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Sample records for chondroblastoma

  1. Metastatic chondroblastoma

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    Errol U. Hutagalung

    2001-03-01

    Full Text Available A case of chondroblastoma, which is a benign tumor of the bone, with distant metastases to the lung and abdominal wall is reported. The clinical course of the disease was progressive like that of malignant process. (Med J Indones 2001; 10:57-9Keywords : chondroblastoma, bone tumor

  2. Vertebral chondroblastoma

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    Ilaslan, Hakan; Sundaram, Murali [Department of Radiology, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905 (United States); Unni, Krishnan K. [Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905 (United States)

    2003-02-01

    To determine the age distribution, gender, incidence, and imaging findings of vertebral chondroblastoma, and to compare our series with findings from case reports in the world literature.Design and patients Case records and imaging findings of nine histologically documented vertebral chondroblastomas were retrospectively reviewed for patient age, gender, vertebral column location and level, morphology, matrix, edema, soft tissue mass, spinal canal invasion, and metastases. Our findings were compared with a total of nine patients identified from previous publications in the world literature. The histologic findings in our cases was re-reviewed for diagnosis and specifically for features of calcification and secondary aneurysmal bone cyst (ABC). Clinical follow-up was requested from referring institutions. Nine of 856 chondroblastomas arose in vertebrae (incidence 1.4%; thoracic 5, lumbar 1, cervical 2, sacral 1). There were six males and three females ranging in age from 5 to 41 years (mean 28 years). Satisfactory imaging from seven patients revealed the tumor to arise from the posterior elements in four and the body in three. All tumors were expansive, six of seven were aggressive, and the spinal canal was significantly narrowed by bone or soft tissue mass in six. In one patient canal invasion was minimal. Calcification was pronounced in two and subtle in four. The sole nonaggressive-appearing tumor was heavily mineralized. Bony edema and secondary ABC were not seen on MR imaging. None of the cases had microscopic features of significant secondary ABC. Calcification, and specifically ''chicken wire'' calcification, was identified in two patients. Pulmonary metastases occurred in none. Vertebral chondroblastoma is a rare neoplasm that presents later in life than its appendicular counterpart. On imaging it is aggressive in appearance with bone destruction, soft tissue mass, and spinal canal invasion. The lesions contain variable amounts of mineral

  3. Chondroblastoma arising from acromion

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    WANG Min; ZHOU Yue; REN Xian-jun; ZHANG Xia; WANG Jian

    2005-01-01

    @@ Chondroblastoma is an uncommon benign tumor arising in the epiphysis of long bones such as humerus, tibia and femur while the skeletal or extraskeletal presentations are mostly unusual. The chondroblastoma arising from acromion process of scapulus has been extremely rare and only two cases can be screened out in the English literature[1,2]. Here, we reported another case of chondroblastoma that developed on the acromion of scapulus.

  4. Bone scintigraphy in chondroblastoma

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    Humphry, A.; Gilday, D.L.; Brown, R.G.

    1980-11-01

    Scintigraphy in 3 patients with chondroblastoma showed that the tumors were hyperemic and avidly accumulated the radionuclide. These changes were also present in adjacent normal bone, but to a lesser degree. This suggests that radionuclide uptake in chondroblastoma is a function of the blood supply to the tumor rather than primary matrix extraction.

  5. Chondroblastoma of temporal bone

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    Tanohta, K.; Noda, M.; Katoh, H.; Okazaki, A.; Sugiyama, S.; Maehara, T.; Onishi, S.; Tanida, T.

    1986-07-01

    The case of a 55-year-old female with chondroblastoma arising from the left temporal bone is presented. Although 10 cases of temporal chondroblastoma have been reported, this is the first in which plain radiography, pluridirectional tomography, computed tomography (CT) and angiography were performed. We discuss the clinical and radiological aspects of this rare tumor.

  6. Chondroblastoma of the talus.

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    Ningegowda, Ravish V; Subramanian, Karthik; Suresh, I

    2013-01-01

    We report the case of a 13-year-old male child who presented with a painful left ankle. On imaging (radiography and computed tomography scan with 3-dimensional reconstruction views), an osteolytic lesion in the body of the talus was revealed. Open biopsy, curettage, and fibular bone grafting were done, and the specimen was sent for histopathologic examination. The histopathologic report confirmed the specimen to be chondroblastoma of the talus bone. Chondroblastoma is a rare benign cartilaginous neoplasm that accounts for approximately 1% of all bone tumors and characteristically arises in the epiphysis of a long bone, particularly the humerus, tibia, and femur. Chondroblastoma can affect people of all ages. It is, however, most common in children and young adults aged 10 to 20 years. Chondroblastoma in a tarsal bone is a rare entity. Managing chondroblastoma of the talus with curettage and bone grafting has shown good outcomes.

  7. Chondroblastoma and chondromyxoid fibroma.

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    De Mattos, Camila B R; Angsanuntsukh, Chanika; Arkader, Alexandre; Dormans, John P

    2013-04-01

    Chondroblastoma and chondromyxoid fibroma are benign but locally aggressive bone tumors. Chondroblastoma, a destructive lesion with a thin radiodense border, is usually seen in the epiphysis of long bones. Chondromyxoid fibroma presents as a bigger, lucent, loculated lesion with a sharp sclerotic margin in the metaphysis of long bones. Although uncommon, these tumors can be challenging to manage. They share similarities in pathology that could be related to their histogenic similarity. Very rarely, chondroblastoma may lead to lung metastases; however, the mechanism is not well understood.

  8. Chondroblastoma of the triquetrum.

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    Wu, Chen-Te; Chen, Alvin Chao-Yu; Wang, Chao-Jan; Wang, Chih-Wei; Fu, Chen-Ju; Wong, Yon-Cheong

    2013-08-01

    Chondroblastoma is a relatively uncommon but benign bone tumor that is typically found in a long-bone epiphysis. Reports of this type of tumor in the carpals have been rare, and even fewer cases of such tumors in the triquetrum have been reported. Here, we present classical findings of a chondroblastoma at an unusual location, the triquetrum, in an adolescent. Fat-suppressed T2*-weighted imaging revealed a hyperintense tumor matrix replacing the bony trabecula of the triquetrum, which had not been addressed in previous literature. Radiography-based differential diagnosis of a bubbly lesion in the hand of an adolescent, even in the small carpal bones, should include chondroblastoma.

  9. Temporal Bone Localized Chondroblastoma.

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    Demirhan, Hasan; Acioğlu, Engin; Durna, Yusuf Muhammed; Yiğit, Özgür; Bozkurt, Erol Rüştü; Karagöz, Yeşim

    2015-11-01

    Chondroblastoma is a highly destructive tumor originating from immature cartilage cells. Although chondroblastoma is defined as a benign tumor, it may exhibit malign tumor behaviors such as invasion or metastasis on neighboring structures. Magnetic resonance (MR) image is a solid mass lesion, which included heterogeneous hypointense in T2A and heterogeneous minimal hyperintense in T1A with destructive expansile characteristics and millimetric calcifications. Temporal bone chondroblastomas may complicate the diagnosis because of their different histologic characteristics. Microscopically, chondroblastic cell nests and calcification of locally "chicken wire" type around the cells are observed. These tumors secrete s-100 and vimentin and are used for differential diagnosis. In this study, a temporal bone localized chondroblastoma case is presented.

  10. Chondroblastoma of the foot.

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    Fink, B R; Temple, H T; Chiricosta, F M; Mizel, M S; Murphey, M D

    1997-04-01

    A total of 322 cases of chondroblastoma were referred to the Armed Forces Institute of Pathology between 1960 and 1990. Ten additional cases of chondroblastoma were treated at Walter Reed Army Medical Center between 1985 and 1993. Forty-two of these involved the foot, two of which were treated at Walter Reed Army Medical Center. Patients with chondroblastoma of the foot were male in 35 (81%) cases, with a mean age of 25.5 years, which was significantly different from the mean age of 17.3 years in patients with chondroblastoma of the long bones (P Chondroblastoma of the foot is most commonly found in the posterior subchondral areas of the talus and calcaneus as well as in the calcaneal apophysis. Radiographically, the lesion was associated with an articular surface or apophyseal area in all cases and appeared radiolucent, with little to no matrix production. The margins were generally well defined. Cystic features were noted grossly and histologically in 24 (57%) specimens, a feature seen in only 21% of all chondroblastomas overall. Treatment consists of thorough curetting and bone grafting with good oncologic and functional results.

  11. Chondroblastoma of rib : case report

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    Kim, Dong Hun; Kim, Kyung Rae; Ryu, Sang Wan [Kwangju Hospital, Kwangju (Korea, Republic of)

    2004-07-01

    Chondroblastoma is an uncommon, benign, cartilaginous neoplasm originating in an epiphysis or apophysis of a long tubular bone. The rib is an unusual site for chondroblastoma. The authors describe a case of chondroblastoma of the rib and present a brief review of the literature.

  12. Inflammatory reaction in chondroblastoma

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    Yamamura, Sigeki [Dept. of Orthopedic Surgery, Nagoya Univ. School of Medicine (Japan); Sato, Keiji [Dept. of Orthopedic Surgery, Nagoya Univ. School of Medicine (Japan); Sugiura, Hideshi [Dept. of Orthopedic Surgery, Nagoya Univ. School of Medicine (Japan); Iwata, Hisashi [Dept. of Orthopedic Surgery, Nagoya Univ. School of Medicine (Japan)

    1996-05-01

    The objective of this study was to evaluate the inflammatory reaction accompanying chondroblastoma and to define the value of the finding in clinical practice. We reviewed the clinical, radiographic, and magnetic resonance (MR) findings in six patients with histologically proven chondroblastoma. In all cases, MR imaging showered marrow and soft tissue edema. In four of six cases, periosteal reaction related to intra-osseous edema was more clearly demonstrated on MR imaging than on radiographs. Follow-up MR studies after surgery were available in three patients and all showed disappearance of inflammatory responses such as marrow and soft tissue edema, and reactive synovitis. We propose that these inflammatory reactions of chondroblastomas are inportant signs for detecting residual tumor in recurrences after surgery, as well as for making a precise diagnosis. The MR changes may also be valuable in demonstrating eradication of the tumor. (orig./MG)

  13. Case report 537: Chondroblastoma

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    Pignatti, G.; Nigrisoli, M.

    1989-05-01

    A case is reported of a 10-year-old girl who presented with pain in the left hip. Radiologically, a well-defined lytic lesion with a sclerotic border was present in the neck of the femur, with no epiphyseal involvement. The rarity of a metaphyseal site of origin of a chondroblastoma was stressed and the literature reviewed. (orig./GDG).

  14. Chondroblastoma of the lumbar vertebra

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    Leung, L.Y.J.; Shu, S.J.; Chan, M.K.; Chan, C.H.S. [Dept. of Radiology and Imaging, Queen Elizabeth Hospital, Hong Kong (Hong Kong)

    2001-12-01

    Chondroblastoma of the vertebra is a very rare condition. To our knowledge fewer than 20 cases have been reported in the world literature. We report a 54-year-old man with chondroblastoma of the fifth lumbar vertebra. The clinical and radiological aspects of the tumor are discussed, emphasizing the presence of an extraosseous mass suggestive of locally aggressive behavior. (orig.)

  15. [Chondroblastoma--current opinion].

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    Vukasinović, Zoran; Spasovski, Dusko; Slavković, Nemanja; Slavković, Slobodan; Zivković, Zorica

    2006-01-01

    Chondroblastoma of bone is rare bone tumor, representing around 1% of benign bone lesions. It is considered a benign lesion, although primary malignant form as well as malignant alteration in the form of chondrosarcoma has been documented. It occurs predominantly in the second decade, more commonly in males. Predilection sites include proximal humeral epiphysis, femoral and tibial condyles, but it can be found in other bones, too (skull, pelvis, posterior vertebral structures, tarsal bones). Radiographically, it appears as an ovoid lesion with thin sclerotic margin, located centrally in the epiphysis. Pathohistologically, it is described as highly cellular tissue, variably differentiated and with discrete granulated to meshy calcification of the matrix and large multinuclear cells present in 20% of cases. Secondary formation of aneurysmal bone cyst has been documented. Tumor is presented with a few nonspecific local symptoms, which makes diagnostic procedure more difficult. Definitive diagnosis is made only by pathohistological verification. A pathological fracture of weakened epiphysis is possible. The treatment of chondroblastoma is strictly surgical, with a view to counteract the propagation into the joint or adjacent soft tissue, and diminish the recurrence rate. Chemotherapy is not indicated for treatment of this tumor, and radiotherapy is contraindicated as it stimulates malignant alteration. If malignant chondroblastoma of bone is verified pathohistologically, radical treatment by surgical resection is indicated, also avoiding any adjuvant therapy.

  16. Malignant chondroblastoma of extraskeletal origin.

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    Duttaluri, Ramu; Sultanpurkar, Guru Prasad; Raorane, Harshvardhan; Vikram, Harsha

    2016-01-01

    Chondroblastoma is a rare benign neoplasm of cartilaginous origin. It typically arises in the epiphysis of a long bone. They occur mostly in the second decade of life and is more common in males. Extraskeletal origin of chondroblastoma is a rarity and virulent behavior by its local aggressive nature or metastasis is reported in very few cases. We hereby, present a case of chondroblastoma in the left popliteal fossa first of its kind in a 62-year-old female, primary tumor extraskeletal in origin which turned locally aggressive and eventually metastasized to lungs. The patient is now on palliative therapy.

  17. Radiological evaluation of chondroblastoma

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    Hudson, T.M.; Hawkins, I.F. Jr.

    1981-04-01

    Eleven new and six recurrent chondroblastomas were studied with multiple radiological imaging methods (plain radiography, conventional tomography, computed tomography, radionuclide bone scanning, and angiography). When the plain radiographic appearance was typical, conventional tomography or computed tomography (CT) was helpful, but other studies were not. Periosteal reaction and angiographic hypervascularity were common and did not indicate cortical breakthrough. For large, aggressive, or atypical lesions, conventional tomography and CT were helpful in delineating anatomic extent, and angiography was of value in demonstrating major vessel displacement. Radionuclide bone scanning was not useful.

  18. [Giant chondroblastoma of the femur].

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    Zaspa, O A

    2014-01-01

    Chondroblastoma is a benign cartilaginous bone tumor. The large dimension and aggressive local spread of the tumor may create a diagnostic problem. A 24 x 17 x 15-cm chondroblastoma is described in a 50 year-old woman. The tumor of typical structure was located in the upper femur, growing into soft tissues and pelvic bones. Thirteen months following interilioabdominal exarticulation, the patient was found to have neither local recurrence nor distant metastases.

  19. Chondroblastoma of the navicular bone.

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    Li, Xiao Na; Peng, Zhi Gang; Zhao, Jing Pin; Zhang, Ze Kun

    2014-12-01

    This is a case report of a 24-year-old man who presented with increased pain and firm swelling of the right foot after a minor twisting injury. Radiography, computed tomography (CT) and magnetic resonance imaging (MRI) findings showed ancillary information that was helpful for surgical treatment. The final diagnosis was confirmed as chondroblastoma of the navicular bone based on the pathology report. The navicularbone is a very rare site in the foot, where we should pay attention to chondroblastoma.

  20. Chondroblastoma of the sphenoid bone

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    Patrocíni, Tomas Gomes

    2008-12-01

    Full Text Available Introduction: Chondroblastoma is an uncommon cartilaginous benign neoplasm, highly destructive, which specifically appears in the epiphysis of long bones in young patients. Its occurrence is extremely rare in the cranial base, normally occurring in the temporal bone. Objective: To describe a rare case in a patient presenting with a sphenoid bone chondroblastoma that invaded the middle cranial cavity, submitted to a successful surgical resection, without recurrence after 2 years. Case Report: W.J.S, 37 years old, male, forwarded to the otorhinolaryngology service with persistent and strong otalgia for 3 months. He had normal otoscopy and without visible tumorations. The computerized tomography confirmed tumor mass in the left infra-temporal cavity, invading the middle cranial cavity. The biopsy suggested giant cells tumor. After wide resection by frontal approach via orbitozygomatic osteotomy. During the surgery, we confirmed tomographic statements and didn't find temporal bone involvement. The histopathological exam confirmed chondroblastoma. After 18 months after the surgery, he doesn't present with complaints, without motor, sensitive deficits or of cranial nerves and without recurrence tomographic signals. Conclusion: The importance of differential diagnosis of chondroblastoma is remarkable in the cranial base lesions and its therapeutic approach, whose objective must always be the major possible resection with the maximum function conservation.

  1. Chondroblastoma of the distal phalanx.

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    Gregory, James R; Lehman, Thomas P; White, Jeremy R; Fung, Kar-Ming

    2014-05-01

    Chondroblastoma is a rare, benign primary bone tumor that usually occurs at the epiphysis of long bones. The authors present an example of the diagnosis and successful treatment of this neoplasm in an exceedingly rare location in the distal phalanx. Clinical and radiographic outcomes after 68 months of follow-up are presented. A 15-year-old, right hand-dominant, boy developed painful swelling of the right ring finger. Radiographs revealed a radiolucent lesion of the distal phalanx with expansile remodeling of the bone. An excisional biopsy was performed with curettage and bone grafting of the lesion. The diagnosis of chondroblastoma was made based on pathologic evaluation of the biopsy specimen. Sixty-six months after surgical treatment, the patient was free of recurrence and metastatic disease with excellent clinical and functional outcomes. To the authors' knowledge, this represents only the second reported case of chondroblastoma of the distal phalanx. The diagnosis of chondroblastoma in this rare location was made by pathologic review of the resection specimen. It is imperative to confirm the diagnosis of any resected bone specimen even when the concern for an aggressive or malignant lesion is low. A tumor presenting in an unusual location may require a change in treatment or surveillance.

  2. Chondroblastoma of the scaphoid: A case report

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    Sandeep Vijayan

    2015-01-01

    Full Text Available Benign Chondroblastoma generally occur in the epiphysis of long bones and rarely arise in carpal bones. We report a young male with chondroblastoma of scaphoid treated with curettage, bone grafting and K-wire fixation. At the last follow-up, 4 years after surgery, the patient was asymptomatic without recurrence.

  3. Chondroblastoma of the scaphoid: A case report.

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    Vijayan, Sandeep; Bhat, Anil K; Hameed, Shamsi Abdul; Kumar, Bhaskarananda

    2015-01-01

    Benign Chondroblastoma generally occur in the epiphysis of long bones and rarely arise in carpal bones. We report a young male with chondroblastoma of scaphoid treated with curettage, bone grafting and K-wire fixation. At the last follow-up, 4 years after surgery, the patient was asymptomatic without recurrence.

  4. Benign chondroblastoma - malignant radiological appearances

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    Schulze, K.; Treugut, H.; Mueller, G.E.

    1980-04-01

    The very rare benign chondroblastoma occasionally invades soft tissues and may grow beyond the epiphysis into the metaphysis. In the present case such a tumour did not show the typical radiological appearances, but presented malignant features both on plain films and on the angiogram. The importance of biopsy of tumours which cannot be identified with certainty must be stressed before radical surgery is carried out.

  5. Review of thirty patients with bone chondroblastoma

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    Slavković Slobodan

    2005-01-01

    Full Text Available Background/Aim. To analyse the results of the treatment of the patients with the diagnosis of chondroblastoma, to confirm the possible malignancy and to recommend the best and the safest method of the treatment. Methods. We reviewed the cases of 30 patients with chondroblastoma who were treated between 1975 and 2004. Data were obtained using complete medical documentation, physical examinations, radiographic findings, and the available additional diagnostic procedures. Results. We found that the proximal part of the tibia, proximal part of the humerus, and distal part of the femur were the most common sites of the tumor in 63% of the cases. The higher prevalence of chondroblastoma in male patients was found, especially in the second decade of life. The patients were treated with different surgical procedures after histologically confirmed chondroblastoma. In 1 of the patients, radiation therapy was performed because the lesion recurred, after which the malignant transformation of chondroblastoma occurred. We found two more malignant chondroblastomas, one of which had been diagnosed as a primary tumor. Seven patients had a local recurrence, one of them had a second recurrence and the malignant transformation of chondroblastoma. The only solution was a below knee amputation. Conclusion. Chondroblastoma of bone is a rare lesion with the high local recurrence rate. We emphasized the need for an adequate and rapid diagnosis, including histological verification. The treatment was strictly surgical. The basic goal of the treatment was to avoid tumor penetration into articular cavity and/or local soft tissues. Malignant chondroblastoma of bone should be treated with radical surgical resection, avoiding any adjuvant therapy.

  6. Atypical giant chondroblastoma mimicking a chondrosarcoma.

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    Dhanda, Sunita; Menon, Santosh; Gulia, Ashish

    2015-01-01

    Chondroblastoma is a rare, benign tumor derived from chondroblasts, commonly presenting in the second decade of life. It is usually found in the epiphysis or apophysis of long bones; however, it may rarely affect flat bones like scapula. Occasionally a histologically typical chondroblastoma may exhibit an aggressive behavior that is not normally associated with benign tumors such as a large size, pulmonary metastases, joint and soft-tissue infiltration and local recurrence. We present a case report of a patient with chondroblastoma showing atypical radiological presentation and non-concordance with age.

  7. Chondroblastoma of the temporal bone

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    Kobayashi, Yuko; Murakami, Ryusuke; Toba, Masahiro; Ichikawa, Taro [Dept. of Radiology, Nippon Medical School, Tokyo (Japan); Kanazawa, Ryuzaburo; Sanno, Naoko; Shimura, Toshiro [Dept. of Neurosurgery, Nippon Medical School, Tokyo (Japan); Sawada, Namie; Hosone, Masaru [Dept. of Pathology, Nippon Medical School, Tokyo (Japan); Kumazaki, Tatsuo [Dept. of Radiology, Nippon Medical School, Tokyo (Japan)

    2001-12-01

    A rare case of chondroblastoma arising from the temporal bone that occurred in a 60-year-old woman is reported. The tumor appeared well demarcated and osteolytic on the radiographs. CT scan clearly depicted marginal and central calcification in the tumor. MR imaging demonstrated two components in the tumor: a solid component with predominantly low signal intensities on both T1- and T2-weighted sequences, and a multilocular cystic component with T1- and T2-elongation and fluid-fluid levels on the T2-weighted images. Postcontrast MR imaging revealed marked enhancement in the solid component and the septa of the cystic component. (orig.)

  8. A guise of osteosarcoma: Chondroblastoma-like

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    Aditi Amit Byatnal

    2013-01-01

    Full Text Available Osteosarcoma (OS is a rare tumor arising from immature bone forming cells or through neoplastic differentiation of other immature mesenchymal cells into osteoblasts. Chondroblastoma-like OS is one of the rare forms of OS to be seen in jaw bones. Aggressive clinical behavior, osteolytic areas in the radiograph and histological presentation of chondroblastoma such as cells with grooved nuclei, typical chicken-wire calcification along with areas of tumor osteoid, implied the diagnosis as chondroblastoma-like OS. Use of reticulin stain further confirmed the diagnosis. A case of chondroblastoma-like OS is reported, emphasizing the importance of early diagnosis of aggressive jaw lesions with the help of routine radiography, histopathology, and special stains.

  9. A guise of osteosarcoma: chondroblastoma-like.

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    Byatnal, Aditi Amit; Rao, Anuradha C K; Solomon, Monica C; Radhakrishnan, Raghu A

    2013-01-01

    Osteosarcoma (OS) is a rare tumor arising from immature bone forming cells or through neoplastic differentiation of other immature mesenchymal cells into osteoblasts. Chondroblastoma-like OS is one of the rare forms of OS to be seen in jaw bones. Aggressive clinical behavior, osteolytic areas in the radiograph and histological presentation of chondroblastoma such as cells with grooved nuclei, typical chicken-wire calcification along with areas of tumor osteoid, implied the diagnosis as chondroblastoma-like OS. Use of reticulin stain further confirmed the diagnosis. A case of chondroblastoma-like OS is reported, emphasizing the importance of early diagnosis of aggressive jaw lesions with the help of routine radiography, histopathology, and special stains.

  10. Malignant Chondroblastoma of the Os Calcis

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    Emil M. Elek

    1998-01-01

    Full Text Available Patient. We describe a case of chondroblastoma of the os calcis which metastasized to the tibia, soft tissues and lung. A complete response of the lung lesions was noted with chemotherapy.

  11. [Diagnosis and treatment of patellar chondroblastoma].

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    Cheng, Qiang; Huang, Wei

    2013-12-01

    Chondroblastoma of the patella, rare occurred in patellar,is a kind of an uncommon benign bone tumor. Compared with giant cell tumor, the morbidity of chondroblastoma is lower. Meanwhile, its clinical manifestations are various, and images are very complicated. Therefore, the understanding of this kind of tumors may be limited even to the orthopedist. The differences of patellar chondroblastoma between other tumor in X-ray, CT and MRI is a spot in recent years. Sometimes patellar chondroblastoma coexists with aneurysmal bone cyst, which is a challenge to obtain an accurate pathological and radiological diagnosis. For the treatment, curettage and bone grafting is one the most popular method, but whether to perform a biopsy before surgery still remain controversy. Some new technique still has an unknown prospect for the treatment such as radiofrequency ablation.

  12. Chondroblastoma with Secondary Aneurysmal Bone Cyst

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    2008-02-01

    dysplasia, chondroblastoma, chondromyxoid fibroma , osteochondroma, giant cell tumors, or enchondroma. Chondrosarcoma, osteoblastoma–aggressive variant and...mass appears lobulated with scalloped cortical margins. Calcifications and cysts are often described.2,3,5 Chondromyxoid fibromas present in the

  13. Radiofrequency ablation of two femoral head chondroblastomas

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    Petsas, Theodore [Department of Radiology, University of Patras (Greece); Megas, Panagiotis [Department of Orthopaedic Surgery, University of Patras (Greece)]. E-mail: panmegas@med.upatras.gr; Papathanassiou, Zafiria [Department of Radiology, University of Patras (Greece)

    2007-07-15

    Chondroblastoma is a rare benign cartilaginous bone tumor. Surgical resection is the treatment of choice for pain relief and prevention of further growth. Open surgical techniques are associated with complications, particularly when the tumors are located in deep anatomical sites. The authors performed RF ablation in two cases of subarticular femoral head chondroblastomas and emphasize its positive impact. The clinical course, the radiological findings and the post treatment results are discussed.

  14. Chondroblastoma of the talus: a case report and literature review.

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    Zhang, Kairui; Gao, Yuan; Dai, Haifei; Zhang, Sheng; Li, Gong; Yu, Bin

    2012-01-01

    Chondroblastoma is a rare, benign cartilaginous neoplasm that accounts for approximately 1% of all bone tumors, and approximately 4% of all chondroblastomas arise in the talus. Here we report a case of chondroblastoma in the left talus. The 22-year-old male patient presented with a 16-month history of ankle pain. Based on radiological and pathological examination, we diagnosed the patient with chondroblastoma. A posterolateral approach was used to allow access to the lesion. After curettage, the allogenic bone chips were packed into the talar body defect. After 2 years' follow-up, we found no recurrence or metastasis of chondroblastoma, suggesting our surgery procedure was effective.

  15. Chondroblastoma of rib in situs inversus

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    Purwa R Patil

    2014-01-01

    Full Text Available Chondroblastoma is a rare benign cartilaginous tumour accounting for approximately 1% of all bone tumours. It commonly arises from epiphysis of a long bone, particularly the humerus, tibia and femur. Rib is an extremely rare site for this tumour with a few cases reported in the literature. It is commonly seen in children and adults between the ages of 10 - 20 years. Although roentgenographic findings are quite common characteristic of this tumour, it can sometimes be misdiagnosed as giant cell tumour, osteogenic sarcoma and myeloma on histopathology. We report a 26-year-old male patient with situs inversus and chondroblastoma of rib. To the best of our knowledge, this is the first case of chondroblastoma of the rib in a patient of situs inversus. Segmental resection is the treatment of choice. It usually behaves in a benign fashion, but few cases have shown local recurrences and distant metastasis; hence, follow-up of the patient is essential.

  16. About one case of vertebral chondroblastoma

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    Hoeffel, J.C.; Brasse, F.; Marchall, A.L.; Schmitt, M.; Plenat, F.; Vignaud, J.M.; Czorny, A.; Montaut, J.

    1987-07-01

    The authors report the case of a 9-year-old child which suffered from a chondroblastoma of the cervical spine. He had clinical signs of superior mediastinum compression with inflammation of the respiratory upper air-way. Surgery was performed. Diagnosis was established by the pathologist. The recurrence one year later was treated again by surgery and also by radiotherapy. Another recurrence four years later was fatal. The difficulties of the diagnosis and the appearance of recurrences in some cases of chondroblastoma are reviewed in the literature.

  17. Chondroblastoma

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    ... 25 years old. The tumors are very rare, accounting for only about 1 percent of all bone ... Orthop Surg 2013; 21: 225-233. Computerized tomography (CT) scans. More detailed than a plain x-ray, ...

  18. Aneurysmal Bone Cyst: An Uncommon Secondary Event in Calcaneal Chondroblastoma.

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    Barman, Sandip; Diwaker, Preeti; Bansal, Divya; Wadhwa, Neelam; Singh, Gurvinder

    2016-06-01

    Chondroblastoma is an uncommon benign bone tumour, involvement of epiphysis of long bones is typical. Chondroblastoma of the calcaneum is uncommon and its association with secondary aneurysmal bone cyst is even rarer. Only two cases of calcaneal chondroblastoma associated with secondary aneurysmal bone cyst have been reported till date. A 22-year-old male presented to the department of orthopaedics with complains of pain and swelling in the left heel since the last 10 months. On clinico-radiological grounds differentials considered were giant cell tumour of bone and aneurysmal bone cyst. In view of the histopathological findings of bone curettage and results of special stain and immunohistochemical marker, final diagnosis of chondroblastoma with secondary aneurysmal bone cyst, left calcaneum was rendered. Although rare, chondroblastoma should always be considered in osteolytic lesions of calcaneum. The identification of secondary aneurysmal bone cyst component is important as it has higher chances of recurrence than usual chondroblastoma.

  19. A fatal case of pure metaphyseal chondroblastoma.

    Science.gov (United States)

    Binesh, Fariba; Moghadam, Reza Nafisi; Abrisham, Jalil

    2013-08-23

    The chondroblastoma (CB) is a rare cartilaginous tumour; it represents less than 1% of all bone tumours. It is mostly localised at the level of the epiphysis of long bones. We report a fatal case of pure metaphyseal CB of the tibia in a 9-year-old boy whose pulmonary metastases developed soon after operative therapy of the primary tumour.

  20. Skull base chondroblastoma : a case report.

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    Moorthy R

    2002-10-01

    Full Text Available Chondroblastoma is a rare tumor of the skull. Temporal bone is the commonest site of involvement in the skull. We present a thirty one year old man who presented with painless swelling over the left temporal bone, which was near totally excised after preoperative embolization. Management of this unusual tumor and its complications are discussed.

  1. Diagnosis and treatment of chondroblastoma: Our experience

    Directory of Open Access Journals (Sweden)

    Slavković Slobodan

    2006-01-01

    Full Text Available The paper presented the results of diagnostics and treatment of patients with diagnosis of chondroblastoma, treated at the Institute of Orthopedic Surgery "Banjica", Belgrade. A total of 30 patients were analyzed, involving the period from 1975-2004. All important data were obtained using the complete medical documentation, physical examination, radiographic findings and available additional diagnostic procedures. The proximal part of tibia, the proximal part of humerus and the distal part of femur were the most common sites of tumor, accounting for 63% of cases. Higher incidence of chondroblastoma was found in male patients, especially in the second decade of life. Pathohistological tumor verification was done in all patients. The patients were then treated by different surgical procedures, both on account of primary lesion and recurrence. Curettage and osteoplasty using the auto- and homograft were carried out in 21 patients, wide resection in nine cases, and amputation was performed in three cases. One patient had radiotherapy due to recurrence of lesion, nevertheless malignant transformation of chondroblastoma occurred in time. Seven patients manifested local recurrence, and one of them even had relapse on two occasions and malignant transformation of chondroblastoma. Malignant lesions were found in three cases (10% of patients; one lesion was diagnosed as primary while other two malignancies were detected only after recurrence, and the treatment was completed by lower leg amputation.

  2. Chondroblastoma of the hands and feet

    Energy Technology Data Exchange (ETDEWEB)

    Davila, Jesse A.; Amrami, Kimberly K.; Sundaram, Murali; Adkins, Mark C. [Mayo Clinic, Department of Radiology, Rochester (United States); Unni, Krishnan K. [Mayo Clinic, Department of Surgical Pathology, Rochester (United States)

    2004-10-01

    To review the imaging findings, age and gender distribution of chondroblastoma of the hands and feet. Twenty-five cases of pathologically proven chondroblastoma of the hands and feet were reviewed. Available imaging modalities included radiographs (n=24), CT (n=3), MRI (n=5), and radionuclide bone scintigraphy (n=1). The following imaging features for each case were tabulated: location, presence of sclerotic margin, calcification, expansion, presence of fluid/fluid levels on cross-sectional imaging and surrounding edema on MRI. The images were evaluated for skeletal maturity using closure of the physeal plate in the region as a standard. The average age at time of diagnosis was 23 years (range 7-57 years). Eighty-four percent (n=21) of the patients were skeletally mature. Males (20 of 25) outnumbered females by a ratio of 5:1. The bones of the foot accounted for 22 cases: calcaneus (n=8), talus (n=8), metatarsals (n=3), and the cuboid (n=3). The bones of the hand accounted for three cases: phalanx (n=1), triquetrum (n=1), and a metacarpal (n=1). Radiographically all lesions were osteolytic with identifiable calcification in 54% (13 of 24). Fluid/fluid levels were seen in four of five cases on MRI. Edema on MR images was seen in 40% (2 of 5). The size of the lesions ranged from 2 to 41 cm{sup 2}. Chondroblastomas of the hands and feet share many of the radiographic characteristics seen in the long bones, but manifest in skeletally mature patients with a higher male to female ratio than in long bone chondroblastoma. Talar and calcaneal lesions were encountered only in males. Chondroblastoma of the wrist and hand appears to be exceptionally rare. (orig.)

  3. Fine needle aspiration cytology of chondroblastoma of the fibula

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    Kamal Malukani

    2014-01-01

    Full Text Available Chondroblastoma is a rare benign cartilaginous tumor typically seen in long bones, especially femur, tibia and proximal humerus. Extracortical soft tissue invasion or metastasis is rarely seen. We report here a unique case of chondroblastoma of the fibula with extracortical soft tissue invasion. Differential diagnosis on cytology is discussed.

  4. Fine needle aspiration cytology of chondroblastoma of the fibula.

    Science.gov (United States)

    Malukani, Kamal; Nandedkar, Shirish S; Yeshwante, Prashant; Rihal, Preeti

    2014-01-01

    Chondroblastoma is a rare benign cartilaginous tumor typically seen in long bones, especially femur, tibia and proximal humerus. Extracortical soft tissue invasion or metastasis is rarely seen. We report here a unique case of chondroblastoma of the fibula with extracortical soft tissue invasion. Differential diagnosis on cytology is discussed.

  5. Peculiar chondroblastoma involving multiple tarsal bones

    Energy Technology Data Exchange (ETDEWEB)

    Fukunaga, Masaharu [Jikei University School of Medicine, Department of Pathology, Tokyo (Japan); the Jikei University Daisan Hospital, Department of Pathology, Tokyo (Japan); Asanuma, Kazuo [Jikei University School of Medicine, Department of Orthopedic Surgery, Tokyo (Japan); Irie, Takeo [Jikei University School of Medicine, Department of Radiology, Tokyo (Japan)

    2010-07-15

    A case of peculiar chondroblastoma involving multiple tarsal bones in a 49-year-old woman is described. The patient presented with pain and swelling of the right foot. Radiographs revealed a lytic expansile lesion of medial, intermediate, and lateral cuneiform bones, navicular, cuboid, and tarsal bones of the right foot, indicating a malignant tumor. Biopsies demonstrated a diffuse proliferation of round cells with eccentric and indented nuclei with longitudinal grooves and eosinophilic cytoplasm. Atypia was prominent, but mitotic figures were rare. The stroma was chondroid with focal chicken-wire calcification. On electron microscopy, the tumor exhibited chondroblastic features. The patient is alive with the tumor 7 years after radiotherapy. The tumor is considered a chondroblastoma with low malignant potential. (orig.)

  6. CHONDROBLASTOMA IN DISTAL TIBIA - A CASE REPORT

    Directory of Open Access Journals (Sweden)

    Chinmaya

    2013-04-01

    Full Text Available INTRODUCTION: Chondroblastoma was first described as calcified gi ant cell tumour by Ewing. Codman described it as epiphyseal chondromatous giant cell tumour. Jaffe and Lichtenstein named it as chondroblastoma, a rare benign cartilag inous tumour. It represents less than 1% of all primary bone tumours and most commonly originate from the epiphyses of long bones, particularly from the epiphyses of the proximal and dis tal parts of the femur, the proximal part of the humerus, and the proximal part of the tibia. O ther reported sites are talus, scapula , patella, pelvis, distal radius, distal tibia , ribs, proximal fibula, calcaneum. Its occurrence in distal tibia is very rare with 2 documented cases in UK from 1974 to 2000, 3 documented cases in FRANCE from 1950 to 200 5 , no documented case from 1977 to 2000 in Harvard, USA. The purpose is to present a rare tumour occurring at an unusual site.

  7. Calcaneal chondroblastoma with pathologic fracture and recurrence.

    Science.gov (United States)

    Dutt, Laksha; Schade, Valerie L; Manoso, Mark W

    2015-01-01

    Chondroblastomas account for 80% of cases. Local recurrence rates of ≤38% have been reported, most often because of inadequate resection, and have been associated with malignant conversion and metastasis. Adjuvant therapies can help minimize the incidence of local recurrence. Long-term follow-up examinations are recommended, given the protracted interval that can exist between recurrence and the potential for malignant conversion and metastasis. We present the case of a young, healthy, active male with a calcaneal chondroblastoma and associated pathologic fracture whose initial treatment consisted of curettage, hydrogen peroxide lavage, and allogeneic bone grafting. Recurrence developed at 15 months postoperatively and was treated with repeat curettage, high-speed burring, and reconstruction with steel Steinman pins and polymethylmethacrylate, resulting in no pain or recurrence at the 5-month follow-up point.

  8. Minimally invasive technique for curettage of chondroblastoma using endoscopic technique.

    Science.gov (United States)

    Errani, C; Traina, F; Chehrassan, M; Donati, D; Faldini, C

    2014-11-01

    Chondroblastoma is a rare benign bone tumor. The treatment for chondroblastoma usually consists of curettage of the lesion and packing the tumor cavity with bone grafts or bone cement. However, chondroblastomas are known to recur in 10% to 20% of cases after excision, possibly because the incomplete removal of pathological tissue at surgery. We present a case of chondroblastoma in the distal femur treated by endoscopic curettage, which allowed a complete resection of tumor tissue and a minimal damage of the bone. The patient had relief of symptoms, rapid function restoration and no local recurrence. Endoscopic curettage is a promising new treatment for chondroblastoma. In fact, the extra-articular technique enters the tumor cavity via a tunnel drilled through the medullary canal, allowing to visualize possible residual tumor tissue or defects of the articular surface, without violating the joint and without taking away a much bigger cortical window.

  9. Coexisting chondroblastoma and osteochondroma: a case report.

    Directory of Open Access Journals (Sweden)

    Pardiwala D

    2002-04-01

    Full Text Available The coexistence of two different types of benign cartilaginous tumours of bone in the same patient has not been reported in literature. We report a case in which a sixteen-year-old male had a benign chondroblastoma of the proximal left humerus and an osteochondroma of the distal left femur. Both originated at the same time and had a progressive increase in size with growth.

  10. Chondroblastoma: Report of two cases diagnosed by cytology

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    Jayasudha A Vasudevan

    2015-01-01

    Full Text Available Chondroblastoma is an uncommon benign cartilage producing neoplasm with a characteristic epiphyseal location. This report documents the cytological features of two cases of chondroblastomas diagnosed by cytology. One of the two cases had an unusual location in the temporomandibular region and the other was located in the epi-metaphyseal region of the right humerus. Smears characteristically revealed chondroblasts and osteoclast-like giant cells. The cytologic diagnosis of chondroblastoma was confirmed on both cases by histopathology. The radiologic appearance and differential diagnosis in both cases are discussed.

  11. Case report 467: Cystic chondroblastoma left 4th rib

    Energy Technology Data Exchange (ETDEWEB)

    Sundaram, M.; McGuire, M.H.; Naunheim, K.; Schajowicz, F.

    1988-03-01

    A case of chondroblastoma in an 18-year-old female arising from a rib near the costotransverse articulation (presumably from the epiphysis of the articular process) has been described. The destructive pattern noted in the rib, associated with a large soft tissue mass, favored a malignant lesion rather than a benign one. Histologically, this tumor had large cystic and hemorrhagic components, consistent with the diagnosis of a cystic chondroblastoma of a rib. Curiously, this patient, like two others with chondroblastoma in a rib was asymptomatic, and attention to the abnormality was drawn from a routine chest radiography. The patient remains disease-free one and a half-years following surgery.

  12. Chondroblastoma and chondromyxoid fibroma : disentangling the neoplastic chondrogenesis of two rare cartilaginous tumours

    NARCIS (Netherlands)

    Romeo, Salvatore

    2010-01-01

    The scope of this study was to disentangle neoplastic chondrogenesis in two rare cartilaginous tumours: chondroblastoma and chondromyxoid fibroma. It was addressed: 1 The spectrum of phenotypic differentiation in chondroblastoma and chondromyxoid fibroma, 2 The signalling pathways driving chondrobla

  13. Cytological diagnosis of chondroblastoma: diagnostic challenge for the cytopathologist.

    Science.gov (United States)

    Akhtar, Kafil; Qadri, Shagufta; Sen Ray, Prasenjit; Sherwani, Rana K

    2014-05-29

    Chondroblastoma is an uncommon osseous neoplasm that accounts for less than 1% of all bone tumours. It characteristically arises in the epiphysis or epimetaphyseal region of long bones and has been reported to affect people of all ages with slight male predilection. WHO has defined chondroblastoma as 'a benign, cartilage-producing neoplasm usually arising in the epiphyses of skeletally immature patients'. The authors document the cytological features on fine-needle aspiration cytology of a chondroblastoma which appeared as a lytic lesion in the upper end of the right fibula, an uncommon site, in an 18-year-old male patient. X-ray feature combined with fine-needle aspiration cytology favoured the diagnosis of chondroblastoma, which was further confirmed by histopathological examination.

  14. Calcaneal chondroblastoma with secondary aneurysmal bone cyst: a case report.

    Science.gov (United States)

    Guedes, Alex; Barreto, Bruno; Soares Barreto, Lara Grimaldi; Athanazio, Daniel A; Athanazio, Paulo R F

    2010-01-01

    We present a case of destructive chondroblastoma associated with secondary aneurysmal bone cyst involving the left calcaneus. Because of the extensive destruction of the calcaneus, total calcanectomy was the treatment of choice.

  15. Operative treatment of chondroblastoma: a study of 11 cases.

    Science.gov (United States)

    Hapa, Onur; Karakaşlı, Ahmet; Demirkıran, Nihat Demirhan; Akdeniz, Olcay; Havitçioğlu, Hasan

    2016-03-01

    Aim of the study was to review the radiological, clinical results of 11 chondroblastoma cases treated at our institute between 2003-2013. All patients with chondroblastoma included in this study underwent intra-lesional curettage+/-bone grafting. Follow up for healing of chondroblastoma lesions and detection of any local recurrence was assessed on clinical and radiological bases. The functional outcome was assessed by the Musculoskeletal Tumour Society scoring system. The mean follow-up period was 6.1 years. There were three recurrences (two femoral head, one proximal tibia). The mean Musculoskeletal Tumour Society functional score was 21. First line aggressive treatment seems appropriate for chondroblastoma especially when localized at lower extremities.

  16. Case report 449: Chondroblastoma involving C5 and C6

    Energy Technology Data Exchange (ETDEWEB)

    Howe, J.W.; Yochum, T.R.; Sladich, M.A.; Baumgard, S.

    1988-01-01

    A case of chondroblastoma of the cervical spine is presented in a sixteen year old male. Both the axial location and the presence of an associated soft tissue mass make this an unusual case. Treatment is briefly considered. (orig.)

  17. Secondary aneurysmal bone cyst following chondroblastoma of the patella.

    Science.gov (United States)

    Tomoyuki, Kato; Susa, Michiro; Nakayama, Robert; Watanabe, Itsuo; Horiuchi, Keisuke; Toyama, Yoshiaki; Morioka, Hideo

    2013-01-01

    Aneurysmal bone cyst (ABC) is a rare benign cystic lesion of the bone that composes 1-2% of the entire bone tumors. Some are idiopathic, and some occur secondary to other tumors such as giant cell tumor and chondroblastoma. In this article, we report the clinical, radiographic, and histological findings of a secondary ABC following chondroblastoma of the patella with a review of the literature.

  18. Diaphyseal chondroblastoma in a long bone: first report

    Energy Technology Data Exchange (ETDEWEB)

    Azorin, D.; Gonzalez-Mediero, I.; Colmenero, I.; Prada, I. de [Hospital Infantil Universitario Nino Jesus, Service of Anatomic Pathology, Madrid (Spain); Lopez-Barea, F. [Hospital Universitario La Paz, Department of Anatomic Pathology, Madrid (Spain)

    2006-01-01

    Chondroblastoma is a rare benign bone tumor typically located in the epiphysis. We describe the first case of chondroblastoma arising in the diaphysis of a long bone. The patient was a 13-year-old girl who presented with pain over her right thigh. Radiographs showed a lytic lesion in the diaphysis of her right femur. A core biopsy and a subsequent surgical resection were performed. (orig.)

  19. Secondary aneurysmal bone cyst following chondroblastoma of the patella

    Directory of Open Access Journals (Sweden)

    Tomoyuki Kato

    2013-09-01

    Full Text Available Aneurysmal bone cyst (ABC is a rare benign cystic lesion of the bone that composes 1-2% of the entire bone tumors. Some are idiopathic, and some occur secondary to other tumors such as giant cell tumor and chondroblastoma. In this article, we report the clinical, radiographic, and histological findings of a secondary ABC following chondroblastoma of the patella with a review of the literature.

  20. Chondroblastoma of the patella with aneurysmal bone cyst.

    Science.gov (United States)

    Tan, Honglue; Yan, Mengning; Yue, Bing; Zeng, Yiming; Wang, You

    2014-01-01

    Chondroblastoma of the patella is rare. Aneurysmal bone cysts, which develop from a prior lesion such as a chondroblastoma, are seldom seen in the patella. The authors report a case of a 36-year-old man who presented with 2 years of right knee pain without calor, erythema, pain on palpation, or abnormal range of motion. Radiological studies suggested aneurysmal bone cyst. The lesion was excised with curettage and the residual cavity filled with autogenous bone graft. Histopathology revealed chondroblastoma associated with a secondary aneurysmal bone cyst. In the follow-up period, the patient demonstrated normal joint activities with no pain. Normal configuration of the patella and bone union were shown on plain radiographs. The authors present a review of the literature of all cases of patellar chondroblastoma with aneurysmal bone cyst. This case is the 14th report of aneurysmal bone cyst arising in a chondroblastoma of the patella. According to the literature, computed tomography and magnetic resonance imaging are useful in the study of these lesions. The pathologic diagnosis is based on the presence of chondroblastoma and aneurysmal bone cyst. Treatment of this lesion includes patellectomy, curettage alone, and curettage with bone grafting. Despite the risk of recurrence of this lesion in the patella, the authors first recommend curettage followed by filling the cavity with bone graft. To protect the anterior tension of the patella intraoperatively, the bone window should be made at the medial edge of the patella to perform the curettage and bone grafting.

  1. Surgical treatment and outcomes of temporal bone chondroblastoma.

    Science.gov (United States)

    Moon, In Seok; Kim, Jin; Lee, Ho-Ki; Lee, Won-Sang

    2008-12-01

    Chondroblastoma is an uncommon primary benign bone tumor that usually arises in the epiphyses of the long bones. Temporal bone chondroblastoma is a rare primary bone tumor that affects the floor of the middle cranial fossa and temporomandibular joint (TMJ). The biological nature of temporal bone chondroblastoma is occasionally aggressive because of local invasion and is known to have a high recurrence after curettage. Therefore, complete resection is recommended. However, the literature provides little information regarding long-term surgical outcomes and complications after surgical resection. The authors have retrospectively analyzed four cases of temporal bone chondroblastoma that had been completely excised by a single surgeon with an eventual long-term follow-up. A single surgeon operated on four patients, two males and two females, with a mean age of 34 years, at the Department of Otorhinolaryngology, Severance Hospital. In all cases, the tumor involved the middle cranial fossa dura and the mandibular fossa with variable degree of infiltration. All patients have had no tumor recurrence to date (mean follow-up period of 5 years). Complete surgical resection of the temporal bone chondroblastoma is the gold standard for treatment. Precise preoperative image evaluation of tumor extension and proper management of the dura mater and temporomandibular joint (TMJ) are the major important features in complete surgical removal that minimize complications in temporal bone chondroblastoma treatment.

  2. Chondroblastoma of the Clivus: Case Report and Review.

    Science.gov (United States)

    Liu, Jonathan; Ahmadpour, Arjang; Bewley, Arnaud F; Lechpammer, Mirna; Bobinski, Matthew; Shahlaie, Kiarash

    2015-11-01

    Background and Importance Chondroblastoma is a benign primary bone tumor that typically develops in the epiphyses of long bones. Chondroblastoma of the craniofacial skeleton is extremely rare, with most cases occurring in the squamosal portion of the temporal bone. In this report, we describe the first case of chondroblastoma of the clivus presenting with cranial neuropathy that was treated with endoscopic endonasal resection. We review the literature on craniofacial chondroblastomas with particular emphasis on extratemporal lesions. Case Presentation A 27-year-old woman presented with severe headache, left facial dysesthesias, and diplopia. Physical examination revealed hypesthesia in the left maxillary nerve dermatome, and complete left abducens nerve palsy. Imaging demonstrated an expansile intraosseous mass originating in the upper clivus with extension superiorly into the sella turcica and laterally to involve the medial wall of the left cavernous sinus. The tumor was completely resected via an endoscopic endonasal approach, with postoperative improvement in lateral gaze palsy. Histopathology was consistent with chondroblastoma. Conclusion Chondroblastoma is a rare tumor of the craniofacial skeleton that should be included in the differential diagnosis of an osteolytic lesion of the clivus. Complete surgical resection remains the mainstay of treatment.

  3. Chondroblastoma with pulmonary metastasis in a patient presenting with spontaneous bilateral pneumothorax: Report of a case.

    Science.gov (United States)

    Tamura, Masaya; Oda, Makoto; Matsumoto, Isao; Sawada-Kitamura, Seiko; Watanabe, Go

    2011-10-01

    Chondroblastoma is a benign bone tumor with a relatively high incidence in older children and adolescents. Although it is generally regarded as a benign neoplasm, it sometimes grows aggressively or recurs but rarely metastasizes to the lung. We herein present a very rare case of a bilateral pneumothorax due to a pulmonary metastasis from a chondroblastoma. A 21-year-old man developed a bilateral pneumothorax 20 months after an operation for a chondroblastoma of the right ischium. A pertinent literature review revealed similar cases of chondroblastoma with pulmonary metastasis, but revealed no reports of a pneumothorax caused by a metastatic chondroblastoma.

  4. Chondroblastoma associated with aneurysmal cyst of the navicular bone: a case report.

    Science.gov (United States)

    Fang, Zhenhua; Chen, Ming

    2013-02-28

    Chondroblastoma is a rare tumor. It is usually benign; however, it can have an aggressive course before or after operative treatment, even resulting in pulmonary metastases. The foot is a rare location for chondroblastoma, and to our knowledge, chondroblastoma occurring in the navicular bone has not been reported previously in the English literature. We describe a case of navicular chondroblastoma case associated with an aneurysmal bone cyst. Treatment consisted of aggressive curettage, phenolization, and bone allograft. The patient was able to resume normal activities after treatment, and there was no recurrence of the chondroblastoma during a follow-up of 3 years.

  5. Chondroblastoma patella presenting as a pathological fracture

    Directory of Open Access Journals (Sweden)

    Gudi Narayan

    2008-01-01

    Full Text Available A 24-year-old male presented with an inability to walk after a trivial fall. He had pain and mild swelling anterior to the right knee for the past one year. X-ray showed a transverse fracture of patella with a lytic lesion occupying most of the two halves of the patella. Fine needle aspiration cytology (FNAC of the lytic lesion revealed a few osteoclastic giant cells and occasional osteoblasts against a hemorrhagic background. Patellectomy was performed. Histology revealed trabecular bone admixed with proliferating chondroid tissue at places admixed with myxoid and fibrous tissue with focal areas of calcification suggestive of chondroblastoma. Focal areas showed osteoclastic giant cells with areas of hemorrhage. The purpose is to present a rare tumor occurring at an unusual site which presented as pathological fracture.

  6. Temporal bone chondroblastoma totally invisible on MRI.

    Science.gov (United States)

    Hiraumi, Harukazu; Arakawa, Yoshiki; Yamamoto, Norio; Sakamoto, Tatsunori; Ito, Juichi

    2016-08-01

    We report a case of temporal bone chondroblastoma that was totally invisible on MRI. The patient was a 64-year-old man who presented with several months history of vertigo. The CT scan with bone window setting showed destruction of the temporomandibular joint, the floor of the middle cranial fossa, and the superior semicircular canal. Calcific foci were seen within the tumor. On MR imaging, the tumor, situating mainly medial to the temporomandibular joint, showed no signal on both T1- and T2-weighted images. The tumor was not enhanced with gadolinium. In summary, the tumor was totally signal negative or "invisible" on pre- and postcontrast T1- and T2-weighted images. The tumor was resected through transpetrosal - transzygomatic approach.

  7. Chondroblastoma of the patella associated with an aneurysmal bone cyst.

    Science.gov (United States)

    Trebse, R; Rotter, A; Pisot, V

    2001-06-01

    Chondroblastoma is a rare, benign tumor of bone, accounting for about 1% of all bone tumor cases. It tends to affect the epiphyseal ends of long bones, most often in males during the first and second decades of life. It has well-characterized radiographic and histologic features but despite its histologically benign appearance a few cases of metastases have been reported. Local recurrences after curettage and bone grafting occur in 11% to 25% of cases. The features of a patellar chondroblastoma are the same as for other locations. In reviewing the literature we found an unusually high male-to-female ratio. It is interesting that the usual treatment of the patellar chondroblastoma has been patellectomy, whereas curettage and bone grafting has predominated in the other locations. We present a computer tomography and magnetic resonance imaging study of a case of chondroblastoma of the patella associated with an aneurysmal bone cyst. To our knowledge, it is the seventh case reported and the second with computer tomography and magnetic resonance imaging studies. We also review and discuss in detail all the cases of patellar chondroblastoma that we found in the literature.

  8. Chondroblastoma with secondary aneurysmal bone cyst of the capitate.

    Science.gov (United States)

    Sato, Eiichi; Ichikawa, Jiro; Ando, Takashi; Sato, Nobutaka; Kawasaki, Tomonori; Haro, Hirotaka

    2014-05-01

    Chondroblastoma is a benign tumor that typically arises in the epiphysis of a long bone. There have been only 2 reported cases of chondroblastoma involving the capitate. This is the first report of chondroblastoma with secondary aneurysmal bone cyst involving the capitate. A 33-year-old man presented with a 3-year history of pain and swelling of the right wrist. Radiography as well as computed tomography showed a radiolucent area and no matrix calcification within the capitate. Magnetic resonance imaging revealed a homogeneous signal that was low on T1-weighted images and high on T2-weighted images and showed only slight enhancement. On the basis of imaging findings, the authors chose excisional biopsy. The bone tumor in the capitate was explored through a dorsal approach by dividing the extensor tendons. After repeated curettages, bone graft substitute using allograft bone was packed into the capitate. Histologically, the authors diagnosed this tumor as a chondroblastoma with a secondary aneurysmal bone cyst. At the final 2-year follow-up, there was evidence of bone union, full range of motion, and recovery and no evidence of recurrence. Although the recurrence of chondroblastoma is occasionally reported, the principal treatment is intralesional curettage and bone graft. High-speed burring, phenol, bone cement, and cryosurgery have been reported to reduce local recurrence. Complete excision of the carpal bone seems to be overtreatment.

  9. "Primary" aggressive chondroblastoma of the humerus: a case report

    Directory of Open Access Journals (Sweden)

    Alva N Kishore

    2004-03-01

    Full Text Available Abstract Background Chondroblastomas are rare epiphyseal bone tumors. Very few cases with extra-cortical aggressive soft tissue invasion or metastasis are reported. Case presentation We report a 28 year-old adult male who presented with a large swelling over the left shoulder region. Pre-operative imaging revealed a large tumor arising from upper end of humerus with extensive soft tissue involvement necessitating a fore-quarter amputation. Patient received adjuvant radiation. Conclusions This patient is one of the largest chondroblastomas to be reported. Although chondroblastomas are typically benign, rarely they can be locally aggressive or metastatic. Early diagnosis and institution of proper primary therapy would prevent mutilating surgeries and recurrences.

  10. Giant chondroblastoma of the scapula with pulmonary metastases

    Energy Technology Data Exchange (ETDEWEB)

    Ozkoc, Gurkan; Ozalay, Metin [Baskent University, Department of Orthopedics and Traumatology, Adana Medical Center, School of Medicine, Adana (Turkey); Gonlusen, Gulfiliz [Cukurova University, Department of Pathology, School of Medicine, Adana (Turkey); Kayaselcuk, Fazilet [Baskent University, Department of Pathology, Adana Medical Center, School of Medicine, Adana (Turkey); Pourbagher, Aysin [Baskent University, Department of Radiodiagnostics, Adana Medical Center, School of Medicine, Adana (Turkey); Tandogan, Reha N. [Baskent University, Department of Orthopedics and Traumatology, School of Medicine, Ankara (Turkey)

    2006-01-01

    A 53-year-old man presented with a 12-year history of a progressively growing solid mass at his left shoulder. A 39 x 30 x 18-cm and 14.440-kg mass including the scapula was resected. Pathologic features were specific for chondroblastoma. During the 36-month follow-up, he had multiple inoperable metastatic lesions in his lungs. Histology of the transthoracic needle biopsy showed the metastatic nodules had features specific for chondroblastoma; however, the microscopic features additionally had hyperchromasia and increased mitotic activity in some areas. In the English literature, there are a few cases of chondroblastoma located in the scapula. It is exceptional to see this lesion in the sixth decade of life and with pulmonary metastases. (orig.)

  11. Primary aggressive chondroblastoma of the humerus: an unusual imaging presentation.

    Science.gov (United States)

    Nouh, Mohamed Ragab; Abu Shady, Hamdy Mohamed; Abodief, Wael Tharwat; Al-Kandary, Salwa Ramadan

    2013-01-01

    Chondroblastoma is an uncommon primary benign cartilage-producing neoplasm representing only 1% of all primary bone neoplasia, with male preponderance. It has a predilection to present in any bone ossified in the endochondral pattern. Epiphyseal location, small size, geographic margins, and cartilaginous matrix are virtually pathognomonic radiologic features of this tumor. The tumor rarely transgresses the parent bone to invade adjacent structures. We describe a histologically proven case of chondroblastoma, invading the adjacent glenohumeral joint in a 15-year-old female presented with shoulder pain, in which radiological features belied the nature of the tumor.

  12. Chondroblastoma of temporomandibular region: report of 3 cases

    Institute of Scientific and Technical Information of China (English)

    钟来平; 陈关福

    2003-01-01

    @@ Chondroblastoma is a rare benign bone tumor, which accounts for less than 1% of all osteocartiginous tumors.1 It is always located in the epiphysis of long bones and is commonly seen in patients of 15-20 years of age. While it is seldom seen in the pelvis and sternum, it is even less frequent in the temporomandibular region. We reported herein three cases of chondroblastoma in the temporomandibular region from June 1994 to October 1998 at the Deparment of Oral and Maxillofacial Surgery in the Second Affiliated Hospital, College of Medicine, Zhejiang University, China.

  13. Chondroblastoma-like osteosarcoma: a case report and review.

    Science.gov (United States)

    Aycan, Osman Emre; Vanel, Daniel; Righi, Alberto; Arikan, Yavuz; Manfrini, Marco

    2015-06-01

    Chondroblastoma-like osteosarcomas are extremely rare malignancies having varying clinical, radiological and histological features. Their rarity causes challenges in both diagnosis and clinical management. They are often misdiagnosed as benign lesions. Their accurate diagnosis is important because they require adequate treatment. Misdiagnosed lesions or undertreatment may result in recurrences. We report a case of chondroblastoma-like osteosarcoma arising in the left first metatarsal bone with tarsometatarsal joint involvement in a 10-year-old boy for whom surgery with an original technique was planned after a multidisciplinary diagnostic review.

  14. [Diagnosis and treatment of chondroblastoma--our experience].

    Science.gov (United States)

    Slavković, Slobodan; Vukasinović, Zoran; Slavković, Nemanja; Spasovski, Dusko

    2006-01-01

    The paper presented the results of diagnostics and treatment of patients with diagnosis of chondroblastoma, treated at the Institute of Orthopedic Surgery "Banjica", Belgrade. A total of 30 patients were analyzed, involving the period from 1975-2004. All important data were obtained using the complete medical documentation, physical examination, radiographic findings and available additional diagnostic procedures. The proximal part of tibia, the proximal part of humerus and the distal part of femur were the most common sites of tumor, accounting for 63% of cases. Higher incidence of chondroblastoma was found in male patients, especially in the second decade of life. Pathohistological tumor verification was done in all patients. The patients were then treated by different surgical procedures, both on account of primary lesion and recurrence. Curettage and osteoplasty using the auto- and homograft were carried out in 21 patients, wide resection in nine cases, and amputation was performed in three cases. One patient had radiotherapy due to recurrence of lesion, nevertheless malignant transformation of chondroblastoma occurred in time. Seven patients manifested local recurrence, and one of them even had relapse on two occasions and malignant transformation of chondroblastoma. Malignant lesions were found in three cases (10% of patients); one lesion was diagnosed as primary while other two malignancies were detected only after recurrence, and the treatment was completed by lower leg amputation.

  15. Free vascularized fibula graft to treat chondroblastoma of the hip.

    Science.gov (United States)

    Riedel, Barth; Franklin, Corinna; Seal, Alex; Stevanovic, Milan

    2012-02-17

    Chondroblastomas are rare tumors that present in the epiphysis of the long bones. Bone grafting following aggressive surgical curettage has yielded the best results. When present in the femoral head, they pose a higher risk of recurrence due to the difficulty of achieving an adequate resection without destroying the structural integrity of the weight-bearing surface. This article describes a case of surgical treatment of a chondroblastoma of the femoral head with the use of a free vascularized fibula graft. A 26-year-old woman had several months of increasing left hip pain and decreased range of motion. Imaging studies confirmed a large bubbly lesion with sclerotic borders in the left femoral head consistent with chondroblastoma. After performing an aggressive and complete excisional biopsy, a large cavitary defect remained in the femoral head. Reconstruction of the defect and structural support was achieved using a free vascularized fibula. Nine years postoperatively, the patient had full hip motion, no pain, and no radiographic evidence of collapse. A free vascularized fibula graft is an excellent option for the reconstruction of a large femoral head defect after chondroblastoma resection.

  16. A massive chondroblastoma in the proximal humerus simulating malignant bone tumors.

    Science.gov (United States)

    Tonogai, Ichiro; Takahashi, Mitsuhiko; Manabe, Hiroaki; Nishisho, Toshihiko; Iwamoto, Seiji; Takao, Shoichiro; Kagawa, Seiko; Kudo, Eiji; Yasui, Natsuo

    2013-01-01

    Chondroblastoma is a mostly benign bone neoplasm that typically affects the second decade of life and exhibits a lytic lesion in the epiphysis of long bones. We report an extreme case of massive, destructive chondroblastoma of the proximal humerus in a 9-year-old girl. It was difficult to differentiate using imaging information the lesion from malignant bone tumors such as osteosarcoma. Histopathological examination from biopsy proved chondroblastoma. The tumor was resected after preoperative transcatheter embolization. Reconstructive procedure for the proximal humerus was not performed due to the local destruction. The present case demonstrates clinical and radiological differentiations of the massive chondroblastoma from the other lesions and histopathological understandings for this lesion.

  17. Treatment of chondroblastoma of the calcaneus with a secondary aneurysmal bone cyst using endoscopic curettage without bone grafting.

    Science.gov (United States)

    Otsuka, Takanobu; Kobayashi, Masaaki; Yonezawa, Masato; Kamiyama, Fumiaki; Matsushita, Yasusi; Matsui, Nobuo

    2002-04-01

    Chondroblastoma is a relatively rare benign bone tumor. Approximately 7% of chondroblastomas occur in the calcaneus, and 17% of chondroblastoma associated with cystic lesions. We report a case of a chondroblastoma in the calcaneus with a secondary aneurysmal bone cyst treated successfully by endoscopic curettage without bone grafting. New bone formation is facilitated by minimal damage to the bone and soft tissue. The cosmetic results of this procedure are good. Two years later, the patient is asymptomatic with no radiographic evidence of recurrence. Endoscopic curettage without bone grafting is a promising new treatment for chondroblastoma.

  18. Clear cell chondrosarcoma mimicking chondroblastoma in a skeletally immature patient

    Energy Technology Data Exchange (ETDEWEB)

    Cannon, Christopher P. [Department of Orthopaedic Surgery, Madigan Army Medical Center, Ft. Lewis, WA (United States); Nelson, Scott D. [Department of Pathology and Laboratory Medicine, University of California, Los Angeles School of Medicine, CA (United States); Seeger, Leanne L. [Department of Radiological Sciences, University of California, CA (United States); Eckardt, Jeffrey J. [Department of Orthopaedic Surgery, University of California, Los Angeles School of Medicine, CA (United States)

    2002-06-01

    We report the case of a clear cell chondrosarcoma (CCCS) occurring in the femoral head of a 14-year-old skeletally immature boy. Radiographic examination revealed a well-defined, osteolytic lesion in the epiphysis of the femoral head. Given the patient's age and the radiographic appearance of the lesion, chondroblastoma was high on the differential diagnosis. A frozen section was performed at the time of open biopsy was felt to be consistent with either chondroblastoma or CCCS. CCCS in a skeletally immature patient was felt to be unlikely, so curettage and bone grafting was performed. Final pathology review, however, confirmed the diagnosis of CCCS. The patient was taken back to surgery 4 weeks later for a wide resection and hemiarthroplasty. (orig.)

  19. Chondroblastoma-like chondroma of the hand: case report.

    Science.gov (United States)

    Kuprys, Tomas K; Bindra, Randip; Borys, Dariusz; Nystrom, Lukas M

    2014-05-01

    Chondroblastoma-like chondroma is a rare tumor that almost exclusively manifests in the hand and presents with a set of unique diagnostic features. This tumor has been described in only a limited number of publications and is thus commonly omitted in the differential diagnosis of hand tumors. The diagnostic imaging and histological specimens may initially appear consistent with a number of relatively more common hand tumors, thereby delaying the diagnosis. We present the case of a 49-year-old woman with chondroblastoma-like chondroma of the hand treated with marginal excision. The physical examination, imaging, and needle biopsy made an initial case for giant cell tumor of tendon sheath until histological analysis of the excised specimen yielded the correct diagnosis.

  20. [Pelvic chondroblastoma in an adolescent. New treatment approach].

    Science.gov (United States)

    Rico-Martínez, G; Linares-González, L; Delgado-Cedillo, E; Cerrada-Moreno, L; Clara-Altamirano, M; Pichardo-Bahena, R

    2011-01-01

    Surgical management of tumors located in the spine and the pelvis involves greater difficulty. Moreover, these tumors are usually very large and vascularized. Preoperative embolization of the internal iliac artery is a relatively safe procedure that may reduce the risk of bleeding and local recurrence in the case of benign tumors. Chondroblastoma is a tumor that is rarely located in the pelvis; its more frequent location is the triradiate cartilage. We describe a case of a chondroblastoma with a relapsing aneurysmal cystic component in the acetabulum of an adolescent patient. Treatment consisted of embolization of the internal iliac artery, fluid hyperthermia, hydrogen peroxide and bone marrow application. The patient was found to be asymptomatic at the 5-year postoperative follow-up. The technetium (99mTc) sestamibi scan was negative for tumor activity and found no lung metastases.

  1. Fine needle aspiration cytology of chondroblastoma: A report of two cases with brief review of pitfalls.

    Science.gov (United States)

    Krishnappa, Amita; Shobha, S N; Shankar, S Vijay; Aradhya, Sushma

    2016-01-01

    Chondroblastoma is a rare, giant cell-rich, benign neoplasm of bone. Since the past few decades fine needle aspiration cytology (FNAC) has gained momentum in preoperative diagnosis of bone lesions. At cytology, other giant cell-rich tumors and tumorlike lesions such as aneurysmal bone cyst (ABC), giant cell tumor, and chondromyxoid fibroma fall under the differential diagnosis of chondroblastoma. Due to the difference in the treatment protocol and prognosis, preoperative diagnosis is mandatory. We describe the cytomorphology in two cases of chondroblastoma diagnosed at FNAC and confirmed by histopathology. At cytology, the presence of giant cells, chondroid matrix, mononuclear cells with nuclear indentation, and grooving along with glassy, vacuolated cytoplasm are characteristic of chondroblastoma. In addition to this, the presence of chicken wire calcification is a useful clue to the accurate diagnosis of chondroblastoma at FNAC.

  2. Fine needle aspiration cytology of chondroblastoma: A report of two cases with brief review of pitfalls

    Directory of Open Access Journals (Sweden)

    Amita Krishnappa

    2016-01-01

    Full Text Available Chondroblastoma is a rare, giant cell-rich, benign neoplasm of bone. Since the past few decades fine needle aspiration cytology (FNAC has gained momentum in preoperative diagnosis of bone lesions. At cytology, other giant cell-rich tumors and tumorlike lesions such as aneurysmal bone cyst (ABC, giant cell tumor, and chondromyxoid fibroma fall under the differential diagnosis of chondroblastoma. Due to the difference in the treatment protocol and prognosis, preoperative diagnosis is mandatory. We describe the cytomorphology in two cases of chondroblastoma diagnosed at FNAC and confirmed by histopathology. At cytology, the presence of giant cells, chondroid matrix, mononuclear cells with nuclear indentation, and grooving along with glassy, vacuolated cytoplasm are characteristic of chondroblastoma. In addition to this, the presence of chicken wire calcification is a useful clue to the accurate diagnosis of chondroblastoma at FNAC.

  3. [Chondroblastoma in the anterior cruciate ligament origo: a case report].

    Science.gov (United States)

    Aydin, Hafız; Turhan, Ahmet Uğur; Karataş, Metin; Onay, Atilgan; Yildiz, Kadriye

    2012-01-01

    Chondroblastoma is a rarely seen cartilage originated tumor. It is mostly localized in the epiphysis of long bones. In this article, we present an 18-year-old male case in whom the tumor was located in the right distal femoral lateral condyle and destroyed anterior cruciate ligament origo. The tumor was curetted and the cavity was filled with cement. Anterior cruciate ligament resection was mandatory for this treatment. The patient had no complaint in the postoperative period.

  4. Intracortical chondroblastoma mimicking intra-articular osteoid osteoma

    Energy Technology Data Exchange (ETDEWEB)

    Ishida, Tsuyoshi; Mukai, Kiyoshi [First Department of Pathology, Tokyo Medical University, Shinjuku 6-1-1, Shinjuku-ku, Tokyo 160-8402 (Japan); Goto, Takahiro [Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo (Japan); Motoi, Noriko [Department of Pathology, Toranomon Hospital, Tokyo (Japan)

    2002-10-01

    We report a case of intra-articular intracortical chondroblastoma of the femoral condyle which radiologically appeared to be osteoid osteoma. A 19-year-old woman presented with a 3-year history of gradually increasing pain in the right knee and had been on nonsteroidal anti-inflammatory drugs for pain relief. Laboratory data were within normal limits. Radiographs showed a well-demarcated lucent lesion in the medial condyle of the right femur. A nidus-like lesion with calcifications and a sclerotic rim located in the cortex was imaged by computed tomography scan. Magnetic resonance imaging revealed bone marrow edema and soft tissue swelling around the lesion, with low signal intensity of the nidus-like lesion on both T1- and T2-weighted images. The lesion was excised en bloc and the histological diagnosis of chondroblastoma was made. A mild inflammatory reaction was observed in the bone marrow and synovium around the tumor. The chondroblastoma cells were shown to express cyclooxygenase-2 with immunohistochemistry. (orig.)

  5. MR findings of chondroblastoma with emphasis on enhancement pattern

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Kyung Joong; Go, Sung Hye; Lee, Gyung Kyu; Kim, Jung Eun; Choi, Jung A; Park, Chang Min; Choi, Seung Hong; Kang, Heung Sik [Seoul National University College of Medicine, Seoul (Korea, Republic of); Ahn, Jung Mo [Samsung Medical Center, Seoul (Korea, Republic of); Kim, Sung Moon [Asan Medical Center, Seoul (Korea, Republic of)

    2003-03-01

    To analyze the MR findings of chondroblastoma and peritumoral bone marrow, focussing on the enhancement pattern. Enhanced MR images obtained from 23 patients with pathologically proven chondroblastoma were retrospectively reviewed by three radiologists. The enhancement pattern was classified as one of three types: homogeneous, heterogeneous, or peripheral rim, while peritumoral bone marrow enhancement was assigned one of four grades. Correlation between the enhancement pattern and T2 signal intensity of a tumor was analyzed by fisher's exact test. The enhancement pattern was homogeneous in ten cases, heterogeneous in six, and involved the peripheral rim in seven. In 11 cases, peritumoral bone marrow enhancement was observed. Among the ten instances of homogeneous enhancement the signal intensity seen at T2W1 was homogeneously iso or low in six cases, homogeneously high in two, and heterogeneous in two. Among the seven cases in which three was peripheral rim enhancement, the signal intensity observed at T2W1 was homogeneously high in three, fluid-fluid level in three, and homogeneously iso or low in one. At MR imaging, chondroblastoma shows variable signal intensities and enhancement patterns. The peripheral rim enhancement observed at T2W1 correlated with homogeneously high signal intensity or fluid-fluid levels.

  6. Chondroblastoma: A clinical and radiological study of 104 cases

    Energy Technology Data Exchange (ETDEWEB)

    Bloem, J.L.; Mulder, J.D.

    1985-06-01

    The clinical and radiographic findings in 104 patients with chondroblastoma are presented. Pain was an almost constant presenting complaint, often accompanied in the case of para-articular lesions by impaired function of an adjacent joint. The majority (80%) were in long bones with a mean age of presentation of 16 years. The characteristic radiological image of these lesions was an eccentric radiolucency, having a sharply defined sclerotic margin and containing areas of calcification in approximately a third of cases. They were always related to a growth plate. Nearly half were confined to the affected epiphysis or apophysis itself, but most of the remainder had traversed the growth plate to involve also the adjacent metaphysis. The bones around the knee and the proximal ends of the humerus and femur were the sites of predilection. A minority (20%) affected flat bones and short tubular bones of the hand and foot, with a peculiar affinity for the calcaneus and talus. The mean age of presentation of these was 28 years. The radiological pattern was similar, except for a greater tendency to expand the affected bone. Complications included the formation of a secondary aneurysmal bone cyst in 16 cases (10 of them in long bones), one malignant chondroblastoma, and one fibrosarcoma developing after radiation of the original chondroblastoma.

  7. Condroblastoma de escafoides carpiano Chondroblastoma of the carpal scaphoids

    Directory of Open Access Journals (Sweden)

    F.J. Repáraz

    2008-12-01

    Full Text Available El condroblastoma es un tumor benigno de origen cartilaginoso que representa menos del 1% de todos los tumores óseos primarios. Se localiza típicamente en la epífisis de los huesos largos. Un 10% de los condroblastomas afectan a huesos del pie y de la mano. El asiento de esta lesión en el carpo es extraordinariamente raro. Se presenta un caso de condroblastoma del escafoides del carpo que fue tratado mediante curetaje de la lesión y relleno con injerto óseo autólogo de cresta iliaca.A chondroblastoma is a benign tumour of cartilaginous origin which represents less than 1% of all primary osseous tumours. It is typically localised in the epiphysis of the long bones. Some 10% of chondroblastomas affect the bones of the foot and the hand. It is extremely rare for the seat of this lesion to be in the carpal bones. We present a case of chondroblastoma of the carpal scaphoids that was treated through curretage of the lesion and filling with autologous osseous graft from the iliac crest.

  8. Chondroblastoma of the femoral head: management and outcome.

    Science.gov (United States)

    Strong, D P; Grimer, R J; Carter, S R; Tillman, R M; Abudu, A

    2010-03-01

    Chondroblastoma of the femoral head presents particular problems in treatment because the tumour is surrounded by articular cartilage on one side and epiphyseal plate on the other. Ten patients underwent treatment for a chondroblastoma involving the proximal femoral capital epiphysis. The patients were aged between eight and 19 years and in four the epiphysis was not yet fused. Five had curettage via a drill hole created up the femoral neck, of whom two developed local recurrence. Five had a direct approach to the chondroblastoma through the femoral neck, and there were no local recurrences in this group. Both patients with local recurrence were under 14 years of age-one was cured by a direct approach through the neck of the femur and the other by lifting a trap door of articular cartilage. Apart from one patient with a temporary leg length discrepancy, there were no other complications. We conclude that a direct approach is likely to lead to the best outcome for this rare condition.

  9. Chondroblastoma with secondary aneurysmal bone cyst of the hamate: case report.

    Science.gov (United States)

    Rhee, Peter C; Novais, Eduardo N; Shives, Thomas C; Shin, Alexander Y

    2012-03-01

    Chondroblastoma of the carpals is rare, can mimic other benign bone tumors, and presents a diagnostic challenge. There have been few cases of benign tumors involving the hamate, with only one reported case of chondroblastoma, which was treated with complete hamate excision. We present a case of chondroblastoma with secondary aneurysmal bone cyst of the hamate treated with curettage, high-speed burring, phenol, and autogenous iliac crest bone grafting. At the time of the most recent radiographic follow-up, there was full graft incorporation, preserved hamate morphology, and no evidence of recurrence.

  10. Chondroblastoma arising in the triradiate cartilage. Report of two cases with review of the literature

    Energy Technology Data Exchange (ETDEWEB)

    Matsuno, Takeo; Hasegawa, Isao; Masuda, Takeshi

    1987-04-01

    Chondroblastoma is a relatively rare benign bone tumor of cartilage origin. Roentgenologically it presents usually as a region of lytic destruction of bone with a thin sclerotic rim in the epiphysis of long tubular bone. Less than 9% occur in the pelvic bones but show a tendency to arise from the triradiate cartilage. We present two cases of chondroblastoma originating in the triradiate cartilage, each showing extensive lytic bony destruction and an intrapelvic soft tissue mass. A review of the literature suggests that chondroblastoma of the triradiate cartilage shows an aggressive radiological appearance.

  11. Periprosthetic soft tissue recurrence of chondroblastoma after attempted en bloc excision from the proximal humerus

    Energy Technology Data Exchange (ETDEWEB)

    Hammond, G.W.; Tehranzadeh, J.; Hoang, B.H. [University of California, Irvine, Department of Orthopaedic Surgery, Orange (United States); Gu, M. [University of California, Irvine, Department of Pathology, Orange (United States)

    2006-01-01

    A case of soft tissue recurrence of chondroblastoma after attempted en bloc excision and endoprosthetic replacement is described. This tumor in the proximal humerus recurred after initial curettage and was subsequently treated by attempted en bloc excision with positive microscopic margins. The patient then presented with a large soft tissue recurrence surrounding the endoprosthesis. This periprosthetic recurrence necessitated re-excision and revision of the endoprosthesis. Recurrence is not uncommon following curettage of chondroblastoma. However, less is known about soft tissue recurrence after en bloc resection of this tumor with positive margins. A subset of chondroblastoma may exist with more locally aggressive behavior. (orig.)

  12. [Chondroblastoma of the Temporal Bone Removed Using a Middle Cranial Fossa Approach].

    Science.gov (United States)

    Ishioka, Kaoru; Kanzaki, Jin; Harada, Tatsuhiko; Takanashi, Yoshihiro; Shinonaga, Masamichi; Kitamura, Hajime

    2015-03-01

    We report a case of chondroblastoma of the middle cranial fossa, probably arising from the (infra) mandibular fossa, and expanding to the attic and external auditory canal that was successfully removed using a middle cranial fossa approach. No recurrences occurred during an 8-year postoperative follow-up period. Initial biopsy findings suggested a pathological diagnosis of giant cell tumor that was later confirmed to be a chondroblastoma based on an immunohistochemical study of S-100. This case study suggests a profound understanding of the clinical features, histopathological characteristics, and possible treatment. of chondroblastoma.

  13. [Femoral head chondroblastoma and reconstruction with osteochondral allograft. Case report].

    Science.gov (United States)

    Orlando-Díaz, C; Guzmán-Vargas, R; Rincon-Cardozo, D F; Mantilla-León, N; Camacho-Casas, J A

    2014-01-01

    Femoral head chondroblastoma is an infrequent tumor, accounting for approximately 1-2% of benign bone tumors. It occurs more frequently in young male patients. It's most frequent locations include the proximal humerus, proximal femur, distal femur and proximal tibia. The femoral head is the third most frequent site of this tumor. There is no specific treatment for this entity; reported treatments range from acetabular osteotomies and osteochondral grafts, to vascularized fibular grafts, all of them with good results. However, this tumor is clinically unpredictable if left untreated. We report a case managed with osteochondral graft and followed-up for three years after the surgical procedure.

  14. Chondroblastoma: a rare cause of femoral neck fracture in a teenager.

    Science.gov (United States)

    Paloski, Michael D; Griesser, Michael J; Jacobson, Mark E; Scharschmidt, Thomas J

    2011-09-01

    Chondroblastomas usually present in the epiphyseal region of bones in skeletally immature patients. These uncommon, benign tumors are usually treated with curettage and use of a bone-void filler. Here we report a case of a hip fracture secondary to an underlying chondroblastoma in a 19-year-old woman. Open biopsy with intraoperative frozen section pointed toward a diagnosis of chondroblastoma. Extended curettage was performed, followed by cryotherapy with a liquid nitrogen gun and filling of the defect with calcium phosphate bone substitute. The femoral neck fracture was stabilized with a sliding hip screw construct. The patient progressed well and continued to regain functional status. A final pathology report confirmed the lesion to be a chondroblastoma. Clinicians should have heightened awareness of a pathologic lesion in a young person presenting with a femoral neck fracture and should consider the uncommon differential diagnosis that the lesion is located in the greater trochanter apophysis.

  15. A Massive Chondroblastoma in the Proximal Humerus Simulating Malignant Bone Tumors

    Directory of Open Access Journals (Sweden)

    Ichiro Tonogai

    2013-01-01

    Full Text Available Chondroblastoma is a mostly benign bone neoplasm that typically affects the second decade of life and exhibits a lytic lesion in the epiphysis of long bones. We report an extreme case of massive, destructive chondroblastoma of the proximal humerus in a 9-year-old girl. It was difficult to differentiate using imaging information the lesion from malignant bone tumors such as osteosarcoma. Histopathological examination from biopsy proved chondroblastoma. The tumor was resected after preoperative transcatheter embolization. Reconstructive procedure for the proximal humerus was not performed due to the local destruction. The present case demonstrates clinical and radiological differentiations of the massive chondroblastoma from the other lesions and histopathological understandings for this lesion.

  16. Diaphyseal Chondroblastoma in the Tibia:One Case Report and Literatures Review

    Institute of Scientific and Technical Information of China (English)

    Xiaojun Ma; Yang Dong; Chunlin Zhang; Bingfang Zeng; Jian Ding

    2008-01-01

    @@ Chondroblastoma iS a rare benign cartilaginous neoplasm that ac-counts for approximately 1%Of all bone tumors and characteristicallyarises in the epiphysis of a long bone,particularly the humerus,femurand tibiat[1].

  17. Chondroblastoma of the cuboid with an associated aneurysmal bone cyst: a case report

    Directory of Open Access Journals (Sweden)

    Sepah Yasir

    2007-11-01

    Full Text Available Abstract We report the case of a young adult who presented with a painful foot due to chondroblastoma associated with an aneurismal bone cyst. Chondroblastoma is a rare benign cartilaginous neoplasm that accounts for approximately 1% of all bone tumors and characteristically arises in the epiphysis of a long bone, particularly the humerus, tibia, and femur. Chondroblastoma can affect people of all ages. It is, however, most common in children and young adults between the ages of 10 and 20 years. Association of chondroblastoma with aneurysmal bone cyst is well documented however this association has only once been reported in the cuboid. Imaging techniques should be supplemented with an open biopsy for the final diagnosis. Management with curettage, use of high speed burr and bone grafting has shown very good outcomes.

  18. Cortical chondroblastoma: report of a case and literature review of this lesion reported in unusual locations

    Energy Technology Data Exchange (ETDEWEB)

    Hameed, Meera R. [University of Medicine and Dentistry, New Jersey Medical School of Pathology, Newark, NJ (United States); New Jersey Medical School, Department of Pathology and Laboratory Medicine, Newark, NJ (United States); Blacksin, Marcia [University of Medicine and Dentistry, New Jersey Medical School of Radiology, Newark, NJ (United States); Das, Kasturi; Aisner, Seena [University of Medicine and Dentistry, New Jersey Medical School of Pathology, Newark, NJ (United States); Patterson, Francis; Benevenia, Joseph [University of Medicine and Dentistry, New Jersey Medical School of Orthopedic Surgery, Newark, NJ (United States)

    2006-05-15

    Chondroblastoma is a rare benign tumor occurring in adolescence and young adulthood, almost always involving the epiphysis of long bones. A 24-year-old man presented with a discrete soft-tissue lesion penetrating the cortex of the right distal femoral metadiaphyseal region. Biopsy revealed a chondroblastoma, and the patient subsequently underwent a total curettage of the lesion with cancellous bone graft from the iliac crest. (orig.)

  19. [A case of chondroblastoma arising from the temporal bone].

    Science.gov (United States)

    Tsutsumi, Satoshi; Mishima, Yumiko; Nonaka, Yasuomi; Abe, Yusuke; Yasumoto, Yukimasa; Ito, Masanori

    2010-11-01

    A 33-year-old male sustained hearing disturbance in the left ear that exacerbated over a period of three years. The patient was referred to the department of otorhynolaryngology for severe stenosis of the left external auditory canal, where neuroimaging study revealed a huge tumor in the left temporal fossa. On first examination, he showed a significant facial nerve paresis and conductive hearing loss. CT scans identified a 4.5×4.5×4.5 cm mass with intralesional calcification and extensive bony destruction in the squamous and petrous parts of the temporal bone and middle cranial fossa floor. MR imaging demonstrated the tumor of heterogenous intensity on T1-and hypointensity on T2-weighted image. The patient underwent gross total resection of the lesion via frontotemporal craniotomy. The bony and ligamentous structures around the temporomandibular joint appeared mostly intact and did not need any reconstructive surgery after tumor resection. Postoperatively the patient's facial nerve paresis showed a transient exacerbation which resolved gradually, while hearing disturbance did not improve. Histological findings of the tumor were consistent with the qualities of chondroblastoma. We should assume chondroblastoma as differential diagnosis when we encounter a temporal bone tumor that is curable by surgical resection.

  20. Chondroblastoma and clear cell chondrosarcoma: radiological and MRI characteristics with histopathological correlation

    Energy Technology Data Exchange (ETDEWEB)

    Kaim, Achim H.; Huegli, Rolf [Institute of Diagnostic Radiology, University Hospital Basle (Switzerland); Bonel, Harald M. [Institute of Clinical Radiology, University Hospital, Munich-Grosshadern (Germany); Jundt, Gernot [Institute of Pathology, University Hospital Basle (Switzerland)

    2002-02-01

    Objective: To analyze and compare the radiological and magnetic resonance imaging (MRI) appearances of chondroblastoma and clear cell chondrosarcoma with histopathological correlation. Design and patients: Twelve patients with histologically proven chondroblastoma and of another four patients with clear cell chondrosarcoma were investigated by radiographs and MRI (T1-, T2-weighted sequences, intravenous gadolinium application). Additionally, the clinical and radiologic data of seven cases of clear cell chondrosarcoma without available MRI were considered. The localization, calcification of tumor matrix, periosteal reaction, cortical bone and patterns of bone destruction were analyzed according to the Lodwick radiological grading system (LRGS). The signal intensity on T1- and T2-weighted sequences, characteristics of contrast enhancement, associated bone marrow edema, soft tissue reaction and joint involvement were evaluated. Histopathological specimens were available in all cases. Results: The age of patients with chondroblastoma (range 15-59 years, mean 22.3 years) was lower than that of those with clear cell chondrosarcoma (range 19-61 years, mean 36.6 years), and the lesions were smaller in the chondroblastoma group (range 1-4 cm, mean 2.3 cm) than in patients with clear cell chondrosarcoma (range 3-7.5 cm, mean 5.2 cm). The chondroblastomas were more confined to the epiphysis (10/12) than the clear cell chondrosarcomas. All chondroblastomas and clear cell chondrosarcomas except one were classified as grade 1A or 1B according to the LRGS; one clear cell chondrosarcoma was judged as grade 2. Signal intensity of the tumors on MRI was very heterogeneous in both groups. High signal intensity on T2-weighted MR images in chondroblastoma mostly corresponded to areas with aneurysmal bone cyst components and in clear cell chondrosarcoma to islands of hyaline cartilage. Contrast enhancement occurred in all tumors and tended to be more intense with clear cell

  1. Radiofrequency ablation of chondroblastoma using a multi-tined expandable electrode system: initial results

    Energy Technology Data Exchange (ETDEWEB)

    Tins, Bernhard; Cassar-Pullicino, Victor; McCall, Iain [RJAH Orthopaedic and District Hospital, Department of Radiology, Oswestry (United Kingdom); Cool, Paul [RJAH Orthopaedic and District Hospital, Musculoskeletal Tumour Unit, Oswestry (United Kingdom); Williams, David [Hereford Hospital, Department of Orthopaedics, Hereford (United Kingdom); Mangham, David [RJAH Orthopaedic and District Hospital, Department of Pathology, Oswestry (United Kingdom)

    2006-04-15

    The standard treatment for chondroblastoma is surgery, which can be difficult and disabling due to its apo- or epiphyseal location. Radiofrequency (RF) ablation potentially offers a minimally invasive alternative. The often large size of chondroblastomas can make treatment with plain electrode systems difficult or impossible. This article describes the preliminary experience of RF treatment of chondroblastomas with a multi-tined expandable RF electrode system. Four cases of CT guided RF treatment are described. The tumour was successfully treated in all cases. In two cases, complications occurred; infraction of a subarticular chondroblastoma in one case and cartilage and bone damage in the unaffected compartment of a knee joint in the other. Radiofrequency treatment near a joint surface threatens the integrity of cartilage and therefore long-term joint function. In weight-bearing areas, the lack of bone replacement in successfully treated lesions contributes to the risk of mechanical failure. Multi-tined expandable electrode systems allow the treatment of large chondroblastomas. In weight-bearing joints and lesions near to the articular cartilage, there is a risk of cartilage damage and mechanical weakening of the bone. In lesions without these caveats, RF ablation appears promising. The potential risks and benefits need to be evaluated for each case individually. (orig.)

  2. Chondroblastoma of the femoral neck as a cause of hip synovitis.

    Science.gov (United States)

    Kaneko, Hiroshi; Kitoh, Hiroshi; Wasa, Junji; Nishida, Yoshihiro; Ishiguro, Naoki

    2012-03-01

    Chondroblastoma is a rare benign chondroid bone tumor, which typically arises from the epiphysis of a long tubular bone. We present a 13-year-old girl with persistent hip synovitis caused by a chondroblastoma that arose from the femoral neck (metaphysis) and uniquely extended extraosseously into the hip joint. Computed tomography scan clearly demonstrated a tumoral lesion of the left femoral neck and a periosteal reaction along the anterior cortex of the femur, distal to the legion. Magnetic resonance imaging showed reactive synovitis with marked joint effusion of the hip and an extensive edema in the proximal femur and the surrounding soft tissues. Aneurysmal bone cysts formation secondary to chondroblastoma was confirmed by histologic examinations of the excised specimens. Complete relief of pain and an improvement in the range of movement of the hip joint was obtained after surgical resection of the tumor.

  3. Chondroblastoma of the knee treated with resection and osteochondral allograft reconstruction.

    Science.gov (United States)

    Fitzgerald, Judd; Broehm, Cory; Chafey, David; Treme, Gehron

    2014-01-01

    Case. This case report describes the operative management of 16-year-old male with a symptomatic chondroblastoma of the distal femur with breach of the chondral surface. Following appropriate imaging and core needle biopsy, the diagnosis was confirmed histologically. The patient then underwent intralesional curettage and osteochondral allograft reconstruction of the defect. At one-year follow-up the patient was pain-free and has obtained excellent range of motion. There is radiographic evidence of allograft incorporation and no evidence of local recurrence. Conclusion. Osteochondral allograft reconstruction is an effective option following marginal resection and curettage of chondroblastoma involving the chondral surface of the distal femur.

  4. Chondroblastoma in a metatarsal treated with autogenous fibular graft: a case report.

    Science.gov (United States)

    Dhatt, Sarvdeep S; Bhagwat, Kishan R; Kumar, Vishal; Dhillon, Mandeep Singh

    2012-01-01

    Chondroblastoma is a relatively rare tumor that mimics giant cell tumor and displays a predilection for long bones. In the present report, we describe the case of a benign chondroblastoma localized to the second metatarsal in a 20-year-old male who presented with a 2-year history of painless left foot swelling. Treatment of the tumor involved excision of the second metatarsal with use of an autologous structural fibular bone graft to stabilize the metatarsus and second toe. After 27 months of follow-up, the patient was ambulating well in regular shoes, with no clinical or radiographic evidence of tumor recurrence.

  5. Chondroblastoma of the Knee Treated with Resection and Osteochondral Allograft Reconstruction

    Directory of Open Access Journals (Sweden)

    Judd Fitzgerald

    2014-01-01

    Full Text Available Case. This case report describes the operative management of 16-year-old male with a symptomatic chondroblastoma of the distal femur with breach of the chondral surface. Following appropriate imaging and core needle biopsy, the diagnosis was confirmed histologically. The patient then underwent intralesional curettage and osteochondral allograft reconstruction of the defect. At one-year follow-up the patient was pain-free and has obtained excellent range of motion. There is radiographic evidence of allograft incorporation and no evidence of local recurrence. Conclusion. Osteochondral allograft reconstruction is an effective option following marginal resection and curettage of chondroblastoma involving the chondral surface of the distal femur.

  6. A rare case of metaphyseodiaphyseal chondroblastoma of proximal femur presenting with constitutional symptoms in a six-year-old child.

    Science.gov (United States)

    Bali, Kamal; Kumar, Vishal; Rawall, Saurabh; Sudesh, Pebam

    2012-03-01

    Primary metaphyseodiaphyseal chondroblastoma is rare. To our knowledge, very few such cases have been reported in the English literature. Insidious onset of pain is the most common complaint in patients with chondroblastoma. A clinical presentation of constitutional symptoms along with a metaphyseodiaphyseal lesion on radiographs in a young child usually points toward a diagnosis of Ewing's sarcoma or infection. Here, we document a case of metaphyseodiaphyseal chondroblastoma of femur in a 6-year-old child presenting with chief local complaints of an intermediate onset pain and swelling along with systemic complaints of fever and malaise. The patient was operated by excision of the tumor and reconstruction using autogenous-free fibular graft.

  7. Temporal bone chondroblastoma with secondary aneurysmal bone cyst presenting as an intracranial mass with clinical seizure activity.

    Science.gov (United States)

    Stapleton, Christopher J; Walcott, Brian P; Linskey, Katy R; Kahle, Kristopher T; Nahed, Brian V; Asaad, Wael F

    2011-06-01

    Chondroblastomas are rare tumors that characteristically arise from the epiphyseal cartilage of long bones of the immature skeleton. Intracranial involvement is uncommon, though the squamous portion of the temporal bone is preferentially affected due to its cartilaginous origin. Patients with temporal bone chondroblastomas classically present with otologic symptoms, while primary neurological complaints are rare. In this report, we describe a 33 year-old man with a chondroblastoma of the temporal bone and an associated aneurysmal bone cyst constituting a large intracranial mass lesion who presented with new-onset seizure activity. We review issues relevant to the pathology and treatment of these lesions.

  8. Chondroblastoma in the long bone diaphysis: a report of two cases with literature review

    Institute of Scientific and Technical Information of China (English)

    Jilong Yang; Wei Tian; Xiongzeng Zhu; Jian Wang

    2012-01-01

    To investigate the clinical characteristics of chondroblastoma with an emphasis on lesions located in the long bone diaphysis,we reviewed the clinical data of 7 patients with histologically proven chondroblastoma treated in Tianjin Medical University Cancer Hospital and Fudan University Cancer Hospital between January 1995 and May 2009.There were two rare cases of chondroblastoma in the long bone diaphysis.One patient with a lesion in the tibial diaphysis underwent intralesional curettage and bone grafting,and the postoperative bone function was measured as excellent according to the Enneking scoring system.The patient was still alive upon follow-up at 60 months.The other patient with a lesion in the humeral diaphysis underwent resection,and the postoperative bone function was excellent at 48 months,at which there was no evidence of recurrence or metastasis.Thus,except for the distinctive site of the long bone diaphysis,which made diagnosis difficult,the patients' ages,symptoms,X-ray and CT images,treatment,and prognosis were in accordance with typical lesions in the epiphysis and metaphysis.The diagnosis of chondroblastoma in the long bone diaphysis significantly depends on histopathologic characteristics.

  9. Chondroblastoma in the long bone diaphysis: a report of two cases with literature review.

    Science.gov (United States)

    Yang, Jilong; Tian, Wei; Zhu, Xiongzeng; Wang, Jian

    2012-05-01

    To investigate the clinical characteristics of chondroblastoma with an emphasis on lesions located in the long bone diaphysis, we reviewed the clinical data of 7 patients with histologically proven chondroblastoma treated in Tianjin Medical University Cancer Hospital and Fudan University Cancer Hospital between January 1995 and May 2009. There were two rare cases of chondroblastoma in the long bone diaphysis. One patient with a lesion in the tibial diaphysis underwent intralesional curettage and bone grafting, and the postoperative bone function was measured as excellent according to the Enneking scoring system. The patient was still alive upon follow-up at 60 months. The other patient with a lesion in the humeral diaphysis underwent resection, and the postoperative bone function was excellent at 48 months, at which there was no evidence of recurrence or metastasis. Thus, except for the distinctive site of the long bone diaphysis, which made diagnosis difficult, the patients' ages, symptoms, X-ray and CT images, treatment, and prognosis were in accordance with typical lesions in the epiphysis and metaphysis. The diagnosis of chondroblastoma in the long bone diaphysis significantly depends on histopathologic characteristics.

  10. The cryosurgical treatment of chondroblastoma of bone: long-term oncologic and functional results.

    NARCIS (Netherlands)

    Geest, I.C.M. van der; Noort, M.P. van; Schreuder, H.W.B.; Pruszczynski, M.; Rooy, J.W.J. de; Veth, R.P.H.

    2007-01-01

    BACKGROUND: Chondroblastoma of bone is a rare tumor that occurs most often in the epiphysis or apophysis of long bones. This benign tumor sometimes shows aggressive or malignant behaviour, and rarely metastases occur. Since wide resection often leads to growth impairment, intra-lesional curettage fo

  11. Malignant chondroblastoma presenting as a recurrent pelvic tumor with DNA aneuploidy and p53 mutation as supportive evidence of malignancy

    Energy Technology Data Exchange (ETDEWEB)

    Ostrowski, M.L. [Department of Pathology and Laboratory Medicine, Baylor College of Medicine, The Methodist Hospital and Texas Children' s Hospital, Houston, Texas (United States); Department of Pathology and Laboratory Medicine, Houston, TX (United States). Methodist Hospital; Johnson, M.E. [Department of Orthopedic Surgery, Baylor College of Medicine, The Methodist Hospital and Texas Children' s Hospital, Houston, Texas (United States); Truong, L.D.; Hicks, M.J.; Spjut, H.J. [Department of Pathology and Laboratory Medicine, Baylor College of Medicine, The Methodist Hospital and Texas Children' s Hospital, Houston, Texas (United States); Smith, F.E. [Department of Oncology, Baylor College of Medicine, The Methodist Hospital and Texas Children' s Hospital, Houston, Texas (United States)

    1999-11-01

    We report a rare case of malignant chondroblastoma, which presented in a 47-year-old man as a recurrent tumor, 18 years following wide excision of a typical pelvic chondroblastoma. Radiologic studies of the recurrent tumor showed a large, lytic, destructive lesion of the right pelvic bones and femur, with a pathologic fracture of the latter, a large pelvic soft tissue mass, and multiple pulmonary metastases. Biopsy tissue showed typical features of chondroblastoma, but also increased nuclear atypia, hyperchromasia, and pleomorphism, compared to the original tumor, and, most significantly, abnormal mitotic figures. Immunohistochemical studies of the recurrent tumor revealed p53 mutation and extensive proliferative activity, and flow cytometric studies showed DNA aneuploidy, none of which was present in the original tumor. The patient received chemotherapy and radiation, but died of disease eight months after presentation. We also review chondroblastoma in general, to assign this unusual lesion to a tumor subtype. (orig.)

  12. Chondroblastoma of the femoral head disrupting the articular cartilage. Description of a novel surgical technique.

    Science.gov (United States)

    Givissis, Panagiotis; Agathangelidis, Filon; Christodoulou, Evangelos; Christodoulou, Anastasios

    2012-06-01

    Chondroblastoma is a rare benign tumour. Involvement of the femoral head may often lead to a delayed diagnosis. We present the case of a 15-year-old patient with right hip pain which was first attributed to adductor tendinitis. Following aggravation of the symptoms, thorough investigation including a CT-guided biopsy, revealed the diagnosis of chondroblastoma of the femoral head. Removal of the lesion based on the techniques described in literature was not possible, mainly because the articular cartilage was breached. A novel surgical technique was used in order to address the rare location and behaviour of the tumour. This technique offered the patient pain relief and return to his previous every day and sports activities. No recurrence was seen at two years follow-up.

  13. Successful function-preserving therapy for chondroblastoma of the temporal bone involving the temporomandibular joint.

    Science.gov (United States)

    Yokoyama, Junkichi; Yoshimoto, Hitoshi; Ito, Shin; Ohba, Shinichi; Fujimaki, Mitsuhisa; Ikeda, Katsuhisa; Yazawa, Masaki; Fujimiya, Nozomi; Hanaguri, Makoto

    2011-02-14

    We present a case involving a late diagnosis of chondroblastoma of the temporal skull base involving the temporomandibular joint (TMJ). Following an initial misdiagnosis and unsuccessful treatment over a period of 5 years, the patient was referred to our department for further evaluation and possible surgical intervention for occlusal abnormalities, trismus, clicking of the TMJ, and hearing impairment. Based on preoperative immunochemical studies showing positive reaction of multinucleated giant cells for S-100 protein, the final diagnosis was chondroblastoma. The surgical approach - postauricular incision and total parotidectomy, with complete removal of the temporal bone, including the TMJ via the extended middle fossa - was successful in preserving facial nerves and diminishing clinical manifestations. This study highlights a misdiagnosed case in an effort to underline the importance of medical examinations and accurate differential diagnosis in cases involving any tumor mass in the temporal bone.

  14. Successful Function-Preserving Therapy for Chondroblastoma of the Temporal Bone Involving the Temporomandibular Joint

    Directory of Open Access Journals (Sweden)

    Junkichi Yokoyama

    2011-02-01

    Full Text Available We present a case involving a late diagnosis of chondroblastoma of the temporal skull base involving the temporomandibular joint (TMJ. Following an initial misdiagnosis and unsuccessful treatment over a period of 5 years, the patient was referred to our department for further evaluation and possible surgical intervention for occlusal abnormalities, trismus, clicking of the TMJ, and hearing impairment. Based on preoperative immunochemical studies showing positive reaction of multinucleated giant cells for S-100 protein, the final diagnosis was chondroblastoma. The surgical approach – postauricular incision and total parotidectomy, with complete removal of the temporal bone, including the TMJ via the extended middle fossa – was successful in preserving facial nerves and diminishing clinical manifestations. This study highlights a misdiagnosed case in an effort to underline the importance of medical examinations and accurate differential diagnosis in cases involving any tumor mass in the temporal bone.

  15. Condroblastoma benigno do osso occipital: Relato do caso Benign chondroblastoma of the occipital bone: case report

    Directory of Open Access Journals (Sweden)

    João Flávio Mattos Araújo

    1995-12-01

    Full Text Available Condroblastoma benigno é tumor ósseo raro, tendo como origem células cartilagíneas. Classicamente este tumor acomete regiões epifisárias de ossos longos, sendo incomum o envolvimento de ossos do crânio, principalmente o osso occipital. Relatamos o caso de uma paciente com 16 anos de idade, com o diagnóstico de condroblastoma benigno do osso occipital e discutimos os principais aspectos deste tumor.Benign chondroblastoma is a rare bone tumor of immature cartilage cell derivation. This lesion classically occur at the ends of long bones in young persons. Chondroblastoma arising from the occipital bone is extremely rare. We report the case of a 16 year old girl with a benign condroblastoma in the occipital bone, and discuss the clinical, radiological and treatment aspects of this tumor.

  16. Radiofrequency ablation of chondroblastoma: procedure technique, clinical and MR imaging follow up of four cases

    Energy Technology Data Exchange (ETDEWEB)

    Christie-Large, M.; Evans, N.; Davies, A.M.; James, S.L.J. [Royal Orthopaedic Hospital Foundation Trust, Department of Radiology, Birmingham (United Kingdom)

    2008-11-15

    The aim of this study is to describe the procedure technique, clinical and imaging outcomes of patients treated with radiofrequency ablation for chondroblastoma. Four patients (female/male, 3:1; mean age, 13 years; age range; 9-16 years) underwent the procedure. All had pre-operative magnetic resonance imaging (MRI) and symptomatic, biopsy-proven chondroblastomas (two proximal femur, two proximal tibia). The lesion size ranged from 1.5 to 2.5 cm in maximal dimension (mean size, 1.8 cm). Bone access was gained with a Bonopty biopsy needle system (mean number of radiofrequency needle placements, 5; mean ablation time, 31 min). Clinical and MRI follow-up was available in all cases (mean, 12.25 months; range, 5-18 months). All patients reported resolution of symptoms at 2-6 weeks post ablation. At their most recent clinical follow-up, three patients remained completely asymptomatic with full return to normal activities and one patient had minor local discomfort (different pain pattern) that was not limiting activity. All four patients' follow-up MRI studies demonstrated resolution of the oedema pattern around the lesion and temporal evolution of the internal signal characteristics with fatty replacement. Radiofrequency ablation for chondroblastoma provides an alternative to surgical curettage, and we have demonstrated both a clinical improvement in symptoms and the follow-up MRI appearances. (orig.)

  17. RESULTS FROM CLINICAL AND RADIOLOGICAL FOLLOW-UP, AFTER SURGICAL TREATMENT OF CHONDROBLASTOMA

    Science.gov (United States)

    Penna, Valter; Toller, Eduardo Areas; Ferreira, Adriano Jander; Dias, Dante Palloni Costa

    2015-01-01

    Objectives: To evaluate the long-term clinical and radiological results from patients who underwent surgical treatment of chondroblastoma, between 2003 and 2009, by the same surgical team, using the same operative technique. Methods: A retrospective study was conducted on 12 patients with histological diagnoses of chondroblastoma, who were attended between 2003 and 2009 at the Pius XII Foundation (Barretos Cancer Hospital, Barretos, State of São Paulo). These patients underwent surgical treatment with intralesional resection of the tumor, adjuvant electrocauterization and replacement with methyl methacrylate (11 cases) or an autologous graft from the iliac crest (one case). The preoperative evaluation included physical examination, plain radiographs of the site, magnetic resonance imaging, computed axial tomography and bone scintigraphy. The patients were assessed clinically and radiologically according to a predefined protocol, with a series of plain radiographs, and a functional assessment in accordance with the Enneking functional score. Results: The average age at the time of diagnosis was 14 years and 4 months. The most frequent location affected was the distal femoral epiphysis (75%), followed by the proximal tibial epiphysis (16.6%) and the calcaneus (8.4%). There was higher prevalence among the female patients than among the male patients (3:1). In three cases, preoperative biopsy was necessary. During the follow-up, there was no evidence of local tumor recurrence, and all the patients presented an excellent functional result from the surgical technique used, with Enneking scores ranging from 20 to 30. Conclusion: Surgical treatment of chondroblastoma, using intralesional resection, adjuvant electrocauterization and replacement with methyl methacrylate or bone graft produced good results. PMID:27027054

  18. Proximal Tibia Chondroblastoma Treated With Curettage and Bone Graft and Cement Use.

    Science.gov (United States)

    Cho, Hwan Seong; Park, Yeong Kyoon; Oh, Joo Han; Lee, Jung Hyun; Han, Ilkyu; Kim, Han-Soo

    2016-01-01

    Chondroblastoma has a predilection for the epiphyses or apophyses of long tubular bones. Management of lesions in the proximal tibia is challenging because it is difficult to gain access to intraepiphyseal lesions for completion of curettage. From October 2007 to December 2011, 9 patients with de novo chondroblastoma of the proximal tibia underwent surgery at the authors' institution. All patients initially presented with pain, and 5 patients had limitation of range of motion of the ipsilateral knee. Four lesions abutted the tibial attachment sites of the cruciate ligaments. Surgical procedures included intralesional tumor curettage, additional burring, and packing of the defect with bone graft and/or bone cement. The extra-articular approach was used according to tumor location. The medial or lateral parapatellar approach was used when the tumor was located in the anterior two-thirds of the horizontal plane. When a lesion was located in the posterior third, the posteromedial or posterolateral approach was used as the lesion was cornered. Mean duration of follow-up was 47.2 months (range, 27-80 months). No local recurrence or pulmonary metastasis was noted at latest follow-up. Mean functional score was 29.3 points (range, 28-30 points). All patients fully recovered range of motion in the affected knee. No avulsion fracture or anteroposterior instability of the knee joint was detected. Results of the current study suggest that intralesion curettage followed by additional burring with an extra-articular approach is a successful treatment option for chondroblastoma of the proximal tibia.

  19. Chondroblastoma with secondary aneurysmal bone cyst in the anterior skull base

    Directory of Open Access Journals (Sweden)

    Ming Jie Wang, MD, PhD

    2016-06-01

    Full Text Available Chondroblastoma with secondary aneurysmal bone cyst (ABC, especially in the anterior skull base, is an extremely rare condition. A 5-year-old boy presented with a large space-occupying lesion in the anterior skull base along with a left sided-epistaxis, proptosis and decreased vision. Radical excision of the lesion was performed by an endoscopic transnasal and transethmoidal approach. The patient recovered without any recurrence during a follow-up period of up to 28 months. Here, we review this rare case and discuss the clinical presentation and surgical treatment.

  20. False positive {sup 18}F-FDG PET in an ischial chondroblastoma; an analysis of glucose transporter 1 and hexokinase II expression

    Energy Technology Data Exchange (ETDEWEB)

    Hamada, Kenichiro [Osaka University Graduate School of Medicine, Department of Nuclear Medicine and Tracer Kinetics, Osaka (Japan); Osaka University Graduate School of Medicine, Department of Orthopaedics, Osaka (Japan); Ueda, Takafumi; Tamai, Noriyuki; Myoui, Akira; Yoshikawa, Hideki [Osaka University Graduate School of Medicine, Department of Orthopaedics, Osaka (Japan); Tomita, Yasuhiko; Aozasa, Katsuyuki [Osaka University Graduate School of Medicine, Pathology, Osaka (Japan); Higuchi, Ichiro; Hatazawa, Jun [Osaka University Graduate School of Medicine, Department of Nuclear Medicine and Tracer Kinetics, Osaka (Japan); Inoue, Atsuo [Osaka University Graduate School of Medicine, Radiology, Osaka (Japan)

    2006-05-15

    We report a rare case of chondroblastoma arising from the ischium which showed an increased {sup 18}F-FDG uptake. Chondroblastoma is an uncommon lesion and usually involves the epiphysis of long bones. However, in this case, the tumor appeared as a well-defined osteolytic lesion in the ischium on radiographs. MR imaging demonstrated two components in the tumor: a solid one and a multilobular cystic component. {sup 18}F-FDG PET imaging revealed an increased uptake in the ischium. The {sup 18}F-FDG uptake resembled the results observed in malignant bone tumors. A histological diagnosis of chondroblastoma was obtained from tissue of an open biopsy. An immunohistochemical analysis demonstrated weak expression of both Glut-1 and HK-II. These findings suggest that Glut-1 and HK-II expression are not strongly related to FDG uptake in chondroblastoma. (orig.)

  1. Radiofrequency ablation of chondroblastoma: long-term clinical and imaging outcomes

    Energy Technology Data Exchange (ETDEWEB)

    Xie, Cheng; Jeys, Lee [The Royal Orthopaedic Hospital Foundation Trust, Department of Oncology, Birmingham (United Kingdom); James, Steven L.J. [The Royal Orthopaedic Hospital Foundation Trust, Department of Radiology, Birmingham (United Kingdom)

    2015-04-01

    To investigate the long-term clinical and imaging outcomes of patients with chondroblastoma treated by radiofrequency ablation (RFA). Retrospective analysis of 25 consecutive patients treated with RFA from September 2006 to December 2013. Patients were reviewed within one month of the procedure, then every 3-6 months, and yearly for up to three years. Serial magnetic resonance imaging (MRI) was performed at follow-up to monitor recovery. Functional outcome was assessed using the Musculoskeletal Tumour Society Score (MSTS). Pre-procedure MRI confirmed osteolytic lesions (size range 1.0-3.3 cm; mean 2.0 cm). Patients reported continued symptomatic improvement at four months review. Serial MRI confirmed progressive resolution of inflammation with fatty consolidation of cavity. 88 % of patients became asymptomatic during the follow up period. Three patients' (12 %) symptoms returned at 16, 22 and 24 months respectively after RFA. MRI and biopsy confirmed recurrence in these patients. Functional assessment using MSTS score had an average score of 97.5 %. Mean follow up for the study group was 49 months. RFA is an effective alternative to surgery in the management of chondroblastoma. We recommend a multi-disciplinary approach and RFA should be considered as a first-line treatment. Long-term follow-up is required for timely detection of recurrences. (orig.)

  2. 成软骨细胞瘤的MRI表现特点%MRI features of chondroblastoma

    Institute of Scientific and Technical Information of China (English)

    程晓光; 刘霞; 程克斌; 刘薇

    2009-01-01

    Objective To evaluate the MR imaging features of chondrnblastoma. Methods MRI examinations of 20 patients with histological proven chondroblastoma were reviewed retrospectively. The MRI findings of chondroblastoma including the signal intensity, the shape, the growth patterns, and the surrounding bone marrow edema and the adjacent soft tissue edema, the periosteal reaction, the adjacent joint effusion were analyzed . Results All 20 cases demonstrated heterogeneous MR signal intensity on T1WI and T2WI images and showed Iobular margins. Sixteen cases demonstrated expansive growth patterns. Surrounding bone marrow edema was found in 18 cases and adjacent soft tissue edema in 14 cases. Periosteal reaction was identified in 6 cases. In 7 cases the tumor extended to adjacent soft tissue. Adjacent joint effusion was visible on MRI in 6 cases. Conclusion Heterogeneous signal intensity, lobular margins and expansive growth pattern, adjacent bone marrow and soft tissue edema were the common features of chondroblastoma on MRI.%目的 分析成软骨细胞瘤的MRI表现特点.方法 对经病理证实的20例成软骨细胞瘤的MRI信号特点、病灶形态和生长方式,以及周围骨髓和软组织有无水肿、有无骨膜反应、相邻关节有无积液等征象进行分析.结果 20例病灶在T1WI和T2WI上表现为不均质的混杂信号,病灶形态为分叶状;16例病灶呈膨胀性生长;18例病灶周围出现骨髓水肿;14例病灶周围软组织水肿;6例病灶周围有骨膜反廊;7例病灶突破骨皮质向周围突出;6例棚邻的关节有关节积液.结论 成软骨细胞瘤在MRI上多表现为分叶状和膨胀性生长,病变呈不均质混杂信号,病灶周围有明显的骨髓水肿和邻近软组织水肿.

  3. Chondroblastoma of squamous part of the temporo-parietal region of skull vault: A case report and review of literature

    Directory of Open Access Journals (Sweden)

    S Sateesh Chavan

    2012-01-01

    Full Text Available Chondroblastoma of squamous part of temporal bone is a very rare bone tumor. Although most of them are benign, the prognosis is not predictable. A 14-year-old girl presented with recurrent slowly growing mass over the right side of the temporo-parietal region of skull vault. Initial curettage material showed extensive chondroid areas and diagnosed histologically as "enchondroma." Histology of completely excised recurrent mass showed identifiable chondroblastic foci. She was followed up for 3 years and was free from recurrence. Chondroblastomas at very rare sites such as squamous part of temporal bone have variable histology, confusing with other giant cell lesions, variable prognosis, and require prompt diagnosis and complete excision.

  4. Arthroscopic burring of exposed cement following curettage and cavity filling cementation for chondroblastoma of the proximal tibia.

    Science.gov (United States)

    Park, Jong-Hoon; Chae, In-Jung; Han, Seung-Beom; Lee, Dae-Hee

    2015-03-01

    Chondroblastoma of the proximal tibia is difficult to treat because of its epiphyseal predilection. This condition can be treated by curettage, which results in immediate restoration of stability and a reduced recurrence rate, followed by cement filling of the bone defect. Nevertheless, contact with cement can damage articular cartilage, potentially leading to severe knee osteoarthritis. Most previous reports regarding this complication described patients with giant cell tumors of the proximal tibia. We present here a patient who underwent arthroscopic treatment for cement exposure caused by articular cartilage loss of the tibial plateau, which occurred after initial curettage and cementation for chondroblastoma of the proximal tibia. To our knowledge, this is the first report on arthroscopic treatment of this condition.

  5. Benign chondroblastoma on fine-needle aspiration smears: A seven-case experience and review of the literature.

    Science.gov (United States)

    Cozzolino, Immacolata; Zeppa, Pio; Zabatta, Assunta; Merolla, Francesco; Vetrani, Antonio; Sadile, Francesco

    2015-09-01

    We report seven cases of chondroblastoma (CB) of bone, diagnosed by Fine-Needle Aspiration Cytology (FNAC), and confirmed by histomorphological examination. The concurrence of some cytomorphologic findings - mononucleated cells, multinucleated cells, and intercellular chondroid substance - unequivocally suggested the cytological diagnosis of CB. We also reviewed the literature on this topic in order to discuss morphological criteria and the importance of needle size. The differential diagnosis between CB, Giant Cell Tumor of Bone, and Eosinophilic Granuloma is further discussed.

  6. Non-epiphyseal chondroblastoma arising in the iliac bone, and complicated by an aneurysmal bone cyst: a case report and review of the literature

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jin; Kumar, Rajendra [The University of Texas MD Anderson Cancer Center, Department of Diagnostic Radiology, Houston, TX (United States); Raymond, A.K. [Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX (United States); Ayala, Alberto G. [The Methodist Hospital, Department of Pathology, Houston, TX (United States)

    2010-06-15

    Chondroblastoma is a benign bone tumor that typically arises in the epiphysis of a long bone. However, when it occurs in non-epiphyseal location in flat bones, it may create a diagnostic problem. We describe such a case of chondroblastoma arising in the iliac bone. A 29-year-old man was incidentally found to have a bony pelvic lesion while undergoing evaluation for Crohn's disease. The radiographs and CT revealed an expansile lytic lesion in the right iliac bone. A core biopsy of the lesion was performed. The histopathology revealed the lesion to be a chondroblastoma with secondary features of aneurysmal bone cyst. An en bloc surgical resection of the tumor was performed. (orig.)

  7. A chondroblastoma versus a giant cell tumor: emphasis on the MR imaging features

    Energy Technology Data Exchange (ETDEWEB)

    Chai, Jee Won; Hong, Sung Hwan; Choi, Ja Young; Kim, Na Ra; Choi, Jung Ah; Kang, Heung Sik [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    2007-10-15

    To assess the MR imaging features in differentiating a chondroblastoma (CB) from a giant cell tumor (GCT), with an emphasis on the accompanying peritumoral bone marrow edema. MR imaging findings in 20 patients with CB were compared with the imaging features of 22 patients with GCT. The location of the lesion, signal intensity, adjacent cortical change, degree of accompanying bone marrow edema, synovitis in the adjacent joint and cystic change were analyzed. The findings of CB and GCT were examined statistically with use of Fisher's exact test. The incidence ratios of MR imaging findings were as follows (CB:GCT). Metaphyseal dominant involvement (2:21), partial cortical disruption (2:14), extensive bone marrow edema surrounding the tumor (14:0) and synovitis in the adjacent joint (11:2) were statistically different in incidence between CB and GCT ({rho} < 0.01). The inhomogeneous signal intensity (17:17) and cystic change (10:15) were not different in incidence between a CB and GCT. The presence of metaphyseal dominant involvement and cortical disruption favors a diagnosis of a GCT rather than a CB. In contrast, extensive bone marrow edema surrounding the tumor and synovitis in the adjacent joint are highly indicative of a CB.

  8. Imaging findings of tarsal chondroblastoma%跗骨成软骨细胞瘤的影像表现

    Institute of Scientific and Technical Information of China (English)

    张泽坤; 吴文娟; 李玉清; 张伟; 高静; 孙锋; 王冬梅; 丁建平; 王泽静

    2010-01-01

    目的 探讨跗骨成软骨细胞瘤的影像表现.方法 回顾分析经病理证实的134例成软骨细胞瘤的部位分布情况,对其中11例跗骨成软骨细胞瘤的X线和5例CT表现进行分析.结果 11例跗骨成软骨细胞瘤患者中,病变位于距骨6例、跟骨3例、足舟骨2例.距骨体后部及跟骨后结节为好发部位,X线表现以膨胀性骨质破坏为主(10/11),局部边缘轻度硬化(11/11),骨嵴常见(9/11),关节面破坏常见(7/11),可见斑点状钙化(6/11);CT对关节面破坏(5/5)、小的骨嵴(5/5)以及细小钙化(2/5)的显示更明显.结论 距骨、跟骨是跗骨成软骨细胞瘤好发部位,影像表现具有一定特点,但应结合其发病部位与其他疾病鉴别.%Objective To analysis the imaging features of the chondroblastoma in the tarsal bone. Methods The locations of 134 cases of pathologically confirmed chondroblastoma were retrospectively analyzed. Eleven of them were in tarsal bones and their X-ray and CT findings were analyzed. Results Of the 11 cases of tarsal chondroblastoma, 6 were in talus, 3 were in calcaneus and 2 cases were in navicular bones. They were examined by the X-ray and 5 cases had additional CT scans. The common locations were the posterior portion of the talus and calcaneus. The X-ray findings included expansive destruction (10/11), mild osteosclerosis (11/11), bone ridge (9/11), articular facet destruction (7/11) and spot or patching calcification(6/11). The imaging findings of CT included articular facets destruction (5/5), bone ridge (5/5) and spot or patching calcification (2/5). Conclusion The talus and the calcaneus are the frequently involved location of tarsal chondroblastoma. Its X-ray and CT findings are characteristic but not exclusive.

  9. Chondroblastoma in foot: a clinicopathologic analysis of five cases%足部软骨母细胞瘤5例临床病理分析

    Institute of Scientific and Technical Information of China (English)

    黄利华; 赵晓玲; 桂华伟; 刘国素; 刘冬玲

    2011-01-01

    Purpose To investigate the clinicopathological and immunohistochemical features and imaging changes as well as the prog nosis of chondroblastoma in the foot. Methods The literatures related to chondroblastoma in the foot in recent years were reviewed and five cases were reported. Meanwhile , the diagnosis and differential diagnosis, clinicopathological and immunohistochemical features as well as image changes were analyzed. Results Radiologic features showed an osteolytic lesion. Histologic feature of chondroblastoma included sheets of closely packed roundish or polygonal chondroblastic cells with interspersed multinucleated giant cells and islands of hypocellular eosinophilic cartilage matrix, focal areas of dystrophic calcification, and S-100 ( + ). Conclusion The chondroblastoma occurred in the foot is rare and its estimated incidence is about 13% in chondrohlastoma. The tumor is rare and its diagnosis must be combined the clinical, pathologic features with its image changes.%目的 探讨足部软骨母细胞瘤(chondroblastoma,CB)的临床特点、病理形态、免疫表型、影像学及预后.方法 结合5例足部CB的特点,并复习国内外有关文献报道,分析足部CB的临床、病理和影像的诊断与鉴别诊断及预后.结果 影像学可见溶骨性病变,镜下肿瘤由圆形或多角形软骨母细胞、多核巨细胞、局灶类软骨组织及小的钙化灶等成分组成,瘤组织S-100(+).结论 足部CB较为少见,发生率约占CB的13%,其发生率低,易误诊,应结合临床、病理学、影像学检查进行诊断.

  10. Dual-time-point FDG-PET/CT Imaging of Temporal Bone Chondroblastoma: A Report of Two Cases.

    Science.gov (United States)

    Toriihara, Akira; Tsunoda, Atsunobu; Takemoto, Akira; Kubota, Kazunori; Machida, Youichi; Tateishi, Ukihide

    2015-01-01

    Temporal bone chondroblastoma is an extremely rare benign bone tumor. We encountered two cases showing similar imaging findings on computed tomography (CT), magnetic resonance imaging (MRI), and dual-time-point (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET)/CT. In both cases, CT images revealed temporal bone defects and sclerotic changes around the tumor. Most parts of the tumor showed low signal intensity on T2-weighted MRI images and non-uniform enhancement on gadolinium contrast-enhanced T1-weighted images. No increase in signal intensity was noted in diffusion-weighted images. Dual-time-point PET/CT showed markedly elevated (18)F-FDG uptake, which increased from the early to delayed phase. Nevertheless, immunohistochemical analysis of the resected tumor tissue revealed weak expression of glucose transporter-1 and hexokinase II in both tumors. Temporal bone tumors, showing markedly elevated (18)F-FDG uptake, which increases from the early to delayed phase on PET/CT images, may be diagnosed as malignant bone tumors. Therefore, the differential diagnosis should include chondroblastoma in combination with its characteristic findings on CT and MRI.

  11. An aggressive chondroblastoma of the knee treated with resection arthrodesis and limb lengthening using the Ilizarov technique.

    Science.gov (United States)

    Tomić, Slavko; Lesić, Aleksandar; Bumbasirević, Marko; Sopta, Jelena; Rakocević, Zoran; Atkinson, Henry D

    2010-07-28

    This case report describes the management of a 15 year old male with a biologically aggressive chondroblastoma of the knee. Following CT, bone scan, angiography and an open biopsy, the diagnosis was confirmed histologically and immunohistochemically. The patient underwent a 13 cm en-bloc excision of the knee, and knee arthrodesis with simultaneous bone transport using an Ilizarov ring fixator. Following 136 days of bone transport, the patient achieved radiological and clinical bony union after a total frame time of 372 days. He then commenced 50% partial weight-bear in a protective knee brace and gradually worked up to full weight-bearing by 4 months. The patient developed superficial pin tract infections around the k-wires on 2 occasions; these settled with a cephalosporin antibiotic spray and local dressings. At 13 years follow-up there are no signs of disease recurrence or failure at the fusion site. The patient is able to fully weight bear and stand independently on the operated leg. Knee arthrodesis with simultaneous limb-lengthening is an effective treatment modality following en-bloc resection of an aggressive chondroblastoma. The case is discussed with reference to the literature.

  12. An aggressive chondroblastoma of the knee treated with resection arthrodesis and limb lengthening using the Ilizarov technique

    Directory of Open Access Journals (Sweden)

    Rakočević Zoran

    2010-07-01

    Full Text Available Abstract This case report describes the management of a 15 year old male with a biologically aggressive chondroblastoma of the knee. Following CT, bone scan, angiography and an open biopsy, the diagnosis was confirmed histologically and immunohistochemically. The patient underwent a 13 cm en-bloc excision of the knee, and knee arthrodesis with simultaneous bone transport using an Ilizarov ring fixator. Following 136 days of bone transport, the patient achieved radiological and clinical bony union after a total frame time of 372 days. He then commenced 50% partial weight-bear in a protective knee brace and gradually worked up to full weight-bearing by 4 months. The patient developed superficial pin tract infections around the k-wires on 2 occasions; these settled with a cephalosporin antibiotic spray and local dressings. At 13 years follow-up there are no signs of disease recurrence or failure at the fusion site. The patient is able to fully weight bear and stand independently on the operated leg. Knee arthrodesis with simultaneous limb-lengthening is an effective treatment modality following en-bloc resection of an aggressive chondroblastoma. The case is discussed with reference to the literature.

  13. Dual-time-point FDG-PET/CT Imaging of Temporal Bone Chondroblastoma: A Report of Two Cases

    Directory of Open Access Journals (Sweden)

    Akira Toriihara

    2015-07-01

    Full Text Available Temporal bone chondroblastoma is an extremely rare benign bone tumor. We encountered two cases showing similar imaging findings on computed tomography (CT, magnetic resonance imaging (MRI, and dual-time-point 18F-fluorodeoxyglucose (18F-FDG positron emission tomography (PET/CT. In both cases, CT images revealed temporal bone defects and sclerotic changes around the tumor. Most parts of the tumor showed low signal intensity on T2- weighted MRI images and non-uniform enhancement on gadolinium contrast-enhanced T1-weighted images. No increase in signal intensity was noted in diffusion-weighted images. Dual-time-point PET/CT showed markedly elevated 18F-FDG uptake, which increased from the early to delayed phase. Nevertheless, immunohistochemical analysis of the resected tumor tissue revealed weak expression of glucose transporter-1 and hexokinase II in both tumors. Temporal bone tumors, showing markedly elevated 18F-FDG uptake, which increases from the early to delayed phase on PET/CT images, may be diagnosed as malignant bone tumors. Therefore, the differential diagnosis should include chondroblastoma in combination with its characteristic findings on CT and MRI.

  14. Imaging and therapy of a chondroblastoma; Bildgebung und Therapie eines Chondroblastoms

    Energy Technology Data Exchange (ETDEWEB)

    Nickel, J.; Meyer, D.R.; Geufke, P.; Andresen, R. [Krankenhaus Guestrow, Akademisches Lehrkrankenhaus der Universitaet Rostock (Germany)

    2002-07-01

    The chondroblastoma is a rare lytic osseous lesion, which is typically to be found in the epiphyses of the long tubular bones. We present a case report with the differential diagnostic imaging and the surgical therapy of a chondroblastoma of the proximal tibial epiphysis. A 16-year-old male presented in the traumatological accident and emergency centre with knee pain of unclear origin that had been increasing for several months. He had no memory of any acute trauma. For further clarification, a conventional radiography in two planes, a thin-layer CT, a multiplanar MRI before and after Gd-DTPA, and a bone scan were performed. The conventional radiological diagnostics show a smoothly circumscribed, osteolytic, eccentric lesion with marginal sclerosis, which does not exceed the epiphyseal seam of the proximal tibia. The thin-layer CT reveals an eccentric osteolysis, with a typical, narrow sclerotic seam and central calcifications. In the high-resolution MRI, the T2-weighted sequences show a locally limited, epiphyseal, lubulated lesion with a heterogeneous, in part raised signal. A further signal increase can be seen in the T1-weighted sequences after administration of Gd-DTPA. Perifocally, there is an epiphyseal edema and discrete (intraarticular fluid collection) fluid in the inner knee. In the skeletal scintigraphy, there is a strong focal and diffuse increased activity from the proximal, lateral tibial epiphysis. After the diagnosis had been rendered, curettage of the defect was performed and then, after histological confirmation of the diagnosis, completing spongiosaplasty was conducted. Taking into account the localisation and the patient's age, a virtually certain diagnosis can already be rendered using conventional imaging. A supplementary MRI or CT can be helpful for final clarification, while 3-phase skeletal scintigraphy is superfluous. The therapy of choice is curettage and subsequent filling of the defect with autologous spongiosa. (orig.) [German

  15. 少见部位软骨母细胞瘤的影像学表现%Radiologic feactures of chondroblastoma in unusual sites

    Institute of Scientific and Technical Information of China (English)

    王岩; 陈国栋; 于爱红; 程晓光

    2012-01-01

    Objective:To investigate radiological features of chondroblastoma in unusual sites. Methods:We retrospectively re viewed the radiological features of 20 cases with pathologically proved chondroblastoma in unusual sites. The location,shape,density and enhancement characteristics of the lesions were assessed. Results:The bones involved were the talus (n=6) ,the calcaneus (n= 5) ,the patella (n=4) ,the scapula (n=2) ,the ilium (n = 2) and the ischium (n=l). The characteristic imaging features include round to oval,irregular osteolytic expansive bone destruction with or without septum and slight sclerotic margin on CT and plain ra diography. Spotty or patchy calcification might occasionally be encountered. Typically, chondroblastoma in unusual sites appeared heterogeneously hypointense on T1WI and heterogeneously hyperintense on T2 WI. Conclusion: Chondroblastoma in unusual sites is rare and has varied appearances. Some specific imaging features of the chondroblastoma in unusual sites still exist. Imaging combined with clinical and pathological manifestations is helpful for most accurate diagnosis of the chondroblastoma in unusual sites.%目的:探讨少见部位软骨母细胞瘤(CB)的影像学表现.方法:回顾性分析经病理证实的20例少见部位CB的影像学资料,分析其病灶位置、形态、密度及增强表现等特征.结果:20例中病灶位于距骨6例,跟骨5例,髌骨4例,肩胛骨2例,髂骨2例,坐骨1例.病灶在X线和CT上主要表现为类圆形或不规则形,以膨胀性溶骨性骨破坏为主,周围可见硬化边,其内有或无分隔,边缘可见骨嵴,病灶内偶尔可见点状及片状钙化,痛灶在MRI上表现为不均匀的长T1、长T2信号.结论:少见部位软骨母细胞瘤发病率低,影像学表现具有相对特征性和多样性,应结合临床、影像学和病理学特征进行综合诊断,避免误诊.

  16. Chondroblastoma-like chondroma of soft tissue: report of the first case in the base of skull.

    Science.gov (United States)

    Raparia, Kirtee; Lin, Jerry W; Donovan, Donald; Vrabec, Jeffrey T; Zhai, Qihui Jim; Ayala, Alberto A; Ro, Jae Y

    2013-06-01

    Chondroblastoma-like chondroma (CLC) of soft tissue is a rare benign neoplasm that usually involves the soft tissues of the hand. This report describes the first case of CLC of soft tissue arising in the base of the skull. A 33-year-old man was seen with a slow growing mass in the right parotid region of his face. The noncontrast computed tomographic scans showed an 8.5-cm mass with calcifications involving the right masticator space and extending through the bone into the middle cranial fossa. The radiologic differential diagnosis included osteosarcoma, leiomyosarcoma, chondrosarcoma, and giant cell tumor. During surgery, the large lateral skull base tumor appeared to involve the middle and infratemporal fossae and eroded the surrounding bone. Although the tumor was removed piecemeal, total excision was performed. On microscopic examination, the tumor displayed lobules of mature hyaline cartilage with numerous chondroblasts, coarse calcifications including chicken wire calcifications, and scattered osteoclasts. No atypia, mitoses, necrosis, or osteoid formation was seen. The tumor was diagnosed as chondroma with chondroblastoma features of the soft tissue. His postoperative clinical course was uneventful; however, after 7 months, he had a local recurrence identified on follow-up magnetic resonance imaging. He underwent repeat surgical excision of the tumor, which showed similar histology as the previous excision. This large skull based tumor eroding the bone, which clinically and radiologically mimicked a malignant process, was an unusual presentation of a benign cartilaginous neoplasm. Pathologists should be aware that CLC may occur in the base of the skull and this lesion should be differentiated from the other benign or malignant tumors arising in this area. These lesions have a potential for local recurrence; hence, a close follow-up is recommended.

  17. A case of chondroblastoma combined with bone cysts in the patella%髌骨软骨母细胞瘤合并骨囊肿一例

    Institute of Scientific and Technical Information of China (English)

    王武炼; 陈嵘; 肖莉莉; 陈辉; 刘献祥; 张怡元

    2012-01-01

    The patella is the largest sesamoid bone in the human body, while the tumor incidence is very low in the patella. It is difficult to diagnose patellar tumors because of the complex and changeable imaging findings, and the treatment was often delayed due to misdiagnosis. This paper reported a case of chondroblastoma combined with bone cysts in the patella, and analyzed the diagnosis of several common patellar tumors.

  18. 髌骨软骨母细胞瘤临床病理观察%Clinicopathologic features of chondroblastoma in patella

    Institute of Scientific and Technical Information of China (English)

    杨艳丽; 刘斌; 邢传平; 哈英娣; 苏勤军; 高自芳

    2009-01-01

    Objective To investigate the clinicopathological and immunohistochemical features and imaging changes as well as its prognosis of chondroblastoma in the patella. Methods The literatures related to chondroblastoma in patella during recent three decades were reviewed and a case was reported. Meanwhile, the diagnosis and differential diagnosis, clinicopathological and immunohistochemical features as well as image changes were analyzed. Results This case is a 21-year-old man with left knee pain associated with acratia of left lower extremity in half a year. Radiologic features showed the lesion was lytic in the inner of the patella. Histologic feature of chondroblastoma included sheets of closely packed roundish or polygonal chondroblastic cells with interspersed multinucleated giant cells and islands of hypocellular eosinophilic cartilage matrix, focal areas of dystrophic calcification, S-100 ( + ). Conclusion The chondroblastoma occurred in the ptella is rare and its estimated incidence is about 2% in chondroblastoma. The tumor shows pleomorphic and its diagnosis must incorporate the clinical, pathologic features as well as its image changes.%目的 探讨髌骨软骨母细胞瘤(CB)的临床特点、病理形态、免疫表型、影像学及预后.方法 报告1例髌骨软骨母细胞瘤,复习近38年国内外有关文献报道,分析髌CB瘤的临床、病理和影像的诊断与鉴别诊断及预后资料.结果 患者男性,21岁.左膝部疼痛伴左下肢无力半年.X线片可见髌骨内溶骨性破坏.镜下肿瘤由圆形或多角形软骨母细胞、多核巨细胞、局灶样类软骨组织及小的钙化灶等成分组成,瘤组织S-100(+).结论 软骨母细胞瘤发生在髌骨甚为罕见,其发生率约占软骨母细胞瘤的2%,因其在组织学上表现的多样性应临床、病理学、影像学检查三结合进行诊断.

  19. 成软骨细胞瘤的诊治分析%Diagnosis and treatment of chondroblastoma

    Institute of Scientific and Technical Information of China (English)

    刘如月; 郝玉梅; 吴智辉; 南运东

    2010-01-01

    Objective To summarize the keypoints of clinical diagnosis of chondroblastoma and the experience on the treatment Methods The clinical materials of 16 cases(11 males,aged from 12 to 26 years)from June 1992 to February 2003 of pathologically diagnosed chondroblastoma were analyzed retrospectively. The tumor located at distal femur in 6 cases,great trochanter in 1 case,proximal tibia in 6 cases,proximal humerus in 2 cases, talus in 1 case. The main symptoms were swelling and painful joint. All the 16 cases were treated with curettage and autologous bone graft from iliac crest. Results Twelve cases were followed up for 6 months to 5 years .averaging 3. S years. All the bone graft healed well. One case., recurred 2 years after the initial curettage and was treated with curettage again. No recurrence occurred at the last follow-up 6 months after the second curettage. The function of the involved joints was nearly normal in all cases except for one case with slight limitation of knee flexion. Conclusions Mastering the image and clinical characteristics of chondroblastoma can avoid misdiagnosis and mistreatment Curettage can control the tumor satisfactorily. Postoperative rehabilitation can improve the function of the involved limb.%目的 总结成软骨细胞瘤的临床诊断要点和治疗经验.方法 回顾性分析1992年6月至2003年2月经病理证实的成软骨细胞瘤16例患者的临床资料.肿瘤部位:股骨下端6例,股骨大粗隆1例,胫骨上端6例,肱骨上端2例,距骨1例.主要症状为关节肿胀、疼痛.16例均经手术治疗.手术方式为彻底刮除病灶+自体髂骨植骨.结果 12例患者获得随访,随访时间6个月至5年(平均3.5年),植骨全部融合.1例术后2年复发,行再次刮除植骨,随访6个月未再复发.关节功能除1例股骨远端患者膝关节屈曲稍受限外余全部正常.结论 掌握成软骨细胞瘤的临床特点及影像学特征,有助于减少误诊,正确治疗.手术彻底刮除可达

  20. Secondary aneurysmal bone cystic change of the chondroblastoma, mistaken for a primary aneurysmal bone cyst in the patella.

    Science.gov (United States)

    Chung, Jin Wha; Lee, Hwa Sung

    2014-03-01

    A 29-year-old woman complained of a 3-month history of left knee pain without trauma history. X-ray showed a well-defined osteolytic lesion with a sclerotic margin in the patella and magnetic resonance imaging showed T1-low and T2-high signal intensity with different fluid level. Our impression was an aneurysmal bone cyst. At surgery, the lesion was a blood-filled cystic cavity, surrounded by a gray or brownish tissue. Hemorrhagic soft tissues with recognizable bone fragments were observed. Curettage and autogenous bone graft was done. Microscopically, sheets of tumor cells were intermingled with some areas of eosinophilic chondroid matrix. The tumor cells showed oval-shaped nuclei with moderate eosinophilic cytoplasm. Several multinucleated giant cells and blood filled cystic cavities were observed. The final diagnosis was a chondroblastoma with a secondary aneurysmal bone cyst. At the post-operative 1.5-year follow-up, grafted bones were well incorporated radiographically and there were no recurrent evidence or any other abnormal symptoms.

  1. Inhibition of mTOR and HIF pathways diminishes chondro-osteogenesis and cell proliferation in chondroblastoma.

    Science.gov (United States)

    Yang, Xiao; Yang, Zheng-jie; Liu, Feng-xiang; Zeng, Ke; Qian, Ming-quan; Chen, Gang; Shi, Lei; Zhu, Guo-xing

    2013-10-01

    Chondroblastoma (CBL) is a benign bone tumor occurring mostly in teenagers. Despite this, CBL can recur and metastasize after curettage, which may impede normal epiphysis. In search of a novel targeted therapy for CBL, we aimed at BMP-2, a factor critical for chondro-osteogenesis and chondrocyte proliferation. Two pathways upstream of BMP-2, the mTOR and HIF, were targeted with rapamycin (Rapa) and FM19G11 (FM), respectively. Using immunohistochemistry, we found BMP-2 was highly expressed in CBL tissues. CBL cells explanted and confirmed with higher BMP-2 level than normal cartilage. Protumorigenic effect of Rapa and FM on CBL cells were transduced via BMP-2. Combination of Rapa and FM conferred stronger inhibition of cell proliferation than either monotherapy and inhibited levels of chondro-osteogenic markers (Sox9, aggrecan, and type II collagen). To minimize the adverse effect of Rapa, we performed screening in essential amino acids and found leucine deprivation-sensitized CBL cells to Rapa. Combination treatment of low dose Rapa, FM, and leucine deprivation conferred compatible inhibitory effects on CBL cell proliferation, chondro-osteogenic potential, and tumorigenic capacity. We conclude that targeting BMP-2 using mTOR/HIF inhibition could potently curb the disease. Addition of low-leucine diet could lower the dose of rapamycin in chase for less toxicity.

  2. Chondroblastoma: a clinicopathologic analysis of nine cases%软骨母细胞瘤9例临床病理分析

    Institute of Scientific and Technical Information of China (English)

    唐雪峰; 李龙辉; 许建平; 叶明福

    2012-01-01

    Objective To investigate the clinical, radiologic and pathological features of chondroblastoma, and to identify diagnostic criteria. Methods Nine cases of chondroblastoma from our hospital during the past 8 years were retrospectively analyzed on clinical and pathological features. Results Nine patients ranged in age from 14 to 33 years and mean ages was 19.7, with only 2 patients over 20 years old. The most common anatomic site was femur. The main symptom was less severe local pain. Radiologic examination revealed typically iytic and osteolytic lesions in all cases. Only 1 case was accuratrely diagnosed clinically before the operation. Histologic features of chondroblastoma included 3 components: chondroblastic cells, multinucleated giant cells and cartilage matrix. 7 cases showed S-100 expression. Conclusion The diagnosis of chondroblastoma must be combined with the clinical features, image changes and presents of the three morphological components.%目的 探讨软骨母细胞瘤的临床、影像学和病理形态学特征,明确诊断要点.方法 收集9例有完整临床资料的软骨母细胞瘤病例,对其临床、影像学和病理资料作回顾性分析.结果 9例患者中男性5例,女性4例,发病年龄14 ~33岁,平均年龄19.7岁,>20岁者2例.最常见的发病部位是股骨,主要症状是轻度局部疼痛.影像学上9例均为囊状溶骨性改变,术前只有1例确诊.镜下9例均能观察到软骨母细胞瘤的3种组成成分:软骨母细胞、破骨细胞样巨细胞和软骨基质.9例中7例软骨母细胞S-100(+).结论 软骨母细胞瘤的诊断需结合年龄、部位、影像学特点,并重点把握住软骨母细胞瘤的3种镜下成分.

  3. Mutation Analysis of H3F3A and H3F3B as a Diagnostic Tool for Giant Cell Tumor of Bone and Chondroblastoma.

    Science.gov (United States)

    Cleven, Arjen H G; Höcker, Saskia; Briaire-de Bruijn, Inge; Szuhai, Karoly; Cleton-Jansen, Anne-Marie; Bovée, Judith V M G

    2015-11-01

    Specific H3F3A driver mutations and IDH2 mutations were recently described in giant cell tumor of bone (GCTB) and H3F3B driver mutations in chondroblastoma; these may be helpful as a diagnostic tool for giant cell-containing tumors of the bone. Using Sanger sequencing, we determined the frequency of H3F3A, H3F3B, IDH1, and IDH2 mutations in GCTBs (n=60), chondroblastomas (n=12), and other giant cell-containing tumors (n=24), including aneurysmal bone cyst, chondromyxoid fibroma, and telangiectatic osteosarcoma. To find an easy applicable marker for H3F3A mutation status, H3K36 trimethylation and ATRX expression were correlated with H3F3A mutations. In total, 69% of all GCTBs harbored an H3F3A (G34W/V) mutation compared with 0% of all other giant cell-containing tumors (Pchondroblastomas showed an H3F3B (K36M) mutation compared with 0% of other giant cell-containing tumors (Pchondroblastoma from other giant cell-containing tumors. Although H3K36 trimethylation and ATRX immunohistochemistry cannot be used as surrogate markers for H3F3A mutation status, mutations in H3F3A are associated with increased H3K36 trimethylation, suggesting that methylation at this residue may play a role in the etiology of the disease.

  4. 软骨母细胞瘤20例临床病理分析%Clinicopathological analysis of 20 cases of chondroblastoma

    Institute of Scientific and Technical Information of China (English)

    罗华; 肖秀丽; 蒋堃; 杨志惠

    2015-01-01

    Objective: To study the clinical, patho morphologic, radiographic and immunohistochemical characteristics of chondroblastoma for pathological diagnosis and antidiastole. Methods: 20 patients with chondroblastoma from 1998 to 2014 were retrospectively reviewed. Hematoxylin eosin (HE) staining and immunohistochemical (IHC) staining were applied. Radiographic and clinical were characteristics were reviewed. Results: The disease occurred predominantly in adolescents (mean age 17, 4 cases>20), more common in males (13 men and 7 women). The common location was long bone, particularly tibia, femur and humerus, only 5 cases occurred in other bones. X- ray showed circular or ovoid, expanded, lytic lesion in the epiphysis of bone, often containing irregular calcifications, mostly without periosteal reaction. The lesion usually had a thin sclerotic border. Chondroblastoma with aneurysmal bone cyst occurred in one case. Microscopically, the characteristic findings was abundance of immature eosinophilical chondroid matrixes, hypercellularity of the chondroblasts, and"chicken-wire-like"calcifications. Immunohistochemically, the positive expression of S-100 protein was helpful for correct diagnosis. Conclusions: Understanding of the characteristics of clinicpathology, radiographs, and immunohistochemical markers on chondroblastoma is essential for diagnosis and differential diagnosis of chondroblastoma.%目的:探讨软骨母细胞瘤的临床、影像学、病理形态学和免疫组化特征,明确病理诊断及鉴别诊断。方法:收集我院1998年至2014年经病理证实的20例软骨母细胞瘤,用HE和免疫组化方法进行病理学观察,同时分析其临床和影像学特点。结果:20例患者中男性13例,女性7例,多发于青少年,平均年龄17岁,>20岁者4例。最常见的部位是长骨(75%),尤其是股骨、胫骨和肱骨,其他部位5例。 X线通常表现为骨骺或骨突部位圆形或卵圆形地图状溶骨性骨质

  5. Value Comparision of X-ray and CT Diagnosis Chondroblastoma%X线与CT诊断成软骨细胞瘤的价值对照

    Institute of Scientific and Technical Information of China (English)

    苏循玉

    2015-01-01

    Objective To compare and analyze diagnosis value of X-ray and CT for chondroblastoma. Methods 30 cases patients with chondroblastoma in our hospital were choosed, and car ied out X-ray and CT examination respectively. Analyzing the result of two diagnosis. Results X-ray showed lesions on circular or irregular shape of the limitations bone destruction area, while CT display lesions of varying degrees lobulated shape, and lead to half annular calcification, boundary is clear. The two diagnosis were compared, the diagnosis sensitivity of X-ray and CT is al higher, the dif erences had no statistical significance ( >0.05);But the specificity of CT diagnosis is significantly higher than X-ray, the dif erence was statistical y significant ( <0.05). Conclusion X-ray and CT in the diagnosis of into cartilage cel s, they have their own excel ence, but the specificity of the CT diagnosis is bet er than X-ray diagnosis, in the clinical, joint two diagnosis methods can provide more diagnostic information, which play a important role in diagnosis and identify of chondroblastoma.%目的:对比分析X线与CT诊断成软骨细胞瘤的价值。方法选择我院成软骨细胞瘤患者30例,分别行X线与CT检查。分析诊断结果。结果 X线显示病灶为圆形或者不规则形的局限性骨破坏区,而CT显示病灶为不同程度的分叶状,半环形钙化,边界比较清晰。两者诊断结果比较,X线和CT诊断的敏感性都较高,两者比较差异无统计学意义(>0.05);但是CT诊断的特异性显著高于X线诊断的特异性,两者比较差异有统计学意义(<0.05)。结论 X线与CT在诊断成软骨细胞时各有自身的优点,但是CT诊断的特异性优于X线诊断,在临床诊断中联合两种诊断方式能提供更多的诊断信息,对成软骨细胞的诊断和鉴别具有非常大的作用。

  6. A balanced t(5;17 (p15;q22-23 in chondroblastoma: frequency of the re-arrangement and analysis of the candidate genes

    Directory of Open Access Journals (Sweden)

    Wijers-Koster Pauline

    2009-11-01

    Full Text Available Abstract Background Chondroblastoma is a benign cartilaginous tumour of bone that predominantly affects the epiphysis of long bones in young males. No recurrent chromosomal re-arrangements have so far been observed. Methods: We identified an index case with a balanced translocation by Combined Binary Ratio-Fluorescent in situ Hybridisation (COBRA-FISH karyotyping followed by breakpoint FISH mapping and array-Comparative Genomic Hybridisation (aCGH. Candidate region re-arrangement and candidate gene expression were subsequently investigated by interphase FISH and immunohistochemistry in another 14 cases. Results A balanced t(5;17(p15;q22-23 was identified. In the index case, interphase FISH showed that the translocation was present only in mononucleated cells and was absent in the characteristic multinucleated giant cells. The t(5;17 translocation was not observed in the other cases studied. The breakpoint in 5p15 occurred close to the steroid reductase 5α1 (SRD5A1 gene. Expression of the protein was found in all cases tested. Similar expression was found for the sex steroid signalling-related molecules oestrogen receptor alpha and aromatase, while androgen receptors were only found in isolated cells in a few cases. The breakpoint in 17q22-23 was upstream of the carbonic anhydrase × (CA10 gene region and possibly involved gene-regulatory elements, which was indicated by the lack of CA10 protein expression in the index case. All other cases showed variable levels of CA10 expression, with low expression in three cases. Conclusion We report a novel t(5;17(p15;q22-23 translocation in chondroblastoma without involvement of any of the two chromosomal regions in other cases studied. Our results indicate that the characteristic multinucleated giant cells in chondroblastoma do not have the same clonal origin as the mononuclear population, as they do not harbour the same translocation. We therefore hypothesise that they might be either reactive or

  7. Imaging Manifestation and Pathological Analysis of Chondroblastoma%软骨母细胞瘤的影像学表现与病理分析

    Institute of Scientific and Technical Information of China (English)

    卢超; 徐盛; 张国庆

    2011-01-01

    Objective To study X-ray, CT and MRI manifestations and pathological features of chondroblastoma. Methods Images of 12 caseswith chondroblastoma proved pathologically were retrospectively analyzed. X-ray plain film examination was performed to all cases. CT detection was performed to 8 cases, and MRI was performed to 7 cases. Results Among 12 cases, X-ray plain films of 10 cases showed well-defined lesions, sclerotic boundary in surroundings and stippled and patchy calcification in lesions. CT images showed lesions, sclerotic boundary and stippled and patchy calcification clearly in 8 cases and periosteal reaction and soft tissue swelling in 5 cases. MRI showed well-defined lesions, low signal on Tl WI and slightly mixed signal on T2WI in 7 cases and bone marrow edema in 4 cases. Obvious enhancement was detected in 7 patients who underwent contrast enhanced MRI. Conclusion Chondroblastoma has certain characteristics in the X-ray, CT and MRI appearance and pathology manifestation. It is helpful to make correct diagnosis by analyzing X-ray, CT, MRI appearance comprehensively.%目的 探讨软骨母细胞瘤的X线、CT和MRI表现以及病理学特点.方法 回顾性分析12例经病理证实的软骨母细胞瘤的影像学资料,12例均行X线平片检查,其中8例经CT检查,7例经MRI检查.结果 12例中,10例X线平片示病灶边界清楚,周围可见硬化边,病灶内可见斑点状和斑片状钙化.8例CT均清楚显示病灶及硬化边,均可见斑点状和斑片状钙化,5例可见骨膜反应和软组织肿胀.7例MRI均清楚显示病灶边缘,T1WI低信号,T2WI混杂信号,4例可见骨髓水肿,7例均做增强扫描病灶呈明显强化.结论 软骨母细胞瘤的X线、CT和MRI征象和病理学表现具有一定的特征性,综合分析X线、CT和MRI征象有助于正确诊断.

  8. 少见部位软骨母细胞瘤的影像诊断%Imaging diagnosis of chondroblastoma in unusual locations

    Institute of Scientific and Technical Information of China (English)

    戴灼南; 司建荣

    2012-01-01

    Objective:To investigate the imaging features and their value in the diagnosis of chondroblastoma in unusual locations. Methods:The clinical materials of 7 cases with pathology proved chondroblastoma in unusual locations were retrospectively analyzed,involving talus (n=2) .calcaneus (n = 2) ,patella,ischial tuberosity and inferior ramus of pubis for one case each. In these 7 patients, plain radiography (n= 7) ,computed tomography (n=4) and magnetic resonance imaging (n=4) were performed. Results:Expansive bone destruction (n=5) and cystic bone destrution (n= 1) were assessed on radiography, also patchy sclerosis around the lesion (n=3) and intra-tumoral spotty calcifications (n=l). Of the 4 cases undergone CT, there were expansive bone destruction, patchy sclerosis around the lesion and intra-tumoral patchy or spotty calcifications. Expansive bone destruction were showed in 3 cases on MRI with heterogeneous signal intensities. peripheral linear hypo-intensity and obvious bone marrow edema. Conclusion; Imaging features of chondroblastoma in unusual locations included expansive destruction of bone,and peripheral bone marrow edema. Combined utilization of plain films,CT and MRI is helpful for the diagnosis and differential diagnosis of chondroblastoma in unusual locations.%目的:探讨少见部位软骨母细胞瘤的影像学表现及其临床诊断价值.方法:回顾性分析经病理证实的7例少见部位软骨母细胞瘤患者的病例资料.肿瘤位于距骨2例、跟骨2例、髌骨、坐骨结节及耻骨下支各1例.行X线平片检查7例,CT平扫4例,MRI平扫及增强检查4例.结果:X线平片示膨胀性骨质破坏5例,囊状骨质破坏1例,灶周硬化3例,病灶内小斑片状钙化1例;平片漏诊1例.4例CT均显示膨胀性骨质破坏,灶周硬化,病灶内斑点状或小斑片状钙化.MRI上病变呈膨胀性骨质破坏3例,囊状骨质破坏1例,4例病灶信号均混杂,灶周均可见低信号线状影及明显的骨髓水肿.结

  9. 软骨母细胞瘤的影像学诊断与临床分析%Imaging analysis of 20 cases of chondroblastoma

    Institute of Scientific and Technical Information of China (English)

    韩志巍; 李振武; 袁怀平; 唐永强; 张崴琪; 郭宁; 印弘; 张劲松

    2015-01-01

    Objective To assess the role of radiography ,computed tomography and magnetic resonance imaging in the a‐nalysis of 20 patients with chondroblastoma ,and to analyze its pathologic basis .Methods The imaging results were retro‐spectively analyzed in 20 patients with chondroblastoma confirmed by pathology ,and compared with pathological section . Results 17 cases located at epiphysis of long bone .Expanding and window‐like changes were found 12 cases ,centric growth in 10 cases ,and eccentric in 10 .All the lesions presented with clearly visible edge ,13 lesions showed sclerotic rim ,11 leisons involved the articular surface ,and 4 were abarticular .Calcification was found in 11 lesions ,articular cavity hydrops in 5 ,bone marrow edema in 2 .Only one showed soft tissue mass .Conclusion The imaging appearances of chon‐droblastoma has some characteristics ,and is related to its pathologic basis and understanding this is helpful to improve the diagnosis coincidence rate .%目的:分析20例软骨母细胞瘤的影像学表现,对比X线片、C T以及M RI图像上的差异,分析其与病理的关系。方法对20例经手术病理证实的软骨母细胞瘤的影像学及病理资料进行回顾性分析,对同一影像表现在不同影像学图像上的征象差异进行对照研究。结果发生在长骨骨端的病变共17例,12例有膨胀性与窗格样改变,10例中心性生长,10例偏心性生长。病灶边界清楚,13有硬化边,11例累及关节面,4例位于关节面以远,17例破坏区内有钙化灶,5例有关节腔积液,5例有骨髓水肿,1例伴软组织肿块。结论软骨母细胞瘤有特征性影像学表现,并且与病理学有一定的关系,了解这些有助于提高本病的诊断符合率。

  10. Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone.

    Science.gov (United States)

    Behjati, Sam; Tarpey, Patrick S; Presneau, Nadège; Scheipl, Susanne; Pillay, Nischalan; Van Loo, Peter; Wedge, David C; Cooke, Susanna L; Gundem, Gunes; Davies, Helen; Nik-Zainal, Serena; Martin, Sancha; McLaren, Stuart; Goody, Victoria; Goodie, Victoria; Robinson, Ben; Butler, Adam; Teague, Jon W; Halai, Dina; Khatri, Bhavisha; Myklebost, Ola; Baumhoer, Daniel; Jundt, Gernot; Hamoudi, Rifat; Tirabosco, Roberto; Amary, M Fernanda; Futreal, P Andrew; Stratton, Michael R; Campbell, Peter J; Flanagan, Adrienne M

    2013-12-01

    It is recognized that some mutated cancer genes contribute to the development of many cancer types, whereas others are cancer type specific. For genes that are mutated in multiple cancer classes, mutations are usually similar in the different affected cancer types. Here, however, we report exquisite tumor type specificity for different histone H3.3 driver alterations. In 73 of 77 cases of chondroblastoma (95%), we found p.Lys36Met alterations predominantly encoded in H3F3B, which is one of two genes for histone H3.3. In contrast, in 92% (49/53) of giant cell tumors of bone, we found histone H3.3 alterations exclusively in H3F3A, leading to p.Gly34Trp or, in one case, p.Gly34Leu alterations. The mutations were restricted to the stromal cell population and were not detected in osteoclasts or their precursors. In the context of previously reported H3F3A mutations encoding p.Lys27Met and p.Gly34Arg or p.Gly34Val alterations in childhood brain tumors, a remarkable picture of tumor type specificity for histone H3.3 driver alterations emerges, indicating that histone H3.3 residues, mutations and genes have distinct functions.

  11. Diagnosis and treatment of patellar chondroblastoma%髌骨软骨母细胞瘤诊断及治疗进展

    Institute of Scientific and Technical Information of China (English)

    程强; 黄伟

    2013-01-01

    髌骨软骨母细胞瘤(chondroblastoma of patella)是一种发生在髌骨的少见的良性骨肿瘤,相对于骨巨细胞瘤,其在髌骨的发病率更低.同时,该肿瘤临床表现多样,可表现出各种复杂的影像学特征.因此,即使专业的骨科医生对其认识仍有可能不足.髌骨软骨母细胞瘤在X线片、CT及MRI上与骨巨细胞瘤等肿瘤的鉴别是近年来的研究焦点之一.有时它与动脉瘤样骨囊肿可合并存在,这就对进行准确的病理及影像学诊断提出了更进一步的挑战.在治疗上,病灶刮除植骨术是目前主流的手术方法,但对于是否需要在术前进行活检仍存在争议.此外,新的射频消融等技术用于治疗的前景到底如何仍未可知.

  12. The imaging features of the chondroblastoma in the tarsal bone%足跗骨软骨母细胞瘤的影像学表现

    Institute of Scientific and Technical Information of China (English)

    彭俊红; 周利华; 黄利华; 王慧明; 阮学广

    2012-01-01

    目的:总结分析足跗骨软骨母细胞瘤的影像学表现.方法:回顾性分析经临床病理证实的发生于足跗骨的5例软骨母细胞瘤的X线、CT及MRI表现.结果:5例均单发,2例位于跟骨,2例位于距骨,1例位于舟骨.X线主要表现为圆形或卵圆形透亮影,边界清楚,5例均可见病灶边缘硬化带形成,病灶内未见明显钙化.CT扫描显示肿瘤呈膨胀性生长,骨质破坏区边界锐利、硬化,灶周软组织肿胀,未见骨膜反应及软组织肿块,增强扫描呈轻度不均匀强化.MRI可见病灶形态呈分叶状,呈长、稍长T1信号,混杂T2信号,伴有灶周骨髓水肿及关节腔积液,灶周软组织水肿,增强扫描亦呈轻度不均匀强化.结论:足跗骨软骨母细胞瘤较少见,其影像学表现具有一定特征性.%Objective:To analyze the imaging features of the chondroblastoma in the tarsal bone,and enhance the com petence of diagnosis. Methods:The X ray,CT and MRI imaging of 5 cases with pathology proved chondroblastoma which were located in the tarsal bone were retrospectively analyzed. Results:Of all the 5 cases,the locations of tumors were as fol forws:calcaneus(n=2),talus(n=2),navicular bone (n=1).The main radiographic manifestations were round or oval translucent area witn well delined margin, sclerotic rim,and no calcilications in all lesions. On CT scan,thee tumor demon strated expansive growth patterns,by showing well defined bone destruction with sclerosis rim. The adjacent soft tissue ede ma,without periosteal reaction and soft tissue masses were observed. The contrast enhancement was mild. Lesions demon strated heterogeneous MR signal intensity on T1WI and T2 WI. Lobular margins,adjacent bone marrow edema and joint ef fusion were found. The contrast enhancement was mild too. Conclusion: Characteristic imaging features could be revealed in the uncommon cnondroblastoma of the tarsal bone,which were helpful in the diagnosis.

  13. The Correlation between MRI Manifestations and Pathologic Findings of Chondroblastoma%软骨母细胞瘤的MRI表现特征及其病理基础

    Institute of Scientific and Technical Information of China (English)

    于爱红; 顾祥; 陈祥述; 屈辉; 程晓光

    2010-01-01

    目的 探讨软骨母细胞瘤(chondroblastoma,CB)的MRI表现特点及其病理基础.资料与方法 分析经手术病理证实的13例CB的MRI表现特征,并与病理切片进行对照研究.结果 全部病例在T1WI、T2WI上呈混杂信号.7例病灶边缘在T1WI及T2WI上均可见低信号环.9例有病灶邻近软组织肿胀和(或)关节囊肿胀.8例病灶周围骨髓腔内见水肿带.12例增强扫描均有不均匀明显强化.病理镜下主要由软骨母细胞和大小不等的多核巨细胞组成;7例肿瘤细胞间可见致密粗颗粒状钙盐沉积.6例可见含有暗红色液体囊腔,以及含铁血黄素沉着和组织凝固坏死.结论 CB的MRI表现较具特征性,MRI能反映其病理特性,是诊断CB的重要影像学方法.

  14. 软骨母细胞瘤67例临床病理分析%Chondroblastoma of bone: a clinicopathological analysis of 67 cases

    Institute of Scientific and Technical Information of China (English)

    方三高; 肖蔚; 周航波; 周晓军

    2011-01-01

    Objective To analyze the morphological characteristics, image features, treatments and diagnosis of chondroblastotna. Methods The pathological features were explored with HE and immunohistochemical staining in 67 cases of chondroblastoma. The image manifestations were studied with plain X-ray film, CT and MRI. Results It occurred predominantly in adolescents (mean age, 19 years), more commonly in males (male/female =3. 2; 1.0). Preferred sites were the epiphyses or apophyses of the long bones, especially in the femoral great trochantere (22/67, 32. 84% ). In this group, lesions were located at femurs in 37 patients (55. 22% ) ; tibia in 12 ( 17. 91% ) ; talus and pelvis each in 3; humeri, costae, vertebrae, calcaneus and patella each in 2 and sacrum and infraturbinal each in 1. On plain radiograph, it depicted as an ovoid lesion with well defined osteolytic destruction and thin sclerotic margin. CT was optimal to detect the tumors that appeared as low density area of bone with patchy and stippled calcification, periosteal reaction, soft tissue swelling and cystic changes. MRI imaging demonstrated iso-and hypo-intense on T1WI and heterogeneous signals on T2WI. Histologically, one of the most characteristic findings in chondroblastomas was so called "chicken-wire-like calcification" that assuming a grid pattern of tiny calcific bodies which enveloped the cells. However, it was only 31 cases (46. 27% ) in this group, compared with polygonally-shaped mononuclear cell with a grooved nuclei intermixed by eosinophilical chondroid matrixes and local narcoses. Immunohistochemically, among 45 cases, the strong positive case for S-100 protein was 45. Meanwhile, modest positive case for D2-40 was 9 and weak positive case was 11 in another 26 cases. And few tumor cells were high level expression for Ki-67 except for cases of 5 (the positive rate <5% ). Conclusion Chondroblastoma of bone is a rare, benign cartilaginous neoplasm. Apart from chicken-wire-like calcification, more

  15. 股骨头软骨母细胞瘤的诊断与治疗%Diagnosis and treatment of chondroblastoma of the femoral head

    Institute of Scientific and Technical Information of China (English)

    李远; 邓志平; 杨发军; 王涛; 牛晓辉

    2009-01-01

    目的 探讨股骨头软骨母细胞瘤的诊断及治疗方法.方法 对1999年2月至2008年3月收治的13例股骨头软骨母细胞瘤病例的诊断和治疗进行回顾性分析,男8例,女5例;年龄9~29岁,平均17.9岁.术前Hartis评分平均为67分(38~78分).所有患者术前经详细的影像学评估后行手术治疗.术前活检3例,术中冰冻病理检查2例.所有最终诊断以术后病理为准.所有患者行前侧Smith-Peterson入路经股骨头圆韧带止点开窗行肿瘤刮除植骨术,自体骨植骨7例,异体骨植骨5例,自体骨加异体骨混合植骨1例.结果 13例均获得随访,中位随访时间26个月(6~84个月).所有患者随访期间无肿瘤复发.1例自体骨植骨患者术后2个月部分负重后出现股骨头塌陷坏死,6个月后改行股骨头切除人工全髋关节置换.其余患者功能良好,术后Harris评分平均88分(69~98分),较术前提高21分.自体骨植骨患者平均骨愈合时间5.3个月(3~11个月),异体骨植骨患者6.8个月(3~13个月),混合植骨患者4个月.结论 股骨头软骨母细胞瘤是一种少见肿瘤,有独特的临床及影像学特征.髋关节前侧Smith-Peterson入路经股骨头圆韧带止点开窗肿瘤刮除植骨术是一种有效的治疗方案.术后植骨愈合前避免负重,并进行免负重髋关节功能锻炼,可以提高治疗效果.%Objective To investigate the diagnostic and therapeutic methods of chondroblastoma of the femoral head. Methods The thirteen consecutive patients with chondroblastomas of the femoral head were evaluated between February 1999 and March 2008 retrospectively. There were eight males and 5 females. The mean age was 17.9 years (range, 9-29 years).The mean Harris Score before surgery was 67 (range, 38-78). All patients were evaluated by detailed imaging studies before surgery. Biopsy was performed in three patients. Frozen section histology during surgery was performed in another two patients. All the

  16. 膝关节周围骨巨细胞瘤与软骨母细胞瘤影像表现分析%Imaging appearances of giant cell tumor of bone and chondroblastoma around the knee.

    Institute of Scientific and Technical Information of China (English)

    于宝海; 韩奕; 刘记存; 彭志刚; 吴文娟

    2013-01-01

    Objective To study imaging differential diagnosis of giant cell tumor and chondroblastoma of bone around the knee. Methods 32 cases with giant cell tumors of bone and 10 cases with chondroblastomas of distal femur or proximal tibia were collected. The common imaging signs( including 16 findings) were analysed statistically. Results In the 16 imaging findings, the incidences of intratumoral calcification, lobulatcd sign, the tumor's long axis consistent with sick bone long axis, and transverse diameter of the lesions to be large than that of the sick bone over 1/2 were statistically significant between two tumors. The incidences of first two findings above in chondroblastoma were higher than that in giant cell tumor of bone, and the latter two findings above were opposite. The rest twelve imaging signs were not of statistical difference between them. Conclusion Intratumoral calcification, lobulatcd sign, the ratio between the tumor and sick bone in diameter can be valuable imaging signs in differential diagnosis of giant cell tumor and chondroblastoma around the knee.%目的 探讨膝关节周围骨巨细胞瘤与软骨母细胞瘤的影像学鉴别诊断.方法 采用本院收集的并经病理证实的股骨远端和胫骨近端的32例骨巨细胞瘤和10例软骨母细胞瘤,统计常见的16种征象,对其进行统计学分析.骨巨细胞瘤26例行X线检查,25例行CT检查,18例行MRI检查;软骨母细胞瘤全部行X线检查,8例行CT检查,7例行MR检查.结果 16种征象中,瘤内钙化、分叶、病变长轴与载瘤骨长轴一致、病变横径大于载瘤骨直径1/2在二者发生率分别具有统计学意义.前二者在软骨母细胞瘤的出现率大于骨巨细胞瘤,后二者相反.其余的12种征象的发生率无统计学意义.结论 瘤内钙化、分叶、病变长轴与母骨长轴一致、病变横径大于母骨直径1/2、病灶边缘到关节面的距离可以作为膝关节周围骨巨细胞瘤与软骨母细胞瘤具有统计学意义的鉴别征象.

  17. p63蛋白在软骨母细胞瘤中的表达及其价值探讨%Expression of p63 in chondroblastoma and its application in pathological diagnosis

    Institute of Scientific and Technical Information of China (English)

    刘珺; 陈丽荣

    2012-01-01

    目的 探讨p63蛋白在软骨母细胞瘤中的表达水平及其诊断价值.方法 采用免疫组织化学法(Maxvision)技术对25例软骨母细胞瘤、52例骨巨细胞瘤、10例动脉瘤样骨囊肿和20例腱鞘巨细胞瘤中p63和S-100p蛋白的表达水平进行分析.结果 p63蛋白在软骨母细胞瘤中呈单核细胞的胞核阳性,阳性率为88.0%( 22/25).而骨巨细胞瘤中除呈单核细胞的胞核阳性,少数多核巨细胞的胞核亦呈阳性,阳性表达率为92.3% (48/52).p63蛋白在软骨母细胞瘤和骨巨细胞瘤中的表达两者比较差异无统计学意义(P>0.05),而S-100p在软骨母细胞瘤和骨巨细胞瘤中阳性表达率分别为88.0%( 22/25)和1.9% (1/52),两者差异有统计学意义(P<0.05).p63蛋白和S-100p在动脉瘤样骨囊肿和腱鞘巨细胞瘤中均不表达.结论 p63蛋白在软骨母细胞瘤和骨巨细胞瘤中均呈高表达,并有相似的免疫表型,提示两者在发生分化上可能均来自相同的起源细胞或肿瘤干细胞.p63蛋白结合S-100p联合应用对鉴别软骨母细胞瘤及其相关性病变具有一定辅助诊断意义.%Objective To evaluate the expression of p63 in chondroblastoma and its clinicopathological significance. Methods The expression of p63 and S-lOOp was examined by Maxvision immunohistochemical method in paraffin-embedded tissue specimens, including 25 cases of chondroblastoma,52 cases of giant cell tumor of bone,20 cases of giant cell tumor of tendon sheath and 10 eases of aneurysmal bone cyst. Results Immunohistochemical staining showed- that p63 protein was expressed in the nucleus of neoplastic mononuclear cells of 22 cases of chondroblastoma (88. 0%) ; in the nucleus of neoplastic mononuclear cells and scatteredly in the nucleus of multinucleated cells of 48 cases of giant cell tumor of bone (92. 3%). There was no statistical difference between the two types of tumors (P >0.05). Positive rates of S-lOOp protein in chondroblastomas and

  18. 软骨母细胞瘤MRI及X线平片和CT的表现特征%The MRI features of chondroblastoma with correlation of X-ray and CT findings

    Institute of Scientific and Technical Information of China (English)

    上官景俊; 刘吉华; 韩娟娟; 邢成颜

    2008-01-01

    目的 研究软骨母细胞瘤的影像表现,探讨其MRI与X线平片、CT征象的对应关系.方法 分析16例经手术、病理证实的良性软骨母细胞瘤的影像资料,总结其MRI表现与X线平片、CT征象的对应关系.结果 16例软骨母细胞瘤均位于骨骺,大小为0.9 cm×0.8 cm×1.0 cm~4.8 cm×4.3 cm×5.1 cm,呈不同程度的分叶状.在T1WI上以等、低信号为主,T2WI上呈混杂信号,CT上为软组织密度,内见钙化和更低密度区.边缘呈长T1、短T2信号,在CT上表现为硬化边.MRI可见病灶周围有骨髓水肿,在X线和CT上表现为骨质硬化区.病灶邻近软组织肿胀.MRI显示骨膜异常9例,8例与病灶不相邻;X线和(或)CT显示骨膜新生骨6例.MRI显示关节积液12例,CT显示6例.MRI上病灶均呈不均匀强化,骨髓水肿、骨膜反应和软组织肿胀均见强化.软骨母细胞瘤在扩散加权成像(DWI)上呈等、高信号,在MR平扫中的等T1、等T2成分和长T1、长T2成分,以及骨髓水肿、骨膜反应和软组织肿胀在DWI上均呈高信号.结论 MRI和X线平片、CT从不同方面反映软骨母细胞瘤的病理改变,联合应用不同检查手段可更全面显示软骨母细胞瘤的特点.%Objective To investigate the MR imaging features of chondroblastoma,and to address the correlation with findings of X-ray radiography and CT.Methods The imaging findings including MRI,X-ray radiography and CT of 16 chondroblastomas proved by surgery and pathology were analyzed and correlated with each other. Results All sixteen chondroblastomas involved the epiphyses of long bones,with varying sizes from 0.8 cm to 5.1 cm and lobulation. They were iso- and hypo-intense on T1WI and had heterogeneous signals on T2WI.They were of soft tissue density on CT,and had areas of calcifications and low density.The rims were hypointense on both T1 WI and T2 WI and showed hyperdensity on CT. The lesions were surrounded by edema of bone marrow which was hypointense on T1 WI

  19. Comparative Analysis of CT and MRI Imaging Findings of Chondroblastoma%软骨母细胞瘤的CT及MRI影像表现对比分析

    Institute of Scientific and Technical Information of China (English)

    韩宏声

    2016-01-01

    目的:比较软骨母细胞瘤的CT及MRI影像表现。方法纳入我院2011年1月-2015年12月期间共收集36例软骨母细胞瘤患者进行研究,均行CT及MRI检查,比较二者对软骨母细胞瘤临床诊断的价值。结果 CT表现以病灶边缘硬化、病灶内钙化、骨膜反应、软组织肿胀、邻近关节腔积液为主,增强扫描后病灶内均示轻度到中度强化,CT值增高8-34HU。MRI示病灶多为卵圆形或类圆形囊状骨质破坏区、边界清晰,T1WI低信号、T2WI高低混杂信号,特殊征象包括片状、斑点状低信号钙化或骨嵴、病灶边缘低信号硬化带、T2WI病灶周围骨髓腔见长T2水肿信号。两种检查方法对膨胀性病变、窗格样改变、骺板或骺线穿越等征象的检出率无统计学意义(P>0.05);CT对边界清晰伴边缘硬化、病灶内钙化检出率分别为61.1%、66.7%,高于MRI的36.1%、41.7%,对骨髓水肿检出率仅为2.8%,低于MRI的27.8%,差异均有统计学意义(P0.05); The detection rates of CT for clear boundary with marginal sclerosis and calcification within the lesions (61.1%, 66.7%) were higher than those of MRI (36.1%, 41.7%) while the detection rate for bone marrow edema (2.8%) was lower than that of MRI (27.8%) (P<0.05).Conclusions CT and MRI in the diagnosis of chondroblastoma have their own advantages and disadvantages. CT can better show marginal sclerosis and calcification within the lesions while is poorer in displaying bone marrow edema. In clinical diagnosis, it needs to be identified from bone giant cell tumor, chondrosarcoma and chondroma etc..

  20. X 线与 CT 诊断对成软骨细胞瘤的诊断价值分析%Diagnostic value of X-ray and CT in diagnosis of chondroblastoma

    Institute of Scientific and Technical Information of China (English)

    税永平

    2013-01-01

    Objective X-ray and CT diagnostic value of chondroblastoma were discussed, and improve the imaging diagnostic level . Methods in January 2009-2013 in our hospital between January by X-ray or CT diagnosis of 62 cases of chondroblastoma patients were randomly divided into X-ray plain film in the diagnosis of group (group A) and the CT group (group B), each group of 31 cases, ultimately, all cases of surgical treatment and confirmed by pathology. Results A group of 31 patients, preoperative diagnosis of chondroblastoma 18 cases, 8 cases diagnosed as giant cell tumors of bone, cartilage myxoid fibroma, 4 cases were diagnosed as tumor, 1 case was diagnosed as bone X-ray diagnosis accuracy rate 58%, the misdiagnosis rate was 42% in group B, 31 patients, preoperative diagnosis of chondroblastoma 25 cases, 3 cases were diagnosed as aneurysm bone cyst, 2 cases were diagnosed as giant cell tumors of bone, 1 case was misdiagnosed as fibrosarcoma, CT diagnostic accuracy of 80%, the misdiagnosis rate 20% X-ray showed lesions were round or irregular limitations of bone destruction area, CT showed lesions with different degree of lobulated, border and clear, half annular calcification. Conclusion due to the density resolution higher than X-ray plain film, CT can discern subtle bone destruction, and can be found that damage zone calcifications, and to destroy the organization composition CT value in the measurement, so the diagnostic accuracy of chondroblastoma is significantly higher than X-ray plain film, worthy of clinical popularization and application.%目的:对 X 线与 CT 诊断成软骨细胞瘤的价值进行探讨,提高对本病影像诊断水平。方法将2009年1月至2013年1月间在我院经 X 线或 CT 诊断的62例成软骨细胞瘤患者随机分为 X 线平片诊断组(A 组)和经 CT 诊断组(B 组),每组各31例,所有病例最终均行手术治疗并经病理证实。结果 A 组31例患者,术前诊断为成软骨细胞瘤18例,8

  1. X线与CT诊断对成软骨细胞瘤的诊断价值对比分析%Comparative analysis of X-ray and CT diagnosis of chondroblastoma

    Institute of Scientific and Technical Information of China (English)

    杨旭华; 刘晓梅

    2012-01-01

    Objective To investigate the comparative value of X-ray and CT diagnosis of chondroblastoma and to improve the level of diagnosis of this disease. Methods 32 patients with chondroblastoma from June 2002 to March 2011 were selected to do the X-ray and CT scan. Results X-ray showed that the lesions were round or irregular in shape limitations of bone destruction, CT showed the lesions were va-ryed degrees of lobulated border and clear,semi-annular calcification. According to the pathological findings,the sensitivity of X-ray diagnostic was 96. 2% , specificity was 16. 7% ; the sensitivity and specificity of CT diagnostic were respectively 96. 8% and 100. 0% . The two sets of diagnostic sensitivity were relatively high and had no significant difference. But the specificity of CT in the diagnosis was significantly higher than the X-ray diagnosis ( P <0. 05 ). Conclusion Both the X-ray and CT scan diagnosis of chondroblastoma have its own advantages, but the specificity of CT is better, combination of the two can provide more diagnostic information in clinical applications, which is value to the diagnosis and differential diagnosis.%目的 探讨X线与CT诊断对成软骨细胞瘤的诊断价值,提高对本病的诊断水平.方法 收集2002年6月至2011年3月拟诊断为成软骨细胞瘤患者32例,均行X线和CT检查.结果 X线显示病灶均为圆形或不规则形局限性骨破坏区,CT显示病灶呈不同程度的分叶状,边界清楚,半环形钙化.以病理结果 为标准判断,X线诊断的敏感性为96.2%,特异性为16.7%,CT的诊断敏感性与特异性分别为96.8%和100.0%.两种检查方法 诊断的敏感性均较高,对比无明显差异.但是CT诊断的特异性明显高于X线诊断(P<0.05).结论 成软骨细胞瘤的X线诊断与CT诊断各具优势,但是CT诊断的特异性更好,在临床应用中两者相结合能够提供更多的诊断信息,有利于本病的诊断与鉴别诊断.

  2. 成软骨细胞瘤应用X线与CT的临床诊断评价%Clinical Diagnostic Evaluation of Chondroblastoma with X-ray and CT Scanning

    Institute of Scientific and Technical Information of China (English)

    李爱芝

    2014-01-01

    目的:分析X线与CT扫描技术在成软骨细胞瘤应用中的临床疗效,并进行整体的比较观察。方法:选取2013年1月-2014年2月笔者所在医院收治的成软骨细胞瘤患者30例,均进行X线与CT扫描,观察两组在X线与CT扫描状态下的整体情况。结果:通过对30例患者的观察,其中,X线显示中,成软骨细胞瘤的病灶主要表现为圆形或者不规则的呈现出局限性骨破坏区,而CT显示中,病灶呈不同程度的分叶状,在边界相对清晰,呈现出半环形的钙化形式。从整个病理结果的分析来看通过病例检查,30例患者中确诊为成软骨细胞瘤的患者27例,排除3例。X线诊断呈阳性患者21例,排除9例,1例误诊为阴性,7例误诊为阳性;CT扫描诊断呈阳性患者28例,排除2例,有1例误诊呈阴性。其中,X线诊断的敏感性为96.8%(30/31),特异性为12.5%(1/8),CT诊断的敏感性与特异性也分别表现为97.4%(37/38)和100%(1/1),数据采用来源临床运用数据。但是,从诊断的特异性来看,CT诊断要明显高于X线扫描,有一定的差异性。结论:在对成软骨细胞瘤的临床诊断中,采用X线与CT扫描都具有一定的优势,其中CT扫描的特异性更加占据优势,在临床诊断中能提供更加详实的数据,有利于整个病的诊断与鉴别,具有一定的优越性。%Objective:To analyze the effect of X-ray and CT scanning technique in the clinical application of chondroblastoma,and overall comparative observation.Method:Collected from January 2013 to February 2014 in our hospital 30 cases of chondroblastoma,they were given X-ray and CT scanning,two groups were observed in the X-ray and CT scanning state of the overall situation.Result:Through the observation,30 cases,X-ray,chondroblastoma lesions mainly showed round or irregular showed limited bone destruction,CT display showed different degrees of lobulated,in the relative

  3. 足跟骨软骨母细胞瘤的影像诊断及鉴别诊断%Chondroblastoma of Calcaneus in Radiological Findings And the Differential Diagnosis

    Institute of Scientific and Technical Information of China (English)

    任成龙; 马光明; 韩东; 魏伟; 段海峰; 贺太平

    2015-01-01

    目的:探讨足跟骨软骨母细胞瘤(Chondroblastoma,CB)的影像表现.材料与方法:回顾性分析经临床病理证实的12例足跟骨软骨母细胞瘤的X线、CT及MRI影像表现.结果:12例跟骨软骨母细胞瘤均表现为边界清晰、伴有硬化边、偏心性生长、膨胀感不明显的肿块;8例子X线可见片絮状钙化,7例CT可见砂砾状钙化,1例可见网格状分隔;3例CT表现为硬化边不完整,边缘毛刺;MRI示12例T1WI低于脂肪信号,稍高于肌肉信号伴硬化边明显,T2WI信号不均匀,坏死囊变呈高信号,钙化呈高信号.2例出现滑膜囊积液及骺软骨板增厚.结论:足跟骨软骨母细胞瘤影像学表现具有一定特征,结合X线、CT及MRI影像表现,有助于诊断及鉴别诊断.

  4. Resultado do acompanhamento clínico-radiológico pós-cirúrgico do condroblastoma Results from clinical and radiological follow-up, after surgical treatment of chondroblastoma

    Directory of Open Access Journals (Sweden)

    Valter Penna

    2011-10-01

    Full Text Available OBJETIVO: Avaliar o resultado clínico e radiológico, a longo prazo, de pacientes submetidos ao tratamento cirúrgico do condroblastoma, entre 2003 e 2009, pela mesma equipe cirúrgica e empregando a mesma técnica operatória. MÉTODOS: Foi realizado estudo retrospectivo de 12 pacientes com diagnóstico histológico de condroblastoma, atendidos entre 2003 e 2009, na Fundação Pio XII (Hospital de Câncer de Barretos - Barretos, SP e submetidos ao tratamento cirúrgico com ressecção intralesional, adjuvância com eletrocauterização e substituição por metilmetacrilato (11 casos ou enxerto ósseo autólogo de crista ilíaca (um caso. A avaliação pré-operatória incluía exame físico, radiografias simples do local, ressonância nuclear magnética ou tomografia axial computadorizada local, além de cintilografia óssea. Os pacientes foram avaliados clínica e radiologicamente, segundo protocolo predefinido, com radiografias seriadas e avaliação funcional, conforme o escore funcional de Enneking. RESULTADOS: A idade média do diagnóstico foi de 14A e 4M, sendo o local preferencial de acometimento a epífise distal do fêmur (75%, seguido pela tíbia proximal (16,6% e calcâneo (8,4%. Houve prevalência maior no sexo masculino em relação ao sexo feminino (3:1. Em três casos houve necessidade prévia de biópsia. Durante o seguimento, não evidenciamos recidiva local do tumor e todos os pacientes apresentaram excelente resultado funcional, com escore de Enneking entre 20 e 30, com a técnica cirúrgica empregada. CONCLUSÃO: O tratamento cirúrgico do condroblastoma, com ressecção intralesional, uso de adjuvância, com eletrocauterização e substituição por metilmetacrilato ou enxerto ósseo produz bons resultados.OBJECTIVES: To evaluate the long-term clinical and radiological results from patients who underwent surgical treatment of chondroblastoma, between 2003 and 2009, by the same surgical team, using the same operative

  5. Imaging features of chondroblastoma in tubular and non-tubular bones%管状骨和非管状骨部位软骨母细胞瘤影像特征分析

    Institute of Scientific and Technical Information of China (English)

    胡新杰; 黄满华; 黄劲柏; 李云

    2015-01-01

    目的 探讨管状骨和非管状骨软骨母细胞瘤(chondroblastoma,CB)的影像学特征.方法 回顾性分析经手术病理证实的25例CB的临床及影像学资料,临床资料包括患者的性别、年龄、大小、部位;影像特征包括病灶的边缘、分叶、钙化、皮质膨胀、骨破坏、骨膜反应、软组织成分,水肿及有无继发动脉瘤样骨囊肿.结果 25例患者均行X线检查,病灶呈溶骨型骨质破坏.其中16例位于管状骨的骨骺及骨端,7例病灶边缘清,9例病灶部分边缘清,5例有骨膜反应.另外9例发生于非管状骨,病灶边缘清8例,皮质膨胀8例.CT显示病灶呈圆形、分叶状软组织密度,伴有斑点状、条状或结节状钙化,病灶周边见边界不清的斑片状硬化.MRI显示病灶呈等T1混杂T2信号,病灶周边髓腔内见斑片状长T1长T2,增强扫描明显强化.发病年龄、病灶的边缘、有无皮质膨胀在管状骨和非管状骨之间有统计学差异.结论 CB的影像学表现多具有特征性,发生在非管状骨的病灶年龄偏大,病灶边缘更清,皮质膨胀较管状骨明显.

  6. Clinicopathologic characteristics and histogenesis of chondromyxoid fibroma and chondroblastoma%软骨黏液样纤维瘤和软骨母细胞瘤的临床病理差异与组织发生关系

    Institute of Scientific and Technical Information of China (English)

    黄瑾; 蒋智铭; 张惠箴; 刘亮; 陈杰; 周健华

    2008-01-01

    目的 探讨软骨黏液样纤维瘤(chondromyxoid fibroma,CMF)和软骨母细胞瘤(chondroblastoma,CB)的临床病理差异与组织发生的关系.方法 利用免疫组化EnVision两步法对4例CMF和10例CB行S-100蛋白、Ⅰ~Ⅲ型胶原、MSA,SMA和CD34染色,并对比观察.结果 4例CMF平均年龄为24岁,2例发生于长骨干骺端,2例位于肩胛骨;在4例CMF的小叶间富于细胞区均有数量不等的CB样分化区域;免疫组化标记2例S-100蛋白阳性,各有2例可检测到局灶性表达的Ⅱ型和Ⅰ、Ⅲ型胶原,3例小叶周边区肿瘤细胞表达SMA和MSA.10例CB平均年龄19岁,8例发生于长骨骨骺,1例位于坐骨,1例位于髂骨;免疫组化标记7例S-100蛋白弥漫阳性,2例有局灶性的Ⅱ型胶原表达,3例有多少不等的Ⅰ、Ⅲ型胶原表达,4例部分肿瘤细胞表达SMA和MSA.结论 CMF和CB具有不同的临床病理特征,但CMF中含CB分化的区域,两者均有软骨母细胞和纤维母细胞/肌纤维母细胞的免疫表型,并在细胞外基质中可检测到相似的胶原表达,提示两者在组织发生上有一定联系.

  7. Analysis of the Radiologic Features Relative to Pathology in Chondroblastoma of Bone%软骨母细胞瘤影像学特征及其病理基础

    Institute of Scientific and Technical Information of China (English)

    周建军; 曾蒙苏; 严福华; 丁建国; 王建华; 周康荣

    2009-01-01

    目的 分析软骨母细胞瘤(chondroblastoma,CB)影像表现与病理的关系,以提高对该病的诊断准确性.资料与方法 回顾性分析经手术病理证实的原发性骨骼CB 15例,术前分别行X线平片、CT平扫、MR SET_1WI、T_1WI和SE T_1WI增强扫描.复习影像学图像并与手术病理作对照.结果 15例中,13例位于长管状骨(骨骺12例,干骺端1例),1例位于脊柱椎体及附件,1例位于跟骨.肿瘤直径3.9~7.2 cm,平均5.1 cm.均为溶骨性骨质破坏,无明显膨胀性改变.14例病灶边缘隐约呈结节状突起,可见明显硬化边,1例位于跟骨者无明显硬化边缘.位于管状骨者,病灶多位于骨骺中心骨性关节面下,8例可见钙化,5例无明显钙化;位于椎体和跟骨者,均无明显钙化;1例位于跟骨者,内可见小囊变;1例位于脊柱者可见骨性分隔.5例伴有软组织肿胀.CT示病灶密度略低、等或略高于邻近软组织密度,密度不均匀,CT显示细微钙化更有价值.MR T_1WI为低信号,T_2WI为低、等和高混杂信号,肿瘤边缘可见骨质硬化引起的低信号环.结论 CB不仅位于管状骨,也位于脊柱及跟骨等不规则骨.多数位于长管状骨骨骺中心或骨端骨突部位,肿瘤膨胀改变不明显,瘤内可见弓环状或斑点状钙化,边缘呈分叶结节状,常见明显硬化边,可伴有骨膜反应或邻近渗出,多数肿瘤可以确诊.位于脊柱与跟骨者表现不典型,容易误诊.

  8. Imaging features of chondroblastoma%软骨母细胞瘤影像学表现

    Institute of Scientific and Technical Information of China (English)

    向以四; 姚文轩; 许小伍; 张敏; 刘志远

    2015-01-01

    目的:探讨软骨母细胞瘤影像学的诊断及鉴别诊断价值.方法:对手术病理证实6例软骨母细胞瘤影像学资料进行回顾性分析,总结其影像学表现.结果:胫骨近端1例,股骨远端1例,肱骨近端1例,跟骨2例、肩胛骨1例.影像学表现:膨胀性骨质破坏2例,囊样骨质破坏4例,4例病灶周围(或部分)有硬化边;2例病灶内多发低密度区,5例病灶内有点、条状钙化;2例病灶周围密度增高,边界不清,脂肪间隙模糊;局部皮质消失2例,软组织肿块1例;骨膜反应3例;MRI上T1WI呈低信号,T2WI混杂高/低信号,2例均可见周围软组织及骨髓水肿,增强扫描2例实质部分及间隔强化.结论:软骨母细胞瘤影像学表现具有一定的特征性,其影像学检查方式各有优点,综合X线、CT及MRI多能做出术前正确诊断.

  9. 软骨母细胞瘤研究进展%Research progress of chondroblastoma

    Institute of Scientific and Technical Information of China (English)

    周震涛; 邵增务; 毛唯

    2007-01-01

    软骨母细胞瘤好发部位为四肢长骨的骨骺或骨突,多见于大龄儿童或青少年,男性发病率约为女性的2倍.肿瘤主要由软骨母细胞组成,特征性影像学表现是局限于骨骺处、界限清楚的偏心性溶骨样破坏,并可有钙化和骨膜反应.治疗方法以彻底刮除肿瘤组织后行植骨术为主.软骨母细胞瘤有局部复发及远处转移恶变的报道,是区别于一般良性骨肿瘤的重要特点,控制局部复发及转移恶变已受到关注并成为研究热点.

  10. Imageologic Diagnosis of Chondroblastoma%软骨母细胞瘤的影像诊断

    Institute of Scientific and Technical Information of China (English)

    杨世埙; 王皖; 王武; 朱珠华; 张惠箴

    2004-01-01

    目的:探讨软骨母细胞瘤的影像学表现.材料和方法:回顾性分析34例经病理证实的软骨母细胞瘤的影像学资料,其中34例均有X线平片,1例X线分层,10例CT扫描,7例做了MRI检查.结果:34例中15例X线平片示病灶内有明显的大小不一的钙化,28例X线平片显示病灶边缘均清晰可见.10例行CT扫描的病例显示清晰病灶边界和相应钙化.7例MRI检查病灶为边界清楚,3例T1WI低信号、T2WI中低信号,4例T1WI低信号、T2WI多房高信号,3例可见相应的骨髓水肿,2例显示骨皮质反应,1例显示关节滑膜炎,1例MRI增强的病灶可见病灶部分实质和分房的间隔明显强化.结论:X线平片仍为软骨母细胞瘤的首选检查方法.CT较好地显示骨骼的微细改变.MRI对显示病灶的范围、大小、周围骨骼及软组织的水肿、骨皮质改变和相应的关节改变有明显的优势,并为鉴别诊断提供信息.

  11. Imaging diagnosis of chondroblastoma%成软骨细胞瘤的影像表现

    Institute of Scientific and Technical Information of China (English)

    刘玉珂; 张敏; 王锐; 陈亚玲; 王得玺

    2008-01-01

    成软骨细胞瘤临床较少见,以往其X线及CT表现常有报道,MRI表现则报道较少,而CT及MRI能够提供更多的诊断和鉴别诊断信息。笔者对13例成软骨细胞瘤的影像表现进行回顾性分析,以提高对本病的认识。

  12. 软骨母细胞瘤X线诊断%X-ray diagnosis of chondroblastoma

    Institute of Scientific and Technical Information of China (English)

    胡毓亮

    2004-01-01

    目的:探讨本病的X线征象及X线诊断依据.材料与方法:回顾性分析经手术病理证实的10例软骨母细胞瘤的资料,男6例,女4例.年龄18~35岁.病程0.5~6年.有外伤史5例.主要症状为关节无规律的疼痛,休息后疼痛缓解或消除.术前均作X线平片检查.结果:病变主要累及长管状骨.右侧6例,左侧4例.上肢1例,为肱骨头部.下肢9例,胫骨近端骨骺端4例,股骨大粗隆部3例,股骨颈2例.X线表现:10例均见圆形或椭圆形囊样透亮区,病变区有房隔,病变边缘见硬化环9例,扇状硬化1例.病变区有砂粒样钙化3例,絮状钙化2例.结论:本病好发于骺软骨部位,以长管状骨骺端最常见.X线表现囊状溶骨性破坏区,边缘多有薄层硬化环.病灶内见砂粒样或片絮状钙化是本病诊断依据.

  13. Imageology character of chondroblastoma%成软骨细胞瘤的影像表现

    Institute of Scientific and Technical Information of China (English)

    刘静; 詹玮; 焦俊; 廖欣

    2016-01-01

    目的 探讨成软骨细胞瘤的影像学特征.方法 选取贵州医科大学附属医院2010年1月~2015年12月经病理证实的15例成软骨细胞瘤患者资料,总结其影像学特征.结果 15例中发生在长骨骨端的占13例,其中8例胫骨,4例股骨,1例肱骨,另1例位于髌骨,1例位于距骨.影像表现主要呈类圆形、边界清楚的膨胀性骨质破坏区(X线及CT呈低密度,MRI呈稍长T1、长短混杂T2信号),病灶内部可见钙化灶,边缘有硬化边.结论 仔细分析成软骨细胞瘤的影像学特征,可提高该病的影像诊断水平并及时帮助临床诊断并了解复发、转移及恶变.

  14. Chrondoblastoma of the patella

    Energy Technology Data Exchange (ETDEWEB)

    Moser, R.P. Jr.; Brockmole, D.M.; Vinh, T.N.; Kransdorf, M.J.; Aoki, J.

    1988-09-01

    This study reviews 16 cases of chondroblastoma of the patella which constitute mearly 6% of a large group of chondroblastomas scattered throughout the skeleton. Both radiologic and histologic appearances of chondroblastomas of the patella are indistinguishable from those of chondroblastomas arising in other sites. A reasonable differential diagnosis, including chondromalacia patella, is discussed together with important therapeutic considerations.

  15. 软骨母细胞瘤的X线和CT诊断%X ray and CT diagnosis of chondroblastoma

    Institute of Scientific and Technical Information of China (English)

    陈亚玲; 王军辉; 刘玉珂; 郭会利

    2011-01-01

    @@ 软骨母细胞瘤又称成软骨细胞瘤,是一种少见的骨肿瘤,占原发性骨肿瘤的1.9%,占良性骨肿瘤的3.5%[1].现收集我院2002~2008年的软骨母细胞瘤11例,回顾性分析临床及X线、CT表现,以提高对本病的认识,减少误诊率.

  16. 软骨母细胞瘤的影像诊断价值%Imaging diagnostic value of chondroblastoma

    Institute of Scientific and Technical Information of China (English)

    王桂宁; 张家雄; 霍敏中

    2010-01-01

    目的:分析软骨母细胞瘤的影像学特征及诊断价值.方法:回顾性分析24例经病理证实的软骨母细胞瘤的影像学资料,其中24例均有X线平片,20例CT扫描,12例MRI检查.结果:24例中,X线表现为骨质破坏(22例),病灶周围硬化边(15例),病灶内明显的斑点状及片状钙化(14例).20例CT均显示清晰骨质破坏及硬化边,伴有明显的斑点/片状钙化(18例),骨膜反应(5例)及周围软组织肿胀(9例).12例MRI显示边界清楚的长T1、长短混杂T2信号,5例可见明显的骨髓水肿,3例显示骨膜反应,增强4例强化较明显.结论:软骨母细胞瘤的影像学表现多具有一定的特征性,综合分析X线、CT、MRI表现有助于正确诊断.

  17. 右胫骨远端软骨母细胞瘤一例报告%Right Tibia Distal Chondroblastoma

    Institute of Scientific and Technical Information of China (English)

    阳辉; 秦庆余; 高晓君; 孙洁

    2005-01-01

    青少年软骨母细胞瘤临床较为少见,虽然组织学多为良性肿瘤。但其内在增殖多较为活跃或有侵袭性。所以应积极治疗,日前本院治疗1例疗效良好,现报告如下。

  18. 距骨成软骨细胞瘤1例%Chondroblastoma of talus:a case report

    Institute of Scientific and Technical Information of China (English)

    谢昌林; 张再建

    2011-01-01

    @@ 患者女,18岁.无明显诱因左踝部疼痛半年.体检:左踝关节轻度肿胀,皮温高,距骨压痛明显.X线平片:左距骨内、后见一类圆形骨质破坏区,边缘清晰,部分边缘硬化.内部密度欠均匀,可见高密度钙化影,未见骨膜反应及软组织肿快影.

  19. 成软骨细胞瘤误诊1例%Misdiagnosis of chondroblastoma: a case report

    Institute of Scientific and Technical Information of China (English)

    宋兆亮; 王庆彦

    2002-01-01

    @@ 患者女,27岁.左膝上内侧发现肿块1年.局部肿痛,活动受限,疼痛呈阵发性,与活动无关,夜间疼痛明显.体检:左股内髁处可触及一约6.0cm× 8.0cm质硬肿块,触痛明显,不能推动,表面光滑,皮温不高.实验室检查:血沉及血常规正常.

  20. 软骨母细胞瘤的影像学表现%The Imaging Features of Femur Chondroblastoma

    Institute of Scientific and Technical Information of China (English)

    田野; 陈利军

    2011-01-01

    目的:分析软骨母细胞瘤的影像学特征,提高对该病的影像学诊断.方法:分析2例经手术病理证实为软骨母细胞瘤的患者的影像学资料,总结其X线平片、CT和MRI表现.结果:X线表现:圆形或椭圆形骨质破坏区,偏心性生长.边界清晰,可见硬化边,可见病灶内有点状钙化.CT扫描显示:骨质破坏区边界锐利、硬化,病灶内斑点状或云絮状钙化.MR检查显示:T<,1>WI病灶信号近似于肌肉信号,T<,2>WI上病灶呈等高混杂信号或不均匀高信号,脂肪抑制T<,2>WI示病灶周边见大片状骨髓水肿区;病变临近出现骨膜反应、临近软组织及关节囊肿胀.结论:软骨母细胞瘤影像学表现较有特征性,结合X线平片、CT和MRI能做出正确诊断.

  1. 飞行员软骨母细胞瘤一例%A pilot case of chondroblastoma

    Institute of Scientific and Technical Information of China (English)

    谭清华

    2002-01-01

    @@ 一、临床资料 患者,男性,27岁,运-5飞行员,飞行时间1 000 h.患者发现无痛性左髌骨包块1个月,于2001年7月9日入院.查体:左下肢无畸形,左髌骨下极可见三角形长突,表面无静脉怒张,可扪及包块,约1.0 cm×1.2 cm×2.0 cm,有扣击痛.左髌骨上端内侧可扪及骨性突起,无压痛.左膝关节活动可.X线片示:左膝关节未见异常,左髌骨前下缘骨质结构紊乱,骨质密度不均,向下膨大,边界尚清楚;未发现骨膜反应及软组织肿块影.意见:左髌骨良性骨肿瘤,骨软骨瘤可能性大.2001年7月25日在硬膜外麻醉下,行病灶清除术及植骨术.

  2. 软骨母细胞瘤的影像表现及分析%Chondroblastoma :analysis of imaging manifestations

    Institute of Scientific and Technical Information of China (English)

    吴泽文; 陈焱君; 王洪波; 胡剑

    2010-01-01

    目的:分析总结软骨母细胞瘤的X线、CT及MRI影像学特征.方法:对我院16例经病理证实且行X线、CT和MRI检查的软骨母细胞瘤病人的影像学表现进行回顾性分析.结果:病灶位于胫骨近端6例,股骨远端3例,股骨颈2例,肱骨近端、髌骨、跟骨和髂骨各1例,1例恶性者发生于股骨远端并肺部多发转移.X线表现为骨质破坏(14例),病灶内不规则致密影(5例),病灶周围不同程度骨质硬化(9例).CT上,病灶呈圆形或类圆形低密度影、边缘硬化(15例),病灶内常见点状、片状或条状钙化灶(9例),周围软组织肿胀(7例),骨膜反应(6例).在MRJ上,其表现为在T1WI上呈等、稍低或低信号(11例),在T2WI上呈低、中等或混杂信号(13例),病灶边缘可见低信号环(5例),软组织肿块影(8例).结论:软骨母细胞瘤的影像学表现具有一定的特征性,结合X线平片、CT和MRI能提高对本病的诊断率.

  3. 软骨母细胞瘤的外科治疗%Surgical treatment of the chondroblastoma

    Institute of Scientific and Technical Information of China (English)

    叶招明; 潘伟波; 杨迪生; 李伟栩; 陶惠民

    2005-01-01

    目的探讨软骨母细胞瘤的来源、性质、诊断与治疗方法.方法回顾分析本院具有完整临床资料软骨母细胞瘤32例.结果 32例平均随访78个月,1例股骨近端患者复发经第二次刮除植骨后未见肿瘤复发,1例胫骨近端患者活动时有轻度疼痛,其余效果良好.结论胫骨近端软骨母细胞瘤治疗方法主要为刮除术,植骨或不植骨均有较好的疗效.此瘤虽为良性肿瘤,但有一定的局部复发率,且近年来渐有肺及全身多处骨转移并死亡的报道,故手术时需彻底刮除病灶.

  4. X-Ray analysis of 39 cases with chondroblastoma of long bone%长骨成软骨细胞瘤39例X线分析

    Institute of Scientific and Technical Information of China (English)

    谢元忠; 王大伟; 李长勤

    2002-01-01

    目的分析长骨的成软骨细胞瘤X线平片征象,探讨病灶形态与其周围组织改变的关系.方法对39例发生于长骨的成软骨细胞瘤的X线平片资料进行分析研究,重点分析其骨骼病灶周围的组织改变情况.结果 长骨成软骨细胞瘤骨内病灶形态呈良性表现,同时在病灶周围有23例出现软组织肿胀或/和邻近关节囊肿胀,24例出现骨膜反应.结论成软骨细胞瘤不仅具有良性肿瘤的典型病灶形态,而且在软组织肿胀、骨膜反应及累及邻近关节等方面也具有独特的表现,认识这些征象对本病的诊断与鉴别诊断具有重要作用.

  5. 软骨母细胞瘤的影像诊断和鉴别诊断%Imaging Diagnosis and Differential Diagnosis of Chondroblastoma

    Institute of Scientific and Technical Information of China (English)

    徐福欣; 王静静; 徐高峰; 印春涛

    2009-01-01

    @@ 软骨母细胞瘤又名成软骨细胞瘤、良性成软骨细胞瘤.1942年Jaffe与Lichtenstein发现主要成分为软骨母细胞,遂命名为良性软骨细胞瘤[1].1993年WHO将本瘤分为软骨母细胞瘤和恶性软骨母细胞瘤2类[2].该瘤有侵袭性生长及复发、转移等组织学特性和生物学行为,所以一般命名为软骨母细胞瘤[2~4].

  6. 股骨头软骨母细胞瘤1例%A case report of chondroblastoma of the caput femoris

    Institute of Scientific and Technical Information of China (English)

    吴雪晖; 王序全; 李起鸿; 许建中

    2003-01-01

    软骨母细胞瘤是一种少见的软骨源性肿瘤,约占原发良性骨肿瘤的1%,其好发部位为长管状骨的骨骺部位,多见于股骨、肱骨及胫骨,病变多发生于骨骺即将闭合期间,大多数患者发病年龄小于20岁。本例患者发生于股骨头内,较少见。研究手术治疗效果(并着重介绍手术方法),报告如下。

  7. 软骨母细胞瘤影像学表现及诊断价值%Imaging features of chondroblastoma and its diagnosis value

    Institute of Scientific and Technical Information of China (English)

    张国庆; 郭树农; 卢超

    2009-01-01

    目的 探讨软骨母细胞瘤的影像学特征及诊断价值. 方法分析17例经手术病理或穿刺活检证实的软骨母细胞瘤影像学资料,总结其X线平片、CT和MRI表现. 结果肱骨5例,股骨9例,胫骨3例;病灶呈类圆形分叶状骨质破坏区,部分呈膨胀、偏心性生长:病灶内常有钙化,周围可见硬化带,部分骨皮质断裂,少数有软组织肿块、骨膜反应.MR T1WI以低信号为主,T2WI上信号混杂,增强检查呈不均匀或较均匀强化,骨髓水肿、骨膜反应及软组织肿胀均可强化. 结论软骨母细胞瘤影像学表现较有特征性,结合X线平片、CT和MRI能做出正确诊断.

  8. Imaging features of chondroblastoma (reports of 10 cases)%软骨母细胞瘤影像学表现(附10例报告)

    Institute of Scientific and Technical Information of China (English)

    杨红兵

    2008-01-01

    目的:探讨软骨母细胞瘤的影像学表现.方法:回顾性分析10例经病理证实的软骨母细胞瘤的影像学资料,10例均有X线平片检查,其中7例同时做CT扫描,3例做了MR检查.结果:10例中,8例X线平片显示病灶边缘清晰,可见偏心膨胀性改变,4例病变累及骨骺,4例X线示病灶内有明显的不规则钙化.7例行CT扫描显示病灶边界清晰和斑点、片状钙化.3例MBI检查显示病灶边界清楚,T1低信号、T2WI混杂稍高信号.结论:X线检查是软骨母细胞瘤的首选检查方法,CT和MRI是必要的补充检查方法.软骨母细胞瘤的影像学表现具有一定的特征性,结合临床病史可以提高该病诊断和鉴另4诊断能力.

  9. 软骨母细胞瘤的CT诊断和鉴别诊断%CT diagnosis and differential diagnosis of chondroblastoma

    Institute of Scientific and Technical Information of China (English)

    于爱红; 顾祥; 屈辉; 陈祥述; 白荣杰; 程晓光

    2010-01-01

    目的 探讨软骨母细胞瘤(CB)的CT表现,观察CT对该病的诊断及鉴别诊断价值. 方法 对经手术病理证实的34例CB患者的CT资料进行回顾性分析,分析其病灶位置、形态、密度及增强表现等特征. 结果 28例(82.35%)患者病灶位于长骨;19例(55.88%)病灶边缘可见硬化边;21例(61.76%)病灶内可见点状或沙粒状钙化;全部21例接受增强扫描者均表现为轻中度强化. 结论 CB有较为典型的CT表现;CT对CB的诊断和鉴别诊断具有重要价值.

  10. CLINICAL ANALYSIS ON 50 PATIENTS WITH CHONDROBLASTOMA%软骨母细胞瘤50例临床分析

    Institute of Scientific and Technical Information of China (English)

    庞巨涛; 扈文海; 康肖; 张新虎; 周连军; 孙建华

    2013-01-01

    目的 回顾50例软骨母细胞瘤患者的资料,分析软骨母细胞瘤特点、治疗方法 和疗效.方法 收集1990-2007年经手术病理确诊并有完整随访资料的软骨母细胞瘤共50例.行单纯病灶内刮除4例,刮除植骨31例,刮除骨水泥填充7例,行瘤段切除8例(人工关节置换3例,单纯段切除5例).结果 均随访65.3个月(15~200个月).2例局部复发,经再次手术治疗无复发.复发率为4%.未发现转移者.结论 病灶内刮除术可以取得较好的疗效.

  11. Analysis of CD99 expression in chondroblastoma by immunohistochemistry%CD99在软骨母细胞瘤中的表达及其意义

    Institute of Scientific and Technical Information of China (English)

    螘国铮; 丁敏; 王晓秋; 邢晓皖; 吴红阳

    2004-01-01

    目的探讨CD99在软骨母细胞瘤的表达.方法应用免疫组织化学S-P法,观察12例软骨母细胞瘤的病理形态.结果 12例软骨母细胞瘤中9例CD99阳性,在无基质的软骨母细胞和部分网状基质内软骨母细胞处表达,基质明显区和钙盐沉积处的软骨母细胞和软骨细胞均阴性.S-100蛋白、Vim、NSE弥漫强阳性,多核巨细胞CD68阳性.结论 CD99对软骨母细胞瘤阳性无特异性诊断价值.联合应用CD99、S-100蛋白和Vim等标记,进一步说明软骨母细胞瘤是由胚胎性软骨母细胞发生.

  12. 成人软骨母细胞瘤临床及CT表现%The Clinical and CT Appearance of Chondroblastoma in Adult

    Institute of Scientific and Technical Information of China (English)

    谢兰新; 张桂荣; 韩春庆; 孙英彩

    2003-01-01

    目的:探讨成人软骨母细胞瘤的临床、CT表现及本病的CT诊断价值.材料与方法:9例经手术病理证实的软骨母细胞瘤均行连续CT扫描,扫描层厚5mm,间距5mm.结果:9例中男4例、女5例,年龄18~44岁,平均27.5岁.临床主要症状为疼痛.CT表现:5例呈膨胀性骨质破坏,2例呈侵润性生长,2例病灶较小边缘清晰无膨胀,7例伴有钙化,7例病灶周围有硬化边.结论:CT对成人软骨母细胞瘤的诊断具有重要意义.

  13. Surgical curettement and bone grafting in a case of left patellar chondroblastoma%左髌骨软骨母细胞瘤刮除植骨1例

    Institute of Scientific and Technical Information of China (English)

    陈明; 周玉娟

    2005-01-01

    患者,男,19岁,1年前无明显诱因感左膝部疼痛不适,伸直膝关节时加重。该症状反复发作,活动时加剧,休息后缓解,与天气变化无关。于2003年11月19日到我院就诊.门诊X线片示:左髌骨稍增大,其内呈膨胀性骨质破坏,有大小不等囊状低密度影,伴少许钙化样组织分隔;髌骨骨皮质完整,周边骨质密度稍高,髌股关节无明显改变,周围软组织无肿胀。

  14. 软骨母细胞瘤23例临床分析%The cilinical analysis on 23 cases with chondroblastoma

    Institute of Scientific and Technical Information of China (English)

    杨帆; 许刚

    2012-01-01

    目的:探讨软骨母细胞瘤的诊断特点、治疗方法和临床疗效.方法:对2007年-2011年收治的23例软骨母细胞瘤患者临床资料进行回顾性分析.结果:23例软骨母细胞瘤患者中胫骨上端11例(47.8%),股骨下端8例(34.8%),股骨上端3例(13.0%),肱骨上端1例(4.3%).给予囊内切除20例,边缘或广泛切除3例.平均随访时间为42.6个月,有1例复发,复发者为囊内切除术后,复发率为4.3%.边缘或广泛切除术后无复发,但患者出现严重的功能障碍.结论:软骨母细胞瘤的发生多见于青少年,手术切除治疗预后良好.

  15. Imaging Diagnosis and Comparative Study of Chondroblastoma%软骨母细胞瘤的影像学表现及对比研究

    Institute of Scientific and Technical Information of China (English)

    朱苏元; 李颖端; 宫少兰; 刘吉华

    2007-01-01

    目的 分析对比软骨母细胞瘤的X线、CT及MR影像学特征.方法 分析经病理证实且于2周内行X线、CT和MR检查的22例软骨母细胞瘤病人的影像学表现.2例同时行CT平扫和增强扫描,7例同时行MR平扫和增强扫描.结果 病灶位于胫骨上端11例,股骨下端4例,髌骨2例,肱骨上端、股骨上端、颞骨和下颌骨各1例.1例恶性者发生于髂骨并同时累及骶骨.X线表现为骨质破坏(21),病灶内斑片状、斑点状和(或)条状致密影(5),病灶周围边界不清的斑片状硬化(10).CT上,病灶呈类圆形分叶状(14),内为软组织密度(7),伴有斑片状、斑点状和(或)结节状钙化(15),病灶周围出现边界不清的斑片状硬化(15),病变周围软组织肿胀(18).病灶在T2WI和脂肪预饱和T2WI均呈混杂信号(22),病灶周围髓腔内有边界不清的斑片状长T1长T2信号(20).结论 良性软骨母细胞瘤的影像学表现多具有特征性,X线平片、CT和MRI多数征象相互对应.

  16. Radiological characteristics of periosteal reactions in chondroblastoma%成软骨细胞瘤骨膜反应的影像特点

    Institute of Scientific and Technical Information of China (English)

    谢元忠; 谢丛华

    2008-01-01

    目的 分析成软骨细胞瘤骨膜反应的X线及CT表现特点,探讨其诊断价值.方法 对39例成软骨细胞瘤的X线平片及CT资料进行回顾性分析研究,重点分析其骨膜反应的部位、形态及范围.结果 39例中24例出现骨膜反应,在平片上8例位于干骺端的两侧,CT上见环绕骨皮质周围,较广泛.5例骨膜反应与皮质断裂处有一间隔距离;3例位于皮质断裂处的对侧.5例骨膜反应很广泛,在CT上呈不规则的广泛花边状改变.7例伴有周围软组织肿胀.结论 成软骨细胞瘤骨膜反应广泛,形态多样,与病灶部位及病灶的良性形态不相称;这一征象对本病的诊断与鉴别诊断具有重要价值.

  17. 软骨母细胞瘤的影像学诊断及鉴别诊断%Imaging Diagnosis and Differential Diagnosis of Chondroblastoma

    Institute of Scientific and Technical Information of China (English)

    杨冠英; 陈王坚; 黎家强

    2011-01-01

    目的:探讨软骨母细胞瘤的影像学表现及其特征.材料与方法:搜集资料完整的经病理证实的软骨母细胞瘤10例,回顾性分析软骨母细胞瘤的影像学表现.结果:10例均摄X线平片,7例行CT检查,7例行MRI检查,髂骨2例,胫骨骨骺3例,股骨远端骨骺1例,髌骨2例,肱骨大结节骨骺1例,股骨大转子骨骺1例,1例合并动脉动瘤样骨囊肿,X线平片显示3例有钙化,CT检查5例有钙化灶,7例行MRI检查均提示病灶内有软骨样基质T2WI较高的信号和肿瘤边缘有MRI的T1WI及T2WI上均为低信号的环形硬化边.结论:掌握软骨母细胞瘤的影像学特点,对软骨母细胞瘤的定性诊断及鉴别诊断具有重要意义.

  18. Radiologic Fingdings of Chondroblastoma in Atypical sites%非典型部位成软骨细胞瘤的影像表现

    Institute of Scientific and Technical Information of China (English)

    王矞辉; 李玉清; 丁建平; 王冬梅

    2008-01-01

    目的 探讨非典型部位成软骨细胞瘤的影像表现.资料与方法 回顾分析经病理证实的11例非典型部位的成软骨细胞瘤的影像表现.结果 髌骨6例,肩胛骨2例,腓骨小头、肋骨、头状骨各1例.影像学表现主要为类圆形囊状低密度区,周围可见轻微硬化边;以膨胀性骨质破坏为主,其内有或无分隔,见骨嵴,偶尔见斑点及片状钙化.MRI表现为稍不均匀的长T1、长T2信号.结论 非典型部位的成软骨细胞瘤影像表现具有一定特点.

  19. A case report of rare chondroblastoma of the phalanx%罕见的趾骨软骨母细胞瘤1例

    Institute of Scientific and Technical Information of China (English)

    吴雪晖; 李起鸿

    2002-01-01

    患者,男,15岁,因左足进行性疼痛、肿胀4月于2001年5月22日入院.查体:左足第三跖趾关节及近节趾骨处肿胀,局部皮温高,压痛明显,跖趾关节及趾间关节活动轻度受限, 无感觉及血运障碍.X片示:左足第三趾近节趾骨有一1 cm×1.5cm椭圆形偏心性骨密度降低区,病灶内呈溶骨样破坏,密度不均,向周围呈膨胀样生长,骨皮质变薄,无骨膜反应.入院后于2001年5月24日在硬膜外麻醉下行肿瘤刮除植骨术.

  20. Chondroblastoma with aneurysmal bone cyst: case report%软骨母细胞瘤合并动脉瘤样骨囊肿1例

    Institute of Scientific and Technical Information of China (English)

    张鹏; 李振龙; 赵英杰

    2006-01-01

    患者男,24岁,以“右髋部酸痛半年,摔伤后疼痛2h”为主诉入院,继往半年前出现右股骨大粗隆部酸痛,以活动性为明显,休息可缓解,未就诊治疗,因2h前不慎扭伤后感觉右髋酸痛难忍,行走困难,遂就诊我院。既往体健,否认肺结核及肝炎等传染疾病史,有青霉素过敏史。查体:右髋部未见明显肿胀,

  1. 甲状软骨母细胞瘤1例%A case report of chondroblastoma of the thyroid cartilage

    Institute of Scientific and Technical Information of China (English)

    李全辉; 严得庆; 南娟; 高亚军

    2008-01-01

    患者,女,40岁。因颈前右侧无痛性包块逐渐增大2年,伴声音嘶哑6个月入院。患者于2年前无意中发现颈前右侧一包块,约鸽蛋大小,无疼痛,包块逐渐增大,近半年来明显增大,仍无疼痛。6个月前出现声音嘶哑,梗噎感,后于多家医院就诊,均诊断为甲状腺肿,经中西药治疗,效果不佳。发病前无外伤史。入院查体:一般情况好,颈前皮肤无红肿及破溃,颈部右侧明显肿大,颈软、无抵抗,

  2. 软骨母细胞瘤的临床治疗进展%Advances in Clinical Treatment on Chondroblastoma of Bone

    Institute of Scientific and Technical Information of China (English)

    2016-01-01

    软骨母细胞瘤是一种少见的原发性骨肿瘤,具有恶变倾向,甚至发生远处转移,严重影响患者的肢体功能.传统的治疗方法以病灶刮除联合植骨治疗为主,但术后有一定的局部复发率.随着术中辅助治疗的发展和使用,有效的降低术后复发率,而非手术治疗方案的选择也逐步受到重视.本文综述了软骨母细胞瘤的流行病学、临床表现、病理组织学、影像学表现、治疗现状及预后,有助于系统的认识和了解这种疾病,对于指导临床治疗、改善患者预后具有重要意义.

  3. Case report 373: Diametaphyseal chrondroblastoma of the upper portion of the left femur

    Energy Technology Data Exchange (ETDEWEB)

    Sotelo-Avila, C.; Sundaram, M.; Graviss, E.R.; Kyriakos, M.; Tayob, A.A.

    1986-06-01

    In summary, a case has been presented of a chondroblastoma of the diametaphysis of the upper end of the left femur in an 11-year-old girl. Despite its atypical location, the tumor proved to be a characteristic chondroblastoma on microscopic examination. The literature was reviewed comprehensively and it was noted that 12 examples of chondroblastoma arising outside an epiphysis (or apophysis) were noted. (orig./SHA).

  4. 中颅窝沟通性软骨母细胞瘤1例及文献复习%Chondroblastoma of the temporal bone invading the middle cranial fossa and infratemporal fossa (One case report and literature review

    Institute of Scientific and Technical Information of China (English)

    马杰科; 刘劲松; 吕扬成; 吴宇平; 王光辉; 朱江

    2009-01-01

    目的 报道1例中颅窝沟通性软骨母细胞瘤,结合相关文献对该类肿瘤的诊断和治疗进行复习.方法 分析我科收治1例中颅窝沟通性软骨母细胞瘤的临床特征及治疗方法,并搜索MEDLINE数据库对所有颞骨软骨母细胞瘤相关文献有关治疗方法及术后并发症等进行分析.结果 本例患者肿瘤位于中颅窝,向颅内外沟通性生长,采用颞下颧弓入路手术切除,术后给予残留肿瘤立体定向放疗.随访1年,患者症状改善,无术后并发症.结论 对颅底沟通性软骨母细胞瘤手术为主要治疗方案,对残余肿瘤可采用伽玛刀等综合治疗.

  5. 软骨母细胞瘤的X线及CT诊断(附14例分析)%The imaging diagnosis of chondroblastoma of the X-ray and CT (analysis of 14 cases)

    Institute of Scientific and Technical Information of China (English)

    张永寿; 吴宏

    2011-01-01

    软骨母细胞瘤又称成软骨细胞瘤.属于一种少见的良性骨肿瘤,国内外文献虽有报道[1-3],但因其具有潜在的恶性和术后复发率高的特点,准确的诊断和处理无疑具有重要临床意义.现对我院经过手术及病理证实的14例软骨母细胞瘤的X线及CT的影像学表现进行回顾性分析.

  6. 软骨母细胞瘤临床及CT表现(附18例分析)%The Clinical and CT Appearance of Chondroblastoma (An Analysis of 18 cases)

    Institute of Scientific and Technical Information of China (English)

    孙英彩; 崔建岭; 李石玲; 赵建; 张敏

    2003-01-01

    目的探讨软骨母细胞瘤的临床、CT表现及本病的CT诊断价值.方法 18例经手术病理证实的软骨母细胞瘤均行CT扫描,分析其CT及临床表现.结果 18例中男9例、女9例,年龄11~44岁,平均20.9岁.临床主要症状为疼痛.CT表现:10例呈膨胀性骨质破坏(占55.6%),5例呈浸润性生长,高密度病变1例,13例伴有钙化,13例病灶周围有硬化边.结论 CT对软骨母细胞瘤的诊断具有重要意义.

  7. The imaging diagnosis of malignant chondroblastoma - 3 Case report and review of the litevature%恶性软骨母细胞瘤的影像学诊断(附3例报告及文献复习)

    Institute of Scientific and Technical Information of China (English)

    廖昕; 陈卫国; 吴元魁; 王刚; 牛艳坤

    2006-01-01

    目的:探讨恶性软骨母细胞瘤的影像学诊断及鉴别诊断.方法:报告3例经手术病理证实为恶性软骨母细胞瘤的影像学资料,并结合文献分析良、恶性软骨母细胞瘤的影像学表现特点.结果:本组病例发生于长骨1例,扁骨2例.病灶呈类圆形骨质破坏,与周围分界较清.X线平片显示3例病灶为低密度骨质破坏,2例病灶无明显膨胀,1例轻度膨胀,1例病灶内见清晰钙化影.CT扫描3例病灶均表现为低密度骨质破坏,内有斑片或斑点状钙化.结论:恶性软骨母细胞瘤多表现为类圆形低密度骨质破坏区,病灶内伴有斑片或斑点状钙化.X线平片为软骨母细胞瘤首选检查方法,但CT扫描能较清楚的显示病灶内的微细改变.

  8. 不规则骨成软骨细胞瘤的影像表现%Radiological findings of the chondroblastomas on the atypical sites of the skeleton system

    Institute of Scientific and Technical Information of China (English)

    张鹤; 姚伟武; 杨世勋; 李明华; 程英升; 张惠箴

    2007-01-01

    目的 总结不规则骨成软骨细胞瘤的影像特征.方法 回顾性分析13例少见部位成软骨细胞瘤影像资料,其中男9例,女4例,年龄10~50岁.归纳其在不同影像检查方法下的表现特点.结果 13例病变中,肩胛骨3例、髋臼骨2例、足部跟骨4例、距骨3例、足舟骨1例;X线平片检查13例,均表现为溶骨性病变,低密度10例,混杂密度3例,10例呈膨胀性.CT检查11例,病灶边界不清3例,内部见钙化灶8例,病灶周围见骨质硬化缘10例,病灶内部见间隔4例,3例肿瘤周围见软组织肿块.MR检查5例,T1WI表现为等、低信号,T2WI为不均质高信号,3例可见液-液平面及实体-液平面;1例行增强扫描,肿瘤实体部分呈轻度强化,间隔明显强化.结论 不规则骨成软骨细胞瘤影像学表现不具特征性,但仍具软骨类肿瘤的共性特点,合理运用不同的影像检查方法有助于术前正确诊断.

  9. 15例软骨母细胞瘤的影像学特征及其诊断讨论%The discussion of radiological characteristics and diagnosis of chondroblastoma in 15 cases

    Institute of Scientific and Technical Information of China (English)

    夏华杰; 王国平; 吴仕龙

    2010-01-01

    目的:探讨软骨母细胞瘤的影像学特征.方法:分析15例经手术病理或穿刺活检证实的软骨母细胞瘤影像学资料,总结其X线平片、CT和MRI表现.结果:病变部位股骨7例,胫骨4例,肱骨3例,髂骨1例.病灶形态为分叶状,大部分病灶呈膨胀性生长,病灶内常有钙化,周围可见硬化带.少数有软组织肿块、骨膜反应.MRIT1WI以中低信号为主T2WI上病灶表现为混杂信号,增强后病灶部分实质和分房的间隔明显强化.结论:软骨母细胞瘤影像学表现较有特征性,结合X线平片、CT和MHI能作出正确诊断.

  10. Sneak Curettage Bone Graft Treat Lesions of Distal Femoral Epiphyseal Chondroblastoma%病灶潜行刮除植骨治疗股骨远端骨骺软骨母细胞瘤

    Institute of Scientific and Technical Information of China (English)

    于川东

    2012-01-01

    目的 探讨病灶潜行刮除植骨治疗股骨远端骨骺软骨母细胞瘤的临床疗效.方法 对本院2001 年1 月至2011 年10 月收治的股骨远端骨骺软骨母细胞瘤资料完整的9 例进行回顾性分析.男6 例,女3 例,平均年龄12 岁(6 ~ 7 岁),均行病灶潜行刮除植骨术.结果 本组病例的9 例患者均行不破坏骺板和关节软骨的病灶潜行刮除植骨术,随访时间12 ~ 142 个月,平均随访77.8 个月,无复发病例.结论 病灶潜行刮除植骨术治疗股骨远端骨骺软骨母细胞瘤可以获得满意的临床疗效.

  11. 23例手部内生软骨瘤的临床及影像学分析%Analysis of Clinical and Imaging of 23 Patients with Chondroblastoma Hand Endogenetic Theory

    Institute of Scientific and Technical Information of China (English)

    舒凡

    2015-01-01

    目的总结对手部内生软骨瘤的诊治疗效。方法2008年7月~2014年3月对23例手部内生软骨瘤进行诊治。肿瘤生于掌骨15例,指骨6例,掌骨指骨多发2例。23例26处患指、掌骨有典型X线表现,病理学证实。23例患者均行肿瘤手术刮除加植骨。结果术后随访6个月~6年,平均21个月。22例治愈,X线复查未见复发,证实骨愈合。有2例患者手部伸肌腱发生粘连,其余21例患者手功能正常。1例掌指骨多发内生软骨瘤患者术后11个月X线检查发现环指近节指骨内生软骨瘤复发。继续随访8个月未见瘤体显著变化,未予再次手术。结论手部内生软骨瘤临床表现特征性不明显,结合影像学、病理学特点可明确诊断,彻底手术切除是有效方法。%Objective To improve the accuracy of diagnosis and surgical treatment of enchondromas in the hand . Methods 23 cases with enchondromas in the hand were analyzed retrospectively. These cases were treated in NingBo NO.6 Hospital from July 1996 to December 2004.Among these 23 patients , 15 patients had a lesion located on the palm ,6 patients had a lesion on the finger ,and the other 2 had lesions both on the palm and the finger. Al of the 23 patients had 26 lesions had specific feature on X-ray, proved by pathology. Al of the tumors had been cleared with bone graft. Results The 23 patients were fol owed -up by radiology examination of an average of 21 months after operation. 22 patients were not liable to recure,1 case had lesions both on the palm and the finger were cured on ring finger. The lesions was fol owed-up 8 months , the tumors without operation. Conclusion Enthondromas in the hand hasn't specific feature on clinical presentation , but has specific feature on pathology and radiology examination. In most circumstance , it can be diagnosis definitely . Local cleared with bone graft is an ef ective mothds.

  12. Total maxillary reconstruction using a double-barreled and double skin paddle fibular flap after total maxillectomy.

    Science.gov (United States)

    de la Parra, Miguel; Sanchez, Gerardo; Lopez, Jaime; Perez, Adrian; Naal, Norberto

    2013-11-01

    Chondroblastomas are rare entities accounting for approximately 1% of all primary bone tumors. We describe a case of a 7-year-old girl with a giant chondroblastoma of the maxilla, treated with bilateral class III maxillectomy and reconstruction with a double-barreled and double skin paddle fibular free flap. We show evidence of an excellent aesthetic outcome at 6 months' follow up with no evidence of tumor recurrence.

  13. Magnetic resonance imaging appearance at 1. 5 tesla of cartilaginous tumors involving the epiphysis

    Energy Technology Data Exchange (ETDEWEB)

    Fobben, E.S.; Dalinka, M.K.; Schiebler, M.L.; Burk, D.L.; Kressel, H.Y.; Fallon, M.D.; Schmidt, R.G.

    1987-11-01

    Three cases of lytic, calcified epiphyseal lesions with plain film and computed tomography features suggestive of chondroblastoma were imaged by magnetic resonance imaging. Histopathologic correlation was obtained in each case. Two cases of chondroblastoma showed low signal intensity on both short (TR600/TE20ms) and long (TR2500/TE80ms) spin echo (SE) images. The third case, a clear cell chondrosarcoma, demonstrated increased signal intensity on moderately T2 weighted (TR2500/TE40ms) images. These findings suggest that magnetic resonance imaging may be helpful in distinguishing these lesions. (orig.)

  14. A RARE CARTILAGINOUS TUMOR OF THE TALUS

    Directory of Open Access Journals (Sweden)

    Alok Sobhan

    2014-06-01

    Full Text Available The present report describes an unusual and rare tumor originating from the talus. A 21 years old female presented with a swelling over the right ankle 4x3.5cms in size for one year. The lesion was osteolytic with surrounded peripheral rim of bone sclerosis. Subsequent pathological study confirmed the case as chondroblastoma. The lesion was curettaged and the resultant defect was filled by autogenous bone graft. Such tumors are as chondroblastoma usually originate from epiphyseal and apophyeal regions of long bones. Thorough clinical, radiological and histological assessment is required for appropriate management.

  15. Eosinophilic granuloma of the capital femoral epiphysis.

    Science.gov (United States)

    Goto, Takahiro; Nemoto, Tetsuo; Ogura, Koichi; Imanishi, Jungo; Hozumi, Takahiro; Funata, Nobuaki

    2011-05-01

    Eosinophilic granuloma occurs almost exclusively in the diaphysis or metaphysis, when tubular bones are affected. The investigators present an extremely rare case of eosinophilic granuloma arising at the epiphysis of the femoral head in an 8-year-old boy. Plain radiographs and computed tomography showed a well-circumscribed radiolucent lesion, suggesting chondroblastoma or Brodie's abscess. However, the findings on magnetic resonance images were different from typical features of chondroblastoma or Brodie's abscess. The lesion was curetted. Histological diagnosis was eosinophilic granuloma. Differential diagnoses of a radiolucent lesion at the epiphysis in a child should include, though quite rare, eosinophilic granuloma.

  16. Effect of surgical treatment of chondroblastoma in children and adolescents on growth and development of epiphyseal plate in long bones%儿童及青少年长骨软骨母细胞瘤手术对骺板生长发育的影响

    Institute of Scientific and Technical Information of China (English)

    张开伟; 段宏; 屠重棋; 项舟; 陈久毅

    2014-01-01

    目的 探讨儿童及青少年长骨骨端软骨母细胞瘤手术治疗对后期骺板生长发育的影响.方法 对12例儿童及青少年长骨骨端软骨母细胞病患者施行病灶刮除(骺板开孔)并植骨术,术后测量患肢的短缩长度,并分析术后骺板缺损大小与肢体长度的关系.结果 12例病例均获得随访,术后患肢的长度较健侧短缩3~14mm,平均为(5.00±2.13)mm;10例无术后骺板缺损及轻、中度骺板缺损病例的患肢短缩长度均小于10mm,2例重度骺板缺损患者的患肢短缩长度不超过15mm.术后骺板缺损的面积与肢体短缩长度之间有正相关关系(P <0.05,r=0.998),全部病例的ISOLS功能评分平均为28.2分(94%),均未出现局部复发及远处转移,3例发生部分植骨吸收,余病例的植骨融合良好.结论 儿童及青少年长骨软骨母细胞瘤,采用骨开窗并骺板开小孔的病灶刮除、灭活并植骨术,在获得较满意的肿瘤控制的同时,也较易保证<10%的骺板缺损面积,对骺板的生长发育无明显影响.

  17. Epiphyseal osteoblastoma-like osteosarcoma

    Energy Technology Data Exchange (ETDEWEB)

    Bonar, S.F. [Douglass Hanly Moir Pathology, 95 Epping Road, North Ryde, NSW 2113 (Australia); McCarthy, S.; Stalley, P.; Schatz, J.; Soper, J.; Scolyer, R. [Departments of Pathology, Radiology and Orthopaedic Surgery, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050 (Australia); Barrett, I. [Department of Orthopaedic Surgery, The Children' s Hospital, Westmead, NSW 2145 (Australia)

    2004-01-01

    Osteoblastoma-like osteosarcoma is a rare variant of osteosarcoma occurring in this instance in a highly unusual location: the lateral femoral condyle of a 13-year-old girl. The radiological features were non-aggressive and, although slightly unusual, were most suggestive of chondroblastoma. (orig.)

  18. Successful resection of osteosarcoma pulmonary metastasis extending into left side of heart under cardiopulmonary bypass: a case report

    Institute of Scientific and Technical Information of China (English)

    柴(王莹); 沈钢

    2002-01-01

    @@ Cancerous thrombi of metastatic tumors rarely extend into the cardiac cavity, but such cases usually contraindicate surgery. Here, we report a patient in whom osteosarcoma pulmonary metastasis extended into the left side of the heart, which had metastasized to the left lung after surgery of the chondroblastoma of the left knee, was successfully excised in bloc under CPB.

  19. Primary bone tumours in infants

    Energy Technology Data Exchange (ETDEWEB)

    Kozlowski, K.; Beluffi, G.; Cohen, D.H.; Padovani, J.; Tamaela, L.; Azouz, M.; Bale, P.; Martin, H.C.; Nayanar, V.V.; Arico, M.

    1985-09-01

    Ten cases of primary bone tumours in infants (1 osteosarcoma, 3 Ewing's sarcoma, 1 chondroblastoma and 5 angiomastosis) are reported. All cases of angiomatosis showed characteristic radiographic findings. In all the other tumours the X-ray appearances were different from those usually seen in older children and adolescents. In the auhtors' opinion the precise diagnosis of malignant bone tumours in infancy is very difficult as no characteristic X-ray features are present in this age period.

  20. Clear cell chondrosarcoma

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, R.; David, R.; Cierney, G. III

    1985-01-01

    The clinical, radiologic, and histopathologic features of three cases of clear cell chondrosarcoma are described. On radiographs, this rather benign-appearing tumor resembles a chondroblastoma when it occurs at the end of a long bone, and may occasionally show a calcified matrix. However, it has distinctive tumor cells with a centrally placed vesicular nucleus surrounded by clear cytoplasm. The lesion has a low-grade malignancy and is amenable to en bloc surgical resection, which results in a much better prognosis than that of conventional chondrosarcoma.

  1. Primary vertebral tumours in children

    Energy Technology Data Exchange (ETDEWEB)

    Kozlowski, K.; Beluffi, G.; Masel, J.; Diard, F.; Ferrari-Ciboldi, F.; Le Dosseur, P.; Labatut, J.

    1984-03-01

    20 cases of primary benign and malignant bone tumours in children were reported. The most common tumours were Ewing's sarcoma, aneurismal bone cyst, benign osteoblastoma and osteoid osteoma. Some rare primary bone tumours in children (osteochondroma, chondroblastoma 6F, primary lymphoma of bone and neurofibromatosis with unusual cervical spinal changes) were also reported. The authors believe that radiographic findings together with clinical history and clinical examination may yield a high percentage of accurate diagnoses. Although microscopy is essential in the final diagnosis, the microscopic report should be also accepted with caution.

  2. Solitary lucent epiphyseal lesions in children

    Energy Technology Data Exchange (ETDEWEB)

    Gardner, D.J.; Azouz, E.M.

    1988-10-01

    We evaluated retrospectively the varying radiographic appearances of 15 solitary lucent epiphyseal lesions occurring in children. Imaging modalities used included plain films, conventional tomography, nuclear scintigraphy, and computed tomography. 40% of the lesions (6) were due to osteomyelitis. The remaining lesions included tuberculosis (1), foreign body granuloma (1), chondroblastoma (2), chondromyoxid fibroma (1), enchondroma (1), osteoid osteoma (2), and eosinophilic granuloma (1). Although the radiographic appearances of such lesions may be particularly characteristic, pathologic correlation is frequently necessary. The high incidence of osteomyelitis in our cases emphasizes its importance as a cause for a lucent epiphyseal lesion.

  3. Benign and malignant cartilage tumors of bone and joint: their anatomic and theoretical basis with an emphasis on radiology, pathology and clinical biology. Pt. 1. The intramedullary cartilage tumors

    Energy Technology Data Exchange (ETDEWEB)

    Brien, E.W. [Orthopaedic Oncology Service, Orthopaedic Hospital, Los Angeles, CA (United States)]|[Musculoskeletal Tumor Service, Orthopaedic Hospital, Los Angeles, CA (United States); Mirra, J.M. [Orthopaedic Oncology Service, Orthopaedic Hospital, Los Angeles, CA (United States); Kerr, R. [Orthopaedic Oncology Service, Orthopaedic Hospital, Los Angeles, CA (United States)

    1997-06-01

    We reviewed 845 cases of benign and 356 cases of malignant cartilaginous tumors from a total of 3067 primary bone tumors in our database. Benign cartilaginous lesions are unique because the epiphyseal plate has been implicated in the etiology of osteochondroma, enchondroma (single or multiple), periosteal chondromas and chondroblastoma. In the first part of this paper, we will review important clinical, radiologic and histologic features of intramedullary cartilaginous lesions in an attempt to support theories related to anatomic considerations and pathogenesis. (orig.). With 44 figs., 2 tabs.

  4. Case report 390: Tuberculous pseudotumor of the proximal end of the right tibia without obvious synovial involvement

    Energy Technology Data Exchange (ETDEWEB)

    Abdelwahab, I.F.; Present, D.A.; Klein, M.J.

    1986-11-01

    A case of osseous tuberculosis has been presented in a young black man who was known to be an addict to cocaine. An osteolytic lesion involved the proximal end of the tibia, being eccentric and subarticular in location. The knee joint spaces were intact, suggesting that no obvious involvement of the cartilages was present. Thus, neoplastic lesions such as chondroblastoma and giant cell tumor were considered in the differential diagnosis of the lesion which appeared to be benign radiologically. The lesion proved to be tuberculous in nature, with intact knee joint cartilages. A diagnosis of tuberculous 'pseudotumor' might be used aptly. (orig./SHA).

  5. Primary tumors of the patella. A review of 42 cases

    Energy Technology Data Exchange (ETDEWEB)

    Kransdorf, M.J. (Walter Reed Army Medical Center, Washington, DC (USA). Dept. of Radiology; University of the Health Sciences, Bethesda, MD (USA). Dept. of Radiology and Nuclear Medicine); Moser, R.P. Jr. (Armed Forces Inst. of Pathology, Washington, DC (USA). Dept. of Radiologic Pathology; University of the Health Sciences, Bethesda, MD (USA). Dept. of Radiology and Nuclear Medicine); Vinh, T.N. (Armed Forces Inst. of Pathology, Washington, DC (USA). Dept. of Orthopaedic Surgery); Aoki, J. (Armed Forces Inst. of Pathology, Washington, DC (USA). Dept. of Radiologic Pathology); Callaghan, J.J. (Duke Univ., Durham, NC (USA). Dept. of Orthopaedic Surgery)

    1989-08-01

    This study reports 42 cases of histologically proven and radiographically correlated primary patellar tumors. Despite diverse histologic diagnoses, the radiographic appearanaces of benign as opposed to malignant patellar neoplasms are essentially indistinguishable. Although the literature suggests that giant cell tumor is the most frequent benign tumor of the patella, the most common benign neoplasm in this series is chondroblastoma (16 cases). Only four primary malignant lesions were encountered, three cases of lymphoma and one case of hemangioendothelioma. Since 38 (90%) of the 42 cases were benign, a benign etiology should be strongly favored, notwithstanding the radiographic appearance, whenever a primary patellar tumor is encountered. (orig.).

  6. Chondrosarcoma of the Proximal Phalanx of the Fourth Digit: A Rare Location

    Directory of Open Access Journals (Sweden)

    Thivi Vasilakaki

    2012-10-01

    Full Text Available Introduction: Cartilaginous tumors involving the small bones of the hands and feet are usually benign such as enchondroma, chondromyxoid fibroma and chondroblastoma. The small bones of the hands and feet are rarely involved by primary chondrosarcoma. Proximal phalanges are the most common sites in the hands, but the fourth digit is the least common site. Case Presentation: We report a case of a 76-year-old Greek female who presented to our hospital with a painful swollen mass measuring 4.5 × 2.6 cm on the fourth digit of the left hand. The radiograph showed a destructive, permeative lytic tumor of the proximal phalanx with extension into soft tissue. The patient underwent curettage, and the microscopic examination of the specimen revealed grade 2 chondrosarcoma. Conclusion: Cartilaginous tumors involving the small bones of the hands and feet are usually benign such as enchondroma, chondromyxoid fibroma and chondroblastoma. Primary chondrosarcoma is the third most common malignancy of bone after myeloma and osteosarcoma, but the small bones of the hands and feet are very rarely involved by chondrosarcoma (1% of all chondrosarcoma. However, in these cases differentiation between a benign lesion and chondrosarcoma may be difficult. Occasionally chondrosarcoma of the hands and feet is associated with multiple recurrences or distal metastasis.

  7. Follow-up study of cartilaginous bone tumors.

    Directory of Open Access Journals (Sweden)

    Suzuki,Atsushi

    1986-06-01

    Full Text Available A series of clinical and pathological studies were performed on 74 cartilaginous bone tumors including osteochondromas, multiple cartilaginous exostoses, chondromas, chondromatoses, benign chondroblastomas and chondrosarcomas. Resection was adequate for the osteochondromas, and no recurrence was observed. Out of 14 multiple cartilaginous exostoses, three, all in flat bones showed malignant change. The predominant sites of chondroma were the finger and toe bones, and curettage and bone graft was adequate treatment. Neither recurrence nor malignant change was observed. Two cases of chondromatosis, one of Ollier's disease and one of Maffucci's syndrome, were included in our series. Leg length discrepancy and pathologic fracture were common problems in chondromatosis. Moreover, malignant change was suspected in a hemangioma of the Maffucci's syndrome patient. Benign chondroblastoma was treated by curettage and bone graft, with no recurrence. In our series, 4 primary and 3 secondary chondrosarcomas were observed. Metastasis was seen in only one case. Because of the discrepancy between the biological behavior and histological findings of cartilaginous bone tumors, the malignancy of tumors should be evaluated by clinical signs and symptoms as well as by histological findings.

  8. Imaging tumors of the patella

    Energy Technology Data Exchange (ETDEWEB)

    Casadei, R., E-mail: roberto.casadei@ior.it [Department of Orthopaedic Oncology, Istituto Ortopedico Rizzoli, Bologna (Italy); Kreshak, J., E-mail: j.kreshak@yahoo.com [Department of Orthopaedic Oncology, Istituto Ortopedico Rizzoli, Bologna (Italy); Department of Pathology, Istituto Ortopedico Rizzoli, Bologna (Italy); Rinaldi, R. [Department of Radiology, Istituto Ortopedico Rizzoli, Bologna (Italy); Rimondi, E., E-mail: eugenio.rimondi@ior.it [Department of Radiology, Istituto Ortopedico Rizzoli, Bologna (Italy); Bianchi, G., E-mail: giuseppe.bianchi@ior.it [Department of Orthopaedic Oncology, Istituto Ortopedico Rizzoli, Bologna (Italy); Alberghini, M., E-mail: marco.alberghini@ior.it [Department of Pathology, Istituto Ortopedico Rizzoli, Bologna (Italy); Ruggieri, P. [Department of Orthopaedic Oncology, Istituto Ortopedico Rizzoli, Bologna (Italy); Vanel, D., E-mail: daniel.vanel@ior.it [Department of Radiology, Istituto Ortopedico Rizzoli, Bologna (Italy); Department of Pathology, Istituto Ortopedico Rizzoli, Bologna (Italy)

    2013-12-01

    Background: Patellar tumors are rare; only a few series have been described in the literature and radiographic diagnosis can be challenging. We reviewed all patellar tumors at one institution and reviewed the literature. Materials and methods: In an evaluation of the database at one institution from 1916 to 2009, 23,000 bone tumors were found. Of these, 41 involved the patella. All had imaging studies and microscopic diagnostic confirmation. All medical records, imaging studies, and pathology were reviewed. Results: There were 15 females and 26 males, ranging from 8 to 68 years old (average 30). There were 30 benign tumors; eight giant cell tumors, eight chondroblastomas, seven osteoid osteomas, two aneurysmal bone cysts, two ganglions, one each of chondroma, exostosis, and hemangioma. There were 11 malignant tumors: five hemangioendotheliomas, three metastases, one lymphoma, one plasmacytoma, and one angiosarcoma. Conclusion: Patellar tumors are rare and usually benign. As the patella is an apophysis, the most frequent lesions are giant cell tumor in the adult and chondroblastoma in children. Osteoid osteomas were frequent in our series and easily diagnosed. Metastases are the most frequent malignant diagnoses in the literature; in our series malignant vascular tumors were more common. These lesions are often easily analyzed on radiographs. CT and MR define better the cortex, soft tissue extension, and fluid levels. This study presents the imaging patterns of the more common patellar tumors in order to help the radiologist when confronted with a lesion in this location.

  9. Bone marrow oedema associated with benign and malignant bone tumours

    Energy Technology Data Exchange (ETDEWEB)

    James, S.L.J. [Department of Radiology, Royal Orthopaedic Hospital, Birmingham, B31 2AP (United Kingdom)], E-mail: steven.james@roh.nhs.uk; Panicek, D.M. [Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021 (United States); Davies, A.M. [Department of Radiology, Royal Orthopaedic Hospital, Birmingham, B31 2AP (United Kingdom)

    2008-07-15

    Bone marrow oedema is associated with a wide variety of pathological processes including both benign and malignant bone tumours. This imaging finding in relation to intraosseous tumours can aid in providing a more focused differential diagnosis. In this review, we will discuss the MR imaging of bone marrow oedema surrounding intraosseous neoplasms. The different pulse sequences used in differentiating underlying tumour from surrounding oedema are discussed along with the role of dynamic contrast enhanced MRI. Benign lesions commonly associated with bone marrow oedema include osteoid osteoma, osteoblastoma, chondroblastoma and Langerhan's cell histiocytosis. Metastases and malignant primary bone tumours such as osteosarcoma, Ewing's sarcoma and chondrosarcoma may also be surrounded by bone marrow oedema. The imaging findings of these conditions are reviewed and illustrated. Finally, the importance of bone marrow oedema in assessment of post chemotherapeutic response is addressed.

  10. An intraosseous lipoma of the calcaneus: a case report.

    Science.gov (United States)

    Pappas, Alexander J; Haffner, Kyle E; Mendicino, Samuel S

    2014-01-01

    Intraosseous lipomas are one of the rarest bone tumors found in the body. The incidence has been reported to be intraosseous lipoma in the calcaneus include plantar fasciitis, retrocalcaneal bursitis, gout, stress fracture, unicameral bone cyst, aneurysmal bone cyst, osteoblastoma, enchondroma, chondromyxoid fibroma, nonossifying fibroma, giant cell tumor, chondroblastoma, fibrous dysplasia, and chondrosarcoma. It has been reported that 60% to 70% of patients with an intraosseous lipoma present with symptoms. This article describes a case of a pathologic fracture secondary to a large intraosseous lipoma, the surgical treatments, and the subsequent resolution of symptoms. The purpose of our report was 3-fold: (1) to increase awareness of intraosseous lipomas and their potential to cause pathologic fractures in the calcaneus; (2) to suggest a possible treatment protocol for intraosseous lipomas in the calcaneus; and (3) to describe a rare case of an intraosseous lipoma of the calcaneus not located exclusively in the neutral triangle.

  11. [Clinical perspectives of the study of RANK/RANKL/OPG system components in primary and metastatic bone tumor].

    Science.gov (United States)

    Kushlinskiĭ, N E; Timofeev, Iu S; Gershteĭn, E S; Solov'ev, Iu N

    2014-01-01

    Disbalance of bone homeostasis, associated with malfunctioning of RANK/RANKL/OPG system underlies the oncological processes such as the destruction of bone, metastasis development, tumor progression. Pathological activity of system was described in such conditions, as breast cancer, prostate cancer, multiple myeloma, squamous cell carcinoma, Hodgkin's disease, and also metastasis in bones from lung cancer and other malignant diseases. In the literature, there is evidence of involvement of RANK/RANKL/OPG system in the pathogenesis of bone tumors (osteosarcoma, giant cell tumor of bone, chondroblastoma). Experimental data show that RANKL inhibitors can play a role in reducing tumor-induced lesions of bone in multiple myeloma, breast cancer, prostate cancer and lung cancer. Also this review presents data from clinical studies of the drug efficacy targeted on RANK/RANKL/OPG system and results of authors' study of the levels of this system's components and proinflammatory cytokines in blood serum of primary bone sarcoma patients.

  12. Extraskeletal Osteosarcoma of Penis: A Case Report

    Institute of Scientific and Technical Information of China (English)

    Chuan-zhen Wu; Cheng-mei Li; Song Han; Shuang Wu

    2012-01-01

    Extraskeletal osteosarcoma (EOS) is rare and commonly arises in the retroperitoneum,limbs,head and neck.There is no significant difference between EOS and other malignant tumors in soft tissue.Localized pain and swelling are the common presenting symptoms.Clinical diagnosis of EOS is difficult,imaging techniques may be helpful and careful,and the histopathological analysis is necessary.The common histological variants of EOS include:osteoblastoma,chondroblastoma,and fibroblastoma,and other unusual subtypes were reported occasionally.It should be distinguished with myositis ossificans,malignant mesenchymoma,giant cell tumor and parosteal osteosarcoma.We present an EOS arising in the penis.The primary site and histological category of the tumor were extremely rare.We hope the case will be helpful to the recognition of clinical signs,iconography and histopathology of EOS.

  13. Giant cell reparative granuloma of the hallux following enchondroma

    Science.gov (United States)

    Kamoun, Khaled; Sellami, Tarak; Jlailia, Zied; Abid, Layla; Jenzri, Mourad; Bouaziz, Mouna; Zouar, Omar

    2015-01-01

    Giant cell reparative granuloma (GCRG) is a rare, benign intra osseous lytic lesion occurring especially in gnathis bone but also seen in feet and hands. It has similar clinical and radiological presentations than giant cell tumor, chondroblastoma, aneurysmal bone cyst, and hyperparathyroidism brown tumors but with specific histological findings We report a case of a GCRG of hallux phalanx in 18 years old patient appearing many years after enchondroma curettage and grafting. Radiographs showed a multiloculated osteolytic lesions involving whole phalanx with cortical thinning and without fluid-fluid levels in CT view. Expected to be an enchondroma recurrence, second biopsy confirmed diagnosis of GCRG with specific histological findings. Although if aetiopathogeny remains unknown, GCRG is reported to be a local non neoplasic reaction to an intraosseous hemorrhage. Our exceptional case claims that this tumor can appear in reaction to cellular disturbance primary or secondary. PMID:26985281

  14. 两种少见软骨性肿瘤外科病理的诊断要点与鉴别诊断

    Institute of Scientific and Technical Information of China (English)

    陈天水

    1999-01-01

    @@ 1 软骨母细胞瘤(chondroblastoma) 1.1 诊断要点 1.1.1 性别年龄最常见于10~20岁.男多于女. 1.1.2 辅助检查 X线下,大多为一类圆形模糊的斑点状阴影,边缘由一薄的硬化性骨质所包绕.X线下钙化的表现,象一些作者所描述的为一种绒毛棉花状.骨周反应不常见.由于它有明显的骨质破坏,因此X线下可误诊为一种恶性肿瘤.

  15. 软骨母细胞瘤的CT及低场MRI诊断价值(5例报告及文献复习)

    Institute of Scientific and Technical Information of China (English)

    胡智斌

    2011-01-01

    @@ 软骨母细胞瘤(chondroblastoma,CB)又称成软骨细胞瘤,是一种少见的软骨源性肿瘤,约占原发骨肿瘤的1%[1].CB具有特殊的生物学和病理学特征,术前正确诊断有助于制定手术方案和改善患者预后.现回顾性分析我院2003年8月~2010年11月经手术病理证实的5例CB的CT和低场MRI资料,并结合文献对其诊断和鉴别诊断价值作出评价,以期提高诊断水平.

  16. CT evaluation of primary epiphyseal bone abscesses

    Energy Technology Data Exchange (ETDEWEB)

    Azouz, E.M. (Dept. of Radiology, McGill Univ., Montreal Children' s Hospital, PQ (Canada)); Greenspan, A. (Dept. of Radiology, California Univ., Davis School of Medicine, Sacramento, CA (United States)); Marton, D. (Dept. of Radiology, Montreal Univ., Hopital Ste Justine, PQ (Canada))

    1993-01-01

    We reviewed the clinical, radiographic, and computed tomographic (CT) findings in eight children with a histologically proven diagnosis of epiphyseal or apophyseal osteomyelitis. In all cases the femur was involved: in five the osteomyelitis was localized in the femoral condyle, in two it was in the greater trochanter, and in one it was in the femoral head epiphysis. In four of the six cases of epiphyseal involvement there was associated joint effusion or septic arthritis. CT examination may demonstrate a serpentine tract, a sequestrum, cortical destruction or adjacent soft tissue swelling and can differentiate osteomyelitis from other epiphyseal lucent lesions, particularly chondroblastoma and osteoid osteoma. Early diagnosis helps avoid delays in initiating antibiotic or surgical treatment caused by the unusual (epiphyseal or apophyseal) location of the bone abscess. (orig./GD)

  17. Clival Lesion incidentally discovered on cone-beam computed tomography: A case report and review of the literature

    Energy Technology Data Exchange (ETDEWEB)

    Jadhav, Aniket B.; Tadinada, Aditya; Rengasamy, Kandasamy; Lurie, Alan G. [Dept. of Oral and Maxillofacial Radiology, University of Connecticut School of Dental Medicine, Farmington (United States); Douglas, Fellows [Division of Diagnostic Sciences and Therapeutics, University of Connecticut School of Medicine, Farmington (United States)

    2014-06-15

    An osteolytic lesion with a small central area of mineralization and sclerotic borders was discovered incidentally in the clivus on the cone-beam computed tomography (CBCT) of a 27-year-old male patient. This benign appearance indicated a primary differential diagnosis of non-aggressive lesions such as fibro-osseous lesions and arrested pneumatization. Further, on magnetic resonance imaging (MRI), the lesion showed a homogenously low T1 signal intensity with mild internal enhancement after post-gadolinium and a heterogeneous T2 signal intensity. These signal characteristics might be attributed to the fibrous tissues, chondroid matrix, calcific material, or cystic component of the lesion; thus, chondroblastoma and chondromyxoid fibroma were added to the differential diagnosis. Although this report was limited by the lack of final diagnosis and the patient lost to follow-up, the incidental skull base finding would be important for interpreting the entire volume of CBCT by a qualified oral and maxillofacial radiologist.

  18. Chondromyxoid fibroma of the acromium with soft tissue extension

    Energy Technology Data Exchange (ETDEWEB)

    Macdonald, D. [Departments of Anatomic and Clinical Pathology, Sunnybrook and Women' s College Health Sciences Centre, Orthopedic and Arthritic Institute, Toronto, Ontario (Canada); University of Toronto, Toronto, Ontario (Canada); Fornasier, V. [Department of Anatomical Pathology and Cytology, St. Michael' s Hospital, Wellesley-Central Site, Toronto, Ontario (Canada); Holtby, R. [Department of Surgery, Sunnybrook and Women' s College Health Sciences Centre, Orthopedic and Arthritic Institute, Toronto, Ontario (Canada)

    2000-03-30

    Chondromyxoid fibroma is an unusual, benign tumor of cartilaginous origin and represents less than 1% of all primary bone tumors. It usually involves the long bones around the knee joint or the flat bones of the pelvis or ribs. Soft tissue extension is also thought to be rare in these lesions. They are usually eccentrically located in the metaphyses of the long bones and centrally in the flat bones. The radiographic appearances are characteristically those of a single, lytic lesion with lobulated margins, septations, cortical expansion and a sclerotic rim. Histologically, they display a lobulated pattern with spindle-shaped cells lying within a myxoid matrix with areas of hyaline cartilage. The differential diagnosis includes giant cell tumor, chondroblastoma or enchondroma as well as chondrosarcoma. The rarity of these lesions may render the diagnosis difficult to make, especially when the lesion involves an unusual site such as the acromium. (orig.)

  19. Sliding flap tracheoplasty.

    Science.gov (United States)

    Gates, G A; Tucker, J A

    1989-12-01

    The optimal method for surgical management of subglottic stenosis is based upon careful assessment of the location, caliber, length, and maturity of the stenotic segment, as well as associated conditions. For patients with a mature stenosis of short length, excision of the anterior arch of the cricoid and first ring and immediate reconstruction by means of a sliding flap of the next two to three rings of trachea offer a one-stage definitive treatment without the need for grafting. We report four cases of subglottic stenosis and one case of cricoid chondroblastoma in which reconstruction of the airway was successful and prompt. For carefully selected cases, sliding flap tracheoplasty may be a useful alternative to procedures in which the airway is expanded by means of grafting.

  20. Tumour and tumour-like lesions of the patella - a multicentre experience

    Energy Technology Data Exchange (ETDEWEB)

    Singh, J.; James, S.L.; Davies, A.M. [The Royal Orthopaedic Hospital, Department of Radiology, Birmingham (United Kingdom); Kroon, H.M. [Leiden University Medical Centre, Department of Radiology, C-2-S, P. O Box 9600, Leiden (Netherlands); Woertler, K. [Technische Universitaet Muenchen, Department of Radiology, Munich (Germany); Anderson, S.E. [Knochentumor- Referenzzentrum der Schweizerischen Gesellschaft fuer Pathologie, Basel (Switzerland)

    2009-03-15

    Fifty-nine cases of lesions presenting in the patella were identified after review of the databases of four European bone tumour registries. Of the 59 cases, 46% were non neoplastic, 39% were benign and 15% were malignant. The commonest benign neoplasm was giant cell tumour (GCT) (11 cases). Younger patients were more likely to have a benign neoplasm. Lesions in patients less than 40 years of age included giant cell tumour, chondroblastoma, aneurysmal bone cyst (ABC), osteomyelitis, osteoid osteoma and solitary bone cyst. In patients older than 40 years, the following were common lesions: intra-osseous gout, metastasis and intra-osseous ganglion. Expansion of the patella with thinning of cortex was seen more commonly in GCT and brown tumour in hyperparathyroidism. There was associated soft tissue extension in gout and malignant lesions. (orig.)

  1. Arthroscopic guided biopsy and radiofrequency thermoablation of a benign neoplasm of the tibial spines area: a treatment option

    Directory of Open Access Journals (Sweden)

    Zoccali Carmine

    2012-04-01

    Full Text Available Abstract Background Lesions located in the area of the tibial spines are rare. In most cases, treatment follows histological diagnosis, but when imaging and clinical data are considered to be "very" characteristic for benign lesions, such as chondroblastoma or osteoid osteoma, treatment may be performed without biopsy. Traditional curettage requires opening the joint, which presents a high risk of contamination of the joint itself and surrounding structures, such as the popliteal area, with possible contamination of the neurovascular bundle when performing curettage with the posterior approach. In this case, the re-excision of a local recurrence would be extremely difficult. Results We describe a technique using arthroscopic guidance for radiofrequency thermoablation of a benign lesion in the tibial spines area. We report on an illustrative case. The patient so treated, reported immediate relief from the pain, and after two weeks, was free of pain. The biopsy performed before the treatment confirmed the radiological diagnosis of chondroblastoma. At one year of follow-up, the patient is without pain, with a 0-130°range of motion, has no activity limitations and is apparently free of disease. Conclusion This technique allows a radiofrequency thermoablation of a lesion in the tibial spines area and in the posterior tibial surface to be performed without opening the joint, monitoring the tibial plateau surface, probably decreasing the risk of cartilage damage. Unfortunately, in the case presented, the high pressure from the arthroscopy's pump broke the tibial plateau surface creating a communication to the tibial tunnel used for thermoablation.

  2. Diagnosis and treatment for primary bone tumor of the talus%距骨原发肿瘤的诊断与治疗

    Institute of Scientific and Technical Information of China (English)

    杨发军; 刘巍峰; 牛晓辉; 丁易

    2011-01-01

    Objective To analyze the clinical feature, surgical treatment and prognosis of primary bone tumor of the talus.Methods From January 1993 to December 2008, 21 patients of primary bone tumor and tumor-like lesion in the talus were retrospectively analyzed.The feature of bone tumor of the talus was analyzed from clinical, imaging and pathological aspects.All patients underwent surgical treatment.During postoperative follow-up, the function of patients was evaluated according to the criteria of musculoskeletal tumor society (MSTS).Results In all 21 patients,there were chondroblastoma (10 cases), giant cell tumor of bone (7 cases), osteoid osteoma (1 case), aneurysmal bone cysts (1 case), simple bone cysts (1 case), and osteofibrous dysplasia (1 case).Among 10 patients with chondroblastoma,the mean age was 22 years old (range; 10-35years).All 10 patients were performed curettage.1 patient was performed curettage and filled with bone cement.9 patients were performed curettage and bone grafting.No recurrence appeared among 9 patients with complete follow-up.The follow-up lasted for 15-87 months, and the median follow-up was 36 months.The function score (MSTS) was all 30.The mean age of onset of 7 patients with giant cell tumor of bone was 24 years old (range; 20-33years).Through image text, all cases suffered osteolytic damage.No calcification existed in ground substance.4 patients were primary cases and conducted curettage.3 cases relapsed.2 cases were performed astragalectomy and fusion of calcaneus and tibia.1 patient was applied crus amputation.3 patients had complete followup, and 2 patients were primary cases.Postoperatively, no recurrence happened within 10 and 32 months respectively.Recurrence happened in 1 case.No recurrence happened in follow-up lasting for 36 months.The function scores were respectively 26, 29 and 24.For other four patients with diagnosis, 1 patient with osteoid osteoma received lesion resection and bone grafting and 3 patients received

  3. Can p63 serve as a biomarker for giant cell tumor of bone? A Moroccan experience

    Directory of Open Access Journals (Sweden)

    Hammas Nawal

    2012-09-01

    Full Text Available Abstract Background Multinucleated giant cell-containing tumors and pseudotumors of bone represent a heterogeneous group of benign and malignant lesions. Differential diagnosis can be challenging, particularly in instances of limited sampling. The purpose of this study was to evaluate the contribution of the P63 in the positive and differential diagnosis of giant cell tumor of bone. Methods This study includes 48 giant cell-containing tumors and pseudotumors of bone. P63 expression was evaluated by immunohistochemistry. Data analysis was performed using Epi-info software and SPSS software package (version 17. Results Immunohistochemical analysis showed a P63 nuclear expression in all giant cell tumors of bone, in 50% of osteoid osteomas, 40% of aneurysmal bone cysts, 37.5% of osteoblastomas, 33.3% of chondromyxoide fibromas, 25% of non ossifiant fibromas and 8.3% of osteosarcomas. Only one case of chondroblastoma was included in this series and expressed p63. No P63 immunoreactivity was detected in any of the cases of central giant cell granulomas or langerhans cells histiocytosis. The sensitivity and negative predictive value (NPV of P63 immunohistochemistry for the diagnosis of giant cell tumor of bone were 100%. The specificity and positive predictive value (PPV were 74.42% and 59.26% respectively. Conclusions This study found not only that GCTOB expresses the P63 but it also shows that this protein may serve as a biomarker for the differential diagnosis between two morphologically similar lesions particularly in instances of limited sampling. Indeed, P63 expression seems to differentiate between giant cell tumor of bone and central giant cell granuloma since the latter does not express P63. Other benign and malignant giant cell-containing lesions express P63, decreasing its specificity as a diagnostic marker, but a strong staining was seen, except a case of chondroblastoma, only in giant cell tumor of bone. Clinical and radiological

  4. Cartilage tumors. Pathology and radiomorphology; Chondrogene Knochentumoren. Pathologie und Radiomorphologie

    Energy Technology Data Exchange (ETDEWEB)

    Uhl, M. [RKK-Klinikum Freiburg, Klinik fuer Diagnostische und Interventionelle Radiologie, Kinderradiologie und Neuroradiologie SJK, Freiburg (Germany); Herget, G. [Universitaetsklinik Freiburg, Department Orthopaedie und Traumatologie, Freiburg (Germany); Kurz, P. [Universitaetsklinik Freiburg, Pathologisches Institut, Freiburg (Germany)

    2016-06-15

    Primary cartilage-forming tumors of the bone are frequent entities in the daily work of skeletal radiologists. This article describes the correlation of pathology and radiology in cartilage-forming skeletal tumors, in particular, enchondroma, osteochondroma, periosteal chondromas, chondroblastoma and various forms of chondrosarcoma. After reading, the radiologist should be able to deduce the different patterns of cartilage tumors on radiographs, CT, and MRI from the pathological aspects. Differentiation of enchondroma and chondrosarcoma is a frequent diagnostic challenge. Some imaging parameters, e. g., deep cortical scalloping (more than two thirds of the cortical thickness), cortical destruction, or a soft-tissue mass, are features of a sarcoma. Osteochondromas are bony protrusions with a continuous extension of bone marrow from the parent bone, the host cortical bone runs continuously from the osseous surface of the tumor into the shaft of the osteochondroma and the osteochondroma has a cartilage cap. Chondromyxoid fibromas are well-defined lytic and eccentric lesions of the metaphysis of the long bones, with nonspecific MRI findings. Chondroblastomas have a strong predilection for the epiphysis of long tubular bones and develop an intense perifocal bone marrow edema. Dedifferentiated chondrosarcomas are bimorphic lesions with a low-grade chondrogenic component and a high-grade noncartilaginous component. Most chondrogenic tumors have a predilection with regard to site and age at manifestation. (orig.) [German] Primaere knorpelbildende Tumoren sind haeufige Entitaeten in der taeglichen Arbeit des Radiologen. Der Beitrag beschreibt die Korrelation von Pathologie und Radiologie knorpelbildender Skeletttumoren, insbesondere von Enchondrom, Osteochondrom, periostalem Chondrom, Chondroblastom, und verschiedenen Varianten des Chondrosarkoms. Nach Lesen des Beitrags kann der Radiologe die verschiedenen typischen Muster knorpelbildender Tumoren im Roentgenbild

  5. Inflammation and tumors of the temporal bone; Entzuendungen und Tumoren des Schlaefenbeins

    Energy Technology Data Exchange (ETDEWEB)

    Burian, M. [Universitaetsklinik fuer Hals-, Nasen- und Ohrenkrankheiten, Allgemeines Krankenhaus, Wien (Austria)

    1997-12-01

    The term `inflammation of the middle ear` covers a couple of deseases which range from the acute otitis media to the middle ear cholesteatoma. However, a clear characterization of a certain pathology is essential for any further treatment. Therefore this article presents a short overview about the different types of infections and their clinical manifestation. The tumors of the temporal bone show a great variety in their incidence. Even if tumors like the acoustic neurinoma or the paraganglioma are compareable common, the chondroblastoma of the temporal bone is absolutely rare. In spite of these differences the individual temporal bone neoplasias are shortly mentioned herein. (orig.) [Deutsch] Der Begriff Mittelohrentzuendung umfasst ein weites Spektrum von Krankheiten welches von der akuten Mittelohrentzuendung bis hin zum Cholesteatom reicht. Es soll in diesem Artikel eine kurze Uebersicht ueber die verschiedenen Entzuendungen gegeben werden, wobei vor allem auf eine klare Begriffsdefinition der einzelnen Entzuendungsformen und deren klinisches Erscheinungsbild geachtet wurde. Bei den Tumoren des Schlaefenbeins ist ein grosser Unterschied in der Inzidenz der einzelnen Tumoren gegeben. Waehrend Neubildungen wie das Akustikusneurinom oder das Paragangliom vergleichsweise haeufig im klinischen Alltag zu sehen sind, stellen Veraenderungen wie das Chondroblastom eine Raritaet dar. Trotz dieses Unterschieds im Vorkommen der verschiedenen Tumoren, wurde versucht, einen kurzen Gesamtueberblick ueber die Tumore des Mittel- und Innenohres zu geben. (orig.)

  6. Markers aiding the diagnosis of chondroid tumors: an immunohistochemical study including osteonectin, bcl-2, cox-2, actin, calponin, D2-40 (podoplanin), mdm-2, CD117 (c-kit), and YKL-40

    DEFF Research Database (Denmark)

    Daugaard, Søren; Christensen, Lise H; Høgdall, Estrid

    2009-01-01

    (s) for the different subgroups. Archival material from three extraskeletal myxoid chondrosarcomas, five chordomas, five chondromyxoid fibromas, five chondroblastomas and 25 chondrosarcomas was stained with antibodies against osteonectin, bcl-2, cox-2, actin, calponin, D2-40 (podoplanin), mdm-2, CD117 (c-kit) and YKL......) and extraskeletal myxoid chondrosarcomas (n=3) were positive for bcl-2. In contrast to all other tumors, two of three extraskeletal myxoid chondrosarcomas were also positive for CD17 and negative for osteonectin, cox-2, mdm-2 and actin. All five chordomas were negative for D2-40 and positive for mdm-2 and YKL-40....... The diagnosis of chondrosarcoma may be aided by its positivity for D2-40 and YKL-40 and its lack of reactivity for actin and CD117. This should be seen in the light of no reaction for D2-40 in chordomas and a corresponding lack of reaction for osteonectin, cox-2, mdm-2 and actin in extraskeletal myxoid...

  7. 成软骨细胞瘤的MRI征象分析

    Institute of Scientific and Technical Information of China (English)

    姚海泉; 林洪平; 张鹏; 李建全; 刘永桥

    2012-01-01

    @@ 成软骨细胞瘤(chondroblastoma,CB)是一种少见的软骨源性肿瘤,可发生于任何软骨化骨的骨骼,发生率在所有原发骨肿瘤中不足1%[1].本文回顾性分析经手术、病理证实的8例CB的MRI表现,并总结其特征,旨在提高对本病的认识及鉴别诊断能力. 一、资料与方法 1.一般资料:收集2004年8月至2010年5月湖北省应城市人民医院及外院经手术病理证实的CB患者8例,其中男7例,女1例,年龄14~18岁,平均15.2岁.所有患者术前均行MRI检查,在医院PACS系统中,5例行X线平片检查.临床表现为受累关节的疼痛、肿胀及活动受限.

  8. Thallium-201 scintigraphy for bone and soft tissue tumors

    Energy Technology Data Exchange (ETDEWEB)

    Tokuumi, Yuji; Tsuchiya, Hiroyuki; Sunayama, Chiaki; Matsuda, Eizo; Asada, Naohiro; Taki, Junichi; Sumiya, Hisashi; Miyauchi, Tsutomu; Tomita, Katsuro [Kanazawa Univ. (Japan). School of Medicine

    1995-05-01

    This study was undertaken to assess the usefulness of thallium-201 scintigraphy in bone and soft tissue tumors. Pre-therapy scintigraphy was undertaken in a total of 136 patients with histologically confirmed diagnosis, consisting of 74 with malignant bone and soft tissue tumors, 39 with benign ones, 12 with diseases analogous to tumors, and 11 others. Thallium activity was graded on a scale of 0-4: 0=background activity, 1=equivocal activity, 2=definitive activity, but less than myocardium, 3=definite activity equal to myocardium, and 4=activity greater than myocardium. In the group of malignant tumors, thallium-201 uptake was found in 80%, although it was low for chondrosarcoma (2/8) and malignant Schwannoma (one/3). The group of benign tumors, however, showed it in only 41%, being restricted to those with giant cell tumors, chondroblastoma, fibromatosis, and osteoid osteoma. Thallium-201 uptake was also found in all 8 patients with metastatic tumors. In 23 patients undergoing thallium imaging before and after chemotherapy, scintigraphic findings revealed a high correlation with histopathological findings. Thus, thallium-201 scintigraphy may be potentially used to distinguish malignant from benign bone and soft tissue tumors, except for a few histopathological cases, as well as to determine loco-regional metastases and response to chemotherapy. (N.K.).

  9. GIANT CELL-RICH LESIONS OF BONE AND JOINTS: A ONE YEAR PROSPECTIVE STUDY

    Directory of Open Access Journals (Sweden)

    Sri Nithisa H

    2016-07-01

    Full Text Available BACKGROUND Giant cell-rich lesions constitute a group of biologically and morphologically diverse bone and joint tumours. The common feature is presence of numerous multinucleated osteoclast-like giant cells. However, they differ from each other by in terms of clinical and radiographic features and in many cases by their distinct morphological features. METHODS All the bone and joint specimens with giant cell-rich lesions received in the period of one year were studied along with clinical and radiological data available. Gross and microscopic findings were noted. RESULTS In a period of one year, 10 cases of giant cell-rich lesions of bone and joints have been studied, which were and correlated with clinical and radiological findings. Five were lesions from bone and two were from joints, which are chondroblastoma, chondromyxoid fibroma, osteoclastoma, aneurysmal bone cyst, pigmented villonodular synovitis, giant cell lesion of tendon sheath, and tendinous xanthoma. CONCLUSION In the present study, variety of giant cell lesions of bone and joints are studied. Of which, the mean age in young patients being 20 years and in elderly patients being 50 years. The common site being lower end of femur.

  10. Aneurysmal Bone Cyst of the Calcaneus

    Directory of Open Access Journals (Sweden)

    Veysel Kaplanoglu

    2014-01-01

    Full Text Available Aneurysmal bone cysts (ABCs are benign, non-neoplastic, expansile, vascular, locally destructive lesions. The lesion may arise de novo (65% or secondarily (35% in pre-existing benign or malignant lesions (giant cell tumor, osteoblastoma, chondroblastoma, angioma, and others. The calcaneus is a rare localization for ABC, comprising only 1.6% of the cases. In this paper, we present a case of a female patient with a 3-month history of heel pain that got worse and was accompanied by swelling and difficulty in walking. The magnetic resonance images of the postero-lateral calcaneus showed a contrast-enhanced cystic lesion located in the medullary cavity; exophytic portion of the tumor extended into the soft tissue causing distinctive cortical thinning. Heterogeneous hyperintense septae formations and blood level components were also detected. After correlation with pathology results, the lesion was diagnosed as an ABC. Since an ABC of the calcaneus is a rarely seen phenomenon, we present the radiologic findings in this case and a review of the literature.

  11. Imaging diagnosis of bone tumor and tumor-like lesion in the talus%距骨肿瘤及瘤样病变的影像学特点

    Institute of Scientific and Technical Information of China (English)

    潘涛; 王林森; 胡永成; 王淑丽; 万业达

    2014-01-01

    Objective To research the variety and the imaging features of bone tumor and tumor-like lesions in the talus.Methods The imaging features of 33 cases of tumor and tumor-like lesions in the talus were reviewed retrospectively.All cases were confirmed by operation and pathology,All of 33 cases were performed X-ray examination,23 cases were examined by CT,and 11 cases were taken by MR.Results In 33 cases,24 cases were males,9 cases were females; including 7 cases of chondroblastoma(21.2%),7 cases of giant cell tumor(21.2%)(1 case of recurrence),6 cases of osteochondroma(18.2%),2 cases of osteoid osteoma(6.1%),7 cases of adjacent joint bone cyst(21.2%,2 cases of fibrous dysplasia of bone(6.1%),1 case of bone cyst(3%),1 case of malignant fibrous histiocytoma(MFH) of bone(3%).6 cases showed pathological fractures.The X-ray and CT imaging features of chondroblastoma,giant cell tumor,adjacent joint bone cyst,fibrous dysplasia of bone,bone cyst demonstrated cystic bony destruction.The common location of chondroblastoma were the posterior of talus(57%),expanding growth slightly,margin were mild osteosclerosis.The margin were osteosclerosis irregularly and osteal ridges showed in giant cell tumor.MRI features were different on pathologic basis,isointense and hypointense signal on T1WI and hyperintense signal on T2WI usually.The osteochondroma showed osseous protuberance connecting the talus,some cases showed calcification in the cap.The imaging of MFH in the talus X-ray and CT showed ill-defined osteolytic bony destruction,soft tissue-mass,no periosteal reactions and bone formation.MRI showed isointense and hypointense signal on T1WI and isointense and hyperintense signal on T2WI.The extent of tumour invasion clearly displayed.Conclusion Tumor and tumor-like lesion in the talus were rare.But there are great varieties.The benign tumor was more common than malignant tumor.Chondroblastoma,giant cell tumor,osteochondroma,osteoid osteoma and adjacent joint bone

  12. Intraosseous osteolytic lesions

    Energy Technology Data Exchange (ETDEWEB)

    Adler, C.P.; Wenz, W.

    1981-10-01

    Any pathological damage occurring in a bone will produce either an osteolytic or osteosclerotic lesion which can be seen in the macroscopic specimen as well as in the roentgenogram. Various bone lesions may lead to local destructions of the bone. An osteoma or osteoplastic osteosarcoma produces an osteosclerotic lesion showing a dense mass in the roentgenogram; a chondroblastoma or an osteoclastoma, on the other hand, induces an osteolytic focal lesion. This paper presents examples of different osteolytic lesions of the humerus. An osteolytic lesion seen in the roentgenogram may be either produced by an underlying non-ossifying fibroma of the bone, by fibrous dysplasia, osteomyelitis or Ewing's sarcoma. Differential diagnostic considerations based on the radiological picture include eosinophilic bone granuloma, juvenile or aneurysmal bone cyst, multiple myeloma or bone metastases. Serious differential diagnostic problems may be involved in case of osteolytic lesions occurring in the humerus. Cases of this type involving complications have been reported and include the presence of an teleangiectatic osteosarcoma as well as that of a hemangiosarcoma of the bone.

  13. 软骨母细胞瘤X线分析

    Institute of Scientific and Technical Information of China (English)

    林旭明; 许崇永

    2003-01-01

    目的:探讨软骨母细胞瘤(Chondroblastoma,CB)的X线特点,提高临床医师对本病的认识和诊断水平.方法:收集经手术病理证实的CB病例15例,回顾性分析其X线表现特征.结果:本组CB发生于长骨10例,非长骨5例,病灶多呈类圆形偏心性破坏,轻中度膨胀;8例见索条状骨嵴,分隔呈多囊状,6例灶内见棉团或斑点状钙化,4例灶周见硬化边.结论:CB表现特点为四肢长管骨骺区偏心性囊状病变,灶内伴有棉团或斑点状钙化.因其X线表现常缺乏特征性,鉴别诊断较为困难,确诊仍需病理学检查.

  14. Differential diagnosis of cystic bone tumors in childhood

    Energy Technology Data Exchange (ETDEWEB)

    Refior, H.J.; Stuerz, H.

    1982-09-01

    Skeletal changes leading to a suspicion of the presence of a tumour frequently occur in childhood with the roentgenological manifestation of a cyst. X-ray morphology can differ depending upon the localisation and the course. In childhood, however such findings are mainly classified as tumour-like bone lesions. This group comprises, inter alia, the juvenile bone cyst, the aneurysmatic bone cyst and fibrous dysplasia. However, it is necessary to exclude by differential diagnosis - even though the main age of manifestation is after completion of growth - genuine bone tumours with cystic phenomena, such as the giant cell tumour, chondroma or chondroblastoma. Verification of the diagnosis can be effected via radiologic-diagnostic methods such as tomography and angiography as well as computerized tomography. The use of scintigraphy of the skeleton can likewise be indicated. Numerous laboratory parameters can be used in individual cases to exclude certain diagnoses. Taking these aspects into consideration, the article reviews differential diagnosis of the most frequent skeletal affections in childhood. Great emphasis is given to the ranking and importance of the individual diagnostic methods.

  15. Trochanter/calcar preserving reconstruction in tumors involving the femoral head and neck

    Science.gov (United States)

    Cho, Hwan Seong; Lee, Young-Kyun; Ha, Yong-Chan; Koo, Kyung-Hoi

    2016-01-01

    AIM: To evaluate the results of hip reconstruction with extensive excision for tumor confined to the femoral head and neck. METHODS: We designed a resection preserving the greater trochanter and lower portion of calcar femorale, and utilized conventional total hip prosthesis. We retrospectively reviewed 7 patients, who underwent a wide resection and reconstruction using conventional hip prosthesis. There were 3 men and 4 women and their mean age was 42.5 years (22 to 65 years). The histologic diagnosis of each patient was low-grade osteosarcoma, diffuse large B-cell lymphoma, liposclerosing myxofibroma, intraosseous lipoma, chondroblastoma, giant cell tumor and focal intramedullary fibrosis. RESULTS: One patient with lymphoma died due to disease dissemination at 10 mo postoperatively and the remaining 6 patients were followed for a mean of 4.7 years (3 to 6 years). All patients were able to return to their daily activities and no patient had local recurrence. No radiographic signs of loosening, wear, and osteolysis were found at the last follow-up. CONCLUSION: Trochanter/calcar-preserving resection of the proximal femur and reconstruction using conventional total hip prosthesis, is a satisfactory treatment for tumors confined to the femoral head and neck. PMID:27458555

  16. Postradiation sarcoma of bone: review of 78 Mayo Clinic cases

    Energy Technology Data Exchange (ETDEWEB)

    Weatherby, R.P.; Dahlin, D.C.; Ivins, J.C.

    1981-05-01

    Postradiation sarcoma of bone is an uncommon but serious sequela of radiation therapy. Seventy-eight Mayo Clinic patients have been treated for sarcomas arising in irradiated bones. They received their initial radiotherapy for a wide variety of nonneoplastic and neoplastic conditions, both benign and malignant. Thirty-five sarcomas arose in bone that was normal at the time of radiotherapy, and 43 arose in irradiated preexisting osseous lesions. The latent period between radiotherapy and diagnosis of sarcoma averaged 14.3 years. Ninety percent of the postradiation sarcomas were either osteosarcomas or fibrosarcomas; chondrosarcoma, malignant (fibrous) histiocytoma, malignant lymphoma, Ewing's tumor, and metastasizing chondroblastoma also occurred. Prompt radical surgery, when feasible, is usually the treatment of choice for the sarcoma. About 30% of patients with sarcomas of the extremities or craniofacial bones survived 5 years without recurrence; there were no disease-free survivors among patients with tumors of the vertebral column, pelvis, or shoulder girdle. The low risk of sarcoma following radiotherapy for the treatment of cancer should not be a contraindication to its use in these patients; however, radiation therapy for benign bone tumors should be reserved for lesions that are not amenable to surgical treatment. An unusual case is also reported herein in which a fibrosarcoma was discovered in the humerus of a patient who had received radiotherapy 55 years previously for a verified osteosarcoma in the same site.

  17. Aneurysmal bone cyst secondary to a giant cell tumor of the patella: A case report

    Science.gov (United States)

    YU, XIAOLONG; GUO, RUNSHENG; FAN, CONGLIANG; LIU, HUCHENG; ZHANG, BIN; NIE, TAO; TU, YI; DAI, MIN

    2016-01-01

    The patella is an unusual location for primary and metastatic bone tumors to develop. The most frequently encountered primary osteolytic lesions at the patella include giant cell tumors of the bone (GCT), chondroblastoma and aneurysmal bone cysts (ABC). However, the presentation of an ABC originating secondary to a GCT at the patella is rare. The present study describes such a case in a 46-year-old female. The differential diagnosis of the condition was extensive. The patient underwent curettage and the addition of bone cement to fill the defect. Pathological analysis of the resected tissue demonstrated that the lesion was consistent with an ABC forming secondary to a GCT. A 3-month follow-up was completed subsequent to the surgery, with a computed tomography scan demonstrating no evidence of recurrence. However, frequent and continuous observations of the patient following diagnosis are planned in order to evaluate the long-term efficacy of the surgical treatment. To the best of our knowledge, the present study describes the third reported case in the literature of this rare, double synchronous, benign tumor located at the patella. PMID:26893764

  18. Bone multicentric epithelioid hemangioendothelioma of the lower and upper extremities with pulmonary metastases: A case report

    Science.gov (United States)

    ZHANG, HUA; FU, YANBIAO; YE, ZHAOMING

    2015-01-01

    The present study reports a rare case of bone multicentric epithelioid hemangioendothelioma (EH) involving the upper and lower extremities simultaneously, with visceral involvement of the lung. Osteolytic lesions were first identified in the right distal femur and proximal tibia. Slight increased radionuclide uptake was observed in the right shoulder joint on bone scintigraphy, however, this was ignored, as no clinical symptoms were present. The patient was initially misdiagnosed with multifocal chondroblastoma, and an extra-articular curettage of lesions was performed in the proximal tibia and medial femoral condyle, which was filled with bone cement. The histopathological diagnosis was corrected post-operatively following immunohistochemical analysis, which indicated EH, and subsequently, an amputation of the right leg at thigh level was performed. In addition, multiple lytic lesions in the right shoulder joint and pulmonary metastases were identified on whole-body radiological examination. Radiotherapy was administered to the right shoulder joint, however, the patient refused chemotherapy or further surgery. At 15 months after the initial surgery, the patient currently remains alive. This case indicates that an improved understanding with regard to the clinical features of this disease may prevent misdiagnosis and improve EH treatment. PMID:26137035

  19. Bony sequestrum: A radiologic review

    Energy Technology Data Exchange (ETDEWEB)

    Jennin, Felicie; Bousson, Valerie; Parlier, Caroline; Jomaah, Nabil; Khanine, Vanessa; Laredo, Jean-Denis [Lariboisiere Hospital, Department of Radiology, Paris (France)

    2011-08-15

    According to a pathological definition, a bony sequestrum is defined as a piece of devitalized bone that has been separated from the surrounding bone during the process of necrosis. However, the radiological definition of a sequestrum is different and refers to an image of calcification visible within a lucent lesion, completely separated from the surrounding bone, without referring to the vascular status and histological nature of the calcified tissue. The term ''button sequestrum'' has been used in calvarial lesions. The prototype conditions that may present with a bony sequestrum are osteomyelitis and skeletal tuberculosis. Other conditions such as radiation necrosis, eosinophilic granuloma, metastatic carcinoma, primary lymphoma of bone, aggressive fibrous tumors may also manifest as osteolytic lesions containing a sequestrum. In addition, some primary bone tumors produce a matrix that may mineralize and sometimes simulate a bone sequestrum. These include osteoid tumors (osteoid osteoma, osteoblastoma), cartilaginous tumors (chondroma and chondroblastoma), lipomatous tumors (lipoma), and benign fibrous tumors (fibromyxoma, myxoma, and desmoplastic fibroma). Therefore, various conditions may present at imaging as a small area of osteolysis containing central calcifications. However, a careful analysis of the sequestrum as well as the associated clinical and radiological findings often enables to point toward a limited number of conditions. (orig.)

  20. Osteoid osteoma and osteoid osteoma-mimicking lesions: biopsy findings, distinctive MDCT features and treatment by radiofrequency ablation

    Energy Technology Data Exchange (ETDEWEB)

    Becce, Fabio [Centre Hospitalier Universitaire Vaudois, Department of Diagnostic and Interventional Radiology, Lausanne (Switzerland); Universite Paris Descartes, Department of Radiology B, Hopital Cochin, AP-HP, Paris (France); Theumann, Nicolas [Centre Hospitalier Universitaire Vaudois, Department of Diagnostic and Interventional Radiology, Lausanne (Switzerland); Rochette, Antoine; Campagna, Raphael; Drape, Jean-Luc; Feydy, Antoine [Universite Paris Descartes, Department of Radiology B, Hopital Cochin, AP-HP, Paris (France); Larousserie, Frederique [Universite Paris Descartes, Department of Anatomic Pathology, Hopital Cochin, AP-HP, Paris (France); Cherix, Stephane; Mouhsine, Elyazid [Centre Hospitalier Universitaire Vaudois, Department of Orthopaedic and Traumatologic Surgery, Lausanne (Switzerland); Guillou, Louis [University Institute of Pathology, Centre Hospitalier Universitaire Vaudois, Lausanne (Switzerland); Anract, Philippe [Universite Paris Descartes, Department of Orthopaedic Surgery, Hopital Cochin, AP-HP, Paris (France)

    2010-10-15

    To report the biopsy findings of osteoid osteoma (OO) and OO-mimicking lesions, assess their distinctive multidetector computed tomography (MDCT) features and evaluate treatment by radiofrequency ablation (RFA). In this multicentric retrospective study, 80 patients (54 male, 26 female, mean age 24.1 years, range 5-48) with presumed (clinical and MDCT features) OO were treated by percutaneous RFA between May 2002 and June 2009. Per-procedural biopsies were always performed. The following MDCT features were assessed: skeletal distribution and location within the bone, size, central calcification, surrounding osteosclerosis and periosteal reaction. Clinical success of RFA was evaluated. Histopathological diagnoses were: 54 inconclusive biopsies, 16 OO, 10 OO-mimicking lesions (5 chronic osteomyelitis, 3 chondroblastoma, 1 eosinophilic granuloma, 1 fibrous dysplasia). OO-mimicking lesions were significantly greater in size (p = 0.001) and presented non-significant trends towards medullary location (p = 0.246), moderate surrounding osteosclerosis (p = 0.189) and less periosteal reaction (p = 0.197), compared with OO. Primary success for ablation of OO-mimicking lesions was 100% at 1 month, 85.7% at 6 and 12 months, and 66.7% at 24 months. Secondary success was 100%. Larger size, medullary location, less surrounding osteosclerosis and periosteal reaction on MDCT may help differentiate OO-mimicking lesions from OO. OO-mimicking lesions are safely and successfully treated by RFA. (orig.)

  1. Fluid-fluid level on MR image: significance in Musculoskeletal diseases

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Hye Won; Lee, Kyung Won [Seoul Naitonal University, Seoul (Korea, Republic of). Coll. of Medicine; Song, Chi Sung [Seoul City Boramae Hospital, Seoul (Korea, Republic of); Han, Sang Wook; Kang, Heung Sik [Seoul Naitonal University, Seoul (Korea, Republic of). Coll. of Medicine

    1998-01-01

    To evaluate the frequency, number and signal intensity of fluid-fluid levels of musculoskeletal diseases on MR images, and to determine the usefulness of this information for the differentiation of musculoskeletal diseases. MR images revealed fluid-fluid levels in the following diseases : giant cell tumor(6), telangiectatic osteosarcoma(4), aneurysmal bone cyst(3), synovial sarcoma(3), chondroblastoma(2), soft tissue tuberculous abscess(2), hematoma(2), hemangioma (1), neurilemmoma(1), metastasis(1), malignant fibrous histiocytoma(1), bursitis(1), pyogenic abscess(1), and epidermoid inclusion cyst(1). Fourteen benign tumors and ten malignant, three abscesses, and the epidermoid inclusion cyst showed only one fluid-fluid level in a unilocular cyst. On T1-weighted images, the signal intensities of fluid varied, but on T2-weighted images, superior layers were in most cases more hyperintense than inferior layers. Because fluid-fluid layers are a nonspecific finding, it is difficult to specifically diagnose each disease according to the number of fluid-fluid levels or signal intensity of fluid. In spite of the nonspecificity of fluid-fluid levels, they were frequently seen in cases of giant cell tumor, telangiectatic osteosarcoma, aneurysmal bone cycle, and synovial sarcoma. Nontumorous diseases such abscesses and hematomas also demonstrated this finding. (author). 11 refs., 1 tab., 4 figs.

  2. Chondrogenic Lesions of the Skeletal System Using Radiographs, CT and MRI

    Directory of Open Access Journals (Sweden)

    Akbar Bonakdarpour

    2011-05-01

    Full Text Available Benign Tumors: Chondroma, chondroblastoma,"nchondromyxoid fibroma, osteochondroma"nChondroma"n1. Enchondroma"n2. Periosteal Chondroma"n3. Enchondromatosis"n4. Metachondromatosis"nEnchondroma is a benign metaphyseal tumor. The"nmajor differential diagnoses are bone infarct and"nchondrosarcoma. Calcification in enchondroma"nhas a popcorn appearance and on radiographs and"nCT they may be counted. Calcified bone infarct"nhas an appearance similar to rotten metal. Central"nchondrosarcoma shows cortical erosion more than"ntwo thirds of the thickness of cortex and also periosteal"nreaction. Pain and growth of lesion in adulthood raises"nthe possibility of malignant transformation."nPeriosteal chondroma: This lesion arises from the"nperiosteum without involving the medullary bone."nThe most common location is the upper humerus."nEnchondromatosis reveals multiple enchondromas,"npredominantly involving one side of the skeleton."nMalignant transformation is the major complication"nof enchondromatosis. In malignant transformation,"nMRI shows that perichondrium is more than 1 cm"nthick in adults and more than 3 cm thick in children."nIn the hands and feet, enchondromatosis should not"nbe confused with fibrous dysplasia. Mafucci syndrome"nis enchondromatosis associated with cavernous"nhemangiomas with a prognosis worse than enchondr"nomatosis."nMultiple hereditary cartilaginous exostoses: This is"nof metaphyseal origin and pedunculated forms grow"naway from the adjacent joint. Sessile osteochondromas"nare broad based; if their surface is irregular they are"nsuspicious of malignancy. Pain and growth of the"nlesion after closure of the epiphyseal plate are warning"nsigns of malignant transformation. In malignant"ntransformation MRI shows that perichondrium is"nmore than 1 cm thick in adults and more than 3 cm"nthick in children."nChondroblastoma: This is a benign tumor, seen before"nclosure of epiphyseal plate, with a sclerotic border."n30 to 50% show

  3. The Differential Diagnosis of Cystic Change in Femur Head%股骨头囊性变的鉴别诊断

    Institute of Scientific and Technical Information of China (English)

    邢立峰; 周玲玲; 王颖; 修晓光

    2011-01-01

    Objective:To analysis the clinical and radiographic imaging feature about cystic change of femoral head (CCFH) and raise the method for differential diagnosis. Methods: From June 1996 to June 2010, 49 cases were diagnosed with CCFH by pathology or follow-up. Among them, there were 28 males and 21 females, with age ranging from 13 to 62 years (38. 2 years on average). There were 24 cases of osteonecrosis of femoral head (ONFH) ARCOstage II , 9 cases of primary hip osteoarthritis, 6 cases of developmental dysplasia of hip arthritis, 4 cases of rheumatoid arthritis,2 cases of an-kylosing spondylitis,2 cases of chondroblastoma of femoral head, 1 case of intraosseous ganglion, and 1 case of snovial her-niation pit. We retrospectively analyzed their clinical manifestation and radiographic imaging feature of CT and MR. Results :Two patients of rheumatoid arthritis was misdiagnosed as ONFH, 3 patients of primary hip osteoarthritis misdiag-nosed as ONFH, 3 of developmental dysplasia of hip arthritis misdiagnosed as ONFH,2 of ankylosing spondylitis misdiagnosed as ONFH. Patients of ONFH were made definite diagnosis and correct treatment. One case of chondroblastoma of femoral head received second operation for postoperative recurring result from not thoroughly erasion as benign lesion. Conclusion; CCFH exists in many hip joint diseases, and can be easily confused with ONFH. We should make a definite diagnosis according to their clinical manifestations and radiographic imaging features of CT and MR in order to avoid misdiagnosis and mistreatment.%目的 分析股骨头囊性变(cystic change of femoral head,CCFH)的临床及影像学特点,提出其鉴别诊断方法.方法 回顾性分析自1996年6月~2010年6月所诊治的CCFH病例49例(均经病理或随随访确诊),男28例,女21例;年龄13~62岁,平均年龄38.2岁;ARCOⅡ期股骨头坏死(osteonecrosis of femoral head,ONFH)24例,原发性髋骨性关节炎囊变9例,成人发育不

  4. 成软骨细胞瘤的影像学诊断

    Institute of Scientific and Technical Information of China (English)

    张云凤; 李惠明; 于静红

    2009-01-01

    目的:探讨成软骨细胞瘤(chondroblastoma)的影像学表现特点.方法:分析经手术病理或穿刺活检证实的成软骨细胞瘤患者10例.总结其X线平片、CT和MRI表现.结果:受累部位为股骨上端4例,肱骨上端3例,股骨下端1例,胫骨上端1例,肱骨下端1例.表现为病变部位圆形或不规则形局限性骨破坏区,部分内见钙化;MR成像:肿瘤在T1WI上呈低信号,而在T2WI上呈现不同程度的混杂信号,脂肪抑制T2WI上呈高信号.硬化边厚薄不一.病灶周围在X线和CT上见高密度骨质硬化区,MRI表现为骨髓水肿.骨膜反应在MRI上为长T1、短T2信号.邻近软组织肿胀,部分患者见关节积液.结论:成软骨细胞瘤影像学表现较有特征性,结合X线平片、CT和MRI能做出正确的诊断,但有一定的局限性.

  5. Diagnostic Efficacy of Radiology in the Diagnosis of Giant Cell Tumour of Bone

    Directory of Open Access Journals (Sweden)

    Afia Akhter

    2014-01-01

    Full Text Available Background: Giant cell tumour (GCT is an aggressive and potentially malignant lesion. Microscopic feature reveals osteoclast like giant cells in a mononuclear stromal cells background. The mononuclear stromal cell is interpreted as neoplastic. Objective: As radiological diagnosis is non invasive and cost effective in comparison to histopathological diagnosis, considering the patients’ compliance, the aim of the study was to observe the diagnostic efficacy of radiology in diagnosis of GCT. Materials and method: This cross sectional study was carried out in the department of Pathology, Delta Hopital Ltd., Dhaka, Bangladesh from July 2011 to December 2012. A total of 30 study subjects were enrolled in the study irrespective of age and sex. Biopsy material and relevant data of clinically suspected cases of GCT along with radiology report were sent from National Institute of Traumatology and Orthopaedic Rehabilitation (NITOR, Dhaka, Bangladesh. Histopathological diagnosis was made by expert pathologists. Results: Mean (±SD age of the study subjects was 29.20 (±7.34 years with highest number of patients were observed in 3rd decade and female was predominant (60% with a male female ratio of 1:1.5. Common site of GCT was around knee (50%. Among 30 clinically diagnosed GCT, 25 (83.3% cases were radiologically diagnosed as GCT, 2 (6.7% diagnosed as fibrous dysplasia, 1 (3.3% as chondroblastoma, 1 (3.3% as simple bone cyst and 1 (3.3% as aneurysmal bone cyst. However among 30 clinically diagnosed GCT, 28 (93.3% patients were histopathologically diagnosed as Giant cell lesion and rest 2 (6.7% patients diagnosed as fibrous dysplasia. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of radiological diagnosis of GCT were found to be 92.6%, 100.0%, 100.0%, 40.0% and 90.0%, respectively. Conclusion: Radiology can be effectively used as a screening tool in diagnosing GCT.

  6. Preoperative embolization of primary bone tumors: A case control study

    Science.gov (United States)

    Jha, Roushan; Sharma, Raju; Rastogi, Shishir; Khan, Shah Alam; Jayaswal, Arvind; Gamanagatti, Shivanand

    2016-01-01

    AIM: To study the safety and effectiveness of preoperative embolization of primary bone tumors in relation to intraoperative blood loss, intraoperative blood transfusion volume and surgical time. METHODS: Thirty-three patients underwent preoperative embolization of primary tumors of extremities, hip or vertebrae before resection and stabilization. The primary osseous tumors included giant cell tumors, aneurysmal bone cyst, osteoblastoma, chondroblastoma and chondrosarcoma. Twenty-six patients were included for the statistical analysis (embolization group) as they were operated within 0-48 h within preoperative embolization. A control group (non-embolization group, n = 28) with bone tumor having similar histological diagnosis and operated without embolization was retrieved from hospital record for statistical comparison. RESULTS: The mean intraoperative blood loss was 1300 mL (250-2900 mL), the mean intraoperative blood transfusion was 700 mL (0-1400 mL) and the mean surgical time was 221 ± 76.7 min for embolization group (group I, n = 26). Non-embolization group (group II, n = 28), the mean intraoperative blood loss was 1800 mL (800-6000 mL), the mean intraoperative blood transfusion was 1400 mL (700-8400 mL) and the mean surgical time was 250 ± 69.7 min. On comparison, statistically significant (P < 0.001) difference was found between embolisation group and non-embolisation group for the amount of blood loss and requirement of blood transfusion. There was no statistical difference between the two groups for the surgical time. No patients developed any angiography or embolization related complications. CONCLUSION: Preoperative embolization of bone tumors is a safe and effective adjunct to the surgical management of primary bone tumors that leads to reduction in intraoperative blood loss and blood transfusion volume. PMID:27158424

  7. Reconstruction by bone transport after resection of benign tumors of tibia: A retrospective study of 38 patients

    Science.gov (United States)

    Borzunov, Dmitry Y; Balaev, Pavel I; Subramanyam, Koushik N

    2015-01-01

    Background: The commonly used reconstructive options after post resection defects in bone tumors like megaprosthesis, autograft, allograft, bone graft substitutes and recycled bone have their own demerits on a long term. Bone transport that regenerates patient's own bone is a less explored option of reconstruction after resection of benign bone tumors and reports on this are limited. This technique is very much relevant in tibia where Ilizarov fixator is surgeon and patient friendly. We report our experience. Materials and Methods: This is a retrospective series of resection and bone transport in 38 patients with benign tumor of tibia. There were 14 males and 24 females with mean age of 23.40 years (range 9–40 years). Lesion was located in proximal third tibia in 27, middle third in two and distal third in nine patients. The diagnosis was giant cell tumor in 32, chondroblastoma in three, chondromyxoid fibroma, enchondroma and desmoplasic fibroma in one patient each. The resection was intercalary in 28 and transarticular in 10 patients. Osteosynthesis was monofocal in three, bifocal in 31 and polyfocal in four cases. Results: Mean followup was 7.22 years (range 1.5–15 years). Mean resection length was 10.21 cm (range 3–22 cm). The mean duration of external fixator was 308.03 days (range 89–677 days) and mean external fixator index was 36.14 days/cm (range 16.84–97.43 days/cm). Twelve patients had difficulties in the form of 11 problems and five obstacles that were successfully managed. None of the patients had local recurrence of tumor or any long term complication. Mean Musculo-skeletal Tumour Society score at final followup was 27.18 (90.60%). Conclusions: Bone transport is an excellent option after resection of benign tumors of tibia with good local control and functional outcome, despite minor difficulties that need timely management. PMID:26538757

  8. Chondroma of the skull base and maxilla

    Directory of Open Access Journals (Sweden)

    Kiralj Aleksandar

    2007-01-01

    Full Text Available Introduction. Chondromas are uncommon benign tumors of cartilaginous origin. Although chonodroma of the jaw is extremely rare, the commonly involved are the anterior portion of the maxilla, condyle and coronoid process. A chondroma is a painless, slow growing tumor causing destruction and exfoliation of teeth. On a radiograph, the tumor appears as a cyst-like radiolucent lesion, while some are sclerotic. The borders are usually ill-defined. Irregular calcifications may be seen with radiolucencies and then it is an osteochondroma. Material and Methods. We present a patient with a resected and histologically proven chondroma of the skull base and maxilla. A 65-year-old female was admitted to our clinic with swelling and breathing difficulties. MRI showed a large soft tissue mass of the skull base and maxilla. Clinicopathological and radiological features were examined by computed tomography (CT and magnetic resonance imaging (MRI. Discussion and Conclusion. Chondromyxoid fibroma (CMF is a rare, benign cartilaginous tumor that often occurs in the metaphyses of proximal tibia, proximal and distal femur and small bones of the foot. The differential diagnosis is wide and includes simple or aneyrismal bone cyst, giant cell tumor, nonossifying fibroma, fibrous dysplasia, enchondroma, chondroblastoma, eosinophilic granuloma and fibrous cortical defect. Our case demonstrates an uncommon occurrence in the maxillary sinus: CMF with nasal, pterygoid and orbital infiltration. In the diagnosis of an intracranial chondrocytic tumor, it is important to distinguish it from enchondroma and chondrosarcoma. MR provides a detailed assessment of soft tissue masses of the craniofacial region, while CT offers superior analysis of bone structure involvement. The present case underlines the importance of MR examination in the diagnosis of soft tissue masses in the craniofacial region.

  9. 耳源性脑脓肿CT表现和鉴别诊断%CT manifestations and differential diagnosis of otogenic brain abscesses

    Institute of Scientific and Technical Information of China (English)

    彭强; 贺际宏; 李波

    2011-01-01

    目的 提高对耳源性脑脓肿CT表现的认识和诊断水平.方法 对21例脑脓肿患者行多层螺旋CT平扫与增强扫描后对其CT表现进行回顾性分析.结果 病灶位于颞叶16例,小脑半球4例,顶叶1例;CT平扫表现为不规则片状低密度影,边界模糊,占位效应不明显16例;平扫表现为类圆形囊状低密度影5例,其中2例内有液气平面,注射造影剂后,斑片状、脑回样强化、环状强化17例;无明显强化4例.结论 多层螺旋CT在耳源性脑脓肿的诊断中具有重要诊断价值.%Objective To improve the otogenic brain abscesses CT manifestations of understanding and diagnostic level. Methods Twenty - one cases of brain abscesses patients were done MDCT flat after Saul and enhancement of the CT scan showed were retrospectively analyzed. Results The temporal lobe chondroblastoma in 16 cases, cerebellum involving 4 cases, the parietal lobe 1; CT flat for irregular sheets Saul performance, low density shadow fuzzy boundaries placeholder effect is not obvious, 16 cases; Flat performance for the class round Saul cystic low density shadow 2 cases in 5 cases, including in hydraulic pneumatic plane, contrast -enhanced sonogram obtained after, patchy, brain return sample aggrandizement, cricoid strengthening 17 cases; No obvious strengthening 4 cases. Conclusions In multislice CT otogenic diagnosis of brain abscess has important diagnostic value.

  10. 带翼型髋臼加强杯在重建髋臼肿瘤切除后骨缺损中的应用%UTILIZATION OF REINFORCED ACETABULAR CAGES WITH CAUDAL FLANGE IN RECONSTRUCTING PELVIC DEFECT AFTER ACETABULAR TUMOR RESECTION

    Institute of Scientific and Technical Information of China (English)

    李大森; 郭卫; 杨荣利; 汤小东; 曲华毅

    2011-01-01

    Objective To evaluate the surgical procedure of reinforced acetabular cage with caudal flange in reconstruction of pelvic defect after acetabular tumor resection. Methods Between June 2003 and December 2009, 25 patients with Harrington class III pelvic defect underwent reconstruction with a reinforced acetabular cage with caudal flange and total hip arthroplasty (THA). There were 13 males and 12 females with an average age of 51.2 years (range, 13-73 years). The main clinical manifestations included hip pain and buttock pain, with a median disease duration of 6 months (range, 1-96 months). Pathological findings showed 18 cases of metastasis, 3 cases of multiple myeloma, 1 case of non-Hodgkin's lymphoma, 1 case of grade I chondrosarcoma, 1 case of giant cell tumor, and 1 case of chondroblastoma. For the patient with chondroblastoma, THA with LINK RIBBED system was used. An artificial total hip system made in China was used in 6 patients and LINK SP II system was used in the other 18 patients. Results No patients died perioperatively. Deep infection and hip dislocations occurred inI and 2 patients, respectively. At last follow-up, 8 of 18 patients with metastasis died of cancer and the average survival time wasII months. The other 10 who were alive were followed up 15 months on average. One patient with multiple myeloma died of pulmonary infection at 21 months after operation and the other 2 with multiple myeloma and 1 with lymphoma were alive with an average follow-up of 17 months. The patient with grade I chondrosarcoma and patient with chondroblastoma were followed up 58 and 12 months, respectively, without recurrence. Recurrence occurred in the patient with giant cell tumor at 19 months after operation. Loosening of implant occurred in 3 patients because of local tumor recurrence. For the 23 patients at 6 months after operation, the mean Musculoskeletal Tumor Society (MSTS) 93 score was 81% (range, 57%-93%). Conclusion Reinforced acetabular cage with caudal

  11. Prevalence, extension and characteristics of fluid-fluid levels in bone and soft tissue tumors

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    Dyck, P. van; Venstermans, C.; Gielen, J.; Parizel, P.M. [University Hospital Antwerp, Department of Radiology, Edegem (Belgium); Vanhoenacker, F.M. [University Hospital Antwerp, Department of Radiology, Edegem (Belgium); AZ St-Maarten, Department of Radiology, Duffel/Mechelen (Belgium); Vogel, J. [Leiden University Medical Centre, Department of Orthopedics, Leiden (Netherlands); Kroon, H.M.; Bloem, J.L. [Leiden University Medical Centre, Department of Radiology, Leiden (Netherlands); Schepper, A.M.A. de [University Hospital Antwerp, Department of Radiology, Edegem (Belgium); Leiden University Medical Centre, Department of Radiology, Leiden (Netherlands)

    2006-12-15

    The purpose of this study was to determine the prevalence, extension and signal characteristics of fluid-fluid levels in a large series of 700 bone and 700 soft tissue tumors. Out of a multi-institutional database, MRI of 700 consecutive patients with a bone tumor and MRI of 700 consecutive patients with a soft tissue neoplasm were retrospectively reviewed for the presence of fluid-fluid levels. Extension (single, multiple and proportion of the lesion occupied by fluid-fluid levels) and signal characteristics on magnetic resonance imaging of fluid-fluid levels were determined. In all patients, pathologic correlation was available. Of 700 patients with a bone tumor, 19 (10 male and 9 female; mean age, 29 years) presented with a fluid-fluid level (prevalence 2.7%). Multiple fluid-fluid levels occupying at least one half of the total volume of the lesion were found in the majority of patients. Diagnoses included aneurysmal bone cyst (ten cases), fibrous dysplasia (two cases), osteoblastoma (one case), simple bone cyst (one case), telangiectatic osteosarcoma (one case), ''brown tumor'' (one case), chondroblastoma (one case) and giant cell tumor (two cases). Of 700 patients with a soft tissue tumor, 20 (9 males and 11 females; mean age, 34 years) presented with a fluid-fluid level (prevalence 2.9%). Multiple fluid-fluid levels occupying at least one half of the total volume of the lesion were found in the majority of patients. Diagnoses included cavernous hemangioma (12 cases), synovial sarcoma (3 cases), angiosarcoma (1 case), aneurysmal bone cyst of soft tissue (1 case), myxofibrosarcoma (1 case) and high-grade sarcoma ''not otherwise specified'' (2 cases). In our series, the largest reported in the literature to the best of our knowledge, the presence of fluid-fluid levels is a rare finding with a prevalence of 2.7 and 2.9% in bone and soft tissue tumors, respectively. Fluid-fluid levels remain a non-specific finding and can

  12. Curettage of benign bone tumors and tumor like lesions: A retrospective analysis

    Directory of Open Access Journals (Sweden)

    Zile Singh Kundu

    2013-01-01

    Full Text Available Background: Curettage is one of the most common treatment options for benign lytic bone tumors and tumor like lesions. The resultant defect is usually filled. We report our outcome curettage of benign bone tumors and tumor like lesions without filling the cavity. Materials and Methods: We retrospectively studied 42 patients (28 males and 14 females with benign bone tumors who had undergone curettage without grafting or filling of the defect by any other bone graft substitute. The age of the patients ranged from 14 to 66 years. The most common histological diagnosis was that of giant cell tumor followed by simple bone cyst, aneurysamal bone cyst, enchondroma, fibrous dysplasia, chondromyxoid fibroma, and chondroblastoma and giant cell reparative granuloma. Of the 15 giant cell tumors, 4 were radiographic grade 1 lesions, 8 were grade 2 and 3 grade 3. The mean maximum diameter of the cysts was 5.1 (range 1.1-9 cm cm and the mean volume of the lesions was 34.89 cm 3 (range 0.94-194.52 cm 3 . The plain radiographs of the part before and after curettage were reviewed to establish the size of the initial defect and the rate of reconstitution, filling and remodeling of the bone defect. Patients were reviewed every 3 monthly for a minimum period of 2 years. Results: Most of the bone defects completely reconstituted to a normal appearance while the rest filled partially. Two patients had preoperative and three had postoperative fractures. All the fractures healed uneventfully. Local recurrence occurred in three patients with giant cell tumor who were then reoperated. All other patients had unrestricted activities of daily living after surgery. The rate of bone reconstitution, risk of subsequent fracture or the incidence of complications was related to the size of the cyst/tumor at diagnosis. The benign cystic bone lesions with volume greater than approximately 70 cm 3 were found to have higher incidence of complications. Conclusion: This study

  13. 髋周良性骨病的影像诊断%Imaging Diagnosis of Benign Osteopathy around the Hip Joint

    Institute of Scientific and Technical Information of China (English)

    唐浩; 邹丹凤; 廖昕; 陈卫国

    2011-01-01

    目的 评价57例髋周良性骨病的影像学表现.方法 回顾性分析57例经穿刺活检或手术病理证实的髋周良性骨病的影像学表现.全部病例均行X线平片检查,32例同时行CT检查,21例行MRI检查.结果 骨囊肿13例,动脉瘤样骨囊肿16例,骨巨细胞瘤6例,软骨母细胞瘤2例(合并动脉瘤样骨囊肿1例),骨母细胞瘤1例,骨样骨瘤3例,骨化性纤维瘤2例,非骨化性纤维瘤3例,骨纤维异常增殖症6例,嗜酸性肉芽肿3例,骨结核2例.结论 髋周良性骨病以骨囊肿及动脉瘤样骨囊肿为好发病种.%Objective To evaluate imaging findings of benign osteopathy around the hip joint. Methods Fifty-seven cases with histologically confirmed benign osteopathy around the hip joint were reviewed. Radiography was performed in all cases,CT in 32 patients and MRI in 21 cases were done. Results There were simple bone cyst was in 13 cases,aneurysmal bone cyst in 16 cases,giant cell tumor in 6 cases,chondroblastoma in 2 cases (one case accompanied with aneurysmal bone cyst) osteoblastoma in 1 case,osteoid osteoma in 3 cases,ossifying fibroma in 2 cases, non-ossifying fibroma in 3 cases,fibrous dysplasia of bone in 6 cases, eosinophilic granuloma in 3 cases and bone tuberculosis in 2 cases. Conclusion Simple bone cyst and aneurysmal bone cyst are common benign osteopathy around the hip joint.

  14. Effect on biological characteristics of rat nucleus pulposus mesenchymal stem cell under different concentration fetal bovine serum%不同体积浓度胎牛血清对大鼠髓核间充质干细胞生物学特性的影响

    Institute of Scientific and Technical Information of China (English)

    宋亮; 张宁; 关晓明; 陈辉; 马迅

    2014-01-01

    The expression of Sox2,Nanog were assessed by PCR. ③The third generation NPMSCs were induced and cultured by osteogenesis,chondroblastomas and lipoblast culture in incubator with 37℃,21%O2,5%CO2 condition. After 2 weeks,dyed them and observed the ability of osteoporosis,chondroblastomas and lipoblast. ④Cultured the third genera-tion NPMSCs with different volume concentrations of the DMEM-F12 serum (0%,5%,10%,20%,30%) under condition of 37℃,21%O2,5%CO2 for 72 hours. The cell proliferation was detected by CCK-8 method in different groups ,and the proteogly-can expression of the mRNA of SOX9,collagenⅡ, were assessed by RT-PCR,and flow cytometry was used to detect apoptosis. Results ①The osteogenic and cartilage ability of the rat NPMSCs were strong,and adipogenic capacity was poor. CD29,CD90, CD105 were highly expressed, CD24 and CD34 were poorly expressed,and Sox2,Nanog were highly expressed. ②With the vol-ume of serum concentration increasing,OD value increased,and the apoptosis rate of NPMSCs decreased,expression of the mR-NA of cell proteoglycans,collagen type Ⅱ,SOX9 gene increased. Conclusion ①The rat NPMSCs has the biological charac-teristics like mesenchymal stem cells;②Extracellular nutrition affects the proliferation,secretion,apoptosis of the rat NPMSCs.

  15. One-center bone tumors in the foot:an epidemiological analysis of 258 cases%单中心足部骨肿瘤258例临床流行病学分析

    Institute of Scientific and Technical Information of China (English)

    廖锋; 徐海荣; 牛晓辉

    2015-01-01

    目的:探究足部骨肿瘤流行病学特点。方法回顾1957年8月至2014年7月,北京积水潭医院骨肿瘤科诊治的258例足部骨肿瘤患者资料,分析其性别、年龄、病理诊断、发病部位及影像特点。结果男174例,女84例,年龄7~76岁,平均27.9岁。病变多位于跟骨、趾骨、距骨、跖骨,少见于足舟骨、楔骨和骰骨。恶性骨肿瘤38例,包括软骨肉瘤13例、骨肉瘤8例、Ewing 肉瘤6例、转移性肿瘤5例;中间型肿瘤81例,包括软骨母细胞瘤36例、骨巨细胞瘤29例、动脉瘤样骨囊肿10例、软骨粘液样纤维瘤3例;良性肿瘤139例,包括内生软骨瘤37例、甲下外生性骨疣27例、单纯性骨囊肿26例、骨软骨瘤19例、骨样骨瘤12例、骨脂肪瘤10例。结论足部骨肿瘤好发于中青年男性,多为良性或中间型。%Objective To explore epidemiological features of bone tumors in the foot and further to guide clinical diagnosis.Methods From August 1957 to July 2014, 258 patients were included. Gender, age, location, pathological and radiological data were reviewed.Results There were 174 males and 84 females, with a mean age of 27.9 years ( range: 7-76 years ). Bone tumors of the foot had particular predilections in the calcaneus, talus, phalanx and metatarsal bones. Thirty-eight cases of malignant tumors included chondrosarcoma ( 13 cases ), osteosarcoma ( 8 cases ), Ewing sarcoma ( 6 cases ) and metastatic tumors ( 5 cases ). Eighty-one cases of intermediate bone tumors included chondroblastoma ( 36 cases ), giant cell tumors of bone ( 29 cases ), aneurysmal bone cysts ( 10 cases ) and chondromyxoid ifbroma ( 3 cases ). One hundred and thirty-nine benign bone tumors included enchondroma ( 37 cases ), subungual exostosis ( 27 cases ), simple bone cyst ( 26 cases ), osteochondroma ( 19 cases ), osteoid osteoma ( 12 cases ) and lipoma of bone ( 10 cases ).Conclusions Benign and intermediate tumors are most common in

  16. Surgical treatment for giant tumors of the pelvis%骨盆巨大肿瘤的手术治疗

    Institute of Scientific and Technical Information of China (English)

    齐波; 丁晶; 徐永清; 阮默; 林月秋

    2014-01-01

    Objective To explore the method of surgical treatment for giant tumors of the pelvis. Methods 21 cases with giant tumors of the pelvis were hospitalized in the period from Jan. ,2000 to Dec. ,2007,17 male and 4 female,the average age was 55 years old(from 35 to 65),including 8 cases of sacral chordoma,5 cases of iliac chondrosarcoma,4 cases of chondroblastoma,3 cases of giant cell tumor(GCT)of bone and 1 case of osteosarcomas;all the patients underwent surgical resection with temporary blocking of bilateral or unilateral common iliac arteries. Results Follow-up lasted from 0. 5 year to 6 years with the average of 4 years;local reoccurrence was found in 4 cases of sacral chordom,1 case died of lung metastases and systemic failure,1 case died of lung metastases 1. 5 year after surgery;no reoccurrence was found in other cases;8 cases had discomfort with pain of unknown causes in the operation sites. Conclusions Temporary blocking of bilateral or unilateral common iliac artery in operation can obviously reduce the bleeding, make a complete resection of the tumors at most and maintain the stability of the pelvis,which raises the surgical effect on patients with giant tumors of pelvis.%目的:探讨骨盆巨大肿瘤的手术治疗方法。方法我院自2000年1月~2007年12月共收治21例骨盆巨大肿瘤患者,男17例,女4例,平均55(35~65)岁。其中骶骨脊索瘤8例,髂骨软骨肉瘤5例,软骨母细胞瘤4例,骨巨细胞瘤3例,骨肉瘤1例,均采用双侧或单侧髂总动脉暂时阻断的方法行手术切除。结果所有患者术后获得0.5~6年(平均4年)随访,脊索瘤4例局部复发,1例死于肺部转移全身衰竭,1例于术后1年半死于肺部转移,其余无复发;8例出现手术部位不明原因疼痛不适。结论术中采用双侧或单侧髂总动脉暂时阻断的方法可明显减少术中出血,尽量彻底切除瘤体及维持骨盆稳定性等,可明显提高骨盆巨大肿瘤患者的手术疗效。

  17. Seventeen Cases of Calcaneal Tumors and Tumor-like Lesions%跟骨肿瘤与瘤样病变17例

    Institute of Scientific and Technical Information of China (English)

    张智长; 杨庆诚; 董扬; 曾炳芳

    2011-01-01

    目的 足踝部肿瘤尤其是跟骨肿瘤非常少见,多数临床医师对跟骨肿瘤认识较少,延误诊断和治疗不当很常见.总结并回顾我院治疗的跟骨肿瘤病例及相关文献,评价其诊断及治疗方法.方法 自2003年1月至2007年12月共收治17 例跟骨原发肿瘤,其中男性13 例,女性4 例;年龄13~67 岁,平均年龄31.5 岁.均行病灶刮除植骨术.结果 术后病理证实,跟骨脂肪瘤7 例(8足),软骨母细胞瘤6 例(6足,其中5 例继发动脉瘤样骨囊肿),单纯性骨囊肿2 例(2足),骨内腱鞘囊肿2 例(2足).17 例均获随访,随访时间29~76个月,平均52个月.术后均无复发病例.结论 跟骨肿瘤少见,多为良性,原发或转移性恶性肿瘤罕见.诊断依赖于临床表现、影像学检查和病理检查,多数肿瘤通过临床表现、影像学检查可以明确性质.对良性肿瘤可以随访观察,常规手术方案为经外侧入路行病灶刮除植骨.恶性肿瘤多采取膝下截肢.%Objective Tumors occurred in foot and ankle especially in heel are rare, most clinicians know little of the calcaneal tumors,delayed diagnosis and improper treatment are common. So,review to our hospital for treatment of calcaneal tumor cases,review and summarize the literature and evaluate its diagnostic and treatment methods. Methods Sinccan 2003 to Dec2007,17 cases of primary calcaneal tumors,including 13 males and 4 females,average age 31.5 years,underwent curettage and bone graft. Results Pathologically confirmed,calcaneus lipoma in 7 patients (8 feet), 6 cases of chondroblastoma (6 feet), 5 patients with secondary aneurysmal bone cyst,simple bone cyst in 2cases(2 feet),bone Ganglion cyst in 2 patients (2 feet). 17 cases were followed up for 29-76 months (mean 52 months). There was no recurrence. Conclusion Tumors occurred in calcaneus are rare,most are benign,primary or metastatic malignancy are rare. Diagnosis depends on clinical manifestations,imaging and pathological

  18. Image analysis of tumor and tumor-like lesion in proximal femur%股骨近端肿瘤与肿瘤样病变的影像学分析

    Institute of Scientific and Technical Information of China (English)

    何东; 陈兴灿; 潘永青; 赵凯宇; 毛佳伟

    2011-01-01

    Objective To analyse the images of bone tumor and tumor-like lesion in proximal femur, and discuss the clinical significance.Methods 49 patients who were confirmed by pathological results and treated in our hospital were involved.Normotopia image of the hip joint was taken for all patients.32 underwent CT scan, and 18 underwent MRI.We retrospectively analysed the radiological manifestations of the tumor and tumor-like lesion in the proximal femur.Results The lesions were bone cyst (n=16), fibrous hyperplasia of bone (n=11), giant cell tumor of bone (n=8), metastatic tumor (n=5), general lymphadenomatosis of bones (n=2), eosinophilic granuloma(n=2), osteoidosteoma (n=1), enchondroma (n=1), osteoblastoma (n=1), chondroblastoma (n=1), osteogenic sarcoma (n=1), and aneurysmal bone cyst (n=2).All the cases had some common and special characteristics in terms of the lesion number, size,morphous, bouncary, intemal structure, periosteal reaction, soft tissue tumor and pathologic fracture.Conclusions The incidence of tumor-like lesions is higher than that of bone tumor in proximal femur.A variety of imaging methods used in combination plays an important role in the diagnosis and differential diagnosis, and will be conducive to the choice of treatment options, the prenention of recurrence and the evaluation of prognosis.%目的 分析股骨近端肿瘤与肿瘤样病变的影像学表现,探讨其临床意义.方法 搜集49例在我院接受治疗并有病理结果的患者,术前均摄髋关节X线正位片,32例行CT检查,18例行MRI检查,回顾性分析股骨近端肿瘤与肿瘤样病变的影像学表现.结果 骨囊肿16例,骨纤维组织增殖症11例,骨巨细胞瘤8例,骨转移瘤5例,多发性骨髓瘤2例,嗜酸性肉芽肿2例.骨样骨瘤、内生软骨瘤、骨母细胞瘤、软骨母细胞瘤、骨肉瘤各1例,动脉瘤样骨囊肿2例均为伴发.所有病例在病变部位、数目、大小、形态、边界、内部结构、骨膜反应、软组织

  19. 肿瘤型膝关节假体术后并发症214例分析%Complications after the reconstruction of bone defects in the knee with tumor endoprostheses

    Institute of Scientific and Technical Information of China (English)

    覃澍; 董扬

    2016-01-01

    Objective To retrospectively analyze the prosthesis survival and complications after custom-made tumor prosthesis replacement of the knee joint. Methods Data of 214 patients with bone tumors around knee joints who underwent custom-prosthetic replacement from January 2003 to January 2013, were retrospectively analyzed. The diagnoses were osteosarcoma ( n = 136 ), giant cell tumor ( n = 49 ), aneurysmal bone cyst ( n = 1 ), fasciculated sarcoma ( n = 3 ), malignant fibrous histiocytoma ( n = 10 ), chondrosarcoma ( n = 6 ), chondroblastoma ( n = 1 ), metastatic tumor ( n = 4 ) and other types of bone tumors ( n = 3 ). The distal femur was affected in 150 patients and the proximal tibia in 64. Results Totally 187 patients were followed up for a mean period of 47 months ( range: 16 -122 months ). Complications occurred in 47 patients: early stage infection or nonunion of wounds ( n = 15 ), peroneal palsy ( n = 3 ), late infection ( n = 5 ), aseptic loosening ( n = 15 ), breakage of the prosthesis ( n = 4 ) and periprosthetic fracture ( n = 5 ). Conclusions The complication rate of proximal tibia tumor is higher than the rate of the distal femur. Common complications of tumor prosthesis replacement of the knee joint are: aseptic loosening, infection or nonunion of wounds, peroneal palsy, late infection, aseptic loosening, breakage of prosthesis and periprosthetic fracture. Common complications of tumor prosthesis replacement of the knee joint can be treated and prevented.%目的:分析肿瘤型膝关节假体置换术后并发症的发生情况以及处理方式。方法回顾性分析2003年1月至2012年1月,在我院行膝关节假体置换的214例术后并发症发生情况;其中骨肉瘤136例,骨巨细胞瘤49例,动脉瘤样股囊肿1例,梭形细胞肉瘤3例,恶性纤维组织细胞瘤10例,软骨肉瘤6例,软骨母细胞瘤1例,软骨细胞瘤1例,转移癌4例,其它骨肿瘤3例;根据位置分类,发生于股骨远端150

  20. Imaging diagnosis of benign osteopathy in proximal femur%股骨近端良性骨病的影像特征研究

    Institute of Scientific and Technical Information of China (English)

    程少容; 王鹰; 孙志强; 阳昱恒; 沈桂萍; 高松; 佘小夫

    2012-01-01

    Objective: To evaluate imaging findings of benign osteopathy in proximal femur and to optimize pre opera tive staging. Methods:56 cases of histologically confirmed benign osteopathy in proximal femur were involved. Radiogram of the hip joint was taken for all patients with additional examination of CT in 32 patients and MRI in 21 patients. Results: There were simple bone cyst in 15 cases,fibrous dysplasia in 11 cases,osteochondroma in 6 cases,aneurysmal bone cyst in 5 cases,giant cell tumor in 5 cases,chondroblastoma in 3 cases,osteoblastoma in 3 cases,ossifying fibroma in 2 cases,non os sifying fibroma in 1 case,benign fibrous histiocytoma in 1 case,enchondroma in 1 case,desmoplastic fibroma in 1 case,chon dromyxoid fibroma in 1 case and osteoid osteoma in 1 case. All these cases had common characteristics in terms of the lesion number,size,boundary,internal structure,soft tissue reaction and pathologic fracture. Conclusion:There are different kinds of benign osteopathy in proximal femur. Simple bone cyst and fibrous dysplasia are more frequently seen. JVIore than one lm aging methods used in combination play an important role in the diagnosis and differential diagnosis, and will be conducive to the choice of treatment and evaluation of prognosis.%目的:分析股骨近端良性骨肿瘤与肿瘤样病变的影像学特征表现,探讨其临床意义.方法:回顾性分析56例经手术病理证实的股骨近端良性骨肿瘤和肿瘤样病变的影像学特征表现.全部病例均行X线检查,其中30例同时行CT检查,25例行MRI检查.结果:骨囊肿15例,骨纤维结构不良11例,骨软骨瘤6例,动脉瘤样骨囊肿5例,骨巨细胞瘤5例,软骨母细胞瘤和骨母细胞瘤各3例,骨化性纤维瘤2例,非骨化性纤维瘤1例,纤维组织细胞瘤1例,内生软骨瘤1例,韧带样纤维瘤1例,软骨粘液样纤维瘤1例,骨样骨瘤1例.所有病例在病变部位、数目、大小、边界、内部结构、软组织改变及病理性骨

  1. Clinical analysis on the surgical treatment of periacetabular tumors%髋臼部位肿瘤手术治疗的临床分析

    Institute of Scientific and Technical Information of China (English)

    倪建法; 周幸; 周光新; 计忠伟; 胡斌; 陆萌; 吴苏稼; 施鑫

    2014-01-01

    discuss the methods, effects, and complications of surgical treatment of periacetabular tumors. Methods We retrospectively analyzed the clinical data of 36 cases of periacetabular tumor surgically treated in our depart-ment, including 21 males and 15 females, aged 15 to 64 (45.2 ±6.3) years.Among them, there were 8 cases of benign tumor (4 ca-ses of simple bone cyst, 1 case of desmoplastic fibromas, 1 case of osteofibrous dysplasia, and 2 cases of hemangioma) and 28 cases of malignant tumor (5 cases of osteosarcomas, 12 cases of chondrosarcomas, 2 cases of giant cell tumor of the bone, 1 case of malignant chondroblastoma, 2 cases of malignant fibrohistiocytoma, and 5 cases of metastatic tumor of the bone).The benign cases received sim-ple tumor resection plus bone graft and steel plate system internal fixation, while malignant cases underwent reconstruction by combined pedicle screw fixation system with bone cement. Results No patients died perioperatively and controllable complications occurred in 5 cases after operation.All the patients were followed up for 5 to 96 months except for 1 case of benign tumor.None of the benign cases experienced recurrence, and all of them achieved normal hip function.Lung metastases occurred in 10 malignant cases (4 cases of os-teosarcomas and 6 cases of chondrosarcomas) , who died of respiratory failure, and the other 18 remained tumor-free after surgery.Of the 2 patients with malignant fibrohistiocytoma, 1 died 2 years postoperatively and the other survived with tumor.Neither local recur-rence nor lung metastasis was found in the patients with chordoma and malignant chondroblastoma till the end of follow-up.The 5 pa-tients with metastases died within 3 years after operation.At 3 months after surgery, the Harris scores after total hip replacement were >90 in the 7 benign cases, 70-79 in 9 malignant cases, and <70 in the other 19 malignant cases. Conclusion For the treatment of malig-nant tumors, reconstruction by combined pedicle screw

  2. 单中心肩胛骨肿瘤166例流行病学分析%An one-center epidemiological analysis of scapular tumors:166 cases report

    Institute of Scientific and Technical Information of China (English)

    高明; 张清; 徐立辉; 刘巍峰; 牛晓辉

    2015-01-01

    133 cases of primary tumors and 33 cases metastatic tumors. One hundred and eleven cases of them were male patients and 55 were female, and the ratio of males to females was 2.02 : 1. Age of onset varied from 5 to 80 years. There were 74 cases ( 44.58% ) of primary malignancy, 33 cases ( 19.88% ) of metastatic malignancy, 18 cases ( 10.84% ) of intermediate tumors and 41 cases ( 24.70% ) of benign tumors. The median age of primary malignancy was 31 years old ( range: 6-80 years ). The most common tumor types were chondrosarcoma, Ewing’s sarcoma and osteosarcoma. The median age of metastatic malignancy was 54 years ( range: 36-79 years ). The most common primary tumor types were lung cancer, breast cancer and prostate cancer. The median age of intermediate tumors was 18 years ( range: 5-62 years ). The most common tumor types were chondroblastoma, Langerhans cell histiocytosis and giant cell tumors. The median age of benign tumors was 25 years ( range: 10-62 years ). The most common tumor types were osteochondroma, enchondroma and simple bone cyst.Conclusions Malignant tumors are more common than the benign ones among scapular tumors. Metastatic tumors, chondrosarcoma, Ewing’s sarcoma and osteosarcoma are common malignant types, and osteochondroma is the most common benign tumors located in scapula.

  3. 锁定加压接骨板治疗股骨远端良性骨肿瘤刮除植骨术后早期病理骨折的临床初步探讨%The clinical efficacy of locking compression plate in early stage pathological fracture after curettage and grafting of the benign distal femur tumor

    Institute of Scientific and Technical Information of China (English)

    赵军; 杨蕴; 韩秀鑫; 张瑾; 廖智超; 杨吉龙; 邢汝维

    2012-01-01

    [Objective] To determine the clinical efficacy of locking compression plate in early stage pathological fracture after curettage and grafting of the benign distal femur tumor. [ Method ] Our department had treated 11 patients with early stage pathological fracture after curettage and grafting of the benign distal femur tumor, including 7 male and 4 female patients with the average age of 42. 7 years whose ages ranging from 16 to 61 years. The types of primary tumor in these patients were;2 patients with enchondroma, 1 with primary osteoclastoma,4 with chondroblastoma,3 with chondromyxoid fibroma of bone, 1 with eosinophilic granulomatosis. The times between the curettage and grafting to the fracture were from 21 to 36 days with the average time of 22. 3 days. The types of distal femur fracture in these patients were all type Al who were treated with evenly locking compression plate, internal fixation and bone grafting. [ Result ] One patient in 11 had infection in wound, another had blood clots in popliteal vein after surgery which improved within treatment. No patients had complications as immunological rejection, incorrect reduction of fracture, loosening and rupture of internal fixation, refracture, tumor recurrence and secondary arthritis. The follow-up time were 12 to 61 months with average follow-up time of 34. 4 months. Their knee joint functions all returned to normal range of activity including the flexion of 120°to 135°and the hyperextension of 0°to 5° ,MSTS lower extremity scores were 28 -30 points with average scores of 28.9 points. [Conclusion]The internal fixation of locking compression plate has good mechanical property with fixedness and reliableness which contributes to the healing of facture and the restoration of tumor cavity grafting. Besides, it could assist functional practice in early stage to restore knee joint function. The locking compression plate is a potent internal fixation for early stage pathological fracture after curettage and

  4. 前外侧和外侧联合入路的股骨颈肿瘤刮除植骨及内固定术%Surgical technique of combined anterior-lateral and lateral approach in the management of bone tumor of femoral neck

    Institute of Scientific and Technical Information of China (English)

    伦登兴; 胡永成; 黄洪超; 夏群; 苗军; 于金虎

    2011-01-01

    Objective To explore surgical procedure of combined anterior-lateral and lateral approach for the treatment of bone tumors of femoral neck. Methods Forty patients with bone tumors of femoral neck treated in Tianjin Hospital were included from July 2005 to August 2009. Of the patients, 12 who were treated with curettage and bone graft through combined anterior-lateral and lateral incision were analyzed in this study. There were 7 males and 5 females with an average age of 34 years ranging from 17 to 68 years. 4 patients were diagnosed as chondroblastoma, 2 giant cell tumor, 3 fibrous dysplasia, and 3 single bone cysts. 7 patients suffered from pathologic fractures, and 5 had presented thin cortical bone because of tumor involvement. There were 1 tumor located in H1 zone, 4 in H2 zone and 7 in H1,2 zone according to ISOLS femoral neck classification. All patients were treated by curettage and bone graft via anterior-lateral approach, 10 cases underwent internal fixation with anatomical plate, and 2 cases with canulated screws with lateral approach. Results The follow-up time ranged from 10 to 68 months with an average of 35 months.Pain disappeared in all patients, and there were not recurrence of tumor, pathologic fractures and avascular necrosis. One case had complained of lateral femoral skin numbness which may be caused by injures of femoral lateral nerves. One case had difficulties in the valgus of hip joint. The mean MSTS score was 29.2 points ranging from 27 to 30 points. Conclusion Anterior approaches of "SP" incision is helpful to thorough curettage which decrease the risk of recurrence due to good visualization and intemal fixation is easy to perform via lateral approaches. The result suggested that combined anterior-lateral "SP" and lateral incision is liable option in treatment of bone tumors of femoral neck.%目的 探讨前外侧和外侧联合入路肿瘤刮除植骨重建治疗股骨颈骨肿瘤的疗效.方法 2005年7月至2009年8月采用前外侧