Sample records for chondroma

  1. Intra-articular chondroma of the knee

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    Talwalkar, S.C.; Kambhampati, S.B.S.; Lang Stevenson, A.I. [Oldchurch Hospital, Romford, Essex (United Kingdom); Whitehouse, R. [Manchester University, Department of Radiology, Manchester (United Kingdom); Freemont, A. [University of Manchester, Department of Osteoarticular Pathology, Manchester (United Kingdom)


    Chondromas are tumours that develop in relation to the periosteum and, although they are common around the knee, most reports deal with soft tissue chondromas in para-articular locations or intracortical tumours in extra-articular regions. We report a rare case of an intra-articular chondroma in a 16-year-old boy of Asian origin developing in the region of the medial femoral condyle of the femur and extending into the femoral sulcus and the patellofemoral joint. (orig.)

  2. Intracranial chondroma of the occipital lobe

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    Mobbs, R.J.; Narula, S.; Berger, M.; Kwok, B.C.T. [Prince of Wales Hospital, Sydney, NSW (Australia). Departments of Neurosurgery and Radiology


    A case report of an intracranial chondroma is discussed with emphasis on magnetic resonance imaging. A case is presented of a chondroma originating in the left occipital pole close to the vertex in a 29-year-old female. Pathologic and radiologic findings with emphasis on the MR appearances are reported, followed by a brief discussion of the recent literature involving solitary intracranial chondroma. Copyright (1998) Blackwell Science Pty Ltd 12 refs., 3 figs.

  3. Chondroma of Falx: Case Report of a Rare Condition

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    Shahryar Shahriarian


    Full Text Available Chondroma is a benign tumor which mostly occurs in extremities but also sometimes in brain. Most intracranial chondromas arise from skull base, but chondroma of falx origin is a rare circumstance. Indeed, the intracranial chondromas rise from falx is mostly in relation with syndromic disorders such as Mafuccis syndrome or Olliers syndrome. Here, we reported a rare case of falxian intracranial chondroma in a young man who has normal physical examination and no signs of any syndromic disorder. The goal of this paper was to raise awareness about chondromas and suggest that chondroma be ruled out in any patient with masses arising from falx.

  4. Temporomandibular juxtaarticular chondroma: case report. (United States)

    Vázquez Mahía, Inés; López-Cedrún Cembranos, José Luis; Ferreras Granado, José; Lorenzo Franco, Fernanda


    Chondromas are benign tumours composed of mature hyaline cartilage. We present here the first case in the English language medical literature of juxtaarticular chondroma of the temporomandibular joint in the parotid region. Within the rarity of cartilage disorders of the temporo-mandibular joint (TMJ), this particular condition is a diagnostic curiosity. The patient, a 54 year old woman, presented a right preauricular tumour of 3.5 cm. which had been developing for 4 years. It was not painful but there was a recent symptomology of TMJ dysfunction, with pain and clicks. The diagnostic possibilities of a parotid pleomorphic adenoma and of a cartilage tumour of the TMJ suggested a difficult preoperative differential diagnosis, which influenced our approach regarding therapy. The tumour was excised, preserving the parotid gland. This enabled us to confirm the histological diagnosis of chondroma, composed solely of chondroide tissue. We have described the clinical characteristics of our case, and carried out a review of the relevant literature, emphasising the differential diagnoses.

  5. Imaging features of juxtacortical chondroma in children

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    Miller, Stephen F. [St. Jude Children' s Research Hospital, Department of Radiological Sciences, Memphis, TN (United States)


    Juxtacortical chondroma is a rare benign bone lesion in children. Children usually present with a mildly painful mass, which prompts diagnostic imaging studies. The rarity of this condition often presents a diagnostic challenge. Correct diagnosis is crucial in guiding surgical management. To describe the characteristic imaging findings of juxtacortical chondroma in children. We identified all children who were diagnosed with juxtacortical chondroma between 1998 and 2012. A single experienced pediatric radiologist reviewed all diagnostic imaging studies, including plain radiographs, CT, MR and bone scans. Seven children (5 boys and 2 girls) with juxtacortical chondroma were identified, ranging in age from 6 years to 16 years (mean 12.3 years). Mild pain and a palpable mass were present in all seven children. Plain radiographs were available in 6/7, MR in 7/7, CT in 4/7 and skeletal scintigraphy in 5/7 children. Three lesions were located in the proximal humerus, with one each in the distal radius, distal femur, proximal tibia and scapula. Radiographic and CT features deemed highly suggestive of juxtacortical chondroma included cortical scalloping, underlying cortical sclerosis and overhanging margins. MRI features consistent with juxtacortical chondroma included isointensity to skeletal muscle on T1, marked hyperintensity on T2 and peripheral rim enhancement after contrast agent administration. One of seven lesions demonstrated intramedullary extension, and 2/7 showed adjacent soft-tissue edema. Juxtacortical chondroma is an uncommon benign lesion in children with characteristic features on plain radiographs, CT and MR. Recognition of these features is invaluable in guiding appropriate surgical management. (orig.)

  6. A peculiar site of chondroma: the epiglottis. (United States)

    Yang, Shih-Wei; Lin, Chin-Yew


    Chondroma of the laryngeal cartilage is an uncommon benign cartilaginous neoplasm. The commonest location is the posterior lamina of the cricoid cartilage, followed by the thyroid cartilage. The occurrence of chondroma in the epiglottis is extremely rare. Depending on the size and location of epiglottic chondroma the clinical manifestations are variable and include a lump in the neck, difficulty in swallowing fluids and dyspnea. In this study, an additional rare case of chondroma arising in the epiglottis is reported. The mass was located over the tip of the epiglottis and caused no significant clinical manifestations except for a foreign body sensation in the throat. Endoscopic excision with an adequate free margin was achieved via suspension laryngoscopy under general anesthesia with intubation. The patient was disease-free during a 1-year follow-up period. We present this case to highlight the occurrence of this rare benign lesion in the epiglottis, and stress that it should not be neglected in the differential diagnosis of an epiglottic mass. Conservative surgical excision is the initial treatment of choice and long-term follow-up is necessary.

  7. Condroma maxilar Chondroma of the maxilla

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    J.P. Crestanello Nese


    Full Text Available Los condromas son tumores benignos raros en la región de cabeza y cuello. El objetivo de este artículo es presentar un condroma de la premaxila junto con una revisión de la literatura sobre sus características clínicas, radiográficas, histológicas y terapéuticas. Además, se enfatiza el diagnóstico diferencial con otras lesiones osteolíticas de la región.Chondromas are benign tumours, rare in the head and neck area. The aim of this article is to present an anterior maxillary chondroma and a review of the literature about its clinical, radiological and histological features among with its treatment is done. An emphasis in the differential diagnosis is done because of its similarity with some osteolitic lesions in the area.

  8. Extraskeletal chondroma casuing carpal tunnel syndrome: A case report

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    Kim, Ok Hwa; Kim, Yeon Hee [Haeundae Paik Hospital, Inje University College of Medicine, Busan (Korea, Republic of)


    Carpal tunnel syndrome caused by extraskeletal chondroma has been scarcely reported in the literature. Authors report a case of carpal tunnel syndrome as a result of an extraskeletal chondroma arising within the carpal tunnel, and describe the radiological and pathological findings of the mass. We also discuss the differential diagnosis of the calcified space, occupying lesions that may occur in carpal tunnel.

  9. Chondroma of the skull base and maxilla

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    Kiralj Aleksandar


    Full Text Available Introduction. Chondromas are uncommon benign tumors of cartilaginous origin. Although chonodroma of the jaw is extremely rare, the commonly involved are the anterior portion of the maxilla, condyle and coronoid process. A chondroma is a painless, slow growing tumor causing destruction and exfoliation of teeth. On a radiograph, the tumor appears as a cyst-like radiolucent lesion, while some are sclerotic. The borders are usually ill-defined. Irregular calcifications may be seen with radiolucencies and then it is an osteochondroma. Material and Methods. We present a patient with a resected and histologically proven chondroma of the skull base and maxilla. A 65-year-old female was admitted to our clinic with swelling and breathing difficulties. MRI showed a large soft tissue mass of the skull base and maxilla. Clinicopathological and radiological features were examined by computed tomography (CT and magnetic resonance imaging (MRI. Discussion and Conclusion. Chondromyxoid fibroma (CMF is a rare, benign cartilaginous tumor that often occurs in the metaphyses of proximal tibia, proximal and distal femur and small bones of the foot. The differential diagnosis is wide and includes simple or aneyrismal bone cyst, giant cell tumor, nonossifying fibroma, fibrous dysplasia, enchondroma, chondroblastoma, eosinophilic granuloma and fibrous cortical defect. Our case demonstrates an uncommon occurrence in the maxillary sinus: CMF with nasal, pterygoid and orbital infiltration. In the diagnosis of an intracranial chondrocytic tumor, it is important to distinguish it from enchondroma and chondrosarcoma. MR provides a detailed assessment of soft tissue masses of the craniofacial region, while CT offers superior analysis of bone structure involvement. The present case underlines the importance of MR examination in the diagnosis of soft tissue masses in the craniofacial region.

  10. Soft tissue chondroma of hard palate associated with cleft palate


    Rajendra Nehete; Anita Nehete; Sandeep Singla; Sudhir Sankalecha


    Soft tissue chondroma of palate is very rare. It has never been reported in a cleft palate patient. We report a case of 22-year-old male who came with asymptomatic swelling on the palate since birth, along with complete cleft of secondary palate. He had symptoms related to cleft palate only, i.e., nasal regurgitation and speech abnormalities. Swelling was excised and the cleft palate was repaired. Histopathological examination revealed chondroma of the palate. The patient had no recurrence af...

  11. Orbital Chondroma: A rare mesenchymal tumor of orbit

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    Ruchi S Kabra


    Full Text Available While relatively common in the skeletal system, cartilaginous tumors are rarely seen originating from the orbit. Here, we report a rare case of an orbital chondroma. A 27-year-old male patient presented with a painless hard mass in the superonasal quadrant (SNQ of left orbit since 3 months. On examination, best-corrected visual acuity of both eyes was 20/20, with normal anterior and posterior segment with full movements of eyeballs and normal intraocular pressure. Computerized tomography scan revealed well defined soft tissue density lesion in SNQ of left orbit. Patient was operated for anteromedial orbitotomy under general anesthesia. Mass was excised intact and sent for histopathological examination (HPE. HPE report showed lobular aggregates of benign cartilaginous cells with mild atypia suggesting of benign cartilaginous tumor - chondroma. Very few cases of orbital chondroma have been reported in literature so far.

  12. Characteristic CT and MRI findings of intracranial chondroma

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    Duan, Fuhong; Qiu, Shijun; Liu, Zhenyin; Lv, Xiaofei; Feng, Xia; Xiong, Wei; An, Jie; Chen, Jing; Yang, Weicong; Wen, Chuhong [Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong (China)], E-mail:; Jiang, Jianwei; Chang, Jun [Department of Radiology, The Third Affiliated Hospital of Nantong University, Wuxi, Jiangsu (China)


    Background. Intracranial chondromas are rare benign tumors. To date, few data are available on their neuroradiological features. Purpose. To describe a series of patients with intracranial chondroma and to analyze and discuss the computed tomography (CT) and magnetic resonance imaging (MRI) features that may distinguish chondromas from other intracranial neoplasms. Material and Methods. We retrospectively analyzed clinical and medical imaging data of six patients who had pathologically confirmed intracranial chondromas in our two institutions between July 2006 and September 2011. Both CT and MRI scanning were performed in all six cases. Results. Five tumors were located at the skull base and one originated from the falx. CT images revealed well-demarcated, irregular lobulated and variable density masses with obvious calci?cation (6/6), no or slight enhancement, without peritumoral edema, and frequently accompanied by erosion and destruction of surrounding bone (5/6). Tumor parenchyma appeared heterogeneously hypointense on T1WI, and hyperintense or mixed hyperintense and hypointense on T2WI, while the calcification appeared hypointense on T1WI and T2WI in five cases, demonstrating significant inhomogeneous enhancement on postcontrast MRI, which revealed the typical 'punica granatum seeds' sign. Only one case showed homogeneous low signal intensity on T1WI and high signal intensity on T2WI, and relatively uniform obvious enhancement on postcontrast scans. Conclusion. These characteristic CT and MR findings, combined with the location of the lesions and the history of a long duration of clinical symptoms, may prove helpful in differentiating intracranial chondromas from other more common tumors.

  13. One Case of Pulmonary Chondroma, Rare Benign Tumor of the Lung

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    YANG Kun; YANG Guanghai; LI Jinsong; WANG Jianjun


    @@ Pulmonary chondroma is a rare form of benign neoplasms of the lung, of which the cartilage is the only constituent. Most of the patients with lung chondroma are asymptomatic at the time of diagnosis and the occupying lesion in lung is mostly detected in the routine health examination. The image of pulmonary chondroma is similar to the other benign solitary neoplasms of the lung and the definitive diagnosis can only be established under a microscope after the resection of the tumor. In the present report, a 33-years-old woman with chondroma in the left lower lung was described.

  14. Sella turcica chondroma associated with hypopituitarism - a case report; Condroma de sela turca associado a hipopituitarismo - relato de um caso

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    Bueno, Tarita D.L.S.; Castro, Ana Valeria B.; Haddad, Adriana L. Mendes; Troja, Simone; Camhaji, Andrea; Yamashita, Seizo [UNESP, Botucatu, SP (Brazil). Faculdade de Medicina


    Intracranial chondromas are rare tumors that generally arise from the skull base or at the sphenoid-ethmoidal region. In these sites chondromas may be misdiagnosed as meningiomas, neurinomas or craniopharyngiomas. The authors present the clinical and radiological findings of a patient who underwent survey for excision of a sella turcica chondroma. (author)

  15. Chondroblastoma-like chondroma of the hand: case report. (United States)

    Kuprys, Tomas K; Bindra, Randip; Borys, Dariusz; Nystrom, Lukas M


    Chondroblastoma-like chondroma is a rare tumor that almost exclusively manifests in the hand and presents with a set of unique diagnostic features. This tumor has been described in only a limited number of publications and is thus commonly omitted in the differential diagnosis of hand tumors. The diagnostic imaging and histological specimens may initially appear consistent with a number of relatively more common hand tumors, thereby delaying the diagnosis. We present the case of a 49-year-old woman with chondroblastoma-like chondroma of the hand treated with marginal excision. The physical examination, imaging, and needle biopsy made an initial case for giant cell tumor of tendon sheath until histological analysis of the excised specimen yielded the correct diagnosis.

  16. Solitary intracerebral chondroma without meningeal attachment: a case report with review of the literature. (United States)

    Zhan, R-Y; Pan, X-F; Wan, S; Lan, P; Zhang, Y-C; Weng, N-C; Yan, M; Zhou, Y-Q


    Intracranial chondromas are rare, benign cartilaginous tumours that account for meningeal attachment. The epidemiology, aetiology, clinical behaviour, radiological features, histological features and treatment of the case are discussed with a review of previous cases reported in the literature.

  17. Sellar Chondroma with Endocrine Dysfunction that Resolved after Surgery: Case Report. (United States)

    Hattori, Yujiro; Tahara, Shigeyuki; Nakakuki, Takuya; Takei, Mao; Ishii, Yudo; Teramoto, Akira; Morita, Akio


    Chondromas originating from the sella turcica are rare, and the most common initial symptoms are headache and visual disturbance. We describe a case of sellar chondroma with endocrine impairment as an initial manifestation that completely resolved after surgery. A 40-year-old Japanese woman with amenorrhea and galactorrhea for the last 2 years was referred to our department of neurosurgery for the evaluation of high prolactin levels and a tumor in the sella turcica. A biochemical assessment indicated endocrine dysfunction. Magnetic resonance imaging and computed tomography indicated a tumor in the sella turcica. The patient's presentation favored the preoperative diagnosis of pituitary adenoma or Rathke's cleft cyst. However, because calcification was detected, other types of tumors, such as craniopharyngioma, meningioma, and chordoma, were also considered. Endoscopic transsphenoidal surgery was performed, and the possibility of a bony tumor was recognized. Finally, the tumor was completely removed, and the histopathological findings confirmed chondroma. The postoperative course was uneventful, and endocrine function improved. Five years after surgery, the patient is doing well without pituitary insufficiency, pituitary hormone medications, or signs of tumor recurrence. In cases of sellar chondroma, endocrine dysfunction sometimes precedes other symptoms, such as headache and visual disturbance. When examining a patient with an intrasellar tumor harboring calcification, clinicians must consider the possibility of sellar chondroma. Furthermore, to the best of our knowledge, this case is the first of sellar chondroma treated with endoscopic surgery to be reported.

  18. Chondroma within the flexor hallucis longus tendon sheath. A case report and literature review. (United States)

    Brahms, M A; Fumich, R M


    Chondromas in tendon sheaths are a rare entity proviously reported in the flexor sheaths on the hand and possibly the foot. This is the first reported case of condroma of the flexor hallucis longus tendon sheath at the ankle region. A literature review with regard to pathogenesis, classification, and recurrence has been presented.

  19. [Subperiosteal (juxtacortical) chondroma of the hand. Apropos of 2 cases. Review of the literature]. (United States)

    Baudrillard, J C; Lerais, J M; Schernberg, F; Gillier, P; Toubas, O; Durot, J F


    Subperiosteal chondroma (juxta-cortical) is unusual benign cartilaginous neoplasm with characteristic radiographic features. We report two cases occurring in uncommon location: the hand. Radiologic differential diagnosis with others bone tumors is easy but it could be difficult with some soft-tissue tumors, especially chondrosarcoma and extraarticular chondromatosis.

  20. [Intracranial chondroma arising from the skull base: two case reports featuring the image findings for differential diagnosis]. (United States)

    Higashida, Tetsuhiro; Sakata, Katsumi; Kanno, Hiroshi; Tanabe, Yutaka; Kawasaki, Takashi; Yamamoto, Isao


    We reported two cases of intracranial skull base chondroma and discussed the differential diagnosis and the treatment strategies. The first case was a 39-year-old male who presented with left exophtalmos, visual loss and oculomotor disturbance. MRI showed a huge tumor occupying the bilateral cavernous sinus. Partial removal of the tumor was performed through the left orbitozygomatic subtemporal approach. The second case was a 54-year-old male who presented with left hemiparesis. MRI showed a brain stem infarction with a huge tumor located at the right middle fossa. Partial removal was performed through the right orbitozygomatic subtemporal approach. In these two cases, the histopathological diagnosis of the tumors was benign chondroma and the size of residual tumors have not changed for one year without any additional therapy. Although preoperative definite diagnosis for skull base chondromas is difficult, strategies for diagnosis and treatment without any complication are essential. In our cases, chondromas showed low uptake in PET images, which might be useful for differentiation between chondromas and chordomas. The current popular surgical approach for parasellar tumors is transcranial such as the orbitozygomatic subtemporal approach. In surgical removal of skull base chondromas, it is advisable to try to confirm the diagnosis preoperatively with characteristic image findings and to consider the best approach in each case to decompress the involved nerves without any complications.

  1. A large extraskeletal chondroma in the hand of an elderly patient--a case report. (United States)

    Ikeda, Kazuo; Osamura, Naoki; Kasashima, Satomi


    This paper examines a case of extraskeletal chondroma in the hand of an 82-year-old female, first noticed about two years ago. Magnetic resonance imaging showed a mass in the carpal tunnel which extended from the wrist to the palm. The tumor was located between the thenar area and the hypothenar area at the palm level. There was no continuity to the carpal bone or radius bone. The entire size of the tumor was 120 mm × 45 mm × 42 mm. Although extraskeletal chondroma is sometimes seen, a large one in the hand is extremely rare. Since the tumor was too large to excise totally because median nerve entrapped it, it was divided into two parts and excised. After the operation, there was no neurological deficit or pain in the median nerve lesion.

  2. [Chondroma adjacent to Meckel's cave mimicking a fifth cranial nerve neurinoma. A case report]. (United States)

    Narro-Donate, Jose María; Huete-Allut, Antonio; Velasco-Albendea, Francisco J; Escribano-Mesa, Jose A; Mendez-Román, Paddy; Masegosa-González, Jose


    Cranial chondromas are tumours arising from chondrocyte embryonic remnants cells that usually appear in the skull base synchondrosis. In contrast to the rest of the organism, where chondroid tumours are the most common primary bone tumour just behind the haematopoietic lineage ones, they are a rarity at cranial level, with an incidence of less than 1% of intracranial tumours. The case is reported on a 42 year-old male referred to our clinic due to the finding of an extra-axial lesion located close to the Meckel's cave region, with extension to the posterior fossa and brainstem compression after progressive paraparesis of 6 months onset. With the diagnosis of trigeminal schwannoma, a subtotal tumour resection was performed using a combined supra-infratentorial pre-sigmoidal approach. The postoperative histopathology report confirmed the diagnosis of cranial chondroma.

  3. FGFR3 Deficiency Causes Multiple Chondroma-like Lesions by Upregulating Hedgehog Signaling.

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    Siru Zhou


    Full Text Available Most cartilaginous tumors are formed during skeletal development in locations adjacent to growth plates, suggesting that they arise from disordered endochondral bone growth. Fibroblast growth factor receptor (FGFR3 signaling plays essential roles in this process; however, the role of FGFR3 in cartilaginous tumorigenesis is not known. In this study, we found that postnatal chondrocyte-specific Fgfr3 deletion induced multiple chondroma-like lesions, including enchondromas and osteochondromas, adjacent to disordered growth plates. The lesions showed decreased extracellular signal-regulated kinase (ERK activity and increased Indian hedgehog (IHH expression. The same was observed in Fgfr3-deficient primary chondrocytes, in which treatment with a mitogen-activated protein kinase (MEK inhibitor increased Ihh expression. Importantly, treatment with an inhibitor of IHH signaling reduced the occurrence of chondroma-like lesions in Fgfr3-deficient mice. This is the first study reporting that the loss of Fgfr3 function leads to the formation of chondroma-like lesions via downregulation of MEK/ERK signaling and upregulation of IHH, suggesting that FGFR3 has a tumor suppressor-like function in chondrogenesis.

  4. Condroma de sela turca associado a hipopituitarismo: relato de um caso Sella turcica chondroma associated with hypopituitarism: a case report

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    Tarita D.L.S. Bueno


    Full Text Available Os condromas intracranianos são raros, sendo mais comumente encontrados na base do crânio e na região esfenoetmoidal. Nesta localização podem ser confundidos com meningiomas, neurinomas e craniofaringiomas. Os autores apresentam a evolução clínica e as características pela imagem de um paciente portador de condroma da sela turca submetido a excisão tumoral.Intracranial chondromas are rare tumors that generally arise from the skull base or at the sphenoid-ethmoidal region. In these sites chondromas may be misdiagnosed as meningiomas, neurinomas or craniopharyngiomas. The authors present the clinical and radiological findings of a patient who underwent surgery for excision of a sella turcica chondroma.

  5. Condroma de laringe: apresentação atípica Laryngeal chondroma: an atypical presentation

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    Leonardo C. B. de Sá


    Full Text Available The authors report a case of laryngeal chondroma , a rare benign larynx tumor in the cricoid and arytenoid cartilages. There are aproximately 250 cases previously described in literature. A male, 41 year-old patient, presented a severe and progressive dyspnea leading to tracheostomy. Direct microlaryngoscopy revealed arytenoid enlargement and subglottic stenosis and the endoscopical biopsy was inconclusive, since the tumor present a hard gnistency. We performed surgical excision by laringofissura and total resection of the tumor, with good result. The histopathological examination showed a chondroma with no malignance.

  6. Partial lateral corpectomy associated with pediculectomy to treat extradural chondroma in a dog: technique description

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    P.V.T. Marinho


    Full Text Available This study aimed to describe in detail the surgical technique of partial lateral corpectomy (PLC associated with pediculectomy to treat an in vitro extradural chondroma. A 12-year old female Cocker Spaniel was seen in the hospital with proprioceptive ataxia of hind limbs associated with extradural compression between the 1st and 2nd lumbar vertebrae. The owner opted for euthanasia since the patient's condition changed due to simultaneous illnesses that culminated in a poor prognosis. The patient's body was formally ceded to perform experimental spinal decompression. The technique was effective to completely remove the epidural mass with minimal manipulation of the spinal cord.

  7. Subperiosteal chondroma. Diagnostic value of CT scan imaging in two cases

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    Lerais, J.M.; Auquier, F.; Baudrillard, J.C.; Durot, J.F.; Laugareil, P.; Wallays, C.; Lefort, G.; Daoud, S.; Gaillard, D.


    Results of CT scan exploration are reported in two cases of subperiosteal chondroma, one in a 4 year old child affecting the anterior tibial tuberosity the other in a 9 year old child involving the upper end of humerus. Data from CT scan imaging were undoubtedly superior to those of conventional radiography and appear to be characteristic of this benign cartilaginous tumor, greatly facilitating correlation between clinical, radiological and pathologic findings. The scanner should allow certain situations to be dedramatized and the surgical attitude adapted when the functional prognosis is involved.

  8. [Subperiosteal chondroma. Diagnostic contribution of x-ray computed tomography. Apropos of 2 cases]. (United States)

    Baudrillard, J C; Lerais, J M; Durot, J F; Lefort, G; Daoud, S; Gaillard, D; Auquier, F; Laugareil, P; Wallays, C


    Results of CT scan exploration are reported in two cases of subperiosteal chondroma, one in a 4 year old child affecting the anterior tibial tuberosity the other in a 9 year old child involving the upper end of humerus. Data from CT scan imaging were undoubtedly superior to those of conventional radiography and appear to be characteristic of this benign cartilaginous tumor, greatly facilitating correlation between clinical, radiological and pathologic findings. The scanner should allow certain situations to be dedramatized and the surgical attitude adapted when the functional prognosis is involved.

  9. Chondroblastoma-like chondroma of soft tissue: report of the first case in the base of skull. (United States)

    Raparia, Kirtee; Lin, Jerry W; Donovan, Donald; Vrabec, Jeffrey T; Zhai, Qihui Jim; Ayala, Alberto A; Ro, Jae Y


    Chondroblastoma-like chondroma (CLC) of soft tissue is a rare benign neoplasm that usually involves the soft tissues of the hand. This report describes the first case of CLC of soft tissue arising in the base of the skull. A 33-year-old man was seen with a slow growing mass in the right parotid region of his face. The noncontrast computed tomographic scans showed an 8.5-cm mass with calcifications involving the right masticator space and extending through the bone into the middle cranial fossa. The radiologic differential diagnosis included osteosarcoma, leiomyosarcoma, chondrosarcoma, and giant cell tumor. During surgery, the large lateral skull base tumor appeared to involve the middle and infratemporal fossae and eroded the surrounding bone. Although the tumor was removed piecemeal, total excision was performed. On microscopic examination, the tumor displayed lobules of mature hyaline cartilage with numerous chondroblasts, coarse calcifications including chicken wire calcifications, and scattered osteoclasts. No atypia, mitoses, necrosis, or osteoid formation was seen. The tumor was diagnosed as chondroma with chondroblastoma features of the soft tissue. His postoperative clinical course was uneventful; however, after 7 months, he had a local recurrence identified on follow-up magnetic resonance imaging. He underwent repeat surgical excision of the tumor, which showed similar histology as the previous excision. This large skull based tumor eroding the bone, which clinically and radiologically mimicked a malignant process, was an unusual presentation of a benign cartilaginous neoplasm. Pathologists should be aware that CLC may occur in the base of the skull and this lesion should be differentiated from the other benign or malignant tumors arising in this area. These lesions have a potential for local recurrence; hence, a close follow-up is recommended.

  10. 颅内软骨瘤的C T和MR I表现%CT and MRI imagings of intracranial chondromas

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    刘毅生; 沈家亮; 黄慈花


    目的:回顾性分析9例经手术病理证实的颅内软骨瘤的CT、MRI征象,结合文献,探讨其影像学诊断。方法9例病例中,8例行头部CT扫描;4例行头部 MRI扫描,MRI扫描序列采用自旋回波 T1 WI、T2 WI、FLAIR、DWI 序列及 T1 WI 增强。结果8例病灶位于颅底,1例位于凸面硬膜。CT显示8例病灶内见点条状或边缘弧形钙化,MRI显示4例(4/4)病灶 T1 WI呈低等混杂信号,T2 WI呈高等混杂信号,2例(2/4)T2 WI 见多发结节样或分叶样高信号,2例(2/4)T2 WI 见珊瑚样分隔状等信号并且于T1 WI增强后见分隔明显强化,4例病灶包膜都明显强化。结论颅内软骨瘤有较明显的CT和MRI征象,MRI征象可以反映颅内软骨瘤的病理组织学特点。%Objective To analyse CT and MRI features of intracranial chondromas and review the literatures.9 cases of intracra-nial chondromas confirmed by operation and pathology were presented.Methods Among 9 cases,cerebral CT scan was performed in 8 cases(8/9),MRI scan in 4 cases(4/9)with spin-echo T1 WI,T2 WI,FLAIR,DWI sequences and enhanced T1 WI sequences.Results The lesions located at the skullbase in 8 cases,the dural convexity in 1 case.CT showed that the lesions were spot,strip or arc of fringe calcifications in 8 cases.MRI showed that the lesions were inhomogeneous low and moderate signal intensity on T1 WI and in-homogeneous high and moderate signal intensity on T2 WI in 4 cases(4/4).Multinodular or lobed high signal intensity was seen on T2 WI in 2 cases(2/4),coralline septal moderate signal intensity was seen on T2 WI ,which was obvious enhancement after adminis-tration of contrast medium on T1 WI in 2 cases(2/4),the envelope of the lesions was also obvious enhancement in 4 cases.Conclu-sion CT and MRI features of intracranial chondromas are marked.The MRI features of intracranial chondromas can reflect its path-ologic and histologic characteristics.

  11. Surgical treatment of lumbar extradural chondroma in a dog - case reportTratamento cirúrgico de condroma extradural lombar em cão - relato de caso

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    Paulo Vinícius Tertuliano Marinho


    Full Text Available Neoplasms originating in the spinal canal are uncommon in small animal veterinary clinic, but when present can cause significant neurological signs. Anatomically, these neoplasms can be classified as extradural, intradural-extramedullary and medullary. Extradural neoplasms are located outside the dura mater, but they can cause compression of the spinal cord. The chondromas are benign neoplasms characterized by the formation of cartilage and is rarely located in the spinal canal in both human and veterinary medicine. We describe a case of lumbar extradural chondroma in a dog that surgical decompression and removal of the mass allowed the resolution of clinical signs of paralysis with return of function of the hind limbs of the patient. As neoplasias com origem no canal medular são infrequentes na clínica veterinária de pequenos animais, porém quando presentes podem causar sinais neurológicos importantes. Anatomicamente estas neoplasias podem ser classificadas em extradural, intradural-extramedular e medular. As neoplasias extradurais estão localizadas fora da dura-máter, porém podem causar compressão da medula. Os condromas são neoplasias benignas, caracterizadas pela formação de tecido cartilaginoso sendo rara a sua localização no canal medular tanto em medicina humana como na medicina veterinária. O objetivo deste trabalho é descrever um caso de condroma extradural lombar em cão em que a descompressão cirúrgica e retirada da massa permitiu a resolução dos sinais clínicos de paralisia com retorno da função dos membros pélvicos do paciente.

  12. Condroma pulmonar isolado: caso incompleto da tríade de Carney? Isolated pulmonary chondroma: a case of incomplete Carney triad?

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    Raul Lopes Ruiz Júnior


    Full Text Available Um homem, de 45 anos, com infecções pulmonares de repetição havia quatro anos apresentou-se com tosse, secreção amarelada, escarros hemópticos e dor torácica não pleural. A tomografia revelou nódulo calcificado ocluindo brônquio lobar inferior direito. Realizada bilobectomia inferior e média, o exame histopatológico revelou condroma endobrônquico, bem circunscrito. O condroma pulmonar é um tumor raro, em geral associado à tríade de Carney (condroma, leiomiossarcoma gástrico e paraganglioma extra-adrenal, sendo o menos freqüente dos três componentes. No presente caso, os outros dois componentes não foram observados. Podem, entretanto, se manifestar tardiamente, sendo, assim, necessário seguimento clínico em longo prazo do paciente.A 45-year-old man presented with recurrent pulmonary infection for four years, cough, bloody sputum, yellowish excretion and nonpleuritic chest pain. Tomography of the chest revealed a calcified nodule occluding the right lower lobe bronchus. A right lower and middle lobectomy was performed, and the histopathological examination of the bronchi revealed chondroma, a rare pulmonary tumor usually associated with the Carney triad (pulmonary chondroma, gastric leiomyosarcoma and extra-adrenal paraganglioma, being the less common of the three components. In the present case, the other two components of the triad were not observed. Since these components may appear years later, long-term follow-up care is necessary.

  13. 多发骨膜软骨瘤临床及影像学特点(附5例报告)%Clinical and Imaging Features of Multiple Periosteal Chondromas:5 Cases Report

    Institute of Scientific and Technical Information of China (English)

    葛祖峰; 韩志江; 龚向阳


    Objective To analyze imaging findings and main clinical features of multiple periosteal chondromas. Methods Five cases with multiple periosteal chondromas (one woman and 4 men,age ranged from 2 to 16 years old) confirmed by operation and pathology were included in this report. The imaging findings and main clinical features were retrospectively analyzed,including the distribution, size, shape and CT density (or MRI signal intensity) of lesions. Results Totally 28 bones were affected in the 5 cases.The long tubular bones were predominantly affected in 61% (17/28) of the bones , of that, 28 lesions ( 70 % ) and 12 lesions ( 30% ) localized at the metaphysis and epiphysis respectively. Other affected bones included ilium, pubis, ischium, talus, rib and metatarsus.One patient had multiple foci at single bone, but the other 4 patients had multi-lesions at multiple bones unilaterally or bilaterally.The main imaging features included: (1) Cortical of the bones showed saucer-like defects or perforated changes with sclerotic margins. (2) Large foci demonstrated para-cortical calcification or ossification. (3) Obvious deformations were noted at involves bones,especially at the metaphysis of the long bones and ala of the ilium. (4) CT detected much more small lesions within the cortex which were missed by conventional X-ray films. (5) The juxtacortical soft tissues showed iso-or low signal intensity on MR T1 WI and high signal intensity on T2 WI with irregular margins. The signal intensity of adjacent bone marrow and soft tissues was normal. Clinically, all patients complained of mild pain, swelling and lameness only. Limbs shorten or/and curved deformations occurred in 3 cases.Conclusion Multiple periosteal chondromas have its own imaging and clinical features. Understanding of these features will be helpful for an early diagnosis and a subsequently right management from orthopcdists.%目的 探讨多发骨膜软骨瘤的影像学特点及主要临床表现.方法

  14. Compresión medular dorsal extradural por condroma

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    B. B. Srota


    Full Text Available For the first time in Argentine bibliography a chondroma of the vertebra with extradural dorsal medular compression, is described. The clinical characteristics of the onset by intermitent medular claudication of Dejerine and the painless evolution until surgical intervention, are stressed. The bibliography is put up to date and the radiographics signs and the pathologic anatomy of the chondromas, are studied.

  15. Expression and distribution of bone morphogenetic proteins mRNA in chondroma diseases%软骨肿瘤中骨形成蛋白的原位杂交定位和定量分析

    Institute of Scientific and Technical Information of China (English)

    吕红兵; 金岩; Tipoe GL


    目的 探讨骨形成蛋白2,3,4,5在软骨肉瘤和软骨瘤形成中的作用.方法 运用原位杂交技术,检测软骨肉瘤和软骨瘤中BMP 2,3,4,5 mRNA的分布和定位,并采用图像分析仪对原位杂交的阳性程度进行图像分析.结果 软骨肉瘤中分化较差的梭形细胞中检测有BMP 2,3,4 mRNA的表达,而分化状态较好的圆形、卵圆形细胞中未见阳性信号.软骨基质中未见阳性信号,而软骨瘤中的瘤细胞中只检测到BMP 3 mRNA的表达.结论 BMP表达的种类与软骨肿瘤的类型密切相关,BMP 2,4在软骨肉瘤的发生和形成过程中起重要作用,而BMP 3则与软骨瘤的发生有密切关系.

  16. Tumor formation in Hoffa's infrapatellar fat: Case report

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    Alan de Paula Mozella


    Full Text Available Although tumors or pseudotumoral lesions are rare in the infrapatellar fat, they may affect it. Osteochondroma is the commonest benign bone tumor. However, extraskeletal presentations are rare. There are three extraskeletal variants of osteochondroma: synovial chondromatosis, para-articular chondroma and soft-tissue chondroma. We present a case of a single intra-articular lesion in the area of Hoffa's fat, in a 78-year-old female patient with a complaint of progressive knee pain associated with severe arthrosis. From the clinical and radiological findings, the diagnosis was para-articular osteochondroma. However, the histopathological findings, after excision of the lesion, showed that this was synovial chondromatosis secondary to osteoarthrosis.

  17. 邻皮质(骨膜)软骨瘤(附40例临床X线分析)

    Institute of Scientific and Technical Information of China (English)

    徐德永; 曹庆选等


    邻皮质软骨瘤又称为骨膜软骨瘤(Periosteal chondroma),系罕见而独特的良性软骨类肿瘤,首先由Lichtenstein和Hall(1) (1952)详细描述,而蝗由Jaffe(1958)命名为邻皮质软骨瘤(Juxtacorlical chondroma),近年来国外屡有报告(2,3),至今文献报告已近40例(4-6),国内又见1例短篇报道(10),我们收集了40例。54个肿瘤,均经手术病理证实,兹报告如下。

  18. [Histological varieties of benign tumors of the nasal cavities]. (United States)

    Matanda, R; Kayembre, M; Kalengayi, R; Sabue, M; Muyunga, K


    The frequency of different histological forms of benign tumours of the nasal fossae diagnosed at the Ear-Nose-Throat department of the Kinshasa University Hospital are reported. There were 71 cases reported over a 21 year period, approximately 3 cases per year. Epithelial tumours were the most frequent 59% followed by papillomas (45%) and adenomas (14%). Conjunctive tissue was involved in 41% of the cases: angiomas 17%, fibromas 11%, chondromas 6%, benign haemangiopericytomas 4% and osteomas 3%.

  19. Combined PET/CT by 18F-FDOPA, 18F-FDA, 18F-FDG, and MRI correlation on a patient with Carney triad. (United States)

    Papadakis, Georgios Z; Patronas, Nicholas J; Chen, Clara C; Carney, J Aidan; Stratakis, Constantine A


    Carney triad is a rare syndrome involving gastrointestinal stromal tumor, pulmonary chondroma, and extra-adrenal paraganglioma. We present a 21-year-old woman with the complete triad who was evaluated with MRI, F-FDOPA, F-FDA, and F-FDG. F-FDOPA best demonstrated the paraganglioma, whereas hepatic metastases noted by MRI demonstrated increased uptake only by F-FDG.




    This case concerned a female patient with a complaint of pain in the anterior region of her left knee during and after sports activities, followed by joint blockage three months ago. From imaging examinations, simple radiography of the knee was normal and magnetic resonance showed a solid expansive mass, possibly corresponding to soft-tissue chondroma or focal nodular synovitis. Arthroscopic resection of the lesion was performed, and the diagnosis of diffuse giant cell tumor resembling locali...

  1. MR imaging of the forefoot: Morton neuroma and differential diagnoses. (United States)

    Zanetti, Marco; Weishaupt, Dominik


    Magnetic resonance (MR) imaging of Morton neuromas is highly accurate. Morton neuromas are more conspicuous when the patient is prone positioned and the foot is plantar flexed than in the supine position with the toes pointing upward. MR imaging of Morton neuromas has a large influence on the diagnostic thinking and treatment plan of orthopedic foot surgeons. The most common differential diagnoses include intermetatarsal bursitis, stress fractures, and stress reactions. Some diagnoses (nodules associated with rheumatoid arthritis, synovial cyst, soft tissue chondroma, and plantar fibromatosis) are rare and can be diagnosed with histologic correlation only.

  2. Benign and malignant cartilage tumors of bone and joint: their anatomic and theoretical basis with an emphasis on radiology, pathology and clinical biology. Pt. 1. The intramedullary cartilage tumors

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    Brien, E.W. [Orthopaedic Oncology Service, Orthopaedic Hospital, Los Angeles, CA (United States)]|[Musculoskeletal Tumor Service, Orthopaedic Hospital, Los Angeles, CA (United States); Mirra, J.M. [Orthopaedic Oncology Service, Orthopaedic Hospital, Los Angeles, CA (United States); Kerr, R. [Orthopaedic Oncology Service, Orthopaedic Hospital, Los Angeles, CA (United States)


    We reviewed 845 cases of benign and 356 cases of malignant cartilaginous tumors from a total of 3067 primary bone tumors in our database. Benign cartilaginous lesions are unique because the epiphyseal plate has been implicated in the etiology of osteochondroma, enchondroma (single or multiple), periosteal chondromas and chondroblastoma. In the first part of this paper, we will review important clinical, radiologic and histologic features of intramedullary cartilaginous lesions in an attempt to support theories related to anatomic considerations and pathogenesis. (orig.). With 44 figs., 2 tabs.


    Carvalho Godoy, Fabiola Andrea de; Faustino, Carlos Alberto Cury; Meneses, Cláudio Santos; Nishi, Sergio Tadao; Góes, César Eduardo Giancoli; Canto, Abaeté Leite do


    This case concerned a female patient with a complaint of pain in the anterior region of her left knee during and after sports activities, followed by joint blockage three months ago. From imaging examinations, simple radiography of the knee was normal and magnetic resonance showed a solid expansive mass, possibly corresponding to soft-tissue chondroma or focal nodular synovitis. Arthroscopic resection of the lesion was performed, and the diagnosis of diffuse giant cell tumor resembling localized pigmented villonodular synovitis (PVNS) was made from the result of the anatomopathological examination. The patient presented good clinical evolution, with disappearance of symptoms and return to physical activities.

  4. Benign and malignant cartilage tumors of bone and joint: their anatomic and theoretical basis with an emphasis on radiology, pathology and clinical biology. II. Juxtacortical cartilage tumors

    Energy Technology Data Exchange (ETDEWEB)

    Brien, E.W. [Orthopaedic Oncology Service, Orthopaedic Hospital, Los Angeles, CA (United States)]|[Musculoskeletal Tumor Service, Orthopaedic Hospital, Los Angeles, CA (United States); Mirra, J.M.; Luck, J.V. Jr. [Orthopaedic Oncology Service, Orthopaedic Hospital, Los Angeles, CA (United States)


    In part I, we reviewed the varied clinical presentations, pathogenesis, histologic findings, radiologic findings, and treatment of intramedullary cartilaginous lesions of bone. In this section, we will evaluate our cases and consultations of juxtacortical cartilaginous tumors. Radiographic differential diagnosis includes the numerous juxtacortical lesions particularly osteochondroma, parosteal chondroma, Trevor`s disease, trauma (fracture and periostitis ossificans), and the low- and high-grade surface osteosarcomas. By emphasizing pathogenesis in conjunction with radiographic and histologic findings, pitfalls in diagnosis and subsequent treatment can be avoided in such cases. (orig.) With 32 figs., 2 tabs., 32 refs.


    Carvalho Godoy, Fabiola Andrea de; Faustino, Carlos Alberto Cury; Meneses, Cláudio Santos; Nishi, Sergio Tadao; Góes, César Eduardo Giancoli; Canto, Abaeté Leite do


    This case concerned a female patient with a complaint of pain in the anterior region of her left knee during and after sports activities, followed by joint blockage three months ago. From imaging examinations, simple radiography of the knee was normal and magnetic resonance showed a solid expansive mass, possibly corresponding to soft-tissue chondroma or focal nodular synovitis. Arthroscopic resection of the lesion was performed, and the diagnosis of diffuse giant cell tumor resembling localized pigmented villonodular synovitis (PVNS) was made from the result of the anatomopathological examination. The patient presented good clinical evolution, with disappearance of symptoms and return to physical activities. PMID:27027040

  6. Follow-up study of cartilaginous bone tumors.

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    Full Text Available A series of clinical and pathological studies were performed on 74 cartilaginous bone tumors including osteochondromas, multiple cartilaginous exostoses, chondromas, chondromatoses, benign chondroblastomas and chondrosarcomas. Resection was adequate for the osteochondromas, and no recurrence was observed. Out of 14 multiple cartilaginous exostoses, three, all in flat bones showed malignant change. The predominant sites of chondroma were the finger and toe bones, and curettage and bone graft was adequate treatment. Neither recurrence nor malignant change was observed. Two cases of chondromatosis, one of Ollier's disease and one of Maffucci's syndrome, were included in our series. Leg length discrepancy and pathologic fracture were common problems in chondromatosis. Moreover, malignant change was suspected in a hemangioma of the Maffucci's syndrome patient. Benign chondroblastoma was treated by curettage and bone graft, with no recurrence. In our series, 4 primary and 3 secondary chondrosarcomas were observed. Metastasis was seen in only one case. Because of the discrepancy between the biological behavior and histological findings of cartilaginous bone tumors, the malignancy of tumors should be evaluated by clinical signs and symptoms as well as by histological findings.

  7. Chondrogenic Lesions of the Skeletal System Using Radiographs, CT and MRI

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    Akbar Bonakdarpour


    Full Text Available Benign Tumors: Chondroma, chondroblastoma,"nchondromyxoid fibroma, osteochondroma"nChondroma"n1. Enchondroma"n2. Periosteal Chondroma"n3. Enchondromatosis"n4. Metachondromatosis"nEnchondroma is a benign metaphyseal tumor. The"nmajor differential diagnoses are bone infarct and"nchondrosarcoma. Calcification in enchondroma"nhas a popcorn appearance and on radiographs and"nCT they may be counted. Calcified bone infarct"nhas an appearance similar to rotten metal. Central"nchondrosarcoma shows cortical erosion more than"ntwo thirds of the thickness of cortex and also periosteal"nreaction. Pain and growth of lesion in adulthood raises"nthe possibility of malignant transformation."nPeriosteal chondroma: This lesion arises from the"nperiosteum without involving the medullary bone."nThe most common location is the upper humerus."nEnchondromatosis reveals multiple enchondromas,"npredominantly involving one side of the skeleton."nMalignant transformation is the major complication"nof enchondromatosis. In malignant transformation,"nMRI shows that perichondrium is more than 1 cm"nthick in adults and more than 3 cm thick in children."nIn the hands and feet, enchondromatosis should not"nbe confused with fibrous dysplasia. Mafucci syndrome"nis enchondromatosis associated with cavernous"nhemangiomas with a prognosis worse than enchondr"nomatosis."nMultiple hereditary cartilaginous exostoses: This is"nof metaphyseal origin and pedunculated forms grow"naway from the adjacent joint. Sessile osteochondromas"nare broad based; if their surface is irregular they are"nsuspicious of malignancy. Pain and growth of the"nlesion after closure of the epiphyseal plate are warning"nsigns of malignant transformation. In malignant"ntransformation MRI shows that perichondrium is"nmore than 1 cm thick in adults and more than 3 cm"nthick in children."nChondroblastoma: This is a benign tumor, seen before"nclosure of epiphyseal plate, with a sclerotic border."n30 to 50% show

  8. Tríada de Carney incompleta e hipertensión arterial en una mujer joven Incomplete Carney’s triad and arterial hypertension in a young woman

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    Alberto Allievi


    Full Text Available Se presenta una el caso de paciente joven, con tríada de Carney incompleta que cursa hipertensión arterial de dos años de evolución y anemia ferropénica grave por pérdida crónica de sangre por tubo digestivo, con tumores gástricos múltiples y paraganglioma pararrenal. No presenta aún desarrollo de condromas pulmonares visibles por tomografía axial computada. En nuestra paciente el paraganglioma no resultó funcionante. Resaltamos que la presencia de tumores gástricos múltiples en un adulto joven debe sugerir la posibilidad de tumores estromales (GIST, cuyo diagnóstico por biopsia endoscópica es difícil debido a su localización profunda, situada en las capas musculares de la pared gástrica. Asimismo queremos remarcar la importancia de las técnicas de marcación descriptas para el diagnóstico preciso. El seguimiento debe ser constante dado el pronóstico incierto de estos tumores. Los condromas pulmonares pueden aparecer años después de la resección del GIST y ser confundidos con metástasis del GIST.The case of young woman with arterial hypertension diagnosed two years before, is here presented; she had a ferropenic anemia caused by digestive loss of blood. Multiple gastric tumors and pararenal non functioning paraganglioma were found. No chondromas were detected. An incomplete Carney’s Triad was diagnosed. We remark that multiple gastric tumors in a young adult suggest the possibility of gastrointestinal stromal tumors (GIST Endoscopic biopsy frequently is not effective because these tumors are deep placed in the muscular gastric layers. The importance of specific techniques for a positive diagnosis are emphasized. Continuous follow up is needed because these tumors have uncertain prognosis. Lung chondromas may appear years later after the GIST was removed and might be confused with GIST metastases.

  9. Differential diagnosis of cystic bone tumors in childhood

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    Refior, H.J.; Stuerz, H.


    Skeletal changes leading to a suspicion of the presence of a tumour frequently occur in childhood with the roentgenological manifestation of a cyst. X-ray morphology can differ depending upon the localisation and the course. In childhood, however such findings are mainly classified as tumour-like bone lesions. This group comprises, inter alia, the juvenile bone cyst, the aneurysmatic bone cyst and fibrous dysplasia. However, it is necessary to exclude by differential diagnosis - even though the main age of manifestation is after completion of growth - genuine bone tumours with cystic phenomena, such as the giant cell tumour, chondroma or chondroblastoma. Verification of the diagnosis can be effected via radiologic-diagnostic methods such as tomography and angiography as well as computerized tomography. The use of scintigraphy of the skeleton can likewise be indicated. Numerous laboratory parameters can be used in individual cases to exclude certain diagnoses. Taking these aspects into consideration, the article reviews differential diagnosis of the most frequent skeletal affections in childhood. Great emphasis is given to the ranking and importance of the individual diagnostic methods.

  10. Bony sequestrum: A radiologic review

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    Jennin, Felicie; Bousson, Valerie; Parlier, Caroline; Jomaah, Nabil; Khanine, Vanessa; Laredo, Jean-Denis [Lariboisiere Hospital, Department of Radiology, Paris (France)


    According to a pathological definition, a bony sequestrum is defined as a piece of devitalized bone that has been separated from the surrounding bone during the process of necrosis. However, the radiological definition of a sequestrum is different and refers to an image of calcification visible within a lucent lesion, completely separated from the surrounding bone, without referring to the vascular status and histological nature of the calcified tissue. The term ''button sequestrum'' has been used in calvarial lesions. The prototype conditions that may present with a bony sequestrum are osteomyelitis and skeletal tuberculosis. Other conditions such as radiation necrosis, eosinophilic granuloma, metastatic carcinoma, primary lymphoma of bone, aggressive fibrous tumors may also manifest as osteolytic lesions containing a sequestrum. In addition, some primary bone tumors produce a matrix that may mineralize and sometimes simulate a bone sequestrum. These include osteoid tumors (osteoid osteoma, osteoblastoma), cartilaginous tumors (chondroma and chondroblastoma), lipomatous tumors (lipoma), and benign fibrous tumors (fibromyxoma, myxoma, and desmoplastic fibroma). Therefore, various conditions may present at imaging as a small area of osteolysis containing central calcifications. However, a careful analysis of the sequestrum as well as the associated clinical and radiological findings often enables to point toward a limited number of conditions. (orig.)

  11. Imaging tumors of the patella

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    Casadei, R., E-mail: [Department of Orthopaedic Oncology, Istituto Ortopedico Rizzoli, Bologna (Italy); Kreshak, J., E-mail: [Department of Orthopaedic Oncology, Istituto Ortopedico Rizzoli, Bologna (Italy); Department of Pathology, Istituto Ortopedico Rizzoli, Bologna (Italy); Rinaldi, R. [Department of Radiology, Istituto Ortopedico Rizzoli, Bologna (Italy); Rimondi, E., E-mail: [Department of Radiology, Istituto Ortopedico Rizzoli, Bologna (Italy); Bianchi, G., E-mail: [Department of Orthopaedic Oncology, Istituto Ortopedico Rizzoli, Bologna (Italy); Alberghini, M., E-mail: [Department of Pathology, Istituto Ortopedico Rizzoli, Bologna (Italy); Ruggieri, P. [Department of Orthopaedic Oncology, Istituto Ortopedico Rizzoli, Bologna (Italy); Vanel, D., E-mail: [Department of Radiology, Istituto Ortopedico Rizzoli, Bologna (Italy); Department of Pathology, Istituto Ortopedico Rizzoli, Bologna (Italy)


    Background: Patellar tumors are rare; only a few series have been described in the literature and radiographic diagnosis can be challenging. We reviewed all patellar tumors at one institution and reviewed the literature. Materials and methods: In an evaluation of the database at one institution from 1916 to 2009, 23,000 bone tumors were found. Of these, 41 involved the patella. All had imaging studies and microscopic diagnostic confirmation. All medical records, imaging studies, and pathology were reviewed. Results: There were 15 females and 26 males, ranging from 8 to 68 years old (average 30). There were 30 benign tumors; eight giant cell tumors, eight chondroblastomas, seven osteoid osteomas, two aneurysmal bone cysts, two ganglions, one each of chondroma, exostosis, and hemangioma. There were 11 malignant tumors: five hemangioendotheliomas, three metastases, one lymphoma, one plasmacytoma, and one angiosarcoma. Conclusion: Patellar tumors are rare and usually benign. As the patella is an apophysis, the most frequent lesions are giant cell tumor in the adult and chondroblastoma in children. Osteoid osteomas were frequent in our series and easily diagnosed. Metastases are the most frequent malignant diagnoses in the literature; in our series malignant vascular tumors were more common. These lesions are often easily analyzed on radiographs. CT and MR define better the cortex, soft tissue extension, and fluid levels. This study presents the imaging patterns of the more common patellar tumors in order to help the radiologist when confronted with a lesion in this location.

  12. Condromatosis sinovial de la articulación temporomandibular Synovial chondromatosis of the temporomandibular joint

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    P. Quirós Alvarez


    Full Text Available La afectación de la ATM por una condromatosis sinovial es un hecho muy poco frecuente. Trastorno metaplásico del tejido sinovial, suele producir cuerpos libres, condromas, intraarticulares. Tiene una clínica variable y muy inespecífica. Las pruebas diagnósticas de elección son la RM y la artroscopia. La retirada de cuerpos libres y sinovectomía parcial suele ser terapéutica. Ocasionalmente puede destruir la base del cráneo y extenderse intracranealmente. Se han descrito casos de malignización secundaria. Es necesario el seguimiento a largo plazo del paciente. Presentamos un caso con osteolisis incipiente de la fosa cerebral media.Synovial chondromatosis very rarely affects the TMJ. It is a metaplastic disorder of the synovial tissue that usually produces intra-articular loose bodies, or chondromas. It has variable clinical features and the symptoms are unspecific. Examination by means of magnetic resonance imaging and arthroscopic observation are the diagnostic techniques of choice. Treatment consists in the removal the loose bodies and partial synovectomy. Occasionally the skull has been destroyed and the middle cranial fossa invaded. There are cases of malignant transformation to chondrosarcoma. A long-term follow up is necessary. We describe a case with incipient intracranial extension.

  13. Evaluation of the lesions of synovial-lined clefts in the Hoffa's infrapatella fat pad with MR imaging

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    Kang, Min Sun; Park, Jin Gyoon; Kim, Young Cheol; Hwang, Eai Hong; Joo, Jung Hyun; Chung, Tae Woong; Kang, Heoung Keun [Chonnam Univ., College of Medicine, Kwangju (Korea, Republic of); Oh, Hee Yeon [Namkwang Hospital, Kwangju (Korea, Republic of)


    Within Hoffa's infrapatellar fat pad there are two synovial clefts, horizontal and vertical, which communicate with the intra-articular space. Intra-articular lesions can also occur in these clefts, and are often difficult to differentiate from extra-articular lesions. The purpose of this study is to evaluate, using MR imaging, the lesions occurring in these synovial lined clefts, as well as associated abnormalities. Thirty-one knees of 31 patients with lesions in horizontal and vertical clefts in Hoffa's infrapatellar fat pad were retrospectively evaluated. Using a 1.5T MR imager, axial, sagittal, and coronal MR images of knees were obtained. Lesions in clefts, degree of joint effusion and associated knee abnormalities were analyzed. Horizontal cleft lesions were noted in 21 cases; there were 17 cystic dilatations, two loose bodies, one synovial chondroma, and one case of pigmented villonodular synovitis(PVNS). Vertical cleft lesions were noted in 15 cases; these comprised 11 cystic dilatations, two loose bodies, one synovial osteochondromatosis, and one PVNS. Among all cases, three cystic dilatations, one loose body, and one PVNS occurred in both horizontal and vertical clefts. Among 25 knees with cystic dilatations of clefts, five showed grade 1, joint effusion, ten grade 2, and ten grade 3, Associated abnormalities were meniscal tear in 16 cases, osteoarthritis in 13, cruciate ligament tear in five, osteochondritis dissecans in three, osteochondral fracture in two, osteonecrosis in one, loose body in one, and synovitis in one. Among synovial-lined clefts in Hoffa's fat pad, the most common lesion was cystic dilatation;there were various associated abnormalities and a close relationship to joint effusion. An awareness of the types of lesions found in clefts is helpful for narrowing the differential diagnosis of lesions occurring in the area of Hoffa's fat pad.=20.

  14. Condrossarcoma laríngeo: relato de caso e revisão de literatura Laryngeal chondrosarcoma: a case report and review of literature

    Directory of Open Access Journals (Sweden)

    Giordania Gomes Campos


    Full Text Available Os tumores cartilaginosos da laringe são extremamente raros e correspondem a aproximadamente 1% dos tumores que acometem este órgão. Menos que 0,1% destes tumores correspondem aos condrossarcomas. Os condromas e os condrossarcomas de baixo grau são os mais freqüentemente encontrados e 70-75% destes tumores localizam-se na face laríngea da lâmina posterior da cartilagem cricóidea. O diagnóstico do condrossarcoma da laringe pode ser esquecido devido a sua baixa ocorrência e sua forma indolente de crescimento. A apresentação clínica é variada e diretamente dependente do tamanho e localização do tumor: estridor, cornagem, dispnéia, disfagia ou massa cervical são os sinais mais freqüentes. O objetivo deste estudo é apresentar um caso incomum de condrossarcoma laríngeo de origem na cartilagem tireóidea, discutindo o quadro clínico, o diagnóstico, tratamento e os fatores prognósticos.Cartilaginous tumors of the larynx are extremely rare neoplasms that account for approximately one per cent of all tumors of this organ. Less than 0.1% correspond to chondrosarcomas. Chondroma and low-grade chondrosarcoma are the most common, 70-75% of these tumors arise on the endolaryngeal surface of the posterior lamina of the cricoid cartilage. The diagnosis of laryngeal chondrosarcoma is likely to be missed because of its infrequent occurrence and its indolent pattern of growth. The clinical presentation is varied and directly dependent on size and location of tumor: stridor, hoarseness, dyspnea or neck mass are commonly presented signs. The objective of this study was to show an unusual case of laryngeal chondrosarcoma originating from thyroid cartilage, discussing its clinical presentation, diagnosis, treatment and prognosis.

  15. Molecular alterations and expression of succinate dehydrogenase complex in wild-type KIT/PDGFRA/BRAF gastrointestinal stromal tumors. (United States)

    Celestino, Ricardo; Lima, Jorge; Faustino, Alexandra; Vinagre, João; Máximo, Valdemar; Gouveia, António; Soares, Paula; Lopes, José Manuel


    Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract, disclosing somatic KIT, PDGFRA and BRAF mutations. Loss of function of succinate dehydrogenase (SDH) complex is an alternative molecular mechanism in GISTs, namely in carriers of germline mutations of the SDH complex that develop Carney-Stratakis dyad characterized by multifocal GISTs and multicentric paragangliomas (PGLs). We studied a series of 25 apparently sporadic primary wild-type (WT) KIT/PDGFRA/BRAF GISTs occurring in patients without personal or familial history of PGLs, re-evaluated clinicopathological features and analyzed molecular alterations and immunohistochemistry expression of SDH complex. As control, we used a series of well characterized 49 KIT/PDGFRA/BRAF-mutated GISTs. SDHB expression was absent in 20% and SDHB germline mutations were detected in 12% of WT GISTs. Germline SDHB mutations were significantly associated to younger age at diagnosis. A significant reduction in SDHB expression in WT GISTs was found when compared with KIT/PDGFRA/BRAF-mutated GISTs. No significant differences were found when comparing DOG-1 and c-KIT expression in WT, SDHB-mutated and KIT/PDGFRA/BRAF-mutated GISTs. Our results confirm the occurrence of germline SDH genes mutations in isolated, apparently sporadic WT GISTs. WT KIT/PDGFRA/BRAF GISTs without SDHB or SDHA/SDHB expression may correspond to Carney-Stratakis dyad or Carney triad. Most importantly, the possibility of PGLs (Carney-Stratakis dyad) and/or pulmonary chondroma (Carney triad) should be addressed in these patients and their kindred.

  16. Sinovite vilonodular pigmentada localizada: relato de caso Localized pigmented villonodular synovitis: case report

    Directory of Open Access Journals (Sweden)

    Fabiola Andrea de Carvalho Godoy


    Full Text Available O caso em questão é o de uma paciente do sexo feminino que apresentava queixa de dor na região anterior do joelho esquerdo durante e após atividades esportivas, seguidas de bloqueio articular havia três meses. Exames de imagem: radiografias simples do joelho normais e ressonância magnética mostrando formação expansiva sólida podendo corresponder a condroma de partes moles ou a sinovite nodular focal. Realizada ressecção artroscópica da lesão com diagnóstico de tumor de células gigantes difuso símile/sinovite vilonodular pigmentada localizada (SVNPL após resultado do exame anatomopatológico. A paciente apresenta boa evolução clínica com desaparecimento dos sintomas e retorno às atividades físicas.This case concerned a female patient with a complaint of pain in the anterior region of her left knee during and after sports activities, followed by joint blockage three months ago. From imaging examinations, simple radiography of the knee was normal and magnetic resonance showed a solid expansive mass, possibly corresponding to soft-tissue chondroma or focal nodular synovitis. Arthroscopic resection of the lesion was performed, and the diagnosis of diffuse giant cell tumor resembling localized pigmented villonodular synovitis (PVNS was made from the result of the anatomopathological examination. The patient presented good clinical evolution, with disappearance of symptoms and return to physical activities.

  17. Multiple endocrine neoplasias: advances and challenges for the future. (United States)

    Alevizaki, M; Stratakis, C A


    Several important advances have been made over the last 2 years, since the last international workshop on multiple endocrine neoplasias (MENs) that was held in Marseilles, France (MEN2006). The series of articles that are included in this issue summarize the most important of these advances as they were presented in Delphi, Greece, during the 11th International Workshop on MENs, September 25-27, 2008 (MEN2008). This editorial summarizes some of these advances: the identification of the AIP, and the PDE11A and PDE8B genes by genome-wide association (GWA) studies as predisposing genes for pituitary and adrenal tumours, respectively, the discovery of p27 mutations in a new form of MEN similar to MEN type 1 (MEN 1) that is now known as MEN 4, the molecular investigations of Carney triad (CT), a disorder that associates paragangliomas (PGLs), gastrointestinal stromal tumour (GISTs), and pulmonary chondromas (PCH) with pheochromocytomas and adrenocortical adenomas and other lesions, and the molecular elucidation of the association of GISTs with paragangliomas (Carney-Stratakis syndrome) that is now known to be because of SDHB, SDHC, and SDHD mutations. Molecular investigations in Carney complex (another MEN also described by Dr. Carney, who during the meeting, along with Dr. Charles E. ('Gene') Jackson was honoured for his life-long and many contributions to the field) have also revealed the role of cyclic AMP signalling in tumorigenesis. As our knowledge of the molecular causes of MENs increases, the challenge is to translate these discoveries in better treatments for our patients. Indeed, new advances in the preventive diagnosis and molecular treatment of MEN 1 and MEN 2, respectively, continued unabated, and an update on this front was also presented at MEN2008 and is included in this issue.

  18. Novel case of Trevor’s disease: Adult onset and later recurrence (United States)

    Khalsa, Amrit S; Kumar, Neil S; Chin, Matthew A; Lackman, Richard D


    Dysplasia epiphysealis hemimelica (DEH), or Trevor’s disease, is an osteocartilaginous epiphyseal overgrowth typically occurring in children. The literature reports 6 adult cases and none describe recurrence requiring additional procedures. We present a new-onset proximal tibial DEH in an adult recurring approximately 3 years after open excision. A 39-year-old female presented with a history of right knee pain, swelling, and instability. Physical examination revealed a firm proximal tibial mass. Computed tomography (CT) imaging showed an exophytic, lobulated, sclerotic mass involving the anterolateral margin of the lateral tibial plateau. Magnetic resonance imaging was suggestive of an osteochondroma. The patient underwent curettage of the lesion due to its periarticular location. Histology revealed benign and reactive bone and cartilage consistent with periosteal chondroma. Two and a half years later, the patient presented with a firm, palpable mass larger than the initial lesion. CT revealed a lateral tibial plateau sclerotic mass consistent with recurrent intra-articular DEH. A complete excision was performed and histology showed sclerotic bone with overlying cartilage consistent with exostosis. DEH is a rare epiphyseal osteocartilaginous outgrowth frequently occurring in the long bones of children less than 8 years old. DEH resembles an osteochondroma due to its pediatric presentation and similar histologic appearance. Adult-onset cases comprise less than 1% of reported cases. Recurrence rate after surgical intervention is unknown. Only 1 such case, occurring in a child, has been described. Clinicians contemplating operative treatment for DEH should note the potential for recurrence and consider complete excision. A follow-up period of several years may be warranted to identify recurrent lesions. PMID:28144583

  19. Increased PADI4 expression in blood and tissues of patients with malignant tumors

    Directory of Open Access Journals (Sweden)

    Zhao Yan


    Full Text Available Abstract Background Peptidylarginine deiminase type 4 (PAD4/PADI4 post-translationally converts peptidylarginine to citrulline. Recent studies suggest that PADI4 represses expression of p53-regulated genes via citrullination of histones at gene promoters. Methods Expression of PADI4 was investigated in various tumors and non-tumor tissues (n = 1673 as well as in A549, SKOV3 and U937 tumor cell lines by immunohistochemistry, real-time PCR, and western blot. Levels of PADI4 and citrullinated antithrombin (cAT were investigated in the blood of patients with various tumors by ELISA (n = 1121. Results Immunohistochemistry detected significant PADI4 expression in various malignancies including breast carcinomas, lung adenocarcinomas, hepatocellular carcinomas, esophageal squamous cancer cells, colorectal adenocarcinomas, renal cancer cells, ovarian adenocarcinomas, endometrial carcinomas, uterine adenocarcinomas, bladder carcinomas, chondromas, as well as other metastatic carcinomas. However, PADI4 expression was not observed in benign leiomyomas of stomach, uterine myomas, endometrial hyperplasias, cervical polyps, teratomas, hydatidiform moles, trophoblastic cell hyperplasias, hyroid adenomas, hemangiomas, lymph hyperplasias, schwannomas, neurofibromas, lipomas, and cavernous hemangiomas of the liver. Additionally, PADI4 expression was not detected in non-tumor tissues including cholecystitis, cervicitis and synovitis of osteoarthritis, except in certain acutely inflamed tissues such as in gastritis and appendicitis. Quantitative PCR and western blot analysis showed higher PADI4 expression in gastric adenocarcinomas, lung adenocarcinomas, hepatocellular carcinomas, esophageal squamous cell cancers and breast cancers (n = 5 for each disease than in the surrounding healthy tissues. Furthermore, western blot analysis detected PADI4 expression in cultured tumor cell lines. ELISA detected increased PADI4 and cAT levels in the blood of patients with

  20. Cartilage tumors. Pathology and radiomorphology; Chondrogene Knochentumoren. Pathologie und Radiomorphologie

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    Uhl, M. [RKK-Klinikum Freiburg, Klinik fuer Diagnostische und Interventionelle Radiologie, Kinderradiologie und Neuroradiologie SJK, Freiburg (Germany); Herget, G. [Universitaetsklinik Freiburg, Department Orthopaedie und Traumatologie, Freiburg (Germany); Kurz, P. [Universitaetsklinik Freiburg, Pathologisches Institut, Freiburg (Germany)


    Primary cartilage-forming tumors of the bone are frequent entities in the daily work of skeletal radiologists. This article describes the correlation of pathology and radiology in cartilage-forming skeletal tumors, in particular, enchondroma, osteochondroma, periosteal chondromas, chondroblastoma and various forms of chondrosarcoma. After reading, the radiologist should be able to deduce the different patterns of cartilage tumors on radiographs, CT, and MRI from the pathological aspects. Differentiation of enchondroma and chondrosarcoma is a frequent diagnostic challenge. Some imaging parameters, e. g., deep cortical scalloping (more than two thirds of the cortical thickness), cortical destruction, or a soft-tissue mass, are features of a sarcoma. Osteochondromas are bony protrusions with a continuous extension of bone marrow from the parent bone, the host cortical bone runs continuously from the osseous surface of the tumor into the shaft of the osteochondroma and the osteochondroma has a cartilage cap. Chondromyxoid fibromas are well-defined lytic and eccentric lesions of the metaphysis of the long bones, with nonspecific MRI findings. Chondroblastomas have a strong predilection for the epiphysis of long tubular bones and develop an intense perifocal bone marrow edema. Dedifferentiated chondrosarcomas are bimorphic lesions with a low-grade chondrogenic component and a high-grade noncartilaginous component. Most chondrogenic tumors have a predilection with regard to site and age at manifestation. (orig.) [German] Primaere knorpelbildende Tumoren sind haeufige Entitaeten in der taeglichen Arbeit des Radiologen. Der Beitrag beschreibt die Korrelation von Pathologie und Radiologie knorpelbildender Skeletttumoren, insbesondere von Enchondrom, Osteochondrom, periostalem Chondrom, Chondroblastom, und verschiedenen Varianten des Chondrosarkoms. Nach Lesen des Beitrags kann der Radiologe die verschiedenen typischen Muster knorpelbildender Tumoren im Roentgenbild

  1. Study in the effect of primary total knee arthroplasty for 108 knee arthroses%初次人工全膝关节表面置换术治疗膝关节骨关节病108例的疗效观察

    Institute of Scientific and Technical Information of China (English)

    区文欢; 陈述祥


    [Objective]To investigate the effect of primary total knee arthropl asty for knee arthrosis. [Method]Totally 108 cases (130 knees)of knee arthrosis were treated with primary total knee resurface arthroplasty. There were SO male patients (60 knees) ,58 female patiewts ( 70 knees) , their average age was 71. 5 years, ( 47 to 87 years) , preoperative diagnosis of the patients included 62 cases(70 knees)of osteoarthritis,37 cases(51 knees) of rhumatoid arthritis,4 cases of traumatic arthritis,2 cases of synoval chondroma ,2 cases of pivillian synovitis, 1 case of old tubercrosis. Eighty cases (92 knees) were treated by posterior stabilize prosthesis,28 cases(38 knees) by PCL restore prosthesis. [ Result] All 108 cases were followed up for 24 - 84 months, with 50.3 on average. All got pain relieves and function and range of motion(ROM) improved. According HSS scores,the scores were improved from 48.4 preoperatively to 89.3 postoperatively. The rang of motion(ROM) were 102° in average. Totally 126 knees got normal stress line recovery, while 3 got 6° ~ 8°varus, 1 got 15°valgus. The excellent to good rate were 90. 5%. [ Conclusion] Total knee resurface arthroplasty can provide satisfactory result in the treatment of knee arthrosis. Accurate osteotomy, prosthesis choice,proper soft tissue release to get soft tissue balance and correction of patellar tract are keys for this operation.%[目的]探讨初次人工全膝关节表面置换术(total knee arthroplasty,TKA)治疗膝关节病的临床疗效.[方法]对108例130个膝关节行TKA,男50例(60膝),女58例(70膝);年龄47~87岁,平均71.5岁,术前诊断骨性关节炎62例(70膝),类风湿性关节炎37例(51膝),创伤性关节炎4例,滑膜软骨瘤病2例,色素沉着绒毛结节性滑膜炎2例,陈旧关节结核1例,采用后方稳定假体80例(92膝),后交叉韧带保留假体28例(38膝).[结果]108例患者均获随访,时间24~84个月,平均50.3个月.患者术后在疼痛、功能、活动度

  2. 原发性气管肿瘤的呼吸介入治疗(附14例报告)%Interventional bronchoscopy therapy of primary tracheal tumors: report of 14 cases

    Institute of Scientific and Technical Information of China (English)

    张冬青; 陈成水; 叶民; 金旭如; 叶君如; 周颖


    tumors,especially appropriate indications and the role of interventional bronchoscopy.Methods:A retrospective analysis of the clinical data of 14 patients with primary tracheal tumors admitted to our department during the period of 2003 to 2009 was performed,all cases had detailed chest radiography,bronchoscopy and pathologic diagnosis.Results:Early clinical symptoms of all cases are unspecific,including cough and dyspnea.The majority malignant tumors included squamous cell carcinomas and adenoid cystic carcinomas; benign tumors consisted of pleiomorphic adenoma,leiomyoma,Chondroma,etc.Nine cases received surgery,and 5 of 9 received interventional bronchoscopic techniques at the same time; and the main therapy of another 5 cases were interventional bronchoscopic treatment.And the main interventional bronchoscopic techniques consisted of electrocoagulation and argon-beam coagulation.The main goal of interventional bronchoscopic treatment included benign tracheal tumors and keeping the airway open before sugery and as palliative therapy of advanced malignant tumors.Conclusion:Among primary tracheal tumors,we must pay more attention to the nonspecific symptoms.Surgery should be considered as the first choice of treatment,and interventional bronchoscopic techniques can be used in the diagnosis and provide treatment of endobronchial benign tumours,and as a way to keep the airway open until subsequent definitive resection can be done or as palliative therapy of unresectable malignant tumors.%目的:探讨原发性气管肿瘤的诊断和治疗方法,以及呼吸介入治疗的应用价值.方法:回顾性分析温州医科大学附属第一医院呼吸内科2003-2009年间原发性气管肿瘤14例的诊断和治疗经过.结果14例患者临床上均以不同程度的咳嗽、呼吸困难为主.病理组织学类型,恶性9例,以鳞癌、腺样囊性癌为主,良性肿瘤5例,包括:梭形细胞肿瘤、脂肪瘤和软骨瘤等.14例中9例患者接

  3. 颅底肿瘤术后再手术原因的分析(附14例报告)%Analysis the reasons of emergency reoperation after skull base surgery: report of 14 cases

    Institute of Scientific and Technical Information of China (English)

    郝淑煜; 薛湛; 李达; 肖新如; 汤劼; 王亮; 吴震; 张力伟; 张俊廷


    目的 探讨神经外科颅底肿瘤手术后急诊再次开颅手术病例的临床特征.方法 回顾性分析首都医科大学附属北京天坛医院神经外科2008年10月至2013年10月2 500例颅底手术病例中术后再次急诊开颅手术的14例患者,其中颅底脑膜瘤6例,神经鞘瘤3例,垂体腺瘤、颅咽管瘤、骨软骨瘤、血管平滑肌瘤、颈静脉球瘤各1例.第一次手术平均用时9.2h,术中平均出血2 750 ml.再手术的原因由术者和专家组分析得出,并由全科讨论确认.结果 再手术的14例患者中,9例表现为意识减弱,2例术后未能正常苏醒,2例术后常规CT检查发现异常,1例为突发性伤口出血.CT检查发现异常的平均时间为术后17 h,其中瘤腔内出血4例,脑内血肿伴脑挫裂伤4例,大面积脑梗死2例,脑内血肿合并硬膜下血肿l例,硬膜外血肿2例,椎动脉出血1例.再手术后恢复良好6例,中残2例,重残2例,植物生存1例,死亡3例.结论 对于行颅底肿瘤手术的患者,应加强围手术期管理,减少再次手术的发生.%Objective To report the clinical features of the patients who underwent emergent recraniotomy after skull base operation.Methods A serial of 14 cases of reoperation after elective surgery in the Department of Neurosurgery,Beijing Tiantan Hospital between October 2008 and October 2013 were reviewed.Six cases were skull basal meningioma,3 schwannoma,1 pituitary adenoma,1 craniopharyngioma,1 chondroma,1 angioleiomyoma,and 1 glomus jugular tumor.The mean length of first operation time was 9.2 h,and the mean amount of bleeding was 2 750 ml.The reason of reoperation was evaluated by the surgeons and experts,and then approved by all doctors.Results The clinical features of these reoperation patients included altered level of consciousness in 9 cases,unrecovered from anesthesia in two,abnormal CT scan in two and one sudden bleeding in wound.The mean time of abnormal CT scan was 17 h.As for the reason for

  4. Computed Radiography and Computed Tomography of Chest Wall Diseases%胸壁病变的计算机X线摄影和CT检查

    Institute of Scientific and Technical Information of China (English)

    洪庆坚; 李惠民; 肖湘生; 王晨光; 胡爱妹


    Purpose: To analyze computed radiography (CR) and computed tomography (CT) findings of diseases of chest wall and to investigate the value of CR and CT in diagnosis of these diseases. Materials and Methods: The findings and diagnoses of 39 cases with proved (by fina needle biopsy, or surgory and/or pathology, of clinical follow up) chest wall disease were analysed retrospectively. Resulte: In 12 infective lesions, including purulent infection (4 cases) and tuberculosis (8 cases), the correct dignosis was made in 4cases by CR and in 11 cases by CT. In 16 soft tissue tumors, including lipoma (7 cases), fibrosarcoma (4 cases), hemangioma (1 case), neurofibroma (1 case), malignant fibrous histocytoma (1case), aggressive fibromatosis (1 case) and liposarcoma (1 case), the correct diagnosis was made in 3cases by CR and in 14 cases by CT. In 11 bone lesions, including fibrous dysplasia (7 cases), chondroma (2 cases), myeloma (lcase) and cosinophilic granuloma (1 case), the correct diagnosis was made in 8cases by CR and in 10 cases by CT. Conclusion: CR is useful in the dignosis of chest wall bone diseases. CT is obviously superior to CR for demonstration of all chest wall diseases espacially for soft tissue lesions. CT has definite value for the differentiation of malignant from benign tumore of chest wall, but still has certain limit.%目的:探讨胸壁病变的计算机X线摄影(CR)和CT表现及其诊断价值,提高对胸壁病变的认识。材料和方法:回顾分析经手术病理、穿刺细胞学检查或临床随访资料证实的39例CR和CT资料。结果:感染组12例中(包括化脓性感染4例,胸壁结核8例),CR准确诊断4例,CT诊断11例;软组织肿瘤组16例中(包括脂肪瘤7例,纤维肉瘤4例,血管瘤、神经纤维瘤、恶性纤维组织细胞瘤、侵袭性纤维瘤病和脂肪肉瘤各l例),CR准确诊断3例,CT诊断14例;骨肿瘤和肿瘤样病变组11例中(包括骨纤维异常增殖症7例,软骨瘤2

  5. Comparative Analysis of CT and MRI Imaging Findings of Chondroblastoma%软骨母细胞瘤的CT及MRI影像表现对比分析

    Institute of Scientific and Technical Information of China (English)



    目的:比较软骨母细胞瘤的CT及MRI影像表现。方法纳入我院2011年1月-2015年12月期间共收集36例软骨母细胞瘤患者进行研究,均行CT及MRI检查,比较二者对软骨母细胞瘤临床诊断的价值。结果 CT表现以病灶边缘硬化、病灶内钙化、骨膜反应、软组织肿胀、邻近关节腔积液为主,增强扫描后病灶内均示轻度到中度强化,CT值增高8-34HU。MRI示病灶多为卵圆形或类圆形囊状骨质破坏区、边界清晰,T1WI低信号、T2WI高低混杂信号,特殊征象包括片状、斑点状低信号钙化或骨嵴、病灶边缘低信号硬化带、T2WI病灶周围骨髓腔见长T2水肿信号。两种检查方法对膨胀性病变、窗格样改变、骺板或骺线穿越等征象的检出率无统计学意义(P>0.05);CT对边界清晰伴边缘硬化、病灶内钙化检出率分别为61.1%、66.7%,高于MRI的36.1%、41.7%,对骨髓水肿检出率仅为2.8%,低于MRI的27.8%,差异均有统计学意义(P0.05); The detection rates of CT for clear boundary with marginal sclerosis and calcification within the lesions (61.1%, 66.7%) were higher than those of MRI (36.1%, 41.7%) while the detection rate for bone marrow edema (2.8%) was lower than that of MRI (27.8%) (P<0.05).Conclusions CT and MRI in the diagnosis of chondroblastoma have their own advantages and disadvantages. CT can better show marginal sclerosis and calcification within the lesions while is poorer in displaying bone marrow edema. In clinical diagnosis, it needs to be identified from bone giant cell tumor, chondrosarcoma and chondroma etc..

  6. Quantification of the magnetization-transfer contrast effect: can it yield additional information in differentiation of musculoskeletal lesions particularly in separation of benign from malignant lesions; Quantifizierung des Magnetization Transfer Contrast (MTC) Effektes durch Berechnung von MT-Quotienten: Ergeben sich Zusatzinformationen fuer die Differenzierung benigner und maligner Erkrankungen des Bewegungsapparates?

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    Vahlensieck, M.; Traeber, F.; Schild, H. [Radiologische Universitaetsklinik Bonn (Germany); Gieseke, J. [Philips Medizinsysteme (Germany)


    Purpose: To investigate the potential information of the amount of magnetization-transfer effect in musculoskeletal lesions and to compare MT ratios from benign and malignant musculoskeletal lesions. Material and Method: 49 patients with malignant tumors (3 osteosarcoma, 3 malignant fibrous histiocytoma, 4 chondrosarcoma, 2 Ewing sarcomas) and benign lesions (8 chondroma, 2 fibrous dysplasia, 3 osteoid-osteoma, 6 ganglion cyst, 3 cyst, 3 osteomyelitis, 4 tendinitis, 3 rotator cuff tear, 5 scar tissue) were scanned using routine MRI protocols including T{sub 1}- and T{sub 2}-weighted spin echo as well as T{sub 2}*-weighted gradient echo (FFE) sequences at 1.5 Tesla (ACS II, Philips Medical). Additionally MTC images were generated by combining the FFE sequence and the off-resonance MT technique (-1500 Hz off-resonance frequency, 1770 flip angle and 50 ms pulse duration). MT ratios were calculated as SI{sub o}-SI{sub m}/SI{sub o}. Results: The MT ratio of benign lesions was 26{+-}15%, that of malignant lesions was 22{+-}6%. The difference was statistically not significant. As expected muscle showed a high MT ratio of 50{+-}8%. Scar tissue demonstrated an MT ratio of 39{+-}16% which was significantly higher than the tumor MT ratios. Conclusion: MTC (MT ratios) failed to show significant differences between benign and malignant lesions as was expected due to basic differences in cellularity, rate of mitosis and chromatin content. MTC might however gain more importance in separating scar tissue from recurrent tumor in the future. (orig.) [German] Zielsetzung: Durch die Quantifizierung des Magnetization Transfer Contrastes sollte untersucht werden, ob sich Zusatzinformationen in der Magnetresonanztomographie des Stuetz- und Bewegungsapparates ergeben. Insbesondere sollte ermittelt werden, ob gut- und boesartige Laesionen unterschiedliche MT-Quotienten aufweisen. Material und Methode: 49 Patienten mit boesartigen Tumoren (3 Osteosarkom, 4 Chondrosarkom, 3 Malignes