vulnerability to gastric cancer (GC) and atrophic gastritis. We used the Sequenom MassARRAY platform to identify the genotypes of TFF2 rs3814896 and TFF3 rs9981660 polymorphisms in 478 GC patients, 652 atrophic gastritis patients, and 724 controls. For the TFF2 rs3814896 polymorphism, in the subgroup aged ≤ 50 years, we found that AG+GG genotypes were associated with a 0.746-fold decreased risk of atrophic gastritis [p=0.023, 95% confidence interval (CI)=0.580-0.960], a 0.626-fold decreased risk of GC (p=0.005, 95% CI=0.451-0.868), and a 0.663-fold decreased risk of diffuse-type GC (p=0.034, 95% CI=0.452-0.970) compared with the common AA genotype. For the TFF3 rs9981660 polymorphism, in the male subgroup, individuals with variant AG+AA genotype were associated with a 0.761-fold decreased risk of diffuse-type GC compared with the common GG genotype (p=0.043, 95% CI=0.584-0.992). Additionally, we found that in subjects aged ≤ 50 years compared with common AA genotype, TFF2 rs3814896 AG+GG genotypes were associated with increased TFF2 mRNA levels in the total gastric cancer specimens and in the diffuse-type gastric cancer specimens; and in males aged ≤ 50 years compared with common GG genotype, TFF3 rs9981660 AA+AG genotypes were associated with TFF3 mRNA levels in diffuse-type gastric cancer tissues and their corresponding non-cancerous tissues. To our knowledge, this is the first report of an association between the TFF2 rs3814896 AG+GG genotypes and decreased risks of GC, diffuse-type GC, and atrophic gastritis in younger people aged ≤ 50 years, and an association between TFF3 rs9981660 AG+AA genotype and decreased risk of diffuse-type GC in men. Moreover, we found that TFF2 rs3814896 AG+GG genotypes in people aged ≤ 50 years and TFF3 rs9981660 AG+AA genotypes in younger males with diffuse-type GC were associated with higher levels of

  16. Chemical gastritis after chronic bromazepam intake: a case report

    Directory of Open Access Journals (Sweden)

    Krakamp Bernd

    2010-07-01

    Full Text Available Abstract Background We describe a rare case of diffuse macroscopic discoloration and chemical gastritis due to chronic bromazepam intake. The chemical composition of pharmaceuticals has to be considered at endoscopy and it is evident that some chemical substances damage the epithelial tissue and lead to clinical symptoms. Case Presentation Endoscopy was performed in an 82-year-old patient due to gastroesophageal reflux symptoms and epigastric pain. Gastroscopy showed a hiatal hernia and a scarred duodenal bulb. More striking was the yellow-brownish discoloration of the gastric and the duodenal mucosa. The gastric antrum and the duodenal bulb showed local discoloration that could not be rinsed off. The medical history indicated that bromazepam (6 mg had been used daily as a sleeping aid in the previous two years. The histopathological findings showed appearances of chemical gastritis. Within the lamina propria and on the epithelial surface there were granules. There was no foreign body reaction to these granules. Corpus mucosa showed a mild chronic gastritis. Conclusions If discoloration of the mucosa at endoscopy is seen, a careful drug history must be sought. This is the first case in literature that shows a chemical gastritis after bromazepam intake.

  17. Chemical gastritis after chronic bromazepam intake: a case report

    OpenAIRE

    Krakamp Bernd; Saers Thomas; Kirschberg Oliver; Brockmann Michael

    2010-01-01

    Abstract Background We describe a rare case of diffuse macroscopic discoloration and chemical gastritis due to chronic bromazepam intake. The chemical composition of pharmaceuticals has to be considered at endoscopy and it is evident that some chemical substances damage the epithelial tissue and lead to clinical symptoms. Case Presentation Endoscopy was performed in an 82-year-old patient due to gastroesophageal reflux symptoms and epigastric pain. Gastroscopy showed a hiatal hernia and a sca...

  18. Ultrastructural changes of gastric mucosa of rats with atrophic gastritis caused by hot water%热水致大鼠萎缩性胃炎胃黏膜超微结构变化

    Institute of Scientific and Technical Information of China (English)

    张沥; 张玲霞; 陶梅; 王春梅; 江梅; 杨家骥; 宋瑛

    2007-01-01

    Objective To observe the ultrastructural changes of gastric mucosa of rats with atrophic gastritis caused by hot water and investigate the pathogenesis of atrophic gastritis and the relationship between chronic atrophic gastritis (CAG) and hot diet. Methods The rat atrophic gastritis model was induced by gavage with hot water(55℃, 150g/mL, 2.5mL/d x 32 weeks). Histopathological methods were used to examine the selected gastric glands and antrum of rat. The ultrastructure of gastric mucosa were observed under scanning electromicroscope. Results (1) The optical microscope observation showed that the surface of the gastric mucosa was smooth and no erosion could be observed there in control group. There was no inflammatory infiltration in lamina propria. Nor was there edema in submucous layer or inflammatory infiltration in muscular layer. In hot water group, when hot water was given 24 weeks, the body of gastric gland of rat's gastric mucosa shrank obviously. The smooth muscle in muscular layer of mucosa had hyperplasia and got into the lamina propria of mucosa. The glandular epithelium in the up 1/3~2/3 part of the gland was atrophic. The lumen of the glards became broadened and the width of mucosa in the neck of gastric pit became narrowed. (2) The scanning electromicroscope observation showed that, in control group, the gastric mucosa was compartmentalized by crisscross grooves into many micro gastric areas, in the shape of reticulation. The epithelium was lined regularly and covered with laminar mucus. In hot water group, when hot water was given for 24 weeks, the gastric mucosa cells became atrophic. The lumen of gland was broadened and bleeding could be observed . When hot water was given for 32 weeks, besides the atrophic gastric mucosa and more broadened lumen of gland, much exfoliation of epithelium, the breakage of the cells and the focal erosion of mucosa were also found. (3) The transmission electromicroscope observation showed that the body of gland

  19. Histology of chronic gastritis with and without duodenitis in patients with Helicobacter pylori infection.

    OpenAIRE

    Phull, P S; Price, A. B.; Stephens, J; Rathbone, B J; Jacyna, M R

    1996-01-01

    AIM: To compare the histological characteristics of Helicobacter pylori positive chronic gastritis in patients with and without associated duodenitis. METHODS: Gastric mucosal biopsy specimens were obtained from patients undergoing endoscopy for dyspepsia. Severity of gastritis and density of H pylori infection were graded according to the Sydney system. RESULTS: Of the 69 patients studied, 15 had normal histology, 22 had chronic gastritis only (77.3% H pylori positive), 21 had duodenitis (90...

  20. Deep Learning Based Syndrome Diagnosis of Chronic Gastritis

    Directory of Open Access Journals (Sweden)

    Guo-Ping Liu

    2014-01-01

    Full Text Available In Traditional Chinese Medicine (TCM, most of the algorithms used to solve problems of syndrome diagnosis are superficial structure algorithms and not considering the cognitive perspective from the brain. However, in clinical practice, there is complex and nonlinear relationship between symptoms (signs and syndrome. So we employed deep leaning and multilabel learning to construct the syndrome diagnostic model for chronic gastritis (CG in TCM. The results showed that deep learning could improve the accuracy of syndrome recognition. Moreover, the studies will provide a reference for constructing syndrome diagnostic models and guide clinical practice.

  1. Deep Learning Based Syndrome Diagnosis of Chronic Gastritis

    Science.gov (United States)

    Liu, Guo-Ping; Wang, Yi-Qin; Zheng, Wu; Zhong, Tao; Lu, Xiong; Qian, Peng

    2014-01-01

    In Traditional Chinese Medicine (TCM), most of the algorithms used to solve problems of syndrome diagnosis are superficial structure algorithms and not considering the cognitive perspective from the brain. However, in clinical practice, there is complex and nonlinear relationship between symptoms (signs) and syndrome. So we employed deep leaning and multilabel learning to construct the syndrome diagnostic model for chronic gastritis (CG) in TCM. The results showed that deep learning could improve the accuracy of syndrome recognition. Moreover, the studies will provide a reference for constructing syndrome diagnostic models and guide clinical practice. PMID:24734118

  2. Study on the pathological basis of classification of spleen deficiency in chronic gastritis

    Institute of Scientific and Technical Information of China (English)

    尹光耀; 张武宁; 沈小静; 何雪芬; 陈一

    2004-01-01

    Background Spleen in Traditional Chinese Medicine (TCM) is not actually the spleen in the anatomic sense designated in western medicine because its functions basically belong to the physiological category of digestive system in modern medicine, and it represents a macroscopic concept of digestion, absorption and nutrition metabolism. Spleen deficiency syndrome refers to the clinical phenomena such as hypofunction of digestion, absorption and nutrition metabolism. By integrating TCM with modern medicine , this paper is intended to explore the pathological basis of classification of spleen deficiency in chronic gastritis.Method By means of optical microscope, scanning electron microscope (SEM), transmission electron microscope (TEM) and histochemical staining, we conducted histopathological and subcellular ultrastructural (nuclei and mitochondrial) analysis of gastric mucosa of 188 patients of spleen deficiency, and that of 42 voluntary blood donors without clinical symptoms. Results The gastric mucosa of patients with spleen Qi deficiency (SQD) and spleen yang deficiency (SyangD) could either be affected by organic lesion (type G-occurring on the basis of chronic superficial gastritis (CSG), chronic atrophic gastritis (CAG)) or unaffected (type F-chiefly belonging to functional indigestion); spleen yin deficiency (SyinD) and spleen deficiency with Qi stagnation (SDQS) both occurred on the basis of CSG and CAG; and the degree of mucosa inflammatory cells infiltration, the degree of decrease in glands propria, and the incidence of IMⅡb in CSG and CAG were more serious than those of G-SQD and G-SyangD, P<0.05-0.01.Conclusion Spleen deficiency syndrome is likely to occur on the basis of organic lesion of gastric mucosa (disease with symptoms of both CSG or CAG and spleen deficiency symptoms), as well as on the basis of inorganic lesion of gastric mucosa (nondisease with symptoms, which is, despite spleen deficiency symptoms, there is no CSG or CAG). Besides, the

  3. Study on the pathophysiologic basis of classification of 'spleen' deficiency in chronic gastritis

    Institute of Scientific and Technical Information of China (English)

    YIN Guang-yao; CHEN Yi; SHEN Xiao-jing; HE Xue-fen; ZHANG Wu-ning

    2005-01-01

    Background Most of the studies on traditional Chinese medicine (TCM)‘spleen’deficiency syndrome in the recent 30 years were conducted only on the basis of single functional index, neglecting the study on the pathophysiologic internal relationship between spleen deficiency syndrome and gastric diseases in modern medicine. But it was at the subcellular molecular biological level that we explored the pathophysiologic basis of classification of spleen deficiency in chronic gastritis by detecting the bioactive substances in gastric mucosa nuclei and mitochondria. Methods By means of optical microscope, scanning electron microscope (SEM), transmission electron microscopy (TEM) and histochemical staining, we conducted histopathological, subcellular ultrastructural analysis and nuclei and mitochondrial ultrastructural analysis of gastric mucosa of 188 spleen deficiency patients and of 42 voluntary blood donors. At the same time, bioactive substances were measured by means of X-ray energy dispersive analysis system (EDAX) image analysis system, radioimmunoassay method and chemiluminescence method. Results The content of cAMP, superoxide dismutase (SOD), Zn and Cu in gastric mucosa, and the content of Zn and Cu in mitochondria decreased progressively in order of groups: healthy control (HC), spleen Qi deficiency without organic lesion (F-SQD), spleen Yang deficiency without organic lesion (F-SyangD), disease without symptoms group, spleen Qi deficiency with organic lesion (G-SQD), spleen Yang deficiency with organic lesion (G-SyangD), spleen Yin deficiency (SyinD) and spleen deficiency with Qi stagnation (SDQS), chronic spleen deficiency gastritis (CSG) and chronic atrophic gastritis (CAG); decreased in order of HC, intestinal metaplasia (IM)Ⅰa, IMⅠb, IMⅡa and IMⅡb, P<0.05. The content of DNA, Zn and Cu in nuclei progressively increased in order mentioned above, P<0.05.Conclusions The quantitative changes of gastric mucosal cAMP, SOD, Zn, Cu, of mitochondrial Zn

  4. Correlation between myeloid-derived suppressor cells and gastric cancer begin with chronic gastritis

    Institute of Scientific and Technical Information of China (English)

    朱立宁

    2012-01-01

    Objective To investigate the correlation between the ratio change of circulating myeloid-derived suppressor cells(MDSCs) and cellular immune function in healthy volunteers,chronic gastritis patients,gastric intraepithelial neoplasia patients and gastric cancer patients

  5. Helicobacter pylori lipopolysaccharide:Biological activities in vitro and in vivo, pathological correlation to human chronic gastritis and peptic ulcer

    Institute of Scientific and Technical Information of China (English)

    Yi-Hui Luo; Jie Yan; Ya-Fei Mao

    2004-01-01

    AIM: To determine the biological activity of Helicobacter pylori (Hpylori) lipopolysaccharide (H-LPS) and understand pathological correlation between H-LPS and human chronic gastritis and peptic ulcer.METHODS: H-LPS of a clinical Hpylori strain and LPS of Escherichia coli strain O55:B5 (E-LPS) were extracted by phenol-water method. Biological activities of H-LPS and E-LPS were detected by limulus lysate assay, pyrogen assay,blood pressure test and PBMC induction test in rabbits,cytotoxicity test in NIH 3T3 fibroblast cells and lethality test in NIH mice. By using self-prepared rabbit anti-H-LPS serum as the first antibody and commercial HRP-labeled sheep anti-rabbit sera as the second antibody, H-LPS in biopsy specimens from 126 patients with chronic gastritis (68 cases) or gastric ulcer (58 cases) were examined by immunohistochemistry.RESULTS: Fibroblast cytotoxicity and mouse lethality of H-LPS were weaker than those of E-LPS. But the ability of coagulating limulus lysate of the two LPSs was similar (+/0.5 ng/mL). At 0.5 h after H-LPS injection, the blood pressures of the 3 rabbits rapidly declined. At 1.0 h after H-LPS injection, the blood pressures in 2 of the 3 rabbits fell to zero causing death of the 2 animals. For the other one rabbit in the same group, its blood pressure gradually elevated. At 0.5 h after E-LPS injection, the blood pressures of the three rabbits also quickly declined and then maintained at low level for approximately 1.0 h. At 0.5 h after injection with H-LPS or E-LPS, PBMC numbers of the rabbits showed a remarkable increase. The total positivity rate of H-LPS from 126 biopsy specimens was 60.3%(76/126). H-LPS positivity rate in the biopsy specimens from chronic gastritis (50/68, 73.5%) was significantly higher than that from gastric ulcer (26/58, 44.8%) (X2=10.77,P<0.01). H-LPS positivity rates in biopsy specimens from chronic superficial gastritis (38/48, 79.2%) and chronic active gastritis (9/10, 90.0%) were significantly higher than

  6. A histopathologic analysis of chronic inflammatory infiltrate in patients of h. pylori associated chronic gastritis

    International Nuclear Information System (INIS)

    To determine the relationship between H. pylori density with severity of chronic inflammatory infiltrate. Study Design: A cross-sectional study. Place and Duration of Study: The study was carried out in the Department of Pathology (Histopathology), Army Medical College, National University of Sciences and Technology (NUST) Islamabad, from Nov 2011 to Nov 2012. Methodology: Gastric antral biopsies of H. pylori associated chronic gastritis were included in the study. Demographic characteristics and relevant clinical information were collected. First hundred biopsies of H. pylori associated chronic gastritis were assessed for density of H. pylori and chronic inflammatory infiltrate. istopathological features like lymphoid aggregates, ulcer slough, superficial epithelial damage, dysplasia and nuclear reactive changes were simply assessed in case of their presence or absence. Results: A significant moderate positive correlation was found between grades of H. pylori and chronic inflammatory infiltrate (rs= 0.636). Insignificant correlation was found with lymphoid aggregates, superficial epithelial damage, dysplasia and nuclear reactive changes. Conclusion: In conclusion this study corroborated the determination of histopathological parameters and depicted that, the greater the density of H. pylori infection, the greater the degrees of chronic inflammatory infiltrate. (author)

  7. Treatment of Chronic Gastritis by Acupuncture: A Review

    Institute of Scientific and Technical Information of China (English)

    HUANG Qin-feng; QI Li-zhen; XIAO Yuan-chun

    2005-01-01

    从<中国现代针灸信息数据库(1970~2002年)收录的40398条信息进行分析,收集93篇针灸治疗胃炎论文,涉及5325例病例中分析,总有效率为94.4%.常采用针刺,灸法,埋藏疗法,水针.常用穴为足三里,中脘,胃俞,脾俞,内关,肝俞,三阴交等,胃痛甚者加梁丘和公孙;腹胀加天枢和气海;腹泻加天枢和上巨虚;呕吐加上脘和太冲.%This paper collects and analyzes 40 398 pieces of information from Chinese Modern Acupuncture Information Database (1970- 2002). It covers 93 articles concerning the treatment of chronic gastritis by acupuncture and 5 325 subjects, the total effective rate being 94.4%. The frequent treatment methods are needling, moxibustion, burial therapy, and hydropuncture. The major acupoints are Zusanli (ST 36), Zhongwan (CV 12), Weishu (BL 21),Pishu (BL20), Neiguan (PC 6), Ganshu (BL 18), Sanyinjiao (SP 6), etc. In the presence of severe stomachache, Liangqiu (ST 34) and Gongsun (SP 4) are added; in the presence of abdominal fullness, Tianshu (ST 25) and Qihai (CV 6) are added; in the presence of diarrhea, Tianshu (ST 25) and Shangjuxu (ST 37) are added; in the presence of vomiting, Shangwan (CV 13) and Taichong (LR 3) are added.

  8. Professor Jiang Liangduo ’s Theory of Treating Atrophic Gastritis from “State”%姜良铎教授“从态论治”萎缩性胃炎的思想研究

    Institute of Scientific and Technical Information of China (English)

    王春勇; 史成和; 邢殿文; 康雷

    2015-01-01

    The experience of professor Jiang Liangduo in treating atrophic gastritis from the “state”was summarized in order to ex-plore this treating method,namely,under a macro perspective,the modern biological-psychological-social medical mode is adopted and under a micro perspective,combined with the modern understanding of atrophic gastritis,the diagnosis process focuses on both the microscopic state of stomach and the macro state of related zang-fu organs,triple energizer and qi and blood.The treating prin-ciples mainly based on the regulating of triple energizer.A holistic perspective should be adopted to grasp the general state of psy-chology,behavior and other factors to simplify and optimize the treatment of atrophic gastritis.%总结姜良铎教授从态论治萎缩性胃炎经验,论述从态论治萎缩性胃炎的思想内涵,即:针对萎缩性胃炎,宏观上采用当代的生物-心理-社会医学模式,微观上结合现代科学对萎缩性胃炎的最新认识,辨证时既要着眼于胃腑详细的微观状态,又要关注相关脏腑、三焦、气血宏观状态,立法以通调三焦为大法,治疗时整体把握,结合心理、行为等方法多因素干预,使复杂的萎缩性胃炎得以合理有效的治疗。

  9. Cirurgia laparoscópica no diagnóstico de gastrite crônica atrófica seguida de tratamento clínico em cadela: relato de caso Laparoscopic surgery in the diagnosis of atrophic gastritis in a dog followed by clinical treatment: case report

    Directory of Open Access Journals (Sweden)

    P.C. Basso

    2007-10-01

    Full Text Available Descrevem-se o diagnóstico e o tratamento de um caso de gastrite atrófica crônica, em uma cadela sem raça definida, de dois anos de idade. A paciente apresentava como principal sintomatologia vômito crônico. O hemograma, a urinálise e as avaliações bioquímicas séricas não revelaram alterações significativas. Os exames radiológicos e ultra-sonográficos abdominais também não foram sugestivos de alterações. Realizaram-se inspeção da cavidade peritoneal, gastrotomia, gastroscopia, gastrectomia para biopsia e gastrorrafia intracorpórea videolaparoscópicas. Constatou-se ausência de rugosidades estomacais. Ao exame histológico, observou-se atrofia das células principais e parietais da mucosa gástrica. O quadro clínico permitiu o diagnóstico de gastrite crônica atrófica. O animal foi medicado com terapia imunossupressora e apresentou remissão completa dos sinais clínicos.This report describes a case of chronic atrophic gastritis. A two-year-old female mongrel dog showed chronic emesis. The complete blood count serum chemistry and urinalysis values were within the normal limits. Radiographs revealed no alterations. Abdominal evaluation, gastrotomy, gastroscopy, gastrectomy and intracorporeal stomach suture were done by laparoscopic approach. Absence of gastric villous was noticed through laparoscopic biopsy. The microscopic analysis reveled parietal and principal gastric mucosal cells atrophy, which, associated with clinical signs, allowed the chronic atrophic gastritis diagnosis. The animal was treated and clinical signs complete remission was observed.

  10. Study of the efficiency use of physical rehabilitation in patients with chronic gastritis

    Directory of Open Access Journals (Sweden)

    Kalmykov S.A.

    2014-05-01

    Full Text Available Purpose: to make physical rehabilitation program for patients with chronic gastritis type B, promotes normalization of gastric secretory function and prolong the period of remission. Objectives of the study was to assess the dynamics of gastric secretory function and functional status of the autonomic nervous system in patients with the chronic gastritis type B . Material: the study involved 37 women with a diagnosis of the chronic gastritis type B, increased acid gastric function. Results: it was established the positive influence of corrective exercises for the lower thoracic and lumbar spine, regulated breathing exercises based on the tone of the autonomic nervous system in combination with massage and diet therapy on the state of gastric secretory function. Conclusions : it is recommended to carry out therapeutic physical culture in the form of morning hygienic gymnastics, therapeutic exercises, self-study.

  11. The relationship between helicobacter pylori infection with chronic gastritis and peptic ulcer%幽门螺杆菌感染与慢性胃炎和消化性溃疡的关系

    Institute of Scientific and Technical Information of China (English)

    赵荣章

    2015-01-01

    目的:探讨幽门螺杆菌(Hp)感染与慢性胃炎、消化性溃疡的关系。方法:收治胃镜检查确诊的慢性胃炎、消化性溃疡患者151例,包括慢性浅表性胃炎、慢性糜烂性胃炎、慢性萎缩性胃炎、胆汁反流性胃炎以及胃和十二指肠溃疡,分别给予胃黏膜组织活检及快速尿素酶试验检查Hp感染情况,分析炎性反应情况与Hp感染的关系。结果:慢性萎缩性胃炎37例,Hp感染阳性率86.48%;慢性糜烂性胃炎36例,Hp感染阳性率80.56%;慢性浅表性胃炎26例,Hp感染阳性率65.38%;胆汁反流性胃炎22例,Hp感染阳性率36.36%,消化性溃疡30例,Hp感染阳性率80.00%。慢性萎缩性胃炎阳性率最高,胆汁反流性胃炎阳性率最低,差异具有统计学意义(P<0.05)。结论:几种常见的慢性胃炎、消化性溃疡均伴有不同程度Hp的感染,不同胃炎、消化性溃疡中Hp感染率差异具有统计学意义。慢性糜烂性胃炎、慢性萎缩性胃炎以及消化性溃疡感染Hp明显高于正常人群,从而提出Hp感染是产生的重要致病因素。%Objective:To investigate the relationship between helicobacter pylori(Hp) infection with chronic gastritis and peptic ulcer.Methods:151 patients with chronic gastritis or peptic ulcer were selected,including chronic superficial gastritis,chronic erosive gastritis,chronic atrophic gastritis,bile reflux gastritis,gastric and duodenal ulcer.All of those patients were treated with gastric mucosal biopsy and rapid urease test to detected helicobacter pylori infection,then we analyzed the relationship between inflammatory response and Hp infection.Results:37 cases were with chronic atrophic gastritis,and the positive rate of Hp infection was 86.48%;36 cases were chronic erosive gastritis,and the positive rate was 80.56%;26 cases were chronic superficial gastritis, and the positive rate was 65.38%;22 cases were bile reflux gastritis,and the positive rate

  12. [The use of the multivitamin preparation Supradin in treating patients with chronic gastritis and peptic ulcer].

    Science.gov (United States)

    Novoderzhkina, Iu G; Cherentsov, A M

    1992-08-01

    The content of ascorbin acid and thiamin was assessed in the food ration of 36 patients with chronic gastritis and ulcer disease. By the end treatment including dietotherapy these vitamins showed a deficit. Correction of this deficit of the above mentioned vitamins with a polyvitamine drug "Supradin" allowed to improve significantly the biochemical indices and availability of ascorbic acid and thiamin in patients with chronic gastritis and ulcer disease. The treatment produced a favourable effect on the clinical course of the disease, reduction of the pain syndrome and earlier recovery. PMID:1475934

  13. Introduction to Dr. ZHAO Guo-cen's Experience in Treating Chronic Atrophic Gastritis

    Institute of Scientific and Technical Information of China (English)

    ZHAO Yi; YU Yue-juan; XIAO Yuan-chun

    2005-01-01

    @@ ZHAO Guo-cen, a senior doctor born in 1937, is a member of China Association of Traditional Chinese Medicine and one of the 500 well-known supervisors qualified to instruct disciples. He was born into a Chinese medicine family and has been engaging himself in the treatment of digestive disorders. He is an expert at internal medicine and acupuncture. His main clinical experience is summarized as "Nourishing spleen and stomach to treat digestive disorders, nourishing spleen and kidneys to treat diabetes mellitus, supplementing heart-qi and activating stagnated blood to treat chest distress, and restoring kidney-qi and balancing yin and yang to treat infertility."

  14. Therapeutic effect of Streptococcus thermophilus CRL 1190-fermented milk on chronic gastritis

    Institute of Scientific and Technical Information of China (English)

    Cecilia; Rodríguez; Marta; Medici; Fernanda; Mozzi; Graciela; Font; de; Valdez

    2010-01-01

    AIM: To investigate the potential therapeutic effect of exopolysaccharide (EPS)-producing Streptococcus thermophilus (S. thermophilus) CRL 1190 fermented milk on chronic gastritis in Balb/c mice. METHODS: Balb/c mice were fed with the fermented milk for 7 d after inducing gastritis with acetyl-salicylic acid (ASA, 400 mg/kg body weight per day for 10 d). Omeprazole was included in this study as a positive therapeutic control. The gastric in? ammatory activity was evaluated from gastric histology and in? amm...

  15. 克拉霉素联合甲硝唑及叶酸治疗萎缩性胃炎临床分析%Clinical Analysis of Clarithromycin Combined With Metronidazole and Folic Acid in Treatment of Atrophic Gastritis

    Institute of Scientific and Technical Information of China (English)

    于恩媛

    2015-01-01

    Objective Clinical treatment efficacy of clarithromycin combined with metronidazole and folic acid in treatment of atrophic gastritis is to be analyzed. Methods Chose 38 atrophic gastritis patients who were treated in hospital from August 2013 to September 2014 and separated them into two groups according to different treatment methods,19 patients in study group were given clarithromycin combined with metronidazole and folic acid treatment; while 19 patients in control group were given amoxicillin combined with metronidazole and folic acid treatment; and then observed and compared treatment efficacy in these two groups. Results Compared to control group,the treatment efficacy in study group was much higher and the side-effect incidence in study group was much less than control group,there was differential between study group and control group and such a differential had statistic value(P<0.05). Conclusion Clarithromycin combined with metronidazole and folic acid is of efficacy in clinical treatment of atrophic gastritis; thus,it is quite worthwhile to be promoted and applied clinically.%目的:分析克拉霉素联合甲硝唑及叶酸对萎缩性胃炎的临床治疗效果。方法搜集2013年8月~2014年9月我院接收的萎缩性胃炎38例患者,按照治疗方法不同进行分组。实验组19例,给予克拉霉素联合甲硝唑及叶酸;对照组19例,给予阿莫西林联合甲硝唑及叶酸。观察两组疗效,对比分析。结果与对照组相比,实验组治疗有效率较高,不良反应的发生率较低,差异有统计学意义(P<0.05)。结论克拉霉素联合甲硝唑及叶酸对萎缩性胃炎的临床治疗效果较好。

  16. Postprandial fullness correlates with rapid inflow of gastric content into duodenum but not with chronic gastritis

    Directory of Open Access Journals (Sweden)

    Yamamichi Nobutake

    2011-12-01

    Full Text Available Abstract Background The aim of this study is evaluating the correlation of postprandial fullness with chronic gastritis or rapid inflow of gastric content into duodenum, based on double-contrast barium X-ray imaging. Methods 253 healthy subjects who underwent upper gastrointestinal barium X-ray examination were analyzed. Chronic gastritis was judged from mucosal atrophy and hypertrophic thickened folds on barium X-ray images. For the gastric excretion, the tips of barium flow on the single-contrast frontal barium X-ray images of the stomach were classified into four categories; V type (all the barium remained in the stomach, V-H type (some barium had flowed into the duodenum but the tip of barium remained in the proximal half of the duodenal bulb, H-V type (some barium had flowed into the duodenum and the tip of barium was in the distal half of duodenal the bulb, but no barium was observed in the descending part of the duodenum, and H type (some barium had flowed into the descending part of the duodenum. The chi-square test and Cochran-Mantel-Haenzel test were used for evaluation. Results Chronic gastritis was observed in 72 subjects, among which 21 subjects (29.2% presented with postprandial fullness. For the remaining 181 subjects without chronic gastritis, 53 subjects (29.3% complained of postprandial fullness. There is no significant correlation between chronic gastritis and postprandial fullness (p = 0.973. For the rapid flow of gastric content into duodenum, all the 253 subjects comprised 136 subjects with V type (in the stomach, 40 subjects with V-H type (in the proximal half of the duodenal bulb, 21 subjects with H-V type (in the distal half of the duodenal bulb, and 56 subjects with H type (in the descending part of the duodenum. Postprandial fullness was present in 30 subjects with V type (22.1%, 9 subjects with V-H type (22.5%, 8 subjects with H-V type (38.1%, and 27 subjects with H type (48.2%. There is a distinct correlation between

  17. Homocysteine Levels in Chronic Gastritis and Other Conditions: Relations to Incident Cardiovascular Disease and Dementia

    OpenAIRE

    Redéen, Stefan; Ryberg, Anna; Petersson, Fredrik; Eriksson, Olle; Nägga, Katarina; Borch, Kurt

    2009-01-01

    Background Homocysteine levels in circulation are determined by several factors and hyperhomocysteinemia is reportedly associated with cardiovascular diseases and dementia. The aim of this study is to determine the relation of chronic gastritis and other conditions to homocysteine levels and their relation to incident cardiovascular diseases and dementia. Methods An adult population-based cohort (N = 488) was screened for H. pylori infection, gastro-duodenitis (endoscopic biopsies), disease h...

  18. Preventive effect of cimetidine on chronic erosive gastritis induced by taurocholate in rats.

    Science.gov (United States)

    Kishimoto, S; Kobuke, K; Kobayashi, H; Kajiyama, G; Miyoshi, A; Daitoku, K

    1991-01-01

    We studied the preventive effect of cimetidine at the microscopic level on chronic erosive gastritis induced experimentally by 6-months of administration of drinking water containing 5 mmol/l of the sodium salt of taurocholic acid (TCA) in rats. The chronic erosive gastritis was characterized by mucosal erosions, reduction of mucosal thickness and reduction in the number of parietal cells per unit area, infiltration of inflammatory cells which were mainly lymphocytes and plasmocytes, and proliferation of collagenous fibers in the gastric mucosa. A standard meal including cimetidine 0.4 and 0.8%, which was administered ad libitum with TCA, reduced the total length of erosions, normalized the mucosal thickness and the number of parietal cells, and reduced inflammatory cell infiltration in the gastric mucosa. However, cimetidine did not show any effect on the proliferation of collagenous fibers in the interstitial space of the mucosa. The doses administered were 400 mg/kg/day and 800 mg/kg/day for 6 months. Cimetidine, thus, had a preventive effect on experimental chronic erosive gastritis in rats. PMID:2024066

  19. Helicobacter pylori and gastritis: the role of extracellular matrix metalloproteases, their inhibitors, and the disintegrins and metalloproteases--a systematic literature review.

    Science.gov (United States)

    Sampieri, Clara L

    2013-10-01

    Helicobacter pylori (H. pylori) is the etiologic agent of gastritis; it has been estimated that 50 % of the world's population could be infected by this bacteria. Gastritis may progress to chronic atrophic gastritis, a condition associated with the development of gastric cancer (GC). Several matrix metalloproteases (MMP) and tissue inhibitors of MMPs (TIMP) as well as disintegrins and metalloproteases (ADAM) have been reported as being involved in gastritis. Among other processes, these protein families participate in remodeling the extracellular matrix, cell signaling, immune response, angiogenesis, inflammation and epithelial mesenchymal transition. This systematic review analyzes the scientific evidence surrounding the relationship between members of the MMP, TIMP and ADAM families and infection by H. pylori in gastritis, considering both in vitro and in vivo studies. Given the potential clinical value of certain members of the MMP, TIMP and ADAM families as molecular markers in gastritis and the association of gastritis with GC, the need for further study is highlighted.

  20. Helicobacter pylori detection in chronic gastritis: a comparison of staining methods

    International Nuclear Information System (INIS)

    Background: Helicobacter pylori is an important cause of chronic gastritis, gastric ulceration and gastric malignancies as gastric carcinoma and MALT lymphoma. Its definitive diagnosis is based on histopathology. Routine H and E stain is not very effective in its detection, immune-stains and fluorescent stains are costly. Need for simple cheap and sensitive stain has always been a topic of hot debate and extensive research. Method: paraffin embedded blocks of all adult patients diagnosed as chronic gastritis/gastric ulceration with no accompanying gastric pathology as hypertrophic gastropathys, and neoplasias were taken into study. Three sections of 4 micron were cut and stained with routine H and E, Giemsa, and Cresyl fast violet. Results: Total number of patients was 50. Out of these 37 (74%) were males and 13 (26%) were females. Mean age of the patients was 50.4 years. Thirty-four percent (34%) were positive in normal H and E stain, 68% were positive in Giemsa and 76% were positive in Cresyl fast violet. Conclusion: Cresyl fast violet is a good stain for diagnosis of H. pylori gastritis. (author)

  1. Systematic Evaluation of Therapeutic Effect of Acupuncture Treatment on Chronic Gastritis%针刺治疗慢性胃炎有效性的系统评价

    Institute of Scientific and Technical Information of China (English)

    陈璐; 李素荷

    2013-01-01

    Abstract:Objective:To assess the therapeutic effect and safety of acupuncture on chronic gastritis.Methods:Electronic searches of PubMed,the Cochrane Library,EMBASE,of Medline,CNKI and VIP database,manual searches of Guangzhou University of Traditional Chinese Medicine Library journal database,based on the inclusion and exclusion criteria,screening the inclusion criteria of randomized controlled trials of acupuncture treatment for chronic gastritis,handbook using the Cochrane reviews 5.0 of the literature to evaluate the quality,efficacy was evaluated by using the Review Manage 5.1 software Meta-analysis.Results:Ultimately included 13 studies,and 946 patients were included.The evaluation found that after the risk of bias assessment and documentation quality,the inclusion in the literature there was a high risk of bias and included in the literature,low quality.Meta-analysis results showed that:①For the treatment of chronic gastritis from the total effective rate in terms of OR =3.89,95 % CI [2.64,5.74],Z =6.86,P < 0.0001,the difference was statistically significant,suggesting that acupuncture therapy could improve the total efficiency of chronic gastritis,and the acupuncture group was better than the WM group; ②For the treatment of chronic atrophic gastritis,the total efficiency in terms of OR =4.24,95 % CI was [2.54,7.09],Z =5.51,P < 0.0001,the difference was statistically significant,suggesting that acupuncture could improve chronic atrophic gastritis,and the total effective rate in the acupuncture group was better than that in the western medicine group; ③For chronic gastritis from the Hp clearance rate point of view,OR =1.03,95 % CI [0.42,2.51],Z =0.06,P =0.95 > 0.05,the difference was not statistically significant,suggesting that there was an insufficient evidence to prove that the acupuncture group had a better Hp clearance rate than that in the western medicine group.Conclusion:Acupuncture,as a safe and effective treatment,is suitable for

  2. Collagenous Gastritis

    OpenAIRE

    Hugh J Freeman; Piercy, James R.A.; Raine, Robert J.

    1989-01-01

    A 54-year-old woman presented with nausea, vomiting and weight loss associated with impaired gastric emptying necessitating institution of parenteral nutrition. Subsequent studies revealed an unusual gastric mucosa! inflammatory process characterized by unique subepithelial collagenous deposits. Collagenous gastritis appears to be a distinct, possibly immune-mediated, chronic disorder, pathologically reminiscent of collagenous sprue and collagenous colitis.

  3. 萎缩性胃炎脾气虚证免疫小分子蛋白组表达的研究%Study on Atrophic Gastritis in Immunity Micromolecule Proteome of Spleen-qi Deficiency

    Institute of Scientific and Technical Information of China (English)

    时小红; 徐珊

    2012-01-01

    [Objective] Atrophic gastritis is a disease with intestinal metaplasia, and reveals that human immune system (cells, body fluids, partial immunity) is in a low state. "Spleen is a defense banier to pathogenic qi," "if spleen function maintains normal all the time, human body will not be ill," that reveals the immune role of the spleen. In modern medicine, spleen is regarded as immune response and immune material base, one of the barriers of the human immune system. Because proteomics is not anatomical concept of organs and tissues etc., but involves in certain aspects' alteration in biochemistry and internal relationship of disease processes. These physiological and pathological viewpoints are in coincident with TCM holism. From the angle of immunity micro-molecule proteome, atrophic gastritis spleen-qi deficiency substance will be elaborated.%萎缩性胃炎(AG)是人体整体免疫力(细胞、体液、局部免疫)低下,多种因素长期作用而表现胃局部、常伴肠化的病症.“脾为之卫”、“四季脾旺不受邪”,表现脾的免疫防卫作用,现代医学也认为脾是免疫应答和产生免疫效应物质的重要基地,人体免疫系统的屏障之一.由于蛋白质组学的研究不是从器官组织的解剖学定位出发,强调生物化学某一环节的改变和疾病过程的内在联系,与中医学整体的生理病理观有更多的切合点,本文旨在从免疫小分子蛋白质组表达规律的角度观察与AG脾气虚证的相关性.

  4. Medicinal Herbs Used in Pairs for Treatment of 98 Cases of Chronic Gastritis

    Institute of Scientific and Technical Information of China (English)

    夏建忠

    2004-01-01

    Objective: Chronic gastritis was treated with herbal pairs in order to reduce the side effects and raise the therapeutic effects. Method: The outpatients were randomly divided into a treatment group treated with herbal pairs and a control group treated with Banxia Xiexin Tang (Pinellia Decoction for Purging the Stomach-fire). Result: The total effective rate in the treatment group was 96%, higher than that in the control group (P<0.05). Conclusion: With the basic theory of traditional Chinese medicine as guiding principles, herbal pairs have two-way regulatory effects, that is, reducing the side effects and raising the therapeutic effects.

  5. The Metabonomic Studies of Tongue Coating in H. pylori Positive Chronic Gastritis Patients

    Directory of Open Access Journals (Sweden)

    Xuan Liu

    2015-01-01

    Full Text Available In Traditional Chinese Medicine (TCM, tongue diagnosis (TD has been an important diagnostic method for the last 3000 years. Tongue coating can be used as a very sensitive marker to determine the progress of chronic gastritis. Therefore, the scientific, qualitative, and quantitative study for the pathophysiologic basis of tongue coating (TC emerged as a major direction for the objective research of TD. In our current report, we used GC/MS technology to determine the potential changes of metabolites and identify special metabolic biomarkers in the TC of H. pylori infected chronic gastritis patients. Four discriminative metabolites were identified by GC/MS between the TC of H. pylori infection (G+H and without H. pylori infection (G-H patients: ethylene, cephaloridine, γ-aminobutyric acid, and 5-pyroglutamic acid, indicating that changes in amino acid metabolism are possibly involved in the formation of TC, and the amino acid metabolites are part of the material components of TC in G+H patients.

  6. Effects of bile reflux on gastric mucosal lesions in patients with dyspepsia or chronic gastritis

    Institute of Scientific and Technical Information of China (English)

    Sheng-Liang Chen; Jian-Zhong Mo; Zhi-Jun Cao; Xiao-Yu Chen; Shu-Dong Xiao

    2005-01-01

    AIM: To investigate the influences of bile reflux on profiles of gastric mucosal lesions in patients with dyspepsia or chronic gastritis.METHODS: A total of 49 patients diagnosed with dyspepsia and chronic gastritis underwent 24-h ambulatory andsimultaneous monitoring of intragastric bilirubin absorbance and pH values, and then they were divided into bile refluxpositive group and bile reflux negative group. Severity of pathological changes in gastric mucosa including activeinflammation, chronic inflammation, intestinal metaplasia, atrophy and dysplasia as well as Helicobacter pylori (H pylori) infection at the corpus, incisura and antrum were determined respectively according to update Sydney system criteria. The profiles of gastric mucosal lesions in the two groups were compared, and correlations between time-percentage of gastric bilirubin absorbance >0.14 and severity of gastric mucosal lesions as well as time-percentage of gastric pH >4 were analyzed respectively. RESULTS: Thirty-eight patients (21 men and 17 women, mean age 44.2 years, range 25-61 years) were found existing with bile reflux (gastric bilirubin absorbance >0.14) and 11 patients (7 men and 4 women, mean age 46.2 years,range 29-54 years) were bile reflux negative. In dyspepsia patients with bile reflux, the mucosal lesions such as active inflammation, chronic inflammation, intestinal metaplasia, atrophy or H pylori infection in the whole stomach, especially in the corpus and incisura, were significantly more severe than those in dyspepsia patients without bile reflux. Moreover, the bile reflux time was well correlated with the severity of pathological changes of gastric mucosa as well as H pylori colonization in the near-end stomach, especially in the corpus region. No relevance was found between the time of bile reflux and pH >4 in gastric cavity. CONCLUSION: Bile reflux contributes a lot to mucosal lesions in the whole stomach, may facilitate H pylori colonization in the corpus region

  7. Role of the HLA-DQ locus in the development of chronic gastritis and gastric carcinoma in Mexican patients

    Institute of Scientific and Technical Information of China (English)

    Roberto Herrera-Goepfert; Jesús K Yamamoto-Furusho; Luis F O(n)ate-Oca(n)a; Margarita Camorlinga-Ponce; Leopoldo Mu(n)oz; Jorge A Ruiz-Morales; Gilberto Vargas-Alarcón; Julio Granados

    2006-01-01

    AIM: To determine the HLA-DQ locus in Mexican patients with Chronic gastritis and gastric adenocarcinoma.METHODS: Oligotyping for HLA-DQ locus was performed in 45 Mexican patients with chronic gastritis and 13 Mexican patients with diffuse-type gastric adenocarcinoma, and was then compared with 99 clinically healthy unrelated individuals. H pylori infection and CagA status were assessed in patients by enzyme-linked immunosorbent assay (ELISA) method.RESULTS: We found a significant increased frequency of HLA-DQB1*0401 allele in H pylori-positive patients with chronic gastritis when compared with healthy subjects [19 vs 0%, P = 1 × 10-7, odds ratio (OR) = 4.96; 95%confidence interval (95% CI), 3.87-6.35]. We also found a significant increased frequency of HLA-DQB1*0501 in patients with diffuse-type gastric carcinoma in comparison with healthy individuals (P = 1 × 10-6, OR = 13.07;95% CI, 2.82-85.14).CONCLUSION: HLA-DQ locus may play a different role in the development of H pylori-related chronic gastritis and diffuse-type gastric adenocarcinoma in the Mexican Mestizo population.

  8. Assay of gastrin and somatostatin in gastric antrum tissues of children with chronic gastritis and duodenal ulcer

    Institute of Scientific and Technical Information of China (English)

    Xiao-Zhi Xie; Zhi-Guang Zhao; Dan-Si Qi; Zong-Min Wang

    2006-01-01

    AIM: To study the expressions of gastrin (GAS) and somatostatin (SS) in gastric antrum tissues of children with chronic gastritis and duodenal ulcer and their role in pathogenic mechanism.METHODS: Specimens of gastric antrum mucosa from 83 children were retrospectively analyzed. Expressions of GAS and SS in gastric antrum tissues were assayed by the immunohistochemical En Vision method.RESULTS: The expressions of GAS in chronic gastritis Hp+ group (group A), chronic gastritis Hp- group (group B), the duodenal ulcer Hp+group (group C), duodenal ulcer Hp- group (group D), and normal control group (group E) were 28.50+4.55, 19.60+2.49, 22.69+2.71,25.33 + 4.76, and 18.80 + 2.36, respectively. The value in groups A-D was higher than that in group E. The difference was not statistically significant. The expressions of SS in groups A-E were 15.47 + 1.44, 17.29 + 2.04,15.30 + 1.38, 13.11 + 0.93 and 12.14 + 1.68, respectively.The value in groups A-D was higher than that in group E.The difference was also not statistically significant.CONCLUSION: The expressions of GAS and SS are increased in children with chronic gastritis and duodenal ulcer.

  9. Gene expression of ornithine decarboxylase, cyclooxygenase-2, and gastrin in atrophic gastric mucosa infected with Helicobacter pylori before and after eradication therapy.

    Science.gov (United States)

    Konturek, Peter C; Rembiasz, Kazimierz; Konturek, Stanislaw J; Stachura, Jerzy; Bielanski, Wladyslaw; Galuschka, K; Karcz, Danuta; Hahn, Eckhart G

    2003-01-01

    H. pylori (Hp) -induced atrophic gastritis is a well-known risk factor for the development of gastric cancer. Whether Hp eradication can prevent or retard the progress of atrophy and metaplasia has been the topic of numerous studies but the subject remains controversial. Recently, the increased expression of ornithine decarboxylase (ODC), gastrin and cyclooxygenase (COX)-2 has been shown to be increased in premalignant lesions in gastric mucosa and to play an essential role in the malignant transformation. The aim of the study is to assess the effect of eradication therapy on atrophic gastritis and analyze the gene expression for ODC, COX-2 and gastrin in gastric mucosa after succesful eradication in patients with atrophic gastritis. Twenty patients with chronic atrophic gastritis including both corpus and antrum of the stomach were included in this study. Four antral mucosal biopsy specimens were obtained from antrum and four from corpus. The histopathologic evaluation of gastritis was based on Sydney classification of gastritis. All patients were Hp positive based on the [13C] urea breath test (UBT) and the presence of anti-Hp IgG and anti-CagA-antibodies detected by ELISA. The patients were then eradicated with triple therapy consiting of omeprazol (2 x 20 mg), amoxycillin (2 x 1 g) and clarithromycin (2 x 500 mg) for seven days and vitamin C 1 g/day for three months. In gastric mucosal samples obtained from the antrum and corpus before and after eradication, the mRNA expression for ODC, COX-2, and gastrin was assessed by reverse-transcription polymerase chain reaction (RT-PCR). In all patients the gastric secretory analysis was performed by measuring gastric acid output and serum gastrin levels. After triple therapy the successful eradication assessed by UBT was observed in 95% of patients. In 45% of patients the infection with CagA-positive Hp strain was observed. Three months after eradication a significant reduction in the gastric activity (neutrophilic

  10. Interobserver consistency in histopathological assessment of chronic gastritis%慢性胃炎病理诊断的一致性研究

    Institute of Scientific and Technical Information of China (English)

    李新军; 付丽梅; 刘敏; 舒向芳; 李柏成; 郎志强; 李丽霞; 成建新; 常翠红

    2014-01-01

    目的 探讨采取慢性胃炎病理诊断标准培训并应用直观模拟评分法能否提高病理医师间慢性胃炎病理诊断的一致性.方法 8位病理医师对70份慢性萎缩性胃炎病理切片进行两轮读片,第一轮结束后接受《中国慢性胃炎共识意见(2012,上海)》中关于慢性胃炎病理诊断标准的培训,并在第二轮读片过程中运用直观模拟评分法.8位病理医师按工作年限和所在医院进行分组,采用Kappa分析两轮读片的慢性胃炎5项组织学改变诊断的一致性,并行对比分析.结果 8位病理医师第二轮读片对慢性胃炎5项组织学改变的总体诊断Kappa值均较第一轮读片有所提高,且5项组织学改变诊断的一致性程度也均有所提高.第二轮读片,高年资组和低年资组5项组织学改变的诊断Kappa值值差在-0.018 0~0.034 1,但5项组织学改变诊断的一致性程度均相同;同一医院组和不同医院组5项组织学改变的诊断Kappa值值差在0.0122~0.0497,其中幽门螺杆菌感染的诊断一致性程度好于不同医院组,其他4项组织学改变诊断的一致性程度均与不同医院组相同.结论 对病理医师进行《中国慢性胃炎共识意见(2012,上海)》中关于慢性胃炎病理诊断标准培训,并在读片时采用直观模拟评分法,可普遍提高病理医师间慢性胃炎病理诊断的一致性.%Objective To study the improvement of interobserver consistency in pathological diagnosis of chronic gastritis by using a visual-analog scale after the training on diagnostic criteria of chronic gastritis.Methods Eight pathologists conducted two rounds of evaluation of 70 slides with confirmed diagnosis of chronic atrophic gastritis.After the first round,every pathologist was trained with the diagnosis criteria from "Chinese consensus on chronic gastritis (2012,Shanghai)",and the visual analog scale was used in the second round.Eight pathologists were grouped by working experience and

  11. Impact on Gastric Mucosa Histopathology of Atrophic Gastritis by Traditional Chinese Drug Prescription Based on Asthenia Syndrome Depression Syndrome Poison Syndrome Static Blood Syndrome%从虚郁毒瘀立法组方对萎缩性胃炎鼠模型胃黏膜病理的影响

    Institute of Scientific and Technical Information of China (English)

    王常松; 王启国; 俞杰; 闵莉; 吴银盘

    2011-01-01

    Objective: To observe intervention of the traditional Chinese drug prescription based on asthenia syndrome, depression syndrome, poison syndrome, static blood syndrome on gastric mucosa histopathology, of atrophic gastritis.Methods: Alcohol, deoxysodium cholate, ammonia solution, indometacin and disorder between feeding and fasting were used to build the mode]of atrophic gastritis, which were treated respectively by the high-dose, mid-dose, low-dos traditional Chinese drug prescription based on asthenia syndrome, depression syndrome, poison syndrome, static Blood syndrome, and their therapeutic effects were appreciated by the degree of gastric mucosa inflammation and atrophy, thickness of gastric mucosa.Results: The degree of gastric mucosa inflammation and atrophy, thickness of gastric mucosa became better by means of the model of atrophic gastritis treated by mid-dose of the traditional Chinese drug prescription based on asthenia syndrome, depression syndrome, poison syndrome, static blood syndrome.Conclusions: The therapeutic effect of atrophic gastritis treated by the traditional Chinese drug prescription based on asthenia syndrome, depression syndrome, poison syndrome, static blood syndrome is reliable.%目的:观测从虚郁毒瘀立法组方对萎缩性胃炎鼠模型胃黏膜病理形态的干预作用.方法:采用乙醇+去氧胆酸钠+氨水+吲哚美辛+饥饱失常综合法复制萎缩性胃炎鼠模型,并用从虚郁毒瘀立法组方低、中、高剂量分别进行干预,从对胃黏膜炎症及萎缩分度、胃黏膜厚度方面的影响观测各剂量组的治疗效果.结果:从虚郁毒瘀立法组方中剂量组可明显改善萎缩性鼠模型胃黏膜的炎症和萎缩程度,以及胃黏膜的厚度.结论:从虚郁毒瘀立法组方治疗萎缩性胃炎疗效可靠.

  12. Estimation of efficiency eradication therapies at sick of inflammatory periodontal diseases against a chronic Helicobacter pylori gastritis

    Directory of Open Access Journals (Sweden)

    Bulkina N.V.

    2011-03-01

    Full Text Available As a result of the conducted research results of an estimation of efficiency of application of the general eradication are presented therapy and local therapy at sick of inflammatory periodontal diseases against a chronic gastritis. Authors notice a positive effect at application as pathogenetic therapy of balm for gums of "Asepta" that normalisation of level of hygiene of the oral cavity, proof remission of periodontal diseases against a pathology of a gastroenteric path allows to achieve

  13. Expression of cytokeratins in Helicobacter pylori-associated chronic gastritis of adult patients infected with cagA + strains: An immunohistochemical study

    Institute of Scientific and Technical Information of China (English)

    Vera Todorovic; Aleksandra Sokic-Milutinovic; Neda Drndarevic; Marjan Micev; Olivera Mlitrovic; Ivan Nikolic; Thomas Wex; Tomica Milosavljevic; Peter Malfertheiner

    2006-01-01

    AIM: To investigate the expression of different cytokeratins (CKs) in gastric epithelium of adult patients with chronic gastritis infected with Helicobacter pylori(H pylori) cagA + strains.METHODS: The expression of CK 7, 8, 18, 19 and 20 was studied immunohistochemically in antral gastric biopsies of 84 patients. All the CKs were immunostained in cagA +H pylori gastritis (57 cases), non-Hpylori gastritis (17 cases) and normal gastric mucosa (10 cases).RESULTS: In cagA+ Hpylori gastritis, CK8 was expressed comparably to the normal antral mucosa from surface epithelium to deep glands. Distribution of CK18 and CK 19 was unchanged, i.e. transmucosal,but intensity of the expression was different in foveolar region in comparison to normal gastric mucosa. Cytokeratin 18 immunoreactivity was significantly higher in the foveolar epithelium of H pylori-positive gastritis compared to both Hpylori-negative gastritis and controls.On the contrary, decrease in CK19 immunoreactivity occurred in foveolar epithelium of H pylori-positive gastritis. In both normal and inflamed antral mucosa without H pylori infection, CK20 was expressed strongly/ moderately and homogenously in surface epithelium and upper foveolar region, but in H pylori-induced gastritis significant decrease of expression in foveolar region was noted. Generally, in both normal antral mucosa and H pylori-negative gastritis, expression of CK7 was not observed, while in about half cagA+ H pylori-infected patients, moderate focal CK7 immunoreactivity of the neck and coiled gland areas was registered, especially in areas with more severe inflammatory infiltrate.CONCLUSION: Alterations in expression of CK 7, 18,19 and 20 together with normal expression of CK8 occur in antral mucosa of H pylori-associated chronic gastritis in adult patients infected with cagA+ strains. Alterations in different cytokeratins expression might contribute to weakening of epithelial tight junctions observed in H pylori-infected gastric mucosa.

  14. Therapeutic effects of oral rebamipide and in combination with cimetidine on experimental gastritis in rats.

    Science.gov (United States)

    Kishimoto, S; Fujimura, J; Machino, H; Shimamoto, T; Kobayashi, H; Shimizu, S; Haruma, K; Kajiyama, G; Sakurai, K; Yamasaki, K

    1992-12-01

    The present study evaluated the therapeutic effects of rebamipide alone and in combination with cimetidine on experimental gastritis established by the administration of 5 mM sodium taurocholate (TCA) for 6 months in rats. Morphological and biochemical analyses were performed to determine the effects of rebamipide, administered alone or in combination with cimetidine, on chronic, atrophic and erosive gastritis. Rebamipide and cimetidine were administered to rats as a dietary admixture for 4 weeks after withdrawal of TCA. Rebamipide dose-dependently reduced the total length of the erosion, normalized the mucosal thickness and increased the number of parietal and total cells, and tended to reduce interstitial infiltration of inflammatory cells and proliferation of collagenous fibers. Moreover, histochemical and biochemical studies also showed rebamipide to be effective. Rebamipide increased the PAS-positive mucus and normalized the reduced gastric mucosal SOD activity. The therapeutic effect of rebamipide on the experimental gastritis was enhanced by the combined use of cimetidine. These results suggest that rebamipide has a therapeutic effect on chronic atrophic erosive gastritis induced by TCA, and that the mechanism of the therapeutic effect is partially due to the increase in PAS-positive mucus and gastric mucosal SOD activity. Furthermore, the enhanced effect of the combination therapy of rebamipide with cimetidine was considered to be due to the actions of both cimetidine and rebamipide. PMID:1335596

  15. Scintigraphic test of gastric emptying and motility: preliminary results in patients with chronic gastritis

    Energy Technology Data Exchange (ETDEWEB)

    Hausmann, T. [Abt. Nuklearmedizin und Spezielle Biophysik, Medizinische Hochschule Hannover (Germany); Mueller-Schauenburg, W. [Abt. Nuklearmedizin, Univ. Tuebingen (Germany); Goeke, M. [Abt. Gastroenterologie und Hepatologie, Medizinische Hochschule Hannover (Germany); Luebeck, M. [Abt. Nuklearmedizin, Univ.-Krankenhaus Eppendorf, Hamburg (Germany); Gratz, K.F. [Abt. Nuklearmedizin und Spezielle Biophysik, Medizinische Hochschule Hannover (Germany); Meier, P. [Abt. Gastroenterologie und Hepatologie, Medizinische Hochschule Hannover (Germany); Manns, M. [Abt. Gastroenterologie und Hepatologie, Medizinische Hochschule Hannover (Germany); Hundeshagen, H. [Abt. Nuklearmedizin und Spezielle Biophysik, Medizinische Hochschule Hannover (Germany)

    1995-11-01

    To record gastric peristalsis using a conventional scintigraphic gastric emptying test the frame rate was increased to 1 frame per 3 s at 10, 30, and 50 min postprandially. The gastric contraction frequency was obtained from the first harmonic of a Fourier transform of a gastric region of interest (ROI) curve. The propagation of gastric contractions was better revealed from computed functional images of the phase and amplitude distribution as compared with the multiple scintigraphic images. The maximal count-rate changes per pixel were calculated as an estimate of the most prominent regional contractile activity of the gastric wall. Among 12 patients with chronic gastritis the group with more severe dyspeptic complaints (n = 6) had significantly higher count-rate changes per pixel when compared with the group with minor complaints (20.0, 21.1 and 14.2 vs 12.9, 12.0, and 10.4 counts/pixel X s at 10, 30, and 50 min. respectively; p < 0.05). The mean half-times of gastric emptying (61, SD 11 vs 54, SD 13 min) and the mean gastric contraction frequencies (2.99, SD 0.19; 3.09, SD 0.33; 3.07, SD 0.10 vs 3.15, SD 0.15; 3.17, SD 0.13; 3.23, SD 0.20 cycles/min at 10, 30, and 50 min, respectively) did not show significant differences between both groups. Our preliminary results agree with the hypothesis of the occurrence of more powerful, nonexpulsive gastric-wall contractions in patients with more severe dyspeptic complaints. Hence, additional quantification of gastric motility allowed a more detailed evaluation of gastric-motor-activity disorders that were for so long not accessible to conventional gastric-emptying tests. (orig.)

  16. A case of collagenous gastritis resembling nodular gastritis in endoscopic appearance.

    Science.gov (United States)

    Tanabe, Jun; Yasumaru, Masakazu; Tsujimoto, Masahiko; Iijima, Hideki; Hiyama, Satoshi; Nishio, Akira; Sasayama, Yoshiaki; Kawai, Naoki; Oshita, Masahide; Abe, Takashi; Kawano, Sunao

    2013-12-01

    A 25-year-old Japanese female was referred to our clinic for the investigation of moderate iron-deficiency anemia and epigastralgia. Endoscopic examination showed diffuse mucosal nodules in the gastric body resembling nodular gastritis, but this pattern was not observed in the antrum. Histology of the gastric biopsies taken from the gastric body showed mild atrophic mucosa with chronic active inflammation. Some of the biopsy specimens showed deposition of patchy, band-like subepithelial collagen. Four years later, the patient showed no clinical symptoms and signs. A follow-up endoscopic examination showed similar findings, which mimicked pseudopolyposis or a cobblestone-like appearance. The biopsy specimens from the depressed mucosa between the nodules revealed a thickened subepithelial collagen band with no improvement, which led to a diagnosis of collagenous gastritis. Treatment with oral administration of proton-pump inhibitors and histamine-2-receptor antagonists had proved ineffective. To make a correct diagnosis of collagenous gastritis, we should determine the characteristic endoscopic findings and take biopsies from the depressed mucosa between the nodules. PMID:26182135

  17. [Collagenous gastritis and ileo-colitis occurred in autoimmune context: report of a case and review of the literature].

    Science.gov (United States)

    Macaigne, Gilles; Boivin, Jean-François; Harnois, Florence; Chayette, Claude; Dikov, Dorian; Cheaib, Sadek; Auriault, Marie-Luce

    2010-09-01

    Collagenous colitis belongs to the group of microscopic colitis. The aetiology and pathogenesis are unknown but different pathogenic hypothesis, autoimmune, infectious, alimentary and medicinal being are advanced, the last one being the most frequent aetiology. The collagenous gastritis is a rare entity and its association with collagenous colitis was exceptionally reported, only six cases being published. We report the seventh case of collagenous gastritis, ileitis and colitis in a 75-year-old woman with chronic diarrhea and important weight loss. This thickened subepithelial collagen band was appeared in an autoimmune injury context with antecedent of Hashimoto's thyroiditis and probably chronic atrophic Biermer's gastritis. The clinical and histological evolution was favourable with budesonide. PMID:20637552

  18. Therapeutic effects of sofalcone on experimental gastritis.

    Science.gov (United States)

    Kishimoto, S; Okamoto, K; Kambara, A; Kajiyama, G; Miyoshi, A; Suwa, T

    1987-08-01

    A study was made on the therapeutic effects of sofalcone (SU-88), an antiulcer agent, on erosive and atrophic gastritis induced experimentally by 6-month administration of 5 mmol/l of sodium taurocholate (TCA) in rats. A standard meal including sofalcone of 0.25% and 1.0% shortened the total length of erosions, normalized the mucosal thickness, and reduced collagenous fibers in the gastric mucosa in one month. The doses administered were 116.3 mg and 486.1 mg/kg/week for one month. Sofalcone, thus, had a good therapeutic effect on experimental erosive and atrophic gastritis in rats. PMID:3675690

  19. Comparison of Helicobacter pylori infection and gastric mucosal histological features of gastric ulcer patients with chronic gastritis patients

    Institute of Scientific and Technical Information of China (English)

    Chuan Zhang; Nobutaka Yamada; Yun-Lin Wu; Min Wen; Takeshi Matsuhisa; Norio Matsukura

    2005-01-01

    AIM: To compare Helicobacter pyloriinfection and gastric mucosal histological features of gastric ulcer patients with chronic gastritis patients in different age groups and from different biopsy sites.METHODS: The biopsy specimens were taken from the antrum, corpus and upper angulus of gastric ulcer and chronic gastritis patients. Giemsa staining, improved Toluidine-blue staining and H pylori-specific antibody immune staining were performed as appropriate for the histological diagnosis of H pylori infection. Hematoxylineosin staining was used for the histological diagnosis of activity of H pylori infection, mucosal inflammation,glandular atrophy and intestinal metaplasia and scored into four grades according to the Updated Sydney System.RESULTS: Total rate of H pylori infection, mucosal inflammation, activity of H pylori infection, glandular atrophy and intestinal metaplasia in 3 839 gastric ulcer patients (78.5%, 97.4%, 82.1%, 61.1% and 64.2%,respectively) were significantly higher than those in 4 102chronic gastritis patients (55.0%, 90.3%, 56.2%, 36.8%,and 37.0%, respectively, P<0.05). The rate of H pylori colonization of chronic gastritis in <30 years, 31-40 years,41-50 years, 51-60 years, 61-70 years and >70 years age groups in antrum was 33.3%, 41.7%, 53.6%, 57.3%,50.7%, 43.5%, respectively; in corpus, it was 32.6%,41.9%, 53.8%, 60.2%, 58.0%, 54.8%, respectively; in angulus, it was 32.4%, 42.1%, 51.6%, 54.5%, 49.7%,43.5%, respectively. The rate of Hpyloricolonization of gastric ulcer in <30 years, 31-40 years, 41-50 years,51-60 years, 61-70 years and >70 years age groups in antrum was 60.5%, 79.9%, 80.9%, 66.8%, 59.6%, 45.6%,respectively; in corpus, it was 59.7%, 79.6%, 83.6%,80.1%, 70.6%, 59.1%, respectively; in angulus, it was61.3%, 77.8%, 75.3%, 68.8%, 59.7%, 45.8%,respectively. The rate of H pylori colonization at antrum was similar to corpus and angulus in patients, below50 years, with chronic gastritis and in patients, below40 years, with

  20. Effect of eradication of Helicobacter pylori on development and reversion of atrophic gastritis in animal study%幽门螺杆菌的根除与萎缩性胃炎形成和逆转的动物实验研究

    Institute of Scientific and Technical Information of China (English)

    胡品津; 曾志荣; 陈旻湖; 陈为; 彭晓忠; 林汉良

    2000-01-01

    were examined using anti-Brdu immunohistoche-mical staining and flow cytometry. Results (1) H. pylori turned to negative in all mice received eradication therapy. Significant improvement of chronic active gastritis was observed after eradication of H. pylori in both group A and B, no atrophic changes was seen at any time interval in group A, whereas in group B, atrophic changes were seen 12 months after H. pylori infection and no significant change of the degree of atrophy was observed 3 and 6 months after eradication of H. pylori. (2) The cell kinetic indexes (S%, PI and LI) in the experimental group before eradication of H. pylori were significantly higher than those in the control at any time interval (P 0.05 ). Conclusion The study suggests that eradication of H. pylori can improve gastric mucosal inflammation and epithelial cell kinetics of the sto-mach, and early treatment can prevent formation of mucosal atrophy. Once atrophy was established, eradica-tion of H. pylori has no effects on the return to normal but may prevent its progress.

  1. Study on the Classification of Chronic gastritis at molecular biological level

    Institute of Scientific and Technical Information of China (English)

    Goang-Yao Yin; Wu-Ning Zhang; Xue-Fen He; Yi Chen; Xiao-Jing Shen

    2003-01-01

    .05-0.001. There were synchronous changes of gastric mucosa epithelial cellular ultrastructure. The "background lesions" (focal atrophic gastritis, focal intestinal metaplasia, micro-ulcer) in nonfocal gastric mucosa of all groups had significant differences (P<0.05-0.001).CONCLUSION: Disease with symptoms, disease without symptoms, nondisease with symptoms occur on the basis of the quantitative changes of gastric mucosa epithelial cellular ultrastructure and related bioactive substances.

  2. Polymorphisms of DNA repair genes XRCC1 and XRCC3, interaction with environmental exposure and risk of chronic gastritis and gastric cancer

    Institute of Scientific and Technical Information of China (English)

    Márcia Cristina Duarte; Jucimara Colombo; Andrea Regina Baptista Rossit; Alaor Caetano; Aldenis Albaneze Borim; Durval Wornrath; Ana Elizabete Silva

    2005-01-01

    AIM: To evaluate the association between polymorphisms XRCC1 Arg194Trp and Arg399Gln and XRCC3Thr241Met and the risk for chronic gastritis and gastric cancer, in a Southeastern Brazilian population.METHODS: Genotyping by PCR-RFLP was carried out on 202 patients with chronic gastritis (CG) and 160 patients with gastric cancer (GC), matched to 202 (C1) and 150(C2) controls, respectively.RESULTS: No differences were observed among the studied grou ps with regard to the genotype distribution of XRCC1 codons 194 and 399 and of XRCC3 codon 241. However, the combined analyses of the three variant alleles (194Trp, 399Gln and 241Met) showed an increased risk for chronic gastritis when compared to the GC group. Moreover, an interaction between the polymorphic alleles and demographic and environmental factors was observed in the CG and GC groups. XRCC1 194Trp was associated with smoking in the CG group,while the variant alleles XRCC1 399Gln and XRCC3241Met were related with gender, smoking, drinking and H pylori infection in the CG and GC groups.CONCLUSION: Our results showed no evidence of a rela-tionship between the polymorphisms XRCC1Arg194Trp and Arg399Gln and XRCC3 Thr241Met and the risk of chronic gastritis and gastric cancer in the Brazilian population, but the combined effect of these variants may interact to increase the risk for chronic gastritis,considered a premalignant lesion. Our data also indicate a gene-environment interaction in the susceptibility to chronic gastritis and gastric cancer.

  3. Increased Cell Proliferation in Chronic Helicobacter pylori Positive Gastritis and Gastric Carcinoma – Correlation between Immuno-Histochemistry and Tv Image Cytometry

    Directory of Open Access Journals (Sweden)

    Erika Szaleczky

    2000-01-01

    Full Text Available Backgound: Epithelial cell proliferation activity has been reported both to be unaltered and increased in Helicobacter pylori (H. pylori associated chronic gastritis. The proliferation rate decreased following H. pylori eradication, but results are controversial whether this change is dependent on the success of eradication. We compared the cell proliferation activity of H. pylori positive and negative gastric epithelial biopsies in chronic gastritis with and without intestinal metaplasia (IM and gastric cancer by the expression of proliferation cell nuclear antigen (PCNA and Tv image cytometry, and assessed the effect of H. pylori eradication on the cell proliferation rate in the gastric epithelium.

  4. Reversing gastric mucosal alterations during ethanol-induced chronic gastritis in rats by oral administration of Opuntia ficus- indica mucilage

    Institute of Scientific and Technical Information of China (English)

    Ricardo Vázquez-Ramírez; Marisela Olguín-Martínez; Carlos Kubli-Garfias; Rolando Hernández-Mu(n)oz

    2006-01-01

    AIM: To study the effect of mucilage obtained from cladodes of Opuntia ficus-indica (Cactaceae) on the healing of ethanol-induced gastritis in rats.METHODS: Chronic gastric mucosa injury was treated with mucilage (5 mg/kg per day) after it was induced by ethanol. Lipid composition, activity of 5'-nucleotidase (a membrane-associated ectoenzyme) and cytosolic activities of lactate and alcohol dehydrogenases in the plasma membrane of gastric mucosa were determined.Histological studies of gastric samples from the experimental groups were included.RESULTS: Ethanol elicited the histological profile of gastritis characterized by loss of the surface epithelium and infiltration of polymorphonuclear leukocytes.Phosphatidylcholine (PC) decreased and cholesterol content increased in plasma membranes of the gastric mucosa. In addition, cytosolic activity increased while the activity of alcohol dehydrogenases decreased. The administration of mucilage promptly corrected these enzymatic changes. In fact, mucilage readily accelerated restoration of the ethanol-induced histological alterations and the disturbances in plasma membranes of gastric mucosa, showing a univocal anti-inflammatory effect.The activity of 5'-nucleotidase correlated with the changes in lipid composition and the fluidity of gastric mucosal plasma membranes.CONCLUSION: The beneficial action of mucilage seems correlated with stabilization of plasma membranes of damaged gastric mucosa. Molecular interactions between mucilage monosaccharides and membrane phospholipids,mainly PC and phosphatidylethanolamine (PE), may be the relevant features responsible for changing activities of membrane-attached proteins during the healing process after chronic gastric mucosal damage.

  5. Direct Needle Puncture and Embolization of Splenic Artery Pseudoaneurysm in Case of Chronic Atrophic Calcific Pancreatitis

    Science.gov (United States)

    Shrivastava, Amit; Rampal, Jagadeesh Singh; Reddy, D. Nageshwar; Rao, Guduru Venkat

    2016-01-01

    Summary Background Gastro-Intestinal bleeding remains a frequent clinical dilemma and common cause of hospitalization, morbidity and mortality. Case Report We report a case of pseudo aneurysm of splenic artery developed after an episode of acute on chronic pancreatitis which was treated by direct percutaneous puncture of pseudoaneurysm and embolization by coils. Conclusions The aim was to preserve the main splenic artery and avoid the complications of splenic artery embolization like infarcts and abscess. PMID:27757174

  6. Expressions of HSP 70 and NF-κB in the peripheral blood lymphocyte of chronic gastritis patients of different syndrome patterns

    Institute of Scientific and Technical Information of China (English)

    胡玲

    2012-01-01

    Objective To study the expressions of heat shock protein 70 (HSP 70) and nuclear factor-kappa B(NF-κB) in the peripheral blood lymphocyte of chronic gastritis (CG) patients of Pi-Wei hygropyrexia syndrome (PWHS) and Pi-qi deficiency syndrome(PQDS),and to explore their correlation with Helicobacter pylori(Hp) infection. Methods

  7. Gastric dilatation syndrome associated with chronic nephropathy, hypergastrinemia, and gastritis in mice exposed to high levels of environmental antigens.

    Science.gov (United States)

    García, A; Erdman, S; Sheppard, B J; Murphy, J C; Fox, J G

    2001-06-01

    Gastric dilatation (GD) has been observed in Tac:(SW)fBR surveillance mice, with mean age of 10 months, that are exposed to high levels of environmental antigens during routine exposure to dirty bedding. The aim of the study reported here was to determine whether GD was associated with other systemic conditions affecting mice. Three groups of nine animals including-surveillance mice not exposed to dirty bedding (control), surveillance mice with out GD (NGD), and surveillance mice with GD (group GD)-had mean stomach weight with ingesta of 0.5 +/- 0.02 g, 1.09 +/- 0.07 g (P < 0.0001), and 2.54 +/- 0.4 g (P < 0.0001), respectively. Mean serum creatinine concentration was significantly higher in GD (1.6 +/- 0.25 mg/dl), compared with NGD (0.17 +/- 0.22 mg/dl, P < 0.0001) and control (0.2 +/- 0.16 mg/ dl, P < 0.0001) mice. In addition, lesions consistent with severe chronic nephropathy and mild gastritis were common in GD, compared with NGD and control mice. Finally, serum amidated gastrin concentration was significantly high in GD (179.37 +/- 53.86 pM, P < 0.03) and NGD (264.89 +/- 115.89 pM, P < 0.009), compared with control (60.77 +/- 8.39 pM) mice. Gastric dilatation syndrome is associated with chronic nephropathy, hypergastrinemia, and gastritis in surveillance mice exposed to high levels of environmental antigens. PMID:11924783

  8. Clinical Effects of the Method for Warming the Middle-jiao and Strengthening the Spleen on Gastric Mucosa Repair in Chronic Gastritis Patients

    Institute of Scientific and Technical Information of China (English)

    Hu Lingjing; Hu Xiaomei; Yang Min; Xie Huimin; Xiang Yanghong

    2008-01-01

    Objective:To observe clinical effects of the method for warming the middle-jiao and strengthening the spleen on gastric mucosa repair in chronic gastritis patients.Methods:The 42 cases of the treatment group were orally adiministered Yiweikang Capsule(益胃康胶囊);while the other 25 cases in the control group wore orally given Wenweishu Capsule(温胃舒胶囊).Both the groups wore observed for 2 months.Results:The total effective rate in the treatment group was obviously higher than that of the control group(P<0.05),with statistical significance shown by the TCM symptom score,gastroscopic examination and the HP test (p<0.05 or P<0.01).Conclusions:Yiweikang Capsule(益胃康胶囊)iS an effeetive medicine for chronic gastritis.

  9. [Association of chronic urticaria with Helicobacter pylori-induced antrum gastritis].

    Science.gov (United States)

    Bohmeyer, J; Heller, A; Hartig, C; Wetenberger-Treumann, M; Huchzermeyer, H; Otte, H G; Stadler, R

    1996-02-01

    In spite of its high incidence, not much is known about the etiology of chronic urticaria. We performed gastroscopic evaluation of 10 patients in whom no cause for chronic urticaria had been found. In 8 of these 10 patients, Helicobacter pylori was identified in the gastric mucosa. The chronic urticarial lesions disappeared within a few days after starting therapy with amoxicillin and omeprazol. PMID:8868453

  10. Collagenous gastritis: Review.

    Science.gov (United States)

    Kamimura, Kenya; Kobayashi, Masaaki; Sato, Yuichi; Aoyagi, Yutaka; Terai, Shuji

    2015-03-16

    Collagenous gastritis is a rare disease characterized by the subepithelial deposition of collagen bands thicker than 10 μm and the infiltration of inflammatory mononuclear cells in the lamina propria. Collagenous colitis and collagenous sprue have similar histological characteristics to collagenous gastritis and are thought to be part of the same disease entity. However, while collagenous colitis has become more common in the field of gastroenterology, presenting with clinical symptoms of chronic diarrhea in older patients, collagenous gastritis is rare. Since the disease was first reported in 1989, only 60 cases have been documented in the English literature. No safe and effective treatments have been identified from randomized, controlled trials. Therefore, better understanding of the disease and the reporting of more cases will help to establish diagnostic criteria and to develop therapeutic strategies. Therefore, here we review the clinical characteristics, endoscopic and histological findings, treatment, and clinical outcomes from case reports and case series published to date, and provide a summary of the latest information on the disease. This information will contribute to improved knowledge of collagenous gastritis so physicians can recognize and correctly diagnose the disease, and will help to develop a standard therapeutic strategy for future clinical trials. PMID:25789098

  11. Preventive effects of geranylgeranylacetone on rat ethanol-induced gastritis

    OpenAIRE

    Ning, Jian-Wen; Lin, Guan-Bin; Ji, Feng; Xu, Jia; Sharify, Najeeb

    2012-01-01

    AIM: To establish a rat ethanol gastritis model, we evaluated the effects of ethanol on gastric mucosa and studied the preventive effects of geranylgeranylacetone on ethanol-induced chronic gastritis.

  12. Gene expression profiling in gastric mucosa from Helicobacter pylori-infected and uninfected patients undergoing chronic superficial gastritis.

    Directory of Open Access Journals (Sweden)

    Ze-Min Yang

    Full Text Available Helicobacter pylori infection reprograms host gene expression and influences various cellular processes, which have been investigated by cDNA microarray using in vitro culture cells and in vivo gastric biopsies from patients of the Chronic Abdominal Complaint. To further explore the effects of H. pylori infection on host gene expression, we have collected the gastric antral mucosa samples from 6 untreated patients with gastroscopic and pathologic confirmation of chronic superficial gastritis. Among them three patients were infected by H. pylori and the other three patients were not. These samples were analyzed by a microarray chip which contains 14,112 cloned cDNAs, and microarray data were analyzed via BRB ArrayTools software and Ingenuity Pathways Analysis (IPA website. The results showed 34 genes of 38 differentially expressed genes regulated by H. pylori infection had been annotated. The annotated genes were involved in protein metabolism, inflammatory and immunological reaction, signal transduction, gene transcription, trace element metabolism, and so on. The 82% of these genes (28/34 were categorized in three molecular interaction networks involved in gene expression, cancer progress, antigen presentation and inflammatory response. The expression data of the array hybridization was confirmed by quantitative real-time PCR assays. Taken together, these data indicated that H. pylori infection could alter cellular gene expression processes, escape host defense mechanism, increase inflammatory and immune responses, activate NF-κB and Wnt/β-catenin signaling pathway, disturb metal ion homeostasis, and induce carcinogenesis. All of these might help to explain H. pylori pathogenic mechanism and the gastroduodenal pathogenesis induced by H. pylori infection.

  13. Direct measurement of gastric H + / K +-ATPase activities in patients with or without Helicobacter pylori-associated chronic gastritis

    Institute of Scientific and Technical Information of China (English)

    Duangporn Thong-Ngam; Pisit Tangkijvanich; Pichet Sampatanukul; Paungpayom Prichakas; Varocha Mahachai; Piyaratana Tosukowong

    2005-01-01

    AIM: The role of Helicobacter pylori (H pylori) infection in gastric acid secretion of patients with chronic gastritisremains controversial. This study was designed to elucidate the effect of H pylori on H+/K+-ATPase activities in gastric biopsy specimens.METHODS: Eighty-two patients with chronic gastritis who had undergone upper endoscopy were included in this study. H pylori infection was confirmed by rapid urease test and histology. Gastric H+/K+-ATPase activities and serum gastrin concentrations were measured by an enzymatic method and radioimmunoassay, respectively. For those patients who received triple therapy for eradicating H pylori, changes in the activity of gastric H+/K+-ATPase and serum gastrin levels were also measured. RESULTS: The mean gastric H+/K+-ATPase activity in H pyloripositive group (42 patients) was slightly higher than thatin H pylori-negative group (29 patients) (169.65±52.9 and eradication of H pylori, the gastric H+/K+-ATPase activities slightly decreased compared to prior therapy (165.03±59.50 The mean basal gastrin concentration was slightly higher in H pylori-positive patients than in H pylori-negative patients (87.92±39.65 pg/mL vs75.04± 42.57 pg/mL, P= 0.228). The gastrin levels fell significantly after the eradication of Hpylori. (Before treatment 87.00±30.78 pg/mL, aftertreatment 64.73±18.96 pg/mL, P = 0.015).CONCLUSION: Gastric H+/K+-ATPase activities are not associated with H pylori status in patients with chronicgastritis.

  14. Progressive genomic convergence of two Helicobacter pylori strains during mixed infection of a patient with chronic gastritis

    Science.gov (United States)

    Cao, Qizhi; Didelot, Xavier; Wu, Zhongbiao; Li, Zongwei; He, Lihua; Li, Yunsheng; Ni, Ming; You, Yuanhai; Lin, Xi; Li, Zhen; Gong, Yanan; Zheng, Minqiao; Zhang, Minli; Liu, Jie; Wang, Weijun; Bo, Xiaochen; Falush, Daniel; Wang, Shengqi; Zhang, Jianzhong

    2015-01-01

    Objective To study the detailed nature of genomic microevolution during mixed infection with multiple Helicobacter pylori strains in an individual. Design We sampled 18 isolates from a single biopsy from a patient with chronic gastritis and nephritis. Whole-genome sequencing was applied to these isolates, and statistical genetic tools were used to investigate their evolutionary history. Results The genomes fall into two clades, reflecting colonisation of the stomach by two distinct strains, and these lineages have accumulated diversity during an estimated 2.8 and 4.2 years of evolution. We detected about 150 clear recombination events between the two clades. Recombination between the lineages is a continuous ongoing process and was detected on both clades, but the effect of recombination in one clade was nearly an order of magnitude higher than in the other. Imputed ancestral sequences also showed evidence of recombination between the two strains prior to their diversification, and we estimate that they have both been infecting the same host for at least 12 years. Recombination tracts between the lineages were, on average, 895 bp in length, and showed evidence for the interspersion of recipient sequences that has been observed in in vitro experiments. The complex evolutionary history of a phage-related protein provided evidence for frequent reinfection of both clades by a single phage lineage during the past 4 years. Conclusions Whole genome sequencing can be used to make detailed conclusions about the mechanisms of genetic change of H. pylori based on sampling bacteria from a single gastric biopsy. PMID:25007814

  15. Diagnosis of autoimmune gastritis by high resolution magnification endoscopy

    Institute of Scientific and Technical Information of China (English)

    George K Anagnostopoulos; Krish Ragunath; Anthony Shonde; Christopher J Hawkey; Kenshi Yao

    2006-01-01

    Endoscopic visualisation of gastric atrophy is usually not feasible with conventional endoscopy. Magnifying endoscopy is helpful to analyze the subepithelial microvascular architecture as well as the mucosal surface microstructure without tissue biopsy. Using this technique we were able to describe the normal gastric microvasculature pattern and we also identified characteristic patterns in two cases of autoimmune atrophic gastritis.

  16. Distribution of traditional Chinese medicine syndromes of chronic atrophic gastritis%慢性萎缩性胃炎中医证型分布规律

    Institute of Scientific and Technical Information of China (English)

    赵晓丹; 孙静晶; 周斌

    2015-01-01

    Objective To discuss the relationship among different TCM syndrome of CAG , relevant pathological changes and Helicobacter pylori infection .Methods 431 CAG patients were divided into 6 kinds of TCM syndromes , i.e.59 cases of liver and stomach qi stagnation syndrome , 35 cases of stagnated heat of liver and stomach syndrome , 168 cases of spleen-stomach deficiency syndrome , 52 cases of spleen-stomach damp heat syndrome , 24 cases of stomach yin deficiency syndrome and 93 cases of stomach merid-ian of blood stasis syndrome .To analysis the relationship among different syndrome , relevant pathological changes and Helicobacter pylori infection .Results (1)In the distribution of different degrees of atrophy , there were statistically significant differences among the six syndromes (P0.05).Conclusion There were correlation among TCM syndromes , pathological changes and Helicobacter pylori infection .%目的:探讨慢性萎缩性胃炎的中医证型分布与胃黏膜病理改变程度、幽门螺杆菌( H.pylori)感染的相关性。方法将431例慢性萎缩性胃炎患者辨证分为6个证型:肝胃气滞证59例,肝胃郁热证35例,脾胃虚弱证168例,脾胃湿热证52例,胃阴不足证24例,胃络瘀血证93例。分析各证型与胃黏膜病理改变程度、幽门螺杆菌感染的关系。结果(1)各中医证型在不同程度胃粘膜萎缩分布上存在显著性差异( P<0.05),其中肝胃气滞证与脾胃虚弱证、胃络瘀血证比较差异均有统计学意义(P<0.0033);(2)各中医证型在不同程度肠化生分布上存在显著性差异(P<0.05),其中,肝胃气滞证与胃络瘀血证比较存在显著性差异(P<0.0033);(3)各中医证型在不同程度异型增生分布上差异无显著性意义(P>0.05)。结论中医证型分布与胃黏膜病理改变程度、H.pylori感染有一定的相关性。

  17. Research on TCM Patterns Objectification of Chronic Superficial Gastritis%慢性浅表性胃炎中医证型客观化研究

    Institute of Scientific and Technical Information of China (English)

    占新辉; 王微; 符思; 王影; 张喆; 刘瑜

    2015-01-01

    从生化、免疫、基因等方面综述近年来慢性浅表性胃炎中医证型客观化指标的研究概况,以期为今后制定本病的中医辨证论治标准提供依据。%The general situation about objective indexes of TCM patterns of chronic superificial gastritis (CSG) in recent years were reviewed from biochemical, immune and genetic aspects in the hope of providing evidence for establishing the standard of syndrome differentiation and treatment for CSG.

  18. GSTT1,GSTM 1 and CYP2E1 genetic polymorphisms in gastric cancer and chronic gastritis in a Brazilian population

    Institute of Scientific and Technical Information of China (English)

    Jucimara Colombo; Andréa Regina Baptista Rossit; Alaor Caetano; Aldenis Albaneze Borim; Durval Wornrath; Ana Elizabete Silva

    2004-01-01

    AIM: To test the hypothesis that, in the Southeastern Brazilian population, the GSTT1, GSTM1 and CYP2E1polymorphisms and putative risk factors are associated with an increased risk for gastric cancer.METHODS: We conducted a study on 100 cases of gastric cancer (GC), 100 cases of chronic gastritis (CG), and 150controls (C). Deletion of the GSTT1 and GSTM1 genes was assessed by multiplex PCR. CYP2E1/PstI genotyping was performed using a PCR-RFLP assay.RESULTS: No relationship between GSTT1/GSTM1 deletion and the c1/c2 genotype of CYP2E1 was observed among the three groups. However, a significant difference between CG and C was observed, due to a greater number of GSTT1/GSTM1 positive genotypes in the CG group. The GSTT1 null genotype occurred more frequently in Negroid subjects, and the GSTM1 null genotype in Caucasians, while the GSTM1 positive genotype was observed mainly in individuals with chronic gastritis infected with H pylori.CONCLUSION: Our findings indicate that there is no obvious relationship between the GSTT1, GSTM1 and CYP2E1 polymorphisms and gastric cancer.

  19. Comparison of two cleansing pastes for the removal of biofilm from dentures and palatal lesions in patients with atrophic chronic candidiasis.

    Science.gov (United States)

    Andrucioli, Marcela Cristina Damião; de Macedo, Leandro Dorigan; Panzeri, Heitor; Lara, Elza Helena Guimarães; Paranhos, Helena de Freitas Oliveira

    2004-01-01

    The efficacy of 2 oral hygiene products, an experimental toothpaste specific for complete denture cleansing and a regular standard toothpaste, was compared in terms of denture biofilm removal and cure of palatal lesions in patients with atrophic chronic candidiasis. The degree of correlation between presence of biofilm and mucosa erythema was also evaluated. Twenty-four complete denture wearers (45-80 years old) were divided into 2 groups: experimental paste and standard toothpaste (Sorriso-Kolynos, Brazil). Both groups received soft toothbrushes. The internal surfaces of upper dentures were stained using 1% sodium fluorescein and photographed at a 45 masculine angle at 0, 15, 30 and 60 days. The slides were scanned and the areas of interest (denture total area and biofilm area) were measured (Image Tool software). The degree of erythema was evaluated on slides according to the Prosthesis Tissue Index. There was a significant reduction (1%) in the degree of biofilm (ANOVA/Tukey) between the two initial visits (0 and 15 days) and the two final visits (30 and 60 days), and in the average erythema scores (Kruskal-Wallis) between 0 and 60 days, in both groups. The Mann-Whitney test showed a significant difference (1%) between pastes in terms of biofilm degree, but no difference was found for the erythema score. Correlation values between biofilm and erythema degree were 0.3801 (experimental paste) and (0.3678 (standard toothpaste). We may therefore conclude that the experimental product was efficient for the removal of denture plaque biofilm.

  20. 焦虑抑郁障碍误诊为慢性胃炎的临床分析%Clinical Analysis of Anxiety-depression Disorder Misdiagnosed as Chronic Gastritis

    Institute of Scientific and Technical Information of China (English)

    朱祥路; 陈静

    2014-01-01

    This paper explores the relationship between anxiety-depression disorder and chronic gastritis .Out-patients and in patients with anxiety-depression disorder that were misdiagnosed as "chronic gastritis"were statistically analyzed in the mental department in the half a year .38 patients had gastroscopy ,37 of them showed "superficial gastritis" or "erosive gastritis",only 1 patients reported normal gastroscopy .40% (15 cases) of patients can be temporarily reduced by the treatment of "chronic gastritis",while 60% (23 cases) of patients were not only ineffective by the treatment of "chronic gastritis",but the symptoms aggravated .The results suggest that superficial gastritis and erosive gastritis are closely related with human emotions .Anxiety-depression disorder is one of the most common somatic symptoms .%探讨焦虑抑郁障碍与慢性胃炎之间的关系。统计半年内在心理科门诊及住院治疗的焦虑抑郁障碍患者中曾被误诊为“慢性胃炎”的情况。结果有38例患者做胃镜检查,其中37例患者显示“浅表性胃炎”或“糜烂性胃炎”,仅1例患者胃镜报告正常。40%(15例)按“慢性胃炎”治疗能暂时减轻症状,而60%(23例)按“慢性胃炎”治疗不仅无效,症状反而加重。研究结果提示浅表性胃炎或糜烂性胃炎与人的情绪紧密相关,是焦虑抑郁障碍最常见的躯体症状之一。

  1. Collagenous Gastritis: A Rare Entity

    Directory of Open Access Journals (Sweden)

    Faten Limaiem

    2015-06-01

    Full Text Available Collagenous gastritis is a rare entity of unknown etiology characterized histologically by the presence of a thick subepithelial collagen band associated with an inflammatory infiltrate of gastric mucosa. A 40-year-old male presented with a history of chronic intermittent abdominal pain for about 6 months. Physical examination was unremarkable, and biological tests were within normal range. The patient underwent esophagogastroduodenoscopy and colonoscopy which showed a nodular mucosa of the stomach. Biopsies of the duodenum and colon were unremarkable. However, biopsies of the gastric fundus revealed a mild chronic gastritis characterized by lymphocytic and plasma cell infiltration of deep mucosa, without lymphoid follicle formation or active inflammation. No microorganisms were identified on routine hematoxylin and eosin or Giemsa-stained sections. Subepithelial collagen in the gastric biopsies was thickened and showed entrapped capillaries. Subepithelial collagen was highlighted by Masson's trichrome staining and was negative for amyloid by Congo Red. In the areas containing thickened collagen, there were no intraepithelial lymphocytes. The final pathological diagnosis was collagenous gastritis. Collagenous gastritis is an extremely rare disease, but it is important to recognize its characteristic endoscopic and pathologic findings to make a correct diagnosis. Specific therapy for this rare entity has not yet been established. [J Interdiscipl Histopathol 2015; 3(2.000: 68-70

  2. The Basic Theory of Stress and Refractory Chronic Gastritis%应激的基本理论与难治性慢性胃炎

    Institute of Scientific and Technical Information of China (English)

    陈玉龙

    2012-01-01

    Endogenous, exogenous stress factors can affect on human psychological and neuroendocrine system, and the different character under same stress factors may have different stress response. Excessive stress is an important reason leading to psychosomatic illness. Most refractory chronic gastritis has close relationship with iatrogenic stress. The therapy of chronic gastritis and FD should be used as a treatment to relieve symptoms. It is not necessary to have too much emphasis on anti- Hp, the doctor should pay attention to regulate behavior, give a reasonable interpretation of the disease and avoid iatrogenic trauma of stress for patients in the clinical work, and reduce the incidence of iatrogenic mental illness.%内源性,外源性应激因素都会对人体心理和神经内分泌系统造成影响,在同一应激因素下由于人格不同可能有不同的应激反应.过度的应激是导致心身疾病的重要原因.多数难治性慢性胃炎和医源性应激关系密切,对慢性胃炎和FD在处理上应作为一种病去对症处理,不必过度强调抗Hp.医生在临床工作中,要注意规范言行,合理解释病情,避免医源性应激给患者带来心理创伤,减少医源性心理疾病的发生.

  3. Further study of mucosal repair by sofalcone in experimental gastritis.

    Science.gov (United States)

    Kishimoto, S; Kobuke, K; Kobayashi, H; Kajiyama, G; Miyoshi, A; Kohno, Y; Tanikawa, K; Ohta, K; Suwa, T

    1990-01-01

    The effect of sofalcone on the glandular structure and cell proliferation in the gastric mucosa of rats with gastritis induced by the administration of sodium taurocholate (TCA) for 6 months was examined by histoquantitative analysis and [3H]thymidine autoradiography. Morphometric observation revealed that, with TCA treatment, mucosal thickness, parietal cell mass, and the ratios of the length of the glandular portion/total length of the gastric gland were decreased in both the fundic and pyloric glands. Inflammatory cell infiltration and collagenous fiber proliferation were present in the gastric mucosa following TCA and indicated the presence of atrophic gastritis. These atrophic changes and inflammatory cell infiltration were reversed by a 3 week administration of sofalcone. Cellular proliferative activity assessed by the labeling indices of the gastric mucosa increased in TCA-induced gastritis in rats. The administration of sofalcone to rats with TCA-induced gastritis significantly increased labeling indices, particularly in the pyloric glands. From these results, it appears that sofalcone stimulates the compensatory increase in proliferative activity of generative cells, which then may become available to heal the gastritis. PMID:2212544

  4. Prof. Shan Zhaowei's Experience in Treating Atrophic Gastritis

    Institute of Scientific and Technical Information of China (English)

    Guo Lin; Wang Xinzhong

    2005-01-01

    @@ Prof. Shan Zhaowei ( 单兆伟 ), the author's teacher,has been engaged in TCM for more than 30 years,with profound knowledge in the treatment of diseases of the spleen and stomach, which are introduced in the following.

  5. LU Zheng's Experience in the Treatment of Atrophic Gastritis

    Institute of Scientific and Technical Information of China (English)

    CHEN Ming-xian

    2010-01-01

    @@ LU Zheng, male, born in 1938, a chief physician in Zhejiang Provincial Academy of TCM, is one of the second national batch of supervisors in the inheritance work of academic experiences of veteran TCM experts. He has his unique ideas on the TCM theories of toxicology, spleen and stomach, stimulation of kidney-qi, essential-qi, and kidneyessence. In clinical practice, he excels in treating diseases of internal medicine, gynecological and pediatric diseases, and the various stubborn and miscellaneous diseases.

  6. Collagenous Gastritis: A Rare Entity

    OpenAIRE

    Faten Limaiem; Sabeh Mzabi

    2015-01-01

    Collagenous gastritis is a rare entity of unknown etiology characterized histologically by the presence of a thick subepithelial collagen band associated with an inflammatory infiltrate of gastric mucosa. A 40-year-old male presented with a history of chronic intermittent abdominal pain for about 6 months. Physical examination was unremarkable, and biological tests were within normal range. The patient underwent esophagogastroduodenoscopy and colonoscopy which showed a nodular mucosa of the s...

  7. Kyoto global consensus report on Helicobacter pylori gastritis

    OpenAIRE

    Sugano, Kentaro; Tack, Jan; Kuipers, Ernst J.; David Y Graham; El-Omar, Emad M.; Miura, Soichiro; Haruma, Ken; Asaka, Masahiro; Uemura, Naomi; Malfertheiner, Peter

    2015-01-01

    Objective To present results of the Kyoto Global Consensus Meeting, which was convened to develop global consensus on (1) classification of chronic gastritis and duodenitis, (2) clinical distinction of dyspepsia caused by Helicobacter pylori from functional dyspepsia, (3) appropriate diagnostic assessment of gastritis and (4) when, whom and how to treat H. pylori gastritis. Design Twenty-three clinical questions addressing the above-mentioned four domains were drafted for which expert panels ...

  8. 金海生治疗慢性胃炎的经验%Professor Jin Haisheng experience in the Treatment of Chronic Gastritis

    Institute of Scientific and Technical Information of China (English)

    史瑞锋

    2011-01-01

    慢性胃炎指由外感内伤等诸多不同的原因引起的胃黏膜的慢性炎症或萎缩的病变.中医对本病的认识主要见于“胃脘痛”、“胃胀”、“纳呆”、“呕吐”、“痞满”、“反酸”、“嘈杂”等.金海生老中医对本病的诊治特点是:抓住“四纲”、“一中心”、“两疏通”,通过精细辨证,合理疏方,因此屡获良效.%Chronic gastritis is caused by a variety of causes. It refers to chronic gastric inflammation or atrophy of the lesion. Traditional knowledge of the disease is mainly reflected in the "stomach pain," "bloating," "indigestion," "vomiting" ."full ness" ,"acid regurigitation" ," noisy" and so on. Jin Haisheng,a veteran practioner of TCM,diagnosis and treatment of this dis ease is characterized by; the "four Programme" ,"a center" /'clear the two roads". Because of careful identification and prepara tion of a reasonable prescription, the treatment can get good effect.

  9. 金海生治疗慢性胃炎的经验%Professor Jin Haisheng experience in the Treatment of Chronic Gastritis

    Institute of Scientific and Technical Information of China (English)

    史瑞锋

    2011-01-01

    慢性胃炎指由外感内伤等诸多不同的原因引起的胃黏膜的慢性炎症或萎缩的病变.中医对本病的认识主要见于“胃脘痛”、“胃胀”、“纳呆”、“呕吐”、“痞满”、“反酸”、“嘈杂”等.金海生老中医对本病的诊治特点是:抓住“四纲”、“一中心”、“两疏通”,通过精细辨证,合理疏方,因此屡获良效.%Chronic gastritis is caused by a variety of causes. It refers to chronic gastric inflammation or atrophy of the lesion. Traditional knowledge of the disease is mainly reflected in the " stomach pain," " bloating," " indigestion," " vomiting" ," full ness" ," acid regurigitation" ," noisy" and so on. Jin Haisheng, a veteran practioner of TCM, diagnosis and treatment of this dis ease is characterized by: the "four Programme" ,"a center" /'clear the two roads". Because of careful identification and prepara tion of a reasonable prescription, the treatment can get good effect.

  10. [NONINVASIVE DIAGNOSTICS OF THE PHENOTYPE OF GASTRITIS: ANALISIS OF THE FIRST THOUSAND OF CASES].

    Science.gov (United States)

    Belkovets, A V; Kurilovich, S A; Reshetnikov, O; Ragino, Yu I; Scherbakova, L V

    2015-01-01

    The analysis of noninvasive diagnostics of a phenotype of gastritis among 1050 people aged from 18 till 80 years which consistently addressed to policlinic is presented in the article. The instrument of diagnostics was a , including a complex of biomarkers - so-called (pepsinogen I, pepsinogen II, gastrin-17 and IgG- antibodies to Helicobacter Pylori). High frequency of different variants of atrophic gastritis (25%) with a gastric cancer risk and conditions with a risk of erosive and ulcer damages of the stomach mucous (26 %) was shown. Clinical and economical expediency of noninvasive screening of a phenotype of gastritis is postulated.

  11. 影响慢性胃炎发展为胃癌的相关因素分析%Analysis of related factors in the development of chronic gastritis to gastric cancer

    Institute of Scientific and Technical Information of China (English)

    王建国

    2015-01-01

    Objective To study the related factors in the development of chronic gastritis to gastric cancer, and to explore effective preventive measures. Methods Ninety-two patients with chronic gastritis and gastric cancer in our hospital from November 2011 to November 2014 were selected as observation group. And 92 patients who were diag-nosed with only chronic gastritis by gastroscope and pathological examination during the same period were selected as control group. The influence factors in the development of chronic gastritis to gastric cancer were analyzed by single factor analysis and logistic regression analysis. Results The related factors included pickles, hot food, mildew foods, fried foods, smoking, drinking, breakfast, diet, daily salt intake, intermittent use of acid and antacid drugs, history of digestive disease (P<0.05). Taking the above factors into logistic multivariate regression analysis, the result showed that pickles, mildew food, fried food, irregular diet, a history of digestive disease were risk factors in the development of chronic gastritis to gastric cancer, and that continuous use of acid and antacid drugs were protection factors (P<0.05). Conclusion The development of chronic gastritis to gastritis cancer is mainly related to eating habits, history of diges-tive disease. Good diet can reduce the risk of cancer in patients with chronic gastritis.%目的:研究慢性胃炎发展为胃癌的影响因素,探讨有效的预防措施。方法选择2011年11月至2014年11月在我院接受治疗的慢性胃炎合并胃癌患者92例作为观察组。选取同期经胃镜和病理学检查确诊为慢性胃炎的患者92例作为对照组。用单因素分析和Logistic回归分析慢性胃炎发展为胃癌的影响因素。结果慢性胃炎发展为胃癌与腌菜、烫食、霉变食品、油炸食品饮酒、吸烟、早餐、饮食规律、每日摄盐量、间断使用抑酸和制酸药物、消化道病史等因素有关(P<0.05)。将上

  12. Serum TNF-α, IL-8, VEGF Levels in Helicobacter pylori Infection and Their Association with Degree of Gastritis

    Directory of Open Access Journals (Sweden)

    Gontar A Siregar

    2015-04-01

    Full Text Available Aim: to investigate the serum levels of TNF-α, IL-8, VEGF in Helicobacter pylori infection, and their association with the degrees of gastritis histopathology. Methods: a cross-sectional study was done on 80 consecutive gastritis patients admitted to endoscopy units at Adam Malik General Hospital and Permata Bunda Hospital, Medan, Indonesia from July-December 2014. The Rapid Urease test was used for the diagnosis of H. pylori infection. The severity of chronic inflammation, neutrophil infiltration, atrophy, and intestinal metaplasia were assessed. Serum samples were obtained to determine circulating TNF-α, IL-8, and VEGF. Univariate and bivariate analysis (chi square, fisher’s exact, and mann-whitney test were done using SPSS version-22. Results: there were 41.25% of 80 patients infected with Helicobacter pylori. Serum TNF-α and VEGF levels in the infected group were significantly higher compared to H. pylori negative, but there were no significant differences between serum levels of IL-8 in H. pylori positive and negative. There were significant associations between serum level of TNF-α and IL-8 with degree of chronic inflammation, and also between serum level of IL-8 and degree of neutrophil infiltration. There were significant associations between serum level of VEGF and degree of atrophy, and also between serum level of VEGF and degree of intestinal metaplasia. Conclusion: High levels of TNF-α were associated with severe degree of chronic inflammation, high levels of IL-8 associated with severe degree of chronic inflammation and neutrophil infiltration, and high levels of VEGF associated with severe degree of premalignant gastric lesion. Key words: cytokine, neoangiogenesis, Helicobacter pylori, atrophic gastritis, intestinal metaplasia.

  13. Collagenous gastritis in a young Japanese woman.

    Science.gov (United States)

    Kajino, Yuri; Kushima, Ryoji; Koyama, Shigeki; Fujiyama, Yoshihide; Okabe, Hidetoshi

    2003-03-01

    Collagenous gastritis, a counterpart of collagenous colitis, is a rare disorder with less than 20 cases reported in the literature. A case of collagenous gastritis in a Japanese woman in her early 20s who had been receiving treatment for atopic dermatitis and bronchial asthma is reported. The patient complained of repeated epigastric pain, and endoscopy revealed multifocal atrophic areas and scars in the gastric body. Biopsy specimens showed a thickened eosinophilic band-like structure with entrapped capillaries approximately 30-70 micro m thick beneath the surface epithelium. It was regarded as a collagen band because it was positive on Azan staining but negative on amyloid staining. This finding was accompanied by marked infiltration of mononuclear cells and eosinophils in the lamina propria; however, no evidence of lymphocytic gastritis was found. Helicobacter pylori infection was not detected and inflammatory cell infiltration was minimal in the mucosa without the collagen band. Immunohistochemical analysis revealed that the band was positive for type III and type VI collagen. The size of the collagen band did not change for 2 years. These findings suggest that subepithelial collagen deposition was due to an abnormal local immune response based on generalized allergic disorder. PMID:12608899

  14. Mast cell gastritis: Children complaining of chronic abdominal pain with histologically normal gastric mucosal biopsies except for increase in mast cells, proposing a new entity

    Science.gov (United States)

    Mahjoub, Fatemeh E; Farahmand, Fatemeh; Pourpak, Zahra; Asefi, Hoda; Amini, Zahra

    2009-01-01

    Background Mast cells reside within the connective tissue of a variety of tissues and all vascularized organs. Since 1996, few studies have been performed on mast cell density in gastrointestinal biopsies, mainly in adult age group. We recently studied mast cell density in pediatric age group on rather larger number of cases in a referral children hospital. Mast cell density was 12.6 ± 0.87 in 0.25 mm2 (range: 0-81) in our study. Since we frequently encounter cases with rather normal gastric biopsies with no H.pylori, which mainly complain of chronic abdominal pain, we gathered those cases with mast cell density more than 30/0.25 mm2. from 895 gastric biopsies and wanted to study their clinical and endoscopic findings and propose a new entity. Methods Between April 2005 and May 2008, 895 children (< 14 years old), with gastrointestinal complaints who underwent endoscopy were selected and antral biopsies were obtained for histological examination. Among these children, those who had normal or erythematous (but not nodular or ulcerative) gastric mucosa on endoscopic view, plus pathologic report of normal mucosa or mild gastritis in addition to mast cell count more than 30/25 mm2, were chosen and a questionnaire was filled for each patient including clinical, endoscopic and pathologic findings. The statistical analysis was performed using SPSS, version 13 (SPSS Inc., Chicago, IL, USA). Results Over a 3 year period of study, of 895 selected children, 86 patients fulfilled the entrance criteria. The major complaint of patients was recurrent abdominal pain. The mean mast cell density was 45.59 ± 13.81 in 0.25 mm2 (range: 30-93). Among our cases, about 67.4% (n = 58) had 30 to 49, 23.3% (n = 20) had 50 to 69, 8.1% (n = 7) had 70 to 89 and 1.2% (n = 1) had 93 mast cells/0.25 mm2 in their specimens Discussion In 29% of our cases, neither endoscopic nor pathologic change was detected and only increase in mast cell number was reported and in others endoscopic and

  15. A clinical study on the relationship between oral hygiene and chronic gastritis.%口腔卫生与慢性胃炎关系的临床研究

    Institute of Scientific and Technical Information of China (English)

    陈发明; 孙海花; 刘民; 张修平; 邓玲玲

    2001-01-01

    目的:为探讨口腔卫生与慢性胃炎的关系。方法:76例胃粘膜幽门螺杆菌(Helicobacterpylori,Hp)检测阳性慢性胃炎患者为慢性胃炎组,72例健康自愿者组成对照组,对所有受检者进行口腔卫生检查,并对其牙菌斑Hp进行检测,比较两组的差别;慢性胃炎组随机分成A、B两组后接受抗Hp治疗,A组同时进行口腔治疗与口腔教育,B组为对照,3月后观察抗Hp治疗的疗效,比较两组的差别。结果:慢性胃炎组口腔卫生状况明显较对照组差(P<0.01),且口腔卫生状况与慢性胃炎程度有关(P<0.05);牙菌斑Hp检测结果亦显示口腔卫生愈差、慢性胃炎愈严重,Hp阳性率愈高。3月后A组的疗效明显优于B组。结论:口腔卫生好坏与慢性胃炎的发病密切相关,Hp寄生于牙菌斑可能是导致慢性胃炎发病和复发的一个重要因素。%Objective:To investigate the relationship between oral hygieneand chronic gastritis.Methods:76 patients with chronic gastritis (Helicobacter pylori polymerase chain reaction detection were positive, Hp-PCR positive) and 72 controls were studied their oral hygiene and the Hp in their dental plaque.Chronic gastritis patients were received anti-Hp therapy and then divided into 2(A and B)groups.A group was treated by supergingival subgingival curettage,and received oral health education while B group was compared.Results:There were significant differences of Hp positive rate and debris index(DI),calculus index(CI),plaque index(PLI),gingival index(GI) between chronic gastritis group and control group(P<0.01),and they all related with the severity of chronic gastritis(P<0.01).Oral hygiene treatment and oral health education are benefit for anti-Hp therapy of chronic gastritis.Concusions:It is indicated that the relationship between oral hygiene and chronic gastritis is close clinically,Hp in dental plaque perhaps is one of the way to Hp infecton.

  16. Collagenous gastritis: a report of six cases.

    Science.gov (United States)

    Lagorce-Pages, C; Fabiani, B; Bouvier, R; Scoazec, J Y; Durand, L; Flejou, J F

    2001-09-01

    Collagenous gastritis is an exceptional entity with eight cases documented to date characterized by the presence of a thick subepithelial collagen band associated with an inflammatory infiltrate of the gastric mucosa. The aim of our study was to describe the clinical and histologic characteristics of six new cases of collagenous gastritis. All cases showed a subepithelial collagen band that averaged 30 microm but often measured up to 120 microm. This finding was almost always accompanied by mixed chronic inflammation in the lamina propria and by surface epithelial damage of varying severity. Our study seems to delineate two subsets in patients with collagenous gastritis: 1) collagenous gastritis occurring in children and young adults presenting with severe anemia, a nodular pattern on endoscopy, and a disease limited to the gastric mucosa without evidence of colonic involvement, and 2) collagenous gastritis associated with collagenous colitis occurring in adult patients presenting with chronic watery diarrhea. These findings highlight the fact that subepithelial collagen deposition may be a generalized disease affecting the entire gastrointestinal tract. PMID:11688577

  17. Collagenous gastritis: Review

    OpenAIRE

    Kamimura, Kenya; Kobayashi, Masaaki; Sato, Yuichi; Aoyagi, Yutaka; Terai, Shuji

    2015-01-01

    Collagenous gastritis is a rare disease characterized by the subepithelial deposition of collagen bands thicker than 10 μm and the infiltration of inflammatory mononuclear cells in the lamina propria. Collagenous colitis and collagenous sprue have similar histological characteristics to collagenous gastritis and are thought to be part of the same disease entity. However, while collagenous colitis has become more common in the field of gastroenterology, presenting with clinical symptoms of chr...

  18. Mast cell gastritis: Children complaining of chronic abdominal pain with histologically normal gastric mucosal biopsies except for increase in mast cells, proposing a new entity

    Directory of Open Access Journals (Sweden)

    Pourpak Zahra

    2009-10-01

    Full Text Available Abstract Background Mast cells reside within the connective tissue of a variety of tissues and all vascularized organs. Since 1996, few studies have been performed on mast cell density in gastrointestinal biopsies, mainly in adult age group. We recently studied mast cell density in pediatric age group on rather larger number of cases in a referral children hospital. Mast cell density was 12.6 ± 0.87 in 0.25 mm2 (range: 0-81 in our study. Since we frequently encounter cases with rather normal gastric biopsies with no H.pylori, which mainly complain of chronic abdominal pain, we gathered those cases with mast cell density more than 30/0.25 mm2. from 895 gastric biopsies and wanted to study their clinical and endoscopic findings and propose a new entity. Methods Between April 2005 and May 2008, 895 children (2, were chosen and a questionnaire was filled for each patient including clinical, endoscopic and pathologic findings. The statistical analysis was performed using SPSS, version 13 (SPSS Inc., Chicago, IL, USA. Results Over a 3 year period of study, of 895 selected children, 86 patients fulfilled the entrance criteria. The major complaint of patients was recurrent abdominal pain. The mean mast cell density was 45.59 ± 13.81 in 0.25 mm2 (range: 30-93. Among our cases, about 67.4% (n = 58 had 30 to 49, 23.3% (n = 20 had 50 to 69, 8.1% (n = 7 had 70 to 89 and 1.2% (n = 1 had 93 mast cells/0.25 mm2 in their specimens Discussion In 29% of our cases, neither endoscopic nor pathologic change was detected and only increase in mast cell number was reported and in others endoscopic and histopathological findings were negligible except increase in mast cells. In updated Sydney system (classification and grading of gastritis, no term is introduced which is in concordance with this group but we think that increased density of mast cells in these cases should not be overlooked and it may contribute to clinical manifestations in some way. We hope that

  19. 健脾化浊降逆方治疗糖尿病合并慢性胃炎60例%Jianpi Huazhuo Jiangni Decoction"in the treatment of diabetes and 60 cases of chronic gastritis

    Institute of Scientific and Technical Information of China (English)

    姬小云; 陈立新; 吴湘萍; 薛国敏

    2015-01-01

    Objective: To observe the therapeutic effect of Jianpi HuazhuoJiangni Decoction "in the treatment of diabetes mellitus with chronicgastritis. Methods:select 120 cases of diabetic patients with chronic gastritis, were randomly divided into two groups, control group was givencommon treatment;the treatment group based on the general treatmentgiven Jianpi Huazhuo Jiangni Decoction orally, 4 weeks of treatment,observe the clinical symptom of TCM improve blood sugar and meal andafter fasting 2 hours blood glucose change. Conclusion: Jianpi HuazhuoJiangni Decoction "in the treatment of diabetes mellitus with chronic gastritis curative effect is distinct.%目的:观察健脾化浊降逆方治疗糖尿病合并慢性胃炎的疗效。方法:选取120例确诊为糖尿病合并慢性胃炎患者,随机分为两组,对照组给予一般治疗;治疗组在一般治疗的基础上给予口服健脾化浊降逆方中药口服,治疗4周,观察中医临床症候改善情况及空腹血糖及餐后2h血糖变化。结论:健脾化浊降逆方治疗糖尿病合并慢性胃炎疗效显著。

  20. Endoscopic gastritis, serum pepsinogen assay, and Helicobacter pylori infection

    OpenAIRE

    Lee, Sun-Young

    2016-01-01

    Endoscopic findings of the background gastric mucosa are important in the Helicobacter pylori-seroprevalent population. It is strongly correlated not only with the risk of gastric cancer, but also with the excretion ability of gastric mucosa cells. In noninfected subjects, common endoscopic findings are regular arrangement of collecting venules, chronic superficial gastritis, and erosive gastritis. In cases of active H. pylori infection, nodularity on the antrum, hemorrhagic spots on the fund...

  1. Collagenous gastritis: a case report and review.

    Science.gov (United States)

    Ravikumara, Madhur; Ramani, Pramila; Spray, Christine H

    2007-08-01

    In this article, we report a case of collagenous gastritis in a child and review the paediatric cases reported to date. Collagenous gastritis is a rare entity, with only less than 30 cases reported so far, including 12 children, since the first description of this entity by Colletti and Trainer in 1989. This is a histological diagnosis characterised by a dramatically thickened subepithelial collagen band in the gastric mucosa associated with an inflammatory infiltrate. Children with this condition often present with epigastric pain and severe anaemia, with no evidence of extragastric involvement, in contrast to the adult patients, where chronic watery diarrhoea is the main presentation due to associated collagenous colitis. A macroscopic pattern of gastritis with nodularity of gastric mucosa, erythema and erosions are characteristic endoscopic findings in paediatric patients. Specific therapy has not been established and resolution of the abnormalities, either endoscopic or histological, has not been documented. In conclusion, collagenous gastritis is a rare entity of unknown aetiology, pathogenesis and prognosis. Gastroenterologists and pathologists need to be aware of this condition when evaluating a child with epigastric pain, anaemia and upper gastrointestinal bleeding, particularly when endoscopy reveals the nodularity of gastric mucosa. The identification, reporting and long-term follow-up of cases will shed more light on this puzzling condition. PMID:17453238

  2. 以反复腹痛为主要表现的慢性胃炎的临床特点和治疗%Clinical Features and Therapeutic Methods on Chronic Gastritis in Children with Abdominal Pain as Present Symptoms

    Institute of Scientific and Technical Information of China (English)

    张艳辉; 朱朝敏; 赵瑞秋; 姜雪莹

    2011-01-01

    Objective To analyze the clinical features and therapeutic methods on chronic gastritis in children with abdominal pain as present symptoms. Methods A total of 186 cases of chronic gastritis with abdominal pain( AP) as present symptoms, were involved in this study, and their clinical features and gastroscopy result were analyzed by gastroscopy. A stochastical follow - up was set to 84 cases, on their therapies and prognosis. Results Among the 186 cases,the course of AP in 36 cases less than 2 weeks,51 cases ranged 2 weeks to 3 months, 99 cases ranged 3 months to 10 years,in detail;AP in middle or upper abdomen in 85(45.7% ) cases,52 cases(28.0% ) in around navel and 23 cases(12.4% ) obscure. Fifty-five cases were complicated with nausea or vomiting (29.6% ) ,46 cases(24.7% ) with anore-xia,33 ca-ses(16.7%) with eructation ,21 cases(11.3%) with halitosis and 12 cases (6. 5%) with sour regurgitation. Seventeen cases infected by Hp were found. Between the patients with AP infected with or without Hp,there was no significant difference of the clinical manifestations (P,> 0.05 ) , while there was significant difference of gastroscopic findings (P 0.05). Conclusions AP in children with chronic gastritis has long -lasting and irregular,and AP localizes mainly in upper abdomen,which can be complicated with eructation,nausea or vomiting,anorexia,halitosis,etc. Antral nodularity is relatively distinctive in Hp - associated chronic gastritis while hyperemia and oedema of mucosa are common in non - Hp - associated chronic gastritis. The eradication therapy is necessary for the Hp - associated chronic gastritis. Instead of antibiotic therapy, general therapies including mucosa] protective agent, dietary therapy and alvi - dejections etc. Are necessary in non - Hp - associated chronic gastritis in children.%目的 探讨以反复腹痛为主要表现的小儿慢性胃炎的临床特点和治疗方法.方法 对本院以反复腹痛为主要表现的186例慢性胃炎患儿的

  3. 加味半夏泻心汤治疗慢性胃窦炎临床观察%Clinical Observation of Jiawei Banxiaxiexin Decoction in the Treatment of Chronic Antral Gastritis

    Institute of Scientific and Technical Information of China (English)

    李绍武

    2014-01-01

    目的:观察加味半夏泻心汤治疗慢性胃窦炎的临床疗效。方法:将120例寒热错杂型慢性胃窦炎患者随机分为治疗组和对照组,分别给予加味半夏泻心汤、斯达舒胶囊,均以30 d为一疗程。观察治疗后两组患者总有效率及治疗前后各组患者中医症候学评分,判断临床疗效。结果:治疗后,两组总有效率分别为81.67%和65.00%,治疗组优于对照组(P<0.01)。在中医症候学评分方面,治疗组优于对照组(P<0.05)。结论:加味半夏泻心汤对寒热错杂型慢性胃窦炎有较好的疗效。%Objective:To observe the clinical effect of Jiawei Banxiaxiexin decoction in treatment of chronic antral gastritis.Method:120 cases of chronic coldheat complex antral gastritis were randomized into treatment group and control group,treated respectively with Jiawei Banxiaxiexin decoction,Vitamin U, belladonna and aluminium capsules.To observed total efficiency of patients with evaluate the clinical effect,and Traditional Chinese Medicion(TCM) syndrome score after 30 days follow-up in the two groups.Result:After treatment,the total effective rate of treatment group(81.67%) was obviously better than that of control group(65.00%)(P<0.01).TCM symptom score between treatment group and control group showed significant differences (P<0.05).Conclusion:The therapeutic efect of Jiawei Banxiaxiexin decoction on chronic coldheat complex antral gastritis is satisfactory.

  4. Collagenous gastritis: a case report, morphologic evaluation, and review.

    Science.gov (United States)

    Vesoulis, Z; Lozanski, G; Ravichandran, P; Esber, E

    2000-05-01

    Collagenous gastritis is rare; there are only four previous case reports. Histologic features seem to overlap with the other "collagenous enterocolitides"; however, pathologic criteria are not yet established for the diagnosis of collagenous gastritis. We describe an additional case of ostensible collagenous gastritis in a patient who initially presented with celiac sprue and subsequently developed colonic manifestations of mucosal ulcerative colitis. Endoscopic biopsies of the stomach revealed deposition of patchy, very thick bandlike subepithelial collagen in gastric antral mucosa, focal superficial epithelial degeneration, numerous intraepithelial lymphocytes, and a dense lamina propria lymphoplasmacytic infiltrate. Image analysis evaluation of gastric antral biopsies demonstrated a mean thickness of subepithelial collagen of 27.07 micron. Morphologic comparison was made with age-matched control groups of 10 patients who had normal gastric mucosal biopsies and 10 patients who had "chronic" gastritis, which revealed mean subepithelial collagen measures of 1.37 micron and 1.19 micron, respectively. We compared these morphologic findings with those of all previous case reports of collagenous gastritis and propose a pathologic definition based on the limited combined data. It seems that subepithelial collagen is dramatically thickened in reported cases of collagenous gastritis, with a cumulative mean measure of 36.9 micron. It is also apparent from this and previous reports that the thickened subepithelial collagen is accompanied by a chronic or chronic active gastritis and sometimes intraepithelial lymphocytes and surface epithelial damage. Recently described associations of lymphocytic gastritis, sprue, and lymphocytic colitis as well as collagenous and lymphocytic colitis suggest a common pathogenesis that empirically may include collagenous gastritis in the same disease spectrum. We propose that collagenous gastritis can be confidently identified by using

  5. 中医药治疗慢性萎缩性胃炎临床随机对照试验文献方法学评价%Methodological appraisement of clinical trial literature in treatment of chronic atrophic gastritis

    Institute of Scientific and Technical Information of China (English)

    张竞之; 陈弼沧; 涂志红; 常艳杰

    2005-01-01

    目的:评价近5年来中医药治疗慢性萎缩性胃炎(CAG)的临床随机对照试验(RCT)方法学质量.方法:对从中国医学科学院的中国生物医学文献光盘,和中国中医研究院情报所的中医药科技文献数据库所检索出的中医药治疗CAG的所有69篇RCT文献,在诊断标准、纳入和排除标准、随机分组、各组基线可比性检验、样本含量及估算、分配隐匿、盲法运用、失访病例及意向性分析、统计方法、说明不良反应、干预措施、随访和疗效评价标准等方面进行评价.结果:近5年来中医药治疗CAG的RCT设计仍存在诸多问题.结论:中医药治疗CAG的RCT设计有待进一步规范.

  6. Clinical Observation of Chronic Gastritis Treated with Electroacupuncture at"Gastric Disorder Point Recipe"%电针腧穴"胃病方"治疗慢性胃炎的临床观察

    Institute of Scientific and Technical Information of China (English)

    田康康; 吉宏明; 王海军; 李圣云

    2013-01-01

    Objective To observe the clinical efficacy on chronic gastritis with electroacupuncture at" gastric disorder point recipe . Methods Sixty cases of chronic gastritis visited in the Digestive Internal Medicine Department of Shanxi People's Hospital were collected randomly from June 2011 to June 2012 and divided into two groups. In the control group, metronidazole was prescribed for oral administration,0. 4 g · time-1 ,twice a day;omeprazole enteric capsules,20 mg · time-1 ,twice a day. The session of treatment was 1 month and the medication was discontinued for half a month. Fiber gastroscopy was conducted. The clinical efficacy was evaluated by the improvements in clinical symptoms and fiber gastroscopy examination. In the treatment group, on the basis of the control group, the electroacupuncture was combined. The points were Zhongwan( CV12 ),Neiguan( PC6 )and Zusanli( ST36 ). Perpendicular insertion was done on the points. The needles were retained for 30min. The electric frequency was 30 Hz. The treatment of 10 days made 1 session. The efficacy assessment was done after 3 sessions of treatment. The assessment method was same as the control group. At the end of treatment, the efficacy was evaluated in each group and compared between two groups. Results The total effective rate of chronic gastritis was 93.4% in the treatment group and was 86. 7% in the control group,presenting the statistically significant difference in comparison( P <0. 05 ). Conclusion Electroacupuncture at"gastric disorder point recipe achieves the definite, safe and reliable efficacy on chronic gastritis. It deserves to be promoted in clinical practice.%目的 观察电针腧穴"胃病方"对慢性胃炎的临床疗效.方法 选取2011年6月~2012年6月于山西省人民医院消化内科就诊的60例慢性胃炎患者,将其随机分成两组,对照组口服甲硝唑0.4 g·次-1,日2次,奥美拉唑肠溶胶囊20 mg·次-1,日2次,1个月为1个疗程,服药后停药半个月,然后进

  7. Malignant atrophic papulosis (Köhlmeier-Degos disease) - A review

    OpenAIRE

    Theodoridis Athanasios; Makrantonaki Evgenia; Zouboulis Christos C

    2013-01-01

    Abstract Definition of the disease Malignant atrophic papulosis (MAP), described independently by Köhlmeier and Degos et al., is a rare, chronic, thrombo-obliterative vasculopathy characterized by papular skin lesions with central porcelain-white atrophy and surrounding teleangiectatic rim. Epidemiology Less than 200 cases have been described in the literature. The first manifestation of MAP usually occurs between the 20th and 50th year of life. Clinical description The cutaneous clinical pic...

  8. Collagenous gastritis: a morphologic and immunohistochemical study of 40 patients.

    Science.gov (United States)

    Arnason, Thomas; Brown, Ian S; Goldsmith, Jeffrey D; Anderson, William; O'Brien, Blake H; Wilson, Claire; Winter, Harland; Lauwers, Gregory Y

    2015-04-01

    Collagenous gastritis is a rare condition defined histologically by a superficial subepithelial collagen layer. This study further characterizes the morphologic spectrum of collagenous gastritis by evaluating a multi-institutional series of 40 patients (26 female and 14 male). The median age at onset was 16 years (range 3-89 years), including 24 patients (60%) under age 18. Twelve patients (30%) had associated celiac disease, collagenous sprue, or collagenous colitis. Hematoxylin and eosin slides were reviewed in biopsies from all patients and tenascin, gastrin, eotaxin, and IgG4/IgG immunohistochemical stains were applied to a subset. The distribution of subepithelial collagen favored the body/fundus in pediatric patients and the antrum in adults. There were increased surface intraepithelial lymphocytes (>25 lymphocytes/100 epithelial cells) in five patients. Three of these patients had associated celiac and/or collagenous sprue/colitis, while the remaining two had increased duodenal lymphocytosis without specific etiology. An eosinophil-rich pattern (>30 eosinophils/high power field) was seen in 21/40 (52%) patients. Seven patients' biopsies demonstrated atrophy of the gastric corpus mucosa. Tenascin immunohistochemistry highlighted the subepithelial collagen in all 21 specimens evaluated and was a more sensitive method of collagen detection in biopsies from two patients with subtle subepithelial collagen. No increased eotaxin expression was identified in 16 specimens evaluated. One of the twenty-three biopsies tested had increased IgG4-positive cells (100/high power field) with an IgG4/IgG ratio of 55%. In summary, collagenous gastritis presents three distinct histologic patterns including a lymphocytic gastritis-like pattern, an eosinophil-rich pattern, and an atrophic pattern. Eotaxin and IgG4 were not elevated enough to implicate these pathways in the pathogenesis. Tenascin immunohistochemistry can be used as a sensitive method of collagen detection. PMID

  9. Fatores associados com a gastrite crônica em pacientes com presença ou ausência do Helicobacter pylori Factors associated with chronic gastritis in patients with presence and absence of Helicobacter pylori

    Directory of Open Access Journals (Sweden)

    Lissa Chamse Ddine

    2012-06-01

    , doenças associadas e nutrição inadequada, interagem para o início das manifestações clínicas, e a presença ou ausência de H. pylori não mostrou diferenças significativas no estado clínico dos pacientes.BACKGROUND - Chronic gastritis is an inflammation of the stomach mucosa, which is considered its main etiological factor the Helicobacter pylori. AIM - To observe the differences in patients with chronic gastritis as well as the presence and absence of H. pylori, to obtain a better understanding of the etiological factors, clinical, dietary and lifestyle habits and associated diseases. METHODS - This was a descriptive study, retrospective medical records of patients with chronic gastritis treated as outpatients. Endoscopy and research of H. pylori was used in the diagnosis of chronic gastritis. The survey was conducted through a questionnaire to ascertain the risk factors for chronic gastritis and the clinical manifestations of disease, dietary and lifestyle habits, family history of the disease, weight changes and medications. For statistical analysis was used Spearman coefficient. Data were considered statistically significant p<0.05. RESULTS - Of the 94 patients evaluated were symptomatic with heartburn, belching, epigastric pain, fullness and nausea. In 56.6% (n = 54 of individuals was detected the presence of bacteria and in 43.6% (n = 40 was not found any specific etiologic factor. Was performed chi-square statistical test of clinical manifestations and factors such as stress and anxiety, leading to positive correlation. It became evident that the risk factors for disease are diverse, including the use of drugs, alcoholism, eating quickly, talking during meals, with significant relation to abdominal distension and reflux. The patients with the bacteria, had a higher risk of experiencing these symptoms. CONCLUSION - Various etiological factors in eating habits and lifestyle, as smoking, alcoholism, anxiety, stress, associated diseases and inadequate

  10. Collagenous gastritis associated with lymphocytic gastritis and celiac disease.

    Science.gov (United States)

    Stancu, M; De Petris, G; Palumbo, T P; Lev, R

    2001-12-01

    Collagenous gastritis is a rare disorder, with only 8 cases reported in the literature, 2 in children and 6 in adults. We report an additional case of collagenous gastritis in a 42-year-old man with celiac disease. A thickened (>10 microm) subepithelial collagen band with entrapped capillaries, fibroblasts, and inflammatory cells was seen in the stomach, associated with lymphocytic gastritis. The duodenal mucosa showed severe villous atrophy but no subepithelial collagen deposition. No evidence of lymphocytic or collagenous colitis was found in the colon. The patient became symptom-free on a gluten exclusion diet and showed partial improvement of histopathologic findings after 3 months. Collagenous gastritis is a rare disease, but a wider recognition of its histopathologic features and clinical associations may bring more cases to light and provide additional clues in determining its etiology and pathogenesis. PMID:11735694

  11. Helicobacter pylori-negative Russell body gastritis: Case report

    Institute of Scientific and Technical Information of China (English)

    Alessandro Del Gobbo; Luca Elli; Paola Braidotti; Franca Di Nuovo; Silvano Bosari; Solange Romagnoli

    2011-01-01

    Russell body gastritis is an unusual form of chronic gas-tritis characterized by the permeation of lamina propria by numerous plasma cells with eosinophilic cytoplasmic inclusions. Very few cases have been reported in the lit-erature; the majority of which have shown Helicobacter Pylori (H. pylori) infection, thus suggesting a correlation between plasma cell presence and antigenic stimulation by H. pylori. We present a case of Russell body gastritis in a 78-year-old woman who was undergoing esophago-gastroduodenoscopy for epigastric pain. Gastric biopsy of the gastroesophageal junction showed the presence of cells with periodic acid-Schiff-positive hyaline pink bodies. Giemsa staining for H. pylori infection was nega-tive, as well as immunohistochemical detection. The cells with eosinophilic inclusions stained positive for CD138, CD79a, and κ and lambda light chains, which confirmed plasma cell origin. In particular, κ and lambda light chains showed a polyclonal origin and the patient was negative for immunological dyscrasia. The histologi-cal observations were confirmed by ultrastructural ex-amination. The cases reported in the literature associated with H. pylori infection have shown regression of plasma cells after eradication of H. pylori. Nothing is known about the progression of H. pylori-negative cases. The unusual morphological appearance of this type of chron-ic gastritis should not be misinterpreted during routine examination, and it should be distinguished from other common forms of chronic gastritis. It is mandatory to exclude neoplastic diseases such as gastric carcinoma, lymphoma and plasmocytoma by immunohistochemistry and electron microscopy, which can help with differential diagnosis. The long-term effects of plasma cells hyper-activation are still unknown, because cases of gastric tu-mor that originated in patients affected by Russell body gastritis have not been described in the literature. We are of the opinion that these patients should be

  12. 慢性浅表性胃炎肝胃不和证中药用药频次统计%TCM Medication Frequency Statistics for the Patients with Chronic Superficial Gastritis of Liver-stomach Disharmony Pattern

    Institute of Scientific and Technical Information of China (English)

    余钦; 徐进康

    2014-01-01

    Objective:To summarize and analyze medication frequency and the features of herbs in treating chronic superficial gastritis of liver-stomach disharmony pattern. Methods:The prescriptions for chronic superficial gastritis of liver-stomach disharmony pattern were searched in medical journals in recent ten years to count the fre-quency of different herbs in the prescriptions. Results:All 24 pieces of articles were included, 13 kinds of formulae (containing classical prescriptions and personal empirical prescriptions) in all, altogether 91 kinds of herbs, medica-tion cumulative frequency reached to 1 333 times. Conclusion: ChaiHu ShuGan powder is of the highest frequency;the drugs of liver-soothing Qi-regulating occupies the half of 15 kinds of drugs and they reached 37% of all the drugs, the next are the drugs of tonification (17%), of blood-activating (11%), of heat-clearing (7%) and of diges-tion-promoting (7%).%目的:归纳分析中药治疗慢性浅表性胃炎肝胃不和证的用药频次及特点。方法:检索近10年来各类医学期刊,获取治疗慢性浅表性胃炎肝胃不和证的各类方剂,统计方剂中不同中药的使用频次。结果:共有24篇文献被纳入研究,合计13类方剂(包括经方和个人经验方),共计91味中药,用药累积频数1333次。结论:柴胡疏肝散使用最频;疏肝理气药用药占前15味药中的一半,占总药物中的百分比为37%,其次是补益药(17%)、活血药(11%)、清热药(7%)、消食药(7%)。

  13. 柴胡疏肝散治疗慢性浅表性胃炎30例临床观察%Clinical Observation of 30 Cases of Chronic Superficial Gastritis Treated with Chaihu Shugan Powder

    Institute of Scientific and Technical Information of China (English)

    李庐娟

    2012-01-01

      objective To observe the clinical effect of chaihu shugan powder on chronic superficial gas-tritis. Methods 57 cases were divided randomly into two groups. 30 cases in treatment group were treated with chaihu shugan powder.27 cases in control group were treated with omeprazole.4 weeks of treatment made one session in either group. The clinical efficacy and changes in clinicaI symptoms were observed in two groups after 1 session treatment. Results In treatment group, the total effective rate was 96.7% .In control group, the total effective rate was 88.9% .The significant statistical difference presented in comparison of two groups(P<0.05).Moreover, the improvements in clinical symptoms were apparent in treatment group as compared with control group. Conclusion Chaihu shugan powde has quite advantageous clinical efficacy on chronic superficial gastritis.%  目的观察柴胡疏肝散治疗慢性浅表性胃炎的临床疗效.方法将57例患者随机分为两组,治疗组30例,采用口服柴胡疏肝散,对照组27例给予奥美拉唑,两组均以4周为1个疗程.1个疗程后观察两组患者的临床疗效及临床症状变化情况.结果治疗组总有效率为96.7%;对照组总有效率为88.9%.两组比较,差异有统计学意义(P <0.05),且治疗组较对照组临床症状有明显改善.结论柴胡疏肝散对慢性浅表性胃炎有较好的临床疗效.

  14. Macrophages Are Mediators of Gastritis in Acute Helicobacter pylori Infection in C57BL/6 Mice▿

    OpenAIRE

    Kaparakis, Maria; Walduck, Anna K.; Price, Jason D.; Pedersen, John S; van Rooijen, Nico; Pearse, Martin J.; Wijburg, Odilia L. C.; Strugnell, Richard A.

    2008-01-01

    Helicobacter pylori is the etiological agent of human chronic gastritis, a condition seen as a precursor to the development of gastrointestinal ulcers or gastric cancer. This study utilized the murine model of chronic H. pylori infection to characterize the role of macrophages in the induction of specific immune responses and gastritis and in the control of the bacterial burden following H. pylori infection and vaccination. Drug-loaded liposomes were injected intravenously to deplete macropha...

  15. Clinical pathology of primary bile reflux gastritis

    Directory of Open Access Journals (Sweden)

    Ping YAO

    2011-05-01

    Full Text Available Objective To analyze the clinical and pathological features of primary bile reflux gastritis(BRG.Methods Endoscopy,Helicobacter pylori(H.pylori detection,and histopathologic examination were performed in 218 patients with primary BRG(observed group and 236 patients with simple chronic gastritis(SCG,control group as identified by gastroscope in order to analyze the endoscopic abnormalities,the frequency of H.pylori infection,pathological features and scores of inflammation.Results The frequency of H.pylori infection was 39.0%(85/218 in the observed group,which was significantly lower than that in the control group [52.1%(123/236].The topographic abnormalities of the antral mucosa as detected by gastroscopy,i.e.,congestion,hemorrhagic spots,erosion were not significantly different between BRG and SCG patients(P > 0.05.The scores of chronic and active inflammation were higher in patients when H.pylori infection was present than in patients without H.pylori infection in both groups(P < 0.05.The scores of inflammation,the detection rates of the antral intestinal metaplasia,antral atrophy and atypical hyperplasia were all higher in observed group than in control group(P < 0.05.The incidence of lengthening of gastric pits,telangiectasis or interstitial edema in BRG patients was also significantly higher than those in SCG patients(P < 0.05.Conclusions Primary BRG shows features of chemical gastritis with a higher tendency toward mucosal atrophy,intestinal metaplasia and atypical hyperplasia.Gastropic examination and biopsy should be emphasized.

  16. Effective Treatments of Atrophic Acne Scars

    OpenAIRE

    Gozali, Maya Valeska; ZHOU, BINGRONG

    2015-01-01

    Atrophic scarring is often an unfortunate and permanent complication of acne vulgaris. It has high prevalence, significant impact on quality of life, and therapeutic challenge for dermatologists. The treatment of atrophic acne scars varies depending on the types of acne scars and the limitations of the treatment modalities in their ability to improve scars. Therefore, many options are available for the treatment of acne scarring, including chemical peeling, dermabrasion, laser treatment, punc...

  17. Surviving Emphysematous Gastritis after Hepatectomy

    Directory of Open Access Journals (Sweden)

    Harry Hok Yee Yu

    2013-01-01

    Full Text Available Emphysematous gastritis is a rare variant of phlegmonous gastritis due to invasion of stomach wall by gas-forming bacteria. It is characterised by abnormal presence of gas in the stomach by imaging, in association with clinical sepsis. Patients suffering from this condition usually present with an underlying pathology. We are reporting a middle-aged Chinese male with hepatitis B virus related hepatocellular carcinoma. He underwent partial hepatectomy and was diagnosed with emphysematous gastritis 4 days after index operation. Emergency laparotomy, including upper endoscopy, was performed. He was managed with antibiotics and discharged 18 days after second operation. This paper shows a review of the literature about the disease, with particular attention to pathology, clinical features, and management.

  18. Topographic mapping of collagenous gastritis.

    Science.gov (United States)

    Freeman, H J

    2001-07-01

    A 74-year-old woman was investigated for abdominal pain and diarrhea. Endoscopic examinations including biopsies of the stomach and colon demonstrated the typical subepithelial deposits characteristic of collagenous gastritis and collagenous colitis. Histochemical and ultrastructural methods confirmed the presence of collagen in the subepithelial deposits. The topographic distribution of these collagen deposits and their relationship to the inflammatory process in the stomach were then defined by endoscopic mapping and multiple site biopsies of the mucosa in the gastric body and antrum. These studies indicate that collagenous gastritis not only is distinctive, but also is a far more extensive and diffuse inflammatory process than has previously been appreciated. PMID:11493952

  19. [Classification of gastroesophageal reflux disease and gastritis].

    Science.gov (United States)

    Vukobrat-Bijedic, Zora

    2002-01-01

    The gastroesophageal reflux disease (GORD) is frequent and causes by retrograde flow of the gastric content through incompetent gastroesophageal junction. Epidemiological studies have proved that GORD is associated with hearburn in high prevalence. In western countries several studies reported that 20-40% of adult population experience heartburn symptoms at least once in the year, approximately 10% have symptoms weekly and 5% daily. Esophagitis was objectively defined as a mucosal damage and it was endoscopically verificated in 25% of patients. Indeed, GORD symptoms and esophagitis are in poor correlation and less than half of patients with heartburn symptoms had esophagitis on endoscopy. From 1989, Savary Monniér and Metaplasia-Ulcer-Stricture-Erosion (MUSE) endoscopically classification is in use. From 1994, LA (Los Angeles) classification of reflux disease is also in use by endoscopists. During its life cycle, gastric mucosa is exposed to different harmful agents and its response is restitution "ad integrum" on the beginning and at the end of process. First line defence is mucuse barrier which prevent contact between epithelial cell and possible irritant. Important role in mucuse layer plays prostaglandins. After several classification systems previously used, in 1991 Price introduced Sydney system gradation and gastritis classification. Pointing out importance of topographical differences in gastritis distribution, system has introduced 5 histological variations in its Morphological section: chronic inflammation, neutrophylic activity, glandular atrophy, intestinal metaplasy and H. pylori colonisation, with 4 points grading. PMID:12055715

  20. Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta2 microglobulin transgenic rats.

    OpenAIRE

    Rath, H C; Herfarth, H H; Ikeda, J S; Grenther, W B; Hamm, T E; Balish, E; Taurog, J D; Hammer, R. E.; Wilson, K H; Sartor, R B

    1996-01-01

    Genetic and environmental factors are important in the pathogenesis of clinical and experimental chronic intestinal inflammation. We investigated the influence of normal luminal bacteria and several groups of selected bacterial strains on spontaneous gastrointestinal and systemic inflammation in HLA-B27 transgenic rats. Rats maintained germfree for 3-9 mo were compared with littermates conventionalized with specific pathogen-free bacteria. Subsequently, germfree transgenic rats were colonized...

  1. Association of Helicobacter pylori infection with nodular antritis and follicular gastritis

    Directory of Open Access Journals (Sweden)

    Tomašević Ratko

    2006-01-01

    Full Text Available Introduction. Helicobacter pylori (H. pylori infection is known to be the must common cause of chronic gastritis having some endoscopic and pathologic characteristies as determinated by the Sydney System for Gastritis Classification. The aim of our case report was to point out the relationship between an endoscopic finding of nodular antritis and the presence of H. pylori infection and active chronic gastritis. Case report. Our patient underwent upper gastrointestinal endoscopy for dyspeptic complaints and was diagnosed as having nodular antritis, but also underwent urease test and hystopathologic examination of antral mucosa, to determine the presence and density of H. pylori infection and the presence and severity of gastritis. After a course of anti H. pylori treatment, dyspepsia improved and new biopsy specimens obtained two months and six months afterwards revealed no pathological findings. Conclusion. The case report supported the association of H. pylori infection of lymphoid follicles with nodular gastric mucosis.

  2. Clinical Study on Chronic Gastritis Treated by Methods of Replenishing qi,Activating Spleen and Eliminating Blood Stasis%益气健脾化瘀法治疗慢性胃炎临床研究

    Institute of Scientific and Technical Information of China (English)

    刘俊峰; 何高潮

    2012-01-01

    目的:探讨益气健脾化瘀法治疗慢性胃炎的疗效.方法:将90例患者随机分为两组.治疗组60例采用益气健脾化瘀法治疗,药用丹参、檀香、砂仁、党参、白术、茯苓、枳壳、厚朴、黄连、吴茱萸、百合、乌药、甘草治疗.对照组30例采用法莫替丁片合果胶铋胶囊治疗.结果:治疗组痊愈28例,显效12例,有效17例,无效3例,有效率95.00%;对照组痊愈8例,显效11例,有效6例,无效5例,有效率83.00%;两组有效率比较差异有显著性意义(P<0.05),治疗组疗效优于对照组.结论:益气健脾化瘀法治疗慢性胃炎疗效满意.%Objective:To discuss the therapeutic effects of the method of replenishing qi, activating spleen and eliminating blood stasis on the treatment of chronic gastritis. Methods:90 cases were randomly divided into two groups. The treatment group(60 cases) was treated by methods of replenishing qi,activating spleen and eliminating blood stasis,and the Chinese herbs were Danshen( Radix Salvia Miltior-rhiza) ,Tanxiang(Sandalwood) ,Sharen( Fructus amomi) ,Dangshen(Codonopsis pilosula) , Baizhu( White Atractylodes Rhizome) , Ful-ing(Poria) ,Zhiqiao(Fructus aurantii immaturus ) , Houpo ( Mangnolia officinalis ), Huanglian ( Goldthread ), Wuzhuyu ( Fructus evodi-ae) ,Baihe(Lily) ,Wuyao( Radix Linderae) , Gancao(liquorice). The control group(30 cases) was treated by Famotidine Tablets and Colloidal Bismuth Pectin Capsules. Results:In the treatment group,28 cases were cured, 12 achieved excellent effects, 18 were effective, 3 were ineffective and the effective rate was 95% ;in the control group,8 cases were cured, 11 achieved excellent effects,6 were effective,5 were ineffective and the effective rate was 83%. Comparison of the total effective rates between two groups showed that the difference had notable significance(P <0.05) ,and the curative effects of the treatment group was superior to the control group. Conclusion: The methods of

  3. 中西药治疗幽门螺杆菌阳性慢性胃炎Meta分析%Meta analysis of Chinese and Western medicine treatment of Helicobacter pylori positive chronic gastritis

    Institute of Scientific and Technical Information of China (English)

    李钢; 梁韶春; 张玉梅; 李腾娇; 侯国娜; 梁丽丽

    2014-01-01

    目的:收集2000-2012年国内外治疗幽门螺杆菌(Hp)阳性慢性胃炎文献,分析对比疗效。方法:查寻CENTRAL、NTIS和CNKI、VIP文库,纳入随机对照试验。结果:阿莫西林(或痢特灵)加克拉霉素和雷贝拉唑三联贯序治疗Hp根治率达74.2%,如配合蒲元和胃或荆花胃康以及大蒜素之一,根治率达81.6%。结论:单用一种或两种杀幽门螺杆菌药物,疗效低,耐药机会普遍,中西药联合三或四联疗法值得推荐。%Objective:We collected the literature of domestic and foreign treatment of Helicobacter pylori positive chronic gastritis from 2000 to 2012,and to compare the efficacy.Methods:We searched for CENTRAL,NTIS and CNKI,VIP library. Literature were enrolled in a randomized controlled trial.Results:The curative rate of triple sequential treatment of Hp of amoxicillin(or furazolidone) plus clarithromycin and ray Bella was 74.2%.If Pu Yuan He Wei or Jing Hua Wei Kang and Allicin was added,the cure rate can reach 81.6%.Conclusion:The efficacy of application of single or two of killing Helicobacter pylori drugs is low,and the resistance opportunity is universal.Combination of Chinese and Western medicine in three or quadruple therapy is recommended.

  4. Data Analysis and Quality Assessment on the Studies of Traditional Chinese Medicine for Chronic Gastritis%慢性胃炎中医药研究文献的数据分析及质量评价研究

    Institute of Scientific and Technical Information of China (English)

    李敬华; 封毅; 罗良涛

    2013-01-01

    Objective:To assess the quality of published randomized controlled trials on traditional Chinese medicine ( TCM) treating chronic gastritis .Methods:Studies on treating chronic gastritis with the terms of “random” or“randomized”,“randomized controlled”published form 1999 to 2008 were retrieved on CNKI and VIP .Results: Among the retrieved 1088 studies, 12 non-randomized ones were excluded , and the remaining 1076 papers were accorded with the inclusion criteria .1) There were only 119 articles describing the allocation method, and the appropriate allocation method was described in 64 of them.2) Only 3 articles described allocation conceal-ment, and two of them adopted sufficient allocation concealment .3) Four studies mentioned the blind method of intervention , and two of them studies noted double-blind.4) Five studies reported the number of unfinished cases , and only one study finished intention-to-treat. 5) There were altogether 351 literatures reporting selective results , and 725 ones were non-selective results report .6) There were only 22 articles without the problems which would lead studies to be at risk .Conclusion:Till now, it was lack of high-quality RCT literatures in the clinical research of chronic gastritis treated with TCM , therefore, the overall level of Chinese medicine clinical researches needs to be improved.RCT has not been truly used in Chinese medicine clinical research .%目的:评价我国关于中医药治疗慢性胃炎的临床随机对照试验文献的质量。方法:检索中国知网( CNKI)、中文科技期刊数据库( VIP),纳入凡文中有“随机”字样或“随机分组”“随机对照”的慢性胃炎为目标疾病的研究,并对其质量进行评价,检索年限从1999年至2008年。结果:共检索出1088篇文献,其中排除非随机对照文献12篇,将1076篇文献纳入分析。1)仅有119篇文献说明了分配序列产生的方法,而其中分配

  5. 基于文本挖掘技术分析中成药、西药对慢性胃炎的治疗规律%Based on Text Mining Techniques to Explore Medication Regularity of Chinese Patent Medicine and West Medicine Application for Chronic Gastritis

    Institute of Scientific and Technical Information of China (English)

    李立; 周奇; 郑光; 郭洪涛; 吕爱平

    2011-01-01

    Objectine; To analyze the regularity of Chinese patent medicine and west medicine application for chronic gastritis with text mining technique. Method; Collected large literature about treatment against chronic gastritis in CBM (Chinese Bio Medical Literature Database). Then, We transfer XML type data sets to the structured database of Microsoft? SQL? And visualize them into different graphs by Excel and Cytoscape software. Result; Sini San, Lizhong Wan were the commonly used Chinese patent medicine. The high frequencies of west medicine against chronic gastritis were amoxicillin, omeprazole and clarithromycin. Chinese patent medicine Sini San as well as west medicine omprazde and ranitidine of the combinated with othor drugs in treatment of the chronic gastrits. Conclusion: The text mining technology can find the medication regularity of Chinese patent medicine and west medicine application for chronic gastritis.%目的:利用文本挖掘技术探索中成药、西药对慢性胃炎的治疗规律.方法:在中国生物医学文献数据库(CBM)中收集治疗慢性胃炎的相关文献,建立Access数据库,运用SQL对数据进行处理,结合人工降噪,分析中成药、西药对再障的治疗用药规律.结果:四逆散、理中丸等为中成药治疗慢性胃炎文献中出现的高频药物,阿莫西林、奥美拉唑、克拉霉素等为西药治疗慢性胃炎文献中出现的高频药物,在药物联合应用方面,中药四逆散、西药雪尼替丁和奥美拉唑出现频率较高.结论:利用文本挖掘技术可以从海量的中成药文献中发现治疗慢性胃炎的用药规律,协助规范中西医联合治疗方案.

  6. Tnterobserver variation in histopathological assessment of Helicobacter pylori gastritis

    Institute of Scientific and Technical Information of China (English)

    Ozlem Aydin; Reyhan Egilmez; Tuba Karabacak; Arzu Kanik

    2003-01-01

    Because the presence or absence of H pylori infection has important implications for therapeutic decisions based on histological assessment, the reproducibility of Sydney system is important. The study was designed to test the reproducibility of features of Helicobacter pylori gastritis,using the updated Sydney classification.METHODS: Gastric biopsies of 40 randomly selected cases of Hpylori gastritis were scored semiquantitatively by three pathologists. Variables analysed included chronic inflammation,inflammatory activity, atrophy, intestinal metaplasia, H pylori,surface epithelial damage. Κ values below 0.5 represented poor, those between 0.5 and 0.75 good and values over 0.75excellent interobserver agreement.RESULTS: The best interobserver agreement (κ=0.62) was present for intestinal metaplasia. The agreement was the poorest for evaluating atrophy (κ=0.31).CONCLUSION: Although the results of this study were in accordance with some previous studies, an excellent agreement could not be reached for any features of H pylori gastritis. This low degree of concordance is assumed to be due to the personal evaluation differences in grading the features, the lack of standardized diagnostic criteria, and the ignorance to reach a consensus about the methods to be used in grading the features of H pylori gastritis before initiating the study.

  7. Topographic Mapping of Collagenous Gastritis

    OpenAIRE

    Hugh J Freeman

    2001-01-01

    A 74-year-old woman was investigated for abdominal pain and diarrhea. Endoscopic examinations including biopsies of the stomach and colon demonstrated the typical subepithelial deposits characteristic of collagenous gastritis and collagenous colitis. Histochemical and ultrastructural methods confirmed the presence of collagen in the subepithelial deposits. The topographic distribution of these collagen deposits and their relationship to the inflammatory process in the stomach were then define...

  8. Ethnic difference of Helicobacter pylori gastritis: Korean and Japanese gastritis is characterized by male- and antrum-predominant acute foveolitis in comparison with American gastritis

    Institute of Scientific and Technical Information of China (English)

    Inchul Lee; Hojung Lee; Mijung Kim; Manabu Fukumoto; Shinji Sawada; Shriram Jakate; Victor E. Gould

    2005-01-01

    AIM: To investigate the clinicopathological factors underlying the ethnic differences of Helicobacter pylori gastritis and cancer.METHODS: We analyzed clinicopathological parameters of gastric biopsies having H pylori infection that were randomly selected from different ethnic populations including 147 Americans, 149 Japanese, and 181 Koreans.RESULTS: Males were predominant in Japanese and Korean populations (77.9 and 67.4% respectively) in comparison with Americans (48.3%) (P<0.001). H pylori gastritis in Koreans and Japanese was characterized by the predominant antral involvement. In the antrum,neutrophilic infiltration into the proliferative zone of pit, i,e.acute foveolitis, was more frequent in Koreans (82%) than in Japanese (71%) (P<0.05) and Americans (61%) (P<0.001).Interstitial neutrophilic infiltration, intestinal metaplasia and atrophy were also frequent in Koreans and Japanese. In the body, the prevalence of acute foveolitis was not significantly different among the populations while chronic interstitial inflammation and lymphoid follicles were more pronounced in the body of Americans than in the body of others (P<0.01).CONCLUSION: The male-, and antrum-predominant Hpylori gastritis in Koreans and Japanese is compatible with the pattern of sex and topographical distribution of gastric cancer incidence. Our data suggest that persistent acute foveolitis at the proliferative zone is a crucial step in the gastric carcinogenesis.

  9. H.heilmannii与H.pylori相关性胃炎的对比研究%A comparative study of H.heilmannii-associated and H. pylori-associated gastritis

    Institute of Scientific and Technical Information of China (English)

    李静; 陈烨; 周永柏; 付祥胜; 王继德; 陈楚弟; 张亚历

    2008-01-01

    Objective To evaluate the clinical manifestations, endoscopic features and the clinical pathological characteristics of H. heilmannii-associated gastritis, and to compare these variables with those of H. pylori-ussociated gastritis. Methods The clinical data, endoscopic findings and pathologic characteristics of 3107 patients, who underwent endoscopy from 2005 to 2007, were retrospectively analyzed. Results Twenty-five cases of H. heilmannii infection were identified, the infection rates of H. heilmannii and H. pylori were 0.80% (25/3107) and 4.12% (1060/3107) respectively. Three cases were mixed infections. Of 25 patients, 20 showed such gastroenterologic symptoms to a greater or less extent as abdominal distending pain,nausea and anorexia, and other 5 cases were asymptomatic. All 25 patients showed chronic gastritis by en-doscopy, including chronic superficial gastritis (7/25, 28% ), erosion ( 3/25, 12% ), chronic atrophic gastritis (4/25, 16%), bile reflux(1/25, 4%), ulcer (1/25, 4%), polyp (1/25, 4%) and duodenal bulbar inflammation (2/25, 8% ). In rapid urease test, 3 cases were hyper-positive, 3 cases positive, 7 ca-ses mild-positive and 12 cases negative. According to histological observation, H. heilmannii scattered or ac-cumulated within the gastric pits, glandular lumen or mucus. The organism was observed in parietal cells with cell damage in one case. Sporadic lymphatic and plasmic infiltration were found in all patients with H.heilmannii infection, infiltration of neutrophils (12/25), gland atrophy and intestinal metaplasia (4/25)and lymphoid follicles (6/25) were also observed. Compared with H. pylori-associated gastritis, H. heilman-nii-associated gastritis showed less inflammation, less helicobacter density, mononuclear cell infiltration and neutrophilic activity ( P < 0.05 ). Conclusion H. heilmanaii mainly induces chronic gastritis, which is less severe than H. pylori-associated gastritis.%目的 评估上消化道H.heilmannii感染的临床表现

  10. Dominant cagA/vacA genotypes and coinfection frequency of H. Pylori in peptic ulcer or chronic gastritis patients in Zhejiang Province and correlations among different genotypes, coinfection and severity of the diseases

    Institute of Scientific and Technical Information of China (English)

    CHEN Xue-jun; YAN Jie; SHEN Yue-fang

    2005-01-01

    Background Almost half of the world's population suffer from the Helicobacter pylori (H. Pylori) infection, but only some individuals develop gastric diseases with clinical symptoms. One reason for the phenomenon may be the different pathogenicity of infected H. Pylori strains. The presence of cytotoxin-associated gene A (cagA) and expression of vacuolating cytotoxin activity encoded by vacuolating cytotoxin gene A (vacA) are considered the two major virulent markers of H. Pylori. The aim of this study was to detect dominant cagA/vacA genotypes and coinfection frequency of H. Pylori in patients with peptic ulceration (PU) or chronic gastritis (CG), and to determine correlations among different cagA/vacA genotypes, coinfection and severity of the diseases. Methods For each of 139 patients in Zhejiang Province who had been diagnosed as PU or CG based on clinical symptoms and gastroscopy, two gastric biopsy specimens (one from antrum and the other from corpus) for H. Pylori isolation were taken by two different disinfected biopsy forceps. One hundred and fifty-six H. Pylori strains were isolated from both the antrum and corpus biopsy specimens of 78 patients (36 PU and 42 CG). PCRs were performed to detect cagA genes, and signal (s) and middle (m) regions of vacA genes in the H. Pylori isolates. The amplified fragments of dominant vacA gene s and m subtypes from representative H. Pylori isolates were sequenced after TA cloning. Dominant cagA/vacA genotypes of the H. Pylori isolates, coinfection frequency and correlations among the different genotypes, coinfection and severity of the diseases were determined.Results Of the H. Pylori strains isolated from the antrum specimens, 96.2% were cagA gene positive, as were 97.4% of the H. Pylori strains isolated from the corpus specimens. Only one s region subtype (s1a) and four m region subtypes m1, m2, m1b and m1b-m2 of vacA gene were found. The proportions of vacA gene subtypes s1a/m1, s1a/m2, s1a/m1b and s1a/m1b-m2 in the

  11. Atrophic-appearing Pancreas on Magnetic Resonance Cholangiopancreatography as Initial Presentation of Cystic Fibrosis

    OpenAIRE

    Stratton, Amy; Murphy, Thomas; Laczek, Jeffrey

    2012-01-01

    Cystic fibrosis is an autosomal recessive disease typically diagnosed in early childhood secondary to pulmonary manifestations. We present the unusual case of a 20-year-old man being diagnosed with cystic fibrosis after he was incidentally noted to have an atrophic pancreas on magnetic resonance cholangiopancreatography. He had no sign of chronic pancreatitis or symptoms of exocrine pancreatic insufficiency. As pancreatic atrophy is rare in young adults, the patient was evaluated for cystic f...

  12. Gastritis

    Science.gov (United States)

    ... with a bacteria called Helicobacter pylori Less common causes are: Autoimmune disorders (such as pernicious anemia) Backflow of bile into the stomach (bile reflux) Cocaine abuse Eating or drinking caustic or corrosive substances (such as ...

  13. Gastritis

    Science.gov (United States)

    ... hands with soap and water after using the bathroom and before eating eat food that has been ... La Información de la Salud en Español Health Statistics Healthy Moments Radio Broadcast Clinical Trials For Health ...

  14. Increased expression of intranuclear matrix metalloproteinase 9 in atrophic renal tubules is associated with renal fibrosis.

    Directory of Open Access Journals (Sweden)

    Jen-Pi Tsai

    Full Text Available BACKGROUND: Reduced turnover of extracellular matrix has a role in renal fibrosis. Matrix metalloproteinases (MMPs is associated with many glomerular diseases, but the histological association of MMPs and human renal fibrosis is unclear. METHODS: This is a retrospective study. Institutional Review Board approval was obtained for the review of patients' medical records, data analysis and pathological specimens staining with waiver of informed consents. Specimens of forty-six patients were examined by immunohistochemical stain of MMP-9 in nephrectomized kidneys, and the association of renal expression of MMP-9 and renal fibrosis was determined. MMP-9 expression in individual renal components and fibrosis was graded as high or low based on MMP-9 staining and fibrotic scores. RESULTS: Patients with high interstitial fibrosis scores (IFS and glomerular fibrosis scores (GFS had significantly higher serum creatinine, lower estimated glomerular filtration rate (eGFR, and were more likely to have chronic kidney disease (CKD and urothelial cell carcinoma. Univariate analysis showed that IFS and GFS were negatively associated with normal and atrophic tubular cytoplasmic MMP-9 expression and IFS was positively correlated with atrophic tubular nuclear MMP-9 expression. Multivariate stepwise regression indicated that MMP-9 expression in atrophic tubular nuclei (r = 0.4, p = 0.002 was an independent predictor of IFS, and that MMP-9 expression in normal tubular cytoplasm (r = -0.465, p<0.001 was an independent predictor of GFS. CONCLUSIONS: Interstitial fibrosis correlated with MMP-9 expression in the atrophic tubular nuclei. Our results indicate that renal fibrosis is associated with a decline of MMP-9 expression in the cytoplasm of normal tubular cells and increased expression of MMP-9 in the nuclei of tubular atrophic renal tubules.

  15. 慢性萎缩性胆囊炎采用腹腔镜胆囊切除术治疗的临床价值探析%Analysis of Clinical Curative Value of the Treatment of Chronic Atrophic Cholecystitis With Laparoscopic Cholecystectomy

    Institute of Scientific and Technical Information of China (English)

    靳洪申

    2015-01-01

    目的:探讨慢性萎缩性胆囊炎采用腹腔镜胆囊切除术治疗的临床价值。方法本次医学研究选择我院2011年1月~2014年12月之间收治的200例慢性萎缩性胆囊炎患者为观察对象,将其分为对照组和实验组,对照组接受常规开腹手术治疗,实验组接受腹腔镜胆囊切除术治疗,回顾分析两组患者临床治疗效果。结果两组观察对象并发症发生率对比无明显的统计学差异(P>0.05);实验组术后腹腔引流量、术中出血量、手术时间均少于对照组(P0.05). The abdominal cavity drainage flow,bleeding volume and operation time in experimental group were less than in control group(P<0.05). Conclusion By the medical research results,Laparoscopic cholecystectomy is a more effective clinical treatment of chronic atrophic cholecystitis.

  16. Emphysematous gastritis: case report and literature review

    International Nuclear Information System (INIS)

    Emphysematous gastritis is a rare form of gastritis that results from infection of the stomach wall by gas-forming organisms. Diagnosis of this commonly fatal condition rests on radiological demonstration of gas within the stomach wall. This can be observed on plain radiographs or CT scans of the abdomen. Only by prompt diagnosis and treatment can mortality be avoided. A new case of empysematous gastritis, diagnosed on CT scan by the demonstration of both intramural and portal venous gas, is presented and the literature is reviewed. Copyright (2001) Blackwell Science Pty Ltd

  17. Exploration on Proteomics of Tongue Coating in Patients with Chronic Gastritis of Spleen-asthenia and Damp-heat Syndrome%慢性胃炎脾虚湿热证患者的舌苔蛋白质组学初探

    Institute of Scientific and Technical Information of China (English)

    刘晓谷; 蔡淦; 何磊; 程亚伟; 王文静; 王忆勤

    2012-01-01

    目的:比较慢性胃炎脾虚湿热证患者与正常志愿者舌苔蛋白质谱的差异,筛选慢性胃炎脾虚湿热证的特征性舌苔蛋白标志物,并建立特征性舌苔的诊断模型.方法:收集30例慢性胃炎脾虚湿热证患者(实验组)和30例正常志愿者(正常组)的舌苔,经表面增强激光解析离子化飞行时间质谱( SELDI-TOF-MS)检验并筛选舌苔蛋白标志物,经生物信息学分析建立预测模型.结果:在质荷比1 000~15000范围内检测到189个差异蛋白峰.与正常组相比,实验组的差异蛋白质谱峰表达值较高(P<0.05);通过聚类分析,两组蛋白质谱峰值显示的聚类性质明显不同;利用主成分分析,两组舌苔样本的分布有明显差异,可有效分离;构建的慢性胃炎脾虚湿热证特征性舌苔诊断模型预测正确率为91.67%,灵敏度为100.00%,特异性为83.33%.结论:本研究所构建的特征性舌苔诊断模型能对慢性胃炎脾虚湿热证做出较为准确的判断,可为慢性胃炎脾虚湿热证的临床诊断提供一定的客观依据.%Objective: To compare the differences of protein spectrum of tongue coating between patients with chronic gastritis of spleen-asthenia and damp-heat syndrome and healthy volunteers, filter the characteristic protein markers of tongue coating in patients with chronic gastritis of spleen-asthenia and damp-heat syndrome, and establish the characteristic diagnosis model of tongue coating. Methods: The tongue coating of thirty patients with chronic gastritis of spleen-asthenia and damp-heat syndrome ( experimental group) and thirty healthy volunteers (normal group) was collected, the protein markers of tongue coating were filtered by surface enhanced laser desorption ionization time of flight mass spectrometry (SELDI-TOF-MS), and the prediction model was established by bioinformatics analysis. Results; There were 189 different protein peaks in the range of 1 000 to 15 000 of mass-to-charge ratio

  18. Analysis of treatment of 126 cases of chronic gastritis and peptic ulcer with positive helicobacter pylori%慢性胃炎、消化性溃疡、幽门螺杆菌阳性治疗分析126例

    Institute of Scientific and Technical Information of China (English)

    孟定德

    2014-01-01

    Chronic gastritis and peptic ulcer are common digestive system diseases in clinic.The treatment of the disease is mainly the eradication of helicobacter pylori infection.The treatment options are diverse.In this paper,2 kinds of treatment regimen for helicobacter pylori are compared to guide the clinical work.%慢性胃炎以及消化性溃疡在临床上是较为常见的消化系统疾病,在针对该病的治疗上主要是根除幽门螺杆菌感染,其治疗方案多种多样。本文就两种治疗幽门螺杆菌方案进行比较,以期望对临床工作有所指导。

  19. Overdenture locator attachments for atrophic mandible.

    Science.gov (United States)

    Mahajan, Neerja; Thakkur, Rahul K

    2013-10-01

    Implant-supported overdentures provide a good opportunity for dentists to improve oral health and quality-of-life of patients. Atrophic mandible poses a significant challenge to successful oral rehabilitation with dental implants. In this article, the fabrication of lower overdenture by two narrow platform implants is described with dual retentive, resilient, self-locating locator attachment system. The locator attachment system has the lowest profile in comparison with the ball and bar attachments and is versatile up to 40° of divergence between two implants. By using locators as attachments, we can meet functional, economic and social expectation of patients with ease and satisfaction.

  20. Overdenture locator attachments for atrophic mandible

    Directory of Open Access Journals (Sweden)

    Neerja Mahajan

    2013-01-01

    Full Text Available Implant-supported overdentures provide a good opportunity for dentists to improve oral health and quality-of-life of patients. Atrophic mandible poses a significant challenge to successful oral rehabilitation with dental implants. In this article, the fabrication of lower overdenture by two narrow platform implants is described with dual retentive, resilient, self-locating locator attachment system. The locator attachment system has the lowest profile in comparison with the ball and bar attachments and is versatile up to 40΀ of divergence between two implants. By using locators as attachments, we can meet functional, economic and social expectation of patients with ease and satisfaction.

  1. Collagenous gastritis associated with lymphocytic colitis.

    Science.gov (United States)

    Groisman, G M; Meyers, S; Harpaz, N

    1996-03-01

    Collagenous sprue and collagenous colitis are two well-recognized idiopathic enteritides whose defining histologic attribute is fibrous thickening of the subepithelial basement membrane. Analogous changes in gastric mucosa seem to be quite rare. The term "collagenous gastritis" was recently applied for the first time to an isolated case of refractory gastritis in which distinctive subepithelial gastric fibrosis was noted. We report an additional case of this entity in a 35-year-old woman with refractory dyspepsia. In contrast to the earlier case of collagenous gastritis, our patient also had lymphocytic colitis, a type of colitis associated with watery diarrhea. Collagenous gastritis appears to be a distinct clinicopathologic entity, the histologic changes of which should be sought in patients with unexplained dyspepsia. Increased awareness of this condition and its possible clinical correlates may provide clues to its etiology and pathogenesis. PMID:8742654

  2. Effect of Volatile Oil of Amomum on Expressions of Platelet Activating Factor and Mastocarcinoma-related Peptide in the Gastric Membrane of Chronic Gastritis Patients with Helicobacter-pylori Infection

    Institute of Scientific and Technical Information of China (English)

    HUANG Guo-dong; HUANG Yuan-hua; XIAO Mei-zhen; HUANG Dao-fu; LIU Juan; LI Jia-bang

    2008-01-01

    Objective: To observe the effect of volatile oil of amomum (VOA) on the expressions of mastocarcinoma-related peptide (PS2) and platelet activating factor (PAF) in helicobacter pylori-associated gastritis (HPG) and to analyze its potential mechanism. Methods: Eighty patients with HPG were randomly assigned to two groups, 42 patients in the treated group treated with 0.5 mL VOA, thrice per day; and the 38 patients in the control group receiving Western tertiary medicinal treatment. Gastroscopic picture and helicobacter pylori (HP) infection (by quick urease and Warthin-Starry stain) of the gastro-membrane, expressions of PS2 and PAF (by immunohistochemical assay and Western blotting) as well as the contents of aminohexose and phospholipid (by Neuhaus method) in the gastric membrane of all patients were detected before treatment and 4 weeks after treatment. The clinical efficacy in the two groups was compared. Results: The total effective rate in the treated group was 88.1%, which was significantly higher than that in the control group (78.9%, P 0.05). Conclusion: The mechanism of VOA for anti-gastritis might be related with its action in increasing the expression of PS2 and decreasing the expression of PAF, and thus regulating the hydrophobicity of the gastric membrane.

  3. Gastritis cystica profunda : a case report

    Energy Technology Data Exchange (ETDEWEB)

    Shim, Joo Eun; Kim, Ho Chul; Bae, Sang Hoon; Cho, So Yeon [Hallym Univ. College of Medicine, Chunchon (Korea, Republic of)

    1997-05-01

    Gastritis cystica profunda is an uncommon benign mass that usually occurs on the gastric side of the site of a gastroenterostomy, but has also been known to develop in which has not been operated on. We report the case of stomach a 51-years-old man with pathologically proven gastritis cystica profunda. This patient had not undergone gastric surgery CT showed a well-defined, 3cm sized, cystic mass at the gastric antrum.

  4. Immunoglobulin gene repertoire diversification and selection in the stomach – from gastritis to gastric lymphomas

    Directory of Open Access Journals (Sweden)

    Miri eMichaeli

    2014-06-01

    Full Text Available Chronic gastritis is characterized by gastric mucosal inflammation due to autoimmune responses or infection, frequently with Helicobacter pylori. Gastritis with H. pylori background can cause gastric mucosa-associated lymphoid tissue lymphoma (MALT-L, which sometimes further transforms into diffuse large B cell lymphoma (DLBCL. However, gastric DLBCL can also be initiated de novo. The mechanisms underlying transformation into DLBCL are not completely understood. We analyzed immunoglobulin repertoires and clonal trees to investigate whether and how immunoglobulin gene repertoires, clonal diversification and selection in gastritis, gastric MALT-L and DLBCL differ from each other and from normal responses. The two gastritis types (positive or negative for H. pylori had similarly diverse repertoires. MALT-L dominant clones presented higher diversification and longer mutational histories compared with all other conditions. DLBCL dominant clones displayed lower clonal diversification, suggesting the transforming events are triggered by similar responses in different patients. These results are surprising, as we expected to find similarities between the dominant clones of gastritis and MALT-L and between those of MALT-L and DLBCL.

  5. Gastric Lipase Secretion in Children with Gastritis

    Directory of Open Access Journals (Sweden)

    Krystyna Sztefko

    2013-07-01

    Full Text Available Gastric lipase is one of the prepancreatic lipases found in some mammalian species and in humans. Our knowledge of the hormonal regulation of gastric lipase secretion in children and adolescents is still very limited. The aim of this study was to compare the activity of human gastric lipase (HGL in gastric juice in healthy adolescents and in patients with gastritis. The adolescents were allocated to three groups: the first including patients with Helicobacter pylori gastritis (HPG; n = 10, the second including patients with superficial gastritis caused by pathogens other than H. pylori (non-HPG; n = 14 and the control group including healthy adolescents (n = 14. Activity of HGL was measured in gastric juice collected during endoscopy. Plasma concentrations of cholecystokinin (CCK, glucagon-like peptide-1 (GLP-1 and glucose-dependent insulinotropic peptide (GIP were measured in all adolescents. Activity of HGL in the non-HPG group was significantly lower than in the HPG group (p < 0.005 and the control group (p < 0.005. Mean plasma GIP levels in the control group were lower than in the non-HPG group (p < 0.003 and the HPG group (p < 0.01. We conclude that the regulation of HGL secretion by GLP-1 and CCK is altered in patients with gastritis. Moreover, GIP is a potent controller of HGL activity, both in healthy subjects and in patients with gastritis.

  6. [Severe hemorrhagic gastritis of radiation origin].

    Science.gov (United States)

    Flobert, C; Cellier, C; Landi, B; Berger, A; Durdux, C; Palazzo, L; Carnot, F; Cugnenc, P H; Barbier, J P

    1998-02-01

    Severe gastric complications due to radiotherapy are uncommon, in particular hemorrhagic gastritis. A high total dose and, above all, high daily fraction appear to be the main risk factors in gastric injuries. A case of hemorrhagic gastritis induced by radiotherapy requesting a total gastrectomy is reported. The patient was treated for a primary gastric non-Hodgkin's lymphoma. Hemorrhagic gastritis occurred despite a low total dose (40 Gy) and 2 Gy daily fractions. Upper gastrointestinal endoscopy and repeated biopsies are usually insufficient to exclude a tumor recurrence. Endoscopic ultrasonography may argue for a recurrence or for radiation lesions. As the conservative treatment is usually ineffective, these gastrointestinal radiation injuries ought to be treated surgically. Besides it allows to ascertain the benign nature of radiation lesions. PMID:9762196

  7. Collagenous gastritis: histopathologic features and association with other gastrointestinal diseases.

    Science.gov (United States)

    Leung, Stanley T; Chandan, Vishal S; Murray, Joseph A; Wu, Tsung-Teh

    2009-05-01

    Collagenous gastritis (CG) characterized by the deposition of a subepithelial collagen band and accompanying inflammatory infiltrate is a rare disorder. The natural history and pathogenesis of CG remain unclear. We describe the histologic features (23 gastric, 18 duodenal, and 4 colonic biopsies) and clinical findings of an additional 12 cases. Histologic features including active or chronic inflammation, surface epithelial injury, intraepithelial lymphocytosis, intestinal metaplasia, and Helicobacter pylori, and measurement of thickness of subepithelial collagenous band were evaluated in gastric biopsies. The clinical features, endoscopic findings, and follow-up were obtained and correlated with histologic features. There was an even number of males (n=6) and females (n=6). Four patients were children/young adults, 3 of whom (75%) presented with anemia and gastric nodularity. Eight patients were adults, 6 of whom (75%) had an associated autoimmune disease (1 with Hashimoto thyroiditis and polymyositis) or other intestinal disease (3 with celiac sprue, 1 with collagenous colitis, 1 with collagenous sprue), in contrast to none in the 4 children/young adults, P=0.06. The range of subepithelial collagen thickness was 15 to 120 microm in CG. The collagenous layer showed surface epithelial injury and entrapped inflammatory cells. On presentation, the thickened collagen distribution in the antrum and body was variably patchy and diffuse. Four (33%) patients showed lymphocytic gastritis (3 within the same biopsy); one of these patients also had celiac sprue and another had collagenous sprue. Three (25%) patients had celiac sprue (2 had duodenal biopsy proven and 1 had a clinical diagnosis of celiac sprue). An additional patient had duodenal biopsies showing collagenous sprue. Four patients had follow-up biopsies during a 3 to 119-month period after the diagnosis of CG. CG persisted on the follow-up gastric biopsies in 3 (75%) of the 4 patients, and the other patient had

  8. Dongwei Granule in treatment of chronic gastritis with cold obstruction causing qi stagnation and cold obstruction causing blood stasis:a randomized parallel controlled clinical trial%冬胃颗粒治疗寒凝气滞与寒凝血瘀型慢性胃炎疗效观察

    Institute of Scientific and Technical Information of China (English)

    于丽; 李昊燃; 雷春红; 陈晶; 林一帆; 赵明宏; 陆宇平; 高文艳; 巩阳; 刘杨; 季芳

    2012-01-01

    [Objective]To evaluate the clinical efficacy and safety of Dongwei Granule on chronic gastritis with cold obstruction causing qi stagnation (COCQS) and cold obstruction causing blood stasis(COCBS). [Methods]Eighty-six patients of chronic gastritis with COCQS and COCBS were selected for a randomized parallel controlled trial. The 43 cases in the study group were treated with Dongwei Granule 8g tid for seven days, while another 43 in the control group were given hydrotalcite 0. 5g tid, and then the clinical efficacy and safety were investigated. [Results]Both groups have some curative effect, however, the evaluation of curative effect of Dongwei Granule in abdominal pain,belching,anorexia at day 1,3,7,14 gained an advantage over that of hydrotalcite (P<0. 01). Although the effect of hydrotalcite in water brash was slightly superior to that of Dongwei Granule at day 1 and 3, there was no statistical significance(P=0. 5359,0. 7318),and the latter had better effect than the former at day 7 and day 14(P<0. 01). The evaluation of curative effect of Dongwei Granule in water brash gained an advantage over that of hydrotalcite(P<0. 01) by the analytical method of logistic model duplicate measurement,no obvious side effects were found. [Conclusion]Dongwei Granule could effectively prevent and cure chronic gastritis with COCQS and COCBS and quickly relieve the symptoms.%[目的]观察冬胃颗粒治疗寒凝气滞与寒凝血瘀型慢性胃炎的临床疗效及安全性.[方法]86例寒凝气滞与寒凝血瘀型慢性胃炎患者随机分为2组,试验组(43例)给予冬胃颗粒8 g,3次/d,对照组(43例)给予铝碳酸镁片0.5g,3次/d,2药均于两餐间及睡前服用,疗程为2周,观察各组第1、3、7、14天腹痛腹胀、泛酸、嗳气与纳差症状缓解情况,同时观察其安全性.[结果]2组患者均有一定疗效,但冬胃颗粒治疗后第1、3、7、14天患者腹痛腹胀、嗳气、纳差症状疗效指标的评价均优于铝碳酸镁(P<0.01),

  9. Effect observation of hydrotalcite combined with amoxicillin clavulanic acid and berberine in the treatment of chronic stubborn gastritis and gastric ulcer in 60 cases%铝碳酸镁联用阿莫西林克拉维酸钾及黄连素治疗慢性顽固性胃炎、胃溃疡60例效果观察

    Institute of Scientific and Technical Information of China (English)

    邱桂扣

    2015-01-01

    Objective:To explore the effect of hydrotalcite combined with amoxicillin clavulanic acid and berberine in the treatment of chronic stubborn gastritis,gastric ulcer.Methods:60 patients with chronic stubborn gastritis,gastric ulcer were selected. They were randomly divided into the study group and the control group with 30 cases in each.The control group were given hydrotalcite combined with amoxicillin clavulanic acid treatment.The study group were given hydrotalcite combined with amoxicillin clavulanic acid and berberine treatment.We compared the treatment efficiency,helicobacter pylori clearance rate, recurrence rate and the rate of adverse reactions of the two groups.Results:In the study group,the effective rate was 86.67% ;helicobacter pylori eradication rate was 73.33%;the recurrence rate was 10.00%.They were all significantly better than the control group(P0.05).Conclusion:Hydrotalcite combined with amoxicillin clavulanic acid and berberine in the treatment of chronic stubborn gastritis,gastric ulcer can significantly improve the clinical efficacy,and reduce the recurrence rate.%目的:探讨铝碳酸镁联用阿莫西林克拉维酸钾及黄连素治疗慢性顽固性胃炎、胃溃疡的疗效。方法:收治慢性顽固性胃炎、胃溃疡患者60例,随机平均分成研究组和对照组,对照组给予铝碳酸镁联合阿莫西林克拉维酸钾治疗,研究组应用铝碳酸镁联用阿莫西林克拉维酸钾及黄连素治疗,比较两组患者治疗有效率、幽门螺杆菌清除率、复发率及不良反应率。结果:研究组治疗有效率86.67%,幽门螺杆菌清除率73.33%,复发率10.00%,均显著优于对照组(P<0.05),不良反应率组间比较,差异无统计学意义(P>0.05)。结论:铝碳酸镁联用阿莫西林克拉维酸钾及黄连素治疗慢性顽固性胃炎、胃溃疡能显著提高临床疗效、降低复发率。

  10. 综合护理干预对慢性胃炎及消化性溃疡患者生活质量的影响分析%Effect of comprehensive nursing intervention on quality of life of patients with chronic gastritis and peptic ulcer

    Institute of Scientific and Technical Information of China (English)

    陈敏

    2016-01-01

    目的:针对慢性胃炎及消化性溃疡患者,讨论临床实施综合护理干预,观察对患者生活质量的影响,为日后的临床护理提供参考及指导。方法选择我院于2013年3月—2015年5月收治的慢性胃炎及消化性溃疡患者160例为研究对象,临床应用抽签的方法,将160例患者随机划分为两组,分别定义为观察组及对照组,每组患者80例。对照组患者给予常规护理,观察组患者给予综合护理干预,对比两组患者的临床护理效果。结果经过临床护理干预,两组患者在护理满意度方面,观察组患者为98.75%,对照组患者为81.25%,临床比较差异显著,P﹤0.05,观察组优于对照组。在NHP评分方面,两组患者比较差异显著,临床有统计学意义,P﹤0.05,观察组优于对照组。结论针对慢性胃炎及消化性溃疡患者,临床实施综合护理干预后,患者临床表现缓解明显,身体素质提升,生活质量较高,对患者积极作用较大。建议在今后的临床护理中,将综合护理推广应用。%Objective:to discuss the clinical effect of comprehensive nursing intervention on patients with chronic gas-tritis and peptic ulcer,to provide reference and guidance for clinical nursing in the future. Methods:in our hospital in March 2013 —2015 years 5 months from chronic gastritis and digestive ulcer patients 160 cases as the object of study, clinical application of the draw method,160 cases were randomly divided into two groups were defined as the observation group and the control group. Each group of 80 cases of patients. Patients in the control group were given routine nursing, the observation group were given comprehensive nursing intervention,the clinical nursing effect of the two groups were com-pared. Results:after clinical nursing intervention,the two groups of patients in nursing satisfaction,the observation group was 98. 75%,the control group was 81. 25%,the

  11. How host regulation of Helicobacter pylori-induced gastritis protects against peptic ulcer disease and gastric cancer.

    Science.gov (United States)

    Dhar, Poshmaal; Ng, Garrett Z; Sutton, Philip

    2016-09-01

    The bacterial pathogen Helicobacter pylori is the etiological agent of a range of gastrointestinal pathologies including peptic ulcer disease and the major killer, gastric adenocarcinoma. Infection with this bacterium induces a chronic inflammatory response in the gastric mucosa (gastritis). It is this gastritis that, over decades, eventually drives the development of H. pylori-associated disease in some individuals. The majority of studies investigating H. pylori pathogenesis have focused on factors that promote disease development in infected individuals. However, an estimated 85% of those infected with H. pylori remain completely asymptomatic, despite the presence of pathogenic bacteria that drive a chronic gastritis that lasts many decades. This indicates the presence of highly effective regulatory processes in the host that, in most cases, keeps a check on inflammation and protect against disease. In this minireview we discuss such known host factors and how they prevent the development of H. pylori-associated pathologies.

  12. The Effect of Pimecrolimus Cream 1% Compared with Triamcinolone Acetonide Paste in Treatment of Atrophic-Erosive Oral Lichen Planus

    OpenAIRE

    Atessa Pakfetrat; Zahra Delavarian; Farnaz Falaki; Mahboubeh Khorashadizadeh; Mina Saba

    2015-01-01

    Introduction: Oral lichen planus (OLP) is a common chronic mucocutaneous disease. Patients with atrophic and erosive types of OLP often have symptoms of soreness, and require proper treatment. The main treatment for OLP has been the administration of topical or systemic corticosteroids. The objective of this study was to compare the efficacy of adcortyl cream (triamcinolone acetonide in orabase) with topical pimecrolimus cream for the treatment of erosive OLP.   Materials and Methods: Twenty-...

  13. Research on medication regularity of pattern of internal accumulation of zhuodu in chronic atrophic gastritis based on correspondence between prescription and syndrome%基于方证相应的慢性萎缩性胃炎浊毒内蕴证用药规律研究

    Institute of Scientific and Technical Information of China (English)

    周盼盼; 王彦刚; 吕静静

    2014-01-01

    收集200例慢性萎缩性胃炎(CAG)患者的病历,详细记录其性别、年龄、电子胃镜及病理结果、临床症状、中药处方,并进行统计分析,以“黄金分割法”为判别依据,采用频数统计和关联规则分析进行药物与证候之间关联规则的挖掘.研究化浊解毒方药治疗CAG的用药规律,探寻化浊解毒方与浊毒内蕴证稳定的方证关系.经数据处理,共得到中药153味,根据“黄金分割法”的原则,使用频率在61.8%以上(含61.8%)的药物共有15种,作为CAG浊毒内蕴证治疗的核心药物.出现频次最多的临床症状共10种,作为CAG浊毒内蕴证的主要症状表现.通过关联规则分析发现药物和脉证之间具有较强相关性,说明CAG浊毒内蕴证与化浊解毒方方证的高度相应,体现了CAG的关键病机为浊毒内蕴,“化浊解毒法”为与之相对应的治疗大法.

  14. 慢性萎缩性胃炎胃黏膜病理改变与CagA VacA的关系%The research on the relationship between the pathological changes of gastric mucosa in chronic atrophic gastritis and the virulence factors CagA, VacA in Helicobacter pylori

    Institute of Scientific and Technical Information of China (English)

    孟祥军; 吴建新; 李定国; 陆汉明

    2003-01-01

    目的研究慢性萎缩性胃炎时胃黏膜不同的病理变化与幽门螺杆菌(Helicobaterpylori,Hp)致病因子CagA VacA之间的关系.方法120例Hp阳性的慢性萎缩性胃炎患者按黏膜炎症和黏膜萎缩的程度及肠化的有无进行分组,并抽取血清,通过Westernblot法测定血清中特异性抗体CagA(116KD)和VacA(89KD).结果①慢性萎缩性胃炎黏膜炎症的程度与CagA检出的阳性率显著相关,炎症程度严重的病例CagA抗体阳性率显著高于轻度炎症病例(85.1%vs 53.28%,P<0.005);②胃黏膜重度萎缩者VacA抗体阳性率显著高于胃黏膜轻度萎缩者(77.8%vs 38.7%,P<0.005);③慢性萎缩性胃炎患者VacA抗体阳性者多有肠化生,其肠化生的发生率显著高于VacA抗体阴性患者(84.1%vs 30.3%,P<0.005).结论CagA的表达同慢性萎缩性胃炎的严重程度密切相关,其表达的阳性率愈高胃黏膜炎症程度愈重,而VacA的表达则同胃黏膜的萎缩及肠化密切相关,胃黏膜重度萎缩与肠化患者VacA的表达率显著高于胃黏膜轻度萎缩与肠化的患者.

  15. Effect of Shenzhi Xiaowei Decoction on Outcomes of Precancerous Lesions of Gastric Cancer in Patients with Chronic Atrophic Gastritis (Qi-stagnation Syndrome of Liver and Stomach)%参枳消萎汤对慢性萎缩性胃炎癌前病(肝胃气滞证)变转归的影响

    Institute of Scientific and Technical Information of China (English)

    张玉峰; 刘新爱; 叶坤英; 高希言

    2016-01-01

    目的:探讨参枳消萎汤对慢性萎缩性胃炎(CAG)胃炎癌前病(PLGC)(肝胃气滞证)转归和血清三叶因子3(TFF3)及胃泌素-17的影响.方法:89例PLGC随机按数字表法以1∶1原则分为对照组44和观察组45例.对照组口服胃苏颗粒,15 g/次,3次/d.观察组采用参枳消萎汤内服,1剂/d.两组疗程均为16周.进行治疗前后胃黏膜组织病理学检查;进行治疗前后胃脘疼痛、饱胀、痞闷、暖气、纳差评分;检测治疗前后TFF3和胃泌素-17水平.结果:观察组治疗后胃镜、胃黏膜临床病理疗效总有效率为100%,高于对照组的84.1% (P <0.05);治疗后观察组萎缩程度,肠上皮化生(IM)和异型增生(Dys)病理评分均低于对照组(JP<0.01);观察组胃脘疼痛、饱胀、痞闷、暖气、纳差等主要症状评分均低于对照组(P<0.01);治疗后两组血清TFF3水平均显著下降,观察组下降更为明显(P<0.01);两组血清胃泌素-17水平明显升高,观察组升高更为显著(P<0.01).结论:参枳消萎汤能阻断或逆转胃癌前病变(PLGC),延缓CAG向胃癌的发展,临床疗效显著.

  16. The Analysis on the Clinical and Pathological Characteristics of Major Premalignant Gastritis%主要癌前胃炎症性疾病的临床及病理特点分析

    Institute of Scientific and Technical Information of China (English)

    张林; 侯艳红; 吴凯; 瞿俊山; 朱超慧

    2011-01-01

    Objective To investigate the clinical and pathological characteristics of major premalignant gastritis for optimizing the therapeutic and preventative measures for these diseases.Methods The cases with varioliform gastritis and atrophic gastritis were selected and analyzed from all of the old military personnels who received the gastrosopic examinations in recent five years in our hospital.The clinical symptoms, the pathological characteristics and the rate of helicaobacter pylori (Hp) infection were compared between the cases with varioliform gastritis and atrophic gastritis.Results The prevalence rates of varioliform gastritis and atrophic gastritis were 8.9% and 10.1% respectively.The incidence rates occurring of abdominal pain,nausea, hearburn and hemafecia in the cases of varioliform gastritis were higher than those with atrophic gastritis cases ( P <0.05 ).The rates of abdominal distention and anorexia were higher in atrophic gastritis cases ( P < 0.05 ).The rates of intestinal metaplastia and atypical hyperplasia in the pathological examination in the cases of two types gastritis were sinificant different ( P < 0.05 ).Conclusion As premalignant gastritis, the cases with varioliform gastritis and atrophic gastritis could have some particular clinical symptoms.The epigastric symptoms could be more severe and the rate of atypical hyperplasia could be higher in the patients with varioliform gastritis.So varioliform gastritis could be more detrimental and should be paid more attention.%目的 探讨部队特定中老年保健人群主要胃癌前炎症性疾病的发生情况及临床与病理特点,优化此类疾病的预防与诊疗措施.方法 通过研究分析近5年来我院接受电子胃镜检查的中老年人的临床及病理资料,对比主要的癌前胃炎症性疾病:萎缩性胃炎和疣状胃炎的临床表现、病理表现、幽门螺杆菌(Hp)感染率等,分析两类不同胃炎的特性.结果 本组患者

  17. Dailixin coalition esso beauty pull azole, Mosapride in curative effects in the treatment of chronic gastritis%黛力新联合埃索美拉唑、莫沙必利在慢性胃炎治疗中的疗效观察

    Institute of Scientific and Technical Information of China (English)

    吴晨芳

    2015-01-01

    Objective:Watch Dailixin coalition esso beauty pull azole, Mosapride in efficacy in the treatment of chronic gastritis. Methods:Choose 60 cases of patients with chronic gastritis, were randomly divided into observation group and control group. Observation group patients give Dailixin coalition esso beauty pull azole magnesium enteric-coated metformin hydrochloride, Mosapride benefit citrate capsules;Control group patients give the esso beauty only pull azole magnesium enteric-coated metformin hydrochloride and citrate moser will benefit. Results:Compared with the control group, experimental group patients after treatment of GSRS-C score down more obvious compared with before treatment (P<0.05). Compared with the control group, experimental group patients after treatment HAD score down more obvious compared with before treatment (P<0.05). Conclusions:Dailixin coalition esso beauty pull azole, Mosapride has obvious curative effect in the treatment of chronic gastritis.%目的:观察黛力新联合埃索美拉唑、莫沙必利在慢性胃炎治疗(chronic gastritis, CG)中的疗效。方法:选择某医院消化内科门诊及入院治疗的符合入组标准的60例慢性胃炎(CG)患者,随机分为观察组和对照组两组。观察组患者给予黛力新联合埃索美拉唑镁肠溶片、枸橼酸莫沙必利胶囊;对照组患者仅仅给予埃索美拉唑镁肠溶片以及枸橼酸莫沙必利片,剂量和服药时间均和观察组的一样。疗程均为4周,试验开始前和4周后,两组患者分别行GSRS-C、HAD、EQ-5D评估并记录评分。所有患者在整个试验过程中如出现不良反应会被详细的予以记录。结果:1.通过两组治疗前后GSRS-C评分的记录,治疗后试验组与对照组患者的GSRS-C评分与治疗前相比,均有明显下降(P<0.05);与对照组相比,试验组患者治疗后的GSRS-C评分较治疗前下降更明显(P<0.05)。两组治疗后症状疗效相比,试验组为93.75%,对照组为78

  18. Atrophic gastric changes in both Helicobacter felis and Helicobacter pylori infected mice are host dependent and separate from antral gastritis.

    OpenAIRE

    Sakagami, T; Dixon, M; O'Rourke, J; Howlett, R.; Alderuccio, F; Vella, J; Shimoyama, T; Lee, A.

    1996-01-01

    BACKGROUND/AIMS: The role of host factors has been neglected in studies of the pathogenesis of Helicobacter associated disease. The aim of this study was to assess the response of different mouse strains to infection with a single strain of Helicobacter felis. METHOD: Six strains of inbred mice were infected with the identical H felis culture and were killed at one month, two months, and six months after infection to assess histopathological changes. In addition, two strains of mice were infe...

  19. Helicobacter pylori y estrés psicosocial en pacientes con gastritis crónica.

    Directory of Open Access Journals (Sweden)

    José I. Montaño

    2009-11-01

    Full Text Available Objective: The aim of the study was to describe the prevalence of Helicobacter pylori and psychosocial stress in patients with chronic gastritis. Methods: A pilot case-control study was performed in patients with chronic gastritis. The study group included patients infected with H. pylori and the control group included patients without infection. The patients were recruited at the Valle University Hospital (VUH and the Valle del Lili Foundation (VLF in Cali, Colombia during 2003. The H. pylori infection was determined by gastric endoscopy and the psychosocial stress by the Hospital Anxiety Depression Scale (HADS. Results: 164 patients were included, 74 (45.1% in VUH and 90 (54.9% in VLF. The socio-demographic characteristics were comparable in both institutions and both groups. H. pylori infection was observed in 113 (68.9% patients and psychosocial stress in 115 (70.1%. Anxiety levels were higher than depression levels; (anxiety median=9, range 1-20; depression median=6, range 0-17 especially in VUH (p=0.03 associated to low socioeconomic status (p Conclusion: Patients with chronic gastritis had a high prevalence of H. pylori infection and psychosocial stress without association between the two variables.

  20. Malignant atrophic papulosis (Köhlmeier-Degos disease - A review

    Directory of Open Access Journals (Sweden)

    Theodoridis Athanasios

    2013-01-01

    Full Text Available Abstract Definition of the disease Malignant atrophic papulosis (MAP, described independently by Köhlmeier and Degos et al., is a rare, chronic, thrombo-obliterative vasculopathy characterized by papular skin lesions with central porcelain-white atrophy and surrounding teleangiectatic rim. Epidemiology Less than 200 cases have been described in the literature. The first manifestation of MAP usually occurs between the 20th and 50th year of life. Clinical description The cutaneous clinical picture is almost pathognomonic. The histology is not consistent but in most cases it shows a wedge-shaped connective tissue necrosis in the deep corium due to a thrombotic occlusion of the small arteries. In the systemic variant, manifestations mostly occur at the intestine and central nervous system. Etiology The etiopathogenesis of the disease remains unknown, a genetic predisposition may occur. Vasculitis, coagulopathy or primary dysfunction of the endothelial cells have been implicated. Diagnostic methods Diagnosis is only based on the characteristic skin lesions. Differrential diagnosis It depends on the clinical presentation of MAP, but systemic lupus erythematosus and other connective tissue diseases need to be considered. Management No effective treatment exists for the systemic manifestations, while compounds that facilitate blood perfusion have achieved a partial regression of the skin lesions in single cases. Prognosis An apparently idiopathic, monosymptomatic, cutaneous, benign variant and a progressive, visceral one with approx. 50% lethality within 2–3 years have been reported. Systemic manifestations can develop years after the occurrence of skin lesions leading to bowel perforation and peritonitis, thrombosis of the cerebral arteries or massive intracerebral hemorrhage, meningitis, encephalitis, radiculopathy, myelitis.

  1. Progressive atrophic rhinitis in a medium-scale pig farm in Kiambu, Kenya : case report

    Directory of Open Access Journals (Sweden)

    J.K. Wabacha

    2000-07-01

    Full Text Available Forty-two pigs in a herd of 117 displayed various clinical signs of progressive atrophic rhinitis. The main signs included sneezing, coughing, lachrymation, serous to muco-purulent nasal discharge, and nasal bleeding in 1 pig. Three pigs had lateral deviation of the snout, while 4 had brachygnathia superior with obvious deformation of the face. Four acutely affected weaner pigs appeared weak, while the 7 chronically-affected pigs appeared smaller than their apparently unaffected penmates of the same age. Treatment of the acutely affected pigs with long-acting oxytetracycline at 20 mg/kg body weight intra-muscularly, repeated once after 7 days, reduced the severity but did not clear the sneezing from all the pigs. Fifteen pigs were slaughtered 2 months after the clinical diagnosis was made. The carcasses of the chronically affected pigs were about 15 % lighter than those of the apparently normal pigs of the same age and from the same pen, which translated to a loss of 921.00 Kenya shillings per pig (US$13.7. Diagnosis of progressive atrophic rhinitis was confirmed by sectioning the snouts of randomly selected slaughtered pigs with obvious deformation of the snout. Sections were madeat the level of the 1st/2nd upper premolar tooth. Varying degrees of turbinate atrophy, from mild to complete, were noted. Histopathology of the turbinates revealed metaplasia of nasal epithelium and fibrosis in the lamina propria.

  2. Atrophic Vaginitis in Breast Cancer Survivors: A Difficult Survivorship Issue

    Directory of Open Access Journals (Sweden)

    Joanne Lester

    2015-03-01

    Full Text Available Management of breast cancer includes systematic therapies including chemotherapy and endocrine therapy can lead to a variety of symptoms that can impair the quality of life of many breast cancer survivors. Atrophic vaginitis, caused by decreased levels of circulating estrogen to urinary and vaginal receptors, is commonly experienced by this group. Chemotherapy induced ovarian failure and endocrine therapies including aromatase inhibitors and selective estrogen receptor modulators can trigger the onset of atrophic vaginitis or exacerbate existing symptoms. Symptoms of atrophic vaginitis include vaginal dryness, dyspareunia, and irritation of genital skin, pruritus, burning, vaginal discharge, and soreness. The diagnosis of atrophic vaginitis is confirmed through patient-reported symptoms and gynecological examination of external structures, introitus, and vaginal mucosa. Lifestyle modifications can be helpful but are usually insufficient to significantly improve symptoms. Non-hormonal vaginal therapies may provide additional relief by increasing vaginal moisture and fluid. Systemic estrogen therapy is contraindicated in breast cancer survivors. Continued investigations of various treatments for atrophic vaginitis are necessary. Local estrogen-based therapies, DHEA, testosterone, and pH-balanced gels continue to be evaluated in ongoing studies. Definitive results are needed pertaining to the safety of topical estrogens in breast cancer survivors.

  3. Myeloid HIF-1 is protective in Helicobacter pylori-mediated gastritis.

    Science.gov (United States)

    Matak, Pavle; Heinis, Mylène; Mathieu, Jacques R R; Corriden, Ross; Cuvellier, Sylvain; Delga, Stéphanie; Mounier, Rémi; Rouquette, Alexandre; Raymond, Josette; Lamarque, Dominique; Emile, Jean-François; Nizet, Victor; Touati, Eliette; Peyssonnaux, Carole

    2015-04-01

    Helicobacter pylori infection triggers chronic inflammation of the gastric mucosa that may progress to gastric cancer. The hypoxia-inducible factors (HIFs) are the central mediators of cellular adaptation to low oxygen levels (hypoxia), but they have emerged recently as major transcriptional regulators of immunity and inflammation. No studies have investigated whether H. pylori affects HIF signaling in immune cells and a potential role for HIF in H. pylori-mediated gastritis. HIF-1 and HIF-2 expression was examined in human H. pylori-positive gastritis biopsies. Subsequent experiments were performed in naive and polarized bone marrow-derived macrophages from wild-type (WT) and myeloid HIF-1α-null mice (HIF-1(Δmyel)). WT and HIF-1(Δmyel) mice were inoculated with H. pylori by oral gavage and sacrificed 6 mo postinfection. HIF-1 was specifically expressed in macrophages of human H. pylori-positive gastritis biopsies. Macrophage HIF-1 strongly contributed to the induction of proinflammatory genes (IL-6, IL-1β) and inducible NO synthase in response to H. pylori. HIF-2 expression and markers of M2 macrophage differentiation were decreased in response to H. pylori. HIF-1(Δmyel) mice inoculated with H. pylori for 6 mo presented with a similar bacterial colonization than WT mice but, surprisingly, a global increase of inflammation, leading to a worsening of the gastritis, measured by an increased epithelial cell proliferation. In conclusion, myeloid HIF-1 is protective in H. pylori-mediated gastritis, pointing to the complex counterbalancing roles of innate immune and inflammatory phenotypes in driving this pathology. PMID:25710915

  4. HELICOBACTER PYLORI-RELATED GASTRITIS AND LYMPHOID TISSUE HYPERPLASIA IN THE AGED

    Institute of Scientific and Technical Information of China (English)

    高天; 陈晓宇; 胡梅洁

    2003-01-01

    Objective To examine the relationship between Helicobacter pylori-related gastritis and the development of lymphoid tissue hyperplasia in the antral mucosa and to pursue its evolution after eradication of H.pylori in the aged. Methods Gastric antral mucosa biopsy specimens for microscopic study were obtained from 101 chronic gastritis patients over 60 years old with H.pylori-positive in the period from 2000 to 2001, and meanwhile those from 124 H.pylori-positive chronic gastritis patients under the age of 60 served as controls. Four to six weeks after a course of anti-H.pylori therapy, biopsy specimens were again obtained. Lym-phoid follicles and aggregates were counted and other pathologic features were scored according to the updated Sydney System for classification of chronic gastritis. Results The prevalence and density of lymphoid follicles and aggregates were significantly lower in the aged as compared with those in the control group, being 36. 6%(37/101) and 0. 41 vs. 72. 5%(90/124) and 0. 81, respectively(P<0.0001). The prevalence and density of lymphoid follicles and aggregates correlated strongly with the activity and severity of gastric antral mucosal inflammation in both groups. Eradication of H.pylori resulted in a decrease in the prevalence and density of lymphoid follicles and aggregates in both groups, especially in the aged group. Conclusion The prevalence and density of lymphoid follicles and aggregates in gastric antral mucosal biopsies correlated closely with H.phlori infection in the aged, therefore, anti-H.pylori treatment would be of importance to the aged patients infected with H.pylori.

  5. Collagenous colitis and collagenous gastritis in a 9 year old girl: a case report and review of the literature.

    Science.gov (United States)

    Camarero Salces, C; Enes Romero, P; Redondo, C; Rizo Pascual, J M; Roy Ariño, G

    2011-09-01

    Collagenous gastritis is a rare disease in the general population and collagenous colitis has seldom been reported in children. We report a girl with both diseases and review the literature on this association afetr a systematic search of Pubmed, Medline and Embase databases.. The girl, diagnosed of collagenous colitis at the age of 2 years, started with abdominal pain and anaemia at the age of 9 years and was diagnosed of collagenous gastritis in the gastric biopsies. After review of the literature, we found 66 reported cases (33 children, 33 adults, 68% females), 56 patients with collagenous gastritis and 16 children with collagenous colitis. Both disorders coexisted in 20 patients. The main presenting symptoms are abdominal pain and anaemia in patients with collagenous gastritis and diarrhoea and weight loss in patients with both disorders. Hypoalbuminemia was found in 9 patients with both diseases and protein losing enteropathy was demonstrated in 3 cases. Deposits of collagen in the duodenum were observed in 13 of 19 patients with both diseases. Seventeen of 66 patients had associated autoimmune disorders, particularly in patients with both diseases (35%). These conditions have a chronic course but gastric or colonic malignancies have not been communicated to date. In conclusion, collagenous gastritis and collagenous colitis mainly affects women and can occur at any age. Their association is exceptional. These disorders, although rare, should be considered in patients with anaemia and epigastric pain, watery diarrhoea or protein losing enteropathy. PMID:22103057

  6. Collagenous gastritis in the pediatric age

    OpenAIRE

    Antonio Rosell-Camps; Joana María Riera-Llodrá; Marina Colom-Segui; Sara Zibetti; Isabel Amengual-Antich

    2015-01-01

    Collagenous gastritis (CG) is an uncommon condition known in the pediatric age. It is characterized by the presence of subepithelial collagen bands (> 10 μm) associated with lymphoplasmacytic infiltration of the stomach's lamina propria. Symptoms manifested by patients with CG may be common with many other disorders. It typically manifests with epigastralgia, vomiting, and iron deficiency during pre-adolescence. This condition's pathophysiology remains unclear. In contrast to adults, where as...

  7. Collagenous gastritis: reports and systematic review.

    Science.gov (United States)

    Brain, Oliver; Rajaguru, Chandima; Warren, Bryan; Booth, Jonathan; Travis, Simon

    2009-12-01

    Collagenous gastritis is a rare disorder first described in 1989. After encountering two cases, we decided to review the literature and evaluate the collagen band. A systematic review of PubMed and EMBASE databases was performed. Twenty-eight cases have been previously described and two patterns of presentations are identifiable: children or young adults (median age 12 years, range 2-22 years) presenting with symptoms attributable to the gastritis (anaemia and pain); and older adults (median age 52 years, range 35-77 years) presenting with loose stools, often associated with collagenous colitis or coeliac disease. Our two cases (one child and one adult) matched this pattern. Immunostaining of the collagen band for collagens II, III, IV and VI, and tenascin showed that the band in our cases was predominantly tenascin. In conclusion, collagenous gastritis is a rare entity whose presentation depends on the age of the patient. An autoimmune aetiology seems possible given its associations. Treatment is empirical. The 30 cases now reported show that the disorder can relapse or persist for years. PMID:19730387

  8. Contrast of succinate dehydrogenase vitality and cytochrome C content in rats of different syn-dromes of chronic superficial gastritis%慢性浅表性胃炎不同证型大鼠琥珀酸脱氢酶活性与细胞色素C含量对比研究

    Institute of Scientific and Technical Information of China (English)

    王丽; 李翌萌

    2015-01-01

    目的:探讨慢性浅表性胃炎( chronic superficial gastritis, CSG)脾虚与湿热证模型大鼠胃组织琥珀酸脱氢酶( succinate dehydrogenase,SDH)的活性及细胞色素C( cytochrome C,Cyt-C)的含量变化,从能量代谢的角度揭示CSG不同证候的实质。方法用水杨酸钠溶液灌胃法复制大鼠单纯CSG模型,在此基础上,用小承气汤泻下法及饥饱失常法复制脾虚CSG模型;用肥甘辛辣饮食法复制湿热CSG模型,5周后,检测大鼠胃组织琥珀酸脱氢酶活性及细胞色素C含量。结果 SDH的含量为:湿热CSG组最高,而脾虚CSG组最低。脾虚CSG组与湿热CSG组分别与其他组比较,差异均有统计学意义(P<0.05或P<0.01);胞浆中Cyt-C含量造模组均高于正常组,差异有统计学意义(P<0.05或P<0.01),其中脾虚CSG组最高,湿热CSG组次之,两组之间比较,差异有统计学意义(P<0.01)。结论 CSG不同证型大鼠胃组织SDH活性及Cyt-C含量的差异,提示同一疾病不同证型之间能量代谢状态的不同,湿热证相对于脾虚证能量代谢较亢进。%Objective To explore the mechanisms of different syndromes in terms of the energy metabolism by observing the activity changes of succinate dehydrogenase ( SDH) and the content changes of cytochrome C ( Cyt-C) in rats with chronic superficial gastritis ( CSG) of spleen-deficiency syndrome and damp-heat syndrome. Methods CSG rat model was established by the intragastric administration of sodi-um salicylate solution. CSG rat model with spleen-deficiency syndrome was established by Xiaochengqi De-coction-induced purgation and eating disorders. CSG rat model with damp-heat syndrome was established by feeding fat, sweet and spicy diet. Five weeks later, SDH activity and Cyt-C content of gastric tissue were determined. Results The activity of SDH in damp-heat CSG group was the highest of all, but which in spleen-deficiency CSG group was the lowest . The activity of SDH was obviously changed

  9. Atrophic Acne Scarring: A Review of Treatment Options

    OpenAIRE

    Hession, Meghan T.; Graber, Emmy M.

    2015-01-01

    Background: Scarring is an unfortunate and frequent complication of acne, resulting in significant psychological distress for patients. Fortunately, numerous treatment options exist for acne scarring. Objectives: To extensively review the literature on treatment options for atrophic acne scarring. Materials and methods: A comprehensive literature search was conducted on the following topics: dermabrasion, subcision, punch techniques, chemical peels, tissue augmentation, and lasers. Results: T...

  10. 中西医结合治疗肝胃郁热型慢性胃炎临床研究%Clinical Study on Integrated Traditional Chinese and Western Medicine in the Treatment of Chronic Gastritis due to Accumulation of Heat in the Liver and Stomach

    Institute of Scientific and Technical Information of China (English)

    晋相林

    2011-01-01

    Objective: To observe the clinical effects of Sanshen Weiyan Decoction integrated with Western Medicine in treating chronic erosive gastritis due to accumulation of heat in the liver and stomach. Methods: 100 patients of chronic erosive gastritis in accordance with inclusive criteria were randomly divided into two groups, each of 50 cases, according to the orders of their treatment. Patients in control group were treated by Omeprazole Capsules, 20mg each time and twice a day before meals, and Amoxycillin Capsules were taken by 1.0g each time and twice a day; after meals, Clarithromycin Tablets 0. 5g were taken each time and twice a day. Seven days later, Omeprazole Capsules were taken 20mg each time and once a day, for another 14days. Patients in treatment group were treated by Sanshen Weiyan Decoction besides the drugs taken by the control group, one formula each day, after fried with water, and the decoction should be taken twice, once in the morning and once in the evening. Both groups took 21days as a course of treatment, during which patients were forbidden to have cool, cold, bitter and feast foods. Results: ① Total effect comparisons between the two groups showed that the mean rank of the control group was 43.54, while the treatment group was 57.46. The Mann-Whitney U statistics were 902. 00; Wilcoxon were 2177. 00; the Z test statistics Z=2. 594, p =0. 009 (double -sided), and the effects of the two groups had significant difference, which showed that the treatment group was better than the control group. ② The total effective rates of the two groups showed that the treatment group was 88.00% while the control group was 72. 00%. After being compared, x2 = 4. 000 v = 1 and p = O. 046, which showed that the difference between both groups was significant and the treatment group was better than the control group. ③ The total effective rates of the two groups on fighting high pressure (HP): the treatment group was 86. 00% while the control group was

  11. Research on Differentially Expressed Genes Related to Substance and Energy Metabolism between Healthy Volunteers and Splenasthenic Syndrome Patients with Chronic Superficial Gastritis%慢性浅表性胃炎脾虚证患者与健康人物质能量代谢基因差异表达研究

    Institute of Scientific and Technical Information of China (English)

    杨泽民; 陈蔚文; 王颖芳

    2013-01-01

    Objective To analyze the metabolic states of the lipids, protein, carbohydrate, and nucleic acid for chronic superficial gastritis patients of splenasthenic syndrome (SS), and to explore the pathogenesis mechanism of SS based on substance and energy metabolisms. Methods During June 2004 to March 2005, recruited were four chronic superficial gastritis patients of SS who visited at the First Hospital of Guangzhou University of Chinese Medicine and Guangdong Provincial Hospital of Traditional Chinese Medicine. Four healthy volunteers were recruited from Guangzhou University of Chinese Medicine. Their gastric mucosa was extracted to perform experiments of DNA microarray. The dual-channel DNA microarray data were mined and bioinformatically analyzed by BRB Array Tools and IPA software. Results Fifteen genes were involved in substance and energy metabolisms in 20 differentially expressed genes, accounting for 75%. Among these genes, one gene was up-regulated, 14 genes down-regulated, and 11 genes were enzyme gene. Differentially expressed genes related to lipid metabolism included ACAA2 and CYP20A1, manifested as fatty acid catabolism and cholesterol transformation. Genes related to protein metabolism included ALDH9A1, ASL, ASS1, PCY-OX1L, RPS28, UBE2D2, UBXN1, B3GNT1, GCNT1, and PPP1R3C, manifested as decreased amino acid metabolism that may affect the biologic processes such as autonomic nerve, urea cycle, etc., reduced protein synthesis, increased ubiquitination of fault fold proteins, and decreased post-translated modification of glyco-sylation and dephosphorylation. Genes related to carbohydrate metabolism included PPP1R3C, B3GNT1, and GCNT1, manifested as decreased glucogen and glycan syntheses. Genes related to nucleic acid metabolism included RMI1, SMARCD3, and PARP1, manifested as degraded DNA duplication and transcription, and increased DNA damage repair. Conclusions The metabolisms of the lipids, protein, carbohydrate, and nucleic acid in chronic superficial

  12. Gastritis, Enteritis, and Colitis in Horses.

    Science.gov (United States)

    Uzal, Francisco A; Diab, Santiago S

    2015-08-01

    The gastrointestinal system of horses is affected by a large variety of inflammatory infectious and noninfectious conditions. The most prevalent form of gastritis is associated with ulceration of the pars esophagea. Although the diagnostic techniques for alimentary diseases of horses have improved significantly over the past few years, difficulties still exist in establishing the causes of a significant number of enteric diseases in this species. This problem is compounded by several agents of enteric disease also being found in the intestine of clinically normal horses, which questions the validity of the mere detection of these agents in the intestine.

  13. Spontaneous Gastric Perforation in a Case of Collagenous Gastritis.

    Science.gov (United States)

    Appelman, Marly H; de Meij, Tim G J; Neefjes-Borst, E Andra; Kneepkens, C M F

    2016-01-01

    Collagenous gastritis is an extremely rare disease, both in children and adults. Symptoms vary depending on the extent of collagenous changes in the bowel. In most of the children, iron deficiency anemia and abdominal pain are the presenting symptoms. We present a 15-year-old boy with acute abdomen due to gastric perforation the cause of which was collagenous gastritis. PMID:26816680

  14. Spontaneous Gastric Perforation in a Case of Collagenous Gastritis

    Directory of Open Access Journals (Sweden)

    Marly Appelman

    2016-01-01

    Full Text Available Collagenous gastritis is an extremely rare disease, both in children and adults. Symptoms vary depending on the extent of collagenous changes in the bowel. In most of the children, iron deficiency anemia and abdominal pain are the presenting symptoms. We present a 15-year-old boy with acute abdomen due to gastric perforation the cause of which was collagenous gastritis.

  15. Spontaneous Gastric Perforation in a Case of Collagenous Gastritis

    OpenAIRE

    Marly Appelman; Tim G.J. de Meij; E. Andra Neefjes-Borst; C.M. Frank Kneepkens

    2016-01-01

    Collagenous gastritis is an extremely rare disease, both in children and adults. Symptoms vary depending on the extent of collagenous changes in the bowel. In most of the children, iron deficiency anemia and abdominal pain are the presenting symptoms. We present a 15-year-old boy with acute abdomen due to gastric perforation the cause of which was collagenous gastritis.

  16. A survey on Candida colonization prevalence in patients with gastritis, duodenitis and peptic ulcer

    Directory of Open Access Journals (Sweden)

    "S.J. Hashemi

    2006-07-01

    Full Text Available Background: Prolonged antiacid and antibiotic usage in gasterointestinal diseases may predispose candidial colonization in GI tract. In order to isolate and diagnose of candida infections in patients with gastritis, duodenitis, gastric ulcer and duodenal ulcer, this study have been planned. Methods: We studied 300 biopsy specimens of patients referred to hospital, 51.7% of the patients were male and the others were female. The isolated fungi were identified by direct examination and culture of specimens. Results: Forthy four cases of yeasts were isolated in this investigation. Isolated yeasts have been identified as follows: 26 cases of C.albicance , I case C.tropicalis, 2 cases of C.krusei, and finally 1 case of unknown yeast. Conclusion: All the patients had a positive history of long lasting antacid taking for gastric ulser or gastritis. Candidiasis must be investigated in patients with gastritis, duodenitis and gastric ulcer, who are refractory to classic therapies and also in patients who have the chronic disease .

  17. Atrophic coarctation of the abdominal aorta.

    Science.gov (United States)

    Wiest, J W; Traverso, L W; Dainko, E A; Barker, W F

    1980-01-01

    Two cases illustrate the clinical manifestations and angiographic findings associated with segmental stenosis of the abdominal aorta. Such lesions represent the chronic occlusive stage of Takayasu's disease, a nonspecific inflammatory arteritis of uncertain etiology. While the disease is considered autoimmune, an infectious process may be involved. Complications typically associated with stenotic lesions of the abdominal aorta are secondary renal hypertension and ischemic symptoms secondary to vascular insufficiency. Surgical correction, the treatment of choice, has achieved excellent results for these well-localized lesions. Secondary renal hypertension was relieved by a spenorenal shunt and the disease has since been controlled with conservative management in the first patient. An aortofemoral bypass graft successfully alleviated the vascular insufficiency in the second patient, although the patient unfortunately expired from a refractory postoperative cardiac complication. Images Fig. 1. Fig. 2. Fig. 3. Fig. 4. PMID:6102453

  18. Relationship between chronic diarrhea with normal colonoscopy findings and terminal ileum lesions

    Institute of Scientific and Technical Information of China (English)

    LI Hongling; WANG Changcheng; LIU Shuqing; XU Dongsheng; ZHANG Ju; CHEN hongmei

    2014-01-01

    Background The causes and mechanisms of chronic diarrhea are complex.This study aimed to explore the relationship between chronic diarrhea with normal colonoscopy findings and terminal ileum lesions.Methods All cases were collected from January 2009 to June 2010.The 40 patients in the patient group had chronic diarrhea with normal colonoscopy findings.Those who had hyperthyroidism,diabetes,chronic pancreatitis,cirrhosis,atrophic gastritis,short bowel syndrome and connective tissue diseases had been excluded.The control group contained 40 healthy individuals without diarrhea.Endoscopy of the terminal ileum was applied in both groups,with the endoscope inserted into terminal ileum for more than 20 cm.The patients diagnosed of chronic diarrhea with terminal ileum lesions were treated with metronidazole and probiotics for 10-14 days.Results Before treatment there were significant differences in endoscopy findings of the terminal ileum between the two groups (P <0.05).In the patient group,endoscopy showed congestion,edema,erosion and ulcers in 29 cases,hyperplasia and enlargement of lymphoid follicles in 10 cases with a maximal diameter of 7-8 mm,and 1 case showed normal endoscopy results.After treatment,35 patients recovered from diarrhea,and terminal ileum lesions disappeared in 30 cases as determined by endoscopy.In the control group,endoscopy showed scattered hyperplasia of lymphoid follicles in 5 cases,and the follicles were small with the maximal diameter being 3 mm.There was no hyperemia,edema,erosion or ulcers.Conclusions Chronic diarrhea patients with normal colonoscopy findings may have lesions in the terminal ileum that can be detected by endoscopy; including hyperemia,erosion,ulcers and lymphoid follicle hyperplasia.Therapeutic effect is good with metronidazole and probiotics.

  19. Multimodal Management of Atrophic Acne Scarring in the Aging Face

    OpenAIRE

    Gerald O’Daniel, T.

    2011-01-01

    Atrophic facial acne scarring is a widely prevalent condition that can have a negative impact on a patient’s quality of life. The appearance of these scars is often worsened by the normal effects of aging. A number of options are available for the treatment of acne scarring, including chemical peeling, dermabrasion, ablative or nonablative laser resurfacing, dermal fillers, and surgical techniques such as subcision or punch excision. Depending on the type and extent of scarring, a multimodal ...

  20. Gastritis Cystica Polyposa with Gastroduodenal Intussuception: A Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Kwak, Soon Hyuk; Bae, Il Hun; Park, Kil Sun; Lee, Seung Young; Jeon, Min Hee; Cho, Bum Sang; Kamg, Min Ho [Dept. of Radilogy, College of Medicine and Medical Research Institute, Chonbuk National University, Chonju (Korea, Republic of); Ryu, Dong Hee [Dept. of Surergy, College of Medicine and Medical Research Institute, Chonbuk National University, Chonju (Korea, Republic of); Lee, Ho Chang [Dept. of Pathology, College of Medicine and Medical Research Institute, Chonbuk National University, Chonju (Korea, Republic of)

    2011-04-15

    Gastritis cystica polyposa is an uncommon benign lesion that normally occurs on the gastric side of a gastroenterostomy site but is rarely found in patients without a prior history of stomach surgery. We report a case of a 41-year-old woman with gastrodeuodenal intussusception due to gastritis cystica polyposa that developed in an unoperated stomach. CT revealed gastroduodenal intussusception and a cystic and solid mass with fat density in the second portion of the duodenum. Surgery and a pathologic examination confirmed gastritis cystica polyposa.

  1. Combination therapy in the management of atrophic acne scars

    Directory of Open Access Journals (Sweden)

    Shilpa Garg

    2014-01-01

    Full Text Available Background: Atrophic acne scars are difficult to treat. The demand for less invasive but highly effective treatment for scars is growing. Objective: To assess the efficacy of combination therapy using subcision, microneedling and 15% trichloroacetic acid (TCA peel in the management of atrophic scars. Materials and Methods: Fifty patients with atrophic acne scars were graded using Goodman and Baron Qualitative grading. After subcision, dermaroller and 15% TCA peel were performed alternatively at 2-weeks interval for a total of 6 sessions of each. Grading of acne scar photographs was done pretreatment and 1 month after last procedure. Patients own evaluation of improvement was assessed. Results: Out of 16 patients with Grade 4 scars, 10 (62.5% patients improved to Grade 2 and 6 (37.5% patients improved to Grade 3 scars. Out of 22 patients with Grade 3 scars, 5 (22.7% patients were left with no scars, 2 (9.1% patients improved to Grade 1and 15 (68.2% patients improved to Grade 2. All 11 (100% patients with Grade 2 scars were left with no scars. There was high level of patient satisfaction. Conclusion: This combination has shown good results in treating not only Grade 2 but also severe Grade 4 and 3 scars.

  2. Collagenous gastritis in the pediatric age

    Directory of Open Access Journals (Sweden)

    Antonio Rosell-Camps

    2015-05-01

    Full Text Available Collagenous gastritis (CG is an uncommon condition known in the pediatric age. It is characterized by the presence of subepithelial collagen bands (> 10 μm associated with lymphoplasmacytic infiltration of the stomach's lamina propria. Symptoms manifested by patients with CG may be common with many other disorders. It typically manifests with epigastralgia, vomiting, and iron deficiency during pre-adolescence. This condition's pathophysiology remains unclear. In contrast to adults, where association with collagenous colitis and other autoimmune conditions is more common, pediatric involvement is usually confined to the stomach. Drugs of choice include proton pump inhibitors and corticoids. A case is reported of a 12-year-old girl with abdominal pain and ferritin deficiency who was diagnosed with CG based on gastric biopsy and experienced a favorable outcome.

  3. Collagenous gastritis in the pediatric age.

    Science.gov (United States)

    Rosell-Camps, Antonio; Riera-Llodrá, Joana María; Colom-Segui, Marina; Zibetti, Sara; Amengual-Antich, Isabel

    2015-05-01

    Collagenous gastritis (CG) is an uncommon condition known in the pediatric age. It is characterized by the presence of subepithelial collagen bands (> 10 microm) associated with lymphoplasmacytic infiltration of the stomach's lamina propria. Symptoms manifested by patients with CG may be common with many other disorders. It typically manifests with epigastralgia, vomiting, and iron deficiency during pre-adolescence. This condition's pathophysiology remains unclear. In contrast to adults, where association with collagenous colitis and other autoimmune conditions is more common, pediatric involvement is usually confined to the stomach. Drugs of choice include proton pump inhibitors and corticoids. A case is reported of a 12-year-old girl with abdominal pain and ferritin deficiency who was diagnosed with CG based on gastric biopsy and experienced a favorable outcome. PMID:25952808

  4. MONITORING OF CASES WITH A CHRONIC PERSISTENT INFECTION WITH HELICOBACTER PYLORI

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    Miglena Stamboliyska

    2014-09-01

    Full Text Available Introduction: The patients with persistent forms of Helicobacter pylori (HP infection are refractory to eradication treatment. They receive unsuccessful therapies, experience frequent recurrences and re-infections. One of the main reasons for the development of persistent forms is an inadequate and insufficient treatment. The persistent forms of HP infection create conditions for the maintenance of activity and for the progression of the induced chronic gastritis. In this aspect these cases will be at a higher risk for the development of gastric cancer. The aim of this study is: to monitor and analyze the cases with persistent HP infection and to establish an approach for their management. Clinical material and methods: The study includes 12 patients (8 female and 4 male at a middle age of 63,7, with a persistent HP infection, who have been observed for a period of five years. Two methods for the detection of HP infection are used – one invasive and one non-invasive. Upper endoscopy with morphological examination was performed. Results: In 9/12 patients HP was unsuccessfully treated for three times, in 2 patients – four times, and in 1 patient – five times. In all patients the initial treatment consisted of a standard triple therapy (STT. In 5 of them STT was conducted twice, with the same regimen for a period of seven days. Two patients received three courses of STT. In four patients an antibiotic resistance was established by means of a cultured assessment. In three cases an HP resistance to Clarithromycine and Metronidazole was demonstrated. Significant gastro-duodenal pathology with atrophic gastritis, intestinal metaplasia, and hyperplastic polyposis was found in all patients. The persistent clinical symptoms had 9 patients. Conclusion: We believe that a devised and proposed step strategy which covers early detection of infection, reliable diagnosis, adequate and successful treatment, and dispensary monitoring, contributes to the

  5. Clinical Significance of Body Surface and Tongue Temperatures and Body Surface Humidity on Diagnosis of Chronic Gastritis of Syndromes of Spleen and Stomach Asthenia-cold and Stomach-yin Deficiency%慢性胃炎脾胃虚寒证与胃阴亏虚证体表温度、湿度及舌温度变化的临床意义

    Institute of Scientific and Technical Information of China (English)

    李果刚; 程建丽; 张妍妤; 王欢

    2011-01-01

    目的:探讨慢性胃炎脾胃虚寒证与胃阴亏虚证患者体表温度、湿度及舌中温度变化的临床意义.方法:运用寒热湿诊测仪测定慢性胃炎脾胃虚寒证和胃阴亏虚证患者的手心、手背、手臂尺肤、额头、舌中温度及手心、手背、手臂尺肤、额头湿度,并与正常志愿者的体表、舌中温度及体表湿度进行比较分析.结果:与正常对照组比较,胃阴亏虚组患者的手心温度、手背温度、尺肤温度、额头温度和舌中温度均显著升高(P<0.05),而脾胃虚寒组患者的手心温度、手背温度、尺肤温度、额头温度则显著降低(P<0.05);脾胃虚寒组患者的手背湿度、尺肤湿度、额头湿度均显著降低(P<0.05).结论:慢性胃炎的虚寒证与虚热证患者其体表温度及湿度存在一定的差异性,通过检测其定量值可能对慢性胃炎虚寒证与虚热证的诊断有一定的参考价值.%Objective: To explore the clinical significance of body surface and tongue temperatures and body surface humidity on diagnosis of chronic gastritis of syndromes of spleen and stomach asthenia-cold and stomach-yin deficiency. Methods: The cold-heat-dampness diagnostic instrument was applied to test the body surface (including the palm, the back of the hand, the forearm and forehead) and tongue temperatures and body surface (including the palm, the back of the hand, the forearm and forehead) humidity of patients with chronic gastritis of syndromes of spleen and stomach asthenia-cold and stomach-yin deficiency, and the temperatures and humidities were compared with the normal volunteers. Results: Compared with the normal control group, the temperatures of the palm, back of the hand, forearm, forehead and tongue in stomach-yin deficiency group increased significantly (P <0.05) , while the temperatures of the palm, back of the hand, forearm and forehead in spleen and stomach asthenia-cold group decreased obviously ( P < 0. 05 ) s the

  6. Gut Feelings About Gastritis: When Your Stomach's Sick

    Science.gov (United States)

    ... disclaimer . Subscribe Gut Feelings About Gastritis When Your Stomach’s Sick Your stomach lining has an important job. It makes acid ... pain or an uncomfortable feeling in their upper stomach. But many other conditions can cause these symptoms. ...

  7. Collagenous gastritis revealed by severe anemia in a child.

    Science.gov (United States)

    Côté, J F; Hankard, G F; Faure, C; Mougenot, J F; Holvoet, L; Cézard, J P; Navarro, J; Peuchmaur, M

    1998-08-01

    Collagenous gastritis is a rare histopathological disorder of unknown origin, characterized by a subepithelial collagen deposit greater than 10 microm thick, associated with an inflammatory infiltrate of the gastric mucosa. This report describes a second pediatric case of collagenous gastritis, revealed by severe anemia caused by gastric bleeding, as was the first case. Unlike the adult cases of collagenous gastritis, lesions were limited to the stomach, and remained unchanged on six series of biopsies taken during a 30 month follow-up, despite treatment with omeprazole, sucralfate and corticosteroids. An immunohistochemical study showed signs of local immune activation on all biopsy specimens, including overexpression of HLA-DR by epithelial cells, increased numbers of CD3+ intraepithelial lymphocytes, and CD25+ cells in the lamina propria. Although the cause of the disease remains unclear, our findings suggest that the histopathological lesions of collagenous gastritis may result from a local immune process. PMID:9712433

  8. Collagenous gastritis: an unusual association with profound weight loss.

    Science.gov (United States)

    Wang, Hanlin L; Shah, Amit G; Yerian, Lisa M; Cohen, Russell D; Hart, John

    2004-02-01

    Collagenous gastritis is a distinctive disorder characterized by thickening of the subepithelial collagen layer in the gastric mucosa. Although this entity was recognized in 1989, its etiology, pathogenesis, and clinicopathologic features remain poorly understood because of its rarity. An unusual case of collagenous gastritis was observed in a 37-year-old man who presented with profound weight loss, a feature that has not previously been emphasized. PMID:14736276

  9. Expressão dos antígenos ABH e Lewis na gastrite crônica e alterações pré- neoplásica da mucosa gástrica Expression of ABH and Lewis antigens in chronic gastritis and pre-neoplasic alterations in gastric mucosa

    Directory of Open Access Journals (Sweden)

    Délia Cristina Figueira Aguiar

    2002-10-01

    Full Text Available RACIONAL: A aderência do Helicobacter pylori à mucosa gástrica humana é pré-requisito para sua colonização e o desenvolvimento da gastrite crônica. Os antígenos de grupos sangüíneos, presentes no muco gástrico, são descritos como prováveis receptores da bactéria neste epitélio. A expressão alterada destes antígenos está associada ao desenvolvimento do câncer gástrico. OBJETIVOS: Verificar a ocorrência do Helicobacter pylori e a distribuição da expressão dos antígenos ABH e Lewis correlacionada com as alterações histopatológicas de pacientes com gastrite crônica. PACIENTES E MÉTODOS: Analisaram-se 63 amostras de sangue, saliva e biopsias gástricas de pacientes com gastrite crônica através das técnicas dot-blot-ELISA, imunoperoxidase indireta e colorações do Gram modificado e hematoxilina-eosina. RESULTADOS: Não foram encontradas associações significativas entre a presença da bactéria e os fenótipos de grupos sangüíneos ABH, Lewis e Secretor. Na maioria dos pacientes, a expressão dos antígenos ABH e Lewis, estava restrita principalmente ao epitélio foveolar da mucosa gástrica, concordando com a expressão ao nível salivar. A expressão inapropriada desses antígenos ocorria sempre na infecção pelo Helicobacter pylori e/ou alterações pré-neoplásicas da mucosa gástrica. Em áreas com metaplasia intestinal foi observada a redução da reatividade para os antígenos H e Le b, e principalmente o aumento de Leª. CONCLUSÃO: Alterações no padrão de glicosilação destes antígenos refletem diferentes estágios de diferenciação celular e são marcadores potenciais na avaliação diagnóstica e prognóstica das patologias gástricas.BACKGROUND:The major cause for chronic gastritis in human is the infection by the Helicobacter pylori. The blood group antigens present at the gastric mucous are described as possible receptor for this bacteria in the epithelium. The alterations in the expression of

  10. Collagenous gastritis: a long-term follow-up with the development of endocrine cell hyperplasia, intestinal metaplasia, and epithelial changes indeterminate for dysplasia.

    Science.gov (United States)

    Winslow, J L; Trainer, T D; Colletti, R B

    2001-11-01

    This report reviews the literature pertaining to collagenous gastritis and describes the clinicopathologic evolution of this disease in a patient during a 12-year period. We examined 109 biopsy specimens of gastric mucosa from 19 different endoscopic procedures for the severity and distribution of collagenous gastritis in a single patient. Assessments were undertaken for the presence of endocrine and gastrin cell hyperplasias and dysplastic epithelial changes. Relative to biopsy specimens from age- and sex-matched control subjects, the patient's biopsy specimens showed a significantly lower number of antral gastrin cells, along with a significant corpus endocrine cell hyperplasia, suggesting an increased risk of endocrine neoplasia. Gastric corpus biopsy specimens revealed an active, chronic gastritis, subepithelial collagen deposition, smooth muscle hyperplasia, and mild to moderate glandular atrophy. Additional findings of intestinal metaplasia and reactive epithelial changes indeterminate for dysplasia raise concerns about the potential for adenocarcinoma. PMID:11710694

  11. Acute phlegmonous gastritis complicated by delayed perforation.

    Science.gov (United States)

    Min, Sun Young; Kim, Yong Ho; Park, Won Seo

    2014-03-28

    Here, we report on a case of acute phlegmonous gastritis (PG) complicated by delayed perforation. A 51-year-old woman presented with severe abdominal pain and septic shock symptoms. A computed tomography scan showed diffuse thickening of the gastric wall and distention with peritoneal fluid. Although we did not find definite evidence of free air on the computed tomography (CT) scan, the patient's clinical condition suggested diffuse peritonitis requiring surgical intervention. Exploratory laparotomy revealed a thickened gastric wall with suppurative intraperitoneal fluid in which Streptococcus pyogenes grew. There was no evidence of gastric or duodenal perforation. No further operation was performed at that time. The patient was conservatively treated with antibiotics and proton pump inhibitor, and her condition improved. However, she experienced abdominal and flank pain again on postoperative day 10. CT and esophagogastroduodenoscopy showed a large gastric ulcer with perforation. Unfortunately, although the CT showed further improvement in the thickening of the stomach and the mucosal defect, the patient's condition did not recover until a week later, and an esophagogastroduodenoscopy taken on postoperative day 30 showed suspected gastric submucosal dissection. We performed total gastrectomy as a second operation, and the patient recovered without major complications. A pathological examination revealed a multifocal ulceration and necrosis from the mucosa to the serosa with perforation.

  12. Paradigm Shift in the Management of the Atrophic Posterior Maxilla

    Directory of Open Access Journals (Sweden)

    Rabah Nedir

    2014-01-01

    Full Text Available When the posterior maxilla is atrophic, the reference standard of care would be to perform sinus augmentation with an autologous bone graft through the lateral approach and delayed implant placement. However, placement of short implants with the osteotome sinus floor elevation technique and without graft can be proposed for an efficient treatment of clinical cases with a maxillary residual bone height of 4 to 8 mm. The use of grafting material is recommended only when the residual bone height is ≤4 mm. Indications of the lateral sinus floor elevation are limited to cases with a residual bone height ≤ 2 mm and fused corticals, uncompleted healing of the edentulous site, and absence of flat cortical bone crest or when the patient wishes to wear a removable prosthesis during the healing period. The presented case report illustrates osteotome sinus floor elevation with and without grafting and simultaneous implant placement in extreme conditions: atrophic maxilla, short implant placement, reduced healing time, and single crown rehabilitation. After 6 years, all placed implants were functional with an endosinus bone gain.

  13. 益生菌联合三联疗法治疗小儿幽门螺杆菌相关性慢性胃炎的临床观察%Effect of probiotics combined with triple therapy clinical value in treatment of Helicobacter pylori associated chronic gastritis

    Institute of Scientific and Technical Information of China (English)

    潘祥龙

    2015-01-01

    Objective To observe the clinical curative effect and prognosis of probiotics combined with tripletherapyforHelicobacterpyloriassociatedchronicgastritis.Methods 110casesofchronicgastritiswere randomized into control group of 50 cases, 60 cases in the treatment group, the control group was given Rabeprazole+amoxicillin+furazolidone triple therapy for 2 weeks, after continue taking Rabeprazole for 2 weeks;the treatment group based on the use of Lactobacillus Complex Capsules;effect evaluation by gastroscopy after 4 weeks;after 1 years of follow-up, to observe the recurrence rate.Results In the control group, 13 cases were cured (26%) , effective in 18 cases ( 36%) , effective 11 cases ( 22%) , invalid 8 cases ( 16%) , the total efficiency was 84%, control group 22 cases were cured (36.7%), 25 cases were cured (41.7%), effective 11 cases (18.3%), invalid 2 cases (3.3%), the total effective rate of treatment group is 96.7%, the effect is better;1 years after the treatment group and control group the rate of recurrence was 22% and 6.7%, the treatment group the recurrence rate is low.Conclusions Probiotic capsules combined with triple therapy for Helicobacter pylori associated chronic gastritis has good effect, and can effectively reduce the recurrence rate.%目的:观察益生菌联合三联疗法治疗小儿幽门螺杆菌相关性慢性胃炎的临床疗效及其预后。方法将110例确诊为慢性胃炎的患儿随机分为对照组50例,治疗组60例,对照组给予雷贝拉唑+阿莫西林+呋喃唑酮三联疗法2周,之后继续服用雷贝拉唑2周;治疗组在此基础上加用复合乳酸菌胶囊;4周后复查胃镜评估效果;1年后随访,观察复发率。结果对照组治愈13例(26.0%),显效18例(36.0%),有效11例(22.0%),无效8例(16.0%),总有效率84.0%。治疗组治愈22例(36.7%),显效25例(41.7%),有效11例(18.3%),无效2例(3.3

  14. A Comparative Clinicopathologic Study of Collagenous Gastritis in Children and Adults: The Same Disorder With Associated Immune-mediated Diseases.

    Science.gov (United States)

    Ma, Changqing; Park, Jason Y; Montgomery, Elizabeth A; Arnold, Christina A; McDonald, Oliver G; Liu, Ta-Chiang; Salaria, Safia N; Limketkai, Berkeley N; McGrath, Kevin M; Musahl, Tina; Singhi, Aatur D

    2015-06-01

    Collagenous gastritis is a rare condition characterized by surface epithelial damage, subepithelial collagen deposition, and a lamina propria inflammatory infiltrate. Previous studies have proposed 2 clinicopathologic subtypes: (1) children (18 y of age or younger) presenting with severe anemia, nodular gastric mucosa, and isolated gastric disease; and (2) adults with chronic watery diarrhea that is associated with diffuse collagenous involvement of the gastrointestinal tract. However, notable exceptions exist. In fact, broad variability in clinical presentation, etiology, treatment and disease course has been reported. To better define the clinicopathologic features of collagenous gastritis, we have collected 10 pediatric and 21 adult cases and describe their clinical, endoscopic, pathologic, and follow-up findings. Both children and adults presented with similar clinical symptoms such as anemia (50%, 35%, respectively), epigastric/abdominal pain (50%, 45%), and diarrhea (40%, 55%). Concomitant immune disorders were identified in 2 (20%) children and 3 (14%) adults. Further, 7 of 17 (41%) adults were taking medications associated with other immune-related gastrointestinal diseases including olmesartan and antidepressants. Histologically, there were no differences between children and adults with collagenous gastritis in the location of gastric involvement, mean collagenous layer thickness, and prominence of eosinophils (P>0.05). Extragastric collagenous involvement was also seen with comparable frequencies in each cohort (44%, 59%). Follow-up information was available for 22 of 31 (71%) patients and ranged from 2 to 122 months (mean, 33.6 mo). Despite medical management in most cases, persistence of symptoms or collagenous gastritis on subsequent biopsies was seen in 100% of children and 82% of adults. Of note, treatment for 1 adult patient involved cessation of olmesartan resulting in resolution of both symptoms and subepithelial collagen deposition on subsequent

  15. Russell body gastritis/duodenitis: a case series and description of immunoglobulin light chain restriction.

    Science.gov (United States)

    Zhang, Hejun; Jin, Zhu; Cui, Rongli

    2014-10-01

    Russell body esophago-gastro-duodenitis is an unusual form of chronic inflammation, with only 22 cases being reported in PubMed. However, the prevalence and clinical significance remain unknown. This report describes the clinico-pathological characteristics of nine cases of Russell body gastritis (RBG) and one case of Russell body duodentitis (RBD), with nonspecific endoscopic appearance. The Mott cells (plasma cells with Russell bodies) showed κ light chain restriction in eight gastritis cases and λ light chain restriction in the duodentitis case, and there were no histological features that suggested lymphoma. Thus, a diagnosis of monoclonal RBG/RBD was made. Helicobacter pylori infection was found in 55.6% of RBG cases and in the RBD case. And, the clinical follow-up evaluations were uneventful. This report is the first study to describe this benign disease entity with monoclonality on a large-scale basis. In addition, the monoclonality of Mott cells cannot be used as evidence of an existing neoplastic lesion, and taken together, these findings may indicate a reactive process. PMID:25001185

  16. Cerebral atrophic and degenerative changes following various cerebral diseases, (1)

    International Nuclear Information System (INIS)

    Patients having cerebral atrophic and degenerative changes following hypoglycemia, cerebral contusion, or cerebral hypoxia including cerebrovascular disorders were reported. Description was made as to cerebral changes visualized on CT images and clinical courses of a patient who revived 10 minutes after heart stoppage during neurosurgery, a newborn with asphyxia, a patient with hypoglycemia, a patient who suffered from asphyxia by an accident 10 years before, a patient with carbon monoxide poisoning at an acute stage, a patient who had carbon monoxide poisoning 10 years before, a patient with diffuse cerebral ischemic changes, a patient with cerebral edema around metastatic tumor, a patient with respiration brain, a patient with neurological sequelae after cerebral contusion, a patient who had an operation to excise right parietal lobe artery malformation, and a patient who was shooted by a machine gun and had a lead in the brain for 34 years. (Tsunoda, M.)

  17. Histopathological profile of gastritis in adult patients seen at a referral hospital in Kenya

    Institute of Scientific and Technical Information of China (English)

    Ahmed Kalebi; Farzana Rana; Walter Mwanda; Geoffrey Lule; Martin Hale

    2007-01-01

    AIM: To conduct a detailed histological study of gastritis in adult patients attending an endoscopy clinic at a Kenyan teaching and referral hospital.METHODS: Biopsy specimens from consecutive patients were examined and graded according to the Updated Sydney System for H pylori infection, chronic inflammation, neutrophil activity, glandular atrophy and intestinal metaplasia. Also documented were gastric tissue eosinophil counts and presence of lymphoid follicles.RESULTS: The rate of the graded variables, in the antrum and corpus respectively, were as follows:H pylori infection (91%, 86%), chronic inflammation (98%, 93%),neutrophil activity (91%, 86%), glandular atrophy (57%,15%) and intestinal metaplasia (11%, 2%). Lymphoid follicles were noted in 11% of cases. Duodenal and gastric ulcers were documented in 32% and 2% respectively.The mean eosinophil count was 5.9 ± 0.74 eosinophils/HPF and 9.58 ± 0.93 eosinophils/HPF in the corpus and antrum respectively. Significant association was found between the degree of H pylori colonisation with chronic inflammation, neutrophil activity and antral glandular atrophy. Biopsies from the antrum and corpus showed significant histopathological discordance for all the graded variables.H pylori negative cases were associated with recent antibiotic use.CONCLUSION: The study reaffirms that H pylori is the chief cause of gastritis in this environment. The majority of patients show a moderate to high degree of inflammation but a low degree of glandular atrophy and intestinal metaplasia. The study shows that interrelationships between the histological variables in this African population are similar to those found in other populations worldwide including non-African populations.

  18. Collagenous gastritis, a new spectrum of disease in pediatric patients: two case reports.

    Science.gov (United States)

    Suskind, David; Wahbeh, Ghassan; Murray, Karen; Christie, Dennis; Kapur, Raj P

    2009-01-01

    Collagenous gastritis is a rare gastrointestinal disorder characterized in pediatrics by abdominal pain and anemia. The literature divides collagenous gastritis into distinct pediatric-onset and adult-onset phenotypes. As opposed to pediatric form, the adult form is associated with collagenous colitis and presents clinically with voluminous non-bloody diarrhea. There are over 25 case reports of collagenous gastritis of which 10 are pediatric cases. We present two cases of pediatric onset collagenous gastritis: one with a classic pediatric presentation, the other with findings typical of adult-onset disease. This is the first report of the adult-onset phenotype collagenous gastritis in a pediatric patient. PMID:19829984

  19. Histological Features and Biocompatibility of Bone and Soft Tissue Substitutes in the Atrophic Alveolar Ridge Reconstruction

    Directory of Open Access Journals (Sweden)

    Carlo Maiorana

    2016-01-01

    Full Text Available The reconstruction of the atrophic alveolar ridges for implant placement is today a common procedure in dentistry daily practice. The surgical reconstruction provides for the optimization of the supporting bone for the implants and a restoration of the amount of keratinized gingiva for esthetic and functional reasons. In the past, tissue regeneration has been performed with autogenous bone and free gingival or connective tissue grafts. Nowadays, bone substitutes and specific collagen matrix allow for a complete restoration of the atrophic ridge without invasive harvesting procedures. A maxillary reconstruction of an atrophic ridge by means of tissue substitutes and its histological features are then presented.

  20. Collagenous gastritis : a rare cause of anaemia in childhood

    OpenAIRE

    Vella, Cecil; Pullicino, Edgar; Fearne, Christopher

    2010-01-01

    We report a thirteen year old boy presenting with severe iron deficiency anaemia. Initial extensive investigation failed to reveal an obvious cause. Subsequently a diagnosis of collagenous gastritis was made. To our knowledge this is the first report of a patient with this rare condition in the Maltese Islands.

  1. Telomere length in non-neoplastic gastric mucosa and its relationship to H. pylori infection, degree of gastritis, and NSAID use.

    Science.gov (United States)

    Tahara, Tomomitsu; Shibata, Tomoyuki; Kawamura, Tomohiko; Ishizuka, Takamitsu; Okubo, Masaaki; Nagasaka, Mitsuo; Nakagawa, Yoshihito; Arisawa, Tomiyasu; Ohmiya, Naoki; Hirata, Ichiro

    2016-02-01

    Telomere shortening occurs with human aging in many organs and tissues and is accelerated by rapid cell turnover and oxidative injury. We measured average telomere length using quantitative real-time PCR in non-neoplastic gastric mucosa and assessed its relationship to H. pylori-related gastritis, DNA methylation, ulcer disease, and nonsteroidal anti-inflammatory drug (NSAID) usage. Gastric biopsies were obtained from 151 cancer-free subjects including 49 chronic NSAID users and 102 nonusers. Relative telomere length in genomic DNA was measured by real-time PCR. H. pylori infection status, histological severity of gastritis, and serum pepsinogens (PGs) were also investigated. E-cadherin (CDH1) methylation status was determined by methylation-specific PCR (MSP). Average relative telomere length of H. pylori-infected subjects was significantly shortened when compared to H. pylori-negative subjects (p = 0.002) and was closely associated with all histological parameter of gastritis (all p values telomere length than nonusers (p = 0.028). Shorter telomere length was observed in duodenal and gastric ulcer patients compared with non-ulcer subjects among NSAID users. Telomere shortening is closely associated with severity of H. pylori-induced gastritis and CDH1 methylation status. Also, telomere shortening is accelerated by NSAID usage especially in H. pylori-negative subjects.

  2. Investigation on Relationship between Different Helicobacter pylori Antibodies and Gastric Cancer,Peptic Ulcer and Chronic Gastritis in Xinjiang Area%幽门螺杆菌不同抗体与新疆地区胃癌、消化性溃疡和慢性胃炎的关系

    Institute of Scientific and Technical Information of China (English)

    王新国; 李莉; 高峰

    2016-01-01

    Background:Helicobacter pylori( Hp)is the main cause of chronic gastritis( CG),and CagA and VacA are important pathogenic factors of Hp. Recent studies have indicated that CagA and VacA antibodies of Hp have close relationship with gastric cancer(GC)and peptic ulcer(PU). Aims:To investigate the relationship between different antibodies of Hp and GC,PU and CG in Xinjiang area. Methods:Eighty-four GC,108 PU and 196 CG patients from Jan. 2014 to Aug. 2014 were enrolled. 14 C-urea breath test was used to determine Hp infection. Hp was typed by immunoblotting technique. Relationship between different Hp antibodies and patients with GC,PU and CG was analyzed. Results:Type Ⅰ Hp-positive rate in GC,PU and CG groups was decreased stepwisely(47. 6% ,37. 0% ,21. 4% , respectively). The positive rates of Hp strains(CagA-128 kDa,VacA-110 kDa and UreB-66 kDa)differed significantly among GC,PU,and CG groups(P = 0. 013,P = 0. 011,P = 0. 002);GC was associated with CagA-128 kDa,VacA-110 kDa,VacA-90 kDa and UreB-66 kDa(P < 0. 05),PU was associated with VacA-110 kDa,UreB-66 kDa(P < 0. 05). UreB-66 kDa was the risk factor of PU and GC(P < 0. 05). Conclusions:GC is associated with CagA-128 kDa,VacA-110 kDa,VacA-90 kDa and UreB-66 kDa,PU is associated with VacA-110 kDa,UreB-66 kDa,and UreB-66 kDa is the risk factor of PU and GC.%背景:幽门螺杆菌(Hp)是公认的慢性胃炎(CG)的主要原因,CagA 和 VacA 为 Hp 的重要致病因子。最近研究发现 VacA 抗体、CagA 抗体与胃癌(GC)、消化性溃疡(PU)相关。目的:探讨 Hp 不同抗体与新疆地区 GC、PU 和CG 的关系。方法:收集2014年1月—2014年8月84例 GC、108例 PU、196例 CG 患者,以14 C-尿素呼气试验检测Hp 感染,免疫印迹技术检测 Hp 分型,分析入选患者与 Hp 不同抗体的关系。结果:GC 组 Hp Ⅰ型感染率为47.6%,PU 组为37.0%,CG 组为21.4%,呈递减趋势。GC、PU 和 CG 组间 CagA-128 kDa、VacA-110 kDa 和 UreB-66 k

  3. Practical Evaluation and Management of Atrophic Acne Scars: Tips for the General Dermatologist

    OpenAIRE

    Fife, Douglas

    2011-01-01

    Atrophic acne scarring is an unfortunate, permanent complication of acne vulgaris, which may be associated with significant psychological distress. General dermatologists are frequently presented with the challenge of evaluating and providing treatment recommendations to patients with acne scars. This article reviews a practical, step-by-step approach to evaluating the patient with atrophic acne scars. An algorithm for providing treatment options is presented, along with pitfalls to avoid. A ...

  4. Modified ridge splitting technique using conical space maintainers for delayed implant placement in highly atrophic maxillae.

    OpenAIRE

    Cabanes Gumbau, Guillermo; Silvestre Donat, Francisco Javier

    2010-01-01

    Background: A low-morbidity surgical technique is described for the horizontal augmentation of highly atrophic alveolar ridges in which first surgical step implant placement is contraindicated. The aim of this case report was to present an alternative treatment for the rehabilitation of the atrophic maxilla. Methods: The technique involves a crestal corticotomy with transverse expansion of the vestibular and lingual cortical layers, followed by the placement of threaded titaniu...

  5. Biological markers in Helicobacter pylori-associated gastritis and carcinoma: the value of a scoring system

    International Nuclear Information System (INIS)

    Helicobacter pylori-associated gastritis has been linked to the pathogenesis of gastric adenocarcinoma (GA), especially when assciated with intestinal metaplasia (IM) and atypia/dysplasia (A/D). We examined p53 expression, ploidy and proliferative activity and assessed H.pylori infection in relationship to IM and A/Din case of gastritis not associated with GA and in cases of GA. We examined 53 gastric biopsies from patients with gastritis not associated with GA, including patients with IM and/or A/D (n=35) and with gastritis associated with IM and/or A/D (n=21). Thirty-six distal gastrectomy specimens from patients with GA constituted a third group of patients. A scoring system that encompassed the presence or absence of H.Pylori, degree of gastritis, IM and/or A/D, p53, MIB-1prolefarative index (MPI) and ploidy was estimated in the cases of gastritis and in cancer associated mucosa (CAM) and the adenocarcinoma from patients withGA. Patients with GA had a higher median age than those with gastritis without IM and more were males (ratio 2.2:1). H.pylori was detected in 75% (40/53) of gastritis specimen and in 55% (20/36) of GA cases. There was a statistically significant difference between the incidence of gastritis without IM and/or A/D and CAM (p=0.01). p53 expression was seen in 67% of the cases (14/21) of gastritis with IM and/or A/D and only in 5% (2 cases ) of gastritis without IM (p=0.0005). A statistically significant difference in MPI was seen between CAM and GA (p=0.01) and gastritis without IM and/or A/D and gastritis with IM(p=0.004). Cases of gastritis without IM and/or or A/D has a median score of 8 while cases of gastritis with IM and/or A/D had a median score of 12 (p=0.0003). CAM had a median score of 13, which was significantly different than gastritis without IM and/or A/D(p=0.0003) The presence of IM and/or A/D can be used in H.pylori -associated gastritis as as starting point to further investigate high risk lesions. Those showing p53 expression

  6. Risk factor analysis for metaplastic gastritis in Koreans

    Institute of Scientific and Technical Information of China (English)

    Soonami Choi; Yun Jeong Lim; Sue Kyung Park

    2006-01-01

    AIM: To conduct a retrospective study to determine the risk factors for development of metaplastic gastritis in Korean population.METHODS: The database of 113449 subjects who underwent a gastroscopy for the purpose of a regular check-up at center for health promotion, Samsung medical center during 5 years was collected and retrospectively analyzed. Among them, 5847 subjects who had endoscopically diagnosed as a metaplastic gastritis or 10076 normal as well as answered to questionnaire were included for present study. The subjects were divided into 2 groups; Group Ⅰ, normal and Group Ⅱ, metaplastic gastritis. Age, gender, Helicobacter pylori(H pylori) seropositivity, body mass index (BMI),family history of cancer, smoking, alcohol consumption,total daily calories, folate and salt intake and dietary habit (out-eating, overeating, irregular eating) were retrieved from questionnaire or electronic medical record and compared between group Ⅰ and group Ⅱ.RESULTS: The prevalence of group Ⅱ was 11%(13578/113449) increasing its prevalence with age(P= 0.000). But, there was no significant association between 2 groups in BMI, family history of cancer,alcohol consumption, total daily calories, folate and salt intake and dietary habit (out-eating, overeating, irregular eating). Old age (P=0.000), male gender (P=0.000),H pylori seropositivity (P= 0.010) and current smoker (P= 0.000) were significantly more common in group Ⅱ at multiple logistic regression model.CONCLUSION: Our data suggested that old age, male gender,Hpyloriseropositivity and smoking were risk factors for metaplastic gastritis, precancerous lesion of gastric cancer.

  7. Biopsy specimen appearances of ischaemic gastritis in splanchnic arterial insufficiency.

    OpenAIRE

    Trowell, J E; Bell, G. D.

    1998-01-01

    A 74 year old man presented with a one month history of epigastric discomfort, anorexia, weight loss, and postprandial vomiting. The diagnosis of ischaemia was made on endoscopic biopsies from the stomach and duodenum. He was too ill for major vascular surgery and died eight days after admission. Postmortem examination confirmed the diagnosis of splanchnic arterial insufficiency caused by atheroma and thrombosis. Ischaemic gastritis is rare but could easily be missed in unrepresentative biops...

  8. [Phlegmonous gastritis. Report of a case induced by Pseudomonas aeruginosa].

    Science.gov (United States)

    Ramos Jiménez, F A; Arocena Cedrón, M G; Goikoetxea Artola, J M; Lázaro Aramburu, S; Múgica Barreiros, P

    1992-06-01

    The authors present a case of phlegmonous gastritis in a 65 year old patient. The diagnosis was made in the operating room and the treatment was conservative; no gastric resection was done. This clinical entity is interesting because it is a least frequent pathology, the pathogenic bacteria which was the cause (Pseudomona aeruginosa) has at this time not been reported in the literature, including the favorable outcome of the patient without gastric resection. PMID:1633018

  9. 慢性浅表性胃炎脾虚与脾胃湿热证患者物质能量代谢基因差异表达研究%Study on Gene Differential Expressions of Substance and Energy Metabolism in Chronic Superficial Gastritis Patients of Pi Deficiency Syndrome and of Pi-Wei Hygropyrexia Syndrome

    Institute of Scientific and Technical Information of China (English)

    杨泽民; 陈蔚文; 王颖芳

    2012-01-01

    metabolic levels of energy and substance in chronic superficial gastri-tis (CSG) patients of Pi deficiency syndrome (PDS) and of Pi-Wei hygropyrexia syndrome (PWHS), including lip-id, protein, nucleic acid, carbohydrate, trace element, and energy metabolism, and to study the pathogenesis mechanism of PDS from substance and energy metabolisms. Methods Recruited were 8 CSG patients who visited at First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine and Guangdong Provincial Hos-pital of Traditional Chinese Medicine from June 2004 to March 2005, including 4 patients of PDS and 4 of PWHS. Their gastric mucosae were used for experiments of DNA microarray. The dual-channel DNA microarray data were bioinformatically analyzed by BRB ArrayTools and IPA Software. Results Obtained were fifty-six differentially ex-pressed genes involved in substance and energy metabolisms with the expression fold more than 2, including 11 genes up-regulated and 45 genes down-regulated. Of them, genes correlated to lipid metabolism included CRLS1,LRP11, FUT9, GPCPD1, PIGL, SULT1A4, B3GNT1, ST8SIA4, and ACADVL, mainly involved in the metabolic processes of fatty acid, cholesterol, phospholipids, and glycolipid. Genes correlated to protein metabolism included ASRGL1, AARSD1, EBNA1BP2, PUM2, MRPL52, C120RF65, PSMB8, PSME2, UBA7, RNF11, FBXO44, ZFYVE26, CHMP2A, SSR4, SNX4, RAB3B, RABL2A, G0LGA2, KDELR1, PHPT1, ACPP, PTPRF, CRKL, HDAC7, ADPRHL2, B3GNT1, ST8SIA4, DDOST, and FUT9, mainly involved in the biosynthesis processes of pro-tein, ubiquitination, targeted transport and post-translation modification. Genes correlated to nucleic acid metabo-lism included DFFB, FLJ35220, T0P2A, SF3A3, CREB3, CRTC2, NR1D2, MED6, GTF2IRD1, C1ORF83, ZNF773, and ZMYND11, mainly involved in DNA replication and repair, transcription regulation. Genes correlated to carbohydrate metabolism included AGL, B3GNT1, FUT9, ST8SIA4, SULT1A4, DDOST, and PIGL, mainly in-volved in glucogen degradation and

  10. Chronic giardiasis of the stomach.

    OpenAIRE

    Quincey, C.; James, P.D.; Steele, R. J.

    1992-01-01

    Two cases of chronic giardiasis of the stomach diagnosed from gastric mucosal biopsy specimens are reported. The first case was associated with an acute-on-chronic gastritis and Helicobacter-like organisms, and the second with an adenocarcinoma of the stomach. In both cases the trophozoites had been missed in earlier biopsy specimens. As far as is known this is the first report of giardiasis of the stomach.

  11. Brugia filariasis differentially modulates persistent Helicobacter pylori gastritis in the gerbil model

    OpenAIRE

    Martin, Heather R.; Shakya, Krishna P.; MUTHUPALANI, SURESHKUMAR; Ge, Zhongming; Klei, Thomas R.; Whary, Mark T.; James G Fox

    2010-01-01

    In select Helicobacter pylori-infected populations with low gastric cancer, nematode coinfections are common and both helicobacter gastritis and filariasis are modeled in gerbils. We evaluated gastritis, worm counts, tissue cytokine gene expression levels and Th1/Th2-associated antibody responses in H. pylori and Brugia pahangi mono- and coinfected gerbils. H. pylori-associated gastritis indices were significantly lower 21 weeks post-infection in coinfected gerbils (p ≤ 0.05) and were inverse...

  12. Collagenous gastritis, a new spectrum of disease in pediatric patients: two case reports

    OpenAIRE

    Suskind, David; Wahbeh, Ghassan; Murray, Karen; Christie, Dennis; Kapur, Raj P.

    2009-01-01

    Collagenous gastritis is a rare gastrointestinal disorder characterized in pediatrics by abdominal pain and anemia. The literature divides collagenous gastritis into distinct pediatric-onset and adult-onset phenotypes. As opposed to pediatric form, the adult form is associated with collagenous colitis and presents clinically with voluminous non-bloody diarrhea. There are over 25 case reports of collagenous gastritis of which 10 are pediatric cases. We present two cases of pediatric onset coll...

  13. Classification of histological severity of Helicobacter pylori-associated gastritis by confocal laser endomicroscopy

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    AIM: To classify the histological severity of Helicobacter pylori (H. pylori) infection-associated gastritis by confocal laser endomicroscopy (CLE). METHODS: Patients with upper gastrointestinal symptoms or individuals who were screened for gastric cancer were enrolled in this study. Histological severity of H. pylori infection-associated gastritis was graded according to the established CLE criteria. Diagnostic value of CLE for histo-logical gastritis was investigated and compared with that of white light ...

  14. Severely Atrophic Human Muscle Fibers With Nuclear Misplacement Survive Many Years of Permanent Denervation.

    Science.gov (United States)

    Carraro, Ugo; Kern, Helmut

    2016-06-13

    Likewise in rodents, after complete spinal cord injury (SCI) the lower motor neuron (LMN) denervated human muscle fibers lose completely the myofibrillar apparatus and the coil distribution of myonuclei that are relocated in groups (nuclear clumps) in the center of severely atrophic muscle fibers. Up to two years of LMN denervation the muscle fibers with nuclear clumps are very seldom, but in this cohort of patients the severely atrophic muscle fibers are frequent in muscle biopsies harvested three to six years after SCI. Indeed, the percentage increased to 27 ± 9% (pbehavior in long term denervated muscle fibers. PMID:27478559

  15. The diagnosis and pathogenesis of chronic alcoholic myopathy

    Directory of Open Access Journals (Sweden)

    Yu. V. Kazantseva

    2013-01-01

    Full Text Available Peripheral neuromuscular apparatus lesion is a common complication of chronic alcohol intoxication. Alcohol-induced skeletal muscle diseaseis least studied now. A comprehensive clinical, neurophysiological, and morphological examination was made in 42 patients with chronic alcoholintoxication during this study. All the patients underwent skeletal muscle biopsy followed by muscle fiber morphometry. There was both selective type 2 muscle fiber atrophy and diffuse types 1 and 2 muscle fiber atrophic changes. The clinical manifestations of skeletal muscle disease corresponded to the degree of an atrophic process. There was impairment in the main components of protein synthesis at both intracellular and systemic regulation levels.

  16. Gastritis cystica polyposa in the unoperated stomach: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Yeo Jin; Kim, Kyung Ah; Chung, Yong Eun; Lim, Joon Seok; Jeon, Hyae Min [Severance Hospital/Yonsei Univ. College of Medicine, Seoul (Korea, Republic of)

    2012-10-15

    Gastritis cystica polyposa (GCP) is an uncommon lesion that usually develops at the gastroenterostomy site. A 57 year old man visited a hospital with a complaint of melena. He did not have any surgical history or past medical history. Endoscopy was performed to evaluate the cause of melena, and a polypoid cystic mass in the stomach was found on an endoscopy and endoscopic ultrasonography. The polypoid cystic mass did not show any enhancing solid portion on a computed tomography. The gastric lesion was conclusively confirmed as GCP through endoscopic submucosal dissection. We report a rare case of GCP that occurred in an unoperated stomach.

  17. Autoimmune gastritis and parietal cell reactivity in two children with abnormal intestinal permeability

    NARCIS (Netherlands)

    Greenwood, Deanne L. V.; Crock, Patricia; Braye, Stephen; Davidson, Patricia; Sentry, John W.

    2008-01-01

    Autoimmune gastritis is characterised by lymphocytic infiltration of the gastric submucosa, with loss of parietal and chief cells and achlorhydria. Often, gastritis is expressed clinically as cobalamin deficiency with megaloblastic anaemia, which is generally described as a disease of the elderly. H

  18. Successful Treatment of Collagenous Gastritis in a Child With a Gluten-Free Diet.

    Science.gov (United States)

    Bajwa, Raza U; Joshi, Aditya; Heikenen, Janice B

    2015-12-01

    Collagenous gastritis is a rarely encountered disease entity first described in 1989, and it is very rarely reported in children. We report the case of a 13-year-old boy with clinical, endoscopic, and histological findings of collagenous gastritis who reported rapid and sustained symptom resolution on a gluten-free diet. PMID:26854316

  19. Helicobacter pylori-associated gastritis and dyspepsia. The influence on migrating motor complexes

    DEFF Research Database (Denmark)

    Qvist, N; Rasmussen, L; Axelsson, C K

    1994-01-01

    Twenty-five patients with dyspepsia were included. In 19 patients with a median age of 48 (range, 20-72) years endoscopy and histologic examination of biopsy specimens from the antrum and corpus of the stomach showed Helicobacter pylori-positive gastritis as the only pathologic finding. In six......-positive gastritis. Nine patients were reexamined after eradication of the H. pylori infection, and the motility pattern had changed to the characteristics found in normals. In conclusion, the patients with dyspepsia and gastritis showed a disturbed motility pattern. The disturbance was similar whether there was...... patients with a median age of 42 (range, 32-56) years H. pylori-negative gastritis was found. After an overnight fast the patients underwent an ambulatory duodenal motility study for 6-8 h. Twenty-five young healthy men served as the control group. In patients with H. pylori-positive gastritis the duration...

  20. Collagenous gastritis in a Korean child: a case report.

    Science.gov (United States)

    Park, Sanghui; Kim, Dong Hoon; Choe, Youn Ho; Suh, Yeon-Lim

    2005-02-01

    Collagenous gastritis, a counterpart of collagenous colitis, is an extremely rare disorder. The first case of collagenous gastritis in a Korean boy in his pre-teens who had been receiving treatment for refractory iron deficiency anemia has been reported. The patient had been suffering from intermittent abdominal pain, recurrent blood-tinged vomiting and poor oral intake. The gastric endoscopy revealed diffuse cobblestone appearance of the mucosa with easy touch bleeding throughout the stomach but no abnormalities in the esophagus, duodenum, and colon. Pathologic examination of the gastric biopsies from the antrum, body and cardia showed a subepithelial collagen deposition with entrapped dilated capillaries, moderate infiltrates of lympho-plasma cells and eosinophils of the lamina propria, and marked hypertrophy of the muscularis mucosa. The collagen deposition appeared as discontinuous bands with focally irregular extension into the deeper part of the antral mucosa. It measured up to 150 microm. Helicobacter pylori infection was not detected. The biopsies from the duodenum, esophagus and colon revealed no pathologic abnormalities. PMID:15716621

  1. Dominant inherited distal spinal muscular atrophy with atrophic and hypertrophic calves

    NARCIS (Netherlands)

    Groen, R J; Sie, O G; van Weerden, T W

    1993-01-01

    The clinical, electrophysiological, radiological and morphological data of 3 members of a family with autosomal dominant distal spinal muscular atrophy (DSMA) are reported. One patient has the clinical picture of peroneal muscular atrophy with atrophic calves. His father and sister suffer from cramp

  2. A Comparative Evaluation of Low-Level Laser and Topical Steroid Therapies for the Treatment of Erosive-Atrophic Lichen Planus

    Directory of Open Access Journals (Sweden)

    Hanaa M. Elshenawy

    2015-08-01

    Full Text Available BACKGROUND: Oral lichen planus (OLP is a chronic inflammatory disease that causes bilateral white striations, papules, or plaques on the buccal mucosa, tongue, and gingivae. Erythema, erosions, and blisters may or may not be present. Several empirical therapies have been used in the treatment of (OLP. OBJECTIVE: To evaluate the effect of low level laser therapy (LLLT versus topical steroids for the treatment of erosive-atrophic lichen planus. SUBJECTS AND METHODS: Twenty-four patients with erosive-atrophic (OLP were categorized into two groups. In the first group patients were treated with 970nm diode laser irradiation, while, in the second group patients used topical corticosteroids (0.1% triamcinolone acetonide orabase. The gender, medical history and pain score were recorded. The pain score was measured before and after treatment by visual analogue scale (VAS. RESULTS: Steroid-treated group (0.1% triamcinolone acetonide orabase show reduced pain score than laser group. CONCLUSION: Topical steroids are more effective than LLLT. LLLT may be used as an alternative treatment for symptomatic OLP when steroids are contraindicated.

  3. Russell Body Gastroenteritis: An Aberrant Manifestation of Chronic Inflammation in Gastrointestinal Mucosa

    Directory of Open Access Journals (Sweden)

    Feriyl Bhaijee

    2013-01-01

    Full Text Available First described in 1998, Russell body gastritis is a rare chronic inflammatory condition characterized by abundant intramucosal polyclonal plasma cells, which contain intracytoplasmic eosinophilic globules of immunoglobulins (Russell bodies that displace the nucleus, with an accompanying chronic inflammatory infiltrate. Russell bodies represent a cellular response to overstimulation of plasma cells, leading to the accumulation of abundant, nondegradable, condensed immunoglobulin in dilated rough endoplasmic reticulum cisternae. Russell body gastritis usually occurs in the gastric antrum, but two cases of Russell body duodenitis have been recently described. Herein, we report an unusual case of Barrett esophagus with prominent lymphoplasmacytic infiltration and Russell bodies, which expands the current spectrum of Russell body gastritis/duodenitis. Given the various anatomic locations in which Russell body gastritis may arise, we suggest that “Russell body gastroenteritis” may be a more appropriate designation for this uncommon reactive condition.

  4. ИММУНОГИСТОХИМИЧЕСКИЕ ПРЕДПОСЫЛКИ ПРОГРЕССИРОВАНИЯ ХРОНИЧЕСКОГО H. PYLORI-АССОЦИИРОВАННОГО ГАСТРИТА В MALT-ЛИМФОМУ ЖЕЛУДКА

    Directory of Open Access Journals (Sweden)

    КОРОЛЕВА И.А.

    2014-01-01

    Full Text Available The aim of the study was to identify new mechanisms of MALT-lymphoma of the stomach in patients with chronic H. pylori-associated gastritis. The article shows that the lowest level of the expression of Ki-67 and the molecule Bcl-2 is observed in lymphoid follicles of gastric mucosa in patients with chronic non-atrophic H. pylori-associated gastritis. Expression of Ki-67 and Bcl-2 has consistently increased in patients with chronic atrophic H. pylori-associated gastritis, reaching maximum values in patients with MALT-lymphoma of the stomach, which allows us to consider this as an option in the tumor progression of H. pylori-associated gastritis. The data obtained are able to improve the forecasting of H. pylori-associated gastritis.

  5. Adaptive cytoprotection through modulation of nitric oxide in ethanol-evoked gastritis

    Institute of Scientific and Technical Information of China (English)

    Joshua Ka-Shun Ko; Chi-Hin Cho; Shiu-Kum Lam

    2004-01-01

    AIM: To assess the mechanisms of protective action by different mild irritants through maintenance of gastric mucosal integrity and modulation of mucosal nitric oxide (NO) in experimental gastritis rats.METHODS: Either 200 ml/L ethanol, 50 g/L NaCl or 0.3 mol/LHCl was pretreated to normal or 800 mL/L ethanol-induced acute gastritis Sprague-Dawley rats before a subsequent challenge with 500 mL/L ethanol. Both macroscopic lesion areas and histological damage scores were determined in the gastric mucosa of each group of animals. Besides,gastric mucosal activities of NO synthase isoforms and of superoxide dismutase, along with mucosal level of leukotriene (LT)C4 were measured.RESULTS: Macroscopic mucosal damages were protected by 200 mL/L ethanol and 50 g/L NaCl in gastritis rats.However, although 200 mL/L ethanol could protect the surface layers of mucosal cells in normal animals (protection attenuated by NG-nitro-L-arginine methyl ester), no cytoprotection against deeper histological damages was found in gastritis rats. Besides, inducible NO synthase activity was increased in the mucosa of gastritis animals and unaltered by mild irritants. Nevertheless, the elevation in mucosal LTC4 level following 500 mL/L ethanol administration and under gastritis condition was significantly reduced by pretreatment of all three mild irritants in both normal and gastritis animals.CONCLUSION: These findings suggest that the aggravated 500 mL/L ethanol-evoked mucosal damages under gastritis condition could be due to increased inducible NO and LTC4 production in the gastric mucosa. Only 200 mL/L ethanol is truly "cytoprotective" at the surface glandular level of nongastritis mucosa. Furthermore, the macroscopic protection of the three mild irritants involves reduction of LTC4 level in both normal and gastritis mucosa, implicating preservation of the vasculature.

  6. [Simultaneous occurrence of lymphocytic gastritis and lymphocytic colitis with transition to collagenous colitis].

    Science.gov (United States)

    Christ, A D; Meier, R; Bauerfeind, P; Wegmann, W; Gyr, K

    1993-07-31

    Lymphocytic gastritis and lymphocytic colitis are two rare disorders of unknown etiology, only diagnosable by histology. Simultaneous occurrence of lymphocytic colitis and lymphocytic gastritis has not been described up to now. A 69-year-old female patient was examined because of crampy abdominal pain and watery diarrhea. Laboratory tests did not reveal an etiology and in colonoscopy the colon and terminal ileum were normal. Histology disclosed lymphocytic colitis. Esophagogastroduodenoscopy showed erosive bulbitis. Biopsies of the stomach revealed lymphocytic gastritis. A second colonoscopy one year later showed the development of collagenous colitis. PMID:8367708

  7. A case of radiation gastritis required surgical treatment in consequence of radiotherapy for recurrent ovarian cancer

    Energy Technology Data Exchange (ETDEWEB)

    Hagino, Daisuke; Arai, Yuko; Komatsu, Atsushi; Inoue, Kumiko; Takechi, Kimihiro [Ibaraki Prefectural Central Hospital, Tomobe (Japan)

    2002-12-01

    We report a case of radiation gastritis in consequence of radiotherapy for recurrent ovarian cancer. A 61-year-old woman received irradiation of a metastatic lesion of the second lumbar vertebra. Six months later she complained of fatigue and presented with severe anemia, and her diagnosis was hemorrhagic radiation gastritis. She was treated endoscopically, but that failed to control the bleeding, making it necessary to resect surgically. The incidence of radiation gastritis is very low because the stomach is rarely within the treated field, but it is of importance to be aware that the stomach is by no means more radioresistant than other organs. (author)

  8. The Effect of Pimecrolimus Cream 1% Compared with Triamcinolone Acetonide Paste in Treatment of Atrophic-Erosive Oral Lichen Planus

    Directory of Open Access Journals (Sweden)

    Atessa Pakfetrat

    2015-03-01

    Full Text Available Introduction: Oral lichen planus (OLP is a common chronic mucocutaneous disease. Patients with atrophic and erosive types of OLP often have symptoms of soreness, and require proper treatment. The main treatment for OLP has been the administration of topical or systemic corticosteroids. The objective of this study was to compare the efficacy of adcortyl cream (triamcinolone acetonide in orabase with topical pimecrolimus cream for the treatment of erosive OLP.   Materials and Methods: Twenty-eight patients with OLP were enrolled in a single blind clinical trial and assigned to either a pimecrolimus 1% cream group or an adcortyl 0.1% cream group. The medication was applied every day for 2 months and patients were assessed every 2 weeks.   Results: The mean lesion size and mean pain and burning sensation scores did not differ between the pimecrolimus and adcortyl cream groups. The pimecrolimus cream was well tolerated. No clinical drug-related adverse events were observed.   Conclusion:  Topical pimecrolimus cream may be recommended as a safe and effective alternative therapy in the treatment of OLP. Pimecrolimus cream is as effective as adcortyl cream in managing the signs and symptoms of OLP.

  9. Coordinate increase of telomerase activity and c-Myc expression in Helicobacter pylori-associated gastric diseases

    Institute of Scientific and Technical Information of China (English)

    Guo-Xin Zhang; Yan-Hong Gu; Zhi-Quan Zhao; Shun-Fu Xu; Hong-Ji Zhang; Hong-Di Wang; Bo Hao

    2004-01-01

    AIM: To detect the telomerase activity and c-Myc expression in gastric diseases and to examine the relation between these values and Helicobacter pylori (H pylori) as a risk factor for gastric cancer.METHODS: One hundred and seventy-one gastric samples were studied to detect telomerase activity using a telomerase polymerase chain reaction enzyme linked immunosorbent assay (PCR-ELTSA), and c-Myc expression using immunohistochemistry.RESULTS: The telomerase activity and c-Myc expression were higher in cancers (87.69% and 61.54%) than in noncancerous tissues. They were higher in chronic atrophic gastritis with severe intestinal metaplasia (52.38% and 47.62%) than in chronic atrophic gastritis with mild intestinal metaplasia (13.33% and 16.67%). Tn chronic atrophic gastritis with severe intestinal metaplasia, the telomerase activity and c-Myc expression were higher in cases with -H pylori infection (67.86% and 67.86%) than in those without infection (21.43%and 7.14%). c-Myc expression was higher in gastric cancer with H pylori infection (77.27%) than in that without infection (28.57%). The telomerase activity and c-Nyc expression were coordinately up-regulated in H pylori infected gastric cancer and chronic atrophic gastritis with severe intestinal metaplasia.CONCLUSION: H pylori infection may influence both telomerase activity and c-Myc expression in gastric diseases,especially in chronic atrophic gastritis.

  10. Association between efficient adhesion to HEp-2 cells and severity of gastritis in Helicobacter pylori strains isolated from children

    Directory of Open Access Journals (Sweden)

    Tahereh Falsafi

    2009-01-01

    Full Text Available Background and objectives: Helicobacter pylori causes chronic gastritis, peptic ulceration, and is a risk factor for gastric cancer. More than half of the world`s population is infected with this pathogen, however the disease outcome varies. Among the virulence factors of H. pylori, specific adhesions to gastric epithelium may be an important step in the induction of active inflammation. H. pylori displays considerable genetic diversity attributed to genetic drift during long-term colonization. Heterogeneity of clinical-isolates has considerably impacted in understanding the role of each factor in infection outcome. However, genetic change may be more limited in the stomach of children in the short period after infection. This work evaluates differences in adherence potential of strains isolated from children with various chronic- inflammation status."nMaterials and Methods: A total of 157 children admitted to Medical Center of Tehran for upper gastrointestinal problems underwent endoscopy for H. pylori infection. Histological examination of their biopsies was performed after H& E and Giemsa staining. Gastritis and inflammation were graded according to the updated Sydney system. 70 culture-positive children, 20 were selected according to their histopathological status. Adherence of their H. pylori isolates to HEp- 2 cells was evaluated by viable count of bacteria associated with host cells in an optimized procedure developed in this study."nResults: Correlation was seen between inflammation severity score and efficiency of adhesion to HEp-2 cells. This correlation was not observed in the KB cell line as an epithelial cell-model."nConclusion: Specific interaction of H. pylori with host gastric epithelium may be associated with disease outcome

  11. Helicobacter pylori infection, glandular atrophy and intestinal metaplasia in superficial gastritis, gastric erosion, erosive gastritis, gastric ulcer and early gastric cancer

    Institute of Scientific and Technical Information of China (English)

    Chuan Zhang; Nobutaka Yamada; Yun-Lin Wu; Min Wen; Takeshi Matsuhisa; Norio Matsukura

    2005-01-01

    AIM: To evaluate the histological features of gastric mucosa, including Helicobacter pylori infection in patients with early gastric cancer and endoscopically found superficial gastritis, gastric erosion, erosive gastritis,gastric ulcer.METHODS: The biopsy specimens were taken from the antrum, corpus and upper angulus of all the patients.Giemsa staining, improved toluidine-blue staining, and H pylori-specific antibody immune staining were performed as appropriate for the histological diagnosis of H pylori infection. Hematoxylin-eosin staining was used for the histological diagnosis of gastric mucosa inflammation, gastric glandular atrophy and intestinal metaplasia and scored into four grades according to the Updated Sydney System.RESULTS: The overall prevalence of H pylori infection in superficial gastritis was 28.7%, in erosive gastritis 57.7%,in gastric erosion 63.3%, in gastric ulcer 80.8%, in early gastric cancer 52.4%. There was significant difference (P<0.05), except for the difference between early gastric cancer and erosive gastritis. H pylori infection rate in antrum, corpus, angulus of patients with superficial gastritis was 25.9%, 26.2%, 25.2%, respectively; in patients with erosive gastritis 46.9%, 53.5%, 49.0%,respectively; in patients with gastric erosion 52.4%, 61.5%,52.4%, respectively; in patients with gastric ulcer 52.4%,61.5%, 52.4%, respectively; in patients with early gastric cancer 35.0%, 50.7%, 34.6%, respectively. No significant difference was found among the different site biopsies in superficial gastritis, but in the other diseases the detected rates were higher in corpus biopsy (P<0.05). The grades of mononuclear cell infiltration and polymorphonuclear cell infiltration, in early gastric cancer patients, were significantly higher than that in superficial gastritis patients, lower than that in gastric erosion and gastric ulcer patients (P<0.01);however, there was no significant difference compared with erosive gastritis. The grades

  12. Detection of Helicobacter spp. in the saliva of dogs with gastritis.

    Science.gov (United States)

    Jankowski, M; Spużak, J; Kubiak, K; Glińska-Suchocka, K; Biernat, M

    2016-01-01

    The aim of this study was to identify the species and determine the prevalence of gastric Helicobacter in the saliva of dogs with gastritis. The study was carried out on 30 dogs of different breeds, genders and ages, which were diagnosed with gastritis. The nested-PCR method was used to detect Helicobacter spp. in saliva. Helicobacter bacteria were found in the saliva samples of 23 (76.6%) dogs. Helicobacter heilmannii was the most commonly detected species of gastric Helicobacter spp. in canine saliva, and was found in 22 (73.3%) cases. The results indicate that gastric Helicobacter spp. occurs relatively frequently in dogs with gastritis. Moreover, the saliva of dogs with gastritis may be a source of Helicobacter spp. infection for humans and other animals. However, further studies are needed to confirm this finding as the PCR method does not distinguish active from inactive infections. PMID:27096797

  13. Epithelial cell proliferation and glandular atrophy in lymphocytic gastritis: Effect of H pylori treatment

    Institute of Scientific and Technical Information of China (English)

    Johanna M. Makinen; Seppo Niemela; Tuomo Kerola; Juhani Lehtola; Tuomo J. Karttunen

    2003-01-01

    AIM: Lymphocytic gastritis is commonly ass ociated with Helicobacter pylori infection. The presence of glandular atrophy and foveolar hyperplasia in lymphocytic gastritis suggests abnormalities in cell proliferation and differentiation,forming a potential link with the suspected association with gastric cancer. Our aim was to compare epithelial cell proliferation and morphology in H pylori associated lymphocytic gastritis and H pylori gastritis without features of lymphocytic gastritis,and to evaluate the effect of H pylori treatment.METHODS: We studied 14 lymphocytic gastritis patients with H pylori infection. For controls, we selected 14 matched dyspeptic patients participating in another treatment trial whose H pylori infection had successfully been eradicated.Both groups were treated with a triple therapy and followed up with biopsies for 6-18 months (patients) or 3 months (controls). Blinded evaluation for histopathological features was carried out. To determine the cell proliferation index,the sections were labeled with Ki-67 antibody.RESULTS: Before treatment, lymphocytic gastritis was characterized by foveolar hyperplasia (P=0.001) and glandular atrophy in the body (P=0.008), and increased proliferation in both the body (P=0.001) and antrum (P=0.002). Proliferation correlated with foveolar hyperplasia and inflammation activity. After eradication therapy, the number of intraepithelial lymphocytes decreased in the body (P=0.004)and antrum (P=0.065), remaining higher than in controls (P<0.001). Simultaneously, the proliferation index decreased in the body from 0.38 to 0.15 (P=0.043), and in the antrum from 0.34 to 0.20 (P=0.069), the antral index still being higher in lymphocytic gastritis than in controls (P=0.010).Foveolar hyperplasia and glandular atrophy in the body improved (P=0.021), reaching the non-LG level.CONCLUSION: In lymphocytic gastritis, excessive epithelial cell proliferation is predominantly present in the body, where it associates with

  14. Major motor atrophic patterns in the face and neck: CT evaluation

    International Nuclear Information System (INIS)

    Cranial nerve deficits from various pathologic processes of the head and neck may result in characteristic patterns of denervation muscular atrophy. Such atrophic patterns may be clues to the location and extent of the lesion, particularly when cranial nerves are involved early in the course of the disease process. Thirty-six patients with computed tomographic (CT) evidence of muscular atrophy secondary to pathologic conditions involving the motor division of cranial nerves were examined. Five characteristic denervation muscular atrophy patterns seen on CT scans were identified. Recognition of these atrophic patterns can prevent misinterpretation of their CT appearance and direct the CT examination to the course of the compromised cranial nerve from the brainstem to its peripheral innervation

  15. Endoscopic diagnosis of cytomegalovirus gastritis after allogeneic hematopoietic stem cell transplantation

    Institute of Scientific and Technical Information of China (English)

    Yasuo; Kakugawa; Masahiro; Kami; Takahisa; Matsuda; Yutaka; Saito; Sung-Won; Kim; Takahiro; Fukuda; Shin-ichiro; Mori; Tadakazu; Shimoda; Ryuji; Tanosaki; Daizo; Saito

    2010-01-01

    AIM:To clarify the endoscopic and clinical findings of cytomegalovirus(CMV) gastritis after allogeneic hematopoietic stem cell transplantation(allo-SCT).METHODS:Between 1999 and 2005,523 patients underwent allo-SCT at our hospital,and 115 of these patients with gastrointestinal symptoms underwent esophagogastroduodenoscopy.RESULTS:CMV gastritis was diagnosed pathologically in seven patients(1.3%) with the other 108 patients serving as controls.Six of the seven patients developed positive CMV antigenemia,and...

  16. Identification of Helicobacter pylori DNA in the mouths and stomachs of patients with gastritis using PCR.

    OpenAIRE

    Mapstone, N P; Lynch, D A; Lewis, F. A.; Axon, A T; Tompkins, D S; Dixon, M. F.; Quirke, P.

    1993-01-01

    AIMS--To determine the prevalence of Helicobacter pylori colonisation in the mouths of patients with H pylori gastritis. METHODS--A nested polymerase chain reaction test for the 16S ribosomal RNA gene of H pylori was used on saliva, dental plaque, gastric juice and gastric biopsy specimens from patients attending a dyspepsia clinic. RESULTS--Thirteen patients had histologically confirmed Helicobacter associated gastritis. Twelve of these had positive gastric aspirates by PCR. Five had at leas...

  17. Proteomic analysis reveals molecular biological details in varioliform gastritis without Helicobacter pylori infection

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    AIM:To investigate and elucidate the molecular mechanism underlying varioliform gastritis for early detection,prevention and intervention of gastric cancer.METHODS:A combination of two-dimensional gel electrophoresis and mass spectrometry was used to detect the differentially expressed proteins between varioliform gastritis and matched normal mucosa.The selected proteins were confirmed by Western blotting and reverse transcription polymerase chain reaction(RT-PCR) in additional samples and the function of s...

  18. Serum IL-10, MMP-7, MMP-9 Levels in Helicobacter pylori Infection and Correlation with Degree of Gastritis

    OpenAIRE

    Gontar Siregar; Sahat Halim; Ricky Sitepu

    2016-01-01

    AIM: Helicobacter pylori causes gastric mucosal inflammation and immune reaction. However, the increase of IL-10, MMP-7, and MMP-7 levels in the serum is still controversial. The objective of this study was to investigate the serum levels of IL-10, MMP-7 & MMP-9 in gastritis patients with H. pylori infection. MATERIALS AND METHODS: A cross-sectional study was done on seventy gastritis patients that consecutive admitted to endoscopy units. The diagnosis of gastritis was made based on histo...

  19. Serum IL-10, MMP-7, MMP-9 Levels in Helicobacter pylori Infection and Correlation with Degree of Gastritis

    OpenAIRE

    Siregar, Gontar; Halim, Sahat; Sitepu, Ricky

    2016-01-01

    AIM: Helicobacter pylori causes gastric mucosal inflammation and immune reaction. However, the increase of IL-10, MMP-7, and MMP-7 levels in the serum is still controversial. The objective of this study was to investigate the serum levels of IL-10, MMP-7 & MMP-9 in gastritis patients with H. pylori infection.MATERIALS AND METHODS: A cross-sectional study was done on seventy gastritis patients that consecutive admitted to endoscopy units. The diagnosis of gastritis was made based on histopatho...

  20. Russell Body Gastroenteritis: An Aberrant Manifestation of Chronic Inflammation in Gastrointestinal Mucosa

    OpenAIRE

    Feriyl Bhaijee; Brown, Keith A.; Long, Billy W.; Brown, Alexandra S.

    2013-01-01

    First described in 1998, Russell body gastritis is a rare chronic inflammatory condition characterized by abundant intramucosal polyclonal plasma cells, which contain intracytoplasmic eosinophilic globules of immunoglobulins (Russell bodies) that displace the nucleus, with an accompanying chronic inflammatory infiltrate. Russell bodies represent a cellular response to overstimulation of plasma cells, leading to the accumulation of abundant, nondegradable, condensed immunoglobulin in dilated r...

  1. Disappearance of Helicobacter without Antibiotics in 12 Patients with Gastritis

    Directory of Open Access Journals (Sweden)

    Hugh James Freeman

    1997-01-01

    Full Text Available Detection of Helicobacter pylori in endoscopic gastric biopsies has been associated with a variety of diseases, including ulcers and gastritis. Although the natural history of H pylori in the gastric mucosa is unknown, antibiotic regimens have been used for eradication. Gastric biopsies from 6050 endoscopic procedures done by a single gastroenterologist from 1981 to 1994 were evaluated. Of these, 2860 from April 1, 1991 to September 30, 1994 had silver-stained biopsies to facilitate H pylori detection, and at least two upper endoscopic procedures were done with gastric biopsies in 188 patients. Twelve of the 188 patients with an initially positive H pylori gastric biopsy became H pylori-negative without antibiotic treatment for H pylori or other infection; 10 received omeprazole and two received no drug treatment. In two of the 12 patients recurrent H pylori in the gastric mucosa was also documented. These findings indicate that H pylori may disappear and reappear in the gastric mucosa with no specific antibiotic eradication regimen, although omeprazole may eradicate H pylori in vivo in some patients. The natural history of H pylori in gastric biopsies is poorly understood. Improved understanding, especially regarding the pathogenesis of upper gastrointestinal ulcerative and inflammatory disease processes, is essential before recommendations for specific antibiotic eradication regimens can be made.

  2. Vitamin C, gastritis, and gastric disease: a historical review and update.

    Science.gov (United States)

    Aditi, Anupam; Graham, David Y

    2012-10-01

    The discovery of Helicobacter pylori as the cause of gastritis and peptic ulcers ushered in the modern era of research into gastritis and into acid-peptic diseases and rekindled interest in the role of ascorbic acid in the pathophysiology and treatment of gastritis and peptic ulcer disease. Here, we review historic and modern studies on ascorbic acid and gastric diseases with an emphasis on H. pylori gastritis and its sequelae. The relationship of ascorbic acid and gastritis and peptic ulcer and its complications was extensively studied during the 1930s through the 1950s. Much of this extensive literature has been effectively "lost." Ascorbic acid deficiency was associated with all forms of gastritis (e.g., autoimmune, chemical, and infectious) due in varying degrees to insufficient intake, increased metabolic requirements, and destruction within the GI tract. Importantly, gastritis-associated abnormalities in gastric ascorbic acid metabolism are reversed by H. pylori-eradication and potentially worsened by proton pump inhibitor therapy. Diets rich in naturally occurring ascorbic acid are associated with protection of the gastric corpus from atrophy and a reduction in the incidence of gastric cancer possibly through the ability of ascorbic acid to reduce oxidative damage to the gastric mucosa by scavenging carcinogenic N-nitroso compounds and free radicals and attenuating the H. pylori-induced inflammatory cascade. Ascorbic acid supplementation was possibly associated with a decreased incidence of bleeding from peptic ulcer disease. Pharmacologic doses of ascorbic acid also may improve the effectiveness of H. pylori-eradication therapy. Occasionally, looking back can help plot the way forward. PMID:22543844

  3. Fractional CO 2 laser resurfacing as monotherapy in the treatment of atrophic facial acne scars

    Directory of Open Access Journals (Sweden)

    Imran Majid

    2014-01-01

    Full Text Available Background: While laser resurfacing remains the most effective treatment option for atrophic acne scars, the high incidence of post-treatment adverse effects limits its use. Fractional laser photothermolysis attempts to overcome these limitations of laser resurfacing by creating microscopic zones of injury to the dermis with skip areas in between. Aim: The aim of the present study is to assess the efficacy and safety of fractional CO 2 laser resurfacing in atrophic facial acne scars. Materials and Methods: Sixty patients with moderate to severe atrophic facial acne scars were treated with 3-4 sessions of fractional CO 2 laser resurfacing at 6-week intervals. The therapeutic response to treatment was assessed at each follow up visit and then finally 6 months after the last laser session using a quartile grading scale. Response to treatment was labelled as ′excellent′ if there was >50% improvement in scar appearance and texture of skin on the grading scale while 25-50% response and <25% improvement were labelled as ′good′ and ′poor′ response, respectively. The overall satisfaction of the patients and any adverse reactions to the treatment were also noted. Results: Most of the patients showed a combination of different morphological types of acne scars. At the time of final assessment 6 months after the last laser session, an excellent response was observed in 26 patients (43.3% while 15 (25% and 19 patients (31.7% demonstrated a good and poor response respectively. Rolling and superficial boxcar scars responded the best while pitted scars responded the least to fractional laser monotherapy. The commonest reported adverse effect was transient erythema and crusting lasting for an average of 3-4 and 4-6 days, respectively while three patients developed post-inflammatory pigmentation lasting for 8-12 weeks. Conclusions: Fractional laser resurfacing as monotherapy is effective in treating acne scars especially rolling and superficial boxcar

  4. ASSESSMENT OF MICRONEEDLING THERAPY IN THE MANAGEMENT OF ATROPHIC FACIAL ACNE SCARS

    Directory of Open Access Journals (Sweden)

    Ajay

    2015-12-01

    Full Text Available STUDY BACKGROUND Post acne scars are always a challenge to treat, especially the ones which are deep seated. There are many treatment options like laser resurfacing, dermabrasion, microdermabrasion and non-ablative laser resurfacing but with considerable morbidity and interference with the daily activities of the patient in the post-treatment period. Microneedling or dermaroller therapy is one of the new treatment options in the management of acne scars with satisfactory improvement and no significant side effect. The aim of the present study is to perform an objective evaluation the efficacy of microneedling in the treatment of atrophic acne scars. MATERIALS AND METHODS Thirty patients of skin type III-V having atrophic facial acne scars presenting to our dermatology OPD. were received multiple sittings of microneedling (dermaroller treatment with an interval of 6 weeks between each session. Goodman & Baron’s acne scar grading system was used for assessment of their scars and was evaluated clinically by serial photography at the start as well as at two months after the conclusion of the treatment. Patients on anticoagulant therapy, of keloidal tendency, with bleeding disorders, vitiligo patients, pregnant and lactating mothers and patients with active acne lesions were excluded from the study. The duration of this study was for ten months-from January 2014 to October 2014. RESULTS Any change in the grading of scars after the end of treatment and follow-up period was noted down. The efficacy and improvement of dermaroller treatment was assessed by Goodman and Baron’s Global Acne Scarring System. Out of 30 patients, 26(80.64% patients achieved a reduction in the severity of their scarring by one or two grades. Quantitative assessment showed that 13.3% of patients had minimal, 16.6% had good and 70% showed very good improvement. Adverse effects were limited to transient pain, erythema and edema. CONCLUSION Microneedling therapy seems to be

  5. Treatment of radiation-induced hemorrhagic gastritis with prednisolone: A case report

    Institute of Scientific and Technical Information of China (English)

    Lan Zhang; Xiao-Ying Xie; Yan Wang; Yan-Hong Wang; Yi Chen; Zheng-Gang Ren

    2012-01-01

    Radiation-induced gastritis is an infrequent cause of gastrointestinal bleeding.It is a serious complication arising from radiation therapy,and the standard treatment method has not been established.The initial injury is characteristically acute inflammation of gastric mucosa.We presented a 46-year-old male patient with hemorrhagic gastritis induced by external radiotherapy for metastatic retroperitoneal lymph node of hepatocellular carcinoma.The endoscopic examination showed diffuse edematous hyperemicmucosa with telangiectasias in the whole muscosa of the stomach and duodenal bulb.Mlultiple hemorrhagic patches with active oozing were found over the antrum.Anti-secretary therapy was initiated for hemostasis,but melena still occurred off and on.Finally,he was successfully treated by prednisolone therapy.We therefore strongly argue in favor of perdnisolone therapy to effectively treat patients with radiation-induced hemorrhagic gastritis.

  6. Use of Fourier-transform infrared spectroscopy to rapidly diagnose gastric endoscopic biopsies

    Institute of Scientific and Technical Information of China (English)

    Qing-Bo Li; Xue-Jun Sun; Yi-Zhuang Xu; Li-Min Yang; Yuan-Fu Zhang; Shi-Fu Weng; Jing-Sen Shi; Jin-Guang Wu

    2005-01-01

    AIM: To determine if Fourier-transform infrared (FT-IR)spectroscopy of endoscopic biopsies could accurately diagnose gastritis and malignancy.METHODS: A total of 123 gastroscopic samples, including 11 cases of cancerous tissues, 63 cases of chronic atrophic gastritis tissues, 47 cases of chronic superficial gastritis tissues and 2 cases of normal tissues, were obtained from the First Hospital of Xi'an Jiaotong University, China. A modified attenuated total reflectance (ATR) accessory was linked to a WQD-500 FT-IR spectrometer for spectral measurement followed by submission of the samples for pathologic analysis. The spectral characteristics for different types of gastroscopic tissues were summarized and correlated with the corresponding pathologic results.RESULTS: Distinct differences were observed in the FTIR spectra of normal, atrophic gastritis, superficial gastritis and malignant gastric tissues. The sensitivity of FT-IR for detection of gastric cancer, chronic atrophic gastritis and superficial gastritis was 90.9%, 82.5%, 91.5%, and specificity was 97.3%, 91.7%, 89.5% respectively.CONCLUSION: FT-IR spectroscopy can distinguish gastric inflammation from malignancy.

  7. Clinical outcome of pediatric collagenous gastritis: case series and review of literature.

    Science.gov (United States)

    Hijaz, Nadia Mazen; Septer, Seth Steven; Degaetano, James; Attard, Thomas Mario

    2013-03-01

    Collagenous gastritis (CG) is characterized by patchy subepithelial collagen bands. Effective treatment and the clinical and histological outcome of CG in children are poorly defined. The aim of this study is to summarize the published literature on the clinical outcome and response to therapy of pediatric CG including two new cases. We performed a search in Pubmed, OVID for related terms; articles including management and clinical and/or endo-histologic follow up information were included and abstracted. Reported findings were pooled in a dedicated database including the corresponding data extracted from chart review in our patients with CG. Twenty-four patients were included (17 females) with a mean age of 11.7 years. The clinical presentation included iron deficiency anemia and dyspepsia. The reported duration of follow up (in 18 patients) ranged between 0.2-14 years. Despite most subjects presenting with anemia including one requiring blood transfusion, oral iron therapy was only documented in 12 patients. Other treatment modalities were antisecretory measures in 13 patients; proton pump inhibitors (12), or histamine-2 blockers (3), sucralfate (5), prednisolone (6), oral budesonide in 3 patients where one received it in fish oil and triple therapy (3). Three (13%) patients showed no clinical improvement despite therapy; conversely 19 out of 22 were reported with improved symptoms including 8 with complete symptom resolution. Spontaneous clinical resolution without antisecretory, anti-inflammatory or gastroprotective agents was noted in 5 patients (4 received only supplemental iron). Follow up endo-histopathologic data (17 patients) included persistent collagen band and stable Mononuclear cell infiltrate in 12 patients with histopathologic improvement in 5 patients. Neither collagen band thickness nor mononuclear cell infiltrate correlated with clinical course. Intestinal metaplasia and endocrine cell hyperplasia were reported (1) raising the concern of long

  8. Evaluation of the Pattern of EPIYA Motifs in the Helicobacter pylori cagA Gene of Patients with Gastritis and Gastric Adenocarcinoma from the Brazilian Amazon Region.

    Science.gov (United States)

    Vilar E Silva, Adenielson; Junior, Mario Ribeiro da Silva; Vinagre, Ruth Maria Dias Ferreira; Santos, Kemper Nunes; da Costa, Renata Aparecida Andrade; Fecury, Amanda Alves; Quaresma, Juarez Antônio Simões; Martins, Luisa Caricio

    2014-01-01

    The Helicobacter pylori is associated with the development of different diseases. The clinical outcome of infection may be associated with the cagA bacterial genotype. The aim of this study was to determine the EPIYA patterns of strains isolated from patients with gastritis and gastric adenocarcinoma and correlate these patterns with the histopathological features. Gastric biopsy samples were selected from 384 patients infected with H. pylori, including 194 with chronic gastritis and 190 with gastric adenocarcinoma. The presence of the cagA gene and the EPIYA motif was determined by PCR. The cagA gene was more prevalent in patients with gastric cancer and was associated with a higher degree of inflammation, neutrophil activity, and development of intestinal metaplasia. The number of EPIYA-C repeats showed a significant association with an increased risk of gastric carcinoma (OR = 3.79, 95% CI = 1.92-7.46, and P = 0.002). A larger number of EPIYA-C motifs were also associated with intestinal metaplasia. In the present study, infection with H. pylori strains harboring more than one EPIYA-C motif in the cagA gene was associated with the development of intestinal metaplasia and gastric adenocarcinoma but not with neutrophil activity or degree of inflammation. PMID:26904732

  9. Evaluation of the Pattern of EPIYA Motifs in the Helicobacter pylori cagA Gene of Patients with Gastritis and Gastric Adenocarcinoma from the Brazilian Amazon Region

    Directory of Open Access Journals (Sweden)

    Adenielson Vilar e Silva

    2014-01-01

    Full Text Available The Helicobacter pylori is associated with the development of different diseases. The clinical outcome of infection may be associated with the cagA bacterial genotype. The aim of this study was to determine the EPIYA patterns of strains isolated from patients with gastritis and gastric adenocarcinoma and correlate these patterns with the histopathological features. Gastric biopsy samples were selected from 384 patients infected with H. pylori, including 194 with chronic gastritis and 190 with gastric adenocarcinoma. The presence of the cagA gene and the EPIYA motif was determined by PCR. The cagA gene was more prevalent in patients with gastric cancer and was associated with a higher degree of inflammation, neutrophil activity, and development of intestinal metaplasia. The number of EPIYA-C repeats showed a significant association with an increased risk of gastric carcinoma (OR = 3.79, 95% CI = 1.92–7.46, and P=0.002. A larger number of EPIYA-C motifs were also associated with intestinal metaplasia. In the present study, infection with H. pylori strains harboring more than one EPIYA-C motif in the cagA gene was associated with the development of intestinal metaplasia and gastric adenocarcinoma but not with neutrophil activity or degree of inflammation.

  10. Clinical Observation on the Method of Supplementing Qi, Clearing away Heat and Promoting Blood Circulation for Treating 53 Cases of Gastritis Related to Pyrolic Helicobacterium

    Institute of Scientific and Technical Information of China (English)

    汪悦

    2003-01-01

    According to the clinical experience of professor Shan Zhaowei (单兆伟), the author has successfully developed Qingyou Yangwei Capsule (清幽养胃胶囊capsules for eliminating pyrolic Helicobacterium and nourishing the stomach) for treating the gastritis. Clinical research has shown that the capsule has a good curative effect on chronic gastritis related to pyrolic Helicobacterium. Among the 53 cases in the treatment group, clinical observation showed cure in 6 cases, obvious effect in 18 cases, effect in 24 cases, no effect on 5 cases, with a total effective rate of 90.5%. Of the 50 cases in the control group, cure was found in 5 cases, obvious effect in 13 cases, effect in 20 cases, no effect in 12 cases, the total effective rate being 76%. The total effective rate in the treatment group was higher than that in the control group. The rate of eliminating pyrolic Helicobacterium in the treatment group was 66.04%, similar to that in the control group. In a follow-up visit 6 months later, the recurrence rate in the treatment group was 13.33%, obviously lower than that of 41.66% in the control group.

  11. A two-short-implant-supported molar restoration in atrophic posterior maxilla: A finite element analysis

    Science.gov (United States)

    2016-01-01

    PURPOSE The aim of this study was to investigate the stress distribution of 2-short implants (2SIs) installed in a severely atrophic maxillary molar site. MATERIALS AND METHODS Three different diameters of internal connection implants were modeled: narrow platform (NP), regular platform (RP), and wide platform (WP). The maxillary first molars were restored with one implant or two short implants. Three 2SI models (NP-oblique, NP-vertical, and NP-horizontal) and four single implant models (RP and WP in a centered or cantilevered position) were used. Axial and oblique loadings were applied on the occlusal surface of the crown. The von Mises stress values were measured at the bone-implant, peri-implant bone, and implant/abutment complex. RESULTS The highest stress distribution at the bone-implant interface and the peri-implant bone was noticed in the RP group, and the lowest stress distribution was observed in the 2SI groups. Cantilevered position showed unfavorable stress distribution with axial loading. 2SI types did not affect the stress distribution in oblique loading. The number and installation positions of the implant, rather than the bone level, influenced the stress distribution of 2SIs. The implant/abutment complex of WP presented the highest stress concentration while that of 2SIs showed the lowest stress concentration. CONCLUSION 2SIs may be useful for achieving stable stress distribution on the surrounding bone and implant-abutment complex in the atrophic posterior maxilla.

  12. Chronic urticaria and Helicobacter pylori

    Directory of Open Access Journals (Sweden)

    Yadav Mukesh

    2008-04-01

    Full Text Available Background: Helicobacter pylori (HP have recently emerged as a novel eliciting factor for chronic urticaria (CU. The possible association between HP and CU has enormous potential, as eradicating HP could cure CU. Aims and Objectives: We conducted a study to assess the prevalence of HP infection and effect of bacterium eradication on skin lesions in patients of chronic idiopathic urticaria (CIU. Settings and Design: Four hundred sixty patients of CU attending the allergy clinic, SMS hospital, Jaipur during the period February 6, 2004, to February 6, 2006, were screened for possible eliciting factors. Patients with CIU were enrolled and others were excluded. Materials and Methods: Sixty-eight patients of CIU and similar number of age and sex matched controls, attending the allergy clinic, SMS Hospital, Jaipur were enrolled in the study. All patients underwent endoscopy with antral biopsy for urease and histopathology to identify HP-associated gastritis. Infected patients were given HP eradication therapy. Eradication of bacterium was confirmed by fecal antigen assay. Subjective response to treatment was judged using chronic urticaria quality-of-life questionnaire (CU-Q 2 oL while objective response to treatment was judged by need for ′rescue medication′ (antihistaminics. Statistical Analysis: Data were analyzed using Chi square and paired′t′ test for their level of significance. Results: HP associated gastritis was present in 48 (70.58% patients, out of which 39 (81.25% patients responded to eradication therapy. Ten (50.00% patients without HP associated gastritis showed response to symptomatic therapy. Overall 49 (72.05% patients responded and 19 (27.94% showed no response. The value of χ2 was 28.571 (P = 0.003, which showed significant association between presence of HP and response to eradication regimen. Conclusion: The response of HP eradication therapy in infected patients of CIU is significant. HP should be included in diagnostic

  13. Metachronous gastric cancer after successful Helicobacter pylori eradication.

    Science.gov (United States)

    Shiotani, Akiko; Haruma, Ken; Graham, David Y

    2014-09-01

    The high incidence of gastric cancer in Japan initially resulted in establishment of a country-wide gastric cancer screening program to detect early and treatable cancers. In 2013 countrywide Helicobacter pylori (H. pylori) eradication was approved coupled with endoscopy to assess for the presence of chronic gastritis. Current data support the notion that cure of the infection in those with non-atrophic gastritis will prevent development of gastric cancer. However, while progression to more severe damage is halted in those who have already developed, atrophic gastritis/gastric atrophy remain at risk for subsequent development of gastric cancer. That risk is directly related to the extent and severity of atrophic gastritis. Methods to stratify cancer risk include those based on endoscopic assessment of the atrophic border, histologic grading, and non-invasive methods based on serologic testing of pepsinogen levels. Continued surveillance is required because those with atrophic gastritis/gastric atrophy retain considerable gastric cancer risk even after H. pylori eradication. Those who have already experienced a resectable early gastric cancer are among those at highest risk as metachronous lesions are frequent even after H. pylori eradication. We review the role of H. pylori and effect of H. pylori eradication indicating the incidence and the predictive factors on development of metachronous cancer after endoscopic therapy of early gastric cancer. Studies to refine risk markers to stratify for risk, surveillance methods, intervals, and duration after successful H. pylori eradication, and whether adjuvant therapy would change risk are needed. PMID:25206262

  14. Curcuma aromatica Water Extract Attenuates Ethanol-Induced Gastritis via Enhancement of Antioxidant Status

    Directory of Open Access Journals (Sweden)

    Woo-Young Jeon

    2015-01-01

    Full Text Available Curcuma aromatica is an herbal medicine and traditionally used for the treatment of various diseases in Asia. We investigated the effects of C. aromatica water extract (CAW in the stomach of rats with ethanol-induced gastritis. Gastritis was induced in rats by intragastric administration of 5 mL/kg body weight of absolute ethanol. The CAW groups were given 250 or 500 mg of extract/kg 2 h before administration of ethanol, respectively. To determine the antioxidant effects of CAW, we determined the level of lipid peroxidation, the level of reduced glutathione (GSH, the activities of catalase, degree of inflammation, and mucus production in the stomach. CAW reduced ethanol-induced inflammation and loss of epithelial cells and increased the mucus production in the stomach. CAW reduced the increase in lipid peroxidation associated with ethanol-induced gastritis (250 and 500 mg/kg, p<0.01, resp. and increased mucosal GSH content (500 mg/kg, p<0.01 and the activity of catalase (250 and 500 mg/kg, p<0.01, resp.. CAW increased the production of prostaglandin E2. These findings suggest that CAW protects against ethanol-induced gastric mucosa injury by increasing antioxidant status. We suggest that CAW could be developed for the treatment of gastritis induced by alcohol.

  15. Pneumonia and gastritis in a cat caused by feline herpesvirus-1.

    Science.gov (United States)

    McGregor, Glenna F; Sheehan, Karen; Simko, Elemir

    2016-02-01

    We report a case of fatal respiratory and gastric herpesvirus infection in a vaccinated, adult cat with no known immunosuppression or debilitation. The disease was characterized by severe necrotizing bronchopneumonia, fibrinonecrotic laryngotracheitis, and multifocal necrotizing gastritis associated with eosinophilic intranuclear inclusion bodies and a large amount of feline herpesvirus-1 antigen detected with immunohistochemistry.

  16. Analysis of Pathogenic Factors of Helicobacter Pylori in a High Prevalence Area of Gastric Cancer in Xinin,Qinghai Province

    Institute of Scientific and Technical Information of China (English)

    YuanzhiXiong; WeihongYang; YingcaiMa; GuiyingYang; YonggengYang; LiliMa

    2004-01-01

    OBJECTIVE To analyze positive rates of the specific proteins CagA, VacA, UreA and UreB of Helicobacter pylori (Hp) in people in Xinin city Qinghai Province, a district with a high prevalence of gastric carcinoma, and to examine the relationship among the incidence, gross diagnosis and pathologic diagnosis. METHODS The gastric tissue biopsy specimens taken under endoscopy were examined by CLO,WS and Western Blot to judge the condition of the Hp infection. The positive rates of Hp CagA,VacA,UreA and UreB that had infected patients were evaluated. RESULTS The positive rate of UreA was markedly lower in chronic superficial gastritis (CSG) than in duodenal ulcer (DU) and compound ulcer, and also lower than in chronic atrophic gastritis(CAG), gastric ulcer(GU) and gastric cancinoma. However the positive rate of UreB was notably lower in duodenal ulcer and gastric ulcer than in chronic superficial gastritis and atrophic gastritis. The rates of UreB found in intestinal epithelial metaplasia, atrophic gastritis and gastric carcinoma were notably lower than in other diseases, however, it was markedly increased in chronic superficial gastritis, No differences were found among CagA and VacA of specimens with different endoscopic diagnosis or pathologic diagnosis. CONCLUSIONS The UreA in Hp may be relevant to the pathogenic mechanism of severe gastric diseases. However, UreB may have some protective effect on severe gastric diseases.

  17. Operative link for gastritis assessment vs operative link on intestinal metaplasia assessment

    Institute of Scientific and Technical Information of China (English)

    Massimo Rugge; Matteo Fassan; Marco Pizzi; Fabio Farinati; Giacomo Carlo Sturniolo; Mario Plebani; David Y Graham

    2011-01-01

    AIM: To compare the reliability of gastritis staging systems in ranking gastritis-associated cancer risk in a large series of consecutive patients.METHODS: Gastric mucosal atrophy is the precancerous condition in which intestinal-type gastric cancer (GC) most frequently develops. The operative link for gastritis assessment (OLGA) staging system ranks the GC risk according to both the topography and the severity of gastric atrophy (as assessed histologically on the basis of the Sydney protocol for gastric mucosal biopsy). Both cross-sectional and long-term follow-up trials have consistently associated OLGA stages Ⅲ-Ⅳ with a higher risk of GC. A recently-proposed modification of the OLGA staging system (OLGIM) basically incorporates the OLGA frame, but replaces the atrophy score with an assessment of intestinal metaplasia (IM) alone. A series of 4552 consecutive biopsy sets (2007-2009) was retrieved and reassessed according to both the OLGA and the OLGIM staging systems. A set of at least 5 biopsy samples was available for all the cases considered.RESULTS: In 4460 of 4552 cases (98.0%), both the high-risk stages (Ⅲ + Ⅳ) and the low-risk stages (0 +Ⅰ + Ⅱ) were assessed applying the OLGA and OLGIM criteria. Among the 243 OLGA high-risk stages, 14 (5.8%) were down-staged to a low risk using OLGIM. The 67 (1.5%) incidentally-found neoplastic lesions (intraepithelial or invasive) were consistently associated with high-risk stages, as assessed by both OLGA and OLGIM (P < 0.001 for both). Two of 34 intestinal-type GCs coexisting with a high-risk OLGA stage (stage Ⅲ) were associated with a low-risk OLGIM stage (stage Ⅱ).CONCLUSION: Gastritis staging systems (both OLGA and OLGIM) convey prognostically important information on the gastritis-associated cancer risk. Because of its clinical impact, the stage of gastritis should be included as a conclusive message in the gastritis histology report. Since it focuses on IM alone, OLGIM staging is less sensitive than

  18. Distinctive renal cell tumor simulating atrophic kidney with 2 types of microcalcifications. Report of 3 cases.

    Science.gov (United States)

    Hes, Ondrej; de Souza, Tulio Geraldo; Pivovarcikova, Kristyna; Grossmann, Petr; Martinek, Petr; Kuroda, Naoto; Kacerovska, Denisa; Svajdler, Marian; Straka, Lubomir; Petersson, Fredrik; Hora, Milan; Michal, Michal

    2014-04-01

    We report 3 cases of primary renal cell tumor simulating atrophic kidney with distinct gross, morphologic, immunohistochemical, and molecular genetic features. The tumors were retrieved out of more than 17 000 renal tumors from the Plzen Tumor Registry. Tissues for light microscopy had been fixed, embedded, and stained with hematoxylin and eosin using routine procedures. The tumors were further analyzed using immunohistochemistry, array comparative genomic hybridization, and human androgen receptor. Analyses of VHL gene and loss of heterozygosity (LOH) 3p were also performed. The patients were 2 women and 1 man, with ages ranging from 29 to 35 years (mean, 31.3 years). Grossly, the neoplasms were encapsulated and round with largest diameter of 3.5 cm (mean, 3.2 cm). Follow-up available for all patients ranged from 2 to 14 years (mean, 8 years). No aggressive behavior was noted. Histologically, akin to atrophic (postpyelonephritic) kidney parenchyma, the tumors were composed of follicles of varying sizes that were filled by eosinophilic secretion. Rare areas contained collapsed follicles. Each follicle was endowed with a small capillary. The stroma was loose, inconspicuous, and focally fibrotic. Two types of calcifications were noted: typical psammoma bodies and amorphous dark-blue stained calcified deposits. Immunohistochemically, tumors were strongly positive for cytokeratins (OSCAR), CD10, and vimentin, with weak immunopositivity for CAM5.2 and AE1-AE3. WT1 and cathepsin K were weakly to moderately focally to diffusely positive. Tumors were negative for cytokeratin 20, carbonic anhydrase IX, parvalbumin, HMB45, TTF1, TFE3, chromogranin A, thyroglobulin, PAX8, and ALK. Only 1 case was suitable for molecular genetic analyses. No mutations were found in the VHL gene; no methylation of VHL promoter was noted. No numerical aberrations were found by array comparative genomic hybridization analysis. LOH for chromosome 3p was not detected. Analysis of clonality (human

  19. Helicobacter pylori heterogeneity in patients with gastritis and peptic ulcer disease.

    Science.gov (United States)

    Armitano, Rita Inés; Matteo, Mario José; Goldman, Cinthia; Wonaga, Andrés; Viola, Luis Alberto; De Palma, Gerardo Zerbetto; Catalano, Mariana

    2013-06-01

    Genetic diversification allows Helicobacter pylori to persist during chronic colonization/infection. We investigated the intra-host variation of several markers that suggested microevolution in patients with chonic gastritis (CG) and peptic ulcer disease (PUD). One-hundred twenty-six isolates recovered from 14 patients with CG and 13 patients with PUD were analysed. cag pathogenicity island (cagPAI), oipA, vacA, bab gene status and the presence of jhp0926, jhp0945, jhp0947, jhp0949 and jhp0940 genes from the genomic Plasticity Zone (PZ) were taken into accout to investigate intra-host variation. lspA-glmM-RFLP was performed to identify mixed infections. Only one patient was colonised/infected by two ancestrally unrelated strains. Among the 126 isolates, a significant association among cagPAI genotypes, oipA status and vacA alleles was indicated. Complete cagPAI, oipA "on", and vacA s1-m1 variants were significantly found in patients with PUD, without intra-host variations. Isolates from 7/14 patients with CG lacked babA in all chromosomal loci. In contrast, isolates from all or several biopsies of PUD patients carried babA, but in one patient only, the isolates showed positive Lewis b (Leb) binding assay. Considering cagPAI, vacA, oipA, bab genotypes, intra-host variation was also significantly higher in patients with CG. Conversely, a similarly high intra-host variation in almost PZ genes was observed in isolates from patients with CG and PUD. In conclusion, the lowest intra-host variation in cagPAI, oipA, vacA, and bab genes found in patients with PUD suggests the selection of a particular variant along the bacteria-host environment interplay during ulceration development. However, the predominance of this variant may be a refletion of the multifactorial etiology of the disease rather than the cause, as it was also found in patients with CG. The intra-host variation in PZ genes may predict that this genomic region and the other markers of microevolution studied

  20. Helicobacter pylori heterogeneity in patients with gastritis and peptic ulcer disease.

    Science.gov (United States)

    Armitano, Rita Inés; Matteo, Mario José; Goldman, Cinthia; Wonaga, Andrés; Viola, Luis Alberto; De Palma, Gerardo Zerbetto; Catalano, Mariana

    2013-06-01

    Genetic diversification allows Helicobacter pylori to persist during chronic colonization/infection. We investigated the intra-host variation of several markers that suggested microevolution in patients with chonic gastritis (CG) and peptic ulcer disease (PUD). One-hundred twenty-six isolates recovered from 14 patients with CG and 13 patients with PUD were analysed. cag pathogenicity island (cagPAI), oipA, vacA, bab gene status and the presence of jhp0926, jhp0945, jhp0947, jhp0949 and jhp0940 genes from the genomic Plasticity Zone (PZ) were taken into accout to investigate intra-host variation. lspA-glmM-RFLP was performed to identify mixed infections. Only one patient was colonised/infected by two ancestrally unrelated strains. Among the 126 isolates, a significant association among cagPAI genotypes, oipA status and vacA alleles was indicated. Complete cagPAI, oipA "on", and vacA s1-m1 variants were significantly found in patients with PUD, without intra-host variations. Isolates from 7/14 patients with CG lacked babA in all chromosomal loci. In contrast, isolates from all or several biopsies of PUD patients carried babA, but in one patient only, the isolates showed positive Lewis b (Leb) binding assay. Considering cagPAI, vacA, oipA, bab genotypes, intra-host variation was also significantly higher in patients with CG. Conversely, a similarly high intra-host variation in almost PZ genes was observed in isolates from patients with CG and PUD. In conclusion, the lowest intra-host variation in cagPAI, oipA, vacA, and bab genes found in patients with PUD suggests the selection of a particular variant along the bacteria-host environment interplay during ulceration development. However, the predominance of this variant may be a refletion of the multifactorial etiology of the disease rather than the cause, as it was also found in patients with CG. The intra-host variation in PZ genes may predict that this genomic region and the other markers of microevolution studied

  1. Collagenous gastroduodenitis coexisting repeated Dieulafoy ulcer: A case report and review of collagenous gastritis and gastroduodenitis without colonic involvement.

    Science.gov (United States)

    Soeda, Atsuko; Mamiya, Takashi; Hiroshima, Yoshinori; Sugiyama, Hiroaki; Shidara, Sayoko; Dai, Yuichi; Nakahara, Akira; Ikezawa, Kazuto

    2014-10-01

    Collagenous gastritis (CG) is a rare disorder characterized by the thick collagenous subepithelial bands associated with mucosal inflammation. There have been approximately fifty reports in the literature since it was first described in 1989. According to previous reports, CG is heterogeneous and classified into two groups-(1) cases limited to the gastric mucosa in children or young adults, and (2) CG associated with collagenous colitis in elderly adults presenting with chronic watery diarrhea. In Japan, only nine previous cases were reported, and all of them were young adults. We report a case of CG with collagenous duodenitis in a 22-year-old female. She had repeated upper gastrointestinal bleeding from a Dieulafoy lesion of the fornix, but had no symptoms of malabsorption or diarrhea. Endoscopic findings revealed striking nodularity with a smooth islet-shaped normal area in the antrum and the body. The pathological findings of nodular mucosa showed the deposition of collagen bands just under the mucoepithelial lesion. In addition, she had collagenous duodenitis in part of the bulbs, and a colonoscopy showed no abnormalities. We provide a literature review of CG and collagenous gastroduodenitis without colonic involvement. PMID:26184019

  2. Metachronous gastric cancer after successful Helicobacter pylori eradication

    OpenAIRE

    Shiotani, Akiko; Haruma, Ken; David Y Graham

    2014-01-01

    The high incidence of gastric cancer in Japan initially resulted in establishment of a country-wide gastric cancer screening program to detect early and treatable cancers. In 2013 countrywide Helicobacter pylori (H. pylori) eradication was approved coupled with endoscopy to assess for the presence of chronic gastritis. Current data support the notion that cure of the infection in those with non-atrophic gastritis will prevent development of gastric cancer. However, while progression to more s...

  3. Restoration of an atrophic eye socket with custom made eye prosthesis, utilizing digital photography

    Directory of Open Access Journals (Sweden)

    Gaurav P Jayaswal

    2011-01-01

    Full Text Available Ocular defects may cause several ocular and orbital disorders, which require surgical intervention. These defects are psychologically disturbing for the patients, and therefore, they require immediate management and rehabilitation by a team of specialist. Ocular prosthesis may be either readymade (stock or custom made. Fabrication of a custom ocular prosthesis allows for a range of variations during construction. The iris can also be custom made by ocular painting or by digital photography. The optimum cosmetic and functional results of a custom-made prosthesis enhance the patient′s rehabilitation to a normal life style. This paper elaborates the technique for fabrication of a custom-made ocular prosthesis for an atrophic eye socket utilizing digital photography.

  4. Concordancia endoscópico-histológica de la gastritis crónica en Cali

    OpenAIRE

    Gustavo Mariño; Eduardo Lima; Fernado Tuffi García; Carlos Cuello; Harold Cuello; Alberto Alzate

    2009-01-01

    Se realizó un estudio prospectivo con el fin de evaluar la concordancia entre signos endoscópicos y diagnóstico histológico en 216 pacientes con gastritis y metaplasia intestinal. Se estableció un registro codificado de los signos sugestivos de gastritis, que se correlacionaron con los diagnósticos histológicos de las biopsias gástricas. Se seleccionaron aquellas asociaciones que tuvieran una correlación mayor que la esperada por azar. Estas fueron: gastritis atrófica y aumento de visibilidad...

  5. Mesenchymal stem cell implantation in atrophic nonunion of the long bones

    Science.gov (United States)

    Phedy, P.; Kholinne, E.; Djaja, Y. P.; Kusnadi, Y.; Merlina, M.; Yulisa, N. D.

    2016-01-01

    Objectives To explore the therapeutic potential of combining bone marrow-derived mesenchymal stem cells (BM-MSCs) and hydroxyapatite (HA) granules to treat nonunion of the long bone. Methods Ten patients with an atrophic nonunion of a long bone fracture were selectively divided into two groups. Five subjects in the treatment group were treated with the combination of 15 million autologous BM-MSCs, 5g/cm3 (HA) granules and internal fixation. Control subjects were treated with iliac crest autograft, 5g/cm3 HA granules and internal fixation. The outcomes measured were post-operative pain (visual analogue scale), level of functionality (LEFS and DASH), and radiograph assessment. Results Post-operative pain evaluation showed no significant differences between the two groups. The treatment group demonstrated faster initial radiographic and functional improvements. Statistically significant differences in functional scores were present during the first (p = 0.002), second (p = 0.005) and third (p = 0.01) month. Both groups achieved similar outcomes by the end of one-year follow-up. No immunologic or neoplastic side effects were reported. Conclusions All cases of nonunion of a long bone presented in this study were successfully treated using autologous BM-MSCs. The combination of autologous BM-MSCs and HA granules is a safe method for treating nonunion. Patients treated with BM-MSCs had faster initial radiographic and functional improvements. By the end of 12 months, both groups had similar outcomes. Cite this article: H.D. Ismail, P. Phedy, E. Kholinne, Y. P. Djaja, Y. Kusnadi, M. Merlina, N. D. Yulisa. Mesenchymal stem cell implantation in atrophic nonunion of the long bones: A translational study. Bone Joint Res 2016;5:287–293. DOI: 10.1302/2046-3758.57.2000587. PMID:27412657

  6. Local inhibition of angiogenesis results in an atrophic non-union in a rat osteotomy model

    Directory of Open Access Journals (Sweden)

    M Fassbender

    2011-07-01

    Full Text Available Long bone and in particular tibia fractures frequently fail to heal. A disturbed revascularisation is supposed to be a major cause for impaired bone healing or the development of non-unions. We aim to establish an animal model, which reliably mimics the clinical situation. Human microvascular endothelial cells (HMEC-1 and primary human osteoblast like cells (POBs were cultured with different angiogenesis-inhibitors (Fumagillin, SU5416, Artesunate and 3,5,4’-Trimethoxystilbene released out of poly(D,L-Lactide (PDLLA coated k-wires and cell activity was determined. Discs containing PDLLA or PDLLA + Fumagillin/Artesunate were placed at the chorionallantoic membrane of hen eggs and the effect on vessel formation and egg vitality was observed. Tibia osteotomy was performed in rats and stabilised with K-wires coated with PDLLA + Fumagillin or with PDLLA only (control group. The healing was compared at different time points to the PDLLA control. Fumagillin and Artesunate inhibited the activity of HMEC-1 with minor effect on POBs. Artesunate caused embryonic death, whereas Fumagillin had no effects on egg vitality, but reduced the blood vessels. In the animal study all rats showed an impaired healing with reduced biomechanical stability. The Fumagillin treated tibiae had a significantly decreased callus size at day 42 and 84, less blood vessels in the early callus, a reduced histological callus size at day 10, 28 and 84, as well as an altered callus composition. This study presents a less vascularised, atrophic, tibia non-union and can be used in further investigations to analyse the pathology of atrophic non-union and to test new interventions.

  7. A comparative study of vaginal estrogen cream and sustained-release estradiol vaginal tablet (Vagifem in the treatment of atrophic vaginitis in Isfahan, Iran in 2010-2012

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    Pardis Hosseinzadeh

    2015-01-01

    Full Text Available Background: Atrophic vaginitis is a disease, which affects up to 50% of postmenopausal women. This study compared the effectiveness and user-friendliness of Vagifem (an estradiol vaginal tablet and vaginal estrogen cream in the treatment of atrophic vaginitis. Materials and Methods: One hundred and sixty postmenopausal women with symptoms of atrophic vaginitis were randomly divided into two groups of treatment with Vagifem or with vaginal estrogen cream for 12 weeks. Patients used the medication daily for the first 2 weeks of the study, and twice weekly. Severity of vaginal atrophy and four main symptoms of atrophic vaginitis including dysuria, dyspareunia, vaginal itching, and dryness were evaluated and compared before and after treatment. In addition, patients were asked regarding user-friendliness and hygienic issues of medications. Results: Both vaginal estrogen cream and Vagifem significantly improved symptoms of atrophic vaginitis but in terms of effectiveness for the treatment symptoms of atrophic vaginitis, there was no significant difference between the two medications. Vagifem compared to estrogen cream resulted in significantly lower rate of hygienic problems (0% versus 23%, P < 0.001, and was reported by the patients as a significantly easier method of treatment (90% versus 55%, P < 0.0001. Conclusion: This investigation showed that Vagifem is an appropriate medication for the treatment of atrophic vaginitis, which is as effective as vaginal estrogen creams and is more user-friendly.

  8. Medication Treatment Efficacy and Chronic Orofacial Pain.

    Science.gov (United States)

    Clark, Glenn T; Padilla, Mariela; Dionne, Raymond

    2016-08-01

    Chronic pain in the orofacial region has always been a vexing problem for dentists to diagnose and treat effectively. For trigeminal neuropathic pain, there are 3 medications (gabapentinoids, tricyclic antidepressants, and serotonin-norepinephrine reuptake inhibitors) to use plus topical anesthetics that have therapeutic efficacy. For chronic daily headaches (often migraine in origin), 3 prophylactic medications have reasonable therapeutic efficacy (β-blockers, tricyclic antidepressants, and antiepileptic drugs). The 3 Food and Drug Administration-approved drugs for fibromyalgia (pregabalin, duloxetine, and milnacipran) are not robust, with poor efficacy. For osteroarthritis, nonsteroidal anti-inflammatory drugs have therapeutic efficacy and when gastritis contraindicates them, corticosteriod injections are helpful. PMID:27475515

  9. A comparative study of single use and combined use of lansoprazole, deanxit in treating erosive gastritis complicated with negative emotions

    Institute of Scientific and Technical Information of China (English)

    龚家顺

    2014-01-01

    Objective To study the effect of single use and combined use of lansoprazole,deanxit in treating erosive gastritis complicated with negative emotions.Methods Erosive gastritis patients complicated with negative emotions in our hospital from January,2011—December,2012were enrolled and randomly divided into observation group and control group.Observation group was given deanxit 1 tablet every time,2 times every day and lansoprazole 15 mg every time,2 times every day;control

  10. An unusual case of collagenous gastritis in a middle- aged woman with systemic lupus erythromatosis: a case report

    OpenAIRE

    Al-Kandari, Asma; Al-Alardati, Hossam; Sayadi, Hassan; Al-Judaibi, Bandar; Mawardi, Mohammad

    2014-01-01

    Introduction Collagenous gastritis is a rare histopathologic disease. It is characterized by marked subepithelial collagen deposition with associated inflammatory infiltrate. It is considered an uncommon disease among the general population. Collagenous gastritis without colonic involvement is an extremely rare disease. It is not known to be associated with systemic lupus erythromatosis. This is the first report of this type of association. Case presentation We present a 47-year-old woman fro...

  11. Histopathologic Characterization of Acute Gastritis and Duodenitis Induced by Inoculation of Escherichia coli O157 in Mice

    OpenAIRE

    Horii, Toshinobu; KOBAYASHI, Miya

    2011-01-01

    Objective: To examine the effect of intragastric inoculation of an Escherichia coli O157 strain, which does not have such pathogenic factors as the stx, eae and EHEC-hlyA genes, on the induction of acute gastritis and duodenitis in BALB/c mice. Design: Time-dependent histopathologic changes were characterized in stomach and duodenum mucoepithelium by light and transmission electron microscopy. Results: The acute gastritis was characterized by inflammation and polymorphonuclear leukocyte infil...

  12. Concordancia endoscópico-histológica de la gastritis crónica en Cali

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    Gustavo Mariño

    2009-10-01

    Full Text Available Se realizó un estudio prospectivo con el fin de evaluar la concordancia entre signos endoscópicos y diagnóstico histológico en 216 pacientes con gastritis y metaplasia intestinal. Se estableció un registro codificado de los signos sugestivos de gastritis, que se correlacionaron con los diagnósticos histológicos de las biopsias gástricas. Se seleccionaron aquellas asociaciones que tuvieran una correlación mayor que la esperada por azar. Estas fueron: gastritis atrófica y aumento de visibilidad de vasos en antro, Kappa 0.208 (0.041-0.376; gastritis atrófica y aumento de visibilidad de vasos en cuerpo gástrico, Kappa 0.195 (0.002-0.388; gastritis atrófica y superficie en empedrado en antro, Kappa 0.213 (0.044-0.381; inflamación aguda y pliegues engrosados en antro, Kappa 0.094 (0.018-0.16. Hubo una concordancia pobre entre la mayoría de los signos endoscópicos y los diagnósticos histológicos. El diagnóstico definitivo de la gastritis sólo se debe hacer con base en los estudios histológicos de las biopsias.

  13. Fatal Clostridium perfringens sepsis due to emphysematous gastritis and literature review.

    Science.gov (United States)

    Sarvari, Karoly Peter; Vasas, Bela; Kiss, Ildiko; Lazar, Andrea; Horvath, Istvan; Simon, Marianna; Peto, Zoltan; Urban, Edit

    2016-08-01

    A 76-year-old female patient was admitted to the Level I Emergency Department of University of Szeged with severe abdominal pain and vomiting. The clinical assessment with laboratory tests and radiological investigations confirmed severe sepsis associated with intravascular hemolysis and multiorgan failure and acute pancreatitis. On the abdominal CT, besides of other abnormalities, the presence of gas bubbles in the stomach, small intestines and liver were seen. The gastric alterations pointed to emphysematous gastritis. Despite of the medical treatment, the patient's condition quickly deteriorated and eight hours after admission the patient died. The autopsy evaluation revealed systemic infection of abdominal origin caused by gas-producing Gram-positive bacteria, and the post-mortem microbiological cultures confirmed the presence of Cloctridium perfringens in many abdominal organs. Emphysematous gastritis seemed to be the primary infectious focus. PMID:27036998

  14. Campylobacter pylori, the spiral bacterium associated with human gastritis, is not a true Campylobacter sp.

    OpenAIRE

    Romaniuk, P J; Zoltowska, B; Trust, T J; Lane, D J; Olsen, G.J.; Pace, N R; Stahl, D A

    1987-01-01

    Comparison of partial 16S rRNA sequences from representative Campylobacter species indicates that the Campylobacter species form a previously undescribed basic eubacterial group, which is related to the other major groups only by very deep branching. This analysis was extended to include the spiral bacterium associated with human gastritis, Campylobacter pylori (formerly Campylobacter pyloridis). The distance between C. pylori and the other Campylobacter species is sufficient to exclude the p...

  15. Collagenous gastritis and collagenous colitis: a report with sequential histological and ultrastructural findings

    OpenAIRE

    Pulimood, A; B Ramakrishna; Mathan, M

    1999-01-01

    The case is reported of a young adult man with collagenous gastritis, an extremely rare disorder with only three case reports in the English literature, who subsequently presented with collagenous colitis. Sequential gastric biopsies showed a notable increase in thickness of the subepithelial collagen band. Ultrastructural study of gastric and rectal mucosa showed the characteristic subepithelial band composed of haphazardly arranged collagen fibres, prominent degranulating eosinophils, and a...

  16. Collagenous gastritis and collagenous colitis: a report with sequential histological and ultrastructural findings.

    Science.gov (United States)

    Pulimood, A B; Ramakrishna, B S; Mathan, M M

    1999-06-01

    The case is reported of a young adult man with collagenous gastritis, an extremely rare disorder with only three case reports in the English literature, who subsequently presented with collagenous colitis. Sequential gastric biopsies showed a notable increase in thickness of the subepithelial collagen band. Ultrastructural study of gastric and rectal mucosa showed the characteristic subepithelial band composed of haphazardly arranged collagen fibres, prominent degranulating eosinophils, and activated pericryptal fibroblasts. PMID:10323893

  17. Clinical outcome of pediatric collagenous gastritis: Case series and review of literature

    OpenAIRE

    Hijaz, Nadia Mazen; Septer, Seth Steven; DeGaetano, James; Attard, Thomas Mario

    2013-01-01

    Collagenous gastritis (CG) is characterized by patchy subepithelial collagen bands. Effective treatment and the clinical and histological outcome of CG in children are poorly defined. The aim of this study is to summarize the published literature on the clinical outcome and response to therapy of pediatric CG including two new cases. We performed a search in Pubmed, OVID for related terms; articles including management and clinical and/or endo-histologic follow up information were included an...

  18. Gastritis caused by ingestion of eggs of puffer fish : a case report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Dong Ho; Ko, Young Tae [Kyunghee Univ. College of Medicine, Seoul (Korea, Republic of)

    1996-09-01

    Tetrodotoxin is a neurotoxin, so gastrointestinal symptoms are very rare; these described in the literature are merely nausea and vomiting. Severe complications in the gastrointestinal tract caused by tetrodotoxin have not been radiologically reported. US and CT show thickening of the gastric wall and contraction of the lumen, and upper gastrointestinal series show shortening, lobulation and irregularity of the lesser and greater curvature of the body and antrum similar to the findings of corrosive gastritis.

  19. A survey on Candida colonization prevalence in patients with gastritis, duodenitis and peptic ulcer

    OpenAIRE

    Hashemi, S.J.; Kordbacheh, P.; Malekzadeh, R.; M Mehrabani

    2006-01-01

    Background: Prolonged antiacid and antibiotic usage in gasterointestinal diseases may predispose candidial colonization in GI tract. In order to isolate and diagnose of candida infections in patients with gastritis, duodenitis, gastric ulcer and duodenal ulcer, this study have been planned. Methods: We studied 300 biopsy specimens of patients referred to hospital, 51.7% of the patients were male and the others were female. The isolated fungi were identified by direct examination and culture o...

  20. Co-existence of Sarcina Organisms and Helicobacter pylori Gastritis/Duodenitis in Pediatric Siblings

    OpenAIRE

    Sauter, Jennifer L.; Nayar, Suresh K.; Anders, Paige D.; D’Amico, Michael; Butnor, Kelly J.; Wilcox, Rebecca L.

    2013-01-01

    Sarcina are gram-positive anaerobic bacteria found to be associated with delayed gastric emptying and gastric outlet obstruction. We describe two cases of Sarcina co-existing with Helicobacter pylori organisms in pediatric siblings presenting within four months of each other with pyloric obstruction secondary to severe gastritis/duodenitis. The co-existence of Sarcina and Helicobacter pylori has not, to our knowledge, been previously reported. Its characteristic tetrad packeted morphology per...

  1. Clinical and Histological Results of Vertical Ridge Augmentation of Atrophic Posterior Mandible with Inlay Technique of Cancellous Equine Bone Blocks

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    Pistilli R

    2013-12-01

    Full Text Available Aim: We want to evaluate a new bone block material in the inlay technique, for the vertical bone augmentation of a posterior atrophic mandible, in order to perfom aesthetic and prosthetic rehabilitation and enable implant insertion. Materials & Methods: Inlay technique and the subsequent successful implant rehabilitation in the atrophic right posterior mandible in a 42-year-old woman, was completed using a cancellous equine bone block as grafting material. Results: Three months after surgical procedure both clinical and histological aspects show complete integration of the biomaterial with the surrounding bone and three dental implants were placed. Computed tomography and conventional radiography showed a 5mm mean vertical bone gain. Conclusion: Cancellous equine bone grafts may be an effective alternative to autogenous bone and/or inorganic bovine bone for reconstruction of the posterior mandible using inlay technique.

  2. Observation of Pain-Sensitive Points along the Meridians in Patients with Gastric Ulcer or Gastritis

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    Hui Ben

    2012-01-01

    Full Text Available This study aims to investigate the sensitization of human skin points along certain meridians related to visceral disease by using the pressure-pain threshold (PPT as an indicator. We detected and compared the PPTs of people with and without gastric ulcer or gastritis on the related acupoints, abdomen area, and back area with von Frey detector and observed the similarities and differences under their respective physiological and pathological states. The results showed that (1 the PPTs of patients with gastric ulcer on related acupoints decreased significantly compared with the control group; (2 there was no significant difference in PPT between the chosen points of the measured meridian and the adjacent nonacupoints; (3 there was an apparent distribution of tender points on the relevant abdomen and back regions of patients with gastric ulcer or gastritis, but none was found on the control group; (4 the pain-sensitive points of gastric ulcer and gastritis patients were BURONG (ST19, LIANGMEN (ST21, and HUAROUMEN (ST24 of the stomach meridian on the abdominal region and PISHU (BL20, WEISHU (BL21, and WEICANG (BL50 on the back, among others The results suggest that the practical significance of acupoints may lie in its role as a relatively sensitive functional area. In a pathological state, the reflex points on the skin which are related to certain visceral organs become sensitive and functionally intensify.

  3. Expression of matrix metalloproteinases 2 and 9 in human gastric cancer and superficial gastritis

    Science.gov (United States)

    Sampieri, Clara Luz; de la Peña, Sol; Ochoa-Lara, Mariana; Zenteno-Cuevas, Roberto; León-Córdoba, Kenneth

    2010-01-01

    AIM: To assess expression of matrix metalloproteinases 2 (MMP2) and MMP9 in gastric cancer, superficial gastritis and normal mucosa, and to measure metalloproteinase activity. METHODS: MMP2 and MMP9 mRNA expression was determined by quantitative real-time polymerase chain reaction. Normalization was carried out using three different factors. Proteins were analyzed by quantitative gelatin zymography (qGZ). RESULTS: 18S ribosomal RNA (18SRNA) was very highly expressed, while hypoxanthine ribosyltransferase-1 (HPRT-1) was moderately expressed. MMP2 was highly expressed, while MMP9 was not detected or lowly expressed in normal tissues, moderately or highly expressed in gastritis and highly expressed in cancer. Relative expression of 18SRNA and HPRT-1 showed no significant differences. Significant differences in MMP2 and MMP9 were found between cancer and normal tissue, but not between gastritis and normal tissue. Absolute quantification of MMP9 echoed this pattern, but differential expression of MMP2 proved conflictive. Analysis by qGZ indicated significant differences between cancer and normal tissue in MMP-2, total MMP-9, 250 and 110 kDa bands. CONCLUSION: MMP9 expression is enhanced in gastric cancer compared to normal mucosa; interpretation of differential expression of MMP2 is difficult to establish. PMID:20333791

  4. Helicobacter-pylori Negative Gastritis in Children—A New Clinical Enigma

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    Yoram Elitsur

    2014-10-01

    Full Text Available The decrease in the prevalence of Helicobacter pylori (Hp infection in children in the world gave rise to a new pathological finding termed as Hp-negative gastritis. Unfortunately, the term “Hp-negative gastritis” has not been identified as a pathological process and has the status of a “second cousin”; in most publications it was never mentioned as a subject to be dealt with, but was “left over” data that was never the topic of the manuscripts’ discussions. Only recently has the topic captured the attention of the pathologists who described this phenomenon in adults, yet the pathological and/or clinical spectrum or significance of this phenomenon has not been adequately investigated. In the current manuscript we describe Hp-negative gastritis in children, summarize its clinical prevalence and touch upon the possible etiology, pathology, and/or therapeutic implication. Overall, this review has concluded that Hp-negative gastritis is a pathological phenomenon in children that needs further investigation, and to date, as the title suggests, is a new clinical enigma that needs to be considered.

  5. Changes of alkB Gene Expression in Gastric Cancer and Atrophic Gastritis%alkB基因在胃癌和萎缩性胃炎黏膜组织中的表达改变

    Institute of Scientific and Technical Information of China (English)

    陈胜良; 李雷佳; 童菊芳; 房静远; 萧树东

    2007-01-01

    背景:DNA或RNA分子异常甲基化导致的抑癌基因沉默、突变或其他功能性障碍是胃癌发生的关键机制之一.最近研究发现alkB基因产物具有修复DNA和mRNA碱基异常甲基化、纠正基因突变、复制转录障碍等功能,但对其在胃癌及其癌前病变组织中的表达情况尚不了解.目的:探讨alkB基因在胃癌及其癌前病变组织中的表达改变.方法:收集11例胃癌、癌旁和远离癌灶正常黏膜组织以及107例慢性萎缩性胃炎和121例非萎缩性胃炎患者的内镜活检黏膜,应用基因表达谱芯片实验评估alkB基因在各组织中的表达.以逆转录聚合酶链反应(RT-PCR)检验上述结果.结果:与远离癌灶正常黏膜组织相比,alkB基因在胃癌中的表达降低(Ratio值为0.208);与非萎缩性胃炎黏膜组织相比,alkB基因在萎缩性胃炎黏膜组织中的表达降低(Ratio值为0.378);而alkB基因在癌旁和远离癌灶正常黏膜组织中的表达无显著差异(Ratto值为0.726).结论:alkB基因在胃癌和萎缩性胃炎黏膜组织中的表达下调,可能参与了胃癌发生过程中基因甲基化紊乱的机制.alkB基因是有潜在研究价值的分子靶标.

  6. Predictability of short implants (< 10 mm) as a treatment option for the rehabilitation of atrophic maxillae. A systematic review

    OpenAIRE

    Sierra-Sánchez, José-Luis; García-Sala-Bonmatí, Fernando; Martínez-González, Amparo; García-Dalmau, Carlos; Mañes-Ferrer, José-Félix; Brotons-Oliver, Alejandro

    2016-01-01

    Background Short implants (< 10 mm) are one of the treatment options available in cases of limited vertical bone. A purpose of this paper is to evaluate the predictability of short implants as an alternative to technically molthough such implants are now widely used, there is controversy regarding their clinical reliability. There complex treatments in patients with atrophic maxillae, based on a systematic review of the literature and the analysis of the implant survival rates, changes in per...

  7. The FSHD atrophic myotube phenotype is caused by DUX4 expression.

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    Céline Vanderplanck

    Full Text Available BACKGROUND: Facioscapulohumeral muscular dystrophy (FSHD is linked to deletions in 4q35 within the D4Z4 repeat array in which we identified the double homeobox 4 (DUX4 gene. We found stable DUX4 mRNAs only derived from the most distal D4Z4 unit and unexpectedly extended to the flanking pLAM region that provided an intron and a polyadenylation signal. DUX4 encodes a transcription factor expressed in FSHD but not control primary myoblasts or muscle biopsies. The DUX4 protein initiates a large transcription deregulation cascade leading to muscle atrophy and oxidative stress, which are FSHD key features. METHODOLOGY/PRINCIPAL FINDINGS: We now show that transfection of myoblasts with a DUX4 expression vector leads to atrophic myotube formation associated with the induction of E3 ubiquitin ligases (MuRF1 and Atrogin1/MAFbx typical of muscle atrophy. DUX4 induces expression of downstream targets deregulated in FSHD such as mu-crystallin and TP53. We developed specific siRNAs and antisense oligonucleotides (AOs targeting the DUX4 mRNA. Addition of these antisense agents to primary FSHD myoblast cultures suppressed DUX4 protein expression and affected expression of the above-mentioned markers. CONCLUSIONS/SIGNIFICANCE: These results constitute a proof of concept for the development of therapeutic approaches for FSHD targeting DUX4 expression.

  8. Effects of low dose estrogen therapy on the vaginal microbiomes of women with atrophic vaginitis.

    Science.gov (United States)

    Shen, Jian; Song, Ning; Williams, Christopher J; Brown, Celeste J; Yan, Zheng; Xu, Chen; Forney, Larry J

    2016-01-01

    Atrophic vaginitis (AV) is common in postmenopausal women, but its causes are not well understood. The symptoms, which include vaginal itching, burning, dryness, irritation, and dyspareunia, can usually be alleviated by low doses of estrogen given orally or locally. Regrettably, the composition of vaginal bacterial communities in women with AV have not been fully characterized and little is known as to how these communities change over time in response to hormonal therapy. In the present intervention study we determined the response of vaginal bacterial communities in postmenopausal women with AV to low-dose estrogen therapy. The changes in community composition in response to hormonal therapy were rapid and typified by significant increases in the relative abundance of Lactobacillus spp. that were mirrored by a decreased relative abundance of Gardnerella. These changes were paralleled by a significant four-fold increase in serum estradiol levels and decreased vaginal pH, as well as nearly a two-fold increase in the Vaginal Maturation Index (VMI). The results suggest that after menopause a vaginal microbiota dominated by species of Lactobacillus may have a beneficial role in the maintenance of health and these findings that could lead to new strategies to protect postmenopausal women from AV. PMID:27103314

  9. Impaired translocation of GLUT4 results in insulin resistance of atrophic soleus muscle.

    Science.gov (United States)

    Xu, Peng-Tao; Song, Zhen; Zhang, Wen-Cheng; Jiao, Bo; Yu, Zhi-Bin

    2015-01-01

    Whether or not the atrophic skeletal muscle induces insulin resistance and its mechanisms are not resolved now. The antigravity soleus muscle showed a progressive atrophy in 1-week, 2-week, and 4-week tail-suspended rats. Hyperinsulinemic-euglycemic clamp showed that the steady-state glucose infusion rate was lower in 4-week tail-suspended rats than that in the control rats. The glucose uptake rates under insulin- or contraction-stimulation were significantly decreased in 4-week unloaded soleus muscle. The key protein expressions of IRS-1, PI3K, and Akt on the insulin-dependent pathway and of AMPK, ERK, and p38 on the insulin-independent pathway were unchanged in unloaded soleus muscle. The unchanged phosphorylation of Akt and p38 suggested that the activity of two signal pathways was not altered in unloaded soleus muscle. The AS160 and GLUT4 expression on the common downstream pathway also was not changed in unloaded soleus muscle. But the GLUT4 translocation to sarcolemma was inhibited during insulin stimulation in unloaded soleus muscle. The above results suggest that hindlimb unloading in tail-suspended rat induces atrophy in antigravity soleus muscle. The impaired GLUT4 translocation to sarcolemma under insulin stimulation may mediate insulin resistance in unloaded soleus muscle and further affect the insulin sensitivity of whole body in tail-suspended rats.

  10. Impaired Translocation of GLUT4 Results in Insulin Resistance of Atrophic Soleus Muscle

    Directory of Open Access Journals (Sweden)

    Peng-Tao Xu

    2015-01-01

    Full Text Available Whether or not the atrophic skeletal muscle induces insulin resistance and its mechanisms are not resolved now. The antigravity soleus muscle showed a progressive atrophy in 1-week, 2-week, and 4-week tail-suspended rats. Hyperinsulinemic-euglycemic clamp showed that the steady-state glucose infusion rate was lower in 4-week tail-suspended rats than that in the control rats. The glucose uptake rates under insulin- or contraction-stimulation were significantly decreased in 4-week unloaded soleus muscle. The key protein expressions of IRS-1, PI3K, and Akt on the insulin-dependent pathway and of AMPK, ERK, and p38 on the insulin-independent pathway were unchanged in unloaded soleus muscle. The unchanged phosphorylation of Akt and p38 suggested that the activity of two signal pathways was not altered in unloaded soleus muscle. The AS160 and GLUT4 expression on the common downstream pathway also was not changed in unloaded soleus muscle. But the GLUT4 translocation to sarcolemma was inhibited during insulin stimulation in unloaded soleus muscle. The above results suggest that hindlimb unloading in tail-suspended rat induces atrophy in antigravity soleus muscle. The impaired GLUT4 translocation to sarcolemma under insulin stimulation may mediate insulin resistance in unloaded soleus muscle and further affect the insulin sensitivity of whole body in tail-suspended rats.

  11. Prosthetic management of the atrophic mandible using endosseous implants and overdentures: a six year review.

    Science.gov (United States)

    Chan, M F; Johnston, C; Howell, R A; Cawood, J I

    1995-11-11

    This paper presents the treatment results and experiences gained from a retrospective study of patients treated with the IMZ osseo-integrated implant system and mandibular overdentures. Patients experiencing problems wearing conventional dentures were assessed by the implant team and 65 cases were treated with 154 endosseous implants placed in the edentulous mandible. Two to four implants were placed in each case and in addition some patients have had augmentation of the mandible with hydroxyapatite. The definitive mandibular prostheses were supported by both implants and the residual ridges. A variety of retention systems were utilised, which included different types of bar and clip, stud attachments, and magnets. The patients have been followed up regularly and evaluated after periods of between one and six years. Six implants have failed over this time resulting in a success rate of over 96%. Most patients expressed a high degree of satisfaction with their new overdentures. There was, however, a considerable burden of maintenance care required for the patient group examined. The findings demonstrate that implant retained overdentures offer a highly effective means of oral rehabilitation for the atrophic mandible, restoring both oral function and facial form. PMID:7495628

  12. Effects of low dose estrogen therapy on the vaginal microbiomes of women with atrophic vaginitis.

    Science.gov (United States)

    Shen, Jian; Song, Ning; Williams, Christopher J; Brown, Celeste J; Yan, Zheng; Xu, Chen; Forney, Larry J

    2016-01-01

    Atrophic vaginitis (AV) is common in postmenopausal women, but its causes are not well understood. The symptoms, which include vaginal itching, burning, dryness, irritation, and dyspareunia, can usually be alleviated by low doses of estrogen given orally or locally. Regrettably, the composition of vaginal bacterial communities in women with AV have not been fully characterized and little is known as to how these communities change over time in response to hormonal therapy. In the present intervention study we determined the response of vaginal bacterial communities in postmenopausal women with AV to low-dose estrogen therapy. The changes in community composition in response to hormonal therapy were rapid and typified by significant increases in the relative abundance of Lactobacillus spp. that were mirrored by a decreased relative abundance of Gardnerella. These changes were paralleled by a significant four-fold increase in serum estradiol levels and decreased vaginal pH, as well as nearly a two-fold increase in the Vaginal Maturation Index (VMI). The results suggest that after menopause a vaginal microbiota dominated by species of Lactobacillus may have a beneficial role in the maintenance of health and these findings that could lead to new strategies to protect postmenopausal women from AV.

  13. On the Feasibility of Utilizing Allogeneic Bone Blocks for Atrophic Maxillary Augmentation

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    Alberto Monje

    2014-01-01

    Full Text Available Purpose. This systematic review was aimed at assessing the feasibility by means of survival rate, histologic analysis, and causes of failure of allogeneic block grafts for augmenting the atrophic maxilla. Material and Methods. A literature search was conducted by one reviewer in several databases. Articles were included in this systematic review if they were human clinical trials in which outcomes of allogeneic bone block grafts were studied by means of survival rate. In addition other factors were extracted in order to assess their influence upon graft failure. Results. Fifteen articles fulfilled the inclusion criteria and subsequently were analyzed in this systematic review. A total of 361 block grafts could be followed 4 to 9 months after the surgery, of which 9 (2.4% failed within 1 month to 2 months after the surgery. Additionally, a weighed mean 4.79 mm (95% CI: 4.51–5.08 horizontal bone gain was computed from 119 grafted sites in 5 studies. Regarding implant cumulative survival rate, the weighed mean was 96.9% (95% CI: 92.8–98.7%, computed from 228 implants over a mean follow-up period of 23.9 months. Histologic analysis showed that allogeneic block grafts behave differently in the early stages of healing when compared to autogenous block grafts. Conclusion. Atrophied maxillary reconstruction with allogeneic bone block grafts represents a reliable option as shown by low block graft failure rate, minimal resorption, and high implant survival rate.

  14. What is the Optimal Treatment of Atrophic Scaphoid Non-Union?

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    Alper Cirakli

    2014-12-01

    Full Text Available Aim: To evaluate the efficacy of the treatment method of autogenous iliac wing or radius bone graft and fixation with screw applied to cases of scaphoid non-union. Material and Method: A retrospective evaluation was made of 89 cases between 2000 and 2014. Postoperative measurements were taken of both wrists%u2019 movement with a goniometer and muscle strength was assessed with a dynamometer. Fractures were evaluated radiologically according to the Herbert-Fisher System and the functional results according to the Herbert-Fisher Classification System and the Mayo Clinic Modified Wrist Scoring System. The data were input to the SPSS system and evaluated with the Shapiro-Wilk test. Results: Non-union were on the right side in 47 and the left side in 42 cases. The fracture was seen to be in the waist in 60 cases (67.5%, in the proximal third in 27 cases (30.3% and in the distal third in two cases (2.2%. The mean follow-up period was 16.4 months (range, 5-72 months. Definitive findings of union were observed in 71 cases. The mean time to union was 14.9 weeks (range, 8-40 weeks. Discussion: The grafting procedure applied is an invasive technique but if it is considered that there are negative effects of open surgery on the feeding of the scaphoid bone, then in the treatment of scaphoid non-union which is atrophic non-union, ultimately autogenous bone grafting and screw fixation is a safe and successful method and because of the pain created by an iliac wing graft, radius distal bone graft can be considered more appropriate.

  15. Are atrophic long-bone nonunions associated with low-grade infections?

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    Dapunt U

    2015-12-01

    Full Text Available Ulrike Dapunt,1 Ole Spranger,2 Simone Gantz,1 Irene Burckhardt,3 Stefan Zimmermann,3 Gerhard Schmidmaier,2 Arash Moghaddam2 1Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, 2HTRG–Heidelberg Trauma Research Group, Trauma and Reconstructive Surgery, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Heidelberg University Hospital, 3Department for Infectious Diseases, Medical Microbiology and Hygiene, Heidelberg, Germany Abstract: Impaired fracture healing, especially when associated with bacterial infection, is a severe complication following long-bone fractures and requires special treatment. Because standard diagnostic techniques might provide falsely negative results, we evaluated the sonication method for detection of bacteria on implants of patients with fracture nonunions. A total of 49 patients with a nonunion (group NU and, for comparison, 45 patients who had undergone routine removal of osteosynthetic material (group OM, were included in the study. Five different diagnostic methods (culture of tissue samples, culture of intraoperative swabs, histopathology of tissue samples, culture of sonication fluid, and 16S ribosomal DNA polymerase chain reaction of sonication fluid were compared and related to clinical data. Among the diagnostic tests, culture of sonication fluid demonstrated by far the highest detection rate of bacteria (57% in group NU, and rather unexpectedly 40% in group OM. Culture of sonication samples also revealed a broad spectrum of bacteria, in particular Propionibacterium spp. In conclusion, our results indicate that more bacteria can be detected on implants of patients with atrophic nonunions of long-bone fractures by means of the sonication procedure, which provides a valuable additional diagnostic tool to decide on a surgical procedure (eg, two-step procedure and to further specify antimicrobial therapy. Keywords: sonication, osteosynthetic material, osteomyelitis 

  16. Incidencia actual de la gastritis: una breve revisión

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    Julio César Fernández Travieso

    2014-01-01

    Full Text Available Uno de los trastornos que con más frecuencia afecta a la población mundial lo constituyen las enfermedades gastrointestinales, las cuales se encuentran entre las primeras causas de muerte, al estar incluidas entre ellas el cáncer colorectal y el gástrico. Entre las enfermedades gastrointestinales más comunes se encuentra la gastritis, padecimiento de etiología multifactorial que puede originarse por diversas causas, entre las que se incluyen las infecciones por bacterias como Helicobacter pylori, Echericha coli, Salmonella, el consumo de antiinflamatorios no esteroidales, consumo excesivo de alcohol, fumar, comer alimentos picantes o salados, cirugía mayor, lesiones traumáticas o quemaduras, infección grave, anemia perniciosa, enfermedades autoinmunológicas y el reflujo biliar crónico. Su diagnóstico se realiza por medio de la gastroscopia, exámenes de sangre, cultivo de heces y el estudio histopatológico de la biopsia de mucosa gástrica previamente extraída de la exploración endoscópica. En esta revisión se aborda brevemente la gastritis, su clasificación y etiología. Además, se discuten sus factores de riesgo y se enfatiza su control como medida clave en las estrategias de prevención, así como se aborda el adecuado tratamiento farmacológico para su manejo. Se concluye que la mejor manera de reducir la gastritis radica en su prevención, control de los factores de riesgo, estilo de vida saludable y su adecuado manejo terapéutico.

  17. Helicobacter pylori y estrés psicosocial en pacientes con gastritis crónica

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    José I. Montaño

    2006-06-01

    Full Text Available Objetivo: Determinar la prevalencia de Helicobacter pylori y el estrés psicosocial en pacientes con síntomas digestivos recidivantes y diagnóstico previo de gastritis crónica. Métodos: Se realizó un estudio piloto de casos y controles donde el grupo de estudio fueron pacientes con gastritis crónica e infección por H. pylori y el grupo control, enfermos con gastritis crónica sin infección. Los pacientes se evaluaron en el Hospital Universitario del Valle (HUV y en la Fundación Clínica Valle del Lili (FVL en Cali, Colombia durante el 2003. La infección por H. pylori se determinó por endoscopia digestiva y el estrés psicosocial mediante la Escala de Ansiedad y Depresión en el Hospital (HADS. Resultados: Se estudiaron 164 pacientes, 74 (45.1% en el HUV y 90 (54.9% en la FVL. Las características sociodemográficas del grupo en estudio y del control fueron comparables. Se observó infección por H. pylori en 113 (68.9% pacientes y estrés psicosocial en 115 (70.1%. Los niveles de ansiedad fueron mayores que los de depresión (ansiedad mediana=9, rango 1-20; depresión mediana=6, rango 0-17 especialmente en el HUV (p=0.03. El estrés psicosocial no se asociaba con la infección por H. pylori (p=0.69. Conclusión: Los pacientes con diagnóstico endoscópico previo de gastritis crónica y síntomas digestivos recidivantes presentan una alta prevalencia de infección por H. pylori y estrés psicosocial sin estar asociados estos dos factores.

  18. Q-Ulcer: un medicamento para el tratamiento de la gastritis en Pediatría

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    Juan A. Castillo Hernández

    2005-01-01

    Full Text Available El dolor abdominal recurrente afecta aproximadamente al 12 % de la población pediátrica mundial. La endoscopia con biopsia gástrica y prueba de ureasa han sugerido que este dolor se relaciona con gastritis nodular asociada a infección por Helicobacter pylori (Hp. Se realizó un estudio en 66 niños entre 7 y 15 años de edad y de ambos sexos, ingresados en 9 hospitales cubanos con el objetivo de evaluar el efecto del Q-Ulcer (subcitrato de bismuto coloidal y metronidazol en pacientes con diagnóstico endoscópico de gastritis crónica asociada a infección por Hp. Se realizó endoscopia, examen histológico y evaluación clínica antes de comenzar el tratamiento y 4 semanas después de haber finalizado. En treinta y cuatro de estos pacientes se erradicó el Hp con remisión de la gastritis. De los 28 pacientes restantes 14 se incluyeron en la categoría de mejorados y 14 en la de sin respuesta, debido a que el microorganismo se mantuvo positivo, aunque en menor densidad. Los eventos adversos se presentaron en aproximadamente la mitad de los niños y fundamentalmente, durante las dos primeras semanas de tratamiento en que la terapia era combinada. Por esta razón, no se puede precisar que fuera el Q-Ulcer el único responsable de la presencia de estos síntomas, ya que a partir de la tercera semana no se presentaron con la misma frecuencia. La terapia combinada de Q-Ulcer y metronidazol garantizó una apreciable mejoría clínica, endoscópica e histológica, a la vez que resultó segura en el tratamiento de niños portadores de gastritis.

  19. Expression of matrix metalloproteinases 2 and 9 in human gastric cancer and superficial gastritis

    Institute of Scientific and Technical Information of China (English)

    Clara; Luz; Sampieri; Sol; de; la; Pea; Mariana; Ochoa-Lara; Roberto; Zenteno-Cuevas; Kenneth; León-Córdoba

    2010-01-01

    AIM:To assess expression of matrix metalloproteinases 2(MMP2)and MMP9 in gastric cancer,superficial gastritis and normal mucosa,and to measure metalloproteinase activity.METHODS:MMP2 and MMP9 mRNA expression was determined by quantitative real-time polymerase chain reaction.Normalization was carried out using three different factors.Proteins were analyzed by quantitative gelatin zymography(qGZ).RESULTS:18S ribosomal RNA(18SRNA)was very highly expressed,while hypoxanthine ribosyltransferase-1(HPRT-1)was mode...

  20. [Relapse of bleeding ulcer in a 15 year-old boy with collagenous gastritis].

    Science.gov (United States)

    Haase, Anne-Mette; Kelsen, Jens

    2012-06-18

    Collagenous gastritis (CG) is a rare disorder. Two patient groups are known: 1) Children and young adults, presenting with anaemia and abdominal pain, and 2) adults presenting with watery diarrhoea. In the latter group, CG is frequently associated with collagenous colitis and/or coeliac disease. This case concerns a 15-year-old boy with a bleeding ulcer. The biopsies from corpus ventriculi showed a thickened subepithelial collagen band (> 10 micrometres), and the patient was diagnosed with CG. Ulcers are rarely linked to CG. CG should be considered when ulcers are found in children and young adults. PMID:22713227

  1. [Systemic immunological response in children with chronic gingivitis and gastro-intestinal pathology].

    Science.gov (United States)

    Romanenko, E G

    2014-01-01

    Study of the immune system mechanisms in chronic catarrhal gingivitis in children with gastrointestinal pathology was performed in 102 children (49 with chronic gastritis and duodenitis and 53 with no signs of gastrointestinal pathology). Forty-eight children with healthy periodontium constituted control group. Generalized chronic catarrhal gingivitis in children with gastroduodenal pathology is characterized by intense humoral response by simultaneous T-cell immunity suppression. Detection of high serum titers of circulating immune complexes in patients with chronic catarrhal gingivitis suggests a role of immune response in the pathogenesis of periodontal disease increases with concomitant diseases of the upper gastrointestinal tract.

  2. Selenium intoxication with selenite broth resulting in acute renal failure and severe gastritis

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    Kamble P

    2009-01-01

    Full Text Available Selenium (Se is an essential trace element in human and animal nutrition. It is also widely utilized in industrial processes. Reports of acute selenium toxicity in humans are rare. We report a case of a 23-year-old female who consumed about 100 mL of liquid selenite broth and presented with severe nausea, vomiting, abdominal pain, hematemesis and acute renal failure (ARF. The serum selenium level was significantly increased. Gastro-duodenoscopy revealed severe corrosive gastritis. Renal biopsy showed features of acute tubular necrosis (ATN, affecting primarily the proximal tubules. The patient was managed with gastric lavage, blood transfusions, infusion of fresh frozen plasma (FFP and platelet concentrates and hemo-dialysis. The patient was discharged five weeks after admission and her renal functions reco-vered completely by eight weeks after admission. She continues to be on regular follow-up for any possible sequelae of mucosal corrosive damage. This case highlights a case of selenium intoxication from selenite broth resulting in ARF and corrosive gastritis. The recovery was complete.

  3. [Collagenous gastritis and colitis in a 10-year-old girl].

    Science.gov (United States)

    Hangard, P; Lasfargue, M; Rubio, A

    2016-07-01

    There are few data in the literature on microscopic gastritis and colitis in the pediatric population. The diagnosis is often made after the occurrence of complications. We report the case of a 10.5 year-old girl for whom the diagnosis was made several years after the initial symptoms. Test for infections, inflammation, and auto-immunity yielded normal results. Upper endoscopy and colonoscopy revealed an abnormal mucosa. However, histology showed microscopic inflammation and fibrotic lesions in the lamina propria, and a thick subepithelial collagenous band. This led to the diagnosis of collagenous gastritis and colitis. Budesonide treatment resulted in the cessation of diarrhea and significant weight gain. Treatment by oral budesonide indeed seems to be highly effective but relapses are frequent when the treatment is stopped. This case shows the importance of being vigilant regarding transit disorders with impact on growth kinetics. Upper endoscopy and colonoscopy need to be carried out when children have organic diarrhea with normal blood tests. PMID:27266639

  4. A study of Helicobacter pylori -associated gastritis patterns in Iraq and their association with strain virulence

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    Hussein Nawfal

    2009-01-01

    Full Text Available Background/Aim: Helicobacter pylori ( H. pylori infection causes peptic ulceration and gastric adenocarcinoma. In Iraq, gastric cancer is rare. We investigated whether infected adults had the antral-predominant pattern of H. pylori -associated gastritis, which does not predispose to cancer. Materials and Methods: We evaluated histopathological changes by the Sydney scoring system in gastric biopsies taken from 30 H. pylori -infected adults and studied the correlation of these changes with the virulence factors. The Mann-Whitney test was used for the comparison of histopathological data. The presence or absence of each pathological index was evaluated with respect to the possession of virulence factors by the infecting H. pylori strain using the χ2 test. Results: Gastric lymphocyte infiltration was more prominent in the antrum ( P = 0.01. Neutrophil infiltration was mild and gastric mucosal atrophy was rare. No relationship was found between virulence factors and histopathological changes. Conclusions: The mild pathology and antral-predominant gastritis help explain the low cancer rate in Iraq.

  5. Genome-wide analysis of single nucleotide polymorphisms in patients with atrophic age-related macular degeneration in oldest old Han Chinese.

    Science.gov (United States)

    Zhou, T Q; Guan, H J; Hu, J Y

    2015-12-21

    The aim of this study was to identify disease-associated loci in oldest old Han Chinese with atrophic age-related macular degeneration (AMD). This genome-wide association study (GWAS) only included oldest old (≥95 years old) subjects in Rugao County, China. Thirty atrophic AMD patients and 47 age-matched non-AMD controls were enrolled. The study subjects underwent a complete ophthalmic examination. Genomic DNA was extracted from peripheral blood samples. Single nucleotide polymorphisms (SNPs) were scanned by Genome-Wide Human Mapping SNP 6.0 Arrays and GeneChip Scanner 3000 7G. The results were read and analyzed by the Affymetrix Genotyping Console software. We filtered out the SNPs with a no-call rate ≥10%, MAF P old Han Chinese population. This finding may lead to new strategies for screening of atrophic AMD for Han Chinese.

  6. Chronic pancreatitis

    Science.gov (United States)

    Chronic pancreatitis - chronic; Pancreatitis - chronic - discharge; Pancreatic insufficiency - chronic; Acute pancreatitis - chronic ... abuse over many years. Repeated episodes of acute pancreatitis can lead to chronic pancreatitis. Genetics may be ...

  7. Study of T-lymphocyte subsets, nitric oxide, hexosamine and Helicobacter pylori infection in patients with chronic gastric diseases

    Institute of Scientific and Technical Information of China (English)

    Hui Zhang; Shu Lin Jiang; Xi Xian Yao

    2000-01-01

    Chronic gastritis ( CG ) and peptic ulcer ( PU ) are frequently-occurring diseases. It is now well recognized that Helicobacter pylori (Hp) is a major factor that leads to CG and PU[1-8] In order to study the relationship among T lymphocyte subsets, NO, Hexosamine and Hp infection in patients with chronic gastric diseases, the levelsof blood T lymphocyte subsets, plasma NO and hexosamine in gastric mucosa were measured respectively in 30 patients with CG and 32 patients of PU + CG.

  8. Simultaneous Sinus Lifting and Alveolar Distraction of a Severely Atrophic Posterior Maxilla for Oral Rehabilitation with Dental Implants

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    Takahiro Kanno

    2012-01-01

    Full Text Available We retrospectively reviewed a new preimplantation regenerative augmentation technique for a severely atrophic posterior maxilla using sinus lifting with simultaneous alveolar distraction, together with long-term oral rehabilitation with implants. We also analyzed the regenerated bone histomorphologically. This study included 25 maxillary sinus sites in 17 patients. The technique consisted of alveolar osteotomy combined with simultaneous sinus lifting. After sufficient sinus lifting, a track-type vertical alveolar distractor was placed. Following a latent period, patient self-distraction was started. After the required augmentation was achieved, the distractor was left in place to allow consolidation. The distractor was then removed, and osseointegrated implants (average of 3.2 implants per sinus site, 80 implants were placed. Bone for histomorphometric analysis was sampled from six patients and compared with samples collected after sinus lifting alone as controls (n=4. A sufficient alveolus was regenerated, and all patients achieved stable oral rehabilitation. The implant survival rate was 96.3% (77/80 after an average postloading followup of 47.5 months. Good bone regeneration was observed in a morphological study, with no significant difference in the rate of bone formation compared with control samples. This new regenerative technique could be a useful option for a severely atrophic maxilla requiring implant rehabilitation.

  9. Inlay osteotome sinus floor elevation with concentrated growth factor application and simultaneous short implant placement in severely atrophic maxilla

    Science.gov (United States)

    Chen, Yonghui; Cai, Zhiyu; Zheng, Dingguo; Lin, Pei; Cai, Yahua; Hong, Shuxin; Lai, Yiwei; Wu, Dong

    2016-01-01

    Sinus floor elevation with simultaneous implant placement in severely atrophic maxilla is challenging. The aim of this retrospective study was to evaluate the short-term performance of modified osteotome sinus floor elevation (OSFE) with concentrated growth factor (CGF) application and concurrent placement of a short implant in cases with residual bone height (RBH) of 2–4 mm. Twenty-five short implants were installed in 16 patients with mean RBH of 3.23 mm using modified OSFE with CGFs from January 2012 to April 2014. Postoperatively, the implants were clinically evaluated, and vertical bone gain (VBG) was measured using cone beam computed tomography. The mean duration of follow-up was 19.88 months (12–32 months). All the implants were stable with an overall survival rate of 100%. The mean VBG immediately after surgery was 9.21 mm. Six months later, significant reduction of alveolar bone height (2.90 ± 0.22 mm) was found (P  0.05). Within the limits of this study, modified OSFE with CGF application and simultaneous short implant placement could yield predictable clinical results for severely atrophic maxilla with RBH of 2–4 mm. PMID:27250556

  10. Is the presence of Helicobacter pylori in the Dental Plaque of Patients with Chronic Periodontitis a Risk Factor for Gastric Infection?

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    Mohammed Al Asqah

    2009-01-01

    Full Text Available BACKGROUND: Helicobacter pylori is considered to be a pathogen responsible for gastritis and peptic ulcers, and a risk factor for gastric cancer. A periodontal pocket in the teeth of individuals with chronic periodontitis may function as a reservoir for H pylori.

  11. Tetanic contraction induces enhancement of fatigability and sarcomeric damage in atrophic skeletal muscle and its underlying molecular mechanisms.

    Science.gov (United States)

    Yu, Zhi-Bin

    2013-11-01

    Muscle unloading due to long-term exposure of weightlessness or simulated weightlessness causes atrophy, loss of functional capacity, impaired locomotor coordination, and decreased resistance to fatigue in the antigravity muscles of the lower limbs. Besides reducing astronauts' mobility in space and on returning to a gravity environment, the molecular mechanisms for the adaptation of skeletal muscle to unloading also play an important medical role in conditions such as disuse and paralysis. The tail-suspended rat model was used to simulate the effects of weightlessness on skeletal muscles and to induce muscle unloading in the rat hindlimb. Our series studies have shown that the maximum of twitch tension and the twitch duration decreased significantly in the atrophic soleus muscles, the maximal tension of high-frequency tetanic contraction was significantly reduced in 2-week unloaded soleus muscles, however, the fatigability of high-frequency tetanic contraction increased after one week of unloading. The maximal isometric tension of intermittent tetanic contraction at optimal stimulating frequency did not alter in 1- and 2-week unloaded soleus, but significantly decreased in 4-week unloaded soleus. The 1-week unloaded soleus, but not extensor digitorum longus (EDL), was more susceptible to fatigue during intermittent tetanic contraction than the synchronous controls. The changes in K+ channel characteristics may increase the fatigability during high-frequency tetanic contraction in atrophic soleus muscles. High fatigability of intermittent tetanic contraction may be involved in enhanced activity of sarcoplasmic reticulum Ca(2+)-ATPase (SERCA) and switching from slow to fast isoform of myosin heavy chain, tropomyosin, troponin I and T subunit in atrophic soleus muscles. Unloaded soleus muscle also showed a decreased protein level of neuronal nitric oxide synthase (nNOS), and the reduction in nNOS-derived NO increased frequency of calcium sparks and elevated

  12. 疣状胃炎胃黏膜T淋巴细胞亚群变化及其临床意义%Alteration and clinical significance of gastric mucosal T lymphocytes subgroup in verrucous gastritis

    Institute of Scientific and Technical Information of China (English)

    郭春丽; 丁西平; 胡闻; 虞文永; 王巧民

    2012-01-01

    目的 初步检测疣状胃炎胃黏膜CD3 +、CD4 +、CD8 +T细胞的变化,并观察疣状胃炎胃黏膜超微结构改变.方法 采用免疫组化法检测疣状胃炎和慢性浅表性胃炎胃黏膜CD3 +、CD4 +、CD8 +T细胞变化,透射电子显微镜观察疣状胃炎胃黏膜超微结构;14C-呼气试验确定是否有幽门螺杆菌(HP)感染.结果 疣状胃炎较慢性浅表性胃炎CD8 +T细胞明显降低,CD4 +/CD8 +比值明显升高(P<0.05);疣状胃炎HP阳性组较HP阴性组CD3 +、CD4 +、CD8 +T细胞明显升高(P<0.01,P<0.05);疣状胃炎胃黏膜腺上皮细胞结构不同程度破坏,线粒体出现病毒颗粒.结论 疣状胃炎的发生可能与免疫功能紊乱有关,HP、病毒感染可能是导致免疫紊乱的病因.%Objective To investigate the change of gastric mucosal CD3+ ,CD4+ ,CD8+ T lymphocytes and ultra-structures of verrucous gastric mucosa. Methods Gastric mucosal CD3+ ,CD4+ ,CD8+ T lymphocytes in both ver-rucous and chronic superficial gastritis were analyzed by immunohistochemistry, ultrastructures of verrucous gastric mucosa were observed by transmission electron microscope and 14C-urea breath test was used to determine whether patients were infected with helicobacter pylori( HP ). Results The number of CD8+ T lymphocytes decreased significantly and CD4+/CD8+ ratio significantly increased in verrucous gastritis as compared with chronic superficial gastritis ( P <0. 05 ). The number of CD3+ ,CD4+ ,CD8+ T lymphocytes significantly increased in verrucous gastritis of HP positive as compared with HP negative( P < 0. 01 ,P < 0. 05 ). Structures of epithelial cells in verrucous gastritic mucosa were destructed to varying degrees and virosomes were observed in mitochondria. Conclusion The results of this study indicate that the patients with verrucous gastritis may be associated with the immune system dysfunction which may result from both HP and virus infection.

  13. Study on relationship between parvovirus B19 infection and peptic ulcer, superficial gastritis%微小病毒B19与消化性溃疡及浅表性胃炎的相关性研究

    Institute of Scientific and Technical Information of China (English)

    贺湘; 马志胜; 吴护群

    2015-01-01

    目的 分析微小病毒B19在消化性溃疡及浅表性胃炎患者中的表达情况,并对微小病毒B19与消化性溃疡及浅表性胃炎的相关性进行分析.方法 随机选取62例消化性溃疡患者、55例浅表性胃炎患者及60例健康体检者作为观察对象,以消化性溃疡者为A组、以浅表性胃炎者为B组、以健康体检者为C组,分别对三组患者血中微小病毒B19 DNA的阳性率进行分析,并对微小病毒B19与消化性溃疡及浅表性胃炎的相关性进行分析.结果 A组微小病毒B19 DNA阳性率为12.90%,B组微小病毒B19 DNA阳性率为12.73%,C组微小病毒B19 DNA阳性率为1.67%,A组、B组微小病毒B19 DNA阳性率均明显高于C组(P<0.05).同时,微小病毒B19与消化性溃疡及浅表性胃炎均存在显著的相关性(P<0.05).但微小病毒B19 DNA阳性率对消化性溃疡及浅表性胃炎无诊断价值(P>0.05).结论 微小病毒B19 DNA阳性率在消化性溃疡及浅表性胃炎中明显升高,且存在相关性.%Objective To analyze the expression of parvovirus B19 in patients with peptic ulcer and superficial gastritis, and correlation of parvovirus B19 infection and peptic ulcer and chronic superficial.Methods 62 patients with peptic ulcer (group A), 55 cases of superficial gastritis patients (group B) and 60 healthy subjects (group C) were selected as observation objects.Blood were collected from three group and parvovirus B19 DNA was detected , and the correlation of parvovirus B19 with peptic ulcer and chronic superficial gastritis were analyzed.Results The positive rate of parvovirus B19 DNA was 12.90% in group A, the positive rate of B group of parvovirus B19 DNA was 12.73% in group B, 1.67%in group C.There were statistical diffrences between group Aand group C(P < 0.05), group B and group C(P < 0.05).At the same time, parvovirus B19 infection and peptic ulcer, superficial gastritis were significant correlation (P < 0.05).Conclusions There

  14. Bacterial microbiota profiling in gastritis without Helicobacter pylori infection or non-steroidal anti-inflammatory drug use.

    Directory of Open Access Journals (Sweden)

    Xiao-Xing Li

    Full Text Available Recent 16S ribosomal RNA gene (rRNA molecular profiling of the stomach mucosa revealed a surprising complexity of microbiota. Helicobacter pylori infection and non-steroidal anti-inflammatory drug (NSAID use are two main contributors to gastritis and peptic ulcer. However, little is known about the association between other members of the stomach microbiota and gastric diseases. In this study, cloning and sequencing of the 16S rRNA was used to profile the stomach microbiota from normal and gastritis patients. One hundred and thirty three phylotypes from eight bacterial phyla were identified. The stomach microbiota was found to be closely adhered to the mucosa. Eleven Streptococcus phylotypes were successfully cultivated from the biopsies. One to two genera represented a majority of clones within any of the identified phyla. We further developed two real-time quantitative PCR assays to quantify the relative abundance of the Firmicutes phylum and the Streptococcus genus. Significantly higher abundance of the Firmicutes phylum and the Streptococcus genus within the Firmicutes phylum was observed in patients with antral gastritis, compared with normal controls. This study suggests that the genus taxon level can largely represent much higher taxa such as the phylum. The clinical relevance and the mechanism underlying the altered microbiota composition in gastritis require further functional studies.

  15. Chemical reconstruction of skin scars therapy using 100% trichloroacetic acid in the treatment of atrophic facial post varicella scars: A pilot study

    Directory of Open Access Journals (Sweden)

    Nidheesh Agarwal

    2013-01-01

    Full Text Available Context: Chickenpox (varicella is a common viral disease caused by Varicella zoster virus. Facial atrophic scars after varicella infection are not uncommon and pose a cosmetic problem. Like atrophic scars of other aetiologies, they are a difficult condition to treat. There are not enough references in the literature regarding efficient treatment of post varicella scars. High strength Trichloroacetic acid (TCA, which is known to cause dermal collagen remodelling, was used to treat varicella scars in the present study. Aims: The study was undertaken to assess the efficiency of Chemical Reconstruction of Skin Scars (CROSS technique using 100% TCA in the treatment of atrophic facial post varicella scars. Settings and Design: Open label, pilot study. Materials and Methods: A total of 16 patients with atrophic facial post varicella scars were treated by focal application of 100% TCA solution by pressing down upon the scar surface by a toothpick (CROSS technique. Total 4 sittings were given at 2 weekly intervals and the results evaluated after 3 months of follow-up. Statistical analysis was carried out using Fischer′s exact t-test. Results: All of the 13 patients who completed the study showed good clinical improvement, with 69% patients grading the response as excellent (>75% improvement, whereas the rest 31% patients reporting good (51-75% improvement. No significant complications were seen in any patient. Conclusions: CROSS technique using 100% TCA is a safe, cheap and effective therapy for the treatment of post varicella scars.

  16. Editorial: Helicobacter pylori y la patogénesis de la gastritis y la úlcera

    Directory of Open Access Journals (Sweden)

    Luis Eduardo Bravo

    2006-09-01

    Full Text Available Las hazañas trascendentales alcanzadas por la gastroenterología en los últimos cien años han sido mere-cedoras de tres premios Nobel de Medicina y apreciadas por millones de pacientes con úlcera alrededor del mundo. En 1904 Pavlov es premiado por describir los mecanismos neuro-reflejos de la secreción del ácido clorhídrico y en 1988 el equipo de Black por el descubrimiento de los antagonistas de los receptores H2 de histamina. De manera inesperada Marshall y Warren, dos investigadores clínicos australianos reciben el Premio Nobel en el año 2005 por encontrar que el Helicobacter pylori está relacionado con la patogénesis de la gastritis y úlcera péptica. Las investigaciones posteriores a los descubrimientos de Pavlov complementan el conocimiento de la fisiología gástrica al describir los componentes hormonales (gastrina y humorales (histamina de la secreción gástrica. Se propone que la úlcera péptica es consecuencia del exceso de ácido clorhídrico en el estómago y el planteamiento realizado por Schwartz en 1910 guiará el tratamiento de la úlcera péptica durante muchos años. Sin ácido no hay úlcera. La cirugía con sus diversas técnicas de vagotomía no logra el control de la úlcera péptica. Este fracaso impulsa a los farmacólogos a profundizar en el conocimiento de los mecanismos de control hormonal y humoral de la secreción gástrica. Como resultado se desarrollan los medicamentos que bloquean los receptores H2 expresados por las células parietales del estómago, los cuales al ser activados, inducen a las células a producir ácido. Es irónico que Sir James W. Black ganara el Premio Nobel de Medicina en 1988 por el descubrimiento de estos receptores. Su trabajo preparó el camino para el desarrollo de los bloqueadores H2 de histamina y los inhibidores de la bomba de protones. Tales drogas cambiaron el manejo de la enfermedad y finalmente la cirugía quedó limitada a los casos de perforación gástrica. De

  17. Chronic Diarrhea

    Science.gov (United States)

    ... infections that cause chronic diarrhea be prevented? Chronic Diarrhea What is chronic diarrhea? Diarrhea that lasts for more than 2-4 ... represent a life-threatening illness. What causes chronic diarrhea? Chronic diarrhea has many different causes; these causes ...

  18. Work flow for the prosthetic rehabilitation of atrophic patients with a minimal-intervention CAD/CAM approach.

    Science.gov (United States)

    Ciocca, Leonardo; Ragazzini, Sara; Fantini, Massimiliano; Corinaldesi, Giuseppe; Scotti, Roberto

    2015-07-01

    The implant-supported fixed rehabilitation of patients with an atrophic edentulous crest remains a challenge if bone augmentation is not planned. A minimal intervention approach for bone regeneration is necessary to minimize the flap overextension needed to close the defect over the augmented bone. Prosthetically guided bone regeneration can determine the amount of bone augmentation necessary for definitive prosthetic fixed rehabilitation. The positions of the implants and prosthetic restoration were planned; a 0.3 mm thick titanium mesh was customized for bone augmentation by using computer-aided design and computer-aided manufacturing and rapid prototyped by laser sintering, and the definitive prosthetic rehabilitation was carried out according to the initial treatment plan. This resulted in minimal bone augmentation relative to the functional needs of the definitive prosthetic rehabilitation. PMID:25862269

  19. 基于中医胆胃不和理论治疗反流性胃炎的证治初探%Brief Discussion of the Treatment of Reflux Gastritis Based on Disharmony of Gallbladder and Stomach in TCM

    Institute of Scientific and Technical Information of China (English)

    王建云; 杨晋翔

    2015-01-01

    Reflux gastritis is a kind of pathological duodenal gastric regurgitation(DGR),in which the duodenal content is refluxed into the stomach caused by the primary or secondary factors,also called bile reflux gastritis(BRG). This disease is characterized as long duration of sickness and repeated attacks,develo-ping in tendency as from bile reflux gastritis to superficial gastritis,to atrophy,to intestinal metaplasia,to a-typical hyperplasia and gastric cancer. Taught by the academician,Dong Jianhua,Prof. Yang Jinxiang has ac-cumulated rich experiences in the treatment of BRG with TCM. Prof. Yang believes that“disharmony of gall-bladder and stomach”is the basic etiology and pathogenesis of the occurrence and development of reflux gas-tritis. The treatment should focus on regulating the functions of gallbladder and stomach and descending qi. For example,in the case of reversed gallbladder qi attaching stomach and disharmony of ascending and de-scending,the treatment should be harmonizing Shaoyang and regulating stomach qi with modified xiaochaihu tang and xiangsu san. In the case of heat stagnation in gallbladder and stomach and interaction of phlegm and food retention,the treatment should be benefiting gallbladder qi,harmonizing stomach qi,promoting digestion, clearing heat and resolving phlegm with modified haoqin qingdan tang. In the case of chronic sickness with blood stagnation in the interior,the treatment should be activating blood circulation,removing stasis,benefi-ting qi and harmonizing stomach with modified baihe wuyao tang. In the case of stomach yin insufficiency and dysfunction of gallbladder,the treatment should be nourishing yin,benefiting stomach and gallbladder and stopping pain with modified yiguan jian.%反流性胃炎是由于原发或继发因素导致十二指肠内容物反流入胃的一种病理性十二指肠胃反流(DGR),也称为胆汁反流性胃炎(BRG)。该病病程较长,具有反复发作的

  20. Relationship between the Extent of DNA Damage and Gastritis in Normal and Helicobacter pylori-Infected Patients

    OpenAIRE

    Marie, Mohammed Ali M.; Altahir, Isam Elshaikh

    2011-01-01

    Background/Aims The role of Helicobacter pylori in gastric carcinogenesis is unclear, but H. pylori infection is thought to predispose carriers to gastric cancer. The aim of this study was to investigate the relationship between the extent of DNA damage in normal gastric epithelial cells and H. pylori-positive and -negative gastritis according to histological diagnosis. We also compared the percentage of cometed cells on the surface of the gastric epithelial cells to the percentage beneath th...

  1. Isocitrate Dehydrogenase of Helicobacter pylori Potentially Induces Humoral Immune Response in Subjects with Peptic Ulcer Disease and Gastritis

    OpenAIRE

    M Abid Hussain; Naveed, Shaik A.; Sechi, Leonardo A; Sarita Ranjan; Ayesha Alvi; Irshad Ahmed; Akash Ranjan; Sangita Mukhopadhyay; Niyaz Ahmed

    2008-01-01

    BACKGROUND: H. pylori causes gastritis and peptic ulcers and is a risk factor for the development of gastric carcinoma. Many of the proteins such as urease, porins, flagellins and toxins such as lipo-polysaccharides have been identified as potential virulence factors which induce proinflammatory reaction. We report immunogenic potentials of isocitrate dehydrogenase (ICD), an important house keeping protein of H. pylori. METHODOLOGY/PRINCIPAL FINDINGS: Amino acid sequences of H. pylori ICD wer...

  2. Prevalence of H pylori associated 'high risk gastritis' for development of gastric cancer in patients with normal endoscopic findings

    Institute of Scientific and Technical Information of China (English)

    Andreas Leodolter; Matthias P Ebert; Ulrich Peitz; Kathlen Wolle; Stefan Kahl; Michael Vieth; Peter Malfertheiner

    2006-01-01

    AIM: To investigate the prevalence of H pylori associated corpus-predominant gastritis (CPG) or pangastritis, severe atrophy, and intestinal metaplasia (IM) in patients without any significant abnormal findings during upper GI endoscopy.METHODS: Gastric biopsies from 3548 patients were obtained during upper GI-endoscopy in a 4-year period. Two biopsies from antrum and corpus were histologically assessed according to the updated Sydney-System.Eight hundred and forty-five patients (mean age 54.8 ±2.8 years) with H pylori infection and no peptic ulcer or abnormal gross findings in the stomach were identified and analyzed according to gastritis phenotypes using different scoring systems.RESULTS: The prevalence of severe H pylori associated changes like pangastritis, CPG, IM, and severe atrophy increased with age, reaching a level of 20% in patients of the age group over 45 years. No differences in frequencies between genders were observed. The prevalence of IM had the highest increase, being 4-fold higher at the age of 65 years versus in individuals less than 45 years.CONCLUSION: The prevalence of gastritis featuring at risk for cancer development increases with age. These findings reinforce the necessity for the histological assessment, even in subjects with normal endoscopic appearance. The age-dependent increase in prevalence of severe histopathological changes in gastric mucosa, however, does not allow estimating the individual risk for gastric cancer development-only a proper follow-up can provide this information.

  3. Comparison of IL-6, IL-8 Concentrations in H. pylori- and non-H. pylori-associated Gastritis

    Directory of Open Access Journals (Sweden)

    Gontar Alamsyah Siregar

    2014-12-01

    Full Text Available BACKGROUND: Helicobacter pylori is a non-invasive microorganism causing intense gastric mucosal inflammatory and immune reaction. The gastric mucosal levels of the proinflammatory cytokines Interleukin 6 (IL-6 and IL-8 have been reported to be increased in H. pylori infection, but the serum levels in H. pylori infection is still controversial. The purpose of this study was to investigate the serum levels of IL-6 and IL-8 in H. pylori infection. METHODS: A cross sectional study was done on eighty consecutive gastritis patients admitted to endoscopy units at Adam Malik General Hospital and Permata Bunda Hospital, Medan, Indonesia from May-October 2014. Histopathology was performed for the diagnosis of gastritis. Rapid urease test for diagnosis of H. pylori infection. Serum samples were obtained to determine circulating IL-6 and IL-8. Univariate and bivariate analysis (independent t test were done. RESULTS: There were 41.25% patients infected with H. pylori. Circulatory IL-6 levels were significantly higher in H. pylori-infected patients compared to H. pylori negative, but there were no differences between serum levels of IL-8 in H. pylori positive and negative patients. CONCLUSIONS: The immune response to H. pylori promotes systemic inflammation, which was reflected in an increased level of serum IL-6. Serum levels of IL-8 were not significantly different between H. pylori positive and negative. KEYWORDS: Helicobacter pylori, gastritis, IL-6, IL-8, cytokine.

  4. Multiple carcinoids in the duodenum, pancreas and stomach accompanied with type A gastritis: A case report

    Institute of Scientific and Technical Information of China (English)

    Takeo Bamba; Shin-ichi Kosugi; Tatsuo Kanda; Toshihiro Tsubono; Yasuo Sakai; Nobuyuki Musha; Noriko Ishihara; Katsuyoshi Hatakeyama

    2007-01-01

    We report a case of multiple duodenal, pancreatic, and gastric carcinoids. A 67-year old woman was admitted to our hospital for treatment of a duodenal carcinoid.Laboratory tests revealed that the patient was associated with macrocytic anemia and hypergastrinemia, and type A gastritis was shown by gastrofiberscopy.During surgery, another tumor was incidentally found in the head of the pancreas. The tumors in the duodenum and pancreas were completely excised by pancreatoduodenectomy and immunohistologically diagnosed as gastrin-and serotonin-producing carcinoids,respectively. Pathological examination revealed that in addition to the grossly found carcinoids, there were subclinical carcinoids, one of which was an endocrine cell micronest, located in the stomach and duodenum.The tumors in the duodenum, pancreas, and stomach showed different characteristics from one another morphologically and immunochemically. Although no definitive evidence has been obtained, some sort of genetic anomaly may have been involved in this case,and hypergastrinemia due to duodenal gastrinoma may induce multiple gastric carcinoids.

  5. Overexpression of Caspase-1 in adenocarcinoma of pancreas and chronic pancreatitis

    Institute of Scientific and Technical Information of China (English)

    Yin-Mo Yang; Marco Ramadani; Yan-Ting Huang

    2003-01-01

    AIM: To identify the expression of Caspase-l(interleukin1.β converting enzyme) and its role in adenoma of the pancreas and chronic pancreatitis.METHODS: The expression of Caspase-1 was assessed in 42 pancreatic cancer tissue samples, 38 chronic pancreatitis specimens, and 9 normal pancreatic tissues by immunohistochemistry and Western blot analysis.RESULTS: Overexpression of Caspase-1 was observed in both disorders, but there were differences in the expression patterns in distinct morphologic compartments. Pancreatic cancer tissues showed a clear cytoplasmatic overexpression of Caspase-1 in tumor cells of 71% of the tumors, whereas normal pancreatic tissues showed only occasional immunoreactivity. In chronic pancreatitis, overexpression of Caspase-1 was found in atrophic acinar cells (89 %),hyperplastic ducts (87 %), and dedifferentiating acinar cells (84 %). Although in atrophic cells a clear nuclear expression was found, hyperplastic ducts and dedifferentiating acinar cells showed dear cytoplasmic expression. Western blot analysis revealed a marked expression of the 45 kDa precursor of Caspase-1 in pancreatic cancer and chronic pancreatitis (80 %and 86 %, respectively). Clear bands at 30 kDa, which suggested the p10-p20 heterodimer of active Caspase-1, were found in 60 % of the cancer tissue and 14 % of the pancreatitis tissue specimens, but not in normal pancreatic tissues.CONCLUSION: Overexpression of Caspase-1 is a frequent event in pancreatic disorders and its differential expression patterns may reflect two functions of the protease. One is its participation in the apoptotic pathway in atrophic acinar cells and tumor-surrounding pancreatitis tissue, the other is its possible role in proliferative processes in pancreatic cancer cells and hyperplastic duct cells and dedifferentiating acinar cells in chronic pancreatitis.

  6. Adjunctive hyperbaric oxygen therapy in the treatment of atrophic tibial nonunion with Ilizarov external fixator: a radiographic and scintigraphic study in rabbits*

    OpenAIRE

    Kurklu, Mustafa; Yurttas, Yuksel; Kose, Ozkan; Demiralp, Bahtiyar; Yuksel, Halil Yalcin; Komurcu, Mahmut

    2012-01-01

    Objective: The aim of this experimental study was to determine the effects of adjunctive hyperbaric oxygen therapy (HBO) on atrophic tibial nonunion treatment using Ilizarov external fixator. Methods: Twenty New Zealand white rabbits were randomly divided into two equal groups. A circular external fixator was applied to the right tibia of all the rabbits. A 5-mm bone block was resected and a tibial pseudarthrosis was obtained after a 6-month waiting period. The experimental group rabbits ...

  7. Selection of housekeeping genes for gene expression studies in the adult rat submandibular gland under normal, inflamed, atrophic and regenerative states

    Directory of Open Access Journals (Sweden)

    Osailan Samira

    2008-07-01

    Full Text Available Abstract Background Real-time PCR is a reliable tool with which to measure mRNA transcripts, and provides valuable information on gene expression profiles. Endogenous controls such as housekeeping genes are used to normalise mRNA levels between samples for sensitive comparisons of mRNA transcription. Selection of the most stable control gene(s is therefore critical for the reliable interpretation of gene expression data. For the purpose of this study, 7 commonly used housekeeping genes were investigated in salivary submandibular glands under normal, inflamed, atrophic and regenerative states. Results The program NormFinder identified the suitability of HPRT to use as a single gene for normalisation within the normal, inflamed and regenerative states, and GAPDH in the atrophic state. For normalisation to multiple housekeeping genes, for each individual state, the optimal number of housekeeping genes as given by geNorm was: ACTB/UBC in the normal, ACTB/YWHAZ in the inflamed, ACTB/HPRT in the atrophic and ACTB/GAPDH in the regenerative state. The most stable housekeeping gene identified between states (compared to normal was UBC. However, ACTB, identified as one of the most stably expressed genes within states, was found to be one of the most variable between states. Furthermore we demonstrated that normalising between states to ACTB, rather than UBC, introduced an approximately 3 fold magnitude of error. Conclusion Using NormFinder, our studies demonstrated the suitability of HPRT to use as a single gene for normalisation within the normal, inflamed and regenerative groups and GAPDH in the atrophic group. However, if normalising to multiple housekeeping genes, we recommend normalising to those identified by geNorm. For normalisation across the physiological states, we recommend the use of UBC.

  8. Ablative non-fractional lasers for atrophic facial acne scars: a new modality of erbium:YAG laser resurfacing in Asians.

    Science.gov (United States)

    Lee, Sang Ju; Kang, Jin Moon; Chung, Won Soon; Kim, Young Koo; Kim, Hei Sung

    2014-03-01

    Atrophic facial scars which commonly occur after inflammatory acne vulgaris can be extremely disturbing to patients both physically and psychologically. Treatment with fractional laser devices has become increasingly popular, but there has been disappointment in terms of effectiveness. The objective of this study was to assess the safety and efficacy of ablative full-face resurfacing on atrophic acne scars in the Korean population. A total of 22 patients, aged 25-44 years, underwent a new modality of resurfacing combining both short-pulsed and dual-mode erbium:yttrium-aluminum garnet (Er:YAG) laser. The patients had Fitzpatrick skin types ranging from III to V. Photographs were taken before and up to 6 months after treatment. Results were evaluated for the degree of clinical improvement and any adverse events. Degree of improvement was graded using a four-point scale: poor (1) = 75%. Based on the blinded photo assessments by two independent reviewers, clinically and statistically significant mean improvement of 3.41 was observed (one-sample Wilcoxon signed rank test, P laser resurfacing combining short-pulsed and dual-mode Er:YAG laser is a safe and very effective treatment modality for atrophic facial acne scars in Asians with darker skin tones.

  9. Atrophic dermatofibrosarcoma protuberans with the fusion gene COL1A1-PDGFB detected by RT-PCR using only a single primer pair.

    Science.gov (United States)

    Xu, Wen-Jun; Wang, Ju-Sheng

    2015-01-01

    Dermatofibrosarcoma protuberans (DFSPs) is an uncommon dermal tumor of intermediate to low-grade malignancy. A few patients have clinically persistent plaques that might be atrophic, and they are difficult to be diagnosed clinically. With the development of cytogenetic and molecular biology techniques, the detection of fusion transcripts of the collagen type 1a1 (COL1A1) and platelet-derived growth factor-BB (PDGFB) genes has been recognized as a reliable and valuable molecular tool for the diagnosis of DFSPs. We reported a 24-year-old woman who had a 2 years history of atrophic DFSPs, and detected the gene fusion between COL1A1 to PDGFB by one-step method of RT-PCR using only a single primer pair. The gene fusion detected by this rapid and efficient one-step method in our patient appears to be the first report of atrophic DFSPs, and we detected a novel COL1A1 breakpoint between exon 2 and exon 3.

  10. Gastric Ollulanus tricuspis infection identified in captive cheetahs (Acinonyx jubatus with chronic vomiting : case report

    Directory of Open Access Journals (Sweden)

    M.G. Collett

    2000-07-01

    Full Text Available Gastritis, vomition and weight loss are common in captive cheetahs (Acinonyx jubatus. Gastric spiral bacteria (Helicobacter spp. and the very small, viviparous nematode Ollulanus tricuspis, a stomach worm of cats, are believed to be important causes. Three sibling cheetahs at Wellington Zoo, New Zealand, developed chronic vomiting, diarrhoea and debility. Their parents were both South African-born. Response to antibacterial treatment was poor. Endoscopic examinations revealed chronic lymphoplasmacytic gastritis and Ollulanus infection. Treatment with oxfendazole and pyrantel embonate resulted in clinical improvement; however, 1 cheetah, which died 7 months later as a result of a ruptured liver due to hepatic amyloidosis, still had Ollulanus worms present in her stomach. Ollulanus tricuspis is a significant cause of gastritis and vomiting in captive cheetahs, lions and tigers, as well as wild cougars and tigers. The parasite has not yet been found in sub-Saharan Africa. Because of the unusual characteristics of this parasite, the literature on its life history and techniques for diagnosis is reviewed.

  11. [Disturbances of gastrointestinal motility of the stomach in patients with chronic gastric erosions and biliary tract disease].

    Science.gov (United States)

    Svintsitskyĭ, A S; Solovĭova, H A

    2012-12-01

    Article dwells on comparison data about motor function of the stomach in the three groups of patients: with gastric erosions and biliary tract diseases, duodenal ulcer disease, chronic gastritis. It is shown, that patients with gastric erosions and biliary tract diseases are characterized by slower evacuation function of the stomach, hypotonus of the stomach. Frequency of duodenal reflux in this group of patients is very high (85,9 %).

  12. Atrophic thyroid follicles and inner ear defects reminiscent of cochlear hypothyroidism in Slc26a4-related deafness.

    Science.gov (United States)

    Dror, Amiel A; Lenz, Danielle R; Shivatzki, Shaked; Cohen, Keren; Ashur-Fabian, Osnat; Avraham, Karen B

    2014-08-01

    Thyroid hormone is essential for inner ear development and is required for auditory system maturation. Human mutations in SLC26A4 lead to a syndromic form of deafness with enlargement of the thyroid gland (Pendred syndrome) and non-syndromic deafness (DFNB4). We describe mice with an Slc26a4 mutation, Slc26a4 (loop/loop) , which are profoundly deaf but show a normal sized thyroid gland, mimicking non-syndromic clinical signs. Histological analysis of the thyroid gland revealed defective morphology, with a majority of atrophic microfollicles, while measurable thyroid hormone in blood serum was within the normal range. Characterization of the inner ear showed a spectrum of morphological and molecular defects consistent with inner ear pathology, as seen in hypothyroidism or disrupted thyroid hormone action. The pathological inner ear hallmarks included thicker tectorial membrane with reduced β-tectorin protein expression, the absence of BK channel expression of inner hair cells, and reduced inner ear bone calcification. Our study demonstrates that deafness in Slc26a4 (loop/loop) mice correlates with thyroid pathology, postulating that sub-clinical thyroid morphological defects may be present in some DFNB4 individuals with a normal sized thyroid gland. We propose that insufficient availability of thyroid hormone during inner ear development plays an important role in the mechanism underlying deafness as a result of SLC26A4 mutations.

  13. Use of Narrow-Diameter Implants in Treatment of Severely Atrophic Maxillary Anterior Region With Implant-Supported Fixed Restorations.

    Science.gov (United States)

    Froum, Stuart J; Cho, Sang-Choon; Florio, Salvatore; Misch, Craig M

    2016-05-01

    The edentulous anterior atrophic maxilla represents a challenge for the surgeon and restorative dentist. Soft- and hard-tissue augmentation procedures are often required prior to, or simultaneously with, implant placement. A well-planned treatment protocol, patient compliance, and collaboration between the treating clinicians and the laboratory are requirements in achieving predictable long-term outcomes that satisfy patient expectations. Avoiding transmucosal loading and movement of the graft during the healing phase are crucial factors in achieving lasting success. In this case report, a fixed provisional restoration supported by four immediately loaded narrow-diameter implants (NDIs) was used to enable function during healing and protect the grafted site. Two of the NDIs, along with three conventional-diameter implants, were subsequently used to support the final restoration. NDIs with diameters of less than 3 mm can achieve excellent long-term osseointegration and may be used together with conventional implants for definitive prosthodontic treatment as demonstrated by the 11-year follow-up reported in this case. PMID:27213779

  14. Single-stage implantation in the atrophic alveolar ridge of the mandible with the Norian skeletal repair system.

    Science.gov (United States)

    Hölzle, Frank; Bauer, Florian; Kesting, Marco R; Mücke, Thomas; Deppe, Herbert; Wolff, Klaus-Dietrich; Swaid, Sami

    2011-10-01

    Dental implants have played a part in rehabilitation of the jaws for more than 40 years, but in some cases they alone are inadequate because of extreme alveolar resorption. Correction may necessitate a two-stage procedure with additional interventions. We have made a preliminary study of the use of the Norian skeletal repair system (SRS), a carbonated calcium phosphate bone cement used to augment the alveolar ridge as a single-stage procedure, with the placement of implants. Ten edentulous patients with insufficient vertical bone in the interforaminal area were treated. After a horizontal osteotomy and crestal mobilisation of the alveolar ridge, implants were placed through the crestal part and fixed in the basal part of the mandible. Norian SRS was used to fill the gap created. The prostheses were inserted 3 months later. Forty implants were inserted. The follow up period was 60 months, and no fractures or dislocations developed. One of the implants was lost and there was one wound dehiscence, but no surgical intervention or revision was necessary. Radiographs showed good consolidation of the bony structure in all cases. We have described a reliable, single-stage procedure for augmentation and implantation in a highly atrophic alveolar crest. A 98% survival is comparable with those of other techniques. Further clinical trials are necessary to replicate these promising results.

  15. Immunogenicity and efficacy of three recombinant subunit Pasteurella multocida toxin vaccines against progressive atrophic rhinitis in pigs

    Science.gov (United States)

    Liao, Chih-Ming; Huang, Chienjin; Hsuan, Shih-Ling; Chen, Zeng-Weng; Lee, Wei-Cheng; Liu, Cheng-I; Winton, James R.; Chien, Maw-Sheng

    2006-01-01

    Three short fragments of recombinant subunit Pasteurella multocida toxin (rsPMT) were constructed for evaluation as candidate vaccines against progressive atrophic rhinitis (PAR) of swine. PMT-specific antibody secreting cells and evidence of cellular immunity were detected in rsPMT-immunized pigs following authentic PMT challenge or homologous antigen booster. Piglets immunized with rsPMT fragments containing either the N-terminal or the C-terminal portions of PMT developed high titers of neutralizing antibodies. Pregnant sows immunized with rsPMT had higher levels of maternal antibodies in their colostrum than did those immunized with a conventional PAR-toxoid vaccine. Offspring from rsPMT vaccinated sows had better survival after challenge with a five-fold lethal dose of authentic PMT and had better growth performance after challenge with a sublethal dose of toxin. Our findings indicate these non-toxic rsPMT proteins are attractive candidates for development of a subunit vaccine against PAR in pigs.

  16. Helicobacter pylori associated gastric intestinal metaplasia: Treatment and surveillance

    OpenAIRE

    Liu, Kevin Sze-Hang; Wong, Irene Oi-Ling; Leung, Wai K.

    2016-01-01

    Gastric cancer (GC) is one of the leading causes of cancer related death in the world, particularly in East Asia. According to the Correa’s cancer cascade, non-cardia GC is usually developed through a series of mucosal changes from non-atrophic gastritis to atrophic gastritis (AG), intestinal metaplasia (IM), dysplasia and adenocarcinoma. Atrophic gastritis and IM are therefore generally considered to be pre-neoplastic gastric lesions. Helicobacter pylori (H. pylori) infection is an important...

  17. Possibility of non-invasive diagnosis of gastric mucosal precancerous changes

    Institute of Scientific and Technical Information of China (English)

    Victor D. Pasechnikov; Sergey Z. Chukov; Sergey M. Kotelevets; Alexander N. Mostovov; Varvara P. Mernova; Maria B. Polyakova

    2004-01-01

    AIM: To assess the possibility of non-invasive screening of atrophic chronic gastritis for preventing further development of gastric cancer.METHODS: One hundred and seventy-eight consecutive Helicobacter pylori ( H pylori)-positive dyspeptic patients after detection of serum levels of pepsinogen-1 (PG-1) and gastrin-17 (G-17) by enzyme immunoassay were proposed for endoscopy and histology. The serologic and morphologic results were compared with estimating the sensitivity,specificity and prognostic values of the tests.RESULTS: There was statistically significant reverse dependence between the grade of stomach mucosal antral or corpus atrophy and the proper decreasing of serum G17or PG1 levels. The serologic method was quite sensitive in the diagnosis of non-atrophic and severe antral and corpus gastritis. Also, it was characterized by the high positive and negative prognostic values.CONCLUSION: Detection of serum G-17 and PG1 levels can be offered as the screening tool for atrophic gastritis. The positive serologic results require further chromoendoscopy with mucosal biopsy, for revealing probable progressing of atrophic process with development of intestinal metaplasia,dysplasia or gastric cancer.

  18. Russell body gastritis: case report Gastrite com corpúsculos de Russell: relato de caso

    Directory of Open Access Journals (Sweden)

    Eduardo Cambruzzi

    2012-02-01

    Full Text Available Russell body gastritis (RBG, which can be associated with Helicobacter pylori (HP infection, is a recently acknowledged lesion characterized by the presence of eosinophilic intracytoplasmic inclusions in plasmacytes. Herein the authors discuss the morphological aspects of a case of RBG in a male patient with clinical complaint of epigastric pain. Upper endoscopy revealed areas of erythema/edema in the antrum. As far as microscopy is concerned, a mononuclear inflammatory infiltrate was identified on the lamina propria, with plasma cells containing Schiff acid periodic (PAS positive eosinophilic intracytoplasmic globules, which showed positive immunostaining for CD79a, CD138, and kappa/lambda light chains. HP was identified by Giemsa stains.A gastrite com corpúsculos de Russell (RBG, que pode estar associada à infecção por Helicobacter pylori (HP, é uma lesão recentemente reconhecida que se caracteriza pela presença de inclusões eosinofílicas intracitoplasmáticas em plasmócitos. Neste relato, os autores discutem os aspectos morfológicos de um caso de RBG em um paciente masculino com queixa clínica de dor epigástrica. A endoscopia revelou áreas de eritema/edema no antro. À microscopia, um infiltrado inflamatório mononuclear foi identificado na lâmina própria, com plasmócitos exibindo glóbulos eosinofílicos intracitoplasmáticos ácido periódico de Schiff (PAS positivos, que apresentaram imunoexpressão positiva para CD79a,CD138 e cadeias leves kappa/lambda. HP foi identificado na coloração de Giemsa.

  19. Furazolidone-based triple therapy for H pylori gastritis in children

    Institute of Scientific and Technical Information of China (English)

    Elisabete Kawakami; Rodrigo Strehl Machado; Silvio Kazuo Ogata; Marini Langner; Erika Fukushima; Anna Paula Carelli; Vania Cláudia Guimar(a)es Bonucci; Francy Reis Silva Patrício

    2006-01-01

    AIM: To evaluate the furazolidone-based triple therapy in children with symptomatic H pylori gastritis.METHODS: A prospective and consecutive open trial was carried out. The study included 38 patients withupper digestive symptoms sufficiently severe to warrant endoscopic investigation.H pylori status was defined based both on histology and on positive 13C-urea breath test. Drug regimen was a seven-day course of omeprazole, clarithromycin and furazolidone (100 mg, 200 mg if over 30 kg) twice daily. Eradication of H pylori was assessed two months after treatment by histology and 13C-urea breath test. Further clinical evaluation was performed 7 d, 2 and 6 mo after the treatment. RESULTS: Thirty-eight patients (24 females, 14 males)were included. Their age ranged from 4 to 17.8 (mean 10.9 ± 3.7) years. On intent-to-treat analysis (n = 38),the eradication rate of H pylori was 73.7% (95% CI,65.2%-82%) whereas in per-protocol analysis (n = 33) it was 84.8% (95% CI, 78.5%-91%). All the patients with duodenal ulcer (n = 7) were successfully treated (100% vs 56.2% with antral nodularity). Side effects were reported in 26 patients (68.4%), mainly vomiting (14/26) and abdominal pain (n = 13). Successfully treated dyspeptic patients showed improvement in 78.9% of H pylori-negative patients after six months and in 50% of H pylori-positive patients after six months of treatment.CONCLUSION: Triple therapy with furazolidone achieves moderate efficacy in H pylori treatment. The eradication rate seems to be higher in patients with duodenal ulcer.

  20. Frontal fibrosing alopecia and lichen planopilaris in HLA-identical mother and daughter

    Directory of Open Access Journals (Sweden)

    María Mercedes Otero Rivas

    2015-01-01

    Full Text Available Frontal fibrosing alopecia (FFA is a lymphocyte-mediated scarring alopecia thought to be a variant of lichen planopilaris (LPP. We present a 67-year-old woman with frontal fibrosing alopecia whose daughter was diagnosed to have lichen planopilaris. Both patients had identical human leukocyte antigen (HLA D types, supporting a phenotypical relationship between the two clinical entities. Interestingly, our patient also had of autoimmune chronic atrophic gastritis, a previously unreported association.

  1. Should antiplatelet therapy be interrupted in drug eluting stent recipients throughout the periendoscopic period? A very late stent thrombosis case report and review of the literature

    OpenAIRE

    Dong, Peng; Yang, Xin-Chun; Bian, Su-Yan

    2014-01-01

    In-stent thrombosis after cessation of antiplatelet medications in patients with drug-eluting stents (DES) is a significant problem in medical practice, particularly in the perioperative period. We report a case of an 87-year-old man with a medical history of hypertension, coronary artery disease and chronic atrophic gastritis. Very late thrombosis of a sirolimus-eluting stent occurred 1207 days after implantation, seven months after discontinuation of clopidogrel, and the interruption of asp...

  2. Isocitrate dehydrogenase of Helicobacter pylori potentially induces humoral immune response in subjects with peptic ulcer disease and gastritis.

    Directory of Open Access Journals (Sweden)

    M Abid Hussain

    Full Text Available BACKGROUND: H. pylori causes gastritis and peptic ulcers and is a risk factor for the development of gastric carcinoma. Many of the proteins such as urease, porins, flagellins and toxins such as lipo-polysaccharides have been identified as potential virulence factors which induce proinflammatory reaction. We report immunogenic potentials of isocitrate dehydrogenase (ICD, an important house keeping protein of H. pylori. METHODOLOGY/PRINCIPAL FINDINGS: Amino acid sequences of H. pylori ICD were subjected to in silico analysis for regions with predictably high antigenic indexes. Also, computational modelling of the H. pylori ICD as juxtaposed to the E. coli ICD was carried out to determine levels of structure similarity and the availability of surface exposed motifs, if any. The icd gene was cloned, expressed and purified to a very high homogeneity. Humoral response directed against H. pylori ICD was detected through an enzyme linked immunosorbent assay (ELISA in 82 human subjects comprising of 58 patients with H. pylori associated gastritis or ulcer disease and 24 asymptomatic healthy controls. The H. pylori ICD elicited potentially high humoral immune response and revealed high antibody titers in sera corresponding to endoscopically-confirmed gastritis and ulcer disease subjects. However, urea-breath-test negative healthy control samples and asymptomatic control samples did not reveal any detectable immune responses. The ELISA for proinflammatory cytokine IL-8 did not exhibit any significant proinflammatory activity of ICD. CONCLUSIONS/SIGNIFICANCE: ICD of H. pylori is an immunogen which interacts with the host immune system subsequent to a possible autolytic-release and thereby significantly elicits humoral responses in individuals with invasive H. pylori infection. However, ICD could not significantly stimulate IL8 induction in a cultured macrophage cell line (THP1 and therefore, may not be a notable proinflammatory agent.

  3. Mucosal patterns of Helicobacter pylori-related gastritis without atrophy in the gastric corpus using standard endoscopy

    Institute of Scientific and Technical Information of China (English)

    Shwu-Tzy; Wu; Chien-Hua; Chen; Yeh-Huang; Hung; Tsung-Hsun; Yang; Vun-Siew; Pang; Yung-Hsiang; Yeh

    2010-01-01

    AIM:To identify the mucosal patterns of Helicobacter pylori(H.pylori )-related gastritis in the gastric corpus using standard endoscopy and to evaluate their reproducibility.METHODS:A total of 112 consecutive patients underwent upper gastrointestinal endoscopy.The endoscopists classified the endoscopic findings into 4 patterns.In the second part of the study,90 images were shown to 3 endoscopists in order to evaluate the inter-observer and intra-observer variability in image assessment.RESULTS:The mucosal p...

  4. Prevalência da infecção por Helicobacter pylori e das lesões precusoras do câncer gástrico em pacientes dispéticos Prevalence of Helicobacter pylori infection and gastric cancer precursor lesions in patients with dyspepsia

    Directory of Open Access Journals (Sweden)

    Leandro Bizarro Muller

    2007-06-01

    foi menor que 1. CONCLUSÃO: A prevalência da infecção por H. pylori foi alta (76% e os indivíduos infectados apresentaram probabilidade 10 vezes maior para a ocorrência de lesão da mucosa gástrica. Gastrite crônica não-atrófica apresentou prevalência de 77%, gastrite atrófica 3% e metaplasia intestinal 15%. A infecção pelo H. pylori determinou uma probabilidade 3 vezes maior para o desenvolvimento de gastrite crônica não-atrófica e não determinou risco para a ocorrência de gastrite atrófica e metaplasia intestinal, sugerindo que possivelmente outros fatores de risco, além do H. pylori, estejam envolvidos no processo da carcinogênese gástrica.BACKGROUND: Helicobacter pylori infection has been considered to play significant role in gastric carcinogenesis, but only a minority of people who harbor this organism will develop gastric cancer. H. pylori infection first causes chronic non atrophic gastritis. Chronic non atrophic gastritis may evolve to atrophic gastritis and intestinal metaplasia and finally to dysplasia and adenocarcinoma. AIMS: To estimate the prevalence of H. pylori infection and the precancerous gastric lesions and their relationship, in patients with dyspeptic symptoms who underwent upper gastrointestinal endoscopy at a reference center in the central region of Rio Grande do Sul state, Brazil. METHODS: We analyzed gastric biopsies taken from corpus and antrum of patients who underwent upper gastrointestinal endoscopy for H. pylori detection, between 1994 and 2003. According to Sydney system, chronic non atrophic gastritis, atrophic gastritis and intestinal metaplasia were diagnosed by histological examination (H-E stain. The histological diagnoses were related to H. pylori infection status. RESULTS: Biopsies from 2,019 patients were included in the study. Patients mean age was 52 (±15 and 59% were female. Seventy six percent had H. pylori infection. Normal mucosa, chronic non atrophic gastritis, atrophic gastritis and intestinal

  5. The expression and clinical significance of new suppressor gene RASSF1 in gastric-carcinoma%抑癌基因PASSF1在胃癌中的表达及临床意义

    Institute of Scientific and Technical Information of China (English)

    Xueyan Li; Baoyu Fu; Chaosheng Lin

    2008-01-01

    Objective:To investigate the expression lose rates of two kinds different RASSF1 transcripts RASSF1A,RASSF1B in gastric-carcinoma and benign gastric disease and discuss their relations to clinical significance.Methods:The mRNA expressions of RASSF1A and RASSF1B were detected by RT-PCR in 32 patients with gastric-carcinoma,32 with adjacent non-carcinomatous gastric tissues and 51 cases with benign gastric disease (include 30 chronic shallow gastritis and 21 chronic atrophic gastritis).Results:The rates of expression loss of transcripts A and B in gastric-carcinoma were 59.3% (19/32) and 28.2% (9/32),10% (3/30) and 6.7% (2/30) in chronic shallow gastritis (CSG),28.6% (6/21) and 14.3% (3/21) in chronic atrophic gastritis (CAG),respectively.The rates of expression loss of transcripts A and B in adjacent noncarcinomatous were 0.RASSF1A and RASSF1B mRNA expressions had no statistical relations with different grade of gastriccarcinoma.Conclusion:The two different RASSF1 transcripts RASSF1A and RASSF1B were almost expressed in adjacent non-carcinomatous gastric tissues.RASSF1A had a significant expression loss in gastric-carcinoma,and has no statistical relation with different grade of gastric-carcinoma.The result indicated that RASSF1A was a suppressor gene.

  6. Longitudinal analysis of osteogenic and angiogenic signaling factors in healing models mimicking atrophic and hypertrophic non-unions in rats.

    Directory of Open Access Journals (Sweden)

    Susann Minkwitz

    Full Text Available Impaired bone healing can have devastating consequences for the patient. Clinically relevant animal models are necessary to understand the pathology of impaired bone healing. In this study, two impaired healing models, a hypertrophic and an atrophic non-union, were compared to physiological bone healing in rats. The aim was to provide detailed information about differences in gene expression, vascularization and histology during the healing process. The change from a closed fracture (healing control group to an open osteotomy (hypertrophy group led to prolonged healing with reduced mineralized bridging after 42 days. RT-PCR data revealed higher gene expression of most tested osteogenic and angiogenic factors in the hypertrophy group at day 14. After 42 days a significant reduction of gene expression was seen for Bmp4 and Bambi in this group. The inhibition of angiogenesis by Fumagillin (atrophy group decreased the formation of new blood vessels and led to a non-healing situation with diminished chondrogenesis. RT-PCR results showed an attempt towards overcoming the early perturbance by significant up regulation of the angiogenic regulators Vegfa, Angiopoietin 2 and Fgf1 at day 7 and a further continuous increase of Fgf1, -2 and Angiopoietin 2 over time. However µCT angiograms showed incomplete recovery after 42 days. Furthermore, lower expression values were detected for the Bmps at day 14 and 21. The Bmp antagonists Dan and Twsg1 tended to be higher expressed in the atrophy group at day 42. In conclusion, the investigated animal models are suitable models to mimic human fracture healing complications and can be used for longitudinal studies. Analyzing osteogenic and angiogenic signaling patterns, clear changes in expression were identified between these three healing models, revealing the importance of a coordinated interplay of different factors to allow successful bone healing.

  7. Fuentes de variabilidad en el diagnóstico de gastritis atrófica multifocal asociada con la infección por Helicobacter pylori

    OpenAIRE

    Luis Eduardo Bravo; Juan Carlos Bravo; José Luis Realpe

    2008-01-01

    Introducción: El mapeo de las diferentes regiones del estómago y el número de fragmentos de mucosa gástrica disponibles para evaluación histopatológica son fuentes importantes de variación en el momento de clasificar y hacer la gradación de la gastritis crónica. Objetivos: Estimar la sensibilidad del número de fragmentos de mucosa gástrica necesarios para establecer los diagnósticos de gastritis atrófica con metaplasia intestinal (MI), displasia y estado de infección por Helicobacter pylori. ...

  8. Gastrointestinal amyloidosis: a case of chronic diarrhoea.

    Science.gov (United States)

    Fonnesu, C; Giovinale, M; Verrecchia, E; De Socio, G; Cerquaglia, C; Curigliano, V; Soriano, A; Obici, L; Grieco, A; Lauriola, L; Gasbarrini, G; Manna, R

    2009-03-01

    Amyloidosis is a rare disease caused by extracellular deposits of insoluble fibrillar proteins in various organs and tissues. There are different forms of amyloidosis distinguished by the type of protein fibrils, by the sites of deposition and by associated conditions. Gastrointestinal involvement is common both in primary and secondary amyloidosis, while isolated gastrointestinal amyloidosis is rare. We describe a case of AL amyloidosis with a gastrointestinal involvement and restrictive cardiomiopathy. A 64 year old woman came to our attention with a history of chronic diarrhoea and weight loss, associated with dysphagia, dry mouth, xerophtalmia, chronic gastritis and depression. Clinical diagnosis has been difficult because of aspecificity of symptoms that mimed other more common diseases, like gastro-paresis, epigastric discomfort, gastric or duodenal ulcers, perforation, malabsorption, intestinal pseudo-obstruction. There is an important risk of misunderstanding and diagnostic delay. Indeed in this patient a diagnosis of irritable colon syndrome was erroneously established two years before admission in our hospital. Therefore gastrointestinal amyloidosis should be considered among differential diagnoses of chronic diarrhoea and weight loss when other more common diseases have been excluded. PMID:19530511

  9. RULE OF CARCINOGENETIC DEVELOPMENT OF GASTRIC CARDIA OBSERVED BY ENDOSCOPY

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Objective: To study the rule of development of early cancer of gastric cardiac in vivo. Methods: A prospective cohort was held in the high incidence area of cancer of esophagus and stomach in china. One hundred and six persons were examined regularly by endoscopy to observe the change of pro-cancer lesions of gastric cardiac by taking biopsy specimen. All specimens were diagnosed through normal pathological process. Results: The 106 subjects were examined twice in 1998 and 2002. Of 8 normal persons, 3 stayed normal, 4 turned to chronic gastritis, 1 developed early gastric cardiac cancer. Of 61 persons with chronic gastritis, 11 were observed to have gland atrophy, 4 with mild atypical hyperplasia, and 2 with highly atypical hyperplasia. Of 9 subjects showing atrophic chronic gastritis, 5 revealed no change, and 4 became chronic gastritis. Of 22 subjects who revealed mild atypical hyperplasia, 17 resolved, 4 showed no change, and 1 advanced to highly atypical hyperplasia. One person with highly atypical hyperplasia reverted to mild atypical hyperplasia. Of 5 subjects with early gastric cardiac cancer without any treatment, 1 became advanced cancer, 1 still stayed in early cancer stage, 3 turned to atypical hyperplasia. Conclusion: 1. The development of early cancer of gastric cardia would proceed through the stages of chronic gastritis, gland atrophy, and atypical hyperplasia. 2. The early cancer and pre-cancer lesions of gastric cardia is reversible, though possessing malignant possibility.

  10. Custom-Made Computer-Aided-Design/Computer-Aided-Manufacturing Biphasic Calcium-Phosphate Scaffold for Augmentation of an Atrophic Mandibular Anterior Ridge

    Directory of Open Access Journals (Sweden)

    Francesco Guido Mangano

    2015-01-01

    Full Text Available This report documents the clinical, radiographic, and histologic outcome of a custom-made computer-aided-design/computer-aided-manufactured (CAD/CAM scaffold used for the alveolar ridge augmentation of a severely atrophic anterior mandible. Computed tomographic (CT images of an atrophic anterior mandible were acquired and modified into a 3-dimensional (3D reconstruction model; this was transferred to a CAD program, where a custom-made scaffold was designed. CAM software generated a set of tool-paths for the manufacture of the scaffold on a computer-numerical-control milling machine into the exact shape of the 3D design. A custom-made scaffold was milled from a synthetic micromacroporous biphasic calcium phosphate (BCP block. The scaffold closely matched the shape of the defect: this helped to reduce the time for the surgery and contributed to good healing. One year later, newly formed and well-integrated bone was clinically available, and two implants (AnyRidge, MegaGen, Gyeongbuk, South Korea were placed. The histologic samples retrieved from the implant sites revealed compact mature bone undergoing remodelling, marrow spaces, and newly formed trabecular bone surrounded by residual BCP particles. This study demonstrates that custom-made scaffolds can be fabricated by combining CT scans and CAD/CAM techniques. Further studies on a larger sample of patients are needed to confirm these results.

  11. ETHNIC AND POPULATION-SPECIFIC FEATURES OF SOME IMMUNOLOGICAL PARAMETERS IN CHRONIC HELICOBACTER PYLORI INFECTION

    Directory of Open Access Journals (Sweden)

    E. S. Ageeva

    2012-01-01

    Full Text Available Abstract. Immunophenotype profile of lymphocytes (CD3+, CD4+ and CD8+ from peripheral blood in gastric ulcer associated with Helicobacter pylori, chronic gastritis and stomach cancer has been studied in Khakassian aboriginals and migrants. Apoptosis of peripheral blood lymphocytes was also evaluated. Some alterations of immunological indexes were revealed in patients infected with Helicobacter pylori, as compared to healthy donors and migrants. The changes were characterized by a more intense apoptotic death of lymphocytes in the patients, when compared with numbers of apoptotic cells in control group. Probable role of apoptotic events in regulation of local and system immunity in Helicobacter pylori infection is discussed.

  12. A comparative study of toluidine blue-mediated photodynamic therapy versus topical corticosteroids in the treatment of erosive-atrophic oral lichen planus: a randomized clinical controlled trial.

    Science.gov (United States)

    Jajarm, Hasan Hoseinpour; Falaki, Farnaz; Sanatkhani, Majid; Ahmadzadeh, Meysam; Ahrari, Farzaneh; Shafaee, Hooman

    2015-07-01

    Recently, photodynamic therapy (PDT) has been suggested as a new treatment option that is free from side effects for erosive-atrophic oral lichen planus (OLP). The purpose of this study was to compare the effect of toluidine blue-mediated photodynamic therapy (TB-PDT) with local corticosteroids on treatment of erosive-atrophic OLP. In this randomized clinical trial, 25 patients with keratotic-atrophic-erosive oral lichen planus were allocated randomly into two groups. Group 1 (experimental): topical application of toluidine blue with micropipette was applied, and after 10 min, the patients were treated with a 630-nm GaAlAs laser (power density: 10 mW/cm(2)) during two visits. Group 2 (control) used mouthwash diluted with dexamethasone (tab 0/5 in 5 ml water) for 5 min, and then, it was spat out, and after 30 min, the mouth was rinsed with 30 drops of nystatin 100,000 units for 5 min and again spat out. Demographic data, type, and severity of the lesions and pain were recorded before and after treatment and then at the 1-month follow-up visit. Response rate was defined based on changes in intensity of the lesions and pain. In the experimental and control groups, sign scores of changes significantly reduced after treatment respectively (p = 0.021) and (p = 0.002), but between the two groups, no significant difference was observed (p = 0.72). In the experimental (p = 0.005) and control groups (p = 0.001), the intensity of lesions significantly reduced after treatment and there was a significant difference between the two groups (p = 0.001). The mean amount of improvement in pain was significantly greater in the control group compared with the experimental group (p < 0.001) (α = 0.05). Our study showed that TB-PDT with laser was effective in the management of OLP.

  13. Glycoproteomic analysis of serum from patients with gastric precancerous lesions

    DEFF Research Database (Denmark)

    Gomes, Catarina; Almeida, Andreia; Ferreira, José Alexandre;

    2013-01-01

    Gastric cancer is preceded by a carcinogenesis pathway that includes gastritis caused by Helicobacter pylori infection, chronic atrophic gastritis that may progress to intestinal metaplasia (IM), dysplasia, and ultimately gastric carcinoma of the more common intestinal subtype. The identification...... of glycosylation changes in circulating serum proteins in patients with precursor lesions of gastric cancer is of high interest and represents a source of putative new biomarkers for early diagnosis and intervention. This study applies a glycoproteomic approach to identify altered glycoproteins expressing...... the simple mucin-type carbohydrate antigens T and STn in the serum of patients with gastritis, IM (complete and incomplete subtypes), and control healthy individuals. The immunohistochemistry analysis of the gastric mucosa of these patients showed expression of T and STn antigens in gastric lesions, with STn...

  14. Risk Factors of Gastric Cancer in Wuwei City an Endemic Region of Gastric Cancer

    Institute of Scientific and Technical Information of China (English)

    Denghai Mi; Chengyu Su; Haozeng Luo; Jilin Yi; Tianzhong Jing; Qing Xu; Wangsheng Yang; Guoquan Yang; Shuzhen Wang; Gonghan Liu

    2005-01-01

    OBJECTIVE Studies have shown that risk factors of gastric cancer include living habits, eating moldy pickled food, dystrophy, lack of nutrients, and genetics, etc. This study explores the prevalence of these factors in Wuwei, a city in northwest China with a high incidence of gastric cancer.METHODS Family histories of the residents in Wuwei City were investigated with a case-control method. Segregation ratio and heredity degree of gastric cancer were calculated using theLi-Mantel-Cart and Falconer's regression methods. Chronic gastritis patients were followed-up by home visits, gastroscopy, and pathology. Carcinogenic fungi and volatilile N-nitroso compounds were noted in the residents' meals. Helicobactor pylori (Hp) was assessed in their gastric mucosa and the total content of serum vitamin C in 293 healthy adults was determined.RESULTS In Wuwei City, the segregation ratio of gastric cancer was 0.077. The heredity degree of first-degree relatives was 22.91%. The incidence rate of cancer per year in people in an atrophic gastritis group was 1.09%. Eight kinds of nitrosamines and 14 kinds of carcinogenic fungi were detected in the residents' food. Total average vitamin C in the serum of the 293 healthy adults in the summer was 5.74±2.79 mg/L. The positive rate of Hp in gastric mucosa of the residents was 67%.CONCLUSION The majorextrinsic factors include infection of Hp, atrophic gastritis (especially atrophic hyperplasia), and genetic susceptibility.

  15. Double-blind clinical, endoscopic and histological comparison of hydrotalcite/dimethicone suspension and magnesium hydroxide/aluminum hydroxide suspension in the treatment of symptomatic gastritis.

    Science.gov (United States)

    Cobden, I; McMahon, M J; Dixon, M F; Axon, A T

    1981-01-01

    A double-blind, randomized trial was undertaken to compare the clinical, endoscopic and histological response to 6-weeks' treatment with hydrotalcite/dimethicone suspension or magnesium hydroxide/aluminum hydroxide suspension in 36 patients with symptomatic gastritis. Significantly more patients (P less than 0.05) showed symptomatic improvement in the antacid-treated group than in the hydrotalcite/dimethicone-treated group and more had a reduction in histological inflammatory scores (P less than 0.01), although there was little correlation between histology and symptoms. There was no evidence from this study that the bile acid binding and anti-foaming properties of hydrotalcite/dimethicone suspension were of any benefit in the treatment of patients with symptomatic gastritis. PMID:7267678

  16. Efficacy of punch elevation combined with fractional carbon dioxide laser resurfacing in facial atrophic acne scarring: A randomized split-face clinical study

    Directory of Open Access Journals (Sweden)

    Gita Faghihi

    2015-01-01

    Full Text Available Background: A number of treatments for reducing the appearance of acne scars are available, but general guidelines for optimizing acne scar treatment do not exist. The aim of this study was to compare the clinical effectiveness and side effects of fractional carbon dioxide (CO 2 laser resurfacing combined with punch elevation with fractional CO 2 laser resurfacing alone in the treatment of atrophic acne scars. Materials and Methods: Forty-two Iranian subjects (age range 18-55 with Fitzpatrick skin types III to IV and moderate to severe atrophic acne scars on both cheeks received randomized split-face treatments: One side received fractional CO 2 laser treatment and the other received one session of punch elevation combined with two sessions of laser fractional CO 2 laser treatment, separated by an interval of 1 month. Two dermatologists independently evaluated improvement in acne scars 4 and 16 weeks after the last treatment. Side effects were also recorded after each treatment. Results: The mean ± SD age of patients was 23.4 ± 2.6 years. Clinical improvement of facial acne scarring was assessed by two dermatologists blinded to treatment conditions. No significant difference in evaluation was observed 1 month after treatment (P = 0.56. Their evaluation found that fractional CO 2 laser treatment combined with punch elevation had greater efficacy than that with fractional CO 2 laser treatment alone, assessed 4 months after treatment (P = 0.02. Among all side effects, coagulated crust formation and pruritus at day 3 after fractional CO 2 laser treatment was significant on both treatment sides (P < 0.05. Conclusion: Concurrent use of fractional laser skin resurfacing with punch elevation offers a safe and effective approach for the treatment of acne scarring.

  17. INDUCTION OF GASTRIC INTRAEPITHELIAL NEOPLASIA OF GLANDULAR STOMACH OF MONGOLIAN GERBILS BY ELICOBACTER PYLORI

    Institute of Scientific and Technical Information of China (English)

    ZHOU Pin; GU Lian-kun; ZHOU Jing; WANG Ru-ming; ZHAO Zi-hou; DENG Da-jun

    2005-01-01

    Objective: To setup an animal model of gastric carcinogenesis by Helicobacter pylori (Hp) for basic, prevention and therapeutic research of Hp-related diseases. Methods: 22 young male Mongolian gerbils were administrated with suspension of Hp strain TN2 by intragastric gavage for 5 consecutive times (4×108 CFU/time, 1 time/4 days). 10 male gerbils were used as negative control. Two infected gerbils were killed at 10, 20, and 30 weeks, respectively, after inoculation to monitor the development of gastric lesions. Other animals were killed at 40 experimental weeks.Pathological changes of glandular stomach were examined histologically. Results: Gastric intraepithelial neoplasias (GIN) and low-grade dysplasias were observed only in the pyloric antrum of Hp-treated gerbils (3 and 2 ones,respectively), but not in control group (5/13 vs. 0/10, P<0.04). High incidence of chronic active gastritis and chronic atrophic gastritis were observed in Hp-treated animals (10/13, 76.9%). Low incidence of chronic atrophic gastritis was also detected in negative control gerbils (3/10, 30%; P<0.04). Conclusion: Hp inoculation could induce chronic inflammation and malignant lesions of the glandular stomach of Mongolian gerbils conveniently.

  18. Gastrin-releasing peptide receptor antagonist or N-acetylcysteine combined with omeprazol protect against mitochondrial complex II inhibition in a rat model of gastritis.

    Science.gov (United States)

    Rezin, Gislaine T; Petronilho, Fabricia C; Araújo, João H; Gonçalves, Cinara L; Daufenbach, Juliana F; Cardoso, Mariane R; Roesler, Rafael; Schwartsmann, Gilberto; Dal-Pizzol, Felipe; Streck, Emilio L

    2011-03-01

    The pathophysiology of gastritis involves an imbalance between gastric acid attack and mucosal defence. In addition, the gastric mucosal injury results in adenosine triphosphate (ATP) depletion leading to mitochondrial dysfunction. Several studies have shown the association of mitochondrial disorders with gastrointestinal dysfunction. In the present study, we investigated the activity of mitochondrial respiratory chain complexes activity in the stomach of rats with gastritis induced by indomethacin (IDM) and treated with omeprazole (OM), N-acetylcysteine (NAC) and the gastrin-releasing peptide receptor (GRPR) antagonist RC-3095. Adult male Wistar rats were pre-treated for 7 days with OM, NAC, RC-3095, combination of OM plus RC-3095, OM plus NAC and water (control). The animals were then submitted to fasting for 24 hr; IDM was administered. The rats were killed 6 hr later, and the stomachs were used for evaluation of macroscopic damage and respiratory chain activity. Our results showed that complex I and IV activities were not affected by administration of IDM. On the other hand, complex II and III activities were inhibited. In addition, OM plus RC-3095 and OM plus NAC did not reverse complex II activity inhibition. However, the complex III activity inhibition was reversed only with the combined use of OM plus RC-3095 and OM plus NAC. Our results are in agreement with previous studies indicating mitochondrial dysfunction in the pathophysiology of gastrointestinal tract disease and we suggest that GRPR antagonism might be a novel therapeutic strategy in gastritis. PMID:21138529

  19. Efecto de la bebida gasificada en la pared gástrica de ratas macho con gastritis inducida por ácido acetilsalicílico

    Directory of Open Access Journals (Sweden)

    Alejandro Martinez

    2012-09-01

    Full Text Available Objetivo: Evaluar el efecto del consumo prolongado de una bebida gasificada sobre la pared gástrica de ratas con gastritis inducida por ácido acetilsalicílico. Diseño: Estudio experimental  Participantes: ratas macho de 3,5 meses de edad Intervenciones: Se indujo gastritis mediante la administración oral diaria de 300 mg/kg de ácido acetilsalicílico, en solución con agua (grupo control o bebida gasificada (grupo experimental. Luego de tres semanas se evaluaron las alteraciones histopatológicas sobre la pared gástrica. Principales resultados: Se utilizó la Puntuación de Lapa modificada para el análisis macroscópico, comparándose los resultados mediante la Prueba U de Mann-Whitney (p<0,05. Se midió la profundidad de las lesiones microscópicamente, analizándose los resultados con la Prueba T de Student bilateral (p<0,05. Resultados: En ambos casos, las diferencias fueron estadísticamente significativas (p=0,009 y p<0,001, respectivamente, encontrándose lesiones de mayor magnitud en el grupo experimental. Conclusiones: El consumo prolongado de bebida gasificada tiene un efecto agravante del daño producido en la pared gástrica de ratas con gastritis inducida por ácido acetilsalicílico.

  20. A convenient model of severe, high incidence autoimmune gastritis caused by polyclonal effector T cells and without perturbation of regulatory T cells.

    Directory of Open Access Journals (Sweden)

    Eric Tu

    Full Text Available Autoimmune gastritis results from the breakdown of T cell tolerance to the gastric H(+/K(+ ATPase. The gastric H(+/K(+ ATPase is responsible for the acidification of gastric juice and consists of an α subunit (H/Kα and a β subunit (H/Kβ. Here we show that CD4(+ T cells from H/Kα-deficient mice (H/Kα(-/- are highly pathogenic and autoimmune gastritis can be induced in sublethally irradiated wildtype mice by adoptive transfer of unfractionated CD4(+ T cells from H/Kα(-/- mice. All recipient mice consistently developed the most severe form of autoimmune gastritis 8 weeks after the transfer, featuring hypertrophy of the gastric mucosa, complete depletion of the parietal and zymogenic cells, and presence of autoantibodies to H(+/K(+ ATPase in the serum. Furthermore, we demonstrated that the disease significantly affected stomach weight and stomach pH of recipient mice. Depletion of parietal cells in this disease model required the presence of both H/Kα and H/Kβ since transfer of H/Kα(-/- CD4(+ T cells did not result in depletion of parietal cells in H/Kα(-/- or H/Kβ(-/- recipient mice. The consistency of disease severity, the use of polyclonal T cells and a specific T cell response to the gastric autoantigen make this an ideal disease model for the study of many aspects of organ-specific autoimmunity including prevention and treatment of the disease.

  1. Morphological and Cellular Features of Innate Immune Reaction in Helicobacter pylori Gastritis: A Brief Review

    Directory of Open Access Journals (Sweden)

    Antonio Ieni

    2016-01-01

    Full Text Available Innate and adaptive immunity are both involved in acute and chronic inflammatory processes. The main cellular players in the innate immune system are macrophages, mast cells, dendritic cells, neutrophils, eosinophils, and natural killer (NK, which offer antigen-independent defense against infection. Helicobacter pylori (H. pylori infection presents peculiar characteristics in gastric mucosa infrequently occurring in other organs; its gastric colonization determines a causal role in both gastric carcinomas and mucosa-associated lymphoid tissue lymphoma. In contrast, an active role for Epstein-Barr virus (EBV has been identified only in 9% of gastric carcinomas. The aim of the present review is to discuss the role of cellular morphological effectors in innate immunity during H. pylori infection and gastric carcinogenesis.

  2. Morphological and Cellular Features of Innate Immune Reaction in Helicobacter pylori Gastritis: A Brief Review.

    Science.gov (United States)

    Ieni, Antonio; Barresi, Valeria; Rigoli, Luciana; Fedele, Francesco; Tuccari, Giovanni; Caruso, Rosario Alberto

    2016-01-15

    Innate and adaptive immunity are both involved in acute and chronic inflammatory processes. The main cellular players in the innate immune system are macrophages, mast cells, dendritic cells, neutrophils, eosinophils, and natural killer (NK), which offer antigen-independent defense against infection. Helicobacter pylori (H. pylori) infection presents peculiar characteristics in gastric mucosa infrequently occurring in other organs; its gastric colonization determines a causal role in both gastric carcinomas and mucosa-associated lymphoid tissue lymphoma. In contrast, an active role for Epstein-Barr virus (EBV) has been identified only in 9% of gastric carcinomas. The aim of the present review is to discuss the role of cellular morphological effectors in innate immunity during H. pylori infection and gastric carcinogenesis.

  3. [Chronicity, chronicization, systematization of delusions].

    Science.gov (United States)

    Trapet, P; Fernandez, C; Galtier, M C; Gisselmann, A

    1984-05-01

    Chronicity in psychopathology is indicative of a term, a decay. Chronicization only leads the way to this term. Here, chronicization is taken literally as an inscription in the time course of delusions. The mechanism of systematization seems to be a central mark in the approach to chronic delusions. It is not an alienation or an irreversible closing but an attempted accommodation with reality in the life of psychotic subjects, irrespective of the delusional structure. The role of therapy and drug treatment as a follow-up may in that case assume another meaning.

  4. Campylobacter pylori-associated gastritis: attempts to eradicate the bacteria by various antibiotics and anti-ulcer regimens.

    Science.gov (United States)

    Glupczynski, Y; Burette, A; Nyst, J F; De Prez, C; De Koster, E; Deltenre, M

    1988-01-01

    The efficacy of various antimicrobial and anti-ulcer agents on the eradication of Campylobacter pylori in patients with antral gastritis or duodenal ulcers was investigated by several open studies or double-blind, placebo-controlled protocols. Among the anti-ulcer agents, ranitidine, cimetidine or sucraflate had no effect on C. pylori. Colloidal bismuth subcitrate achieved clearance of C. pylori in 40% of treated patients at the end of therapy but a high relapse rate (14/16 patients) was observed after a 6-month follow-up period. The antibacterial agents doxycycline, minocycline, ofloxacin, clindamycin, paromomycin and nifuroxazide failed to eradicate C. pylori in most patients. By contrast, short term elimination of C. pylori could be achieved in more than 90% of patients treated with amoxycillin. However, relapse occurred as a rule in all amoxycillin-treated patients within one month after therapy. Overall, we observed no correlation between the in-vitro activity of the different antibacterial agents and their in vivo efficacy. Development of resistance during therapy does not seem to account for this discrepancy since it occurred only with ofloxacin. On the basis of these results, we conclude that long term eradication of C. pylori from the gastric antrum cannot be achieved after monotherapy either with antibiotics or with bismuth salts. PMID:2979039

  5. Red wine and green tea reduce H pylori- or VacA-induced gastritis in a mouse model

    Institute of Scientific and Technical Information of China (English)

    Paolo Ruggiero; Giacomo Rossi; Francesco Tombola; Laura Pancotto; Laura Lauretti; Giuseppe Del Giudice; Mario Zoratti

    2007-01-01

    AIM: To investigate whether red wine and green tea could exert anti-H pylori or anti-VacA activity in vivo in a mouse model of experimental infection.METHODS: Ethanol-free red wine and green tea concentrates were administered orally as a mixture of the two beverages to H pylori infected mice, or separately to VacA-treated mice. Gastric colonization and gastric inflammation were quantified by microbiological,histopathological, and immunohistochemical analyses.RESULTS: In H pylori-infected mice, the red wine and green tea mixture significantly prevented gastritis and limited the localization of bacteria and VacA to the surface of the gastric epithelium. Similarly, both beverages significantly prevented gastric epithelium damage in VacA-treated mice; green tea, but not red wine, also altered the VacA localization in the gastric epithelium.CONCLUSION: Red wine and green tea are able to prevent H pylori-induced gastric epithelium damage,possibly involving VacA inhibition. This observation supports the possible relevance of diet on the pathological outcome of H pylori infection.

  6. Gene distribution of cagⅡ in Helicobacter pylori-infected patients of Zhejiang Province

    Institute of Scientific and Technical Information of China (English)

    Hai-Yan Liu; Ping-Chu Fang; Yun-Shui Jiang; Ran Tao; Jin Chen

    2004-01-01

    AIM: To determine the prevalence of genotypes of cagⅡin Helicobacter pylori ( H pylori)-infected patients in Zhejiang Province and investigate the relationship between these genotypes and the types of gastroduodenal diseases.METHODS: One hundred and seventy one clinical isolates were collected from 70 chronic superficial gastritis, 31 chronic atrophic gastritis, 41 gastric ulcer, 21 duodenal ulcer, 3 gastric and duodenal ulcer, and 5 gastric adenocarcinoma patients. Polymerase chain reaction assays were performed for analysis of cagT, ORF13 and ORF10 genes in the cagⅡ region.RESULTS: Of 171 Hpyloriisolates from Zhejiang patients,159(93.0%) were positive for all the three loci. One isolate (0.6%) was negative for all the three loci, and 11(6.4%) were partially deleted in cagⅡ. The positive rates of cagT,ORF13and ORF10genes were 97.1%, 94.7% and 99.4%,respectively. In the strains isolated from the patients with diseases including chronic superficial gastritis, chronic atrophic gastritis, gastric ulcer and duodenal ulcer, the sitive rates of cagTwere 95.7%, 100.0%, 95.1% and 100.0%, respectively. The positive rates of ORF13 were 94.3%, 93.5%, 95.1% and 100.0%, respectively. The sitive rates of ORF10 were 98.6%, 100.0%, 100.0% and 100.0%, respectively. The three genes were all positive in the three H pylori strains isolated from the patients with both gastric and duodenal ulcer. In the five strains isolated from the patients with gastric adenocarcinoma,only one isolate was negative for ORF13. There were no significant differences of the cagT, ORF13and ORF10genes among the different gastroduodenal diseases including chronic superficial gastritis, chronic atrophic gastritis,gastric ulcer, duodenal ulcer, both gastric and duodenal ulcer and gastric adenocarcinoma (X2=3.098, P>0.05 for cagT; X2=3.935, P>0.05 for ORF13 and X2=6.328, P>0.05for ORF10).CONCLUSION: The cagⅡis not a uniform and conserved entity. Although the genes in cagⅡ are highly associated

  7. On the Role of Mechanics in Chronic Lung Disease

    Directory of Open Access Journals (Sweden)

    Mona Eskandari

    2013-12-01

    Full Text Available Progressive airflow obstruction is a classical hallmark of chronic lung disease, affecting more than one fourth of the adult population. As the disease progresses, the inner layer of the airway wall grows, folds inwards, and narrows the lumen. The critical failure conditions for airway folding have been studied intensely for idealized circular cross-sections. However, the role of airway branching during this process is unknown. Here, we show that the geometry of the bronchial tree plays a crucial role in chronic airway obstruction and that critical failure conditions vary significantly along a branching airway segment. We perform systematic parametric studies for varying airway cross-sections using a computational model for mucosal thickening based on the theory of finite growth. Our simulations indicate that smaller airways are at a higher risk of narrowing than larger airways and that regions away from a branch narrow more drastically than regions close to a branch. These results agree with clinical observations and could help explain the underlying mechanisms of progressive airway obstruction. Understanding growth-induced instabilities in constrained geometries has immediate biomedical applications beyond asthma and chronic bronchitis in the diagnostics and treatment of chronic gastritis, obstructive sleep apnea and breast cancer.

  8. Is Helicobacter Pylori a Possible Etiopathogenic Factor in Chronic Tonsillitis?

    Directory of Open Access Journals (Sweden)

    Elmas Ozgun

    2014-03-01

    Full Text Available Aim: Helicobacter pylori is the major gastric pathogen which has an important role in the etiopathogenesis of chronic gastritis. We investigated the presence of Helicobacter pylori as an extragastric reservoir in the tonsillectomy specimens to display if it is an etiologic factor in the development of chronic tonsilitis. Material and Method: In the current study, 100 cases with chronic tonsilitis were examined in bilateral tonsillectomy specimens. The colonization of the microorganism have been evaluated with hematoxylin-eosin and giemsa stains under the light microscope.Results: Helicobacter pylori has been detected in 33 cases (33% on one side of the bilateral tonsillectomy specimens while it has been seen in 15 cases (15% on both sides which demonstrated positivity in 48 cases (48% in total. No colonization has been observed in the remaining 52 cases (52%. Discussion: Due to the considerable positivity in our study, the histopathologic evaluation of tonsillary Helicobacter pylori colonization may be instrumental in the etiologic association with chronic tonsillitis.

  9. Characteristics of Clinico-pathologic Presentations of Chronic Gastroduodenitis in Children with Lambliasis Invasion

    Directory of Open Access Journals (Sweden)

    Matveeva O.V.

    2012-03-01

    Full Text Available The analysis of anamnestic and clinical indices, and also morphological investigation of biopsy materials of mucous coat of stomach and duodenum in children with chronic gastroduodenitis of different etiology including lambliasis invasion is carried out with the purpose of detecting features of clinicopathologic presentations of chronic gastroduodenitis in children with and without lambliasis invasion. Material and methods. 100 patients (50 children with confirmed lambliasis invasion and 50 patients without lambliasis invasion aged from 2 up to 16 were under observation. The material for histologic study was received as a result of fibrogastroduodenoscopy carried out with target biopsy of fundic, antrum and duodenum mucosa. Results. As a result of the findings moderate pains sited in epigastric and periumbilical regions are characteristic for children with lambliasis invasion; irradiation and cramping characteristics of pains are typical. Conclusion. Manifestation of pains is not connected with the time of day and food intake, manifestation of seasonal prevalence is not typical as well, and progression of inflammatory process in the mucous coat of the stomach and duodenum is declared itself as a diffuse gastritis of the fundic part, a diffuse gastritis of the antral part, subatrophic duodenitis with cyst formation of Brunner's glands, and also the presence of eosinophilic leucocytes in the cellular infiltrate

  10. [Endoscopical features of precancer changes of the stomach in patients with chronic gastric erosions and biliary tract disease].

    Science.gov (United States)

    Solovĭova, H A

    2012-01-01

    Frequency of the precancer changes of the stomach, diagnosed by using zoom-endoscopy, NBI, chromoscopy, in the three groups of patients: with gastric erosions and biliary tract diseases, with gastric erosions and duodenal ulcer disease, with gastric erosions and chronic gastritis is compared in the article. It is shown, that patients with gastric erosions and biliary tract diseases are characterized by bigger spreading of precancer changes: atrophy, intestinal metaplasia with predominant smalluently intestine in gastric body, intestine metaplasia in antral part of the stomach is revealed more freq in these category of patients. A strong correlation between endoscopical and morphological methods of investigation was demonstrated.

  11. Chronic cholecystitis

    Science.gov (United States)

    ... foods may relieve symptoms in people. However, the benefit of a low-fat diet has not been proven. Alternative Names Cholecystitis - chronic Images Cholecystitis, CT scan Cholecystitis, cholangiogram Cholecystolithiasis Gallstones, cholangiogram Cholecystogram References Wang ...

  12. Chronic Meningitis

    Science.gov (United States)

    ... School Lunch Lines FDA Cracks Down on Antibacterial Soaps Health Tip: Schedule a Back-to-School Dental ... the Professional Version Meningitis Introduction to Meningitis Acute Bacterial Meningitis Viral Meningitis Noninfectious Meningitis Recurrent Meningitis Chronic ...

  13. EXPRESSION OF P16 AND CYCLIN D1 IN THE COURSE OF CARCINOGENESIS OF THE STOMACH

    Institute of Scientific and Technical Information of China (English)

    CHEN Yu-long; XU Feng; LI Yan-jie

    1999-01-01

    Objective: To determine p16 and cyclin D1 expression in the specimen of gastric carcinoma, atypic hyperplasia, atrophic gastritis, superficial gastritis and normal gastric mucosa. Methods: Using immunohistochemical method (ABC), the samples of 58 adenocarcinomas, 22 atypic hyperplasias, 28 atrophic gastritis,27 superficial gastritis and 15 gastric epitheliums were analyzed. Results: Positive immunostaining rate for p16 protein was the highest in normal gastric mucosa and decreased with the lesions progressing from superficial gastritis to atrophic gastritis to atypital hyperplasia and to adenocarcinoma (85%, 78.6%, 31.8%,48.3% respectively); Positive immunostaining of cyclin D1 can observed in atrophic gastritis. With the lesions progressing from atrophic gastritis to atypical hyperplasia to adenocarcinoma, its expression rate increased (17.9%, 36.4%, 53.4% respectively), and there was a significant difference between adenocarcinoma and atrophic gastritis group (P<0.05). An interesting observation was that inverse expression between p16and cyclin D1, was shown in most of gastric cancer detected. Conclusion: It is indicated that p16 and cyclin D1 play an important role in the gastric carcinogenesis, the inverse expression between p16 and cyclin D1 suggested that there is a suppression trend in them.

  14. Expression of mucosal addressin cell adhesion molecule 1 on vascular endothelium of gastric mucosa in patients with nodular gastritis

    Institute of Scientific and Technical Information of China (English)

    Hiroshi Ohara; Takehiko Koji; Hiroshi Nagura; Shigeru Kohno; Hajime Isomoto; Chun-Yang Wen; Chieko Ejima; Masahiro Murata; Masanobu Miyazaki; Fuminao Takeshima; Yohei Mizuta; Ikuo Murata

    2003-01-01

    AIM: The interaction of mucosal addressin cell adhesion molecule 1 (MAdCAM-1) with integrin α4β7 mediates lymphocyte recruitment into mucosa-associated lymphoid tissue (MALT). Nodular gastritis is characterized by a unique military pattern on endoscopy representing increased numbers of lymphoid follicles with germinal center, strongly associated with H pylori infection. The purpose of this study was to address the implication of the MAdCAM-1/integrin β7 pathway in NG.METHODS: We studied 17 patients with NG and H pylori infection and 19 H pylori-positive and 14 H pylori-negative controls. A biopsy sample was taken from the antrum and snap-frozen for immunohistochemical analysis of MAdCAM1 and integrin β7. In simultaneous viewing of serial sections,the percentage of MAdCAM-1-positive to von Willebrand factor-positive vessels was calculated. We also performed immunostaining with anti-CD20, CD4, CD8 and CD68 antibodies to determine the lymphocyte subsets coexpressing integrin β7.RESULTS: Vascular endothelial MAdCAM-1 expression was more enhanced in gastric mucosa with than without H pylori infection. Of note, the percentages of MAdCAM-1-positive vessels were significantly higher in the lamina propria of NG patients than in H pylori-positive controls. Strong expression of MAdCAM-1 was identified adjacent to lymphoid follicles and dense lymphoid aggregates. Integrin β7-expressing mononuclear cells, mainly composed of CD20 and CD4 lymphocytes, were associated with vessels lined with MAdCAM-1-expressing endothelium.CONCLUSION: Our results suggest that the MAdCAM-1/integrin α4β7 homing system may participate in gastric inflammation in response to H pylori-infection and contributes to MALT formation, typically leading to the development of NG.

  15. A case report of collagenous gastritis in a young Chinese woman and literatures review%胶原性胃炎一例并文献复习

    Institute of Scientific and Technical Information of China (English)

    张贺军; 金珠; 林三仁; 丁士刚; 白鹏; 崔荣丽; 韩亚京; 张颖; 尚惠茹

    2010-01-01

    Objective Collagenous gastritis is a rare entity, characterized by the deposition of a subepithelial collagen band with an inflammatory infiltrate in the mucosa.This report describes the first case of collagenous gastritis occurring in a young Chinese woman and reviews the literatures.Methods The patient underwent the gastroscopy screening, and the biopsy specimens were treated with HE staining, Masson staining, Congo red staining and Warthin-Starry staining.Patients' clinical data was discussed and followed up.Results A twenty-year-old girl had intermittent epigastric pain for 4 years, abdominal distention, hiccup and weight loss for two months.The gastric endoscopy revealed diffuse white nodular appearance of the mucosa in angular incisure and antrum.Pathologic examination of the gastric biopsies from the antrum and angular showed a subepithelial collagen deposition with moderate infiltrates of lymphoplasma cells and eosinophils of the lamina propria.The collagen band measured up to 120.3 μm (mean 43.8 μm).Prednisone 20 mg/d for 4 weeks led to clinical remission and weight gain.Conclusion There are about 40 cases in literatures to date, and the cause and pathogenesis of collagenous gastritis remain unknown.According to the clinical and pathological characteristics, the patient in this article is the subtype of collagenous gastritis that occurring in children and young adults.Specific therapy has not been established, the gluten-free diet and glucocorticosteroid may be helpful to relieve symptoms in collagenous gastritis patients.%目的 胶原性胃炎(coHagenous gastritis,CG)临床少见,现报道一例CG并进行文献复习.方法 患者行胃镜检查,活检组织切片分别行HE染色、Masson染色、刚果红染色及Warthin-Starry染色;分析病例临床资料并进行随访.结果 1例20岁女性患者主因无规律上腹痛4年,伴腹胀、呃逆、体重明显下降2个月就诊.胃镜检查于角切迹及窦部可见白色结节(活检).病理

  16. Evaluation of gastric histology in children and adolescents with Helicobacter pylori gastritis using the Update Sydney System Avaliação da histologia gástrica em crianças e adolescentes com gastrite por Helicobacter pylori usando o Sistema de Sydney Atualizado

    Directory of Open Access Journals (Sweden)

    Marini Langner

    2009-12-01

    Full Text Available CONTEXT: Although Helicobacter pylori infection is prevalent in our country, there are few studies evaluating the associated histological abnormalities in children. OBJECTIVE: To evaluate the histological features of the gastric mucosa in children and adolescents with Helicobacter pylori gastritis. METHODS: One hundred and thirty two gastric biopsies from 22 symptomatic patients infected with H. pylori (14F/8M, median age 10 y 5 mo, age range 2 y 11 mo to 16 y 9 mo were evaluated. Evaluated gastric regions included: antrum (lesser and greater curvature, corpus (lesser and greater curvature, incisura angularis and fundus. Histological examination was performed according to the Updated Sydney System, and regional scores for polymorphonuclear and mononuclear cell infiltrate as well as bacterial density were generated. RESULTS: Fifteen (68.2% patients presented H. pylori-chronic active gastritis, six (27.3% presented antrum-predominant H. pylori-chronic active gastritis, and one (4.5% presented corpus-predominant H. pylori-chronic active gastritis. Polymorphonuclear cell infiltrate and mononuclear cell infiltrate were observed in 93.9% and 98.5% of the biopsy specimens, respectively. Higher histological scores for polymorphonuclear infiltrate, mononuclear infiltrate, and bacterial density were observed in the gastric antrum. Intestinal metaplasia and gastric atrophy were not identified in any patient. Lymphoid aggregates and lymphoid follicles were observed in the gastric antrum of three (13.6% and seven (31.8% patients, respectively, but they were not related to antral nodularity. CONCLUSIONS: Chronic active gastritis was observed in all patients with H. pylori infection. However, antral or corporeal predominance was not observed in most patients.CONTEXTO: Embora a infecção por Helicobacter pylori seja prevalente em nosso país, há poucos estudos avaliando a histologia gástrica de crianças infectadas. OBJETIVO: Avaliar as caracter

  17. Mutations in the 180-kD bullous pemphigoid antigen (BPAG2), a hemidesmosomal transmembrane collagen (COL17A1), in generalized atrophic benign epidermolysis bullosa.

    Science.gov (United States)

    McGrath, J A; Gatalica, B; Christiano, A M; Li, K; Owaribe, K; McMillan, J R; Eady, R A; Uitto, J

    1995-09-01

    Junctional epidermolysis bullosa (JEB) is a heterogeneous autosomal recessively inherited blistering skin disorder associated with fragility at the dermal-epidermal junction. Characteristic ultrastructural findings in JEB are abnormalities in the hemidesmosome-anchoring filament complexes. These focal attachment structures, which extend from the intracellular compartment of the basal keratinocytes to the underlying basement membrane, have been shown to be hypoplastic or rudimentary in different forms of JEB. Previously, in different JEB phenotypes, mutations have been found in the three genes for the anchoring filament component laminin 5 (LAMA3, LAMB3, and LAMC2) and in the gene for the hemidesmosome-associated integrin beta 4 subunit. Here, we describe the first mutations in the gene encoding the 180-kD bullous pemphigoid antigen (BPAG2), a transmembranous hemidesmosomal collagen, also known as type XVII collagen (COL17A1). The patient is affected with generalized atrophic benign epidermolysis bullosa (GABEB), a rare variant of JEB, and is a compound heterozygote for premature termination codons on both alleles. These novel findings emphasize the molecular heterogeneity of this group of genodermatoses, and attest to the importance of BPAG2 in maintaining adhesion between the epidermis and the dermis. PMID:7550320

  18. Purification and relationship with gastric disease of a 130 kDa(CagA) protein of Helicobacter pylorl

    Institute of Scientific and Technical Information of China (English)

    叶少菁; 方平楚; 毛国根; 厉朝龙; 丘翔; 陈海洋

    2003-01-01

    Objective:The aims of this research were to purify and identify the 130 kDa(CagA) protein of H.pylori clinical isolate HP97002 and evaluate the relationships between the purified 130 kDa(CagA) pro-tein and gastric diseases.Methods:The procedure for isolating the protein included 6 mol/L guanidine ex-tract,size exclusion chromatography and elusion from gel.Sera of 68 patients with gastric diseases(44 with chronic gastritis,15 with atrophic gastritis,7 with peptic ulcer disease,2 with gastric cancer) were obtained,and the serological response to CagA was studied by Westem-blot using the purified protein,Results;The pu-rified protein was 130 kDa and preserved good antigenicity and revealed basic isoelectric point about of 8.1. Among 68 sera,43 sera could recognize the purified protein associated with chronic agastritis 47.7%(21/44),atrophic gastritis 86.7%(13/15),peptic ulcer disease 100%(7/7),gastric cancer 100%(2/2).Compared with each other,the difference was significant(x2=13.327,P=0.004),and 130 kDa(CagA) protein was associated with severe gastric diseases(rs=0.442,P=0.001).Conclusion:The 130 kDa(CagA) protein was associated wih severe gastric diseases.

  19. Chronic myelogenous leukemia (CML)

    Science.gov (United States)

    CML; Chronic myeloid leukemia; Chronic granulocytic leukemia; Leukemia - chronic granulocytic ... nuclear disaster. It takes many years to develop leukemia from radiation exposure. Most people treated for cancer ...

  20. Chronic obstructive pulmonary disease

    Science.gov (United States)

    ... airways disease; Chronic obstructive lung disease; Chronic bronchitis; Emphysema; Bronchitis - chronic ... a protein called alpha-1 antitrypsin can develop emphysema. Other risk factors for COPD are: Exposure to ...

  1. Phlegmonous gastritis: a rare entity as a differential diagnostic of an acute abdomen. Description of a case and a bibliographic review

    Directory of Open Access Journals (Sweden)

    Arantzazu Rada-Palomino

    2014-06-01

    Full Text Available Phlegmonous gastritis is a rare bacterial infection of the gastric wall, which progress rapidly. It is characterized by a purulent inflammation that can affect the entire gastrointestinal tract and presents a high mortality rate. We are reporting a case of phlegmonous gastritis in an HIV-seropositive man successfully treated with antibiotics. Moreover, a review of the English and Spanish literature is carried out, from 1980 to the present time. The most frequently involved microorganism is Streptococcus spp. (57 %, but the polimicrobial infection is also frequent (17 %. The most important symptom is the intensive epigastric pain associated with vomits and most cases were diagnosed by CT and/or fibrogastroscopy. There are many existing risk factors described. The main one is the immunesuppression, although in 40 % of the cases no risk factors were identified. The global mortality is 27 % without identifying significant differences between antibiotics and surgical treatment, for that reason it is recommended to initiate antibiotic treatment right from the beginning and postponing surgery for the refractory cases and complications.

  2. Chronic pain - resources

    Science.gov (United States)

    Pain - resources; Resources - chronic pain ... The following organizations are good resources for information on chronic pain: American Chronic Pain Association -- www.theacpa.org National Fibromyalgia and Chronic Pain Association -- www.fmcpaware.org ...

  3. Low back pain - chronic

    Science.gov (United States)

    Nonspecific back pain; Backache - chronic; Lumbar pain - chronic; Pain - back - chronic; Chronic back pain - low ... Low back pain is common. Almost everyone has back pain at some time in their life. Often, the exact cause ...

  4. Chronic motor tic disorder

    Science.gov (United States)

    Chronic vocal tic disorder; Tic - chronic motor tic disorder ... Chronic motor tic disorder is more common than Tourette syndrome . Chronic tics may be forms of Tourette syndrome. Tics usually start ...

  5. Chronic Pelvic Pain

    Science.gov (United States)

    ... Events Advocacy For Patients About ACOG Chronic Pelvic Pain Home For Patients Search FAQs Chronic Pelvic Pain ... Pain FAQ099, August 2011 PDF Format Chronic Pelvic Pain Gynecologic Problems What is chronic pelvic pain? What ...

  6. Employees with Chronic Pain

    Science.gov (United States)

    ... Home | Accommodation and Compliance Series: Employees with Chronic Pain By Beth Loy, Ph.D. Preface Introduction Information ... at http://AskJAN.org/soar. Information about Chronic Pain How prevalent is chronic pain? Chronic pain has ...

  7. Cloning of the human type XVII collagen gene (COL17A1), and detection of novel mutations in generalized atrophic benign epidermolysis bullosa

    Energy Technology Data Exchange (ETDEWEB)

    Gatalica, B.; Pulkkinen, L.; Li, K. [Thomas Jefferson Univ., Philadelphia, PA (United States)] [and others

    1997-02-01

    Generalized atrophic benign epidermolysis bullosa (GABEB) is a nonlethal variant of junctional epidermolysis bullosa (JEB). Previous findings have suggested that type XVII collagen is the candidate gene for mutations in this disease. We now have cloned the entire human type XVII collagen gene (COL17A1) and have elucidated its intron-exon organization. The gene comprises 56 distinct exons, which span {approximately}52 kb of the genome, on the long arm of chromosome 10. It encodes a polypeptide, the {alpha}1(XVII) chain, consisting of an intracellular globular domain, a transmembrane segment, and an extracellular domain that contains 15 separate collagenous subdomains, the largest consisting of 242 amino acids. We also have developed a strategy to identify mutations in COL17A1 by use of PCR amplification of genomic DNA, using primers placed on the flanking introns. The PCR products are scanned for sequence variants by heteroduplex analysis using conformation-sensitive gel electrophoresis and then are subjected to direct automated sequencing. We have identified several intragenic polymorphisms in COL17A1, as well as mutations, in both alleles, in two Finnish families with GABEB. The probands in both families showed negative immunofluorescence staining with an anti-type XVII collagen antibody. In one family, the proband was homozygous for a 5-bp deletion, 2944del5, which resulted in frameshift and a premature termination codon of translation. The proband in the other family was a compound heterozygote, with one allele containing the 2944del5 mutation and the other containing a nonsense mutation, Q1023X. These results expand the mutation database in different variants of JEB, and they attest to the functional importance of type XVII collagen as a transmembrane component of the hemidesmosomes at the dermal/epidermal junction. 48 refs., 9 figs., 3 tabs.

  8. Chronic coughing

    International Nuclear Information System (INIS)

    Chronic coughing was acknowledged to result from pathological state of the respiratory organs. Cardiac diseases could be accompanied by coughing as well. It was recommended to perform x-ray examinations, including biomedical radiography of the chest, computerized tomography, scintiscanning with 67Ga-citrate, bronchi examination in order to exclude heart disease. The complex examination permitted to detect localization and type of the changes in the lungs and mediastinum, to distinguish benign tumor from malignant one

  9. Mineral Requirements in Children with Chronic Liver Disease

    Directory of Open Access Journals (Sweden)

    A Rezaeian

    2014-04-01

    Full Text Available Introduction: Decreased oral intake or impaired function / structure in the gut, such as hypertension port associated with atrophic changes in the protein nutrition - calories can lead to micronutrient deficiencies.This paper examines the status of micronutrients in chronic liver disease in children.   Materials and Methods: In this review study databases including proquest, pubmedcentral, scincedirect, ovid, medlineplus were been searched with keyword words such as” chronic liver disease"” minerals””children” between 1999 to 2014. Finally, 3 related articles have been found.   Results: In chronic liver disease changes in micronutrient metabolism lead to changes in the daily requirements, such that in certain circumstances intake increasing or decreasing  is needed. Low serum calcium and phosphate concentrations are often the reflection of malabsorption-induced bone disease that is unresponsive to vitamin D store normalization. Iron is usually deficient in children with CLD and supplementation frequently needed. The origin of iron deficiency is multifactorial and includes ongoing losses, inadequate intakes, serial blood draws and malabsorption secondary to hypertensive enteropathy. Zinc plays an important role in cognitive function, appetite and taste, immune function, wound healing, and protein metabolism. Low plasma zinc levels are frequent in children with chronic cholestasis, but unfortunately plasma concentrations are not reflective of total body zinc status. Copper and manganese, unlike other minerals, are increased in CLD, because they are normally excreted through bile. Parenteral nutrition in cholestatic patients can induce manganese intoxication and accumulation in basal ganglia.   Conclusion:  In fants with CLD are prone to multiple nutritional deficiencies. Mineral state should be evaluated, treated and reevaluated, until sufficient daily requirement achieved. Poster  Presentation, N 33  

  10. Photoshop评价激光治疗痤疮凹陷性瘢痕疗效的探索%Explore of evaluting method by Photoshop on the therapeutic effect of atrophic acne with laser

    Institute of Scientific and Technical Information of China (English)

    吴琰瑜; 章伟; 王娜; 徐晓云

    2012-01-01

    目的:探索Photoshop在点阵Er:YAG激光治疗痤疮凹陷性瘢痕疗效分析中应用的可行性.方法:将点阵Er:YAG激光治疗痤疮凹陷性瘢痕患者的术前、术后照片输入计算机,并用Photoshop CS5对每例患者正常部位及凹陷性瘢痕部位进行灰度值计算,然后计算激光术前灰度值差异率、激光术后灰度值差异率及凹陷性瘢痕改善率.结果:①激光术后灰度值差异率小于激光术前灰度值差异率,两组之间差异有显著性(P<0.05);②随着视觉评分的增高,凹陷性瘢痕灰度值改善率增加,评分为1分、2分组与评分为3分、4分组之间差异有显著性(P<0.05);③激光治疗次数为3次及3次以上组与治疗次数为2次及2次以下组凹陷性瘢痕灰度值改善率分别为3.3%及1.6%,但两组之间无显著性差异(P>0.05).结论:①Photoshop可以作为痤疮凹陷性瘢痕疗效性评价的客观评价方法;②点阵Er:YAG激光治疗痤疮凹陷性瘢痕有效.%Objective To explore the feasibility of Photoshop being used in evaluating the therapeutic effect of atrophic acne scar by fractional Er:YAG laser. Methods Input the picture of atrophic acne scar of patient of postoperation and preoperation, then calculate the gray value of normal skin and atrophic acne scar by Photoshop CS5, and then calculate the ratio of difference of gray value of postoperation, ratio of difference of gray value of postoperation and Ratio of improvement of atrophic acne scar. Results ①Ratio of difference of gray value of postoperation was significantly lower than that of preoperation (P0.05). Conclusion ①Photoshop can be used as an objective method for evaluating the therapeutic effect of atrophic acne scar by fractional ErYAG laser;②Fractional Er:YAG laser was effective for the treatment of atrophic acne scar.

  11. Tilted and bicortical placement of implants for the extremely atrophic posterior mandible%双皮质骨种植在下颌后牙区萎缩牙槽骨中的应用

    Institute of Scientific and Technical Information of China (English)

    蒋志平; 陈鹏; 周鑫才; 贺正华; 曹颖光

    2012-01-01

    目的:评价双皮质骨种植应用于下颌后牙区萎缩牙槽骨的临床效果.方法:15例下颌磨牙区牙槽骨中重度萎缩病例,倾斜双皮质骨植入22枚种植体,随访2年,行X线片、问卷调查等随访.结果:第1年骨丧失为(0.635±0.139)mm,第2年骨丧失为(0.141±0.032) mm:15名患者均没有疼痛不适、口唇麻木或感觉减退,满意率达93%.结论:双皮质骨种植应用于下颌后牙区萎缩牙槽骨取得了满意的治疗效果.%Objective: To evaluate the treatment outcomes of tilted and bicortical placement of implants for the extremely atrophic posterior mandible. Method: A total of IS patients with the extremely atrophic posterior mandible received 22 tilted implants. All patients were questioned for painnumb. paresthesia and satisfaction. Clinical parameters including x-ray examinations, inflammation.occlusioni etc were obtained and accessed in 2 years of follow-up. Result: The bone loss was (0.635±0.1.39)mm in the first year and (0.141 ±0.032)mm in the second year. All patients were not pain,numb and parea-thesia. Ninety-three percent of patients were satisfied with the treatment. Conclusion: Tilled and bicortical placement of implants was successful for the extremely atrophic posterior mandible and achieved the excellent outcomes of the present study.

  12. Total pancreatectomy for the treatment of chronic pancreatitis: indications, outcomes, and recommendations.

    Science.gov (United States)

    Behrman, Stephen W; Mulloy, Matthew

    2006-04-01

    Total pancreatectomy (TP) for chronic pancreatitis (CP) has not gained widespread acceptance because of concerns regarding technical complexity, diabetic complications, and uncertainty with respect to long-term pain relief. Records of patients having TP from 1997 to 2005 were reviewed. Patient presentation, etiology of disease, and the indication for TP were examined. Operative results were analyzed. Long-term results were critically assessed, including narcotic usage and the need for re-admission. Postoperative quality of life (QOL) was assessed by the SF-36 health survey. During the study period, 7 patients with CP had TP, and 28 had other operations. The etiology of CP was alcohol in four and hereditary pancreatitis in three. The indication for surgery was pain and weight loss. Preoperatively, all patients used narcotics chronically and two had insulin-dependent diabetes. Four had TP after failed previous surgical procedures. Endoscopic retrograde cholangiopancreatography and computed tomography demonstrated small ducts and atrophic calcified glands. The mean length of the operation was 468 minutes, and only two patients required transfusion. There were no biliary anastomotic complications. The mean length of stay was 14 days. Major morbidity was limited to a single patient with a leak from the gastrojejunal anastomosis. Thirty-day mortality was zero, with one late death unrelated to the surgical procedure or diabetes. The mean length of follow-up was 46 months. All patients remained alcohol and narcotic free. No patient was readmitted with a diabetic complication. When compared with the general population, QOL scores were diminished but reasonable. We conclude that TP is indicated in hereditary pancreatitis and in those with an atrophic, calcified pancreas with small duct disease; that TP is technically arduous but can be completed with very low morbidity and mortality; and that on long-term follow-up, pain relief and abstinence from alcohol and narcotics was

  13. Chronic Insomnia

    OpenAIRE

    Buysse, Daniel J.

    2008-01-01

    Ms. F, a 42-year-old divorced woman, presents for evaluation of chronic insomnia. She complains of difficulty falling asleep, often 30 minutes or longer, and difficulty maintaining sleep during the night, with frequent awakenings that often last 30 minutes or longer. These symptoms occur nearly every night, with only one or two “good” nights per month. She typically goes to bed around 10:00 p.m. to give herself adequate time for sleep, and she gets out of bed around 7:00 a.m. on work days and...

  14. Cholesterolosis and chronic cholecystitis: comperative analysis of state of gall-bladder wall.

    Directory of Open Access Journals (Sweden)

    Shcherbinina M.B.

    2007-01-01

    Full Text Available The mechanisms of lipid infiltration of gall-bladder (GB wall in case of cholesterolosis are not known now. The aim of this work was studying the morphologic peculiarities of forming cholesterolosis comparing with state of chronic cholecystitis by anatomical parts of GB using system stereometric analysis. There was performed the histological examination of 2 groups of GB removed by standart laparoscopic cholecystectomy due to cholecystolithiasis. The first group contains GB with diffuse reticular form of cholesterolosis (n=28, the second group contains GB with chronic inflammation without signs of activation (n=21. Using G.G.Avtandilov’s recommendations there were determined the volume interrelations of stroma and epithelium (stromal-epithelial index, cellular content of lamina propria of GB mucosa (neutrophyles, eosinophyles, lymphocytes, plasmocytes, xantom cells, lymphocytes-plasmocytes index. The results were evaluated by t-criterion of Student, changes were statistically evident if р<0,05. There was also used the correlative analysis with estimation of correlation coefficient t. There was established that in case of GB cholesterlolsis the morphologic changes in GB wall had dystrophic character and might accompany with not marked sclerotic changes in mucosa. In case of chronic cholecystitis the inflammatory process lead to atrophic-sclerotic changes. In case of cholecystolithiasis with diffuse reticular form of GB cholesterolosis or chronic cholecystitis the prevalent localization of pathology is corpus and fundus of organ.

  15. Retinal Spectral Domain Optical Coherence Tomography in Early Atrophic Age-Related Macular Degeneration (AMD and a New Metric for Objective Evaluation of the Efficacy of Ocular Nutrition

    Directory of Open Access Journals (Sweden)

    Stuart Richer

    2012-11-01

    Full Text Available Purpose: A challenge in ocular preventive medicine is identification of patients with early pathological retinal damage that might benefit from nutritional intervention. The purpose of this study is to evaluate retinal thinning (RT in early atrophic age-related macular degeneration (AMD against visual function data from the Zeaxanthin and Visual Function (ZVF randomized double masked placebo controlled clinical trial (FDA IND #78973. Methods: Retrospective, observational case series of medical center veterans with minimal visible AMD retinopathy (AREDS Report #18 simplified grading 1.4/4.0 bilateral retinopathy. Foveal and extra-foveal four quadrant SDOCT RT measurements were evaluated in n = 54 clinical and ZVF AMD patients. RT by age was determined and compared to the OptoVue SD OCT normative database. RT by quadrant in a subset of n = 29 ZVF patients was correlated with contrast sensitivity and parafoveal blue cone increment thresholds. Results: Foveal RT in AMD patients and non-AMD patients was preserved with age. Extrafoveal regions, however, showed significant slope differences between AMD patients and non-AMD patients, with the superior and nasal quadrants most vulnerable to retinal thinning (sup quad: −5.5 μm/decade thinning vs. Non-AMD: −1.1 μm/decade, P < 0.02; nasal quad: −5.0 μm/decade thinning vs. Non-AMD: −1.0 μm/decade, P < 0.04. Two measures of extrafoveal visual deterioration were correlated: A significant inverse correlation between % RT and contrast sensitivity (r = −0.33, P = 0.01, 2 Tailed Paired T and an elevated extrafoveal increment blue cone threshold (r = +0.34, P = 0.01, 2 Tailed T. Additional SD OCT RT data for the non-AMD oldest age group (ages 82–91 is needed to fully substantiate the model. Conclusion: A simple new SD OCT clinical metric called “% extra-foveal RT” correlates well with functional visual loss in early AMD patients having minimal visible retinopathy. This metric can be used to

  16. Fuentes de variabilidad en el diagnóstico de gastritis atrófica multifocal asociada con la infección por Helicobacter pylori1

    Science.gov (United States)

    Bravo, Luis Eduardo; Bravo, Juan Carlos; Realpe, José Luis; Zarama, Guillermo; Piazuelo, MarÍa Blanca; Correa, Pelayo

    2014-01-01

    RESUMEN Introducción El mapeo de las diferentes regiones del estómago y el número de fragmentos de mucosa gástrica disponibles para evaluación histopatológica son fuentes importantes de variación en el momento de clasificar y hacer la gradación de la gastritis crónica. Objetivos Estimar la sensibilidad del número de fragmentos de mucosa gástrica necesarios para establecer los diagnósticos de gastritis atrófica con metaplasia intestinal (MI), displasia y estado de infección por Helicobacter pylori. Además evaluar la variabilidad intra-observador en la clasificación de estas lesiones precursoras del cáncer gástrico. Materiales y métodos En una cohorte de 6 años de seguimiento se evaluaron 1,958 procedimientos de endoscopia realizados por dos gastroenterólogos. En cada procedimiento y de cada participante se obtuvieron 5 biopsias de mucosa gástrica que representaban antro, incisura angularis y cuerpo. Un único patólogo hizo la interpretación histológica de las 5 biopsias y proporcionó un diagnóstico definitivo global que se utilizó como patrón de referencia. Cada fragmento de mucosa gástrica examinado condujo a un diagnóstico individual para cada biopsia que se comparó con el patrón de referencia. La variabilidad intra-observador se evaluó en 127 personas que corresponden a una muestra aleatoria de 20% del total de endoscopias hechas a los 72 meses de seguimiento. Resultados La sensibilidad del diagnóstico de MI y displasia gástrica aumentó de manera significativa con el número de fragmentos de mucosa gástrica evaluados El sitio anatómico de mayor sensibilidad para el diagnóstico de MI y displasia fue la incisura angularis. Para descubrir H. pylori se logró alta sensibilidad con el estudio de un solo fragmento de mucosa gástrica (95.9%) y fue independiente del sitio de obtención de la biopsia. El acuerdo intra-observador para el diagnóstico de gastritis crónica fue 86.1% con valor kappa de 0.79 IC 95% (0.76-0.85). Las

  17. Fuentes de variabilidad en el diagnóstico de gastritis atrófica multifocal asociada con la infección por Helicobacter pylori

    Directory of Open Access Journals (Sweden)

    Luis Eduardo Bravo

    2008-03-01

    Full Text Available Introducción: El mapeo de las diferentes regiones del estómago y el número de fragmentos de mucosa gástrica disponibles para evaluación histopatológica son fuentes importantes de variación en el momento de clasificar y hacer la gradación de la gastritis crónica. Objetivos: Estimar la sensibilidad del número de fragmentos de mucosa gástrica necesarios para establecer los diagnósticos de gastritis atrófica con metaplasia intestinal (MI, displasia y estado de infección por Helicobacter pylori. Además evaluar la variabilidad intra-observador en la clasificación de estas lesiones precursoras del cáncer gástrico. Materiales y métodos: En una cohorte de 6 años de seguimiento se evaluaron 1,958 procedimientos de endoscopia realizados por dos gastroenterólogos. En cada procedimiento y de cada participante se obtuvieron 5 biopsias de mucosa gástrica que representaban antro, incisura angularis y cuerpo. Un único patólogo hizo la interpretación histológica de las 5 biopsias y proporcionó un diagnóstico definitivo global que se utilizó como patrón de referencia. Cada fragmento de mucosa gástrica examinado condujo a un diagnóstico individual para cada biopsia que se comparó con el patrón de referencia. La variabilidad intra-observador se evaluó en 127 personas que corresponden a una muestra aleatoria de 20% del total de endoscopias hechas a los 72 meses de seguimiento.Resultados: La sensibilidad del diagnóstico de MI y displasia gástrica aumentó de manera significativa con el número de fragmentos de mucosa gástrica evaluados El sitio anatómico de mayor sensibilidad para el diagnóstico de MI y displasia fue la incisura angularis. Para descubrir H. pylori se logró alta sensibilidad con el estudio de un solo fragmento de mucosa gástrica (95.9% y fue independiente del sitio de obtención de la biopsia. El acuerdo intra-observador para el diagnóstico de gastritis crónica fue 86.1% con valor kappa de 0.79 IC 95% (0

  18. Chronic kidney disease

    Science.gov (United States)

    Kidney failure - chronic; Renal failure - chronic; Chronic renal insufficiency; Chronic kidney failure; Chronic renal failure ... 2012_CKD_GL.pdf . McCullough PA. Interface between renal disease ... patients with kidney failure. N Engl J Med . 2010;362(14):1312- ...

  19. The Prevalence of Helicobacter Pylori in Dyspeptic Patients and the Relationship with Endoscopic Diagnosis

    Directory of Open Access Journals (Sweden)

    Ozgur Turk

    2016-07-01

    Full Text Available Aim: One of the most common reasons of the chronic gastritis is Helicobacter pylori (Hp infection. Recent studies reported that Hp gastritis is involved with the duodenal ulcer, atrophic gastritis, dyspepsia, gastric cancer and MALT lymphoma. The prevalence of Hp infection has regional differences. We aimed to determine the frequency of Hp infection in our region and introduce the relationship between results of endoscopy with Hp infection. Material and Method: In this study we analyzed retrospectively 412 patients%u2019 endoscopy results and histopathological results between 2013 January-2014 February.Total 246 patients who have underwent endoscopic biopsy and Hphistopathologically investigated. Results: Male and female ratio was 1.8:1. There were 77 male patients and 139 female patients. Mean age of patients was 46.50±15.05 and range of age was 15 to 82.There was not any statically meaningful association between Hp and patients ages and gender (p>0.05.47.7% of patients were diagnosed as Hp positive, There was a meaningful relationship between Hp ( and chronic gastritis ( groups (p

  20. 克拉霉素联合三联疗法治疗幽门螺杆菌感染相关胃炎的疗效观察%Clinical Observation on Clarithromycin Combined with Triple Therapy in Treatment of Helicobacter Pylori Related Gastritis

    Institute of Scientific and Technical Information of China (English)

    李新建

    2013-01-01

    Objective:The paper is to conduct an clinical observation on ef icacy of clarithromycin combined with triple therapy in treatment of helicobacter pylori related gastritis.Methods:200 admit ed gastritis cases with helicobacter pylori infection were randomly divided into A(n=65),B(n=62),C(n=73)groups,group B was given lansoprazole+clarithromycin therapeutic scheme,group C was applied omeprazole+amoxicil in+furazolidone treatment,while,A groups was given clarithromycin combined with lansoprazole+omeprazole+furazolidone scheme,7 days was 1 course of treatment,and clinical ef icacy were compared between 3 groups after 3 therapeutic courses.Results:Abdominal swel ing symptoms of group B&C had seen no obvious improvement,but the other symptoms after treatment compared with before treatment were significantly improved;clinical symptoms of group A after treatment were significantly improved compared with pretreatment,ef icacy composition,overal ef iciency and cure rate of group A were both superior to that of group B&C,and the former dif erence was statistical y significant(P<0.05).Conclusion:Clarithromycin combined with triple therapy therapeutic scheme in treatment of chronic gastritis with helicobacter pylori infection has good clinical ef ect,and it is worthy of clinical promotion.%  目的:观察并探讨克拉霉素联合三联疗法治疗幽门螺杆菌感染性胃炎的临床疗效。方法:将2009年2月-2012年4月收治的200例幽门螺杆菌感染性胃炎患者随机单盲分为A(n=65)、B(n=62)、C(n=73)三组,B组患者给予克拉霉素+兰索拉唑治疗方案,C组患者给予阿莫西林+奥美拉唑+呋喃唑酮三联治疗方案,A组患者给予克拉霉素联合兰索拉唑片+奥美拉唑+呋喃唑酮方案,以上3组均7 d为一疗程,服药3个疗程后对比临床治疗效果。结果:B、C两组患者治疗后上腹肿胀症状与治疗前无明显改善,其余症状在治疗后相比治疗前均有明显改善;A组患者

  1. Bilateral fracture in atrophic mandible

    Directory of Open Access Journals (Sweden)

    Luciana SIGNORINI

    2006-11-01

    Full Text Available The increase of the elderly population in Brazil has brought a higher number of patients of this age level for dental treatment in several areas of dentistry.Elderly patients are exposed to many kinds of aggressor agents, such as falling down and accidents that cause maxillofacial fractures, which require the specialized assistance of a maxillofacial surgeon. The elderly present a differentiated condition involving systemic changes and use of several drugs that must be taken into consideration when planning the therapeutics ofeach case. The treatment of facial trauma must aim fast recovery along with minimal morbidity. The authors present a case of mandible bilateral fracture in edentulous elderly patient with severe atrophy, treated with titanium plate and screws osteosynthesis. The healing period was satisfactory, without postoperative complications in 18 months follow up.

  2. IS PEPTIC ULCER WITH HELICOBACTER INFEC¬TION THE CAUSE OF CHRONIC URTICARIA?

    Directory of Open Access Journals (Sweden)

    A. Farhoudi

    2000-01-01

    Full Text Available Helicobacter pylori, the most important cause of gastritis and peptic ulcer, has recently been associated with several extradigestive diseases. The aim of this study was to assess the prevalence of Helicobacter pylori infection and effects of bacterium eradication in 50 patients affected by idiopathic chronic urticaria. Helicobacter pylori was assessed by serology or biopsy and urease test or 13C urea breath test. Amoxicillin, bismuth subcitrate (Denol, metronidazole and cimetidine were given to infected patients for 2 weeks. The results of therapy were assessed by urea breath test six weeks after therapy. In response to treatment urticaria clinically regressed in 16 out of 24 patients (66.6%. Thus bacterium eradication was associated with a remission of urticaria symptoms, suggesting a possible role in the pathogenesis of this disorder.

  3. Atypical Chronic Myelogenous Leukemia

    Science.gov (United States)

    ... myeloproliferative neoplasms, leukemia , and other conditions . Chronic Myelomonocytic Leukemia Key Points Chronic myelomonocytic leukemia is a disease ... chance of recovery) and treatment options. Chronic myelomonocytic leukemia is a disease in which too many myelocytes ...

  4. Helicobacter Pylori in periodontal pockets of chronic periodontitis patients with and without type II diabetes mellitus: a randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Savita Sambashivaiah

    2011-09-01

    Full Text Available This randomized controlled study evaluated the association of Helicobacter pylori (H. pylori with chronic periodontitis patients with and without type II Diabetes Mellitus. H. pylori is considered to be a pathogen responsible for gastritis, peptic ulcers and a risk factor for gastric cancer. The aim of the present study was to evaluate the association of H. pylori with chronic periodontitis patients with and without type II diabetes mellitus before and after treatment. The prevalence of H. pylori in periodontal pockets was determined by rapid urease test in a 36 patients, which were grouped as Group 1 (Healthy subjects, Group II (chronic periodontitis patients and Group III (Chronic periodontitis patients with Type II Diabetes Mellitus, 12 in each group before treatment by collecting plaque samples. After treatment, 12 plaque samples were collected and prevalence H. pylori was detected. Group II and Group III had a significantly higher rate of positive results for H. pylori compared to healthy subjects before treatment. After treatment, H. pylori were not detected in Group II and in Group III Only one of 12 chronic periodontitis patients with Type II diabetes mellitus had H. pylori in the periodontal pocket. The prevalence of H. pylori did not differ significantly between the chronic periodontitis patients with and without type II diabetes mellitus. Meticulous scaling and root planning will reduce the prevalence of H. pylori in periodontal pockets.

  5. Magnetic Resonance Imaging Findings in Chronic Carbon Monoxide Intoxication

    Energy Technology Data Exchange (ETDEWEB)

    Durak, A. C.; Coskun, A.; Yikilmaz, A.; Erdogan, F.; Mavili, E.; Guven, M. [Hospital of Erciyes Univ., Kayseri (Turkey). Dept. of Radiology

    2005-05-01

    Purpose: To define the cranial magnetic resonance imaging (MRI) features of the chronic stage of carbon monoxide (CO) poisoning in patients with and without neuropsychiatric sequelae. Material and Methods: Eight patients who had neither symptoms nor neurological sequelae and eight patients with neuropsychiatric sequelae were included in the study. Patients aged between 9 to 57 (mean 32.2 years). All patients had been comatose at initial admittance and awoke after normobaric 100% oxygen therapy within 1-7 days. In this study, the patients were being examined with routine cranial MRI between 1 and 10 years (mean 3.4 years) after exposure to CO. Results: The most common finding was bilateral symmetric hyperintensity of the white matter, which was more significant in the centrum semiovale, with relative sparing of the temporal lobes and anterior parts of the frontal lobes on T2-weighted and FLAIR images in all patients. Cerebral cortical atrophy was seen in 10 patients; mild atrophy of cerebellar hemispheres in 8; and vermian atrophy in 11. Corpus callosum was atrophic in one patient. Bilateral globus pallidus lesions were seen in three patients. The lesions were hypointense on T1-weighted images and hyperintense on T2-weighted and FLAIR images. Conclusion: Patients with severe CO intoxication may develop persistent cerebral changes independently of their neuropsychiatric findings in the chronic stage. They may present with characteristic MRI findings as described here, even if asymptomatic. The history of CO exposure is therefore helpful for recognizing and interpreting the MRI findings of chronic stage CO intoxication.

  6. Chronic mucus hypersecretion

    DEFF Research Database (Denmark)

    Harmsen, L; Thomsen, S F; Sylvan Ingebrigtsen, Truls;

    2010-01-01

    Chronic mucus hypersecretion (CMH) is a common condition in patients with chronic respiratory diseases. Little is known about the incidence, prevalence and determinants of CMH in younger individuals....

  7. Chronic urticaria

    Directory of Open Access Journals (Sweden)

    Sandeep Sachdeva

    2011-01-01

    Full Text Available Chronic urticaria (CU is a disturbing allergic condition of the skin. Although frequently benign, it may sometimes be a red flag sign of a serious internal disease. A multitude of etiologies have been implicated in the causation of CU, including physical, infective, vasculitic, psychological and idiopathic. An autoimmune basis of most of the ′idiopathic′ forms is now hypothesized. Histamine released from mast cells is the major effector in pathogenesis and it is clinically characterized by wheals that have a tendency to recur. Laboratory investigations aimed at a specific etiology are not always conclusive, though may be suggestive of an underlying condition. A clinical search for associated systemic disease is strongly advocated under appropriate circumstances. The mainstay of treatment remains H1 antihistaminics. These may be combined with complementary pharmacopeia in the form of H2 blockers, doxepin, nifedipine and leukotriene inhibitors. More radical therapy in the form of immunoglobulins, plasmapheresis and cyclophosphamide may be required for recalcitrant cases. Autologous transfusion and alternative remedies like acupuncture have prospects for future. A stepwise management results in favorable outcomes. An update on CU based on our experience with patients at a tertiary care centre is presented.

  8. Clinical study of the relationship between Helicobacter pylori and chronic urticaria and prurigo chronica multiformis: effectiveness of eradication therapy for Helicobacter pylori.

    Science.gov (United States)

    Akashi, Rei; Ishiguro, Naoko; Shimizu, Satoru; Kawashima, Makoto

    2011-08-01

    Eighty two patients with chronic urticaria and 17 patients with prurigo chronica multiformis were referred to our department from October 2004 to February 2007 and were tested for Helicobacter pylori antigen using the polyclonal H. pylori stool antigen test (enzyme-linked immunosorbent assay method). H. pylori antigen was detected in 25 (30.5%) of the 82 patients with chronic urticaria and in 10 (58.8%) of the 17 patients with prurigo chronica multiformis. Those findings were not significantly higher than the positive rate for H. pylori stool antigen in healthy age-matched controls. In patients positive for H. pylori antigen, seven of the 25 with chronic urticaria had complications of gastritis (six patients) or gastric ulcers (one patient). Three of the 10 patients with prurigo chronica multiformis had complications of gastritis (two patients) or gastric ulcers (one patient). We examined the therapeutic efficacy of antibacterial treatment for the 17 patients with chronic urticaria and the eight patients with prurigo chronica multiformis who were positive for H. pylori antigen and accepted the treatment based on informed consent. We evaluated the effectiveness of treatment by scoring the skin conditions and by using the Skindex-16, a measure of quality of life. The eradication therapy for H. pylori was more effective for treating prurigo chronica multiformis and the skin symptoms started to improve within 3-14 days after the therapy. However, that therapy was not always effective for treating chronic urticaria. We suggest that H. pylori may be an important pathogenetic factor, especially for prurigo chronica multiformis, and that eradication therapy should be considered to treat intractable cases. PMID:21352335

  9. Contamination by Helicobacter pylori measured by the 13C-Urea-Breath-Test and nutritional status of children with chronic diarrhoea syndrome in Havana City

    International Nuclear Information System (INIS)

    Diarrhoea morbidity shows a slow increasing tendency during the last 10 years in Cuba. In young children the compromise of the gastric acid barrier after a chronic infection with Helicobacter pylori (Hp) is discussed in pathogenic relation to gastritis, duodenal ulcer, chronic diarrhoea, short stature, malabsorption of the B-complex vitamins and malnutrition. The Hp contamination level of the population of the developing world is estimated to be considerably high. Endoscopic studies carried out in Cuban subjects with upper gastrointestinal symptoms show contamination values of 60 to 100%. The current treatment of chronic diarrhoea does not include the elimination of Hp. Cuban children with upper gastrointestinal symptoms show contamination values of more than 60%. There are not available data on the contamination level in apparently healthy Cuban children or those with chronic diarrhoea. In March-April 2000 the prevalence of Hp infection measured in serum by chromatographic immunoassay for detection of Hp IgG antibodies was found to be 94 % in 20 infants and young children with persistent chronic diarrhoea and 100% in 11 apparently healthy children in Havana City. Children with diarrhoea showed a more evident affection of their nutritional status and a higher percentage of positive personal or familiar history of parasitism, giardiasis, gastritis, ulcer, stomatitis and glositis. The validity of the immunological tests in infants is discussed from the point of view of the antibody transference with breast milk. In a sample of 16 different children studied by the 13C-Urea-Breath-Test the contamination level was 50% of the children not affected by diarrhoea and only one of the 6 children with diarrhoea showed positive values

  10. Neuromodulation of chronic headaches

    DEFF Research Database (Denmark)

    Martelletti, Paolo; Jensen, Rigmor H; Antal, Andrea;

    2013-01-01

    The medical treatment of patients with chronic primary headache syndromes (chronic migraine, chronic tension-type headache, chronic cluster headache, hemicrania continua) is challenging as serious side effects frequently complicate the course of medical treatment and some patients may be even...

  11. 乳酸菌胶囊治疗萎缩性阴道炎30例疗效观察%Observation of 30 Cases Atrophic Vaginitis Treatment Lactobacillus Capsules

    Institute of Scientific and Technical Information of China (English)

    商晓毅

    2015-01-01

    目的:分析乳酸菌胶囊治疗萎缩性阴道炎的疗效。方法研究对象选取本院2014年8月~2015年3月收治的60例萎缩性阴道炎患者,随机方法分组。甲组患者接受雌三醇软膏阴道涂抹治疗,乙组患者接受雌三醇软膏涂抹+乳酸菌胶囊置阴道联合治疗。对比两组患者治疗后临床疗效的差异性,并对比临床症状评分。结果治疗后,乙组患者总有效率明显高于甲组,P<0.05,差异有统计学意义。乙组患者各项临床症状评分明显优于甲组,P<0.05,差异有统计学意义。结论乳酸菌胶囊治疗萎缩性阴道炎疗效显著,有利于促进症状消退。%Objective To analyze the efifcacy of the treatment of atrophic vaginitis lactobacillus capsules.MethodsSelected 60 cases of atrophic vaginitis patients from August 2014 to March 2015 in our hospital,randomly grouped. Group A patients received estriol vaginal smear ointment treatment, patients receiving B add ointment estriol vaginal lactobacillus capsules set combination therapy. Compared two groups of patients after treatment differences in clinical efifcacy and comparative clinical symptom scores.Results After treatment, patients in Group B was significantly higher than the total efifciency of Group A, the difference was statistically significant (P<0.05). The clinical symptom score was significantly better than Group A Group B patients, the difference was statistically signiifcant (P<0.05).ConclusionTreatment of atrophic vaginitis lactobacillus capsules significant effect, and promoting the symptoms subside, can be recommended to use.

  12. 超脉冲点阵激光治疗面部萎缩性瘢痕的护理%Nursing Care of atrophic facial scars after the ultrapulse fractional laser

    Institute of Scientific and Technical Information of China (English)

    黎颖诗; 黄艳; 吴绿叶; 杨海波

    2011-01-01

    目的:探讨超脉冲点阵激光治疗面部萎缩性瘢痕的护理方法.方法:对72例面部萎缩性瘢痕患者从心理护理、宣教、术中配合、医患沟通、术后护理等方面,总结探讨该护理方法对提高治疗效率,减少术后反应的重要性.结果:经过1~2次的治疗和良好的护理,67例患者瘢痕外观有明显改善,皮肤光洁、亮泽,没有明显色素沉着.显效49例,占68.06%;有效18例,占25%;无效5例,占6.94%.结论:超脉冲点阵激光治疗面部萎缩性瘢痕微创、安全、效果好.实施护理对策,可以提高治疗效率;良好的护理是治疗效果的有效保证.%Objective To summarize the nursing care method of atrophic facial scars after the ultrapulse fractional laser.Methods Summary the methods of care including the psychological care of patients, missions,co-operation, patient communication, postoperative care about 72 cases of atrophic facial scars,study the importance of the care to improve the treatment efficiency and reduce the postoperative response. Results After 1 or 2 times of treatment and good care, 72 patients had significant improvement in the appearance of scars, skin smooth, glossy, with no obvious pigmentation. 49 cases markedly, accounting for 68.06%, effective in 23 cases, accounting for 31.94%. Conclusions The pulsed laser treatment of facial atrophic lattice scars is minimally invasive, safe and effective. Implementation of care measures can improve the treatment efficiency, good treatment and effective care is guaranteed.

  13. 自体脂肪移植修复面部凹陷性及萎缩性瘢痕%Autologous fat grafting for facial depressed and atrophic scars

    Institute of Scientific and Technical Information of China (English)

    后晨蓉; 刘祥厦; 张有良; 曾瑞曦; 苏爱云; 唐庆

    2014-01-01

    Objective To evaluate the methodology and clinical efficacy of autologous fat grafting for the reconstruction of facial depressed and atrophic scars. Methods 10 patients with facial depressed and atrophic scars were treated with autologous fat grafting.Fat harvest, refinement and injection were done by 3M3L's fat grafting technique. Every patient was treated 1- 3 times with an interval of 3- 6 months.The improvement of facial contour deformity and skin texture were assessed after surgery. Results All patients were followed up postoperatively within 3- 12 months.No complications such as infection,cysts,calcification, vascular or nerve injury occurred,nor new deformity and scars were observed.The contour deformity was corrected significantly compared before. The local skin texture of scars was also improved greatly.Patients were all satisfied with the cosmetic results. Conclusion Although further studies are required to provide surgeons with definitive guidelines for the implementation of fat grafting,we propose autologous fat grafting is a feasible minimally invasive and safe technique for facial depressed and atrophic scars.%目的:探讨自体脂肪移植修复面部凹陷性及萎缩性瘢痕的方法和临床疗效。方法:对10例面部凹陷性及萎缩性瘢痕患者采用自体脂肪移植进行治疗。脂肪获取、提纯及注射采用3M3L移植技术。每例自体脂肪移植1~3次,每次间隔3~6个月,综合评价患者术后面部轮廓畸形、瘢痕皮肤质地改善情况。结果:患者均获随访3个月~1年,无感染、囊肿、钙化、血管和神经损伤等并发症发生,也未产生新畸形及新瘢痕。轮廓凹陷畸形得到矫正,瘢痕皮肤质地及色泽有所改善,患者均对治疗效果满意。结论:自体脂肪移植是一种治疗面部凹陷性及萎缩性瘢痕可行的微创方法。

  14. Helicobacter pylori infection has no impact on manometric and pH-metric findings in adolescents and young adults with gastroesophageal reflux and antral gastritis: eradication results to no significant clinical improvement

    Directory of Open Access Journals (Sweden)

    Ioannis Xinias

    2013-02-01

    Full Text Available The relationship between Helicobacter pylori (Hp gastritis and gastroesophageal reflux disease (GERD remains controversial. The aim was to investigate the association between Hp infection and gastroesophageal reflux (GER and the impact of Hp eradication on esophageal acid exposure and motility in adolescents and young adults with Hp gastritis and GERD. Sixty-four patients with symptoms suggestive for GERD, of which 40 Hp-positive (group A and 24 Hp-negative (group B, underwent endoscopy-biopsy, esophageal manometry and 24-hour pH-metry. All group A patients received eradication treatment and were re-evaluated six months later again with 24-hour pH-metry, esophageal manometry, endoscopy-biopsy and clinical assessment. At inclusion, there were no significant differences between the two groups regarding sex, age, grade of endoscopic esophagitis, manometric and pH-metry findings. All Hp-positive patients had an antral predominant gastritis. Eradication of Hp was successful in all patients, and gastritis and esophagitis were healed in all patients. The mean lower esophageal sphincter pressure (LESP increased significantly from 11.25 mmHg before to 11.71 mmHg after eradication (P<0.05. A significant decrease in reflux index was observed (mean RI 6.02% before versus 4.96% after eradication (P<0.05. However clinical symptoms of GER improved not significantly after 6 months follow up. Conclusively, in children and young adults with GER symptoms and GERD, the presence or absence of Hp has no impact on manometric and pH-metric findings. Eradication of Hp infection results in increase in LESP with a consequent decrease in esophageal acid exposure but not significant clinical improvement.

  15. The Genetic Diversity of Helicobacter pylori Virulence Genes Is Not Associated with Gastric Atrophy Progression

    OpenAIRE

    Kita, Masahide; Yokota,Kenji; Okada, Hiroyuki; Take,Susumu; Takenaka, Ryuta; Kawahara, Yoshiro; Oguma, Keiji; Matsushita, Osamu; Yamamoto, Kazuhide

    2013-01-01

    Atrophy of the gastric mucosa is a precursor of intestinal-type gastric cancer, and Helicobacter pylori infection causes atrophic gastritis. The aim of this study was to determine whether the genetic diversity of H. pylori virulence genes is associated with the development and progression of gastric atrophy in humans. We isolated and cultured H. pylori strains from patients with gastric ulcer and duodenal ulcer accompanied by atrophic gastritis in background mucosa. H. pylori strains were sto...

  16. Management of Helicobacter pylori

    OpenAIRE

    Shiota, Seiji; Yamaoka, Yoshio

    2010-01-01

    Meta-analysis has shown that successful Helicobacter pylori eradication therapy improved atrophic gastritis and intestinal metaplasia. Moreover, successful eradication therapy against atrophic gastritis has led to the suppression of the incidence of metachronous gastric cancer. Thus, the Japanese Society for Helicobacter Research concluded that all ‘H. pylori-infected persons’ should be considered for eradication therapy, irrespective of any background diseases. Successful eradication can pre...

  17. Untying chronic pain

    OpenAIRE

    Häuser, Winfried; Wolfe, Frederik; Henningsen, Peter; Schmutzer, Gabriele; Brähler, Elmar; Hinz, Andreas

    2014-01-01

    Background: Chronic pain is a major public health problem. The impact of stages of chronic pain adjusted for disease load on societal burden has not been assessed in population surveys. Methods: A cross-sectional survey with 4360 people aged ≥ 14 years representative of the German population was conducted. Measures obtained included demographic variables, presence of chronic pain (based on the definition of the International Association for the Study of Pain), chronic pain stages (by chronic ...

  18. Chronic pain after hysterectomy

    DEFF Research Database (Denmark)

    Brandsborg, B.; Nikolajsen, L.; Kehlet, H.;

    2008-01-01

    BACKGROUND: Chronic pain is a well-known adverse effect of surgery, but the risk of chronic pain after gynaecological surgery is less established. METHOD: This review summarizes studies on chronic pain following hysterectomy. The underlying mechanisms and risk factors for the development of chronic...... post-hysterectomy pain are discussed. RESULTS AND CONCLUSION: Chronic pain is reported by 5-32% of women after hysterectomy. A guideline is proposed for future prospective studies Udgivelsesdato: 2008/3...

  19. Chronic pain after hysterectomy

    DEFF Research Database (Denmark)

    Brandsborg, B; Nikolajsen, L; Kehlet, Henrik;

    2008-01-01

    BACKGROUND: Chronic pain is a well-known adverse effect of surgery, but the risk of chronic pain after gynaecological surgery is less established. METHOD: This review summarizes studies on chronic pain following hysterectomy. The underlying mechanisms and risk factors for the development of chronic...... post-hysterectomy pain are discussed. RESULTS AND CONCLUSION: Chronic pain is reported by 5-32% of women after hysterectomy. A guideline is proposed for future prospective studies. Udgivelsesdato: 2008-Mar...

  20. The Influence of Prolonged Acetylsalicylic Acid Supplementation-Induced Gastritis on the Neurochemistry of the Sympathetic Neurons Supplying Prepyloric Region of the Porcine Stomach.

    Science.gov (United States)

    Palus, Katarzyna; Całka, Jarosław

    2015-01-01

    This experiment was designed to establish the localization and neurochemical phenotyping of sympathetic neurons supplying prepyloric area of the porcine stomach in a physiological state and during acetylsalicylic acid (ASA) induced gastritis. In order to localize the sympathetic perikarya the stomachs of both control and acetylsalicylic acid treated (ASA group) animals were injected with neuronal retrograde tracer Fast Blue (FB). Seven days post FB injection, animals were divided into a control and ASA supplementation group. The ASA group was given 100 mg/kg of b.w. ASA orally for 21 days. On the 28th day all pigs were euthanized with gradual overdose of anesthetic. Then fourteen-micrometer-thick cryostat sections were processed for routine double-labeling immunofluorescence, using primary antisera directed towards tyrosine hydroxylase (TH), dopamine β-hydroxylase (DβH), neuropeptide Y (NPY), galanin (GAL), neuronal nitric oxide synthase (nNOS), leu 5-enkephalin (LENK), cocaine- and amphetamine- regulated transcript peptide (CART), calcitonin gene-related peptide (CGRP), substance P (SP) and vasoactive intestinal peptide (VIP). The data obtained in this study indicate that postganglionic sympathetic nerve fibers supplying prepyloric area of the porcine stomach originate from the coeliac-cranial mesenteric ganglion complex (CCMG). In control animals, the FB-labelled neurons expressed TH (94.85 ± 1.01%), DβH (97.10 ± 0.97%), NPY (46.88 ± 2.53%) and GAL (8.40 ± 0.53%). In ASA group, TH- and DβH- positive nerve cells were reduced (85.78 ± 2.65% and 88.82 ± 1.63% respectively). Moreover, ASA- induced gastritis resulted in increased expression of NPY (76.59 ± 3.02%) and GAL (26.45 ± 2.75%) as well as the novo-synthesis of nNOS (6.13 ± 1.11%) and LENK (4.77 ± 0.42%) in traced CCMG neurons. Additionally, a network of CART-, CGRP-, SP-, VIP-, LENK-, nNOS- immunoreactive (IR) nerve fibers encircling the FB-positive perikarya were observed in both intact and ASA

  1. The Influence of Prolonged Acetylsalicylic Acid Supplementation-Induced Gastritis on the Neurochemistry of the Sympathetic Neurons Supplying Prepyloric Region of the Porcine Stomach.

    Directory of Open Access Journals (Sweden)

    Katarzyna Palus

    Full Text Available This experiment was designed to establish the localization and neurochemical phenotyping of sympathetic neurons supplying prepyloric area of the porcine stomach in a physiological state and during acetylsalicylic acid (ASA induced gastritis. In order to localize the sympathetic perikarya the stomachs of both control and acetylsalicylic acid treated (ASA group animals were injected with neuronal retrograde tracer Fast Blue (FB. Seven days post FB injection, animals were divided into a control and ASA supplementation group. The ASA group was given 100 mg/kg of b.w. ASA orally for 21 days. On the 28th day all pigs were euthanized with gradual overdose of anesthetic. Then fourteen-micrometer-thick cryostat sections were processed for routine double-labeling immunofluorescence, using primary antisera directed towards tyrosine hydroxylase (TH, dopamine β-hydroxylase (DβH, neuropeptide Y (NPY, galanin (GAL, neuronal nitric oxide synthase (nNOS, leu 5-enkephalin (LENK, cocaine- and amphetamine- regulated transcript peptide (CART, calcitonin gene-related peptide (CGRP, substance P (SP and vasoactive intestinal peptide (VIP. The data obtained in this study indicate that postganglionic sympathetic nerve fibers supplying prepyloric area of the porcine stomach originate from the coeliac-cranial mesenteric ganglion complex (CCMG. In control animals, the FB-labelled neurons expressed TH (94.85 ± 1.01%, DβH (97.10 ± 0.97%, NPY (46.88 ± 2.53% and GAL (8.40 ± 0.53%. In ASA group, TH- and DβH- positive nerve cells were reduced (85.78 ± 2.65% and 88.82 ± 1.63% respectively. Moreover, ASA- induced gastritis resulted in increased expression of NPY (76.59 ± 3.02% and GAL (26.45 ± 2.75% as well as the novo-synthesis of nNOS (6.13 ± 1.11% and LENK (4.77 ± 0.42% in traced CCMG neurons. Additionally, a network of CART-, CGRP-, SP-, VIP-, LENK-, nNOS- immunoreactive (IR nerve fibers encircling the FB-positive perikarya were observed in both intact and ASA

  2. Acute and Chronic Toxicity of an Aqueous Fraction of the Stem Bark of Stryphnodendron adstringens (Barbatimão) in Rodents.

    Science.gov (United States)

    Costa, Marco Antonio; Palazzo de Mello, João Carlos; Kaneshima, Edílson Nobuyoshi; Ueda-Nakamura, Tânia; Dias Filho, Benedito Prado; Audi, Elisabeth Aparecida; Nakamura, Celso Vataru

    2013-01-01

    Stryphnodendron adstringens has a high tannin content and is used as an antiseptic and antimicrobial and in the treatment of leucorrhea, gonorrhea, wound healing, and gastritis. The present study evaluated the toxic effects of the heptamer prodelphinidin (F2) from the stem bark of S. adstringens in rodents. In the acute toxicity test, the mice that received oral doses exhibited reversible effects, with an LD50 of 3.015 mg · kg(-1). In the chronic toxicity test at 90 days, Wistar rats were treated with different doses of F2 (10, 100, and 200 mg · kg(-1)). In the biochemical, hematological, and histopathological examinations and open-field test, the different dose groups did not exhibit significant differences compared with controls. The present results indicate that F2 from the stem bark of S. adstringens caused no toxicity with acute and chronic oral treatment in rodents at the doses administered.

  3. Acute and Chronic Toxicity of an Aqueous Fraction of the Stem Bark of Stryphnodendron adstringens (Barbatimão in Rodents

    Directory of Open Access Journals (Sweden)

    Marco Antonio Costa

    2013-01-01

    Full Text Available Stryphnodendron adstringens has a high tannin content and is used as an antiseptic and antimicrobial and in the treatment of leucorrhea, gonorrhea, wound healing, and gastritis. The present study evaluated the toxic effects of the heptamer prodelphinidin (F2 from the stem bark of S. adstringens in rodents. In the acute toxicity test, the mice that received oral doses exhibited reversible effects, with an LD50 of 3.015 mg·kg−1. In the chronic toxicity test at 90 days, Wistar rats were treated with different doses of F2 (10, 100, and 200 mg·kg−1. In the biochemical, hematological, and histopathological examinations and open-field test, the different dose groups did not exhibit significant differences compared with controls. The present results indicate that F2 from the stem bark of S. adstringens caused no toxicity with acute and chronic oral treatment in rodents at the doses administered.

  4. Progression of chronic hepatitis and preneoplasia in Helicobacter hepaticus-infected A/JCr mice.

    Science.gov (United States)

    Rogers, Arlin B; Boutin, Samuel R; Whary, Mark T; Sundina, Nataliya; Ge, Zhongming; Cormier, Kathleen; Fox, James G

    2004-01-01

    Helicobacter hepaticus infection induces sustained inflammation and carcinoma of the liver in A/JCr mice, and serves as a model of human cancers associated with viral hepatitis and H. pylorichronic gastritis. Here we describe the pathogenesis of premalignant disease in A/JCr mice infected with H. hepaticus. We inoculated dams intragestationally and/or pups postnatally, and evaluated offspring at 3, 6, or 12 months. Mice infected at or before 3 weeks of age, but not at 12 weeks, developed disease. Male mice were most affected, but expressed a bimodal pattern of susceptibility. Males exhibited lobular necrogranulomatous and interface (chronic active) hepatitis, while females usually developed intraportal (chronic persistent) hepatitis. Portal inflammation was slowly progressive, with tertiary lymphoid nodule development by 12 months. Hepatic bacterial load and preneoplastic lesions, including clear and tigroid cell foci of cellular alteration, were correlated with lobular hepatitis severity. No extrahepatic surrogate disease marker reliably predicted individual hepatitis grade. In conclusion, gender and bacterial exposure timing are key determinants of H. hepaticus disease outcomes. Intrahepatic inflammation is driven by local signals characterized by a vigorous but nonsterilizing immune response. Continued study of chronic hepatitis progression may reveal therapeutic targets to reduce the risk of hepatocellular carcinoma.

  5. Chronic mucus hypersecretion

    DEFF Research Database (Denmark)

    Ulrik, Charlotte Suppli; von Linstow, Marie-Louise; Nepper-Christensen, Steen;

    2005-01-01

    To investigate if chronic mucus hypersecretion (CMH) can be used as a marker of asthma in young adults.......To investigate if chronic mucus hypersecretion (CMH) can be used as a marker of asthma in young adults....

  6. Chronic Diarrhea in Children

    Science.gov (United States)

    ... can include cramping abdominal pain nausea or vomiting fever chills bloody stools Children with chronic diarrhea who have ... can include cramping, abdominal pain, nausea or vomiting, fever, chills, or bloody stools. Children with chronic diarrhea who ...

  7. Chronic inflammatory demyelinating polyneuropathy

    Science.gov (United States)

    Polyneuropathy - chronic inflammatory; CIDP; Chronic inflammatory polyneuropathy; Guillain-Barré - CIDP ... CIDP is one cause of damage to nerves outside the brain or spinal cord ( peripheral neuropathy ). Polyneuropathy ...

  8. Chronic fatigue syndrome

    Science.gov (United States)

    Bennett RM. Fibromyalgia, chronic fatigue syndrome, and myofascial pain. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine . 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 274. Engleberg NC. Chronic ...

  9. "Chronic Lyme Disease"

    Science.gov (United States)

    ... Content Marketing Share this: Main Content Area "Chronic Lyme Disease" What is "chronic Lyme disease?" Lyme disease is an infection caused by ... J Med 357:1422-30, 2008). How is Lyme disease treated? For early Lyme disease, a short ...

  10. Prostaglandins and chronic inflammation

    OpenAIRE

    Aoki, Tomohiro; Narumiya, Shuh

    2012-01-01

    Chronic inflammation is the basis of various chronic illnesses including cancer and vascular diseases. However, much has yet to be learned how inflammation becomes chronic. Prostaglandins (PGs) are well established as mediators of acute inflammation, and recent studies in experimental animals have provided evidence that they also function in transition to and maintenance of chronic inflammation. One role PGs play in such processes is amplification of cytokine signaling. As such, PGs can facil...

  11. Chronic Inflammatory Demyelinating Polyneuropathy

    OpenAIRE

    Dimachkie, Mazen M.; Barohn, Richard J.

    2013-01-01

    Chronic Inflammatory polyneuropathies are an important group of neuromuscular disorders that present chronically and progress over more than 8 weeks, being referred to as chronic inflammatory demyelinating polyneuropathy (CIDP). Despite tremendous progress in elucidating disease pathogenesis, the exact triggering event remains unknown. Our knowledge regarding diagnosis and management of CIDP and its variants continues to expand, resulting in improved opportunities for identification and treat...

  12. Distribution of H.pylori antigens in gastric mucosa and its significance

    Institute of Scientific and Technical Information of China (English)

    陆新良; 钱可大; 唐训球; 朱永良

    2004-01-01

    Objective: To investigate the distribution of H. pylori antigens in the gastric mucosa in patients with H. pylori infection, and the relationship between the distribution and gastric cancer. Methods: Of 112 patients confirmed by pathological study to have chronic superficial gastritis, precancerous changes (chronic atrophic gastritis, intestinal metaplasia or atypical hyperplasia) and gastric cancer, 28 were H. pylori negative and 84 were H. pylori positive. H. pylori antigens in the gastric mucosa were detected by immunohistochemistry. Results: The H. pylori positive group, comprised 12 of 22 (50.0%) in the chronic superficial gastritis group, 22 of 25 (88.0%) in the precancerous changes group and 13 of 35 (37.1%) in the gastric cancer group. The positive rates of H. pylori antigens in the cytoplasm progressively increased, respectively at 0.0% (0/12),63.6% (14/22) and 84.6% (11/13) for the same groups (χ2=19.76, P=0.000); H.pylori antigens were located in the mucus layer and above the neck of the mucosal gland in 9 of 12 (75.0%) cases with chronic superficial gastritis, at the neck of the mucosal gland and the isthmus in 12 of 22 (54.5%) cases with precancerous changes, below the isthmus in 9 of 13 (69.2%) cases with gastric cancer (x2=25.30, P=0.000). In the H. pylori negative group, no H.pylori antigen was observed. Conclusion: With the progression of chronic superficial gastritis→precancerous changes→gastric cancer, H. pylori antigens progressively migrated from the outer part to the inner part of the cell, and from the superficial to the deep gastric mucosa.

  13. Distribution of H.pylori antigens in gastric mucosa and its significance

    Institute of Scientific and Technical Information of China (English)

    陆新良; 钱可大; 唐训球; 朱永良

    2004-01-01

    Objective: To investigate the distribution of H.p),lori antigens in the gastric mucosa in patients with H.pylori infection, and the relationship between the distribution and gastric cancer. Methods: Of 112 patients confirmed by pathological study to have chronic superficial gastritis, precancerous changes (chronic atrophic gastritis, intestinal metaplasia or atypical hyperplasia) and gastric cancer, 28 were H.pylori negative and 84 were H.pylori positive. H.pylori antigens in the gastric mucosa were detected by immunohistochemistry. Results: The H.pylori positive group, comprised 12 of 22 (50.0%) in the chronic superficial gastritis group, 22 of 25 (88.0%) in the precancerous changes group and 13 of 35 (37.1%) in the gastric cancer group. The positive rates of H.pylori antigens in the cytoplasm progressively increased, respectively at 0.0% (0/12), 63.6% (14/22) and 84.6% (11/13) for the same groups (χ2= 19.76, P=0.000); H.pylori antigens were located in the mucus layer and above the neck of the mucosal gland in 9 of 12 (75.0%) cases with chronic superficial gastritis, at the neck of the mucosal gland and the isthmus in 12 of 22 (54.5%) cases with precancerous changes, below the isthmus in 9 of 13 (69.2%) cases with gastric cancer (χ2=25.30, P=0.000). In the H.pvlori negative group, no H.pylori antigen was observed. Conclusion: With the progression of chronic superficial gastritis→precancerous changes→gastric cancer, H.pylori antigens progressively migrated from the outer part to the inner part of the cell, and from the superficial to the deep gastric mucosa.

  14. Chronic granulomatous disease associated with chronic glomerulonephritis

    DEFF Research Database (Denmark)

    Frifelt, J J; Schønheyder, Henrik Carl; Valerius, Niels Henrik;

    1985-01-01

    A boy with chronic granulomatous disease (CGD) developed glomerulonephritis at the age of 12 years. The glomerulonephritis progressed to terminal uraemia at age 15 when maintenance haemodialysis was started. The clinical course was complicated by pulmonary aspergillosis and Pseudomonas septicaemia...

  15. 2790 nm钇-钪-镓-石榴石点阵激光治疗凹陷性痤疮瘢痕的疗效%Effect of 2790 nm YSGG fractional laser on facial atrophic acne scars

    Institute of Scientific and Technical Information of China (English)

    杨鹏; 麦跃; 李娟; 孙林潮

    2013-01-01

    目的 观察评估2790 nm钇-钪-镓石榴石(YSGG)点阵激光治疗面部凹陷性痤疮瘢痕的疗效及安全性.方法 将患者随机分成两组,A组使用2790 nm YSGG点阵激光非剥脱模式治疗1次,再以剥脱模式治疗;B组仅使用2790 nm YSGG点阵激光非剥脱模式进行治疗.每组共治疗4次,每间隔6周治疗1次,治疗前后均以VISIA(R)数字皮肤分析系统对面部瘢痕和肤质进行评分和统计比较,并由患者、医师共同评价满意度.结果 38例患者均完成4次治疗,治疗后所有凹陷性瘢痕均有不同程度的改善,A、B组治愈率分别为56.0%和30.8%,总有效率81.6%,无1例严重不良反应,A组优于B组.结论 2790 nm YSGG点阵激光具有效果明显、精确度高、损伤小、操作方便的优点,且治疗后并发症少、色素沉着程度轻,2790 nm YSGG点阵激光是治疗面部浅表瘢痕安全、有效的方法之一.%Objective To evaluate the effect of resurfacing facial atrophic acne scars with 2790 nm YSGG fractional laser.Methods 38 patients with facial atrophic acne scars were treated with the 2790 nm YSGG fractional laser.All patients were randomly divided into two groups:group A using the combination with ablative and non-ablative mode of treatment; group B only using the non-ablative mode throughout the entire face,four treatment sessions for each patient,6 weeks interval.Comparative photographs were taken by using VISIA.Specific complexion analysis was used to identify and quantify depressed scars and texture,and patient satisfaction was graded with a 4-point scale.Results All of facial atrophic acne scars obtained different degree of improvement were treated by 4 times.In groups A and B,cure rate achieved 56.0 % and 30.8 %,respectively.All the 38 patients had a chieved efficacy (81.6 %),and they were satisfied with the results (84.2 %).No severe side effect was observed.Conclusions 2790 nm YSGG laser is easy to manipulate and is more exactly than

  16. 冷触Nd:YAG激光治疗面部痤疮瘢痕的临床疗效及不良反应%Improvement and Side Effect of Atrophic Acne Scars with CoolTouch Ⅲ Nd: YAG Laser

    Institute of Scientific and Technical Information of China (English)

    蔡宏; 宋为民; 金宪强; 沈静; 郑涵; 赵广

    2011-01-01

    目的 评价冷触Nd:YAG激光治疗面部痤疮凹陷性瘢痕的疗效及其发生机制和不良反应.方法 应用冷触Nd:YAG激光治疗面部痤疮凹陷瘢痕患者20例,波长1 320nm,光斑直径10mm,平均治疗能量密度14 J/cm2.治疗4~9次(平均6次),每次间隔1个月.结果 痤疮凹陷性瘢痕得到较满意改善,病程短于2年的患者显效率达60.0%,好转率为40.0%,满意率100.0%.不良反应为一过性红斑、水肿.结论 冷触Nd:YAG激光治疗痤疮凹陷性瘢痕安全、有效,不良反应发生率低.%Objective To evaluate the efficacy and safety of CoolTouch Ⅲ Nd: YAG laser for atrophic acne scars.Methods Twenty patients (skin phototypes Ⅲ-Ⅳ) with facial atrophic acne scars received a mean of 6 (ranged 4-9) sessions of treatment monthly with a 1 320 nm CoolTouch Ⅲ Nd: YAC laser. A spot size of 10 mm was used, the average energy density was 14 J/ cm2. The improvement rate was obtained by physician and patient together. Furthermore, the physician assessment scores of improvement were also determined by side-by-side comparison of preoperative and postoperative photographs through B. Drenos ECCA grading scale.Results Acne scars were significantly improved by both physician and patient assessment. The average efficiency rate was 60% , improvement rate was 40% , and the satisfactory rate was 100%. The adverse effects were transient erythema and purpura. Conclusions Nonablative laser skin resurfacing with CoolTouch Ⅲ Nd: YAC laser can effectively improve the appearance of facial acne scars with minimal adverse sequelae.

  17. Modern views on the pathogenesis of hard dental tissues and periodontium lesions and means of their treatment in children with chronic diseases of the gastrointestinal tract

    Directory of Open Access Journals (Sweden)

    Krupey V.Y.

    2014-09-01

    Full Text Available Changes in the mouth covity often reflect regularities of pathogenesis of a number of disease states, and primarily from the digestive tract. Therefore, the purpose of the study was to clarify pathogenesis of certain lesions of hard dental tissues and periodontal tissues in children with chronic diseases of the gastrointestinal tract and development of schemes for their treatment. The study observed 441 children aged from 7 to 15 years with dental caries and generalized chronic catarrhal gingivitis on the background of chronic gastritis and duodenitis, duodenal ulcer and malabsorption syndrome. All the children were divided into 2 groups - basic and comparison one. The study identified the most dan¬gerous and little-known way of pathogenesis, which passes through the general processes of reducing the production of various proteins (immune system and antiseptics, is a violation of the general and local resistance and, ultimately, mineral metabolism. Such disorders impair complete mineralization of tooth enamel, reduce optimal composition and properties of saliva stimulating glycolysis processes in oral cavity. Prevention of dental caries and generalized chronic catarrhal gingivitis in children with chronic pathology of the gastrointestinal tract is based on the use of developed therapeutic and prophylactic complex, which includes mucosal gel Kvertulin, probiotic Latsidofil and drug Calcium D.

  18. The immunomodulatory properties of Helicobacter pylori confer protection against allergic and chronic inflammatory disorders

    Directory of Open Access Journals (Sweden)

    Anne eMüller

    2012-02-01

    Full Text Available Chronic infection with the gastric bacterial pathogen Helicobacter pylori causes gastritis and predisposes carriers to a high risk of developing gastric and duodenal ulcers, gastric cancer and gastric lymphoma, but has also recently been shown to protect against certain allergic and chronic inflammatory disorders. The immunomodulatory properties that allow the bacteria to persist for decades in infected individuals in the face of a vigorous, yet ultimately non-protective, innate and adaptive immune response may at the same time confer protection against allergies, asthma and inflammatory bowel diseases. Experimental evidence from mouse models suggests that H. pylori has evolved to skew the adaptive immune response towards immune tolerance rather than immunity, which promotes persistent infection on the one hand, and inhibits auto-aggressive and allergic T-cell responses on the other. Regulatory T-cells mediating peripheral immune tolerance have emerged as key cellular players in facilitating persistent infection as well as protection from allergies, in both observational studies in humans and experimental work in mice. Recent data suggest that H. pylori actively targets dendritic cells to promote tolerance induction. The findings discussed in this review raise the possibility of harnessing the immunomodulatory properties of H. pylori for the prevention and treatment of allergic and auto-immune diseases, and also provide new insights relevant for H. pylori-specific vaccine development.

  19. Chronic penile strangulation

    OpenAIRE

    Lopes, Roberto I.; Silvia I Lopes; Roberto N. Lopes

    2003-01-01

    Chronic penile strangulation is exceedingly rare with only 5 cases previously reported. We report an additional case of progressive penile lymphedema due to chronic intermittent strangulation caused by a rubber band applied to the penile base for 6 years. A 49-year-old man presented incapacity to exteriorize the glans penis. For erotic purposes, he had been using a rubber-enlarging band placed in the penile base for 6 years. With chronic use, he noticed that his penis swelled. Physical examin...

  20. Chronic obstructive pulmonary disease

    OpenAIRE

    NR Anthonisen

    2007-01-01

    The global prevalence of physiologically defined chronic obstructive pulmonary disease (COPD) in adults aged >40 yr is approximately 9-10 per cent. Recently, the Indian Study on Epidemiology of Asthma, Respiratory Symptoms and Chronic Bronchitis in Adults had shown that the overall prevalence of chronic bronchitis in adults >35 yr is 3.49 per cent. The development of COPD is multifactorial and the risk factors of COPD include genetic and environmental factors. Pathological changes in COPD are...