WorldWideScience

Sample records for choosing specific mic

  1. Choosing an information system to meet specific needs.

    Science.gov (United States)

    Burton, J A

    1983-07-01

    Because of the increasing number of information systems on the market today, the user must select the system wisely according to the vendor's ability to solve specific company needs. An organization must know its filing and retrieval requirements, its potential for growth, etc., and must then contact only those vendors that fit specific company requirements. The vendor's reputation in the field, service history, "after-sales support," and ability to supply cost analyses should all be examined. PMID:10263971

  2. Using ROC curves to choose minimally important change thresholds when sensitivity and specificity are valued equally: the forgotten lesson of pythagoras. theoretical considerations and an example application of change in health status.

    Directory of Open Access Journals (Sweden)

    Robert Froud

    Full Text Available Receiver Operator Characteristic (ROC curves are being used to identify Minimally Important Change (MIC thresholds on scales that measure a change in health status. In quasi-continuous patient reported outcome measures, such as those that measure changes in chronic diseases with variable clinical trajectories, sensitivity and specificity are often valued equally. Notwithstanding methodologists agreeing that these should be valued equally, different approaches have been taken to estimating MIC thresholds using ROC curves.We aimed to compare the different approaches used with a new approach, exploring the extent to which the methods choose different thresholds, and considering the effect of differences on conclusions in responder analyses.Using graphical methods, hypothetical data, and data from a large randomised controlled trial of manual therapy for low back pain, we compared two existing approaches with a new approach that is based on the addition of the sums of squares of 1-sensitivity and 1-specificity.There can be divergence in the thresholds chosen by different estimators. The cut-point selected by different estimators is dependent on the relationship between the cut-points in ROC space and the different contours described by the estimators. In particular, asymmetry and the number of possible cut-points affects threshold selection.Choice of MIC estimator is important. Different methods for choosing cut-points can lead to materially different MIC thresholds and thus affect results of responder analyses and trial conclusions. An estimator based on the smallest sum of squares of 1-sensitivity and 1-specificity is preferable when sensitivity and specificity are valued equally. Unlike other methods currently in use, the cut-point chosen by the sum of squares method always and efficiently chooses the cut-point closest to the top-left corner of ROC space, regardless of the shape of the ROC curve.

  3. Bacterial Species-Specific Activity of a Fluoroquinolone against Two Closely Related Pasteurellaceae with Similar MICs: Differential In Vitro Inoculum Effects and In Vivo Efficacies

    Science.gov (United States)

    Lhermie, Guillaume; El Garch, Farid; Toutain, Pierre-Louis; Ferran, Aude A.; Bousquet-Mélou, Alain

    2015-01-01

    We investigated the antimicrobial activity of a fluoroquinolone against two genetically close bacterial species belonging to the Pasteurellaceae family. Time-kill experiments were used to measure the in vitro activity of marbofloxacin against two strains of Mannheimia haemolytica and Pasteurella multocida with similar MICs. We observed that marbofloxacin was equally potent against 105 CFU/mL inocula M. haemolytica and P. multocida. However, an inoculum effect was observed with P. multocida, meaning that marbofloxacin activity was decreased against a 108 CFU/mL inoculum, whereas no inoculum effect was observed with M. haemolytica. Marbofloxacin activity was also tested in a lung infection model with immunocompromised mice intratracheally infected with 109 CFU of each bacteria. At the same dose, the clinical and bacteriological outcomes were much better for mice infected with M. haemolytica than for those infected with P. multocida. Moreover, bacteriological eradication was obtained with a lower marbofloxacin dose for mice infected with M. haemolytica. Our results suggest that the differential in vivo marbofloxacin efficacy observed with the two bacterial species of similar MIC could be explained by a differential inoculum effect. Consequently, MICs determined on 105 CFU inocula were not predictive of the differences in antibiotic efficacies against high bacterial inocula of closely related bacterial strains. These results could stimulate further investigations on bacterial species-specific antibiotic doses in a clinical setting. PMID:26506096

  4. Bacterial Species-Specific Activity of a Fluoroquinolone against Two Closely Related Pasteurellaceae with Similar MICs: Differential In Vitro Inoculum Effects and In Vivo Efficacies.

    Directory of Open Access Journals (Sweden)

    Guillaume Lhermie

    Full Text Available We investigated the antimicrobial activity of a fluoroquinolone against two genetically close bacterial species belonging to the Pasteurellaceae family. Time-kill experiments were used to measure the in vitro activity of marbofloxacin against two strains of Mannheimia haemolytica and Pasteurella multocida with similar MICs. We observed that marbofloxacin was equally potent against 105 CFU/mL inocula M. haemolytica and P. multocida. However, an inoculum effect was observed with P. multocida, meaning that marbofloxacin activity was decreased against a 108 CFU/mL inoculum, whereas no inoculum effect was observed with M. haemolytica. Marbofloxacin activity was also tested in a lung infection model with immunocompromised mice intratracheally infected with 109 CFU of each bacteria. At the same dose, the clinical and bacteriological outcomes were much better for mice infected with M. haemolytica than for those infected with P. multocida. Moreover, bacteriological eradication was obtained with a lower marbofloxacin dose for mice infected with M. haemolytica. Our results suggest that the differential in vivo marbofloxacin efficacy observed with the two bacterial species of similar MIC could be explained by a differential inoculum effect. Consequently, MICs determined on 105 CFU inocula were not predictive of the differences in antibiotic efficacies against high bacterial inocula of closely related bacterial strains. These results could stimulate further investigations on bacterial species-specific antibiotic doses in a clinical setting.

  5. Speedy Mic's Photograph

    Science.gov (United States)

    2007-12-01

    Using observations from ESO's VLT, astronomers were able for the first time to reconstruct the site of a flare on a solar-like star located 150 light years away. The study of this young star, nicknamed 'Speedy Mic' because of its fast rotation, will help scientists better understand the youth of our Sun. ESO PR Photo 53/07 ESO PR Photo 53/07 Mapping Spots on Speedy Mic The astronomers [1] observed the star BO Microscopii [2] during two consecutive nights in October 2006, simultaneously with the UVES spectrograph on ESO's Very Large Telescope and ESA's XMM-Newton X-ray satellite. Using a technique called 'Doppler imaging' [3], the astronomers reconstructed images of the surface of the star, detecting the presence of several spots. A few are near the visible pole, while most spots are asymmetrically distributed at mid-latitudes. "The image we could secure of Speedy Mic is, given its distance, a real achievement, that allows us to localise for the first time ever the source of a flare and its surrounding," says Uwe Wolter, lead author of the paper relating the discovery. The X-ray observations indeed identified several flares, which are sudden and vast releases of energy. For one of them, the astronomers could pinpoint its origin on the surface of the star. The flare, lasting about 4 hours, was a hundred times more energetic than a large solar flare and considerably larger than solar coronal loops. The surprising finding, the team says, was the location of the flare. Contrary to our Sun, the site of the observed flare does not correspond to the detected spots [4]. "Interestingly, the flare occurs on a rather inconspicuous portion of the star's surface, away from the main concentration of activity in terms of dark spots," explains Wolter. Speedy Mic is a very young star: with an age of only about 30 million years, it is roughly 150 times younger than the Sun. "It is very likely that our young Sun was a fast rotator as well," says Wolter. "Studying Speedy Mic is thus

  6. How to choose an appropriate transfer function in designing a simplest ANN to solve specific problems

    Institute of Scientific and Technical Information of China (English)

    吴佑寿

    1996-01-01

    How to irmrporate certain constraints known a prion into the transfer function to redure thenumber of hidden units of an MFNN in solving some specific probems is disussed. The N-bit parity andsymmetrical problems are used as examples and the derivation of the transfer function based on the a privriknowledge of the input patterns is given. It is shown that by use of the method proposed, only onc hiddenunit is needed in solving the parity and symmetry test problems.

  7. Choosing disinfectants.

    Science.gov (United States)

    Fraise, A P

    1999-12-01

    Disinfectant choice is an important part of the role of the infection control team. Its importance has increased due to concern over transmission of blood-borne viruses and the need to identify alternatives to gluteraldehyde. Factors to be taken into account when choosing disinfectants include compliance with COSHH regulations, user acceptability, instrument compatibility and antimicrobial activity. Compounds vary in their suitability for different uses and an agent's properties must be fully evaluated before adopting it for a particular purpose. This review outlines the main properties that need to be established and covers the major characteristics of main classes of disinfectants. PMID:10658801

  8. The frequent occurrence of MIC

    Energy Technology Data Exchange (ETDEWEB)

    Graff, Matthias [Gesellschaft fuer Technische Mikrobiologie und Hygieneueberwachung - Dr. Graff und Partner, Stadtweg 9, D-38176 Wendeburg (Germany); Neubert, Volkmar [Institut fuer Materialpruefung und Werkstofftechnik Dr. Doelling und Dr. Neubert GmbH, Freiberger Strasse 1, D-38678 Clausthal-Zellerfeld (Germany)

    2004-07-01

    Microbial induced corrosion (MIC) is not as rare as many materials scientist and corrosion practitioners do believe. It is not an exotic and scarce event, but can be found frequently in many fields of corrosion research, provided that it is looked for. The reason for the relatively few descriptions of MIC cases seems to be the fact, that the microbiological approach is not widely known and applied in the world of materials science. MIC is not so much a corrosion mechanism on its own, but it enhances the corrosion rates of the 'normal' mechanisms to such an extent, that in some cases 'incredible' fast corrosion progress can be observed. The reason is the microorganisms' function as bio-catalysts: Chemical reactions, which are very slow under normal chemical conditions can be highly accelerated by living organisms. Besides that, several microorganisms do produce very corrosive substances which in natural environments do not occur without the activity of microorganisms, e. g. sulfuric or nitric acid. We want to point out, that it can be very worthy to take microbial induced corrosion into account. MIC is not the general answer for all unsolved corrosion problems, but to think about it helps in many corrosion cases as the authors had to experience. The initial indication for the presence of MIC are markedly increased corrosion rates. In the following, some of our 'lessons' are presented as short case studies: Two of them deal with steel corrosion characterized by increased corrosion rates. The third example presents corrosion damage of aluminium structures, where from a technical point of view corrosion was not expected, least of all microbial induced corrosion. (authors)

  9. Experiences on MIC monitoring by electrochemical techniques

    DEFF Research Database (Denmark)

    Cristiani, P.; Perboni, G.; Hilbert, Lisbeth Rischel;

    2002-01-01

    Some results of practical experiences on the performances of electrochemical and electric MIC monitoring techniques, coming from the discussion in the Brite-Euram thematic network "MIC of industrial materials", are presented in this paper.......Some results of practical experiences on the performances of electrochemical and electric MIC monitoring techniques, coming from the discussion in the Brite-Euram thematic network "MIC of industrial materials", are presented in this paper....

  10. MicNeSs: genotyping microsatellite loci from a collection of (NGS) reads.

    Science.gov (United States)

    Suez, Marie; Behdenna, Abdelkader; Brouillet, Sophie; Graça, Paula; Higuet, Dominique; Achaz, Guillaume

    2016-03-01

    Microsatellites are widely used in population genetics to uncover recent evolutionary events. They are typically genotyped using capillary sequencer, which capacity is usually limited to 9, at most 12 loci for each run, and which analysis is a tedious task that is performed by hand. With the rise of next-generation sequencing (NGS), a much larger number of loci and individuals are available from sequencing: for example, on a single run of a GS Junior, 28 loci from 96 individuals are sequenced with a 30X cover. We have developed an algorithm to automatically and efficiently genotype microsatellites from a collection of reads sorted by individual (e.g. specific PCR amplifications of a locus or a collection of reads that encompass a locus of interest). As the sequencing and the PCR amplification introduce artefactual insertions or deletions, the set of reads from a single microsatellite allele shows several length variants. The algorithm infers, without alignment, the true unknown allele(s) of each individual from the observed distributions of microsatellites length of all individuals. MicNeSs, a python implementation of the algorithm, can be used to genotype any microsatellite locus from any organism and has been tested on 454 pyrosequencing data of several loci from fruit flies (a model species) and red deers (a nonmodel species). Without any parallelization, it automatically genotypes 22 loci from 441 individuals in 11 hours on a standard computer. The comparison of MicNeSs inferences to the standard method shows an excellent agreement, with some differences illustrating the pros and cons of both methods.

  11. High-performance computing on the Intel Xeon Phi how to fully exploit MIC architectures

    CERN Document Server

    Wang, Endong; Shen, Bo; Zhang, Guangyong; Lu, Xiaowei; Wu, Qing; Wang, Yajuan

    2014-01-01

    The aim of this book is to explain to high-performance computing (HPC) developers how to utilize the Intel® Xeon Phi™ series products efficiently. To that end, it introduces some computing grammar, programming technology and optimization methods for using many-integrated-core (MIC) platforms and also offers tips and tricks for actual use, based on the authors' first-hand optimization experience.The material is organized in three sections. The first section, "Basics of MIC", introduces the fundamentals of MIC architecture and programming, including the specific Intel MIC programming environment

  12. Prevention for possible microbiologically influenced corrosion (MIC) in RHLWE flush water system

    Energy Technology Data Exchange (ETDEWEB)

    Hsu, T.C.; Jenkins, C.F.

    1995-07-10

    This report is in response to the request to provide a recommendation for the prevention of possible microbiologically influenced corrosion (MIC) for the RHLWE (Replacement High-Level Waste Evaporator) flush water (FW) system. The recent occurrences of MIC at DWPF prompted HLWE to evaluate the possibility of MIC occurring in this 304L stainless steel RHLWE flush water system. Concern was heightened by the fact that the well water used and the other conditions at H-Tank Farm are similar to those at DWPF. However, only one known leak has occurred in the existing 304L evaporator flush water systems in either tank farm (in 1H system), and no MIC Corrosion has been confirmed in the tank farm area. The design of the RHLWE flush water system (completed long before the occurrence of MIC at DWPF) was modeled after the existing evaporator flush water systems and did not specifically include MIC prevention considerations. Therefore, MIC prevention was not specifically considered during the design phase of this flush water system. The system is presently being installed. After an extensive evaluation, a task team concluded that the best biocide to prevent the occurrence of MIC would be NaOH at fairly low concentration. Sodium hydroxide (NaOH) is optimal in this application, because of its effectiveness, low cost, and familiarity to the Operations personnel (see Appendix A). However, it is the opinion of the task group that application should be withheld until MIC corrosion is demonstrated in the system.

  13. Choosing Safe Toys

    Science.gov (United States)

    ... Things to Know About Zika & Pregnancy Choosing Safe Toys KidsHealth > For Parents > Choosing Safe Toys Print A ... can contribute to hearing damage. continue The Right Toys at the Right Ages Always read labels to ...

  14. NICHD Microscopy and Imaging Core (MIC)

    Data.gov (United States)

    Federal Laboratory Consortium — The NICHD Microscopy and Imaging Core (MIC) is designed as a multi-user research facility providing training and instrumentation for high resolution microscopy and...

  15. B-MIC: An Ultrafast Three-Level Parallel Sequence Aligner Using MIC.

    Science.gov (United States)

    Cui, Yingbo; Liao, Xiangke; Zhu, Xiaoqian; Wang, Bingqiang; Peng, Shaoliang

    2016-03-01

    Sequence alignment is the central process for sequence analysis, where mapping raw sequencing data to reference genome. The large amount of data generated by NGS is far beyond the process capabilities of existing alignment tools. Consequently, sequence alignment becomes the bottleneck of sequence analysis. Intensive computing power is required to address this challenge. Intel recently announced the MIC coprocessor, which can provide massive computing power. The Tianhe-2 is the world's fastest supercomputer now equipped with three MIC coprocessors each compute node. A key feature of sequence alignment is that different reads are independent. Considering this property, we proposed a MIC-oriented three-level parallelization strategy to speed up BWA, a widely used sequence alignment tool, and developed our ultrafast parallel sequence aligner: B-MIC. B-MIC contains three levels of parallelization: firstly, parallelization of data IO and reads alignment by a three-stage parallel pipeline; secondly, parallelization enabled by MIC coprocessor technology; thirdly, inter-node parallelization implemented by MPI. In this paper, we demonstrate that B-MIC outperforms BWA by a combination of those techniques using Inspur NF5280M server and the Tianhe-2 supercomputer. To the best of our knowledge, B-MIC is the first sequence alignment tool to run on Intel MIC and it can achieve more than fivefold speedup over the original BWA while maintaining the alignment precision.

  16. The triple system AT Mic AB + AU Mic in the β Pictoris association

    Science.gov (United States)

    Messina, Sergio; Leto, Giuseppe; Pagano, Isabella

    2016-09-01

    Equal-mass stars in young open clusters and loose associations exhibit a wide spread of rotation periods, which likely originates from differences in the initial rotation periods and in the primordial disc lifetimes. We want to explore if the gravitational effects by nearby companions may play an additional role in producing the observed rotation period spread, as well as, the role that magnetic activity may also play. We measure the photometric rotation periods of components of multiple stellar systems and look for correlations of the period differences among the components to their reciprocal distances. In this paper, we analyzed the triple system AU Mic + AT Mic A&B in the 25± 3-Myr β Pictoris association. We have retrieved from the literature the rotation period of AU Mic ({P} = 4.85 d) and measured from photometric archival data the rotation periods of both components of AT Mic ({P} = 1.19 d and {P} = 0.78 d) for the first time. Moreover, we detected a high rate of flare events from AT Mic. Whereas the distant component AU Mic has evolved rotationally as a single star, the A and B components of AT Mic, separated by ˜ 27 AU, exhibit a rotation rate a factor 5 larger than AU Mic. Moreover, the A and B components, despite have about equal mass, show a significant difference (˜ 40 %) between their rotation periods. A possible explanation is that the gravitational forces between the A and B components of AT Mic (that are a factor ˜ 7.3× 106 more intense than those between AU Mic and AT Mic) have enhanced the dispersal of the AT Mic primordial disc, shortening its lifetime and the disc-locking phase duration, making the component A and B of AT Mic to rotate faster than the more distant AU Mic. We suspect that a different level of magnetic activity between the A and B components of AT Mic may be the additional parameter responsible for the difference between their rotation periods.

  17. To Choose or Not to Choose Science

    DEFF Research Database (Denmark)

    Holmegaard, Henriette Tolstrup; Madsen, Lene Møller; Ulriksen, Lars

    2014-01-01

    In the literature, there is a general concern that a less number of students choose to study science, technology, engineering or mathematics (STEM). This paper presents results from a Danish longitudinal study which examines students’ choice of whether or not to continue studying STEM after upper......-secondary school. In particular, this study focuses on students who held an STEM subject as one of their favourite subjects at secondary educational level, but who chose not to study STEM at the tertiary level. This paper explores how students’ perceptions of STEM relate to their identity work. The data used...

  18. Choosing the best doctor

    Science.gov (United States)

    ... gov/ency/article/002069.htm Choosing the best doctor To use the sharing features on this page, ... patient care methods. Prescriber Checkup and Dollars for Doctors These pages are run by ProPublica, a nonprofit ...

  19. Choosing Nutrient Dense Foods

    Medline Plus

    Full Text Available ... of butter crackers, bacon, coffee cake ] Some older adults answer the question this way: Richard: In the ... is okay. Narrator: Richard and Gloria are older adults who choose to eat nutrient-dense foods, foods ...

  20. Choosing Nutrient Dense Foods

    Medline Plus

    Full Text Available ... wholegrain pastas available at the grocery store. Narrator: One way to get fiber is by eating healthy ... you to choose between closely related foods, the one that is the best nutritional value for you. ...

  1. Choosing Nutrient Dense Foods

    Medline Plus

    Full Text Available ... Bales, Ph.D., R.D.: So what nutrient density does is allow you to choose between closely ... enough calories for the day, either way, nutrient density is a very important concept.

  2. The triple system AT Mic AB + AU Mic in the beta Pictoris Association

    CERN Document Server

    Messina, Sergio; Pagano, Isabella

    2016-01-01

    Equal-mass stars in young open clusters and loose associations exhibit a wide spread of rotation periods, which likely originates from differences in the initial rotation periods and in the primordial disc lifetimes. We want to explore if the gravitational effects by nearby companions may play an additional role in producing the observed rotation period spread. We measure the photometric rotation periods of components of multiple stellar systems and look for correlations of the period differences among the components to their reciprocal distances. In this paper, we analysed the triple system AU Mic + AT Mic A&B in the 25-Myr beta Pictoris Association. We have retrieved from the literature the rotation period of AU Mic (P = 4.85d) and measured from photometric archival data the rotation periods of both components of AT Mic (P = 1.19d and P = 0.78d) for the first time. Moreover, we detected a high rate of flare events from AT Mic. Whereas the distant component AU Mic has evolved rotationally as a single sta...

  3. Identification of host proteins, Spata3 and Dkk2, interacting with Toxoplasma gondii micronemal protein MIC3.

    Science.gov (United States)

    Wang, Yifan; Fang, Rui; Yuan, Yuan; Pan, Ming; Hu, Min; Zhou, Yanqin; Shen, Bang; Zhao, Junlong

    2016-07-01

    As an obligate intracellular protozoan, Toxoplasma gondii is a successful pathogen infecting a variety of animals, including humans. As an adhesin involving in host invasion, the micronemal protein MIC3 plays important roles in host cell attachment, as well as modulation of host EGFR signaling cascade. However, the specific host proteins that interact with MIC3 are unknown and the identification of such proteins will increase our understanding of how MIC3 exerts its functions. This study was designed to identify host proteins interacting with MIC3 by yeast two-hybrid screens. Using MIC3 as bait, a library expressing mouse proteins was screened, uncovering eight mouse proteins that showed positive interactions with MIC3. Two of which, spermatogenesis-associated protein 3 (Spata3) and dickkopf-related protein 2 (Dkk2), were further confirmed to interact with MIC3 by additional protein-protein interaction tests. The results also revealed that the tandem repeat EGF domains of MIC3 were critical in mediating the interactions with the identified host proteins. This is the first study to show that MIC3 interacts with host proteins that are involved in reproduction, growth, and development. The results will provide a clearer understanding of the functions of adhesion-associated micronemal proteins in T. gondii.

  4. Choosing for learning objects

    NARCIS (Netherlands)

    Schoonenboom, Judith; Emans, Bruno; Meijer, Joost

    2006-01-01

    Choosing for learning objects discusses eight educational ambitions and the possible roles of learning objects in realising these ambitions. The eight educational ambitions are: (1) Creating independent learning pathways, for example for lifelong learners; (2) Making education more flexible; (3) Res

  5. Choosing for learning objects

    OpenAIRE

    Schoonenboom, Judith; Emans, Bruno; Meijer, Joost

    2006-01-01

    Choosing for learning objects discusses eight educational ambitions and the possible roles of learning objects in realising these ambitions. The eight educational ambitions are: (1) Creating independent learning pathways, for example for lifelong learners; (2) Making education more flexible; (3) Responding to differences between students; (4) The joint development of learning materials together with other institutions or external parties; (5) Attuning to professional practice; (6) Attuning to...

  6. Choosing health, constrained choices.

    Science.gov (United States)

    Chee Khoon Chan

    2009-12-01

    In parallel with the neo-liberal retrenchment of the welfarist state, an increasing emphasis on the responsibility of individuals in managing their own affairs and their well-being has been evident. In the health arena for instance, this was a major theme permeating the UK government's White Paper Choosing Health: Making Healthy Choices Easier (2004), which appealed to an ethos of autonomy and self-actualization through activity and consumption which merited esteem. As a counterpoint to this growing trend of informed responsibilization, constrained choices (constrained agency) provides a useful framework for a judicious balance and sense of proportion between an individual behavioural focus and a focus on societal, systemic, and structural determinants of health and well-being. Constrained choices is also a conceptual bridge between responsibilization and population health which could be further developed within an integrative biosocial perspective one might refer to as the social ecology of health and disease.

  7. ENVIRONMENTALLY BENIGN MITIGATION OF MICROBIOLOGICALLY INFLUENCED CORROSION (MIC)

    Energy Technology Data Exchange (ETDEWEB)

    J. Robert Paterek; Gemma Husmillo; Amrutha Daram; Vesna Trbovic; Teri Storino

    2003-04-01

    The overall program objective is to develop and evaluate environmentally benign agents or products that are effective in the prevention, inhibition, and mitigation of microbially influenced corrosion (MIC) in the internal surfaces of metallic natural gas pipelines. The goal is to develop one or more environmentally benign (a.k.a. ''green'') products that can be applied to maintain the structure and dependability of the natural gas infrastructure. The technical approach for this quarter includes the application of new methods of Capsicum sp. (pepper) extraction by soxhlet method and analysis of a new set of extracts by thin layer chromatography (TLC) and high performance liquid chromatography (HPLC); isolation and cultivation of MIC-causing microorganisms from corroded pipeline samples; and evaluation of antimicrobial activities of the old set of pepper extracts in comparison with major components of known biocides and corrosion inhibitors. Twelve new extracts from three varieties of Capsicum sp. (Serrano, Habanero, and Chile de Arbol) were obtained by soxhlet extraction using 4 different solvents. Results of TLC done on these extracts showed the presence of capsaicin and some phenolic compounds, while that of HPLC detected capsaicin and dihydrocapsaicin peaks. More tests will be done to determine specific components. Additional isolates from the group of heterotrophic, acid-producing, denitrifying and sulfate-reducing bacteria were obtained from the pipeline samples submitted by gas companies. Isolates of interest will be used in subsequent antimicrobial testing and test-loop simulation system experiments. Results of antimicrobial screening of Capsicum sp. extracts and components of known commercial biocides showed comparable activities when tested against two strains of sulfate-reducing bacteria.

  8. Choosing the Right Systems Integration

    Directory of Open Access Journals (Sweden)

    Péči Matúš

    2014-12-01

    Full Text Available The paper examines systems integration and its main levels at higher levels of control. At present, the systems integration is one of the main aspects participating in the consolidation processes and financial flows of a company. Systems Integration is a complicated emotionconsuming process and it is often a problem to choose the right approach and level of integration. The research focused on four levels of integration, while each of them is characterized by specific conditions. At each level, there is a summary of recommendations and practical experience. The paper also discusses systems integration between the information and MES levels. The main part includes user-level integration where we describe an example of such integration. Finally, we list recommendations and also possible predictions of the systems integration as one of the important factors in the future.

  9. How couples choose vasectomy.

    Science.gov (United States)

    Schehl, M

    1997-01-01

    A study conducted by AVSC International between 1992 and 1995 found that couples around the world go through a highly similar decision-making process when they choose vasectomy as their family planning methods. Study findings are based upon in-depth, qualitative interviews with couples using vasectomy in Bangladesh, Mexico, Kenya, and Rwanda, where the prevalence of vasectomy is relatively low, and Sri Lanka and the US, where it is relatively high. 218 separate interviews were conducted with male and female partners. Concerns about the woman's health were cited by respondents in each country as reasons to cease childbearing and to opt for vasectomy as the means to achieving that end. Also, almost all respondents mentioned varying degrees of financial hardship as contributing to their decision to end childbearing. These findings highlight the concept of partnership in relationships and family planning decision-making, and demonstrate the importance of going beyond traditional stereotypes about gender roles in decision-making. Social influences and the potential risks of using other forms of contraception also contributed to the choice of using vasectomy. The decision-making process and lessons learned are discussed.

  10. Me Nuh Choose None

    Directory of Open Access Journals (Sweden)

    Christina Cooke

    2013-05-01

    Full Text Available Drawing on textual modes of fictional representation first valorised then disseminated by British imperialists, this story appropriates then abrogates Eurocentric ideals of normative creative expression. By appropriating the rhythm of lyrical poetry into the descriptions of this fictionalized Jamaica as well as the structure of modernist prose into Akúa’s psychical shift from colonial subject to postcolonial agent, “Me Nuh Choose None” inverts these narrative conventions historically used to systematize and exclude in order to puncture the imperious myth that complex writing in English primarily concerns itself with gratifying the colonial centre. Moreover, by treating the textual approximations of the Jamaican storyteller Miss Lou’s oral folktales with equal depth and sophistication as the instances of alliteration and onomatopoeia, this story abrogates the autocratic standard of “proper” spelling and pronunciation so as to textually privilege Jamaican folklore using the literariness usually reserved for Western texts. The effect is a form of fiction that acknowledges the dense matrix of cultural and colonial systems English writing exists within, while simultaneously gesturing between and beyond these systems to the linguistic interstices of postcolonial liminality.

  11. Cephalosporin MIC creep among gonococci: time for a pharmacodynamic rethink?

    NARCIS (Netherlands)

    Chisholm, S.A.; Mouton, J.W.; Lewis, D.A.; Nichols, T.; Ison, C.A.; Livermore, D.M.

    2010-01-01

    BACKGROUND: Gonorrhoea has been among the easiest infections to cure with antibiotics. Nevertheless, emerging resistance has driven repeated treatment shifts. Decreased cephalosporin susceptibility is now being reported. We examined cephalosporin MIC trends for Neisseria gonorrhoeae in the UK and un

  12. Development of biological coal gasification (MicGAS Process)

    Energy Technology Data Exchange (ETDEWEB)

    1992-07-28

    This report describes progress on three fronts of the project. First in studies to elucidate optimal growing conditions for the consortia of coal degraders employed indicates that best growth occurs with 0. 2% w/v Shefton T. Secondly in comparing the biodegradative properties of the coal degraders, isolates identified as Mic-1 and Mic-4 were the best performers. And lastly bioreactors studies in batch mode are related.

  13. Choosing the right technology

    DEFF Research Database (Denmark)

    Milan, Christian; Nielsen, Mads Pagh; Bojesen, Carsten

    2014-01-01

    the planning process. The methodology allows for specifying a level of Net Zero Energy Building (Net ZEB) performance to investigate cost reductions when allowing shares of fossil fuel consumption. The outcome is an optimal supply technology combination and optimal installed capacities in terms of the overall......The use of renewable energy sources (RES) has continuously increased throughout the last decade. In the residential building sector the trend goes towards energy supply systems based on multiple RES. This is mainly due to political requirements, governmental subsidies and fuel price development...... costs including system installation and operating expenses. The approach is applied to a case study of a residential single family house under Danish conditions. It delivers rapidly site-specific solutions and can easily be used as an extension for common building energy simulation software. In the case...

  14. Context and Word Choosing in Translation

    Institute of Scientific and Technical Information of China (English)

    张向阳

    2007-01-01

    This paper has a discussion on context in relation to translation,and elaborates with examples the important role context plays in helping translators to choose the right word in the line with a specific context. Context here does not only refer to the linguistic context,but also the non-linguistic context,which can be further subcategorized as situational and cultural context.

  15. Operational measures for the mitigation of MIC [microbiologically influenced corrosion

    International Nuclear Information System (INIS)

    Although entitled Operational Measure, this section of the workshop encompasses aspects of mitigating MIC by controlling the hydraulic characteristics of a system. In order for operational considerations outside of the chemical treatment program to be effective, the system must be designed, constructed or modified, and maintained with MIC in mind. Since other papers in these proceedings discuss in detail the proper selection of materials, chemical treatments and detection of monitoring techniques, this paper is limited to quidelines for mitigating MIC and its effects by the mechanical design, maintenance and operation of the system. The key concept behind this philosophy is the synergistic relationships among microbes and among microbes and larger biofouling organisms. If the slime formers or other marine organisms can be prevented from attaching to the components, conducive environments for attack by other species is avoided

  16. The BinaMIcS project: binarity and magnetism

    Science.gov (United States)

    Neiner, C.; Alecian, E.

    2013-02-01

    We present the BinaMIcS project, its goals and the first BinaMIcS spectropolarimetric observations obtained with Narval at TBL and ESPaDOnS at CFHT: dedicated time-series for targeted hot and cool close double-line spectroscopic (SB2) binaries and a survey of hot close SB2 binaries. The very first results are also presented. In particular, our first survey observations seem to show a lack of magnetic fields in hot close binaries compared to single stars.

  17. The BinaMIcS project: binarity and magnetism

    OpenAIRE

    Neiner, C.; Alecian, E.; collaboration, the BinaMIcS

    2013-01-01

    We present the BinaMIcS project, its goals and the first BinaMIcS spectropolarimetric observations obtained with Narval at TBL and ESPaDOnS at CFHT: dedicated time-series for targeted hot and cool close double-line spectroscopic (SB2) binaries and a survey of hot close SB2 binaries. The very first results are also presented. In particular, our first survey observations seem to show a lack of magnetic fields in hot close binaries compared to single stars.

  18. Development of Biological Coal Gasification (MicGAS Process). Topical report, July 1991--February 1993

    Energy Technology Data Exchange (ETDEWEB)

    Srivastava, K.C.

    1993-06-01

    Laboratory and bench scale reactor research carried out during the report period confirms the feasibility of biomethanation of Texas lignite (TxL) and some other low-rank coals to methane by specifically developed unique anaerobic microbial consortia. The data obtained demonstrates specificity of a particular microbial consortium to a given lignite. Development of a suitable microbial consortium is the key to the success of the process. The Mic-1 consortium was developed to tolerate higher coal loadings of 1 and 5% TxL in comparison to initial loadings of 0.01% and 0.1% TxL. Moreover, the reaction period was reduced from 60 days to 14 to 21 days. The cost of the culture medium for bioconversion was reduced by studying the effect of different growth factors on the biomethanation capability of Mic-1 consortium. Four different bench scale bioreactor configurations, namely Rotating Biological Contactor (RBC), Upflow Fluidized Bed Reactor (UFBR), Trickle Bed Reactor (TBR), and Continuously Stirred Tank Reactor (CSTR) were evaluated for scale up studies. Preliminary results indicated highest biomethanation of TxL by the Mic-1 consortium in the CSTR, and lowest in the trickle bed reactor. However, highest methane production and process efficiency were obtained in the RBC.

  19. Gradient Plate for Hicomb Minimum Inhibitory Concentration (MIC Test

    Directory of Open Access Journals (Sweden)

    Fatemi Motlagh M

    2011-01-01

    Full Text Available Bakground and objectives: "The comb antibiotic sensitivity test" is a quick,reliable and cost effective method to determine the susceptibility of bacteriato different antibiotics. The purpose of this study is to design a plate that iseasy and quick to use, and enable to be interpreted easily without the need formeasurement of the margins with a ruler.Material and Methods: First, Clinical and Laboratory Standards Institutedata about the maximum growth inhibitory haloes formed with antibioticsand various micro-organisms were statistically examined and determinedthat the most (99.7% zone of inhibition growth is formed in the range of 42mm. Accordingly, the obtained number (42 mm and conventional plate size(100 mm used for testing sensitivity were punched into Solid workssoftware which was used to determine the best place of strip and shoulderplates. After that the efficacy this media were examined by determination ofMIC Staphylococcus aureus and Klebsiella pneumonia, non-graded andgraded plate shoulders were searched and compared.Results: Has been placed two combs MIC in a plate in this method anddidn’t create growth inhibitory haloes interferences. Obtained MIC forNitrofurantoin( 10 μg/ml , Amikacin(0.5 μg/ml, Gentamicin(1 μg/ml , andAmoxicillin (0.5 μg/ml against S.aureus , MIC Nalidicsic Acid, Amikcin,Gentamicin and Nitrofurantoin against K.pneumonia was 0.1, 0.5, 0.5 and 10μg/ml ,respectively.Conclusion:The comparison between this new innovative method andstandard methods (Clinical Laboratory Standards Institute - CLSI shows thatthere a marked reduction in the interference of antibiotic therapy and willalso reduce time of interpretation.Key words: Plate, Antibiogram Comb, MIC, Antibiotics, Drug resistance

  20. Children and (Five Choose Two).

    Science.gov (United States)

    Zvonkin, Alexander K.

    1993-01-01

    Recounts a teacher's experiences with a small group of elementary school students as they explore different forms of the combinatorics problem of choosing two out of five objects. Describes how students examine the connections between the problems and a proof of the relationship. (MDH)

  1. Choosing a Senior Living Community

    Science.gov (United States)

    ... that be an independent living community, assisted living community or nursing home. However, there are numerous signs that a ... Download the Guide to Choosing an Assisted Living Community checklist. ... living, assisted living, nursing homes, etc.-it's important to assess your or ...

  2. Mic13 Is Essential for Formation of Crista Junctions in Mammalian Cells

    Science.gov (United States)

    Anand, Ruchika; Strecker, Valentina; Urbach, Jennifer; Wittig, Ilka; Reichert, Andreas S.

    2016-01-01

    Mitochondrial cristae are connected to the inner boundary membrane via crista junctions which are implicated in the regulation of oxidative phosphorylation, apoptosis, and import of lipids and proteins. The MICOS complex determines formation of crista junctions. We performed complexome profiling and identified Mic13, also termed Qil1, as a subunit of the MICOS complex. We show that MIC13 is an inner membrane protein physically interacting with MIC60, a central subunit of the MICOS complex. Using the CRISPR/Cas method we generated the first cell line deleted for MIC13. These knockout cells show a complete loss of crista junctions demonstrating that MIC13 is strictly required for the formation of crista junctions. MIC13 is required for the assembly of MIC10, MIC26, and MIC27 into the MICOS complex. However, it is not needed for the formation of the MIC60/MIC19/MIC25 subcomplex suggesting that the latter is not sufficient for crista junction formation. MIC13 is also dispensable for assembly of respiratory chain complexes and for maintaining mitochondrial network morphology. Still, lack of MIC13 resulted in a moderate reduction of mitochondrial respiration. In summary, we show that MIC13 has a fundamental role in crista junction formation and that assembly of respiratory chain supercomplexes is independent of mitochondrial cristae shape. PMID:27479602

  3. A low power MICS band phase-locked loop for high resolution retinal prosthesis.

    Science.gov (United States)

    Yang, Jiawei; Skafidas, Efstratios

    2013-08-01

    Ultra low power dissipation is essential in retinal prosthesis and many other biomedical implants. Extensive research has been undertaken in designing low power biomedical transceivers, however to date, most effort has been focused on low frequency inductive links. For higher frequency, more robust and more complex applications, such as Medical Implant Communication Service (MICS) band multichannel transceivers, power consumption remains high. This paper explores the design of micro-power data links at 400 MHz for a high resolution retinal prosthesis. By taking advantage of advanced small geometry CMOS technology and precise transistor-level modeling, we successfully utilized subthreshold FET operation, which has been historically limited to low frequency circuits due to the inadequate transistor operating speed in and near weak inversion; we have implemented a low power MICS transceiver. Particularly, a low power, MICS band multichannel phase-locked loop (PLL) that employs a subthreshold voltage controlled oscillator (VCO) and digital synchronous dividers has been implemented on a 65-nm CMOS. A design methodology is presented in detail with the demonstration of EKV model parameters extraction. This PLL provides 600- mVpp quadrature oscillations and exhibits a phase noise of -102 dBc/Hz at 200-kHz offset, while only consuming 430- μW from a 1-V supply. The VCO has a gain (KVCO) of 12 MHz/V and is designed to operate in the near-weak inversion region and consumes 220- μA DC current. The designed PLL has a core area of 0.54 mm(2). It satisfies all specifications of MICS band operation with the advantage of significant reduction in power which is crucial for high resolution retinal prosthesis.

  4. Macrophage Inhibitory Cytokine-1 (MIC-1 as A Biomarker for Diagnosis 
and Prognosis of Stage I-II Non-small Cell Lung Cancer

    Directory of Open Access Journals (Sweden)

    Yuning LIU

    2016-04-01

    Full Text Available Background and objective Increased macrophage inhibitory cytokine-1 (MIC-1, member of transforming growth factor-β (TGF-β superfamily, was found in patients serum with epithelial tumors. Therefore, our aim was to delineate the diagnostic and prognostic value of serum MIC-1 in patients with stage I-II non-small cell lung cancer (NSCLC. Methods A total of 152 consecutive patients with stage I–II NSCLC were prospectively enrolled and underwent follow up after total resection of tumor. Serum MIC-1 level was detected in lung cancer patients by ELISA, 48 benign pulmonary disease patients and 105 healthy controls, and was correlated with clinical features and prognosis of patients. Results The level of MIC-1 of NSCLC patients was significantly higher than that of controls (P<0.001 and benign pulmonary disease patients (P<0.001. A threshold of 1,000 pg/mL could be used to diagnose early-stage NSCLC with 70.4% sensitivity and 99.0% specificity. The level of MIC-1 was associated with elder age (P=0.001, female (P=0.03 and T2 (P=0.022. A threshold of 1,465 pg/mL could identify patients with early poor outcome with 72.2% sensitivity and 66.1% specificity. The overall 3-year survival rate in patients with high level of MIC-1 (≥1,465 pg/mL was significantly lower than that of patients with low MIC-1 level (77.6% vs 94.8%. Multivariable Cox regression revealed that a high level of MIC-1 was an independent risk factor for compromised overall survival (HR=3.37, 95%CI: 1.09-10.42, P=0.035. Conclusion High level of serum MIC-1 could be served as a potential biomarker for diagnosis and poorer outcome in patients with early-stage NSCLC.

  5. Aprender a narrar con el cómic

    OpenAIRE

    Prado Aragonés, Josefina

    1995-01-01

    Proponemos la utilización del cómic en el aula como recurso didáctico para iniciar a nuestros alumnos en la lectura crítica de la imagen y en el conocimiento del género narrativo. Uno de los medios de comunicación más atractivo para niños y jóvenes y más característico de la cultura contemporánea, denominada «cultura de la imagen», es el cómic. Con este nombre genérico denominamos una serie de publicaciones: tebeos, tiras, historietas gráficas; cuyo tema, inicialmente cómico, pronto se divers...

  6. El cómic feminista: un poco de historia

    OpenAIRE

    Díez Balda, María Antonia

    2011-01-01

    [ES] El cómic es un medio de comunicación popular en el que la narración se resuelve con viñetas dibujadas acompañadas de globos y textos breves. Se editan en serie en tiras o páginas de los periódicos o en cuadernillos independientes y se utilizan para la narración de una anécdota, un chiste o un relato. Los cómics son de fácil lectura, asequibles para todos los públicos, por eso son importantes en la educación infantil, en la transmisión de estereotipos de género y en la propaganda polít...

  7. Equilibria of Generalized Cut and Choose Protocols

    DEFF Research Database (Denmark)

    Branzei, Simina; Caragiannis, Ioannis; Kurokawa, David;

    Classic cake cutting protocols — which fairly allocate a divisible good among agents with heterogeneous preferences — are susceptible to manipulation. Do their strategic outcomes still guarantee fairness? To answer this question we adopt a novel algo rithmic approach, proposing a concrete...... computational model and reasoning about the game-theoretic properties of algorithms that operate in this model. Specifically, we show that each protocol in the class of generalized cut and choose (GCC) protocols — which includes the most important discrete cake cutting protocols — is guaranteed to have...

  8. First experiences with the Intel MIC architecture at LRZ

    OpenAIRE

    Weinberg, Volker; Allalen, Momme

    2013-01-01

    With the rapidly growing demand for computing power new accelerator based architectures have entered the world of high performance computing since around 5 years. In particular GPGPUs have recently become very popular, however programming GPGPUs using programming languages like CUDA or OpenCL is cumbersome and error-prone. Trying to overcome these difficulties, Intel developed their own Many Integrated Core (MIC) architecture which can be programmed using standard parallel programming techniq...

  9. How to choose the route.

    Science.gov (United States)

    Grecu, Irina

    2013-01-01

    Choosing the route for nutrition support delivery is one of the main steps in the algorithm of providing successful nutrition to the critically ill, but it is certainly not an easy process. The rationale should be guided not only by principles like physiology and benefit versus harm, but also by individual patient factors like feasibility, contraindications, predicted versus actual tolerance, and (most important) the timing for starting food delivery. Although oral nutrition is the more physiological route for feeding, it is seldom possible or sufficient in critically ill patients. Enteral nutrition, in the form of tube feeding, remains the best option in the absence of absolute contraindications, but many other factors should be taken into account. These include the importance of starting early and trying to achieve target nutrients delivery early, especially in previously undernourished or in most severely ill patients, as well as the gastrointestinal intolerance present in the majority of critically ill patients. Parenteral nutrition is an alternative route for nutrition delivery when the enteral one is impossible or insufficient. The most common complication when choosing this route is overfeeding, which has been associated with increased complications rate. On the other hand, the most common complication of enteral nutrition is underfeeding, which has also been associated with worse outcome and even increased mortality. Combining enteral with supplemental parenteral nutrition is therefore a rational approach for providing early and adequate nutritional support in the most severely ill patients.

  10. ENVIRONMENTAL BENIGN MITIGATION OF MICROBIOLOGICALLY INFLUENCED CORROSION (MIC)

    International Nuclear Information System (INIS)

    The overall program objective is to develop and evaluate environmental benign agents or products that are effective in the prevention, inhibition, and mitigation of microbially influenced corrosion (MIC) in the internal surfaces of metallic natural gas pipelines. The goal is one or more environmental benign, a.k.a. ''green'' products that can be applied to maintain the structure and dependability of the natural gas infrastructure. The technical approach for this quarter has been to evaluate a number of real world pipeline sources for microbial communities or consortia that form biofilms under laboratory simulations of pipelines. The microorganisms will be identified using classical and molecular microbiological tools and there activities under pipeline simulating conditions will be studied. The quarter saw the collection of the first samples from the industry for isolation of the microorganisms, as well as the design and construction of the laboratory-scale pipeline simulators. Methods development for MIC and biofilm microbial isolations and identification, and laboratory design and construction of pipeline simulators were the only activities. At this stage of the study (first quarter), only preliminary results are available

  11. ENVIRONMENTAL BENIGN MITIGATION OF MICROBIOLOGICALLY INFLUENCED CORROSION (MIC)

    Energy Technology Data Exchange (ETDEWEB)

    J.R. Paterek; G. Husmillo; V. Trbovic

    2003-01-01

    The overall program objective is to develop and evaluate environmental benign agents or products that are effective in the prevention, inhibition, and mitigation of microbially influenced corrosion (MIC) in the internal surfaces of metallic natural gas pipelines. The goal is one or more environmental benign, a.k.a. ''green'' products that can be applied to maintain the structure and dependability of the natural gas infrastructure. The technical approach for this quarter were isolation and cultivation of MIC-causing microorganisms from corroded pipeline samples, optimizing parameters in the laboratory-scale corrosion test loop system and testing the effective concentrations of Capsicum sp. extracts to verify the extent of corrosion on metal coupons by batch culture method. A total of 22 strains from the group of heterotrophic, acid producing, denitrifying and sulfate reducing bacteria were isolated from the gas pipeline samples obtained from Northern Indiana Public Service Company in Trenton, Indiana. They were purified and will be sent out for identification. Bacterial strains of interest were used in antimicrobial screenings and test loop experiments. Parameters for the laboratory-scale test loop system such as gas and culture medium flow rate; temperature; inoculation period; and length of incubation were established. Batch culture corrosion study against Desulfovibrio vulgaris showed that one (S{sub 1}M) out of the four Capsicum sp. extracts tested was effective in controlling the corrosion rate in metal coupons by 33.33% when compared to the untreated group.

  12. ENVIRONMENTAL BENIGN MITIGATION OF MICROBIOLOGICALLY INFLUENCED CORROSION (MIC)

    Energy Technology Data Exchange (ETDEWEB)

    J.R. Paterek

    2002-03-01

    The overall program objective is to develop and evaluate environmental benign agents or products that are effective in the prevention, inhibition, and mitigation of microbially influenced corrosion (MIC) in the internal surfaces of metallic natural gas pipelines. The goal is one or more environmental benign, a.k.a. ''green'' products that can be applied to maintain the structure and dependability of the natural gas infrastructure. The technical approach for this quarter has been to evaluate a number of real world pipeline sources for microbial communities or consortia that form biofilms under laboratory simulations of pipelines. The microorganisms will be identified using classical and molecular microbiological tools and there activities under pipeline simulating conditions will be studied. The quarter saw the collection of the first samples from the industry for isolation of the microorganisms, as well as the design and construction of the laboratory-scale pipeline simulators. Methods development for MIC and biofilm microbial isolations and identification, and laboratory design and construction of pipeline simulators were the only activities. At this stage of the study (first quarter), only preliminary results are available.

  13. ENVIRONMENTALLY BENIGN MITIGATION OF MICROBIOLOGICALLY INFLUENCED CORROSION (MIC)

    Energy Technology Data Exchange (ETDEWEB)

    J. Robert Paterek; Gemma Husmillo

    2002-07-01

    The overall program objective is to develop and evaluate environmental benign agents or products that are effective in the prevention, inhibition, and mitigation of microbially influenced corrosion (MIC) in the internal surfaces of metallic natural gas pipelines. The goal is one or more environmental benign, a.k.a. ''green'' products that can be applied to maintain the structure and dependability of the natural gas infrastructure. Capsicum sp. extracts and pure compounds were screened for their antimicrobial activity against MIC causing bacteria. Studies on the ability of these compounds to dissociate biofilm from the substratum were conducted using microtiter plate assays. Tests using laboratory scale pipeline simulators continued. Preliminary results showed that the natural extracts possess strong antimicrobial activity being comparable to or even better than the pure compounds tested against strains of sulfate reducers. Their minimum inhibitory concentrations had been determined. It was also found that they possess bactericidal properties at minimal concentrations. Biofilm dissociation activity as assessed by microtiter plate assays demonstrated varying degrees of differences between the treated and untreated group with the superior performance of the extracts over pure compounds. Such is an indication of the possible benefits that could be obtained from these natural products. Confirmatory experiments are underway.

  14. Educational Vouchers: Freedom to Choose?

    Directory of Open Access Journals (Sweden)

    Jordan Reel

    2013-12-01

    Full Text Available Milton Friedman is famous for his book title: “Free to Choose.” He also favors educational vouchers, which denies the freedom to choose to people who do not wish to subsidize the education of other people’s children. Thus, he is guilty of a logical contradiction. Why is it important to assess whether Friedman’s views on educational vouchers are logically consistent with his widespread reputation as an advocate of free enterprise, and, thus, freedom to chose? It is important to assess all figures in political economy, and indeed all of scholarship, for logical consistency. It is particularly important to do so in the present case, given the prestige in certain quarters accorded to this Nobel prize-winning economist. We argue in this paper that Friedman’s reputation for logical consistency, and adherence to the philosophy of laissez faire capitalism, are both overblown. Our solution to this challenge is to completely privatize education. Friedman does not advocate that vouchers be utilized for food, clothing or shelter; we see no relevant difference in the case of education. What is the justification of the undertaken topic? This topic is important because education of the next generation is crucial for the upkeep and improvement of society. What is the aim of the present study? It is to demonstrate that the solution offered by M. Friedman and R. Friedman (1990 is highly problematic. What is the methodology used in the study? We quote from this author, and criticize his analysis. What are our main results and conclusions/recommendations? We conclude that the last best hope for the educational industry is laissez faire capitalism, not the mixed economy recommended by Friedman.

  15. Potentials of plasma NGAL and MIC-1 as biomarker(s in the diagnosis of lethal pancreatic cancer.

    Directory of Open Access Journals (Sweden)

    Sukhwinder Kaur

    Full Text Available Pancreatic cancer (PC is lethal malignancy with very high mortality rate. Absence of sensitive and specific marker(s is one of the major factors for poor prognosis of PC patients. In pilot studies using small set of patients, secreted acute phase proteins neutrophil gelatinase associated lipocalin (NGAL and TGF-β family member macrophage inhibitory cytokine-1 (MIC-1 are proposed as most potential biomarkers specifically elevated in the blood of PC patients. However, their performance as diagnostic markers for PC, particularly in pre-treatment patients, remains unknown. In order to evaluate the diagnostic efficacy of NGAL and MIC-1, their levels were measured in plasma samples from patients with pre-treatment PC patients (n = 91 and compared it with those in healthy control (HC individuals (n = 24 and patients with chronic pancreatitis (CP, n = 23. The diagnostic performance of these two proteins was further compared with that of CA19-9, a tumor marker commonly used to follow PC progression. The levels of all three biomarkers were significantly higher in PC compared to HCs. The mean (± standard deviation, SD plasma NGAL, CA19-9 and MIC-1 levels in PC patients was 111.1 ng/mL (2.2, 219.2 U/mL (7.8 and 4.5 ng/mL (4.1, respectively. In comparing resectable PC to healthy patients, all three biomarkers were found to have comparable sensitivities (between 64%-81% but CA19-9 and NGAL had a higher specificity (92% and 88%, respectively. For distinguishing resectable PC from CP patients, CA19-9 and MIC-1 were most specific (74% and 78% respectively. CA19-9 at an optimal cut-off of 54.1 U/ml is highly specific in differentiating resectable (stage 1/2 pancreatic cancer patients from controls in comparison to its clinical cut-off (37.1 U/ml. Notably, the addition of MIC-1 to CA19-9 significantly improved the ability to distinguish resectable PC cases from CP (p = 0.029. Overall, MIC-1 in combination with CA19-9 improved the diagnostic

  16. SUBKLONING DAN ISOLASI GEN PENYANDI MIKRONEMA 3 (MIC-3) Toxoplasma gondii ISOLAT LOKAL

    OpenAIRE

    Diana Indrasanti; Aris Haryanto; Wayan T. Artama

    2011-01-01

    Microneme protein (MIC) is one of proteins that belongs to excretory-secretory antigens (ESAs) of Toxoplasma gondii. Microneme 3 protein (MIC-3) is the protein that plays an important role in the invasion proccess during cell infection as a mediator attachment parasite to the host cell. The aim of this research is to clone mic3 (gene encoding for MIC-3) of T. gondii from local isolate using recombinant DNA technology by cloning mic3 in an expression vector. Deoxyribonucleic acid (DNA) from T....

  17. Determination of MICs of Aminocandin for Candida spp. and Filamentous Fungi▿

    OpenAIRE

    Isham, N.; Ghannoum, M. A.

    2006-01-01

    Candida and Aspergillus spp., as well as other filamentous molds, have increasingly been reported as the causes of severe invasive fungal infections. We evaluated the new echinocandin aminocandin (AMN) for its antifungal activities against a range of fungal pathogens by determination of the MICs for the organisms. The MICs of the comparator drugs amphotericin B, caspofungin, micafungin, and voriconazole were also determined. The MICs of AMN for 25 strains each of non-Candida albicans Candida ...

  18. Comparison of Neisseria gonorrhoeae MICs obtained by Etest and agar dilution for ceftriaxone, cefpodoxime, cefixime and azithromycin.

    Science.gov (United States)

    Gose, Severin; Kong, Carol J; Lee, Yer; Samuel, Michael C; Bauer, Heidi M; Dixon, Paula; Soge, Olusegun O; Lei, John; Pandori, Mark

    2013-12-01

    We evaluated Neisseria gonorrhoeae Etest minimum inhibitory concentrations (MICs) relative to agar dilution MICs for 664 urethral isolates for ceftriaxone (CRO) and azithromycin (AZM), 351 isolates for cefpodoxime (CPD) and 315 isolates for cefixime (CFM). Etest accurately determined CPD, CFM and AZM MICs, but resulted in higher CRO MICs.

  19. Mic Flocks in the Cloud: Harnessing Mobile Ubiquitous Sensor Networks

    Science.gov (United States)

    Garces, M. A.; Christe, A.

    2015-12-01

    Smartphones provide a commercial, off-the-shelf solution to capture, store, analyze, and distribute infrasound using on-board or external microphones (mics) as well as on-board barometers. Free iOS infrasound apps can be readily downloaded from the Apple App Store, and Android versions are in progress. Infrasound propagates for great distances, has low sample rates, and provides a tractable pilot study scenario for open distributed sensor networks at regional and global scales using one of the most ubiquitous sensors on Earth - microphones. Data collection is no longer limited to selected vendors at exclusive prices: anybody on Earth can record and stream infrasound, and the diversity of recording systems and environments is rapidly expanding. Global deployment may be fast and easy (www.redvox.io), but comes with the cost of increasing data volume, velocity, variety, and complexity. Flocking - the collective motion of mobile agents - is a natural human response to threats or events of interest. Anticipating, modeling and harnessing flocking sensor topologies will be necessary for adaptive array and network processing. The increasing data quantity and complexity will exceed the processing capacity of human analysts and most research servers. We anticipate practical real-time applications will require the on-demand adaptive scalability and resources of the Cloud. Cloud architectures for such heterogeneous sensor networks will consider eventual integration into the Global Earth Observation System of Systems (GEOSS).

  20. Coherent Photon Mapping on the Intel MIC Architecture

    Institute of Scientific and Technical Information of China (English)

    Chun-Meng Kang; Lu Wang; Pei Wang; Yan-Ning Xu; Xiang-Xu Meng

    2015-01-01

    Photon mapping is a global illumination algorithm which is composed of two steps: photon tracing and photon searching. During photon searching step, each shading point needs to search the photon-tree to find k-neighbouring photons for reflected radiance estimation. As the number of shading points and the size of photon-tree are dramatically large, the photon searching step is time consuming. We propose a parallel photon searching algorithm by using radiance estimation approach for coherent shading points on the Intelr Many Integrated Core (MIC) Architecture. In order to efficiently use single instruction multiple data (SIMD) units, shading points are clustered by similarity first (every cluster contains 16 shading-points), and an initial neighbouring scope is searched from the photon-tree for each cluster. Then we use 16-wide SIMD units by performing k-NN searching from the initial neighbouring scope for those 16 shading-points in a cluster in parallel. We use the method to simulate some global illumination scenes on Intelr Xeonr processors and Intelr Xeonr PhiTM coprocessors. The comparison results with existing photon mapping techniques indicate that our method gives significant improvement in speed with the same accuracy.

  1. ENVIRONMENTAL BENIGN MITIGATION OF MICROBIOLOGICALLY INFLUENCED CORROSION (MIC)

    Energy Technology Data Exchange (ETDEWEB)

    J.R. Paterek; G. Husmillo

    2002-11-01

    The overall program objective is to develop and evaluate environmental benign agents or products that are effective in the prevention, inhibition, and mitigation of microbially influenced corrosion (MIC) in the internal surfaces of metallic natural gas pipelines. The goal is one or more environmental benign, a.k.a. ''green'' products that can be applied to maintain the structure and dependability of the natural gas infrastructure. The technical approach for this quarter were monitoring the development of Desulfovibrio species biofilm using the continuous flow cell system, evaluation of pepper compounds by microtiter plate assay for mitigating and inhibiting biofilm formation, and testing the effective concentrations to verify the extent of corrosion on metal coupons. Biofilm formation of Desulfovibrio vulgaris and D. desulfuricans was monitored and documented over a 7-day period. The use of a continuous flow cell system proved to be efficient and non-destructive in studying biofilm growth. Live/Dead BacLight was an efficient stain to determine cell viability. The extracts showed 9-25% biofilm formation inhibition against the two organisms, and 18-19% activity in detaching the already formed biofilm. Preliminary data were obtained on the extent of corrosion of metal coupons when treated with pepper extracts as against the untreated ones. Confirmatory tests are underway. A presentation was prepared and give at the US DOE NETL meeting on gas and petroleum infrastructure. The presentation is include as an addition to this report.

  2. Construction of eukaryotic expression plasmid of gene MIC3 of Toxoplasma Gondii and its expression in BHK cells%弓形虫MIC3基因真核表达质粒的构建及其在BHK细胞中的表达

    Institute of Scientific and Technical Information of China (English)

    唐莉娜; 刘涛; 黄雨婷; 徐丽娜; 卢丽丹

    2012-01-01

    目的 构建弓形虫微线体蛋白( MIC3)的真核表达质粒,为进一步研究MIC3蛋白的功能奠定基础.方法 PCR法扩增弓形虫MIC3目的基因,将纯化的目的基因插入到真核表达质粒PCDNA3.0,并转入DH5α 宿主菌中,在含有青霉素的SOB平板上筛选阳性重组子,采用酶切和PCR扩增法对重组质粒进行鉴定;应用HifectinⅡ真核细胞转染试剂将弓形虫PCDNA-MIC3真核表达质粒转染幼地鼠肾细胞(BHK),表达产物用SDS-PAGE进一步确认,ELISA法检测表达蛋白的免疫原性.结果 重组质粒PCDNA-MIC3经单双酶切及PCR扩增都得到以原插入片段MIC3基因1120 bp大小相同的片段,PCDNA-MIC3能在BHK细胞中高效表达,表达产物能被弓形虫特异性血清所识别.结论 成功构建了弓形虫MIC3基因真核表达质粒PCDNA-MIC3.%Objective To construct eukaryotic expression piasmid of microneme protein MIC3 of Toxoplasma gondii, and so as to lay a foundation for further sturdy on function of protein MIC3. Methods To amplify target gene of Toxoplasma gondii by PCR, insert purified target gene into eukaryotic expression piasmid PCDNA3. 0 and then transfer into host bacteria DH5α, screen positive recombinant on SOB plate that contains penicillin, then carry out identification on the re-combinant plasmid by enzyme digestion and method of PCR amplification, and transfect the constructed eukaryotic expression piasmid of Toxoplasma gondii PCDNA-MIC3 into BHK cells, and further verify the expression product with SDS-PAGE, and test the immunogenicity of expression protein using ELISA, Results For recombinant piasmid PCDNA-MIC3, either by single or double enzyme digestion or PCR amplification, fragment that equals the size of the originally inserted fragment of gene MIC3 1 120 bp were obtained. Toxoplasma gondii PCDNA-MIC3 had high expression in BHK cells, and the expression product could be identified by specific serum of Toxoplasma gondi. Conclusion Eukaryotic expression

  3. Choosing a software design method for real-time Ada applications: JSD process inversion as a means to tailor a design specification to the performance requirements and target machine

    Science.gov (United States)

    Withey, James V.

    1986-01-01

    The validity of real-time software is determined by its ability to execute on a computer within the time constraints of the physical system it is modeling. In many applications the time constraints are so critical that the details of process scheduling are elevated to the requirements analysis phase of the software development cycle. It is not uncommon to find specifications for a real-time cyclic executive program included to assumed in such requirements. It was found that prelininary designs structured around this implementation abscure the data flow of the real world system that is modeled and that it is consequently difficult and costly to maintain, update and reuse the resulting software. A cyclic executive is a software component that schedules and implicitly synchronizes the real-time software through periodic and repetitive subroutine calls. Therefore a design method is sought that allows the deferral of process scheduling to the later stages of design. The appropriate scheduling paradigm must be chosen given the performance constraints, the largest environment and the software's lifecycle. The concept of process inversion is explored with respect to the cyclic executive.

  4. ENVIRONMENTALLY BENIGN MITIGATION OF MICROBIOLOGICALLY INFLUENCED CORROSION (MIC)

    Energy Technology Data Exchange (ETDEWEB)

    John J. Kilbane II; William Bogan

    2004-01-31

    The overall program objective is to develop and evaluate environmentally benign agents or products that are effective in the prevention, inhibition, and mitigation of microbially influenced corrosion (MIC) in the internal surfaces of metallic natural gas pipelines. The goal is to develop one or more environmentally benign (a.k.a. ''green'') products that can be applied to maintain the structure and dependability of the natural gas infrastructure. The technical approach for this quarter included the fractionation of extracts prepared from several varieties of pepper plants, and using several solvents, by high performance liquid chromatography (HPLC). A preliminary determination of antimicrobial activities of the new extracts and fractions using a growth inhibition assay, and evaluation of the extracts ability to inhibit biofilm formation was also performed. The analysis of multiple extracts of pepper plants and fractions of extracts of pepper plants obtained by HPLC illustrated that these extracts and fractions are extremely complex mixtures of chemicals. Gas chromatography-mass spectrometry was used to identify the chemical constituents of these extracts and fractions to the greatest degree possible. Analysis of the chemical composition of various extracts of pepper plants has illustrated the complexity of the chemical mixtures present, and while additional work will be performed to further characterize the extracts to identify bioactive compounds the focus of efforts should now shift to an evaluation of the ability of extracts to inhibit corrosion in mixed culture biofilms, and in pure cultures of bacterial types which are known or believed to be important in corrosion.

  5. Specifications

    International Nuclear Information System (INIS)

    As part of the Danish RERTR Program, three fuel elements with LEU U3O8-Al fuel and three fuel elements with LEU U3Si2-Al fuel were manufactured by NUKEM for irradiation testing in the DR-3 reactor at the Risoe National Laboratory in Denmark. The specifications for the elements with U3O8-Al fuel are presented here as an illustration only. Specifications for the elements with U3Si2-Al fuel were very similar. In this example, materials, material numbers, documents numbers, and drawing numbers specific to a single fabricator have been deleted. (author)

  6. Skilled nursing and rehabilitation facilities - choosing

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/patientinstructions/000436.htm Skilled nursing and rehabilitation facilities - choosing To use the sharing ... you may need to go to a skilled nursing or rehabilitation facility . Skilled nursing facilities provide care ...

  7. Choosing a Geothermal as an HVAC System.

    Science.gov (United States)

    Lensenbigler, John D.

    2002-01-01

    Describes the process of selecting and installing geothermal water source heat pumps for new residence halls at Johnson Bible College in Knoxville, Tennessee, including choosing the type of geothermal design, contractors, and interior equipment, and cost and payback. (EV)

  8. Choosing a Breast Prosthesis: A Survivor's Perspective

    Science.gov (United States)

    ... Survivor’s Perspective Print to PDF Choosing a Breast Prosthesis: A Survivor’s Perspective Andrea Zinn June 16, 2015 · ... did you decide to wear a breast form/prosthesis rather than have a reconstruction? Andrea: After weighing ...

  9. Determination Of Appropriate Antibiotic In Bacterial Meningitis Of Children Based On MIC

    Directory of Open Access Journals (Sweden)

    Noorbakhsh S

    2005-05-01

    Full Text Available Background: Bacterial meningitis is one of the most serious infections in infants and children. Three organisms include S.Pneumo;N.mening;H.Influ are the most common cause of meningitis in children between 2M-14y age.Etest is a new method for determination the MIC of some antimicrobial drugs in agarose .This method is useful for some organisms like as S .Pneumo; N.mening; H.Influ;sensitive Streptococcus and anaerobic ;aerobic gram negative. Materials and Methods: In this descriptive cross sectional study; In 57 suspected meningitis children ; organisms isolated from blood; CSF or other sterile boy fluid after culturing and antibiogram;. .MIC of someorganisms detected by Etest method. Results: Streptococcuswas the most prevalent ( 70% and S.pneumon( 90% of all Streptococcus; H.infl 2%;N.mening 4%and L.monocyt 6%(more than expected;Gram negative (Ecoli; Klebsiella; entrobacter and psudomona 18%. There was significant difference (P =0.01in type of organisms between age groups. S.pneumonia was more frequent in children > 2 year ;N.meningitis in>4yr old .Site of isolation :blood; CSF (35.8*;28.3%other sterile site 18.4%;concomitant positive culture in two site:17%.Mean age in Streptococcus was significantly different with Listeria (p=0.05; N.meningitis (p=0.04;H.influ (p=0.04;.but no difference with Staphylococcus;Klebsiella and E.coli Two type of H.inf were sensitive to Ampici or chloram ;both of them were sensitive to ceftiaxon. GBS were sensitive to PNC or Ampici Strep.nonAnonBnon- Cotrimoxazol>32mic/ml /PNC >256mic/ml/ Vanco>256mic/ml Strep.D: Cotrimoxazol>0.062mg/ml/ /PNC >0.016mic/ml/Imipenem>0.032mic/ml. Strep Pneumonia: All fo them were sensitive except 3 cases /Cotrimoxazol>2ic/ml /PNC =0.01mic/ml/Vanco>0.125mic/ m Vanco>0. 25mic/ ml/.Cotrimoxazol>2ic/ml / PNC =0.01mg/ml Vanco>0.125mic/ ml / Cotrimoxazol>2mic/ml /MIC-PNC >0.016mic/ml Therefore high dose of PNC is adequate for S.pneu ;because of Interm resistance to PNC All 3 N.menin were

  10. ENVIROMENTALLY BENIGN MITIGATION OF MICROBIOLOGICALLY INFLUENCED CORROSION (MIC)

    Energy Technology Data Exchange (ETDEWEB)

    J. Robert Paterek; Gemma Husmillo; Amrutha Daram; Vesna Trbovic

    2003-10-31

    The overall program objective is to develop and evaluate environmentally benign agents or products that are effective in the prevention, inhibition, and mitigation of microbially influenced corrosion (MIC) in the internal surfaces of metallic natural gas pipelines. The goal is to develop one or more environmentally benign (a.k.a. ''green'') products that can be applied to maintain the structure and dependability of the natural gas infrastructure. The technical approach for this quarter includes the application of the method of fractionation of the extracts by high performance liquid chromatography (HPLC); determination of antimicrobial activities of the new extracts and fractions using a growth inhibition assay, and evaluation of the extracts' ability to inhibit biofilm formation. We initiated the delivery system for these new biocides in the test cell and in mixtures of foam components and biocides/anti-biofilms. A total of 51 fractions collected by HPLC from crude extracts that were obtained from three varieties of Capsicum sp. (Serrano, Habanero, Chile de Arbol) were subjected to growth inhibition tests against two SRB strains, D. vulgaris and D. desulfuricans. Five fractions showed growth inhibition against both strains while seven inhibited D. desulfuricans only. The crude extracts did not show growth inhibition on both strains but were proven to be potent in preventing the formation of biofilm. Growth inhibition tests of the same set of crude extracts against Comamonas denitrificans did not show positive results. The fractions will be subjected to biofilm inhibition and dissociation assay as well. The delivery system to be evaluated first was foam. The ''foam pig'' components of surfactants and water were tested with the biocide addition. The first chemical and physical parameters to be tested were pH and surfactants. Tests using the fractionated pepper extracts are progressing rapidly. Gas chromatographic analysis

  11. Determination of pyrazinamide MICs for Mycobacterium tuberculosis at different pHs by the radiometric method.

    OpenAIRE

    Salfinger, M; Heifets, L. B.

    1988-01-01

    The MICs of pyrazinamide (PZA) were determined for Mycobacterium tuberculosis cultivated under different pH conditions in 7H12 liquid medium. Mycobacterial growth was monitored by the radiometric method (BACTEC system; Johnston Laboratories, Inc., Towson, Md.). We observed a predictable eightfold difference between the MICs determined at pH 5.5 and those determined at pH 5.95. The highest MICs for 21 susceptible strains were 50.0 micrograms/ml at pH 5.5 and 400 micrograms/ml at pH 5.95. This ...

  12. Guessing versus Choosing an Upcoming Task.

    Science.gov (United States)

    Kleinsorge, Thomas; Scheil, Juliane

    2016-01-01

    We compared the effects of guessing vs. choosing an upcoming task. In a task-switching paradigm with four tasks, two groups of participants were asked to either guess or choose which task will be presented next under otherwise identical conditions. The upcoming task corresponded to participants' guesses or choices in 75 % of the trials. However, only participants in the Choosing condition were correctly informed about this, whereas participants in the Guessing condition were told that tasks were determined at random. In the Guessing condition, we replicated previous findings of a pronounced reduction of switch costs in case of incorrect guesses. This switch cost reduction was considerably less pronounced with denied choices in the Choosing condition. We suggest that in the Choosing condition, the signaling of prediction errors associated with denied choices is attenuated because a certain proportion of denied choices is consistent with the overall representation of the situation as conveyed by task instructions. In the Guessing condition, in contrast, the mismatch of guessed and actual task is resolved solely on the level of individual trials by strengthening the representation of the actual task. PMID:27047423

  13. TGF-b superfamily cytokine MIC-1/GDF15 is a physiological appetite and body weight regulator.

    Directory of Open Access Journals (Sweden)

    Vicky Wang-Wei Tsai

    Full Text Available The TGF-b superfamily cytokine MIC-1/GDF15 circulates in all humans and when overproduced in cancer leads to anorexia/cachexia, by direct action on brain feeding centres. In these studies we have examined the role of physiologically relevant levels of MIC-1/GDF15 in the regulation of appetite, body weight and basal metabolic rate. MIC-1/GDF15 gene knockout mice (MIC-1(-/- weighed more and had increased adiposity, which was associated with increased spontaneous food intake. Female MIC-1(-/- mice exhibited some additional alterations in reduced basal energy expenditure and physical activity, possibly owing to the associated decrease in total lean mass. Further, infusion of human recombinant MIC-1/GDF15 sufficient to raise serum levels in MIC-1(-/- mice to within the normal human range reduced body weight and food intake. Taken together, our findings suggest that MIC-1/GDF15 is involved in the physiological regulation of appetite and energy storage.

  14. Guidelines for destructive examination of potential MIC [microbiologically influenced corrosion]-related failures

    International Nuclear Information System (INIS)

    Microbiologically influenced corrosion (MIC) is recognized as a major cause of pitting corrosion failures in natural waters. In order to alleviate the problem, it is important to establish the exact cause of corrosion. If there is a possibility that the failure is due to MIC, a particularly careful failure analysis must be conducted. MIC can be misdiagnosed as attack due to conventional chloride crevice/pitting corrosion unless specialized techniques are used. Certain techniques generally must be employed, including a careful visual examination, is situ bacterial sampling of residual water, bacterial analysis for corrosion products, radiographic examinations, and metallographic examinations. Other techniques may be necessary, or may be very helpful in the analysis, including culture growth, scanning electron microscopy, and ultrasonic examinations. Metallographic examinations can reveal MIC characteristics such as selective pitting of one phase in duplex stainless steel weldments. The methods of failure analysis and their importance are addressed, including each of the steps in the nondestructive examinations and destructive analyses

  15. Epidemiological cut-off values for Flavobacterium psychrophilum MIC data generated by a standard test protocol

    DEFF Research Database (Denmark)

    Smith, P.; Endris, R.; Kronvall, G.;

    2016-01-01

    Epidemiological cut-off values were developed for application to antibiotic susceptibility data for Flavobacterium psychrophilum generated by standard CLSI test protocols. The MIC values for ten antibiotic agents against Flavobacterium psychrophilum were determined in two laboratories. For five...

  16. Influence of Water Pollution on MIC of Stainless Steel 304L

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The influence of water pollution and welding defects on MIC (microbiologically influenced corrosion) was studied. The open circuit potential (OCP) was measured during MIC test. It was found that OCP shifted to a higher level when the system was inoculated with bacteria while the OCP of those samples in water without bacteria was kept at a low level. The OCP decreased dramatically when MIC started in polluted water. Combination of weld defect-heat tint, polluted water and adding bacteria causes MIC happen at high rate. Some elements inside the tubercle were analyzed with EDXA. The pits and biofilm were observed with SEM. Microbiological analysis revealed the difference of bacteria between corroded and uncorroded samples.

  17. Correlation of the MIC and dose/MIC ratio of fluconazole to the therapeutic response of patients with mucosal candidiasis and candidemia.

    NARCIS (Netherlands)

    Rodriguez-Tudela, J.L.; Almirante, B.; Rodriguez-Pardo, D.; Laguna, F.; Donnelly, J.P.; Mouton, J.W.; Pahissa, A.; Cuenca-Estrella, M.

    2007-01-01

    We report on the correlation of the outcomes for two cohorts of patients who had been treated for candidemia (126 episodes) or oropharyngeal candidiasis (110 episodes) with various doses of fluconazole and the MIC of fluconazole obtained by using the EUCAST standard for fermentative yeasts. Of 145 e

  18. Susceptibility testing of slowly growing mycobacteria by a microdilution MIC method with 7H9 broth.

    OpenAIRE

    Wallace, R J; Nash, D R; Steele, L C; Steingrube, V

    1986-01-01

    Based on previous success with rapidly growing mycobacteria, a microdilution MIC system was devised for slowly growing mycobacterial species using 7H9 broth. Test drugs included isoniazid, rifampin, ethambutol, streptomycin, clofazamine, and sulfamethoxazole. Sixty isolates of four mycobacterial species, including Mycobacterium tuberculosis, from patients who had never received drug therapy were evaluated in the system, as well as 25 drug-resistant isolates and 11 control strains. MICs were r...

  19. MIC16 gene represents a potential novel genetic marker for population genetic studies of Toxoplasma gondii

    OpenAIRE

    Liu, Wen-Ge; Xu, Xiao-Pei; Chen, Jia; Xu, Qian-Ming; Luo, Si-Long; Zhu, Xing-Quan

    2016-01-01

    Background The zoonotic agent Toxoplasma gondii is distributed world-wide, and can infect a broad range of hosts including humans. Microneme protein 16 of T. gondii (TgMIC16) is responsible for binding to aldolase, and is associated with rhomboid cleavage and presence of trafficking signals during invasion. However, little is known of the TgMIC16 sequence diversity among T. gondii isolates from different hosts and geographical locations. Results In this study, we examined sequence variation i...

  20. In Vitro Selection of Neisseria gonorrhoeae Mutants with Elevated MIC Values and Increased Resistance to Cephalosporins

    OpenAIRE

    Johnson, S. R.; Grad, Yonatan Hagai; Ganakammal, S. R.; Burroughs, M; Frace, M.; Lipsitch, Marc; Weil, R.; Trees, D.

    2014-01-01

    Strains of Neisseria gonorrhoeae with mosaic penA genes bearing novel point mutations in penA have been isolated from ceftriaxone treatment failures. Such isolates exhibit significantly higher MIC values to third-generation cephalosporins. Here we report the in vitro isolation of two mutants with elevated MICs to cephalosporins. The first possesses a point mutation in the transpeptidase region of the mosaic penA gene, and the second contains an insertion mutation in pilQ.

  1. In Vitro selection of Neisseria gonorrhoeae mutants with elevated MIC values and increased resistance to cephalosporins.

    Science.gov (United States)

    Johnson, Steven R; Grad, Yonatan; Ganakammal, Satishkumar Ranganathan; Burroughs, Mark; Frace, Mike; Lipsitch, Marc; Weil, Ryan; Trees, David

    2014-11-01

    Strains of Neisseria gonorrhoeae with mosaic penA genes bearing novel point mutations in penA have been isolated from ceftriaxone treatment failures. Such isolates exhibit significantly higher MIC values to third-generation cephalosporins. Here we report the in vitro isolation of two mutants with elevated MICs to cephalosporins. The first possesses a point mutation in the transpeptidase region of the mosaic penA gene, and the second contains an insertion mutation in pilQ. PMID:25199775

  2. In Vitro selection of Neisseria gonorrhoeae mutants with elevated MIC values and increased resistance to cephalosporins.

    Science.gov (United States)

    Johnson, Steven R; Grad, Yonatan; Ganakammal, Satishkumar Ranganathan; Burroughs, Mark; Frace, Mike; Lipsitch, Marc; Weil, Ryan; Trees, David

    2014-11-01

    Strains of Neisseria gonorrhoeae with mosaic penA genes bearing novel point mutations in penA have been isolated from ceftriaxone treatment failures. Such isolates exhibit significantly higher MIC values to third-generation cephalosporins. Here we report the in vitro isolation of two mutants with elevated MICs to cephalosporins. The first possesses a point mutation in the transpeptidase region of the mosaic penA gene, and the second contains an insertion mutation in pilQ.

  3. Development of biological coal gasification (MicGAS Process). Eighth quarterly report

    Energy Technology Data Exchange (ETDEWEB)

    1992-07-28

    This report describes progress on three fronts of the project. First in studies to elucidate optimal growing conditions for the consortia of coal degraders employed indicates that best growth occurs with 0. 2% w/v Shefton T. Secondly in comparing the biodegradative properties of the coal degraders, isolates identified as Mic-1 and Mic-4 were the best performers. And lastly bioreactors studies in batch mode are related.

  4. Differences in vancomycin MIC among MRSA isolates by agar dilution and E test method

    Directory of Open Access Journals (Sweden)

    K Tandel

    2012-01-01

    Full Text Available In this study, the correlation between vancomycin minimum inhibitory concentration (MIC obtained by the E test technique and the Clinical And Laboratory Standards Institute (CLSI agar dilution method was evaluated. A total of 53 Methicillin Resistant Staphylococcus aureus (MRSA strains were tested by both the methods in the present study. MICs of vancomycin obtained by the E test method were consistently higher (+0.5 to 2 log2 dilutions than those obtained by the agar dilution method. Out of 53 MRSA isolates, 49 isolates showed higher MIC results by E test than by agar dilution method. Three isolates showed same MIC result by both methods. Since many studies have demonstrated increased clinical failure with MRSA isolates for which vancomycin MICs are increased (>1 μg/ml but still within the susceptibility range (≤ 2 μg/ml, our findings suggest the requirement to re-look into the breakpoints for vancomycin for determining sensitivity of MRSA isolates. Guidelines should also specify the method to be used for determining the MIC.

  5. Microbially influenced corrosion (MIC) of metal welds. Kinzoku yosetsubu no biseibutsu fushoku

    Energy Technology Data Exchange (ETDEWEB)

    Kikuchi, Y.; Matsuda, F. (Osaka Univ., Osaka (Japan). Welding Research Inst.)

    1993-06-20

    There is a microbially influenced corrosion (MIC) as one of the relations between the microorganism (bacteria) and the metal engineering. The corrosion accidents, which have been regarded as caused by MIC, have recently occurred in the petrochemical industry, gas industry, energy plant and so forth, and consequently the damage of structures has become to be the circumstances which were not negligible. It has been understood that the welds have a close relation out of the causes. The MIC advances with a very high speed under an existence of the microorganisms when the environmental conditions are satisfied, and even a value of about 0.57 nm/S (18 mm/year) is presumed in an example of SUS304 steel welds. In spite of defects, which were originally caused by the corrosion, there is a possibility that they were judged by mistake as caused by the weld imperfection. The MIC has a close relation with the plural disciplines such as the microbiology, material engineering, corrosion engineering, welding engineering, joining engineering and so forth. In this paper, the cases of MIC in the stainless steel welds, the kind of microorganisms which cause the MIC and the countermeasures agsinst them are outlined. 9 refs., 6 figs.

  6. Evaluation of immune protective efficacies of Eimeria tenella EtMic1 polypeptides with different domain recombination displayed on yeast surface.

    Science.gov (United States)

    Chen, Peipei; Lv, Junfeng; Zhang, Jie; Sun, Hui; Chen, Zhengtao; Li, Hongmei; Wang, Fangkun; Zhao, Xiaomin

    2015-08-01

    In the present study, three different live oral vaccines using the EBY100/pCTCON-2 yeast surface display system with different Eimeria tenella microneme-1 (EtMic1) protein domain recombination were constructed and their protective efficacies against homologous challenge were compared by evaluating the body weight gains, relative growth rate, cecal lesion scores, oocyst output, oocyst decrease ratio, anti-coccidial index, the serum antibody levels and the proliferation ability of blood lymphocytes. The results indicated that all the three constructed live oral vaccines expressing different EtMic1 polypeptides provided excellent protection against homologous challenge by significantly increasing weight gains, reducing cecal lesions, achieving a high ACI, elevating specific antibody response and splenocyte proliferation ability compared with controls. The yeasts displaying the EtMic1 polypeptide-III (expressed TSP-2, TSP-3 and TSP-4 domains) provided better protection against challenge than the yeasts displaying either the EtMic1 polypeptide-I (expressed I-domain, TSP-1 and TSP-2) or polypeptide-II (expressed I-domain and all the five TSP domains) did. Considering the exclusion of antibiotic resistant gene in the system, the strain EBY100 of Saccharomyces cerevisiae may be a better choice for coccidian antigen delivery. PMID:25956946

  7. Antimicrobial Activity of Serbian Propolis Evaluated by Means of MIC, HPTLC, Bioautography and Chemometrics.

    Science.gov (United States)

    Ristivojević, Petar; Dimkić, Ivica; Trifković, Jelena; Berić, Tanja; Vovk, Irena; Milojković-Opsenica, Dušanka; Stanković, Slaviša

    2016-01-01

    New information has come to light about the biological activity of propolis and the quality of natural products which requires a rapid and reliable assessment method such as High Performance Thin-Layer Chromatography (HPTLC) fingerprinting. This study investigates chromatographic and chemometric approaches for determining the antimicrobial activity of propolis of Serbian origin against various bacterial species. A linear multivariate calibration technique, using Partial Least Squares, was used to extract the relevant information from the chromatographic fingerprints, i.e. to indicate peaks which represent phenolic compounds that are potentially responsible for the antimicrobial capacity of the samples. In addition, direct bioautography was performed to localize the antibacterial activity on chromatograms. The biological activity of the propolis samples against various bacterial species was determined by a minimum inhibitory concentration assay, confirming their affiliation with the European poplar type of propolis and revealing the existence of two types (blue and orange) according to botanical origin. The strongest antibacterial activity was exhibited by sample 26 against Staphylococcus aureus, with a MIC value of 0.5 mg/mL, and Listeria monocytogenes, with a MIC as low as 0.1 mg/mL, which was also the lowest effective concentration observed in our study. Generally, the orange type of propolis shows higher antimicrobial activity compared to the blue type. PLS modelling was performed on the HPTLC data set and the resulting models might qualitatively indicate compounds that play an important role in the activity exhibited by the propolis samples. The most relevant peaks influencing the antimicrobial activity of propolis against all bacterial strains were phenolic compounds at RF values of 0.37, 0.40, 0.45, 0.51, 0.60 and 0.70. The knowledge gained through this study could be important for attributing the antimicrobial activity of propolis to specific chemical

  8. Cloud Computing and the Power to Choose

    Science.gov (United States)

    Bristow, Rob; Dodds, Ted; Northam, Richard; Plugge, Leo

    2010-01-01

    Some of the most significant changes in information technology are those that have given the individual user greater power to choose. The first of these changes was the development of the personal computer. The PC liberated the individual user from the limitations of the mainframe and minicomputers and from the rules and regulations of centralized…

  9. Patient values and preferences when choosing anticoagulants

    Directory of Open Access Journals (Sweden)

    Palacio AM

    2015-01-01

    Full Text Available Ana M Palacio,1–3 Irene Kirolos,2,3 Leonardo Tamariz1–3 1The Department of Medicine, Miller School of Medicine, University of Miami, 2The Veterans Affairs Medical Center, Miami, FL, USA; 3Division of Public Health Sciences, University of Miami, Miami, Florida, USA Background: New oral anticoagulants have similar efficacy and lower bleeding rates compared with warfarin. However, in case of bleeding there is no specific antidote to reverse their effects. We evaluated the preferences and values of anticoagulants of patients at risk of atrial fibrillation and those who have already made a decision regarding anticoagulation.Methods: We conducted a cross-sectional study of Veterans in the primary care clinics and the international normalized ratio (INR laboratory. We developed an instrument with patient and physician input to measure patient values and preferences. The survey contained a hypothetical scenario of the risk of atrial fibrillation and the attributes of each anticoagulant. After the scenario, we asked participants to choose the option that best fits their preferences. The options were: 1 has better efficacy at reducing risk of stroke; 2 has been in the market for a long period of time; 3 has an antidote to reverse the rare case of bleeding; 4 has better quality of life profile with no required frequent laboratory tests; or 5 I want to follow physician recommendations. We stratified our results by those patients who are currently exposed to anticoagulants and those who are not exposed but are at risk of atrial fibrillation.Results: We approached 173 Veterans and completed 137 surveys (79% response rate. Ninety subjects were not exposed to anticoagulants, 46 reported being on warfarin, and one reported being on dabigatran at the time of the survey. Ninety-eight percent of subjects stated they would like to participate in the decision-making process of selecting an anticoagulant. Thirty-six percent of those exposed and 37% of those

  10. Why Do Individuals Choose Self-Employment?

    OpenAIRE

    Dawson, Christopher; Henley, Andrew; Latreille, Paul L.

    2009-01-01

    This paper undertakes an analysis of the motivating factors cited by the self-employed in the UK as reasons for choosing self-employment. Very limited previous research has addressed the question of why individuals report that they have chosen self-employment. Two questions are addressed using large scale labour force survey data for the UK. The first concerns the extent to which the self-employed are self-employed out of necessity, opportunity, lifestyle decision or occupational choice. The ...

  11. Choosing experiments to accelerate collective discovery

    OpenAIRE

    Rzhetsky, Andrey; Foster, Jacob G.; Foster, Ian T.; Evans, James A.

    2015-01-01

    Scientists perform a tiny subset of all possible experiments. What characterizes the experiments they choose? And what are the consequences of those choices for the pace of scientific discovery? We model scientific knowledge as a network and science as a sequence of experiments designed to gradually uncover it. By analyzing millions of biomedical articles published over 30 y, we find that biomedical scientists pursue conservative research strategies exploring the local neighborhood of central...

  12. ALGORITHM OF CHOOSING ASPHALT MIXING PLANTS

    OpenAIRE

    Zhukov, P.; Kravchuk, Y.; Zhukov, D.

    2010-01-01

    The development of transport infrastructure, which must conform to European standards and in its turn requires the development of road economy, is one of the ways out of the crisis. The development of road economy requires either construction of asphalt-concrete mixture plants or their modernization, or reconstruction of existing plants. Any reconstruction or modernization and, moreover, construction of new asphalt-concrete plants requires the optimization of choosing the most efficient aspha...

  13. A Randomized Procedure for Choosing Data Transformation

    OpenAIRE

    Valentina Corradi; Swanson, Norman R.

    2001-01-01

    Standard unit root and stationarity tests (see e.g. Dickey and Fuller (1979)) assume linearity under both the null and the alternative hypothesis. Violation of this linearity assumption can result in severe size and power distortion, both in finite and large samples. Thus, it is reasonable to address the problem of data transformation before running a unit root test. In this paper we propose a simple randomized procedure, coupled with sample conditioning, for choosing between levels and log-l...

  14. Initial Results from the CRRES/MICS Empirical Model of Ion Plasma in the Inner Magnetosphere

    Science.gov (United States)

    Claudepierre, Seth; Roeder, James; Chen, Margaret; Lemon, Colby; Guild, Timothy

    2013-04-01

    We present initial results from a recently developed empirical model of low energy ion plasma (~1-300 keV/e) in the inner magnetosphere. This model is constructed from data taken by the Magnetospheric Ion Composition Spectrometer (MICS) on-board the Combined Release and Radiation Effects Satellite (CRRES). The model has been constructed in a similar fashion to the Roeder et al., [2005] CAMMICE/MICS model, which used NASA Polar satellite data. The orbital differences between CRRES (GTO) and Polar (highly-inclined polar orbit) result in each spacecraft sampling different portions of the ion pitch-angle distributions. Such models can be used to estimate the average flux for major ion species (e.g. H+, He+, He++, O+) along any orbit in the inner magnetosphere. To construct this new model, CRRES/MICS ion fluxes were computed and sorted into bins of magnetic coordinates L, MLT, MLAT, equatorial pitch-angle and activity indices. Preliminary comparisons are made between the CAMMICE/MICS and CRRES/MICS models, highlighting the strengths and limitations of both. We also consider the average O+ ion flux deduced from the model in various spatial and activity ranges and qualitatively compare with what is to be expected from O+ ion transport and loss processes.

  15. Eimeria tenella microneme protein EtMIC3: identification, localisation and role in host cell infection.

    Science.gov (United States)

    Labbé, M; de Venevelles, P; Girard-Misguich, F; Bourdieu, C; Guillaume, A; Péry, P

    2005-03-01

    The gene coding for Eimeria tenella protein EtMIC3 was cloned by screening a sporozoite cDNA library with two independent monoclonal antibodies raised against the oocyst stage. The deduced sequence of EtMIC3 is 988 amino acids long. The protein presents seven repeats in tandem, with four highly conserved internal repeats and three more divergent external repeats. Each repeat is characterised by a tyrosine kinase phosphorylation site, WRCY, and a reminiscent motif of the thrombospondin1 (TSP1)-type I domain, CXXXCG. The protein EtMIC3 is localised at the apex of free parasite stages. It is not detected in the early intracellular parasite stage but is synthesised in mature schizonts. Secretion of the protein is induced when sporozoites are incubated in complete medium at 41 degrees C. Strangely enough, the two independent mAb that allow cloning of EtMIC3 interfere with parasitic growth in different ways. One is able to inhibit parasite invasion whereas the other inhibits development. Expression and localisation of the protein EtMIC3 are consistent with a protein involved in the invasion process as is expected for a microneme protein.

  16. El cómic en España: 1977-2007

    Directory of Open Access Journals (Sweden)

    Pablo Vergara Díaz

    2009-07-01

    Full Text Available Este artículo pretende repasar las tres últimas décadas del cómic en España. El estudio se realiza valorando la evolución de la industria del cómic, desde sus inicios durante la dictadura y su expansión con la llegada de la democracia hasta la época actual de dificultades y cambios. El auge del cómic se observa en su relevancia creciente dentro de la prensa, en la aceptación de un público que va madurando con el paso del tiempo y, sobre todo, en las ventas de una industria que tiene que adaptarse a nuevas situaciones.

  17. En el umbral. El cómic español contemporáneo

    Directory of Open Access Journals (Sweden)

    García, Santiago

    2011-09-01

    Full Text Available These days, when we talk about contemporary Spanish comics, or comics produced primarily in Spain for the Spanish market, we have to contemplate two main trends: the graphic novel and the humor comics. The fall of the traditional industry opened the door to the realization of authoral ambitions that previous generations of artists couldn’t fulfil.

    En la actualidad, cuando hablamos de cómic español contemporáneo, es decir, cuando nos referimos a cómics producidos en España y para el mercado español en primer lugar, tenemos que tener en cuenta dos corrientes principalmente: la novela gráfica y el cómic de humor. La caída de la industria tradicional ha abierto el camino para que se cumplan las aspiraciones autorales que durante décadas tuvieron muchos dibujantes españoles.

  18. Dynamic Ni gettered by PSG from S-MIC poly-Si and its TFTs

    Institute of Scientific and Technical Information of China (English)

    Meng Zhi-Guo; Li Yang; Wu Chun-Ya; Zhao Shu-Yun; Li Juan; Man Wong; Hoi Sing-Kwok; Xiong Shao-Zhen

    2008-01-01

    A dynamic phosphor-silicate glass (PSG) gettering method is proposed in which the processes of the gettering of Ni by PSG and the crystallizing of á-Si into poly-Si by Ni take place simultaneously. The effects of PSG gettering process on the performances of solution-based metal induced crystallized (S-MIC) poly-Si materials and their thin film transistors (TFTs) are discussed. The crystallization rate is much reduced due to the fact that the Ni as a medium source of crystallization is extracted by the PSG during crystallization at the same time. The boundary between two neighbouriug grains in S-MIC poly-Si with PSG looks blurrier than without PSG. Compared with the TFTs made from S-MIC poly-Si without PSG gettering, the TFTs made with PSG gettering has a reduced gate induced leakage current.

  19. Poisson mechanics for perturbed MIC-Kepler problems at both positive and negative energies

    Science.gov (United States)

    Iwai, Toshihiro; Matsumoto, Shogo

    2012-09-01

    The MIC-Kepler problem, an extension of the Kepler problem, is known to admit the symmetry group SU(2) × SU(2) or SL(2, {C}), according to whether the energy is negative or positive. In general, each of the co-adjoint orbits of a Lie group carries the canonical symplectic form called the KKS form, and a Hamiltonian dynamical system is defined on it if a suitable Hamiltonian is given. Perturbed MIC-Kepler problems can be treated in this setting if a perturbed Hamiltonian in normal form is determined according to whether the energy is negative or positive. Since the co-adjoint orbit in question can be viewed as a symplectic leaf of the associated Lie algebra \\mathfrak {su}(2)\\oplus \\mathfrak {su}(2) or \\mathfrak {sl}(2, {C}) according to whether the energy is negative or positive, the perturbed MIC-Kepler problems in normal form can be described in the Poisson mechanics defined on respective symmetry Lie algebras. Thus, the equations of motion for perturbed systems can be described in the form of Poisson brackets for both cases of \\mathfrak {su}(2)\\oplus \\mathfrak {su}(2) and \\mathfrak {sl}(2, {C}) on an equal footing. It will be shown further how two parameters assigning a co-adjoint orbit of SU(2) × SU(2) or SL(2, {C}) are related to the parameters contained in the MIC-Kepler problem. The perturbation of the MIC-Kepler problem to be treated in this article is rather restricted to that caused by the presence of weak constant electric and magnetic fields orthogonal to each other. When regularized, the perturbed Hamiltonians at both positive and negative energies are put in the Birkhoff-Gustavson normal form and thereby the flows generated by the perturbed Hamiltonians are studied in Poisson mechanics in terms of variables associated with constants of motion for the MIC-Kepler problem.

  20. The "Binarity and Magnetic Interactions in various classes of Stars" (BinaMIcS) project

    OpenAIRE

    Neiner, C.; Morin, J.; Alecian, E.; collaboration, the BinaMIcS

    2015-01-01

    The "Binarity and Magnetic Interactions in various classes of stars" (BinaMIcS) project is based on two large programs of spectropolarimetric observations with ESPaDOnS at CFHT and Narval at TBL. Three samples of spectroscopic binaries with two spectra (SB2) are observed: known cool magnetic binaries, the few known hot magnetic binaries, and a survey sample of hot binaries to search for additional hot magnetic binaries. The goal of BinaMIcS is to understand the complex interplay between stell...

  1. Anti-MIC2 as a tool in examination of testicular biopsies

    DEFF Research Database (Denmark)

    Visfeldt, J; Cortes, D; Thorup, J M;

    1999-01-01

    is recommended in order to evaluate future fertility potential. The spermatogonia are identified on histological sections and the number per tubular transverse section is compared with normal values for age. The patient is at 33-100% risk of subsequent infertility when the number of spermatogonia per...... palpable testes which had been cultured in vitro for 7, 14 or 21 days. In all cases the immunohistochemical method with DAKO antibody to the MIC2 gene product was helpful for identification of Sertoli cells and germ cells, and we therefore recommend the use of anti-MIC2 in all testicular biopsies where it...

  2. Coneixements previs i rendiment acadèmic a la Universitat

    OpenAIRE

    García Gay, Lourdes

    1999-01-01

    CONEIXEMENTS PREVIS I RENDIMENT ACADÈMIC A LA UNIVERSITATAdoptant el model del constructivisme, la tesi es proposa com a objectiu esbrinar quina és la base acadèmica de l'alumnat en arribar als estudis universitaris de Fisioteràpia i comprovar si aquesta base influeix en el rendiment acadèmic durant el primer curs de la carrera.La tesi està estructurada en dues parts. En la fonamentació teòrica cal considerar el context en què se situa la tesi (canvi del sistema educatiu, renovació de les PAA...

  3. Performance of a 100V Half-Bridge MOSFET Driver, Type MIC4103, Over a Wide Temperature Range

    Science.gov (United States)

    Patterson, Richard L.; Hammoud, Ahmad

    2011-01-01

    The operation of a high frequency, high voltage MOSFET (metal-oxide semiconductor field-effect transistors) driver was investigated over a wide temperature regime that extended beyond its specified range. The Micrel MIC4103 is a 100V, non-inverting, dual driver that is designed to independently drive both high-side and low-side N-channel MOSFETs. It features fast propagation delay times and can drive 1000 pF load with 10ns rise times and 6 ns fall times [1]. The device consumes very little power, has supply under-voltage protection, and is rated for a -40 C to +125 C junction temperature range. The floating high-side driver of the chip can sustain boost voltages up to 100 V. Table I shows some of the device manufacturer s specification.

  4. MILLIMETER EMISSION STRUCTURE IN THE FIRST ALMA IMAGE OF THE AU Mic DEBRIS DISK

    NARCIS (Netherlands)

    MacGregor, Meredith A.; Wilner, David J.; Rosenfeld, Katherine A.; Andrews, Sean M.; Matthews, Brenda; Hughes, A. Meredith; Booth, Mark; Chiang, Eugene; Graham, James R.; Kalas, Paul; Kennedy, Grant; Sibthorpe, Bruce

    2013-01-01

    We present 1.3 mm ALMA Cycle 0 observations of the edge-on debris disk around the nearby, similar to 10 Myr old, M-type star AU Mic. These observations obtain 0 ''.6 (6 AU) resolution and reveal two distinct emission components: (1) the previously known dust belt that extends to a radius of 40 AU an

  5. EIS study of MIC in three different zones derived from ship ballast tank model system

    NARCIS (Netherlands)

    Heyer, A.; Mol, J.M.C.; D'Souza, F.; Wit, J.H.W. de; Ferrari, G.

    2011-01-01

    Microbiologically influenced corrosion (MIC) is a well known phenomenon in aquatic environments [1]. The presence of a biofilm on metal surface often establishes new electrochemical reaction pathways, or promotes reactions which are not normally favored in the absence of microorganisms, resulting in

  6. Sin City: cuando el cine se rinde a los pies del cómic

    OpenAIRE

    Echazarreta Soler, Carmen

    2006-01-01

    Proposta didàctica que se situa entre els llenguatges del còmic i del cinema per a promoure la reflexió sobre la cerca de noves formes de narrar. El fil conductor és Sin City i es proposen, també, 10 activitats per als alumnes

  7. Correlation of MIC value and disk inhibition zone diameters in clinical Legionella pneumophila serogroup 1 isolates

    NARCIS (Netherlands)

    Bruin, J.P. de; Diederen, B.M.; Ijzerman, E.P.; Boer, J.W. den; Mouton, J.W.

    2013-01-01

    OBJECTIVES: Routine use of disk diffusion tests for detecting antibiotic resistance in Legionella pneumophila has not been described. The goal of this study was to determine the correlation of MIC values and inhibition zone diameter (MDcorr) in clinical L. pneumophila isolates. METHODS: Inhibition z

  8. Molecular Evolution of Clustered MIC-3 (Meloidogyne Induced Cotton -3) Multigene Family of Gossypium Species

    Science.gov (United States)

    Uniqueness, content, localization, and defense-related features of the root-knot nematode resistance-associated MIC-3 multigene cluster in the genus Gossypium are all of interest for molecular evolutionary studies of duplicate genes in allopolyploids. Here we report molecular evolutionary rates of t...

  9. MICs of Oxazolidinones for Rhodococcus equi Strains Isolated from Humans and Animals

    OpenAIRE

    Bowersock, Terry L.; Salmon, Sarah A.; Portis, Ellen S.; Prescott, John F.; Robison, Denise A.; Ford, Charles W.; Watts, Jeffrey L.

    2000-01-01

    Eperezolid and linezolid are representatives of a new class of orally active, synthetic antimicrobial agents. The in vitro activity values (MICs) of linezolid, eperezolid, and comparator antibiotics against 102 strains of Rhodococcus equi isolated from humans and animals were determined. Linezolid was more active than eperezolid against the strains tested; premafloxacin was the most active comparator antibiotic.

  10. Algebraic Treatment of the MIC-Kepler System in Spherical Coordinates

    Institute of Scientific and Technical Information of China (English)

    M. T. Chefrour

    2007-01-01

    @@ The MIC-Kepler system is studied via the Milshtein-Strakhovenko variant of the so(2,1) Lie algebra. Green's function is constructed in spherical coordinates, with the help of the Kustaanheimo-Stiefel variables and the generators of the SO(2,1) group. The energy spectrum and the normalized wavefunctions of the bound states are obtained.

  11. Study of MIC impact in a full-scale ship ballast tank

    NARCIS (Netherlands)

    Heyer, A.; Mol, J.M.C.; D'Souza, F.; Wit, J.H.W. de; Ferrari, G.

    2012-01-01

    Microbiologically influenced corrosion (MIC) of steel is a serious problem in the marine environment and many industries, such as the shipping industry. While electrochemical measurements such as impedance have been used in corrosion monitoring for several years, the true capabilities of the techniq

  12. The Identity of Students Choosing Marketing Programs

    Directory of Open Access Journals (Sweden)

    Barreto, Idaly

    2009-12-01

    Full Text Available The purpose of this study is to look deeply into the identity of young students interested in training professional in marketing programs in Bogotá, Colombia. This descriptive study was conducted with the application of multidimensional surveys to 262 young people from five universities that offer training in marketing. The results show that there are differences and similarities in the lifestyles of young people who choose to study Marketing. The first, relating mainly to the identities assumed by students of daytime and nighttime that differ in their activities and more income. The second, by the increasing use and development of academic and social activities through the Internet of interest to young people today. It is hoped that these results provide the administrative and academic management of marketing programs that result in better communication and care of students as consumers.

  13. A thermodynamic approach to choosing pervaporatives membranes

    Directory of Open Access Journals (Sweden)

    Mahacine Amrani

    2010-04-01

    Full Text Available This work describes separating a mixture of several components obtained as a product of methyl polymethyl metha- crylate (PMMA thermo-degradation. It was aimed at purifying methyl methacrylate monomer (MMA obtained by 95% mass thermal degradation to reach 99.5% maximum pervaporation concentration. This work studied the theory of pervaporation and applying the main thermodynamic criteria for choosing suitable polymer membranes for separating the MMA/PRP/ISB mixture. Such thermodynamic criteria were based on monomer interaction with and solubility on the membrane. The advantage of using this separation technique lies mainly in the fact that this method has low energy consumption compared to other processes, such as distillation or crystallisation.

  14. How to choose the right financial planner.

    Science.gov (United States)

    Maurer, Timothy J

    2010-01-01

    An "economic Pearl Harbor." That is how the world's most famous investor, Warren Buffett, described what we have gone through and what we're still going through.' Even the most optimistic appraisals of our economic conditions suggest that we are likely to feel the effects of the Great Recession through the decade we recently entered. Healthcare reform, in whatever form, may also create change in your medical practice ranging from immaterial to revolutionary. To whom should you turn to ensure that your personal economy survives and thrives, especially in these times? A financial planner, possibly, but what is a financial planner, how do you choose one, and what sort of service should you expect? PMID:20839512

  15. Why do men choose to become pedagogues?

    DEFF Research Database (Denmark)

    Wohlgemuth, Ulla Gerner

    2015-01-01

    This article reports the results from a study on reasons for choosing social education for a profession when you are a man. The study concluded that multiple job opportunities and caring for others is a strong motive for men along with possible further studies. The study also disclosed that many...... men still encounter incomprehension when stating their choice of career. The study is actualised by five new projects supported by the Ministry of Children, Gender Equality, Integration and Social Affairs (MBLIS). These five projects are engaged to seek new ways within attraction and recruitment...... of (more) men to early childhood education (ECE). By now the projects have completed interesting practices when aiming to attract and recruit men and the pedagogues engaged in the projects have gained new perspectives on their profession. However, attracting men to study programmes within care and ECE...

  16. How to choose the right financial planner.

    Science.gov (United States)

    Maurer, Timothy J

    2010-01-01

    An "economic Pearl Harbor." That is how the world's most famous investor, Warren Buffett, described what we have gone through and what we're still going through.' Even the most optimistic appraisals of our economic conditions suggest that we are likely to feel the effects of the Great Recession through the decade we recently entered. Healthcare reform, in whatever form, may also create change in your medical practice ranging from immaterial to revolutionary. To whom should you turn to ensure that your personal economy survives and thrives, especially in these times? A financial planner, possibly, but what is a financial planner, how do you choose one, and what sort of service should you expect?

  17. Differential association of fluconazole dose and dose/MIC ratio with mortality in patients with Candida albicans and non-albicans bloodstream infection.

    Science.gov (United States)

    Brosh-Nissimov, T; Ben-Ami, R

    2015-11-01

    Targeting fluconazole therapy to achieve predefined pharmacodynamic goals has been suggested as a means of optimizing the treatment of patients with candidaemia. However, data regarding species-specific dosing targets are inconclusive. We retrospectively analysed a cohort of 75 adult patients with Candida bloodstream infection (BSI) who received initial treatment with fluconazole for ≥48 h (36 Candida albicans and 39 non-albicans Candida (NAC)). Fluconazole dose, the dose/MIC ratio and the 24-h area under the concentration-time curve (AUC24)/MIC ratio were determined for each patient, and classification and regression tree analysis was used to determine breakpoints for significant interactions with 30-day survival. Both fluconazole exposure parameters and patient-related and disease-related variables were assessed in univariable and multivariable survival models. The crude 30-day mortality rate was 32% (44% and 21% for C. albicans and NAC, respectively). An average fluconazole dose of >200 mg/day, a dose/MIC ratio of >400 and an AUC24/MIC ratio of >400 were associated with a higher 30-day survival rate and better microbiological response in patients with C. albicans BSI but not in those with NAC BSI. Baseline chronic kidney disease was a risk factor for fluconazole underdosing and mortality. Severity of sepsis (Sequential Organ Failure Assessment score) was the only significant predictor of death in patients with NAC BSI. We conclude that, although pharmacodynamic target-directed fluconazole dosing may help to optimize outcomes for patients with C. albicans BSI, additional studies are needed to define the role of fluconazole in the treatment of NAC BSI.

  18. Differential association of fluconazole dose and dose/MIC ratio with mortality in patients with Candida albicans and non-albicans bloodstream infection.

    Science.gov (United States)

    Brosh-Nissimov, T; Ben-Ami, R

    2015-11-01

    Targeting fluconazole therapy to achieve predefined pharmacodynamic goals has been suggested as a means of optimizing the treatment of patients with candidaemia. However, data regarding species-specific dosing targets are inconclusive. We retrospectively analysed a cohort of 75 adult patients with Candida bloodstream infection (BSI) who received initial treatment with fluconazole for ≥48 h (36 Candida albicans and 39 non-albicans Candida (NAC)). Fluconazole dose, the dose/MIC ratio and the 24-h area under the concentration-time curve (AUC24)/MIC ratio were determined for each patient, and classification and regression tree analysis was used to determine breakpoints for significant interactions with 30-day survival. Both fluconazole exposure parameters and patient-related and disease-related variables were assessed in univariable and multivariable survival models. The crude 30-day mortality rate was 32% (44% and 21% for C. albicans and NAC, respectively). An average fluconazole dose of >200 mg/day, a dose/MIC ratio of >400 and an AUC24/MIC ratio of >400 were associated with a higher 30-day survival rate and better microbiological response in patients with C. albicans BSI but not in those with NAC BSI. Baseline chronic kidney disease was a risk factor for fluconazole underdosing and mortality. Severity of sepsis (Sequential Organ Failure Assessment score) was the only significant predictor of death in patients with NAC BSI. We conclude that, although pharmacodynamic target-directed fluconazole dosing may help to optimize outcomes for patients with C. albicans BSI, additional studies are needed to define the role of fluconazole in the treatment of NAC BSI. PMID:26183300

  19. Macrophage inhibitory cytokine-1 (MIC-1/GDF15 gene deletion promotes cancer growth in TRAMP prostate cancer prone mice.

    Directory of Open Access Journals (Sweden)

    Yasmin Husaini

    Full Text Available The divergent TGF-β superfamily member, macrophage inhibitory cytokine-1 (MIC-1/GDF15, is overexpressed by most cancers, including prostate cancer (PCa. Whilst its circulating levels are linked to cancer outcome, the role MIC-1/GDF15 plays in cancer development and progression is incompletely understood. To investigate its effect on PCa development and spread, we have used TRAMP prostate cancer prone mice bearing a germline deletion of MIC-1/GDF15 (TRAMPMIC-/-. On average TRAMPMIC-/- mice died about 5 weeks earlier and had larger prostatic tumors compared with TRAMP mice that were wild type for MIC-1/GDF15 (TRAMPMIC+/+. Additionally, at the time of death or ethical end point, even when adjusted for lifespan, there were no significant differences in the number of mice with metastases between the TRAMPMIC+/+ and TRAMPMIC-/- groups. However, consistent with our previous data, more than twice as many TRAMP mice overexpressing MIC-1/GDF15 (TRAMPfmsmic-1 had metastases than TRAMPMIC+/+ mice (p<0.0001. We conclude that germ line gene deletion of MIC-1/GDF15 leads to increased local tumor growth resulting in decreased survival consistent with an overall protective role for MIC-1/GDF15 in early primary tumor development. However, in advancing disease, as we have previously noted, MIC-1/GDF15 overexpression may promote local invasion and metastatic spread.

  20. Discrepancy in Vancomycin AUC/MIC Ratio Targeted Attainment Based upon the Susceptibility Testing in Staphylococcus aureus

    Directory of Open Access Journals (Sweden)

    Seenae Eum

    2016-09-01

    Full Text Available This study demonstrated a statistically significant difference in vancomycin minimum inhibitory concentration (MIC for Staphylococcus aureus between a common automated system (Vitek 2 and the E-test method in patients with S. aureus bloodstream infections. At an area under the serum concentration time curve (AUC threshold of 400 mg∙h/L, we would have reached the current Infectious Diseases Society of America (IDSA/American Society of Health System Pharmacists (ASHP/Society of Infectious Diseases Pharmacists (SIDP guideline suggested AUC/MIC target in almost 100% of patients while using the Vitek 2 MIC data; however, we could only generate 40% target attainment while using E-test MIC data (p < 0.0001. An AUC of 450 mg∙h/L or greater was required to achieve 100% target attainment using either Vitek 2 or E-test MIC results.

  1. Choosing change strategy for ISO/IEC 33014

    DEFF Research Database (Denmark)

    Pries-Heje, Jan; Johansen, Jørn

    2015-01-01

    of how to select change strategy. The framework contains 10 different change strategies to choose from. But which ones are chosen in practice? To answer that, we have analyzed data from 134 assessments in 129 organizations that have used the framework. We give a ranking of strategies chosen, and we......The ISO/IEC 33014.2013 [1] standard on process improvement includes a core activity called ‘identify the overall change strategy’, which includes selecting a change strategy among the many available. This selection can be carried out using the ImprovAbility model [2] in which there is a framework...... analyze how they adapt the change strategy to their specific conditions. We conclude that the most often recommended organizational change strategy is optionality followed by three other strategies: specialist-driven, production-organized, and learning-driven....

  2. Vancomycin, teicoplanin, daptomycin, and linezolid MIC creep in methicillin-resistant Staphylococcus aureus is associated with clonality

    Science.gov (United States)

    Hsieh, Yu-Chia; Lin, Yu-Chun; Huang, Yhu-Chering

    2016-01-01

    Abstract The purpose of this study is to evaluate the susceptibility trend of vancomycin, teicoplanin, daptomycin, and linezolid against methicillin-resistant Staphylococcus aureus (MRSA) blood isolates of different clones over an 11-year period. From 2000 to 2010, all bloodstream MRSA isolates from Chang Gung Memorial Hospital in Taiwan were prospectively collected. Three periods, namely 2000 to 2001, 2004 to 2005, and 2010, were included and 124 MRSA isolates were selected from each period. Minimum inhibitory concentrations (MICs) were determined by E-test. All the isolates were molecularly characterized. MRSA molecular epidemiology evolved from 1 predominant pulsotype (type A) to 5 major pulsotypes of 3 clonal complexes (CC). Vancomycin, teicoplanin, and daptomycin MICs creep were observed, particularly for pulsotype A-CC 239-staphylococcal cassette chromosome mec (SCCmec) III though its prevalence dramatically decreased since 2004 to 2005. Throughout the study period, the overall vancomycin modal MIC was stable at 1.5 mg/L, but teicoplanin and linezolid modal MIC increased to 2 and 2 mg/L, respectively. Isolates with teicoplanin and linezolid ≧ 2 ug/mL belonged to multiple clones. Pulsotype F-ST5-SCCmec II with a high rate of teicoplanin MIC ≧ 2 ug/mL continued clonal spread. Teicoplanin MIC had a high correlation with linezolid MIC. Molecular epidemiology MRSA bloodstream isolates in northern Taiwan evolved from 2000 throughout 2010, which was subsequently associated with the changing distribution of antibiotic MICs. While vancomycin MIC level remained unchanged, teicoplanin, daptomycin, and linezolid MIC levels increased. The impact of these changes on clinical treatment response deserves further investigations. PMID:27741120

  3. Choosing the best heuristic for seeded alignment of DNA sequences

    Directory of Open Access Journals (Sweden)

    Buhler Jeremy

    2006-03-01

    Full Text Available Abstract Background Seeded alignment is an important component of algorithms for fast, large-scale DNA similarity search. A good seed matching heuristic can reduce the execution time of genomic-scale sequence comparison without degrading sensitivity. Recently, many types of seed have been proposed to improve on the performance of traditional contiguous seeds as used in, e.g., NCBI BLASTN. Choosing among these seed types, particularly those that use information besides the presence or absence of matching residue pairs, requires practical guidance based on a rigorous comparison, including assessment of sensitivity, specificity, and computational efficiency. This work performs such a comparison, focusing on alignments in DNA outside widely studied coding regions. Results We compare seeds of several types, including those allowing transition mutations rather than matches at fixed positions, those allowing transitions at arbitrary positions ("BLASTZ" seeds, and those using a more general scoring matrix. For each seed type, we use an extended version of our Mandala seed design software to choose seeds with optimized sensitivity for various levels of specificity. Our results show that, on a test set biased toward alignments of noncoding DNA, transition information significantly improves seed performance, while finer distinctions between different types of mismatches do not. BLASTZ seeds perform especially well. These results depend on properties of our test set that are not shared by EST-based test sets with a strong bias toward coding DNA. Conclusion Practical seed design requires careful attention to the properties of the alignments being sought. For noncoding DNA sequences, seeds that use transition information, especially BLASTZ-style seeds, are particularly useful. The Mandala seed design software can be found at http://www.cse.wustl.edu/~yanni/mandala/.

  4. Motivations for choosing various food groups based on individual foods.

    Science.gov (United States)

    Phan, Uyen T X; Chambers, Edgar

    2016-10-01

    Understanding "why people eat what they eat" is important for improving the lives of people around the world by helping provide industrial and social solutions for people to have greater pleasure and health from the foods they choose. The objective of this study was to investigate the motivations behind everyday choices of different food groups using a bottom-up approach that targeted the specific choices of foods and beverages people consumed at various times of a day. This study was conducted using an online survey included questions related to demographics, the most recent meal including specific food choices, and a slightly modified Eating Motivation Surveys (2 motivations were added, and Check-All-That-Apply procedure was used), which contained 50 sub-scales to measure 17 motivations including such topics as Liking, Pleasure, Convenience, Health, Price, Variety Seeking etc. A total of 198 participants have completed the surveys. Data were analyzed by Correspondence Analysis. Liking was found to be the strongest motivation that drove people to select all sorts of foods. Need and Hunger and Convenience were the main motivations for baked products, "fast" foods, sausages and meats, and snack foods while Health and Weight Control were found to be the main driving factors for vegetables, fruits & fruit juices, nuts, seeds, dairy & egg, and poultry products. Sweets were linked to Pleasure. For beverages, people were motivated most by Heath and Weight Control to choose water and tea. Coffee was used due to Habits; soda was because of Pleasure and alcoholic was for socialization purposes. This study provided developers, marketers, health educators, etc. With a new method to understand food choice in order to promote better eating. PMID:27235822

  5. The "Binarity and Magnetic Interactions in various classes of stars" (BinaMIcS) project

    Science.gov (United States)

    Neiner, C.; Morin, J.; Alecian, E.

    2015-12-01

    The "Binarity and Magnetic Interactions in various classes of stars" (BinaMIcS) project is based on two large programs of spectropolarimetric observations with ESPaDOnS at CFHT and Narval at TBL. Three samples of spectroscopic binaries with two spectra (SB2) are observed: known cool magnetic binaries, the few known hot magnetic binaries, and a survey sample of hot binaries to search for additional hot magnetic binaries. The goal of BinaMIcS is to understand the complex interplay between stellar magnetism and binarity. To this aim, we will characterise and model the magnetic fields, magnetospheric structure and coupling of both components of hot and cool close binary systems over a significant range of evolutionary stages, to confront current theories and trigger new ones. First results already provided interesting clues, e.g. about the origin of magnetism in hot stars.

  6. The "Binarity and Magnetic Interactions in various classes of Stars" (BinaMIcS) project

    CERN Document Server

    Neiner, C; Alecian, E

    2015-01-01

    The "Binarity and Magnetic Interactions in various classes of stars" (BinaMIcS) project is based on two large programs of spectropolarimetric observations with ESPaDOnS at CFHT and Narval at TBL. Three samples of spectroscopic binaries with two spectra (SB2) are observed: known cool magnetic binaries, the few known hot magnetic binaries, and a survey sample of hot binaries to search for additional hot magnetic binaries. The goal of BinaMIcS is to understand the complex interplay between stellar magnetism and binarity. To this aim, we will characterise and model the magnetic fields, magnetospheric structure and coupling of both components of hot and cool close binary systems over a significant range of evolutionary stages, to confront current theories and trigger new ones. First results already provided interesting clues, e.g. about the origin of magnetism in hot stars.

  7. Localizing Plages on BO Mic, First steps towards chromospheric Doppler imaging

    CERN Document Server

    Wolter, U

    2005-01-01

    We have obtained a densely sampled time series of CaII H&K line profiles of the ultrafast rotating K-dwarf star BO Mic. Taken at high resolution, the spectra reveal pronounced variations of the emission core profiles. We interpret these variations as signs of concentrated chromospherically active regions, in analogy to solar plages. We further interpret the variations as partly due to the rapid growth and decay of plages, while other variations appear to be caused by plages moved over the visible stellar disk by rotation. The equivalent width of the Ca K core emission changes approximately in anti-phase to the photospheric brightness, suggesting an association of the chromospheric plage regions with pronounced dark photospheric spots. We believe that further analysis of the presented spectral time series will lead to a chromospheric Doppler image of BO mic.

  8. Correlation between beta-lactamase production and MIC values against penicillin with coagulase negative staphylococci.

    Directory of Open Access Journals (Sweden)

    Narayani T

    1989-07-01

    Full Text Available Two hundred strains of coagulase negative staphylococci (CNS isolated from various clinical specimens (116 and healthy hospital personnel (84 were investigated for the production of beta-lactamases by means of three iodometric techniques and correlated with the minimum inhibitory concentration (MIC values of penicillin-G by agar dilution technique and disc diffusion technique. One hundred and fifty (75.0% of the 200 strains tested produced beta-lactamases. Seventy two per cent of the CNS were found to be beta-lactamase positive by the starch paper technique which was the most sensitive one in our study. The MIC values of penicillin against CNS ranged from less than or equal to 1.25 to greater than or equal to 2000 units. The present study indicated the higher prevalence of beta-lactamase producers with increased penicillin resistance among CNS strains isolated from healthy carriers and hospitalised patients.

  9. Life science applications and research potential of the TwinMic spectromicroscopy station at ELETTRA

    International Nuclear Information System (INIS)

    Since its opening to the users in late 2007, the TwinMic beamline at the Elettra synchrotron has been attracting the interest of a broad life science community. The recent development and implementation of a low energy x-ray fluorescence detection mode have increased the capability and the versatility of the scanning mode of the TwinMic microscope. Now using simultaneously the x-ray transmission and emission detection systems one can perform elemental, absorption and phase contrast imaging that provides complementary chemical and morphological information for the sample under investigation. The recent achievements in the performance of the instrument using combined acquisition modes for characterization of nano and micro-structured biomaterials will be illustrated with selected exemplary results

  10. Department of Energy: MICS (Mathematical Information, and Computational Sciences Division). High performance computing and communications program

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-06-01

    This document is intended to serve two purposes. Its first purpose is that of a program status report of the considerable progress that the Department of Energy (DOE) has made since 1993, the time of the last such report (DOE/ER-0536, {open_quotes}The DOE Program in HPCC{close_quotes}), toward achieving the goals of the High Performance Computing and Communications (HPCC) Program. The second purpose is that of a summary report of the many research programs administered by the Mathematical, Information, and Computational Sciences (MICS) Division of the Office of Energy Research under the auspices of the HPCC Program and to provide, wherever relevant, easy access to pertinent information about MICS-Division activities via universal resource locators (URLs) on the World Wide Web (WWW). The information pointed to by the URL is updated frequently, and the interested reader is urged to access the WWW for the latest information.

  11. Movement and Interaction in Semantic GRIDs : Dynamic Service Generation for Agents in the MIC* Deployment Environment

    OpenAIRE

    Gouaich, Abdelkader; Cerri, Stefano A.

    2004-01-01

    We present in this position paper the foundations of the MIC* model and deployment environment as they have emerged in the last years, relate them to current evolutions on semantic GRID dynamic service generation, as reflected by OGSA/I and, more recently, by WSRF, and propose an integrated view with the previously proposed STROBE model for communicating agents leading to a quite simple yet very promising architecture that may include Human agents in the loop, uninspectable as most artificial...

  12. El cómic español desde 1995

    Directory of Open Access Journals (Sweden)

    Díaz de Guereñu, Juan Manuel

    2011-09-01

    Full Text Available In the last fifteen years comic has changed dramatically in Spain. The small size of the comics industry in the Spanish market doesn’t allow comic creators to turn his job into a profession, but the medium has attained prestige, critical attention on the cultural spaces and a place in the bookstores. Those changes are the consequence of some significant facts of the period: after the extinction of former comic magazines, comic books substituted them as the first format for comics edition, and a number of critical fanzines and self-edited fanzines and magazines were published by the authors themselves. Newborn and independent smallpress, more focused on the aesthetic values than on the economic profits of comics edition, have defined the new author comic, often printed in the format of books and associated to the “graphic novel” label.

    En los últimos quince años, el cómic ha cambiado mucho en España. Aunque el escaso peso de la industria del cómic no permite a los autores vivir como profesionales, el medio ha ganado prestigio, atención crítica en las páginas culturales y un lugar en las librerías. Dichos cambios son consecuencia de algunos hechos significativos del periodo: tras la desaparición de las revistas, las sustituyeron cuadernillos o comic-books como soporte fundamental del cómic, y proliferaron revistas críticas de aficionados y fanzines o revistas autoeditadas por los autores. Nuevas editoriales, pequeñas e independientes, más atentas a los valores estéticos que a los comerciales, han definido el nuevo cómic de autor, a menudo identificado con el formato libro y la etiqueta “novela gráfica”.

  13. Correlation between beta-lactamase production and MIC values against penicillin with coagulase negative staphylococci.

    OpenAIRE

    Narayani T; Shanmugam J; Naseema K; Bhattacharya R; Shyamkrishnan K

    1989-01-01

    Two hundred strains of coagulase negative staphylococci (CNS) isolated from various clinical specimens (116) and healthy hospital personnel (84) were investigated for the production of beta-lactamases by means of three iodometric techniques and correlated with the minimum inhibitory concentration (MIC) values of penicillin-G by agar dilution technique and disc diffusion technique. One hundred and fifty (75.0%) of the 200 strains tested produced beta-lactamases. Seventy two per cent of ...

  14. Deep Spitzer 24mic COSMOS imaging -- I. The evolution of luminous dusty galaxies - Confronting the models

    CERN Document Server

    Le Floc'h, E; Ilbert, O; Riguccini, L; Frayer, D; Salvato, M; Surace, J; Arnouts, S; Feruglio, C; Rodighiero, G; Capak, P; Kartaltepe, J; Heinis, S; Sheth, K; Yan, L; McCracken, H; Thompson, D; Sanders, D; Scoville, N; Koekemoer, A

    2009-01-01

    We present the first results obtained from the identification of ~30,000 sources in the 24mic observations of the COSMOS field at S24>~80muJy. Using accurate photo-z's and extrapolations of the counts at faint fluxes we resolve with unprecedented detail the build-up of the mid-IR background across cosmic ages. We find that ~50% and ~80% of the 24mic background intensity originate from galaxies at z~2) contribute only marginally to the CIB. Assuming flux-limited selections at optical wavelengths, we also find that the fraction of i-band sources with 24mic detection strongly increases up to z~2 as a consequence of the rapid evolution that star-forming galaxies have undergone with lookback time. Nonetheless this rising trend shows a clear break at z~1.3, probably due to k-correction effects implied by the complexity of SEDs in the mid-IR. Finally, we compare our results with the predictions from different models of galaxy formation. We note that semi-analytical formalisms fail to reproduce the redshift distribut...

  15. Determination of halogens and sulfur in high-purity polyimide by IC after digestion by MIC.

    Science.gov (United States)

    Krzyzaniak, Sindy R; Santos, Rafael F; Dalla Nora, Flavia M; Cruz, Sandra M; Flores, Erico M M; Mello, Paola A

    2016-09-01

    In this work, a method for sample preparation of high-purity polyimide was proposed for halogens and sulfur determination by ion chromatography (IC) with conductivity detection and, alternatively, by inductively coupled plasma mass spectrometry (ICP-MS). A relatively high polyimide mass (600mg) was completely digested by microwave-induced combustion (MIC) using 20bar of O2 and 50mmolL(-1) NH4OH as absorbing solution. These conditions allowed final solutions with low carbon content (<10mgL(-1)) and suitable pH for analysis by both IC and ICP-MS. The accuracy was evaluated using a certified reference material of polymer for Cl, Br and S and spike recovery experiments for all analytes. No statistical difference (t-test, 95% of confidence level) was observed between the results obtained for Cl, Br and S by IC after MIC and the certified values. In addition, spike recoveries obtained for F, Cl, Br, I and S ranged from 94% to 101%. The proposed method was suitable for polyimide decomposition for further determination of halogens and sulfur by IC and by ICP-MS (Br and I only). Taking into account the lack of methods and the difficulty of bringing this material into solution, MIC can be considered as a suitable alternative for the decomposition of polyimide for routine quality control of halogens and sulfur using IC or ICP-MS. PMID:27343595

  16. Choosing Health and the inner citadel.

    Science.gov (United States)

    Allmark, P

    2006-01-01

    It is argued in this paper that the latest UK government white paper on public health, Choosing Health, is vulnerable to a charge of paternalism. For some years libertarians have levelled this charge at public health policies. The white paper tries to avoid it by constant reference to informed choice and choice related terms. The implication is that the government aims only to inform the public of health issues; how they respond is up to them. It is argued here, however, that underlying the notion of informed choice is a Kantian, "inner citadel" view of autonomy. According to this view, each of us acts autonomously only when we act in accord with reason. On such a view it is possible to justify coercing, cajoling, and conning people on the basis that their current behaviour is not autonomous because it is subject to forces that cause irrational choice, such as addiction. "Informed choice" in this sense is compatible with paternalism. This paternalism can be seen in public health policies such as deceptive advertising and the treatment of "bad habits" as addictions. Libertarians are bound to object to this. In the concluding section, however, it is suggested that public health can, nonetheless, find ethical succour from alternative approaches. PMID:16373514

  17. Precision of vancomycin and daptomycin MICs for methicillin-resistant Staphylococcus aureus and effect of subculture and storage.

    Science.gov (United States)

    Charlton, Carmen L; Hindler, Janet A; Turnidge, John; Humphries, Romney M

    2014-11-01

    The reproducibility of vancomycin and daptomycin MICs, measured by broth microdilution (BMD) and Etest, was prospectively assessed for 10 methicillin-resistant Staphylococcus aureus (MRSA) isolates from the blood samples from patients on vancomycin therapy. The isolates were tested at the time of isolation from blood and following 5, 10, and 20 subcultures and at 1, 3, 6, and 12 months of storage at -70 °C. The MICs were determined by Etest and BMD using two different manufacturers (BBL and Difco) of cation-adjusted Mueller-Hinton broth (CA-MHB), and using three different drug powders: vancomycin from Sigma, vancomycin from Novation, and daptomycin from Cubist. The antimicrobial concentrations tested were 0.25, 0.5, 0.75, 1.0, 1.5, 2.0, 2.5, 3.0, 3.5, and 4.0 μg/ml. Two isolates were vancomycin intermediate and daptomycin nonsusceptible, and two isolates had reduced susceptibility to vancomycin (BMD MIC, 1.5 or 2.0 μg/ml). The vancomycin MICs were significantly higher in the BBL CA-MHB than those in the Difco CA-MHB, and with Sigma versus Novation vancomycin powder. The daptomycin MICs were also significantly higher in the BBL CA-MHB. The Etest MICs were significantly higher than those obtained by BMD for vancomycin but not for daptomycin. The average precision of the vancomycin BMD MICs when analyzing 20 results was ± 1.10-fold log2 dilutions, and it was ± 1.67-fold for daptomycin (10 results). The average precision for Etest was ± 1.11-fold for vancomycin and ± 1.16-fold for daptomycin. No significant change in MICs was noted following 5, 10, or 20 subcultures or at up to 6 months of frozen storage. However, the vancomycin MICs alone were significantly lower (0.74-fold) following 12 months of frozen storage. From these data, despite variations in CA-MHB and antimicrobial powder, the MIC result precision was <0.5 log2 dilutions in a single laboratory, suggesting that testing interdilution MICs (e.g., MICs between serial 2-fold dilutions) is a possibility. A

  18. 关于Stn∪ I=1 mi-C4的优美性%On the Gracefulness of Graph St∪n i=1 mi-C4

    Institute of Scientific and Technical Information of China (English)

    李长春; 韩兆红; 张国阳

    2007-01-01

    本文就星形树与m-C4并图的优美性进行探讨,证明了当m≥2这类图StpUm-C4是优美图.并对星形树St与n∪ i=1 mi-C4并图Stn∪ i=1 mi-C4的优美性进行探讨.证明了当max mi≥3 i=1,2…,n这类图Stn∪ i=1 mi-C4是优美图.

  19. Macrophage inhibitory cytokine-1 (MIC-1/GDF15 slows cancer development but increases metastases in TRAMP prostate cancer prone mice.

    Directory of Open Access Journals (Sweden)

    Yasmin Husaini

    Full Text Available Macrophage inhibitory cytokine-1 (MIC-1/GDF15, a divergent member of the TGF-β superfamily, is over-expressed by many common cancers including those of the prostate (PCa and its expression is linked to cancer outcome. We have evaluated the effect of MIC-1/GDF15 overexpression on PCa development and spread in the TRAMP transgenic model of spontaneous prostate cancer. TRAMP mice were crossed with MIC-1/GDF15 overexpressing mice (MIC-1(fms to produce syngeneic TRAMP(fmsmic-1 mice. Survival rate, prostate tumor size, histopathological grades and extent of distant organ metastases were compared. Metastasis of TC1-T5, an androgen independent TRAMP cell line that lacks MIC-1/GDF15 expression, was compared by injecting intravenously into MIC-1(fms and syngeneic C57BL/6 mice. Whilst TRAMP(fmsmic-1 survived on average 7.4 weeks longer, had significantly smaller genitourinary (GU tumors and lower PCa histopathological grades than TRAMP mice, more of these mice developed distant organ metastases. Additionally, a higher number of TC1-T5 lung tumor colonies were observed in MIC-1(fms mice than syngeneic WT C57BL/6 mice. Our studies strongly suggest that MIC-1/GDF15 has complex actions on tumor behavior: it limits local tumor growth but may with advancing disease, promote metastases. As MIC-1/GDF15 is induced by all cancer treatments and metastasis is the major cause of cancer treatment failure and cancer deaths, these results, if applicable to humans, may have a direct impact on patient care.

  20. Choose to change maternity weight management pilot.

    Science.gov (United States)

    Lilley, Suzanne; Anderson, Kate; Benbow, Elizabeth

    2014-07-01

    Obesity during pregnancy is associated with increased risk of adverse health outcomes during pregnancy. There is limited research available regarding effective interventions during pregnancy for obese women and this is combined with local inadequate service provision to support obese mothers in Greater Manchester (GM). Choose to Change (CTC) aims to develop, deliver and evaluate a community based weight management programme to limit excessive gestational weight gain. Participants (n=73) referred from January to December 2013 by Community Midwifery Teams (>18years) with a BMI >30 attended a healthy lifestyle intervention (1:1 or group) covering nutrition, physical activity and behaviour change over 12weeks. Baseline measures were weight, Body Mass Index (BMI), Blood Pressure, physical activity, dietary habits and psychological questionnaires measuring anxiety, self-esteem and dis-ordered eating. 28 clients were assigned to intervention (group (n=15), 1:1 (n=13). Mean age 29 (SD=5.78), mean BMI at referral was 38.96 (SD=4.87). Descriptive statistics suggest an average weight gain for clients (excluding drop outs n=12) is 0.94kg (SD=6.65). For those who have completed the programme (n=8) average weight gain was 1.03kg (SD=7.71). Results vary according to intervention type 1:1, 0.04kg (SD=8.82kg), group, 1.52kg (SD=3.17kg). Drop-out rate from referral to assessment was 62%, from assessment to intervention 32% and during intervention 26%. Overall the results of the present pilot study indicate that the CTC healthy lifestyle intervention can limit excessive gestational weight gain. CTC is looking at future directions for development including changing the assessment procedure to improve DORs, further analysis of various mediating factors including BMI and intervention type and exploration of post-measurements to show further improved health outcomes as the programme is rolled out across GM. PMID:26104613

  1. Helping You Choose Quality Nursing and Rehabilitation Center Services

    Science.gov (United States)

    ... About The Joint Commission Joint Commission Officers Our History Reprint Permission ... to Topic Library Helping You Choose Quality Nursing and Rehabilitation Center Services September 13, 2013 When ...

  2. Heterologous expression of membrane proteins: choosing the appropriate host.

    Directory of Open Access Journals (Sweden)

    Florent Bernaudat

    Full Text Available BACKGROUND: Membrane proteins are the targets of 50% of drugs, although they only represent 1% of total cellular proteins. The first major bottleneck on the route to their functional and structural characterisation is their overexpression; and simply choosing the right system can involve many months of trial and error. This work is intended as a guide to where to start when faced with heterologous expression of a membrane protein. METHODOLOGY/PRINCIPAL FINDINGS: The expression of 20 membrane proteins, both peripheral and integral, in three prokaryotic (E. coli, L. lactis, R. sphaeroides and three eukaryotic (A. thaliana, N. benthamiana, Sf9 insect cells hosts was tested. The proteins tested were of various origins (bacteria, plants and mammals, functions (transporters, receptors, enzymes and topologies (between 0 and 13 transmembrane segments. The Gateway system was used to clone all 20 genes into appropriate vectors for the hosts to be tested. Culture conditions were optimised for each host, and specific strategies were tested, such as the use of Mistic fusions in E. coli. 17 of the 20 proteins were produced at adequate yields for functional and, in some cases, structural studies. We have formulated general recommendations to assist with choosing an appropriate system based on our observations of protein behaviour in the different hosts. CONCLUSIONS/SIGNIFICANCE: Most of the methods presented here can be quite easily implemented in other laboratories. The results highlight certain factors that should be considered when selecting an expression host. The decision aide provided should help both newcomers and old-hands to select the best system for their favourite membrane protein.

  3. Multi-Criteria Decision Making Based in Choosing an Appropriate Tractor

    Directory of Open Access Journals (Sweden)

    M.B Lak

    2016-04-01

    Full Text Available Agricultural mechanization goal is to maximize the utility. Establishment of subsidies systemization and Iran incorporation with World Target Organization (WTO, choosing an appropriate technology will be more important. Agricultural development is due to correct mechanization and choosing an appropriate tractor is one of mechanization implementation bases. In the paper, criteria involved in choosing an appropriate tractor were considered according to Hamedan province conditions and the best choice between 11 tractor models was selected regarding to 9 criteria which were analyzed by Technique for Order-Preference by Similarity to Ideal Solution (TOPSIS. The criteria are: drawbar power, hydraulic power, power take off (PTO power, PTO shaft, specific fuel consumption (SFC, speed range, engine standard round per minute, gearbox, and manufacturer. Between the choices, U453 was preferred and recommended as appropriate tractor.

  4. General aspects for choosing the DICOM viewer

    Directory of Open Access Journals (Sweden)

    Afshin Niakan

    2007-08-01

    Full Text Available Most of physicians choose the PACS by its viewer. DICOM Image viewers, the programs that run in workstations, facilitate accessing to the digital im-ages via a DICOM network. A good workstation should be equipped with professional monitors and other hardware requirements. A wide range of DICOM image viewers are available from simple 2D viewers which offer means of manipulating the im-ages (rotate, zoom, brightness, contrast and others to 3D or 4D programs with sophisticated features such as multimodality image fusion, vessel segmentation and computer aided diagnostic tools."nThese programs can be categorized to client-based and web-based viewers. Despite the client-based viewers, which are heavy-weighted programs, equipped with strong features, web-based viewers are usually light-weighted with essential imaging features and suitable for TeleRadiology. Accessing to the digital images via the Internet is the main propose behind a web-based viewer. Web-based viewers may be used for remote consulting when a city or region lacks of native specialists."nAn image viewer as a part of PACS should be in conformance with DICOM standard as communication protocol instated of customized networking. This issue allows the viewer to communicate with any DICOM server and operate as an independent module. Structured Report (SR editor is an essential part of a DICOM viewer. This kind of reporting benefits the archiving system because of small data size in comparison with keeping reports as scanned images or Secondary Capture Images (SC. Also, connection of DICOM viewer to RIS/HIS is important and as our previous experiences in RIS/HIS we connected Payvand DICOM viewer to the RIS/HIS. "nPayvand DICOM viewer has a lot of features and abilities, but for reaching to the high performance image processing by BARCO-EPD collaboration contract, we integrated our DICOM viewer to the VOXAR 3D and now our users have advanced 3D, vessel, cardiac and colon processing, PET CT

  5. Majorizational Choosing of SeveralDifferent Fuzzy Counter Operator

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Different fuzzy reasoning methods were made by choosing different fuzzy operater. This article generally introduced the basic structure of fuzzy controller ,and gave several different fuzzy controllers ,and compared and analyzed different fuzzy counters in theory and computer simulating control and realized majorizational choosing of several fuzzy counters.

  6. Choosing Your China Structure: Foreign-Invested Commercial Enterprises

    Institute of Scientific and Technical Information of China (English)

    RICHARD; HOFFMAN

    2010-01-01

    When choosing an appropriate invest-When choosing an appropriate investment vehicle in China,many factors must be considered,as these will lead to different legal and tax considerations.Once you’ve clearly defined the needs and goals for your

  7. Choose Privacy Week: Educate Your Students (and Yourself) about Privacy

    Science.gov (United States)

    Adams, Helen R.

    2016-01-01

    The purpose of "Choose Privacy Week" is to encourage a national conversation to raise awareness of the growing threats to personal privacy online and in day-to-day life. The 2016 Choose Privacy Week theme is "respecting individuals' privacy," with an emphasis on minors' privacy. A plethora of issues relating to minors' privacy…

  8. Digging up Classroom Dollars on DonorsChoose

    Science.gov (United States)

    Curriculum Review, 2006

    2006-01-01

    Back in 2000, Charles Best was teaching at Wings Academy, an alternative high school in the Bronx, when he got the idea for a Web site where teachers could solicit donations for class projects. With help from his students, DonorsChoose.org soon was born. Last year, the site won Amazon.com's Nonprofit Innovation Award. So far, DonorsChoose has…

  9. Choosing and Using Images in Environmental Science Education

    Science.gov (United States)

    Muthersbaugh, Debbie Smick

    2012-01-01

    Although using images for teaching has been a common practice in science classrooms (Gordon & Pea, 1995) understanding the purpose or how to choose images has not typically been intentional. For this dissertation three separate studies relating to choosing and using images are prepared with environmental science in mind. Each of the studies…

  10. Thread-Level Parallelization and Optimization of NWChem for the Intel MIC Architecture

    Energy Technology Data Exchange (ETDEWEB)

    Shan, Hongzhang; Williams, Samuel; Jong, Wibe de; Oliker, Leonid

    2014-10-10

    In the multicore era it was possible to exploit the increase in on-chip parallelism by simply running multiple MPI processes per chip. Unfortunately, manycore processors' greatly increased thread- and data-level parallelism coupled with a reduced memory capacity demand an altogether different approach. In this paper we explore augmenting two NWChem modules, triples correction of the CCSD(T) and Fock matrix construction, with OpenMP in order that they might run efficiently on future manycore architectures. As the next NERSC machine will be a self-hosted Intel MIC (Xeon Phi) based supercomputer, we leverage an existing MIC testbed at NERSC to evaluate our experiments. In order to proxy the fact that future MIC machines will not have a host processor, we run all of our experiments in tt native mode. We found that while straightforward application of OpenMP to the deep loop nests associated with the tensor contractions of CCSD(T) was sufficient in attaining high performance, significant effort was required to safely and efficiently thread the TEXAS integral package when constructing the Fock matrix. Ultimately, our new MPI OpenMP hybrid implementations attain up to 65x better performance for the triples part of the CCSD(T) due in large part to the fact that the limited on-card memory limits the existing MPI implementation to a single process per card. Additionally, we obtain up to 1.6x better performance on Fock matrix constructions when compared with the best MPI implementations running multiple processes per card.

  11. Development of biological coal gasification (MicGAS process). Final report, May 1, 1990--May 31, 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-12-31

    ARCTECH has developed a novel process (MicGAS) for direct, anaerobic biomethanation of coals. Biomethanation potential of coals of different ranks (Anthracite, bitumious, sub-bitumious, and lignites of different types), by various microbial consortia, was investigated. Studies on biogasification of Texas Lignite (TxL) were conducted with a proprietary microbial consortium, Mic-1, isolated from hind guts of soil eating termites (Zootermopsis and Nasutitermes sp.) and further improved at ARCTECH. Various microbial populations of the Mic-1 consortium carry out the multi-step MicGAS Process. First, the primary coal degraders, or hydrolytic microbes, degrade the coal to high molecular weight (MW) compounds. Then acedogens ferment the high MW compounds to low MW volatile fatty acids. The volatile fatty acids are converted to acetate by acetogens, and the methanogens complete the biomethanation by converting acetate and CO{sub 2} to methane.

  12. What is the 'minimum inhibitory concentration' (MIC) of pexiganan acting on Escherichia coli? - A cautionary case study

    CERN Document Server

    Jepson, Alys K; Ryan, Lloyd; Ryadnov, Maxim G; Poon, Wilson C K

    2016-01-01

    We measured the minimum inhibitory concentration (MIC) of the antimicrobial peptide pexiganan acting on Escherichia coli, and report an intrinsic variability in such measurements. These results led to a detailed study of the effect of pexiganan on the growth curve of E. coli, using a plate reader and manual plating (i.e. time-kill curves). The measured growth curves, together with single-cell observations and peptide depletion assays, suggested that addition of a sub-MIC concentration of pexiganan to a population of this bacterium killed a fraction of the cells, reducing peptide activity during the process, while leaving the remaining cells unaffected. This pharmacodynamic hypothesis suggests a considerable inoculum effect, which we quantified. Our results cast doubt on the use of the MIC as 'a measure of the concentration needed for peptide action' and show how 'coarse-grained' studies at the population level give vital information for the correct planning and interpretation of MIC measurements.

  13. THE CHIRONOMIDAE ASSEMBLAGES IN SOMESUL MIC RIVER (ROMANIA) DURING 1996 AND 1997

    OpenAIRE

    Maria-Monica Tudorancea; C. Tudorancea

    2001-01-01

    The communities of Chironomidae larvae in the Gilau – Gherla sector of the Somesul Mic River (Transylvania, Romania) were studied during 1996 and 1997 in order to compare their species composition and to see if their component species could be good indicators for water quality deterioration. A total of 102 species were recorded, out of which 12 are new records for the Romanian fauna. Four of these species are known only from East Asia and from the North America. Some species such as Chironomu...

  14. Initial steps in the microbially influenced corrosion (MIC) of metallic surfaces in a natural marine environment

    International Nuclear Information System (INIS)

    Immersion of various metal samples in polluted seawater from Tenerife Harbor was followed by microbial attachment as an intermediate step in fouling development. The purpose of this research was to determine the initial steps in MIC by identifying the different microbial species attached to the respective metal or alloy. Image analysis was used to determine the morphologic changes in the metal surfaces. The corrosion products were determined by X-ray diffraction. The open circuit potentials were measured periodically and their variation with time used to assess the electrochemical behavior in the aforementioned marine environment

  15. Mic Check: How the 99% Pitched a Movement from Occupy Wall Street to Occupy Cal

    OpenAIRE

    Bintliff, Jacob

    2012-01-01

    The University of California, Berkeley, became a site of the Occupy Movement in fall 2011. On November 9, the university found itself in the company of financial hubs, civic centers, and parks and plazas the world over when Sproul Plaza was re-appropriated by the sleeping bags and “mic checks” that came to symbolize the disenfranchised majority, "the 99%." Occupy Cal was immediately subject to a brutal suppression of student protest by the police, as both students and the university administr...

  16. Gestión y TPV mostrador de tienda de cómics Riutori

    OpenAIRE

    Navarro Rivas, Isabel; Serrano Morcillo, Roberto

    2015-01-01

    Riutori es una tienda de cómics y merchandising que abrió sus puertas por primera vez en diciembre de 2005. Después de todo este tiempo llevando su gestión con diversas herramientas y queriendo evolucionar hacia el eCommerce, constató la necesidad de centralización de sus datos y en la mejora general de la gestión del comercio queriendo crear un ERP que se ajustara a su modelo de negocio que dista un poco de los que gestionan los software actuales del mercado. Los requisitos principales qu...

  17. Determination Of Appropriate Antibiotic In Bacterial Meningitis Of Children Based On MIC

    OpenAIRE

    Noorbakhsh S; SA Siadati; Rimaz S; Mamishi S.; Haghi Ashtiani T

    2005-01-01

    Background: Bacterial meningitis is one of the most serious infections in infants and children. Three organisms include S.Pneumo;N.mening;H.Influ are the most common cause of meningitis in children between 2M-14y age.Etest is a new method for determination the MIC of some antimicrobial drugs in agarose .This method is useful for some organisms like as S .Pneumo; N.mening; H.Influ;sensitive Streptococcus and anaerobic ;aerobic gram negative. Materials and Methods: In this descriptive cross sec...

  18. Supervisió i control de reactors químics

    OpenAIRE

    Colomer Llamas, David

    2015-01-01

    En el present projecte es pot veure des de zero l’automatització d’un procés de producció que consta de 4 reactors químics CSTR disposats en sèrie. La simulació de les respostes del procés es porta a terme amb el software Matlab SIMULINK, el control es realitza amb el software RSLogix 5000 de Rockwell i el sistema SCADA amb el software System Platform 2014 R2 de Wonderware. Finalment s’integren les 3 parts mitjançant comunicació OPC i es comprova tot el funcionament com si e...

  19. Construction and expression of the eukaryotic expressed plasmid of MIC3 gene from Toxoplasma gondii in IBRS-2 cells

    Institute of Scientific and Technical Information of China (English)

    Tao JIANG; Donglin ZHANG; Hao NIE; Baoan YAO; Junlong ZHAO

    2008-01-01

    The sequence encoding MIC3 was obtained by amplification from genomic DNA of Toxoplasma gondii RH strain and cloned into the vector pMD18-T. The tar-get gene was subcloned into the eukaryotic vector pcDNA3.1 after the identification of pMD18-T-MIC3 by enzyme digesting, PCR amplification and sequencing. Then the target recombinant plasmids pcMIC3 were transfected into IBRS-2 cells, and the positive cells con-taining pcMIC3 plasmids were obtained under the selec-tion of G418. The expressed proteins from the positive cells were detected by SDS-PAGE, Western blot and ELISA. The results showed that the DNA sequence iden-tity was 99.9% between amplified MIC3 and that from GenBank. The molecular weight of the recombinant MIC3 protein with good immuno-activity was about 39.2 ku. These available data would lay the foundation for further studies on DNA vaccine against Toxoplasma gondii.

  20. To Think, To Choose, To Act.

    Science.gov (United States)

    Collins, LeRoy

    Social, political, and business moral issues that impede solving public problems, and the situation in higher education, specifically in Florida, are considered. Problems in society that have a moral impact include the high rate of crime and an ineffective rehabilitation system for convicted criminals, illicit drug traffic, and the strength of…

  1. The coronal structure of Speedy Mic - I: A densely packed prominence system beyond co-rotation

    CERN Document Server

    Dunstone, N J; Cameron, A C; Jardine, M

    2006-01-01

    We present new observations of the prominence system on the K3 dwarf Speedy Mic (BO Mic, HD 197890). Using an improved technique to track the absorption features in H_alpha we find a very active prominence system with approximately ten prominences on the observable hemisphere per rotation. From a total of 25 prominences we find an average axial distance of 2.85+/-0.54 R_* which is twice the co-rotation radius above the stellar surface. We discuss the consequences of these observations on the nature of the supporting magnetic structures. Two consecutive nights, with complete phase coverage, combined with a further night after a three night gap allow us to study the evolution of the prominence system on two different timescales. Several of the prominences have counterparts at similar phases on consecutive nights. During this interval many prominences show evidence for evolution in their heights and phases of observation. Five nights (13 rotation cycles) later we recover many prominences at approximately the sam...

  2. Non-destructive on-line monitoring of MIC (microbially influenced corrosion)

    Energy Technology Data Exchange (ETDEWEB)

    White, D.C. (Oak Ridge National Lab., TN (USA) Tennessee Univ., Knoxville, TN (USA)); Nivens, D.E.; Mittelman, M.W. (Tennessee Univ., Knoxville, TN (USA). Inst. for Applied Microbiology); Chambers, J.Q. (Tennessee Univ., Knoxville, TN (USA). Dept. of Chemistry); King, J.M.H. (Tennessee Univ., Knoxville, TN (USA). Center for Environmental Biotechnology); Sayler, G.S. (Tennessee Univ., Knoxville, TN

    1990-01-01

    The formation of microbial biofilms on metal surfaces with the subsequent increase in heat transfer resistance and the induction of microbially influenced corrosion (MIC) is being increasingly recognized as an extremely important economic and safety problem for industrial water systems. The development of sufficiently rugged and accurate monitoring devices by which biofilm formation and activity of microbial biofilms can be monitored non-destructively, directly in water systems is the goal of this research. This on-line systems would allow the effective utilization of minimal levels of biocides and inhibitors as well as permit in situ testing of materials for MIC resistance. Several non-destructive technologies such as the quartz crystal microbalance (QCM), the attenuated total reflectance-Fourier transforming infrared spectrometer (ATR-FT/IR), and a genetically engineered bacterium containing the lux gene cassette in which its bioluminescence can be used to define its presence on coupons are on-line devices which accurately measure biofilm formation. Corrosion activity can be estimated by electrochemical impedance. 12 refs., 8 figs.

  3. Memory characteristics of poly-Si using MIC as an active layer on glass substrates

    International Nuclear Information System (INIS)

    In this paper the electrical properties of nonvolatile memory (NVM) using multi-stack gate insulators of oxide-nitride-oxynitride (ONOn) and an active layer of low temperature polycrystalline silicon (LTPS) were investigated. From hydrogenated amorphous silicon (a-Si : H), the LTPS thin film with a high crystalline fraction of 96% and a low surface roughness of 1.28 nm was fabricated by metal induced crystallization (MIC) with annealing conditions of 650 0C for 5 h on glass substrates. The LTPS thin film transistor or the NVM had a field effect mobility of (μFE) 10 cm2 V-1 s-1 and a threshold voltage (VTH) of -3.5 V. The results demonstrated that the NVM had a memory window of 1.6 V with a programming and erasing (P/E) voltage of -14 V and 14 V in 1 ms. Moreover, retention properties of the memory were shown to exceed 80% after 10 years. Therefore, the LTPS fabricated by MIC has become a potential material for NVM application which is employed for the system integration of panel displays.

  4. Memory characteristics of poly-Si using MIC as an active layer on glass substrates

    Energy Technology Data Exchange (ETDEWEB)

    Nguyen, Thanh Nga; Jung, Sungwook; Nguyen, Van Duy; Yi, Junsin, E-mail: yi@yurim.skku.ac.k [School of Information and Communication Engineering, Sungkyunkwan University, Suwon, Kyouggi 440-746 (Korea, Republic of)

    2010-03-17

    In this paper the electrical properties of nonvolatile memory (NVM) using multi-stack gate insulators of oxide-nitride-oxynitride (ONOn) and an active layer of low temperature polycrystalline silicon (LTPS) were investigated. From hydrogenated amorphous silicon (a-Si : H), the LTPS thin film with a high crystalline fraction of 96% and a low surface roughness of 1.28 nm was fabricated by metal induced crystallization (MIC) with annealing conditions of 650 {sup 0}C for 5 h on glass substrates. The LTPS thin film transistor or the NVM had a field effect mobility of ({mu}{sub FE}) 10 cm{sup 2} V{sup -1} s{sup -1} and a threshold voltage (V{sub TH}) of -3.5 V. The results demonstrated that the NVM had a memory window of 1.6 V with a programming and erasing (P/E) voltage of -14 V and 14 V in 1 ms. Moreover, retention properties of the memory were shown to exceed 80% after 10 years. Therefore, the LTPS fabricated by MIC has become a potential material for NVM application which is employed for the system integration of panel displays.

  5. Optimizing zonal advection of the Advanced Research WRF (ARW) dynamics for Intel MIC

    Science.gov (United States)

    Mielikainen, Jarno; Huang, Bormin; Huang, Allen H.

    2014-10-01

    The Weather Research and Forecast (WRF) model is the most widely used community weather forecast and research model in the world. There are two distinct varieties of WRF. The Advanced Research WRF (ARW) is an experimental, advanced research version featuring very high resolution. The WRF Nonhydrostatic Mesoscale Model (WRF-NMM) has been designed for forecasting operations. WRF consists of dynamics code and several physics modules. The WRF-ARW core is based on an Eulerian solver for the fully compressible nonhydrostatic equations. In the paper, we will use Intel Intel Many Integrated Core (MIC) architecture to substantially increase the performance of a zonal advection subroutine for optimization. It is of the most time consuming routines in the ARW dynamics core. Advection advances the explicit perturbation horizontal momentum equations by adding in the large-timestep tendency along with the small timestep pressure gradient tendency. We will describe the challenges we met during the development of a high-speed dynamics code subroutine for MIC architecture. Furthermore, lessons learned from the code optimization process will be discussed. The results show that the optimizations improved performance of the original code on Xeon Phi 5110P by a factor of 2.4x.

  6. Study of a new type anode of OLED by MIC poly-Si

    Science.gov (United States)

    Li, Yang; Meng, Zhiguo; Wu, Chunya; Man, Wong; Hoi, Kwok Sing; Xiong, Shaozhen

    2007-11-01

    In this paper, a boron-doped poly-Si crystallized by solution-based metal induced (S-MIC) as the anode of organic light emitting diode (OLED) was studied. The semi-transparent and semi-reflective anode of OLED systemized with the high reflectivity of Al cathode could form a micro-cavity structure with a low Q to improve the efficiency. The maximum luminance efficiency of red OLED made by Alq3: DCJTB (1.5wt %)( 30nm) with the poly-Si anode is 2.66cd/A, higher than that of the OLED with the ITO anodes by 30%. In order to improve the device performance, some key to optimize the character of MIC poly-Si thin film are analyzed theoretically. A new kind of TFT/OLED coupling structure in AMOLED was proposed, in which the pixel electrode of OLED was made by the same poly-Si thin film with its driver TFT's drain electrode. So that this coupling structure will simplify the AMOLED processes flow.

  7. Choosing target segments in multiple emerging markets

    OpenAIRE

    Blanco, Sylvie; Gauthier, Caroline; Fujimoto, Yukiko

    2011-01-01

    International audience; The customer value proposition is the cornerstone of any Business Model. In the case of the creation of new activities, it is of major importance because it is the first brick in the process of developing a platform of activities. Indeed, little exists prior to it whether we are talking about acquired customers, professions, processes and organizational resources or even the choice of strategic positioning. If we consider the specific case of start-ups based on technol...

  8. Best Practices and Processes for Choosing Research Priorities

    Science.gov (United States)

    Briscoe, M. G.

    2015-12-01

    Individuals, teams, departments, organizations, funding agencies, committees, and others all need to select desirable research priorities from many possible alternatives. One cannot do everything, one cannot afford everything, so what to select? Essays and reports since Weinberg (1963) have suggested criteria for choosing science topics. Popper et al (2000) reviewed and summarized all that had gone before in the subject of setting priorities; their main conclusions were that the underlying principles were the promotion of excellence and relevance. Sea Change (2015) from the NRC/OSB focused on four criteria. From most important to least important, they were transformative science, societal impacts, readiness, and partnership potential; these four criteria embodied the essence of the suggestions from Weinberg on, framed with the pragmatism of ORPISS (2007). Getting to the final set of priorities from many candidates involves a sequence of formal or informal processes, only the last of which is the application of the selected, weighted criteria. As developed by professional prioritization experts, the best-practice steps and processes are: Collection of input candidates from the community. Clustering and parsing/rephrasing of the input to eliminate redundancy and repetition and develop statements at a useful level of specificity. (NOTE:there is no counting of input to see how many times a particular topic was mentioned. The goal is diversity in the input, not a popularity contest.) Development of the selection criteria, and weighting the chosen criteria. Application of the selection criteria to the clustered/adjusted candidates. Finally, two more best practices: Do continuing sanity checks, to avoid losing sight of the goals of the effort. Resist the temptation to just sit around a table and talk about it to arrive at the priorities, which depends too much on who the specific members of the prioritization team are, and provides no transparency or explanation of why

  9. Triplex formation on DNA targets: how to choose the oligonucleotide.

    Science.gov (United States)

    Vekhoff, Pierre; Ceccaldi, Alexandre; Polverari, David; Pylouster, Jean; Pisano, Claudio; Arimondo, Paola B

    2008-11-25

    Triplex-forming oligonucleotides (TFOs) are sequence-specific DNA binders. TFOs provide a tool for controlling gene expression or, when attached to an appropriate chemical reagent, for directing DNA damage. Here, we report a set of rules for predicting the best out of five different triple-helical binding motifs (TM, UM, GA, GT, and GU, where M is 5-methyldeoxycytidine and U is deoxyuridine) by taking into consideration the sequence composition of the underlying duplex target. We tested 11 different triplex targets present in genes having an oncogenic role. The rules have predictive power and are very useful in the design of TFOs for antigene applications. Briefly, we retained motifs GU and TM, and when they do form a triplex, TFOs containing G and U are preferred over those containing T and M. In the case of the G-rich TFOs, triplex formation is principally dependent on the percentage of G and the length of the TFO. In the case of the pyrimidine motif, replacement of T with U is destabilizing; triplex formation is dependent on the percentage of T and destabilized by the presence of several contiguous M residues. An equation to choose between a GU and TM motif is given. PMID:18954091

  10. SAFER STERILE COMPOUNDING: Choosing and Using Disinfectants for the Cleanroom.

    Science.gov (United States)

    Kastango, Eric S; Douglass, Kate; Patel, Kedar; Givehchi, Babak; Brister, Paul; Postlewaite, Jay; Taraban, Laura

    2015-01-01

    Compounders worldwide are responsible for ensuring that the sterile preparations they dispense are pure, potent, and safe. To achieve that result, proper cleaning and disinfection of International Organization for Standardization controlled environments must occur. Because those tasks must be performed according to established standards, the compounding pharmacist must research regulatory requirements and appropriate products for use. In this report, we focus on U.S. regulations, guiding entities, and effective products that enable compliance with the increasingly stringent procedures required for pharmaceutical compounding. We also review cleaning and disinfecting processes, discuss the importance of correctly choosing and using disinfectants and/ or sporicidal disinfectants with surface claims in the cleanroom, and provide answers to questions frequently asked by staff who use those agents. In addition, we profile specific disinfectants that are compliant with UnitedStates Pharmacopeia Chapter and current good manufacturing practice standards. Biological safety cabinets and compounding aseptic containment isolators must undergo an additional process that deactivates hazardous drug residues and removes them from the interior surfaces of those devices before they are cleaned and disinfected, but that discussion is beyond the scope of this article.

  11. Pathobiological implications of the expression of EGFR, pAkt, NF-κB and MIC-1 in prostate cancer stem cells and their progenies.

    Directory of Open Access Journals (Sweden)

    Murielle Mimeault

    Full Text Available The progression of prostate cancers (PCs to locally invasive, androgen-independent and metastatic disease states is generally associated with treatment resistance and disease relapse. The present study was undertaken to establish the possibility of using a combination of specific oncogenic products, including epidermal growth factor receptor (EGFR, pAkt, nuclear factor-kappaB (NF-κB and macrophage inhibitory cytokine-1 (MIC-1 as biomarkers and therapeutic targets for optimizing the management of patients with localized PC at earlier disease stages. The immunohistochemical and immunofluorescence data have revealed that the expression levels of EGFR, Ser(473-pAkt, NF-κB p65 and MIC-1 proteins were significantly enhanced in the same subset of 76 cases of prostatic adenocarcinoma specimens during the disease progression and these biomarkers were expressed in a small subpopulation of CD133(+ PC cells and the bulk tumor mass of CD133(- PC cells. Importantly, all of these biomarkers were also overexpressed in 80-100% of 30 PC metastasis bone tissue specimens. Moreover, the results have indicated that the EGF-EGFR signaling pathway can provide critical functions for the self-renewal of side population (SP cells endowed with stem cell-like features from highly invasive WPE1-NB26 cells. Of therapeutic interest, the targeting of EGFR, pAkt, NF-κB or MIC-1 was also effective at suppressing the basal and EGF-promoted prostasphere formation by SP WPE1-NB26 cells, inducing disintegration of SP cell-derived prostaspheres and decreasing the viability of SP and non-SP WPE1-NB26 cell fractions. Also, the targeting of these oncogenic products induced the caspase-dependent apoptosis in chemoresistant SP WPE1-NB26 cells and enhanced their sensibility to the cytotoxic effects induced by docetaxel. These findings suggest that the combined use of EGFR, pAkt, NF-κB and/or MIC-1 may represent promising strategies for improving the accuracy of current diagnostic and

  12. 柔嫩艾美耳球虫EtMIC2的酵母表面展示%Yeast surface display of Eimeria tenella EtMIC2

    Institute of Scientific and Technical Information of China (English)

    孙慧; 刘卿; 张杰; 陈佩佩; 王龙江; 王甜甜; 王方昆; 李宏梅; 肖一红

    2014-01-01

    利用酿酒酵母表面展示系统展示柔嫩艾美耳球虫微线蛋白基因EtMIC2,为下一步研制活载体疫苗奠定基础.参照GenBank中柔嫩艾美耳球虫EtMIC2基因序列设计引物,以柔嫩艾美耳球虫的RNA为模板,利用RT-PCR扩增得到预期长度的产物,双酶切连接到酿酒酵母表面展示的载体pCTCON2,转化大肠杆菌TOP10,提取阳性质粒转化酿酒酵母菌株EBY100,诱导表达后,用抗EtMIC2蛋白质特异性抗体,做间接免疫荧光(IFA)检测EtMIC2蛋白的表达.结果显示,EtMIC2成功展示到酵母细胞表面,测得最佳诱导时间为48 h.

  13. Choose More than 50 Ways to Prevent Type 2 Diabetes

    Science.gov (United States)

    ... 18. Choose veggie toppings like spinach, broccoli, and peppers for your pizza. 19. Try eating foods from ... Stir fry, broil, or bake with non-stick spray or low-salt broth. Cook with less oil ...

  14. Choosing the right health care provider for pregnancy and childbirth

    Science.gov (United States)

    ... Drugs & Supplements Videos & Tools Español You Are Here: Home → Medical Encyclopedia → Choosing the right health care provider for pregnancy and childbirth URL of this page: //medlineplus.gov/ency/patientinstructions/ ...

  15. Application of open-source photogrammetric software MicMac for monitoring surface deformation in laboratory models

    Science.gov (United States)

    Galland, Olivier; Bertelsen, Hâvard S.; Guldstrand, Frank; Girod, Luc; Johannessen, Rikke F.; Bjugger, Fanny; Burchardt, Steffi; Mair, Karen

    2016-04-01

    Quantifying deformation is essential in modern laboratory models of geological systems. This paper presents a new laboratory monitoring method through the implementation of the open-source software MicMac, which efficiently implements photogrammetry in Structure-from-Motion algorithms. Critical evaluation is provided using results from two example laboratory geodesy scenarios: magma emplacement and strike-slip faulting. MicMac automatically processes images from synchronized cameras to compute time series of digital elevation models (DEMs) and orthorectified images of model surfaces. MicMac also implements digital image correlation to produce high-resolution displacements maps. The resolution of DEMs and displacement maps corresponds to the pixel size of the processed images. Using 24 MP cameras, the precision of DEMs and displacements is ~0.05 mm on a 40 × 40 cm surface. Processing displacement maps with Matlab® scripts allows automatic fracture mapping on the monitored surfaces. MicMac also offers the possibility to integrate 3-D models of excavated structures with the corresponding surface deformation data. The high resolution and high precision of MicMac results and the ability to generate virtual 3-D models of complex structures make it a very promising tool for quantitative monitoring in laboratory models of geological systems.

  16. High MICs for Vancomycin and Daptomycin and Complicated Catheter-Related Bloodstream Infections with Methicillin-Sensitive Staphylococcus aureus

    Science.gov (United States)

    Viedma, Esther; Chaves, Fernando; Lalueza, Antonio; Fortún, Jesús; Loza, Elena; Pujol, Miquel; Ardanuy, Carmen; Morales, Isabel; de Cueto, Marina; Resino-Foz, Elena; Morales-Cartagena, Alejandra; Rico, Alicia; Romero, María P.; Orellana, María Ángeles; López-Medrano, Francisco; Fernández-Ruiz, Mario; Aguado, José María

    2016-01-01

    We investigated the prognostic role of high MICs for antistaphylococcal agents in patients with methicillin-sensitive Staphylococcus aureus catheter-related bloodstream infection (MSSA CRBSI). We prospectively reviewed 83 episodes from 5 centers in Spain during April 2011–June 2014 that had optimized clinical management and analyzed the relationship between E-test MICs for vancomycin, daptomycin, oxacillin, and linezolid and development of complicated bacteremia by using multivariate analysis. Complicated MSSA CRBSI occurred in 26 (31.3%) patients; MICs for vancomycin and daptomycin were higher in these patients (optimal cutoff values for predictive accuracy = 1.5 μg/mL and 0.5 μg/mL). High MICs for vancomycin (hazard ratio 2.4, 95% CI 1.2–5.5) and daptomycin (hazard ratio 2.4, 95% CI 1.1–5.9) were independent risk factors for development of complicated MSSA CRBSI. Our data suggest that patients with MSSA CRBSI caused by strains that have high MICs for vancomycin or daptomycin are at increased risk for complications. PMID:27192097

  17. THE CHIRONOMIDAE ASSEMBLAGES IN SOMESUL MIC RIVER (ROMANIA DURING 1996 AND 1997

    Directory of Open Access Journals (Sweden)

    Maria-Monica Tudorancea

    2001-01-01

    Full Text Available The communities of Chironomidae larvae in the Gilau – Gherla sector of the Somesul Mic River (Transylvania, Romania were studied during 1996 and 1997 in order to compare their species composition and to see if their component species could be good indicators for water quality deterioration. A total of 102 species were recorded, out of which 12 are new records for the Romanian fauna. Four of these species are known only from East Asia and from the North America. Some species such as Chironomus thumi, Microcricotopus bicolor, Dicrotendipes nervosus and Dicrotendipes notatus occurred in organically enriched waters. Other species, such as Cricotopus algarum, Cricotopus bicinctus, Cricotopus tremulus and Cricotopus trifasciatus occurred in both clean and organically polluted water which indicate they are not good bioindicators for water quality deterioration.

  18. El turisme gastronòmic : autenticitat i desenvolupament local en zones rurals

    OpenAIRE

    Fusté Forné, Francesc

    2015-01-01

    Un dels turismes especialitzats que està assolint major importància en l’actualitat és el turisme gastronòmic. L’activitat agrícola i ramadera tradicional en l’àmbit del turisme rural està veient com la pràctica turística li guanya terreny, i en aquest sentit la gastronomia representa la integració dels trets característics del paisatge, tant natural com cultural, d’una destinació. No obstant, l’autenticitat pròpia de cada territori ha de fer front a una globalització cada vegada més ferotge,...

  19. ABUNDANCE AND SEASONAL DYNAMICS OF MAYFLY COMMUNITIES (INSECTA: EPHEMEROPTERA FROM SOMESUL MIC RIVER (ROMANIA

    Directory of Open Access Journals (Sweden)

    Milca Petrovici

    2001-01-01

    Full Text Available The collecting of quantitative benthos samples in 1996-1997, at three sampling sites on the Someşul Mic River, allowed the identification of 12 species of 5 families. The highest diversity was found upstream Cluj-Napoca, and it had decreased downstream town, the mayfly being absent downstream Gherla. Baëtis lutheri along with Baëtis vernus, were the dominant species upstream the town. Baëtis vernus was the only species present downstream Cluj Napoca, in every season. The presence of that species, with very low densities, and being the only identified species in some seasons, reflect a high depreciation of the water quality by the city of Cluj-Napoca. This species although known as very pollution tolerant, absent in the benthos of the river after crossing Gherla industrial town.

  20. El Moviment Olímpic i el món acadèmic

    OpenAIRE

    Puig Brandes, Núria

    2011-01-01

    Núria Puig, responsable de Relacions amb les Universitats del CIO, aborda al seu article “El Moviment Olímpic i el món acadèmic” l’important paper que des de la Grècia antiga, però també als orígens del Moviment Olímpic modern, ha tingut el món acadèmic, i més endavant se centra en el paper dels centres d’estudis olímpics a diferents universitats del món i del Centre d’Estudis Olímpics del CIO amb els seus diferents serveis. Núria Puig, responsable de relaciones con las universidades del C...

  1. Considerations for choosing HOT lane delineation techniques

    Energy Technology Data Exchange (ETDEWEB)

    Hlavacek, I.; Vitek, M. [Texas Univ., Austin, TX (United States); Carrizales, J.; Machemehl, R. [Texas Dept. of Transportation, Austin, TX (Canada)

    2007-07-01

    Transportation agencies are looking for ways to move more vehicles with fewer tax dollars. One innovative technique is managed lanes. These are special purpose lanes on highways with controlled access to allow manipulation of service parameters. An example of a managed facility, high-occupancy toll (HOT) lanes are gaining support as a tool for encouraging higher vehicle occupancy while dealing with many of the shortcomings of high-occupancy vehicle (HOV) lanes. Because managed lanes, including HOT lanes, are controlled access facilities and must be separated from general purpose lanes, one of the principle issues is the type of delineation technique that should be used. Though the specifics of delineating a managed lane are numerous, and allow for a wide variety of possibilities, most delineation techniques used can be categorized into three broad types: concrete barriers, buffer separation, and plastic posts. This paper presented the advantages, disadvantages, required and desirable conditions for implementation of each type. The project involved assembling an expert panel to gather collective knowledge of factors and to share experiences and make recommendations regarding delineation device implementation. Panel recommendations and secondary source information were presented as conceptual guidance regarding managed lane delineation measures. Buffer type delineators were found to be least costly in terms of both initial and maintenance costs, and concrete barriers provide the best means of controlling access so they are the best means of guaranteeing toll collection from all users. 11 refs.

  2. Donor Retention in Online Crowdfunding Communities: A Case Study of DonorsChoose.org

    OpenAIRE

    Althoff, Tim; Leskovec, Jure

    2015-01-01

    Online crowdfunding platforms like DonorsChoose.org and Kickstarter allow specific projects to get funded by targeted contributions from a large number of people. Critical for the success of crowdfunding communities is recruitment and continued engagement of donors. With donor attrition rates above 70%, a significant challenge for online crowdfunding platforms as well as traditional offline non-profit organizations is the problem of donor retention. We present a large-scale study of millions ...

  3. Comparison of the MIC 2000 enteric media with API 20 E and conventional methods for identification of Enterobacteriaceae.

    Science.gov (United States)

    Courcol, R J; Husson, M O; Izard, D E; Martin, G R

    1982-09-01

    By using MIC 2000 Enteric Identification Media the identification of Enterobacteriaceae was evaluated. 421 strains of Enterobacteriaceae belonging to 23 taxa were identified by MIC 2000, and the conventional method API 20 E, respectively. The results obtained are almost identical, i.e. 96.2% and 96.7%. Besides, the results showed no statistical difference between the two miniaturized systems (p greater than 0.1). The MIC 2000 Enteric Media are capable of identifying the majority of Enterobacteriaceae with a reasonable degree of reliability. This system appears to be efficient and flexible. It is convenient to determine the minimal inhibitory concentration of the tested strain on the same microplate. PMID:6758421

  4. Minimal inhibitory concentration (MIC determination of disinfectant and/or sterilizing agents

    Directory of Open Access Journals (Sweden)

    Priscila Gava Mazzola

    2009-06-01

    Full Text Available Due to the growing number of outbreaks of infection in hospital and nurseries, it becomes essential to set up a sanitation program that indicates that the appropriate chemical agent was chosen for application in the most effective way. Validating the effectiveness of decontamination and disinfection is an important and often challenging task. In order to study and compare the behavior of selected microorganisms, they were submitted to minimal inhibitory concentration (MIC. The MIC intervals, which reduced bacteria populations over 6 log10, were: 59 to 156 mg/L of quaternary ammonium compounds (QACs; 63 to 10000 mg/L of chlorhexidine; 1375 to 3250 mg/L of glutaraldehyde; 39 to 246 mg/L of formaldehyde; 43750 to 87500 mg/L of ethanol; 1250 to 6250 mg/L of iodine in polyvinyl-pyrolidone complexes, 150 to 4491 mg/L of chlorine-releasing-agents (CRAs and 469 to 2500 mg/L of hydrogen peroxide. Chlorhexidine showed non inhibitory activity over germinating spores. A. calcoaceticus showed resistance to the majority of the agents tested, followed by E. cloacae and S. marcescens.Devido ao número crescente de surtos de infecção hospitalar, torna-se proeminente o estabelecimento de um programa de sanitização que liste os agentes químicos a serem empregados e o modo de aplicação mais efetivo. Validação da eficácia de descontaminação é uma tarefa ao mesmo tempo importante e desafiadora. Para estudar e comparar o comportamento dos microrganismos selecionados foram realizados ensaios de concentração inibitória mínima (CIM. A CIM capaz de reduzir o bioburden inicial (>6 log10 foi: 59 - 156 mg/L de quartenários de amônia; 63 - 10000 mg/L de clorexidina, 1375 - 3250 mg/mL de glutaraldeído, 39 - 246 mg/L de formaldeído, 43750 - 87500 mg/L de etanol 1250 - 6250 mg/L de PVPI, 150 - 4491 mg/L de compostos liberadores de cloro e 469 -2500 mg/L de peróxido de hidrogênio.

  5. In vitro activity of ertapenem versus ceftriaxone against Neisseria gonorrhoeae isolates with highly diverse ceftriaxone MIC values and effects of ceftriaxone resistance determinants: ertapenem for treatment of gonorrhea?

    Science.gov (United States)

    Unemo, Magnus; Golparian, Daniel; Limnios, Athena; Whiley, David; Ohnishi, Makoto; Lahra, Monica M; Tapsall, John W

    2012-07-01

    Clinical resistance to the currently recommended extended-spectrum cephalosporins (ESCs), the last remaining treatment options for gonorrhea, is being reported. Gonorrhea may become untreatable, and new treatment options are crucial. We investigated the in vitro activity of ertapenem, relative to ceftriaxone, against N. gonorrhoeae isolates and the effects of ESC resistance determinants on ertapenem. MICs were determined using agar dilution technique or Etest for international reference strains (n = 17) and clinical N. gonorrhoeae isolates (n = 257), which included the two extensively drug-resistant (XDR) strains H041 and F89 and additional isolates with high ESC MICs, clinical ESC resistance, and other types of clinical high-level and multidrug resistance (MDR). Genetic resistance determinants for ESCs (penA, mtrR, and penB) were sequenced. In general, the MICs of ertapenem (MIC(50) = 0.032 μg/ml; MIC(90) = 0.064 μg/ml) paralleled those of ceftriaxone (MIC(50) = 0.032 μg/ml; MIC(90) = 0.125 μg/ml). The ESC resistance determinants mainly increased the ertapenem MIC and ceftriaxone MIC at similar levels. However, the MIC ranges for ertapenem (0.002 to 0.125 μg/ml) and ceftriaxone (ceftriaxone-resistant isolates (MIC = 0.5 to 4 μg/ml) had ertapenem MICs of 0.016 to 0.064 μg/ml. Accordingly, ertapenem had in vitro advantages over ceftriaxone for isolates with ceftriaxone resistance. These in vitro results suggest that ertapenem might be an effective treatment option for gonorrhea, particularly for the currently identified ESC-resistant cases and possibly in a dual antimicrobial therapy regimen. However, further knowledge regarding the genetic determinants (and their evolution) conferring resistance to both antimicrobials, and clear correlates between genetic and phenotypic laboratory parameters and clinical treatment outcomes, is essential.

  6. Sport, how people choose it: A network analysis approach.

    Science.gov (United States)

    Ferreri, Luca; Ivaldi, Marco; Daolio, Fabio; Giacobini, Mario; Rainoldi, Alberto; Tomassini, Marco

    2015-01-01

    In order to investigate the behaviour of athletes in choosing sports, we analyse data from part of the We-Sport database, a vertical social network that links athletes through sports. In particular, we explore connections between people sharing common sports and the role of age and gender by applying "network science" approaches and methods. The results show a disassortative tendency of athletes in choosing sports, a negative correlation between age and number of chosen sports and a positive correlation between age of connected athletes. Some interesting patterns of connection between age classes are depicted. In addition, we propose a method to classify sports, based on the analyses of the behaviour of people practising them. Thanks to this brand new classifications, we highlight the links of class of sports and their unexpected features. We emphasise some gender dependency affinity in choosing sport classes.

  7. Why do students choose English as a medium of instruction?

    DEFF Research Database (Denmark)

    Lueg, Klarissa; Lueg, Rainer

    2015-01-01

    increases the employability of graduates, they do not sufficiently consider that study strategies differ substantially across social milieus and between the sexes. Failing to account for social distance to the educational system in choosing EMI can foster social inequality, and contribute......Taking a Bourdieusian perspective, this paper analyzes the relevance of social background and capital for choosing English as a medium of instruction (EMI). It focuses on students with a non-native English-language background in a business school setting. While proponents argue that EMI generally...... to the reproduction of elites. Using a survey, we conduct a quasi-experiment in two identical bachelor's degree programs that differ only in their instruction language. Using structural equation modeling, we find that students from higher social strata are much more likely to choose EMI. As suggested...

  8. Choosing a New Telephone System for Your Medical Practice.

    Science.gov (United States)

    Metherell, Brian

    2016-01-01

    E-mail may rule the world in other types of businesses, but for medical practices, the telephone remains the primary mode of communication with patients, specialists, and pharmacies. From making appointments to calling in prescriptions, telephones are essential to patient care. With technology changing very quickly and new capabilities coming into the medical practice, such as telemedicine and Skype, you need to know your options when choosing a new telephone system. The possibilities include on-site, cloud, and hybrid networked solutions. A wide variety of features and capabilities are available, from dozens of vendors. Of course, no matter what telephone solution you choose, you must meet regulatory compliance, particularly HIPAA, and Payment Card Industry Data Security Standard if you take credit cards. And it has to be affordable, reliable, and long lasting. This article explores what medical practices need to know when choosing a new business telephone system in order to find the right solutions for their businesses. PMID:27443060

  9. Postantibiotic Effect and Postantibiotic Sub-MIC Effect of Levofloxacin Compared to Those of Ofloxacin, Ciprofloxacin, Erythromycin, Azithromycin, and Clarithromycin against 20 Pneumococci

    OpenAIRE

    Spangler, Sheila K.; Lin, Gengrong; Jacobs, Michael R.; Appelbaum, Peter C.

    1998-01-01

    The postantibiotic effect (PAE) (10 times the MIC of quinolones, 5 times the MIC of macrolides) and postantibiotic sub-MIC effect (PAE-SME) at 0.125, 0.25, and 0.5 times the MIC were determined for levofloxacin, ciprofloxacin, ofloxacin, erythromycin, azithromycin, and clarithromycin against 20 pneumococci. Quinolone PAEs ranged between 0.5 and 6.5 h, and macrolide PAEs ranged between 1 and 6 h. Measurable PAE-SMEs (in hours) at the three concentrations were 1 to 5, 1 to 8, and 1 to 8, respec...

  10. Postantibiotic effect and postantibiotic sub-MIC effect of levofloxacin compared to those of ofloxacin, ciprofloxacin, erythromycin, azithromycin, and clarithromycin against 20 pneumococci.

    Science.gov (United States)

    Spangler, S K; Lin, G; Jacobs, M R; Appelbaum, P C

    1998-05-01

    The postantibiotic effect (PAE) (10 times the MIC of quinolones, 5 times the MIC of macrolides) and postantibiotic sub-MIC effect (PAE-SME) at 0.125, 0.25, and 0.5 times the MIC were determined for levofloxacin, ciprofloxacin, ofloxacin, erythromycin, azithromycin, and clarithromycin against 20 pneumococci. Quinolone PAEs ranged between 0.5 and 6.5 h, and macrolide PAEs ranged between 1 and 6 h. Measurable PAE-SMEs (in hours) at the three concentrations were 1 to 5, 1 to 8, and 1 to 8, respectively, for quinolones and 1 to 8, 1 to 8, and 1 to 6, respectively, for macrolides. PMID:9593160

  11. Microbially influenced corrosion (MIC) analyses of the BNGS-B vacuum building. Report No. 92-185-K. [BNGS (Bruce Nuclear Generating Station)

    Energy Technology Data Exchange (ETDEWEB)

    Jain, D.K.

    1992-01-01

    Microbially influenced corrosion (MIC) has been found to play a significant role in causing corrosion, especially in those industries which use natural waters. The most significant of the organisms found to cause corrosion are the sulphate-reducing bacteria (SRB), particularly with anoxic deposits or stagnant weirs. In May 1992, the Bruce Nuclear Generating Station B Vacuum Building was inspected for MIC after being in service for 10 years. This report provides results for both on-site MIC inspection and for microbiological analysis of sediments, water, and slime deposits for evidence of MIC bacteria.

  12. [THE ROLE OF COMPUTER TOMOGRAPHY WHILE CHOOSING THE ABDOMINOPLASTY METHOD].

    Science.gov (United States)

    Galych, S P; Symulyk, E V

    2016-03-01

    The role of computer tomography (CT), while choosing the abdominoplasty method in the patients with different types of the anterior abdominal wall deformity present. For CT date the anterior abdominal wall deformity type was determined in the accordance to it--the operation volume needed. Depending on the changes degree the patients were divided on 5 groups, and in accordance to the deformity type present a necessary correction was made. The CT application have had permitted to determine the changes degree in the anterior abdominal wall, and to choose a necessary volume of abdominoplasty precisely. PMID:27514090

  13. Are You Choosing Wisely in Your Professional Practice?

    Science.gov (United States)

    Fessele, Kristen L

    2016-04-01

    To enhance the value of care provided to Americans, the American Board of Internal Medicine and Consumer Reports launched the Choosing Wisely® initiative in 2012. Choosing Wisely educates providers and patients about high-frequency, low-value care practices that can be avoided to decrease cost and increase the value of health care. The Oncology Nursing Society collaborated with the American Academy of Nursing to add the first-ever nursing-focused list to those previously submitted by more than 70 specialty societies.
. PMID:26991717

  14. β-Aescin at subinhibitory concentration (sub-MIC) enhances susceptibility of Candida glabrata clinical isolates to nystatin.

    Science.gov (United States)

    Franiczek, Roman; Gleńsk, Michał; Krzyżanowska, Barbara; Włodarczyk, Maciej

    2015-11-01

    Aescin (escin) derived from the seeds of horse chestnut (Aesculus hippocastanum L.) is a natural mixture of triterpene saponins exhibiting a wide variety of pharmacological properties, including antiinflammatory, analgesic, and antipyretic activities. However, data concerning antifungal activities of these compounds are limited. This study aims to evaluate the in vitro antifungal susceptibility of Candida glabrata clinical isolates to α-aescin sodium, β-aescin crystalline and β-aescin sodium using the disk diffusion (DD) and broth microdilution (BMD) methods. Moreover, the influence of subinhibitory concentration (0.5×MIC) of β-aescins on the nystatin MIC was also studied. In general, the results obtained by the DD assay correlated well with those obtained by the BMD method. Both β-aescins effectively inhibited the growth of all 24 strains tested. The minimum inhibitory concentration (MIC) values ranging from 8 to 32 μg/ml for β-aescin crystalline, whereas those of β-aescin sodium were slightly lower and ranged from 4 to 16 μg/ml. In contrast, α-aescin sodium was found to be completely ineffective against the strains studied. MIC values of nystatin were reduced 2-16-fold and 2-4-fold in the presence of subinhibitory concentration of β-aescin crystalline and β-aescin sodium, respectively. Results of the present study may suggest the additive interaction between β-aescin and nystatin. PMID:26092104

  15. Introducció a l'ús del simulador de processos químics CHEMCAD 5.2.0

    OpenAIRE

    Gómez Siurana, Amparo; Font Escamilla, Alicia; Menargues Irles, Sergio

    2007-01-01

    Es tracta d'un manual on s'explica, mitjançant l'ajuda d'exemples resolts, l'ús del simulador comercial de processos químics Chemcad 5.2.0. Secretariat de Promoció del Valencià, Universitat d'Alacant; Conselleria de Cultura, Educació i Ciència; CAM

  16. Synthesis of 1-Substituted Isoquinolines by Heterocyclization of TosMIC Derivatives: Total Synthesis of Cassiarin A.

    Science.gov (United States)

    Gutiérrez, Sara; Coppola, Anna; Sucunza, David; Burgos, Carolina; Vaquero, Juan J

    2016-07-15

    A new method for the synthesis of 1-substituted isoquinolines by a heterocyclization that involves α-benzyl TosMIC derivatives and different electrophiles has been developed. This methodology has been successfully applied to a total synthesis of cassiarin A, an alkaloid with potent antiplasmodial activity against Plasmodium falciparum. PMID:27351205

  17. Chelsea Boys: paradigmas sexuales de un cómic queer

    Directory of Open Access Journals (Sweden)

    Rafael Manuel Mérida Jiménez

    2009-01-01

    Full Text Available Más allá del barrio neoyorquino que da título a este serie de volúmenes –aunque en diálogo tanto con su realidad como con sus representaciones anteriores, como Rear Window, dónde se presenta ya como espacio sexualizado–; y más allá del estereotipo gay que la misma expresión representa, Chelsea Boys aparece como un espacio de ruptura de clichés. En el contexto del cómic gay norteamericano que se repasa en este artículo, constituye una propuesta plural, donde la universalidad de las situaciones que representa superan tanto el localismo como la rigidez estereotípica de algunas creaciones anteriores. En él emerge una comunidad queer a través de cuya representación se plantean cuestiones cruciales en y para la/s realidad/es gays.

  18. Dust Dynamics and Surface Brightness Profiles of Debris Disks: The Case of AU Mic

    CERN Document Server

    Strubbe, L E; Strubbe, Linda E.; Chiang, Eugene I.

    2005-01-01

    AU Microscopii is a 12-Myr-old M dwarf that harbors an optically thin disk of dust. Within a projected distance b from the star of 43 AU--in the "inner disk"--the scattered-light surface brightness falls as b^-g, where g = 1-2. In the "outer disk," the brightness drops more steeply, with g = 4-5. We devise a theory to explain the entire profile, including the break. Our theory asserts that the AU Mic disk is in steady state and makes no recourse either to unequilibrated cataclysms or to preserved primordial conditions. We posit a ring of parent bodies on circular orbits near 43 AU: the "birth circle." At the birth circle, grains are produced by colliding parent bodies. Grains are removed by the star's wind and radiation, and by destructive grain-grain collisions. Grains having sizes just large enough to remain bound to the star occupy highly eccentric orbits and dominate scattering of starlight in the outer disk. We prove that for large stellocentric radius r, their surface density S scales as r^-5/2. Eccentr...

  19. Extension of the AMBER molecular dynamics software to Intel's Many Integrated Core (MIC) architecture

    Science.gov (United States)

    Needham, Perri J.; Bhuiyan, Ashraf; Walker, Ross C.

    2016-04-01

    We present an implementation of explicit solvent particle mesh Ewald (PME) classical molecular dynamics (MD) within the PMEMD molecular dynamics engine, that forms part of the AMBER v14 MD software package, that makes use of Intel Xeon Phi coprocessors by offloading portions of the PME direct summation and neighbor list build to the coprocessor. We refer to this implementation as pmemd MIC offload and in this paper present the technical details of the algorithm, including basic models for MPI and OpenMP configuration, and analyze the resultant performance. The algorithm provides the best performance improvement for large systems (>400,000 atoms), achieving a ∼35% performance improvement for satellite tobacco mosaic virus (1,067,095 atoms) when 2 Intel E5-2697 v2 processors (2 ×12 cores, 30M cache, 2.7 GHz) are coupled to an Intel Xeon Phi coprocessor (Model 7120P-1.238/1.333 GHz, 61 cores). The implementation utilizes a two-fold decomposition strategy: spatial decomposition using an MPI library and thread-based decomposition using OpenMP. We also present compiler optimization settings that improve the performance on Intel Xeon processors, while retaining simulation accuracy.

  20. Step 7: Choose the "Best" Risk Management Alternative

    Science.gov (United States)

    The ultimate purpose of the SRM tactical phase is to choose how to manage risk. Prior to this stage, we determined the sources of risk, identified the relevant management actions and estimated the likelihood of all known outcomes. Next, we combine this information with your personal risk preference...

  1. Choosing TBM for Tabriz Subway using Multi Criteria Method

    DEFF Research Database (Denmark)

    Edalat, Kamaladdin; Vahdatirad, Mohammadjavad; Ghodrat, Hadi;

    2010-01-01

    in the length of about 20 km and much interference due to tunneling in urban area dictates the appli-cation of TBM. Two kinds of TBM such as EPB (earth pressure balance) and SS (slurry shield) are usually used for urban areas. In this paper, the process of choosing TBM for TURL2 using MCA method (Multi Criteria...

  2. Choosing a Career in Management: An Interdisciplinary Multicultural Perspective

    Science.gov (United States)

    Malach-Pines, Ayala; Ozbilgin, Mustafa F.; Burke, Ronald

    2008-01-01

    Purpose: The purpose of this paper is to introduce the papers in this special issue and some issues surrounding choosing management as a career. A jointly developed questionnaire is also presented. Design/methodology/approach: The paper is descriptive in nature. Findings: It is crucial for researchers and practitioners to expand their perspectives…

  3. Choosing a Strategy for Return-on-Investment Justification.

    Science.gov (United States)

    Foshay, Wellesley R.

    1998-01-01

    Examines the concept of human capital, including how it is linked to strategic analysis and how it relates to four alternative models for return-on-investment (ROI). Discusses how to choose the best model for ROI justification of training or other human performance technology (HPT) interventions. (AEF)

  4. Bending the law and crossing borders choosing Danish sperm

    DEFF Research Database (Denmark)

    Willum Adrian, Stine

    have to apply to the law, it is even possible to choose between anonymous and non-anonymous donors. In this presentation, I focus on how the fertility travellers seeking sperm donation in Denmark, and the employees at Danish fertility clinics and sperm banks, negotiate the ethical implications of using...

  5. Picking and Choosing the ‘Sovereign’Border

    DEFF Research Database (Denmark)

    Parker, Noel; Adler-Nissen, Rebecca

    2012-01-01

    We argue that the continued persistence of borders is an effect of their constitutive role for the many dimensions of a social particular. States cannot choose to have a border; but they can and do make choices amongst the materials available on the various planes of inscription for bordering. Fo...

  6. Choosing a Wiki Platform for Student Projects--Lessons Learned

    Science.gov (United States)

    Malaga, Ross A.

    2010-01-01

    Wikis offer many benefits, such as two-way flows of information, early and consistent feedback, and greater student group collaboration, in an educational setting. Some researchers have already reported on the use of Wikis in their classes. However, instructors must choose an appropriate Wiki platform in order to receive all of the benefits of…

  7. The tiger on your tail: choosing between temporally extended behaviors.

    Science.gov (United States)

    Rosenbaum, David A

    2012-08-01

    The time spent choosing between temporally extended behaviors cannot, in general, last as long as the behaviors themselves; otherwise, the tiger on your tail would have you for lunch. Previous reaction time studies provide little information on this topic, which was explored in the study reported here by showing participants images of scenes for which they could choose a left or right walking-and-reaching path. The paths they chose were nearly identical to ones chosen by participants who actually performed the task in a previous study. Moreover, the times participants took to choose the actions were about 5 times shorter than the times it took to perform them. The choice-time data were inconsistent with the idea that participants picked the path with a lower cost after mentally simulating the paths one after the other. Showing real-world scenes and having participants choose actions for them holds promise for future research in cognitive psychology, ecological psychology, and behavioral ecology. PMID:22810168

  8. CHOOSING A MATHEMATICAL MODEL OF HEAT SUPPLY NETWORK ROUTE

    Directory of Open Access Journals (Sweden)

    V. N. Melkumov

    2012-02-01

    Full Text Available Problem statement. Modern computational technologies allow to develop mathematical modelsfor choosing optimal topology and construction routes of heat supply networks taking into accounta large amount of influencing factors. Important pivots when developing a mathematical model arethe choice of source data representation, of the model of choosing the optimal topology and routeand the computational algorithms for model implementation at computing facilities. The difficultyof choosing a computational method, aside from the nature of topological models, is complicatedby a large amount of limiting factors. This is the reason why the choice of forms of representationof mathematical models and the efficiency of computational methods of their solution is actualwhen used in practical applications.Results. A mathematical model of the cost of construction of heat supply networks has been developedwhich, as opposed to traditional models, leaves the necessary degrees of freedom for determiningacceptable and optimal topology and construction route for account of using multicriterionoptimization. A method of weighted summation has been proposed for usage for combiningraster maps corresponding to different routing criteria.Conclusions. The considered method allows to take account of the whole system of factors influencingthe construction route of heat supply network and to conduct route optimization basedon several criteria, which allows to choose the optimal topology and construction route under theinfluence of multiple external and internal factors.

  9. Choosing early pregnancy termination methods in Urban Mozambique

    NARCIS (Netherlands)

    E.M.H. Mitchell; A. Kwizera; M. Usta; H. Gebreselassie

    2010-01-01

    Little is known about who chooses medication abortion with misoprostol and why. Women seeking early abortion in 5 public hospitals in Maputo, Mozambique were recruited in 2005 and 2006 to explore decision-making strategies, method preferences and experiences with misoprostol and vacuum aspiration fo

  10. How and why do consumers choose their payment methods?

    OpenAIRE

    Stacey L. Schreft

    2006-01-01

    This essay provides an overview of the literature on consumer payment behavior. It considers the state of our understanding of how and why consumers choose their payment methods and what is needed to make more headway in understanding consumer payment decisions. It closes by discussing the policy issues that require that we make progress with payments research.

  11. MILLIMETER EMISSION STRUCTURE IN THE FIRST ALMA IMAGE OF THE AU Mic DEBRIS DISK

    Energy Technology Data Exchange (ETDEWEB)

    MacGregor, Meredith A.; Wilner, David J.; Rosenfeld, Katherine A.; Andrews, Sean M. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Matthews, Brenda; Booth, Mark [Herzberg Institute of Astrophysics, 5072 West Saanich Road, Victoria, BC V9E 2E7 (Canada); Hughes, A. Meredith; Chiang, Eugene; Graham, James R.; Kalas, Paul [Department of Astronomy, 601 Campbell Hall, University of California, Berkeley, CA 94720 (United States); Kennedy, Grant [Institute of Astronomy, University of Cambridge, Madingley Road, Cambridge CB3 0HA (United Kingdom); Sibthorpe, Bruce [SRON Netherlands Institute for Space Research, NL-9747 AD Groningen (Netherlands)

    2013-01-10

    We present 1.3 mm ALMA Cycle 0 observations of the edge-on debris disk around the nearby, {approx}10 Myr old, M-type star AU Mic. These observations obtain 0.''6 (6 AU) resolution and reveal two distinct emission components: (1) the previously known dust belt that extends to a radius of 40 AU and (2) a newly recognized central peak that remains unresolved. The cold dust belt of mass {approx}1 M{sub Moon} is resolved in the radial direction with a rising emission profile that peaks sharply at the location of the outer edge of the 'birth ring' of planetesimals hypothesized to explain the midplane scattered light gradients. No significant asymmetries are discerned in the structure or position of this dust belt. The central peak identified in the ALMA image is {approx}6 times brighter than the stellar photosphere, which indicates an additional emission process in the inner regions of the system. Emission from a stellar corona or activity may contribute, but the observations show no signs of temporal variations characteristic of radio-wave flares. We suggest that this central component may be dominated by dust emission from an inner planetesimal belt of mass {approx}0.01 M{sub Moon}, consistent with a lack of emission shortward of 25 {mu}m and a location {approx}<3 AU from the star. Future millimeter observations can test this assertion, as an inner dust belt should be readily separated from the central star at higher angular resolution.

  12. MIX: a mosaic Asian anthropogenic emission inventory for the MICS-Asia and the HTAP projects

    Directory of Open Access Journals (Sweden)

    M. Li

    2015-12-01

    Full Text Available An anthropogenic emission inventory for Asia is developed for the years 2008 and 2010 to support the Model Inter-Comparison Study for Asia (MICS-Asia and the Task Force on Hemispheric Transport of Air Pollution (TF HTAP projects by a mosaic of up-to-date regional emission inventories. Emissions are estimated for all major anthropogenic sources in 30 countries and regions in Asia. We conducted detailed comparisons of different regional emission inventories and incorporated the best-available ones for each region into the mosaic inventory at a uniform spatial and temporal resolution. We estimate the total Asian emissions of ten species in 2010 as follows: 51.3 Tg SO2, 52.1 Tg NOx, 336.6 Tg CO, 67.0 Tg NMVOC (non-methane volatile organic compounds, 28.8 Tg NH3, 31.7 Tg PM10, 22.7 Tg PM2.5, 3.5 Tg BC, 8.3 Tg OC and 17.3 Pg CO2. Emissions from China and India dominate the emissions of Asia for most of the species. We also estimated Asian emissions in 2006 using the same methodology of MIX. The relative change rates of Asian emissions for the period of 2006–2010 are estimated as follows: −8.0 % for SO2, +19 % for NOx, +4 % for CO, +15 % for NMVOC, +2 % for NH3, −3 % for PM10, −2 % for PM2.5, +6 % for BC, +2 % for OC and +20 % for CO2. Model-ready speciated NMVOC emissions for SAPRC-99 and CB05 mechanisms were developed following a profile-assignment approach. Monthly gridded emissions at a spatial resolution of 0.25° × 0.25° are developed and can be accessed from http://www.meicmodel.org/dataset-mix.

  13. To Choose or Not to Choose Science: Constructions of Desirable Identities among Young People Considering a STEM Higher Education Programme

    Science.gov (United States)

    Holmegaard, Henriette Tolstrup; Madsen, Lene Møller; Ulriksen, Lars

    2014-01-01

    In the literature, there is a general concern that a less number of students choose to study science, technology, engineering or mathematics (STEM). This paper presents results from a Danish longitudinal study which examines students' choice of whether or not to continue studying STEM after upper-secondary school. In particular, this study…

  14. Serum levels of human MIC-1/GDF15 vary in a diurnal pattern, do not display a profile suggestive of a satiety factor and are related to BMI

    DEFF Research Database (Denmark)

    Tsai, Vicky Wang-Wei; Macia, Laurence; Feinle-Bisset, Christine;

    2015-01-01

    The TGF-b superfamily cytokine MIC-1/GDF15 circulates in the blood of healthy humans. Its levels rise substantially in cancer and other diseases and this may sometimes lead to development of an anorexia/cachexia syndrome. This is mediated by a direct action of MIC-1/GDF15 on feeding centres...

  15. Fan Database and Web-tool for Choosing Quieter Spaceflight Fans

    Science.gov (United States)

    Allen, Christopher S.; Burnside, Nathan J.

    2007-01-01

    One critical aspect of designing spaceflight hardware is the selection of fans to provide the necessary cooling. And with efforts to minimize cost and the tendancy to be conservative with the amount of cooling provided, it is easy to choose an overpowered fan. One impact of this is that the fan uses more energy than is necessary. But, the more significant impact is that the hardware produces much more acoustic noise than if an optimal fan was chosen. Choosing the right fan for a specific hardware application is no simple task. It requires knowledge of cooling requirements and various fan performance characteristics as well as knowledge of the aerodynamic losses of the hardware in which the fan is to be installed. Knowledge of the acoustic emissions of each fan as a function of operating condition is also required in order to choose a quieter fan for a given design point. The purpose of this paper is to describe a database and design-tool that have been developed to aid spaceflight hardware developers in choosing a fan for their application that is based on aerodynamic performance and reduced acoustic emissions as well. This web-based-tool provides a limited amount of fan-data, provides a method for selecting a fan based on its projected operating point, and also provides a method for comparing and contrasting aerodynamic performance and acoustic data from different fans. Drill-down techniques are used to display details of the spectral noise characteristics of the fan at specific operation conditions. The fan aerodynamic and acoustic data were acquired at Ames Research Center in the Experimental Aero-Physics Branch's Anechoic Chamber. Acoustic data were acquired according to ANSI Standard S12.11-1987, "Method for the Measurement of Noise Emitted by Small Air-Moving Devices." One significant improvement made to this technique included automation that allows for a significant increase in flow-rate resolution. The web-tool was developed at Johnson Space Center and is

  16. Cómo, cuándo y por qué hicimos un cómic bollo

    Directory of Open Access Journals (Sweden)

    Gema Arquero (Project Manager

    2009-01-01

    Full Text Available Este artículo traza un recorrido por distintos aspectos que desempeñaron un papel destacado en la génesis del cómic Salidas de Emergencia. Sus autoras explican la importancia que su situación personal y el contexto político de la España de 2005 tuvieron en la decisión de iniciar su proyecto creativo, situándonos a la vez en las coordenadas culturales en que éste se inscribe. Con ello, también se lleva a cabo un repaso por distintos productos culturales de temática lésbica, con el que se ponen en evidencia las particularidades de este cómic.

  17. Choosing the Path of Leadership in Occupational Therapy

    Directory of Open Access Journals (Sweden)

    Clark Patrick Heard D.OT Reg. (Ont.

    2014-01-01

    Full Text Available Leadership is vital to the success and sustainability of any group, organization, or profession. Using a qualitative phenomenological methodology, consistent with interpretative phenomenological analysis, this study examines why occupational therapists choose the path of leadership. Data was collected through the completion of semistructured interviews with 10 occupational therapy leaders in Ontario, Canada. This collected data was transcribed verbatim and coded for themes by multiple coders. Several methods were employed to establish trustworthiness. Results identify that a desire to influence the profession or care delivery, a need for personal or career development, and a need for change motivate those occupational therapists who might choose the path of leadership. Recommendations for supporting new or developing leaders include a focus on linking occupational therapy practice and leadership theory at the curriculum and professional levels. Moreover, application of novel approaches to mentorship for new and developing leaders, such as supportive communities of practice, are also considered.

  18. AN ANALYSIS ON CHOOSING A PROPER ECOMMERCE PLATFORM

    Directory of Open Access Journals (Sweden)

    Radu Lixandroiu

    2015-05-01

    Full Text Available Choosing an electronic trading platform is a very important decision when opening an online store. A suitable platform must be able to meet many of the requirements as to not confuse the user. It should provide an online business operation providing tools for managing back-office of technically. There are dozens maybe hundreds of electronic ecommerce platforms available to create an online store, so the decision to choose a platform is difficult. In this article, we tried to compare 19 of the most popular open source ecommerce platforms using a mathematical model based on the platform functionalities. Each of these allows parameterization of an online store in a very short time, with some relatively low cost or close to 0.

  19. Choosing Your China Structure:Foreign-Invested Commercial Enterprises

    Institute of Scientific and Technical Information of China (English)

    RICHARD HOFFMAN

    2010-01-01

    @@ When choosing an appropriate investment vehicle in China,many factors must be considered,as these will lead to different legal and tax considerations.Once you've clearly defined the needs and goals for your China investment,it is time to consider the legal form your China entity should take.Foreign investors have several choices for structuring a China enterprise: the representative office,the joint venture,the wholly foreign-owned enterprise(WFOE)and the foreign-invested commercial enterprise(FICE).These structures have different features that can help or hinder your China venture,so choosing the appropriate vehicle from the outset will be invaluable for the long-term success of any investment.Here we examine the FICE.

  20. Rapid, Low-Technology MIC Determination with Clinical Mycobacterium tuberculosis Isolates by Using the Microplate Alamar Blue Assay

    OpenAIRE

    Franzblau, Scott G.; Witzig, Richard S.; McLaughlin, James C.; Torres, Patricia; Madico, Guillermo; Hernandez, Antonio; Degnan, Michelle T.; Cook, Mary B.; Quenzer, Virginia K.; Ferguson, Robert M.; Gilman, Robert H.

    1998-01-01

    A colorimetric, microplate-based Alamar Blue assay (MABA) method was used to determine the MICs of isoniazid (INH), rifampin, streptomycin (SM), and ethambutol (EMB) for 34 Peruvian Mycobacterium tuberculosis isolates (including both pansensitive and multidrug-resistant strains) and the H37Rv strain by using bacterial suspensions prepared directly from solid media. Results for all isolates were available within 8 days. Discordant results were observed on initial tests for 3 of 16 INH-suscepti...

  1. The BinaMIcS project: understanding the origin of magnetic fields in massive stars through close binary systems

    OpenAIRE

    Alecian, E.; Neiner, C.; Wade, G. A.; Mathis, S.; Bohlender, D.; Cébron, D; Folsom, C.; Grunhut, J.; Bouquin, J. -B. Le; Petit, V.; Sana, H.; Tkachenko, A.; ud-Doula, A.; collaboration, the BinaMIcS

    2014-01-01

    It is now well established that a fraction of the massive (M>8 Msun) star population hosts strong, organised magnetic fields, most likely of fossil origin. The details of the generation and evolution of these fields are still poorly understood. The BinaMIcS project takes an important step towards the understanding of the interplay between binarity and magnetism during the stellar formation and evolution, and in particular the genesis of fossil fields, by studying the magnetic properties of cl...

  2. What Is the Appropriate Meropenem MIC for Screening of Carbapenemase-Producing Enterobacteriaceae in Low-Prevalence Settings?

    Science.gov (United States)

    Fattouh, Ramzi; Tijet, Nathalie; McGeer, Allison; Poutanen, Susan M; Melano, Roberto G; Patel, Samir N

    2016-03-01

    Infection with carbapenemase-producing Enterobacteriaceae (CPE) has been shown to cause significant illness among hospitalized patients. Given the paucity of treatment options, there is a critical need to stop the spread of CPE. However, screening for the presence of CPE in laboratory settings has been challenging. In order to assess the effectiveness of current CPE detection guidelines, we analyzed the meropenem MIC distribution for a large set of clinical Enterobacteriaceae isolates. A total of 1,022 isolates submitted to the Public Health Ontario Laboratories (PHOL) from January 2011 to March 2014 were examined. Only isolates displaying a meropenem or ertapenem MIC of ≥ 0.25 or ≥ 1 μg/ml, respectively, were included. Carbapenemase-positive isolates were identified by multiplex PCR. We identified 189 isolates positive for carbapenemases, which primarily comprised NDM, KPC, and OXA-48-like carbapenemases, and these isolates were largely Klebsiella spp., Escherichia coli, and Enterobacter spp. Interestingly, 14 to 20% of these isolates displayed meropenem MICs within the susceptible range on the basis of CLSI and EUCAST breakpoint interpretive criteria. While the majority of meropenem-susceptible CPE isolates were observed to be E. coli, meropenem susceptibility was not exclusive to any one species/genus or carbapenemase type. Application of CLSI screening recommendations captured only 86% of carbapenemase-producing isolates, whereas application of EUCAST recommendations detected 98.4% of CPE isolates. In a region with a low carbapenemase prevalence, meropenem-based screening approaches require a cutoff MIC near the epidemiological wild-type threshold in order to achieve nearly optimal CPE identification. PMID:26711746

  3. Development of Doxycycline MIC and Disk Diffusion Interpretive Breakpoints and Revision of Tetracycline Breakpoints for Streptococcus pneumoniae

    OpenAIRE

    Dallas, Steven D.; McGee, Lesley; Limbago, Brandi; Patel, Jean B; McElmeel, M. Leticia; Fulcher, Letitia C.; Lonsway, David R.; Jorgensen, James H.

    2013-01-01

    A study was performed to derive susceptibility testing interpretive breakpoints for doxycycline with Streptococcus pneumoniae and to reassess breakpoints for tetracycline using the requirements defined in Clinical and Laboratory Standards Institute (CLSI) document M23-A3. Tetracycline and doxycycline MICs and disk diffusion zone sizes were determined on 189 isolates selected from the 2009-2010 CDC Active Bacterial Core surveillance strain collection according to the testing methods described ...

  4. Chlorhexidine resistance in methicillin-resistant Staphylococcus aureus or just an elevated MIC? An in vitro and in vivo assessment.

    OpenAIRE

    Cookson, B D; Bolton, M C; Platt, J H

    1991-01-01

    Chlorhexidine (Hibiscrub; ICI) is generally accepted to be effective as an antiseptic hand wash for methicillin-susceptible Staphylococcus aureus (MSSA), but there is dispute whether the chlorhexidine MIC for methicillin-resistant S. aureus (MRSA) strains is higher than that for MSSA strains and, indeed, whether it is relevant. In addition, the link between resistance to chlorhexidine, gentamicin, and "nucleic acid-binding" compounds (NAB; which code, in particular, for propamidine isethionat...

  5. Postantibiotic Effect and Postantibiotic Sub-MIC Effect of Quinupristin-Dalfopristin against Gram-Positive and -Negative Organisms

    OpenAIRE

    Pankuch, Glenn A.; Jacobs, Michael R.; Appelbaum, Peter C.

    1998-01-01

    Quinupristin-dalfopristin produced postantibiotic effects (PAEs) and postantibiotic sub-MIC effects of >2 h against 18 gram-positive cocci. Mean pneumococcal and staphylococcal PAEs were 2.8 and 4.7 h, respectively, with shorter PAEs for constitutively than inducibly macrolide-resistant staphylococci. Mean PAEs for vancomycin-susceptible and -resistant Enterococcus faecium were 8.5 and 2.6 h, respectively.

  6. ALGORITHM TO CHOOSE ENERGY GENERATION MULTIPLE ROLE STATION

    Directory of Open Access Journals (Sweden)

    Alexandru STĂNESCU

    2014-05-01

    Full Text Available This paper proposes an algorithm that is based on a complex analysis method that is used for choosing the configuration of a power station. The station generates electric energy and hydrogen, and serves a "green" highway. The elements that need to be considered are: energy efficiency, location, availability of primary energy sources in the area, investment cost, workforce, environmental impact, compatibility with existing systems, meantime between failure.

  7. MEDICAL TOURISTS' EXPECTATIONS WHEN CHOOSING LITHUANIA FOR HEALTH CARE SERVICES

    OpenAIRE

    Miglė Eleonora Černikovaitė; Mantas Jonas Mameniškis

    2015-01-01

    Purpose – Identify medical expectations of tourists choosing Lithuania as medical tourism country and to make comparative analysis with situation in Thailand. Medical tourism is one of the most promising fields of business in the world. International trade in medical services also has huge economic potential and gradually increasing outcome for the global economy (Bookman & Bookman, 2007). Major medical tourism destinations: Thailand, India, Singapore and Malaysia attracted more than 2.5 mill...

  8. I choose health (Elijo Salud: impacting youth through parish nursing.

    Science.gov (United States)

    Oakley, Janet; Hoebeke, Roberta

    2014-01-01

    The 2009-2010 National Health and Nutritional Examination Survey (NHANES) found that 34% of adolescents are overweight and 18% obese. The chance of an overweight/obese adolescent becoming an overweight/obese adult by age 35 is 60%. Hispanic youth are at risk for becoming obese related to eating habits. This paper describes an intervention, I Choose Health (Elijo Salud), with Hispanic church youth.

  9. LiF Reduces MICs of Antibiotics against Clinical Isolates of Gram-Positive and Gram-Negative Bacteria

    Directory of Open Access Journals (Sweden)

    H. C. Syed

    2012-01-01

    Full Text Available Antibiotic resistance is an ever-growing problem yet the development of new antibiotics has slowed to a trickle, giving rise to the use of combination therapy to eradicate infections. The purpose of this study was to evaluate the combined inhibitory effect of lithium fluoride (LiF and commonly used antimicrobials on the growth of the following bacteria: Enterococcus faecalis, Staphyloccoccus aureus, Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii, Klebsiella pneumoniae, Serratia marcescens, and Streptococcus pneumoniae. The in vitro activities of ceftazidime, sulfamethoxazole-trimethoprim, streptomycin, erythromycin, amoxicillin, and ciprofloxacin, doxycycline, alone or combined with LiF were performed by microdilution method. MICs were determined visually following 18–20 h of incubation at 37°C. We observed reduced MICs of antibiotics associated with LiF ranging from two-fold to sixteen-fold. The strongest decreases of MICs observed were for streptomycin and erythromycin associated with LiF against Acinetobacter baumannii and Streptococcus pneumoniae. An eight-fold reduction was recorded for streptomycin against S. pneumoniae whereas an eight-fold and a sixteen-fold reduction were obtained for erythromycin against A. baumannii and S. pneumoniae. This suggests that LiF exhibits a synergistic effect with a wide range of antibiotics and is indicative of its potential as an adjuvant in antibiotic therapy.

  10. Choosing Wisely® in Preventive Medicine: The American College of Preventive Medicine's Top 5 List of Recommendations.

    Science.gov (United States)

    Livingston, Catherine J; Freeman, Randall J; Mohammad, Amir; Costales, Victoria C; Titus, Tisha M; Harvey, Bart J; Sherin, Kevin M

    2016-07-01

    The Choosing Wisely(®) initiative is a national campaign led by the American Board of Internal Medicine Foundation, focused on quality improvement and advancing a dialogue on avoiding wasteful or unnecessary medical tests, procedures, and treatments. The American College of Preventive Medicine (ACPM) Prevention Practice Committee is an active participant in the Choosing Wisely project. The committee created the ACPM Choosing Wisely Task Force to lead the development of ACPM's recommendations with the intention of facilitating wise decisions about the appropriate use of preventive care. After utilizing an iterative process that involved reviewing evidence-based literature, the ACPM Choosing Wisely Task Force developed five recommendations targeted toward overused services within the field of preventive medicine. These include: (1) don't take a multivitamin, vitamin E, or beta carotene to prevent cardiovascular disease or cancer; (2) don't routinely perform prostate-specific antigen-based screening for prostate cancer; (3) don't use whole-body scans for early tumor detection in asymptomatic patients; (4) don't use expensive medications when an equally effective and lower-cost medication is available; and (5) don't perform screening for cervical cancer in low-risk women aged 65 years or older and in women who have had a total hysterectomy for benign disease. The Task Force also reviewed some of the barriers to implementing these recommendations, taking into account the interplay between system and environmental characteristics, and identified specific strategies necessary for timely utilization of these recommendations. PMID:27155735

  11. Discovery and characterization of the first non-coding RNA that regulates gene expression,micF RNA:A historical perspective

    Institute of Scientific and Technical Information of China (English)

    Nicholas; Delihas

    2015-01-01

    The first evidence that RNA can function as a regulator of gene expression came from experiments with prokaryotes in the 1980 s. It was shown that Escherichia coli micF isan independent gene,has its own promoter,and encodes a small non-coding RNA that base pairs with and inhibits translation of a target messenger RNA in response to environmental stress conditions. The mic F RNA was isolated,sequenced and shown to be a primary transcript. In vitro experiments showed binding to the target ompF mR NA. Secondary structure probing revealed an imperfect micF RNA/ompF RNA duplex interaction and the presence of a non-canonical base pair. Several transcription factors,including OmpR,regulate micF transcription in response to environmental factors. micF has also been found in other bacterial species,however,recently Gerhart Wagner and J?rg Vogel showed pleiotropic effects and found micF inhibits expression of multiple target mR NAs; importantly,one is the global regulatory gene lrp. In addition,micF RNA was found to interact with its targets in different ways; it either inhibits ribosome binding or induces degradation of the message. Thus the concept and initial experimental evidence that RNA can regulate gene expression was born with prokaryotes.

  12. The anorectic actions of the TGFβ cytokine MIC-1/GDF15 require an intact brainstem area postrema and nucleus of the solitary tract.

    Directory of Open Access Journals (Sweden)

    Vicky Wang-Wei Tsai

    Full Text Available Macrophage inhibitory cytokine-1 (MIC-1/GDF15 modulates food intake and body weight under physiological and pathological conditions by acting on the hypothalamus and brainstem. When overexpressed in disease, such as in advanced cancer, elevated serum MIC-1/GDF15 levels lead to an anorexia/cachexia syndrome. To gain a better understanding of its actions in the brainstem we studied MIC-1/GDF15 induced neuronal activation identified by induction of Fos protein. Intraperitoneal injection of human MIC-1/GDF15 in mice activated brainstem neurons in the area postrema (AP and the medial (m portion of the nucleus of the solitary tract (NTS, which did not stain with tyrosine hydroxylase (TH. To determine the importance of these brainstem nuclei in the anorexigenic effect of MIC-1/GDF15, we ablated the AP alone or the AP and the NTS. The latter combined lesion completely reversed the anorexigenic effects of MIC-1/GDF15. Altogether, this study identified neurons in the AP and/or NTS, as being critical for the regulation of food intake and body weight by MIC-1/GDF15.

  13. Association between the AUC0-24/MIC Ratio of Vancomycin and Its Clinical Effectiveness: A Systematic Review and Meta-Analysis.

    Directory of Open Access Journals (Sweden)

    Peng Men

    Full Text Available A target AUC0-24/MIC ratio of 400 has been associated with its clinical success when treating Staphylococcus aureus infections but is not currently supported by state-of-the-art evidence-based research.This current systematic review aimed to evaluate the available evidence for the association between the AUC0-24/MIC ratio of vancomycin and its clinical effectiveness on hospitalized patients and to confirm the existing target value of 400.PubMed, Embase, Web of Sciences, the Cochrane Library and two Chinese literature databases (CNKI, CBM were systematically searched. Manual searching was also applied. Both RCTs and observational studies comparing the clinical outcomes of high AUC0-24/MIC groups versus low AUC0-24/MIC groups were eligible. Two reviewers independently extracted the data. The primary outcomes were mortality and infection treatment failure. Risk ratios (RRs with 95% confidence intervals (95%CIs were calculated.No RCTs were retrieved. Nine cohort studies were included in the meta-analysis. Mortality rates were significantly lower in high AUC0-24/MIC groups (RR = 0.47, 95%CI = 0.31-0.70, p<0.001. The rates of infection treatment failure were also significantly lower in high AUC/MIC groups and were consistent after correcting for heterogeneity (RR = 0.39, 95%CI = 0.28-0.55, p = 0.001. Subgroup analyses showed that results were consistent whether MIC values were determined by broth microdilution (BMD method or Etest method. In studies using the BMD method, breakpoints of AUC0-24/MIC all fell within 85% to 115% of 400.This meta-analysis demonstrated that achieving a high AUC0-24/MIC of vancomycin could significantly decrease mortality rates by 53% and rates of infection treatment failure by 61%, with 400 being a reasonable target.

  14. Optimally choosing small ensemble members to produce robust climate simulations

    International Nuclear Information System (INIS)

    This study examines the subset climate model ensemble size required to reproduce certain statistical characteristics from a full ensemble. The ensemble characteristics examined are the root mean square error, the ensemble mean and standard deviation. Subset ensembles are created using measures that consider the simulation performance alone or include a measure of simulation independence relative to other ensemble members. It is found that the independence measure is able to identify smaller subset ensembles that retain the desired full ensemble characteristics than either of the performance based measures. It is suggested that model independence be considered when choosing ensemble subsets or creating new ensembles. (letter)

  15. Categorical and nonparametric data analysis choosing the best statistical technique

    CERN Document Server

    Nussbaum, E Michael

    2014-01-01

    Featuring in-depth coverage of categorical and nonparametric statistics, this book provides a conceptual framework for choosing the most appropriate type of test in various research scenarios. Class tested at the University of Nevada, the book's clear explanations of the underlying assumptions, computer simulations, and Exploring the Concept boxes help reduce reader anxiety. Problems inspired by actual studies provide meaningful illustrations of the techniques. The underlying assumptions of each test and the factors that impact validity and statistical power are reviewed so readers can explain

  16. Microbial induced corrosion (MIC) on DHP copper by Desulfovibrio desulfuricans and Bacillus megaterium strains in media simulating heater waters

    International Nuclear Information System (INIS)

    The complexity and diversity of microbial populations in water heating systems of steam generators make it necessary to study the magnitude of the metabolic activity of bacteria and biofilm development that may lead to degradation of metal components through microbial induced corrosion (MIC). Electrolytes simulating the conditions found in heater water networks were used to induce biofilm formation on DHP copper coupons by Desulfovibrio desulfuricans DSMZ and Bacillus megaterium C10, a commercial strain and an isolate from these waters, respectively. In order to enhance their action, industrial waters enriched with the minimum nutrient content such as sodium lactate and sodium sulphite for the DSMZ strain and glucose, proteose peptone and starch for the C10 strain were employed. Biofilm formation was studied under controlled temperature, time, shaking, pH and concentrations of the media used in this study. Then, the samples were electrochemically tested in an artificial solution of sea water as control medium, based on the hypothesis that the action of an aggressive biofilm/electrolyte medium generates damaged and non-damaged areas on the metal surface, and assuming that the sea water trial can detect the latter. Hence, a higher anodic current was associated with a lower degradation of the metal surface by the action of one of the media under study. All these trials were performed along with bacterial count, scanning electron microscopy (SEM) and atomic absorption spectroscopy (AAS). Furthermore, it was possible to identify under which conditions MIC on DHP copper occurred and complex mechanisms from retention of cations to diffusion processes at the biofilm/tested media interface level were proposed. Surface corrosion by MIC took place on DHP copper; therefore, greater control on the treatment of industrial waters is highly desirable. (author)

  17. Microbial induced corrosion (MIC) on DHP copper by Desulfovibrio desulfuricans and Bacillus megaterium strains in media simulating heater waters

    Energy Technology Data Exchange (ETDEWEB)

    Zumelzu, E.; Cabezas, C.; Schoebitz, R.; Ugarte, R.; Rodriguez, E.D.; Rios, J. [Universidad Austral de Chile, Valdivia (Chile)

    2003-01-01

    The complexity and diversity of microbial populations in water heating systems of steam generators make it necessary to study the magnitude of the metabolic activity of bacteria and biofilm development that may lead to degradation of metal components through microbial induced corrosion (MIC). Electrolytes simulating the conditions found in heater water networks were used to induce biofilm formation on DHP copper coupons by Desulfovibrio desulfuricans DSMZ and Bacillus megaterium C10, a commercial strain and an isolate from these waters, respectively. In order to enhance their action, industrial waters enriched with the minimum nutrient content such as sodium lactate and sodium sulphite for the DSMZ strain and glucose, proteose peptone and starch for the C10 strain were employed. Biofilm formation was studied under controlled temperature, time, shaking, pH and concentrations of the media used in this study. Then, the samples were electrochemically tested in an artificial solution of sea water as control medium, based on the hypothesis that the action of an aggressive biofilm/electrolyte medium generates damaged and non-damaged areas on the metal surface, and assuming that the sea water trial can detect the latter. Hence, a higher anodic current was associated with a lower degradation of the metal surface by the action of one of the media under study. All these trials were performed along with bacterial count, scanning electron microscopy (SEM) and atomic absorption spectroscopy (AAS). Furthermore, it was possible to identify under which conditions MIC on DHP copper occurred and complex mechanisms from retention of cations to diffusion processes at the biofilm/tested media interface level were proposed. Surface corrosion by MIC took place on DHP copper; therefore, greater control on the treatment of industrial waters is highly desirable. (author)

  18. The best motivator priorities parents choose via analytical hierarchy process

    Science.gov (United States)

    Farah, R. N.; Latha, P.

    2015-05-01

    Motivation is probably the most important factor that educators can target in order to improve learning. Numerous cross-disciplinary theories have been postulated to explain motivation. While each of these theories has some truth, no single theory seems to adequately explain all human motivation. The fact is that human beings in general and pupils in particular are complex creatures with complex needs and desires. In this paper, Analytic Hierarchy Process (AHP) has been proposed as an emerging solution to move towards too large, dynamic and complex real world multi-criteria decision making problems in selecting the most suitable motivator when choosing school for their children. Data were analyzed using SPSS 17.0 ("Statistical Package for Social Science") software. Statistic testing used are descriptive and inferential statistic. Descriptive statistic used to identify respondent pupils and parents demographic factors. The statistical testing used to determine the pupils and parents highest motivator priorities and parents' best priorities using AHP to determine the criteria chosen by parents such as school principals, teachers, pupils and parents. The moderating factors are selected schools based on "Standard Kualiti Pendidikan Malaysia" (SKPM) in Ampang. Inferential statistics such as One-way ANOVA used to get the significant and data used to calculate the weightage of AHP. School principals is found to be the best motivator for parents in choosing school for their pupils followed by teachers, parents and pupils.

  19. "Choosing the larger versus choosing the smaller: Asymmetries in the size congruity effect": Correction to Arend and Henik (2015).

    Science.gov (United States)

    2016-07-01

    Reports an error in "Choosing the larger versus choosing the smaller: Asymmetries in the size congruity effect" by Isabel Arend and Avishai Henik (Journal of Experimental Psychology: Learning, Memory, and Cognition, 2015[Nov], Vol 41[6], 1821-1830). In the article the wrong version of Figure 1 was published. The correct version is provided. (The following abstract of the original article appeared in record 2015-23893-001.) The size congruity effect (SiCE) shows that number and physical size interact as magnitudes. That is, response times are faster when number and size are congruent (e.g., 2 4) than when they are incongruent (e.g., 2 4). A shared representational system has been the most influential account for the SiCE. Recently, this account has been challenged by findings showing that the SiCE may be influenced by attention. The attentional contribution to the SiCE suggests that the effect is produced by an attention capture effect to the larger stimulus. Even though plausible, the attentional account overlooks 2 important factors in the study of magnitudes, namely, task (numerical vs. physical) and polarity of instructions (choose the larger vs. the smaller). We studied the influence of these factors using a size congruity task. Experiment 1 showed that the SiCE was modulated by task and instructions. In Experiment 2, we used a new set of numbers to examine a possible influence of the so-called end effect (i.e., responses to the smallest and to the largest numbers may not require number comparison). Experiment 2 successfully replicated the pattern of Experiment 1. We suggest that both feature saliency and long-term semantic processes modulate the SiCE. (PsycINFO Database Record PMID:27359227

  20. La vida imaginaria del científico. El caso del cómic 'The Manhattan Projects'

    OpenAIRE

    Sáez de Adana Herrero, Francisco

    2014-01-01

    Aquest article analitza The Manhattan Projects, sèrie de còmics que explica una història alternativa sobre el final de la Segona Guerra Mundial en què el Projecte Manhattan amaga altres activitats més relacionades amb la ciència-ficció. Aquest treball analitza la translació del concepte de vida imaginària encunyat per Marcel Schwob a la història de la ciència en el segle XX.

  1. Comparative Bacteriological Efficacy of Pharmacokinetically Enhanced Amoxicillin-Clavulanate against Streptococcus pneumoniae with Elevated Amoxicillin MICs and Haemophilus influenzae

    OpenAIRE

    Berry, Valerie; Hoover, Jennifer; Singley, Christine; Woodnutt, Gary

    2005-01-01

    A new pharmacokinetically enhanced formulation of amoxicillin-clavulanate (2,000 mg of amoxicillin/125 mg of clavulanate twice a day; ratio 16:1) has been designed, with sustained-release technology, to allow coverage of bacterial strains with amoxicillin-clavulanic acid MICs of at least 4/2 μg/ml. The bacteriological efficacy of amoxicillin-clavulanate, 2,000/125 mg twice a day, ratio 16:1, was compared in a rat model of respiratory tract infection versus four other amoxicillin-clavulanate f...

  2. A new MIC1-MAG1 recombinant chimeric antigen can be used instead of the Toxoplasma gondii lysate antigen in serodiagnosis of human toxoplasmosis.

    Science.gov (United States)

    Holec-Gąsior, Lucyna; Ferra, Bartłomiej; Drapała, Dorota; Lautenbach, Dariusz; Kur, Józef

    2012-01-01

    This study presents an evaluation of the MIC1 (microneme protein 1)-MAG1 (matrix antigen 1) Toxoplasma gondii recombinant chimeric antigen for the serodiagnosis of human toxoplasmosis for the first time. The recombinant MIC1-MAG1 antigen was obtained as a fusion protein containing His tags at the N- and C-terminal ends using an Escherichia coli expression system. After purification by metal affinity chromatography, the chimeric protein was tested for usefulness in an enzyme-linked immunosorbent assay (ELISA) for the detection of anti-T. gondii immunoglobulin G (IgG). One hundred ten sera from patients at different stages of infection and 40 sera from seronegative patients were examined. The results obtained for the MIC1-MAG1 chimeric antigen were compared with those of IgG ELISAs using a Toxoplasma lysate antigen (TLA), a combination of recombinant antigens (rMIC1ex2-rMAG1) and single recombinant proteins (rMIC1ex2 and rMAG1). The sensitivity of the IgG ELISA calculated from all of the positive serum samples was similar for the MIC1-MAG1 chimeric antigen (90.8%) and the TLA (91.8%), whereas the sensitivities of the other antigenic samples used were definitely lower, at 69.1% for the mixture of antigens, 75.5% for the rMIC1ex2, and 60% for rMAG1. This study demonstrates that the MIC1-MAG1 recombinant chimeric antigen can be used instead of the TLA in the serodiagnosis of human toxoplasmosis.

  3. The relationship between inhibition of bacterial adhesion to a solid surface by sub-MICs of antibiotics and subsequent development of a biofilm

    OpenAIRE

    Cerca, Nuno; Martins, Silvia; Pier, Gerald B.; Oliveira, Rosário; Azeredo, Joana

    2005-01-01

    Many studies have demonstrated that subminimal inhibitory concentrations (sub-MICs) of antibiotics can inhibit initial microbial adherence to medical device surfaces. It has been suggested that, by inhibiting initial adhesion, biofilm formation might be prevented. However, since initial adherence and subsequent biofilm formation may be two distinct phenomena, conclusions regarding the effects of sub-MIC antibiotics on initial adhesion cannot be extrapolated to biofilm formation. In t...

  4. 20 CFR 702.403 - Employee's right to choose physician; limitations.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Employee's right to choose physician... PROCEDURE Medical Care and Supervision § 702.403 Employee's right to choose physician; limitations. The employee shall have the right to choose his/her attending physician from among those authorized by...

  5. [Strategies to choose scaffold materials for tissue engineering].

    Science.gov (United States)

    Gao, Qingdong; Zhu, Xulong; Xiang, Junxi; Lü, Yi; Li, Jianhui

    2016-02-01

    Current therapies of organ failure or a wide range of tissue defect are often not ideal. Transplantation is the only effective way for long time survival. But it is hard to meet huge patients demands because of donor shortage, immune rejection and other problems. Tissue engineering could be a potential option. Choosing a suitable scaffold material is an essential part of it. According to different sources, tissue engineering scaffold materials could be divided into three types which are natural and its modified materials, artificial and composite ones. The purpose of tissue engineering scaffold is to repair the tissues or organs damage, so could reach the ideal recovery in its function and structure aspect. Therefore, tissue engineering scaffold should even be as close as much to the original tissue or organs in function and structure. We call it "organic scaffold" and this strategy might be the drastic perfect substitute for the tissues or organs in concern. Optimized organization with each kind scaffold materials could make up for biomimetic structure and function of the tissue or organs. Scaffold material surface modification, optimized preparation procedure and cytosine sustained-release microsphere addition should be considered together. This strategy is expected to open new perspectives for tissue engineering. Multidisciplinary approach including material science, molecular biology, and engineering might find the most ideal tissue engineering scaffold. Using the strategy of drawing on each other strength and optimized organization with each kind scaffold material to prepare a multifunctional biomimetic tissue engineering scaffold might be a good method for choosing tissue engineering scaffold materials. Our research group had differentiated bone marrow mesenchymal stem cells into bile canaliculi like cells. We prepared poly(L-lactic acid)/poly(ε-caprolactone) biliary stent. The scaffold's internal played a part in the long-term release of cytokines which

  6. Rapid, low-technology MIC determination with clinical Mycobacterium tuberculosis isolates by using the microplate Alamar Blue assay.

    Science.gov (United States)

    Franzblau, S G; Witzig, R S; McLaughlin, J C; Torres, P; Madico, G; Hernandez, A; Degnan, M T; Cook, M B; Quenzer, V K; Ferguson, R M; Gilman, R H

    1998-02-01

    A colorimetric, microplate-based Alamar Blue assay (MABA) method was used to determine the MICs of isoniazid (INH), rifampin, streptomycin (SM), and ethambutol (EMB) for 34 Peruvian Mycobacterium tuberculosis isolates (including both pansensitive and multidrug-resistant strains) and the H37Rv strain by using bacterial suspensions prepared directly from solid media. Results for all isolates were available within 8 days. Discordant results were observed on initial tests for 3 of 16 INH-susceptible isolates, 5 of 31 EMB-susceptible isolates, and 2 of 4 SM-resistant isolates (by the BACTEC 460 system). The overall agreements between the MICs obtained by MABA and the results obtained with the BACTEC 460 system were 87.9% for initial results and 93.6% after retesting 12 of 17 samples with discrepant results. Interpretation of MABA endpoints improved with technical experience. The MABA is a simple, rapid, low-cost, appropriate technology which does not require expensive instrumentation and which makes use of a nontoxic, temperature-stable reagent. PMID:9466742

  7. The BinaMIcS project: understanding the origin of magnetic fields in massive stars through close binary systems

    CERN Document Server

    Alecian, E; Wade, G A; Mathis, S; Bohlender, D; Cébron, D; Folsom, C; Grunhut, J; Bouquin, J -B Le; Petit, V; Sana, H; Tkachenko, A; ud-Doula, A

    2014-01-01

    It is now well established that a fraction of the massive (M>8 Msun) star population hosts strong, organised magnetic fields, most likely of fossil origin. The details of the generation and evolution of these fields are still poorly understood. The BinaMIcS project takes an important step towards the understanding of the interplay between binarity and magnetism during the stellar formation and evolution, and in particular the genesis of fossil fields, by studying the magnetic properties of close binary systems. The components of such systems are most likely formed together, at the same time and in the same environment, and can therefore help us to disentangle the role of initial conditions on the magnetic properties of the massive stars from other competing effects such as age or rotation. We present here the main scientific objectives of the BinaMIcS project, as well as preliminary results from the first year of observations from the associated ESPaDOnS and Narval spectropolarimetric surveys.

  8. The BinaMIcS project: understanding the origin of magnetic fields in massive stars through close binary systems

    Science.gov (United States)

    Alecian, E.; Neiner, C.; Wade, G. A.; Mathis, S.; Bohlender, D.; Cébron, D.; Folsom, C.; Grunhut, J.; Le Bouquin, J.-B.; Petit, V.; Sana, H.; Tkachenko, A.; ud-Doula, A.

    2015-01-01

    It is now well established that a fraction of the massive (M > 8 M ⊙) star population hosts strong, organised magnetic fields, most likely of fossil origin. The details of the generation and evolution of these fields are still poorly understood. The BinaMIcS project takes an important step towards the understanding of the interplay between binarity and magnetism during the stellar formation and evolution, and in particular the genesis of fossil fields, by studying the magnetic properties of close binary systems. The components of such systems are most likely formed together, at the same time and in the same environment, and can therefore help us to disentangle the role of initial conditions on the magnetic properties of the massive stars from other competing effects such as age or rotation. We present here the main scientific objectives of the BinaMIcS project, as well as preliminary results from the first year of observations from the associated ESPaDOnS and Narval spectropolarimetric surveys.

  9. GPU/MIC Acceleration of the LHC High Level Trigger to Extend the Physics Reach at the LHC

    Energy Technology Data Exchange (ETDEWEB)

    Halyo, Valerie [Princeton Univ., NJ (United States); Tully, Christopher [Princeton Univ., NJ (United States)

    2015-04-14

    The quest for rare new physics phenomena leads the PI [3] to propose evaluation of coprocessors based on Graphics Processing Units (GPUs) and the Intel Many Integrated Core (MIC) architecture for integration into the trigger system at LHC. This will require development of a new massively parallel implementation of the well known Combinatorial Track Finder which uses the Kalman Filter to accelerate processing of data from the silicon pixel and microstrip detectors and reconstruct the trajectory of all charged particles down to momentums of 100 MeV. It is expected to run at least one order of magnitude faster than an equivalent algorithm on a quad core CPU for extreme pileup scenarios of 100 interactions per bunch crossing. The new tracking algorithms will be developed and optimized separately on the GPU and Intel MIC and then evaluated against each other for performance and power efficiency. The results will be used to project the cost of the proposed hardware architectures for the HLT server farm, taking into account the long term projections of the main vendors in the market (AMD, Intel, and NVIDIA) over the next 10 years. Extensive experience and familiarity of the PI with the LHC tracker and trigger requirements led to the development of a complementary tracking algorithm that is described in [arxiv: 1305.4855], [arxiv: 1309.6275] and preliminary results accepted to JINST.

  10. The freedom to choose neutron star magnetic field equilibria

    CERN Document Server

    Glampedakis, Kostas

    2016-01-01

    Our ability to interpret and glean useful information from the large body of observations of strongly magnetised neutron stars rests largely on our theoretical understanding of magnetic field equilibria. We answer the following question: is one free to arbitrarily prescribe magnetic equilibria such that fluid degrees of freedom can balance the equilibrium equations? We examine this question for various models for neutron star matter; from the simplest single-fluid barotrope to more realistic non-barotropic multifluid models with superfluid/superconducting components, muons and entropy. We do this for both axi- and non-axisymmetric equilibria, and in Newtonian gravity and general relativity. We show that, in axisymmetry, the most realistic model allows complete freedom in choosing a magnetic field equilibrium whereas non-axisymmetric equilibria are never completely arbitrary.

  11. The freedom to choose neutron star magnetic field equilibria

    Science.gov (United States)

    Glampedakis, Kostas; Lasky, Paul D.

    2016-08-01

    Our ability to interpret and glean useful information from the large body of observations of strongly magnetised neutron stars rests largely on our theoretical understanding of magnetic field equilibria. We answer the following question: is one free to arbitrarily prescribe magnetic equilibria such that fluid degrees of freedom can balance the equilibrium equations? We examine this question for various models for neutron star matter; from the simplest single-fluid barotrope to more realistic non-barotropic multifluid models with superfluid/superconducting components, muons and entropy. We do this for both axi- and non-axisymmetric equilibria, and in Newtonian gravity and general relativity. We show that, in axisymmetry, the most realistic model allows complete freedom in choosing a magnetic field equilibrium whereas non-axisymmetric equilibria are never completely arbitrary.

  12. Choosing the right system to manage electricity derivatives

    International Nuclear Information System (INIS)

    The alternatives available and the considerations entering into the choice of the right system to manage electricity derivatives are reviewed. The choice of system will be influenced by a variety of factors, among them : (1) business issues, (2) business processes, (3) functionality, (4) technology, (5) integration into the enterprise, and (6) internal and external competition. The system chosen will need to be integrated into the enterprise. Beyond that,it will need executive commitment, dedicated internal resources, qualified assistance from the vendor, willingness to revisit the business processes and make changes when needed, and training and more training. Some factors to take into account when choosing a system vendor are also discussed. Among these good fit to business, system performance, flexibility, reliability, and customization capacity are the most important

  13. MEDICAL TOURISTS' EXPECTATIONS WHEN CHOOSING LITHUANIA FOR HEALTH CARE SERVICES

    Directory of Open Access Journals (Sweden)

    Miglė Eleonora Černikovaitė

    2015-07-01

    Full Text Available Purpose – Identify medical expectations of tourists choosing Lithuania as medical tourism country and to make comparative analysis with situation in Thailand. Medical tourism is one of the most promising fields of business in the world. International trade in medical services also has huge economic potential and gradually increasing outcome for the global economy (Bookman & Bookman, 2007. Major medical tourism destinations: Thailand, India, Singapore and Malaysia attracted more than 2.5 million medical travellers (United Nations Economic and Social Commission for Asia and the Pacific, 2008. Lithuania is among the major emerging markets in medical tourism that is increasing every year. This study showed that main factors of attracting tourist to Lithuania: fast service and exceptional patient care, the high-tech medical equipment, good prices both for medical and travel services. Comparing to Thailand situation, Lithuania is attractive to the most medical tourist, because of the good quality services with affordable prices and location, while people choosing Thailand – mainly is affected by advertising. The main recommendation for attracting medical tourists to Lithuania is to initiate the advertising campaign to the targeted audiences. Design/methodology/approach – The comparative analysis of scientific literature and empirical comparative quantitative research was executed for acquiring the expectations for medical tourists in Lithuania. Findings – Overview of health and medical tourism situation in Lithuania and other emerging markets. This study showed that main factors of attracting tourist to Lithuania: fast service and exceptional patient care, the high-tech medical equipment, good prices both for medical and travel services and other. Comparative empirical analysis of medical tourist expectations in Lithuania and Thailand. Comparing to Thailand situation, Lithuania is attractive to the most medical tourist, because of the good

  14. Choosing a Commercial Broiler Strain Based on Multicriteria Decision Analysis

    Directory of Open Access Journals (Sweden)

    Hosseini SA

    2014-05-01

    Full Text Available With the complexity and amount of information in a wide variety of comparative performance reports in poultry production, making a decision is difficult. This problem is overcomed only when all data can be put into a common unit. For this purpose, five different decision making analysis approaches including  Maximin, Equally likely, Weighted average, Ordered weighted averages and Technique for order preference by similarity to ideal solution were used to choose the best broiler strain among three ones based on their comparative performance and carcass characteristics. Commercial broiler strains of 6000 designated as R, A, and C (each strain 2000 were randomly allocated into three treatments of five replicates. In this study, all methods showed similar results except Maximin approach. Comparing different methods indicated that strain C with the highest world share market has the best performance followed by strains R and A.

  15. Evaluation of Oxacillin and Cefoxitin Disk and MIC Breakpoints for Prediction of Methicillin Resistance in Human and Veterinary Isolates of Staphylococcus intermedius Group.

    Science.gov (United States)

    Wu, M T; Burnham, C-A D; Westblade, L F; Dien Bard, J; Lawhon, S D; Wallace, M A; Stanley, T; Burd, E; Hindler, J; Humphries, R M

    2016-03-01

    Staphylococcus pseudintermedius is a coagulase-positive species that colonizes the nares and anal mucosa of healthy dogs and cats. Human infections with S. pseudintermedius range in severity from bite wounds and rhinosinusitis to endocarditis; historically, these infections were thought to be uncommon, but new laboratory methods suggest that their true incidence is underreported. Oxacillin and cefoxitin disk and MIC tests were evaluated for the detection of mecA- or mecC-mediated methicillin resistance in 115 human and animal isolates of the Staphylococcus intermedius group (SIG), including 111 Staphylococcus pseudintermediusand 4 Staphylococcus delphini isolates, 37 of which were mecA positive. The disk and MIC breakpoints evaluated included the Clinical and Laboratory Standards Institute (CLSI) M100-S25 Staphylococcus aureus/Staphylococcus lugdunensis oxacillin MIC breakpoints and cefoxitin disk and MIC breakpoints, the CLSI M100-S25 coagulase-negative Staphylococcus (CoNS) oxacillin MIC breakpoint and cefoxitin disk breakpoint, the CLSI VET01-S2 S. pseudintermedius oxacillin MIC and disk breakpoints, and the European Committee on Antimicrobial Susceptibility Testing (EUCAST) S. pseudintermedius cefoxitin disk breakpoint. The oxacillin results interpreted by the VET01-S2 (disk and MIC) and M100-S25 CoNS (MIC) breakpoints agreed with the results of mecA/mecC PCR for all isolates, with the exception of one false-resistant result (1.3% of mecA/mecC PCR-negative isolates). In contrast, cefoxitin tests performed poorly, ranging from 3 to 89% false susceptibility (very major errors) and 0 to 48% false resistance (major errors). BD Phoenix, bioMérieux Vitek 2, and Beckman Coulter MicroScan commercial automated susceptibility test panel oxacillin MIC results were also evaluated and demonstrated >95% categorical agreement with mecA/mecC PCR results if interpreted by using the M100-S25 CoNS breakpoint. The Alere penicillin-binding protein 2a test accurately detected all

  16. Evaluation of Oxacillin and Cefoxitin Disk and MIC Breakpoints for Prediction of Methicillin Resistance in Human and Veterinary Isolates of Staphylococcus intermedius Group.

    Science.gov (United States)

    Wu, M T; Burnham, C-A D; Westblade, L F; Dien Bard, J; Lawhon, S D; Wallace, M A; Stanley, T; Burd, E; Hindler, J; Humphries, R M

    2016-03-01

    Staphylococcus pseudintermedius is a coagulase-positive species that colonizes the nares and anal mucosa of healthy dogs and cats. Human infections with S. pseudintermedius range in severity from bite wounds and rhinosinusitis to endocarditis; historically, these infections were thought to be uncommon, but new laboratory methods suggest that their true incidence is underreported. Oxacillin and cefoxitin disk and MIC tests were evaluated for the detection of mecA- or mecC-mediated methicillin resistance in 115 human and animal isolates of the Staphylococcus intermedius group (SIG), including 111 Staphylococcus pseudintermediusand 4 Staphylococcus delphini isolates, 37 of which were mecA positive. The disk and MIC breakpoints evaluated included the Clinical and Laboratory Standards Institute (CLSI) M100-S25 Staphylococcus aureus/Staphylococcus lugdunensis oxacillin MIC breakpoints and cefoxitin disk and MIC breakpoints, the CLSI M100-S25 coagulase-negative Staphylococcus (CoNS) oxacillin MIC breakpoint and cefoxitin disk breakpoint, the CLSI VET01-S2 S. pseudintermedius oxacillin MIC and disk breakpoints, and the European Committee on Antimicrobial Susceptibility Testing (EUCAST) S. pseudintermedius cefoxitin disk breakpoint. The oxacillin results interpreted by the VET01-S2 (disk and MIC) and M100-S25 CoNS (MIC) breakpoints agreed with the results of mecA/mecC PCR for all isolates, with the exception of one false-resistant result (1.3% of mecA/mecC PCR-negative isolates). In contrast, cefoxitin tests performed poorly, ranging from 3 to 89% false susceptibility (very major errors) and 0 to 48% false resistance (major errors). BD Phoenix, bioMérieux Vitek 2, and Beckman Coulter MicroScan commercial automated susceptibility test panel oxacillin MIC results were also evaluated and demonstrated >95% categorical agreement with mecA/mecC PCR results if interpreted by using the M100-S25 CoNS breakpoint. The Alere penicillin-binding protein 2a test accurately detected all

  17. Consumer Decision-Making Based on Review Websites: Are There Differences Between Choosing a Hotel and Choosing a Physician?

    Science.gov (United States)

    Germeni, Evi; Schulz, Peter J

    2016-01-01

    Background Web users are increasingly encouraged to rate and review consumer services (eg, hotels, restaurants) and, more recently, this is also the case for physicians and medical services. The resemblance in the setup and design of commercial rating websites (CRWs) and Web-based physician rating websites (PRWs) raises the question of whether choice-making processes based on the two types of websites could also be similar. Objective This qualitative study sought to explore the extent to which consumer decision making based on Web-based reviews is the same for consumer services (ie, choice of a hotel) and health services (ie, choice of a pediatrician), while providing an in-depth understanding of potential differences or similarities. Methods Between June and August 2015, we carried out a total of 22 qualitative interviews with young parents residing in the German-speaking part of Switzerland. Participants were invited to complete 2 choice tasks, which involved (1) choosing a hotel based on the commercial Web-based rating website TripAdvisor and (2) selecting a pediatrician based on the PRW Jameda. To better understand consumers’ thought processes, we instructed participants to “think aloud”, namely to verbalize their thinking while sorting through information and reaching decisions. Using a semistructured interview guide, we subsequently posed open-ended questions to allow them to elaborate more on factors influencing their decision making, level of confidence in their final choice, and perceived differences and similarities in their search for a hotel and a physician. All interviews were recorded, transcribed, and analyzed using an inductive thematic approach. Results Participants spent on average 9:57 minutes (standard deviation=9:22, minimum=3:46, maximum=22:25) searching for a hotel and 6:17 minutes (standard deviation=4:47, minimum=00:38, maximum=19:25) searching for a pediatrician. Although the choice of a pediatrician was perceived as more important

  18. Mic Power? Connections and the hip hop nation in Kampala, Uganda

    DEFF Research Database (Denmark)

    Schneidermann, Nanna

    2014-01-01

    Hip hop culture has been celebrated in the media and scholarship as a universal youth language, part of a global hip hop nation, and a type of counter-public. This article examines the everyday meanings and practices of hip hop among hip hop activists in Kampala, Uganda, specifically within...... the Batuuze rap group. Rather than portraying hip hop as a counter-public of the disempowered, I argue that the Batuuze engagement is based on what I call moral economy that enables the negotiation of connections in social and cultural networks towards what is considered a good life. Here, the hip hop nation...... is less of an alternative public sphere and more a way of articulating and contextualizing the world in a specific locality, which produces connections and opportunities in the young rappers’ lives....

  19. Mastite micótica em ruminantes causada por leveduras Mycotic mastitis in ruminants caused by yeasts

    Directory of Open Access Journals (Sweden)

    Andréia Spanamberg

    2009-02-01

    Full Text Available A ocorrência de casos esporádicos de mastite causados por microrganismos de origem ambiental pode ser considerada como emergente e as leveduras, os fungos leveduriformes e os filamentosos são alguns dos principais agentes envolvidos. Em relação à mastite micótica, as leveduras são freqüentemente causas de infecções da glândula mamária em animais produtores de leite. A maior parte dos casos ocorre sob a forma de surtos localizados e/ou após tratamento com antimicrobianos. Os principais gêneros envolvidos são Candida e Cryptococcus, além de outros como Geotrichum, Pichia e Trichosporon. O objetivo do trabalho é revisar os aspectos gerais sobre a mastite micótica causada por leveduras e fungos leveduriformes, tais como etiologia, causas predisponentes, patogenicidade, diagnóstico, tratamento e profilaxia por meio de uma abordagem cronológica dos primeiros relatos, mas com enfoque principal nos resultados descritos recentemente na literatura veterinária nacional e internacional. O controle da mastite micótica é fundamentado em métodos preventivos, como adequado manejo da ordenha, correta higienização dos equipamentos e das instalações, com a finalidade de reduzir o número de animais acometidos, além de garantir a qualidade e a inocuidade dos produtos lácteos.The veterinary literature registers sporadic cases of infections caused by environmental microorganisms in which the main agents involved are yeasts, yeasts-like and filamentous fungi. In relation to dairy animals, the yeasts are more frequently incriminated as the aetiological agents of mycotic mastitis. Most cases occur under the form of localized outbreaks and / or after treatment with antimicrobial agents. The main genera involved in mastitis are Candida and Cryptococcus, besides others such as Geotrichum, Pichia and Trichosporon. The purpose of this review is to point out the main aspects of mastitis caused by yeasts and yeast-like fungi, such as etiology

  20. ¿Deben estar los cómics en las bibliotecas?

    OpenAIRE

    Artacho Orihuela, Concepción María

    2002-01-01

    It is unquestionable that the comic book as an artistic and literary expression occupies a specific place in this century’s popular culture. An attempt will be made to give an overview of comic books and their inclusion in information services. This paper presents by way of example the pioneering project in Spain of the creation of the Comic Library of the Murcia Regional Library. This centre was born with the aim of including comic books as part of information services and as far as possible...

  1. Experimental approaches to identify small RNAs and their diverse roles in bacteria--what we have learnt in one decade of MicA research.

    Science.gov (United States)

    Van Puyvelde, Sandra; Vanderleyden, Jozef; De Keersmaecker, Sigrid C J

    2015-10-01

    Nowadays the identification of small RNAs (sRNAs) and characterization of their role within regulatory networks takes a prominent place in deciphering complex bacterial phenotypes. Compared to the study of other components of bacterial cells, this is a relatively new but fast-growing research field. Although reports on new sRNAs appear regularly, some sRNAs are already subject of research for a longer time. One of such sRNAs is MicA, a sRNA best described for its role in outer membrane remodeling, but probably having a much broader function than anticipated. An overview of what we have learnt from MicA led to the conclusion that even for this well-described sRNA, we still do not have the overall picture. More general, the story of MicA might become an experimental lead for unraveling the many sRNAs with unknown functions. In this review, three important topics in the sRNA field are covered, exemplified from the perspective of MicA: (i) identification of new sRNAs, (ii) target identification and unraveling the biological function, (iii) structural analysis. The complex mechanisms of action of MicA deliver some original insights in the sRNA field which includes the existence of dimer formation or simultaneous cis and trans regulation, and might further inspire the understanding of the function of other sRNAs.

  2. Mathematical model for the growth of P. aeruginosa and four mutator strains in sub-MIC concentration of Ciprofloxacin

    DEFF Research Database (Denmark)

    Philipsen, Kirsten Riber; Christiansen, Lasse Engbo; Madsen, Henrik;

    growing under sub-MIC Ciprofloxacin concentration (0.1 μg/ml), in order to describe the growth pattern under the presence of antibiotic. Data available for the modelling process is bioscreen measurements of the bacterial content as a function of time for each bacteria strain growing in LB media...... parameters are estimated from data using a Maximum Likelihood approach. We introduce a new expression for multiple substrate dependent growth in LB media, which is identified by a method first introducing the growth as a random walk in the model. From the bioscreen measurement we found a change in the growth...... pattern under the presence of Ciprofloxacin. In most cases the presence of Ciprofloxacin resulted in a longer lag phase, a period of growth followed by a transition phase and then a second period of growth. We have developed a new mathematical model using a multi substrate approach, which will be able...

  3. La rentabilidad del cómic en la enseñanza de la cultura en E/LE

    Directory of Open Access Journals (Sweden)

    Jaume Brines Gandía

    2012-01-01

    Full Text Available El presente trabajo trata sobre el uso del cómic como recurso didáctico en la clase de E/LE para enseñar cultura. Aunque la cultura en la clase de E/LE muchas veces pasa desapercibida, constituye un excelente instrumento para la enseñanza de la lengua extranjera y, sobre todo, para que el futuro aprendiente sepa cómo, cuándo y de qué modo usar la lengua. Antes de desarrollar la presente experiencia práctica, es necesario que tratemos el término cultura y las distintas acepciones que supone.

  4. El aprendizaje del lenguaje visual en 6º de Primaria a través del cómic

    OpenAIRE

    Domínguez-Fernández, Elvira

    2014-01-01

    El estilo de vida actual, basado en el estímulo visual, demanda un mayor énfasis en la educación de los estudiantes de Primaria para la lectura de imágenes, con el objetivo de formar sujetos con juicio crítico y habilidad para la interpretación y creación de mensajes visuales. Para alcanzar tal objetivo, el siguiente documento propone la introducción del cómic en el aula de 6º curso de Educación Primaria como recurso didáctico para la adquisición y mejora de los códigos comunicativos a nivel ...

  5. Analysis Of Economic Motivation When Individuals Choose An Educational Path

    Directory of Open Access Journals (Sweden)

    Viktor Anatolyevich Koksharov

    2015-03-01

    Full Text Available The authors consider the economic motivations when individuals choose an educational path. This line of research is relevant from both, the point of view of science — research of economic behavior of an individual, and the point of view of practice — allows to increase efficiency of investments in a human capital. The authors have developed the economic and mathematical model of choice of optimum educational paths by individuals. The model is realized in the software and approved on real data on more than 5,5 thousand students. For the analysis of the importance of rational economic expectations when an educational path has to be chosen, the paths chosen by students is compared and the educational paths optimum from the point of view of economic rationality are calculated. The analysis of the results has showed that mainly, the choice of educational paths happens according to the economic motivations. On the considered selection, 66 % of prospective students have chosen an optimum path from the point of view of economic preferences. The most significant factor providing development of optimum educational paths is an expectation of higher income upon completion of education — 22 % of all educational paths, and a possibility of cost-cutting of educating or state-subsidized education — 12 %. In our opinion, one of the most important practical results of the research of optimum educational path is the need to consider expectations of students and prospective student when developing a state policy of investment in human capital.

  6. Matrix Model for Choosing Green Marketing Sustainable Strategic Alternatives

    Directory of Open Access Journals (Sweden)

    Cătălina Sitnikov

    2015-08-01

    Full Text Available Green marketing examines the symbiotic role played by marketing in ensuring sustainable business, exploring issues concerning the environment and the way strategic decisions can influence it. At present, the environmental issues concern more and more the competitive approach any organization can implement. Based on this approach, organizations can gain competitive advantage by managing environmental variables and by developing and implementing green marketing strategies. Considering the importance and impact of green marketing, by using theoretical concepts and defining a set of research directions, the paper and the research conducted were focused on creating a matrix model for choosing the optimal green marketing strategy, oriented towards competitive advantage. The model is based on the correlation that can be established among the generic strategies of competitive advantage, the variables of extended marketing mix (7Ps and the green marketing strategy matrix. There are also analyzed the implications that may be generated within a company by the adoption of a green marketing strategy and its role in promoting the environmental benefits of products.

  7. Time to choose – DSM-5, ICD-11 or both?

    Directory of Open Access Journals (Sweden)

    Tyrer, Peter

    2014-09-01

    Full Text Available DSM-5 was published in May 2013, and ICD 11 is not due to be published until the end of 2015 at the earliest. Nevertheless, it is possible to make a comparison at this early stage as much of the main decisions have been made with both classifications. DSM-5 aimed to make a paradigm shift by providing objective, independent measures of classification, but in this respect it clearly failed. It did respond to previous criticisms that there were too many diagnoses in the classification and that eliminated some conditions in favour of larger groupings (eg, autism spectrum disorder, but it has still come in for heavy criticism. ICD 11 deviates from DSM-5 in radically different classifications of personality and stress disorders and in general has pursued a different pathway, concentrating on clinical utility as the main guide to the classification. It is up to practitioners to choose which they prefer, but ICD 11 will be in a much stronger position than ICD 10 was when it was published in 1999.

  8. Tissue regeneration during tissue expansion and choosing an expander

    Directory of Open Access Journals (Sweden)

    K Agrawal

    2012-01-01

    Full Text Available This paper reviews the various aspects of tissue regeneration during the process of tissue expansion. "Creep" and mechanical and biological "stretch" are responsible for expansion. During expansion, the epidermis thickens, the dermis thins out, vascularity improves, significant angiogenesis occurs, hair telogen phase becomes shorter and the peripheral nerves, vessels and muscle fibres lengthen. Expansion is associated with molecular changes in the tissue. Almost all these biological changes are reversible after the removal of the expander.This study is also aimed at reviewing the difficulty in deciding the volume and dimension of the expander for a defect. Basic mathematical formulae and the computer programmes for calculating the dimension of tissue expanders, although available in the literature, are not popular. A user-friendly computer programme based on the easily available Microsoft Excel spread sheet has been introduced. When we feed the area of defect and base dimension of the donor area or tissue expander, this programme calculates the volume and height of the expander. The shape of the expander is decided clinically based on the availability of the donor area and the designing of the future tissue movement. Today, tissue expansion is better understood biologically and mechanically. Clinical judgement remains indispensable in choosing the size and shape of the tissue expander.

  9. Choosing early pregnancy termination methods in Urban Mozambique.

    Science.gov (United States)

    Mitchell, Ellen M H; Kwizera, Amata; Usta, Momade; Gebreselassie, Hailemichael

    2010-07-01

    Little is known about who chooses medication abortion with misoprostol and why. Women seeking early abortion in 5 public hospitals in Maputo, Mozambique were recruited in 2005 and 2006 to explore decision-making strategies, method preferences and experiences with misoprostol and vacuum aspiration for early abortion. Client screenings (n=1799), structured clinical surveys (n=837), in-depth exit interviews (n=70), and nurse focus groups (n=2) were conducted. Triangulation of qualitative and quantitative data revealed seemingly contradictory findings. Choice of method reflected women's heightened concerns about privacy, pain, quality of home support, HIV infection risk, sexuality, and safety of research participation. Urban Mozambican women are highly motivated to find early pregnancy termination techniques that they deem socially and clinically low-risk. Although 42% found vaginal misoprostol self-administration challenging and 25% delayed care for over a week to amass funds for user fees, almost all (96%) reported adequate preparation and comfort with home management. Women reported satisfaction with all methods and quality of care, even if the initial method failed or pain management or postabortion contraception were not offered. A more nuanced understanding of what women value most can yield service delivery models that are responsive and effective in reducing maternal death and disability from unsafe abortion. PMID:20452107

  10. When I cut, you choose method implies intransitivity

    Science.gov (United States)

    Makowski, Marcin; Piotrowski, Edward W.

    2014-12-01

    There is a common belief that humans and many animals follow transitive inference (choosing A over C on the basis of knowing that A is better than B and B is better than C). Transitivity seems to be the essence of rational choice. We present a theoretical model of a repeated game in which the players make a choice between three goods (e.g. food). The rules of the game refer to the simple procedure of fair division among two players, known as the “I cut, you choose” mechanism which has been widely discussed in the literature. In this game one of the players has to make intransitive choices in order to achieve the optimal result (for him/her and his/her co-player). The point is that an intransitive choice can be rational. Previously, an increase in the significance of intransitive strategies was achieved by referring to models of quantum games. We show that relevant intransitive strategies also appear in the classic description of decision algorithms.

  11. Choosing Markovian Credit Migration Matrices by Nonlinear Optimization

    Directory of Open Access Journals (Sweden)

    Maximilian Hughes

    2016-08-01

    Full Text Available Transition matrices, containing credit risk information in the form of ratings based on discrete observations, are published annually by rating agencies. A substantial issue arises, as for higher rating classes practically no defaults are observed yielding default probabilities of zero. This does not always reflect reality. To circumvent this shortcoming, estimation techniques in continuous-time can be applied. However, raw default data may not be available at all or not in the desired granularity, leaving the practitioner to rely on given one-year transition matrices. Then, it becomes necessary to transform the one-year transition matrix to a generator matrix. This is known as the embedding problem and can be formulated as a nonlinear optimization problem, minimizing the distance between the exponential of a potential generator matrix and the annual transition matrix. So far, in credit risk-related literature, solving this problem directly has been avoided, but approximations have been preferred instead. In this paper, we show that this problem can be solved numerically with sufficient accuracy, thus rendering approximations unnecessary. Our direct approach via nonlinear optimization allows one to consider further credit risk-relevant constraints. We demonstrate that it is thus possible to choose a proper generator matrix with additional structural properties.

  12. Application of the Vertex Exchange Method to estimate a semi-parametric mixture model for the MIC density of Escherichia coli isolates tested for susceptibility against ampicillin.

    Science.gov (United States)

    Jaspers, Stijn; Verbeke, Geert; Böhning, Dankmar; Aerts, Marc

    2016-01-01

    In the last decades, considerable attention has been paid to the collection of antimicrobial resistance data, with the aim of monitoring non-wild-type isolates. This monitoring is performed based on minimum inhibition concentration (MIC) values, which are collected through dilution experiments. We present a semi-parametric mixture model to estimate the entire MIC density on the continuous scale. The parametric first component is extended with a non-parametric second component and a new back-fitting algorithm, based on the Vertex Exchange Method, is proposed. Our data example shows how to estimate the MIC density for Escherichia coli tested for ampicillin and how to use this estimate for model-based classification. A simulation study was performed, showing the promising behavior of the new method, both in terms of density estimation as well as classification.

  13. The effects of microstructure on MIC susceptibility in high strength aluminum alloys

    Energy Technology Data Exchange (ETDEWEB)

    Walsh, D.W. [California Polytechnic State Univ., San Luis Obispo, CA (United States). Materials Engineering Dept.

    1999-11-01

    Aluminum alloys, and in particular Al-Li-Cu alloys are attractive to the aerospace industry. The high specific strength and stiffness of these alloys will improve lift efficiency, fuel economy, performance and increase payload capabilities of air and spacecraft. The objectives of this work were to examine the corrosion behavior of Al 2195 (UNS A92195) (Al-4Cu-1Li) and to assess the effect of welding on corrosion behavior in biologically active and in sterile waters. Al 2219 (UNS A922 19) samples were used in parallel tests to provide a baseline for the data generated. In this study samples were exposed to mild corrosive water solutions in both the as received and as welded conditions. The results of the study indicate exposure to biologically active solutions increases the corrosion rate. In addition, welding increases the corrosion rate in both Al 2195 and Al 2219, and causes severe localization in Al 2195. Furthermore, autogenously welded Al 2195 samples were more susceptible to attack than heterogeneously welded Al 2195 samples. Heterogeneously welded samples in both materials also had high corrosion rates, but only the Al 2195 material was subject to localization of attack. The partially melted zones of Al 2195 samples were subject to severe, focused attack. In Al 2219, interdendritic constituents in welded areas and intergranular constituents in base material were cathodic to the Al rich matrix materials. In Al 2195, some interdendritic constituents in welded areas and intergranular constituents in base material were anodic to the Al rich matrix materials. Corrosion resistance was correlated to material microstructure using optical microscopy, scanning electron microscopy, electron probe microanalysis and polarization resistance.

  14. Multi-Criteria Decision Making Based in Choosing an Appropriate Tractor

    OpenAIRE

    M.B. Lak; A.M Borghaee

    2016-01-01

    Agricultural mechanization goal is to maximize the utility. Establishment of subsidies systemization and Iran incorporation with World Target Organization (WTO), choosing an appropriate technology will be more important. Agricultural development is due to correct mechanization and choosing an appropriate tractor is one of mechanization implementation bases. In the paper, criteria involved in choosing an appropriate tractor were considered according to Hamedan province conditions and the best ...

  15. Wild-Type and Non-Wild-Type Mycobacterium tuberculosis MIC Distributions for the Novel Fluoroquinolone Antofloxacin Compared with Those for Ofloxacin, Levofloxacin, and Moxifloxacin.

    Science.gov (United States)

    Yu, Xia; Wang, Guirong; Chen, Suting; Wei, Guomei; Shang, Yuanyuan; Dong, Lingling; Schön, Thomas; Moradigaravand, Danesh; Parkhill, Julian; Peacock, Sharon J; Köser, Claudio U; Huang, Hairong

    2016-09-01

    Antofloxacin (AFX) is a novel fluoroquinolone that has been approved in China for the treatment of infections caused by a variety of bacterial species. We investigated whether it could be repurposed for the treatment of tuberculosis by studying its in vitro activity. We determined the wild-type and non-wild-type MIC ranges for AFX as well as ofloxacin (OFX), levofloxacin (LFX), and moxifloxacin (MFX), using the microplate alamarBlue assay, of 126 clinical Mycobacterium tuberculosis strains from Beijing, China, of which 48 were OFX resistant on the basis of drug susceptibility testing on Löwenstein-Jensen medium. The MIC distributions were correlated with mutations in the quinolone resistance-determining regions of gyrA (Rv0006) and gyrB (Rv0005). Pharmacokinetic/pharmacodynamic (PK/PD) data for AFX were retrieved from the literature. AFX showed lower MIC levels than OFX but higher MIC levels than LFX and MFX on the basis of the tentative epidemiological cutoff values (ECOFFs) determined in this study. All strains with non-wild-type MICs for AFX harbored known resistance mutations that also resulted in non-wild-type MICs for LFX and MFX. Moreover, our data suggested that the current critical concentration of OFX for Löwenstein-Jensen medium that was recently revised by the World Health Organization might be too high, resulting in the misclassification of phenotypically non-wild-type strains with known resistance mutations as wild type. On the basis of our exploratory PK/PD calculations, the current dose of AFX is unlikely to be optimal for the treatment of tuberculosis, but higher doses could be effective. PMID:27324769

  16. Choosing preclinical study models of diabetic retinopathy: key problems for consideration

    Directory of Open Access Journals (Sweden)

    Mi XS

    2014-11-01

    Full Text Available Xue-Song Mi,1,2 Ti-Fei Yuan,3,4 Yong Ding,1 Jing-Xiang Zhong,1 Kwok-Fai So4,5 1Department of Ophthalmology, First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, People’s Republic of China; 2Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, People’s Republic of China; 3School of Psychology, Nanjing Normal University, Nanjing, People’s Republic of China; 4Department of Ophthalmology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong; 5Guangdong-Hongkong-Macau Institute of Central Nervous System, Jinan University, Guangzhou, People’s Republic of China Abstract: Diabetic retinopathy (DR is the most common complication of diabetes mellitus in the eye. Although the clinical treatment for DR has already developed to a relative high level, there are still many urgent problems that need to be investigated in clinical and basic science. Currently, many in vivo animal models and in vitro culture systems have been applied to solve these problems. Many approaches have also been used to establish different DR models. However, till now, there has not been a single study model that can clearly and exactly mimic the developmental process of the human DR. Choosing the suitable model is important, not only for achieving our research goals smoothly, but also, to better match with different experimental proposals in the study. In this review, key problems for consideration in choosing study models of DR are discussed. These problems relate to clinical relevance, different approaches for establishing models, and choice of different species of animals as well as of the specific in vitro culture systems. Attending to these considerations will deepen the understanding on current study models and optimize the experimental design for the final goal of preventing DR. Keywords: animal model, in vitro culture, ex vivo culture, neurovascular dysfunction

  17. Energy-Efficient and Comfortable Buildings through Multivariate Integrated Control (ECoMIC)

    Energy Technology Data Exchange (ETDEWEB)

    Birru, Dagnachew [Philips Electronics North America Corporation, Andover, MA (United States); Wen, Yao-Jung [Philips Electronics North America Corporation, Andover, MA (United States); Rubinstein, Francis M. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Clear, Robert D. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2013-10-28

    developed control technology were evaluated and verified through both simulations and testbed implementations. Simulations coupling a DOE medium office reference building in EnergyPlus building simulation software and a prototype controller in Matlab were performed. During summer time in a mixed-humid climate zone, the simulations revealed reductions of 27% and 42% in electric lighting load and cooling load, respectively, when compared to an advanced base case with daylight dimming and blinds automatically tilted to block direct sun. Two single-room testbeds were established. The testbed at Philips Lighting business building (Rosemont, IL) was designed for quantifying energy performance of integrated controls. This particular implementation achieved 40% and 79% savings on lighting and HVAC energy, respectively, compared to a relatively simple base case operated on predefined schedules. While the resulting energy savings was very encouraging, it should be noted that there may be several caveats associated with it. 1) The test was run during late spring and early summer, and the savings numbers might not be directly used to extrapolate the annual energy savings. 2) Due to the needs for separate control and metering of the small-scale demonstrator within a large building, the HVAC system, hence the corresponding savings, did not represent a typical energy code-compliant design. 3) The light level in the control case was regulated at a particular setpoint, which was lower than then the full-on light level in the base case, and the savings resulted from tuning down the light level to the setpoint was not attributable to the contribution of the developed technology. The testbed at the Lawrence Berkeley National Laboratory (Berkeley, CA) specifically focused on glare control integration, and has demonstrated the feasibility and capability of the glare detection and prevention technique. While the short one-month test in this testbed provided a functional indication of the

  18. 携带兔斯氏艾美耳球虫MIC-5基因减毒鼠伤寒沙门菌活疫苗的安全性、稳定性与免疫原性%Safety, stability and immunogenicity of attenuated Salmonella typhimurium carrying MIC-5 gene of Eimeria stieda

    Institute of Scientific and Technical Information of China (English)

    孟庆玲; 乔军; 才学鹏; 闫鸿斌; 田广孚; 骆学农

    2011-01-01

    对携带兔斯氏艾美耳球虫微线蛋白-5基因(MIC-5)真核表达质粒asd-pBMIC-5-IL-15的减毒鼠伤寒沙门菌X4550(X4550/asd-pBMIC-5-IL-15)进行了安全性、稳定性与免疫原性试验.结果显示,重组菌在109CFU剂量以下对家兔安全;连续培养30代重组菌,重组表达质粒可稳定存在于X4550内,具有良好的遗传稳定性;用重组菌2次免疫动物后,既能诱导机体产生抗兔斯氏艾美耳球虫抗体,也能显著增强淋巴细胞增殖水平,抗球虫指数为164.4.试验表明,减毒沙门菌介导的兔球虫调节型DNA疫苗具有良好的安全性、稳定性和免疫原性.%The security,stability and immunogenicity trials of recombinant Salmonella typhimurium X4550 carrying rabbit's Eimeria stiedai MIC-5 gene expression plasmid asd-pBMIC-5-IL-15 (X4550/asd-pBMIO5-IL-15) was assayed in this study. The results showed that the 109 CFU inoculation dose was safe in the experimental rabbits. The recombinant plasmid existed stably in X4550 after 30 passages, which displayed a good genetic stability. After two immunizations in rabbits, the recombinant Salmonella typhimurium induced the specific antibodies against rabbit Eimeria stiedai and significantly improved the level of lymphocyte proliferation. The anti-coccidia index reached 164. 4. The results indicated that the regulation DNA vaccine mediated by Salmonella had a good security,stability and immunogenicity against rabbit Eimeria stiedai.

  19. Energy-Efficient and Comfortable Buildings through Multivariate Integrated Control (ECoMIC)

    Energy Technology Data Exchange (ETDEWEB)

    Birru, Dagnachew [Philips Electronics North America Corporation, Andover, MA (United States); Wen, Yao-Jung [Philips Electronics North America Corporation, Andover, MA (United States); Rubinstein, Francis M. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Clear, Robert D. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2013-10-28

    developed control technology were evaluated and verified through both simulations and testbed implementations. Simulations coupling a DOE medium office reference building in EnergyPlus building simulation software and a prototype controller in Matlab were performed. During summer time in a mixed-humid climate zone, the simulations revealed reductions of 27% and 42% in electric lighting load and cooling load, respectively, when compared to an advanced base case with daylight dimming and blinds automatically tilted to block direct sun. Two single-room testbeds were established. The testbed at Philips Lighting business building (Rosemont, IL) was designed for quantifying energy performance of integrated controls. This particular implementation achieved 40% and 79% savings on lighting and HVAC energy, respectively, compared to a relatively simple base case operated on predefined schedules. While the resulting energy savings was very encouraging, it should be noted that there may be several caveats associated with it. 1) The test was run during late spring and early summer, and the savings numbers might not be directly used to extrapolate the annual energy savings. 2) Due to the needs for separate control and metering of the small-scale demonstrator within a large building, the HVAC system, hence the corresponding savings, did not represent a typical energy code-compliant design. 3) The light level in the control case was regulated at a particular setpoint, which was lower than then the full-on light level in the base case, and the savings resulted from tuning down the light level to the setpoint was not attributable to the contribution of the developed technology. The testbed at the Lawrence Berkeley National Laboratory (Berkeley, CA) specifically focused on glare control integration, and has demonstrated the feasibility and capability of the glare detection and prevention technique. While the short one-month test in this testbed provided a functional indication of the

  20. Spectrophotometric Determination of Microamounts of Uranium previous Extraction with TBP-MIC; Determinacion Espectrofotometrica de Microcantidades de Uranio previa extraccin con Metilisobutilcetona-Fosfato de Tributilo

    Energy Technology Data Exchange (ETDEWEB)

    Vera Palomino, J.; Palomares Delgado, F.; Petrement, J.; Fernandez Cellini, R.

    1962-07-01

    Selective extraction of uranium in nitric acid medium with a mixture of Tbp-MIC (1:10) has been achieved. Aluminium nitrate was used as salting agent. Complexing agents were added in order to avoid extraction of impurities. Extraction conditions have been studied so that extraction is almost practically complete in a single run. (Author) 19 refs.

  1. XML In Vitro Comparison of MIC Crude Extracts of Active Actinomycetes Isolated with Terbinafine, Griseofulvin Ketoconazole and Fluconazole against Microsporum Canis, Microsporum Gypseum and Trichophyton Mentagrophytes

    Directory of Open Access Journals (Sweden)

    Keikha, N. (MSc

    2015-05-01

    Full Text Available Background and Objective: Dermatophytes are the fungi that have the ability to attack the keratinized tissues such as the skin, hair and nails. Infections caused by these organisms are named dermatophytosis. We aimed to compare Minimum inhibitory concentration (MIC of Crude extracts of Active Actinomycete Isolates with Terbinafine, Griseofulvin, Ketoconazole and Fluconazole Drugs against Microsporum Canis, Microsporum gypseum and Trichophyton mentagrophytes. Material and Methods: In this experimental study, in order to find MIC by actionmycete, 100 isolates were studied and then crude extracts of the active actinomycete isolates were prepared in sterile conditions. Finally, the crude extracts obtained at different concentrations were used to obtain the MIC of Microsporum Canis, Microsporum gypseum and Trichophyton mentagrophytes. Moreover, various concentrations of the drugs such as terbinafine, griseofulvin, ketoconazole and fluconazole in solvent Dimethyl sulfoxide (DMSO were prepared and their growth inhibitory effect was evaluated and then compared with the results obtained from the crude extract of active actinomycete isolates. Results: the crude extracts obtained from active Actioiomycetes isolates and the drugs such as terbinafine, griseofulvin, ketoconazole and fluconazole, in a dose-dependent manner, could inhibit the growth of Microsporum Canis, Microsporum gypseum and Trichophyton Mentagrophytes. Conclusion: compared to MIC of Crude extract of active actinomycete isolates, Terbinafine has a significant effect on the growth inhibition in all of the fungal Dermatophytes and then griseofulvin, ketoconazole and fluconazole are in the next rank, respectively.

  2. Un acercamiento didáctico a la primera mitad del s. XX a través de los cómics

    OpenAIRE

    Becerra Romero, Daniel; Jorge Godoy, Soraya

    2014-01-01

    El cómic ha sido un recurso didáctico que, aunque conocido, se ha utilizado poco en el mundo de la enseñanza, sobre todo si tenemos en cuenta sus posibilidades. En el presente artículo nos hemos planteado un acercamiento a la Historia Contemporánea

  3. El cómic en la enseñanza del español como lengua extranjera

    Directory of Open Access Journals (Sweden)

    Jorge Catalá Carrasco

    2007-01-01

    Full Text Available La experiencia práctica que voy a relatar pretende mostrar las posibilidades que el cómic tiene, como producto cultural, dentro de las clases de español para extranjeros. Mi relación con las clases de español como lengua extranjera (E/LE se ciñe a estudiantes universitarios de un nivel avanzado, esto es, aquellos que han cursado las clases básicas de gramática y quieren profundizar en la lengua y la cultura hispánicas. Dentro de este marco es donde encuadro la presente experiencia. Los estudiantes con los que he trabajado provienen, en su mayoría, de The University of Georgia en los EE.UU. y cursan un semestre en Valencia (España para perfeccionar el idioma. Mi relación profesional con esta universidad norteamericana data de hace más de 4 años, primero como profesor asistente de español en los EE.UU. y luego como coordinador y profesor dentro del programa académico UGA en España, en Valencia.

  4. La intertextualidad en el cine de Álex de la Iglesia:El caso del cómic

    Directory of Open Access Journals (Sweden)

    Neftalí Pérez Franco

    2010-10-01

    Full Text Available Este artículo repasa la influencia del tebeo en las películas del director vasco, Alex de la Iglesia, cuyas primeras obras artísticas se deben a su condición de joven autor de historietas. El cine de este cineasta está marcado por claras reminiscencias provenientes de las viñetas: los superhéroes patéticos de Acción mutante se mueven por un contexto futurista muy del cómic de ciencia ficción; el humor estereotipado y los personajes grotescos del tebeo de la editorial Bruguera inundan todas sus comedias; o también son destacables los diversos homenajes narrativos o estéticos a la escuela franco-belga de Hergé y Goscinny. Esta fuerte influencia recorre toda su filmografía desde la mencionada ópera prima Acción mutante, hasta Crimen Ferpecto, pasando por títulos como El día de la bestia, Perdita Durango, Muertos de risa o La comunidad, hasta convertirse en un autor abanderado del fenómeno freak que marca tendencia en el cine español.

  5. Determination of MIC distribution of arbekacin, cefminox, fosfomycin, biapenem and other antibiotics against gram-negative clinical isolates in South India: a prospective study.

    Directory of Open Access Journals (Sweden)

    Sangeetha Rajenderan

    Full Text Available To determine the in vitro activity of antibiotics, including arbekacin, cefminox, fosfomycin and biapenem which are all still unavailable in India, against Gram-negative clinical isolates.We prospectively collected and tested all consecutive isolates of Escherichia coli, Klebsiella spp., Pseudomonas aeruginosa and Acinetobacter spp. from blood, urine and sputum samples between March and November 2012. The minimum inhibition concentration (MIC of 16 antibiotics was determined by the broth micro-dilution method.Overall 925 isolates were included; 211 E. coli, 207 Klebsiella spp., 153 P. aeruginosa, and 354 Acinetobacter spp. The MIC50 and MIC90 were high for cefminox, biapenem and arbekacin for all pathogens but interpretative criteria were not available. The MIC50 was categorized as susceptible for a couple of antibiotics, including piperacillin/tazobactam, carbapenems and amikacin, for E. coli, Klebsiella spp. and P. aeruginosa. However, for Acinetobacter spp., the MIC50 was categorized as susceptible only for colistin. On the other hand, fosfomycin was the only antibiotic that inhibited 90% of E. coli and Klebsiella spp. isolates, while 90% of P. aeruginosa isolates were inhibited only by colistin. Finally, 90% of Acinetobacter spp. isolates were not inhibited by any antibiotic tested.Fosfomycin and colistin might be promising antibiotics for the treatment of infections due to E. coli or Klebsiella spp. and P. aeruginosa, respectively, in India; however, clinical trials should first corroborate the in vitro findings. The activity of tigecycline should be evaluated, as this is commonly used as last-resort option for the treatment of multidrug-resistant Acinetobacter infections.

  6. Induction of human papilloma virus E6/E7-specific cytotoxic T-lymphocyte activity in immune-tolerant, E6/E7-transgenic mic

    NARCIS (Netherlands)

    Riezebos-Brilman, A; Regts, J; Freyschmidt, EJ; Dontje, B; Wilschut, J; Daemen, T

    2005-01-01

    Despite promising preclinical results of various therapeutic anticancer immunization strategies, these approaches may not be effective enough to eradicate tumors in cancer patients. While most animal models are based on fast-growing transplantable tumors, malignancies in, for example, cervical cance

  7. Plasma MIC-1 and PAPP-a levels are decreased among women presenting to an early pregnancy assessment unit, have fetal viability confirmed but later miscarry.

    Directory of Open Access Journals (Sweden)

    Tu'uhevaha J Kaitu'u-Lino

    Full Text Available BACKGROUND: We have recently shown first trimester Macrophage inhibitory cytokine-1 (MIC-1 and Pregnancy Associated Plasma Protein-A (PAPP-A serum concentrations are depressed among asymptomatic women destined to miscarry. Here we examined whether plasma levels of MIC-1 and PAPP-A are depressed among women presenting to an Early Pregnancy Assessment Unit (EPAU, noted to have a confirmed viable fetus, but subsequently miscarry. METHODS: We performed a prospective cohort study, recruiting 462 women in the first trimester presenting to EPAU and had fetal viability confirmed by ultrasound. We obtained plasma samples on the same day and measured MIC-1, PAPP-A and human chorionic gonadotrophin (hCG, grouping the cohort according to whether they later miscarried or not. To correct for changes in analyte levels across gestation, we expressed the data as Multiples of the normal Median (MoMs. RESULTS: We recruited 462 participants presenting to EPAU at 5-12 weeks gestation. Most (80% presented with symptoms of threatened miscarriage (e.g. abdominal pain, vaginal bleeding. 34 (7.4% subsequently miscarried. Median plasma MIC-1 levels among those who miscarried were 50% of those with ongoing pregnancies (Miscarriage cohort MoM 0.50 (25(th-75(th centiles: 0.29-1.33 vs ongoing pregnancies MoM 1.00 (0.65-1.38; p=0.0025. Median plasma PAPP-A MoMs among those who miscarried was 0.57 (0.00-1.12, significantly lower than those with ongoing pregnancies (MoMs 1.00 (0.59-1.59; p=0.036. Plasma hCG levels were also significantly depressed among those who miscarried compared to those with ongoing pregnancies. However, the performance of MIC-1 as a diagnostic marker to predict miscarriage in this cohort was modest, and not improved with the addition of hCG. CONCLUSION: MIC-1 and PAPP-A levels are significantly depressed in women presenting to EPAU with ultrasound evidence of fetal viability, but later miscarry. While they are unlikely to be useful as predictive biomarkers

  8. Choosing Beauty and Feeling Good: How Attractive Product Design Increases Self-Affirmation

    Directory of Open Access Journals (Sweden)

    Townsend Claudia

    2015-11-01

    Full Text Available Consumers construct and maintain self-concepts through the use of branded consumer products. Yet product choice not only reflects an actual or desired image of the self but can also directly influence a person’s sense of self and even boost self-esteem. The aesthetics of a product is an attribute that has the power to transform how consumers perceive themselves. The mere act of choosing a beautiful product over a less good-looking one affirms people’s sense of self - who they are and what their values are. It goes beyond personal image building and self-presentation; its impact is also turned inwards. Choice of high design works as a unique form of affirmation. It works unconsciously, and high design may even be a particularly powerful form of affirmation precisely because its relationship to the self and one’s values is not obvious. And design is more powerful than other features in this respect. Comfort and ease of use, taste and brand do not have the same self-affirming quality as design. It is not simply that “treating” oneself or going for the pleasurable option has an affirming effect; it is specific to the choice of aesthetics.

  9. Choosing a sustainable demolition waste management strategy using multicriteria decision analysis.

    Science.gov (United States)

    Roussat, Nicolas; Dujet, Christiane; Méhu, Jacques

    2009-01-01

    This paper presents an application of the ELECTRE III decision-aid method in the context of choosing a sustainable demolition waste management strategy for a case study in the city of Lyon, France. This choice of waste management strategy takes into consideration the sustainable development objectives, i.e. economic aspects, environmental consequences, and social issues. Nine alternatives for demolition waste management were compared with the aid of eight criteria, taking into account energy consumption, depletion of abiotic resources, global warming, dispersion of dangerous substances in the environment, economic activity, employment, and quality of life of the local population. The case study concerned the demolition of 25 buildings of an old military camp. Each alternative was illustrated with different waste treatments, such as material recovery, recycling, landfilling, and energy recovery. The recommended solution for sustainable demolition waste management for the case study is a selective deconstruction of each building with local material recovery in road engineering of inert wastes, local energy recovery of wood wastes, and specific treatments for hazardous wastes. PMID:18572397

  10. Genetic Diversity and mRNA Expression of Porcine MHC Class I Chain-Related 2 (SLA-MIC2) Gene and Development of a High-Resolution Typing Method.

    Science.gov (United States)

    Dadi, Hailu; Le, MinhThong; Dinka, Hunduma; Nguyen, DinhTruong; Choi, Hojun; Cho, Hyesun; Choi, Minkyeung; Kim, Jin-Hoi; Park, Jin-Ki; Soundrarajan, Nagasundarapandian; Park, Chankyu

    2015-01-01

    The genetic structure and function of MHC class I chain-related (MIC) genes in the pig genome have not been well characterized, and show discordance in available data. Therefore, we have experimentally characterized the exon-intron structure and functional copy expression pattern of the pig MIC gene, SLA-MIC2. We have also studied the genetic diversity of SLA-MIC2 from seven different breeds using a high-resolution genomic sequence-based typing (GSBT) method. Our results showed that the SLA-MIC2 gene has a similar molecular organization as the human and cattle orthologs, and is expressed in only a few tissues including the small intestine, lung, and heart. A total of fifteen SLA-MIC2 alleles were identified from typing 145 animals, ten of which were previously unreported. Our analysis showed that the previously reported and tentatively named SLA-MIC2*05, 07, and 01 alleles occurred most frequently. The observed heterozygosity varied from 0.26 to 0.73 among breeds. The number of alleles of the SLA-MIC2 gene in pigs is somewhat lower compared to the number of alleles of the porcine MHC class I and II genes; however, the level of heterozygosity was similar. Our results indicate the comprehensiveness of using genomic DNA-based typing for the systemic study of the SLA-MIC2 gene. The method developed for this study, as well as the detailed information that was obtained, could serve as fundamental tools for understanding the influence of the SLA-MIC2 gene on porcine immune responses.

  11. Causes and Consequences of Choosing Different Assurance Providers: An International Study of Sustainability Reporting

    NARCIS (Netherlands)

    P.M. Perego (Paolo)

    2009-01-01

    textabstractAn increasing number of companies voluntary disclose information about their social and environment performance in sustainability reports. This study investigates the causes and consequences of choosing different assurance providers for companies seeking independent verification of their

  12. Choosing goals, not rules: deciding among rule-based action plans.

    Science.gov (United States)

    Klaes, Christian; Westendorff, Stephanie; Chakrabarti, Shubhodeep; Gail, Alexander

    2011-05-12

    In natural situations, movements are often directed toward locations different from that of the evoking sensory stimulus. Movement goals must then be inferred from the sensory cue based on rules. When there is uncertainty about the rule that applies for a given cue, planning a movement involves both choosing the relevant rule and computing the movement goal based on that rule. Under these conditions, it is not clear whether primates compute multiple movement goals based on all possible rules before choosing an action, or whether they first choose a rule and then only represent the movement goal associated with that rule. Supporting the former hypothesis, we show that neurons in the frontoparietal reach areas of monkeys simultaneously represent two different rule-based movement goals, which are biased by the monkeys' choice preferences. Apparently, primates choose between multiple behavioral options by weighing against each other the movement goals associated with each option.

  13. Choosing a Primary Health Care Provider (PCP): A Guide for Young Women

    Science.gov (United States)

    ... Gynecology Medical Conditions Nutrition & Fitness Emotional Health Choosing a Primary Health Care Provider (PCP): General Information Posted ... taking care of yourself. Why do I need a PCP? You need a PCP so that your ...

  14. Choosing a Primary Health Care Provider (PCP): A Guide for Young Men

    Science.gov (United States)

    ... Health Medical Conditions Nutrition & Fitness Emotional Health Choosing a Primary Health Care Provider (PCP): General Information Posted ... help address your problems. Why do I need a PCP? You need a PCP so that your ...

  15. Nuevo Orden Mundial. Narraciones sobre el poder y superhéroes en el cómic mainstream estadounidense de Stormwatch a Black Summer (1996-2008)

    OpenAIRE

    Hernández Cano, Eduardo

    2009-01-01

    Los cómics de superhéroes han sido estudiados por la crítica, sobre todo, como artefactos mitológicos de implicaciones morales y filosóficas. Pero desde finales de los noventa una parte importante del cómic de superhéroes mainstream se ha convertido en una narrativa simbólica sobre el poder en el mundo contemporáneo, alimentándose del discurso y los acontecimientos políticos, textualizando de manera sutil, política y moralmente provocadora, acontecimientos reales como el nuevo terrorismo y la...

  16. An investigation of microbial diversity in crude oil & seawater injection systems and microbiologically influenced corrosion (MIC) of linepipe steels under different exposure conditions

    Science.gov (United States)

    AlAbbas, Faisal Mohammed

    During oil and gas operations, pipeline networks are subjected to different corrosion deterioration mechanisms that result from the interaction between the fluid process and the linepipe steel. Among these mechanisms is microbiologically influenced corrosion (MIC) that results from accelerated deterioration caused by different indigenous microorganisms that naturally reside in the hydrocarbon and associated seawater injection systems. The focus of this research is to obtain comprehensive understanding of MIC. This work has explored the most essential elements (identifications, implications and mitigations) required to fully understand MIC. Advanced molecular-based techniques, including sequencing of 16S rRNA genes via 454 pyrosequencing methodologies, were deployed to provide in-depth understanding of the microbial diversity associated with crude oil and seawater injection systems and their relevant impact on MIC. Key microbes including sulfate reducing bacteria (SRB) and iron reducing bacteria (IRB) were cultivated from sour oil well field samples. The microbes' phylotypes were identified in the laboratory to gain more thorough understanding of how they impact microbial corrosion. Electrochemical and advanced surface analytical techniques were used for corrosion evaluations of linepipe carbon steels (API 5L X52 and X80) under different exposure conditions. On the identification front, 454 pyrosequencing of both 16S rRNA genes indicated that the microbial communities in the corrosion products obtained from the sour oil pipeline, sweet crude pipeline and seawater pipeline were dominated by bacteria, though archaeal sequences (predominately Methanobacteriaceae and Methanomicrobiaceae) were also identified in the sweet and sour crude oil samples, respectively. The dominant bacterial phylotypes in the sour crude sample included members of the Thermoanaerobacterales, Synergistales, and Syntrophobacterales. In the sweet crude sample, the dominant phylotypes included

  17. Disidencia sexual en el cómic alemán contemporáneo: el caso de Ralf König

    OpenAIRE

    Saxe, Facundo

    2016-01-01

    Este trabajo aborda la representación de la sexualidad disidente en el cómic alemán contemporáneo. Se analiza la obra del autor alemán Ralf König desde una perspectiva propia de los estudios queer y la disidencia de sexo-género. A través de un recorrido crítico se conceptualiza la figura del autor en su campo cultural y su proyección vinculada a las sexualidades disidentes en Europa y a la tradición del cómic en Alemania. Como caso paradigmático se realiza un análisis textual d...

  18. Determination of MIC distribution and epidemiological cutoff values for bedaquiline and delamanid in Mycobacterium tuberculosis using the MGIT 960 system equipped with TB eXiST.

    Science.gov (United States)

    Keller, Peter M; Hömke, Rico; Ritter, Claudia; Valsesia, Giorgia; Bloemberg, Guido V; Böttger, Erik C

    2015-07-01

    Bedaquiline (Sirturo) and delamanid (Deltyba) have recently been approved by the regulatory authorities for treatment of multidrug-resistant tuberculosis (MDR-TB). Antimicrobial susceptibility testing is not established for either substance. On the basis of the use of the MGIT 960 system equipped with EpiCenter/TB eXiST, we determined a mean bedaquiline MIC for wild-type strains of 0.65 mg/liter (median, 0.4 mg/liter) and an epidemiological cutoff (ECOFF) of 1.6 mg/liter; for delamanid, a mean wild-type drug MIC of 0.013 mg/liter (median, 0.01 mg/liter) and an ECOFF of 0.04 mg/liter were determined. PMID:25941226

  19. Sex determination in blue mussels: Which method to choose?

    Science.gov (United States)

    Fraser, Marc; Fortier, Marlène; Roumier, Pierre-Hervé; Parent, Lise; Brousseau, Pauline; Fournier, Michel; Surette, Céline; Vaillancourt, Cathy

    2016-09-01

    Sexing methods of blue mussels are mostly based on the presence or absence of gametes, and do not take into account reproductive cycle stages. Exposure effects can be affected by the sex of mussels, thus the aim of this study is to determine an efficient sex determination protocol taking into account the reproductive cycle stage. Eight mussel sexing methods were compared. This study demonstrates that the first step in discerning sex in blue mussels should be assessing the reproductive stage, which can be done by mantle histology. During gametogenesis, histology allows the differentiation of males from females by the observation of gametes. However, when mussels are in sexual rest, the only method that should be used is the sex-specific gene method. PMID:27448778

  20. Choosing a language in international office service encounters

    DEFF Research Database (Denmark)

    Hazel, Spencer

    Preisler (eds.) Language alternation, language choice and language encounter in international education. Dordrecht: Springer Preisler, Bent, Ida Klitgård, and Anne H. Fabricius. (2011). Language and learning in the international university: from English uniformity to diversity and hybridity. Bristol...... at an International Office help desk, situated at a Danish university. Here, staff and student cohorts are made up of both local and ‘international’ members, with the help desk service providing support for both incoming and outgoing students participating in study exchange programmes such as ERASMUS. Specifically......, this paper demonstrates a number of practices through which culturally and linguistically diverse members are able to settle upon a language for conducting these service encounters (which in this case is usually Danish or English). I show how the opening sequences have a built-in mechanism for avoiding...

  1. Why do different people choose different university degrees? Motivation and the choice of degree

    OpenAIRE

    Anya eSkatova; Eamonn eFerguson

    2014-01-01

    Different people choose which undergraduate degree to study at the university for different reasons. To date, there have been limited attempts to identify individual differences in motivation that drive the undergraduate degree choice. We identified that people choose university degrees for four reasons: career concerns (Career), intrinsic interest (Interest) in the subject, an opportunity to help others (Helping) and because they are looking for an easy option into higher education (Loafing)...

  2. Why do different people choose different university degrees? Motivation and the choice of degree

    OpenAIRE

    Skatova, Anya; Ferguson, Eamonn

    2014-01-01

    Different people choose undergraduate degrees to study at university for different reasons. To date, there have been limited attempts to identify individual differences in motivation that drive undergraduate degree choice. We identified that people choose university degrees for four reasons: career concerns (Career), intrinsic interest in the subject (Interest), an opportunity to help others (Helping) and because they are looking for an easy option to get into higher education (Loafing). We i...

  3. Study of Model of Grey Decision Making to Choose Leading Industry of Cities

    Institute of Scientific and Technical Information of China (English)

    JinglongZhang; GuangyongChen; WeiGuo; GangXie

    2004-01-01

    The Leading industry influences the economic development of one city. This paper establishes a decision factor system of choosing leading industry of cities, applies related decision theory in Grey System and invents the procedure of choosing leading industry, which achieved a good practical effect. Afterwards, the city Tianmen acclaims the dress industry as Leading Industry in its "The Tenth Five-Year Plan for Economic and Social Development of City TianMen".

  4. Mentor Graphics推出MicReD工业化的1500A功率循环测试设备

    Institute of Scientific and Technical Information of China (English)

    2014-01-01

    日前,Mentor Graphics公司宣布推出全新MicReD Industrial Power Tester1500A(工业化的1500A功率循环测试设备),用于电力电子器件的功率循环测试和热特性测试,以模拟和测量电力电子器件寿命期内的表现。

  5. Correlation between Ratio of Serum Doxycycline Concentration to MIC and Rapid Decline of Antibody Levels during Treatment of Q Fever Endocarditis

    OpenAIRE

    Rolain, Jean-Marc; Boulos, Areen; Mallet, Marie-Noëlle; Raoult, Didier

    2005-01-01

    Endocarditis is the major clinical manifestation of chronic Q fever. Although doxycycline along with hydroxychloroquine remains the mainstay of medical therapy for Q fever endocarditis, there are wide variations in the rapidity of the patient's decline of antibody levels during such therapy. We undertook a retrospective examination of whether there was any correlation between the ratio of serum concentration to MIC of doxycycline and response to treatment in patients with Q fever endocarditis...

  6. Flares on dMe stars: IUE and optical observations of At Mic, and comparison of far-ultraviolet stellar and solar flares

    International Nuclear Information System (INIS)

    The paper concerns observations of a large flare event on the dMe star At Mic, detected by the International Ultraviolet Explorer. The far-ultraviolet spectra of the flare is compared with those of other stellar flares, and also with a large solar flare recorded by the Skylab mission in 1973. The quiescent-phase optical and ultraviolet spectrum of the same dMe flare star is discussed. (U.K.)

  7. Assessing the Accuracy of High Resolution Digital Surface Models Computed by PhotoScan® and MicMac® in Sub-Optimal Survey Conditions

    Directory of Open Access Journals (Sweden)

    Marion Jaud

    2016-06-01

    Full Text Available For monitoring purposes and in the context of geomorphological research, Unmanned Aerial Vehicles (UAV appear to be a promising solution to provide multi-temporal Digital Surface Models (DSMs and orthophotographs. There are a variety of photogrammetric software tools available for UAV-based data. The objective of this study is to investigate the level of accuracy that can be achieved using two of these software tools: Agisoft PhotoScan® Pro and an open-source alternative, IGN© MicMac®, in sub-optimal survey conditions (rugged terrain, with a large variety of morphological features covering a range of roughness sizes, poor GPS reception. A set of UAV images has been taken by a hexacopter drone above the Rivière des Remparts, a river on Reunion Island. This site was chosen for its challenging survey conditions: the topography of the study area (i involved constraints on the flight plan; (ii implied errors on some GPS measurements; (iii prevented an optimal distribution of the Ground Control Points (GCPs and; (iv was very complex to reconstruct. Several image processing tests are performed with different scenarios in order to analyze the sensitivity of each software package to different parameters (image quality, numbers of GCPs, etc.. When computing the horizontal and vertical errors within a control region on a set of ground reference targets, both methods provide rather similar results. A precision up to 3–4 cm is achievable with these software packages. The DSM quality is also assessed over the entire study area comparing PhotoScan DSM and MicMac DSM with a Terrestrial Laser Scanner (TLS point cloud. PhotoScan and MicMac DSM are also compared at the scale of particular features. Both software packages provide satisfying results: PhotoScan is more straightforward to use but its source code is not open; MicMac is recommended for experimented users as it is more flexible.

  8. Phased array ultrasonic technology (PAUT) contribution to detection and sizing of microbially influenced corrosion (MIC) of service water systems and shutdown coolers heat exchangers in OPG CANDU stations

    International Nuclear Information System (INIS)

    Three PAUT techniques [linear scan - longitudinal waves, sector scan -longitudinal waves and sector scan-transverse waves] were developed and validated to assess the MIC attack in service water systems (SWS) and shutdown coolers heat-exchangers (SDC-HX) of Darlington and Pickering CANDU stations. PAUT employs linear array probes with a frequency between 4-12 MHz, depending on surface conditions, component geometry and MIC size/category to be detected. Examples from lab validation and field trials are presented. Based on field trials results, the techniques were optimized and new cal blocks were manufactured. It was demonstrated for mid-length pipes and for SDC-HX, the PAUT is the best technique compared with D-meter conventional UT and with guided waves. The expected field accuracy is about 0.5 mm (0.020) for large MIC attack. The ligament evaluation is technically achievable for colonies / pin holes located 2 mm under the outer surface. Improvements were identified and implemented for the next outages. (author)

  9. Doppler imaging an X-ray flare on the ultrafast rotator BO Mic - A contemporaneous multiwavelength study using XMM-Newton and VLT

    CERN Document Server

    Wolter, U; Schmitt, J H M M; Ness, J U

    2007-01-01

    We present an analysis of contemporaneous photospheric, chromospheric and coronal structures on the highly active K-dwarf star BO Mic (Speedy Mic). We localize a moderate flare in the stellar atmosphere and study its energetics, size and thermal behaviour. The analysis is based on strictly simultaneous X-ray, UV- and optical observations carried out by XMM-Newton and the VLT. We use Doppler imaging and related methods for the localization of features. Based on X-ray spectroscopy we study the the coronal plasma in and outside the flare. The flare emits in X-rays and UV, but is not detected in white light; it is located at intermediate latitude between an extended spot group and the weakly spotted pole. We estimate its height below 0.4 stellar radii making it clearly distinct in longitude and height from the prominences found about two stellar radii above the surface. While BO Mic's photospheric brightness is modulated due to extended starspots, neither the chromospheric nor the X-ray emission show a pronounced...

  10. New recombinant chimeric antigens, P35-MAG1, MIC1-ROP1, and MAG1-ROP1, for the serodiagnosis of human toxoplasmosis.

    Science.gov (United States)

    Drapała, Dorota; Holec-Gąsior, Lucyna; Kur, Józef

    2015-05-01

    The aim of the study was to evaluate the usefulness of 3 chimeric Toxoplasma gondii antigens, P35-MAG1, MIC1-ROP1 and MAG1-ROP1, in the serodiagnosis of an acute toxoplasmosis in humans. Proteins were produced as fusion proteins containing His tags ends and then further purified by metal affinity chromatography. Their application for the diagnosis of recently acquired T. gondii infection was tested in IgG and IgM enzyme-linked immunosorbent assays (ELISAs). At 100%, 77.3%, and 86.4%, respectively, the reactivity of the IgG ELISA using P35-MAG1, MIC1-ROP1, and MAG1-ROP1 for sera from patients where acute toxoplasmosis was suspected was significantly higher than for the samples from people with a chronic infection, at 26.2%, 36.1%, and 32.8%, respectively. Moreover, P35-MAG1, MIC1-ROP1, and MAG1-ROP1 detected IgM antibodies with a reactivity at 81.8%, 72.7%, and 59.1%, respectively. The results presented in the article show that, particularly, P35-MAG1 may be useful in the preliminary detection of recent T. gondii infection.

  11. Chulos y novios en viñetas. Cómo dedicarse al cómic (gay y no morir en el intento

    Directory of Open Access Journals (Sweden)

    Sebas Martín (autor de cómics

    2009-01-01

    Full Text Available Vivir del cómic es, de por sí, un imposible, pero las dificultades se acrecientan si el objetivo de un autor es dedicarse al cómic gay. En este artículo de cariz autobiográfico, se relatan los obstáculos y los éxitos que han marcado la trayectoria profesional de su autor, desde sus inicios, en los años 80, como creador de un fanzine, hasta la proliferación de proyectos que marcan los 2000. Con todo, se traza un recorrido por el panorama cultural e ideológico de la España de las últimas décadas, a través del cual asistimos a la lenta pero constante superación de los prejuicios que aún hoy rodean tanto el género del cómic como el mundo gay.

  12. Phased array ultrasonic technology (PAUT) contribution to detection and sizing of microbially influenced corrosion (MIC) of service water systems and shutdown coolers heat exchangers in OPG CANDU stations

    Energy Technology Data Exchange (ETDEWEB)

    Ciorau, P.; Pullia, L.; Hazelton, T., E-mail: peter.ciorau@opg.com, E-mail: lou.pullia@opg.com, E-mail: trek.hazelton@opg.com [Ontario Power Generation, Toronto, Ontario (Canada); Daks, W. [CAD WIRE, Markham, Ontario (Canada)

    2008-07-01

    Three PAUT techniques [linear scan - longitudinal waves, sector scan -longitudinal waves and sector scan-transverse waves] were developed and validated to assess the MIC attack in service water systems (SWS) and shutdown coolers heat-exchangers (SDC-HX) of Darlington and Pickering CANDU stations. PAUT employs linear array probes with a frequency between 4-12 MHz, depending on surface conditions, component geometry and MIC size/category to be detected. Examples from lab validation and field trials are presented. Based on field trials results, the techniques were optimized and new cal blocks were manufactured. It was demonstrated for mid-length pipes and for SDC-HX, the PAUT is the best technique compared with D-meter conventional UT and with guided waves. The expected field accuracy is about 0.5 mm (0.020{sup )} for large MIC attack. The ligament evaluation is technically achievable for colonies / pin holes located 2 mm under the outer surface. Improvements were identified and implemented for the next outages. (author)

  13. Therapeutic assessment with an adolescent: choosing connections over substances.

    Science.gov (United States)

    Austin, Cynthia A; Krumholz, Lauren S; Tharinger, Deborah J

    2012-01-01

    This case study provides an in-depth example of a comprehensive therapeutic assessment with an adolescent (TA-A) and his parents. The TA-A addressed parental concerns about their son's drug experimentation as well as the adolescent's own private questions about his distinctiveness from others, all set against a backdrop of ongoing parental conflict and poor communication. The TA-A process and how it is specifically tailored to balance the needs of adolescents and their parents is discussed. Subsequently, each step of TA-A is illustrated through the case study. Research findings at the conclusion of the assessment and at follow-up indicated significant decreases in internalizing symptomology and school problems, increases in self-esteem and self-reliance, and improved family functioning as reported by the adolescent. At follow-up, the father spoke of developing a more assertive parenting approach and successful follow-through on recommendations. This case study provides a template for clinicians interested in conducting TA-A. PMID:22475356

  14. Laboratory automation in clinical bacteriology: what system to choose?

    Science.gov (United States)

    Croxatto, A; Prod'hom, G; Faverjon, F; Rochais, Y; Greub, G

    2016-03-01

    Automation was introduced many years ago in several diagnostic disciplines such as chemistry, haematology and molecular biology. The first laboratory automation system for clinical bacteriology was released in 2006, and it rapidly proved its value by increasing productivity, allowing a continuous increase in sample volumes despite limited budgets and personnel shortages. Today, two major manufacturers, BD Kiestra and Copan, are commercializing partial or complete laboratory automation systems for bacteriology. The laboratory automation systems are rapidly evolving to provide improved hardware and software solutions to optimize laboratory efficiency. However, the complex parameters of the laboratory and automation systems must be considered to determine the best system for each given laboratory. We address several topics on laboratory automation that may help clinical bacteriologists to understand the particularities and operative modalities of the different systems. We present (a) a comparison of the engineering and technical features of the various elements composing the two different automated systems currently available, (b) the system workflows of partial and complete laboratory automation, which define the basis for laboratory reorganization required to optimize system efficiency, (c) the concept of digital imaging and telebacteriology, (d) the connectivity of laboratory automation to the laboratory information system, (e) the general advantages and disadvantages as well as the expected impacts provided by laboratory automation and (f) the laboratory data required to conduct a workflow assessment to determine the best configuration of an automated system for the laboratory activities and specificities. PMID:26806135

  15. Intermediate hepatocellular carcinoma: How to choose thebest treatment modality?

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    Intermediate stage, or stage B according to BarcelonaClinic Liver Cancer classification, of hepatocellularcarcinoma (HCC) comprises a heterogeneous populationwith different tumor burden and liver function. Thisheterogeneity is confirmed by the large variability oftreatment choice and disease-relate survival. The aimof this review was to highlight the existing evidencesregarding this specific topic. In a multidisciplinaryevaluation, patients with large (〉 5 cm) solitary HCC should be firstly considered for liver resection (LR).When LR is unfeasible, locoregional treatments areevaluable therapeutic options, being transarterialchemoembolization (TACE), the most used procedure.Percutaneous ablation can be an evaluable treatmentfor large HCC. However, the efficacy of all ablativeprocedures decrease as tumor size increases over 3 cm.In clinical practice, a combination treatment strategy[TACE or transarterial radioembolization (TARE)-plus percutaneous ablation] is "a priori" preferredin a relevant percentage of these patients. On theother hands, sorafenib is the treatment of choice inpatients who are unsuitable to surgery and/or witha contraindication to locoregional treatments. Inmultifocal HCC, TACE is the first-line treatment. Therole of TARE is still undefined. Surgery may have alsoa role in the treatment of multifocal HCC in selectedcases (patients with up to three nodules, multifocalHCC involving 2-3 adjacent liver segments). In somepatients with bilobar disease the combination of LR andablative treatment may be a valuable option. The choiceof the best treatment in the patient with intermediatestage HCC should be "patient-tailored" and made by amultidisciplinary team.

  16. Intermediate hepatocellular carcinoma: How to choose the best treatment modality?

    Science.gov (United States)

    Di Costanzo, Giovan Giuseppe; Tortora, Raffaella

    2015-05-28

    Intermediate stage, or stage B according to Barcelona Clinic Liver Cancer classification, of hepatocellular carcinoma (HCC) comprises a heterogeneous population with different tumor burden and liver function. This heterogeneity is confirmed by the large variability of treatment choice and disease-relate survival. The aim of this review was to highlight the existing evidences regarding this specific topic. In a multidisciplinary evaluation, patients with large (> 5 cm) solitary HCC should be firstly considered for liver resection (LR). When LR is unfeasible, locoregional treatments are evaluable therapeutic options, being transarterial chemoembolization (TACE), the most used procedure. Percutaneous ablation can be an evaluable treatment for large HCC. However, the efficacy of all ablative procedures decrease as tumor size increases over 3 cm. In clinical practice, a combination treatment strategy [TACE or transarterial radioembolization (TARE)-plus percutaneous ablation] is "a priori" preferred in a relevant percentage of these patients. On the other hands, sorafenib is the treatment of choice in patients who are unsuitable to surgery and/or with a contraindication to locoregional treatments. In multifocal HCC, TACE is the first-line treatment. The role of TARE is still undefined. Surgery may have also a role in the treatment of multifocal HCC in selected cases (patients with up to three nodules, multifocal HCC involving 2-3 adjacent liver segments). In some patients with bilobar disease the combination of LR and ablative treatment may be a valuable option. The choice of the best treatment in the patient with intermediate stage HCC should be "patient-tailored" and made by a multidisciplinary team.

  17. Cyberbullying: Should Schools choose between Safety and Privacy?

    Directory of Open Access Journals (Sweden)

    Michael Laubscher

    2015-12-01

    Full Text Available In this theoretical article, we explore the tangled messiness of the application of human rights versus the 21st-century monster called "cyberbullying" in schools and focus on some of the challenges schools face daily. The research will reveal that cyberbullying victims were almost twice as likely to attempt suicide as youth who had not experienced cyberbullying, which implies that this is a phenomenon schools ought not to take lightly. We argue that everyone has a right to the freedom of expression, including in cyberspace, and begin by exploring how legal principles evolved in an attempt to deal with the limitations placed on an individual's right to freedom of expression. As we are about to reveal, though, matters become even more complicated when this freedom of expression relates to cyberspace, a space where users might have an expectation of privacy and even enjoy a state of anonymity. Clearly, the right to privacy and the right to freedom of expression need to be balanced and respected should school authorities be called upon to identify and discipline a cyberbully. This balancing act is one that needs to be investigated and carefully expounded upon, and is an issue that has not yet been sufficiently addressed in South Africa. Seeing that countries such as the United States of America and Canada have attempted to deal with this issue, it would be prudent to discuss the strides these countries have made, the challenges they have faced, and the insights they have gained, in an attempt to alert South Africa to the complex issues cyberbullying could raise. Working from this premise, this article will focus on the right to privacy, specifically in relation to Bill C-13 recently passed in Canada and the resultant Canadian Supreme Court decision in the case R v Spencer, a case that shed further light on the issue of privacy in cyberspace. We conclude the discussion by highlighting several potential pitfalls legislation such as Bill C-13 could

  18. mics : investigación de conceptos y de términos paleontológicos, y uso como recurso didáctico en la Educación Primaria

    OpenAIRE

    Gonçalves, Rosilene; Machado, Deusana Maria

    2005-01-01

    Este trabajo investiga el modo en que los cómics, como recurso didáctico, tratan los contenidos paleontológicos. Tras un sistemático análisis, resultó evidente que esos conceptos están presentes en los cómics con aciertos pero también con muchos errores y equivocaciones, que no pueden ser ignorados. Los maestros deberían estar atentos a los cómics y usarlos en su práctica educativa.

  19. Morphological and sedimentological evidences of repeated avulsions of Someşu Mic River (Romania), associated to salt tectonics

    Science.gov (United States)

    Persoiu, I.; Radoane, M.

    2009-04-01

    Over the last decades, the Holocene evolution of the rivers became an important topic for the scientific community. Whereas most of these studies emphasized the role of climate in the rivers' evolution, little attention has been paid to tectonics, especially at small scale. Here we present a model of Holocene river evolution from the Transylvanian Basin (Romania), where salt tectonics plays an important role. Someşul Mic River (105 km long, 20 mc/s) is located in the NW part of the Transylvanian Basin, Romania. It has a dranage basin of 3773 km2 and the catchment's area is located in the Apuseni Mountains. The river has a well-developed floodplain, with a length of 75 km (calculated along its axis) and an average width of 2 km. In the upper sector, the river flows on red clays, sandstones and limestone of Eocene and Oligocene age (disposed in monoclinal strata), while in the lower sector, the bedrock consists of marls and volcanic tuffs of Miocene age, affected by diapiric alignments. The sedimentary structure of the floodplain is simple, with coarse Lateglacial gravels at the bottom and more fine Holocene sediments (pebble, sand, clay and silt) in its upper part; but some deviations from this general model, attributed to active tectonics, are observed along the river (e.g., absence of the coarser complex, variable proportion of the two complexes, etc). The main characteristic of the river is the high degree of alternation of channel types, from sinuous, meandering and even braided, to anabranched reaches. In order to decipher which mechanism is responsible for the development of the floodplain, we have analyzed in detail a section of the river, using a combination of high-resolution topographic surveys, electrical imaging, core drilling and granulometric analyses. In the investigated area, the river flows on Miocene marls partly covered by sediments, having a sinuous reach, with 2-3 m high banks. To the east, a diapiric syncline stretches parallel to the valley

  20. An investigation of microbial diversity in crude oil & seawater injection systems and microbiologically influenced corrosion (MIC) of linepipe steels under different exposure conditions

    Science.gov (United States)

    AlAbbas, Faisal Mohammed

    During oil and gas operations, pipeline networks are subjected to different corrosion deterioration mechanisms that result from the interaction between the fluid process and the linepipe steel. Among these mechanisms is microbiologically influenced corrosion (MIC) that results from accelerated deterioration caused by different indigenous microorganisms that naturally reside in the hydrocarbon and associated seawater injection systems. The focus of this research is to obtain comprehensive understanding of MIC. This work has explored the most essential elements (identifications, implications and mitigations) required to fully understand MIC. Advanced molecular-based techniques, including sequencing of 16S rRNA genes via 454 pyrosequencing methodologies, were deployed to provide in-depth understanding of the microbial diversity associated with crude oil and seawater injection systems and their relevant impact on MIC. Key microbes including sulfate reducing bacteria (SRB) and iron reducing bacteria (IRB) were cultivated from sour oil well field samples. The microbes' phylotypes were identified in the laboratory to gain more thorough understanding of how they impact microbial corrosion. Electrochemical and advanced surface analytical techniques were used for corrosion evaluations of linepipe carbon steels (API 5L X52 and X80) under different exposure conditions. On the identification front, 454 pyrosequencing of both 16S rRNA genes indicated that the microbial communities in the corrosion products obtained from the sour oil pipeline, sweet crude pipeline and seawater pipeline were dominated by bacteria, though archaeal sequences (predominately Methanobacteriaceae and Methanomicrobiaceae) were also identified in the sweet and sour crude oil samples, respectively. The dominant bacterial phylotypes in the sour crude sample included members of the Thermoanaerobacterales, Synergistales, and Syntrophobacterales. In the sweet crude sample, the dominant phylotypes included

  1. A few philosophical ruminations on the human condition and choosing to live well

    Directory of Open Access Journals (Sweden)

    Blake E. Hestir

    2008-06-01

    Full Text Available The notion that life is meaningful through choosing to live well has historically received substantive attention in various philosophical circles, notably the ancient Greek philosophers Socrates, Plato, and Aristotle, and more recently several of the existentialists. In some respects, the idea of choosing to live well is a “thematization” of two widely-recognized, independent components of a meaningful life: happiness and authenticity. I develop this notion of choosing to live well by exploring, developing, and relating these conceptions of happiness and authenticity. By appealing to a very basic account of human nature that has found favor among a great number of people, I show how happiness and authenticity complement each other as conditions for the possibility of living meaningfully.

  2. Using the hydrophobic subtraction model to choose orthogonal columns for online comprehensive two-dimensional liquid chromatography

    DEFF Research Database (Denmark)

    Græsbøll, Rune; Nielsen, Nikoline Juul; Christensen, Jan H.

    2014-01-01

    A method for choosing orthogonal columns for a specific sample set in on-line comprehensive two-dimensional liquid chromatography (LC×LC) was developed on the basis of the hydrophobic subtraction model. The method takes into account the properties of the sample analytes by estimating new F......-weights for the prediction of orthogonality. We compared sets of F-weights and used these F-weights to predict orthogonal column combinations: (1) the standard F-weights determined by Gilroy et al. [1], (2) F-weights determined from the retention of sample analytes, and the same procedure of calculation as described...... neutral and 4 acidic oxygenated polycyclic aromatic compounds (PACs) and 3 nitrogen-containing PAC bases was measured isocratically on 12 columns. The isocratic runs were used to determine the hydrophobic subtraction model analyte parameters, and these were used to estimate new F-weights and predict...

  3. Choosing the correct empirical antibiotic for urinary tract infection in pediatric: Surveillance of antimicrobial susceptibility pattern of Escherichia coli by E-Test method.

    Directory of Open Access Journals (Sweden)

    Iraj Sedighi

    2014-12-01

    Full Text Available Urinary Tract Infections (UTIs are of the most common bacterial diseases worldwide. We investigate the antibiotic susceptibility patterns of Escherichia coli (E. coli strains isolated from pediatric patients with community acquired urinary tract infection (UTI to find a clinical guidance for choosing a right empirical antibiotic in these patients.In this cross sectional study, 100 urine specimens which were positive for E. coli had been investigated for antibiotics susceptibility pattern. The susceptibility to Co-trimoxazol (25μg, Amikacin (30μg, Ceftriaxone (30μg, Nalidixic Acid (30μg, Cefixime (5μg, and Nitrofurantoin (300μg tested with Disk diffusion agar and MIC determined with the E-test.Mean age of patients was 38 Months. Girls had greater proportion than boys (74 versus 26%. In Disk diffusion method, 26% of the isolates were susceptible to cotrimoxazole. Susceptibility to amikacin, ceftriaxone, nitrofurantoin, nalidixic acid and cefixime was 94%, 66%, 97%, 62% and 52%, respectively. By E-Test method and according to CLSI criteria susceptibility for co-trimoxazol, amikacin, ceftriaxone and nalidixic acid was 37%, 97%, 67% and 50%, respectively. The highest percentage of agreement between Disk diffusion and E-Test method was found for amikacin (96% and the lowest percentage for co-trimoxazole (89%.Treatment failure, prolonged or repeated hospitalization, increased costs of care, and increased mortality are some consequence of bacterial resistance in UTIs. Misuse of antibiotics in each geographic location directly affects antibiotic resistance pattern. In the treatment of UTI, proper selection of antimicrobial agents should be relevant to the bacterial susceptibility testing surveillance. According to our results, amikacin as an injectable drug and nitrofurantoin as an oral agent could be used as a drug of choice in our region for children with UTIs.

  4. [Choosing contraception].

    Science.gov (United States)

    Gonzalez Velez, A C

    1998-06-01

    The development of contraception has allowed women to think about and experience motherhood not as their destiny but as an option. Humans have always been interested in controlling their fertility. Writings unearthed in the 18th century demonstrated the interest of the ancient Egyptians and Greeks in fertility control. The oral contraceptive (OC) pill, developed in the 1950s by Pincus and Rock, has allowed millions of women to avoid unwanted pregnancy. Since 1960, when the oral contraceptive Enovid was first marketed in the US, over 200 million women throughout the world have used OCs. Modern formulations have low hormone doses, which has minimized side effects. OCs now have an effectiveness of 98%. The method is controlled by the woman, permitting autonomous decisions about pregnancy. Currently, in Colombia, 12.9% of women in union use OCs, 25.7% are sterilized, 11.1% each use IUDs and traditional methods, 4.3% use condoms, 2.5% use injectables, 1.4% use vaginal tablets, 0.7% each use Norplant and vasectomy, and 1.8% use other methods. 27.8% use no method. OCs can be used as an emergency method in case of rape, an unexpected sexual encounter, or failure of another method. When used as a postcoital method, OCs must be taken within 72 hours of unprotected sexual intercourse.

  5. Choosing Independence

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Milo Djukanovic, Prime Minister of Montenegro, won a key referendum May 21 when voters in his tiny, mountainous nation endorsed a plan to split from Serbia and become an independent state. This marked a final step in the breakup of the former Yugoslavia formed by six republics.

  6. Choosing surgery

    DEFF Research Database (Denmark)

    Thorstensson, Carina; Lohmander, L; Frobell, Richard;

    2009-01-01

    ABSTRACT: BACKGROUND: The objective was to understand patients' views of treatment after acute anterior cruciate ligament (ACL) injury, and their reasons for deciding to request surgery despite consenting to participate in a randomised controlled trial (to 'cross-over'). METHODS: Thirty-four in...

  7. The Offer Framing Effect: Choosing Single versus Bundled Offerings Affects Variety Seeking

    OpenAIRE

    Mauricio Mittelman; Eduardo B. Andrade; Amitava Chattopadhyay; C. Miguel Brendl

    2014-01-01

    Choices of multiple items can be framed as a selection of single offerings (e.g., a choice of two individual candy bars) or of bundled offerings (e.g., a choice of a bundle of two candy bars). Four experiments provide strong evidence that consumers seek more variety when choosing from single than from bundled offerings. The offer framing effect shows that the mechanics of choosing--the ways consumers go about making choices of multiple items--affect variety seeking in a systematic manner. The...

  8. Importance of choosing a change of support model for global reserves estimation

    Energy Technology Data Exchange (ETDEWEB)

    Lantuejoul, C.

    1988-11-01

    The practical problem considered here is: how can block distribution in an ore body be forecast from sample data. The task is arduous because information yielded by samples is too often insufficient to allow an accurate evaluation of blocks. In practice, necessary additional information is obtained via a model. Choosing that model is crucial; the value of results reflects the model, i.e., its adequacy to represent reality. In this paper, the importance of choosing the change of support model is illustrated with simulations and practical examples (especially deposits with a skewed sample distribution and a large spike at the origin). An attempt to quantify this importance is made also.

  9. Determination of MIC Distribution and Epidemiological Cutoff Values for Bedaquiline and Delamanid in Mycobacterium tuberculosis Using the MGIT 960 System Equipped with TB eXiST

    OpenAIRE

    Peter M Keller; Hömke, Rico; Ritter, Claudia; Valsesia, Giorgia; Bloemberg, Guido V.; Böttger, Erik C.

    2015-01-01

    Bedaquiline (Sirturo) and delamanid (Deltyba) have recently been approved by the regulatory authorities for treatment of multidrug-resistant tuberculosis (MDR-TB). Antimicrobial susceptibility testing is not established for either substance. On the basis of the use of the MGIT 960 system equipped with EpiCenter/TB eXiST, we determined a mean bedaquiline MIC for wild-type strains of 0.65 mg/liter (median, 0.4 mg/liter) and an epidemiological cutoff (ECOFF) of 1.6 mg/liter; for delamanid, a mea...

  10. Metronidazole and clarithromycin resistance in Helicobacter pylori determined by measuring MICs of antimicrobial agents in color indicator egg yolk agar in a miniwell format. The Gastrointestinal Physiology Working Group of Universidad Peruana Cayetano Heredia and the Johns Hopkins University.

    Science.gov (United States)

    Vasquez, A; Valdez, Y; Gilman, R H; McDonald, J J; Westblom, T U; Berg, D; Mayta, H; Gutierrez, V

    1996-05-01

    Resistance of Helicobacter pylori to metronidazole often causes failure of commonly used combination drug treatment regimens. We determined the MICs of metronidazole and clarithromycin against 18 H. pylori strains from Peru using tetrazolium egg yolk (TEY) agar. The MIC results obtained by agar dilution with petri dishes were compared with the results found through a miniwell format. The results of the two protocols for measuring drug susceptibility differed by no more than 1 dilution in all cases. On TEY agar, bright-red H. pylori colonies were easy to identify against a yellow background. Sixty-one percent (11 of 18) of the strains were resistant to metronidazole (MIC, > or = 4 micrograms/ml) and 50% (9 of 18) were resistant to clarithromycin (MIC, > or = 0.125 micrograms/ml), whereas none (0 of 5) of the strains tested were resistant to tetracycline (MIC, > or = 1 micrograms/ml). Thus, the prevalence of metronidazole and clarithromycin resistance in Peru is higher than that in developed regions of the world. The miniwell plate with TEY agar allows easy H. pylori colony identification, requires about one-third less of the costly medium necessary for petri dish assaying, conserves space, and yields MICs equivalent to those with agar dilution in petri dishes.

  11. 微量MIC检测判断结核分枝杆菌药敏的方法学研究%Methodological research of MIC microtiter susceptibility testing for Mycobacterium tuberculosis

    Institute of Scientific and Technical Information of China (English)

    王洁; 陆俊梅; 黄晓辰; 丁元生; 胡忠义; 崔振玲

    2010-01-01

    .Results The best concentration of Mycobacterium tuberculosis in microwell is 10~(-3) mg/ml.The best results were read after 7-10 d The best cut-off value of drug susceptibility testing of isoniazid,streptomycin,rifampicin,ethambutol,ofloxacin,amikacin,capreomycin were 2μg/ml,0.25μg/ml,1 μg/ml,2μg/ml,1 μg/ml,4μg/ml and 4μg/ml,respectively,and the seusitivities were 93.5%,97.7%,93.5%,84.4%,95.8%,91.7% and 88.9% respectively,the specificities were 95.6%, 94.6%,100.0%,93.8%,92.9%,95.6% and 91.5% respectively.The accuracies were 95.0%,96.3%,97.5%,90.0%,93.8%,95.0% and 91.3%respectively.Conlusion The drug susceptibility testing method of microwell-MIC-test is accurate,rapid,low-cost and simple and worthy in application in tuberculosis hospital of resource limited countries like China.

  12. Assignment Choice: Do Students Choose Briefer Assignments or Finishing What They Started?

    Science.gov (United States)

    Hawthorn-Embree, Meredith L.; Skinner, Christopher H.; Parkhurst, John; O'Neil, Michael; Conley, Elisha

    2010-01-01

    Academic skill development requires engagement in effortful academic behaviors. Although students may be more likely to choose to engage in behaviors that require less effort, they also may be motivated to complete assignments that they have already begun. Seventh-grade students (N = 88) began a mathematics computation worksheet, but were stopped…

  13. Choosing a Hospital for Surgery: The Importance of Information on Quality of Care

    NARCIS (Netherlands)

    Dijs-Elsinga, J.; Otten, W.; Versluijs, M.; Smeets, H.J.; Kievit, J.; Vree, R.; Made, W.J. van der; Marang-Van De Mheen, P.J.

    2010-01-01

    OBJECTIVE: To assess whether patients use information on quality of care when choosing a hospital for surgery compared with more general hospital information. METHODS: In this cross-sectional study in 3 Dutch hospitals, questionnaires were sent to 2122 patients who underwent 1 of 6 elective surgical

  14. Which Teachers Choose a Defined Contribution Pension Plan? Evidence from the Florida Retirement System

    Science.gov (United States)

    Chingos, Matthew M.; West, Martin R.

    2015-01-01

    Since 2002, public school teachers in Florida have been permitted to choose between a defined benefit (DB) and a defined contribution (DC) retirement plan. We exploit this unique policy environment to study new teachers' revealed preferences over pension plan structures. Roughly 30 percent of teachers hired between 2003 and 2008 selected the DC…

  15. Elementary School-Age Children's Capacity To Choose Positive Diagnostic and Negative Diagnostic Tests.

    Science.gov (United States)

    Samuels, Mark C.; McDonald, John

    2002-01-01

    Two experiments compared 10-year-olds' and adults' ability to choose positive and negative diagnostic tests over positive and negative nondiagnostic tests. Findings indicated that both age groups were more likely to prefer positive diagnostic tests over positive nondiagnostic tests, although only adults showed a significant preference for negative…

  16. Empirical Investigation into Motives for Choosing Web-Based Distance Learning Programs

    Science.gov (United States)

    Alkhattabi, Mona

    2016-01-01

    Today, in association with rapid social and economic changes, there is an increasing level of demand for distance and online learning programs. This study will focus on identifying the main motivational factors for choosing a web-based distance-learning program. Moreover, it will investigate how these factors relate to age, gender, marital status…

  17. First-year dental students’ motivation and attitudes for choosing the dental profession

    Directory of Open Access Journals (Sweden)

    Nadya Avramova

    2014-11-01

    Full Text Available Objective. To determine first-year dental students’ current motivation and attitudes for choosing the dental profession at the Faculty of Dental Medicine, Medical University – Sofia, Bulgaria. Material and methods. An anonymous questionnaire, consisting of 12 questions about students’ socio-demographic profile and their motivation for choosing dentistry, was administered to 119 first-year dental students at the Faculty of Dental Medicine of the Medical University of Sofia. The study was conducted at the beginning of the 2012-2013 academic year. The data was processed and analyzed with the following software: Microsoft Windows Server 2008 R2; Microsoft SQL Server 2008; Internet Information Server 7.5.; Microsoft SharePoint Server 2010. Results. The majority of the students (73% were self-motivated for choosing dentistry as a career; 61% of them did not have relatives in the medical profession; 43% chose dental medicine because it is a prestigious, humane and noble profession; 50% – for financial security; 59% – because of the independence that it provides. There were no significant differences in the motivation between males and females. Conclusion. Independence, financial security and ‘prestige’ were the predominant motivating factors in this group of first-year dental students. Determining the reasons for choosing dentistry has important implications for the selection and training of students as well as for their future job satisfaction.

  18. Fuzzy Reasoning Methods by Choosing Different Fuzzy Counters and Analysis of Effect

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Different fuzzy reasoning methods were gave by choosing different fuzzy counters. This article generally introduced the basic structure of fuzzy controller,and compared and analysised the reasoning effect of fuzzy reasoning methods and the effect of computer simulating control basicly on different fuzzy counters.

  19. A Ray of Light: A Mixed-Methods Approach to Understanding Why Parents Choose Montessori Education

    Science.gov (United States)

    Zarybnisky, Emily M.

    2010-01-01

    This study explored why parents choose Montessori schools for their children. Parents from two public (n = 40) and two private (n = 10) Montessori schools responded to a written survey designed to discern what characteristics parents valued in making their decision. Descriptive statistics, t-tests, and chi-square tests were used to understand the…

  20. Why political context is key in determining the parties interest groups choose to collaborate with

    NARCIS (Netherlands)

    Otjes, Simon; Rasmussen, Anne

    2015-01-01

    When interest groups choose to collaborate with political parties what determines the type of party they opt to work with? Anne Rasmussen and Simon Otjes write that the two key elements shaping this decision are typically the ideological similarities between the interest group and the party, togethe

  1. Refined Method for Choosing a Security Solution for Mobile Application – Web Service Interactions

    OpenAIRE

    Silvia Trif; Adrian Visoiu

    2011-01-01

    This paper aims to present a refined algorithm for choosing the appropriate security implementation for mobile applications connecting to web services. Common security scenarios are presented. Each scenario has several characteristics associated. The correlations between these security scenarios characteristics are computed and selected only the characteristics that are less correlated. The proposed algorithm inventories the available scenarios, inventories the requirements and selects the se...

  2. A Method for Choosing an Initial Time Eigenstate in Classical and Quantum Systems

    Directory of Open Access Journals (Sweden)

    Mónica Noemí Jiménez-García

    2013-06-01

    Full Text Available A subject of interest in classical and quantum mechanics is the development of the appropriate treatment of the time variable. In this paper we introduce a method of choosing the initial time eigensurface and how this method can be used to generate time-energy coordinates and, consequently, time-energy representations for classical and quantum systems.

  3. SOLUTION FOR ICHTHYOFAUNA MIGRATION UPSTREAM- DOWNSTREAM OF THE TWO SPILLWAYS LOCATED NEAR MANASTUR DAM ON THE SOMESUL MIC RIVER IN THE CLUJ NAPOCA CITY (ROMÂNIA

    Directory of Open Access Journals (Sweden)

    Razvan VOICU

    2015-06-01

    Full Text Available Longitudinal connectivity represent the way in which organisms move the energy and material exchanges located throughout the water. Fragmentation the longitudinal connectivity of watercourses caused by dams or other hydrotechnical constructions represent a major impact on sediment transport, hydrological regime, downstream moving and biota migration. The hydromorphological elements (river continuity, as well as chemical, biological, physicochemical elements characterize the ecological status of rivers.Migratory fish species: nase (Chondrostoma nasus - protected by Bern Convention - Appendix III and barbel (Barbus barbus - rare species, protected Habitats Directive (Annex V, annex 4A of Low nr.462 and Red List of RBDD are blocked but the Hydrotechnical constructions (discharge sills, dams etc located across the watercourse Somes Mic River. One of the important think of this system is the gravitational fall of water. This solution will lead to the restoration of the longitudinal connection of the Someşul Mic River in the Manastur neighborhood. România is part of the European Union and it has the obligation to implement the provisions of the Water Framework Directive 2000/60/EC, transposed into Romanian legislation by the Water Law 107/1996 as supplemented and amended (Act 310/2004. This engineering solution for fish fauna migration upstream – downstream of the spillways supports the Water Framework Directive 2000/60/EC, transposed into Romanian legislation by the Water Law 107/1996 as supplemented and amended (Act 310/2004.

  4. Liberalismo vs. neo-fascismo: perspectiva sociosemiótica y análisis político del cómic Guerra Civil

    Directory of Open Access Journals (Sweden)

    Liber Daniel Cuñarro Conde

    2014-01-01

    Full Text Available La presente investigación analiza desde una perspectiva sociosemiótica y política algunos de los aspectos más relevantes del cómic Guerra Civil de Marvel como expresión de los eventos del 11 de septiembre de 2001 en los Estados Unidos de América. Dicho texto se examina desde los enfoques postulados por Greimas (1966 y Eco (1993. A tal efecto se ha seleccionado un corpus concreto, constituido por los siete ejemplares que representan la historia principal de la serie titulada Civil War, en su lenguaje original. Para lograr la comprensión del programa narrativo del cómic, este estudio proporciona el antetexto y la información pertinente para hacer posible una interpretación de los elementos políticos e ideológicos de la Guerra Civil de Marvel, su relación con la representación alegórica de los hechos históricos y su textualización como expresión simbólica de la sociedad contemporánea.

  5. The Comparison of Iranian and Foreign Students’ Motivations to Choose Dentistry Field of Study

    Directory of Open Access Journals (Sweden)

    Abdolreza Gilavand

    2016-06-01

    Full Text Available Background Because of some special and privileged attractions of dentistry discipline, the first choice of volunteers who want to enter university is dentistry. The students usually choose it regardless to their interests and talents. Therefore, this study aimed to investigate Iranian and Foreign student’s motivations to choose dentistry field of study. Materials and Methods We searched international databases such as PubMed, Scopus, EMBASE, Cochrane Library, and Iranian databases such as SID, Magiran, Iranmedex using a searching strategy during 2000 to 2015 years. Database without language restriction, since 2000 sources, with the MeSH term "Choose dentistry field" AND "Students". At first, in the initial search,152 articles were found, and finally, 51 of them which were related to the subject of this research were used. Results In general, the motivation of students to choose field of study in Iranain and Foreign students include the following:: an independent office or job independence, high economic income, appropriate social status,  job attractiveness of dentistry, appropriate job position, individual longing, help others, top rank of student in the university entrance exam, continue to study at specialized PhD in one of dentistry trends, successful marriage nd interest in the field of dentistry. Conclusion It seems that with regard to the high unemployment rate of university graduates in Iran, the most important incentives of applicants who want to enter the dentistry discipline are high income and  particular social prestige at this major. Moreover, high income and independent job situations are the most important factors in Foreign students for choosing this filed of study in the overseas studies.

  6. Choose and Book: a sociological analysis of 'resistance' to an expert system.

    Science.gov (United States)

    Greenhalgh, Trisha; Stones, Rob; Swinglehurst, Deborah

    2014-03-01

    In 2004, the English Department of Health introduced a technology (Choose and Book) designed to help general practitioners and patients book hospital outpatient appointments. It was anticipated that remote booking would become standard practice once technical challenges were overcome. But despite political pressure and financial incentives, Choose and Book remained unpopular and was generally used reluctantly if at all. Policymakers framed this as a problem of 'clinician resistance'. We considered Choose and Book from a sociological perspective. Our dataset, drawn from a qualitative study of computer use in general practice, comprised background documents, field notes, interviews, clinical consultations (directly observed and videotaped) and naturally occurring talk relating to referral to hospital in four general practices. We used strong structuration theory, Giddens' conceptualisation of expert systems, and sensitivity to other sociological perspectives on technology, institutions and professional values to examine the relationship between the external environment, the evolving technology and actions of human agents (GPs, administrators, managers and patients). Choose and Book had the characteristics of an expert system. It served to 'empty out' the content of the consultation as the abstract knowledge it contained was assumed to have universal validity and to over-ride the clinician's application of local knowledge and practical wisdom. Sick patients were incorrectly assumed to behave as rational choosers, able and willing to decide between potential options using abstracted codified information. Our analysis revealed four foci of resistance: to the policy of choice that Choose and Book symbolised and purported to deliver; to accommodating the technology's socio-material constraints; to interference with doctors' contextual judgements; and to adjusting to the altered social relations consequent on its use. We conclude that 'resistance' is a complex phenomenon

  7. Autoras contemporáneas en la historieta española. Revisión de la etiqueta ‘cómic femenino’

    Directory of Open Access Journals (Sweden)

    Cortijo, Adela

    2011-09-01

    Full Text Available This article, whose title is so generic, does not intend to be an exhaustive and historiographic list of women authoring contemporary Spanish comics. A priori, the deficiencies of the global label “woman comic” are questioned and the representative work of a group of draftswomen and scriptwriters is shown, since the 1980 decade (Madriz, El Cairo and El Víbora to nowadays publications: Laura Pérez-Vernetti, Ana Juan, Ana Miralles, Sonia Pulido and Clara- Tanit. These authors are linked by a generational bond and offer a series of sights, paintstrokes, subjects and diverse plastic styles. The woman production phenomenon is observed along with its reception in ad hoc-collections published by some publishing houses through retrospectives, symposium and exhibitions which are still alerting about the so needed visibility. At the same time, both the atraction and the tendency towards the drawing art and equally the links between comic made by women and the concept related to the author comic, literature and egotistic tales are studied too.

    Este artículo, de título tan genérico, no pretende ser un listado exhaustivo e historiográfico de autoras de historieta contemporánea española. En esta aproximación se cuestionan a priori las deficiencias de la etiqueta global de “cómic femenino”, y se muestra el trabajo representativo de una serie de dibujantes y guionistas mujeres, desde los años ochenta (desde Madriz, El Cairo y El Víbora hasta la actualidad: Laura Pérez-Vernetti, Ana Juan, Ana Miralles, Sonia Pulido y Clara-Tanit. Autoras que se hilvanan en un hilo generacional y que ofrecen una explosión de miradas, de trazos, temas y estilos plásticos distintos. Se observa el fenómeno de la producción femenina y su recepción a través de colecciones ad hoc de algunas casas de edición, de retrospectivas, coloquios y exposiciones, que siguen alertando de la necesidad de una visibilidad

  8. Why and when do Danish medical doctors choose to become a general practitioner?

    DEFF Research Database (Denmark)

    Lewandowska, Karolina; Kjær, Niels Kristian; Lillevang, Gunver

    Background and Aim: Continued supply of qualified general practitioners is essential for the vitality of the primary health care sector. In Denmark however we have observed a decline in the number of applicants for our family medicine specialist training program, leaving some posts vacant. The aim...... of study is to examine why and when Danish junior doctors choose family medicine as their future specialty. Method: We carried out two focus group interviews with medical doctors from two regions. An academic employee from the Danish College of Family Medicine mediated the interviews assisted by a family......-graduate training the structure of the postgraduate educational program, working conditions, respect for general practice, uncertainty about the future for general practice as a profession, when did I decide to choose family medicine. Out of these themes we identified factors, which influenced the choice...

  9. Empowering Learners to Choose the Difficulty Level of Problems Based on Their Learning Needs

    Directory of Open Access Journals (Sweden)

    Janet Mannheimer Zydney

    2010-08-01

    Full Text Available Research has found that increasing learner control offers several benefits, including increased motivation, attitude, and learning. The goal of the present study was to determine how prior math achievement influences students' selection of the difficulty level of problems within Math Pursuits, a hypermedia learning program. Math Pursuits was designed to help children understand mathematics by discovering how it relates to the world around them. The program presented each learner with an adjustable level of challenge, along with the necessary scaffolding to support success. The researchers hypothesized that students with lower math skills would choose to start with a lower difficultly level; whereas, students with higher math skills would begin the program by choosing a question with a higher level of difficulty. Results supported these hypotheses. This research also examined the motivational framework guiding students' selection of problem difficulty.

  10. Choosing Teaching as a Career: Importance of the Type of Motivation in Career Choices

    Directory of Open Access Journals (Sweden)

    Robert Tomšik

    2016-08-01

    Full Text Available This research looks into what are Extrinsic, Intrinsic and Altruistic motives and their importance when students are choosing their career. The study involved 324 teacher trainees in their first year of bachelor studies. The types of motivation when choosing teaching career were studied by SMVUP2-S (Teaching Career Choice Scale. The model of motivation types was supplemented by subscales: Influence by other, Career growth and Alternative choice. Objective of the study was to show the relationship between these variables. Results from the research showed that influence by other and alternative choice of teaching career were in a negative relation with interest and skills/experience that this career requires and students should have.

  11. Why do young Arabs in Denmark choose to study their heritage language at the university?

    DEFF Research Database (Denmark)

    Dhahir, Omar

    2016-01-01

    the job perspective. It also found that the informants speak their respective dialects of Arabic at a native-like level of proficiency. Moreover, the study found that the families have exerted an intensive and organized effort to motivate the informants to learn Arabic due to its extreme relevance......This article reports on a study of the phenomenon that an increasing number of young Arabs in Denmark are choosing to study their heritage language at the university. The study aimed at investigating three elements: the motivation behind choosing to study the heritage language at the university......; whether the informants had learned/maintained Arabic before starting at the university; and the role of the families in motivating the informants to learn and study Arabic. The informants are students just enrolled at the University of Southern Denmark in autumn 2012. A mixed method was used...

  12. The capacity to choose: reformulating the concept of choice in economic theory

    Directory of Open Access Journals (Sweden)

    Mark S. Peacock

    2011-05-01

    Full Text Available Despite being conceived as a ‘theory of rational choice’, orthodox economics fails to ascribe to human beings the ability to choose in a meaningful sense, something philosophical approaches to economics have long noted and tried to remedy. Tony Lawson’s critical realism is one attempt at a remedy. If, following Lawson, one conceives of choice as a ‘capacity’ of human beings, critical realist analysis suggests a distinction between humans’ possession and their exercise of this capacity. If one can sustain this distinction, one should be able to distinguish cases in which agents actually exercise their capacity to choose from those in which they do not. Investigation of this distinction does not, however, lead to the desired distinction between such cases. Consequently, a reformulation of the notion of choice is required. An implication for economic theory – namely, the possibility of conceptualizing ‘exploitation’ – is discussed.

  13. 20 CFR 30.405 - After selecting a treating physician, may an employee choose to be treated by another physician...

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false After selecting a treating physician, may an employee choose to be treated by another physician instead? 30.405 Section 30.405 Employees' Benefits... § 30.405 After selecting a treating physician, may an employee choose to be treated by...

  14. 40 CFR 270.180 - For what reasons may the Director choose to revoke and reissue my final RAP?

    Science.gov (United States)

    2010-07-01

    ... choose to revoke and reissue my final RAP? 270.180 Section 270.180 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.180 For what reasons may the Director choose to revoke and reissue my final...

  15. MIC-SVM: Designing A Highly Efficient Support Vector Machine For Advanced Modern Multi-Core and Many-Core Architectures

    Energy Technology Data Exchange (ETDEWEB)

    You, Yang; Song, Shuaiwen; Fu, Haohuan; Marquez, Andres; Mehri Dehanavi, Maryam; Barker, Kevin J.; Cameron, Kirk; Randles, Amanda; Yang, Guangwen

    2014-08-16

    Support Vector Machine (SVM) has been widely used in data-mining and Big Data applications as modern commercial databases start to attach an increasing importance to the analytic capabilities. In recent years, SVM was adapted to the field of High Performance Computing for power/performance prediction, auto-tuning, and runtime scheduling. However, even at the risk of losing prediction accuracy due to insufficient runtime information, researchers can only afford to apply offline model training to avoid significant runtime training overhead. To address the challenges above, we designed and implemented MICSVM, a highly efficient parallel SVM for x86 based multi-core and many core architectures, such as the Intel Ivy Bridge CPUs and Intel Xeon Phi coprocessor (MIC).

  16. Cálcul estructural d'un Observatori Astronómic situat a La Palma (Canàries), segons Normativa ENV 1993-1-1

    OpenAIRE

    Lacroizette i Mañas, Xavier

    2004-01-01

    Premi al millor Projecte de Fi de Carrera presentat durant el curs 2004-2005 en l'àmbit de Construcció que atorga el GREMI DE CONSTRUCTORS D'OBRES El present Projecte de Fi de Carrera està dedicat al disseny i càlcul estructural d’un dels complexes que composen l’Observatori Astronòmic del "Roque de los Muchachos", situat a la illa de la Palma (Canàries). Els diferents càlculs de la estructura metàl·lica s’han realitzat segons la normativa experimental europea ENV 1993-1-1, més coneg...

  17. Hybrid MPI/OpenMP First Principles Materials Science Codes for Intel Xeon Phi (MIC) based HPC: The Petascale and Beyond

    Science.gov (United States)

    Canning, Andrew; Deslippe, Jack; Chelikowsky, James; Louie, Steven G.

    2015-03-01

    Exploiting the full potential of present petascale and future exascale supercomputers based on many core chips requires a high level of threading on the node as well as reduced communications between the nodes to scale to large node counts. We will present results for a variety of first principles materials science codes (Berkeley-GW, PARATEC, PARSEC) on Intel Xeon Phi (MIC) based supercomputers for algorithms using hybrid OpenMP/MPI parallelism to obtain both efficiently threaded single chip performance and parallel scaling to large node counts. Support provided through the SciDAC program funded by U.S. Department of Energy, Office of Science, ASCR and BES under Contract No. DE-AC02-05CH11231 at LBNL and Award No. DESC0008877 at UT, Austin.

  18. A THEORETICAL ANALYSIS OF KEY POINTS WHEN CHOOSING OPEN SOURCE ERP SYSTEMS

    OpenAIRE

    Fernando Gustavo Dos Santos Gripe; Ildeberto Aparecido Rodello

    2011-01-01

    The present work is aimed at presenting a theoretical analysis of the main features of Open Source ERP systems, herein identified as success technical factors, in order to contribute to the establishment of parameters to be used in decision-making processes when choosing a system which fulfills the organization´s needs. Initially, the life cycle of ERP systems is contextualized, highlighting the features of Open Source ERP systems. As a result, it was verified that, when carefully analyzed, t...

  19. Reward redemption effects in a loyalty program when customers choose how much and when to redeem

    OpenAIRE

    Dorotic, Matilda; Peter C. Verhoef; Fok, Dennis; Bijmolt, Tammo H. A.

    2014-01-01

    The redemption of loyalty program (LP) rewards has an important impact on LP members’ behavior, particularly on purchase behavior before and after redeeming a reward. However, little is known about the interplay between members’ purchase and redemption behavior when members are not pressured with points expiration and they choose for themselves when and how much to redeem. In this context, the effects of redemption are not straightforward, as little additional effort is required from an LP me...

  20. A spider that feeds indirectly on vertebrate blood by choosing female mosquitoes as prey

    OpenAIRE

    Robert R. Jackson; Nelson, Ximena J.; Sune, Godfrey O.

    2005-01-01

    Spiders do not feed directly on vertebrate blood, but a small East African jumping spider (Salticidae), Evarcha culicivora, feeds indirectly on vertebrate blood by choosing as preferred prey female mosquitoes that have had recent blood meals. Experiments show that this spider can identify its preferred prey by sight alone and by odor alone. When presented with two types of size-matched motionless lures, E. culicivora consistently chose blood-fed female mosquitoes in preference to nonmosquito ...

  1. Motivation of foreign degree students to choose ABC University for their undergraduate studies

    OpenAIRE

    Thapa, Suman; Phung, Mai Anh

    2013-01-01

    Every year, the number of foreign degree students is increasing in Finnish universities. These foreign students come from a wide range of nations all over the world. Being one of the best universities of applied sciences in Helsinki, Finland, each year ABC University receives applications of students from Vietnam, China, Nepal, Bangladesh, Russia, various African countries and so on. The aim of this qualitative research is to investigate why foreign degree students choose ABC University as th...

  2. Factors influencing a patient's decision to choose the type of treatment to improve dental esthetics

    OpenAIRE

    Gržić Renata; Špalj Stjepan; Lajnert Vlatka; Glavičić Snježana; Uhač Ivone; Kovačević-Pavičić Daniela

    2012-01-01

    Backgroung/Aim. Interest in dental esthetics has increased rapidly during the last few decades among both patients and dentists, and the creation of a natural dental appearance has become an important task in all fields of dentistry, especially in prosthodontics and restorative dentistry. The aim of this research was to investigate factors influencing a patient's decision to choose the type of treatment to improve dental esthetics. Methods. A total of 700 Caucasian subjects participated...

  3. Choosing Wisely®: A case study of constructive engagement in health policy.

    Science.gov (United States)

    Wolfson, Daniel; Suchman, Anthony

    2016-09-01

    Choosing Wisely began at a time when a polarized national debate on healthcare reform stymied effective conversation on effective and efficient resource use. The ABIM Foundation sought to change attitudes and culture and promote the idea that removing waste is an integral component of providing high quality care by using an approach of constructive engagement to persuade specialty societies to identify five wasteful tests or treatments within their field. PMID:27637831

  4. Linguistic False Friends and Expected Food Markets: What can Make Consumers Not Choose Your Product?

    OpenAIRE

    Fauquet-Alekhine, Philippe; Fauquet-Alekhine-Pavlovskaia, Elena

    2011-01-01

    Many researches have been done concerning the study of parameters which make people choose or not such product on the market. Concerning food industry, scientists have been involved in the analysis of technical parameters (nutrition, health characteristics) and their perception by the consumer, and in the analysis of psycho-sociological parameters linked with the perception of the product, or emotion associated with food or its environment. Other parameters investigated are suspicion of novel...

  5. How do people choose their commuting mode? An evolutionary approach to transport choices

    OpenAIRE

    Borghesi, Simone; Calastri, Chiara; Fagiolo, Giorgio

    2014-01-01

    The issue of transportation is of primary importance in our societies. A large share of green-house gases is generated by the transport sector, and road casualties are one am ong the most common causes of death. In the present work, we study commuter choice between alternative transport modes using an evolutionary-game model, wherein commuters can choose between using their private car or taking the bus. We examine the possible dynamics that can emerge in a homogeneous urban population, where...

  6. A qualitative study of the factors that influence mothers when choosing drinks for their young children

    OpenAIRE

    Hoare, Alexandria; Virgo-Milton, Monica; Boak, Rachel; Gold, Lisa; Waters, Elizabeth; Gussy, Mark; Calache, Hanny; Smith, Michael; de Silva, Andrea M.

    2014-01-01

    Background The consumption of sweetened beverages is a known common risk factor for the development of obesity and dental caries in children and children consume sweet drinks frequently and in large volumes from an early age. The aim of this study was to examine factors that influence mothers when choosing drinks for their children. Method Semi-structured interviews (n = 32) were conducted with a purposive sample of mothers of young children from Victoria’s Barwon South Western Region (select...

  7. Vietnamese Students' Decision Making Process on Choosing a Study Destination and Its Marketing Implications

    OpenAIRE

    Tran, Cong Tuong Thuy

    2014-01-01

    Recently, internationality has become a focus of many higher education institutions. It has been proven to bring about lots of benefits for the institution as well as the host country, such as improvements in research ability and increase in GDP. Kajaani University of Applied Sciences has seen a decrease in the number of Vietnamese students, which lowers the internationality of the school. Therefore, this research was conducted with a view to exploring how Vietnamese students choose their stu...

  8. Comparison of disc and MIC reduction methods with polymerase chain reaction for the detection of metallo-β-lactamase in Pseudomonas aeruginosa

    Directory of Open Access Journals (Sweden)

    S Buchunde

    2012-01-01

    Full Text Available Purpose: The present study was undertaken to evaluate the screening antibiotic, confirmatory phenotypic test and agent against PCR as gold standard and to detect the prevalent MBL gene. Materials and Methods: Three hundred and twenty-six Pseudomonas aeruginosa isolates were screened for resistance to Imipenem (IPM, Meropemem (MEM and Ceftazidime (CAZ by disc diffusion. Isolates resistant to any of these were considered screen test-positive for MBL and were subjected to Double disc synergy test (DDST and Disc potentiation test (DPT: Using IPM, MEM and CAZ alone and with EDTA, Minimum inhibitory concentration (MIC reduction [four-fold or more reduction in MIC of IPM and MEM in presence of chelators: EDTA and 1,10-phenanthroline (EPI/EPM: EDTA-phenanthroline- Imipenem/Meropenem Broth Microdilution method] and polymerase chain reaction (PCR for blaIMP and blaVIM . Results: Screen test-positives by MEM and CAZ were 19.3% as against 17.8% by IPM. MEMDDST, DPT and EPM confirmed 100% screen-test positives as against 93.7% by CAZ DDST and DPT-2, 76.2% by CAZ DPT-1, 88.9% by IPM DDST, 85.7% by IPM DPT-1 and 92.1% by EPI. IPMand CAZ DDST together confirmed 100% while IPM and CAZ DPT-2 confirmed 96.8%. All 63 screen-test positives showed the presence of blaVIM . Conclusions: MEM was found to be the best screening and confirmatory agent for MBL detection and blaVIM was found to be the prevalent MBL gene in this part of the country.

  9. Choosing wisely: Review and commentary on anti-nuclear antibody (ANA) testing.

    Science.gov (United States)

    Fritzler, Marvin J

    2016-03-01

    Choosing Wisely®: Next Steps in Improving Healthcare Value is an initiative of the American Board of Internal Medicine (ABIM) Foundation. The driving forces for the Choosing Wisely (CW) campaign include rising and unstainable health care expenditures and evidence that there is lack of fiscal stewardship of health care resources. The American College of Rheumatology and the Canadian Rheumatology Association published their top five Choosing Wisely recommendations, the first of which pertained to antinuclear antibodies (ANA) and ANA subserology testing. Concerns about the wasteful use of these tests prompted an analysis of the expenditures attributable to ANA testing as a proportion of total health care expenditures and based on a financial model was in the range of 0.00125%. It is suggested that if the sole use of ANA testing is to add evidence to support a diagnosis when the pre-test probability is high, then the ANA test has limited clinical value. Accordingly, the goal of ANA testing needs to be reconsidered and expanded beyond an approach to simply confirming a diagnosis with 'intention to treat' to a goal of case finding of 'pre- or early disease' with an 'intent to prevent' disease. This an area where more significant inroads can be made in preventing end organ disease and thereby reducing health care expenditures HCE. One CW recommendation that bears emphasizing is that, with a few possible exceptions, repeat ANA or ANA subserology testing has little clinical value in monitoring disease activity or predicting a flare. PMID:26687321

  10. READINESS OF SENIOR STUDENTS FROM THE CARPATHIAN TERRAIN TO CHOOSE TEACHING PROFESSION: PEDAGOGICAL AND PSYCHOLOGICAL ASPECTS

    Directory of Open Access Journals (Sweden)

    Tetyana Blyznyuk

    2015-04-01

    Full Text Available The article presented at the conference is the study of the problems of upbringing and education of senior pupils from the Carpathian mountain area. Namely the author investigates the students’ readiness for choosing the teaching profession and willingness to work at rural mountain schools. Despite the big number of teachers in the labor market of Ukraine, now the system of education meets an acute issue dealing with the selection to the pedagogical specialties talented creative young people who actually choose teaching profession by nature and strong personal will. Today there are very few teachers whose level of commitment to perform professional duties in Ukrainian education is really high, and this is especially true about mountain school teachers. This phenomenon can be partially explained by the fact that teaching profession has low prestige in our society for the recent decades (Ukrainian teachers are not well-paid, their working conditions in rural Carpathian schools leave much to be desired. Therefore the problem of readiness of high school students to perform professional-pedagogical duties is of particular relevance. The author analyzes the psychological and pedagogical basis of the presented problem, defines the essence and structure of the notion “readiness for choosing the teaching profession”. In the context of solving this issue one of the important conditions the author considers the comprehensive development of senior school students, particularly the development of their creative abilities.

  11. Motives and career barriers choosing studies in Physics and Mathematics: gender aspects

    Directory of Open Access Journals (Sweden)

    Aldona, Augustiene

    2010-04-01

    Full Text Available This article discusses the concepts of professional motivation and career barriers from the gender point of view. The research problem is expressed in the following questions: what personal and socio-cultural factors motivate young people to choose Physics and Mathematics study programmes? Are there significant differences in expression of motives and career barriers among male and female students? The sample consisted of 86 undergraduate students: 45 females and 41 male. Respondents were asked to write down their reflections as a free text answering the question why did they make such a professional choice choosing Physics and Mathematics studies. Motives that influenced the choice of Physics and Mathematics mostly expressed the dimension of self-realization and the dimension of material achievements. It was also found that both personality and social-cultural factors were important in choosing Physics and Mathematics, i.e. sensation of vocation and professional aptitude, as well as encouragement of relatives and good evaluation of future profession’s status. There were also found differences in expression of motives and career barriers among male and female students.

  12. Choosing R&D or advertising for competing firms in uncertain market

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    Bo Xie

    2014-06-01

    Full Text Available Purpose: R&D and advertising have become important means to enhance the competitiveness of firms’ products. Design an appropriate model to help the firm to make the right choice is value in supply chain.Design/methodology/approach: In considering that whether the market is completely covered or not, we build the strategy selection model for R&D and advertising for two competing firms and solve the optimal strategy.Findings and Originality/value: The research results show that when a firm does not take any measures to enhance competitiveness, another firm will neither. However when one takes measures to improve the competitiveness, another will do so, also. When two firms must choose one measure to improve the competitiveness, either in full-covered market or not full-covered market, the two firms will not choose to do advertising in step, even if the firms do not have to pay additional cost in advertising.Originality/value: In the game model, the firm could compare the own profit in different strategies. According to the above model, the firm choose the right strategy to make the profit maximize in a vertically differentiated market. And when the firm make the choice, it must think about other primary elements such as market.

  13. Factors influencing a patient's decision to choose the type of treatment to improve dental esthetics

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    Gržić Renata

    2012-01-01

    Full Text Available Backgroung/Aim. Interest in dental esthetics has increased rapidly during the last few decades among both patients and dentists, and the creation of a natural dental appearance has become an important task in all fields of dentistry, especially in prosthodontics and restorative dentistry. The aim of this research was to investigate factors influencing a patient's decision to choose the type of treatment to improve dental esthetics. Methods. A total of 700 Caucasian subjects participated in the crosssectional study (261 men, 439 women, aged 18-86 years, mean age 46.2 ± 18.6. The study included clinical examination and a self-administrated questionnaire based on self-perceived esthetics, satisfaction with the appearance of their maxillary anterior teeth and previous dental experience. Multiple logistic regression was used in statistical analysis. Results. Hiding teeth during smile was the most important predictor for choosing fixed prosthetic restorations (OR 9.1, followed by self-perceived bad fixed prosthesis, malpositioned teeth and female gender (OR 2.9, 2.4, and 1.5, respectively. The increase in satisfaction with dental appearance and previous orthodontic therapy reduced chances for seeking prosthetic therapy (each OR 0.4. The significant predictors for bleaching choosing were hiding teeth during smiling, already done bleaching, female gender, lower levels of satisfaction with dental appearance and the absence of the previous orthodontic therapy (OR 5.8, 2.4, 1.8, 0.5 and 0.4, respecitively. Hiding teeth during smile, self-perceived malposition and crowding, and lower levels of satisfaction, were significant predictors for choosing orthodontic treatment (OR 3.1, 2.4, 2.2 and 0.6, respectively. None of current dental statuses was statistically significant predictor for choosing prosthodontic, bleeching nor orthodontic therapy. Conclusion. The psychological elements and female gender are the main predictors of seeking dental therapy

  14. Choosing the polarity of the phase-encoding direction in diffusion MRI: Does it matter for group analysis?

    Science.gov (United States)

    Kennis, M; van Rooij, S J H; Kahn, R S; Geuze, E; Leemans, A

    2016-01-01

    Notorious for degrading diffusion MRI data quality are so-called susceptibility-induced off-resonance fields, which cause non-linear geometric image deformations. While acquiring additional data to correct for these distortions alleviates the adverse effects of this artifact drastically - e.g., by reversing the polarity of the phase-encoding (PE) direction - this strategy is often not an option due to scan time constraints. Especially in a clinical context, where patient comfort and safety are of paramount importance, acquisition specifications are preferred that minimize scan time, typically resulting in data obtained with only one PE direction. In this work, we investigated whether choosing a different polarity of the PE direction would affect the outcome of a specific clinical research study. To address this methodological question, fractional anisotropy (FA) estimates of FreeSurfer brain regions were obtained in civilian and combat controls, remitted posttraumatic stress disorder (PTSD) patients, and persistent PTSD patients before and after trauma-focused therapy and were compared between diffusion MRI data sets acquired with different polarities of the PE direction (posterior-to-anterior, PA and anterior-to-posterior, AP). Our results demonstrate that regional FA estimates differ on average in the order of 5% between AP and PA PE data. In addition, when comparing FA estimates between different subject groups for specific cingulum subdivisions, the conclusions for AP and PA PE data were not in agreement. These findings increase our understanding of how one of the most pronounced data artifacts in diffusion MRI can impact group analyses and should encourage users to be more cautious when interpreting and reporting study outcomes derived from data acquired along a single PE direction. PMID:27158586

  15. Choosing the polarity of the phase-encoding direction in diffusion MRI: Does it matter for group analysis?

    Directory of Open Access Journals (Sweden)

    M. Kennis

    2016-01-01

    Full Text Available Notorious for degrading diffusion MRI data quality are so-called susceptibility-induced off-resonance fields, which cause non-linear geometric image deformations. While acquiring additional data to correct for these distortions alleviates the adverse effects of this artifact drastically – e.g., by reversing the polarity of the phase-encoding (PE direction – this strategy is often not an option due to scan time constraints. Especially in a clinical context, where patient comfort and safety are of paramount importance, acquisition specifications are preferred that minimize scan time, typically resulting in data obtained with only one PE direction. In this work, we investigated whether choosing a different polarity of the PE direction would affect the outcome of a specific clinical research study. To address this methodological question, fractional anisotropy (FA estimates of FreeSurfer brain regions were obtained in civilian and combat controls, remitted posttraumatic stress disorder (PTSD patients, and persistent PTSD patients before and after trauma-focused therapy and were compared between diffusion MRI data sets acquired with different polarities of the PE direction (posterior-to-anterior, PA and anterior-to-posterior, AP. Our results demonstrate that regional FA estimates differ on average in the order of 5% between AP and PA PE data. In addition, when comparing FA estimates between different subject groups for specific cingulum subdivisions, the conclusions for AP and PA PE data were not in agreement. These findings increase our understanding of how one of the most pronounced data artifacts in diffusion MRI can impact group analyses and should encourage users to be more cautious when interpreting and reporting study outcomes derived from data acquired along a single PE direction.

  16. A 37-year-old man trying to choose a high-quality hospital: review of hospital quality indicators.

    Science.gov (United States)

    Howell, Michael D

    2009-12-01

    Mr A, a previously healthy 37-year-old man, was diagnosed as having Prinzmetal angina and a hypercoagulable state 3 years ago after an ST-elevation myocardial infarction. Now, his cardiologist is moving and Mr A must select a new physician and health system. Geographic relocation, insurance changes, and other events force millions in the United States to change physicians and hospitals every year. Mr A should begin by choosing a primary care physician, since continuity and coordination of care improves outcomes. Evidence for evaluating specific physicians is less robust, though a variety of sources are available. A broad range of detailed quality information, such as Medicare's Hospital Compare (http://www.hospitalcompare.hhs.gov/), is available for selecting a hospital. However, the relationship of these metrics to patient outcomes is variable, and different Web sites provide meaningfully different rankings and data interpretations. For Mr A in particular, a warfarin management team, the hospital's location, and a cardiologist with whom he feels comfortable and who can communicate with his primary care physician are important factors. Nevertheless, hospital quality information and metrics are an important component of the strategy Mr A should take to solve this challenging problem.

  17. VARIABLE APPROACH TO CHOOSING THE WAYS OF SCIENTIFIC AND TECHNICAL LITERATURE INTERPRETATION IN THE CONTEXT OF A PROFESSIONAL ACTIVITY

    Directory of Open Access Journals (Sweden)

    Moskvitin A. A.

    2015-09-01

    Full Text Available This article touches the current issue of variable approach to choosing the variant of scientific and technical translation. Development of Linguistics and the sciences, studying a man and his activities, and increasing the flow of information due to the rapid development of the areas of science require another approach to the development of mechanisms for the translation process. This article discusses and analyzes multidimensional models of translation, their versatility with the dynamics of the translation process. The authors consider the translation as a specific component of communication using two languages in which the problems of philosophy, psychology, physiology, sociology and linguistics are accumulated. Particular attention is paid to the problem of interpretation of the concept of "invariant", which allows the translation of scientific and technical literature to achieve adequacy of the translated text with the original one, saving the message content and statements shades that is the style of the original text. This article details the various methods of translation, their effectiveness, and the authors estimate each type of translation in terms of use for practical purposes and in view of reducing the rate of a man work and reducing the complexity of his operations

  18. Health-related restrictions of choices and choosing: implications for quality of life and clinical interventions

    Directory of Open Access Journals (Sweden)

    Barry J Gurland

    2010-08-01

    Full Text Available Barry J Gurland1, Huai Cheng2, Mathew S Maurer31Columbia University Department of Psychiatry, Stroud Center for Study of Quality of Life, New York, NY, USA; 2Anderson Cancer Center, Houston, TX, USA; 3Columbia Presbyterian Medical Center, New York, NY, USABackground: The process of “accessing choices and choosing among them” (c-c has been proposed as a model for understanding, evaluating, and assisting a patient’s management of quality of life. If desired choices are freely accessible, and the act of choosing is efficient and unconstrained, then the outcome is optimized quality of life. The c-c model fits many clinical situations where improved quality of life is a goal, and interventions may be aimed at relieving health-related restrictions of the patient’s desired activities. Aims: To determine the impact of health restrictions of choices and choosing on indicators and outcomes reflecting quality of life. Method: Secondary analysis of a community-based health survey of three ethnic groups, 65 years and older (n = 2,130, repeated after 18 months, with mortality over 6 years. Findings: Complaints of health restrictions of desired activities accounted for about half the variance of all determinants of a quality of life proxy indicator, and had a high frequency. Such complaints also predicted declines in mood and function, higher death rates, and increased service use.Conclusions: Clinical trials are warranted of the efficacy for quality of life improvement of interventions that focus on the relief of health-induced restrictions of desired activities.Keywords: choice, quality of life, aging, health restrictions

  19. The Specifics of WEB Project Management

    Directory of Open Access Journals (Sweden)

    Mirjana Marić

    2013-06-01

    Full Text Available According to the data announced by the Standish Group the failure rate of software project due to inappropriate management amounts to almost 50%. The authors of this article believe that such a high percentage could be reduced by building a model for choosing an appropriate management model. In order to set up such model, above all, it is necessary to systematise all the specifics of the web software product as the first step and a basis for further identification of key areas in managing web project development. The focus of this article is on presenting the results of the first stage of research, which encompasses the systematisation of the specifics of web software projects, and identification of the key areas that will serve as the source of key indicators of a future model for choosing the appropriate web project management models.

  20. How prevalent and costly are Choosing Wisely low-value services? Evidence from Medicare beneficiaries.

    Science.gov (United States)

    Collado, Megan

    2014-10-01

    (1) Through the Choosing Wisely initiative, medical specialty societies identified non-indicated cardiac testing in low-risk patients and short-interval dual-energy X-ray absorptiometry (DXA) or bone density testing as low-value care. (2) Nationally, 13 percent of low-risk Medicare beneficiaries received non-indicated cardiac tests, and 10 percent of DXAs reimbursed by Medicare were administered at inappropriately short intervals. There is significant geographic variation in the provision of these services. (2) Carefully designed policy and payment changes will likely prove most effective in reducing low-value care.

  1. Decision and experience: why don't we choose what makes us happy?

    Science.gov (United States)

    Hsee, Christopher K; Hastie, Reid

    2006-01-01

    Recent years have witnessed a growing interest among psychologists and other social scientists in subjective well-being and happiness. Here we review selected contributions to this development from the literature on behavioral-decision theory. In particular, we examine many, somewhat surprising, findings that show people systematically fail to predict or choose what maximizes their happiness, and we look at reasons why they fail to do so. These findings challenge a fundamental assumption that underlies popular support for consumer sovereignty and other forms of autonomy in decision-making (e.g. marriage choice), namely, the assumption that people are able to make choices in their own best interests.

  2. Method of Choosing the Information Technology System Supporting Management of the Military Aircraft Operation

    Directory of Open Access Journals (Sweden)

    Barszcz Piotr

    2014-12-01

    Full Text Available The paper presents a method of choosing the information technology system, the task of which is to support the management process of the military aircraft operation. The proposed method is based on surveys conducted among direct users of IT systems used in aviation of the Polish Armed Forces. The analysis of results of the surveys was conducted using statistical methods. The paper was completed with practical conclusions related to further usefulness of the individual information technology systems. In the future, they can be extremely useful in the process of selecting the best solutions and integration of the information technology systems

  3. CHOOSING BETWEEN SMALL AND MIDDLE ENTERPRISES AND SELFEMPLOYED PERSON IN TERMS OF TAXATION

    Directory of Open Access Journals (Sweden)

    ISPAS ROXANA

    2016-02-01

    Full Text Available This paper presents the advantages and disadvantages of small and middle enterprises (SMEs in relation with a registered sole trader (RST. This comparison is necessary since from the 1 st of January 2016, all registered sole traders are required to pay CAS (10.5% or 26.3% according to their option calculated the net revenue gained, besides the CASS of 5.5% and the income tax of 16%. At the same time, a part of the private entrepreneurs will have to choose if they suspend or cease their activity under the form of registered sole trader or establish a small enterprise.

  4. CHOOSING BETWEEN SMALL AND MIDDLE ENTERPRISES AND SELFEMPLOYED PERSON IN TERMS OF TAXATION

    OpenAIRE

    ISPAS ROXANA

    2016-01-01

    This paper presents the advantages and disadvantages of small and middle enterprises (SMEs) in relation with a registered sole trader (RST). This comparison is necessary since from the 1 st of January 2016, all registered sole traders are required to pay CAS (10.5% or 26.3% according to their option) calculated the net revenue gained, besides the CASS of 5.5% and the income tax of 16%. At the same time, a part of the private entrepreneurs will have to choose if they suspend or cea...

  5. Decision support system to help choose between an ITE or a BTE hearing aid

    OpenAIRE

    Anwar, Naveed; Oakes, Michael

    2011-01-01

    A decision support system (DSS) is used for analysing a situation and making decisions. The goal of this research is to mine a large set of heterogeneous audiology data and create a DSS to help audiology technicians to choose between an ITE or BTE hearing aid. Although, in many cases such a choice is clear cut, but at other times this system could be used as a second opinion to predict the hearing aid type. A number of data mining techniques, such as clustering of audiograms, association anal...

  6. A prosocial media strategy: "youth against violence: choose to de-fuse".

    Science.gov (United States)

    Zimmerman, J D

    1996-07-01

    The role of television in encouraging youth violence, and its potential as a prosocial teaching tool are examined. A media strategy developed by New York City in collaboration with inner-city youth exposed to violence, which focused on positive peer pressure for choosing nonviolent solutions to conflict is then delineated, along with the community and media coverage that followed. The effectiveness of the televised public service announcements appeared to be associated with the use of emotionally charged, real-life situations, speech, and body language by characters culturally appropriate to the target audience of at-risk youth. PMID:8827259

  7. Outsourcing your medical practice call center: how to choose a vendor to ensure regulatory compliance.

    Science.gov (United States)

    Johnson, Bill

    2014-01-01

    Medical practices receive hundreds if not thousands of calls every week from patients, payers, pharmacies, and others. Outsourcing call centers can be a smart move to improve efficiency, lower costs, improve customer care, ensure proper payer management, and ensure regulatory compliance. This article discusses how to know when it's time to move to an outsourced call center, the benefits of making the move, how to choose the right call center, and how to make the transition. It also provides tips on how to manage the call center to ensure the objectives are being met.

  8. Determination Of Prevalence Of Methicillin Resistant Staphylococcus Infections Through Measurement Of Mics Of S. Aureus Isolates Imam Hospital (November 2001 To January 2003

    Directory of Open Access Journals (Sweden)

    M. Mohraz

    2003-08-01

    Full Text Available Methicillin resistant staphylococcus aureus (MRSA is a predominantly nosocomial pathogen which its prevalence has increased worldwide over the past three decades."nMaterials and Methods: This is a descriptive cross-sectional study. The following study is designed for determination of prevalence of MRSA infection through measurement of MICs of S. aureus isolates in Imam Khomeini Hospital (a teaching hospital from November 2001 to January 2003. A total number of 402 specimens were isolated and specified as S. aureus by Imam Khomeini microbiology lab. Demographic and clinical data and results of MIC were analysed by Epilnfo 6 software."nResults: During the study, staphylococcus aureus was isolated from 402 patients that 187 (46.5% of isolates were MRSA and 215 (53.5% were MSSA. Of 402 patients, 254 (63.2% were male and 148 (36.8% were female. The difference of the prevalence of MRSA between males and females was not statistically significant (p= 0.09. The difference in mean age in MRSA and MSSA groups was not statistically significant (p= 0.55. In the age group of < 1 month, the prevalence of MRSA infection was significantly higher than other groups (P= 0.01."nConclusion: In this study, the prevalence of MRSA infection was increased, statistically significant in the presence of such factors as sepsis, longer duration of hospitalization, hospital- acquired infection, history of invasive procedure, history of antimicrobials used in the past 3 months and type of administered antimicrobial (s, history of hospitalization in the preceding year, certain underlying diseases, type of admission ward, type of infection, type of specimen and type of administered antimicrobials for treatment. Surprisingly, the prevalence of MRSA infection in IV drug user group was low that was statistically significant (p< 0.0001. In this study, there was no statistically significant difference in outcome between MRSA infected and MSSA infected patients. Based on results of

  9. Modeling the Intention to Choose Natural Vaginal Delivery: Using Reasoned Action and Social Cognitive Theories

    Directory of Open Access Journals (Sweden)

    Safieh Kanani

    2015-03-01

    Full Text Available Background: The Behavioral Intention Model is one of the best and most widely models used regarding attitude of behavioral of pregnancy and decrease the rate of cesarean section (CS among pregnant women, except effect of atti-tude and subjective norms on behavioral intention. Two variables of self-efficacy, and outcome expectation, relate to individual’s behavior in an upcoming situation, and both of them are important at the development of behavior. The purpose of the present study was to develop a model to explain women’s inten-tion to choose natural vaginal delivery (NVD. The variables of self-efficacy and outcome expectations, derived from Bandura’s Social Cognitive Theory, and Behavioral Intention Model constructs were used to define the model.Methods: The study was descriptive and cross-sectional in nature and took place in Pars Abad, Iran in 2014. The non-probability sample consisted of 200 pregnant women who voluntarily participated in the study and provided the data. SPSS 21 and MPLUS 6.8 were employed to analyze the data.Results: Self-efficacy, outcome expectations, and attitude toward NVD were associated with intention to choose the NVD.Conclusion: The study findings may play a role in designing educational inter-ventions aimed at influencing the NVD and improving childbirth programs.

  10. Why do different people choose different university degrees? Motivation and the choice of degree.

    Science.gov (United States)

    Skatova, Anya; Ferguson, Eamonn

    2014-01-01

    Different people choose undergraduate degrees to study at university for different reasons. To date, there have been limited attempts to identify individual differences in motivation that drive undergraduate degree choice. We identified that people choose university degrees for four reasons: career concerns (Career), intrinsic interest in the subject (Interest), an opportunity to help others (Helping) and because they are looking for an easy option to get into higher education (Loafing). We investigated whether these motivations apply to the choice of undergraduate degree in two samples: (1) undergraduate (N = 989) and (2) prospective (N = 896) students. We developed the Motivations Influencing Course Choice (MICC) questionnaire to measure these motivations. Scales of Helping, Career, Loafing, and Interest showed good psychometric properties, showed validity with respect to general life goals and personality traits, and predicted actual and prospective degree choices. We demonstrated that medical degrees were chosen due to a mixture of Helping and Career, while engineering degrees were associated with Career and low Interest in the degree. The choice of arts and humanities degrees was driven by Interest and low concern about future career, accompanied with high Loafing. We also demonstrated gender differences: females were high in Helping (both samples) and Interest (only in the undergraduate sample) motivation, while males scored higher in Career (only in the undergraduate sample) and Loafing (both samples). The findings can feed into both theoretical accounts of proximal motivation as well as provide help to improve degree programmes at universities and support better career advice. PMID:25431561

  11. Staying home to give birth: why women in the United States choose home birth.

    Science.gov (United States)

    Boucher, Debora; Bennett, Catherine; McFarlin, Barbara; Freeze, Rixa

    2009-01-01

    Approximately 1% of American women give birth at home and face substantial obstacles when they make this choice. This study describes the reasons that women in the United States choose home birth. A qualitative descriptive secondary analysis was conducted in a previously collected dataset obtained via an online survey. The sample consisted of 160 women who were US residents and planned a home birth at least once. Content analysis was used to study the responses from women to one essay question: "Why did you choose home birth?" Women who participated in the study were mostly married (91%) and white (87%). The majority (62%) had a college education. Our analysis revealed 508 separate statements about why these women chose home birth. Responses were coded and categorized into 26 common themes. The most common reasons given for wanting to birth at home were: 1) safety (n = 38); 2) avoidance of unnecessary medical interventions common in hospital births (n = 38); 3) previous negative hospital experience (n = 37); 4) more control (n = 35); and 5) comfortable, familiar environment (n = 30). Another dominant theme was women's trust in the birth process (n = 25). Women equated medical intervention with reduced safety and trusted their bodies' inherent ability to give birth without interference. PMID:19249657

  12. Selective Cooperation in Early Childhood – How to Choose Models and Partners

    Science.gov (United States)

    Hermes, Jonas; Behne, Tanya; Studte, Kristin; Zeyen, Anna-Maria; Gräfenhain, Maria; Rakoczy, Hannes

    2016-01-01

    Cooperation is essential for human society, and children engage in cooperation from early on. It is unclear, however, how children select their partners for cooperation. We know that children choose selectively whom to learn from (e.g. preferring reliable over unreliable models) on a rational basis. The present study investigated whether children (and adults) also choose their cooperative partners selectively and what model characteristics they regard as important for cooperative partners and for informants about novel words. Three- and four-year-old children (N = 64) and adults (N = 14) saw contrasting pairs of models differing either in physical strength or in accuracy (in labeling known objects). Participants then performed different tasks (cooperative problem solving and word learning) requiring the choice of a partner or informant. Both children and adults chose their cooperative partners selectively. Moreover they showed the same pattern of selective model choice, regarding a wide range of model characteristics as important for cooperation (preferring both the strong and the accurate model for a strength-requiring cooperation tasks), but only prior knowledge as important for word learning (preferring the knowledgeable but not the strong model for word learning tasks). Young children’s selective model choice thus reveals an early rational competence: They infer characteristics from past behavior and flexibly consider what characteristics are relevant for certain tasks. PMID:27505043

  13. Choosing and using climate change scenarios for ecological-impact assessments and conservation decisions

    Science.gov (United States)

    Amy K. Snover,; Nathan J. Mantua,; Littell, Jeremy; Michael A. Alexander,; Michelle M. McClure,; Janet Nye,

    2013-01-01

    Increased concern over climate change is demonstrated by the many efforts to assess climate effects and develop adaptation strategies. Scientists, resource managers, and decision makers are increasingly expected to use climate information, but they struggle with its uncertainty. With the current proliferation of climate simulations and downscaling methods, scientifically credible strategies for selecting a subset for analysis and decision making are needed. Drawing on a rich literature in climate science and impact assessment and on experience working with natural resource scientists and decision makers, we devised guidelines for choosing climate-change scenarios for ecological impact assessment that recognize irreducible uncertainty in climate projections and address common misconceptions about this uncertainty. This approach involves identifying primary local climate drivers by climate sensitivity of the biological system of interest; determining appropriate sources of information for future changes in those drivers; considering how well processes controlling local climate are spatially resolved; and selecting scenarios based on considering observed emission trends, relative importance of natural climate variability, and risk tolerance and time horizon of the associated decision. The most appropriate scenarios for a particular analysis will not necessarily be the most appropriate for another due to differences in local climate drivers, biophysical linkages to climate, decision characteristics, and how well a model simulates the climate parameters and processes of interest. Given these complexities, we recommend interaction among climate scientists, natural and physical scientists, and decision makers throughout the process of choosing and using climate-change scenarios for ecological impact assessment.

  14. Selective Cooperation in Early Childhood - How to Choose Models and Partners.

    Science.gov (United States)

    Hermes, Jonas; Behne, Tanya; Studte, Kristin; Zeyen, Anna-Maria; Gräfenhain, Maria; Rakoczy, Hannes

    2016-01-01

    Cooperation is essential for human society, and children engage in cooperation from early on. It is unclear, however, how children select their partners for cooperation. We know that children choose selectively whom to learn from (e.g. preferring reliable over unreliable models) on a rational basis. The present study investigated whether children (and adults) also choose their cooperative partners selectively and what model characteristics they regard as important for cooperative partners and for informants about novel words. Three- and four-year-old children (N = 64) and adults (N = 14) saw contrasting pairs of models differing either in physical strength or in accuracy (in labeling known objects). Participants then performed different tasks (cooperative problem solving and word learning) requiring the choice of a partner or informant. Both children and adults chose their cooperative partners selectively. Moreover they showed the same pattern of selective model choice, regarding a wide range of model characteristics as important for cooperation (preferring both the strong and the accurate model for a strength-requiring cooperation tasks), but only prior knowledge as important for word learning (preferring the knowledgeable but not the strong model for word learning tasks). Young children's selective model choice thus reveals an early rational competence: They infer characteristics from past behavior and flexibly consider what characteristics are relevant for certain tasks. PMID:27505043

  15. Why do different people choose different university degrees? Motivation and the choice of degree

    Directory of Open Access Journals (Sweden)

    Anya eSkatova

    2014-11-01

    Full Text Available Different people choose which undergraduate degree to study at the university for different reasons. To date, there have been limited attempts to identify individual differences in motivation that drive the undergraduate degree choice. We identified that people choose university degrees for four reasons: career concerns (Career, intrinsic interest (Interest in the subject, an opportunity to help others (Helping and because they are looking for an easy option into higher education (Loafing. We investigated whether these motivation apply to the choice of undergraduate degree in two samples: (1 undergraduate (N = 989 and (2 prospective (N = 896 students. We developed the Motivations Influencing Course Choice (MICC questionnaire to measure these motivations. Scales of Helping, Career, Loafing and Interest showed good psychometric properties, showed validity with respect to general life goals and personality traits, and predicted actual and prospective degree choices. We demonstrated that medical degrees were chosen due to a mixture of Helping and Career, while engineering degrees were associated with Career and low interest in the degree. The choice of art and humanities degrees was driven by Interest and low concern about future career, accompanied with high Loafing. We also demonstrated gender differences: females were high in Helping (both samples and Interest (only in undergraduate sample motivation, while males scored higher in Career (only in undergraduate sample and Loafing (both samples. The findings can feed into both theoretical accounts of proximal motivation as well as help to improve degree programmes at universities and provide better career advice.

  16. Ventral and dorsal streams for choosing word order during sentence production.

    Science.gov (United States)

    Thothathiri, Malathi; Rattinger, Michelle

    2015-12-15

    Proficient language use requires speakers to vary word order and choose between different ways of expressing the same meaning. Prior statistical associations between individual verbs and different word orders are known to influence speakers' choices, but the underlying neural mechanisms are unknown. Here we show that distinct neural pathways are used for verbs with different statistical associations. We manipulated statistical experience by training participants in a language containing novel verbs and two alternative word orders (agent-before-patient, AP; patient-before-agent, PA). Some verbs appeared exclusively in AP, others exclusively in PA, and yet others in both orders. Subsequently, we used sparse sampling neuroimaging to examine the neural substrates as participants generated new sentences in the scanner. Behaviorally, participants showed an overall preference for AP order, but also increased PA order for verbs experienced in that order, reflecting statistical learning. Functional activation and connectivity analyses revealed distinct networks underlying the increased PA production. Verbs experienced in both orders during training preferentially recruited a ventral stream, indicating the use of conceptual processing for mapping meaning to word order. In contrast, verbs experienced solely in PA order recruited dorsal pathways, indicating the use of selective attention and sensorimotor integration for choosing words in the right order. These results show that the brain tracks the structural associations of individual verbs and that the same structural output may be achieved via ventral or dorsal streams, depending on the type of regularities in the input. PMID:26621706

  17. Brief Report: The Identity Style Inventory (ISI-3) and the Utrecht-Management of Identity Commitments Scale (U-MICS)--Factor Structure, Reliability, and Convergent Validity in French-Speaking University Students

    Science.gov (United States)

    Zimmermann, Gregoire; Mahaim, Elodie Biermann; Mantzouranis, Gregory; Genoud, Philippe A.; Crocetti, Elisabetta

    2012-01-01

    The purpose of this study was to evaluate the factor structure and the reliability of the French versions of the Identity Style Inventory (ISI-3) and the Utrecht-Management of Identity Commitments Scale (U-MICS) in a sample of college students (N = 457, 18-25 years old). Confirmatory factor analyses confirmed the hypothesized three-factor solution…

  18. El problema de las concepciones alternativas en la actualidad (parte III). Utilización didáctica de los errores conceptuales que aparecen en cómics, prensa, novelas y libros de texto

    OpenAIRE

    Carrascosa Alís, Jaime

    2006-01-01

    La existencia de graves errores conceptuales en artículos de prensa, novelas, cómics e incluso libros de texto está relacionada con el origen y persistencia de determinadas ideas alternativas. Cabe plantearse si no podrían utilizarse estos mismos medios para contribuir al tratamiento y el cambio de tales ideas.

  19. Multicenter study of isavuconazole MIC distributions and epidemiological cutoff values for the Cryptococcus neoformans-Cryptococcus gattii species complex using the CLSI M27-A3 broth microdilution method

    NARCIS (Netherlands)

    Espinel-Ingroff, A.; Chowdhary, A.; Gonzalez, G.M.; Guinea, J.; Hagen, F.; Meis, J.F.G.M.; Thompson, G.R.; Turnidge, J.

    2015-01-01

    Epidemiological cutoff values (ECVs) of isavuconazole are not available for Cryptococcus spp. The isavuconazole ECVs based on wild-type (WT) MIC distributions for 438 Cryptococcus neoformans nongenotyped isolates, 870 isolates of genotype VNI, and 406 Cryptococcus gattii isolates from six laboratori

  20. Laboratory investigation of the microbiologically influenced corrosion (MIC) resistance of a novel Cu-bearing 2205 duplex stainless steel in the presence of an aerobic marine Pseudomonas aeruginosa biofilm.

    Science.gov (United States)

    Xia, Jin; Yang, Chunguang; Xu, Dake; Sun, Da; Nan, Li; Sun, Ziqing; Li, Qi; Gu, Tingyue; Yang, Ke

    2015-01-01

    The microbiologically influenced corrosion (MIC) resistance of a novel Cu-bearing 2205 duplex stainless steel (2205 Cu-DSS) against an aerobic marine Pseudomonas aeruginosa biofilm was investigated. The electrochemical test results showed that Rp increased and icorr decreased sharply after long-term immersion in the inoculation medium, suggesting that 2205 Cu-DSS possessed excellent MIC resistance to the P. aeruginosa biofilm. Fluorescence microscope images showed that 2205 Cu-DSS possessed a strong antibacterial ability, and its antibacterial efficiency after one and seven days was 7.75% and 96.92%, respectively. The pit morphology comparison after 14 days between 2205 DSS and 2205 Cu-DSS demonstrated that the latter showed a considerably reduced maximum MIC pit depth compared with the former (1.44 μm vs 9.50 μm). The experimental results suggest that inhibition of the biofilm was caused by the copper ions released from the 2205 Cu-DSS, leading to its effective mitigation of MIC by P. aeruginosa. PMID:26194639

  1. Scenario analysis in business model choosing for instrument-making enterprise

    Directory of Open Access Journals (Sweden)

    Ye.V. Krykavskyi

    2014-06-01

    Full Text Available The aim of the article. The aim of this study is to develop the selection technology of the enterprise business model in conditions of market dynamism and uncertainty, as well as testing of this technology at a specific enterprise according to the method of situational analysis. The results of the analysis. Economic development of modern markets is characterized by the fact that almost all the enterprises experience significant dynamics and a high degree of entropy, which complicates the decision-making process. As the basic unit of the economy, the enterprise should respond correctly to new objective challenges, including: instability of global financial markets, business intellectualization and acceleration of scientific-technological progress with simultaneous strengthening of environmental demands to economic systems, increasing of competition and its transition to a global level, rapid change of consumer demands and individualization of consumer proposal, increased attention to corporate responsibility towards society and so on. Obviously, the important task of modern enterprises becomes a justification of business organization model, which is selected in accordance with the established potential and the aforementioned challenges. The authors have developed a selection technology of the enterprise business model, which involves the combination of scenarios use, strategic alternatives matrix, SWOT-analysis and the method of «decisions tree» during the implementation of the following steps: - generating of alternative scenarios of enterprise business models with the help of strategic alternatives matrix. Previously prepared analytical materials are used in the preparation of scenarios. Creating a scenario involves the following steps: determining a time interval formulation of the events, verbal interpretation of their essence, their quantitative assessment; - choosing the type of scenarios and scenarios selection criteria for business

  2. Sub-MICs of Mentha piperita essential oil and menthol inhibits AHL mediated quorum sensing and biofilm of Gram-negative bacteria.

    Science.gov (United States)

    Husain, Fohad M; Ahmad, Iqbal; Khan, Mohammad S; Ahmad, Ejaz; Tahseen, Qudisa; Khan, Mohd Shahnawaz; Alshabib, Nasser A

    2015-01-01

    Bacterial quorum sensing (QS) is a density dependent communication system that regulates the expression of certain genes including production of virulence factors in many pathogens. Bioactive plant extract/compounds inhibiting QS regulated gene expression may be a potential candidate as antipathogenic drug. In this study anti-QS activity of peppermint (Mentha piperita) oil was first tested using the Chromobacterium violaceum CVO26 biosensor. Further, the findings of the present investigation revealed that peppermint oil (PMO) at sub-Minimum Inhibitory Concentrations (sub-MICs) strongly interfered with acyl homoserine lactone (AHL) regulated virulence factors and biofilm formation in Pseudomonas aeruginosa and Aeromonas hydrophila. The result of molecular docking analysis attributed the QS inhibitory activity exhibited by PMO to menthol. Assessment of ability of menthol to interfere with QS systems of various Gram-negative pathogens comprising diverse AHL molecules revealed that it reduced the AHL dependent production of violacein, virulence factors, and biofilm formation indicating broad-spectrum anti-QS activity. Using two Escherichia coli biosensors, MG4/pKDT17 and pEAL08-2, we also confirmed that menthol inhibited both the las and pqs QS systems. Further, findings of the in vivo studies with menthol on nematode model Caenorhabditis elegans showed significantly enhanced survival of the nematode. Our data identified menthol as a novel broad spectrum QS inhibitor. PMID:26029178

  3. Increasing the impact of medical image computing using community-based open-access hackathons: The NA-MIC and 3D Slicer experience.

    Science.gov (United States)

    Kapur, Tina; Pieper, Steve; Fedorov, Andriy; Fillion-Robin, J-C; Halle, Michael; O'Donnell, Lauren; Lasso, Andras; Ungi, Tamas; Pinter, Csaba; Finet, Julien; Pujol, Sonia; Jagadeesan, Jayender; Tokuda, Junichi; Norton, Isaiah; Estepar, Raul San Jose; Gering, David; Aerts, Hugo J W L; Jakab, Marianna; Hata, Nobuhiko; Ibanez, Luiz; Blezek, Daniel; Miller, Jim; Aylward, Stephen; Grimson, W Eric L; Fichtinger, Gabor; Wells, William M; Lorensen, William E; Schroeder, Will; Kikinis, Ron

    2016-10-01

    The National Alliance for Medical Image Computing (NA-MIC) was launched in 2004 with the goal of investigating and developing an open source software infrastructure for the extraction of information and knowledge from medical images using computational methods. Several leading research and engineering groups participated in this effort that was funded by the US National Institutes of Health through a variety of infrastructure grants. This effort transformed 3D Slicer from an internal, Boston-based, academic research software application into a professionally maintained, robust, open source platform with an international leadership and developer and user communities. Critical improvements to the widely used underlying open source libraries and tools-VTK, ITK, CMake, CDash, DCMTK-were an additional consequence of this effort. This project has contributed to close to a thousand peer-reviewed publications and a growing portfolio of US and international funded efforts expanding the use of these tools in new medical computing applications every year. In this editorial, we discuss what we believe are gaps in the way medical image computing is pursued today; how a well-executed research platform can enable discovery, innovation and reproducible science ("Open Science"); and how our quest to build such a software platform has evolved into a productive and rewarding social engineering exercise in building an open-access community with a shared vision.

  4. Increasing the impact of medical image computing using community-based open-access hackathons: The NA-MIC and 3D Slicer experience.

    Science.gov (United States)

    Kapur, Tina; Pieper, Steve; Fedorov, Andriy; Fillion-Robin, J-C; Halle, Michael; O'Donnell, Lauren; Lasso, Andras; Ungi, Tamas; Pinter, Csaba; Finet, Julien; Pujol, Sonia; Jagadeesan, Jayender; Tokuda, Junichi; Norton, Isaiah; Estepar, Raul San Jose; Gering, David; Aerts, Hugo J W L; Jakab, Marianna; Hata, Nobuhiko; Ibanez, Luiz; Blezek, Daniel; Miller, Jim; Aylward, Stephen; Grimson, W Eric L; Fichtinger, Gabor; Wells, William M; Lorensen, William E; Schroeder, Will; Kikinis, Ron

    2016-10-01

    The National Alliance for Medical Image Computing (NA-MIC) was launched in 2004 with the goal of investigating and developing an open source software infrastructure for the extraction of information and knowledge from medical images using computational methods. Several leading research and engineering groups participated in this effort that was funded by the US National Institutes of Health through a variety of infrastructure grants. This effort transformed 3D Slicer from an internal, Boston-based, academic research software application into a professionally maintained, robust, open source platform with an international leadership and developer and user communities. Critical improvements to the widely used underlying open source libraries and tools-VTK, ITK, CMake, CDash, DCMTK-were an additional consequence of this effort. This project has contributed to close to a thousand peer-reviewed publications and a growing portfolio of US and international funded efforts expanding the use of these tools in new medical computing applications every year. In this editorial, we discuss what we believe are gaps in the way medical image computing is pursued today; how a well-executed research platform can enable discovery, innovation and reproducible science ("Open Science"); and how our quest to build such a software platform has evolved into a productive and rewarding social engineering exercise in building an open-access community with a shared vision. PMID:27498015

  5. Sub-MICs of Mentha piperita essential oil and menthol inhibits AHL mediated quorum sensing and biofilm of Gram negative bacteria

    Directory of Open Access Journals (Sweden)

    Fohad Mabood Husain

    2015-05-01

    Full Text Available Bacterial quorum sensing (QS is a density dependent communication system that regulates the expression of certain genes including production of virulence factors in many pathogens. Bioactive plant extract/compounds inhibiting QS regulated gene expression may be a potential candidate as antipathogenic drug. In this study anti-QS activity of peppermint (Mentha piperita oil was first tested using the Chromobacterium violaceum CVO26 biosensor. Further, the findings of the present investigation revealed that peppermint oil at sub-MICs strongly interfered with acyl homoserine lactone (AHL regulated virulence factors and biofilm formation in Pseudomonas aeruginosa and Aeromonas hydrophila. The result of molecular docking analysis attributed the quorum sensing inhibitory activity exhibited by peppermint oil to menthol. Assessment of ability of menthol to interfere with quorum sensing systems of various Gram-negative pathogens comprising diverse AHL molecules revealed that it reduced the AHL dependent production of violacein, virulence factors and biofilm formation indicating broad-spectrum anti-QS activity. Using two E. coli biosensors, MG4/pKDT17 and pEAL08-2, we also confirmed that menthol inhibited both the las and pqs quorum sensing systems. Further, findings of the in vivo studies with menthol on nematode model Caenorhabditis elegans showed significantly enhanced survival of the nematode. Our data identified menthol as a novel broad spectrum quorum sensing inhibitor.

  6. Sub-MICs of Mentha piperita essential oil and menthol inhibits AHL mediated quorum sensing and biofilm of Gram-negative bacteria.

    Science.gov (United States)

    Husain, Fohad M; Ahmad, Iqbal; Khan, Mohammad S; Ahmad, Ejaz; Tahseen, Qudisa; Khan, Mohd Shahnawaz; Alshabib, Nasser A

    2015-01-01

    Bacterial quorum sensing (QS) is a density dependent communication system that regulates the expression of certain genes including production of virulence factors in many pathogens. Bioactive plant extract/compounds inhibiting QS regulated gene expression may be a potential candidate as antipathogenic drug. In this study anti-QS activity of peppermint (Mentha piperita) oil was first tested using the Chromobacterium violaceum CVO26 biosensor. Further, the findings of the present investigation revealed that peppermint oil (PMO) at sub-Minimum Inhibitory Concentrations (sub-MICs) strongly interfered with acyl homoserine lactone (AHL) regulated virulence factors and biofilm formation in Pseudomonas aeruginosa and Aeromonas hydrophila. The result of molecular docking analysis attributed the QS inhibitory activity exhibited by PMO to menthol. Assessment of ability of menthol to interfere with QS systems of various Gram-negative pathogens comprising diverse AHL molecules revealed that it reduced the AHL dependent production of violacein, virulence factors, and biofilm formation indicating broad-spectrum anti-QS activity. Using two Escherichia coli biosensors, MG4/pKDT17 and pEAL08-2, we also confirmed that menthol inhibited both the las and pqs QS systems. Further, findings of the in vivo studies with menthol on nematode model Caenorhabditis elegans showed significantly enhanced survival of the nematode. Our data identified menthol as a novel broad spectrum QS inhibitor.

  7. Mic Check/Reality Check

    Directory of Open Access Journals (Sweden)

    Wanda Vrasti

    2012-03-01

    Full Text Available Over the past couple of months history has been unfolding with dizzying speed. The #occupy model of leaderless, demandless direct action, which in the beginning no one with only a slim understanding of how capitalism works thought could become anything more than a facile if charming jab at anti-corporate activism, has gone viral. Every morning we wake up to new reports about ‘occupying X’, where X can be anything from cities, campuses, boardrooms, buildings, highways, and public events, all the way to academic disciplines. What originally seemed like a romantic fantasy about temporary autonomous zones now feels like history. And no one likes to find themselves on thewrong side of history, especially not intellectuals, let alone intellectuals in the business of explaining global politics.

  8. mic porno gay

    OpenAIRE

    Salvador, Antonio

    2011-01-01

    Si la historieta pornográfica ha sido, durante años, marginada por los eruditos, la pornografía gay ha sufrido una marginación aún mayor de la que, no obstante, va saliendo desde hace algunos años. En las siguientes páginas se ofrece un selección bibliográfica comentada tanto de historietas como de obras teóricas con la intención de orientar a quienes tengan interés en iniciarse en el estudio de dicho tema..

  9. Image Specificity

    OpenAIRE

    Jas, Mainak; Parikh, Devi

    2015-01-01

    For some images, descriptions written by multiple people are consistent with each other. But for other images, descriptions across people vary considerably. In other words, some images are specific $-$ they elicit consistent descriptions from different people $-$ while other images are ambiguous. Applications involving images and text can benefit from an understanding of which images are specific and which ones are ambiguous. For instance, consider text-based image retrieval. If a query descr...

  10. Choosing between rocks, hard places and a lot more. The economic interface

    International Nuclear Information System (INIS)

    decisions: for deciding whether or not to explore or develop, for choosing between exploration prospects ('rocks') in a licensing round, for choosing between basins or countries ('places') in which one wants to explore and produce, and for choosing between development concepts, recovery mechanisms, plateau rates, ... (and a lot more), in field development planning. Due to the largely unpredictable nature of the subsurface and the future oil price, the concepts of 'risk' (=possibility of a financial loss or an unachieved objective) and unfortunately, to a lesser extent 'grisk' (possibility of a financial gain in excess of the objective) are quite central in the oil business. Illustrations of 'risk' and 'grisk' will be presented. 24 refs

  11. Specifics of fashion marketing and its impact on consumer's behaviour

    OpenAIRE

    Kureková, Sylvia

    2013-01-01

    This thesis deals with the characteristics of fashion marketing, its specifics and its impact on consumer's behaviour. It defines the specifics of fashion marketing and communication strategies of the fashion companies and its impact on consumer's behaviour focusing on two specific companies: H&M and Zara. This thesis explains how fashion marketing differs from other industries and what factors influence its consumers to choose the product. It analyzes the marketing tools and instruments whic...

  12. Children choose their own stories: the impact of choice on children's learning of new narrative skills.

    Science.gov (United States)

    Khan, Kiren; Nelson, Keith; Whyte, Elisabeth

    2014-07-01

    Despite evidence that early narrative abilities are predictive of literacy skills and academic achievement, only limited progress has been made in understanding how the development of these narrative skills can be facilitated. The current study measured the effectiveness of a new narrative intervention conducted with 26 preschoolers. Children were assigned to one of two intervention conditions: an active-choice condition (able to choose story components) or a no-choice condition (story components were preselected). Both groups otherwise received the same explicit and engaging teaching of story grammar. As predicted, greater narrative skill gains were evident for the active-choice intervention; including larger gains on both central story grammar components and story information overall. Future implications for how stories might be presented to young children in order to more richly facilitate narrative skill acquisition are discussed. PMID:23725564

  13. Choosing the Optimal Spatial Domain Measure of Enhancement for Mammogram Images

    Directory of Open Access Journals (Sweden)

    Karen Panetta

    2014-01-01

    Full Text Available Medical imaging systems often require image enhancement, such as improving the image contrast, to provide medical professionals with the best visual image quality. This helps in anomaly detection and diagnosis. Most enhancement algorithms are iterative processes that require many parameters be selected. Poor or nonoptimal parameter selection can have a negative effect on the enhancement process. In this paper, a quantitative metric for measuring the image quality is used to select the optimal operating parameters for the enhancement algorithms. A variety of measures evaluating the quality of an image enhancement will be presented along with each measure’s basis for analysis, namely, on image content and image attributes. We also provide guidelines for systematically choosing the proper measure of image quality for medical images.

  14. Maximizing the Value of Photovoltaic Installations on Schools in California: Choosing the Best Electricity Rates

    Energy Technology Data Exchange (ETDEWEB)

    Ong, S.; Denholm, P.

    2011-07-01

    Schools in California often have a choice between multiple electricity rate options. For schools with photovoltaic (PV) installations, choosing the right rate is essential to maximize the value of PV generation. The rate option that minimizes a school?s electricity expenses often does not remain the most economical choice after the school installs a PV system. The complex interaction between PV generation, building load, and rate structure makes determining the best rate a challenging task. This report evaluates 22 rate structures across three of California?s largest electric utilities--Pacific Gas and Electric Co. (PG&E), Southern California Edison (SCE), and San Diego Gas and Electric (SDG&E)--in order to identify common rate structure attributes that are favorable to PV installations.

  15. Analysis and design of a web-based decision support system for choosing higher education studies

    Directory of Open Access Journals (Sweden)

    Kostoglou Vassilis

    2014-01-01

    Full Text Available The vocational orientation of the youngsters who are about to enter, study, or have recently graduated at higher education (HE institutions, and linking HE with labor market are two research areas which have not been investigated extensively in Balkan countries. Job (or occupational profiles, among other tools used in vocational orientation, provide standardized and digitized descriptions of different professions. This article focuses on the analysis and the design of a web-based decision support system (DSS to assist its users in getting thoroughly informed about HE studies in Greece, and eventually in choosing their vocational prospects. Apart from reviewing the related previous research work and relevant web-based systems, we present the main elements of the system’s analysis and its design, the extensions that could lead to even more powerful systems, and conclusions about the advantages, limitations and practical application of the DSS.

  16. How do defendants choose their trial court? Evidence for a heuristic processing account

    Directory of Open Access Journals (Sweden)

    Mandeep K. Dhami

    2013-09-01

    Full Text Available In jurisdictions with two or more tiers of criminal courts, some defendants can choose the type of trial court to be tried in. This may involve a trade-off between the probability of acquittal/conviction and the estimated severity of sentence if convicted. For instance, in England and Wales, the lower courts have a higher conviction rate but limited sentencing powers, whereas the higher courts have a higher acquittal rate but greater sentencing powers. We examined 255 offenders' choice of trial court type using a hypothetical scenario where innocence and guilt was manipulated. Participants' choices were better predicted by a lexicographic than utility maximization model. A greater proportion of ``guilty'' participants chose the lower court compared to their ``innocent'' counterparts, and estimated sentence length was more important to the former than latter group. The present findings provide further support for heuristic decision-making in the criminal justice domain, and have implications for legal policy-making.

  17. Opting in and Creating Demand: Why Young People Choose to Teach Mathematics to Each Other

    Science.gov (United States)

    Tucker-Raymond, Eli; Lewis, Naama; Moses, Maisha; Milner, Chad

    2016-08-01

    Access to science, technology, engineering, and mathematics fields serves as a key entry point to economic mobility and civic enfranchisement. Such access must take seriously the intellectual power of the knowledge and practices of non-dominant youth. In our case, this has meant to shift epistemic authority in mathematics from academic institutions to young people themselves. This article is about why high school-aged students, from underrepresented groups, choose to participate in an out-of-school time program in which they teach younger children in the domains of mathematics and computer science. It argues for programmatic principles based on access, identity engagement, relationship building, and connections to community to support underrepresented youth as learners, teachers, leaders, and organizers in mathematics-related activities using game design as the focus of activity.

  18. Refined Method for Choosing a Security Solution for Mobile Application – Web Service Interactions

    Directory of Open Access Journals (Sweden)

    Silvia Trif

    2011-12-01

    Full Text Available This paper aims to present a refined algorithm for choosing the appropriate security implementation for mobile applications connecting to web services. Common security scenarios are presented. Each scenario has several characteristics associated. The correlations between these security scenarios characteristics are computed and selected only the characteristics that are less correlated. The proposed algorithm inventories the available scenarios, inventories the requirements and selects the security scenario that match. A case study applies the proposed method to a situation where a WP7 application and a WCF service are interacting. Security scenarios for WCF services and their characteristics are described. Application security requirements are established. A security solution is proposed based on the results of the proposed method.

  19. Description of women's personality traits and psychological vulnerability prior to choosing hormone replacement therapy

    DEFF Research Database (Denmark)

    Loekkegaard, E; Eplov, L F; Køster, A;

    2002-01-01

    INTRODUCTION: Data suggest that women using hormone replacement therapy (HRT) represent a special subgroup of the general population regarding, for instance, cardiovascular risk factors and education. OBJECTIVE: To analyse if women who choose HRT are characterised a priori by high neuroticism score...... or by psychological vulnerability. DESIGN: A prospective population-based study was initiated in 1976 with follow-ups in 1981, 1987 and 1996. The population comprises a random sample of 621 women born in 1936 and living in the county of Copenhagen. STUDY METHODS: The analyses are based on data on two sub...... included Eysencks personality questionnaire concerning intro/extroversion and neuroticism. At the age of 45, the re-examination of the women included a test for psychological vulnerability. The participants reported whether or not they used HRT at the age of 40, 45, 51 and 60 years. The analyses comprised...

  20. Live as we choose: The role of autonomy support in facilitating intrinsic motivation.

    Science.gov (United States)

    Meng, Liang; Ma, Qingguo

    2015-12-01

    According to Self-determination Theory (SDT), autonomy is a basic psychological need, satisfaction of which may lead to enhanced intrinsic motivation and related beneficial outcomes. By manipulating the opportunity to choose between tasks of equal difficulty, throughout the motivational process, the effect of autonomy support was examined both behaviorally and electrophysiologically. More negative stimulus-preceding negativity (SPN) and an enlarged FRN loss-win difference wave (d-FRN) indicated an enhanced expectation toward the positive outcome (during the anticipation stage) as well as intensified intrinsic motivation toward the task (during the outcome appraisal stage) when choice was available. Taken together, results of the present study suggest d-FRN upon feedback as a real-time electrophysiological indicator of intrinsic/autonomous motivation and illustrate the important role of autonomy-supportive job design in the workplace. PMID:26344180

  1. A THEORETICAL ANALYSIS OF KEY POINTS WHEN CHOOSING OPEN SOURCE ERP SYSTEMS

    Directory of Open Access Journals (Sweden)

    Fernando Gustavo Dos Santos Gripe

    2011-08-01

    Full Text Available The present work is aimed at presenting a theoretical analysis of the main features of Open Source ERP systems, herein identified as success technical factors, in order to contribute to the establishment of parameters to be used in decision-making processes when choosing a system which fulfills the organization´s needs. Initially, the life cycle of ERP systems is contextualized, highlighting the features of Open Source ERP systems. As a result, it was verified that, when carefully analyzed, these systems need further attention regarding issues of project continuity and maturity, structure, transparency, updating frequency, and support, all of which are inherent to the reality of this type of software. Nevertheless, advantages were observed in what concerns flexibility, costs, and non-discontinuity as benefits. The main goal is to broaden the discussion about the adoption of Open Source ERP systems.

  2. ["Choosing wisely" in infectious diseases : Overuse of antibiotics - too few vaccinations].

    Science.gov (United States)

    Jung, N; Koop, H; Riessen, R; Galle, J-C; Jany, B; Märker-Herrmann, E

    2016-06-01

    The "choosing wisely" recommendations of the German Society of Internal Medicine (DGIM) and its specialist societies address diagnostic and therapeutic procedures, which are of particular medical importance but applied too often or too rarely in clinical practice. The aim is to further improve treatment of patients. Important topics of overuse and insufficient treatment related to the diagnostics, therapy, prevention and exclusion of infectious diseases could be identified. These topics not only play an important role in the discipline of infectious diseases but are also relevant for other internal medical disciplines. These topics related to infectious diseases have also been integrated into the recommendations of the German Society of Gastroenterology, Digestive and Metabolic Diseases as well as the German Societies for Internal Intensive Care and Emergency Medicine, for Pneumology, for Nephrology and for Rheumatology. The pivotal issues of the recommendations are the inappropriate use of antibiotics and insufficient vaccination rates.

  3. A new method for choosing parameters in delay reconstruction-based forecast strategies

    CERN Document Server

    Garland, Joshua; Bradley, Elizabeth

    2015-01-01

    Delay-coordinate reconstruction is a proven modeling strategy for building effective forecasts of nonlinear time series. The first step in this process is the estimation of good values for two parameters, the time delay and the reconstruction dimension. Many heuristics and strategies have been proposed in the literature for estimating these values. Few, if any, of these methods were developed with forecasting in mind, however, and their results are not optimal for that purpose. Even so, these heuristics -- intended for other applications -- are routinely used when building delay coordinate reconstruction-based forecast models. In this paper, we propose a general framework for choosing optimal parameter values for forecast methods that are based on delay-coordinate reconstructions. The basic calculation involves maximizing the shared information between each delay vector and the future state of the system. We illustrate the effectiveness of this method on several synthetic and experimental systems, showing tha...

  4. RELATIONSHIP AMONG CORPORATE IMAGE, INTANGIBLE PERCEIVED QUALITY, CHOOSING, HABIT AND CUSTOMER LOYALTY

    Directory of Open Access Journals (Sweden)

    Maryam REHMAN

    2012-01-01

    Full Text Available This study explores relationships among Corporate Image, Intangible Perceived Quality, Choosing, Habit and Customer Loyalty and investigates the pivotal role these variables play in establishing and maintaining healthy base of loyal customers. Data were collected from Pakistani bank account holders and the empirical findings showed that corporate image plays the most important role in establishing and maintaining customer loyalty in the markets. Organizations always look forward to long lasting success. In order to be successful in the long run, they need to keep abreast with all of their stakeholders. Out of the stakeholders, customers are considered to be the most important one. Customer Loyalty is a psychological motive which today’s managers are considerate about. This study concludes that long-term success and sustainable reputation of an organization depends on customer loyalty.

  5. Realism and instrumentalism about the wave function. How should we choose?

    CERN Document Server

    Dorato, Mauro

    2014-01-01

    The main claim of the paper is that one can be 'realist' (in some sense) about quantum mechanics without requiring any form of realism about the wave function. We begin by discussing various forms of realism about the wave function, namely Albert's configuration-space realism, Duerr Zanghi and Goldstein's nomological realism about the wave function, Esfeld's dispositional reading of the wave function and Pusey Barrett and Rudolph's realism about the quantum state. By discussing the articulation of these four positions, and their interrelation, we conclude that instrumentalism about the wave function is by itself not sufficient to choose one over the other interpretations of quantum mechanics, thereby confirming in a different way the indetermination of the metaphysical interpretations of quantum mechanics.

  6. Reasons for mini-implants failure: choosing installation site should be valued!

    Directory of Open Access Journals (Sweden)

    Alberto Consolaro

    2014-04-01

    Full Text Available Mini-implant loss is often associated with physical and mechanical aspects that result from choosing an inappropriate placement site. It is worth highlighting that: a Interdental alveolar bone crests are flexible and deformable. For this reason, they may not offer the ideal absolute anchorage. The more cervical the structures, the more delicate they are, thus offering less physical support for mini-implant placement; b Alveolar bone crests of triangular shape are more deformable, whereas those of rectangular shape are more flexible; c The bases of the alveolar processes of the maxilla and the mandible are not flexible, for this reason, they are more likely to receive mini-implants; d The more cervical a mini-implant is placed, the higher the risk of loss; the more apical a mini-implant is placed, the better its prognosis will be; e 3D evaluations play a major role in planning the use of mini-implants. Based on the aforementioned considerations, the hypotheses about mini-implant loss are as follows: 1 Deflection of maxillary and mandibular alveolar processes when mini-implants are more cervically placed; 2 Mini-implants placed too near the periodontal ligament, with normal intra-alveolar tooth movement; 3 Low bone density, low thickness and low alveolar bone volume; 4 Low alveolar cortical bone thickness; 5 Excessive pressure inducing trabecular bone microfracture; 6 Sites of higher anatomical weakness in the mandible and the maxilla; 7 Thicker gingival tissue not considered when choosing the mini-implant.

  7. Religious freedom and family life: reflections on the right to choose.

    Science.gov (United States)

    Paltrow, L M

    1985-01-01

    Family integrity, family life and family privacy, and parental authority are the arguments used to convince legislators to pass parental consent and notification laws and judges to uphold them. Those who favor these laws argue that the government is interfering with family life and undermining parental authority when it permits minors to get abortions without parental consent or notification. It is time to challenge the family integrity argument. Too often the notion is accepted that abortion is unique in the sense that it is unlike all other constitutionally protected rights. Imagine a 16-year-old girl who lives in a rigidly orthodox Catholic family who is never encouraged to read and think, even about religious laws. One day she discovers that that she is pregnant. This young woman thinks of her dreams of the future and her ability to care for and raise a child. Ultimately, she decides to have an abortion. She finds a local doctor and clinic and has an abortion without her parents' knowledge or consent. Carol Gilligan, in her book, "In a Different Voice," examines the psychological development of women. Her studies reveal that, for women, decisions about pregnancy are among the most significant in providing opportunities for moral development, personal growth, and the separation from family that achieving adulthood requires. Yet, some would deny women that opportunity to make these decisions by requiring parental consent or notice. The right to choose abortion is not all that different from other constitutionally protected individual rights. Both free speech and the right to choose provide unequalled opportunities for people to become responsible, thinking citizens. Possibly abortion is not unique, since many decisions affect and involve other's lives. What is unique is that moral reasoning is not attributed to young women who must make choices about pregnancy.

  8. Choosing to biopsy or refer suspicious melanocytic lesions in general practice

    Directory of Open Access Journals (Sweden)

    Robison Sean

    2012-08-01

    Full Text Available Abstract Background General practitioners (GPs are involved in the management of most melanocytic skin lesions in Australia. A high quality biopsy technique is a crucial first step in management, as it is recognized that poor techniques can mislead, delay, or miss a diagnosis of melanoma. There has been little published on the biopsy decisions and techniques of GPs. This study aims to describe the current management choices made by GPs for suspicious melanocytic skin lesions and to compare their choices with the best practice guidelines. Methods An anonymous survey of GPs presented with three clinical scenarios with increasing complexity of melanoma in which a referral or biopsy decision was specified. Results 391 mailed surveys with a 76.3% response rate. Mean biopsy experience was 4.14 biopsies per GP per month. The rates of choosing to refer among the three scenarios were 31%, 52% and 81% respectively, with referral to surgery being the most common choice (81%. Most biopsy techniques (55% were chosen according to best practice guidelines, although non-guideline biopsy techniques chosen included shave (n = 10, punch biopsy (n = 57, wide excisions (n = 65, and flaps (n = 10. The few GPs (n = 5 who identified themselves as skin specialist GPs were no more likely to adhere to guidelines than their colleagues. Conclusion A majority of referrals and biopsies were chosen by GPs according to best practice guidelines, but concern remains for the high proportion of GPs making non-guideline based choices. How GPs choose to biopsy or refer needs further training, audit, and research if Australia is to improve the outcome of melanoma management in general practice.

  9. La industria del cómic en España: radiografía de ¿un mito o una realidad?

    Directory of Open Access Journals (Sweden)

    Pons, Álvaro M.

    2011-09-01

    Full Text Available In spite of the importance of figures referred to published titles, or number of copies printed, which help to set publishing strategies and to really know the comic situation in Spain, there are no liable data. We are giving in this article, some enlightening data along with some explanations related to the evolution of the market from 2001 to 2009. The different titles are grouped considering the place they come from (Europe, Asia, United States…, along with their format (album, book, magazine, comic-book…. Using all this information, we can deduce evolution lines, tendencies, futures perspectives in an industry that, despite its precariousness, is facing an increasing number of copies sold and a progressive settlement in the Spanish publishing world.

    A pesar de la importancia que revestiría para establecer estrategias editoriales y para un mejor conocimiento de la situación del cómic en España, no existen cifras fiables sobre títulos publicados y cifras de tiradas. En este artículo se proporcionan algunos datos aclaradores al respecto. Se ofrece una evolución de nuestro mercado desde 2001 a 2009. Se agrupan los diversos títulos por lugar de procedencia (Europa, Asia, Estados Unidos…, así como por formatos (álbum, libro, revista, comic-book…. De todo ello se desprenden líneas evolutivas, tendencias y perspectivas de futuro de una industria que, a pesar de su precariedad, conoce un aumento de las ventas y un progresivo asentamiento en el panorama de la edición española.

  10. Antimicrobial evaluation of new metallic complexes with xylitol active against P. aeruginosa and C. albicans: MIC determination, post-agent effect and Zn-uptake.

    Science.gov (United States)

    Santi, E; Facchin, G; Faccio, R; Barroso, R P; Costa-Filho, A J; Borthagaray, G; Torre, M H

    2016-02-01

    Xylitol (xylH5) is metabolized via the pentose pathway in humans, but it is unsuitable as an energy source for many microorganisms where it produces a xylitol-induced growth inhibition and disturbance in protein synthesis. For this reason, xylitol is used in the prophylaxis of several infections. In the search of better antimicrobial agents, new copper and zinc complexes with xylitol were synthesized and characterized by analytical and spectrosco pic methods: Na2[Cu3(xylH−4)2]·NaCl·4.5H2O (Cu-xyl) and [Zn4(xylH−4)2(H2O)2]·NaCl·3H2O (Zn-xyl). Both copper and zinc complexes presented higher MIC against Pseudomona aeruginosa than the free xylitol while two different behaviors were found against Candida albicans depending on the complex. The growth curves showed that Cu-xyl presented lower activity than the free ligand during all the studied period. In the case of Znxyl the growth curves showed that the inhibition of the microorganism growth in the first stage was equivalent to that of xylitol but in the second stage (after 18 h) Zn-xyl inhibited more. Besides, the PAE (post agent effect)obtained for Zn-xyl and xyl showed that the recovery from the damage of microbial cells had a delay of 14 and 13 h respectively. This behavior could be useful in prophylaxis treatments for infectious diseases where it is important that the antimicrobial effect lasts longer. With the aim to understand the microbiological activities the analysis of the particle size, lipophilicity and Zn uptake was performed. PMID:26619097

  11. Tariff-Specific Preferences and Their Influence on Price Sensitivity

    Directory of Open Access Journals (Sweden)

    Agnieszka Wolk

    2010-05-01

    Full Text Available For many services, consumers can choose among a range of optional tariffs that differ in their access and usage prices. Recent studies indicate that tariff-specific preferences may lead consumers to choose a tariff that does not minimize their expected billing rate. This study analyzes how tariff-specific preferences influence the responsiveness of consumers’ usage and tariff choice to changes in price. We show that consumer heterogeneity in tariff-specific preferences leads to heterogeneity in their sensitivity to price changes. Specifically, consumers with tariff-specific preferences are less sensitive to price increases of their preferred tariff than other consumers. Our results provide an additional reason why firms should offer multiple tariffs rather than a uniform nonlinear pricing plan to extract maximum consumer surplus.

  12. Technical specification for vacuum systems

    International Nuclear Information System (INIS)

    The vacuum systems at the Stanford Linear Accelerator Center (SLAC) are primarily of all-metal construction and operate at pressures from 10-5 to 10-11 Torr. The primary gas loads during operation result from thermal desorption and beam-induced desorption from the vacuum chamber walls. These desorption rates can be extremely high in the case of hydrocarbons and other contaminants. These specifications place a major emphasis on eliminating contamination sources. The specifications and procedures have been written to insure the cleanliness and vacuum integrity of all SLAC vacuum systems, and to assist personnel involved with SLAC vacuum systems in choosing and designing components that are compatible with existing systems and meet the quality and reliability of SLAC vacuum standards. The specification includes requirements on design, procurement, fabrication, chemical cleaning, clean room practices, welding and brazing, helium leak testing, residual gas analyzer testing, bakeout, venting, and pumpdown. Also appended are specifications regarding acceptable vendors, isopropyl alcohol, bakeable valve cleaning procedure, mechanical engineering safety inspection, notes on synchrotron radiation, and specifications of numerous individual components

  13. Technical specification for vacuum systems

    Energy Technology Data Exchange (ETDEWEB)

    Khaw, J. (ed.)

    1987-01-01

    The vacuum systems at the Stanford Linear Accelerator Center (SLAC) are primarily of all-metal construction and operate at pressures from 10/sup -5/ to 10/sup -11/ Torr. The primary gas loads during operation result from thermal desorption and beam-induced desorption from the vacuum chamber walls. These desorption rates can be extremely high in the case of hydrocarbons and other contaminants. These specifications place a major emphasis on eliminating contamination sources. The specifications and procedures have been written to insure the cleanliness and vacuum integrity of all SLAC vacuum systems, and to assist personnel involved with SLAC vacuum systems in choosing and designing components that are compatible with existing systems and meet the quality and reliability of SLAC vacuum standards. The specification includes requirements on design, procurement, fabrication, chemical cleaning, clean room practices, welding and brazing, helium leak testing, residual gas analyzer testing, bakeout, venting, and pumpdown. Also appended are specifications regarding acceptable vendors, isopropyl alcohol, bakeable valve cleaning procedure, mechanical engineering safety inspection, notes on synchrotron radiation, and specifications of numerous individual components. (LEW)

  14. Simultaneous Assessment of Acidogenesis-Mitigation and Specific Bacterial Growth-Inhibition by Dentifrices.

    Directory of Open Access Journals (Sweden)

    Sarah Forbes

    Full Text Available Dentifrices can augment oral hygiene by inactivating bacteria and at sub-lethal concentrations may affect bacterial metabolism, potentially inhibiting acidogenesis, the main cause of caries. Reported herein is the development of a rapid method to simultaneously measure group-specific bactericidal and acidogenesis-mitigation effects of dentifrices on oral bacteria. Saliva was incubated aerobically and anaerobically in Tryptone Soya Broth, Wilkins-Chalgren Broth with mucin, or artificial saliva and was exposed to dentifrices containing triclosan/copolymer (TD; sodium fluoride (FD; stannous fluoride and zinc lactate (SFD1; or stannous fluoride, zinc lactate and stannous chloride (SFD2. Minimum inhibitory concentrations (MIC were determined turbidometrically whilst group-specific minimum bactericidal concentrations (MBC were assessed using growth media and conditions selective for total aerobes, total anaerobes, streptococci and Gram-negative anaerobes. Minimum acid neutralization concentration (MNC was defined as the lowest concentration of dentifrice at which acidification was inhibited. Differences between MIC and MNC were calculated and normalized with respect to MIC to derive the combined inhibitory and neutralizing capacity (CINC, a cumulative measure of acidogenesis-mitigation and growth inhibition. The overall rank order for growth inhibition potency (MIC under aerobic and anaerobic conditions was: TD> SFD2> SFD1> FD. Acidogenesis-mitigation (MNC was ordered; TD> FD> SFD2> SFD1. CINC was ordered TD> FD> SFD2> SFD1 aerobically and TD> FD> SFD1> SFD2 anaerobically. With respect to group-specific bactericidal activity, TD generally exhibited the greatest potency, particularly against total aerobes, total anaerobes and streptococci. This approach enables the rapid simultaneous evaluation of acidity mitigation, growth inhibition and specific antimicrobial activity by dentifrices.

  15. THE ROLE AND THE IMPORTANCE IN CHOOSING THE PROPER MANAGERIAL ACCOUNTING CONCEPTS REGARDING THE NEED FOR INFORMATION ON THE DECISION MAKING FACTORS WITHIN THE COMPANIES

    Directory of Open Access Journals (Sweden)

    Delia David

    2014-09-01

    Full Text Available Both the theory and modern practice of the management accounting took over two general concepts regarding its organizational process, structuring accounting in either an integrated system or a dualist one. We aim at emphasizing the characteristics, the role and the importance of these concepts in regards to the calculation process and the accounting entries of the costs generated by economic entities with an eye at gaining profit. Choosing one of the previously mentioned concepts must be done taking into consideration the specific of the company in question as well as the information necessary to the manager who needs to find out the optimum solution in order to achieve the rehabilitation and efficiency of the activity which is supposed to be carried out. The subject of this work is approached both theoretically and practically, relying on the following research methods: the comparison method, the observation method and the case study method.

  16. Different condylar displacements between centric relation and maximum intercuspation before and after orthodontic intervention%正畸干预前后 MIC-CR 位髁突位移变化

    Institute of Scientific and Technical Information of China (English)

    韩旭; 邵玉婷; 孙钦凤; 郭泾

    2015-01-01

    Objective To investigate the effects of orthodontic intervention on maximum intercuspation (MIC)-centric relation (CR)condylar displacement of patients with or without temporomandibular disorders (TMD).Methods A total of 31 orthodontic patients aged 16 to 45 years were selected and divided into the TMD group (n =15)and non-TMD group (n =16).Records of MIC and CR of these patients taken before and after orthodontic intervention were compared.Results The two groups had different MIC-CR displacement before and after treatment.There were more changes in the TMD group,and the changes were mostly favorable.The MIC-CR condylar displacement was correlated with the symptom checklist (SCL)score.Conclusion Orthodontic intervention has effect on condylar position of pa-tients,especially for those with TMD.Orthodontists,therefore,need to understand and pay attention to the effect of malocclusion on TMD and limitations of measurement of condylar displacement (MCD)in the diagnosis.%目的:旨在探讨正畸干预对最大牙尖交错位(MIC)-正中关系位(CR)髁突位移量的影响。方法选取16~45岁门诊正畸患者31例,其中非颞下颌关节紊乱病(TMD)组16例(NTMD 组),TMD 组15例,在正畸干预前后分别取 MIC 与 CR 位记录。分析两组患者正畸干预前后正中牙合位与正中关系位的髁突位置差异。结果正畸干预前 TMD 组与 NTMD 组 MIC-CR 之间髁突位移(MCD)量存在差异,正畸干预后两组 MIC-CR 位移量减小,TMD组较为显著,且多为有利变化,TMD 组正畸干预前后 MIC-CR 髁突位移量与 TMD 症状自评量表得分呈相关性。结论正畸干预在一定程度上对错牙合畸形患者的髁突位置产生影响,对于 TMD 患者尤甚。因此,正畸医生要认识并注意到错牙合畸形对 TMD 产生和发展的作用,并正确认识 MCD 在诊断中的局限性。

  17. The Relationship between Attitudes toward Participation in Physical Activities and Motives for Choosing Teaching Physical Education as a Career

    Directory of Open Access Journals (Sweden)

    Nasser Al-Rawahi

    2013-07-01

    Full Text Available This study aims at investigating the relationship between physical education teachers’ attitudes toward participation in physical activity and their motives toward choosing physical education as a teaching profession. Two questionnaires with a sample of 98 participants were employed as a data collection vehicle. The results showed that participants in this study had strong attitudes toward physical activities. Furthermore, participants expressed a mixture of intrinsic and extrinsic reasons as to why they opted for physical education as a teaching profession. Moreover, the findings revealed a significant relationship between participants' attitudes toward participation in physical activity and their motives toward choosing physical education as a teaching profession.

  18. Incorporação ao solo de substrato contendo micélio e conídios de Pochonia chlamydosporia para o manejo de Meloidogyne javanica

    Directory of Open Access Journals (Sweden)

    Rosangela Dallemole-Giaretta

    2014-04-01

    Full Text Available Os clamidósporos são os principais propágulos utilizados como fonte de inóculo de Pochonia chlamydosporia em experimentos envolvendo o biocontrole do nematoide das galhas. O presente trabalho teve por objetivo avaliar o controle de Meloidogyne javanica em tomateiro por meio da aplicação ao solo de grãos de arroz colonizados pelo fungo contendo apenas micélio e conídio, sem a presença de clamidósporos. O isolado de P. chlamydosporia Pc-10 foi cultivado por 15 dias a 26°C em arroz previamente esterilizado em forno microondas. Dois experimentos foram conduzidos simultaneamente em casa de vegetação. No experimento 1, vasos de 2L de capacidade foram preenchidos com mistura solo:areia (1:1, v:v, contendo 3g kg-1 de solo de grãos de arroz colonizados pelo antagonista. No experimento 2, o fungo foi adicionado ao solo de vasos de 0,5L nas doses de 1, 5, 10, 15, 20, 25 ou 30g kg-1 de solo. Em seguida, o substrato de cada vaso foi infestado com 4.000 ovos de M. javanica e, após 15 dias, uma plântula de tomate foi transplantada. No experimento 1, a aplicação do fungo ao solo reduziu o número de galhas e de ovos do nematoide em 40% e 72,83%, respectivamente. No experimento 2, houve redução do número de ovos a partir de doses de 5g kg 1 de solo e no número de galhas, principalmente, nas doses de 25 e 30g kg-1 de solo. Conclui-se que P. chlamydosporia Pc-10 controlou M. javanica em tomateiro, mesmo quando aplicado ao solo na forma de grãos de arroz colonizados e sem a presença de clamidósporos.

  19. African primary care research: Choosing a topic and developing a proposal

    Directory of Open Access Journals (Sweden)

    Bob Mash

    2014-01-01

    Full Text Available This is the first in a series of articles on primary care research in the African context. The aim of the series is to help build capacity for primary care research amongst the emerging departments of family medicine and primary care on the continent. Many of the departments are developing Masters of Medicine programmes in Family Medicine and their students will all be required to complete research studies as part of their degree. This series is being written with this audience in particular in mind – both the students who must conceptualise and implement a research project as well as their supervisors who must assist them.This article gives an overview of the African primary care context, followed by a typology of primary care research. The article then goes on to assist the reader with choosing a topic and defining their research question. Finally the article addresses the structure and contents of a  research proposal and the ethical issues that should be considered.

  20. Choosing a genome browser for a Model Organism Database: surveying the maize community.

    Science.gov (United States)

    Sen, Taner Z; Harper, Lisa C; Schaeffer, Mary L; Andorf, Carson M; Seigfried, Trent E; Campbell, Darwin A; Lawrence, Carolyn J

    2010-01-01

    As the B73 maize genome sequencing project neared completion, MaizeGDB began to integrate a graphical genome browser with its existing web interface and database. To ensure that maize researchers would optimally benefit from the potential addition of a genome browser to the existing MaizeGDB resource, personnel at MaizeGDB surveyed researchers' needs. Collected data indicate that existing genome browsers for maize were inadequate and suggest implementation of a browser with quick interface and intuitive tools would meet most researchers' needs. Here, we document the survey's outcomes, review functionalities of available genome browser software platforms and offer our rationale for choosing the GBrowse software suite for MaizeGDB. Because the genome as represented within the MaizeGDB Genome Browser is tied to detailed phenotypic data, molecular marker information, available stocks, etc., the MaizeGDB Genome Browser represents a novel mechanism by which the researchers can leverage maize sequence information toward crop improvement directly. Database URL: http://gbrowse.maizegdb.org/

  1. Why do males choose heterospecific females in the red spider mite?

    Science.gov (United States)

    Sato, Yukie; Staudacher, Heike; Sabelis, Maurice W

    2016-01-01

    In some species, males readily show courtship behaviour towards heterospecific females and even prefer them to females of their own species. This behaviour is generally explained by indiscriminate mating to acquire more mates, but may partly be explained by male mate preference mechanisms that have developed to choose among conspecific females, as male preference for larger females causes mating with larger heterospecific females. Recently, we found that males of the red spider mite, Tetranychus evansi collected from Spain (invasive population), prefer to mate with females of the two-spotted spider mite, T. urticae rather than with conspecific females. In spider mites, mate preference for non-kin individuals has been observed. Here, we investigated if T. evansi males collected from the area of its origin (Brazil) also show preference for heterospecific females. Secondly, we investigated if mate preference of T. evansi males for heterospecific females is affected by their relatedness to conspecific females which are offered together with heterospecific females. We found that mate preference for heterospecific females exists in Brazilian T. evansi, suggesting that the preference for heterospecific females is not a lack of evolved premating isolation with an allopatric species. We found that T. evansi males showed lower propensity to mate with heterospecific females when alternative females were non-kin in the two iso-female lines collected from Brazil. However, the effect of relatedness on male mate preference was not significant. We discuss alternative hypotheses explaining why T. evansi males prefer to mate with T. urticae females. PMID:26530994

  2. Who's choosing whom? A sociological study of the specialty choices in a Danish context

    Directory of Open Access Journals (Sweden)

    Pernille Dehn

    2011-04-01

    Full Text Available Objectives: The purpose of this study was to investigate if habitus, the unconscious and embodied mental structures founded early in life, can contribute to our understanding of how individuals choose a medical specialty. Methods: A qualitative approach was employed using standardized open-ended interviews. In the present research, sampling was purposive, with an aim to illuminating the study objective. A sample of six juniors and three senior doctors were recruited from gynecology and obstetrics, vascular surgery and general practice via a snowball method. The interview guide and the subsequent analysis were based on Bourdieu's sociological theory. Results: Three central themes emerged, labeled as "the use of distinctions and dichotomies", "the shaping of habitus" and "consequences of the shaping of habitus". These represent values and preferences developed through childhood education and experiences which may contribute to explaining specialty choices. Participants distinguished between specialties by referring to dichotomous characteristics of the specialty (such as sick/healthy patients; young/elderly patients; fine/coarse surgery. Conclusions: Bourdieu's theory is useful for broadening our understanding of specialty choice, as his central concept, habitus, was found to direct the choice of specialty and constrain the number of possible specialties for the individual doctor. Research is needed to better understand how various factors affect the specialty choices of medical school graduates.

  3. Ethical dilemmas in choosing a healthful diet: vote with your fork!

    Science.gov (United States)

    Nestle, M

    2000-11-01

    Dietary guidelines for health promotion and disease prevention in the USA recommend a consumption pattern based largely on grains, fruit and vegetables, with smaller amounts of meat and dairy foods, and even smaller amounts of foods high in fat and sugar. Such diets are demonstrably health promoting, but following them raises ethical issues related to the role of nutritionists in advising the public about healthful dietary choices, as well as to the role of the food industry in food production and marketing. In the USA a shift towards a more plant-based diet would affect the economic interests of producers of food commodities, food products and meals prepared outside the home; it would also affect the environment, food prices, trade with other countries (developing as well as industrialized) and relationships among the food industry, government agencies (domestic and international) and food and nutrition professionals. In a free-market economy any dietary choice has consequences for food producers. Thus, considerations of ethical dilemmas in choosing healthful diets suggest that food choices are political acts that offer opportunities for all parties concerned to examine the consequences of such choices and 'vote with forks'. PMID:11115798

  4. Personal values Involved in choosing a College: Analysis Using the Means-End Chain Approach

    Directory of Open Access Journals (Sweden)

    Lílian Carolina Viana

    2014-04-01

    Full Text Available The investigation the reasons for choice of products and services by consumers stands out as relevant in the area of ​​market studies, as well as notes management for any organization. Through the Theory of Means-End Chain proposed by Gutman (1982, which relates the “means” (attributes and benefits linked to the consumption of products or services with the “ends” in terms of personal values achieved, it is possible understand of the meanings that consumers attribute the choice of products and services in a more abstract level. Thus, the objective of this study is to understand what aspects, considering attributes, consequences and personal values ​​guide the behavior of students in choosing the nursing course at a private institution of higher education. Based on the theory mentioned it was adopted the technique laddering, in-depth interview and analysis methodology and representation of the hierarchical value map, which was interpreted and analyzed in order to understand the cognitive structure of students’ choice.The analysis of the results indicate that students are guided primarily by hedonistic values of happiness itself the choice of nursing in college studied.

  5. LEARNING TO CHOOSE AMONG SOCIAL FORAGING STRATEGIES IN ADULT HOUSE SPARROWS (Passer domesticus).

    Science.gov (United States)

    Belmaker, Amos; Motro, Uzi; Feldman, Marcus W; Lotem, Arnon

    2012-11-01

    Social foragers may be regarded as being engaged in a producer-scrounger game in which they can search for food independently or join others who have discovered food. Research on the producer-scrounger game has focused mainly on the different factors influencing its ESS solution, but very little is known about the actual mechanisms that shape players' decisions. Recent work has shown that early experience can affect producer-scrounger foraging tendencies in young house sparrows, and that in nutmeg mannikins learning is involved in reaching the ESS. Here we show that direct manipulation of the success rate experienced by adult sparrows when following others can change their strategy choice on the following day. We presented to live sparrows an experimental regime, where stuffed adult house sparrows in a feeding position were positioned on a foraging grid that included two reward regimes: a positive one, in which the stuffed models were placed near food, and a negative one, in which the models were placed away from food. There was a significant increase in joining behavior after the positive treatment (exhibited by 84% of the birds), but no change after the negative treatment. Further analysis demonstrated that sparrows more frequently used the strategy with which they were more successful (usually joining), and that differences in strategy use were correlated with differences in success. These results suggest that adult birds can monitor their success and learn to choose among social foraging strategies in the producer-scrounger game. PMID:23226911

  6. Do female Nicrophorus vespilloides reduce direct costs by choosing males that mate less frequently?

    Science.gov (United States)

    Mazué, G. P. F.; Carter, M. J.; Head, M. L.; Moore, A. J.; Royle, N. J.

    2016-01-01

    Sexual conflict occurs when selection to maximize fitness in one sex does so at the expense of the other sex. In the burying beetle Nicrophorus vespilloides, repeated mating provides assurance of paternity at a direct cost to female reproductive productivity. To reduce this cost, females could choose males with low repeated mating rates or smaller, servile males. We tested this by offering females a dichotomous choice between males from lines selected for high or low mating rate. Each female was then allocated her preferred or non-preferred male to breed. Females showed no preference for males based on whether they came from lines selected for high or low mating rates. Pairs containing males from high mating rate lines copulated more often than those with low line males but there was a negative relationship between female size and number of times she mated with a non-preferred male. When females bred with their preferred male the number of offspring reared increased with female size but there was no such increase when breeding with non-preferred males. Females thus benefited from being choosy, but this was not directly attributable to avoidance of costly male repeated mating. PMID:26979560

  7. Identifying existing Choosing Wisely recommendations of high relevance and importance to hematology.

    Science.gov (United States)

    Hicks, Lisa K; Rajasekhar, Anita; Bering, Harriet; Carson, Kenneth R; Kleinerman, Judith; Kukreti, Vishal; Ma, Alice; Mueller, Brigitta U; O'Brien, Sarah H; Panepinto, Julie A; Pasquini, Marcelo C; Sarode, Ravi; Wood, William A

    2016-08-01

    Choosing Wisely (CW) is a medical stewardship initiative led by the American Board of Internal Medicine Foundation in collaboration with professional medical societies in the United States. In an effort to learn from and leverage the work of others, the American Society of Hematology CW Task Force developed a method to identify and prioritize CW recommendations from other medical societies of high relevance and importance to patients with blood disorders and their physicians. All 380 CW recommendations were reviewed and assessed for relevance and importance. Relevance was assessed using the MORE(TM) relevance scale. Importance was assessed with regard to six guiding principles: harm avoidance, evidence, aggregate cost, relevance, frequency and impact. Harm avoidance was considered the most important principle. Ten highly relevant and important recommendations were identified from a variety of professional societies. Recommendations focused on decreasing unnecessary imaging, blood work, treatments and transfusions, as well as on increasing collaboration across disciplines and considering value when recommending treatments. Many CW recommendations have relevance beyond the society of origin. The methods developed by the ASH CW Task Force could be easily adapted by other Societies to identify additional CW recommendations of relevance and importance to their fields. Am. J. Hematol. 91:787-792, 2016. © 2016 Wiley Periodicals, Inc. PMID:27152483

  8. Choosing processor array configuration by performance modeling for a highly parallel linear algebra algorithm

    Energy Technology Data Exchange (ETDEWEB)

    Littlefield, R.J.; Maschhoff, K.J.

    1991-04-01

    Many linear algebra algorithms utilize an array of processors across which matrices are distributed. Given a particular matrix size and a maximum number of processors, what configuration of processors, i.e., what size and shape array, will execute the fastest The answer to this question depends on tradeoffs between load balancing, communication startup and transfer costs, and computational overhead. In this paper we analyze in detail one algorithm: the blocked factored Jacobi method for solving dense eigensystems. A performance model is developed to predict execution time as a function of the processor array and matrix sizes, plus the basic computation and communication speeds of the underlying computer system. In experiments on a large hypercube (up to 512 processors), this model has been found to be highly accurate (mean error {approximately} 2%) over a wide range of matrix sizes (10 {times} 10 through 200 {times} 200) and processor counts (1 to 512). The model reveals, and direct experiment confirms, that the tradeoffs mentioned above can be surprisingly complex and counterintuitive. We propose decision procedures based directly on the performance model to choose configurations for fastest execution. The model-based decision procedures are compared to a heuristic strategy and shown to be significantly better. 7 refs., 8 figs., 1 tab.

  9. Identifying & Classification of Criteria in Choosing a Bank By Customers: Case Study at Bank Mellat

    Directory of Open Access Journals (Sweden)

    Mohammad Ali Haghighi

    2013-09-01

    Full Text Available Abstract: in order to attract the customers, it’s really needed to consider the elements they take in to account in evaluating a company. New banks attempts in stealing the customers from the experienced bank especially in retail banks prove the importance of such topic. The main purpose of this research is to identify the criteria by which a customer chooses a bank in retail banking in competitive market. Doing so, 166 evaluating criteria were extracted using field study, interviews with 43customers, back office and front office in several banks. After reconsidering the criteria by the experts, they were reduced to 50 elements and distributed as a pre-test among 60 customers. After validity and reliability test by "Stage random sampling" and "Cochran method" 669 samples were obtained. 678 questionnaires were confirmed out of 810. In order to identify and analyze these factors, by "factor analysis method", 45 questions were remained, The identified factors are as follows: Employees and trust, Quality and ease of service, Up to date technology and techniques, Physical appearance, Variety of services, investment , credits and loan, cost, reputation, convenience, incentives. Among these factors, employee and trust by 13,317 percent of variance were recognized as most important ones.

  10. Choosing between an apple and a chocolate bar: the impact of health and taste labels.

    Directory of Open Access Journals (Sweden)

    Suzanna E Forwood

    Full Text Available Increasing the consumption of fruit and vegetables is a central component of improving population health. Reasons people give for choosing one food over another suggest health is of lower importance than taste. This study assesses the impact of using a simple descriptive label to highlight the taste as opposed to the health value of fruit on the likelihood of its selection. Participants (N=439 were randomly allocated to one of five groups that varied in the label added to an apple: apple; healthy apple; succulent apple; healthy and succulent apple; succulent and healthy apple. The primary outcome measure was selection of either an apple or a chocolate bar as a dessert. Measures of the perceived qualities of the apple (taste, health, value, quality, satiety and of participant characteristics (restraint, belief that tasty foods are unhealthy, BMI were also taken. When compared with apple selection without any descriptor (50%, the labels combining both health and taste descriptors significantly increased selection of the apple ('healthy & succulent' 65.9% and 'succulent & healthy' 62.4%, while the use of a single descriptor had no impact on the rate of apple selection ('healthy' 50.5% and 'succulent' 52%. The strongest predictors of individual dessert choice were the taste score given to the apple, and the lack of belief that healthy foods are not tasty. Interventions that emphasize the taste attributes of healthier foods are likely to be more effective at achieving healthier diets than those emphasizing health alone.

  11. Australia is 'free to choose' economic growth and falling environmental pressures.

    Science.gov (United States)

    Hatfield-Dodds, Steve; Schandl, Heinz; Adams, Philip D; Baynes, Timothy M; Brinsmead, Thomas S; Bryan, Brett A; Chiew, Francis H S; Graham, Paul W; Grundy, Mike; Harwood, Tom; McCallum, Rebecca; McCrea, Rod; McKellar, Lisa E; Newth, David; Nolan, Martin; Prosser, Ian; Wonhas, Alex

    2015-11-01

    Over two centuries of economic growth have put undeniable pressure on the ecological systems that underpin human well-being. While it is agreed that these pressures are increasing, views divide on how they may be alleviated. Some suggest technological advances will automatically keep us from transgressing key environmental thresholds; others that policy reform can reconcile economic and ecological goals; while a third school argues that only a fundamental shift in societal values can keep human demands within the Earth's ecological limits. Here we use novel integrated analysis of the energy-water-food nexus, rural land use (including biodiversity), material flows and climate change to explore whether mounting ecological pressures in Australia can be reversed, while the population grows and living standards improve. We show that, in the right circumstances, economic and environmental outcomes can be decoupled. Although economic growth is strong across all scenarios, environmental performance varies widely: pressures are projected to more than double, stabilize or fall markedly by 2050. However, we find no evidence that decoupling will occur automatically. Nor do we find that a shift in societal values is required. Rather, extensions of current policies that mobilize technology and incentivize reduced pressure account for the majority of differences in environmental performance. Our results show that Australia can make great progress towards sustainable prosperity, if it chooses to do so.

  12. African primary care research: choosing a topic and developing a proposal.

    Science.gov (United States)

    Mash, Bob

    2014-02-06

    This is the first in a series of articles on primary care research in the African context. The aim of the series is to help build capacity for primary care research amongst the emerging departments of family medicine and primary care on the continent. Many of the departments are developing Masters of Medicine programmes in Family Medicine and their students will all be required to complete research studies as part of their degree. This series is being written with this audience in particular in mind--both the students who must conceptualise and implement a research project as well as their supervisors who must assist them.This article gives an overview of the African primary care context, followed by a typology of primary care research. The article then goes on to assist the reader with choosing a topic and defining their research question. Finally the article addresses the structure and contents of a research proposal and the ethical issues that should be considered.

  13. Why do males choose heterospecific females in the red spider mite?

    Science.gov (United States)

    Sato, Yukie; Staudacher, Heike; Sabelis, Maurice W

    2016-01-01

    In some species, males readily show courtship behaviour towards heterospecific females and even prefer them to females of their own species. This behaviour is generally explained by indiscriminate mating to acquire more mates, but may partly be explained by male mate preference mechanisms that have developed to choose among conspecific females, as male preference for larger females causes mating with larger heterospecific females. Recently, we found that males of the red spider mite, Tetranychus evansi collected from Spain (invasive population), prefer to mate with females of the two-spotted spider mite, T. urticae rather than with conspecific females. In spider mites, mate preference for non-kin individuals has been observed. Here, we investigated if T. evansi males collected from the area of its origin (Brazil) also show preference for heterospecific females. Secondly, we investigated if mate preference of T. evansi males for heterospecific females is affected by their relatedness to conspecific females which are offered together with heterospecific females. We found that mate preference for heterospecific females exists in Brazilian T. evansi, suggesting that the preference for heterospecific females is not a lack of evolved premating isolation with an allopatric species. We found that T. evansi males showed lower propensity to mate with heterospecific females when alternative females were non-kin in the two iso-female lines collected from Brazil. However, the effect of relatedness on male mate preference was not significant. We discuss alternative hypotheses explaining why T. evansi males prefer to mate with T. urticae females.

  14. Choosing fitness-enhancing innovations can be detrimental under fluctuating environments.

    Directory of Open Access Journals (Sweden)

    Julian Z Xue

    Full Text Available The ability to predict the consequences of one's behavior in a particular environment is a mechanism for adaptation. In the absence of any cost to this activity, we might expect agents to choose behaviors that maximize their fitness, an example of directed innovation. This is in contrast to blind mutation, where the probability of becoming a new genotype is independent of the fitness of the new genotypes. Here, we show that under environments punctuated by rapid reversals, a system with both genetic and cultural inheritance should not always maximize fitness through directed innovation. This is because populations highly accurate at selecting the fittest innovations tend to over-fit the environment during its stable phase, to the point that a rapid environmental reversal can cause extinction. A less accurate population, on the other hand, can track long term trends in environmental change, keeping closer to the time-average of the environment. We use both analytical and agent-based models to explore when this mechanism is expected to occur.

  15. Choosing between two semi-finalists: On academic performance gap, sex category, and decision question.

    Science.gov (United States)

    Foschi, Martha; Valenzuela, Jerilee

    2015-11-01

    We use an application-files experimental design to investigate a new topic in the assessment of candidates for junior-engineering jobs. Our focus is on two semi-finalists, a man and a woman, who show clearly different but still good levels of academic record. We keep the gap between those levels constant, but vary the sex category of the better performer. We also include control conditions in which the two have similar records. Each assessor's task was to choose either one applicant or neither, and to rate both in competence and suitability. The control-group competence ratings indicate no gender bias by either men or women; the experimental-conditions competence data are consistent with the candidates' records as predicted, but also show women minimizing the record of the better-performing male candidate. Choice and suitability, on the other hand, reveal a preference for the female applicant across respondents and conditions, as anticipated given the more open nature of those two questions, while still reflecting the academic records. Findings and their interpretation are presented in detail.

  16. A Decision Support System to Choose Optimal Release Cycle Length in Incremental Software Development Environments

    Directory of Open Access Journals (Sweden)

    Avnish Chandra Suman

    2016-09-01

    Full Text Available In the last few years it has been seen that many software vendors have started delivering projects incrementally with very short release cycles. Best examples of success of this approach has been Ubuntu Operating system that has a 6 months release cycle and popular web browsers such as Google Chrome, Opera, Mozilla Firefox. However there is very little knowledge available to the project managers to validate the chosen release cycle length. We propose a decision support system that helps to validate and estimate release cycle length in the early development phase by assuming that release cycle length is directly affected by three factors, (i choosing right requirements for current cycle, (ii estimating proximal time for each requirement, (iii requirement wise feedback from last iteration based on product reception, model accuracy and failed requirements. We have altered and used the EVOLVE technique proposed by G. Ruhe to select best requirements for current cycle and map it to time domain using UCP (Use Case Points based estimation and feedback factors. The model has been evaluated on both in-house as well as industry projects.

  17. Electronic Spatial Assistance for People with Dementia: Choosing the Right Device

    Directory of Open Access Journals (Sweden)

    Cornelia Schneider

    2014-06-01

    Full Text Available The demographic change and ageing in Europe will lead to a growing number of people suffering from dementia. Consequently, costs for public health will increase because people become more and more reliant on care and gradually lose their independence and mobility. In the case of dementia, remedial measures could be provided by assistive technology to support independent living at home for as long as possible. Current assistance systems are often limited to actively raising an alert (i.e., electronic panic buttons or location tracking. Due to this small range of functions these systems are poorly accepted by the target group. Thus, this paper reports on a selection process for a spatial data collection device allowing the development of a new so-called mobility safeguarding assistance system for people with dementia which combines features of different systems. In particular, the wearability as an everyday object is a key issue when it comes to identifying an adequate gadget for elderly people. The proposed methodology considers user requirements as well as technical requirements when it comes to finding a suitable device. Based on these requirements, several different devices were reviewed and tested in order to find most suitable potential device as part of the selection process. The device selected shows that the proposed process on how to choose the right device performed well.

  18. What Would Women Choose When Given a Choice in Breast Reconstruction?

    Science.gov (United States)

    Winch, Caleb J.

    2016-01-01

    Background: Reconstruction after mastectomy is an important milestone for many women treated for breast cancer. However, because many surgeons only offer their preferred method of reconstruction, it is not clear which approach women would choose if offered a genuine choice. Methods: Between 1998 and 2010, the breast reconstruction service at a major Australian teaching hospital was staffed by a single plastic surgeon trained in both prosthetic and autologous breast reconstruction techniques. The choices of all 837 women who underwent reconstruction were compared across time for publicly and privately funded patients using binary logistic regression. Results: Overall, women chose prosthetic over autologous reconstruction at a ratio of 4.7:1. This ratio increasingly favored prosthetic reconstruction over time, though less strongly for private patients who did not face a 3-year waiting list for autologous reconstruction. Conclusions: Financial constraints affected these women’s reconstruction choices. Nevertheless, and in contrast to the situation in the United States, these women clearly favored prosthetic over autologous reconstruction.

  19. African primary care research: choosing a topic and developing a proposal.

    Science.gov (United States)

    Mash, Bob

    2014-01-01

    This is the first in a series of articles on primary care research in the African context. The aim of the series is to help build capacity for primary care research amongst the emerging departments of family medicine and primary care on the continent. Many of the departments are developing Masters of Medicine programmes in Family Medicine and their students will all be required to complete research studies as part of their degree. This series is being written with this audience in particular in mind--both the students who must conceptualise and implement a research project as well as their supervisors who must assist them.This article gives an overview of the African primary care context, followed by a typology of primary care research. The article then goes on to assist the reader with choosing a topic and defining their research question. Finally the article addresses the structure and contents of a research proposal and the ethical issues that should be considered. PMID:26245432

  20. Impact of the Choosing the Best Program in Communities Committed to Abstinence Education

    Directory of Open Access Journals (Sweden)

    Lisa Lieberman

    2012-01-01

    Full Text Available States vary in standards for sex education, some requiring an emphasis on abstinence. Schools seek to identify curricula that reflect local community values and meet state standards. Choosing the Best (CTB, a classroom-based abstinence education curriculum, has been implemented in 75 Georgia school districts since 1995. CTB Inc., sought to determine if this popular program had an impact on abstinence attitudes, intentions, and behavior. Six Georgia public schools (1,143 ninth graders participated in the study in 2009-2010. Four randomly assigned schools received the CTB curriculum, taught by trained CTB staff. Two control schools received their usual textbook-based abstinence lessons. Surveys were conducted at the beginning and end of 9th grade, and the beginning of 10th grade. Data demonstrated significant impact of CTB at the end of 9th grade on commitment to abstinence, proabstinence beliefs and attitudes, intentions to maintain abstinence, and lower onset of sexual intercourse, and at the beginning of 10th grade on proabstinence attitudes. In two communities that sought an abstinence education approach, CTB had a short-term impact on abstinence attitudes, commitment, and behaviors, and a longer term impact on abstinence attitudes only.

  1. The Input-output Status and Farmers’Willingness to Choose Ecological Operation of Hickory

    Institute of Scientific and Technical Information of China (English)

    LIU Qiang; LI Shi-yong; WU Wei-guang

    2012-01-01

    This study takes Lin’an City which early carries out the experiment of ecological operation of hickory as the study site.On the basis of the input-output data on hickory and farmers’ land,we analyze the input-output status of hickory land which practises ecological operation,the operators’ willingness to accept ecological operation and the influencing factors.The results show that in the short term,ecological operation of hickory will have a certain negative impact on the economic benefits;within the experimental area,the degree of operators’ willingness to accept ecological operation of hickory is high,and the operators have a clear understanding of long-term comprehensive benefits which may be brought by ecological operation;the ecological experiment and demonstration of hickory have achieved certain results;family income level,characteristics of householders,education and training,and so on,are the main factors that affect the operators’ willingness to choose ecological operation.Finally,for how to further improve the promotion efficiency of ecological operation of hickory,we put forth some constructive recommendations.

  2. A study among dental students regarding the factors influenced dental students to choose dentistry as career

    Directory of Open Access Journals (Sweden)

    Gobichetti Palayam Jagatheeswaran AnbuSelvan

    2013-01-01

    Full Text Available Introduction: Career choice is a complex decision for students since it determines the kind of profession that they intend to pursue in life. As students try to make a career choice while in secondary school, they face the problem of matching their career choices with their abilities and school performance. Aims: The purpose of this study was to examine factors influencing career choice among dental college students in private dental collages in Tamil Nadu, India. Settings and Design: The study was conducted using descriptive survey design with a population of 989 students. The data for this study was collected using a questionnaire and interview schedules. Materials and Methods: The data for this study was collected using questionnaire previously used by Swati Shah and Rajaraman and interview schedules. The analysis of the study was based on the factors: Outcome expectations, gender, personal interests, and other factors. Results and Conclusion: The most common reason for among the dental students to choose dental science as their career choice was self-interested followed by didn′t get medicine degree, prestige and gives respect. The least common reasons observed in the study population were inspired by dentists. The findings of this study indicate that availability the most influential factors affecting career choices among students.

  3. Choosing a Single Sign-On Solution at STScI

    Science.gov (United States)

    Alexov, A.; Deighton, D.; Doggett, J.; McCuen, L.; Russell, R.; Yermolaev, A.

    2014-05-01

    The Space Telescope Science Institute (STScI) has over 100 online tools and services most of which require their own username and password for authentication. These services span from Human Resources tools for time-keeping to science collaborative wikis like Confluence and the Archive Search Services which give access to proprietary data. These disparate and independent systems have led to problems for end-users who must track multiple electronic identities for all these services. In order to consolidate these logins, improve security at STScI and to better the user experience, we have embarked on a search for a Single Sign-On (SSO) solution which would encompass a large number of requirements from engineering, science and IT divisions. In this paper we discuss several SSO options which we found to be popular with astronomical centers. We give full details on the reasoning behind choosing Shibboleth and Central Authentication Service (CAS) as our SSO solution at STScI. We outline hurdles, lessons learned and implementation solutions which we have taken in order to migrate STScI web services to using SSO. We discuss the benefits of SSO and our future plans.

  4. A predator from East Africa that chooses malaria vectors as preferred prey.

    Directory of Open Access Journals (Sweden)

    Ximena J Nelson

    Full Text Available BACKGROUND: All vectors of human malaria, a disease responsible for more than one million deaths per year, are female mosquitoes from the genus Anopheles. Evarcha culicivora is an East African jumping spider (Salticidae that feeds indirectly on vertebrate blood by selecting blood-carrying female mosquitoes as preferred prey. METHODOLOGY/PRINCIPAL FINDINGS: By testing with motionless lures made from mounting dead insects in lifelike posture on cork discs, we show that E. culicivora selects Anopheles mosquitoes in preference to other mosquitoes and that this predator can identify Anopheles by static appearance alone. Tests using active (grooming virtual mosquitoes rendered in 3-D animation show that Anopheles' characteristic resting posture is an important prey-choice cue for E. culicivora. Expression of the spider's preference for Anopheles varies with the spider's size, varies with its prior feeding condition and is independent of the spider gaining a blood meal. CONCLUSIONS/SIGNIFICANCE: This is the first experimental study to show that a predator of any type actively chooses Anopheles as preferred prey, suggesting that specialized predators having a role in the biological control of disease vectors is a realistic possibility.

  5. HRT Specification

    CERN Document Server

    Möller, M

    1996-01-01

    In the context of the AIS Project (Advanced Informatics Systems for administration and management) a study has been conducted that resulted in the definition of a high level information systems model. Thirteen proposed systems were defined for detailed analysis. The Finance, Foundation, Human Resources, Logistics and Purchasing areas have been studied in detail. These studies have lead to the purchase and implementation of the ORIAC and SIRIAC packages, the Foundation database, the Oracle HR package, the Triton package and EDH and BHT. This specification describes the Human Resources Toolkit (HRT) intended to be used for accessing data in the HR and Foundation systems. This toolkit should help the divisions carry out their Human Resource management, planning and follow-up. It will have extensive report generation capabilities and offer a variety of standard graphs. It should have an easy-to-use graphical user interface and run on the CERN standard desktop platforms.

  6. PRESENTING CLINICAL-PHARMACOLOGY AND THERAPEUTICS - EVALUATION OF A PROBLEM-BASED APPROACH FOR CHOOSING DRUG TREATMENTS

    NARCIS (Netherlands)

    DEVRIES, TPGM

    1993-01-01

    Between 1983 and 1989 three studies were conducted to determine whether the ability of senior medical students to choose drug treatments rationally had improved. This period spanned the implementation of a course in pharmacotherapeutics which trained students to use a systematic problem-based approa

  7. 20 CFR 10.316 - After selecting a treating physician, may an employee choose to be treated by another physician...

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false After selecting a treating physician, may an employee choose to be treated by another physician instead? 10.316 Section 10.316 Employees' Benefits... Benefits Medical Treatment and Related Issues § 10.316 After selecting a treating physician, may...

  8. How to Choose Grammatical Forms in Communication——A reading response of Larsen-Freeman’s Grammar of Choice

    Institute of Scientific and Technical Information of China (English)

    余静

    2014-01-01

    <正>While some believe that speakers choose certain grammar structures is to keep pace with the meaning they want to express,Larsen-Freeman holds the view that it is not the only intention.In fact,speakers face socially or discursively motivated grammatical choice even when the expressions stay the same meaning.This

  9. Why Choose Teaching? an International Review of Empirical Studies Exploring Student Teachers' Career Motivations and Levels of Commitment to Teaching

    Science.gov (United States)

    Heinz, Manuela

    2015-01-01

    Why do individuals all over the world choose to become school teachers? What motivates them to become educators of young people, and how committed are they to this cause when they enter their teacher education courses? Considering that teacher motivation and commitment have been identified as crucial factors for the future success of education and…

  10. Assignment Choice, Effort, and Assignment Completion: Does Work Ethic Predict Those Who Choose Higher-Effort Assignments?

    Science.gov (United States)

    Parkhurst, John T.; Fleisher, Matthew S.; Skinner, Christopher H.; Woehr, David J.; Hawthorn-Embree, Meredith L.

    2011-01-01

    After completing the Multidimensional Work-Ethic Profile (MWEP), 98 college students were given a 20-problem math computation assignment and instructed to stop working on the assignment after completing 10 problems. Next, they were allowed to choose to finish either the partially completed assignment that had 10 problems remaining or a new…

  11. 万古霉素MIC值与MRSA菌血症患者病死率的关系%Relationship of vancomycin MIC and mortality in patients with MRSA bacteremia

    Institute of Scientific and Technical Information of China (English)

    尉景娟; 丁秀荣; 马立艳; 孙伟

    2015-01-01

    Objective To study the relationship of vancomycin MIC in the range of sensitive and mortality in patients with MRSA bactere-mia,and to provide the reference of drug use to treat MRSA bacteraemia for clinicians. Methods All patients with an Staphylococcus aureus bloodstream infection who were hospitalized in our hospital in China from January 2011 to June 2014 were included into this study. Stain identifica-tion and antimicrobial susceptibilities of Staphylococcus aureus and MRSA were determined using VITEK-II automatic microbial analysis system. Results There was no significant difference in attributable mortality or 30-day mortality among high-MIC group( MIC=2 μg/ml),middle-MIC group(MIC=1 μg/ml)and low-MIC group(MIC≤0. 5 μg/ml). By Logistic regression analysis,renal insufficiency and pneumonia were found to be associated with attributable 30-day mortality. Conclusion Our study suggests that a high vancomycin MIC in a range are not associ-ated with mortality,but patients with renal insufficiency and patients with pneumonia are predictors of all-cause 30-day mortality.%目的:研究在敏感范围内的万古霉素最低抑菌浓度( MIC)值与金黄色葡萄球菌菌血症患者病死率的关系,为临床医生用药提供参考。方法收集2011年1月至2014年6月分离自住院患者血培养阳性的金黄色葡萄球菌,对金黄色葡萄球菌及耐甲氧西林金黄色葡萄球菌( MRSA)用VITEK-II全自动微生物分析系统进行鉴定及药敏检测,并对患者的临床资料进行回顾性分析。结果根据万古霉素MIC值为2μg/ml、1μg/ml和≤0.5μg/ml将患者分为高MIC组、中MIC组和低MIC组,金黄色葡萄球菌相关病死率在三组中无显著差异,MRSA相关病死率在三组中也无显著差异。逻辑回归分析结果显示,出现肾功能不全或肺炎对金黄色葡萄球菌菌血症及MRSA菌血症患者的病死率的影响有统计学意义。结论在敏感范围内万

  12. Gender Associated with the Intention to Choose a Medical Specialty in Medical Students: A Cross-Sectional Study in 11 Countries in Latin America

    Science.gov (United States)

    Mayta-Tristán, Percy; Pereyra-Elías, Reneé; Montenegro-Idrogo, Juan José; Inga-Berrospi, Fiorella; Ancalli, Felix; Bonilla-Escobar, Francisco; Diaz-Velez, Cristian; Gutierrez-Quezada, Erick; Gomez-Alhach, Jennifer; Muñoz-Medina, Carlos E.; Sanchez-Pozo, Adriana; Vidal, Milisen

    2016-01-01

    Introduction The selection of a medical specialty has been associated with multiple factors, such as personal preferences, academic exposure, motivational factors and sociodemographic factors, such as gender. The number of women in the medical field has increased in recent years. In Latin America, we have not found any studies that explore this relationship. Objective To determine whether there is an association between gender and the intention to choose a medical specialty in medical students from 11 countries in Latin America. Methods Secondary analysis of the Collaborative Working Group for the Research of Human Resources for Health (Red-LIRHUS) data; a multi-country project of students in their first year and fifth year of study, from 63 medical schools in 11 Latin American countries. All students who referred intention to choose a certain medical specialty were considered as participants. Results Of the 11073 surveyed students, 9235 indicated the name of a specific specialty. The specialties chosen most often in the fifth year were General Surgery (13.0%), Pediatrics (11.0%), Internal Medicine (10.3%) and Obstetrics/Gynecology (9.0%). For women, the top choices were Pediatrics (15.8%), Obstetrics/Gynecology (11.0%), Cardiology (8.7%), General Surgery (8.6%), and Oncology (6.4%). In the adjusted analysis, the female gender was associated with the choice of Obstetrics/Gynecology (RP: 2.75; IC95%: 2.24–3.39); Pediatric Surgery (RP: 2.19; IC95%: 1.19–4.00), Dermatology (RP: 1.91; IC95%:1.24–2.93), Pediatrics (RP: 1.83; IC95%: 1.56–2.17), and Oncology (RP: 1.37; IC95%: 1.10–1.71). Conclusions There is an association between the female gender and the intention to choose Obstetrics/Gynecology, Pediatrics, Pediatric Surgery, Dermatology, and Oncology. We recommend conducting studies that consider other factors that can influence the choice of a medical specialty. PMID:27519055

  13. Patients' experience of choosing an outpatient clinic in one county in Denmark: results of a patient survey

    Directory of Open Access Journals (Sweden)

    Gut Rikke

    2011-10-01

    Full Text Available Abstract Background Research on patients' choice of hospital has focused on inpatients' rather than outpatients' choice of provider. We have investigated Danish outpatients' awareness and utilisation of freedom of choice of provider; which factors influence outpatients' choice of hospital, and how socio-demographic variables influence these factors in a single uptake area, where patients were free to choose any public hospital, where care was provided free at the point of delivery, and where distance to the closest hospitals were short by international standards. Methods Retrospective questionnaire study of 4,232 outpatients referred to examination, treatment, or follow-up at one of nine somatic outpatient clinics in Roskilde County in two months of 2002, who had not been hospitalised within the latest 12 months. The patients were asked, whether they were aware of and utilised freedom of choice of hospital. Results Fifty-four percent (2,272 patients filled in and returned the questionnaire. Forty-one percent of respondents were aware of their right to choose, and 53% of those patients utilised their right to choose. Awareness of freedom of choice of provider was reported to be especially high in female outpatients, patients with longer education, salaried employees in the public sector, and in patients referred to surgical specialties. Female outpatients and students were especially likely to report that they utilised their right to choose the provider. Short distance was the most important reason for outpatients' choice, followed by the GP's recommendations, short waiting time, and the patient's previous experience with the hospital. Conclusions Outpatients' awareness and utilisation of free choice of health care provider was low. Awareness of freedom of choice of provider differed significantly by specialty and patient's gender, education and employment. Female patients and students were especially likely to choose the clinic by themselves

  14. Specific phobias.

    Science.gov (United States)

    Hamm, Alfons O

    2009-09-01

    Exposure based treatments in which patients are systematically confronted with their feared objects of situations are highly effective in the treatment of specific phobias and produce stable improvement both in reported fear and behavioral avoidance. Exposure in reality is more effective in most cases than exposure in sensu. For situations that are difficult to realize, exposure in virtual environments has become increasingly valuable. Exposure in vivo is clearly superior to pharmacotherapy, although cognitive enhancers have been successfully used recently to increase the effect of exposure therapy. The induction of relaxation is not a necessary precondition for exposure therapy. Rather the current mechanisms of change focus on extinction learning as being the central mechanism both on a cognitive level namely that the feared object is no longer associated with severely threatening consequence but also on an affective level, meaning that feared cue is no longer capable to activate the fear circuit in the brain. Accordingly future diagnostic categorizations of phobic disorders in the DSM-V should rather focus on the pattern of the fear response that needs to be changed than on the eliciting cues or situations that are avoided. PMID:19716991

  15. An extended L-curve method for choosing a regularization parameter in electrical resistance tomography

    Science.gov (United States)

    Xu, Yanbin; Pei, Yang; Dong, Feng

    2016-11-01

    The L-curve method is a popular regularization parameter choice method for the ill-posed inverse problem of electrical resistance tomography (ERT). However the method cannot always determine a proper parameter for all situations. An investigation into those situations where the L-curve method failed show that a new corner point appears on the L-curve and the parameter corresponding to the new corner point can obtain a satisfactory reconstructed solution. Thus an extended L-curve method, which determines the regularization parameter associated with either global corner or the new corner, is proposed. Furthermore, two strategies are provided to determine the new corner-one is based on the second-order differential of L-curve, and the other is based on the curvature of L-curve. The proposed method is examined by both numerical simulations and experimental tests. And the results indicate that the extended method can handle the parameter choice problem even in the case where the typical L-curve method fails. Finally, in order to reduce the running time of the method, the extended method is combined with a projection method based on the Krylov subspace, which was able to boost the extended L-curve method. The results verify that the speed of the extended L-curve method is distinctly improved. The proposed method extends the application of the L-curve in the field of choosing regularization parameter with an acceptable running time and can also be used in other kinds of tomography.

  16. The Main Motivations of Ukrainian Students Who Choose to Study in Poland

    Directory of Open Access Journals (Sweden)

    Rębisz Sławomir

    2015-12-01

    Full Text Available Students’ educational migration is one of the phenomena characteristic of the globalization processes. It has been growing dynamically since the 1970s. A number of young people studying abroad has grown globally from 0.8m in 1975 to almost 5m in 2014. It comes therefore as no surprise that educational migration has become a subject of many sociological and economic studies. Their authors usually use the push-pull factors model i.e. they investigate the factors that “push” students out of their own countries and those that “pull” them to the new place of study. Our research on foreign students in Poland has been approached from a similar angle. In fact, we set out to find an answer to the question “What made foreign students from Ukraine leave their country and why did they choose to study in Poland?” To find our answers we conducted questionnaire interviews on a random purposive sample of foreign students from Ukraine (N=83. In addition, to avoid the risk that the resulting correlations were accidental and the knowledge yielded in this way false, we also used the triangulation procedure – a supporting, in-depth qualitative study involving a focus group. We altogether managed to hold 4 sessions. The results obtained in the questionnaire study and in the focus group sessions were sorted and analyzed statistically (quantitative and qualitative analysis, which allowed us to find out about the main motives influencing students’ migration decisions as well as the factors “pushing” them out of Ukraine and attracting them to Poland.

  17. Ecological assessment of water quality in relation to hydrogeology in a shallow urban aquifer: Somesul Mic River aquifer (North-Western, Romania)

    Science.gov (United States)

    Iepure, Sanda; Marin, Constantin; Fekete, Alexandru; Rajka, Geza; Brad, Traian; Samsudean, Cristian

    2014-05-01

    The River Basin Management Plan is the main instrument for the implementation of the Water Framework Directive (2000/60/CE), one of its main requirements being the evaluation and quantification of human impacts on aquatic environments including the groundwater or groundwater dependent ecosystems. The Someş-Tisa basin is the largest hydrographical basin in NW Romania (22,380 km2), containing 15 Quaternary detrital groundwater bodies prone to intensive agricultural and urban industrial use. So far, no studies have addressed the groundwater fauna assemblages and their ecological response to human disturbances and aquifer contamination. Here we investigate a Quaternary shallow detrital aquifer (urban-industrial and agricultural contaminants, aiming to evaluate the sensitivity and structural patterns of groundwater crustaceans communities to aquifer contamination with trace metals (Cr, Mn, Co, Ni, Cu, Zn, Cd, Mo, Pb), As, Se and nitrates. We conducted a survey in seven monitoring boreholes (1-8 m beneath the surface) through the Quaternary porrous aquifer of the Somesul Mic River on a 10 km long longitudinal transect. Hydrologic and geologic variables (rainfall amount, drainage network density, aquifer and drainage elevation, transmisivity and aquifer porosity) were extracted from previous works and Pearson correlations were calculated for paired variables. Water and faunal sampling was performed on a seasonal basis at one pristine and six impacted sites during 2013. Invertebrates were sampled with a submersible pump by extracting a volume of 50-100 l of water and filtering through a 63 microns planktonic net. Subsequently, 2 l of water was extracted after pumping for compositional analyses of major constituents, trace elements (by ICP-MS) and nutrients. The results of water geochemical analyses indicate a significant pollutant charge of groundwater with Mn (max. 29.26 μg/l), Ni (16.55 μg/l), Fe (509.74 μg/l), As (3.87 μg/l), Se (5.07 μg/l), sulphates (549.9

  18. Inhibition of the binding of MSG-intermolt-specific complex, MIC, to the sericin-1 gene promoter and sericin-1 gene expression by POU-M1/SGF-3

    OpenAIRE

    Kimoto, Mai; Kitagawa, Tsuyuki; Kobayashi, Isao; Nakata, Tomohiro; Kuroiwa, Asato; Takiya, Shigeharu

    2012-01-01

    The sericin-1 gene encoding a glue protein is expressed in the middle silk gland (MSG) of the silkworm, Bombyx mori. A member of the class III POU domain transcription factors, POU-M1, was cloned as the factor bound to the SC site of the sericin-1 promoter and has been proposed to be a positive transcription factor. In this study, we analyzed the expression pattern of the POU-M1 gene in fourth and fifth instars in comparison with the pattern of the sericin-1 gene. The POU-M1 gene was expresse...

  19. Factors influencing South African optometry students in choosing their career and institution of learning

    Directory of Open Access Journals (Sweden)

    K. P. Mashige

    2011-12-01

    Full Text Available Thechoice of an appropriate career, occupation or profession is one of the most important decisions hat one makes in life and there are many factors which may influence such a decision. The purpose of this study was to establish the factors which influenced students currently studying optometry in South African institutions in deciding on the course of study and choice of institution. Data was collected with a questionnaire on demographics of the students and the factors that might have influenced their choice of optometry as a career and their institution of learning. Data was analysed with descriptive and cross-tabulation statistics. Three hundred and eighty seven students responded to the questionnaire (80.1% response rate. Their ages ranged from 17 to 40 years with a mean of 20.73 ± 2.46 years and included 30.5% males and 69.5% females. They were from the University of Free State 25.1%, University of Johannesburg (29.5%, University of KwaZulu-Natal (29.7% and the University of Limpopo(15.7%. There were 38% Whites, 36.7% Blacks, 22.2% Indians and 3.1% Coloureds. The highest rated factors which influenced their choice of optometry were the desire to help other people (92.8%, job availability after graduation (92%, subjects passed and points obtained in the matric year (91.2% and the potential to earn a good salary (88.6%, respectively. Few rated news and other media (20.9% as an important factor in their decision to choose their current institution of learning while 29.5% reported that failure to gain admission to study other degrees was an important factor. These results may be useful to institutions offering optometry degrees to formulate effective recruitment strategies to attract quality students. Also, they may be useful to career counsellors in counselling prospective students on their career choice and institution of learning. (S Afr Optom 2011 70(1 21-28

  20. Producción orgánica de tomate mediante la aplicación de humus de lombriz y EcoMic® en condiciones de casa de cultivo

    Directory of Open Access Journals (Sweden)

    Reinaldo Cun G.

    2008-01-01

    Full Text Available El trabajo se desarrolló con el objetivo de comparar el efecto de los biofertilizantes EcoMic® y el humus de lombriz, aplicados al tomate (var. HA 3019 cultivado en condiciones protegidas sobre un suelo Ferralítico Rojo compactado. El estudio se realizó en áreas del Centro de Capacitación y Producción (CCP de la Asociación Cubana de Trabajadores Agrícolas y Forestales (ACTAF durante el invierno del 2005. Los tratamientos consistieron en : (T1, aplicar humus de lombriz (2 kg/m2, antes del trasplante y EcoMic® (1 kg/m2 después del transplante; (T2, aplicar humus de lombriz (2 kg/m2 antes del trasplante y la misma dosis a los 10 días después del trasplante. El rendimiento obtenido en el tratamiento T1 fue mayor (8,4 kg/m2 al T2 (5,01 kg/m2 . La mayor cantidad de frutos con mejor calidad se alcanzó en el tratamiento donde se incluyo el EcoMic® (T1. Desde el punto de vista económico el mayor beneficio neto (8 368 pesos y la mayor relación Beneficio/Costo (1,88, se obtuvo en el tratamiento 1 .La aplicación de estos productos indicó que es factible obtener rendimientos aceptables de tomate sin la utilización de fertilizantes químicos, lo que contribuye a la no contaminación del medio ambiente.

  1. [Systematization of diseases and lesions of the endometrium by etiological and pathogenetical mechanisms of development to choose an optimal treatment].

    Science.gov (United States)

    Boroda, A M

    2004-03-01

    Current clinical gynecology considers pathological states of endometrium (PSE) as one of the most challenging issue of the day. Many questions of etiology, pathogenesis, diagnostics, and treatment of PSE are still under discussion. Nowadays there isn't a whole agreed classification of PSE. Morphological classification remains the most widely used one, but morphological changes occurring in the endometrium don't show a wide variety of disorders related to these pathological states. A new clinicopathogenetic classification of PSE was proposed, which is based on choosing the optimal treatment with functional state of the disease taken into account. This classification helps us to perceive the problem as a whole with choosing functionally based treatment for each patient.

  2. Factors Students Use in Choosing to Attend Church of Christ Institutions of Higher Education when Students Have No Affiliation with the Church of Christ

    Science.gov (United States)

    Wood, Michael B.

    2010-01-01

    Choosing a post-secondary institution to further one's education is a significant decision in a person's life. Throughout the past three decades, the issue of college choice has been researched. Much of this research has dealt with factors that influence student choice. While the research on how and why students choose a post-secondary institution…

  3. La gestió del temps periescolar com a estratègia d’aprenentatge en la millora dels resultats acadèmics en l’educació secundària obligatòria

    OpenAIRE

    Barberá Cebolla, Juan Pedro

    2016-01-01

    Són moltes les variables i els condicionants implicats en l’aprenentatge responsables d’un adequat o inadequat rendiment acadèmic es considera que la gestió del temps d’aprenentatge periescolar es constitueix en sí mateixa en una variable que pot explicar en gran mesura els entrebancs que se li poden presentar a l’alumnat al llarg de la vida d’aprenentatge escolar. Estudiar comporta de forma generalitzada dedicar certa quantitat de temps el que requereix d’una dosi d’habilitats i estratègies ...

  4. 浅谈对微课、慕课、翻转课堂、混合式学习的认识%Brief Talk about the Knowledge of Mic-Class, MOOC, Flipped Class and Mixed Learning

    Institute of Scientific and Technical Information of China (English)

    张维敏

    2016-01-01

    文章针对当前出现的一些主流热门的教学方法,介绍了微课、慕课、翻转课堂、混合式学习的概念,并阐述了它们之间的关系。%The article not only introduces the theories of mic-class, MOOC, flipped class and mixed learning, but also claims their relationship in allusion to the popular teaching methods nowadays.

  5. Análisis de las construcciones narrativas del espacio y del tiempo en los cómics de los escolares de tercer ciclo de enseñanza primaria

    OpenAIRE

    Segovia Aguilar, Blas

    2009-01-01

    El objeto de estudio de la presente tesis es el análisis de las peculiaridades discursivas de los cómics realizados por el alumnado de tercer ciclo de Enseñanza Primaria, con la intención de comprender los procesos, habilidades y estrategias que los niños de 10 a 12 años utilizan cuando narran con imágenes y palabras. La creación de este tipo de textos supone el dominio, por parte de sus autores, de habilidades relacionadas con la construcción narrativa - el espacio y el tiempo-, con el leng...

  6. A study to assess the perceptions of first year medical students for choosing medical school as a career

    Directory of Open Access Journals (Sweden)

    Ranjana Tiwari

    2016-07-01

    Conclusions: These data showed that the maximum percentages of the Medical Students were satisfied with the medical school as 95 (91.34% but still some of them have regrets. In choosing medical school they wants to help poor, earn money and personal development, and influenced by some doctor relative. These were important factors for decision making in medical school. [Int J Res Med Sci 2016; 4(7.000: 2649-2655

  7. The Design Of Equity Ownership Structure In Inter-Firm Relationships: Do Managers Choose According To Theory?

    OpenAIRE

    Prasahant Kale; Phanish Puranam

    2013-01-01

    Theories explaining the equity ownership structure of inter-firm relationships, such as the resource-based view or transaction cost economics, commonly assume a significant role for managerial choice, but this assumption is rarely assessed for its realism. In this study, we use the policy capture methodology to directly assess whether managers choose according to theory (and which theory). In a sample of 66 experienced managers, we find that managerial choices of equity ownership are indeed i...

  8. WHY SHOULD THE WHOLE BUSINESS ENVIRONMENT AND BUSINESS RELATED ORGANIZATIONS CHOOSE AND SUPPORT THE DEVELOPING CLUSTERING PROCESS?

    OpenAIRE

    Constantin BORDEI

    2016-01-01

    This paper represents a brief though concentrated review on the common aspects that are pursued when dealing and talking about the concept of cluster, also displaying some motivating reasons for the companies, institutions and all related entities to choose and support the clustering process. The clusters represent geographical concentrations of companies that are interrelated, which have developed connections with other organizations, such as professional agencies, governmental agencies, res...

  9. Role models play the greatest role – a qualitative study on reasons for choosing postgraduate training at a university hospital

    OpenAIRE

    Stahn, Bonnie; Harendza, Sigrid

    2014-01-01

    [english] Objective: Why physicians choose a certain specialty at a university hospital for their postgraduate training is incompletely understood. Our aim was to identify factors that led physicians from different generations to opt for postgraduate training in a specialty with high or low patient contact at a university hospital. Methods: We conducted 14 semi-structured interviews with residents and attending physicians from the departments of Internal Medicine (high patient contact) and La...

  10. Perceptions, Attitudes, and Choosing to Study Foreign Languages in England: An Experimental Intervention

    Science.gov (United States)

    Taylor, Florentina; Marsden, Emma J.

    2014-01-01

    The declining interest in foreign languages in English-speaking countries has been attributed to negative societal attitudes and specific pupil attitudes and perceptions. While various initiatives have aimed to encourage language study, little research has systematically documented the relationship among perceptions, attitudes, and actually opting…

  11. Investigation of Motion Induced Errors in Scatter Correction for the HRRT Brain Scanner. In: 2010 IEEE Nuclear Science Symposium, Conference Record (MIC), IEEE 2010

    DEFF Research Database (Denmark)

    Anton-Rodriguez, J M; Sibomana, Merence; Walker, M D;

    2010-01-01

    Patient motion during PET scans introduces errors in the attenuation correction and image blurring leading to false changes in regional radioactivity concentrations. However, the potential effect that motion has on simulation-based scatter correction is not fully appreciated. Specifically for tra...

  12. How do households choose between health providers? results from qualitative fieldwork in Burkina Faso

    OpenAIRE

    Gemignani, Regina; Wodon, Quentin

    2012-01-01

    This paper provides results from qualitative fieldwork conducted in 2010 in Burkina Faso to understand the factors that lead households to rely on traditional as opposed to modern health providers, and within modern providers, on faith-inspired as opposed to public facilities. While there is an overall preference for modern care, households still rely on traditional healers for specific health issues that they encounter. As to the choice between modern providers, faith-inspired clinics and ho...

  13. Choosing Important Health Outcomes for Comparative Effectiveness Research: A Systematic Review

    OpenAIRE

    Gargon, Elizabeth; Gurung, Binu; Medley, Nancy; Altman, Doug G.; Blazeby, Jane M; Clarke, Mike; Williamson, Paula R.

    2014-01-01

    Background A core outcome set (COS) is a standardised set of outcomes which should be measured and reported, as a minimum, in all effectiveness trials for a specific health area. This will allow results of studies to be compared, contrasted and combined as appropriate, as well as ensuring that all trials contribute usable information. The COMET (Core Outcome Measures for Effectiveness Trials) Initiative aims to support the development, reporting and adoption of COS. Central to this is a publi...

  14. THE ROLE OF ROMANIAN MANAGERS PERSONALITY IN CHOOSING A LEADERSHIP STYLE, A COMPARATIVE APPROACH

    OpenAIRE

    Maria-Elena, GHEORDUNESCU

    2014-01-01

    Managers are that empowered group of people, specially trained, who direct, coordinate and direct the work of all members of an organization. Managers are those specialists who can make decisions with a large impact on the business activity. No matter the activity profile or size, companies need good managers, who are able to adapt to the specific economic conditions of our times. This paper aims to study the personality of three managers from Romania, who working in the field of road transpo...

  15. Choosing Words Wisely in Communication With Patients With Heart Failure and Families.

    Science.gov (United States)

    Kelemen, Anne M; Ruiz, George; Groninger, Hunter

    2016-06-01

    The complex and often unpredictable course of heart failure (HF) provides many opportunities for communication between clinicians and patients about important subjects as advance care planning, disease state education, therapeutic options and limitations, and end-of-life care. Studies of patients with HF demonstrate that, when engaging in such complex communication, specific language matters in patient experience and in shared decision-making with providers. To date, clinical reports have outlined useful frameworks for communication with patients with HF but have not yet broached specific language crucial to furthering whole person care, particularly in the complex and emotional realm of advancing disease and transitions to end-of-life care. In this work, the investigators unpack language commonly used in advanced HF care and provide explicit suggestions to better provide such pivotal communication. In conclusion, specific phrasing may significantly impact patient experiences and outcomes. Communication that focuses on the disease itself and the therapy or intervention in question may help remove the patient from potential negative emotions, thus facilitating more objective shared decision-making with the clinician. PMID:27108338

  16. Decision making, psychological wellbeing and psychosocial outcomes for high risk women who choose to undergo bilateral prophylactic mastectomy - A review of the literature.

    Science.gov (United States)

    Glassey, Rachael; Ives, Angela; Saunders, Christobel; Musiello, Toni

    2016-08-01

    A bilateral prophylactic, or preventative, mastectomy (BPM) for women at high risk of developing breast cancer (BC) can reduce their risk of developing the disease by up to 90% (relative risk reduction). An increasing number of women, including young women, are taking up this option. However, there is a dearth of information for younger women (under 40 years) choosing preventative mastectomy. In fact, no studies to date have specifically focused on younger women's experiences of a BPM and investigated their informational needs. The purpose of this review is to report on the current literature surrounding the psychological experience of a BPM and the informational needs for women at high risk of developing BC with a particular emphasis on younger women. Research has highlighted a range of psychological outcomes linked to preventative mastectomy, including positives such as reduced anxiety and negatives including impaired body image and sexuality. The literature strongly suggests women want more information surrounding BPM, particularly related to the after effects of the surgery, and the impact on their psychological wellbeing. Research method limitations and reporting has resulted in conflicting conclusions, making it difficult for women to be well informed. In particular, there has been little focus on the experiences and needs of younger women opting for BPM. Due to the unique needs of younger women and an increase in BPM rates for younger women, it is imperative that the needs of this group are addressed. Together these findings provide justification and recommendation for further research in this area. PMID:27318167

  17. Motivation for choosing teaching as a career - the perspective of pre-service teachers, novices and experienced subject teachers

    Directory of Open Access Journals (Sweden)

    Simić Nataša

    2015-01-01

    Full Text Available Since motivation for choosing the teaching profession figures as one of the most important determinants of the successfulness of teachers and even their students, this paper is aimed at investigating the factors of choosing teaching as a career. For that purpose, semi-structured interviews were conducted with the students of “teacher training” faculties, novices and subject teachers with more than five years of work experience (N=76. Thematic analysis was used to identify nine categories of motivational factors: Working with young people (the desire to have a dynamic and creative job in the surroundings of young people, Influence on students (the motivation to exert influence on students’ socio-emotional development, values and education, Dealing with the subject (the motivation for dealing with the science that the person studied, Class teacher/Teacher/Parents as a role model (the motivation stemming from the influence of significant others, Lecturing (the desire to “transfer knowledge”, Lifelong learning (the desire for permanent learning in different fields, Working hours and holidays (the motivation due to working hours and holidays, Fit with the abilities (the desire to realise the “naturally given” abilities and Reputation (the desire to be appreciated in the society. In keeping with the results of other studies, it has been found that altruistic motivation for the choice of teaching as a career is dominant, while extrinsic motivation is least present. The findings are interpreted in the light of the current models of motivation for choosing teaching as a career and the characteristics of teachers’ education and status in Serbia. [Projekat Ministarstva nauke Republike Srbije, br. 179018: Identifikacija, merenje i razvoj kognitivnih i emocionalnih kompetencija važnih društvu orijentisanom na evropske integracije

  18. Stated preferences of doctors for choosing a job in rural areas of Peru: a discrete choice experiment.

    Directory of Open Access Journals (Sweden)

    J Jaime Miranda

    Full Text Available BACKGROUND: Doctors' scarcity in rural areas remains a serious problem in Latin America and Peru. Few studies have explored job preferences of doctors working in underserved areas. We aimed to investigate doctors' stated preferences for rural jobs. METHODS AND FINDINGS: A labelled discrete choice experiment (DCE was performed in Ayacucho, an underserved department of Peru. Preferences were assessed for three locations: rural community, Ayacucho city (Ayacucho's capital and other provincial capital city. Policy simulations were run to assess the effect of job attributes on uptake of a rural post. Multiple conditional logistic regressions were used to assess the relative importance of job attributes and of individual characteristics. A total of 102 doctors participated. They were five times more likely to choose a job post in Ayacucho city over a rural community (OR 4.97, 95%CI 1.2; 20.54. Salary increases and bonus points for specialization acted as incentives to choose a rural area, while increase in the number of years needed to get a permanent post acted as a disincentive. Being male and working in a hospital reduced considerably chances of choosing a rural job, while not living with a partner increased them. Policy simulations showed that a package of 75% salary increase, getting a permanent contract after two years in rural settings, and getting bonus points for further specialisation increased rural job uptake from 21% to 77%. A package of 50% salary increase plus bonus points for further specialisation would also increase the rural uptake from 21% to 52%. CONCLUSIONS: Doctors are five times more likely to favour a job in urban areas over rural settings. This strong preference needs to be overcome by future policies aimed at improving the scarcity of rural doctors. Some incentives, alone or combined, seem feasible and sustainable, whilst others may pose a high fiscal burden.

  19. Choosing among possible persons: The ethics of prenatal selection in the postgenomic age.

    Science.gov (United States)

    Mauron, Alex

    2015-01-01

    The "spectre of eugenics" is often raised about various current reproductive practices that imply a form of choice between future possible persons. Some of these practices are linked to genetic technologies such as pre-implantation genetic diagnosis, others merely entail the choice of a procreator having specific traits, such as in artificial insemination with donor. The weight and limits of this reproof of eugenics are examined, with special attention to the conceptual problems resulting from confusing choices involving virtual persons with the selection of existing persons. PMID:26228932

  20. Accelerating progress in Artificial General Intelligence: Choosing a benchmark for natural world interaction

    Science.gov (United States)

    Rohrer, Brandon

    2010-12-01

    Measuring progress in the field of Artificial General Intelligence (AGI) can be difficult without commonly accepted methods of evaluation. An AGI benchmark would allow evaluation and comparison of the many computational intelligence algorithms that have been developed. In this paper I propose that a benchmark for natural world interaction would possess seven key characteristics: fitness, breadth, specificity, low cost, simplicity, range, and task focus. I also outline two benchmark examples that meet most of these criteria. In the first, the direction task, a human coach directs a machine to perform a novel task in an unfamiliar environment. The direction task is extremely broad, but may be idealistic. In the second, the AGI battery, AGI candidates are evaluated based on their performance on a collection of more specific tasks. The AGI battery is designed to be appropriate to the capabilities of currently existing systems. Both the direction task and the AGI battery would require further definition before implementing. The paper concludes with a description of a task that might be included in the AGI battery: the search and retrieve task.