WorldWideScience

Sample records for choix public par

  1. Choix Cruciaux

    International Development Research Centre (IDRC) Digital Library (Canada)

    Il propose une solution efficace à ce problème de santé grâce à un partenariat entre l'industrie pharmaceutique (avec ses compétences dans la mise au point de médicaments) et le secteur public (avec sa connaissance des études in situ et de la recherche fondamentale en biologie). ˜ Il constitue une bonne passerelle ...

  2. Faillite de l'Etat et administration de l'espace public politique par les ...

    African Journals Online (AJOL)

    seriane.camara

    16 sept. 2010 ... rôle de premier plan dans l'espace public politique. Il apparait que ..... diffusées par les médias internationaux, qui ont eu pour effet de présenter une image ..... elle favorise un questionnement de la définition habermassienne de l'espace public perçu .... souveraineté de l'Etat ivoirien, lui refusait ce droit.

  3. Vote par sondage uniforme incorruptible

    OpenAIRE

    Blanchard , Nicolas

    2016-01-01

    International audience; Introduit en 2012 par David Chaum, le vote par sondage uniforme (random-sample voting) est un protocole de vote basé sur un choix d'une sous-population représentative , permettant de limiter les coûts tout en ayant de nombreux avantages, principalement lorsqu'il est couplé a d'autres techniques comme ThreeBallot. Nous analysons un problème de corruptibilité potentielle où les votants peuvent vendre leur vote au plus offrant et proposons une variation du protocole reméd...

  4. Les choix des créatrices de bande dessinée

    Directory of Open Access Journals (Sweden)

    Sylvain Rhéault

    2012-11-01

    Full Text Available Quels choix s’offrent aux femmes qui optent pour une carrière de bédéiste ? Il y a d’abord le modèle de la BD traditionnelle, établi par des pionniers comme Hergé dans la première moitié du XXe siècle et qui s’adresse à un lectorat essentiellement masculin. Le modèle de la BD alternative, quant à lui, favorise la recherche esthétique au détriment des ventes. Enfin, avec le modèle du shōjō manga, venu du Japon, des femmes créent des BD pour des femmes à propos de femmes.

  5. Facteurs environnementaux de proximité et choix résidentiels

    Directory of Open Access Journals (Sweden)

    Sandrine Gueymard

    2006-05-01

    Full Text Available Pendant longtemps marginalisée au sein des critères de choix résidentiels, la qualité de l’environnement s’affirme aujourd’hui dans les sondages d’opinion comme un nouveau facteur d’arbitrage pour les ménages. Dans un contexte de sensibilité croissante des ménages à la qualité de vie et de territorialisation de l’action publique notamment en matière d’environnement, la mesure précise de l’impact des aménités environnementales devient une question cruciale pour les acteurs territoriaux, notamment en milieu urbain. Cet article vise à alimenter la réflexion sur la valorisation des facteurs environnementaux de proximité par l’analyse des préférences résidentielles, des usages, perceptions et représentations que les ménages développent à leur contact en s’appuyant précisément sur un travail de recherche exploratoire dédié à un attribut environnemental spécifique, caractéristique des milieux urbains : les espaces verts.According to opinions pools, environmental quality appears nowadays as a deciding factor in residential choices wheareas it has been marginalized for a long time. In this background of households growing sensitivity for life quality and changes in public action in particular concerning environment, the precise measurement of environmental amenities is now a crucial issue for local decidors, specially in urban areas. The purpose of this paper is to feed reflection about valorisation of environmental factors of proximity by an analyse of residential preferences, uses, perceptions and representations developped by houselhold to them contact. We will develop this subject, basing ourselves on a exploratory research work focused on a particular environmental factor, which is characteristic of urban areas: green spaces.

  6. Choix de l\\'ondelette analysante et classification des signaux ...

    African Journals Online (AJOL)

    Dans le souci de répondre au choix délicat du type d\\'ondelette et de son ordre et afin de mettre plus en relief l\\'analyse des signaux PCG (normaux et pathologiques) en fonction de l\\'importance de leurs ... Choice of the analysing ondelette and classification of signals phonocardiogram s according to the added murmurs

  7. Choix, valeurs, théorisation

    Directory of Open Access Journals (Sweden)

    George Brunel

    2009-10-01

    Full Text Available Georges Brunel, vous êtes conservateur général et avez assumé entre la direction des études de restauration à l’Ecole nationale du patrimoine. Vous avez collaboré à l’édition française de Cesare Brandi, Théorie de la restauration, publiée en 2001. La traduction est précédée d’une introduction dont vous êtes l’auteur. Quelle a été l’occasion de cette publication ?S’il y a quelque chose qui doive étonner, c’est qu’elle ait eu lieu si tard. Les écrits de Brandi sur la restauration, comme ceux de...

  8. Resultats principaux & recommandations: Le renforcement des Comités de Paix Locaux - Faciliter les débats des parties prenantes sur les choix stratégiques impliqués dans la justice transitionnelle au Burundi et en RDC

    NARCIS (Netherlands)

    Leeuwen, M. van; Nindorera, J.; Nzweve, J.-L.; Uffelen, G.-J. van; Corbijn, C.; Boer, Sanne de

    2016-01-01

    Les Comités de Paix Locaux (CPLs) sont devenus une importante stratégie d’organisations de développement pour promouvoir la justice transitionnelle dans des contextes touchés par des conflits. Dans la pratique, travailler avec les CPLs implique plusieurs choix stratégiques, y compris sur (1) la

  9. Le recours aux catégories dans la gestion du choix au cours d’un repas au restaurant

    Directory of Open Access Journals (Sweden)

    Hugol-Gential Clémentine

    2012-07-01

    Full Text Available Ce travail, ancré dans le champ de l’Analyse Conversationnelle (Sacks, 1992, s’intéresse à une question centrale à laquelle les clients sont perpétuellement confrontés lors de la prise d’un repas au restaurant : le choix. Plus précisément, nous nous intéressons à son caractère situé et à son déploiement en interaction en nous basant sur un corpus audiovisuel collecté en situation « naturelle » de production, lors de repas au restaurant, afin d’étudier la parole-en-interaction telle qu’elle est localement produite et organisée par les participants (Heath, Hindmarsch & Luff, 2010. Après avoir exposé le lien entre identité et alimentation et la notion de catégorisation telle qu’elle a été développée en Analyse Conversationnelle, nous proposerons deux analyses de séquences de prise de commande pendant lesquelles les choix des clients sont discutés et négociés avec le sommelier ou le serveur. Grâce à des analyses séquentielles basées sur des transcriptions fines, nous soulignerons que les participants à l’interaction manifestent de façon reconnaissable qui ils sont (clients experts, non experts, habitués... afin d’organiser de façon intelligible leurs actions et de permettre à leurs partenaires de s’y ajuster. Nous analyserons finement les catégories utilisées par les participants, et nous décrirons les différents procédés mobilisés afin d’organiser et d’orienter la prise de commande. Ainsi, dans un premier extrait, nous verrons que les clients s’orientent, tout d’abord, vers l’exhibition de leur propre identité, tandis que dans un deuxième extrait, c’est le plat à la carte qui fait l’objet d’une première catégorisation. L’ensemble de ce travail nous permettra de montrer que les catégories sont structurantes pour l’organisation du choix et que leur déploiement séquentiel au cours de l’interaction est constitutif des affiliations ou des désaffiliations lors

  10. Faillite de l'Etat et administration de l'espace public politique par les ...

    African Journals Online (AJOL)

    En Côte d'Ivoire, depuis le déclenchement de la guerre en 2002, des mouvements de jeunes regroupés dans ce qu'il est convenu d'appeler « jeunes patriotes » sont apparus. Ils ont joué et continuent de jouer un rôle de premier plan dans l'espace public politique. Il apparait que leur irruption dans cet espace découle de ...

  11. LE CHOIX STRATEGIQUE ET L'AVANTAGE CONCURRENTIEL DE L’ENTREPRISE

    OpenAIRE

    CHEMMA, Nawel

    2011-01-01

    Cette étude vise à montrer comment le bon choix de la stratégie permet à l’entreprise l’acquisition et le développement d’un avantage concurrentiel distinctif et durable sur l’ensemble des concurrents. Et on a expliqué que le choix de la stratégie nécessite à l’entreprise de passer sur des étapes stratégiques qui fournissent les guides principales pour faire des choix stratégiques irréversibles. Nous avons consacré la partie pratique pour une étude de cas dans une entreprise Al...

  12. Le choix du périurbain à Québec : nature et biographie résidentielle

    Directory of Open Access Journals (Sweden)

    Andrée Fortin

    2009-01-01

    Full Text Available À l’heure des changements climatiques et du vieillissement de la population québécoise, nous nous sommes interrogées sur ce qui attire et/ou retient des résidents dans le périurbain, souvent au prix de longs déplacements quotidiens pour le travail ou les emplettes. Comme dans certains secteurs périurbains le prix des résidences est très élevé, le choix résidentiel ne se réduit pas à des considérations d’ordre économique. Nous analysons ici une des composantes essentielles du milieu et qui en fait aux yeux de plusieurs un « milieu sain » : la proximité de la nature. En quoi cela constitue-t-il un attrait pour les résidents ? Est-ce parce qu’il permet un mode de vie associé à des activités de plein air, ou plutôt un milieu « naturel » associé aux grands espaces ? Quel rapport les résidents du périurbain ont-il avec la nature qui les entoure ? Dans le cadre d’une recherche qualitative sur l’étalement urbain, nous avons interrogé 132 résidents de six secteurs périurbains de l’agglomération de Québec (Canada, associés autrefois à la villégiature ou à l’agriculture. Les entretiens semi-dirigés portaient sur le choix résidentiel, les représentations de la ville, de la banlieue, de la campagne et du village, les lieux fréquentés dans l’agglomération et le rapport à l’automobile. Il apparaît que les éléments recherchés dans le milieu de vie par plusieurs répondants sont ceux qu’ils ont connus dans leur enfance, dans des banlieues pavillonnaires de première couronne (c’est-à-dire édifiées dans les années 1950 et 1960 ou des régions rurales, dont ils sont majoritairement issus. C’est ainsi que la biographie personnelle semble influencer le choix résidentiel. Pour vivre près de la nature, ils seraient prêts à s’éloigner davantage de la ville qu’ils caractérisent essentiellement par la pollution et le béton. La dépendance à l’automobile que ce mode de vie entra

  13. Action et choix des femmes au Chili | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Ce projet part de l'hypothèse que les obstacles subjectifs sont vraisemblablement plus contraignants pour la participation des femmes que ceux dont il est question dans les recherches classiques sur la gouvernance démocratique et les droits des femmes. Par une analyse culturelle, les chercheurs tenteront de comprendre ...

  14. Poder público e sindicato: um olhar à privatização das centrais elétricas do Pará Public power and syndicalism: looking to the privatization of the electric centrals from Pará

    Directory of Open Access Journals (Sweden)

    Andréa Bittencourt Pires Chaves

    2009-04-01

    Full Text Available Este estudo aborda o sindicalismo dos Urbanitários diante do programa brasileiro de privatização. Buscando compreender este processo, discute o contexto neoliberal que implementa as privatizações no Brasil, as falácias que envolvem os números apresentados pelo governo brasileiro em relação aos benefícios provocados aos cofres públicos com a venda de estatais e o papel de estatais estrangeiras na compra de estatais brasileiras para então olhar a resistência do Sindicato dos Urbanitários e as ações do poder público estadual responsáveis pela demissão de trabalhadores para sanear a empresa no processo de privatização das Centrais Elétricas do Pará. A construção do texto foi realizada a partir de levantamento bibliográfico e documental, assim como entrevistas com lideranças sindicais. Palavras-chave: Trabalho. Sindicato. Privatização. This study approaches the Urbanists syndicalism in front of the Brazilian program of privatizations. In search of understanding this process, the discussion focuses on the neoliberal context which implements the Brazilian privatizations, the lies involved in the numbers presented by the government about the benefits to the public safes with the selling of State companies and the role of foreign State companies in this buying process, so that we can see the Urbanists Syndicalism resistance and also the actions of the Public State power responsible by the workers unemployment to make provisions for the companies inside the privatization process of the Electrical Centrals from Pará. The text was written trough biographic and documental research, and also by interviews with Syndicalism’s leaderships. Keywords: Work. Syndicalism. Privatization.

  15. Atouts, limites et exploitations potentielles du choix fourni dans les logiciels de langue

    Directory of Open Access Journals (Sweden)

    Emmanuelle Duchiron

    2005-09-01

    Full Text Available Deux constats sont à l'origine de notre étude. Premièrement, la majorité des activités proposées dans les didacticiels de langue sont construites à partir d'exercices à choix fourni. Deuxièmement, le peu de littérature qui existe sur le choix fourni date des années 70 et 80, époque depuis laquelle les conceptions de l'enseignement / apprentissage des langues ont nettement évolué, les Technologies de l'Information et de la Communication (TIC y occupant une place de plus en plus importante. Nous pouvons donc nous demander sur quelles théories s'appuie la conception des exercices proposés dans les didacticiels de langue actuels. Nous avons tenté d'établir un vade-mecum reprenant neuf points essentiels concernant la conception d'un didacticiel de langue à partir de l'analyse d'exercices à choix fourni d'une sélection de huit didacticiels.

  16. Dentistry and food safety – the oral health of food handlers at a public hospital in the city of Belém, Pará

    Directory of Open Access Journals (Sweden)

    Elaine Beatriz Teixeira Ramalho

    2008-01-01

    Full Text Available Objective: This research evaluated the oral health of 40 food handlers in the Nutrition and Diet Unit of a public hospital in Belém-Pará. Methods: Interview and intra-oral examination of the subjects.Results: The results showed a high prevalence of tooth decay and periodontal disease, in addition to a low level of education and motivation as regards oral health care in the studied sample.Conclusion: The authors concluded that oral health care and education should be included in publications for and training of food handlers,since oral health promotion would benefit these workers directly, by increasing their quality of life, and indirectly benefit the entirecommunity that consumes the food prepared by them. The results and conclusions of this work should encourage the development of oralhealth care promotion programmers as regards this particular group of employees, the food handlers.

  17. Paraplégie compliquant une plaie abdominale antérieure par arme blanche

    Science.gov (United States)

    Elahmadi, Brahim; Awab, Almahdi; El Moussaoui, Rachid; El Hijri, Ahmed; Azzouzi, Abderrahim; Alilou, Mustapha

    2015-01-01

    Les traumatismes médullaires sont des complications rares des plaies abdominales antérieures par arme blanche. Son diagnostic est difficile parfois retardé. L'imagerie par résonance magnétique reste l'examen de choix. Le traitement dépend du tableau clinique et de la gravité de la souffrance médullaire. Le pronostic est corrélé à l’étendue et à la nature de la lésion médullaire. Nous rapportons un cas exceptionnel d'un traumatisme médullaire chez une patiente victime d'une plaie abdominale antérieure par arme blanche. PMID:25995808

  18. [Quality of life of hemodialysis patients in a Brazilian Public Hospital in Belém - Pará].

    Science.gov (United States)

    Silveira, Cíntia Botelho; Pantoja, Ivaneida Kzarina Olaia Ribeiro; Silva, Allan Roberto Marques; Azevedo, Rômulo Nina de; Sá, Nayara Bandeira de; Turiel, Marck Gregório Pereira; Nunes, Mário Barbosa Guedes

    2010-03-01

    End-stage chronic kidney disease (CKD) requiring dialysis affects the quality of life sometimes more severely than other chronic diseases, such as rheumatoid arthritis, heart failure, coronary artery disease, and chronic obstructive pulmonary disease, exerting a negative effect on the energy and vitality levels, limiting social interactions, and hindering psychic health. To evaluate the quality of life of patients with CKD on hemodialysis in a public Brazilian Amazonian hospital. Data were collected through interview based on the Brazilian version of the SF-36 questionnaire. The study was conducted on 50 patients (mean age, 48 ± 16 years; mean hemodialysis time, 3 ± 2.9 years). The most affected domain was role limitations due to physical health, with a mean score of 36 ± 36, and 58% of the patients in the lowest quartile, while mental health and social functioning were relatively preserved, with most patients in the highest quartile. Men obtained poorer scores than women did for role limitations due to physical health and vitality. Age correlated negatively with physical functioning. Patients on hemodialysis for more than one year had better scores in the social functioning domain, with a positive correlation between dialysis time and physical functioning. The domains assessed were globally impaired in the population studied, especially regarding role limitations due to physical health, suggesting that chronic disease with prolonged treatment has a negative influence on those domains.

  19. Le live-blogging : les figures co-construites de l’information et du public participant. La couverture de l’affaire DSK par lemonde.fr.

    Directory of Open Access Journals (Sweden)

    Nathalie Pignard-Cheynel

    2015-11-01

    Full Text Available Cette étude se propose d’analyser la participation des lecteurs-contributeurs à travers un dispositif spécifique, celui du live blogging, ou couverture en ligne et en direct sur le web d’un événement. Ce travail porte spécifiquement sur le live réalisé par lemonde.fr durant « l’affaire DSK » en mai 2011. Nous conduisons une analyse sur un corpus relatif aux premières 24 heures (sur 40 de cette couverture et composé de deux documents : le flux du live (376 posts tous locuteurs confondus et l’ensemble des messages soumis par les internautes (environ 8000 posts dont une infime partie seulement a été publiée (1%. L’analyse comparée des deux facettes de cette participation et des éléments méta-descriptifs relatifs au dispositif nous conduit à analyser la place de la parole ordinaire des internautes dans la production journalistique en interrogeant : 1 le processus de modération/filtrage effectué par les journalistes et la projection d’une représentation normative de la figure de l’internaute participant et 2 l’émergence d’une posture énonciative collective chez les internautes, prémisse d’une forme de « public » du live. Notre démarche qualita- tive a consisté à identifier manuellement l’ensemble des contributions des internautes en fonction de leur registre d’expression, en distinguant notamment les questions/demandes d’information, les opinions/commentaires personnels et les apports d’information. L’analyse a permis d’éclairer les ressorts de la participation profane en soulignant l’écart entre les messages soumis par les internautes et ceux publiés par les journalistes (révélateur de la modération éditoriale et donc la faible représentativité des contributions publiées sur le live. Globalement, les journalistes survalorisent les apports d’informations et délaissent presque systématiquement les messages de commentaires et opinions

  20. Offrir un choix aux agriculteurs pauvres: Harsha de Silva (Sri Lanka ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ans de nombreux pays en développement, les téléphones mobiles permettent aux pauvres de profiter des avantages des technologies de l'information et de la communication (TIC). Des travaux de recherche appuyés par le CRDI et dirigés par Learning Initiatives on Reforms for Network Economies (LIRNEasia), ...

  1. Offrir un choix aux agriculteurs pauvres: Harsha de Silva (Sri Lanka ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Des travaux de recherche appuyés par le CRDI et dirigés par Learning Initiatives on Reforms for Network Economies (LIRNEasia), à Colombo, au Sri Lanka, ont entre autres pour but de trouver des façons d'utiliser la téléphonie mobile et les technologies connexes pour améliorer les conditions de vie des pauvres. L'un des ...

  2. The equity of the initial allocation of the greenhouse gases releases permits to firms: an approach of the public choice by the moral philosophy and the economic analysis; L'equite de l'allocation initiale de permis d'emission negociables de gaz a effet de serre a des entreprises: un eclairage du choix public par la philosophie morale et l'analyse economique

    Energy Technology Data Exchange (ETDEWEB)

    Leseur, A

    2004-10-15

    In order to fight against the climatic change, the European directive 87/2003 provides for 2005 the adoption of a European market of negotiable releases permits but entrusts each state with choosing the method of permits allocation to the concerned domestic firms. Underwriting the reaching of the aim of pollution abatement in minimizing the global costs developed, the permits market is an economical tool of environmental policy chose for this double efficiency. But on which criteria determine the initial allocation? One of the most pertinent referents is the equity. What are the requirements for this in this situation? Seizing on this question, the thesis considers the contribution that can bring the moral and political philosophy, in particular the theories of the distributive justice, taking into account of two important aspects of the problem: 1)the property to distribute has particular characteristics, particularly the negotiability; 2)the attributing agents are firms and not the physical persons. In the first part, the thesis reveals, via the economical analysis, the operation of a permit competitive market and identifies the stakes, both at the pollution decision level than of the firms production in various contexts of market, and at those of the input or output decisions. In the second part, this work deals with the justice theories. The approach consists at first to establish their relevance showing that a firm can be considered as a moral entity, and be subject of duties and rights. Then, the question is to adapt the theories argumentation to this entity. This work emphasizes particularly the idea of a right to the chances equality for the competitiveness. It is then in the tension between this right and the duty to comply with the environmental policy that is found the equitable allocation. (O.M.)

  3. The equity of the initial allocation of the greenhouse gases releases permits to firms: an approach of the public choice by the moral philosophy and the economic analysis; L'equite de l'allocation initiale de permis d'emission negociables de gaz a effet de serre a des entreprises: un eclairage du choix public par la philosophie morale et l'analyse economique

    Energy Technology Data Exchange (ETDEWEB)

    Leseur, A

    2004-10-15

    In order to fight against the climatic change, the European directive 87/2003 provides for 2005 the adoption of a European market of negotiable releases permits but entrusts each state with choosing the method of permits allocation to the concerned domestic firms. Underwriting the reaching of the aim of pollution abatement in minimizing the global costs developed, the permits market is an economical tool of environmental policy chose for this double efficiency. But on which criteria determine the initial allocation? One of the most pertinent referents is the equity. What are the requirements for this in this situation? Seizing on this question, the thesis considers the contribution that can bring the moral and political philosophy, in particular the theories of the distributive justice, taking into account of two important aspects of the problem: 1)the property to distribute has particular characteristics, particularly the negotiability; 2)the attributing agents are firms and not the physical persons. In the first part, the thesis reveals, via the economical analysis, the operation of a permit competitive market and identifies the stakes, both at the pollution decision level than of the firms production in various contexts of market, and at those of the input or output decisions. In the second part, this work deals with the justice theories. The approach consists at first to establish their relevance showing that a firm can be considered as a moral entity, and be subject of duties and rights. Then, the question is to adapt the theories argumentation to this entity. This work emphasizes particularly the idea of a right to the chances equality for the competitiveness. It is then in the tension between this right and the duty to comply with the environmental policy that is found the equitable allocation. (O.M.)

  4. Pauvreté, durabilité et capacités de choix : Les paysans centrafricains peuvent-ils éviter le cercle vicieux ?

    Directory of Open Access Journals (Sweden)

    Benoît Lallau

    2004-10-01

    Full Text Available Cet article se propose d’approfondir la relation qui existe entre pauvreté et durabilité. Il se fonde sur des données issues d’enquêtes qualitatives menées par l’auteur en République Centrafricaine (RCA et sur un cadre conceptuel mettant les capacités de choix des individus au centre de l’analyse. Ces capacités sont limitées par la faiblesse des dotations en capital (monétaire, physique, naturel, humain, social, mais aussi par le manque d’opportunités rencontrées (marchés imparfaits, Etat défaillant, développeurs absents. Elles conduisent les individus à privilégier une gestion du risque à court terme, préjudiciable non seulement aux écosystèmes exploités, mais aussi à l’intégration économique, à la cohésion sociale et au développement humain. Un cercle vicieux se dessine alors, pauvreté et non durabilité se renforçant mutuellement.This article explores the relationship between poverty and sustainability. The study is based upon qualitative research conducted in CAR and a conceptual framework that emphasizes individuals' choice capabilities. These capabilities are limited by low endowment in capital (financial, physical, natural, human, and social, and by the lack of opportunities (imperfect markets, government failure, lack of development funds. Consequently, individuals tend to favor a short term risk management strategy which leads to non sustainability. This strategy impacts not only ecosystems, but also economic integration, social cohesion and human development. Poverty and non sustainability reinforce each other, illustrating a cumulative causation process.

  5. Choix culturels et orientations éducatives en Égypte. 1923-1952

    OpenAIRE

    Hassân, Hassan Muhammad

    2008-01-01

    Entre 1923 et 1952 étaient en concurrence, sur le terrain égyptien, plusieurs écoles de pensée, différant tant par leurs références que par leurs orientations, expression tout à la fois de dynamiques internes à la société égyptienne, de luttes sociales en cours et d'événements et de courants mondiaux. On ne peut réduire ces luttes à la seule dimension de la contradiction entre le Palais et les partis minoritaires, d'une part, et Mouvement national dirigé par le Wafd, d'autre part ; on ne peut...

  6. Qui représente qui ? Choix organisationnels, identités sociales et ...

    African Journals Online (AJOL)

    sulaiman.adebowale

    16 sept. 2006 ... recherche effectué au Sud-Cameroun depuis trois ans. .... secteur forestier sont passées par exemple en moins d'une décennie de 10 milliards de .... 1974, la Loi forestière n° 81/13 du 27 novembre 1981, et de nombreux pas-.

  7. suPAR

    DEFF Research Database (Denmark)

    Hodges, Gethin W; Bang, Casper N; Wachtell, Kristian

    2015-01-01

    The fundamental role of inflammation in cardiovascular disease (CVD) has prompted interest in numerous biomarkers that detect subclinical levels of inflammation. Soluble urokinase plasminogen activator receptor (suPAR) is a novel biomarker that correlates significantly with cardiovascular events ...... comprehensive review of suPAR in CVD and explore its function and usefulness in predicting cardiovascular events....

  8. Le choix du périurbain à Québec : nature et biographie résidentielle

    OpenAIRE

    Andrée Fortin; Andrée Fortin; Carole Després; Carole Després

    2009-01-01

    À l’heure des changements climatiques et du vieillissement de la population québécoise, nous nous sommes interrogées sur ce qui attire et/ou retient des résidents dans le périurbain, souvent au prix de longs déplacements quotidiens pour le travail ou les emplettes. Comme dans certains secteurs périurbains le prix des résidences est très élevé, le choix résidentiel ne se réduit pas à des considérations d’ordre économique. Nous analysons ici une des composantes essentielles du milieu et qui en ...

  9. Le choix du périurbain à Québec. Nature et biographie résidentielle

    OpenAIRE

    Fortin, Andrée; Després, Carole

    2011-01-01

    À l’heure des changements climatiques et du vieillissement de la population québécoise, nous nous sommes interrogées sur ce qui attire et/ou retient des résidents dans le périurbain, souvent au prix de longs déplacements quotidiens pour le travail ou les emplettes. Comme dans certains secteurs périurbains le prix des résidences est très élevé, le choix résidentiel ne se réduit pas à des considérations d’ordre économique. Nous analysons ici une des composantes essentielles du milieu et qui en ...

  10. Par Pond water balance

    International Nuclear Information System (INIS)

    Hiergesell, R.A.; Dixon, K.L.

    1996-06-01

    A water budget for the Par Pond hydrologic system was established in order to estimate the rate of groundwater influx to Par Pond. This estimate will be used in modeling exercises to predict Par Pond reservoir elevation and spillway discharge in the scenario where Savannah River water is no longer pumped and discharged into Par Pond. The principal of conservation of mass was used to develop the water budget, where water inflow was set equal to water outflow. Components of the water budget were identified, and the flux associated with each was determined. The water budget was considered balanced when inflow and outflow summed to zero. The results of this study suggest that Par Pond gains water from the groundwater system in the upper reaches of the reservoir, but looses water to the groundwater system near the dam. The rate of flux of groundwater from the water table aquifer into Par Pond was determined to be 13 cfs. The rate of flux from Par Pond to the water table aquifer near the dam was determined to be 7 cfs

  11. Choix de consultants extérieurs pour les projets secondaires

    CERN Document Server

    Yourassoff, L

    1998-01-01

    Les "petits projets" sont généralement inférieurs à 200 KCHF et techniquement peuvent être très variés: installation de monorails dans des structures existantes, construction de fosses transformateurs, d'abris de stockage, de murs de soutènement, modification ou extension de bâtiments existants. Il reste à constater qu'à l'origine la définition par l'utilisateur est souvent incomplète. Par manque de personnel et pour la réalisation de certains "petits projets" le Groupe Génie Civil doit faire appel à l'assistance d'architectes ou de bureaux d'ingénieurs spécialisés, tels que béton armé, charpente métallique, géotechnique. Le bureau d'ingénieurs mandaté doit pouvoir fournir, dans des délais généralement très courts, les prestations suivantes: mise au point et finalisation du projet en accord avec le CERN, établissement des plans d'exécution et textes de soumission, surveillance des travaux, expertises diverses. Un mode de règlement des honoraires adapté aux conditions du march�...

  12. FooPar

    DEFF Research Database (Denmark)

    Hargreaves, F. P.; Merkle, D.

    2013-01-01

    We present FooPar, an extension for highly efficient Parallel Computing in the multi-paradigm programming language Scala. Scala offers concise and clean syntax and integrates functional programming features. Our framework FooPar combines these features with parallel computing techniques. Foo......, results based on a empirical analysis on two supercomputers are given. We achieve close-to-optimal performance wrt. theoretical peak performance. Based on this result we conclude that FooPar allows programmers to fully access Scalas design features without suffering from performance drops when compared...

  13. CHOIX ET VALIDATION EXPERIMENTALE D'UN MODELE DE PYROLYSE POUR LE BOIS TRAITE PAR HAUTE TEMPERATURE : DE LA MICRO-PARTICULE AU BOIS MASSIF

    OpenAIRE

    Rousset , Patrick

    2004-01-01

    Pyrolysis carried out at relatively low temperatures in the range 200-280C produces a material with good dimensional stability and durability, with minimal effect on the mechanical properties because of its resilience. In spite of the large amount of research work injected into this topic, it is still a difficult task to identify the precise loss of product quality that has been incurred as a result of this process. This fact provides the motivation for a fundamental study that explains the m...

  14. Les reseaux de politique publique comme facteur d'influence du choix des instruments de politique energetique canadienne a des fins environnementales de 1993 a nos jours

    Science.gov (United States)

    Fathy El Dessouky, Naglaa

    l'agenda politique du pays. Notre projet de recherche, par le truchement de l'approche des reseaux de politique publique, s'attarde a decrire et a expliquer le processus de la formulation d'une politique particuliere, soit la politique energetique a des fins de protection de l'environnement, elaboree en 1993. Il s'agit de mettre en evidence les facteurs affectant le choix des instruments de ces politiques publiques dans leur contexte national. Ainsi, la question generale de cette recherche est: Comment les phases evolutives de la formation d'un reseau de politique, en l'occurrence le Conseil canadien de l'energie (CCE), menent a des caracteristiques particulieres a ce reseau; et comment celles-ci determinent-elles les types des instruments de politique publique choisis, particulierement ceux de la recente orientation des politiques energetiques canadiennes a des fins environnementales elaborees en 1993? Afin d'atteindre l'objectif de notre recherche, deux facteurs primordiaux sont utilises, soit la circulation de l'information et l'exercice du controle sur les ressources des acteurs. L'analyse des caracteristiques du reseau en fonction des liens forts et des liens faibles autant que la presence ou l'absence des trous structuraux nous permettent de bien identifier les positions des differents acteurs, etatiques et non etatiques, sur le plan de l'information et du controle, qui a leur tour, nous semble-t-il, constituent des facteurs affectant les types des instruments des politiques publiques choisis: instruments substantifs, qui indiquent le degre de l'intervention du gouvernement, et instruments proceduraux, qui mettent plutot l'accent sur le degre de l'influence du gouvernement sur les acteurs non etatiques. L'etude soutient que l'approche des reseaux se distingue notamment par son potentiel a expliquer l'interrelation relative entre idees, interets et institutions, ce qui a son tour est susceptible de permettre une meilleure comprehension des processus de l

  15. It's quicker "Par Avignon"!

    CERN Multimedia

    2005-01-01

    For a few years, the CERN Library has been receiving books from the University of Hanover sent via Avignon, at least that's what it says on the envelope. Such a detour would mean that parcels were travelling 720 km more than the distance separating Geneva and Hanover, which would be a very strange state of affairs. The explanation lies in a spelling mistake. The sender has been stamping parcels with a stamp that says "Par Avignon prioritaire" (first-class via Avignon) instead of "Par Avion prioritaire" (First Class Air Mail), a source of much amusement to the librarians!

  16. La pelade par plaques

    Science.gov (United States)

    Spano, Frank; Donovan, Jeff C.

    2015-01-01

    Résumé Objectif Présenter aux médecins de famille des renseignements de base pour faire comprendre l’épidémiologie, la pathogenèse, l’histologie et l’approche clinique au diagnostic de la pelade par plaques. Sources des données Une recension a été effectuée dans PubMed pour trouver des articles pertinents concernant la pathogenèse, le diagnostic et le pronostic de la pelade par plaques. Message principal La pelade par plaques est une forme de perte pileuse auto-immune dont la prévalence durant une vie est d’environ 2 %. Des antécédents personnels ou familiaux de troubles auto-immuns concomitants, comme le vitiligo ou une maladie de la thyroïde, peuvent être observés dans un petit sous-groupe de patients. Le diagnostic peut souvent être posé de manière clinique en se fondant sur la perte de cheveux non cicatricielle et circulaire caractéristique, accompagnée de cheveux en « point d’exclamation » en périphérie chez ceux dont le problème en est aux premiers stades. Le diagnostic des cas plus complexes ou des présentations inhabituelles peut être facilité par une biopsie et un examen histologique. Le pronostic varie largement et de mauvais résultats sont associés à une apparition à un âge précoce, une perte importante, la variante ophiasis, des changements aux ongles, des antécédents familiaux ou des troubles auto-immuns concomitants. Conclusion La pelade par plaques est une forme auto-immune de perte de cheveux périodiquement observée en soins primaires. Les médecins de famille sont bien placés pour identifier la pelade par plaques, déterminer la gravité de la maladie et poser le diagnostic différentiel approprié. De plus, ils sont en mesure de renseigner leurs patients à propos de l’évolution clinique de la maladie ainsi que du pronostic général selon le sous-type de patients.

  17. Impacto das remessas familiares e do programa Prospera em jovens de nível médio superior em Choix, Sinaloa, México

    OpenAIRE

    Pintor Sandoval, Renato; Peraza Noriega, Brianda Elena; Heredia Trasviña, Karen Olivia

    2017-01-01

    Objective: to establish the impact of family remittances from the United States and the "Prospera" welfare program for the high school student population in a community with high social exclusion and poverty in Sinaloa.Methodology: first, the population, economic and work activities in the community of Choix, Sinaloa were described. Then, the discussion on remittances and the beneficiary families of the Prospera program were characterized; finally, a survey was designed and applied to 114 hig...

  18. suPAR

    DEFF Research Database (Denmark)

    Eugen-Olsen, Jesper; Giamarellos-Bourboulis, Evangelos J

    2015-01-01

    Investigation of biomarkers that can promptly predict unfavourable outcome of critically illness is an emerging necessity taking into consideration the need for early intervention, the shortage of available beds in intensive care units and the considerable cost of hospitalisation. The most...... promising biomarker is soluble urokinase-type plasminogen activator receptor (suPAR). Three studies in large populations of critically ill patients and patients admitted to the emergency department have shown that concentrations >12ng/mL can safely predict unfavourable outcome. This review presents...

  19. Parálisis cerebral :

    OpenAIRE

    Cabrero Izquierdo, María del Carmen

    2012-01-01

    Se aborda el tema de la parálisis cerebral definiendo qué es, clasificando los tipos de parálisis dependiendo de la afectación y las características principales. Se explican algunos de sus tratamientos, se dan sistemas alternativos y/o aumentativos de comunicación para un alumno con PC (parálisis cerebral).

  20. Nuclear wastes management. 1. round table - geologic disposal as questioned by the public in concern; Gestion des dechets nucleaires. 1. table ronde le stockage geologique - la mise en question par les publics concernes

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    The law from December 30, 1991, precisely defines 3 axes of researches for the management of high level and long-lived radioactive wastes: separation/transmutation, surface storage and underground disposal. A global evaluation report about these researches is to be supplied in 2006 by the French government to the Parliament. A first synthesis of the knowledge gained after 14 years of research has led the national commission of the public debate (CNDP) to organize a national debate about the general options of management of high-level and long-lived radioactive wastes before the 2006 date line. The debate comprises 4 public hearings (September 2005: Bar-le-Duc, Saint-Dizier, Pont-du-Gard, Cherbourg), 12 round-tables (October and November 2005: Paris, Joinville, Caen, Nancy, Marseille), a synthesis meeting (December 2005, Dunkerque) and a closing meeting (January 2006, Lyon). This document is the synthesis of the debates of the last round table held at Paris. This meeting gathers representatives of the different actors of the nuclear industry, ministers, public authorities, non governmental organizations who argue the questions asked by peoples from the audience. The topics concern various aspects of waste management, like the quantity of wastes in concern, the reversibility of storages, the monitoring of waste facilities once closed down, the related costs, and the general safety questions about the suitability of the clay formation near the Bure site for the disposal of high-level and long-lived radioactive wastes. A second part of the meeting addresses some remarks about the information of the general public and the decision making process. Finally, five presentations (slides) are attached to these proceedings and treat of: the safety of the disposal in deep geologic formation; the management of spent fuels in Canada; the nuclear wastes R and D in Sweden; the researches and projects in Belgium for the geologic disposal of long-lived radioactive wastes; the results

  1. Nuclear wastes management. 1. round table - geologic disposal as questioned by the public in concern; Gestion des dechets nucleaires. 1. table ronde le stockage geologique - la mise en question par les publics concernes

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    The law from December 30, 1991, precisely defines 3 axes of researches for the management of high level and long-lived radioactive wastes: separation/transmutation, surface storage and underground disposal. A global evaluation report about these researches is to be supplied in 2006 by the French government to the Parliament. A first synthesis of the knowledge gained after 14 years of research has led the national commission of the public debate (CNDP) to organize a national debate about the general options of management of high-level and long-lived radioactive wastes before the 2006 date line. The debate comprises 4 public hearings (September 2005: Bar-le-Duc, Saint-Dizier, Pont-du-Gard, Cherbourg), 12 round-tables (October and November 2005: Paris, Joinville, Caen, Nancy, Marseille), a synthesis meeting (December 2005, Dunkerque) and a closing meeting (January 2006, Lyon). This document is the synthesis of the debates of the last round table held at Paris. This meeting gathers representatives of the different actors of the nuclear industry, ministers, public authorities, non governmental organizations who argue the questions asked by peoples from the audience. The topics concern various aspects of waste management, like the quantity of wastes in concern, the reversibility of storages, the monitoring of waste facilities once closed down, the related costs, and the general safety questions about the suitability of the clay formation near the Bure site for the disposal of high-level and long-lived radioactive wastes. A second part of the meeting addresses some remarks about the information of the general public and the decision making process. Finally, five presentations (slides) are attached to these proceedings and treat of: the safety of the disposal in deep geologic formation; the management of spent fuels in Canada; the nuclear wastes R and D in Sweden; the researches and projects in Belgium for the geologic disposal of long-lived radioactive wastes; the results

  2. Propaganda de medicamentos para grande público: parâmetros conceituais de uma prática produtora de risco Drug advertising to the general public: conceptual parameters of a risk producer practice

    Directory of Open Access Journals (Sweden)

    Álvaro César Nascimento

    2010-11-01

    Full Text Available Este artigo analisa alguns conceitos relativos a marketing, propaganda, medicamento, regulação e manipulação, discutindo parâmetros éticos e de vigilância sanitária relativos à prática da propaganda de medicamentos para o grande público. O foco deste trabalho é a análise das contradições, desde o ponto de vista conceitual, da prática da propaganda farmacêutica como instrumento de elevação das vendas e conquista de mercados versus a política de uso racional de medicamentos. Estudos acadêmicos e a monitoração da propaganda farmacêutica realizada pela Agência Nacional de Vigilância Sanitária demonstram que os conteúdos das peças publicitárias de medicamentos direcionadas ao grande público superestimam as qualidades do produto, enaltecem quase exclusivamente seus benefícios, colocando-os em uma posição central no processo terapêutico; e omitem os riscos inerentes à sua utilização e exageram suas qualidades, às vezes duvidosas. Mais que se debruçar sobre propostas reguladoras que objetivariam criar constrangimentos a esta prática, este artigo discute a impossibilidade, considerando-se os interesses da saúde pública, da convivência de interesses tão díspares quanto os do marketing - que busca sempre expandir mercados - e das políticas de uso correto, racional e seguro de medicamentos.This article analyzes some concepts relating to marketing, advertising, medications, regulation and manipulation. It discusses ethical and health surveillance parameters of drugs advertising for the general public. The focus of this work is the analysis of contradictions from a conceptual point of view between the practice of pharmaceutical advertising as a tool for the increase of sales and the conquest of markets versus the policy of rational use of medicines. Academic studies and monitoring of drugs advertising conducted by the National Health Surveillance Agency show that the contents of the advertising pieces oriented

  3. Qualidade de vida de pacientes em hemodiálise em um hospital público de Belém - Pará Quality of life of hemodialysis patients in a Brazilian Public Hospital in Belém - Pará

    Directory of Open Access Journals (Sweden)

    Cíntia Botelho Silveira

    2010-03-01

    Full Text Available INTRODUÇÃO: A doença renal crônica (DRC dialítica afeta a qualidade de vida do paciente, por vezes de maneira mais intensa que outras doenças crônicas, como artrite reumatóide, insuficiência cardíaca, doença arterial coronariana e doença pulmonar obstrutiva crônica, exercendo efeito negativo sobre os níveis de energia e vitalidade, limitando as interações sociais e prejudicando a saúde psíquica. OBJETIVO: Avaliar a qualidade de vida de pacientes com IRC em programa de hemodiálise ambulatorial em um hospital público de Belém - Pará. MÉTODO: O estudo baseou-se em dados coletados em entrevista, utilizando a versão brasileira do questionário SF-36. Foram avaliados 50 pacientes, com idade média de 48 ± 16 anos e tempo médio em hemodiálise de 3 ± 2,9 anos, 62% do sexo masculino. RESULTADOS: A dimensão mais afetada foi relativa aos aspectos físicos, com pontuação média de 36 ± 36 e 58% dos pacientes no quartil mais baixo, enquanto saúde mental e aspectos sociais demonstraram relativa preservação, com a maioria dos pacientes alocados no quartil mais elevado. A população masculina apresentou piores escores que a feminina quanto a aspectos físicos e vitalidade. A idade correlacionou-se negativamente com a capacidade funcional. Os pacientes em hemodiálise há mais de um ano apresentaram melhores níveis no domínio aspectos sociais e houve correlação positiva entre o tempo em diálise e a capacidade funcional. CONCLUSÃO: Os domínios analisados estiveram globalmente comprometidos na população estudada, em especial com relação aos aspectos físicos, sugerindo a influência negativa da presença de doença crônica, com tratamento prolongado, sobre esses âmbitos.INTRODUCTION: End-stage chronic kidney disease (CKD requiring dialysis affects the quality of life sometimes more severely than other chronic diseases, such as rheumatoid arthritis, heart failure, coronary artery disease, and chronic obstructive

  4. Cascade: a Knowledge-Based System Supporting Shoe Depths Selection and Casing Design CASCADE : un système à base de connaissances pour l'aide au choix de la profondeur des sabots et à la conception du tubage

    Directory of Open Access Journals (Sweden)

    Sansone A.

    2006-11-01

    meet all the requirements and minimize cost is not a trivial task. The choice of the expert systems technology exploited for the system development is related to the following topics :(a An expert system can combine several different skills. (b It guarantees easy and modular expanclibility with the acquisition of new experience. (c Moreover, new experience must be taken into account in order to continuously increase the quality of the results. (d Available data come from many sources, and all have to be considered when choosing the shoe depths' and casing's geometrical and mechanical characteristics. (e An expert system can explicitly represent both domain and strategical knowledge that can easily be modified, added or expunged. It can also give the user a feedback on its own behaviour, and it can also be used as a training tool. The benefits for the final user are:(a An efficient, integrated environment providing the tools the drilling engineer needs to work with. (b Greater accuracy. (c Access and assessment of knowledge and procedures regarding this matter. (d Interactive, user friendly interface. CASCADE est un système d'aide à la conception du tubage et au choix des sabots pour les puits d'exploration et de production. Ce système expert est une partie du projet ADIS (Advanced Drilling Information System, Système d'Information Avancé pour le Forage développé en commun par trois sociétés du groupe ENI : AGIP, ENIDATA et SAIPEM. Le but d'ADIS est de fournir des outils informatiques d'ingénierie de forage pour la planification et le suivi des opérations, utilisables aussi bien sur le site de forage que dans les bureaux. Ces outils devront également superviser les opérations en temps réel et émettre des diagnostics. Pour les tâches de suivi en temps réel, l'équipe de projet d'ADIS a mis au point des systèmes permettant la communication par satellite entre les appareils de forage et la base, ainsi que des systèmes experts de supervision pour l

  5. Publicity.

    Science.gov (United States)

    Chisholm, Joan

    Publicity for preschool cooperatives is described. Publicity helps produce financial support for preschool cooperatives. It may take the form of posters, brochures, newsletters, open house, newspaper coverage, and radio and television. Word of mouth and general good will in the community are the best avenues of publicity that a cooperative nursery…

  6. ETUDES ANALYTIQUES : Détection des OGM : du libre choix des consommateurs aux études de biovigilance

    Directory of Open Access Journals (Sweden)

    Bertheau Yves

    2000-07-01

    Full Text Available Les récentes affaires de semences conventionnelles de colza et de maïs contaminées par des traces d’OGM ont à nouveau, s’il en était besoin, rappelé à notre bon souvenir les besoins en méthodes de détection et d’identification des OGM fiables et sensibles. Les développements se poursuivent, certes bien plus lentement qu’initialement espéré du fait du nombre important de facteurs à maîtriser et du caractère relativement inédit de ce travail. Concernant des matrices alimentaires variées, cette détection se heurte au manque de recul dans plusieurs domaines tels que celui de l’extraction et la purification d’acides nucléiques en quantité et en qualité. Bien que développées pour satisfaire aux besoins réglementaires européens concernant l’alimentation humaine, ces méthodes devraient être aisément applicables dans d’autres domaines concernés par les OGM (étude des transferts de gènes par flux pollinique, éventuels transferts horizontaux, suivi des acides nucléiques lors de l’ingestion.... Au-delà des OGM, les méthodes mises en œuvre devraient présenter un intérêt dans d’autres domaines comme la microbiologie, l’épidémiologie ou l’authentification des composants biologiques d’un produit.

  7. Choice of Method of Collection and Measurement for an Aerosol Monitor with Filter; Choix du Mode de Collection et de Mesure pour un Moniteur d'Aerosols a Filtre

    Energy Technology Data Exchange (ETDEWEB)

    Lafont-Rapnouil, M. [Compagnie Francaise Thomson Houston-Hotchkiss Brandt, Chatou (France)

    1967-12-15

    surveillance continue de l'atmosphere, conduit a penser qu'une solution interessante aux problemes de base poses par ce type d'appareil consiste a employer un filtre fixe dont l'activite est mesuree pendant le prelevement. Ce procede procure en outre d'autres avantages; simplicite, bon rendement de detection, rapidite de reponse, homogeneite du depot devant le detecteur, exploitation commode. L'emploi d'un filtre fixe n'exclut pas son remplacement automatique par un systeme d'avance pas a pas qui peut lui-meme etre asservi au declenchement de l'alarme. On decrit brievement un exemple de realisation de tetes de prelevement repondant aux criteres ci-dessus et de porte-filtres qui leur sont associes. Ces tetes peuvent etre equipees de differents detecteurs (alpha, beta ou mixtes: tubes Geiger-Mueller, scintillateurs ou sem i-conducteurs) et permettent un changement aise du filtre. Le choix de ces principes ne met pas en cause les autres aspects fort complexes de la validite globale de l'echantillon et permet de resoudre de maniere simple les problemes courants en matiere de radioactivite des aerosols. (author)

  8. Elusloom lennukiga puhkusele / Inge Parring

    Index Scriptorium Estoniae

    Parring, Inge

    2003-01-01

    Ilmunud ka: Delovõje Vedomosti 1. okt. lk. 13. Air Cargo Estonia/ACE Logisticsi müügijuht Inge Parring tutvustab elusloomade transpordivõimalusi. Vt. samas: Loomade transportimiseks vajalikud dokumendid

  9. Par Pond vegetation status 1996

    International Nuclear Information System (INIS)

    Mackey, H.E. Jr.; Riley, R.S.

    1996-12-01

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the newly emergent, shoreline aquatic plant communities of Par Pond began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level. These surveys continued in July, September, and late October, 1995, and into the early spring and late summer of 1996. Communities similar to the pre-drawdown, Par Pond aquatic plant communities continue to become re-established. Emergent beds of maidencane, lotus, waterlily, watershield, and Pontederia are extensive and well developed. Measures of percent cover, width of beds, and estimates of area of coverage with satellite data indicate regrowth within two years of from 40 to 60% of levels prior to the draw down. Cattail occurrence continued to increase during the summer of 1996, especially in the former warm arm of Par Pond, but large beds common to Par Pond prior to the draw down still have not formed. Lotus has invaded and occupies many of the areas formerly dominated by cattail beds. To track the continued development of macrophytes in Par Pond, future surveys through the summer and early fall of 1997, along with the evaluation of satellite data to map the extent of the macrophyte beds of Par Pond, are planned

  10. Sources de photons uniques et expérience à choix retardé de Wheeler : la dualité onde corpuscule à l'épreuve de l'expérience

    Science.gov (United States)

    Jacques, V.

    ésentations classiques de la réalité physique incompatibles. Le travail décrit dans cet ouvrage s'inscrit dans l'étude de la dualité onde-corpuscule pour un photon unique à l'aide d'une source de photons uniques fondée sur l'excitation impulsionnelle d'un centre coloré NV individuel dans un nanocristal de diamant. Nous présentons dans un premier temps une expérience d'interférence à un photon très proche dans sa conception de celle des trous d'Young. Cette expérience nous permettra de discuter de la complémentarité entre interférence et connaissance du chemin suivi par la particule dans l'interféromètre. Pour aller un peu plus au cÅ`ur des problèmes conceptuels soulevés par la dualité onde-corpuscule, nous décrivons par la suite la réalisation expérimentale de l'expérience de pensée dite de “choix retardé” proposée par Wheeler au début des années soixante-dix. Dans cette expérience, la décision de fermer ou non l'interféromètre, et donc d'observer soit les interférences (associé à une propriété ondulatoire) soit le chemin suivi par le photon dans l'interféromètre (associé à une propriété de type corpusculaire), n'est prise qu'une fois que le photon a franchi l'élément séparateur à l'entrée de l'interféromètre. Les résultats de cette expérience nous permettront de conclure qu'aucune réalité physique classique ne saurait être attribuée au photon indépendamment de l'appareil de mesure, comme le stipule le principe de complémentarité.

  11. Comment faire la part des choses ? Une sociologie des dispositifs d’aide aux choix

    Directory of Open Access Journals (Sweden)

    Samuel Lézé

    2011-03-01

    Full Text Available Les consommateurs contemporains doivent faire face à une offre de plus en plus com­plexe constituée de produits a priori équivalents en termes d’utilité, de qualité ou de prix comme, par exemple, une automobile : Peugeot Partner 2.0 HDI ou Renault Kangoo 4X4 1.9 dCi. Cette situation s’apparente au fameux paradoxe philosophique de l’âne de Buridan : soit un âne affamé placé à égale distance de deux quantités semblables de nourriture, deux bottes de foin identiques. Incapable de choisir, il fin...

  12. Profil bactériologique du pied diabétique et son impact sur le choix des antibiotiques

    Science.gov (United States)

    Zemmouri, Adil; Tarchouli, Mohamed; Benbouha, Abdellatif; Lamkinsi, Tarik; Bensghir, Mustapha; Elouennass, Mostafa; Haimeur, Cherqui

    2015-01-01

    Introduction Analyse du profil bactériologique des pieds diabétiques pris en charge à l'hôpital militaire de Rabat et son influence sur l'antibiothérapie de première intention. Méthodes Etude prospective non randomisée étalée sur 18 mois, ayant concerné 105 patients. Après recueil des données et en attente des résultats bactériologiques nos patients ont été divisés en deux groupes: un groupe a été mis sous Amoxicilline + Acide clavulanique + Gentamycine (59 patients) et un groupe sous Ertapénème±Gentamycine (46 patients). Résultats L’étude a regroupé 85 hommes et 20 femmes (sexe ratio = 4.26). L’âge moyen est de 64.4 ans. La gangrène a été observée chez 79% des malades; elle était humide-donc surinfectée en principe- dans 43% des cas. Par ailleurs, 67% des malades ont un chiffre de globules blancs 12000 définissant une infection sévère. L'ostéolyse a été mise en évidence chez 27% de nos patients. Parmi les différentes techniques de prélèvements: 81% ont été profonds dont 21% de biopsie osseuse per opératoire et 14% de prélèvements combinés. 42% de ces prélèvements sont poly microbiens et 21% sont stériles. Les résultats bactériologiques viennent confirmer la prédominance des bactéries aérobies à Gram positif. Le taux de remplacement de l'Ertapénème est de 22% contre un taux de 50% pour l'Amoxiclav. Conclusion L'antibiothérapie ne doit être instaurée qu'en cas d'infection du pied diabétique diagnostiquée sur les critères cliniques établis par les consensus internationaux récents. Le respect des mesures de lutte contre la diffusion de la résistance bactérienne s'avère primordiale. PMID:27386024

  13. La recomposition des parcours dans les universités françaises à la lumière du choix professionnel  The Recombining of Routes in French Universities in the Light of Professional Choices

    Directory of Open Access Journals (Sweden)

    Renaud Debailly

    2011-12-01

    Full Text Available Cet article analyse le développement des filières professionnelles dans l’enseignement supérieur en France à partir des choix d’orientation des étudiants. En se centrant sur les trajectoires étudiantes dans les différentes filières de l’enseignement supérieur, il s’agit d’analyser la place des filières professionnelles dans les choix d’orientation et dans la construction des projets scolaires et professionnels. L’article montre que le choix professionnel ne mobilise pas les mêmes logiques sociales d’orientation au niveau des premier et deuxième cycles universitaires. Si la position sociale des parents et l’enseignement secondaire sont déterminants dans le choix d’orientation à l’entrée de l’enseignement supérieur, la projection et le rapport à l’avenir tendent à prendre une place prépondérante à partir du master.This article analyses the development of professional pathways in higher education in France beginning with the students’ choices of orientation. In centring themselves on the trajectories of females in the various paths of higher education, it is a question of analysing the place of these professional pathways in the choices of orientation and the construction of scholarly and professional projects. The article shows that the professional choice does not mobilize the same social logics of orientation on the level of the first and second university cycles. If the parents’ social position and the secondary education are determinant in the choice of orientation at the entry into higher education, the project and the relationship to the future tend to take a dominating place beginning with the master’s.

  14. L’effet de la personnalité sur la performance des étudiants universitaires en sciences de l’administration à l’examen écrit, au test à choix multiple et aux travaux pratiques

    Directory of Open Access Journals (Sweden)

    Sawsen Lakhal

    2017-03-01

    Full Text Available Plusieurs programmes universitaires en sciences de l’administration au Canada ont implanté des réformes majeures, suite aux demandes des organismes d’agrément tels que l’Association to Advance Collegiate Schools of Business (AACSB. Conséquemment, de plus en plus de méthodes d’évaluation des apprentissages sont utilisées. Toutefois, l’introduction de ces méthodes dans les programmes d’études pourrait engendrer des biais aux résultats de l’évaluation des apprentissages. L’étude des facteurs pouvant avoir un effet sur la performance des étudiants aux différentes méthodes d’évaluation devient pertinente dans ce contexte. Ainsi, l’objectif de cette étude consiste à vérifier si la personnalité telle que définie par le modèle des cinq facteurs influence la performance à l’examen écrit, au test à choix multiples et aux travaux pratiques. Deux variables contrôle, le genre et l’âge, sont inclus dans les analyses. Un échantillon de 378 étudiants inscrits à un cours de premier cycle universitaire en sciences de l’administration a répondu à un questionnaire en ligne. Les résultats des analyses des régressions linéaires multiples indiquent que ce ne sont pas toujours les mêmes facteurs de la personnalité qui sont sollicités d’une méthode d’évaluation à l’autre, indiquant l’existence potentielle de biais à l’évaluation des apprentissages. Ces résultats sont discutés au regard de la littérature plus large dans le domaine et touchant à d’autres programmes d’études universitaires. In Canada, a number of university programs in business administration have imbedded major reforms, following requests from accreditation bodies such as the Association to Advance Collegiate Schools of Business (AACSB. Consequently, more and more learning assessment methods are used. However, the introduction of these methods in curricula could lead to bias to the results of learning assessment. In

  15. L'impact de la « démocratie sportive » sur le « Service public du sport en Afrique et par ricochet au Cameroun »

    Directory of Open Access Journals (Sweden)

    Dikoume François Claude

    2016-01-01

    Full Text Available Cet article s'attache à démontrer que la posture d'étatisation du sport en Afrique ayant cour depuis les années d'indépendance a subi des mutations considérables grâce à l'évolution de l'histoire du monde. Par ailleurs, aucun des acteurs du mouvement sportif ne peut se targuer de pouvoir gérer l'entièreté de son domaine tout seul. Les rôles des uns et des autres sont désormais bien définis au Cameroun en particulier, grâce à la loi n∘ 2011/018 du 15 juillet 2011 relative à l'organisation et à la promotion des activités physiques et sportives et les textes subséquents pris au fur à mesure à divers niveaux de responsabilité. Ainsi par exemple : la gestion des équipes nationales relèvent désormais presque exclusivement des fédérations sportives nationales ; une fédération sportive nationale ne peut plus être juge et partie en ce qui concerne les litiges d'ordre sportif (y compris le contentieux électoral en son sein. Il est question de faire une analyse succincte des orientations, transformations et évolutions de cette étatisation et des méthodes antidémocratiques du sport en Afrique, afin d'en tirer les nouvelles tendances que les Etats africains mettent en place.

  16. Amartya Kumar Sen, La démocratie des autres. Pourquoi la liberté n’est pas une invention de l’Occident, traduit de l’américain par Monique Bégot, Paris, Payot et Rivages (Manuels Payot, 85 p., 10 euros.

    Directory of Open Access Journals (Sweden)

    Muriel Gilardone

    2006-04-01

    Full Text Available La démocratie est certainement le fil conducteur de l’ensemble de l’œuvre – a priori épars – de l’économiste et philosophe Amartya Sen. D’une part, sa foi en la démocratie apparaît comme la raison première de sa volonté de défier le « théorème d’impossibilité » établi par Kenneth Arrow au début des années cinquante, et comme une ligne directrice dans sa recherche en théorie du choix social. D’autre part, dans ses analyses de problèmes sociaux plus empiriques, comme la famine ou les inégalités...

  17. Par Pond Fish, Water, and Sediment Chemistry

    Energy Technology Data Exchange (ETDEWEB)

    Paller, M.H. [Westinghouse Savannah River Company, AIKEN, SC (United States); Wike, L.D.

    1996-06-01

    The objectives of this report are to describe the Par Pond fish community and the impact of the drawdown and refill on the community, describe contaminant levels in Par Pond fish, sediments, and water and indicate how contaminant concentrations and distributions were affected by the drawdown and refill, and predict possible effects of future water level fluctuations in Par Pond.

  18. Par Pond Fish, Water, and Sediment Chemistry

    International Nuclear Information System (INIS)

    Paller, M.H.; Wike, L.D.

    1996-06-01

    The objectives of this report are to describe the Par Pond fish community and the impact of the drawdown and refill on the community, describe contaminant levels in Par Pond fish, sediments, and water and indicate how contaminant concentrations and distributions were affected by the drawdown and refill, and predict possible effects of future water level fluctuations in Par Pond

  19. Métallisation de guide d'onde en matériau composite à matrice époxy par un procédé DLI-MOCVD

    OpenAIRE

    Addou, Fouzi

    2017-01-01

    La fabrication de guides d’ondes à partir d’un matériau composite CFRP isolant, nécessite de rendre la surface interne conductrice électriquement. Cela peut s’effectuer par métallisation, mais des verrous technologiques apparaissent en raison de la géométrie complexe associée à une surface inerte. Le CFRP est composé d’époxy dont la température de transition vitreuse est de 216 °C, ce qui limite le choix des techniques de métallisation. De plus, l’énergie de surface du polymère qui compose la...

  20. Directed and persistent movement arises from mechanochemistry of the ParA/ParB system.

    Science.gov (United States)

    Hu, Longhua; Vecchiarelli, Anthony G; Mizuuchi, Kiyoshi; Neuman, Keir C; Liu, Jian

    2015-12-22

    The segregation of DNA before cell division is essential for faithful genetic inheritance. In many bacteria, segregation of low-copy number plasmids involves an active partition system composed of a nonspecific DNA-binding ATPase, ParA, and its stimulator protein ParB. The ParA/ParB system drives directed and persistent movement of DNA cargo both in vivo and in vitro. Filament-based models akin to actin/microtubule-driven motility were proposed for plasmid segregation mediated by ParA. Recent experiments challenge this view and suggest that ParA/ParB system motility is driven by a diffusion ratchet mechanism in which ParB-coated plasmid both creates and follows a ParA gradient on the nucleoid surface. However, the detailed mechanism of ParA/ParB-mediated directed and persistent movement remains unknown. Here, we develop a theoretical model describing ParA/ParB-mediated motility. We show that the ParA/ParB system can work as a Brownian ratchet, which effectively couples the ATPase-dependent cycling of ParA-nucleoid affinity to the motion of the ParB-bound cargo. Paradoxically, this resulting processive motion relies on quenching diffusive plasmid motion through a large number of transient ParA/ParB-mediated tethers to the nucleoid surface. Our work thus sheds light on an emergent phenomenon in which nonmotor proteins work collectively via mechanochemical coupling to propel cargos-an ingenious solution shaped by evolution to cope with the lack of processive motor proteins in bacteria.

  1. Le domaine des co-infections et des maladies concomitantes du Réseau canadien pour les essais VIH des IRSC : lignes directrices canadiennes pour la prise en charge et le traitement de la co-infection par le VIH et l’hépatite C chez les adultes

    Science.gov (United States)

    Hull, Mark; Giguère, Pierre; Klein, Marina; Shafran, Stephen; Tseng, Alice; Côté, Pierre; Poliquin, Marc; Cooper, Curtis

    2014-01-01

    HISTORIQUE : De 20 % à 30 % des Canadiens qui vivent avec le VIH sont co-infectés par le virus de l’hépatite C (VHC), lequel est responsable d’une morbidité et d’une mortalité importantes. La prise en charge du VIH et du VHC est plus complexe en raison de l’évolution accélérée de la maladie hépatique, du choix et des critères d’initiation de la thérapie antirétrovirale et du traitement anti-VHC, de la prise en charge de la santé mentale et des toxicomanies, des obstacles socioéconomiques et des interactions entre les nouvelles thérapies antivirales à action directe du VHC et les antirétroviraux OBJECTIF : Élaborer des normes nationales de prise en charge des adultes co-infectés par le VHC et le VIH dans le contexte canadien. MÉTHODOLOGIE : Le Réseau canadien pour les essais VIH des Instituts de recherche en santé du Canada a réuni un groupe d’experts possédant des compétences cliniques en co-infection par le VIH et le VHC pour réviser les publications à jour ainsi que les lignes directrices et les protocoles en place. Après une vaste sollicitation afin d’obtenir des points de vue, le groupe de travail a approuvé des recommandations consensuelles, qu’il a caractérisées au moyen d’une échelle de qualité des preuves fondée sur la classe (bienfaits par rapport aux préjudices) et sur la catégorie (degré de certitude). RÉSULTATS : Toutes les personnes co-infectées par le VIH et le VHC devraient subir une évaluation en vue de recevoir un traitement du VHC. Les personnes qui ne sont pas en mesure d’entreprendre un traitement du VHC devraient être soignées pour le VIH afin de ralentir l’évolution de la maladie hépatique. La norme de traitement du VHC de génotype 1 est un régime comprenant de l’interféron pégylé et de la ribavirine dosée en fonction du poids, associés à un inhibiteur de la protéase du VHC. Pour les génotypes 2 ou 3, une bithérapie classique est recommandée pendant 24 semaines s

  2. Seasonal fluctuations in prevalence of dog intestinal parasites in public squares of Mar del Plata city, Argentina and its risk for humans Estacionalidad en la prevalencia de parásitos intestinales caninos en plazas públicas de Mar del Plata, Argentina, y su riesgo para la salud humana

    Directory of Open Access Journals (Sweden)

    V. Andresiuk

    2007-12-01

    Full Text Available The aim of this work is to analyze whether there is a seasonal prevalence of parasites in dog feces from public squares in Mar del Plata city, Argentina, and to evaluate the climatic conditions that promote the development of parasites and allow the transmission to people. The study was performed in 21 squares from June 2001 to May 2002. Samples were processed by the Willis technique. Differences in prevalence of parasites were examined for significance by the Chisquare test. Climatic data were obtained from the Library of the National Meteorological Service of Argentina. Total parasitic prevalence was higher in winter than in summer. The prevalence of Ancylostoma spp. was higher in the summer-autumn period. For Toxocara canis, the prevalence was higher in winter whereas for Trichuris vulpis, it was higher in winter, spring and summer. This work shows high prevalence of total parasites throughout the year. For Ancylostoma spp., summer and autumn might be the seasons with higher sanitary risk. On the other hand, T. canis could present the higher risk to people in winter and, T. vulpis, would be transmitted throughout the whole year. The seasonal variation in prevalence of dog parasites results in continuous exposure to people visiting the squares, not only Mar del Plata residents but also tourists from other regions of Argentina and the world, with at least one species of parasite with sanitary risk.El objetivo de este trabajo es analizar la variación estacional de la prevalencia de los parásitos presentes en las heces caninas halladas en plazas públicas de la ciudad de Mar del Plata y evaluar aquellas condiciones climáticas que promueven su desarrollo y permiten su transmisión a la gente. El estudio se realizó en 21 plazas desde junio de 2001 hasta mayo de 2002. Las muestras fueron procesadas con la técnica de Willis. Se utilizó el test de c² para comparar la prevalencia de los diferentes parásitos. Los datos climáticos fueron

  3. Free diffusion of translation of macromolecules in solution with the rayleigh interferometer; Diffusion libre de translation des macromolecules en solution, par interferometrie de rayleigh

    Energy Technology Data Exchange (ETDEWEB)

    Leger, J J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1969-07-01

    The aim of this study is to develop a rapid and accurate measurement, with the Rayleigh interferometer, of the free diffusion coefficient of translation of macromolecules in solution. After having explained the choice of a diffusion cell with laminar lateral flow, and explained the principle of the Rayleigh interferometer, a semi-automatic technique of free diffusion are then introduced. Solutions are proposed for systems composed of two or three components, such as biopolymers. The paper ends by drafting the possible treatment of recorded experimental data by means of electronic computer. (author) [French] Cette etude a ete entreprise pour mettre au point une methode precise et rapide de mesure, par interferometre de Rayleigh, du coefficient de diffusion libre de translation des macromolecules en solution. Apres avoir justifie le choix d'une cellule de diffusion a ecoulement laminaire lateral et explique le principe de l'interferometre de Rayleigh, l'auteur decrit une technique semi-automatique d'enregistrement des cliches d'interference. Il introduit ensuite les equations differentielles de diffusion libre et propose des solutions pour les systemes a deux et trois composants applicables aux biopolymeres. L'article se termine par une esquisse concernant le traitement des donnees experimentales enregistrees au moyen du calcul electronique. (auteur)

  4. Ultrasonic testing of canning tubes in stainless steel of the EL 4 reactor; Controle par ultrasons des tubes de gaine en acier inoxydable du reacteur EL 4

    Energy Technology Data Exchange (ETDEWEB)

    Prot, A; Monnier, P [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1964-07-01

    From all the methods possible for controlling thin cans the one chosen, for numerous reasons, vas that making use of ultrasonic techniques. A method has been developed which should make it possible to carry out a rapid and efficient industrial control of canning tubes, The reasons for the choice of the ultrasonic method are given in detail, together with the principles of the method and the actual control parameters. In the present state of our research, it should be possible to control at least 50 000 tubes a year. Improvements brought about in the details of the control technique itself should make it possible to increase this rate considerably. (authors) [French] Parmi toutes les methodes possibles de controle des gaines minces, le procede retenu pour de multiples raisons a ete celui faisant appel a la technique des ultrasons. Une methode a ete mise au point qui doit permettre un controle industriel rapide et efficace des tubes de gaine. Sont exposes en detail, les raisons du choix de la methode par ultrasons, les principes de cette methode et les parametres du controle proprement dit. Dans l'etat actuel de nos etudes la cadence devrait permettre le controle de 50000 tubes par an au minimum. Des ameliorations de detail portant sur la technique de controle elle-meme, doivent permettre d'accelerer tres notablement cette cadence. (auteurs)

  5. Publications | Page 11 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    insurrection syrienne. Les récentes projections à Ottawa du film primé Little Gandhi: The lost truth of the Syrian uprising ont été chaleureusement accueillies tant par les parlementaires que par le public.

  6. Recherche documentaire par titrage automatique

    OpenAIRE

    Lopez , Cédric; Prince , Violaine; Roche , Mathieu

    2011-01-01

    Nous proposons dans cet article un système facilitant la recherche d'information dans un ensemble de documents textuels, basé sur le titrage (et sous-titrage) automatique. Ce dernier peut se révéler crucial, par exemple, dans le cadre de la problématique de l'accessibilité des pages web (norme W3C). Notre processus de titrage automatique consiste à extraire des syntagmes nominaux pertinents dans les textes, pouvant constituer des titres ou sous-titres candidats. Une approche originale combina...

  7. Energy choices under environmental controversy: the French biofuels case; Controverse environnemental et choix de filieres energetiques: les biocarburants en France

    Energy Technology Data Exchange (ETDEWEB)

    Fallot, A.

    2003-07-01

    In France, the persistence of biofuels at an experimental or pre-industrial stage, hangs on measures that were taken on the account of environmental policy in the energy sector. Our recent and thorough case study has resulted in the statement that biofuels do not offer the prospects for enough profitability to any economic agent - neither biomass providers nor energeticists - that would justify the investments necessary to reach large scale production. A real biofuel 'file' is not viable in a context where fossil energies dominate, nor in a context where the complete taking into account of environmental variables would have defeated the ''technological lock-in'' that nowadays excludes no-carbon technologies. We look for an explanation of the continuing public support to biofuels in the present peculiar context, where new measures of environmental policy are being decided in the energy sector without any agreement on the importance of environmental and other long term issues. For that matter, we propose a simple option value model, where both issues of irreversibility and uncertainty are tackled. (author)

  8. Les dispensées par fantaisie en éducation physique et sportive ...

    African Journals Online (AJOL)

    Cette étude vise à comprendre les raisons avancées par les élèves dispensés par fantaisie des cours d'EPS, pour justifier leur attitude et principalement leur forfait. Une enquête par questionnaire écrit a été menée dans 13 établissements publics de la ville de Porto-Novo au Bénin. Au total, 203 élèves parmi les 771 élèves ...

  9. SECHAGE DE PRODUITS GRANULAIRES PAR DESHYDRATATION PAR DETENTES SUCCESSIVES (DDS)

    OpenAIRE

    Abdulla , Galal; Mellouk , Hamid; Belghit , Abdelhamid; Allaf , Karim

    2009-01-01

    International audience; Dans cette étude, nous avons évalué les performances d'un nouveau procédé de séchage dans le cas du liège en granulés. Ce procédé (La déshydratation par détentes successives : DDS) consiste à soumettre le matériau liège dans une chambre hermétique aux variations cycliques de la pression. Chaque cycle est composé d'une compression et d'une décompression. La phase de compression est réalisée en injectant de l'air comprimé à température ambiante provenant d'un compresseur...

  10. La preuve par le nombre

    Directory of Open Access Journals (Sweden)

    Hélène Verdier

    2012-04-01

    Full Text Available S’il en était besoin, la question des usages et de la finalité des résultats de l’inventaire général pourrait être abordée par le nombre : nombre d’œuvres répertoriées, de communes inventoriées, de clichés photographiques réalisés, de dossiers, de consultations des notices dans les bases de données… Les additions aujourd’hui sont éloquentes, mais elles laissent dans l’ombre le rôle de l’inventaire qui, en mettant en œuvre une démarche systématique de connaissance, participe à l’ identificatio...

  11. Par Pond vegetation status Summer 1995 -- Summary

    International Nuclear Information System (INIS)

    Mackey, H.E. Jr.; Riley, R.S.

    1996-01-01

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the newly emergent, shoreline aquatic plant communities of Par Pond began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level. These surveys continued in July, September, and late October, 1995. Communities similar to the pre-drawdown, Par Pond aquatic plant communities are becoming re-established. Emergent beds of maidencane, lotus, waterlily, and watershield are extensive and well developed. Cattail occurrence continued to increase during the summer, but large beds common to Par Pond prior to the drawdown have not formed. Estimates from SPOT HRV, remote sensing satellite data indicated that as much as 120 hectares of emergent wetlands vegetation may have been present along the Par Pond shoreline by early October, 1995. To track the continued development of macrophytes in Par Pond, future surveys throughout 1996 and 1997, along with the continued evaluation of satellite data to map the areal extent of the macrophyte beds of Par Pond, are planned

  12. Revamping and Expanding Domestic Electricity Supply. Law draft adopted by the National Assembly; Projet de Loi relatif a la Modernisation et au Developpement du Service Public de l'Electricite adopte par l'Assemblee Nationale

    Energy Technology Data Exchange (ETDEWEB)

    National Assembly [ed.] [Assemblee Nationale, Paris (France)

    1999-03-02

    This document presents the draft of the law regarding the revamping and expanding the domestic electricity supply, adopted by the French National Assembly. The first Title devoted to the definition of the domestic electricity supply contains 5 articles. The second Title deals with the production of electricity in the articles 6 through 12. Title three concerns the transport and electricity distribution issue exposed in articles 13 through 21 and three chapters titled: - Chap. 1, Transport of electricity; - Chap. 2, Distribution of electricity; - Chap.3, Safety and security of the grids. The Title four concerns with the access to domestic electricity grids exposed in the articles 22 to 24. The fifth Title settles in articles 25 to 27 the issue of the dissociation and transparency of accounting. The articles 28 through 41 treat under Title six the problems of Regulation. The Object of Electricity Authority of France is stipulated in the Title seven containing only the article 42. Social issues are stipulated in Title eight containing two articles, the first one being a completion to Chapter III of the Title seven in the Labour Law, titled 'Electricity and Gas Industries'. Finally, the Title nine comprising articles 45 to 52 deals with Diverse and Transient Provisions. The law draft was debated in public session in Paris on 2 March and signed by the President Laurent Fabius.

  13. Systèmes multimatériaux – Assemblage par collage Multimaterial systems – Adhesive bonding

    Directory of Open Access Journals (Sweden)

    Zuanna C. Dalla

    2013-11-01

    Full Text Available L'assemblage par collage multimatériaux (métal/composite, métal/verre, métal/plastiques, verre/plastiques… offre de nombreux avantages par rapport aux techniques d'assemblages traditionnelles (pas d'affaiblissement des matériaux par la température, tenues en fatigue et à la corrosion améliorées, esthétisme, étanchéité…. Cependant la qualité et la durabilité à long terme des assemblages collés dépendent d'une bonne conception de ces assemblages : Le choix de préparations de surfaces efficaces, robustes, facilement industrialisables et respectueuses de l'environnement, Le choix d'adhésifs aptes à répondre au cahier des charges fonctionnel de l'assemblage (performances mécaniques, thermiques, chimiques… dont la mise en œuvre est compatible avec les contraintes d'industrialisation (cadences, temps de manipulation des pièces, environnement du poste collage…, Le dessin et le dimensionnement de la liaison de façon à transmettre les efforts mécaniques spécifiés dans la plage de températures de fonctionnement des pièces collées (en tenant compte des dilatations différentielles des matériaux assemblés. Cette démarche sera développée en donnant l'état de l'art actuel et les avancées les plus récentes sur les trois thèmes cités ci-dessus. Adhesive-bonding offers many advantages over traditional joining techniques (no weakening of materials by temperature, required fatigue and improved corrosion resistance, aesthetics, sealing… for multimaterial assembly (metal/composite, metal/glass, metal/plastic, glass/plastic…. However the quality and long term durability of bonded assemblies depend on a correct design of the joint: Choice of eco-efficient surfaces preparations, robust, and easily processed, Choice of adhesive in good adequation with the functional specifications of the assembly (mechanical performance, thermal, chemical… whose implementation is compatible with industrialization constraints

  14. Poser et reposer des choix.

    Directory of Open Access Journals (Sweden)

    Corinne Van Hauwermeiren- Echement

    2009-10-01

    Full Text Available IntroductionEn 1955, le legs de la collection Franckignoul – composée notamment d’un ensemble de quatre panneaux du XVIe siècle – vient enrichir les collections du Musée des Beaux-Arts de la Ville de Liège (Belgique. La fermeture de ce dernier en 1976 débouche sur  la scission des collections. Une partie est donnée au Musée de l’Art Wallon, l’autre partie allant au Musée d’Art Moderne et d’Art Contemporain (Mamac. Toutes les œuvres n’entrant pas dans ces deux collections sont reléguées en r...

  15. ParTIES: a toolbox for Paramecium interspersed DNA elimination studies.

    Science.gov (United States)

    Denby Wilkes, Cyril; Arnaiz, Olivier; Sperling, Linda

    2016-02-15

    Developmental DNA elimination occurs in a wide variety of multicellular organisms, but ciliates are the only single-celled eukaryotes in which this phenomenon has been reported. Despite considerable interest in ciliates as models for DNA elimination, no standard methods for identification and characterization of the eliminated sequences are currently available. We present the Paramecium Toolbox for Interspersed DNA Elimination Studies (ParTIES), designed for Paramecium species, that (i) identifies eliminated sequences, (ii) measures their presence in a sequencing sample and (iii) detects rare elimination polymorphisms. ParTIES is multi-threaded Perl software available at https://github.com/oarnaiz/ParTIES. ParTIES is distributed under the GNU General Public Licence v3. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  16. mTORC2 activation is regulated by the urokinase receptor (uPAR) in bladder cancer.

    Science.gov (United States)

    Hau, Andrew M; Leivo, Mariah Z; Gilder, Andrew S; Hu, Jing-Jing; Gonias, Steven L; Hansel, Donna E

    2017-01-01

    Mammalian target of rapamycin complex 2 (mTORC2) has been identified as a major regulator of bladder cancer cell migration and invasion. Upstream pathways that mediate mTORC2 activation remain poorly defined. Urokinase-type plasminogen activator receptor (uPAR) is a GPI-anchored membrane protein and known activator of cell-signaling. We identified increased uPAR expression in 94% of invasive human bladder cancers and in 54-71% of non-invasive bladder cancers, depending on grade. Normal urothelium was uPAR-immunonegative. Analysis of publicly available datasets identified uPAR gene amplification or mRNA upregulation in a subset of bladder cancer patients with reduced overall survival. Using biochemical approaches, we showed that uPAR activates mTORC2 in bladder cancer cells. Highly invasive bladder cancer cell lines, including T24, J82 and UM-UC-3 cells, showed increased uPAR mRNA expression and protein levels compared with the less aggressive cell lines, UROtsa and RT4. uPAR gene-silencing significantly reduced phosphorylation of Serine-473 in Akt, an mTORC2 target. uPAR gene-silencing also reduced bladder cancer cell migration and Matrigel invasion. S473 phosphorylation was observed by immunohistochemistry in human bladder cancers only when the tumors expressed high levels of uPAR. S473 phosphorylation was not controlled by uPAR in bladder cancer cell lines that are PTEN-negative; however, this result probably did not reflect altered mTORC2 regulation. Instead, PTEN deficiency de-repressed alternative kinases that phosphorylate S473. Our results suggest that uPAR and mTORC2 are components of a single cell-signaling pathway. Targeting uPAR or mTORC2 may be beneficial in patients with bladder cancer. Copyright © 2016. Published by Elsevier Inc.

  17. ¡París!

    Directory of Open Access Journals (Sweden)

    Beatriz Caballero

    2003-01-01

    Full Text Available El día no le alcanzaba para caminarlo. Conocía cada puente, cada calle,plaza, museo, rincón, iglesia, café, y la mesa con el mejor ángulo para mirar siempre una iglesia, ojalá Saint-Germain-des-Pres, o Notre-Dame. Siempre contaba la impresión que le había causado a Bolívar ver allí cuando el papa coronó a Napoleón. Él se iba para la oficina todos los días, Luis a un taller a pintar, Antonio a estudiar ciencias políticas, yo al colegio y mamá hacía las cosas prácticas. Aprendíamos francés todos al tiempo y por la noche nos contábamos lo nuevo que cada uno había aprendido. Mamá después, cuando ya se quería volver, decía que París nos había maleado a todos. Estaba en pleno furor el cine francés de la "nueva ola", pero ella sólo me llevaba a ver películas de vaqueros pues no se fiaba de la clasificación de los periódicos.

  18. Le Domaine des Co-infections et des Maladies Concomitantes du Réseau Canadien pour les Essais VIH des IRSC : Lignes Directrices Canadiennes pour la Prise en Charge et le Traitement de la Co-Infection par le VIH et l’Hépatite C chez les Adultes

    Directory of Open Access Journals (Sweden)

    Mark Hull

    2014-01-01

    Full Text Available HISTORIQUE: De 20 % à 30 % des Canadiens qui vivent avec le VIH sont co-infectés par le virus de l’hépatite C (VHC, lequel est responsable d’une morbidité et d’une mortalité importantes. La prise en charge du VIH et du VHC est plus complexe en raison de l’évolution accélérée de la maladie hépatique, du choix et des critères d’initiation de la thérapie antirétrovirale et du traitement anti-VHC, de la prise en charge de la santé mentale et des toxicomanies, des obstacles socioéconomiques et des interactions entre les nouvelles thérapies antivirales à action directe du VHC et les antirétroviraux

  19. Narrative Identities and the Plebiscite in Pará: An Analysis of the Front Pages for O Liberal and Diário do Pará

    Directory of Open Access Journals (Sweden)

    Alda Cristina Silva da Costa

    2017-05-01

    Full Text Available On December 11, 2011, a plebiscite was held in Pará proposing to create two separatist states, Carajás and Tapajós, out of the state of Pará. The public voted against both projects. This article analyzes the narrative identities found on the front pages of O Liberal and Diário do Pará newspapers about the plebiscite in Pará. Depth Hermeneutics (DH, as proposed by Thompson (2011, was used as the methodological reference. DH emphasizes the object of analysis as a meaningful symbolic construction requiring interpretation. Narrative analysis, as proposed by Motta (2007, was the main research technique used to highlight the movement of construction of journalistic (discursive characters. The narrative identities built by the two newspapers showed that both were against the creation of the new states, but for very different reasons. The flag of Pará was the main object used to induce the idea of unity. Em 11 de dezembro de 2011, o plebiscito no Pará propôs a criação dos estados de Carajás e de Tapajós a partir da divisão do estado do Pará. O resultado da consulta pública foi negativo aos dois projetos. O artigo analisa as identidades narrativas constituídas pelas primeiras páginas dos jornais O Liberal e Diário do Pará sobre o plebiscito no Pará. Utilizou-se como referencial metodológico a Hermenêutica em Profundidade (HP, proposta por Thompson (2011. A HP evidencia o fato de que o objeto de análise é uma construção simbólica significativa, que exige uma interpretação. Como principal técnica de pesquisa, a análise narrativa, proposta por Motta (2007, com ênfase no movimento de construção de personagens jornalísticas (discursivas. As identidades narrativas construídas pelos dois jornais indicaram que ambos eram contrários à criação dos novos estados, porém por motivos divergentes. A bandeira do Pará foi o principal elemento utilizado para evocar a ideia de unidade. En 11 de diciembre de 2011, el plebiscito en

  20. C9.A/14 steelwork joints de poutres par plaque frontale : assemblages par gousset

    CERN Document Server

    2015-01-01

    Les Tables de résistances ultimes des assemblages boulonnés par plaque frontale et par gousset, complétées par une description des modèles de calcul et des exemples d’application, ont pour but de faciliter la tâche de l'ingénieur et du constructeur. Cette première partie C9.A/14 contient les chapitres suivants: - Joints de poutres par plaque frontale en acier S235 et S355 - Assemblages par gousset en acier S235 et S355 Les Tables contiennent des données relatives à la géométrie ainsi que les valeurs de calcul correspondantes des résistances ultimes des assemblages ; elles remplacent le chapitre « Assemblages par plaques frontales et boulons HR » des anciennes Tables C9.1 de 1983 / 2002. Le calcul de ces assemblages par plaque frontale est basé sur les hypothèses du modèle de la méthode des composants décrite dans la norme SN EN 1993-1-8. Les vérifications sont effectuées selon la norme SIA 263:2013. Les assemblages par gousset remplacent les assemblages par double cornière, (telle...

  1. The choice of sites considered with respect to problems of radioactive waste disposal; Le choix des sites considere dans ses rapports avec les problemes de rejets d'effluents radioactifs

    Energy Technology Data Exchange (ETDEWEB)

    Duhamel, F [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1960-07-01

    The author of this article shows clearly that a knowledge of the behaviour of wastes together with an analysis of the risks of accidents makes it possible to define the general characteristics of a site as a function of, on the one hand the geological and meteorological factors, and on the other, the proposed installations. Consideration of the biological environment makes it possible to clarify the sitological study and to make a choice between the several sites possible. The author shows the real necessity for radio-protection specialists to share their knowledge, to establish regulations, and to cooperate with the authors responsible for the installations, from the moment of the choice of the site and of the planning of the apparatus up to the final reject of the waste. (author) [French] L'auteur de ce rapport montre clairement que la connaissance du comportement des effluents jointe a l'analyse des risques d'accident permettent de degager les caracteristiques generales d'un site en fonction d'une part, des donnees geologiques et meteorologiques, d'autre part des installations projetees. La consideration du milieu biologique permet de preciser l'etude sitologique et d'effectuer un choix entre plusieurs sites donnes. L'auteur met en evidence la necessite absolue pour les specialistes de la radioprotection d'echanger leurs connaissances, d'etablir des reglements et de cooperer avec les autorites responsables des installations depuis le choix des sites et le projet des appareillages jusqu'au rejet ultime des residus. (auteur)

  2. Réduction du nombre de puits par l'utilisation de forages horizontaux Reducing the Number of Wells by Using Horizontal Drilling

    Directory of Open Access Journals (Sweden)

    Giger F.

    2006-11-01

    Full Text Available L'un des intérêts du forage horizontal est le gain de productivité sur chaque puits. L'objet de cet article est de proposer des éléments d'analyse, comme la productivité surfacique, destinés à aider l'instance responsable du développement d'un champ confrontée au choix économique entre un schéma classique par puits verticaux et un autre schéma intégrant des puits d'un autre type, et notamment des drains horizontaux. Des méthodes de résolution approchées d'emploi simple sont proposées pour évaluer le nombre de puits verticaux que peut remplacer un drain ho-rizontal. One of the advantages of horizontal drilling is the increase in productivity of each well. The aim of this article is to propose bases for making an analysis, such as areal productivity, so as to help the decision-maker responsible for the development of a field when confronted with an economic choice between a conventional system using vertical wells and an alternative system including other types of wells, and in particular horizontal wells. Simple and approximate solutions are proposed for evaluating the number of vertical wells that can be replaced by a horizontal wells.

  3. Protease-activated receptor (PAR)-2 is required for PAR-1 signalling in pulmonary fibrosis

    NARCIS (Netherlands)

    Lin, Cong; von der Thüsen, Jan; Daalhuisen, Joost; ten Brink, Marieke; Crestani, Bruno; van der Poll, Tom; Borensztajn, Keren; Spek, C. Arnold

    2015-01-01

    Idiopathic pulmonary fibrosis is the most devastating diffuse fibrosing lung disease of unknown aetiology. Compelling evidence suggests that both protease-activated receptor (PAR)-1 and PAR-2 participate in the development of pulmonary fibrosis. Previous studies have shown that bleomycin-induced

  4. L'apprentissage des langues médiatisé par les technologies (ALMT – Étude d'un domaine de recherche émergent à travers les publications de la revue Alsic Technology-mediated language learning: an emergent research domain under study through the review of a French scientific journal's publications

    Directory of Open Access Journals (Sweden)

    Nicolas Guichon

    2012-11-01

    Full Text Available Dans cette étude, il est postulé que l'apprentissage des langues médiatisé par les technologies (ALMT est un domaine de recherche qui s'intéresse au développement et à l'intégration des technologies dans l'enseignement-apprentissage d'une langue. Ce domaine étant émergent, la présente recherche vise tout d'abord à comprendre comment s'est formée la communauté de chercheurs autour de cet objet. Puis, à travers l'analyse critique de 79 articles publiés dans la revue en ligne francophone Alsic entre 1998 et 2010, la présente contribution s'emploie à définir les contours épistémologiques de ce domaine en étudiant les moyens de production de connaissance.In this study, it is postulated that technology mediated language learning is a research domain that focuses on the design and integration of technologies for language learning and teaching. Because this domain is emergent, the present study first aims at understanding how a community of researchers has developed around this object. Then, thanks to the critical analysis of 79 articles published in Alsic, a French-speaking online journal, the present article endeavours to define the epistemological contours of this research domain by studying the means employed to produce knowledge.

  5. PAR in Academic and Professional Literature: A comparison of the Recent EU Accession Waves

    NARCIS (Netherlands)

    Junjan, Veronica; Nemec, Juraj

    2016-01-01

    The last twenty years have brought about rather tumultuous changes in terms of the way PAR is being defined, conducted, imitated and, why not, simulated. This paper aims to explore the way scientific literature has addressed the issue of reform in public administration through conducting a

  6. ParA and ParB coordinate chromosome segregation with cell elongation and division during Streptomyces sporulation

    Science.gov (United States)

    Donczew, Magdalena; Mackiewicz, Paweł; Wróbel, Agnieszka; Flärdh, Klas; Zakrzewska-Czerwińska, Jolanta

    2016-01-01

    In unicellular bacteria, the ParA and ParB proteins segregate chromosomes and coordinate this process with cell division and chromosome replication. During sporulation of mycelial Streptomyces, ParA and ParB uniformly distribute multiple chromosomes along the filamentous sporogenic hyphal compartment, which then differentiates into a chain of unigenomic spores. However, chromosome segregation must be coordinated with cell elongation and multiple divisions. Here, we addressed the question of whether ParA and ParB are involved in the synchronization of cell-cycle processes during sporulation in Streptomyces. To answer this question, we used time-lapse microscopy, which allows the monitoring of growth and division of single sporogenic hyphae. We showed that sporogenic hyphae stop extending at the time of ParA accumulation and Z-ring formation. We demonstrated that both ParA and ParB affect the rate of hyphal extension. Additionally, we showed that ParA promotes the formation of massive nucleoprotein complexes by ParB. We also showed that FtsZ ring assembly is affected by the ParB protein and/or unsegregated DNA. Our results indicate the existence of a checkpoint between the extension and septation of sporogenic hyphae that involves the ParA and ParB proteins. PMID:27248800

  7. Contribution to the microwave characterisation of superconductive materials by means of sapphire resonators; Contribution a la caracterisation hyperfrequence de materiaux supraconducteurs par des resonateurs-saphirs

    Energy Technology Data Exchange (ETDEWEB)

    Hanus, Xavier

    1993-12-06

    The objective of this research thesis is to find a compact resonant structure which would allow the residual surface impedance of superconductive samples to be simply, quickly and economically characterised. The author first explains why he decided to use a sapphire single-crystal as inner dielectric, given some performance reached by resonant structures equipped with such inner dielectrics, and given constraints adopted from the start. He explains the origin of microwave losses which appear in this type of resonant structure, i.e. respectively the surface impedance as far as metallic losses are concerned, and the sapphire dielectric loss angle for as far as dielectric losses are concerned. The experimental installation and the principle of microwave measurements are described. The performance of different possible solutions of resonant structures from starting criteria is presented. The solution of the cavity-sapphire with a TE{sub 011} resonant mode is derived [French] Le but de cette etude est de trouver une structure resonnante compacte permettant de caracteriser simplement, rapidement et economiquement l'impedance de surface residuelle d'echantillons supraconducteurs. Les contraintes de mise en oeuvre et les performances atteintes par des resonateurs avec saphirs synthetiques justifient le choix d'un tel dielectrique a faible angle de perte. L'evaluation des performances experimentales appuyee par des modelesanalytiques permet de rejeter differentes solutions. Ainsi les resonateurs fermes avec saphirs minces sont rejetes en raison des mauvais contacts metalliques. Les resonateurs ouverts avec saphirs minces et epais sont egalement rejetes, meme pour les modes de resonance en principe confines, en raison des pertes par rayonnement. La seule solution est donc d'utiliser une cavite-saphir TE{sub 011} qui offre une configuration de champs naturellement confines. Des mesures sur une premiere cavite en niobium massif ont permis de selectionner un saphir obtenu par

  8. Contamination potentielle des aliments par des ...

    African Journals Online (AJOL)

    SARA Computers

    la notion de la pollution et de l'exposition aux PCBs, lorsque 77% n'ont pas conscience de cette situation de risque ... 2018). Quoique la contamination par les. PCBs soit de faible niveau, elle est ...... Université Paris-Est, Paris, France ; 183.

  9. CFD analysis of PAR performance as function of inlet design

    Energy Technology Data Exchange (ETDEWEB)

    Park, Kweonha, E-mail: khpark@kmou.ac.kr [Division of Mechanical and Energy systems Engineering, Korea Maritime University, Dongsam-dong, Yeongdo-gu, Busan 606-791 (Korea, Republic of); Khor, Chong Lee, E-mail: itachi_829@hotmail.com [Department of Mechanical Engineering, Korea Maritime University (Korea, Republic of)

    2016-01-15

    Highlights: • The new concept of PAR (passive autocatalytic recombiner) was proposed and analyzed. • Guidance wall was added at the bottom of PAR to enhance the flow rate through the catalyst. • The new concept of PAR was proved to have a better hydrogen removal performance. - Abstract: Passive autocatalytic recombiner (PAR) is very useful hydrogen mitigation measurement. It is widely implemented in the current and advanced light water reactors (ALWRs). The design of the PARs should be optimized for the specific use under severe accident scenarios. Several techniques and innovations have been fused into the PAR, as an effort to increase its efficiency of hydrogen mitigation. This study proposes different concepts of PAR, which applied some changes to the honeycomb catalyst PAR made by the Korea Nuclear Technology (KNT) Inc. Two slices of plate are added to the bottom of PAR model, which intended to act as a reflection wall and promote the gas flow into PAR. Hydrogen volume fraction was given 4 vol. % which tested by KNT to investigate the performance of PAR in different direction gas flow conditions to see maximum hydrogen recombination rate. The new concept of PAR was proved to have a better hydrogen removal performance compared to the original honeycomb catalyst PAR.

  10. CFD analysis of PAR performance as function of inlet design

    International Nuclear Information System (INIS)

    Park, Kweonha; Khor, Chong Lee

    2016-01-01

    Highlights: • The new concept of PAR (passive autocatalytic recombiner) was proposed and analyzed. • Guidance wall was added at the bottom of PAR to enhance the flow rate through the catalyst. • The new concept of PAR was proved to have a better hydrogen removal performance. - Abstract: Passive autocatalytic recombiner (PAR) is very useful hydrogen mitigation measurement. It is widely implemented in the current and advanced light water reactors (ALWRs). The design of the PARs should be optimized for the specific use under severe accident scenarios. Several techniques and innovations have been fused into the PAR, as an effort to increase its efficiency of hydrogen mitigation. This study proposes different concepts of PAR, which applied some changes to the honeycomb catalyst PAR made by the Korea Nuclear Technology (KNT) Inc. Two slices of plate are added to the bottom of PAR model, which intended to act as a reflection wall and promote the gas flow into PAR. Hydrogen volume fraction was given 4 vol. % which tested by KNT to investigate the performance of PAR in different direction gas flow conditions to see maximum hydrogen recombination rate. The new concept of PAR was proved to have a better hydrogen removal performance compared to the original honeycomb catalyst PAR.

  11. SAFARI 2000 PAR Measurements, Kalahari Transect, Botswana, Wet Season 2000

    Data.gov (United States)

    National Aeronautics and Space Administration — Ceptometer data from a Decagon AccuPAR (Model PAR-80) were collected at four sites in Botswana during the SAFARI 2000 Kalahari Transect Wet Season Campaign (March,...

  12. Project of law, adopted by the Senate after urgency declaration, relative to the energy markets and to the energy public utilities; Projet de loi adopte par le Senat apres declaration d'urgence relatif aux marches energetiques et au service public de l'energie

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-10-01

    This project of law treats of: 1 - the right of access to natural gas distribution networks (transit contracts, eligible clients and market opening, acknowledged suppliers, diversification of supplies, denial of contract, derogations); 2 - the transparency and regulation of the natural gas sector (prices and commercial conditions, transport and storage informations, organisation of the regulation authority); 3 - the natural gas public utility (organisation, obligations, supplies warranty and security, national observatory); 4 - the natural gas transport and distribution (network management, expertises and controls, maintenance); 5 - the underground storage (mining law, storage concession, exploitation); 6 - the controls and sanctions; 7 - the dispositions relative to the electric public utility (costs, taxes and contributions, overruns, regulation authority). (J.S.)

  13. Report on the bill concerning the modernization and development of electricity public service, adopted with modifications by the National Assembly at new reading; Rapport sur le project de loi, adopte avec modifications par l'Assemblee nationale en nouvelle lecture, relatif a la modernisation et au developpement du service public de l'electricite

    Energy Technology Data Exchange (ETDEWEB)

    Revol, Henri [Senat, Paris (France)

    2000-01-20

    This document is a report presented on behalf of Commission of Economic Affairs and Plan on the project of law concerning the renovation and development of electricity public service, adopted with modifications by the National Assembly at new reading. The general outlook comprises three points titled: A. Examination conditions showing little respect of Parliament; B. A position of National Assembly inspired of dogmatic considerations; C. A text adopted by the National Assembly which turns the back to Europe and does a disservice to France's industry. The examination of the articles follows. This part is structured on the following titles: The public service of electricity, (five articles); The production of electricity (seven articles); The transport and distribution of electricity (two chapters and nine articles); Access to public electricity grids (three articles); The accounting dissociation and transparency (two articles); Regulation (twelve articles); The object of EDF (one article); Diverse and transient measures (six articles). A comparative table completes the document. It contains the texts adopted by the National Assembly at first reading, the text adopted by the Senate at first reading and the text adopted by the National Assembly at new reading.

  14. Plasma suPAR is lowered by smoking cessation

    DEFF Research Database (Denmark)

    Eugen-Olsen, Jesper; Ladelund, Steen; Sørensen, Lars Tue

    2016-01-01

    BACKGROUND: Soluble urokinase plasminogen activator receptor (suPAR) is a stable inflammatory biomarker. In patients, suPAR is a marker of disease presence, severity and prognosis. In the general population, suPAR is predictive of disease development, such as diabetes and cardiovascular disease a...

  15. Copenhagen uPAR prostate cancer (CuPCa) database

    DEFF Research Database (Denmark)

    Lippert, Solvej; Berg, Kasper D; Høyer-Hansen, Gunilla

    2016-01-01

    AIM: Urokinase plasminogen activator receptor (uPAR) plays a central role during cancer invasion by facilitating pericellular proteolysis. We initiated the prospective 'Copenhagen uPAR Prostate Cancer' study to investigate the significance of uPAR levels in prostate cancer (PCa) patients. METHODS...

  16. The inflammatory marker suPAR after cardiac arrest

    DEFF Research Database (Denmark)

    Rundgren, Malin; Lyngbaek, Stig; Fisker, Helle

    2015-01-01

    . This pilot study aimed at investigating suPAR levels in relation to outcome after CA and mild induced hypothermia. METHODS: suPAR levels were measured at 6, 36, and 72 hours in patients treated with hypothermia after CA. suPAR levels were analyzed in relation to survival after 6 months. Receiver operating...

  17. Phosphorylation of Mycobacterium tuberculosis ParB participates in regulating the ParABS chromosome segregation system.

    Science.gov (United States)

    Baronian, Grégory; Ginda, Katarzyna; Berry, Laurence; Cohen-Gonsaud, Martin; Zakrzewska-Czerwińska, Jolanta; Jakimowicz, Dagmara; Molle, Virginie

    2015-01-01

    Here, we present for the first time that Mycobacterium tuberculosis ParB is phosphorylated by several mycobacterial Ser/Thr protein kinases in vitro. ParB and ParA are the key components of bacterial chromosome segregation apparatus. ParB is a cytosolic conserved protein that binds specifically to centromere-like DNA parS sequences and interacts with ParA, a weak ATPase required for its proper localization. Mass spectrometry identified the presence of ten phosphate groups, thus indicating that ParB is phosphorylated on eight threonines, Thr32, Thr41, Thr53, Thr110, Thr195, and Thr254, Thr300, Thr303 as well as on two serines, Ser5 and Ser239. The phosphorylation sites were further substituted either by alanine to prevent phosphorylation or aspartate to mimic constitutive phosphorylation. Electrophoretic mobility shift assays revealed a drastic inhibition of DNA-binding by ParB phosphomimetic mutant compared to wild type. In addition, bacterial two-hybrid experiments showed a loss of ParA-ParB interaction with the phosphomimetic mutant, indicating that phosphorylation is regulating the recruitment of the partitioning complex. Moreover, fluorescence microscopy experiments performed in the surrogate Mycobacterium smegmatis ΔparB strain revealed that in contrast to wild type Mtb ParB, which formed subpolar foci similar to M. smegmatis ParB, phoshomimetic Mtb ParB was delocalized. Thus, our findings highlight a novel regulatory role of the different isoforms of ParB representing a molecular switch in localization and functioning of partitioning protein in Mycobacterium tuberculosis.

  18. Phosphorylation of Mycobacterium tuberculosis ParB participates in regulating the ParABS chromosome segregation system.

    Directory of Open Access Journals (Sweden)

    Grégory Baronian

    Full Text Available Here, we present for the first time that Mycobacterium tuberculosis ParB is phosphorylated by several mycobacterial Ser/Thr protein kinases in vitro. ParB and ParA are the key components of bacterial chromosome segregation apparatus. ParB is a cytosolic conserved protein that binds specifically to centromere-like DNA parS sequences and interacts with ParA, a weak ATPase required for its proper localization. Mass spectrometry identified the presence of ten phosphate groups, thus indicating that ParB is phosphorylated on eight threonines, Thr32, Thr41, Thr53, Thr110, Thr195, and Thr254, Thr300, Thr303 as well as on two serines, Ser5 and Ser239. The phosphorylation sites were further substituted either by alanine to prevent phosphorylation or aspartate to mimic constitutive phosphorylation. Electrophoretic mobility shift assays revealed a drastic inhibition of DNA-binding by ParB phosphomimetic mutant compared to wild type. In addition, bacterial two-hybrid experiments showed a loss of ParA-ParB interaction with the phosphomimetic mutant, indicating that phosphorylation is regulating the recruitment of the partitioning complex. Moreover, fluorescence microscopy experiments performed in the surrogate Mycobacterium smegmatis ΔparB strain revealed that in contrast to wild type Mtb ParB, which formed subpolar foci similar to M. smegmatis ParB, phoshomimetic Mtb ParB was delocalized. Thus, our findings highlight a novel regulatory role of the different isoforms of ParB representing a molecular switch in localization and functioning of partitioning protein in Mycobacterium tuberculosis.

  19. Funding Research Through the Online Partnership to Accelerate Research (OnPAR

    Directory of Open Access Journals (Sweden)

    Martin A. Dueñas, MPA

    2016-10-01

    Full Text Available OnPAR—the Online Partnership to Accelerate Research—seeks to provide a second opportunity for funding of high-quality, unfunded applications originally submitted to the National Institutes of Health and other national and international funding agencies. OnPAR will match applicable, unfunded applications with the research priorities of nongovernment organizations such as private biomedical foundations, pharmaceutical companies, venture capital funds, and other private funds. Funding organization members will review and make final funding decisions through a simple, 2-step process whereby applicants can submit public abstracts directly to OnPAR. If a member requests additional information, then, by invitation only, an applicant can submit their original unfunded application and their peer review summary statement. Advancing research discovery and drug development to improve clinical outcomes for patients afflicted with or at risk for disease is the primary goal of OnPAR. OnPAR invites the scientific community to fully participate in this new funding paradigm by submitting their National Institutes of Health public abstracts so that funding members can review and potentially support these high-quality, unfunded applications.

  20. Un « gouvernement des journalistes par le Pouvoir politique » par défaut ?

    Directory of Open Access Journals (Sweden)

    Matthieu Lardeau

    2013-12-01

    Full Text Available Cet article présente les interactions de deux mouvements concomitants apparusprincipalement dans les décennies 1950 à 1970 dans le champ de la presse française : d’un côté les initiatives – consécutives à la démarche pionnière, en 1951, de création de la première Société des journalistes (SDJ au sein du Monde – menées par les journalistes de rédactions de quotidiens pour créer des SDJ dont la destination peut aller jusqu’à gouverner les journaux; de l’autre côté, les « réponses » apportées par les Pouvoirs politique et public pour contenir ces initiatives visant à étendre le pouvoir des journalistes dans la gestion et la gouvernance de leurs journaux. Cette étude exploratoire repose principalement sur l’analyse de deux types de littérature, souvent déconsidérés ou négligés par le champ académique, en dépit de leur grande richesse : (1 la littérature professionnelle, ayant pour principaux auteurs les journalistes et managers de presse (Périer Daville, Boegner, Pigasse, etc., florissante depuis 1944 et singulièrement durant les décennies 1960 et 1970 ; (2 la littérature grise constituée notamment par des rapports publics rédigés par des institutions comme les services du Premier ministre (commissions Lindon de 1970 et Serisé de 1972, le Conseil économique et social, etc. Nos principaux résultats montrent que les propositions ou actions menées par les journalistes (1 restent le plus souvent inexploitées in concreto par les journalistes eux-mêmes; (2 entrent le plus souvent en opposition avec les politiques de nouveaux actionnaires ou directions de journaux et avec les projets des autorités politiques et publiques qui cherchent à encadrer l’autonomie de la profession journalistique pour mieux gouverner celle-ci ; (3 combien in fine les représentants des différents acteurs impliqués s’accordent pour contenir l’émergence d’un « gouvernement des journalistes » par les

  1. Law project modified by the Senate after urgency declaration relative to the electric and gas public utilities and to the power and gas companies; Projet de loi modifie par le Senat apres declaration d'urgence relatif au service public de l'electricite et du gaz et aux entreprises electriques et gazieres

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    This document is the modifications made by the French Senate after the first reading of the law project adopted by the House of Commons and relative to the change of status of the power and gas public utilities in the framework of the deregulation of European energy markets. This law changes the juridical status of the two state monopolies Electricite de France (EdF) and Gaz de France (GdF) into two anonymous companies and creates two additional companies for the management of the power and gas networks. It ensures also the transposition of the European directives from June 26, 2003 (2003/54/CE and 2003/55/CE). It contains some proper dispositions and modifies various existing French laws, in particular the law no. 46-628 from April 8, 1946 about the electricity and gas nationalization and the law no. 2000-108 from February 10, 2000 relative to the modernization and development of the electric public utility. The document lists the modifications made by the Senate article by article. (J.S.)

  2. [Ambroise Paré in French literature].

    Science.gov (United States)

    Dumaitre, P

    1995-01-01

    The 16th century by its passionate side has been the favourite one of authors of historical novels in which among the heroes of "cloak and dagger stories" appears sometime Ambroise Paré. Alexandre Dumas (the father) has shown him at the court of Charles IX in La Reine Margot (1845) where he does not however play a great role. On the contrary, Balzac in Le Martyr calviniste (1842) has given him a capital part close to the dying François II, whom he intended to trepanize but had to give up this idea as a consequence of the opposition of the queen-mother Catherine de Médicis. In the present century, Robert Merle in Paris ma bonne ville (Fortune de France, 3, 1980) shows Paré at the time of the Saint Barthélemy.

  3. Par Pond refill water quality sampling

    International Nuclear Information System (INIS)

    Koch, J.W. II; Martin, F.D.; Westbury, H.M.

    1996-08-01

    This study was designed to document anoxia and its cause in the event that the anoxia caused a fish kill. However, no fish kill was observed during this study, and dissolved oxygen and nutrient concentrations generally remained within the range expected for southeastern reservoirs. Par Pond water quality monitoring will continue during the second summer after refill as the aquatic macrophytes become reestablished and nutrients in the sediments are released to the water column

  4. Centromere pairing by a plasmid-encoded type I ParB protein

    DEFF Research Database (Denmark)

    Ringgaard, Simon; Löwe, Jan; Gerdes, Kenn

    2007-01-01

    The par2 locus of Escherichia coli plasmid pB171 encodes two trans-acting proteins, ParA and ParB, and two cis-acting sites, parC1 and parC2, to which ParB binds cooperatively. ParA is related to MinD and oscillates in helical structures and thereby positions ParB/parC-carrying plasmids regularly......, hence identifying the N terminus of ParB as a requirement for ParB-mediated centromere pairing. These observations suggest that centromere pairing is an important intermediate step in plasmid partitioning mediated by the common type I loci....

  5. Evaluation of the use of pectin among children living on the territories contaminated by cesium. Situation and critical analysis of publications; Evaluation de l'emploi de la pectine chez les enfants vivant sur les territoires contamines par le cesium. Etat de l'art et analyse critique des publications

    Energy Technology Data Exchange (ETDEWEB)

    Jourdain, J.R.; Dublineau, I.; Phan, G

    2005-07-01

    This report includes four parts. The first one gives the situation of knowledge on the biological effects of pectin in human nutrition and in case of exposure to heavy metals. The second part presents an analysis of publications devoted to biological effects of pectins in case of chronic intake of radioisotopes.The third part is a synthesis that gives the principal teaching of this analysis. The last part presents the propositions of I.R.S.N relative to future works and studies that it would be interesting to launch in order to complete the knowledge relative to the use of pectin in the case of chronic intake of radioisotopes. (N.C.)

  6. Project of law modified by the Senate relative to the electric and gas public utilities and to the electric and gas companies; Projet de loi modifie par le Senat relatif au service public de l'electricite et du gaz et aux entreprises electriques et gazieres

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    This project of law aims to adapt the electricity and gas sector to the new economical context of opening of the energy markets to competition. It gives to energy companies the internal organization base necessary to warrant a high level of service and a transparent and non-discriminatory access of third parties to transport and distribution networks. These evolutions will allow Electricite de France (EdF) and Gaz de France (GdF) companies to compete on equal terms with their European competitors. It confirms first the prime role of public utility of both companies and then transposes the dispositions of the European directives relative to the organization of EdF and GdF integrated companies. It foresees the creation of two daughter companies for the management of energy transport activities. The project of law foresees also the change of the status of EdF and GdF companies and the reform of the retirement pensions of the personnel. This report presents the modifications added by the Senate to the text of law adopted at first reading by the House of Commons. (J.S.)

  7. juin 2017 Pendent le dernier trimestre, nous nous sommes préparés ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Angela Wadeyua

    réaction rapide et l'altruisme ont permis de sauver le pays d'une épidémie catastrophique d'Ebola. Découvrez comment un programme de leadership stimulant mis sur pied par l'Université du Cap aide de jeunes chefs de file des secteurs public et privé en Afrique à utiliser le dialogue et le réseautage pour favoriser le ...

  8. Childhood Pars Planitis; Clinical Features and Outcomes

    Directory of Open Access Journals (Sweden)

    Homayoon Nikkhah

    2011-01-01

    Full Text Available Purpose: To evaluate the demographic and clinical features of childhood pars planitis, and to determine the therapeutic and visual outcomes of the disease. Methods: Medical records of pediatric patients (less than 16 years of age at diagnosis with pars planitis and at least 6 months of follow-up who were referred to Labbafinejad Medical Center, Tehran, Iran over a 22 year period were reviewed. Results: Overall, 117 eyes of 61 patients including 51 (83.6% male subjects were included. Mean age at the time of diagnosis was 7.8΁3.2 (range, 3-16 years. Mean best corrected visual acuity (BCVA was 0.88΁0.76 logMAR at presentation which improved to 0.39΁0.51 logMAR at final visit (P<0.001. Endotheliitis was present in 23 (19.6% eyes and was significantly more prevalent in subjects younger than 9 years (P=0.025. Cataract formation (41.9% and cystoid macular edema (19.7% were the most prevalent complications. Univariate regression analysis showed that better baseline visual acuity (OR=0.38, 95%CI 0.21-0.70, P=0.002, age older than 5 years at disease onset (OR=0.36, 95%CI 0.14-0.9, P=0.029, absence of endotheliitis (OR=0.39, 95%CI 0.15-0.99, P=0.047 and female gender (OR=3.77, 95%CI 1.03-13.93, P=0.046 were significantly associated with final BCVA of 20/40 or better. Conclusion: Childhood pars planitis was much more common among male subjects. Endotheliitis may be a sign of inflammation spillover and is more prevalent in younger patients. Visual prognosis is favorable in most patients with appropriate treatment.

  9. Mécanisme de l'usure par polissage des cylindres de moteurs diesel Bore Polishing Wear Mechanism in Diesel Engine Cylinders

    Directory of Open Access Journals (Sweden)

    Fayard J. C.

    2006-11-01

    Full Text Available Une méthode rapide et économique d'évaluation des lubrifiants et des combustibles vis-à-vis de l'usure par polissage des cylindres de moteurs diesel suralimentés a été mise au point sur moteur monocylindre de laboratoire dans le cadre d'une convention de recherche Société Nationale Elf Aquitaine - Institut Français du Pétrole (SNEA-IFP. Cette méthode référencée IFP-UP-4/80, permet également de juger de la tendance à la formation de dépôts et au gommage, de l'usure des segments et de la tendance à la consommation d'huile des lubrifiants. Elle est en bonne corrélation avec l'essai CEC-Ford Tornado et discrimine très bien les huiles de référence RL 47 et RL 48 du Conseil Européen de Coordination (CEC. Elle a permis l'étude du mécanisme de l'usure par polissage en recherchant l'influence de paramètres essentiels : - Constitution du lubrifiant : le phénomène est influencé par la nature de l'huile de base et par sa viscosité, par la quantité de polymères améliorant l'indice de viscosité et surtout par le choix des additifs détergents. En première approximation et pour des familles d'huiles homogènes, l'usure par polissage augmente lorsque la stabilité thermique de l'huile diminue. - Fonctionnement du moteur : le polissage croît très vite avec la charge du moteur à partir d'un certain seuil, son évolution en fonction du temps, observée par cotation endoscopique, présente une allure caractéristique en S, le polissage commence du côté poussée et en haut du cylindre. - Constitution du combustible : l'augmentation de la teneur en soufre du gazole diminue fortement l'usure par polissage provoquée par une huile réputée mauvaise sur ce plan mais est sans effet sur une bonne huile. - Etat de surface du cylindre : le prépolissage de la chemise par pierrage extrêmement fin ne conduit pas aux mêmes phénomènes que ceux observés lorsque la chemise est polie in situ dans le moteur en fonctionnement. En

  10. Dresses problems arising from hot-plant operation and their solution (1961); Les problemes vestimentaires poses par l'exploitation des installations actives et leurs solutions (1961)

    Energy Technology Data Exchange (ETDEWEB)

    Rodier, J; Bouzigues, H; Boutot, P [Commissariat a l' Energie Atomique, Centre de Production de Plutonium, Marcoule (France). Centre d' Etudes Nucleaires

    1961-07-01

    This article deals with effective methods to struggle radioactive contamination using rationally designed working clothes. The choice of the cloth is important and cotton, because of its absorbent properties constitutes an effective barrier to radioelements failing on its surface. Clothing the personnel of large nuclear industrial concerns is a big problem which can only be solved by carefully studied methods. The decontamination and washing of large amounts of clothes whose flow increases during periods of radio-active incidents have to be treated as are those operations in hospital laundering. Linen washing by the German counter-current method (the Sulzman system) is of great value because of the volume which can be treated and, more important, because of the small amount of liquid waste produced. Dry cleaning is certainly a method of the future and is even more economic than the preceding one. In 'active' laundries, the control of clothing for residual contamination can constitute a serious bottleneck in the production of clean clothing if automatic high-speed machines are not used. The risk to the operating personnel comes solely from contamination of the atmosphere and of the surfaces. Because of this, the plant must be considered as an active zone in which are handled several tens of millicuries of dangerous emitters and several micro- curies of plutonium daily. (authors) [French] Ce memoire traite des moyens efficaces de lutte contre la contamination radioactive que peuvent offrir des vetements de travail de conception rationnelle. Le choix du tissu est un element important et la fibre de coton, par ses proprietes absorbantes, constitue un excellent barrage aux radioelements deposes a sa surface. L'habillement du personnel des grands ensembles industriels de l'energie atomique est un gros probleme qui ne peut etre solutionne qu'avec des moyens soigneusement etudies. La decontamination et le lavage des grandes quantites de vetements renouveles a cadence

  11. Dresses problems arising from hot-plant operation and their solution (1961); Les problemes vestimentaires poses par l'exploitation des installations actives et leurs solutions (1961)

    Energy Technology Data Exchange (ETDEWEB)

    Rodier, J.; Bouzigues, H.; Boutot, P. [Commissariat a l' Energie Atomique, Centre de Production de Plutonium, Marcoule (France). Centre d' Etudes Nucleaires

    1961-07-01

    This article deals with effective methods to struggle radioactive contamination using rationally designed working clothes. The choice of the cloth is important and cotton, because of its absorbent properties constitutes an effective barrier to radioelements failing on its surface. Clothing the personnel of large nuclear industrial concerns is a big problem which can only be solved by carefully studied methods. The decontamination and washing of large amounts of clothes whose flow increases during periods of radio-active incidents have to be treated as are those operations in hospital laundering. Linen washing by the German counter-current method (the Sulzman system) is of great value because of the volume which can be treated and, more important, because of the small amount of liquid waste produced. Dry cleaning is certainly a method of the future and is even more economic than the preceding one. In 'active' laundries, the control of clothing for residual contamination can constitute a serious bottleneck in the production of clean clothing if automatic high-speed machines are not used. The risk to the operating personnel comes solely from contamination of the atmosphere and of the surfaces. Because of this, the plant must be considered as an active zone in which are handled several tens of millicuries of dangerous emitters and several micro- curies of plutonium daily. (authors) [French] Ce memoire traite des moyens efficaces de lutte contre la contamination radioactive que peuvent offrir des vetements de travail de conception rationnelle. Le choix du tissu est un element important et la fibre de coton, par ses proprietes absorbantes, constitue un excellent barrage aux radioelements deposes a sa surface. L'habillement du personnel des grands ensembles industriels de l'energie atomique est un gros probleme qui ne peut etre solutionne qu'avec des moyens soigneusement etudies. La decontamination et le lavage des grandes quantites de vetements

  12. Accouchement par forceps: indications et pronostic materno-foetal ...

    African Journals Online (AJOL)

    L'accouchement par voie basse, peut être parfois compromis par des facteurs maternels, foetaux ou materno-foetaux nécessitant des moyens thérapeutiques comme le forceps pour achever l'accouchement par voie naturelle. Le forceps, une méthode qui n'est pas sans risque pour la mère et le nouveau-né. Nous avons ...

  13. Analyse des kérosènes et des gas oils moyens par spectrométrie de masse à moyenne résolution Analysis of Kerosenes and Middle Distillates by Medium-Resolution Mass Spectrometry

    Directory of Open Access Journals (Sweden)

    Castex H.

    2006-11-01

    Full Text Available Une méthode d'analyse par spectrométrie de masse des kérosènes et des distillats moyens dérivée de la norme ASTM D2425, a été développée. Elle utilise le même principe de calcul du carbone moyen pour déterminer le choix des matrices appropriées. Mais elle opère à moyenne résolution, effectuant ainsi le tri des différentes masses exactes d'hydrocarbures, composés soufrés et oxygénés et évitant de ce fait toute séparation préalable par chromatographie liquide (ASTM D2 549 . Les valeurs des matrices ont été modifiées en conséquence et le calcul du carbone moyen adapté à l'étude des coupes étroites et larges. A mass-spectrometry analysis method derived from the ASTM D2425 standard has been developed for kerosenes and middle distillates (185-345°C. It uses the same principle for calculating the mean carbon value to determine the appropriate matrices. But it works with medium reso-lution so as to sort out the different exact masses of hydrocarbons, sulfur and oxygenated compounds, thus avoiding any prior separation by liquid chromatography (ASTM D2549. Therefore, the matrix values have been modified, and the calculation of the mean carbon value has been adapted for analyzing narrow and wide distillation cuts.

  14. PAR1 activation affects the neurotrophic properties of Schwann cells.

    Science.gov (United States)

    Pompili, Elena; Fabrizi, Cinzia; Somma, Francesca; Correani, Virginia; Maras, Bruno; Schininà, Maria Eugenia; Ciraci, Viviana; Artico, Marco; Fornai, Francesco; Fumagalli, Lorenzo

    2017-03-01

    Protease-activated receptor-1 (PAR1) is the prototypic member of a family of four G-protein-coupled receptors that signal in response to extracellular proteases. In the peripheral nervous system, the expression and/or the role of PARs are still poorly investigated. High PAR1 mRNA expression was found in the rat dorsal root ganglia and the signal intensity of PAR1 mRNA increased in response to sciatic nerve transection. In the sciatic nerve, functional PAR1 receptor was reported at the level of non-compacted Schwann cell myelin microvilli of the nodes of Ranvier. Schwann cells are the principal population of glial cells of the peripheral nervous system which myelinate axons playing an important role during axonal regeneration and remyelination. The present study was undertaken in order to determine if the activation of PAR1 affects the neurotrophic properties of Schwann cells. Our results suggest that the stimulation of PAR1 could potentiate the Schwann cell ability to favour nerve regeneration. In fact, the conditioned medium obtained from Schwann cell cultures challenged with a specific PAR1 activating peptide (PAR1 AP) displays increased neuroprotective and neurotrophic properties with respect to the culture medium from untreated Schwann cells. The proteomic analysis of secreted proteins in untreated and PAR1 AP-treated Schwann cells allowed the identification of factors differentially expressed in the two samples. Some of them (such as macrophage migration inhibitory factor, matrix metalloproteinase-2, decorin, syndecan 4, complement C1r subcomponent, angiogenic factor with G patch and FHA domains 1) appear to be transcriptionally regulated after PAR1 AP treatment as shown by RT-PCR. Copyright © 2017 Elsevier Inc. All rights reserved.

  15. Taare Zameen Par and dyslexic savants.

    Science.gov (United States)

    Chakravarty, Ambar

    2009-04-01

    The film Taare Zameen Par (Stars upon the Ground) portrays the tormented life at school and at home of a child with dyslexia and his eventual success after his artistic talents are discovered by his art teacher at the boarding school. The film hints at a curious neurocognitive phenomenon of creativity in the midst of language disability, as exemplified in the lives of people like Leonardo da Vinci and Albert Einstein, both of whom demonstrated extraordinary creativity even though they were probably affected with developmental learning disorders. It has been hypothesized that a developmental delay in the dominant hemisphere most likely 'disinhibits' the nondominant parietal lobe, unmasking talents-artistic or otherwise-in some such individuals. It has been suggested that, in remedial training, children with learning disorders be encouraged to develop such hidden talents to full capacity, rather than be subjected to the usual overemphasis on the correction of the disturbed coded symbol operations.

  16. Soudage de bois feuillus par friction rotationnelle

    OpenAIRE

    Belleville, Benoît

    2012-01-01

    Les différentes colles utilisées actuellement par l’industrie du meuble au Canada nécessitent des temps de polymérisation constituant un goulot dans la production des meubles et limitant l’atteinte de la production unitaire. Ces adhésifs synthétiques généralement issus de la pétrochimie nécessitent énormément d’énergie lors de leur confection. L’utilisation de connecteurs métalliques ou plastiques, quant à elle, limite les phases de découpage et sablage subséquentes. La présence d’adhésifs et...

  17. Problems and energy choices in Burkina Faso[Energie ; Economie domestique ; Bois de feu ; Produits petroliers ; Legislation fonciere ; Electricite]; Burkina : Problemes et choix energetiques

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1986-01-15

    This document is about the evaluation of the energy sector in Burkina Faso. It reports about the main issues of energy: poverty of the households, the lack of fund to finance the sector, desertification...The main resources of energy are firewood, fuel and electricity. The energy needs of Burkina Faso are related to the cooking of food, with liquid fuels intended for the railway transport and fuels used in industry and for the production of electricity. With regard to the transport sector, there is currently no possibility of substitution for the fuel, except the use of ethanol diluted in the gasoline. At the industrial level, agro-industrial, bagasse and the other residues constitute right now the independent source of energy for the production of industrial heat as well as for that of electricity. For the public network of electricity supply, the production rests exclusively on diesel power stations. Regarding the immense needs for its populations in energy, Burkina has only very limited resources. The biomass used for domestic needs cannot continuously ensure the households with the necessary energy supply for food cooking. As for the agro-industrial residues, they cannot reduce the industrial consumption of fuels. There are also hydraulic resources whose conscientious exploitation could contribute to decrease the fuel consumption in terms of electricity. In sum, it would be necessary to improve the regulation as regards firewood supply, to promote the use of improved hearths with wood, to plan the fuel supplies and to assist the SONABEL in the electric production capacities reinforcement of its fuel-based power stations. [French] Ce document traite de l evaluation du secteur de l energie au Burkina. Il fait etat des principaux problemes energetiques : pauvrete des menages, manque de financement dans le secteur, desertification... Les principales ressources energetiques sont le bois de feu, les produits petroliers et l electricite. Les besoins energetiques du

  18. TMS suppression of right pars triangularis, but not pars opercularis, improves naming in aphasia

    Science.gov (United States)

    Naeser, Margaret A.; Martin, Paula I.; Theoret, Hugo; Kobayashi, Masahito; Fregni, Felipe; Nicholas, Marjorie; Tormos, Jose M.; Steven, Megan S.; Baker, Errol H.; Pascual-Leone, Alvaro

    2011-01-01

    This study sought to discover if an optimum 1 cm2 area in the non-damaged right hemisphere (RH) was present, which could temporarily improve naming in chronic, nonfluent aphasia patients when suppressed with repetitive transcranial magnetic stimulation (rTMS). Ten minutes of slow, 1 Hz rTMS was applied to suppress different RH ROIs in eight aphasia cases. Picture naming and response time (RT) were examined before, and immediately after rTMS. In aphasia patients, suppression of right pars triangularis (PTr) led to significant increase in pictures named, and significant decrease in RT. Suppression of right pars opercularis (POp), however, led to significant increase in RT, but no change in number of pictures named. Eight normals named all pictures correctly; similar to aphasia patients, RT significantly decreased following rTMS to suppress right PTr, versus right POp. Differential effects following suppression of right PTr versus right POp suggest different functional roles for these regions. PMID:21864891

  19. ParABS system in chromosome partitioning in the bacterium Myxococcus xanthus.

    Directory of Open Access Journals (Sweden)

    Antonio A Iniesta

    Full Text Available Chromosome segregation is an essential cellular function in eukaryotic and prokaryotic cells. The ParABS system is a fundamental player for a mitosis-like process in chromosome partitioning in many bacterial species. This work shows that the social bacterium Myxococcus xanthus also uses the ParABS system for chromosome segregation. Its large prokaryotic genome of 9.1 Mb contains 22 parS sequences near the origin of replication, and it is shown here that M. xanthus ParB binds preferentially to a consensus parS sequence in vitro. ParB and ParA are essential for cell viability in M. xanthus as in Caulobacter crescentus, but unlike in many other bacteria. Absence of ParB results in anucleate cells, chromosome segregation defects and loss of viability. Analysis of ParA subcellular localization shows that it clusters at the poles in all cells, and in some, in the DNA-free cell division plane between two chromosomal DNA masses. This ParA localization pattern depends on ParB but not on FtsZ. ParB inhibits the nonspecific interaction of ParA with DNA, and ParA colocalizes with chromosomal DNA only when ParB is depleted. The subcellular localization of ParB suggests a single ParB-parS complex localized at the edge of the nucleoid, next to a polar ParA cluster, with a second ParB-parS complex migrating after the replication of parS takes place to the opposite nucleoid edge, next to the other polar ParA cluster.

  20. Concerning the dynamic instability of actin homolog ParM

    International Nuclear Information System (INIS)

    Popp, David; Yamamoto, Akihiro; Iwasa, Mitsusada; Narita, Akihiro; Maeda, Kayo; Maeda, Yuichiro

    2007-01-01

    Using in vitro TIRF- and electron-microscopy, we reinvestigated the dynamics of native ParM, a prokaryotic DNA segregation protein and actin homolog. In contrast to a previous study, which used a cysteine ParM mutant, we find that the polymerization process of wild type ATP-ParM filaments consists of a polymerization phase and a subsequent steady state phase, which is dynamically unstable, like that of microtubules. We find that the apparent bidirectional polymerization of ParM, is not due to the intrinsic nature of this filament, but results from ParM forming randomly oriented bundles in the presence of crowding agents. Our results imply, that in the bacterium, ParM filaments spontaneously form bipolar bundles. Due to their intrinsic dynamic instability, ParM bundles can efficiently 'search' the cytoplasmic lumen for DNA, bind it equally well at the bipolar ends and segregate it approximately symmetrically, by the insertion of ParM subunits at either end

  1. The protein kinase SIK downregulates the polarity protein Par3

    DEFF Research Database (Denmark)

    Vanlandewijck, Michael; Dadras, Mahsa Shahidi; Lomnytska, Marta

    2018-01-01

    on Par3. Functionally, this mechanism impacts on tight junction downregulation. Furthermore, SIK contributes to the loss of epithelial polarity and examination of advanced and invasive human cancers of diverse origin displayed high levels of SIK expression and a corresponding low expression of Par3...

  2. Recombination in the human Pseudoautosomal region PAR1.

    Directory of Open Access Journals (Sweden)

    Anjali G Hinch

    2014-07-01

    Full Text Available The pseudoautosomal region (PAR is a short region of homology between the mammalian X and Y chromosomes, which has undergone rapid evolution. A crossover in the PAR is essential for the proper disjunction of X and Y chromosomes in male meiosis, and PAR deletion results in male sterility. This leads the human PAR with the obligatory crossover, PAR1, to having an exceptionally high male crossover rate, which is 17-fold higher than the genome-wide average. However, the mechanism by which this obligatory crossover occurs remains unknown, as does the fine-scale positioning of crossovers across this region. Recent research in mice has suggested that crossovers in PAR may be mediated independently of the protein PRDM9, which localises virtually all crossovers in the autosomes. To investigate recombination in this region, we construct the most fine-scale genetic map containing directly observed crossovers to date using African-American pedigrees. We leverage recombination rates inferred from the breakdown of linkage disequilibrium in human populations and investigate the signatures of DNA evolution due to recombination. Further, we identify direct PRDM9 binding sites using ChIP-seq in human cells. Using these independent lines of evidence, we show that, in contrast with mouse, PRDM9 does localise peaks of recombination in the human PAR1. We find that recombination is a far more rapid and intense driver of sequence evolution in PAR1 than it is on the autosomes. We also show that PAR1 hotspot activities differ significantly among human populations. Finally, we find evidence that PAR1 hotspot positions have changed between human and chimpanzee, with no evidence of sharing among the hottest hotspots. We anticipate that the genetic maps built and validated in this work will aid research on this vital and fascinating region of the genome.

  3. Transports and the energy: structural choices and environmental constraints. What is the role of the public authorities?; Les transports et l'energie: les choix structuraux et les contraintes environnementales. Quel role pour la puissance publique?

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-12-15

    The framework of this report focused on mainly France, the goods transports and the urban transports, offering a large place to the institutional aspects. The two first parts of the report are devoted to the state of the art and to a diagnostic of the system energy-transport and of the institutional device in France. the third part concludes that a voluntary action will ne necessary. Many propositions are provided around scenari which reveal different society choices. (A.L.B.)

  4. Transports and the energy: structural choices and environmental constraints. What is the role of the public authorities?; Les transports et l'energie: les choix structuraux et les contraintes environnementales. Quel role pour la puissance publique?

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-12-15

    The framework of this report focused on mainly France, the goods transports and the urban transports, offering a large place to the institutional aspects. The two first parts of the report are devoted to the state of the art and to a diagnostic of the system energy-transport and of the institutional device in France. the third part concludes that a voluntary action will ne necessary. Many propositions are provided around scenari which reveal different society choices. (A.L.B.)

  5. Detection de la fin de la compaction des anodes par le son

    Science.gov (United States)

    Sanogo, Bazoumana

    ete le lieu de tests finaux a l'usine en fabriquant des anodes avec differents criteres (variation du temps de compaction, taux de brai, arret manuel du compacteur, variation de la pression des ballons du haut du compacteur). Ces anodes ont ete ensuite analysees au laboratoire a l'UQAC. En parallele a ces travaux precites, l'amelioration de l'application d'analyse du son a ete faite avec le choix des parametres d'analyse et leur standardisation. Les resultats des premiers tests au laboratoire et ceux de la campagne de juin 2014 ont montre que la formation des anodes se fait suivant trois etapes : rearrangement des particules et du brai, compaction et consolidation et enfin la finition. Ces travaux ont montre en outre que le temps de compaction joue un role tres important dans la definition des proprietes finales des anodes. Ainsi, en plus du type de brai, du taux de brai et du type de coke, il faut tenir compte du temps de sur-compaction et de sous-compaction. En effet, ceci a ete demontre a travers les deux validations qui ont ete realisees. Les resultats de la caracterisation des echantillons (venant des anodes de la campagne de decembre 2015) ont montre qu'une anode compactee a un temps optimal acquiert une bonne resistance a la compression et sa resistivite electrique baisse. En outre, on note que le temps de compaction dans notre cas a baisse legerement avec l'augmentation de la pression des ballons de haut du vibrocompacteur. Ce qui a eu pour effet d'augmenter la densite crue de l'anode. Toutefois, il faut s'abstenir de generaliser ce constat car le nombre d'anodes testees est faible dans notre cas. Par ailleurs, cette etude montre que le temps necessaire pour le formage d'une anode croit avec l'augmentation du taux de brai et baisse legerement avec l'augmentation de la pression des ballons. (Abstract shortened by ProQuest.).

  6. The influence of xenon poisoning in high-flux reactors on the choice of control rod speeds (1961); Influence de l'empoisonnement xenon dans les piles a haut flux sur le choix de la vitesse des barres de controle (1961)

    Energy Technology Data Exchange (ETDEWEB)

    Furet, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1961-07-01

    - The general laws are restated concerning the changes in xenon and iodine concentrations in thermal neutron reactors, assuming an uniform neutron flux distribution in the core. It is shown how the evolution in the xenon poisoning influences the selection of the control rod speed, at start-up. Certain simple methods of calculation are developed making it possible to resolve the problem of the choice of this speed in the case where the xenon poisoning is taken into account. (author) [French] - On rappelle les lois generales relatives aux evolutions de concentration xenon et iode dans les piles atomiques a neutrons thermiques lorsqu'on suppose une repartition uniforme du flux de neutrons dans le coeur. On montre comment l'evolution de l'empoisonnement xenon influe sur le choix de la vitesse des barres de controle en periode de demarrage. On developpe certaines methodes de calculs simples permettant de resoudre le probleme du choix de la vitesse des barres de controle, dans le cas ou l'on tient compte de l'empoisonnement xenon. (auteur)

  7. PARs for combustible gas control in advanced light water reactors

    International Nuclear Information System (INIS)

    Hosler, J.; Sliter, G.

    1997-01-01

    This paper discusses the progress being made in the United States to introduce passive autocatalytic recombiner (PAR) technology as a cost-effective alternative to electric recombiners for controlling combustible gas produced in postulated accidents in both future Advanced Light Water Reactors (ALWRs) and certain U. S. operating nuclear plants. PARs catalytically recombine hydrogen and oxygen, gradually producing heat and water vapor. They have no moving parts and are self-starting and self-feeding, even under relatively cold and wet containment conditions. Buoyancy of the hot gases they create sets up natural convective flow that promotes mixing of combustible gases in a containment. In a non-inerted ALWR containment, two approaches each employing a combination of PARs and igniters are being considered to control hydrogen in design basis and severe accidents. In pre-inerted ALWRs, PARs alone control radiolytic oxygen produced in either accident type. The paper also discusses regulatory feedback regarding these combustible gas control approaches and describes a test program being conducted by the Electric Power Research Institute (EPRI) and Electricite de France (EdF) to supplement the existing PAR test database with performance data under conditions of interest to U.S. plants. Preliminary findings from the EPRI/EdF PAR model test program are included. Successful completion of this test program and confirmatory tests being sponsored by the U. S. NRC are expected to pave the way for use of PARs in ALWRs and operating plants. (author)

  8. uPAR as anti-cancer target

    DEFF Research Database (Denmark)

    Lund, Ida K; Illemann, Martin; Thurison, Tine

    2011-01-01

    , and a potential diagnostic and predictive impact of the different uPAR forms has been reported. Hence, pericellular proteolysis seems to be a suitable target for anti-cancer therapy and numerous approaches have been pursued. Targeting of this process may be achieved by preventing the binding of uPA to u...... using mouse monoclonal antibodies (mAbs) against mouse uPA or uPAR. These reagents will target uPA and uPAR in both stromal cells and cancer cells, and their therapeutic potential can now be assessed in syngenic mouse cancer models....

  9. Limnological database for Par Pond: 1959 to 1980

    International Nuclear Information System (INIS)

    Tilly, L.J.

    1981-03-01

    A limnological database for Par Pond, a cooling reservoir for hot reactor effluent water at the Savannah River Plant, is described. The data are derived from a combination of research and monitoring efforts on Par Pond since 1959. The approximately 24,000-byte database provides water quality, primary productivity, and flow data from a number of different stations, depths, and times during the 22-year history of the Par Pond impoundment. The data have been organized to permit an interpretation of the effects of twenty years of cooling system operations on the structure and function of an aquatic ecosystem

  10. Protease-activated receptor (PAR2, but not PAR1, is involved in collateral formation and anti-inflammatory monocyte polarization in a mouse hind limb ischemia model.

    Directory of Open Access Journals (Sweden)

    Lisa G van den Hengel

    Full Text Available AIMS: In collateral development (i.e. arteriogenesis, mononuclear cells are important and exist as a heterogeneous population consisting of pro-inflammatory and anti-inflammatory/repair-associated cells. Protease-activated receptor (PAR1 and PAR2 are G-protein-coupled receptors that are both expressed by mononuclear cells and are involved in pro-inflammatory reactions, while PAR2 also plays a role in repair-associated responses. Here, we investigated the physiological role of PAR1 and PAR2 in arteriogenesis in a murine hind limb ischemia model. METHODS AND RESULTS: PAR1-deficient (PAR1-/-, PAR2-deficient (PAR2-/- and wild-type (WT mice underwent femoral artery ligation. Laser Doppler measurements revealed reduced post-ischemic blood flow recovery in PAR2-/- hind limbs when compared to WT, while PAR1-/- mice were not affected. Upon ischemia, reduced numbers of smooth muscle actin (SMA-positive collaterals and CD31-positive capillaries were found in PAR2-/- mice when compared to WT mice, whereas these parameters in PAR1-/- mice did not differ from WT mice. The pool of circulating repair-associated (Ly6C-low monocytes and the number of repair-associated (CD206-positive macrophages surrounding collaterals in the hind limbs were increased in WT and PAR1-/- mice, but unaffected in PAR2-/- mice. The number of repair-associated macrophages in PAR2-/- hind limbs correlated with CD11b- and CD115-expression on the circulating monocytes in these animals, suggesting that monocyte extravasation and M-CSF-dependent differentiation into repair-associated cells are hampered. CONCLUSION: PAR2, but not PAR1, is involved in arteriogenesis and promotes the repair-associated response in ischemic tissues. Therefore, PAR2 potentially forms a new pro-arteriogenic target in coronary artery disease (CAD patients.

  11. Novel role for proteinase-activated receptor 2 (PAR2) in membrane trafficking of proteinase-activated receptor 4 (PAR4).

    Science.gov (United States)

    Cunningham, Margaret R; McIntosh, Kathryn A; Pediani, John D; Robben, Joris; Cooke, Alexandra E; Nilsson, Mary; Gould, Gwyn W; Mundell, Stuart; Milligan, Graeme; Plevin, Robin

    2012-05-11

    Proteinase-activated receptors 4 (PAR(4)) is a class A G protein-coupled receptor (GPCR) recognized through the ability of serine proteases such as thrombin and trypsin to mediate receptor activation. Due to the irreversible nature of activation, a fresh supply of receptor is required to be mobilized to the cell surface for responsiveness to agonist to be sustained. Unlike other PAR subtypes, the mechanisms regulating receptor trafficking of PAR(4) remain unknown. Here, we report novel features of the intracellular trafficking of PAR(4) to the plasma membrane. PAR(4) was poorly expressed at the plasma membrane and largely retained in the endoplasmic reticulum (ER) in a complex with the COPI protein subunit β-COP1. Analysis of the PAR(4) protein sequence identified an arginine-based (RXR) ER retention sequence located within intracellular loop-2 (R(183)AR → A(183)AA), mutation of which allowed efficient membrane delivery of PAR(4). Interestingly, co-expression with PAR(2) facilitated plasma membrane delivery of PAR(4), an effect produced through disruption of β-COP1 binding and facilitation of interaction with the chaperone protein 14-3-3ζ. Intermolecular FRET studies confirmed heterodimerization between PAR(2) and PAR(4). PAR(2) also enhanced glycosylation of PAR(4) and activation of PAR(4) signaling. Our results identify a novel regulatory role for PAR(2) in the anterograde traffic of PAR(4). PAR(2) was shown to both facilitate and abrogate protein interactions with PAR(4), impacting upon receptor localization and cell signal transduction. This work is likely to impact markedly upon the understanding of the receptor pharmacology of PAR(4) in normal physiology and disease.

  12. NOTRE ROUMANITÉ. CHOIX D’INTERPRÉTATIONS

    Directory of Open Access Journals (Sweden)

    Ileana TĂNASE

    2012-05-01

    Full Text Available To interpret a text means, under certain conditions, to simply iterate it with no personal contribution, or, in the terms of an already widely accepted expression, the best exegesis is the text itself. The interpretation can prejudice the chosen text by virtue of the cultural memory of the interpreter, tempted to place it at its intersection with other texts: thus, it will refer it to a text more or less different from the one concerned. This conclusion was also reached by those theoreticians of language who consider that ‘the only way of remaining absolutely true to a text is to repeat it’. It is from the perspective of this theory that, in the present article, I have approached interpretation as the reiteration of a text about our Romanian character, selected from an ampler text of Alexandru Paleologu. What allowed such an approach is the fact that the text reveals what any Romanian, at a certain moment, would say about himself, his personal or national history. About the condition of being Romanian.

  13. Choix langagiers dans la capitale du Nunavut

    Directory of Open Access Journals (Sweden)

    Louis-Jacques Dorais

    2003-06-01

    Full Text Available Abstract This article describes some elements of the linguistic behaviour of Inuit living in Iqaluit, the capital of the new territory of Nunavut. By observing linguistic interaction in 45 households and interviewing 50 Inuit adults from Iqaluit, we elucidate the nature of language choice (between Inuktitut and English with regards to various categories of interlocutors: parents, children, spouse, brothers and sisters, friends, co-workers. These choices showthe prevalence of bilingualism among speakers under 50 years of age as well as the importance of Inuktitut, which is the language of preference for addressing young children and elders and for discussing specially valued topics. It may be concluded that the Inuit in Iqaluit live in a situation of diglossia, but that this diglossia is moderated by the high value attributed to Inuktitut as a basic element and marker of Inuit identity.

  14. Le choix de l'excellence

    CERN Document Server

    Collins, Jim

    2012-01-01

    Dix ans après le succès mondial de De la performance à l'excellence (Good to Great), Jim Collins et son associé Morten T. Hansen s'interrogent ici sur la nature de l excellence en période d incertitude. Pourquoi, dans un contexte chaotique, certaines entreprises sont florissantes et d autres non ? Comment, en ces temps troublés, réussir à diriger et vaincre l adversité pour dominer son marché ? La chance peut-elle sérieusement être envisagée comme un facteur de réussite ? À l issue d un programme de recherche ambitieux et rigoureux qui a duré neuf ans, les auteurs exposent dans cet ouvrage les nouveaux principes pour bâtir une entreprise réellement excellente. Leurs conclusions sont, comme toujours, étonnantes. Ils soulignent notamment que la course à l innovation n est pas toujours la meilleure voie à suivre, que discipline et créativité peuvent aller de concert et que malgré le changement permanent, les meilleures décisions sont rarement prises dans l urgence. Quant aux leaders, on...

  15. Choix d'un modèle de pyrolyse ménagée du bois à l'échelle de la microparticule en vue de la modélisation macroscopique

    OpenAIRE

    Rousset , Patrick; Turner , Ian; Donnot , Andre; Perre , Patrick

    2006-01-01

    Par définition la pyrolyse ménagée du bois est la décomposition physique et chimique de matières organiques sous l'action de la chaleur et en absence d'oxygène. Comprendre ce phénomène passe d'abord par l'identification des mécanismes réactionnels et la détermination des paramètres cinétiques mis en jeu lors de la dégradation thermique du bois et de ses constituants majeurs, c'est-à-dire cellulose, hémicelluloses et lignines. La richesse et la diversité des résultats issus de la littérature s...

  16. Positron Accumulator Ring (PAR) power supply

    International Nuclear Information System (INIS)

    Fathizadeh, M.

    1995-01-01

    The Positron Accumulator Ring (PAR) consists of 8 dipole magnets connected in series. These magnets are energized via one 12-pulse dc power supply. The power supply consists of four phase controlled half-wave wye group converters. Each of the two half-wave converters are connected through an interphase transformer to obtain a full-wave converter with 120 degrees conduction. The input voltage for these two half-wave converters are 180 degrees apart. The two full-wave converters are connected in parallel through a third interphase transformer. This type of connection of the converters not only provides the required output current, it also improves the input power factor of the power supply. The output of the wye group converters is filtered through a passive L-R-C filter to reduce the ripple content of the output current. At low current values of the power supply the current ripple is high, thus a large filter is needed, which adds to the cost of the power supply, however at high output current levels, the current ripple is less severe. The large size of the filter can be reduced by adding an anti-parallel rectifier diode(D1) to the output of the power supply. A freewheeling diode(D2) is connected before the choke to circulate the current once the power supply is turned off. In order to measure the current in the magnet a high precision, low drift, zero flux current transductor is used. This transductor senses the magnet current which provides a feedback signal to control the gating of the converter's thyristors. A true 14 bit Digital to Analog Converter (DAC) is programmed by the control computer for the required current value, providing a reference for the current regulator. Fast correction of the line transients is provided by a relatively fast voltage loop controlled by a high gain slow response current loop

  17. First-in-human uPAR PET

    DEFF Research Database (Denmark)

    Persson, Morten; Skovgaard, Dorthe; Brandt-Larsen, Malene

    2015-01-01

    A first-in-human clinical trial with Positron Emission Tomography (PET) imaging of the urokinase-type plasminogen activator receptor (uPAR) in patients with breast, prostate and bladder cancer, is described. uPAR is expressed in many types of human cancers and the expression is predictive...... for targeted molecular imaging with PET. The safety, pharmacokinetic, biodistribution profile and radiation dosimetry after a single intravenous dose of (64)Cu-DOTA-AE105 were assessed by serial PET and computed tomography (CT) in 4 prostate, 3 breast and 3 bladder cancer patients. Safety assessment...... of invasion, metastasis and indicates poor prognosis. uPAR PET imaging therefore holds promise to be a new and innovative method for improved cancer diagnosis, staging and individual risk stratification. The uPAR specific peptide AE105 was conjugated to the macrocyclic chelator DOTA and labeled with (64)Cu...

  18. Peptide-Based Optical uPAR Imaging for Surgery

    DEFF Research Database (Denmark)

    Juhl, Karina; Christensen, Anders; Persson, Morten

    2016-01-01

    Near infrared intra-operative optical imaging is an emerging technique with clear implications for improved cancer surgery by enabling a more distinct delineation of the tumor margins during resection. This modality has the potential to increase the number of patients having a curative radical...... tumor resection. In the present study, a new uPAR-targeted fluorescent probe was developed and the in vivo applicability was evaluated in a human xenograft mouse model. Most human carcinomas express high level of uPAR in the tumor-stromal interface of invasive lesions and uPAR is therefore considered...... an ideal target for intra-operative imaging. Conjugation of the flourophor indocyanine green (ICG) to the uPAR agonist (AE105) provides an optical imaging ligand with sufficiently high receptor affinity to allow for a specific receptor targeting in vivo. For in vivo testing, human glioblastoma xenograft...

  19. Contribution de la tomographie par coherence optique au diagnostic ...

    African Journals Online (AJOL)

    Contribution de la tomographie par coherence optique au diagnostic de la neuropathie optique toxique. C.O.A. Abouki, S Alamou, C.R.A. Assavedo, L Odoulami-Yehouessi, I Sounouvou, S Hounnou-Tchabi ...

  20. Analysis of ParB-centromere interactions by multiplex SPR imaging reveals specific patterns for binding ParB in six centromeres of Burkholderiales chromosomes and plasmids.

    Directory of Open Access Journals (Sweden)

    Flavien Pillet

    Full Text Available Bacterial centromeres-also called parS, are cis-acting DNA sequences which, together with the proteins ParA and ParB, are involved in the segregation of chromosomes and plasmids. The specific binding of ParB to parS nucleates the assembly of a large ParB/DNA complex from which ParA-the motor protein, segregates the sister replicons. Closely related families of partition systems, called Bsr, were identified on the chromosomes and large plasmids of the multi-chromosomal bacterium Burkholderia cenocepacia and other species from the order Burkholeriales. The centromeres of the Bsr partition families are 16 bp palindromes, displaying similar base compositions, notably a central CG dinucleotide. Despite centromeres bind the cognate ParB with a narrow specificity, weak ParB-parS non cognate interactions were nevertheless detected between few Bsr partition systems of replicons not belonging to the same genome. These observations suggested that Bsr partition systems could have a common ancestry but that evolution mostly erased the possibilities of cross-reactions between them, in particular to prevent replicon incompatibility. To detect novel similarities between Bsr partition systems, we have analyzed the binding of six Bsr parS sequences and a wide collection of modified derivatives, to their cognate ParB. The study was carried out by Surface Plasmon Resonance imaging (SPRi mulitplex analysis enabling a systematic survey of each nucleotide position within the centromere. We found that in each parS some positions could be changed while maintaining binding to ParB. Each centromere displays its own pattern of changes, but some positions are shared more or less widely. In addition from these changes we could speculate evolutionary links between these centromeres.

  1. Analysis of ParB-centromere interactions by multiplex SPR imaging reveals specific patterns for binding ParB in six centromeres of Burkholderiales chromosomes and plasmids.

    Science.gov (United States)

    Pillet, Flavien; Passot, Fanny Marie; Pasta, Franck; Anton Leberre, Véronique; Bouet, Jean-Yves

    2017-01-01

    Bacterial centromeres-also called parS, are cis-acting DNA sequences which, together with the proteins ParA and ParB, are involved in the segregation of chromosomes and plasmids. The specific binding of ParB to parS nucleates the assembly of a large ParB/DNA complex from which ParA-the motor protein, segregates the sister replicons. Closely related families of partition systems, called Bsr, were identified on the chromosomes and large plasmids of the multi-chromosomal bacterium Burkholderia cenocepacia and other species from the order Burkholeriales. The centromeres of the Bsr partition families are 16 bp palindromes, displaying similar base compositions, notably a central CG dinucleotide. Despite centromeres bind the cognate ParB with a narrow specificity, weak ParB-parS non cognate interactions were nevertheless detected between few Bsr partition systems of replicons not belonging to the same genome. These observations suggested that Bsr partition systems could have a common ancestry but that evolution mostly erased the possibilities of cross-reactions between them, in particular to prevent replicon incompatibility. To detect novel similarities between Bsr partition systems, we have analyzed the binding of six Bsr parS sequences and a wide collection of modified derivatives, to their cognate ParB. The study was carried out by Surface Plasmon Resonance imaging (SPRi) mulitplex analysis enabling a systematic survey of each nucleotide position within the centromere. We found that in each parS some positions could be changed while maintaining binding to ParB. Each centromere displays its own pattern of changes, but some positions are shared more or less widely. In addition from these changes we could speculate evolutionary links between these centromeres.

  2. Prise en charge des intoxications par envenimation chez les enfants ...

    African Journals Online (AJOL)

    Les signes cliniques étaient dominés par les douleurs (98%) suivies des hémorragies (73,80%) pour les morsures de serpent, la douleur pour les piqures de scorpion (100%) et les oedèmes pour les piqures d'abeilles (100%). Les cas de morsure de serpent ont été traités par le sérum antivenimeux polyvalent. Conclusion: ...

  3. Intoxication par la paraphényléne-diamine

    African Journals Online (AJOL)

    raoul

    9 mars 2011 ... remède contre la douleur par Averbukh [8], ou contre la constipation par Schemesh [9], mais l´utilisation à des fins autolytique reste toujours prédominante. Le tableau clinique de l´intoxication à ... une anurie ayant nécessité le recours à l´hémodialyse. Ce taux de survenue d´IRA anurique est relativement ...

  4. Croissance epitaxiale de GaAs sur substrats de Ge par epitaxie par faisceaux chimiques

    Science.gov (United States)

    Belanger, Simon

    La situation energetique et les enjeux environnementaux auxquels la societe est confrontee entrainent un interet grandissant pour la production d'electricite a partir de l'energie solaire. Parmi les technologies actuellement disponibles, la filiere du photovoltaique a concentrateur solaire (CPV pour concentrator photovoltaics) possede un rendement superieur et mi potentiel interessant a condition que ses couts de production soient competitifs. La methode d'epitaxie par faisceaux chimiques (CBE pour chemical beam epitaxy) possede plusieurs caracteristiques qui la rendent interessante pour la production a grande echelle de cellules photovoltaiques a jonctions multiples a base de semi-conducteurs III-V. Ce type de cellule possede la meilleure efficacite atteinte a ce jour et est utilise sur les satellites et les systemes photovoltaiques a concentrateur solaire (CPV) les plus efficaces. Une des principales forces de la technique CBE se trouve dans son potentiel d'efficacite d'utilisation des materiaux source qui est superieur a celui de la technique d'epitaxie qui est couramment utilisee pour la production a grande echelle de ces cellules. Ce memoire de maitrise presente les travaux effectues dans le but d'evaluer le potentiel de la technique CBE pour realiser la croissance de couches de GaAs sur des substrats de Ge. Cette croissance constitue la premiere etape de fabrication de nombreux modeles de cellules solaires a haute performance decrites plus haut. La realisation de ce projet a necessite le developpement d'un procede de preparation de surface pour les substrats de germanium, la realisation de nombreuses sceances de croissance epitaxiale et la caracterisation des materiaux obtenus par microscopie optique, microscopie a force atomique (AFM), diffraction des rayons-X a haute resolution (HRXRD), microscopie electronique a transmission (TEM), photoluminescence a basse temperature (LTPL) et spectrometrie de masse des ions secondaires (SIMS). Les experiences ont permis

  5. Publicity and public relations

    Science.gov (United States)

    Fosha, Charles E.

    1990-01-01

    This paper addresses approaches to using publicity and public relations to meet the goals of the NASA Space Grant College. Methods universities and colleges can use to publicize space activities are presented.

  6. Avaliação de uma intervenção pedagógica na aprendizagem de crianças com Transtorno de Déficit de Atenção e Hiperatividade - TDAH - no âmbito das políticas públicas do Estado do Pará Evaluación de una intervención pedagógica en la enseñanza de niños com Trastorno de Déficit de Atención y Hiperactividad - TDAH - y en el ámbito de las Políticas Públicas del Estado de Pará Evaluation of a pedagogic intervention in the learning process of children with Attention Deficit and Hyperactivity Disorder and the public policies in Pará State

    OpenAIRE

    Ione Lima Pina; Luciel da Silva Macedo; Manuel Elbio Aquino Sequeira; Iris Lima e Silva; Fabrício Cardoso; Fátima Cunha Pinto; Heron Beresford

    2010-01-01

    As Políticas Públicas Educacionais no Estado do Pará são estabelecidas em consonância com a esfera federal por meio de Diretrizes que objetivam, fundamental-mente, contemplar seus educandos com um ensino equânime e democrático. Os alunos com carências muito especiais encontram guarida em intervenções planejadas e executadas como um valioso meio para preencher positivamente determinadas lacunas. Este artigo objetivou avaliar a eficácia de uma intervenção pedagógica voltada para a aprendizagem ...

  7. State Policy Snapshot: School District Facilities and Public Charter Schools

    Science.gov (United States)

    Simnick, Russ

    2015-01-01

    One of the greatest challenges to the health of the public charter school movement is access to adequate facilities in which the schools operate. Public charter school facilities are rarely funded on par with school district facilities. Over the years, more states have come to realize that they have an obligation to ensure that all public school…

  8. Serum suPAR in patients with FSGS: trash or treasure?

    NARCIS (Netherlands)

    Maas, R.J.H.; Deegens, J.K.J.; Wetzels, J.F.M.

    2013-01-01

    The urokinase-type plasminogen activator receptor (uPAR) has important functions in cell migration. uPAR can be shed from the cell membrane resulting in soluble uPAR (suPAR). Further cleavage gives rise to shorter fragments with largely unknown functions. Recent studies have demonstrated that both

  9. Une terreur par l’image

    Directory of Open Access Journals (Sweden)

    Annie DULONG

    2011-09-01

    Full Text Available Si d’autres événements — Hiroshima, la découverte des camps de concentration, la chute du mur de Berlin — ont, au cours du XXe siècle, marqué suffisamment l’imaginaire pour trouver leur réponse dans des œuvres d’art, le 11 septembre 2001 pose la question de la fictionnalisation autrement : il ne s’agit plus tant de combler les manques de la représentation, liés à l’absence d’images ou au délai dans leur dévoilement, mais bien de composer avec l’omniprésence d’une représentation martelée à la télévision et sur Internet. Que cette représentation soit partielle, tronquée et qu’il lui manque la présence des corps, ces grands absents des photographies et des images tournées par les journalistes, ne change rien au fait que c’est avec le trop-plein que les artistes doivent maintenant négocier.Cet article s’intéresse aux romans qui traitent l’événement de front au lieu de l’aborder sur un mode mineur, et a pour objectif de tracer un portrait de la représentation des médias dans les romans du 11 septembre 2001. Ces romans, outre le fait qu’ils traitent des événements de New York, ont comme point commun un personnage, ou décor : les médias, représentés par la télévision, l’Internet, les photographies de presse, interviennent dans les récits d’une manière significative et témoignent de la force brute des images. À travers une étude de certains des mécanismes à l’œuvre dans The Writing on the Wall (Lynne Sharon Schwartz, Extremely Loud and Incredibly Close (Jonathan Safran Foer, Falling Man (Don DeLillo et A Disorder Peculiar to the Country (Ken Kalfus, il s’agira de proposer des réponses à ces quelques questions : quel rôle les médias jouent-ils, et comment participent-ils au récit ? Quelle pression les images exercent-elles sur les personnages ? Que révèlent les personnages enfants dans leur rapport aux médias ? Quelle critique, finalement, les romans

  10. Par Pond vegetation status Summer 1995 -- June survey descriptive summary

    International Nuclear Information System (INIS)

    Mackey, H.E. Jr.; Riley, R.S.

    1995-06-01

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the shoreline aquatic plant communities in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level, indicated that much of the original plant communities and the intermediate shoreline communities present on the exposed sediments have been lost. The extensive old-field and emergent marsh communities that were present on the exposed shoreline during the drawdown have been flooded and much of the pre-drawdown Par Pond aquatic plant communities have not had sufficient time for re-establishment. The shoreline does, however, have extensive beds of maidencane which extend from the shoreline margin to areas as deep as 2 and perhaps 3 meters. Scattered individual plants of lotus and watershield are common and may indicate likely directions of future wetland development in Par Pond. In addition, within isolated coves, which apparently received ground water seepage and/or stream surface flows during the period of the Par Pond draw down, extensive beds of waterlilies and spike rush are common. Invasion of willow and red maple occurred along the lake shoreline as well. Although not absent from this survey, evidence of the extensive redevelopment of the large cattail and eel grass beds was not observed in this first survey of Par Pond. Future surveys during the growing seasons of 1995, 1996, and 1997 along with the evaluation of satellite date to map the areal extent of the macrophyte beds of Par Pond are planned

  11. Parâmetros físico-químicos incomuns em água de abastecimento público de um município da região nordeste do Estado de São Paulo (Brasil | Unusual physico-chemical parameters in the public water supply of a town in the northeast of the São Paulo State (Brazil

    Directory of Open Access Journals (Sweden)

    Sergio Dovidauskas

    2017-02-01

    Full Text Available Amostras de águas de abastecimento público (n = 4347 de 88 municípios do nordeste do Estado de São Paulo (Brasil foram analisadas em 21 parâmetros físico-químicos: temperatura, condutividade (por condutimetria, cloro residual livre (colorimetria com N,N-dietil-p-fenilenodiamina, pH (potenciometria, cor aparente (espectrofotometria, turbidez (nefelometria, e concentrações de Li+, Na+, NH4+, K+, Ca2+, Mg2+, F-, ClO2-, BrO3-, Cl-, Br-, ClO3-, NO3-, PO43- e SO42- (cromatografia de íons. Os resultados foram submetidos à análise multivariada de dados. A análise de componentes principais das medianas de 12 variáveis (pH, condutividade, Li+, Na+, K+, Ca2+, Mg2+, Cl-, ClO3-, NO3-, PO43-, SO42- dos 88 municípios indicou Ibitinga como local com água de características físico-químicas únicas, caracterizada pelas concentrações relativas mais altas de sulfato, cloreto, lítio e sódio, e aos valores maiores de pH e condutividade. Em adição, Ibitinga foi o único município que apresentou sistematicamente brometo na composição da água. Uma segunda análise de componentes principais envolvendo as amostras de Ibitinga indicou uma amostra com concentrações mais altas de cloreto e sulfato, e quatro amostras nas quais a presença de nitrato foi característica. Análises de agrupamento hierárquico exibiram a formação dos mesmos grupos produzidos nas duas análises de componentes. A validação dos métodos cromatográficos também é apresentada. ================================================ Public water supply samples (n = 4347 from 88 municipalities in the northeast of the State of São Paulo (Brazil were analysed in 21 physico-chemical parameters: temperature, conductivity (by conductimetry, free residual chlorine (colorimetry with N,N-diethyl-p-phenylenediamine, pH (potentiometry, apparent color (spectrophotometry, turbidity (nephelometry, and concentrations of Li+, Na+, NH4+, K+, Ca2+, Mg2+, F-, ClO2-, BrO3-, Cl-, Br-, ClO3

  12. Par Pond vegetation status Summer 1995 -- September survey descriptive summary

    International Nuclear Information System (INIS)

    Mackey, H.E. Jr.; Riley, R.S.

    1995-09-01

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the emergent shoreline aquatic plant communities began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level and continued with this mid-September survey. Communities similar to the pre-drawdown Par Pond aquatic plant communities are becoming re-established; especially, beds of maidencane, lotus, waterlily, and watershield are now extensive and well established. Cattail occurrence continues to increase, but large beds common to Par Pond prior to the drawdown have not formed. Future surveys during the late growing seasons of 1995, and throughout 1996 and 1997, along with the evaluation of satellite data to map the areal extent of the macrophyte beds of Par Pond, are planned

  13. Par Pond vegetation status Summer 1995 -- October survey descriptive summary

    International Nuclear Information System (INIS)

    Mackey, H.E. Jr.; Riley, R.S.

    1995-11-01

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the emergent shoreline aquatic plant communities began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level and continued with this late October survey. Communities similar to the pre-drawdown Par Pond aquatic plant communities are becoming re-established; especially, beds of maiden cane, lotus, waterlily, and watershield are now extensive and well established. Cattail occurrence continues to increase, but large beds common to Par Pond prior to the drawdown have not formed. Future surveys throughout 1996 and 1997, along with the continued evaluation of satellite data to map the areal extent of the macrophyte beds of Par Pond, are planned

  14. Determination of the 20 MeV linear accelerator, new injector for the synchrotron Saturne. Choice of the electrical and dynamical particle parameters; Determination de l'accelerateur lineaire de 20 MeV, nouvel injecteur du synchrotron Saturne. Choix des parametres electriques, dynamique des particules

    Energy Technology Data Exchange (ETDEWEB)

    Prome, M [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1968-12-15

    This report takes place in the general determination of the 20 MeV linear accelerator which will be the new Saturne injector; it deals with particle dynamics. Starting from beam requirements at the output of the linac, cells lengths with variable synchronous phase angle, buncher and de-buncher parameters, beam emittances at the output in several phase spaces are successively determined. (author) [French] Dans le contexte general de la determination de l'accelerateur lineaire de 20 MeV, nouvel injecteur du synchrotron Saturne, ce rapport traite de la partie relative au mecanisme de l'acceleration des particules; a partir des caracteristiques souhaitees pour le faisceau a la sortie de cet accelerateur, on determine successivement les longueurs des cellules, compte tenu du choix d'un angle de phase synchrone variable, les caracteristiques du groupeur et du degroupeur et les emittances du faisceau en sortie dans les differents plans de phase. (auteur)

  15. Leprosy New Case Detection Trends and the Future Effect of Preventive Interventions in Pará State, Brazil: A Modelling Study

    NARCIS (Netherlands)

    H.J. de Matos (Haroldo José); D.J. Blok (David); S.J. de Vlas (Sake); J.H. Richardus (Jan Hendrik)

    2016-01-01

    textabstractBackground: Leprosy remains a public health problem in Brazil. Although the overall number of new cases is declining, there are still areas with a high disease burden, such as Pará State in the north of the country. We aim to predict future trends in new case detection rate (NCDR) and

  16. [Ambroise Paré, his death and his historians].

    Science.gov (United States)

    Dumaître, P

    2001-01-01

    Ambroise Paré died December the 20th., 1590. What happened after his death and what are we knowing about his life? Never forgotten, though a lack of care, we were waiting till the XIXth. century to get recollection upon a subject sustained only by accounts of his travels. After Percy, a surgeon who tried to write Paré's biography through the "Biographie universelle ancienne et moderne, de Michaud (1822)" and some second rank authors, Malgaigne is the first who inside a printing of the "Oeuvres complétes de Paré (1840-41)" has a fine look upon the question, though his work is incomplete and allows many mistakes. Doctors Chéreau and Jal, an historian, analysing civil status records, gave new information enlarged by doctors Le Paulmier, Turner and the U.S. native Janet Doe.

  17. Les techniques de séparation de gaz par membranes Gas Separation Techniques by Membranes

    Directory of Open Access Journals (Sweden)

    Avrillon R.

    2006-11-01

    Full Text Available Deux types de membranes peuvent être utilisés pour la séparation des gaz. Les unes sont poreuses et séparent les gaz sur la base de leur masse moléculaire selon un mécanisme de diffusion de Knudsen dans des micropores. Les facteurs de séparation obtenus sont généralement trop faibles pour présenter un intérêt industriel. Les autres, appelées membranes non poreuses, mettent en oeuvre un mécanisme de dissolution-diffusion des gaz dans une fine couche de polymère dénuée de toute porosité. C'est de ces dernières que nous allons parler. Commencé il y a une vingtaine d'années, le développement de ce type de membranes a conduit aux premières applications industrielles en 1979 avec l'introduction par Monsanto des séparateurs PRISM pour la récupération d'hydrogène à partir de différents gaz de raffinerie et de pétrochimie. Après des débuts modestes par suite de la compétition avec des technologies éprouvées comme la cryogénie, l'adsorption et l'absorption, la perméation gazeuse est en train de conquérir sa place parmi les techniques de séparation de gaz. Elle est aujourd'hui l'une des techniques membranaires présentant le plus fort taux de progression (30 % par an. Après un rappel des principes de base de la perméation gazeuse on abordera successivement les points suivants : - le choix du polymère constituant la couche séparatrice, - l'élaboration des membranes à structure asymétrique présentant une peau dense et fine, - les principales applications industrielles. Cela permettra de mettre en évidence les avantages et les limitations actuelles de la perméation gazeuse et de souligner les différents domaines où les efforts de R et D peuvent amener des progrès significatifs. Principle of Gas permeation - Gas permeation is a technique for fractionating gas mixtures by using nonporous polymer membranes having a selective permeability to gas according to a dissolution-diffusion mechanism. Gas is made to pass

  18. Contribution to the isotopic analysis of nitrogen using optical spectrometry; Contribution a l'analyse isotopique de l'azote par spectrometrie optique

    Energy Technology Data Exchange (ETDEWEB)

    Leicknam, J P [Commissariat a l' Energie Atomique, 91 - Saclay (France). Centre d' Etudes Nucleaires

    1968-07-01

    15 (abondances isotopiques inferieures a 2 pour cent), les methodes proposees jusqu'alors ne donnaient pas rapidement des resultats suffisamment precis. Cette analyse isotopique ne necessite qu'un spectrometre de moyenne resolution; on peut meme, comme nous l'avons fait, utiliser un spectrographe en substituant a la plaque photographique une fente de sortie, suivie d'un photomultiplicateur; cette transformation est tres simple a realiser et les signaux provenant du detecteur peuvent alors etre envoyes sur un enregistreur. Dans ces conditions la duree d'une determination ne demande que de trois a dix minutes, suivant la precision desiree. Les sources de lumiere sont constituees par des lampes a decharge sans electrode, excitees par haute frequence; les conditions de remplissage sont telles que l'on peut preparer des lampes en quelques minutes, les impuretes etant suffisamment eliminees pour ne pas perturber les mesures. Le choix du couple de bandes d'analyse tient compte de la position relative des bandes isotopiques et de la presence eventuelle de traces de ces impuretes: parmi les transitions du systeme C({sup 3}{pi}{sub u}) <-> B({sup 3}{pi}{sub g}), la transition 2 {yields} 0 presente la disposition la plus favorable pour effectuer ce dosage isotopique. La methode est appliquee a des echantillons de diverses provenances (sels ammoniacaux, engrais et plantes): les teneurs isotopiques sont determinees a 3 pour cent pres au voisinage de l'abondance naturelle et a 1 pour cent pres lorsque l'echantillon contient environ 1.5 atomes d'azote 15 pour 100 atomes d'azote 14. La precision est donc largement suffisante pour la plupart des etudes biologiques utilisant, l'atome 15 comme traceur. (auteur)

  19. Keratometric alterations following the 25-gauge transconjunctival sutureless pars plana vitrectomy versus the conventional pars plana vitrectomy.

    Science.gov (United States)

    Citirik, Mehmet; Batman, Cosar; Bicer, Tolga; Zilelioglu, Orhan

    2009-09-01

    To assess the alterations in keratometric astigmatism following the 25-gauge transconjunctival sutureless pars plana vitrectomy versus the conventional pars plana vitrectomy. Sixteen consecutive patients were enrolled into the study. Conventional vitrectomy was applied to eight of the cases and 25-gauge transconjunctival sutureless vitrectomy was performed in eight patients. Keratometry was performed before and after the surgery. In the 25-gauge transconjunctival sutureless pars plana vitrectomy group, statistically significant changes were not observed in the corneal curvature in any post-operative follow-up measurement (p > 0.05); whereas in the conventional pars plana vitrectomy group, statistically significant changes were observed in the first postoperative day (p = 0.01) and first postoperative month (p = 0.03). We noted that these changes returned to baseline in three months (p = 0.26). Both 25-gauge transconjunctival sutureless and conventional pars plana vitrectomy are effective surgical modalities for selected diseases of the posterior segment. Surgical procedures are critical for the visual rehabilitation of the patients. The post-operative corneal astigmatism of the vitrectomised eyes can be accurately determined at least two months post-operatively.

  20. Cyclanthaceae no estado do Pará, Brasil Cyclanthaceae in Pará State, Brazil

    Directory of Open Access Journals (Sweden)

    Eduardo da Silva Leal

    2012-12-01

    Full Text Available Cyclanthaceae apresenta distribuição exclusiva na região neotropical sendo bem diversificada nas terras baixas das florestas pluviais tropicais, ocorrendo do sul do México até a Mata Atlântica do sul do Brasil. Consistem de ervas terrestres, epífitas, hemiepífitas ou lianas. O tratamento taxonômico de Cyclanthaceae no Pará foi baseado em coleções de herbário, trabalhos de campo e consulta a bibliografia referente à família. Foram registradas 11 espécies: Asplundia altiscandens E.S. Leal, A. fanshawei (Maguire Harling, A. glandulosa (Gleason Harling, A. heteranthera Harling, A. latifrons (Drude Harling, A. schizotepala Harling, A. xiphophylla Harling, Cyclanthus bipartitus Poit. ex A. Rich., Evodianthus funifer (Poit. Lindm., Ludovia lancifolia Brongn. e Thoracocarpus bissectus (Vell. Harling. São apresentadas chave de identificação, descrições e ilustrações das espécies, além de comentários sobre distribuição geográfica, hábitat e período de floração e frutificação.Cyclanthaceae is a family with a distribution exclusively in the Neotropics and is well diversified in lowland rainforests, occurring from southern Mexico to the Atlantic Forest of southern Brazil. The family consists of terrestrial herbs, epiphytes, hemiepiphytes and lianas. This taxonomic treatment of the Cyclanthaceae from the state of Pará was based on herbarium specimens, fieldwork, and the literature. Eleven species were recorded: Asplundia altiscandens E.S. Leal, A. fanshawei (Maguire Harling, A. glandulosa (Gleason Harling, A. heteranthera Harling, A. latifrons (Drude Harling, A. schizotepala Harling, A. xiphophylla Harling, Cyclanthus bipartitus Poit. ex A. Rich., Evodianthus funifer (Poit. Lindm., Ludovia lancifolia Brongn. and Thoracocarpus bissectus (Vell. Harling. An identification key, descriptions and illustrations of species are presented. Additional information on the geographic distribution, habitat, and flowering and

  1. Canning by the diffusion caused by a heated die; Gainage par diffusion par filiere chauffante

    Energy Technology Data Exchange (ETDEWEB)

    Gauthron, M [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1959-07-01

    In this process, the uranium fuel is clad with a zirconium can by passing the element through a die. The operation takes place at a temperature varying between 500 and 1000 deg. C. The heating is obtained by passing low voltage electric current through the can. This process differs from the co-extrusion process in that the uranium is not deformed. The uranium is therefore machined to the final dimensions before canning, it can also be hollow. Two types of processes can be adopted for the extrusion: a) Process in which the binding of the can to the uranium is obtained without diffusion (here the can is at high temperature - subsequently cooled - and the uranium is at a low temperature); b) Process in which uranium-zirconium diffusion is initiated. No matter which process is adopted the element is subsequently heat treated in an over at 800 deg. C in order to obtain the final diffusion. The quality of this diffusion is dependent on the initial state of the surfaces and on the degree of vacuum maintained during the operation. (author) [French] Dans ce procede, la gaine zirconium est plaquee sur le combustible uranium par passage dans une filiere. L'operation a lieu a chaud, a une temperature variant entre 500 et 1000 deg. C. Le chauffage est assure par passage d'un courant basse tension dans la gaine. A la difference du procede de cofilage, l'uranium ne subit pas de deformation durant l'operation. Il est donc prealablement usine aux cotes definitives et peut etre creux. Deux processus sont possibles pendant le passage dans la filiere: a) Obtention d'un frettage de la gaine sur l'uranium sans diffusion (avec une gaine a haute temperature et un tube d'uranium a basse temperature, eventuellement refroidi); b) Obtention d'un commencement de diffusion uranium-zirconium. Quelque soit le processus adopte, la cartouche est ensuite traitee dans un four a 800 deg. C pour obtenir la diffusion definitive. La qualite de celle-ci depend essentiellement des etats de surface initiaux

  2. La projection par plasma : une revue

    Science.gov (United States)

    Fauchais, P.; Grimaud, A.; Vardelle, A.; Vardelle, M.

    are presented in the fields of aeronautics and mechanics. La qualité d'un dépôt projete par plasma dépend de nombreux paramètres que l'on commence à mieux appréhender du fait des progrès de la modélisation et de la métrologie tant des écoulements plasmas que des transferts plasma-particules ou que des conditions d'écrasement et de refroidissement des particules lors de leur impact sur le substrat ou les couches déjà déposées. Les techniques de mesure utilisdes et leurs limitations sont d'abord rappelées tant pour les jets de plasma que pour les particules en vol et l'importance des différents phénomènes intervenant dans les transferts plasma-particules est soulignée : gradients de température et de concentration d'espèces chimiques très élevés autour des particules, effets de propagation de la chaleur, notamment pour les particules céramiques, effet d'évaporation, effet de raréfaction sensible dès la pression atmosphérique. Les problèmes de distribution de taille et de vitesse d'injection des particules sont également abordés car ils conditionnent les distributions de trajectoires et donc le traitement des particules dans le jet de plasma. La génération du plasma montre d'une part 1'influence considérable de l'injection du gaz, de sa nature, du dessin de la chambre d'arc et de la tuyère ainsi que du pompage de l'air ambiant sur la longueur des jets de plasma d'arc et d'autre part les problèmes d'injection pour éviter le couplage avec la décharge dans les jets de plasmas R.E Tout ceci est illustré avec des exemples de dépôt d'alumine, de zircone, de cermet carbure et de nickel. L'écrasement des particules est ensuite abordé avec les problèmes de réactions chimiques, de trempe ultra-rapide et donc de structure cristalline des dépôts, d'adhdsion mais aussi de containtes résiduelles et de leur contrôle via les gradients de température dans les dépôts pendant le tir. Enfin quelques applications actuelles sont pr

  3. Determination of oxygen in uranium compounds using sulfur monochloride; Dosage de l'oxygene dans les composes de l'uranium par la methode au monochlorure de soufre

    Energy Technology Data Exchange (ETDEWEB)

    Baudin, G; Besson, J; Blum, P L; Tran-Van, Danh [Commisariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

    1964-07-01

    The authors have described in an other paper (Anal. Chim. Acta, in press) a method for oxygen determination in uranium compounds, in which the sample is attacked by sulfur monochloride. The present paper is concerned with the experimental aspects of the method: apparatus procedure. (authors) [French] Les auteurs ont decrit dans une autre publication (Anal. Chim. Acta) a paraitre, une methode de dosage de l'oxygene dans les composes de l'uranium par attaque par le monochlorure de soufre, La presente note a pour but d'en preciser les techniques experimentale: appareillage, mode operatoire. (auteurs)

  4. Health problems raised by the elimination of radioactive wastes and nuclear accidents; Problemes sanitaires poses par l'elimination des dechets radioactifs et par les accidents nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    Jammet, H; Mechali, D; Dousset, M [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1964-07-01

    The rapid development of nuclear energy demands an urgent solution to the health problems arising from the discharge into the environment of radioactive residues produced by nuclear installations. - To be able to evaluate the risks run by the population and to fix tolerance limits for waste discharge, it is necessary to possess an exact knowledge of the course taken by the radioelements discharged, from their source until they reach man. The incorporation of radioelements in food cycles is the first risk to take into consideration. The factors involved in all stages of this transmission must be foreseen, whether they concern physical or biological media, because of their continuity and their interdependence. Finally, socio-economic and dietetic data must be collected in order that the risks and tolerance levels estimated are based on concrete and experimental rather than theoretical knowledge. The risk of nuclear accidents in the atomic industry, although very improbable, must be taken into consideration because of the seriousness of their consequences. The health problems arise in the field of professional hygiene on the one hand and in that of public hygiene on the other. In the first field the risk is two-fold and involves irradiation and contamination. The public sphere is reduced essentially to the risk of contamination by radioactive substances accidentally released in the surrounding medium. The health studies to be conducted in this field therefore include research not only on irradiation or contamination therapeutics but also on the transfer of radioelements from the accident site to man, mainly through food cycles, in their physical and in their biological components. Studies of this kind form the basis of decisions in the health field which would have to be taken in the case of an accident. (authors) [French] Le developpement rapide de l'energie nucleaire rend urgente la solution des problemes sanitaires poses par le rejet dans le milieu ambiant des

  5. Les Lesions Oculaires Par Jeu de Feu au Cours de Achoura

    Science.gov (United States)

    El Ketani, A.; Amir, F.; Ali, T.B.; Hamdani, M.; Zaghloul, K.

    2006-01-01

    Summary Les enfants célèbrent la fête de Achoura au Maroc par des jeux de feu, ce qui occasionne des blessures oculaires plus au moins graves. Nous rapportons 15 observations de malades traités au Service d'Ophtalmologie Pédiatrique de l'Hôpital 20 Août 1953 de Casablanca. L'âge moyen des patients était de 12 ans et demi, avec des extrêmes de 3 et 25 ans. Les pétards, la première cause des accidents (50%), ont occasionné des contusions oculaires avec parfois un oedème de Berlin (deux cas). L'atteinte oculaire par fusée a occasionné un éclatement de globe et une plaie de paupière. Les bombes de carbone ont été responsables de brûlures de deuxième degré palpébrales et conjonctivo-cornéennes avec de multiples corps étrangers cornéens profonds. Les «étoiles» et la limaille de fer ont provoqué des brûlures cornéennes moins graves avec des corps étrangers superficiels. Les pistolets à bille ont été responsables de contusions oculaires. La réglementation de vente des jeux de feu et la sensibilisation du grand public par les moyens audiovisuels permettraient de prévenir ces blessures oculaires. PMID:21991053

  6. Parasitisme de Dacryodes edulis par le genre Tapinanthus ...

    African Journals Online (AJOL)

    SARAH

    31 août 2013 ... Parasitisme de Dacryodes edulis par le genre. Tapinanthus (Loranthaceae) et répartition de la myrmécofaune associée à Logbessou Plateau. (Douala, Cameroun). Massako F1*, Tchatat M2, Mony R3, Ladoh Yemeda CF1, Dibong SD1,4,5. 1Laboratoire de Biologie et Physiologie des Organismes ...

  7. Parasitisme des champs semenciers de cacaoyers par les ...

    African Journals Online (AJOL)

    SARAH

    30 janv. 2015 ... J. Appl. Biosci. Parasitisme des champs semenciers de cacaoyers par les loranthaceae dans la localité de Nkoemvone (sud Cameroun). 7795 to the various clones, Phragmanthera capitata was the most abundant Loranthaceae; the level of parasitism of cacao trees is more important at the cacao trees of ...

  8. Den eneste ene - hvordan etniske minoritetsunge i Danmark danner par

    DEFF Research Database (Denmark)

    Singla, Rashmi

    Rapporten handler om etniske unges måde at danne par på. Rapporten er baseret på en større empirisk undersøgelse gennemført af forfatteren i 2003 og er desuden inspireret af forfatterens egen ph.d.-afhandling: "Ungdom, etnicitet og psychosocial intervention" (2000, Københavns Universitet). Rappor...

  9. Indications and visual outcome of first hundred pars plana ...

    African Journals Online (AJOL)

    Objective: To review the indications and visual outcome of the first one hundred pars plana vitrectomies performed at the newly established surgical retina unit of Makkah Specialist Eye Hospital, Kano, Kano State, Nigeria. Materials and Methods: Aretrospective chart review was performed. Data recorded from the patient ...

  10. Epuration des effluents industriels par électroflottation Belkacem ...

    African Journals Online (AJOL)

    étudié la séparation de quelques métaux lourds tels que le fer, le nickel, ... the separation of some heavy metals such as iron, nickel, copper, zinc, lead and ... généralement basées sur l'adsorption (par ... Différents essais de concentration en.

  11. Predicting spectral and PAR light attenuation in Greenlandic coastal waters

    DEFF Research Database (Denmark)

    Murray, Ciarán; Markager, Stiig; Stedmon, Colin

    (CDOM), phytoplankton pigments and inorganic particles. These differences are due in part to hydrography and to the sources of meltwater: respectively, fjord-terminating and land-terminating glaciers. We present a model to explain the variation in spectral and PAR irradiance in terms of the variation...

  12. Priapisme induit par la chlorpromazine: A propos de deux cas

    Directory of Open Access Journals (Sweden)

    I. Marrag

    2016-06-01

    Le priapisme veineux est une urgence urologique. Il constitue un des effets secondaires des neuroleptiques parmi les quels la chlorpromazine. Cet effet iatrogène, qui est rare mais grave, doit être connu par les cliniciens afin d’être mieux prévenu pour éviter les séquelles érectiles.

  13. La lecture de Merleau-Ponty par Renaud Barbaras

    Czech Academy of Sciences Publication Activity Database

    Pechar, Jiří

    2015-01-01

    Roč. 11, č. 2 (2015), s. 1-6 ISSN 1336-6556 Institutional support: RVO:67985955 Keywords : Merleau-Ponty * Husserl * phenomenology * linguistics of Ferdinand de Saussure Subject RIV: AA - Philosophy ; Religion http://www.ostium.sk/sk/la-lecture-de-merleau-ponty-par-renaud-barbaras/

  14. Par Pond vegetation status summer 1995 - July survey descriptive summary

    International Nuclear Information System (INIS)

    Mackey, H.E. Jr.; Riley, R.S.

    1995-07-01

    A survey of the emergent shoreline aquatic plant, communities began in June 1995, three months after the refilling of Par Pond to approximately 200 feet (61 meters) above mean sea level, and continued with this July survey. Aquatic plant communities, similar to the pre-drawdown Par Pond communities, are becoming reestablished. Beds of maidencane (Panicum hemitomon), lotus (Nelumbo lutea), water lily (Nymphaea odorata), and watershield (Brasenia schreberi) are now extensive and well established. In addition, within isolated coves, extensive beds of water lilies and spike-rush (Eleocharis sp.) are common. Cattail occurrence has increased since refill, but large beds common to Par Pond prior to the drawdown have not formed. Invasion of willow (Salix sp.) and red maple (Acer rubrum) occurred along the lake shoreline during drawdown. The red maples along the present shoreline are beginning to show evidence of stress and mortality from flooding over the past four months. Some of the willows appear to be stressed as well. The loblolly pines (Pinus taeda), which were flooded in all but the shallow shoreline areas, are now dead. Future surveys are planned for the growing seasons of 1995, 1996, and 1997, along with the evaluation of satellite data for mapping the areal extent of the macrophyte beds of Par Pond

  15. fortification des farines tropicales par l'introduction de proteines ...

    African Journals Online (AJOL)

    2Université d'Abomey Calavy, Faculté des Sciences et Techniques, Bénin ... valeur recommandée par le Codex Alimentarius pour ce type de complément alimentaire destiné aux enfants. ..... neurotransmission, coagulation sanguine et.

  16. [Santa Casa de Misericórdia and hygienist policies in Belém do Pará in the late nineteenth century].

    Science.gov (United States)

    Miranda, Cybelle Salvador; Beltrão, Jane Felipe; Henrique, Márcio Couto; Bessa, Brena Tavares

    2015-01-01

    The article analyzes the relationship between hygienist policies in effect in Belém in the late nineteenth century and the expansion of activities of the Santa Casa de Misericórdia do Pará. Considered one of the first hospital institutions in the former Grão-Pará Province, in addition to its own hospital, the Brotherhood administered several other health facilities in the capital, and the study of its physical displacement made it possible to "map" three health centers in Belém: Pioneer, Expansion and the Santa Casa, which reinforce the growth vectors of the city. The expansion of its activities is configured as the expansion of the Santa Casa de Misericórdia to serve the underprivileged and sick, preceding the establishment of a public health system in Pará.

  17. Caesium absorption by barley - influence of its retention by the soil - competitive action of potassium; Absorption du cesium par l'orge - influence de sa retention dans le sol - action competitive du potassium

    Energy Technology Data Exchange (ETDEWEB)

    Ferron-Trosseau, F. [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1964-06-01

    . Par ailleurs, l'ion K{sup +} n'a concurrence l'absorption de Cs{sup +} par l'orge en milieux de culture sur solution nutritive et sur sol, que jusqu'a des doses relativement faibles de potassium, de l'ordre de l'optimum nutritif. Ceci montre que l'addition de potassium a un milieu deja riche en cet element ne reduit plus l'absorption de cesium par l'orge. Le choix de conditions experimentales proches des conditions naturelles (milieux nutritifs a dominante de calcium) et l'examen de la distribution du cesium radioactif entre sol, solution du sol et plante en presence de tres petites doses de cesium stable, conferent a ces resultats un interet 'hygiene atomique': on doit s'attendre a un risque de contamination certain pour les vegetaux cultives sur milieux synthetiques et pour les vegetaux croissant sur des sols inondes tels que le riz et le cresson. Mais le cesium radioactif incorpore sans entraineur a un sol de capacite d'echange moyenne (de l'ordre de 150 milliequivalents par kg) presente relativement peu de danger, du fait de la dependance etroite entre le prelevement de Cs radioactif du sol par les plantes et sa retention dans le sol. Nos experiences nous ont permis en outre d'examiner la valeur des moyens de decontamination partielle d'un sol proposes par certains atomistes: de meme que la dilution isotopique se revele totalement inefficace sous cet angle, l'apport de sels de potasse en quantite depassant l'optimum nutritif se revele incapable de reduire l'absorption de cesium radioactif par la plante.

  18. Caesium absorption by barley - influence of its retention by the soil - competitive action of potassium; Absorption du cesium par l'orge - influence de sa retention dans le sol - action competitive du potassium

    Energy Technology Data Exchange (ETDEWEB)

    Ferron-Trosseau, F [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1964-06-01

    'absorption de Cs{sup +} par l'orge en milieux de culture sur solution nutritive et sur sol, que jusqu'a des doses relativement faibles de potassium, de l'ordre de l'optimum nutritif. Ceci montre que l'addition de potassium a un milieu deja riche en cet element ne reduit plus l'absorption de cesium par l'orge. Le choix de conditions experimentales proches des conditions naturelles (milieux nutritifs a dominante de calcium) et l'examen de la distribution du cesium radioactif entre sol, solution du sol et plante en presence de tres petites doses de cesium stable, conferent a ces resultats un interet 'hygiene atomique': on doit s'attendre a un risque de contamination certain pour les vegetaux cultives sur milieux synthetiques et pour les vegetaux croissant sur des sols inondes tels que le riz et le cresson. Mais le cesium radioactif incorpore sans entraineur a un sol de capacite d'echange moyenne (de l'ordre de 150 milliequivalents par kg) presente relativement peu de danger, du fait de la dependance etroite entre le prelevement de Cs radioactif du sol par les plantes et sa retention dans le sol. Nos experiences nous ont permis en outre d'examiner la valeur des moyens de decontamination partielle d'un sol proposes par certains atomistes: de meme que la dilution isotopique se revele totalement inefficace sous cet angle, l'apport de sels de potasse en quantite depassant l'optimum nutritif se revele incapable de reduire l'absorption de cesium radioactif par la plante.

  19. Espace public et figures du lien social

    OpenAIRE

    Lambert, Cédric; Pellegrino, Pierre; Jacot-Guillarmod, Frédéric Roland

    1990-01-01

    Par une mise en relation des concepts sociologiques d'espace public, communautaire et privé, on se propose ici d'analyser les changements qui affectent le sens de l'espace public contemporain dont l'unité se cherche à des échelles et dans des temporalités multiples; de nouvelles formes d'articulation entre intégration et distanciation réorganisent le partage et la communication des valeurs.

  20. Investigating teachers’ exploration of a professional development website: An innovative approach to understanding the factors that motivate teachers to use Internet-based resources / Investigation de l’exploration par les enseignants d’un site Web

    Directory of Open Access Journals (Sweden)

    Pamela Beach

    2014-08-01

    Full Text Available This qualitative study examined an innovative methodology, combining screen capture technology and a retrospective think aloud, for exploring the use of Internet-based resources by elementary teachers. Pre-service and in-service teachers explored The Balanced Literacy Diet, a free, interactive, and evidenced-informed professional development website. As participants navigated through this complex site, each visual step was captured using Camtasia Studio, a screen recording computer software program developed by TechSmith. Immediately following their 10-minute exploration, participants revisited their online choices virtually and verbalized their thoughts while viewing their screen recording. Qualitative analysis confirmed the usefulness of the methodology and provided insights about the factors that motivate teachers to use professional development websites. Results of the analysis can contribute to the ongoing development of high quality online learning environments. Cette étude qualitative s’est penchée sur une méthodologie innovatrice combinant les technologies de saisie d’écran et la pensée rétrospective à voix haute pour l’exploration de l’utilisation des ressources dans Internet par les enseignants de l’élémentaire. Des enseignants en formation initiale et des enseignants sur place ont exploré The Balanced Literacy Diet, un site Web de perfectionnement professionnel gratuit, interactif et s’appuyant sur des données probantes. Tandis que les participants naviguaient dans ce site complexe, chaque étape visuelle était captée à l’aide de Camtasia Studio, un logiciel d’enregistrement de l’écran développé par TechSmith. Immédiatement après leur exploration de 10 minutes, les participants ont revisité virtuellement leurs choix en ligne et ont verbalisé leurs réflexions en regardant l’enregistrement de l’écran. L’analyse qualitative a confirmé l’utilité de la méthodologie et a fourni des

  1. 1/38 GROUNDS FOR DISPENSING WITH PUBLIC TENDER ...

    African Journals Online (AJOL)

    Administrator

    2010-01-25

    Jan 25, 2010 ... value of public procurement (excluding the procurement of public corporations) ... money in government contracting, the fair treatment of contractors and the use ... 6 For detailed discussion, see Bolton Government Procurement ch 3, par 4. ... 8 On 'cost-effectiveness', see Collins English Dictionary 380 and ...

  2. The role of pars flaccida in human middle ear sound transmission.

    Science.gov (United States)

    Aritomo, H; Goode, R L; Gonzalez, J

    1988-04-01

    The role of the pars flaccida in middle ear sound transmission was studied with the use of twelve otoscopically normal, fresh, human temporal bones. Peak-to-peak umbo displacement in response to a constant sound pressure level at the tympanic membrane was measured with a noncontacting video measuring system capable of repeatable measurements down to 0.2 micron. Measurements were made before and after pars flaccida modifications at 18 frequencies between 100 and 4000 Hz. Four pars flaccida modifications were studied: (1) acoustic insulation of the pars flaccida to the ear canal with a silicone rubber baffle, (2) stiffening the pars flaccida with cyanoacrylate cement, (3) decreasing the tension of the pars flaccida with a nonperforating incision, and (4) perforation of the pars flaccida. All of the modifications (except the perforation) had a minimal effect on umbo displacement; this seems to imply that the pars flaccida has a minor acoustic role in human beings.

  3. Apoplejía pituitaria con parálisis del III par craneal: Reporte de caso

    Directory of Open Access Journals (Sweden)

    Miguel Pinto Valdivia

    2011-10-01

    Full Text Available Se describe el caso de un varón de 65 años de edad, sin antecedentes patológicos de importancia, que acudió a emergencia del Hospital Nacional Cayetano Heredia por presentar cefalea intensa y ptosis palpebral izquierda. El examen físico mostró parálisis aislada del III par craneal izquierdo. Los análisis de laboratorio mostraron hiponatremia e hipopituitarismo y la resonancia magnética nuclear un adenoma pituitario con áreas de hemorragia e invasión de los senos cavernosos. El tratamiento incluyó glucocorticoides y descompresión quirúrgica transesfenoidal. La anatomía patológica confirmó el diagnóstico de infarto hemorrágico de un adenoma pituitario. El paciente fue dado de alta con terapia sustitutiva de levotiroxina y prednisona. La ptosis palpebral izquierda se recuperó en forma parcial. La apoplejía pituitaria es un síndrome clínico producido por un proceso expansivo dentro de la silla turca, secundario a hemorragia o infarto de un adenoma pituitario, que se caracteriza por cefalea, déficit visual, oftalmoplejía y alteración del nivel de conciencia. Este proceso expansivo puede comprimir los pares craneales en los senos cavernosos, produciendo diferentes grados de parálisis de los músculos oculomotores. La parálisis aislada del III par craneal es rara.(Rev Med Hered 2011;22:186-189.

  4. Épidémiologie de l'intoxication par envenimation chez les enfants ...

    African Journals Online (AJOL)

    Introduction: L'intoxication par envenimation est l'ensemble des manifestations locales et générales induites par la pénétration dans l'organisme d'une substance toxique produite par un animal venimeux. Le but de notre travail était d'étudier les signes cliniques des intoxications par envenimation chez les enfants de 0 à 15 ...

  5. Perspectives de développement de la production industrielle d'hydrogène par électrolyse alcaline avancée Development Outlook for Industrial Hydrogen Production by Advanced Alkaline Electrolysis

    Directory of Open Access Journals (Sweden)

    Derive C.

    2006-11-01

    Full Text Available Dans les conditions du développement du programme nucléaire français qui permettent une production d'électricité à un coût intéressant en heures creuses, la production d'hydrogène par électrolyse de l'eau peut être envisagée à moyen terme en compétition avec les autres procédés de fabrication d'hydrogène tels que le reformage de gaz naturel. Dans le cadre de leur coopération, Électricité de France (EDF et le Gaz de France (GDF conduisent, depuis 1976, un programme de recherches et développement sur la production d'hydrogène par électrolyse alcaline de l'eau ayant pour but, par comparaison avec des installations existantes, de réduire le coût d'investissement et de conserver un rendement identique. Les études préalables ont montré que ces objectifs pouvaient être atteints par une électrolyse avancée avec élévation de la densité de courant et de la température. Ces contraintes techniques ont conduit EDF et le GDF à lancer des études sur la tenue chimique et la résistance mécanique des matériaux, sur une sélection de composants de cellules adaptés et sur l'amélioration de la conception d'ensemble des installations. Les deux groupements industriels français - pilotés par Alsthom-Atlantique et Creusot-Loire - associés à ces travaux depuis 1979, ont fixé les conditions de fonctionnement suivantes : - électrolyte à base de potasse (40 % en masse; - température de 120 et 160°C; - pression de 30 et 70 bar. Dans un premier temps, les constructeurs ont réalisé une étude technico-économique sur la production massive d'hydrogène à partir d'usines de puissance d'environ 300 MWe, fourni les plans de détail d'une installation pilote de 2 MWe et entrepris la qualification de leurs choix technologiques sur des boucles-prototypes de 25-30 kWe. Afin de valider plus complètement les choix retenus et d'approfondir les problèmes d'extrapolation à des électrolyseurs de grande taille, les essais sur boucles

  6. Soluble urokinase plasminogen activator receptor (suPAR) in acute care

    DEFF Research Database (Denmark)

    Rasmussen, Line Jee Hartmann; Ladelund, Steen; Haupt, Thomas Huneck

    2016-01-01

    for age, sex, Charlson score and C reactive protein. Area under the curve for receiver operating characteristics curve analysis of suPAR for 30-day mortality was 0.84 (95% CI 0.81 to 0.86). Furthermore, in the entire cohort, women had slightly higher suPAR compared with men, and suPAR was associated...

  7. Movement and equipositioning of plasmids by ParA filament disassembly

    DEFF Research Database (Denmark)

    Ringgaard, Simon; van Zon, Jeroen; Howard, Martin

    2009-01-01

    , plasmids consistently migrate behind disassembling ParA cytoskeletal structures, suggesting that ParA filaments pull plasmids by depolymerization. The perpetual cycles of ParA assembly and disassembly result in continuous relocation of plasmids, which, on time averaging, results in equidistribution...

  8. Protease-Activated Receptor 4 (PAR4): A Promising Target for Antiplatelet Therapy.

    Science.gov (United States)

    Rwibasira Rudinga, Gamariel; Khan, Ghulam Jilany; Kong, Yi

    2018-02-14

    Cardiovascular diseases (CVDs) are currently among the leading causes of death worldwide. Platelet aggregation is a key cellular component of arterial thrombi and major cause of CVDs. Protease-activated receptors (PARs), including PAR1, PAR2, PAR3 and PAR4, fall within a subfamily of seven-transmembrane G-protein-coupled receptors (GPCR). Human platelets express PAR1 and PAR4, which contribute to the signaling transduction processes. In association with CVDs, PAR4 not only contributes to platelet activation but also is a modulator of cellular responses that serve as hallmarks of inflammation. Although several antiplatelet drugs are available on the market, they have many side effects that limit their use. Emerging evidence shows that PAR4 targeting is a safer strategy for preventing thrombosis and consequently may improve the overall cardiac safety profile. Our present review summarizes the PAR4 structural characteristics, activation mechanism, role in the pathophysiology of diseases and understanding the association of PAR4 targeting for improved cardiac protection. Conclusively, this review highlights the importance of PAR4 antagonists and its potential utility in different CVDs.

  9. Protease-Activated Receptor 4 (PAR4: A Promising Target for Antiplatelet Therapy

    Directory of Open Access Journals (Sweden)

    Gamariel Rwibasira Rudinga

    2018-02-01

    Full Text Available Cardiovascular diseases (CVDs are currently among the leading causes of death worldwide. Platelet aggregation is a key cellular component of arterial thrombi and major cause of CVDs. Protease-activated receptors (PARs, including PAR1, PAR2, PAR3 and PAR4, fall within a subfamily of seven-transmembrane G-protein-coupled receptors (GPCR. Human platelets express PAR1 and PAR4, which contribute to the signaling transduction processes. In association with CVDs, PAR4 not only contributes to platelet activation but also is a modulator of cellular responses that serve as hallmarks of inflammation. Although several antiplatelet drugs are available on the market, they have many side effects that limit their use. Emerging evidence shows that PAR4 targeting is a safer strategy for preventing thrombosis and consequently may improve the overall cardiac safety profile. Our present review summarizes the PAR4 structural characteristics, activation mechanism, role in the pathophysiology of diseases and understanding the association of PAR4 targeting for improved cardiac protection. Conclusively, this review highlights the importance of PAR4 antagonists and its potential utility in different CVDs.

  10. Par3L enhances colorectal cancer cell survival by inhibiting Lkb1/AMPK signaling pathway

    International Nuclear Information System (INIS)

    Li, Taiyuan; Liu, Dongning; Lei, Xiong; Jiang, Qunguang

    2017-01-01

    Partitioning defective 3-like protein (Par3L) is a recently identified cell polarity protein that plays an important role in mammary stem cell maintenance. Previously, we showed that high expression of Par3L is associated with poor survival in malignant colorectal cancer (CRC), but the underlying mechanism remained unknown. To this end, we established a Par3L knockout colorectal cancer cell line using the CRISPR/Cas system. Interestingly, reduced proliferation, enhanced cell death and caspase-3 activation were observed in Par3L knockout (KO) cells as compared with wildtype (WT) cells. Consistent with previous studies, we showed that Par3L interacts with a tumor suppressor protein liver kinase B1 (Lkb1). Moreover, Par3L depletion resulted in abnormal activation of Lkb1/AMPK signaling cascade. Knockdown of Lkb1 in these cells could significantly reduce AMPK activity and partially rescue cell death caused by Par3L knockdown. Furthermore, we showed that Par3L KO cells were more sensitive to chemotherapies and irradiation. Together, these results suggest that Par3L is essential for colorectal cancer cell survival by inhibiting Lkb1/AMPK signaling pathway, and is a putative therapeutic target for CRC. - Highlights: • Par3L knockout using the CRISPR/Cas system induces apoptosis in colorectal cancer cells. • Par3L interacts with Lkb1 and regulates the activity of AMPK signaling cascade. • Par3L knockout cells are more sensitive to treatment of different chemotherapy drugs and irradiation.

  11. Brésil : La contamination par le mercure en Amazonie | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    11 janv. 2011 ... En tentant de déceler la source de la contamination de l'Amazone par le ... par Jean-Rémy Davy Guimaraes de l'Université fédérale de Rio de Janeiro ... ces mattes est circonscrite par la conservation et la restauration en rive.

  12. Trends in Extreme Climate Indices for Pará State, Brazil

    Directory of Open Access Journals (Sweden)

    Carlos Antonio Costa dos Santos

    Full Text Available Abstract The present study aimed to analyze trends in air temperature and rainfall for 13 locations in the state of Pará using nonparametric tests. Daily data of maximum and minimum air temperatures and precipitation covering the period 1970-2006, collected by the Instituto Nacional de Meteorologia (INMET have been used. From the results obtained it was observed that the number of warm days and nights per year has increased, thereby providing a significant reduction in the number of cool days and nights in the state. Due to the high space-time variability of precipitation, few localities showed statistically significant trends for indices of extremes dependent on this variable. The days and nights in Belém have been hotter in the last two decades. Therefore, these results are important for future planning of public health and energy for the state of Para, which must adapt to future warming scenarios sectors.

  13. La syphilis congenitale revelee par une fracture spontanee

    Directory of Open Access Journals (Sweden)

    Mounia Lakhdar Idrissi

    2011-11-01

    Full Text Available Alors qu�elle est actuellement oubliee dans les pays developpes, la syphilis congenitale se voit encore chez nous faute du depistage antenatal. Ses formes cliniques sont polymorphes et orientent a tord vers d�autres pathologies surtout en periode neonatale. Le diagnostic n�est donc pas toujours facile. La revelation d�une syphilis congenitale par une fracture spontanee est exceptionnellement decrite. Nous rapportons dans ce travail le cas d�un nourrisson de 2 mois ramene en consultation pour limitation douloureuse des mouvements du bras droit. Le diagnostic est evoque sur les donnees radiologiques et confirme par la serologie syphilitique. Le traitement a repose essentiellement sur l�administration de la penicilline G avec une bonne evolution clinique.

  14. Results of Preliminary Tests of PAR Bunch Cleaning

    CERN Document Server

    Yao, Chihyuan; Grelick, Arthur; Lumpkin, Alex H; Sereno, Nicholas S

    2005-01-01

    A particle accumulator ring (PAR) is used at the Advanced Photon Source (APS) to collect multiple linac bunches and compress them into a 0.3-ns (rms) single bunch for booster injection. A 9.77-MHz fundamental rf system and a 117.3-MHz harmonic rf system are employed for initial beam capture and bunch length compression. Satellite bunches with very low charge form due to rf phase drifts or beam loading change. These satellites, when injected into the booster and then into the storage ring (SR), cause bunch impurity at three buckets from the target bucket. Storage ring and booster bunch cleaning was tried but proved to be difficult due to the top-up mode of operation in the storage ring and tune drift in the booster synchrotron. Recently we implemented a PAR bunch-cleaning system with tune-modulated harmonic rf knockout. Preliminary tests gave a measured SR bunch purity of better than 10

  15. Avis 6 sur la formation à et par la recherche

    OpenAIRE

    Centre de Coopération Internationale en Recherche Agronomique pour le Développement

    2015-01-01

    La formation à et par la recherche s’appuie sur la démarche scientifique, les savoirs, les connaissances à transmettre, tout autant que l’acquisition de compétences en gestion de projet, de capacités au travail en équipe, d’une ouverture d’esprit qui favorisera la créativité. Elle doit permettre de prendre conscience de la responsabilité endossée par la communauté scientifique vis-à-vis de la société et de l’environnement, mais aussi préparer l’avenir professionnel de celle ou de celui qu...

  16. Evaluation of the Stability After Orthodontic Treatment Using PAR Index

    Directory of Open Access Journals (Sweden)

    Chaitra Ramanathan

    2006-01-01

    Full Text Available The aim of the present study is to establish the results using the scores obtained from the methodology that was applied for assessing the stability after 2 years post orthodontic treatment and stability in a sample of 69 individuals. After applying PAR index to the collected group of patients, a series of scores were obtained, which were then needed to be evaluated further to establish the results. The scores were evaluated using the nomogram. A comparison was done between the post treatment and the 2 years post treatment PAR weighting scores to determine if the results were stable after orthodontic treatment. The majority of the orthodontic patients were treated to a good standard and that the results appeared to be stable.

  17. Avaliação de uma intervenção pedagógica na aprendizagem de crianças com Transtorno de Déficit de Atenção e Hiperatividade - TDAH - no âmbito das políticas públicas do Estado do Pará Evaluación de una intervención pedagógica en la enseñanza de niños com Trastorno de Déficit de Atención y Hiperactividad - TDAH - y en el ámbito de las Políticas Públicas del Estado de Pará Evaluation of a pedagogic intervention in the learning process of children with Attention Deficit and Hyperactivity Disorder and the public policies in Pará State

    Directory of Open Access Journals (Sweden)

    Ione Lima Pina

    2010-03-01

    Full Text Available As Políticas Públicas Educacionais no Estado do Pará são estabelecidas em consonância com a esfera federal por meio de Diretrizes que objetivam, fundamental-mente, contemplar seus educandos com um ensino equânime e democrático. Os alunos com carências muito especiais encontram guarida em intervenções planejadas e executadas como um valioso meio para preencher positivamente determinadas lacunas. Este artigo objetivou avaliar a eficácia de uma intervenção pedagógica voltada para a aprendizagem de crianças, entre 7 e 10 anos, com diagnóstico interdisciplinar de Transtorno de Déficit de Atenção e Hiperatividade (TDAH. Aplicou-se o Teste de Processamento Mental, o Teste de Desenvolvimento Escolar e uma Intervenção Pedagógica a partir da combinação de um programa de atividades ludomotoras, composta de jogos educacionais, com um programa de estimulação cortical. Os resultados sugeridos forneceram respostas não conservadoras e positivas, relacionadas à aquisição da linguagem lectoescrita. Ademais, a intervenção, com base na ludoergomotricidade, mostrou efeito positivo e seu valor comprovado por permitir uma melhora dessas crianças em relação à dificuldade por elas expressada.Las Políticas Públicas de Educación en el Estado de Pará, Brasil, son establecidas en consonancia con la esfera Federal por medio de Directrices que objetivan fundamentalmente, contemplar sus educandos con una enseñanza ecuánime y democrática. Los alumnos con necesidades muy especiales encuentran refugio en intervenciones planeadas y ejecutadas como un valioso medio para llenar positivamente determinadas lagunas. Este artículo tuvo el objetivo de evaluar la eficacia de una intervención pedagógica destinada a la enseñanza de niños entre 7 y 10 años, diagnosticados con Trastorno de Déficit de Atención y Hiperactividad.(TDAH. Fue aplicado el Teste de Procesamiento Mental, el Teste de Desarrollo Escolar, y una Intervención Pedag

  18. Nouvelles méthodes d'identification des fractures par diagraphie acoustique en full wave form New Methods of Identifying Fractures by Full Wave Form Acoustic Logging

    Directory of Open Access Journals (Sweden)

    Denis A.

    2006-11-01

    Full Text Available Les outils acoustiques de dernière génération permettent maintenant d'enregistrer l'ensemble des ondes générées par une source acoustique à l'intérieur d'une géométrie cylindrique telle qu'un puits de sondage. Le train d'onde qu'il est alors possible d'analyser se compose successivement de trois composantes majeures (l'onde de compression, de cisaillement et de Stoneley dont nous avons une représentation pour chaque position de la sonde à l'intérieur du puits. Nous présentons, dans ce texte, trois méthodes originales et rapides (calculs possibles sur le site même pour identifier, à partir du traitement de l'onde de Stoneley, les fractures ouvertes recoupées par un forage. Nous donnons, dans un premier temps, nos motivations pour le choix unique du traitement de l'onde de Stoneley pour, dans un deuxième temps, exposer les trois méthodes développées et montrer pour chacune d'entre elles une application pratique. Interest in recognizing and identifying fractures in a coherent formation for the petroleum, geothermal and storage (oil and gas, wastes sectors has led to the development of indirect prospection methods inside boreholes such as acoustic logging. The latest acoustic tools are capable of recording all waves generated by an acoustic logging tool inside a cyclindrical geometry such as a borehole. The wavetrain that can then be analyzed is successively made up of three major components (the P compression wave, the S shear wave and the Stoneley wave for which we have a representation for each position of the logging tool in the borehole. An example of a recording is shown in Fig. 1. Because of its specific features (high amplitudes, low frequency, high signal-to-noise ratio, the Stoneley wave is recognized to be a good indicator of open fractures. Therefore, we use simple digital processing to quantify the influence of fracturing on the propagation of the Stoneley wave. Three methods stemming from the digital processing of

  19. La parálisis cerebral en el contexto escolar /

    OpenAIRE

    González Vara, Azucena

    2012-01-01

    Se analiza el concepto de parálisis cerebral, los diferentes tipos y sus características. También las adaptaciones que se deben realizar a nivel de centro, de aula, y a nivel individual para estos alumnos, conocer los diferentes sistemas alternativos y aumentativos de comunicación y aplicar las ayudas técnicas que precisa este alumnado

  20. Tuberculose lymphonodale cervicale chez les enfants vaccines par ...

    African Journals Online (AJOL)

    La tuberculose ganglionnaire cervicale est une localisation extrapulmonaire relativement fréquente chez l'enfant. Elle pose essentiellement des difficultés de prévention. L'objectif de ce travail est d'étudier les particularités diagnostiques et thérapeutiques chez des enfants vaccinés par le BCG. Matériel et méthodes: Nôtre ...

  1. Traitement De La Peripneumonie Contagieuse Bovine Par L ...

    African Journals Online (AJOL)

    Traitement De La Peripneumonie Contagieuse Bovine Par L'oxyteTracycline Longe Action Et Transmission Experimentale de la Maladie A Partir de Bovins Traites. ... Tous les 14 animaux ont séroconverti et l'analyse post-mortem a montré la présence des lésions chroniques dont des séquestres pulmonaires chez 4 d'entre ...

  2. Adoption d'innovations agricoles par le truchement de services ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    L'agriculture est le fer de lance de nombreuses économies en développement, mais la capacité des petits agriculteurs privés de ressources à adopter des innovations agricoles est freinée par le manque d'accès à des services financiers adéquats. Des experts internationaux estiment qu'il existe un manque à gagner ...

  3. Candido: Uma Leitura Paródica de Candide

    Directory of Open Access Journals (Sweden)

    Maria Gloria Cusumano Mazzi

    2010-12-01

    Full Text Available O presente artigo estuda a leitura paródica que Leonardo Sciascia (1921-1989 faz de Voltaire (1694-1778 mediante o cotejo das obras: o hipertexto Candido ovvero Un sogno fatto in Sicilia (1977 e o hipotexto Candide ou l’optimisme (1759. Apresenta ainda outra possibilidade de leitura, ou seja, Candido como metáfora da própria intertextualidade.

  4. Solution volumes finis polynomiale par morceaux pour les ...

    African Journals Online (AJOL)

    Nous présentons dans ce papier un concept de solution volumes finis continue pour des problèmes de diffusion-convection avec des données régulières. Nous comparons dans certains cas particuliers la solution proposée avec la solution volumes finis classiques (qui est une fonction constante par morceaux) et la ...

  5. Preliminary Analysis For Wolsong Par Effects Using ISACC Calculations

    International Nuclear Information System (INIS)

    Song, Yong Mann; Kim, Dong Ha

    2012-01-01

    In the paper, hydrogen control effects using PARs only are analyzed for severe SBO station blackout (SBO) sequences beyond the design basis accidents in WS-1 which are of CANDU6 type reactor. As a computational tool, the latest version of ISAAC4.3 (Integrated Severe Accident Analysis Code for CANDU), which is a fully integrated and lumped severe accident computer code, is used to simulate hydrogen generation and transport inside the reactor building (R/B) before its failure. For the performance of hydrogen removal, the depletion rate equation of K-PAR developed in Korea is applied. In a CANDU reactor, three areas are identified as sources of hydrogen under severe accidents: fuel-coolant interactions in intact channels, suspended fuel or debris interactions in-calandria tank and debris interactions in-calandria vault. The first two origins provide source for the late ('late' terminology is used because it takes more than one day before calandria tank failure) potential hydrogen combustion before calandria tank failure and all the three origins would provide source for the very late potential hydrogen combustion occurring at or after calaria tank failure. If the hydrogen mitigation system fails, the AICC (adiabatic isochoric complete combustion) burning of highly flammable hydrogen may cause Wolsong R/B failure. So hydrogen induced failure possibility is evaluated, using preliminary ISAAC calculations, under several SBO conditions with and without PAR for both late and very late accident periods

  6. Protease activated receptors (PARS) mediation in gyroxin biological activity

    International Nuclear Information System (INIS)

    Silva, Jose Alberto Alves da

    2009-01-01

    Gyroxin is a serine protease enzyme from the South American rattlesnake (Crotalus durissus terrificus) venom; it is only partially characterized and has multiple activities. Gyroxin induces blood coagulation, blood pressure decrease and a neurotoxic behavior named barrel rotation. The mechanisms involved in this neurotoxic activity are not known. Whereas gyroxin is a member of enzymes with high potential to become a new drug with clinical applications such as thrombin, batroxobin, ancrod, tripsyn and kalicrein, it is important to find out how gyroxin works. The analysis on agarose gel electrophoresis and circular dichroism confirmed the molecules' integrity and purity. The gyroxin intravenous administration in mice proved its neurotoxicity (barrel rotation). In vivo studies employing intravital microscopy proved that gyroxin induces vasodilation with the participation of protease activated receptors (PARs), nitric oxide and Na+K+ATPase. The leukocytes' adherence and rolling counting indicated that gyroxin has no pro inflammatory activity. Gyroxin induced platelet aggregation, which was blocked by inhibitors of PAR1 and PAR4 receptors (SCH 79797 and tcY-NH 2 , respectively). Finally, it was proved that the gyroxin temporarily alter the permeability of the blood brain barrier (BBB). Our study has shown that both the protease-activated receptors and nitric oxide are mediators involved in the biological activities of gyroxin. (author)

  7. A Bipolar Spindle of Antiparallel ParM Filaments Drives Bacterial Plasmid Segregation

    DEFF Research Database (Denmark)

    Gayathri, P; Fujii, T; Møller-Jensen, Jakob

    2012-01-01

    the spindle between ParRC complexes on sister plasmids. Using a combination of structural work and total internal reflection fluorescence microscopy, we show that ParRC bound and could accelerate growth at only one end of polar ParM filaments, mechanistically resembling eukaryotic formins. The architecture...... of ParM filaments enabled two ParRC-bound filaments to associate in an antiparallel orientation, forming a bipolar spindle. The spindle elongated as a bundle of at least two antiparallel filaments, thereby pushing two plasmid clusters toward the poles....

  8. First (18)F-labeled ligand for PET imaging of uPAR

    DEFF Research Database (Denmark)

    Persson, Morten; Liu, Hongguang; Madsen, Jacob

    2013-01-01

    Urokinase-type plasminogen activator receptor (uPAR) is overexpressed in human prostate cancer and uPAR has been found to be associated with metastatic disease and poor prognosis. AE105 is a small linear peptide with high binding affinity to uPAR. We synthesized an N-terminal NOTA......-conjugated version (NOTA-AE105) for development of the first (18)F-labeled uPAR positron-emission-tomography PET ligand using the Al(18)F radiolabeling method. In this study, the potential of (18)F-AlF-NOTA-AE105 to specifically target uPAR-positive prostate tumors was investigated....

  9. Intact and cleaved uPAR forms: diagnostic and prognostic value in cancer

    DEFF Research Database (Denmark)

    Rasch, M.G.; Lund, I.K.; Hoyer-Hansen, G.

    2008-01-01

    identified in tissue and body fluids. It is well-established, that the total amount of all uPAR forms is a strong prognostic marker in different types of cancer. Using immunoassays, measuring the individual uPAR forms, has revealed that the cleaved uPAR forms are even stronger prognostic markers and have...... diagnostic utility. This review will focus on the mechanism of uPAR cleavage and the functional consequences, as well as the clinical applicability of cleaved uPAR forms Udgivelsesdato: 2008...

  10. Dynamic Filament Formation by a Divergent Bacterial Actin-Like ParM Protein.

    Directory of Open Access Journals (Sweden)

    Anthony J Brzoska

    Full Text Available Actin-like proteins (Alps are a diverse family of proteins whose genes are abundant in the chromosomes and mobile genetic elements of many bacteria. The low-copy-number staphylococcal multiresistance plasmid pSK41 encodes ParM, an Alp involved in efficient plasmid partitioning. pSK41 ParM has previously been shown to form filaments in vitro that are structurally dissimilar to those formed by other bacterial Alps. The mechanistic implications of these differences are not known. In order to gain insights into the properties and behavior of the pSK41 ParM Alp in vivo, we reconstituted the parMRC system in the ectopic rod-shaped host, E. coli, which is larger and more genetically amenable than the native host, Staphylococcus aureus. Fluorescence microscopy showed a functional fusion protein, ParM-YFP, formed straight filaments in vivo when expressed in isolation. Strikingly, however, in the presence of ParR and parC, ParM-YFP adopted a dramatically different structure, instead forming axial curved filaments. Time-lapse imaging and selective photobleaching experiments revealed that, in the presence of all components of the parMRC system, ParM-YFP filaments were dynamic in nature. Finally, molecular dissection of the parMRC operon revealed that all components of the system are essential for the generation of dynamic filaments.

  11. Proteinase-Activated Receptor 1 (PAR1 regulates leukemic stem cell functions.

    Directory of Open Access Journals (Sweden)

    Nicole Bäumer

    Full Text Available External signals that are mediated by specific receptors determine stem cell fate. The thrombin receptor PAR1 plays an important role in haemostasis, thrombosis and vascular biology, but also in tumor biology and angiogenesis. Its expression and function in hematopoietic stem cells is largely unknown. Here, we analyzed expression and function of PAR1 in primary hematopoietic cells and their leukemic counterparts. AML patients' blast cells expressed much lower levels of PAR1 mRNA and protein than CD34+ progenitor cells. Constitutive Par1-deficiency in adult mice did not affect engraftment or stem cell potential of hematopoietic cells. To model an AML with Par1-deficiency, we retrovirally introduced the oncogene MLL-AF9 in wild type and Par1-/- hematopoietic progenitor cells. Par1-deficiency did not alter initial leukemia development. However, the loss of Par1 enhanced leukemic stem cell function in vitro and in vivo. Re-expression of PAR1 in Par1-/- leukemic stem cells delayed leukemogenesis in vivo. These data indicate that Par1 contributes to leukemic stem cell maintenance.

  12. Proteinase-Activated Receptor 1 (PAR1) regulates leukemic stem cell functions.

    Science.gov (United States)

    Bäumer, Nicole; Krause, Annika; Köhler, Gabriele; Lettermann, Stephanie; Evers, Georg; Hascher, Antje; Bäumer, Sebastian; Berdel, Wolfgang E; Müller-Tidow, Carsten; Tickenbrock, Lara

    2014-01-01

    External signals that are mediated by specific receptors determine stem cell fate. The thrombin receptor PAR1 plays an important role in haemostasis, thrombosis and vascular biology, but also in tumor biology and angiogenesis. Its expression and function in hematopoietic stem cells is largely unknown. Here, we analyzed expression and function of PAR1 in primary hematopoietic cells and their leukemic counterparts. AML patients' blast cells expressed much lower levels of PAR1 mRNA and protein than CD34+ progenitor cells. Constitutive Par1-deficiency in adult mice did not affect engraftment or stem cell potential of hematopoietic cells. To model an AML with Par1-deficiency, we retrovirally introduced the oncogene MLL-AF9 in wild type and Par1-/- hematopoietic progenitor cells. Par1-deficiency did not alter initial leukemia development. However, the loss of Par1 enhanced leukemic stem cell function in vitro and in vivo. Re-expression of PAR1 in Par1-/- leukemic stem cells delayed leukemogenesis in vivo. These data indicate that Par1 contributes to leukemic stem cell maintenance.

  13. Measurement and analysis of high energy radiation through activation detectors. Application in dosimetry; Sur la mesure et l'analyse des rayonnements de haute energie par detecteurs a activation. Application a la dosimetrie

    Energy Technology Data Exchange (ETDEWEB)

    Sklavenitis, L. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1967-10-15

    This work is concerned with the possibility of measurement and analysis of radiation fluences within objects of small volume submitted to a high energy proton beam. The first part, consecrated to the establishment of a method of analysis, comprises a detailed study of the radiation nature and energy spectra as well as of the various dosimetry methods. In order to select a group of detectors, high energy nuclear reactions were systematically studied and for some of them cross sections were measured or calculated: for example the cross section of the reaction {sup 11}B (p,n) {sup 11}C between 150 and 3000 MeV and of the reaction {sup 34}S (p,2pn) {sup 32}P between 50 and 3000 MeV. The second part is relative to the application of the fore-mentioned analysis to radiation within a tissue equivalent phantom irradiated by 3 GeV protons. This analysis is sufficiently detailed to allow the reconstitution of the absorbed doses, the dose equivalent and, contingent on a better knowledge of the dose due to heavy particles, the quality factors. It allowed also to follow the evolution of the various dosimetric data as a function of the depth inside the phantom and to verify calculations already done by other researchers. The comparison of the measured doses and the corresponding detector activities revealed the possibility that some detectors could give directly the absorbed dose, or even the dose equivalent, by a simple activity measurement. (author) [French] Le travail porte sur la possibilite de mesure et d'analyse, a l'aide de detecteurs a activation, des fluences de rayonnements a l'interieur d'un objet de petit volume soumis a un faisceau de protons de tres haute energie. La premiere partie, consacree a la mise au point de la methode d'analyse des fluences, comporte une etude detaillee de la nature des rayonnements et de leurs spectres energetiques ainsi que des differentes methodes de dosimetrie. Pour arriver au choix d'un groupe de

  14. Measurement and analysis of high energy radiation through activation detectors. Application in dosimetry; Sur la mesure et l'analyse des rayonnements de haute energie par detecteurs a activation. Application a la dosimetrie

    Energy Technology Data Exchange (ETDEWEB)

    Sklavenitis, L [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1967-10-15

    This work is concerned with the possibility of measurement and analysis of radiation fluences within objects of small volume submitted to a high energy proton beam. The first part, consecrated to the establishment of a method of analysis, comprises a detailed study of the radiation nature and energy spectra as well as of the various dosimetry methods. In order to select a group of detectors, high energy nuclear reactions were systematically studied and for some of them cross sections were measured or calculated: for example the cross section of the reaction {sup 11}B (p,n) {sup 11}C between 150 and 3000 MeV and of the reaction {sup 34}S (p,2pn) {sup 32}P between 50 and 3000 MeV. The second part is relative to the application of the fore-mentioned analysis to radiation within a tissue equivalent phantom irradiated by 3 GeV protons. This analysis is sufficiently detailed to allow the reconstitution of the absorbed doses, the dose equivalent and, contingent on a better knowledge of the dose due to heavy particles, the quality factors. It allowed also to follow the evolution of the various dosimetric data as a function of the depth inside the phantom and to verify calculations already done by other researchers. The comparison of the measured doses and the corresponding detector activities revealed the possibility that some detectors could give directly the absorbed dose, or even the dose equivalent, by a simple activity measurement. (author) [French] Le travail porte sur la possibilite de mesure et d'analyse, a l'aide de detecteurs a activation, des fluences de rayonnements a l'interieur d'un objet de petit volume soumis a un faisceau de protons de tres haute energie. La premiere partie, consacree a la mise au point de la methode d'analyse des fluences, comporte une etude detaillee de la nature des rayonnements et de leurs spectres energetiques ainsi que des differentes methodes de dosimetrie. Pour arriver au choix d'un groupe de detecteurs, une etude systematique des

  15. Public Values

    DEFF Research Database (Denmark)

    Beck Jørgensen, Torben; Rutgers, Mark R.

    2015-01-01

    administration is approached in terms of processes guided or restricted by public values and as public value creating: public management and public policy-making are both concerned with establishing, following and realizing public values. To study public values a broad perspective is needed. The article suggest......This article provides the introduction to a symposium on contemporary public values research. It is argued that the contribution to this symposium represent a Public Values Perspective, distinct from other specific lines of research that also use public value as a core concept. Public...... a research agenda for this encompasing kind of public values research. Finally the contributions to the symposium are introduced....

  16. The double par locus of virulence factor pB171: DNA segregation is correlated with oscillation of ParA

    DEFF Research Database (Denmark)

    Ebersbach, G; Gerdes, K; Charbon, Gitte Ebersbach

    2001-01-01

    Prokaryotic plasmids and chromosomes encode partitioning (par) loci that segregate DNA to daughter cells before cell division. Recent database analyses showed that almost all known par loci encode an ATPase and a DNA-binding protein, and one or more cis-acting regions where the proteins act. All...

  17. ParABS Systems of the Four Replicons of Burkholderia cenocepacia: New Chromosome Centromeres Confer Partition Specificity†

    Science.gov (United States)

    Dubarry, Nelly; Pasta, Franck; Lane, David

    2006-01-01

    Most bacterial chromosomes carry an analogue of the parABS systems that govern plasmid partition, but their role in chromosome partition is ambiguous. parABS systems might be particularly important for orderly segregation of multipartite genomes, where their role may thus be easier to evaluate. We have characterized parABS systems in Burkholderia cenocepacia, whose genome comprises three chromosomes and one low-copy-number plasmid. A single parAB locus and a set of ParB-binding (parS) centromere sites are located near the origin of each replicon. ParA and ParB of the longest chromosome are phylogenetically similar to analogues in other multichromosome and monochromosome bacteria but are distinct from those of smaller chromosomes. The latter form subgroups that correspond to the taxa of their hosts, indicating evolution from plasmids. The parS sites on the smaller chromosomes and the plasmid are similar to the “universal” parS of the main chromosome but with a sequence specific to their replicon. In an Escherichia coli plasmid stabilization test, each parAB exhibits partition activity only with the parS of its own replicon. Hence, parABS function is based on the independent partition of individual chromosomes rather than on a single communal system or network of interacting systems. Stabilization by the smaller chromosome and plasmid systems was enhanced by mutation of parS sites and a promoter internal to their parAB operons, suggesting autoregulatory mechanisms. The small chromosome ParBs were found to silence transcription, a property relevant to autoregulation. PMID:16452432

  18. Economic study of an installation for uranium isotope separation by gaseous diffusion; Etude economique d'une installation de separation des isotopes de l'uranium par diffusion gazeuse

    Energy Technology Data Exchange (ETDEWEB)

    Bilous, O [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1958-07-01

    This report describes the major problems which arise in the choice of characteristics required in a gaseous diffusion installation for the separation of uranium isotopes. This choice depends largely on economic evaluations, and also on considerations of simplicity. The choice of working pressures and of the characteristics of the membrane are described, as are the possible alternatives regarding the structure of the stages and the problems of control. (author) [French] Ce rapport decrit les problemes majeurs qui se posent dans le choix des caracteristiques d'une installation de diffusion gazeuse destinee a la separation des isotopes de l'uranium. Ce choix depend en grande partie d'evaluations economiques et repose egalement sur des considerations de simplicite. On decrit ainsi le choix des pressions d'operation, celui des caracteristiques de la barriere, les alternatives possibles concernant la structure des etages et les problemes de regulation. (auteur)

  19. Liste des nouvelles et récits cités par ordre de publication

    OpenAIRE

    2016-01-01

    1879 : « The Mystery of Sasassa Valley » 1882 : « My Friend the Murderer » 1883 : « The Captain of the Polestar » « The Silver Hatchet » 1884 : « Joseph Habakuk Jephson’s Statement » 1885 : « The Man from Archangel » 1886 : « John Barrington Cowles » « A Literary Mosaic » 1887 : « A Study in Scarlet » « Uncle Jeremy’s Household » 1888 : « The Mystery of Cloomber » 1890 : « The Sign of Four » « The Ring of Thot » « The Great Keinplatz Experiment » « The Surgeon of Gaster Fell » 1891 : The Adve...

  20. The Politics of Storytelling: Unfolding the Multiple Layers of Politics in (P)AR Publications

    Science.gov (United States)

    Santos, Doris

    2012-01-01

    In the social sciences, inquiry into the relationship between storytelling and politics is based on a notion of historical continuity. One problem is the possible trap of inevitability inherent in this notion--that something which happened "had to happen". Hannah Arendt's conception of political theory as storytelling overcomes this trap,…

  1. Culture du résultat et pilotage par les indicateurs dans le secteur public

    OpenAIRE

    Chatelain-Ponroy, Stéphanie; Sponem, Samuel

    2008-01-01

    Depuis 20 ans, la question de la gestion de l’État est au cœur des réformes de l’administration dans tous les pays de l’OCDE. À cet égard, l’introduction d’une culture du résultat et des dispositifs de contrôle de gestion qui l’accompagnent dans l’administration publique telle qu’elle est mise en avant dans la LOLF, si elle peut avoir des effets positifs en termes d’évaluation des politiques publiques et d’incitation des agents, peut aussi engendrer des effets pervers. En la matière, l’expéri...

  2. Experimental study of contamination by inhalation of radioactive iodine aerosols. Biological balance; Etude experimentale de la contamination par inhalation d'aerosols d'iode radioactif bilan biologique

    Energy Technology Data Exchange (ETDEWEB)

    Marble, G [Commissariat a l' Energie Atomique, 92 - Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1968-07-01

    Several articles have been published concerning research into contamination produced by inhalation of radioactive iodine aerosols in monkeys. Results dealing with the biological balance of this contamination are presented and discussed in this report. (author) [French] L'etude experimentale de la contamination par inhalation d'aerosols d'iode radioactif effectuee chez le singe a fait l'objet de plusieurs publications. Les resultats concernant le bilan biologique de cette contamination sont presentes et discutes dans ce rapport. (auteur)

  3. Serum suPAR in patients with FSGS: trash or treasure?

    Science.gov (United States)

    Maas, Rutger J H; Deegens, Jeroen K J; Wetzels, Jack F M

    2013-07-01

    The urokinase-type plasminogen activator receptor (uPAR) has important functions in cell migration. uPAR can be shed from the cell membrane resulting in soluble uPAR (suPAR). Further cleavage gives rise to shorter fragments with largely unknown functions. Recent studies have demonstrated that both overexpression of uPAR on podocytes and the administration of suPAR cause proteinuria in mice. The common pathogenic mechanism involves the activation of podocyte β3-integrin. Increased activation of β3-integrin is also observed in patients with focal and segmental glomerulosclerosis (FSGS). These observations form the basis for the hypothesis that suPAR may be the circulating factor causing FSGS. A recent study fosters this idea by demonstrating increased suPAR levels in the serum of patients with FSGS and reporting an association with recurrence after transplantation and response to plasmapheresis. However, this study was heavily biased, and subsequent studies have given conflicting results. Although the experimental work is very suggestive, at present there is no proof that any known human suPAR fragment causes FSGS in humans. We therefore suggest that the measurement of suPAR using currently available assays has absolutely no value at the present time in decision-making in routine clinical practice.

  4. PAR-2 expression in the gingival crevicular fluid reflects chronic periodontitis severity

    Directory of Open Access Journals (Sweden)

    Henrique FUKUSHIMA

    Full Text Available Abstract Recent studies investigating protease-activated receptor type 2 (PAR-2 suggest an association between the receptor and periodontal inflammation. It is known that gingipain, a bacterial protease secreted by the important periodontopathogen Porphyromonas gingivalis can activate PAR-2. Previous studies by our group found that PAR-2 is overexpressed in the gingival crevicular fluid (GCF of patients with moderate chronic periodontitis (MP. The present study aimed at evaluating whether PAR-2 expression is associated with chronic periodontitis severity. GCF samples and clinical parameters, including plaque and bleeding on probing indices, probing pocket depth and clinical attachment level, were collected from the control group (n = 19 at baseline, and from MP patients (n = 19 and severe chronic periodontitis (SP (n = 19 patients before and 6 weeks after periodontal non-surgical treatment. PAR-2 and gingipain messenger RNA (mRNA in the GCF of 4 periodontal sites per patient were evaluated by Reverse Transcription Polymerase Chain Reaction (RT-qPCR. PAR-2 and gingipain expressions were greater in periodontitis patients than in control group patients. In addition, the SP group presented increased PAR-2 and gingipain mRNA levels, compared with the MP group. Furthermore, periodontal treatment significantly reduced (p <0.05 PAR-2 expression in patients with periodontitis. In conclusion, PAR-2 is associated with chronic periodontitis severity and with gingipain levels in the periodontal pocket, thus suggesting that PAR-2 expression in the GCF reflects the severity of destruction during periodontal infection.

  5. Structures of actin-like ParM filaments show architecture of plasmid-segregating spindles.

    Science.gov (United States)

    Bharat, Tanmay A M; Murshudov, Garib N; Sachse, Carsten; Löwe, Jan

    2015-07-02

    Active segregation of Escherichia coli low-copy-number plasmid R1 involves formation of a bipolar spindle made of left-handed double-helical actin-like ParM filaments. ParR links the filaments with centromeric parC plasmid DNA, while facilitating the addition of subunits to ParM filaments. Growing ParMRC spindles push sister plasmids to the cell poles. Here, using modern electron cryomicroscopy methods, we investigate the structures and arrangements of ParM filaments in vitro and in cells, revealing at near-atomic resolution how subunits and filaments come together to produce the simplest known mitotic machinery. To understand the mechanism of dynamic instability, we determine structures of ParM filaments in different nucleotide states. The structure of filaments bound to the ATP analogue AMPPNP is determined at 4.3 Å resolution and refined. The ParM filament structure shows strong longitudinal interfaces and weaker lateral interactions. Also using electron cryomicroscopy, we reconstruct ParM doublets forming antiparallel spindles. Finally, with whole-cell electron cryotomography, we show that doublets are abundant in bacterial cells containing low-copy-number plasmids with the ParMRC locus, leading to an asynchronous model of R1 plasmid segregation.

  6. PAR-1 contributes to the innate immune response during viral infection

    Science.gov (United States)

    Antoniak, Silvio; Owens, A. Phillip; Baunacke, Martin; Williams, Julie C.; Lee, Rebecca D.; Weithäuser, Alice; Sheridan, Patricia A.; Malz, Ronny; Luyendyk, James P.; Esserman, Denise A.; Trejo, JoAnn; Kirchhofer, Daniel; Blaxall, Burns C.; Pawlinski, Rafal; Beck, Melinda A.; Rauch, Ursula; Mackman, Nigel

    2013-01-01

    Coagulation is a host defense system that limits the spread of pathogens. Coagulation proteases, such as thrombin, also activate cells by cleaving PARs. In this study, we analyzed the role of PAR-1 in coxsackievirus B3–induced (CVB3-induced) myocarditis and influenza A infection. CVB3-infected Par1–/– mice expressed reduced levels of IFN-β and CXCL10 during the early phase of infection compared with Par1+/+ mice that resulted in higher viral loads and cardiac injury at day 8 after infection. Inhibition of either tissue factor or thrombin in WT mice also significantly increased CVB3 levels in the heart and cardiac injury compared with controls. BM transplantation experiments demonstrated that PAR-1 in nonhematopoietic cells protected mice from CVB3 infection. Transgenic mice overexpressing PAR-1 in cardiomyocytes had reduced CVB3-induced myocarditis. We found that cooperative signaling between PAR-1 and TLR3 in mouse cardiac fibroblasts enhanced activation of p38 and induction of IFN-β and CXCL10 expression. Par1–/– mice also had decreased CXCL10 expression and increased viral levels in the lung after influenza A infection compared with Par1+/+ mice. Our results indicate that the tissue factor/thrombin/PAR-1 pathway enhances IFN-β expression and contributes to the innate immune response during single-stranded RNA viral infection. PMID:23391721

  7. Par-4-mediated recruitment of Amida to the actin cytoskeleton leads to the induction of apoptosis

    International Nuclear Information System (INIS)

    Boosen, Meike; Vetterkind, Susanne; Koplin, Ansgar; Illenberger, Susanne; Preuss, Ute

    2005-01-01

    Par-4 (prostate apoptosis response-4) sensitizes cells to apoptotic stimuli, but the exact mechanisms are still poorly understood. Using Par-4 as bait in a yeast two-hybrid screen, we identified Amida as a novel interaction partner, a ubiquitously expressed protein which has been suggested to be involved in apoptotic processes. Complex formation of Par-4 and Amida occurs in vitro and in vivo and is mediated via the C-termini of both proteins, involving the leucine zipper of Par-4. Amida resides mainly in the nucleus but displays nucleo-cytoplasmic shuttling in heterokaryons. Upon coexpression with Par-4 in REF52.2 cells, Amida translocates to the cytoplasm and is recruited to actin filaments by Par-4, resulting in enhanced induction of apoptosis. The synergistic effect of Amida/Par-4 complexes on the induction of apoptosis is abrogated when either Amida/Par-4 complex formation or association of these complexes with the actin cytoskeleton is impaired, indicating that the Par-4-mediated relocation of Amida to the actin cytoskeleton is crucial for the pro-apoptotic function of Par-4/Amida complexes in REF52.2 cells. The latter results in enhanced phosphorylation of the regulatory light chain of myosin II (MLC) as has previously been shown for Par-4-mediated recruitment of DAP-like kinase (Dlk), suggesting that the recruitment of nuclear proteins involved in the regulation of apoptotic processes to the actin filament system by Par-4 represents a potent mechanism how Par-4 can trigger apoptosis

  8. Bacterial mitosis: Partitioning protein ParA oscillates in spiral-shaped structures and positions plasmids at mid-cell

    DEFF Research Database (Denmark)

    Ebersbach, G.; Gerdes, Kenn

    2004-01-01

    The par2 locus of Escherichia coli plasmid pB171 encodes oscillating ATPase ParA, DNA binding protein ParB and two cis-acting DNA regions to which ParB binds (parC1 and parC2). Three independent techniques were used to investigate the subcellular localization of plasmids carrying par2. In cells......A-GFP oscillated in spiral-shaped structures. Amino acid substitutions in ParA simultaneously abolished ParA spiral formation, oscillation and either plasmid localization or plasmid separation at mid-cell. Therefore, our results suggest that ParA spirals position plasmids at the middle of the bacterial nucleoid...

  9. Envenimation mortelle par morsure de serpent chez une femme ...

    African Journals Online (AJOL)

    Les auteurs rapportent un cas de morsure de serpent au niveau de la face chez une femme enceinte, dont l'évolution a été marquée par l'installation d'un oedème cervico-facial nécessitant une trachéotomie en urgence, et une mort foetale in utero avec troubles de l'hémostase responsable du décès maternel dans un ...

  10. Analysis of clinical features and visual outcomes of pars planitis.

    Science.gov (United States)

    Berker, Nilufer; Sen, Emine; Elgin, Ufuk; Atilgan, Cemile Ucgul; Dursun, Erdem; Yilmazbas, Pelin

    2018-04-01

    To evaluate the demographic characteristics, clinical features, treatment and outcomes of patients with pars planitis in a tertiary referral center in Turkey. Medical records of patients with pars planitis were retrospectively reviewed. The data including demographic and ocular features and treatment outcomes were recorded. The distribution of clinical findings and complications were evaluated according to age and gender groups. The changes in final BCVA compared to the initial BCVA were noted. Statistical analysis was performed using SPSS software (Version 18.0, SPSS Inc., Chicago, USA). Twenty-seven patients (54 eyes) were included in this study. 16 patients were male (59.3%), and 11 were female (40.7%). Mean age at diagnosis was 12.84 ± 8.26 (range 4-36) years. Mean follow-up period was 61.3 ± 52.15 (range 9-172) months. Mean BCVA was 0.58 ± 0.36 (range 0.03-1.00) (0.40 ± 0.45 logMAR) at presentation, and 0.81 ± 0.28 (range 0.10-1.00) (0.14 ± 0.27 logMAR) at final visit (P = 0.001). Vitreous inflammation (100%), vitreous haze (92.6%), snowballs (74.1%), snowbanks (66.7%), anterior chamber cells (66.7%) and peripheral retinal vascular sheathing (48.1%) were the most common presentations. Ocular complications included vitreous condensation (51.9%), cystoid macular edema (22.2%), cataract (18.5%), inferior peripheral retinal detachment (11.1%), glaucoma (5.6%) and vitreous hemorrhage (3.7%). Treatments included topical, periocular, intravitreal and systemic corticosteroids, immunosuppressives, peripheral laser photocoagulation and pars plana vitrectomy when needed. Pars planitis is an idiopathic chronic intermediate uveitis mostly affecting children and adolescents. In spite of its chronic nature with high potential of causing ocular complications, adequate treatment and close follow-up lead to favorable visual outcomes.

  11. Cartographie par carroyage et précision spatiale

    Directory of Open Access Journals (Sweden)

    Patrice LANGLOIS

    1998-03-01

    Full Text Available Dans le cadre d'une cartographie par carroyage, on étudie la désagrégation de variables zonales, en revenant sur l'hypothèse de l'équirépartition spatiale des populations. L'objectif est d'approcher des règles différenciées de désagrégation des variables en fusionnant des plans d'information de nature morphologique, topologique et environnementale.

  12. PET imaging of urokinase-type plasminogen activator receptor (uPAR) in prostate cancer

    DEFF Research Database (Denmark)

    Skovgaard, Dorthe; Persson, Morten; Kjaer, Andreas

    2016-01-01

    Overexpression of urokinase-type plasminogen activator receptors (uPAR) represents an important biomarker for aggressiveness in most common malignant diseases, including prostate cancer (PC). Accordingly, uPAR expression either assessed directly in malignant PC tissue or assessed directly in plasma...... and prognostic imaging method. In this review, we will focus on the recent development of uPAR PET and the relevance within prostate cancer imaging. Novel antibody and small-molecule radiotracers-targeting uPAR, including a series of uPAR-targeting PET ligands, based on the high affinity peptide ligand AE105......, have been synthesized and tested in vitro and in vivo in preclinical murine xenograft models and, recently, in a first-ever clinical uPAR PET study in cancer patients, including patients with PC. In this phase I study, a high and specific uptake of the tracer 64Cu-DOTA-AE105 was found in both primary...

  13. Paracrine Apoptotic Effect of p53 Mediated by Tumor Suppressor Par-4

    Directory of Open Access Journals (Sweden)

    Ravshan Burikhanov

    2014-01-01

    Full Text Available The guardian of the genome, p53, is often mutated in cancer and may contribute to therapeutic resistance. Given that p53 is intact and functional in normal tissues, we harnessed its potential to inhibit the growth of p53-deficient cancer cells. Specific activation of p53 in normal fibroblasts selectively induced apoptosis in p53-deficient cancer cells. This paracrine effect was mediated by p53-dependent secretion of the tumor suppressor Par-4. Accordingly, the activation of p53 in normal mice, but not p53−/− or Par-4−/− mice, caused systemic elevation of Par-4, which induced apoptosis of p53-deficient tumor cells. Mechanistically, p53 induced Par-4 secretion by suppressing the expression of its binding partner, UACA, which sequesters Par-4. Thus, normal cells can be empowered by p53 activation to induce Par-4 secretion for the inhibition of therapy-resistant tumors.

  14. The Modular Teaching Organization System (MTOS from the perspective of graduates in the municipality of Breves - Pará

    Directory of Open Access Journals (Sweden)

    João Marcelino Pantoja Rodrigues

    2018-04-01

    Full Text Available This work is the result of a research in education. It analyzes contributions and limitations of the Modular Teaching Organization System in the education of young people in the rural environment of the municipality of Breves, Pará, from the perceptions of high school graduates. It considers the needs and expectations of this public. The research was carried out through a qualitative field study in the Mainardi village, a pioneer community in the offering of this program in the rural environment of Breves. The main technique of data collection is a semi-structured interview with six young graduates, whose responses were treated in light of the thematic content analysis. The results point to the affirmation of the importance of this program as the only alternative of access to secondary education for a large portion of young people from the rural environment of Pará. At the same time, the results reveal the mismatch of the experience in relation to the needs and expectations of this public of secondary education.

  15. Public lighting.

    NARCIS (Netherlands)

    Schreuder, D.A.

    1986-01-01

    The function of public lighting and the relationship between public lighting and accidents are considered briefly as aspects of effective countermeasures. Research needs and recent developments in installation and operational described. Public lighting is an efficient accident countermeasure, but

  16. Four cases of endophthalmitis after 25-gauge pars plana vitrectomy

    Directory of Open Access Journals (Sweden)

    Mutoh T

    2012-08-01

    Full Text Available Tetsuya Mutoh, Koji Kadoya, Makoto ChikudaDepartment of Ophthalmology, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, JapanAbstract: We report our recent experience with four cases of endophthalmitis (one male, three females after 25-gauge pars plana vitrectomy (PPV. One was a case of persistent cystoid macular edema caused by branch retinal vein occlusion, whereas the remaining three were cases of epiretinal membrane. Preoperative antibiotics before the first PPV procedure were not administered in three of the four cases. Endophthalmitis occurred 2–4 days after the first procedure in all cases, for which ceftazidime 2.0 mg/0.1 mL and vancomycin 1.0 mg/0.1 mL were injected into the vitreous cavity. This was followed by emergent 20-gauge PPV and intraocular lens removal using an infusion fluid containing ceftazidime and vancomycin. After the second PPV procedure, progress was good in three cases while retinal detachment occurred in the remaining case one month after surgery; this case required a third PPV procedure. Final best-corrected visual acuity ranged from 20/100 to 20/25 for the four cases. Bacterial cultures were negative after the second PPV procedure in all cases. In conclusion, postoperative endophthalmitis occurred in four of 502 cases (0.80% that underwent 25-gauge PPV at our hospital. It is important to minimize the incidence of endophthalmitis after 25-gauge PPV.Keywords: 25-gauge pars plana vitrectomy, endophthalmitis, incidence

  17. Stress reactions involving the pars interarticularis in young athletes

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, D.W.; Wiltse, L.L.; Dingeman, R.D.; Hayes, M.

    A stress reaction involving the pars interarticularis of the lumbar spine was confirmed in seven young athletes with a positive technetium pyrophosphate bone scan. No pars defects were detectable on their lumbosacral roentgenograms, which included oblique views. The return to normal levels of radioactive uptake on repeat bone scans correlated closely with their clinical course. If the bony reaction is recognized early, it may heal at a subroentgenographic level and prevent the development of lumbar spondylolysis. These early lesions usually show unilateral increased uptake at one lumbar level on the bone scan and, initially, the athlete localizes the pain to the corresponding unilateral lumbar paraspinous area. The ''one-legged hyperextension test'' is positive on the ipsilateral side and aggravates the pain. Treatment consists of avoiding the aggravating activities and resting. The average time for return to pain-free competition was 7.3 months. These developing defects may be the source of considerable prolonged disability in the young athlete, particularly if undiagnosed and untreated.

  18. Stress reactions involving the pars interarticularis in young athletes

    International Nuclear Information System (INIS)

    Jackson, D.W.; Wiltse, L.L.; Dingeman, R.D.; Hayes, M.

    1981-01-01

    A stress reaction involving the pars interarticularis of the lumbar spine was confirmed in seven young athletes with a positive technetium pyrophosphate bone scan. No pars defects were detectable on their lumbosacral roentgenograms, which included oblique views. The return to normal levels of radioactive uptake on repeat bone scans correlated closely with their clinical course. If the bony reaction is recognized early, it may heal at a subroentgenographic level and prevent the development of lumbar spondylolysis. These early lesions usually show unilateral increased uptake at one lumbar level on the bone scan and, initially, the athlete localizes the pain to the corresponding unilateral lumbar paraspinous area. The ''one-legged hyperextension test'' is positive on the ipsilateral side and aggravates the pain. Treatment consists of avoiding the aggravating activities and resting. The average time for return to pain-free competition was 7.3 months. These developing defects may be the source of considerable prolonged disability in the young athlete, particularly if undiagnosed and untreated

  19. Compositions de revêtement réticulables par bombardement électronique. Première Partie : Caractéristiques générales du procédé Forming Crosslinkable Coatings by Electron Bombardement. Part One : General Features of the Process

    Directory of Open Access Journals (Sweden)

    Miléo J. -C.

    2006-11-01

    Full Text Available L'utilisation des accélérateurs d'électrons de moyenne énergie pour le durcissement et l'insolubilisation des peintures et vernis est décrite en analysant plus particulièrement l'aspect physico-chimique du procédé. On examine spécialement - l'action du rayonnement sur la matière; - les aspects généraux de la polymérisation radiochimique ; - l'application de la polymérisation sous radiation au séchage des vernis. On aborde ensuite rapidement les problèmes liés au choix du rayonnement et à l'influence de l'oxygène de l'air. Cet exposé se termine par la description d'un accélérateur d'électrons et d'une méthode calométrique de dosimétrie. The use of medium-power electron accelerators ta cure points and varnishes and to make them insoluble is described by making a special analysis of the physico-che-mical aspect of the process. The following points in particular are examined - the effect of radiation on matter; - general aspects of radiochemical polymerization ; - the application of radiation polymerization ta varnish drying. A quick review is then made of problems linked to the choice of radiation and to the influence of the oxygen in air. The article ends with a description of an electron accelerator and a calorimetric dosimetering method.

  20. Health problems raised by the elimination of radioactive wastes and nuclear accidents; Problemes sanitaires poses par l'elimination des dechets radioactifs et par les accidents nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    Jammet, H.; Mechali, D.; Dousset, M. [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1964-07-01

    The rapid development of nuclear energy demands an urgent solution to the health problems arising from the discharge into the environment of radioactive residues produced by nuclear installations. - To be able to evaluate the risks run by the population and to fix tolerance limits for waste discharge, it is necessary to possess an exact knowledge of the course taken by the radioelements discharged, from their source until they reach man. The incorporation of radioelements in food cycles is the first risk to take into consideration. The factors involved in all stages of this transmission must be foreseen, whether they concern physical or biological media, because of their continuity and their interdependence. Finally, socio-economic and dietetic data must be collected in order that the risks and tolerance levels estimated are based on concrete and experimental rather than theoretical knowledge. The risk of nuclear accidents in the atomic industry, although very improbable, must be taken into consideration because of the seriousness of their consequences. The health problems arise in the field of professional hygiene on the one hand and in that of public hygiene on the other. In the first field the risk is two-fold and involves irradiation and contamination. The public sphere is reduced essentially to the risk of contamination by radioactive substances accidentally released in the surrounding medium. The health studies to be conducted in this field therefore include research not only on irradiation or contamination therapeutics but also on the transfer of radioelements from the accident site to man, mainly through food cycles, in their physical and in their biological components. Studies of this kind form the basis of decisions in the health field which would have to be taken in the case of an accident. (authors) [French] Le developpement rapide de l'energie nucleaire rend urgente la solution des problemes sanitaires poses par le rejet dans le milieu ambiant des

  1. Réduction du risque d'infection par le VIH au Botswana - essais ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Au Botswana, ce sont les jeunes femmes qui sont le plus touchées par les nouvelles infections par le VIH. Le présent projet a pour but de réduire le nombre de nouveaux cas d'infection par le VIH, en particulier chez les femmes de 15 à 29 ans. Bien que l'on recense des cas de VIH/sida dans la plupart des régions du ...

  2. PAR-2 expression in the gingival crevicular fluid reflects chronic periodontitis severity.

    Science.gov (United States)

    Fukushima, Henrique; Alves, Vanessa Tubero Euzebio; Carvalho, Verônica Franco de; Ambrósio, Lucas Macedo Batitucci; Eichler, Rosangela Aparecida Dos Santos; Carvalho, Maria Helena Catelli de; Saraiva, Luciana; Holzhausen, Marinella

    2017-01-26

    Recent studies investigating protease-activated receptor type 2 (PAR-2) suggest an association between the receptor and periodontal inflammation. It is known that gingipain, a bacterial protease secreted by the important periodontopathogen Porphyromonas gingivalis can activate PAR-2. Previous studies by our group found that PAR-2 is overexpressed in the gingival crevicular fluid (GCF) of patients with moderate chronic periodontitis (MP). The present study aimed at evaluating whether PAR-2 expression is associated with chronic periodontitis severity. GCF samples and clinical parameters, including plaque and bleeding on probing indices, probing pocket depth and clinical attachment level, were collected from the control group (n = 19) at baseline, and from MP patients (n = 19) and severe chronic periodontitis (SP) (n = 19) patients before and 6 weeks after periodontal non-surgical treatment. PAR-2 and gingipain messenger RNA (mRNA) in the GCF of 4 periodontal sites per patient were evaluated by Reverse Transcription Polymerase Chain Reaction (RT-qPCR). PAR-2 and gingipain expressions were greater in periodontitis patients than in control group patients. In addition, the SP group presented increased PAR-2 and gingipain mRNA levels, compared with the MP group. Furthermore, periodontal treatment significantly reduced (p periodontitis. In conclusion, PAR-2 is associated with chronic periodontitis severity and with gingipain levels in the periodontal pocket, thus suggesting that PAR-2 expression in the GCF reflects the severity of destruction during periodontal infection.

  3. Le projet HANS KAÏ : une approche communautaire visant à améliorer la santé et le bien-être grâce au soutien par les pairs

    Directory of Open Access Journals (Sweden)

    Alexandra Henteleff

    2018-01-01

    Full Text Available Introduction : Le modèle HANS KAÏ est une intervention de promotion de la santé originale qui vise à améliorer la santé des participants en ciblant les comportements interdépendants de prévention des maladies chroniques grâce au soutien par les pairs et au renforcement des réseaux de soutien social. L'objectif de notre étude était de mesurer l’efficacité du modèle HANS KAÏ en contexte urbain canadien. Méthodologie : Nous avons utilisé un modèle de recherche interventionnelle à méthodes mixtes appliqué à plusieurs sites entre novembre 2010 et avril 2015. Les données ont été recueillies au moyen de sondages auprès des participants et d’entrevues en personne au début de l'étude puis à 6, 12 et 24 mois. Les participants se sont réunis en groupes au moins une fois par mois durant la période de recherche afin de surveiller eux-mêmes leurs indicateurs de santé, de préparer et de partager une collation saine, de participer à une activité physique, d’établir un objectif en matière de mode de vie sain (facultatif et d'avoir une activité de convivialité. Résultats : Des améliorations statistiquement significatives de la santé mentale ont été constatées avant et après le programme, et 66 % des participants ont fait état de changements de comportement précis résultant de la participation au projet HANS. D’autres effets positifs sur la santé ont été constatés : un soutien par les pairs, l’acquisition de connaissances précises en matière de santé, l’inspiration, la motivation et la prise de responsabilité, l’autonomisation découlant du suivi de ses propres indicateurs de santé, la possibilité de rompre l’isolement social et enfin une meilleure connaissance de la façon d'avoir accès aux services. Conclusion : C'est la nécessité de trouver des moyens innovants pour favoriser la prévention et la gestion des maladies chroniques qui a motivé la mise en oeuvre et l’évaluation du

  4. Heavy element concentration determination by the x-ray fluorescence analysis using radioisotope {gamma}-ray sources; Dosage d'elements lourds par fluorescence X utilisant des radio-sources de rayons gamma

    Energy Technology Data Exchange (ETDEWEB)

    Enomoto, S [Commissariat a l' Energie Atomique, Dir. des Materiaux et des Combustibles Nucleaires, Saclay (France). Centre d' Etudes Nucleaires

    1968-07-01

    A theoretical and experimental study has been made on the fluorescence analysis of high atomic number element, using {gamma}-ray sources for excitation and characteristic K X-rays for the measurement. The choice of the proper {gamma}-ray energy according to the conditions of the determination is considered. The author has studied the usefulness of using the backscattered {gamma}-rays as a correction mean for matrix and grain-size effects. Sources of {sup 153}Gd, {sup 57}Co, {sup 137}Cs have been used for excitation using collimated geometries. Concentration measurements of tungsten in steel, tungsten and lead in aqueous solution, PbS in SiO{sub 2}-PbS powder mixtures have been done, as well as thickness evaluation of gold layers on copper. A precision of about 0.2 per cent (abs.) is obtained for lead determination in light matrixes. A probe design is proposed for the continuous determination of lead in aqueous solutions. (author) [French] On etudie de maniere theorique et experimentale l'analyse d'elements a nombre atomique eleve par fluorescence en utilisant des sources de rayons {gamma} pour l'excitation, et des rayons-X K caracteristiques pour la mesure. On considere le choix de l'energie appropriee des rayons {gamma} suivant les conditions experimentales. L'utilite d'employer les rayons {gamma} retrodiffuses pour corriger les effets de la matrice et de la dimension des grains est etudiee. Des sources de {sup 153}Gd, de {sup 57}Co et de {sup 137}Cs a geometrie collimatee ont ete utilisees pour l'excitation. Des mesures de la concentration du tungstene dans l'acier, du tungstene et du plomb en solutions aqueuses, et du PbS dans des melanges de poudre SiO{sub 2}-PbS ont ete entreprises ainsi que l'evaluation de l'epaisseur des couches d'or sur le cuivre. On obtient une precision d'environ 0,2 pour cent (en absolu) pour la determination du plomb dans des matrices legeres. On propose un modele de sonde pour la determination en continu du plomb en solution aqueuse

  5. Publications 2004

    Directory of Open Access Journals (Sweden)

    2005-03-01

    Full Text Available Fabienne Blaise- F. Blaise, P. Judet de La Combe et Ph. Rousseau (éds. : Le Métier du mythe. Lectures d'Hésiode (Villeneuve d'Ascq, PUS, 1996 - traduction chinoise à paraître aux éditions Huaxia Publishing House of China, Pékin, en 2005.Jean Bollack- La Muerte de Antigona. La tragedia de Creonte. Traduction en espagnol de La Mort d'Antigone (Paris, PUF, 1999 par Arnaud Pons et de Xavier Riu, Arena Libros, coll. Tempo al Tempo, Madrid 2004,  144 p. -  Sentido contra sentido. ¿ Como se lee ?...

  6. Organizational and Managerial Challenges of Reforming Slovenian Public Agencies

    Directory of Open Access Journals (Sweden)

    Kovač Polonca

    2014-11-01

    Full Text Available Introduction: Agencies are among the key contemporary public organizations, prospering within reforms carried out worldwide to increase professionalism and rationalism in public administration (PA. Hence, countries have been establishing agencies and delegating them public tasks in order to achieve expertise-based instead of politically-driven and thus more efficient public policies. In such context, the present article addresses the most important strategic documents related to public administration reform (PAR in Slovenia, analyzing their goals in terms of agencification and the main implementation results and gaps.

  7. Publications | Page 12 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  8. Publications | Page 178 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  9. Publications | Page 39 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  10. Publications | Page 130 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  11. Publications | Page 17 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Publication du rapport de BSR sur le travail des enfants en Birmanie. Le CRDI finance plusieurs projets de recherche sur les facteurs expliquant le travail des enfants, incluant le rapport intitulé 'Child labor in Myanmar's Garment Sector' écrit récemment par l'organisme Business for Social Responsibility (BSR).

  12. Publications | Page 25 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  13. Publications | Page 4 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  14. Publications | Page 131 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  15. Publications | Page 18 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  16. Publications | Page 96 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  17. Publications | Page 117 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  18. Publications | Page 222 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  19. Publications | Page 99 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  20. Publications | Page 65 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  1. Publications | Page 76 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  2. Publications | Page 139 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  3. Publications | Page 142 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  4. Publications | Page 144 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  5. Publications | Page 67 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  6. Publications | Page 55 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  7. Publications | Page 206 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  8. Publications | Page 182 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  9. Publications | Page 183 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  10. Publications | Page 208 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  11. Publications | Page 32 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  12. Publications | Page 73 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  13. Publications | Page 87 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  14. Proceedings of the workshop on siting of radioactive waste repositories in geological formations. Compte rendu d'une reunion de travail sur le choix des sites des depots de dechets radioactifs dans les formations geologiques

    Energy Technology Data Exchange (ETDEWEB)

    1981-01-01

    The objectives of this workshop were: to review the approaches used in NEA Member countries for the siting of repositories; to consider what information is required to determine whether a particular location is suitable as a disposal site; to review the technical means that can be used to obtain the necessary information; to discuss possible approaches for effectively communicating to the public the results of the site characterisation process. The papers and discussions at the meeting are recorded in these proceedings which provide a synthesis of the present thinking in this field.

  15. The polarity protein Par6 is coupled to the microtubule network during molluscan early embryogenesis

    Energy Technology Data Exchange (ETDEWEB)

    Homma, Taihei [Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Shimizu, Miho [Kuroda Chiromorphology Team, ERATO-SORST, JST, Komaba, Meguro-ku, Tokyo 153-8902 (Japan); Kuroda, Reiko, E-mail: ckuroda@mail.ecc.u-tokyo.ac.jp [Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Kuroda Chiromorphology Team, ERATO-SORST, JST, Komaba, Meguro-ku, Tokyo 153-8902 (Japan); Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Komaba, Meguro-ku, Tokyo 153-8902 (Japan)

    2011-01-07

    Research highlights: {yields} The cDNAs encoding Par6 and aPKC homologues were cloned from the snail Lymnaea stagnalis. {yields} L. stagnalis Par6 directly interacts with tubulin and microtubules and localizes to the microtubule cytoskeleton during the early embryogenesis. {yields} Identical sequence and localization of LsPar6 for the dextral and the sinistral snails exclude the possibility of the gene being the primary determinant of body handedness. -- Abstract: Cell polarity, which directs the orientation of asymmetric cell division and segregation of fate determinants, is a fundamental feature of development and differentiation. Regulators of polarity have been extensively studied, and the critical importance of the Par (partitioning-defective) complex as the polarity machinery is now recognized in a wide range of eukaryotic systems. The Par polarity module is evolutionarily conserved, but its mechanism and cooperating factors vary among different systems. Here we describe the cloning and characterization of a pond snail Lymnaea stagnalis homologue of partitioning-defective 6 (Lspar6). The protein product LsPar6 shows high affinity for microtubules and localizes to the mitotic apparatus during embryonic cell division. In vitro assays revealed direct binding of LsPar6 to tubulin and microtubules, which is the first evidence of the direct interaction between the two proteins. The interaction is mediated by two distinct regions of LsPar6 both located in the N-terminal half. Atypical PKC, a functional partner of Par6, was also found to localize to the mitotic spindle. These results suggest that the L. stagnalis Par complex employs the microtubule network in cell polarity processes during the early embryogenesis. Identical sequence and localization of LsPar6 for the dextral and the sinistral snails exclude the possibility of the gene being the primary determinant of handedness.

  16. The polarity protein Par6 is coupled to the microtubule network during molluscan early embryogenesis

    International Nuclear Information System (INIS)

    Homma, Taihei; Shimizu, Miho; Kuroda, Reiko

    2011-01-01

    Research highlights: → The cDNAs encoding Par6 and aPKC homologues were cloned from the snail Lymnaea stagnalis. → L. stagnalis Par6 directly interacts with tubulin and microtubules and localizes to the microtubule cytoskeleton during the early embryogenesis. → Identical sequence and localization of LsPar6 for the dextral and the sinistral snails exclude the possibility of the gene being the primary determinant of body handedness. -- Abstract: Cell polarity, which directs the orientation of asymmetric cell division and segregation of fate determinants, is a fundamental feature of development and differentiation. Regulators of polarity have been extensively studied, and the critical importance of the Par (partitioning-defective) complex as the polarity machinery is now recognized in a wide range of eukaryotic systems. The Par polarity module is evolutionarily conserved, but its mechanism and cooperating factors vary among different systems. Here we describe the cloning and characterization of a pond snail Lymnaea stagnalis homologue of partitioning-defective 6 (Lspar6). The protein product LsPar6 shows high affinity for microtubules and localizes to the mitotic apparatus during embryonic cell division. In vitro assays revealed direct binding of LsPar6 to tubulin and microtubules, which is the first evidence of the direct interaction between the two proteins. The interaction is mediated by two distinct regions of LsPar6 both located in the N-terminal half. Atypical PKC, a functional partner of Par6, was also found to localize to the mitotic spindle. These results suggest that the L. stagnalis Par complex employs the microtubule network in cell polarity processes during the early embryogenesis. Identical sequence and localization of LsPar6 for the dextral and the sinistral snails exclude the possibility of the gene being the primary determinant of handedness.

  17. Paternal age related schizophrenia (PARS): Latent subgroups detected by k-means clustering analysis.

    Science.gov (United States)

    Lee, Hyejoo; Malaspina, Dolores; Ahn, Hongshik; Perrin, Mary; Opler, Mark G; Kleinhaus, Karine; Harlap, Susan; Goetz, Raymond; Antonius, Daniel

    2011-05-01

    Paternal age related schizophrenia (PARS) has been proposed as a subgroup of schizophrenia with distinct etiology, pathophysiology and symptoms. This study uses a k-means clustering analysis approach to generate hypotheses about differences between PARS and other cases of schizophrenia. We studied PARS (operationally defined as not having any family history of schizophrenia among first and second-degree relatives and fathers' age at birth ≥ 35 years) in a series of schizophrenia cases recruited from a research unit. Data were available on demographic variables, symptoms (Positive and Negative Syndrome Scale; PANSS), cognitive tests (Wechsler Adult Intelligence Scale-Revised; WAIS-R) and olfaction (University of Pennsylvania Smell Identification Test; UPSIT). We conducted a series of k-means clustering analyses to identify clusters of cases containing high concentrations of PARS. Two analyses generated clusters with high concentrations of PARS cases. The first analysis (N=136; PARS=34) revealed a cluster containing 83% PARS cases, in which the patients showed a significant discrepancy between verbal and performance intelligence. The mean paternal and maternal ages were 41 and 33, respectively. The second analysis (N=123; PARS=30) revealed a cluster containing 71% PARS cases, of which 93% were females; the mean age of onset of psychosis, at 17.2, was significantly early. These results strengthen the evidence that PARS cases differ from other patients with schizophrenia. Hypothesis-generating findings suggest that features of PARS may include a discrepancy between verbal and performance intelligence, and in females, an early age of onset. These findings provide a rationale for separating these phenotypes from others in future clinical, genetic and pathophysiologic studies of schizophrenia and in considering responses to treatment. Copyright © 2011 Elsevier B.V. All rights reserved.

  18. Electron microscope study of vacancy clusters produced by quenching in magnesium; Etude par microscopie electronique des amas de lacunes crees par trempe dans le magnesium

    Energy Technology Data Exchange (ETDEWEB)

    Levy, V; Espinasse, J; Mairy, C; Hillairet, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1969-07-01

    Vacancy clustering in quenched magnesium has been studied by transmission electron microscopy. The nature of the vacancy loops observed, seems to depend essentially on the impurity content of the metal; this effect can be attributed to a variation of the stacking fault energy of magnesium due to impurities. (authors) [French] On a etudie par microscopie electronique en transmission les defauts crees par trempe dans le magnesium. Un effet considerable des impuretes du metal sur la nature des boucles obtenues par condensation de lacunes a ete mis en evidence; cet effet semble s'expliquer de facon satisfaisante par un abaissement de l'energie de faute d'empilement du magnesium du aux impuretes. (auteur)

  19. Neutrons detection by scintillation; Detection de neutrons par scintillations

    Energy Technology Data Exchange (ETDEWEB)

    Giraudon, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1955-01-15

    The absence of charge of neutrons and their elevated penetration power make difficult their detection. Techniques vary otherwise with the energy of the particle. The author proposes the realization of a scintillation detector with a big volume of liquid scintillator and containing boron for the detection of slowing-down neutrons in the domain of intermediate energies from 1 to 10{sup 5} eV about. (M.B.) [French] L'absence de charge du neutron et son pouvoir de penetration eleve rendent difficile sa detection. Les techniques par ailleurs varient avec l'energie de cette particule. L'auteur propose la realisation d'un detecteur a scintillations comprenant un grand volume de scintillateur liquide et contenant du bore pour la detection des neutrons en ralentissement dans le domaine des energies intermediaires de 1 a 10{sup 5} eV environ. (M.B.)

  20. Cancro em mogno africano no estado do Pará

    Directory of Open Access Journals (Sweden)

    Célia Regina Tremacoldi

    2013-06-01

    Full Text Available Sintomas de cancro foram observados em plantios de mogno africano, no município de Dom Eliseu, Pará. Os fungos associados aos tecidos sintomáticos foram identificados como Lasiodiplodia theobromae e Fusarium subglutinans. Culturas puras desses fungos foram testadas quanto à patogenicidade em mudas de mogno africano sadias. Apenas L. theobromae produziu cancro, por meio de inoculação por ferimento e alta umidade. A confirmação de L. theobromae como agente causal do cancro ocorreu após o reisolamento do fungo a partir das plantas inoculadas em casa de vegetação, concluindo a primeira verificação do postulado de Koch para esse patossistema.

  1. IMPROVEMENT OF PRODUCTION PLANNING IN COMPANY PARS KOMPONENTY

    Directory of Open Access Journals (Sweden)

    René Klega

    2014-03-01

    Full Text Available The article analyzes the current status of production planning in company Pars Komponenty s.r.o., proposes a new method of planning based on application of the principle of MRP. It is a discrete type of production with high complexity of BOM and MTO (Make-to-Order and ETO (Engineering-to-Order from the point of decoupling point. The original planning system plans according to production capacity backward without collisions, but for a given type of production does not work in practice. Planning system was analyzed and the main problems were identified, which were high work in progress and material stocks. This article target is to propose a new planining system based on the inclusion of time reserves of purchased material items. New planning system was tested in practise with benefit in reducing both the material inventory and work in progress.

  2. Pierre Vilar Frontinhan 1906 - París 2003

    Directory of Open Access Journals (Sweden)

    Pablo Rodríguez

    2003-01-01

    Full Text Available En el pasado mes de agosto falleció en París el historiador y maestro de tantas generaciones Pierre Vilar. Aunque había mantenido una intensa actividad de reflexión sobre los sucesos contemporáneos, ésta se vio afectada en 1991 luego que una grave enfermedad le negó la visión. Fue entonces cuando decidió con la ayuda de Rosa Congost escribir sus reflexiones y recuerdos, especie de memoria de juventud. Pensar Históricamente (Barcelona: Editorial Crítica, 1997, el libro que reúne estos ejercicios, es una obra de sumo interés para conocer la infancia, adolescencia y juventud de este connotado historiador.

  3. Neutrons detection by scintillation; Detection de neutrons par scintillations

    Energy Technology Data Exchange (ETDEWEB)

    Giraudon, J. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1955-01-15

    The absence of charge of neutrons and their elevated penetration power make difficult their detection. Techniques vary otherwise with the energy of the particle. The author proposes the realization of a scintillation detector with a big volume of liquid scintillator and containing boron for the detection of slowing-down neutrons in the domain of intermediate energies from 1 to 10{sup 5} eV about. (M.B.) [French] L'absence de charge du neutron et son pouvoir de penetration eleve rendent difficile sa detection. Les techniques par ailleurs varient avec l'energie de cette particule. L'auteur propose la realisation d'un detecteur a scintillations comprenant un grand volume de scintillateur liquide et contenant du bore pour la detection des neutrons en ralentissement dans le domaine des energies intermediaires de 1 a 10{sup 5} eV environ. (M.B.)

  4. IMAGE AND PRESS IN THE AMAZON: the configuration of the photograph in the newspaper Estado do Pará

    Directory of Open Access Journals (Sweden)

    Netilia Silva dos Anjos Seixas

    2016-12-01

    Full Text Available Este estudo busca contribuir para o entendimento da trajetória da fotografia nos jornais paraenses, a partir de um dos principais impressos do Estado, o Estado do Pará (1911-1980. Trata-se de um estudo exploratório, com base em pesquisa bibliográfica, documental e análise dos dados empíricos, usando os métodos iconográfico e iconológico, de Erwin Panofsky e Boris Kossoy. Foram observadas as fotografias publicadas em 1912, quando uma das primeiras fotografias jornalísticas foi encontrada no impresso, 1920, 1960 e 1980, nos meses de janeiro, abril, julho e outubro, correspondendo a cerca de 30 por cento do total de edições de cada ano selecionado. O jornal Estado do Pará iniciou sua edição com apresentação gráfica inovadora, destacando-se, mais tarde, com a publicação de imagens fotográficas e participando do estabelecimento da imprensa na Amazônia.   PALAVRAS-CHAVE: Fotografia de imprensa; Jornal Estado do Pará; Amazônia.     ABSTRACT This study seeks to contribute to the understanding of the trajectory of photography in the newspapers of Pará, from one of the main printed forms of the country, the State of Pará (1911-1980. It is an exploratory study, based on bibliographical research, documentary and empirical data analysis, using the iconographic and iconological methods of Erwin Panofsky and Boris Kossoy. Photographs published in 1912 were observed, when one of the first journalistic photographs was found on the press, 1920, 1960 and 1980, in the months of January, April, July and October, corresponding to about 30 percent of the total editions of each year selected. The newspaper Estado do Pará began its edition with an innovative graphic presentation, highlighting, later, with the publication of photographic images and participating in the establishment of the press in the Amazon.   KEYWORDS: Press photography; Newspaper Estado do Pará; Amazon.     RESUMEN Este estudio pretende contribuir a la comprensi

  5. Pharmaceutical Public-Private Partnerships

    DEFF Research Database (Denmark)

    Bagley, Constance; Tvarnø, Christina D.

    2014-01-01

    This article provides a game theory and law-and-management analysis of for- profit pharmaceutical public-private partnerships, a complex type of legal arrangement in the highly regulated pharmaceutical industry. A pharmaceutical public-private partnership (PPPP) agreement is a legally binding...... and a practical perspective on how properly crafted PPPP arrangements can promote innovation more efficiently than traditional self-optimizing contracts. In particular, a properly framed binding contract, coupled with respect for positive incentives, can move the parties away from an inefficient prisoners...... systems to build and share innovation. When coupled with appropriate attention to the difficult task of coordinating the actions of interdependent actors, a PPPP arrangement can enhance the likelihood of successful commercialization of pharmacological discoveries by flipping the par- ties’ incentives...

  6. Determination of tritium by counting; Dosage du tritium par comptage

    Energy Technology Data Exchange (ETDEWEB)

    Schott, R; Froment, G; Pinson, J; Genty, C [Commissariat a l' Energie Atomique, Bruyeres-le-Chatel (France). Centre d' Etudes

    1968-07-01

    Ionisation chamber assay of tritium in any gaseous mixture is a simple, fast and accurate method. We used the method of relative determination by comparison to a standard rather than the method of absolute assay in which case the constants are known with too little accuracy. The efficiency of the chamber was studied in connection to the pressure inside the chamber and its total volume. The calibration is linear in the range we are taking into account (1 to 80 millicuries). The reproducibility of the method is good: 13 runs gave a coefficient of variation of 1.6 per cent. The relative accuracy was found equal to {+-} 1.3 per cent. To end the paper, we describe in detail the apparatus and the ways of proceedings. (authors) [French] Le comptage du tritium par chambre d'ionisation est une methode simple, rapide et precise pour determiner la teneur en tritium d'un melange gazeux quelconque. Nous avons prefere utiliser la methode de determination relative par rapport a un etalon car, dans le cas d'une determination absolue, les constantes sont connues avec une trop grande incertitude. L'efficacite de la chambre a ete etudiee en fonction de la variation de la pression d'argon a l'interieur de la chambre et du volume total, de cette derniere. L'etalonnage s'est revele lineaire dans le domaine de mesures qui nous interessaient (1 a 80 millicuries). La reproductibillte de la methode est tres bonne, le coefficient de variation pour une serie de 13 essais etant de 1,6 pour cent, quant a la precision relative, elle a ete evaluee a {+-} 1,3 pour cent. Pour terminer, nous donnons une description detaillee de l'appareillage utilise et du mode operatoire suivi. (auteurs)

  7. Clinical outcomes of pars plicata anterior vitrectomy: 2-year results

    Directory of Open Access Journals (Sweden)

    Priya Narang

    2015-01-01

    Full Text Available Purpose: To demonstrate the safety and outcome of a surgical approach that uses pars plicata site for anterior vitrectomy during phacoemulsification procedure complicated by posterior capsule rupture and residual cortical matter. Design: Single center, retrospective, interventional, noncomparative study. Materials and Methods: Medical records of a consecutive series of 35 eyes of 35 patients who underwent pars plicata anterior vitrectomy (PPAV were reviewed. The main outcome measures were corrected and uncorrected distance visual acuity (CDVA, UDVA, early and late postoperative complications and intraocular pressure (IOP. Ultrasound biomicroscopic (UBM evaluation of sclerotomy site and spectral domain optical coherence tomography analysis for central macular thickness (CMT was performed. The final visual outcome at 2 years was evaluated. Results: At 2 years follow-up, the mean postoperative UDVA (logarithm of the minimum angle of resolution [logMAR] and CDVA (logMAR was 0.49 ± 0.26 and 0.19 ± 0.14, respectively. There was no significant change in the IOP (P = 0.061 and the mean CMT at 2 years was 192.5 ± 5.54 mm. The postoperative UBM image of the sclerotomy site at 8 weeks demonstrated a clear wound without any vitreous adhesion or incarceration. Intraoperative hyphema was seen in 1 (2.8% case and postoperative uveitis was seen in 2 (5.7% cases, which resolved with medications. No case of an iatrogenic retinal break or retinal detachment was reported. Conclusions: PPAV enables a closed chamber approach, allows thorough cleanup of vitreous in the pupillary plane and anterior chamber and affords better access to the subincisional and retropupillary cortical remnant with a significant visual outcome and an acceptable complication rate.

  8. Urokinase-type plasminogen activator receptor (uPAR) as a promising new imaging target

    DEFF Research Database (Denmark)

    Persson, Morten; Kjaer, Andreas

    2013-01-01

    modalities such as optical imaging, magnetic resonance imaging, single photon emission computer tomography (SPECT) and positron emission topography (PET). In this review, we will discuss recent advances in the development of uPAR-targeted imaging ligands according to imaging modality. In addition, we...... will discuss the potential future clinical application for uPAR imaging as a new imaging biomarker....

  9. Pars plana vitrectomy for disturbing primary vitreous floaters: clinical outcome and patient satisfaction

    NARCIS (Netherlands)

    Nie, K.F. de; Crama, N.; Tilanus, M.A.D.; Klevering, B.J.; Boon, C.J.F.

    2013-01-01

    BACKGROUND: Primary vitreous floaters can be highly bothersome in some patients. In the case of persistently bothersome floaters, pars plana vitrectomy may be the most effective treatment. The aim of this study is to evaluate the incidence of complications, and patient satisfaction, after pars plana

  10. Solar PAR and UVR modify the community composition and photosynthetic activity of sea ice algae.

    Science.gov (United States)

    Enberg, Sara; Piiparinen, Jonna; Majaneva, Markus; Vähätalo, Anssi V; Autio, Riitta; Rintala, Janne-Markus

    2015-10-01

    The effects of increased photosynthetically active radiation (PAR) and ultraviolet radiation (UVR) on species diversity, biomass and photosynthetic activity were studied in fast ice algal communities. The experimental set-up consisted of nine 1.44 m(2) squares with three treatments: untreated with natural snow cover (UNT), snow-free (PAR + UVR) and snow-free ice covered with a UV screen (PAR). The total algal biomass, dominated by diatoms and dinoflagellates, increased in all treatments during the experiment. However, the smaller biomass growth in the top 10-cm layer of the PAR + UVR treatment compared with the PAR treatment indicated the negative effect of UVR. Scrippsiella complex (mainly Scrippsiella hangoei, Biecheleria baltica and Gymnodinium corollarium) showed UV sensitivity in the top 5-cm layer, whereas Heterocapsa arctica ssp. frigida and green algae showed sensitivity to both PAR and UVR. The photosynthetic activity was highest in the top 5-cm layer of the PAR treatment, where the biomass of the pennate diatom Nitzschia frigida increased, indicating the UV sensitivity of this species. This study shows that UVR is one of the controlling factors of algal communities in Baltic Sea ice, and that increased availability of PAR together with UVR exclusion can cause changes in algal biomass, photosynthetic activity and community composition. © FEMS 2015. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  11. Spectral variations of UV-A and PAR solar radiation in estuarine waters of Goa

    Digital Repository Service at National Institute of Oceanography (India)

    Talaulikar, M.; Suresh, T.; Silveira, N.; Desa, E.; Matondkar, S; Lotlikar, A

    radiation (400 to 700 nm), PAR and ultraviolet radiation in the range 350-400 nm (UV-A) are presented here. The mean PAR values at the surface were 327 W/m sup(2) and reduced to 84 W/m sup(2) at first optical depth, Z sub(90) (m) in water. The first optical...

  12. The urokinase receptor (uPAR) and the uPAR-associated protein (uPARAP/Endo180)

    DEFF Research Database (Denmark)

    Behrendt, Niels

    2004-01-01

    The breakdown of the barriers formed by extracellular matrix proteins is a pre-requisite for all processes of tissue remodeling. Matrix degradation reactions take part in specific physiological events in the healthy organism but also represent a crucial step in cancer invasion. These degradation...... on the surface of various cell types that serves to bind the urokinase plasminogen activator and localize the activation reactions in the proteolytic cascade system of plasminogen activation. uPARAP is an integral membrane protein with a pronounced role in the internalization of collagen for intracellular...... degradation. Both receptors have additional functions that are currently being unraveled. The present discussion of uPAR and uPARAP is centered on their protein structure and molecular and cellular function....

  13. Effect of simvastatin and ezetimibe on suPAR levels and outcomes

    DEFF Research Database (Denmark)

    Hodges, Gethin W; Bang, Casper N; Forman, Julie L

    2018-01-01

    -lowering therapy also lowers suPAR levels is unknown. METHODS: We investigated whether treatment with Simvastatin 40 mg and Ezetimibe 10 mg lowered plasma suPAR levels in 1838 patients with mild-moderate, asymptomatic aortic stenosis, included in the Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) study, using...... and Ezetimibe treatment impeded the progression of the time-related increase in plasma suPAR levels. Year-1 suPAR was associated with all-cause mortality, MCE, and AVE irrespective of baseline levels (SEAS study: NCT00092677)....... cardiovascular events (MCE) composed of ischemic cardiovascular events (ICE) and aortic valve related events (AVE). RESULTS: After 4.3 years of follow-up, suPAR levels had increased by 9.2% (95% confidence interval [CI]: 7.0%-11.5%) in the placebo group, but only by 4.1% (1.9%-6.2%) in the group with lipid...

  14. Brulure par Plaque de Bistouri Electrique: a Propos de Quatre Cas

    Science.gov (United States)

    Khales, A.; Achbouk, A.; Belmir, R.; Cherkab, L.; Ennouhi, M.A.; Ababou, K.; Ihrai, H.

    2010-01-01

    Summary La brûlure par plaque de bistouri électrique est un accident rare mais grave par la profondeur de la lésion et par sa localisation, surtout quand qu’elle survient dans un contexte chirurgical dont le vécu reste difficile de la part du malade et du chirurgien. Cette brûlure bien que imprévisible reste grave par la profondeur et la localisation de la brûlure et par sa survenue dans un contexte opératoire, chez des patients malades. La prise en charge de la brûlure doit se faire en milieu spécialisé. La prévention reste le seul moyen d’éviter ce type d’accident. PMID:21991216

  15. par genes in Mycobacterium bovis and Mycobacterium smegmatis are arranged in an operon transcribed from "SigGC" promoters

    Directory of Open Access Journals (Sweden)

    Casart Yveth

    2008-03-01

    Full Text Available Abstract Background The ParA/Soj and ParB/Spo0J proteins, and the cis-acting parS site, participate actively in chromosome segregation and cell cycle progression. Genes homologous to parA and parB, and two putative parS copies, have been identified in the Mycobacterium bovis BCG and Mycobacterium smegmatis chromosomes. As in Mycobacterium tuberculosis, the parA and parB genes in these two non-pathogenic mycobacteria are located near the chromosomal origin of replication. The present work focused on the determination of the transcriptional organisation of the ~6 Kb orf60K-parB region of M. bovis BCG and M. smegmatis by primer extension, transcriptional fusions to the green fluorescence protein (GFP and quantitative RT-PCR. Results The parAB genes were arranged in an operon. However, we also found promoters upstream of each one of these genes. Seven putative promoter sequences were identified in the orf60K-parB region of M. bovis BCG, whilst four were identified in the homologous region of M. smegmatis, one upstream of each open reading frame (ORF. Real-time PCR assays showed that in M. smegmatis, mRNA-parA and mRNA-parB levels decreased between the exponential and stationary phases. In M. bovis BCG, mRNA-parA levels also decreased between the exponential and stationary phases. However, parB expression was higher than parA expression and remained almost unchanged along the growth curve. Conclusion The majority of the proposed promoter regions had features characteristic of Mycobacterium promoters previously denoted as Group D. The -10 hexamer of a strong E. coli σ70-like promoter, located upstream of gidB of M. bovis BCG, overlapped with a putative parS sequence, suggesting that the transcription from this promoter might be regulated by the binding of ParB to parS.

  16. MODIS-derived daily PAR simulation from cloud-free images and its validation

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Liangfu; Gu, Xingfa; Tian, Guoliang [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China); The Center for National Spaceborne Demonstration, Beijing 100101 (China); Gao, Yanhua [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China); Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101 (China); Yang, Lei [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China); Jilin University, Changchun 130026 (China); Liu, Qinhuo [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China)

    2008-06-15

    In this paper, a MODIS-derived daily PAR (photosynthetically active radiation) simulation model from cloud-free image over land surface has been developed based on Bird and Riordan's model. In this model, the total downwelling spectral surface irradiance is divided into two parts: one is beam irradiance, and another is diffuse irradiance. The attenuation of solar beam irradiance comprises scattering by the gas mixture, absorption by ozone, the gas mixture and water vapor, and scattering and absorption by aerosols. The diffuse irradiance is scattered out of the direct beam and towards the surface. The multiple ground-air interactions have been taken into account in the diffuse irradiance model. The parameters needed in this model are atmospheric water vapor content, aerosol optical thickness and spectral albedo ranging from 400 nm to 700 nm. They are all retrieved from MODIS data. Then, the instantaneous photosynthetically available radiation (IPAR) is integrated by using a weighted sum at each of the visible MODIS wavebands. Finally, a daily PAR is derived by integration of IPAR. In order to validate the MODIS-derived PAR model, we compared the field PAR measurements in 2003 and 2004 against the simulated PAR. The measurements were made at the Qianyanzhou ecological experimental station, Chinese Ecosystem Research Network. A total of 54 days of cloud-free MODIS L1B level images were used for the PAR simulation. Our results show that the simulated PAR is consistent with field measurements, where the correlation coefficient of linear regression between calculated PAR and measured PAR is 0.93396. However, there were some uncertainties in the comparison of 1 km pixel PAR with the tower flux stand measurement. (author)

  17. Quantitative Methods in Public Administration: their use and development through time

    NARCIS (Netherlands)

    Groeneveld, S.M.; Tummers, L.G.; Bronkhorst, B.A.C.; Ashikali, T.S.; van Thiel, S.

    2015-01-01

    This article aims to contribute to recent debates on research methods in public administration by examining the use of quantitative methods in public administration research. We analyzed 1,605 articles published between 2001-2010 in four leading journals: JPART, PAR, Governance and PA. Results show

  18. Public Schools

    Data.gov (United States)

    Department of Homeland Security — This Public Schools feature dataset is composed of all Public elementary and secondary education in the United States as defined by the Common Core of Data, National...

  19. Urine suPAR levels compared with plasma suPAR levels as predictors of post-consultation mortality risk among individuals assumed to be TB-negative: a prospective cohort study

    DEFF Research Database (Denmark)

    Rabna, Paulo; Andersen, Andreas; Wejse, Christian

    2010-01-01

    -suPAR was measured using a commercial ELISA (suPARnostic®). We found that U-suPAR carried significant prognostic information on mortality for HIV-infected subjects with an area under the ROC curve of 0.75. For HIV-negative individuals, little or no prognostic effect was observed. However, in both HIV positives...... and negatives, the predictive effect of U-suPAR was found to be inferior to that of P-suPAR....

  20. Rabies Virus in Bats, State of Pará, Brazil, 2005-2011.

    Science.gov (United States)

    Pereira, Armando de Souza; Casseb, Livia Medeiros Neves; Barbosa, Taciana Fernandes Souza; Begot, Alberto Lopes; Brito, Roberto Messias Oliveira; Vasconcelos, Pedro Fernando da Costa; Travassos da Rosa, Elizabeth Salbé

    2017-08-01

    Rabies is an acute, progressive zoonotic viral infection that in general produces a fatal outcome. This disease is responsible for deaths in humans and animals worldwide and, because it can affect all mammals, is considered one of the most important viral infections for public health. This study aimed to determine the prevalence of rabies in bats of different species found in municipalities of the state of Pará from 2005 to 2011. The rabies virus was detected in 12 (0.39%) bats in a total of 3100 analyzed, including hematophagous, frugivorous, and insectivorous bats. Of these, eleven were characterized as AgV3, which is characteristic of the hematophagous bat Desmodus rotundus (E. Geoffroy 1810); one insectivorous animal showed a different profile compatible with the Eptesicus pattern and may therefore be a new antigenic variant. This study identified the need for greater intensification of epidemiological surveillance in municipalities lacking rabies surveillance (silent areas); studies of rabies virus in bats with different alimentary habits, studies investigating the prevalence of AgV3, and prophylactic measures in areas where humans may be infected are also needed.

  1. Antimicrobial Resistance of Shigella spp. isolated in the State of Pará, Brazil

    Directory of Open Access Journals (Sweden)

    Flávia Corrêa Bastos

    2011-10-01

    Full Text Available INTRODUCTION: Shigella spp. are Gram-negative, nonsporulating, rod-shaped bacteria that belong to the family Enterobacteriaceae and are responsible for shigellosis or bacillary dysentery, an important cause of worldwide morbidity and mortality. METHODS: We studied the antibiotic resistance profiles of 122 Shigella spp. strains (81 S. flexneri, 41 S. sonnei, 1 S. boydii isolated from patients (female and male from 0 to 80 years of age presenting diarrhea in different districts of the State of Pará, in the North of Brazil. The antibiotic resistance of the strains, isolated from human fecal samples, was determined by the diffusion disk method and by using the VITEK-2 system. RESULTS: The highest resistance rate found was the resistance rate to tetracycline (93.8%, followed by the resistance rate to chloramphenicol (63.9% and to trimethoprim/sulfamethoxazole (63.1%. Resistance to at least three drugs was more common among S. flexneri than S. sonnei (39.5% vs. 10%. Six (4.9% strains were susceptible to all the antibiotics tested. All strains were susceptible to cefotaxime, ceftazidime, ciprofloxacin, nalidixic acid and nitrofurantoin. CONCLUSIONS: High rates of multidrug resistance in Shigella spp. are a serious public health concern in Brazil. It is extremely important to continuously monitor the antimicrobial resistances of Shigella spp. for effective therapy and control measures against shigellosis.

  2. Disposal of Low-Activity Liquid Effluents by Dilution; Elimination par Dilution d'Effluents Liquides Faiblement Radioactifs; 0423 0414 0410 041b 0414 ; Eliminacion de Efluentes Liquidos de Baja Radiactividad por Dilucion

    Energy Technology Data Exchange (ETDEWEB)

    Bovard, P.; Candillon, C. [Service de Controle des Radiations et de Genie Radioactif, Commissariat a l' Energie Atomique, Saclay (France)

    1960-07-01

    From the results already obtained in France by monitoring radioactivity in the neighbourhood of nuclear plant, some conclusions may be drawn regarding the choice of disposal procedures. I. Results obtained In 1957 we started a progressive study of the effect exerted by nuclear plant. In order to establish the proportion due to the nuclear centres, the study comprises determination of the levels of natural radioactivity and artificial contamination. Examples related to reference areas are quoted. The greater part of artificial radioactivity is apparently due to radioactive fall-out; this is not surprising, considering the quantities of radioactive isotopes disposed of in France to date. Some laboratory tests have been made. These have helped to determine certain mechanisms, have increased our knowledge of site pollution, and have enabled us to improve our sampling methods. II. Laboratory tests These were concerned with 1. adsorption phenomena similar to those occurring in rivers and streams in the course of effluent dilution: fixation on finely-divided minerals, e.g. mica and quartz. Radioisotopes such as Sr{sup 9}'0, Cs{sup 137} and Y{sup 90} appear to behave very differently: under average disposal conditions Sr{sup 90} seems to be the least adsorbed; 2. soil and plant contamination, utilizing columns and cubes of soil in situ. We found it necessary to standardize our samples so as to facilitate further analysis and make the results comparable. III. Site selection and ways and means of disposal From this group of still incomplete results and studies we are attempting to educe certain principles to govern site selection. Once the site has been chosen, the experience gained enables natural conditions to be turned to account. (author) [French] Des resultats deja fournis par la surveillance en France, de la radioactivite aux alentours des installations nucleaires, il est possible de tirer certains enseignements quant au choix des processus de rejet. I. Resultats

  3. Public acceptability

    International Nuclear Information System (INIS)

    Bolter, H.E.

    1989-01-01

    An urgent need to rebuild public confidence after an incident attracting widespread adverse publicity led to the development by British Nuclear Fuels plc of a completely new approach to public relations. The Company's experience suggests that impressions count more than sheer information, provided the impressions have a firm base in reality. (author)

  4. Soroprevalência de infecções por vírus da hepatite B e vírus da hepatite C em indivíduos do Estado do Pará Seroprevalence of hepatitis B virus and hepatitis C virus infections among individuals in the State of Pará

    Directory of Open Access Journals (Sweden)

    José Américo Aquino

    2008-08-01

    Full Text Available As hepatites B e C continuam sendo um importante problema de saúde pública no Brasil. Neste estudo, determinou-se a prevalência de marcadores sorológicos para as hepatites B e C em indivíduos do Estado do Pará, atendidos no Laboratório Central de Saúde Pública do Pará, no período de janeiro de 2002 a dezembro de 2005. Foram realizados 11.282 exames para a pesquisa do HBsAg, 2.342 para o anti-HBc e 5.542 para o anti-vírus da hepatite C. A prevalência de HBsAg foi de 3,6% e predominou na faixa etária de 20 a 29 anos, enquanto que o anti-HBc foi observado em 37,7% dos indivíduos. A prevalência do antivírus da hepatite C foi de 3,6% e predominou entre indivíduos acima de 50 anos. Assim, as freqüências dos marcadores encontradas no Pará foram mais altas que em vários outros estados do país, sugerindo a necessidade de medidas de saúde publica mais eficazes no combate a estes agravos na região.Hepatitis B and C continue to be important public health problems in Brazil. In this study, the prevalence of serological markers for hepatitis B and C in individuals from the State of Pará, attended at the Central Public Health Laboratory of Pará between January 2002 and December 2005, was determined. 11,282 tests to investigate HBsAg, 2,342 for anti-HBc and 5,542 for anti-HCV were performed. The prevalence of HBsAg was 3.6% and it was predominantly found in the age range of 20 to 29 years old, while anti-HBC was observed in 37.7% of the subjects. The prevalence of anti-hepatitis C virus was 3.6% and it was predominantly found in individuals over 50 years old. Thus, the frequencies of the markers found in Pará were higher than many other states in Brazil, hence suggesting that there is a need for public health measures of greater effectiveness for combating these illnesses in this region.

  5. Proteinase-Activated Receptor-1 and Immunomodulatory Effects of a PAR1-Activating Peptide in a Mouse Model of Prostatitis

    Science.gov (United States)

    Stanton, M. Mark; Nelson, Lisa K.; Benediktsson, Hallgrimur; Hollenberg, Morley D.; Buret, Andre G.; Ceri, Howard

    2013-01-01

    Background. Nonbacterial prostatitis has no established etiology. We hypothesized that proteinase-activated receptor-1 (PAR1) can play a role in prostatitis. We therefore investigated the effects of PAR1 stimulation in the context of a new model of murine nonbacterial prostatitis. Methods. Using a hapten (ethanol-dinitrobenzene sulfonic acid- (DNBS-)) induced prostatitis model with both wild-type and PAR1-null mice, we examined (1) the location of PAR1 in the mouse prostate and (2) the impact of a PAR1-activating peptide (TFLLR-NH2: PAR1-TF) on ethanol-DNBS-induced inflammation. Results. Ethanol-DNBS-induced inflammation was maximal at 2 days. In the tissue, PAR1 was expressed predominantly along the apical acini of prostatic epithelium. Although PAR1-TF on its own did not cause inflammation, its coadministration with ethanol-DNBS reduced all indices of acute prostatitis. Further, PAR1-TF administration doubled the prostatic production of interleukin-10 (IL-10) compared with ethanol-DNBS treatment alone. This enhanced IL-10 was not observed in PAR1-null mice and was not caused by the reverse-sequence receptor-inactive peptide, RLLFT-NH2. Surprisingly, PAR1-TF, also diminished ethanol-DNBS-induced inflammation in PAR1-null mice. Conclusions. PAR1 is expressed in the mouse prostate and its activation by PAR1-TF elicits immunomodulatory effects during ethanol-DNBS-induced prostatitis. However, PAR1-TF also diminishes ethanol-DNBS-induced inflammation via a non-PAR1 mechanism by activating an as-yet unknown receptor. PMID:24459330

  6. Profiling gene expression induced by protease-activated receptor 2 (PAR2 activation in human kidney cells.

    Directory of Open Access Journals (Sweden)

    Jacky Y Suen

    Full Text Available Protease-Activated Receptor-2 (PAR2 has been implicated through genetic knockout mice with cytokine regulation and arthritis development. Many studies have associated PAR2 with inflammatory conditions (arthritis, airways inflammation, IBD and key events in tumor progression (angiogenesis, metastasis, but they have relied heavily on the use of single agonists to identify physiological roles for PAR2. However such probes are now known not to be highly selective for PAR2, and thus precisely what PAR2 does and what mechanisms of downstream regulation are truly affected remain obscure. Effects of PAR2 activation on gene expression in Human Embryonic Kidney cells (HEK293, a commonly studied cell line in PAR2 research, were investigated here by comparing 19,000 human genes for intersecting up- or down-regulation by both trypsin (an endogenous protease that activates PAR2 and a PAR2 activating hexapeptide (2f-LIGRLO-NH(2. Among 2,500 human genes regulated similarly by both agonists, there were clear associations between PAR2 activation and cellular metabolism (1,000 genes, the cell cycle, the MAPK pathway, HDAC and sirtuin enzymes, inflammatory cytokines, and anti-complement function. PAR-2 activation up-regulated four genes more than 5 fold (DUSP6, WWOX, AREG, SERPINB2 and down-regulated another six genes more than 3 fold (TXNIP, RARG, ITGB4, CTSD, MSC and TM4SF15. Both PAR2 and PAR1 activation resulted in up-regulated expression of several genes (CD44, FOSL1, TNFRSF12A, RAB3A, COPEB, CORO1C, THBS1, SDC4 known to be important in cancer. This is the first widespread profiling of specific activation of PAR2 and provides a valuable platform for better understanding key mechanistic roles of PAR2 in human physiology. Results clearly support the development of both antagonists and agonists of human PAR2 as potential disease modifying therapeutic agents.

  7. Comparaison du Pangola (Digitaria decumbens) et du Stargrass (Cynodon nlemfluensis) exploités par des ovins

    OpenAIRE

    Boval, Maryline

    1989-01-01

    A la Martinique l'utilisation comparée de Digitaria decumbens (Dd) et de Cynodon nlemfuensis (Cn) par des brebis allaitantes a été étudiée pendant une période d'observation de 6 mois. Le cheptel est à un taux élevé de 1 600 kg de poids vif par hectare et par an, obtenu par une fertilisation de 450 kg/ha/an en azote.

  8. Participatory action as a research method with public health nurses.

    Science.gov (United States)

    Cusack, Cheryl; Cohen, Benita; Mignone, Javier; Chartier, Mariette J; Lutfiyya, Zana

    2018-02-28

    This article explores and describes participatory action research (PAR) as a preferred method in addressing nursing practice issues. This is the first study that used PAR with public health nurses (PHNs) in Canada to develop a professional practice model. Participatory action research is a sub-category of action research that incorporates feminist and critical theory with foundations in the field of social psychology. For nurses, critical analysis of long-established beliefs and practices through PAR contributes to emancipatory knowledge regarding the impact of traditional hierarchies on their practice. This study used participatory action, a non-traditional but systematic research method, which assisted participants to develop a solution to a long-standing organizational issue. The stages of generating concerns, participatory action, acting on concerns, reflection and evaluation were implemented from 2012 - 2013 in an urban Canadian city, to develop a professional practice model for PHNs. Four sub-themes specific to PAR are discussed. These are "participatory action research engaged PHNs in development of a professional practice model;" "the participatory action research cycles of "Look, Think, Act" expanded participants' views;" "participatory action research increased awareness of organizational barriers;" and "participatory action research promoted individual empowerment and system transformation." This study resulted in individual and system change that may not have been possible without the use of PAR. The focus was engagement of participants and recognition of their lived experience, which facilitated PHNs' empowerment, leadership and consciousness-raising. © 2018 The Authors. Journal of Advanced Nursing Published by John Wiley & Sons Ltd.

  9. Epuration des eaux usées de raffinerie par le procédé biologique des lits bactériens. Problèmes pratiques de l'exploitation Purifying Refinery Waste Water by the Bacterial Bed Biological Process. Practical Operational Problems

    Directory of Open Access Journals (Sweden)

    Leising M.

    2006-11-01

    Full Text Available Le traitement des eaux de raffinerie par le procédé des Iits bactériens constitue une solution intéressante. Néanmoins, il subsiste actuellement des problèmes pratiques d'exploitation, en particulier la tendance au colmatage des lits bactériens existants qui résulte d'un encrassement incontrôlé des garnissages en vrac. Après étude, il est confirmé que les hydrocarbures, les matières en suspension contenus dans l'effluent et une mauvaise évacuation de la biomasse sont à l'origine du problème. L'examen des possibilités de lutte contre ce phénomène permet de distinguer des mesures curatives et des mesure préventives. Les mesures curatives qui consistent à régénérer le garnissage par augmentation de la charge hydraulique, nettoyage chimique, ou nettoyage manuel ne donnent pas entière satisfaction. Parmi tes mesures préventives, l'une des méthodes consiset à réduire la charge polluante de l'effluent : les eaux usées phénolées sont dessalées, les eaux de désulfuration du gas oil (DGO et fluid cracking catalytic (FCC sont strippées, les soudes sont réinjectées dans le brut, les huiles récupérées juste en aval de leur rejet, les traitements primaires sont optimisés, notamment par installation de racleurs et de tambours oléophiles sur les séparateurs API et par un meilleur choix de floculants. Néanmoins, l'expérience montre que cette méthode ne permet que de retarder l'échéance du colmatage. Le meilleur moyen de lutte réside dans le choix du matériau de garnissage, ainsi que le montrent les essais pilotes comparatifs réalisés par l'Institut National de Recherche Chimique Appliquée (lRCHA et Compagnie Française de Raffinage (CFR. Ces essais, qui ont portés sur l'évolution de la densité du garnissage, les performances épuratoires et la qualité des boues montrent que le Cloisonyle, garnissage tubulaire, est probablement le matériau le mieux adapté. Refinery waste-water treatment by trickling

  10. Improved Satellite-based Photosysnthetically Active Radiation (PAR) for Air Quality Studies

    Science.gov (United States)

    Pour Biazar, A.; McNider, R. T.; Cohan, D. S.; White, A.; Zhang, R.; Dornblaser, B.; Doty, K.; Wu, Y.; Estes, M. J.

    2015-12-01

    One of the challenges in understanding the air quality over forested regions has been the uncertainties in estimating the biogenic hydrocarbon emissions. Biogenic volatile organic compounds, BVOCs, play a critical role in atmospheric chemistry, particularly in ozone and particulate matter (PM) formation. In southeastern United States, BVOCs (mostly as isoprene) are the dominant summertime source of reactive hydrocarbon. Despite significant efforts in improving BVOC estimates, the errors in emission inventories remain a concern. Since BVOC emissions are particularly sensitive to the available photosynthetically active radiation (PAR), model errors in PAR result in large errors in emission estimates. Thus, utilization of satellite observations to estimate PAR can help in reducing emission uncertainties. Satellite-based PAR estimates rely on the technique used to derive insolation from satellite visible brightness measurements. In this study we evaluate several insolation products against surface pyranometer observations and offer a bias correction to generate a more accurate PAR product. The improved PAR product is then used in biogenic emission estimates. The improved biogenic emission estimates are compared to the emission inventories over Texas and used in air quality simulation over the period of August-September 2013 (NASA's Discover-AQ field campaign). A series of sensitivity simulations will be performed and evaluated against Discover-AQ observations to test the impact of satellite-derived PAR on air quality simulations.

  11. Pars plana Ahmed valve and vitrectomy in patients with glaucoma associated with posterior segment disease.

    Science.gov (United States)

    Wallsh, Josh O; Gallemore, Ron P; Taban, Mehran; Hu, Charles; Sharareh, Behnam

    2013-01-01

    To assess the safety and efficacy of a modified technique for pars plana placement of the Ahmed valve in combination with pars plana vitrectomy in the treatment of glaucoma associated with posterior segment disease. Thirty-nine eyes with glaucoma associated with posterior segment disease underwent pars plana vitrectomy combined with Ahmed valve placement. All valves were placed in the pars plana using a modified technique, without the pars plana clip, and using a scleral patch graft. The 24 eyes diagnosed with neovascular glaucoma had an improvement in intraocular pressure from 37.6 mmHg to 13.8 mmHg and best-corrected visual acuity from 2.13 logarithm of minimum angle of resolution to 1.40 logarithm of minimum angle of resolution. Fifteen eyes diagnosed with steroid-induced glaucoma had an improvement in intraocular pressure from 27.9 mmHg to 14.1 mmHg and best-corrected visual acuity from 1.38 logarithm of minimum angle of resolution to 1.13 logarithm of minimum angle of resolution. Complications included four cases of cystic bleb formation and one case of choroidal detachment and explantation for hypotony. Ahmed valve placement through the pars plana during vitrectomy is an effective option for managing complex cases of glaucoma without the use of the pars plana clip.

  12. Effects of solar PAR and UV radiation on tropical biofouling communities

    KAUST Repository

    Dobretsov, SV

    2010-03-08

    We investigated the effect of solar ultraviolet radiation (UVR) and photosynthetically active radiation (PAR) on the development of tropical micro- and macrofouling communities for 30 d. The experimental design involved 3 treatments: full spectrum (PAR+UVR), PAR only, and minimal light (reduced PAR and UVR). Terminal restriction fragment length polymorphism analysis demonstrated that different light conditions resulted in the formation of highly different microbial communities. The lowest densities of bacteria were found under the full spectrum treatment, while the lowest densities of diatoms were found in the minimal light treatment. Macrofouling communities consisted of 13 species and differed among light treatments. In the presence of UVR, communities had low species diversity, evenness, and richness, while in minimal light and PAR treatments, communities had high species diversity, evenness, and richness. Similarity percentage (SIMPER) analysis revealed that the tubeworm Hydroides elegans, the alga Ulva (Enteromorpha) sp., and the bivalve Perna viridis were the species responsible for most of the dissimilarities in macrofouling communities among treatments. While densities of H. elegans were similar in the PAR and minimal light treatments, this polychaete had higher growth rates under minimal light conditions. We conclude that UVR and PAR directly control the development of shallow micro- and macrofouling communities by inhibiting the recruitment and growth of sensitive species and promoting the growth of resistant species, but also that these forms of solar radiation influence the surface cues available to competent larvae by altering the development of the microbial community.

  13. The pars intermedia: an anatomic basis for a coordinated vascular response to female genital arousal.

    Science.gov (United States)

    Shih, Cheryl; Cold, Christopher J; Yang, Claire C

    2013-06-01

    The pars intermedia is an area of the vulva that has been inconsistently described in the literature. We conducted anatomic studies to better describe the tissues and vascular structures of the pars intermedia and proposed a functional rationale of the pars intermedia in the female sexual response. Nine cadaveric vulvectomy specimens were used. Each was serially sectioned and stained with hematoxylin and eosin and Masson's trichrome. Histologic ultrastructural description of the pars intermedia. The pars intermedia contains veins traveling longitudinally in the angle of the clitoris, supported by collagen-rich stromal tissues. These veins drain the different vascular compartments of the vulva, including the clitoris, the bulbs, and labia minora; also, the interconnecting veins link the different vascular compartments. The pars intermedia is not composed of erectile tissue, distinguishing it from the erectile tissues of the corpora cavernosa of the clitoris as well as the corpus spongiosum of the clitoral (vestibular) bulbs. The venous communications of the pars intermedia, linking the erectile tissues with the other vascular compartments of the vulva, appear to provide the anatomic basis for a coordinated vascular response during female sexual arousal. © 2012 International Society for Sexual Medicine.

  14. Hunger amidst plenty along the coast of Pará

    Directory of Open Access Journals (Sweden)

    Ivete Nascimento

    2006-08-01

    Full Text Available In this work one analyzes some referring questions to the new significações of the temporality constructed socially enters the artisan fishing of the coast, in the city of Maracanã, using as boundary-maker the concepts the concepts of abundance and famitura the one that they send themselves to the speech in way of life of the past and the gift. It will see as the typical way of life of the rescued past of the memory of old and the meaning of the abundance in the time of the fishing-farmer, the counterpoint with the concept of famitura of the fishing-exclusive of the gift, where the loss surpasses the scope of the strict survival reaching the proper way of life with the weakness of solidarity. This analysis will be given mecanicamente in the conceptual field of the time measured for the tasks and of the time chronometered for the clock. The intensive field work ocurred on Fortaleza of the Mocooca community incorporating data gotten a long the author's experience in the fish artisan thematic of the Pará coast.

  15. Le Web pour enseigner par projets et favoriser la collaboration

    Directory of Open Access Journals (Sweden)

    Sylvie Ratté

    2004-01-01

    Full Text Available L’utilisation du Web présentée dans cet article vient appuyer une démarche pédagogique fondée sur le partage des savoirs. Dans le contexte d’une simulation industrielle, les étudiants d’un cours de programmation avancée doivent apprendre à partager leur expertise, à communiquer clairement leurs questions, à décrire des problèmes et à faire face à des retournements inattendus. Le Web devient un espace de collaboration pour diffuser les requêtes d’un client fictif, les directives, les travaux préliminaires et les ententes. Les résultats obtenus tendent à suggérer que cette approche globale force l’étudiant à mieux planifier, l’invite à mieux formuler et décrire les problèmes, augmente le niveau de collaboration et facilite la production d’analogies. Un système facilitant la logistique entourant la revue par les pairs (récupération des travaux, construction d’une grille d’évaluation et diffusion des résultats est également présenté.

  16. Design of 118 MHz twelfth harmonic cavity of APS PAR

    International Nuclear Information System (INIS)

    Kang, Y.W.; Kustom, R.L.; Bridges, J.F.

    1992-01-01

    Two radio frequency (RF) cavities are needed in the Positron Accumulator Ring (PAR) of the Advanced Photon Source. One is for the first harmonic frequency at 9.8 MHz, and the other is for the twelfth harmonic frequency at 118 MHz. This note reports on the design of the 118 MHz RF cavity. Computer models are used to find the mode frequencies, impedances, Q-factors, and field distributions in the cavity. The computer codes MAFIA, URMEL, and URMEL-T are useful tools which model and simulate the resonance characteristics of a cavity. These codes employ the finite difference method to solve Maxwell's equations. MAFIA is a three-dimensional problem solver and uses square patches to approximate the inner surface of a cavity. URMEL and URMEL-T are two-dimensional problem solvers and use rectangular and triangular meshes, respectively. URMEL-T and MAFIA can handle problems with arbitrary dielectric materials located inside the boundary. The cavity employs a circularly cylindrical ceramic window to limit the vacuum to the beam pipe. The ceramic window used in the modeling will have a wall thickness of 0.9 cm. This wall thickness is not negligible in determining the resonant frequencies of the cavity. In the following, results of two- and three-dimensional modeling of the cavities using the URMEL-T and MAFIA codes are reported

  17. Characterization of ParTI Phoswiches Using Charged Pion Beams

    Science.gov (United States)

    Churchman, Emily; Zarrella, Andrew; Youngs, Michael; Yennello, Sherry

    2017-09-01

    The Partial Truncated Icosahedron (ParTI) detector array consists of 15 phoswiches. Each phoswich is made of two scintillating components - a thallium-doped cesium iodide (CsI(Tl)) crystal and an EJ-212 scintillating plastic - coupled to a photomultiplier tube. Both materials have different scintillation times and are sensitive to both charged and neutral particles. The type of particle and amount of energy deposited determine the shape of the scintillation pulse as a function of time. By integrating the fast and slow signals of the scintillation pulses, a ``Fast vs. Slow Integration'' plot can be created that produces particle identification lines based on the energy deposited in the scintillating materials. Four of these phoswiches were taken to the Paul Scherrer Institute (PSI) in Switzerland where π + , π-, and proton beams were scattered onto the phoswiches to demonstrate their particle identification (PID) capabilities. Using digitizers to record the detector response waveforms, pions can also be identified by the characteristic decay pulse of the muon daughters.

  18. Monitoreo de parásitos en efluentes domiciliarios

    Directory of Open Access Journals (Sweden)

    Semenas Liliana

    1999-01-01

    Full Text Available OBJETIVO: Evaluar la presencia de parásitos en efluentes semisólidos y líquidos en distintas localidades de la Patagonia argentina considerando que ésta es una de las restricciones para su uso. MÉTODOS: Las muestras tomadas en 4 Plantas de Tratamiento de Efluentes Domiciliarios se analizaron siguiendo las normativas de Environmental Protection Agency, Organización Mundial de la Salud, Standard Methods for Examination of Water and Wastewater y de algunas clasificaciones. RESULTADOS: Solamente 2 de las 6 muestras de semisólidos analizadas tenían huevos de Ascaris lumbricoides no viables. De las 10 muestras líquidas, solamente 2 no tenían huevos mientras las restantes tenían patógenos de las categorías I (Giardia sp., Hymenolepis diminuta y Enterobius vermicularis y III (Ascaris lumbricoides, Ancylostoma duodenale y Trichuris trichiura. CONCLUSIONES: Todas las muestras de semisólidos analizadas fueron aptas para su uso como fertilizantes porque no se registró en ninguna de ellas la presencia de huevos viables de Ascaris lumbricoides y solamente 6 de las muestras líquidas fueron aptas para riego por carecer de huevos o por ser su concentración igual o inferior a 1 huevo por litro.

  19. MMP-1/PAR-1 signal transduction axis and its prognostic impact in esophageal squamous cell carcinoma

    Directory of Open Access Journals (Sweden)

    Hong-hua Peng

    2012-01-01

    Full Text Available The matrix metalloprotease-1 (MMP-1/protease-activated receptor-1 (PAR-1 signal transduction axis plays an important role in tumorigenesis. To explore the expression and prognostic value of MMP-1 and PAR-1 in esophageal squamous cell carcinoma (ESCC, we evaluated the expression of two proteins in resected specimens from 85 patients with ESCC by immunohistochemistry. Sixty-two (72.9% and 58 (68.2% tumors were MMP-1- and PAR-1-positive, respectively, while no significant staining was observed in normal esophageal squamous epithelium. MMP-1 and PAR-1 overexpression was significantly associated with tumor node metastasis (TNM stage and regional lymph node involvement. Patients with MMP-1- and PAR-1-positive tumors, respectively, had poorer disease-free survival (DFS than those with negative ESCC (P = 0.002 and 0.003, respectively. Univariate analysis showed a significant relationship between TNM stage [hazard ratio (HR = 2.836, 95% confidence interval (CI = 1.866-4.308], regional lymph node involvement (HR = 2.955, 95%CI = 1.713-5.068, MMP-1 expression (HR = 2.669, 95%CI = 1.229-6.127, and PAR-1 expression (HR = 1.762, 95%CI = 1.156-2.883 and DFS. Multivariate analysis including the above four parameters identified TNM stage (HR = 2.035, 95%CI = 1.167-3.681, MMP-1 expression (HR = 2.109, 95%CI = 1.293-3.279, and PAR-1 expression (HR = 1.967, 95%CI = 1.256-2.881 as independent and significant prognostic factors for DFS. Our data suggest for the first time that MMP-1 and PAR-1 were both overexpressed in ESCC and are novel predictors of poor patient prognosis after curative resection. The MMP-1/PAR-1 signal transduction axis might be a new therapeutic target for future therapies tailored against ESCC.

  20. MMP-1/PAR-1 signal transduction axis and its prognostic impact in esophageal squamous cell carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Peng, Hong-hua; Zhang, Xi; Cao, Pei-guo [Department of Oncology, the Third Xiangya Hospital, Central South University, Changsha, Hunan Province (China)

    2011-11-18

    The matrix metalloprotease-1 (MMP-1)/protease-activated receptor-1 (PAR-1) signal transduction axis plays an important role in tumorigenesis. To explore the expression and prognostic value of MMP-1 and PAR-1 in esophageal squamous cell carcinoma (ESCC), we evaluated the expression of two proteins in resected specimens from 85 patients with ESCC by immunohistochemistry. Sixty-two (72.9%) and 58 (68.2%) tumors were MMP-1- and PAR-1-positive, respectively, while no significant staining was observed in normal esophageal squamous epithelium. MMP-1 and PAR-1 overexpression was significantly associated with tumor node metastasis (TNM) stage and regional lymph node involvement. Patients with MMP-1- and PAR-1-positive tumors, respectively, had poorer disease-free survival (DFS) than those with negative ESCC (P = 0.002 and 0.003, respectively). Univariate analysis showed a significant relationship between TNM stage [hazard ratio (HR) = 2.836, 95% confidence interval (CI) = 1.866-4.308], regional lymph node involvement (HR = 2.955, 95%CI = 1.713-5.068), MMP-1 expression (HR = 2.669, 95%CI = 1.229-6.127), and PAR-1 expression (HR = 1.762, 95%CI = 1.156-2.883) and DFS. Multivariate analysis including the above four parameters identified TNM stage (HR = 2.035, 95%CI = 1.167-3.681), MMP-1 expression (HR = 2.109, 95%CI = 1.293-3.279), and PAR-1 expression (HR = 1.967, 95%CI = 1.256-2.881) as independent and significant prognostic factors for DFS. Our data suggest for the first time that MMP-1 and PAR-1 were both overexpressed in ESCC and are novel predictors of poor patient prognosis after curative resection. The MMP-1/PAR-1 signal transduction axis might be a new therapeutic target for future therapies tailored against ESCC.

  1. Antimicrobial Resistance of Shigella spp. isolated in the State of Pará, Brazil Resistência Antimicrobiana de Shigella spp. isoladas no Estado do Pará

    Directory of Open Access Journals (Sweden)

    Flávia Corrêa Bastos

    2011-10-01

    Full Text Available INTRODUCTION: Shigella spp. are Gram-negative, nonsporulating, rod-shaped bacteria that belong to the family Enterobacteriaceae and are responsible for shigellosis or bacillary dysentery, an important cause of worldwide morbidity and mortality. METHODS: We studied the antibiotic resistance profiles of 122 Shigella spp. strains (81 S. flexneri, 41 S. sonnei, 1 S. boydii isolated from patients (female and male from 0 to 80 years of age presenting diarrhea in different districts of the State of Pará, in the North of Brazil. The antibiotic resistance of the strains, isolated from human fecal samples, was determined by the diffusion disk method and by using the VITEK-2 system. RESULTS: The highest resistance rate found was the resistance rate to tetracycline (93.8%, followed by the resistance rate to chloramphenicol (63.9% and to trimethoprim/sulfamethoxazole (63.1%. Resistance to at least three drugs was more common among S. flexneri than S. sonnei (39.5% vs. 10%. Six (4.9% strains were susceptible to all the antibiotics tested. All strains were susceptible to cefotaxime, ceftazidime, ciprofloxacin, nalidixic acid and nitrofurantoin. CONCLUSIONS: High rates of multidrug resistance in Shigella spp. are a serious public health concern in Brazil. It is extremely important to continuously monitor the antimicrobial resistances of Shigella spp. for effective therapy and control measures against shigellosis.INTRODUÇÃO: Shigella spp. são bactérias Gram-negativas, não esporuladas, em forma de bastonete, pertencentes a família Enterobacteriaceae responsáveis pela shigelose ou disenteria bacilar, uma importante causa de mortalidade e morbidade mundial. MÉTODOS: Foi estudado o perfil de resistência a antimicrobianos de 122 amostras de Shigella spp. (81 S. flexneri, 41 sonnei, 1 S. boydii isoladas de pacientes (sexo feminino e masculino com faixa etária de 0 a 80 anos com distúrbios gastrointestinais em diferentes municípios no Estado do Par

  2. Prognostic value of suPAR and hs-CRP on cardiovascular disease

    DEFF Research Database (Denmark)

    Diederichsen, Marie Zöga; Diederichsen, Søren Zöga; Mickley, Hans

    2018-01-01

    Background and aims: Studies have shown that soluble urokinase Plasminogen Activator Receptor (suPAR) and CRP (both inflammatory markers) and coronary artery calcification (CAC) are independent risk predictors for cardiovascular (CV) disease. The aim of this study is to assess whether suPAR and CRP...... have an increased predictive prognostic value beyond the traditional CV risk factors and the CAC score. Methods: A population sample of 1179 subjects, free of CV disease was included. The subjects underwent traditional CV risk evaluation, CAC assessment and blood sampling for suPAR and CRP. CV events...

  3. Profils des enfants infectes par le vih en debut du traitement ...

    African Journals Online (AJOL)

    But : Décrire les profils des enfants infectés par le VIH au début du traitement antirétroviral. Matériels et méthode: Les dossiers des enfants infectés par le VIH dans la région maritime ont été analysés de mai 2008 à février 2010 par le comité thérapeutique. Résultats: Parmi les 96 dossiers analysés, 66,67% venaient du ...

  4. MODELISATION DE LA CINETIQUE CHIMIQUE DANS LA REDUCTION DES OXYDES D4AZOTE PAR DECHARGE COURONNE.

    OpenAIRE

    MEDJAHDI, Sarah ines

    2015-01-01

    CE TRAVAIL DE recherche rentre dans le cadre général de modélisation de la réduction des oxydes d'azote . l'utilisation des réacteurs a plasma froid non-thermique généré par des décharges couronnes est actuellement l'une des techniques les puis promettre .ses pour la destruction des oxydes d'azote .en effet , le traitement des gaz pollués par les décharges couronnes est notamment rendu possible par la multiplication des décharges Électriques .

  5. Thrombin induces rapid PAR1-mediated non-classical FGF1 release

    International Nuclear Information System (INIS)

    Duarte, Maria; Kolev, Vihren; Soldi, Raffaella; Kirov, Alexander; Graziani, Irene; Oliveira, Silvia Marta; Kacer, Doreen; Friesel, Robert; Maciag, Thomas; Prudovsky, Igor

    2006-01-01

    Thrombin induces cell proliferation and migration during vascular injury. We report that thrombin rapidly stimulated expression and release of the pro-angiogenic polypeptide fibroblast growth factor 1 (FGF1). Thrombin failed to induce FGF1 release from protease-activated receptor 1 (PAR1) null fibroblasts, indicating that this effect was dependent on PAR1. Similarly to thrombin, FGF1 expression and release were induced by TRAP, a specific oligopeptide agonist of PAR1. These results identify a novel aspect of the crosstalk between FGF and thrombin signaling pathways which both play important roles in tissue repair and angiogenesis

  6. Complexation de l'aluminium par des hétéropolyanions lacunaires ...

    African Journals Online (AJOL)

    L'objectif visé par cette étude est la dépollution des eaux à partir de la complexation d'un métal toxique, l'aluminium en solution, par des hétéropolyanions lacunaires (HPA) de type Dawson. Les complexes formés sont récupérés par membrane liquide émulsionnée (MEL).Les résultats de la complex1ation de l'aluminium ...

  7. Influence of P-Reactor operation on the aquatic ecology of Par Pond: a literature review

    International Nuclear Information System (INIS)

    Wilde, E.W.; Tilly, L.J.

    1985-02-01

    Par Pond is a 1012 hectare reservoir that was constructed in 1958 to provide cooling water for Savannah River nuclear reactors. The purpose of this report is to summarize all known studies on the Par Pond system and point out demonstrable or probable effects that can be correlated with reactor operations. Reactor operation effects the Par Pond ecosystem through: (1) pumping, (2) thermal alteration, and (3) the addition of Savannah River makeup water. The influence of each of these factors is discussed. 108 references, 24 figures, 34 tables. (MF)

  8. Monoradiculopathy and secondary segmental instability caused by postoperative pars interarticularis fracture: a case report.

    Science.gov (United States)

    Kaner, Tuncay; Tutkan, Ibrahim

    2009-04-01

    Instability can develop after lumbar spinal surgery. What is also known as secondary segmental instability is one of the important causes of failed back syndrome. In this paper, we described a 45-year-old female patient who was diagnosed with secondary segmental instability caused by left L3 pars interarticularis fracture after a high lumbar disc surgery and was subsequently treated with re-operation. We evaluated the clinical course, diagnosis, and treatment methods for secondary segmental instability caused by postoperative pars interarticularis fracture. Furthermore, we emphasized the importance of preserving the pars interarticularis during upper lumbar disc surgeries in order to avoid a potential stress fracture.

  9. L’utilisation d’internet par les parents d’enfants ayant un trouble du spectre de l’autisme / Internet use by parents of children with autism spectrum disorders

    Directory of Open Access Journals (Sweden)

    Georgette Goupil

    2014-05-01

    Full Text Available Le WEB représente une source importante d’information en matière de santé ou de déficience. Toutefois, peu d'études décrivent la fréquence d'utilisation d'Internet et les données consultées par les parents d’enfants qui ont un ont trouble du spectre de l’autisme (TSA. Cette étude a pour objectif de décrire la fréquence et la durée des recherches de ces parents sur Internet, les sites et le type d'information consultée en ligne, leurs perceptions de l'utilité de l'information et de son effet sur l’anxiété. Cent vingt-trois parents d'enfants ayant un TSA ont rempli un questionnaire d'enquête. Parmi les participants, 90% utilisent Internet pour recueillir des informations sur les TSA. Les données indiquent une fréquence d’utilisation élevée, plus grande que celle en général observée auprès de la population en matière de santé. Les mères consultent plus que les pères et il y a une relation positive entre la récence du diagnostic et la fréquence des consultations. Il y a peu de différence dans les perceptions des parents sur l’utilité entre les sites, tous étant jugés utiles ou très utiles. La discussion soulève la question de la discrimination par les parents de la qualité de l’information et des effets des recherches sur leurs choix d’intervention. The Web is an important source of information on health and disability; however, few studies describe the frequency of Internet use and the data accessed by the parents of children who have autism spectrum disorders (ASD. The objective of this study is to describe the frequency and duration of the online research conducted by these parents, the Internet sites and the type of information available online, parents’ perceptions of the usefulness of the information and its effect on anxiety. 123 parents of children with ASD completed a questionnaire. Among the participants, 90% used the Internet to find information about ASD. The data indicate higher

  10. Academic Publications

    OpenAIRE

    Francisco H C Felix

    2017-01-01

    Alternative modes of academic publication. What it is: Page for the dissemination of academic papers in alternative formats. Aimed at the diffusion of the idea of open publication, or open access publication, a branch of open science, a multidisciplinary movement that seeks to modify the paradigm of knowledge production that centralizes it and prevents its spreading. Historically, Western tradition has become firmly rooted in the free dissemination of knowledge among peers. However, the c...

  11. Public transport

    OpenAIRE

    Lethbridge, Jane

    2008-01-01

    Public transport plays an essential role in enabling people from low income and other disadvantaged groups to access employment and services. It also contributes to the development of social networks and social capital, by helping people to visit friends and relatives and take part in community and other social activities. Public policy makers have begun to recognise that adequate public transport provision can play an important role in reducing social exclusion. [Taken from introductory para...

  12. Influencia de los parámetros de proceso, en el comportamiento del parámetro vibración absoluta en turbinas de vapor.

    Directory of Open Access Journals (Sweden)

    F. de la Torre Silva

    2008-01-01

    Full Text Available Este trabajo muestra el estudio realizado en turbinas de vapor de pequeña capacidad de generación de las centrales termoeléctricas cubanas, relacionadas con la influencia estadística entre parámetros de proceso de la turbina, respecto al parámetro vibración absoluta, medidos en las chumaceras de la turbina. Se utilizan las bases de datos de los sistemas de monitoreado on-line de la turbina. Se exponen las relaciones existentes entre los principales parámetros seleccionados para este estudio.This work show the study in small steam turbine capacity of generation in cubans thermoelectric power station to relative with statistical influence between steam process parameters regarding absolute vibration parameter, in the steam housing measurements. Themselves use database as steam on-line monitoring systems. Expose the existing relation between the principal selection parameters for this study.

  13. Sir Mokshagundam Visvesvaraya–A Visionary Engineer par ...

    Indian Academy of Sciences (India)

    ing a social purpose. He was also ... public works engineer in March 1884 with the. Government of ... An opportunity to demonstrate his innovative abilities ... Another innovation which was .... Science - its highest policy making body - till. 1947.

  14. Efficacy and safety of the pars plana clip in the Ahmed valve device inserted via the pars plana in patients with refractory glaucoma

    Directory of Open Access Journals (Sweden)

    Manuel Diaz-Llopis

    2010-05-01

    Full Text Available Manuel Diaz-Llopis1,2,3, David Salom1,3, Salvador García-Delpech1,2,3, Patricia Udaondo1,3, Jose Maria Millan3,5, J Fernando Arevalo61Department of Ophthalmology, La Fe University Hospital of Valencia, Valencia, Spain; 2Department of Ophthalmology of the Valencia University, Valencia, Spain; 3Biomedical Network Research Centre on Rare Diseases (CIBERER, Valencia, Spain; 4Catholic University San Vicente Martir, Valencia, Spain; 5Department of Genetics, La Fe University Hospital of Valencia, Valencia, Spain; 6Clinica Oftalmologica Centro Caracas, Retina and VItreous Service, Caracas, DC, VenezuelaPurpose: To evaluate the efficacy and safety of the pars plana clip (PPC in the Ahmed valve tube inserted via the pars plana in patients with secondary refractory glaucomas.Methods: Prospective and interventional case series that included 10 patients with secondary refractory glaucoma. The pars plana vitrectomy and the implant of the modified tube were performed during the same surgery. Control of intraocular pressure (IOP and the development of intra- and postoperative complications were evaluated during the follow-up.Results: Follow-up time was twelve months in all the patients. Control of IOP was achieved in 90% of patients, and 70% needed no antiglaucoma treatment. The complications that occurred were transient hypotony in three cases, choroidal detachment in two cases, and one case of intraocular hemorrhage. No case of tube extrusion or tube kink was observed.Conclusions: Our data suggests that implantation of the Ahmed tube modified with the PPC via the pars plana is safe and effective in patients with secondary refractory glaucomas. Keywords: pars plana clip, Ahmed valve, refractory glaucoma, pars plana vitrectomy

  15. A mechanism for ParB-dependent waves of ParA, a protein related to DNA segregation during cell division in prokaryotes

    DEFF Research Database (Denmark)

    Hunding, Axel; Gerdes, Kenn; Charbon, Gitte Ebersbach

    2003-01-01

    in an autocatalytic process. We discuss this mechanism in relation to recent models for MinDE oscillations in E.coli and to microtubule degradation in mitosis. The study points to an ancestral role for the presented pattern types in generating bipolarity in prokaryotes and eukaryotes.......Prokaryotic plasmids encode partitioning (par) loci involved in segregation of DNA to daughter cells at cell division. A functional fusion protein consisting of Walker-type ParA ATPase and green fluorescent protein (Gfp) oscillates back and forth within nucleoid regions with a wave period of about...

  16. Outcome of early pars plana vitrectomy in exogenous endophthalmitis

    International Nuclear Information System (INIS)

    Dar, A.J.; Islam, Q.U.; Hanif, M.K.

    2013-01-01

    Objective: To evaluate the role of early pars plana vitrectomy (PPV) in cases of exogenous endophthalmitis in terms of final visual outcome and to determine association between various study variables and final visual outcome. Study Design: Quasi experimental study. Place and Duration of Study: Armed Forces Institute of Ophthalmology (AFIO) Rawalpindi, from Aug 2010 to May 2012. Patients and Methods: Eleven cases of exogenous endophthalmitis (post surgical/post traumatic) were managed surgically through 20 G or 23/25 G complete and early PPV. Vitreous aspirate/explanted intraocular lens (IOL) were sent for culture and sensitivity in all cases. Intra and post operative complications were recorded and best corrected visual acuity (BCVA) at 3 months post operative interval was taken as final visual acuity. Results: Median age of study population was 55 years with male preponderance (64%). Approximately 2/3 rd of study population developed endophthalmitis within 6 weeks of surgery/trauma and 55% of patients were operated within 2 weeks of presentation. Positive culture from vitreous aspirate/IOL explant was obtained in 27% of cases. All the patients had initial BCVA in the range of counting finger (CF) at 2 meter to perception of light (PL+). However, 18% of the patients achieved final BCVA of 6/12 or better and 64% achieved final BCVA of 6/36 or better. Maculopathy (macular scar, macular pucker), corneal decompensation, corneal opacity and raised intraocular pressure were the major complications associated with compromised visual outcome. Conclusion: With the advancement in vitreoretinal surgical techniques and availability of more sophisticated viewing and illumination systems, early and complete vitrectomy for post operative or post traumatic endophthalmitis results in favorable visual outcome and early rehabilitation. (author)

  17. Intrinsic and integrative properties of substantia nigra pars reticulata neurons

    Science.gov (United States)

    Zhou, Fu-Ming; Lee, Christian R.

    2011-01-01

    The GABA projection neurons of the substantia nigra pars reticulata (SNr) are output neurons for the basal ganglia and thus critical for movement control. Their most striking neurophysiological feature is sustained, spontaneous high frequency spike firing. A fundamental question is: what are the key ion channels supporting the remarkable firing capability in these neurons? Recent studies indicate that these neurons express tonically active TRPC3 channels that conduct a Na-dependent inward current even at hyperpolarized membrane potentials. When the membrane potential reaches −60 mV, a voltage-gated persistent sodium current (INaP) starts to activate, further depolarizing the membrane potential. At or slightly below −50 mV, the large transient voltage-activated sodium current (INaT) starts to activate and eventually triggers the rapid rising phase of action potentials. SNr GABA neurons have a higher density of (INaT), contributing to the faster rise and larger amplitude of action potentials, compared with the slow-spiking dopamine neurons. INaT also recovers from inactivation more quickly in SNr GABA neurons than in nigral dopamine neurons. In SNr GABA neurons, the rising phase of the action potential triggers the activation of high-threshold, inactivation-resistant Kv3-like channels that can rapidly repolarize the membrane. These intrinsic ion channels provide SNr GABA neurons with the ability to fire spontaneous and sustained high frequency spikes. Additionally, robust GABA inputs from direct pathway medium spiny neurons in the striatum and GABA neurons in the globus pallidus may inhibit and silence SNr GABA neurons, whereas glutamate synaptic input from the subthalamic nucleus may induce burst firing in SNr GABA neurons. Thus, afferent GABA and glutamate synaptic inputs sculpt the tonic high frequency firing of SNr GABA neurons and the consequent inhibition of their targets into an integrated motor control signal that is further fine-tuned by neuromodulators

  18. PAR-1 and thrombin: the ties that bind the microenvironment to melanoma metastasis.

    Science.gov (United States)

    Zigler, Maya; Kamiya, Takafumi; Brantley, Emily C; Villares, Gabriel J; Bar-Eli, Menashe

    2011-11-01

    Progression of melanoma is dependent on cross-talk between tumor cells and the adjacent microenvironment. The thrombin receptor, protease-activated receptor-1 (PAR-1), plays a key role in exerting this function during melanoma progression. PAR-1 and its activating factors, which are expressed on tumor cells and the surrounding stroma, induce not only coagulation but also cell signaling, which promotes the metastatic phenotype. Several adhesion molecules, cytokines, growth factors, and proteases have recently been identified as downstream targets of PAR-1 and have been shown to modulate interactions between tumor cells and the microenvironment in the process of melanoma growth and metastasis. Inhibiting such interactions by targeting PAR-1 could potentially be a useful therapeutic modality for melanoma patients. ©2011 AACR.

  19. Application of passive auto catalytic recombiner (PAR) for BWR plants in Japan

    International Nuclear Information System (INIS)

    Kobayashi, K.; Murano, K.; Yamanari, S.; Yamamoto, Y.

    2001-01-01

    The passive auto-catalytic recombiner (PAR), which can recombine flammable gases such as hydrogen and oxygen with each other to avoid an explosion in case of a loss-of-coolant accident (LOCA), installed in the primary containment vessel does not require a power supply or dynamic equipment, while the existing flammability gas control system (FCS) of most BWRs as an outer loop of the primary containment vessel needs them to make flammable gases circulate through blowers and heaters in the system. PAR offers a number of advantages over existing FCS, such as high reliability, low cost due to much smaller amount of materials needed, good maintainability, good operability in case of a LOCA, and smaller space for installation. An experimental study has been carried out for the purpose of solving the problems of applying PAR to Japanese BWR plants instead of existing FCS, in which we grasped the basic characteristics of PAR. (author)

  20. Effects of solar PAR and UV radiation on tropical biofouling communities

    KAUST Repository

    Dobretsov, SV; Gosselin, L; Qian, P

    2010-01-01

    We investigated the effect of solar ultraviolet radiation (UVR) and photosynthetically active radiation (PAR) on the development of tropical micro- and macrofouling communities for 30 d. The experimental design involved 3 treatments: full spectrum

  1. uPAR Expression Pattern in Patients with Urothelial Carcinoma of the Bladder

    DEFF Research Database (Denmark)

    Dohn, Line Hammer; Pappot, Helle; Iversen, Benedikte Richter

    2015-01-01

    The objective of the present study was to confirm the expression and localisation pattern of the urokinase-type plasminogen activator receptor (uPAR) focusing on its possible clinical relevance in patients with urothelial neoplasia of the bladder. uPAR is a central molecule in tissue remodelling...... during cancer invasion and metastasis and is an established prognostic marker in various cancer diseases other than bladder cancer. Formalin-fixed and paraffin-embedded tumour-tissue blocks from 186 patients treated with radical cystectomy were analysed. uPAR expression was scored as either negative...... or positive as well as by the actual score. Separate scores were obtained for cancer cells, macrophages and myofibroblasts at the invasive front and in tumour core. We were able to confirm, in an independent patient cohort, the tissue expression and localisation pattern of uPAR as investigated...

  2. Contamination des eaux de puits traditionnels par les nitrates sur le ...

    African Journals Online (AJOL)

    SARAH

    30 juin 2014 ... Objectif : La contamination des eaux souterraines par les nitrates est un ... Methodology and Results: the origin of nitrate water from traditional wells of Lobo's watershed was ...... 12 water supply wells, Yucatan, Mexico.

  3. ParFit: A Python-Based Object-Oriented Program for Fitting Molecular Mechanics Parameters to ab Initio Data.

    Science.gov (United States)

    Zahariev, Federico; De Silva, Nuwan; Gordon, Mark S; Windus, Theresa L; Dick-Perez, Marilu

    2017-03-27

    A newly created object-oriented program for automating the process of fitting molecular-mechanics parameters to ab initio data, termed ParFit, is presented. ParFit uses a hybrid of deterministic and stochastic genetic algorithms. ParFit can simultaneously handle several molecular-mechanics parameters in multiple molecules and can also apply symmetric and antisymmetric constraints on the optimized parameters. The simultaneous handling of several molecules enhances the transferability of the fitted parameters. ParFit is written in Python, uses a rich set of standard and nonstandard Python libraries, and can be run in parallel on multicore computer systems. As an example, a series of phosphine oxides, important for metal extraction chemistry, are parametrized using ParFit. ParFit is in an open source program available for free on GitHub ( https://github.com/fzahari/ParFit ).

  4. Public Transparency

    OpenAIRE

    UNCTAD; World Bank

    2018-01-01

    This note provides guidance on the type of information about agricultural investments that investors and governments can make publicly available. Transparency about certain aspects of investments can improve relations between investors and communities, enable external stakeholders to hold investors to commitments, and improve investors’ public image. Although some information should be kep...

  5. Public relations

    International Nuclear Information System (INIS)

    1998-01-01

    Public relations activities continued in a well-proved form of organizing plant visits and Information Centre off - site activities. Bohunice NPPs were visited by the number of 7294 visitors in 1997. A brief account of activities in public relations carried out by the Nuclear power plants Jaslovske Bohunice in 1997 is presented

  6. Infection par le VIH chez les patientes atteintes de cancer du sein en ...

    African Journals Online (AJOL)

    L'objectif était de déterminer la prévalence de l'infection à VIH chez les patientes atteintes de cancer du sein et de comparer les caractéristiques anatomocliques et thérapeutiques de ces cancers du sein par rapports aux patientes non infectées par le VIH. Il s'agissait d'une étude rétrospective et analytique comparant les ...

  7. Molecular mechanism of bundle formation by the bacterial actin ParM

    Energy Technology Data Exchange (ETDEWEB)

    Popp, David, E-mail: dpopp@imcb.a-star.edu.sg [ERATO ' Actin Filament Dynamics' Project, Japan Science and Technology Corporation, c/o RIKEN Harima Institute at Spring 8, 1-1-1 Kouto, Sayo, Hyogo 679-5148 (Japan); Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, 138673 Singapore (Singapore); Narita, Akihiro [ERATO ' Actin Filament Dynamics' Project, Japan Science and Technology Corporation, c/o RIKEN Harima Institute at Spring 8, 1-1-1 Kouto, Sayo, Hyogo 679-5148 (Japan); Nagoya University Graduate School of Science, Structural Biology Research Center and Division of Biological Sciences, Furo-cho, Chikusa-ku, Nagoya 464-8601 (Japan); Iwasa, Mitsusada [ERATO ' Actin Filament Dynamics' Project, Japan Science and Technology Corporation, c/o RIKEN Harima Institute at Spring 8, 1-1-1 Kouto, Sayo, Hyogo 679-5148 (Japan); Maeda, Yuichiro [ERATO ' Actin Filament Dynamics' Project, Japan Science and Technology Corporation, c/o RIKEN Harima Institute at Spring 8, 1-1-1 Kouto, Sayo, Hyogo 679-5148 (Japan); Nagoya University Graduate School of Science, Structural Biology Research Center and Division of Biological Sciences, Furo-cho, Chikusa-ku, Nagoya 464-8601 (Japan); Robinson, Robert C. [Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, 138673 Singapore (Singapore)

    2010-01-22

    The actin homolog ParM plays a microtubule-like role in segregating DNA prior to bacterial cell division. Fluorescence and cryo-electron microscopy have shown that ParM forms filament bundles between separating DNA plasmids in vivo. Given the lack of ParM bundling proteins it remains unknown how ParM bundles form at the molecular level. Here we show using time-lapse TIRF microscopy, under in vitro molecular crowding conditions, that ParM-bundle formation consists of two distinct phases. At the onset of polymerization bundle thickness and shape are determined in the form of nuclei of short helically disordered filaments arranged in a liquid-like lattice. These nuclei then undergo an elongation phase whereby they rapidly increase in length. At steady state, ParM bundles fuse into one single large aggregate. This behavior had been predicted by theory but has not been observed for any other cytomotive biopolymer, including F-actin. We employed electron micrographs of ParM rafts, which are 2-D analogs of 3-D bundles, to identify the main molecular interfilament contacts within these suprastructures. The interface between filaments is similar for both parallel and anti-parallel orientations and the distribution of filament polarity is random within a bundle. We suggest that the interfilament interactions are not due to the interactions of specific residues but rather to long-range, counter ion mediated, electrostatic attractive forces. A randomly oriented bundle ensures that the assembly is rigid and that DNA may be captured with equal efficiency at both ends of the bundle via the ParR binding protein.

  8. Etude par simulation hil des performances d'un statcom pour la ...

    African Journals Online (AJOL)

    Ce travail présente l'étude par simulation Hardware In the Loop (HIL) des performances d'un STATCOM pour la stabilisation de la tension délivrée par une génératrice asynchrone triphasée auto excitée dans un réseau autonome. Nous avons combiné l'utilisation du logiciel de simulation LABVIEW et la carte ARDUINO ...

  9. The superoxide scavenger TEMPOL induces urokinase receptor (uPAR expression in human prostate cancer cells

    Directory of Open Access Journals (Sweden)

    Francis Joseph

    2006-06-01

    Full Text Available Abstract There is little understanding of the effect that reactive oxygen metabolites have on cellular behavior during the processes of invasion and metastasis. These oxygen metabolites could interact with a number of targets modulating their function such as enzymes involved in basement membrane dissolution, adhesion molecules involved in motility or receptors involved in proliferation. We investigated the effect of increased scavenging of superoxide anions on the expression of the urokinase receptor (uPAR in PC-3M human prostate cancer cells. Urokinase receptor is a GPI-linked cell surface molecule which mediates multiple functions including adhesion, proliferation and pericellular proteolysis. Addition of the superoxide scavenger 4-hydroxy-2,2,6,6-tetramethylpiperidinyloxy (TEMPOL to PC-3M cultures stimulated expression of uPAR protein peaking between 48 and 72 hours. Cell surface expression of the uPAR was also increased. Surprisingly, uPAR transcript levels increased only slightly and this mild increase did not coincide with the striking degree of protein increase. This disparity indicates that the TEMPOL effect on uPAR occurs through a post-transcriptional mechanism. TEMPOL presence in PC-3M cultures reduced intracellular superoxide-type species by 75% as assayed by NBT dye conversion; however this reduction significantly diminished within hours following TEMPOL removal. The time gap between TEMPOL treatment and peak uPAR protein expression suggests that reduction of reactive oxygen metabolites in prostate cancer cells initiates a multistep pathway which requires several hours to culminate in uPAR induction. These findings reveal a novel pathway for uPAR regulation involving reactive oxygens such as superoxide anion.

  10. Compression robuste du signal par la transformée avec les B ...

    African Journals Online (AJOL)

    Par contre, elle diminue de façon considérable pour les b-splincs et les paquets dbndelcttes de Haar. Du point de vue entropie, la compression par bfsplines est bonne que celle de la TCD. Nous donnons ci-dessous un tableau récapitulatif des résultats de quelques méthodes utilisées pour deux signaux EMG. Le facteur de ...

  11. SuPAR predicts postoperative complications and mortality in patients with asymptomatic aortic stenosis

    DEFF Research Database (Denmark)

    Hodges, Gethin W; Bang, Casper N; Eugen-Olsen, Jesper

    2018-01-01

    complications with a HR of 2.7 (95% CI 1.5 to 5.1, P=0.002), per doubling in suPAR. After adjusting for the European System for Cardiac Operative Risk Evaluation or Society of Thoracic Surgeons risk score, suPAR remained associated with postoperative mortality with a HR 3.2 (95% CI 1.2 to 8.6, P=0.025) and 2...

  12. Hep par-1: a novel immunohistochemical marker for differentiating hepatocellular carcinoma from metastatic carcinoma

    International Nuclear Information System (INIS)

    Hanif, R.

    2014-01-01

    To evaluate the diagnostic utility of Hep par-1 in differentiating hepatocellular carcinoma from metastatic carcinoma taking histopathology as a gold standard. Study Design: Comparative cross-sectional study. Place and Duration of Study: Pathology Department, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, from April 2007 to February 2008. Methodology: Hep par-1 immunohistochemical stain was performed on 60 cases of liver carcinoma, 30 cases each of metastatic and hepatocellular carcinoma. Information regarding patient age, gender, sign and symptoms, radiographic findings, histological grade of tumour, and expression of Hep par-1 on hepatocellular and metastatic carcinoma were recorded on proforma sheet. Sensitivity, specificity, positive and negative predictive values, and accuracy of Hep par-1 were calculated using the formulas. Results: Hep par-1 expression was noted in 25 out of 30 cases of hepatocellular carcinoma (83%). Out of 30 cases of metastatic carcinoma, only one case expressed staining in < 5% tumour cells and remaining 29 cases showed no reactivity. The age of the patients with hepatocellular carcinoma ranged from 40 to 76 years with a median age of 60.5 years and 40 - 75 years for metastatic carcinomas with a median age of 57.5 years. Conclusion: Hep par-1 is a reliable immunohistochemical marker for cases of hepatocellular carcinoma (HCC). It can be used along with other markers in morphologically difficult cases when differential diagnosis lies between poorly differentiated HCC and metastatic carcinoma of liver. (author)

  13. Par and IR reflectance, transmittance, and absorptance of four crop canopies

    International Nuclear Information System (INIS)

    Wanjura, D.F.; Hatfield, J.L.

    1986-01-01

    Reflectance, transmittance and absorptance of electromagnetic radiation by cotton, soybeans, grain sorghum, and sunflower was measured at three growth stages in two wavebands (PAR: 0.4 to 0.7 pun and IR: 0.7 to 1.1 yim). As leaf area increased in each crop there were increases in IR reflectance and PAR absorptance and decreases in PAR reflectance and both PAR and IR transmittance. IR radiation was concentrated at the soil surface between rows by reflectance from the sides of canopies when crop cover was less than 80%. Across all crops one parameter, leaf overlap index, explained 81 and 71% of the PAR reflectance and another, crop cover, explained 86 and 94% of IR reflectance from rows and interrows, respectively. Attenuation of PAR radiation through the canopies of cotton and sunflower was similar (K = 0.62 and 0.67) but different from that of soybeans and grain sorghum (K = 0.46 and 0.43) which were the same

  14. Numerical analysis of the influence of PAR unit elevation within a vessel on its performance

    International Nuclear Information System (INIS)

    Kotouč, Miroslav

    2011-01-01

    On the basis of successful validation of the MELCOR code on several experiments from the international OECD/NEA programme THAI, a numerical parametric study has been conducted at NRI Řež evaluating the influence of PAR's vertical position within a vessel on its performance. Simulations were carried out for an Areva PAR unit which was considered to be placed at 5 different elevations in the THAI test vessel, the sixth simulation comprised a model of blower, simulating thus forced convection. The initial conditions were those of the THAI HR-12 test, which was characterized by steam-saturated atmosphere at elevated pressure and temperature. The results show that the overall hydrogen mass recombined monotonically decreases with PAR elevation. This behavior is due to hot, light and hydrogen-lean plume, coming out from the PAR outlet, which, due to buoyancy forces, eventually fills the upper part of the vessel and prevents thus the PAR unit from efficient operation (if the latter is placed near the top). It was also demonstrated that the effect of forced convection is favorable since it breaks the gas stratification and increases thus hydrogen concentration at the PAR inlet. (author)

  15. Factor Xa stimulates fibroblast procollagen production, proliferation, and calcium signaling via PAR1 activation

    International Nuclear Information System (INIS)

    Blanc-Brude, Olivier P.; Archer, Fabienne; Leoni, Patricia; Derian, Claudia; Bolsover, Steven; Laurent, Geoffrey J.; Chambers, Rachel C.

    2005-01-01

    Fibroblast proliferation and procollagen production are central features of tissue repair and fibrosis. In addition to its role in blood clotting, the coagulation cascade proteinase thrombin can contribute to tissue repair by stimulating fibroblasts via proteolytic activation of proteinase-activated receptor-1 (PAR 1 ). During hemostasis, the coagulation cascade proteinase factor X is converted into factor Xa. We have previously shown that factor Xa upregulates fibroblast proliferation via production of autocrine PDGF. In this study, we further examined the effects of factor Xa on fibroblast function and aimed to identify its signaling receptor. We showed that factor Xa stimulates procollagen promoter activity and protein production by human and mouse fibroblasts. This effect was independent of PDGF and thrombin production, but dependent on factor Xa proteolytic activity. We also showed that PAR 1 -deficient mouse fibroblasts did not upregulate procollagen production, mobilize cytosolic calcium, or proliferate in response to factor Xa. Desensitization techniques and PAR 1 -specific agonists and inhibitors were used to demonstrate that PAR 1 mediates factor Xa signaling in human fibroblasts. This is the first report that factor Xa stimulates extracellular matrix production. In contrast with endothelial cells and vascular smooth muscle cells, fibroblasts appear to be the only cell type in which the effects of factor Xa are mediated mainly via PAR 1 and not PAR 2 . These findings are critical for our understanding of tissue repair and fibrotic mechanisms, and for the design of novel approaches to inhibit the profibrotic effects of the coagulation cascade without compromising blood hemostasis

  16. Elevated soluble urokinase plasminogen activator receptor (suPAR) predicts mortality in Staphylococcus aureus bacteremia

    DEFF Research Database (Denmark)

    Mölkänen, T; Ruotsalainen, E; Thorball, C W

    2011-01-01

    The soluble form of urokinase-type plasminogen activator receptor (suPAR) is a new inflammatory marker. High suPAR levels have been shown to associate with mortality in cancer and in chronic infections like HIV and tuberculosis, but reports on the role of suPAR in acute bacteremic infections...... are scarce. To elucidate the role of suPAR in a common bacteremic infection, the serum suPAR levels in 59 patients with Staphylococcus aureus bacteremia (SAB) were measured using the suPARnostic ELISA assay and associations to 1-month mortality and with deep infection focus were analyzed. On day three, after...... the first positive blood culture for S. aureus, suPAR levels were higher in 19 fatalities (median 12.3; range 5.7-64.6 ng/mL) than in 40 survivors (median 8.4; range 3.7-17.6 ng/mL, p = 0.002). This difference persisted for 10 days. The presence of deep infection focus was not associated with elevated su...

  17. Brief communication: Population variation in human maxillary premolar accessory ridges (MxPAR).

    Science.gov (United States)

    Burnett, Scott E; Hawkey, Diane E; Turner, Christy G

    2010-02-01

    The purpose of this brief communication is to report the results of an analysis of maxillary premolar accessory ridges (MxPAR), a common but understudied accessory ridge that may occur both mesial and distal to the central ridge of the buccal cusp of upper premolars. We developed a new five-grade scoring plaque to better categorize MxPAR variation. Subsequently, we conducted a population analysis of MxPAR frequency in 749 dental casts of South African Indian, American Chinese, Alaskan Eskimo, Tohono O'odham (Papago), Akimel O'odham (Pima), Solomon Islander, South African Bantu, and both American and South African Whites. Northeast Asian and Asian-derived populations exhibited the highest MxPAR frequencies while Indo-European samples (South African Indians, American and South African Whites) exhibited relatively low frequencies. The Solomon Islanders and South African Bantu samples exhibited intermediate frequencies. Our analysis indicates that statistically significant differences in MxPAR frequency exist between major geographic populations. As a result, the MxPAR plaque has now been added to the Arizona State University Dental Anthropology System, an important contribution as maxillary premolar traits are underrepresented in analyses of dental morphology. 2009 Wiley-Liss, Inc.

  18. Examining relational empowerment for elementary school students in a yPAR program.

    Science.gov (United States)

    Langhout, Regina Day; Collins, Charles; Ellison, Erin Rose

    2014-06-01

    This paper joins relational empowerment, youth empowerment, and Bridging Multiple Worlds frameworks to examine forms of relational empowerment for children in two intermediary institutions-school and a youth participatory action research after-school program (yPAR ASP). Participants were twelve children, most of whom were Latina/o and from im/migrant families, enrolled in a yPAR ASP for 2 years. A mixed-method approach was utilized; we analyzed children's interviews, self-defined goals, and their social networks to examine their experiences of relational empowerment. We conclude that children experienced each of the five relational empowerment factors-collaborative competence, bridging social divisions, facilitating others' empowerment, mobilizing networks, and passing on a legacy-in the yPAR ASP setting, and some factors in school. These experiences, however, were more pronounced in the yPAR ASP setting. Additionally, social network analyses revealed that a small but meaningful percentage of actors bridged worlds, especially home and family, but by year 2, also school and the yPAR ASP. Finally, most helpers for school-based goals came from school, but a sizable number came from family, friends, and home worlds, and by year 2, also came from the yPAR ASP. Implications range from theoretical to methodological development, including the use of social network analysis as a tool to descriptively examine relational power in context.

  19. Synthèse des approches probabilistes de la Life Time Value et premières propositions d'extension

    OpenAIRE

    Herbert Castéran

    2004-01-01

    La recherche marketing s’est longtemps caractérisée par son approche statique des comportements et attitudes des clientèles. Elle offre classiquement une analyse de ceux-ci pouvant conduire, dans les meilleurs cas, à une segmentation des publics. Toutefois elle éprouve des difficultés à se situer dans des approches résolument dynamiques. Audelà de méthodes sans réel fondement, la principale option retenue, pour ce faire, est celle des modèles économétriques (modèles de choix discrets, modèles...

  20. : Management and prevention of the risk of flood : the example of the risk prevention plan of the valley of Largue river (haut - Rhin, France)

    OpenAIRE

    With , Lauriane

    2007-01-01

    accessible sur http://www.cresat.uha.fr/presentation/plonearticle.2008-12-08.7240336541/; La Largue constitue un cas d'école particulièrement intéressant en termes d'étude géohistorique des risques d'inondations. En ce qui concerne tout d'abord le choix du site par les pouvoirs publics, l'enquête historique montre que la Largue a connu de multiples crues, d'intensité et de fréquence variable, dont les plus célèbres sont celles de septembre 1852, février 1860, octobre 1880, juin 1973 (comprise...

  1. Exploring factors influencing voluntary turnover intent of Generation X public servants: A South African case

    OpenAIRE

    Hester Nienaber; Vhusthilo Masibigiri

    2012-01-01

    Purpose: The purpose of this article is to report on the factors perceived to influence the turnover intent of Generation X public servants. The problem: The researcher investigated the factors that Generation X public servants in South Africa perceive as influencing their turnover intent. Design: The problem was studied by way of a case study. The data were collected by means of semi-structured interviews. A total of eight purposively selected Generation X public servants par...

  2. Publications, 1978

    International Nuclear Information System (INIS)

    Hilborn, H.S.

    1979-03-01

    This is a compilation of documents that communicate the results of scientific and technical work done at Savannah River. The compilation includes those documents that have been published (research and development reports, journal articles, book chapters, etc.), documents that have been announced in Energy Research Abstracts, and papers that have been presented at technical meetings but have not yet been published or announced. The information was compiled by machine methods to produce bibliographic, subject, and author listings. This report updates the information included in DP-929, Rev. 2, Publications, 1951 through 1971 DP-929-1, Publications, 1972 through 1976, and DP-929-1, Supplement 1, Publications, 1977

  3. Parijs is een meervoud. Adriaan van Dis en de heruitvinding van de Hollander in Parijs

    NARCIS (Netherlands)

    Koffeman, M.N.; Koffeman, Maaike; Montoya, Alicia C.; Smeets, Marc

    2017-01-01

    Parijs, tot halverwege de 20ste eeuw het onbetwiste centrum van de Europese cultuur, heeft van oudsher een grote aantrekkingskracht uitgeoefend op Nederlandse kunstenaars en schrijvers. Velen van hen verbleven er kortere of langere tijd, op zoek naar internationale erkenning. De vrijere seksuele moraal

  4. La cohérence des choix des consommateurs suisses

    OpenAIRE

    Aurelio Mattei

    1994-01-01

    In this article we analyze if consumer behavior is consistent with utility maximization by using Swiss household budget data from 1975 to 1989. The test is based on revealed preference theory. We could follow the expenditures of 1840 households over 12 months and for 1730 households we could test their behavior for a greater number of months (up to 180 for 19 households). The results obtained with these panel data show that the traditional model of consumer behavior cannot explain the behavio...

  5. LES DETERMINANTS DE CHOIX DE L'IRRIGATION LOCALISEE ...

    African Journals Online (AJOL)

    sur l'information imparfaite, le risque, l'incertitude, les contraintes .... est sa vocation première. «Du fait de la ... montré que la taille d'une entreprise joue un rôle important quant à la ... Selon Featherstone et al., (1997), l'adoption d'une nouvelle pratique ..... feeding management for improved cattle in semiarid central Tan-.

  6. Modeling post-wildfire hydrological processes with ParFlow

    Science.gov (United States)

    Escobar, I. S.; Lopez, S. R.; Kinoshita, A. M.

    2017-12-01

    Wildfires alter the natural processes within a watershed, such as surface runoff, evapotranspiration rates, and subsurface water storage. Post-fire hydrologic models are typically one-dimensional, empirically-based models or two-dimensional, conceptually-based models with lumped parameter distributions. These models are useful for modeling and predictions at the watershed outlet; however, do not provide detailed, distributed hydrologic processes at the point scale within the watershed. This research uses ParFlow, a three-dimensional, distributed hydrologic model to simulate post-fire hydrologic processes by representing the spatial and temporal variability of soil burn severity (via hydrophobicity) and vegetation recovery. Using this approach, we are able to evaluate the change in post-fire water components (surface flow, lateral flow, baseflow, and evapotranspiration). This work builds upon previous field and remote sensing analysis conducted for the 2003 Old Fire Burn in Devil Canyon, located in southern California (USA). This model is initially developed for a hillslope defined by a 500 m by 1000 m lateral extent. The subsurface reaches 12.4 m and is assigned a variable cell thickness to explicitly consider soil burn severity throughout the stages of recovery and vegetation regrowth. We consider four slope and eight hydrophobic layer configurations. Evapotranspiration is used as a proxy for vegetation regrowth and is represented by the satellite-based Simplified Surface Energy Balance (SSEBOP) product. The pre- and post-fire surface runoff, subsurface storage, and surface storage interactions are evaluated at the point scale. Results will be used as a basis for developing and fine-tuning a watershed-scale model. Long-term simulations will advance our understanding of post-fire hydrological partitioning between water balance components and the spatial variability of watershed processes, providing improved guidance for post-fire watershed management. In reference

  7. Public Airports

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This data set is a vector point digital data structure that contains the locations of General Public Use Airports in the State of New Mexico. It only contains those...

  8. Public Sociology

    DEFF Research Database (Denmark)

    by the media? Does the choice of public sociology mean the relinquishment of scientific integrity and critical conviction? These questions will also be addressed in this book - together with a host of others related to the topic of public sociology.   The chapters included in this book are all manuscripts......What is the role of sociology in society? How can - and should - sociology contribute with insights relevant and useful to the outside world? Is sociology attuned to accommodate the demands of the wider public and of surrounding society? Who benefits from the knowledge produced and provided...... by sociology? What are the social implications and cultural effects of the knowledge sociology provides and creates? All of these questions, and many others, concern and centre on sociology's relationship to the surrounding society, in short to the ‘public'. All of these questions - and many others...

  9. Public meetings

    CERN Multimedia

    Staff Association

    2017-01-01

    Do you have questions about the elections to the Staff Council, 2017 MERIT exercise, EVE and School, LD to IC exercise, CHIS, the Pension Fund… Come get informed and ask your questions at our public meetings. These public meetings are also an opportunity to get the more information on current issues. Benefit from this occasion to get the latest news and to discuss with the representatives of the statutory body that is the Staff Association!

  10. Islam et engagements au Sénégal : résultats d'un programme de recherche demandé par l'Ambassade du Royaume des Pay-Bas à Dakar

    NARCIS (Netherlands)

    Kaag, M.M.A.

    2011-01-01

    Ce volume collectif rassemble les résultats de travaux menés par des chercheurs sénégalais et néerlandais selon trois axes de recherche concernant le Sénégal: la relation entre islam et politique, la relation entre islam et économie, le rôle de l'islam dans le débat public sur la bonne gouvernance.

  11. PARS risk charts: A 10-year study of risk assessment for cardiovascular diseases in Eastern Mediterranean Region.

    Directory of Open Access Journals (Sweden)

    Nizal Sarrafzadegan

    Full Text Available This study was designed to develop a risk assessment chart for the clinical management and prevention of the risk of cardiovascular disease (CVD in Iranian population, which is vital for developing national prevention programs. The Isfahan Cohort Study (ICS is a population-based prospective study of 6504 Iranian adults ≥35 years old, followed-up for ten years, from 2001 to 2010. Behavioral and cardiometabolic risk factors were examined every five years, while biennial follow-ups for the occurrence of the events was performed by phone calls or by verbal autopsy. Among these participants, 5432 (2784 women, 51.3% were CVD free at baseline examination and had at least one follow-up. Cox proportional hazard regression was used to predict the risk of ischemic CVD events, including sudden cardiac death due to unstable angina, myocardial infarction, and stroke. The model fit statistics such as area under the receiver-operating characteristic (AUROC, calibration chi-square and the overall bias were used to assess the model performance. We also tested the Framingham model for comparison. Seven hundred and five CVD events occurred during 49452.8 person-years of follow-up. The event probabilities were calculated and presented color-coded on each gender-specific PARS chart. The AUROC and Harrell's C indices were 0.74 (95% CI, 0.72-0.76 and 0.73, respectively. In the calibration, the Nam-D'Agostino χ2 was 10.82 (p = 0.29. The overall bias of the proposed model was 95.60%. PARS model was also internally validated using cross-validation. The Android app and the Web-based risk assessment tool were also developed as to have an impact on public health. In comparison, the refitted and recalibrated Framingham models, estimated the CVD incidence with the overall bias of 149.60% and 128.23% for men, and 222.70% and 176.07% for women, respectively. In conclusion, the PARS risk assessment chart is a simple, accurate, and well-calibrated tool for predicting a 10-year

  12. uPA/uPAR system activation drives a glycolytic phenotype in melanoma cells.

    Science.gov (United States)

    Laurenzana, Anna; Chillà, Anastasia; Luciani, Cristina; Peppicelli, Silvia; Biagioni, Alessio; Bianchini, Francesca; Tenedini, Elena; Torre, Eugenio; Mocali, Alessandra; Calorini, Lido; Margheri, Francesca; Fibbi, Gabriella; Del Rosso, Mario

    2017-09-15

    In this manuscript, we show the involvement of the uPA/uPAR system in the regulation of aerobic glycolysis of melanoma cells. uPAR over-expression in human melanoma cells controls an invasive and glycolytic phenotype in normoxic conditions. uPAR down-regulation by siRNA or its uncoupling from integrins, and hence from integrin-linked tyrosine kinase receptors (IL-TKRs), by an antagonist peptide induced a striking inhibition of the PI3K/AKT/mTOR/HIF1α pathway, resulting into impairment of glucose uptake, decrease of several glycolytic enzymes and of PKM2, a checkpoint that controls metabolism of cancer cells. Further, binding of uPA to uPAR regulates expression of molecules that govern cell invasion, including extracellular matrix metallo-proteinases inducer (EMPPRIN) and enolase, a glycolytyc enzyme that also serves as a plasminogen receptor, thus providing a common denominator between tumor metabolism and phenotypic invasive features. Such effects depend on the α5β1-integrin-mediated uPAR connection with EGFR in melanoma cells with engagement of the PI3K-mTOR-HIFα pathway. HIF-1α trans-activates genes whose products mediate tumor invasion and glycolysis, thus providing the common denominator between melanoma metabolism and its invasive features. These findings unveil a unrecognized interaction between the invasion-related uPAR and IL-TKRs in the control of glycolysis and disclose a new pharmacological target (i.e., uPAR/IL-TKRs axis) for the therapy of melanoma. © 2017 UICC.

  13. Lumbar lordosis and pars interarticularis fractures: a case-control study

    International Nuclear Information System (INIS)

    Bugg, William G.; Lewis, Mark; Juette, Arne; Cahir, John G.; Toms, Andoni P.

    2012-01-01

    The aim of this study is to examine the relationship between lumbar lordosis and pars interarticularis fractures. In this retrospective case-control study we compare the angle of lumbar lordosis and the angle of the S1 vertebral endplate (as a measure of pelvic tilt) in patients with bilateral L5 pars interarticularis fractures with age- and sex-matched control cases with normal MRI examinations of the lumbar spine. Twenty-nine cases of bilateral L5 pars interarticularis fractures with matched control-cases were identified on MRI (16 male, 13 female, age 9-63 years). The angle of lordosis was measured between the inferior L4 and superior S1 vertebral endplates on a standing lateral lumbar spine radiograph for both groups. The mean angle of lordosis about the L5 vertebra was 36.9 (SD = 6.5 ) in the pars interarticularis fracture group, and 30.1 (SD = 6.4 ) in the control group. The difference between the two groups was significant (mean difference 6.8 , Student's t test: P < 0.001). The mean angle of sacral tilt measured was 122.2 (SD = 10.16 ) for controls and 136.4 (SD = 10.86 ) for patients with pars defects. The difference in the means of 14.2 was statistically significantly different (P < 0.0001). Sacral tilt represented by a steeply angled superior endplate of S1 is associated with a significantly increased angle of lordosis, between L4 and S1, and pars fractures at L5. Steep angulation of the first sacral vertebral segment maybe the predisposing biomechanical factor that leads to pincer-like impingement of the pars interarticularis and then spondylolysis. (orig.)

  14. Lumbar lordosis and pars interarticularis fractures: a case-control study

    Energy Technology Data Exchange (ETDEWEB)

    Bugg, William G; Lewis, Mark; Juette, Arne; Cahir, John G; Toms, Andoni P [Cotman Centre, Norwich Radiology Academy, Norwich, Norfolk (United Kingdom)

    2012-07-15

    The aim of this study is to examine the relationship between lumbar lordosis and pars interarticularis fractures. In this retrospective case-control study we compare the angle of lumbar lordosis and the angle of the S1 vertebral endplate (as a measure of pelvic tilt) in patients with bilateral L5 pars interarticularis fractures with age- and sex-matched control cases with normal MRI examinations of the lumbar spine. Twenty-nine cases of bilateral L5 pars interarticularis fractures with matched control-cases were identified on MRI (16 male, 13 female, age 9-63 years). The angle of lordosis was measured between the inferior L4 and superior S1 vertebral endplates on a standing lateral lumbar spine radiograph for both groups. The mean angle of lordosis about the L5 vertebra was 36.9 (SD = 6.5 ) in the pars interarticularis fracture group, and 30.1 (SD = 6.4 ) in the control group. The difference between the two groups was significant (mean difference 6.8 , Student's t test: P < 0.001). The mean angle of sacral tilt measured was 122.2 (SD = 10.16 ) for controls and 136.4 (SD = 10.86 ) for patients with pars defects. The difference in the means of 14.2 was statistically significantly different (P < 0.0001). Sacral tilt represented by a steeply angled superior endplate of S1 is associated with a significantly increased angle of lordosis, between L4 and S1, and pars fractures at L5. Steep angulation of the first sacral vertebral segment maybe the predisposing biomechanical factor that leads to pincer-like impingement of the pars interarticularis and then spondylolysis. (orig.)

  15. Lumbar lordosis and pars interarticularis fractures: a case-control study

    Energy Technology Data Exchange (ETDEWEB)

    Bugg, William G.; Lewis, Mark; Juette, Arne; Cahir, John G.; Toms, Andoni P. [Cotman Centre, Norwich Radiology Academy, Norwich, Norfolk (United Kingdom)

    2012-07-15

    The aim of this study is to examine the relationship between lumbar lordosis and pars interarticularis fractures. In this retrospective case-control study we compare the angle of lumbar lordosis and the angle of the S1 vertebral endplate (as a measure of pelvic tilt) in patients with bilateral L5 pars interarticularis fractures with age- and sex-matched control cases with normal MRI examinations of the lumbar spine. Twenty-nine cases of bilateral L5 pars interarticularis fractures with matched control-cases were identified on MRI (16 male, 13 female, age 9-63 years). The angle of lordosis was measured between the inferior L4 and superior S1 vertebral endplates on a standing lateral lumbar spine radiograph for both groups. The mean angle of lordosis about the L5 vertebra was 36.9 (SD = 6.5 ) in the pars interarticularis fracture group, and 30.1 (SD = 6.4 ) in the control group. The difference between the two groups was significant (mean difference 6.8 , Student's t test: P < 0.001). The mean angle of sacral tilt measured was 122.2 (SD = 10.16 ) for controls and 136.4 (SD = 10.86 ) for patients with pars defects. The difference in the means of 14.2 was statistically significantly different (P < 0.0001). Sacral tilt represented by a steeply angled superior endplate of S1 is associated with a significantly increased angle of lordosis, between L4 and S1, and pars fractures at L5. Steep angulation of the first sacral vertebral segment maybe the predisposing biomechanical factor that leads to pincer-like impingement of the pars interarticularis and then spondylolysis. (orig.)

  16. A method for estimating the diffuse attenuation coefficient (KdPAR)from paired temperature sensors

    Science.gov (United States)

    Read, Jordan S.; Rose, Kevin C.; Winslow, Luke A.; Read, Emily K.

    2015-01-01

    A new method for estimating the diffuse attenuation coefficient for photosynthetically active radiation (KdPAR) from paired temperature sensors was derived. We show that during cases where the attenuation of penetrating shortwave solar radiation is the dominant source of temperature changes, time series measurements of water temperatures at multiple depths (z1 and z2) are related to one another by a linear scaling factor (a). KdPAR can then be estimated by the simple equation KdPAR ln(a)/(z2/z1). A suggested workflow is presented that outlines procedures for calculating KdPAR according to this paired temperature sensor (PTS) method. This method is best suited for conditions when radiative temperature gains are large relative to physical noise. These conditions occur frequently on water bodies with low wind and/or high KdPARs but can be used for other types of lakes during time periods of low wind and/or where spatially redundant measurements of temperatures are available. The optimal vertical placement of temperature sensors according to a priori knowledge of KdPAR is also described. This information can be used to inform the design of future sensor deployments using the PTS method or for campaigns where characterizing sub-daily changes in temperatures is important. The PTS method provides a novel method to characterize light attenuation in aquatic ecosystems without expensive radiometric equipment or the user subjectivity inherent in Secchi depth measurements. This method also can enable the estimation of KdPAR at higher frequencies than many manual monitoring programs allow.

  17. RESOLUTION DU PROBLEME DE PREDICTION LINEAIRE PAR LA METHODE ULV. APPLICATION AU SIGNAL FID

    Directory of Open Access Journals (Sweden)

    M KHELIF

    2003-06-01

    Full Text Available Dans le cadre de la spectroscopie RMN, notre objectif est de déterminer le spectre d'absorption du signal de précession libre FID par la méthode de prédiction linéaire (PL. Ceci revient à résoudre le problème de prédiction linéaire en exploitant la méthode de corrélation par l'utilisation de la décomposition en valeurs singulières SVD pour l'inversion de la matrice de corrélation. Or, cette technique est la source d'un certain nombre de problèmes lorsque le signal est noyé dans du bruit. Aussi sera-t-elle coûteuse en temps lorsque les dimensions de la matrice de corrélation sont importantes. Afin de résoudre ce problème, nous exploitons les propriétés d'une nouvelle technique dérivée de la SVD, la décomposition ULV pour minimiser le coût du traitement et assurer une inversion correcte de la matrice de corrélation. Dans ce but, nous déterminons le spectre d'absorption par la technique ULV et nous le comparons avec le spectre déterminé par la SVD et  la FFT. Nous comparons par la suite la qualité des spectres obtenus par rapport au spectre d'absorption idéal  déterminé par FFT.

  18. El concurso de la Académie Royale de Médecine de Paris, 1843: Análisis contextual de la emergencia de los primeros trabajos acerca de la herencia de la locura (A. Gaussail y E. Gintrac The Académie Royale de Médecine de París' contest, 1843: Contextual analysis of the emergence of the first publications concerning the heredity of madness (A. Gaussail and E. Gintrac

    Directory of Open Access Journals (Sweden)

    Mauro Vallejo

    2010-12-01

    Full Text Available El objetivo del presente trabajo es analizar la emergencia de las primeras publicaciones francesas enteramente dedicadas a la temática de la herencia de las enfermedades mentales. Tal y como ha sido demostrado por otros investigadores, Francia fue el territorio donde con más insistencia y ahínco se abordó el problema de la herencia desde un punto de vista médico. A partir de 1850, gran parte del alienismo de ese país consideró que el fenómeno hereditario era un componente esencial de las patologías nerviosas. Luego de describir qué lugar asignaban a ese factor los psiquiatras de comienzos de siglo, este escrito propone considerar el saber médico sobre la herencia antes de 1850 a los fines de comprender cómo y porqué aparecen, a instancias de un concurso auspiciado por la Académie Royale de Médecine, los primeros tratados acerca del asunto, escritos por A. Gaussail y E. Gintrac.The purpose of this work is to analyze the appearance of the first French publications dealing with the heredity of mental illnesses. As it has been shown by others scholars, France was the country where the hereditarian subject was specially observed from a medical point of view. From 1850 a great part of the alienist profession considered that the heredity was a essential component of the mental pathologies. After describing the relevance that until 1850 the psychiatrists gave to that factor, this paper shows that the medical knowledge about heredity must be taken into account in order to understand how and why, ant thanks to a contest announced by the académie royale de médecine, the first treatises dealing with the subject (written by A. Gaussail and E. Gintrac finally appeared.

  19. Identification of a new epitope in uPAR as a target for the cancer therapeutic monoclonal antibody ATN-658, a structural homolog of the uPAR binding integrin CD11b (αM.

    Directory of Open Access Journals (Sweden)

    Xiang Xu

    Full Text Available The urokinase plasminogen activator receptor (uPAR plays a role in tumor progression and has been proposed as a target for the treatment of cancer. We recently described the development of a novel humanized monoclonal antibody that targets uPAR and has anti-tumor activity in multiple xenograft animal tumor models. This antibody, ATN-658, does not inhibit ligand binding (i.e. uPA and vitronectin to uPAR and its mechanism of action remains unclear. As a first step in understanding the anti-tumor activity of ATN-658, we set out to identify the epitope on uPAR to which ATN-658 binds. Guided by comparisons between primate and human uPAR, epitope mapping studies were performed using several orthogonal techniques. Systematic site directed and alanine scanning mutagenesis identified the region of aa 268-275 of uPAR as the epitope for ATN-658. No known function has previously been attributed to this epitope Structural insights into epitope recognition were obtained from structural studies of the Fab fragment of ATN-658 bound to uPAR. The structure shows that the ATN-658 binds to the DIII domain of uPAR, close to the C-terminus of the receptor, corroborating the epitope mapping results. Intriguingly, when bound to uPAR, the complementarity determining region (CDR regions of ATN-658 closely mimic the binding regions of the integrin CD11b (αM, a previously identified uPAR ligand thought to be involved in leukocyte rolling, migration and complement fixation with no known role in tumor progression of solid tumors. These studies reveal a new functional epitope on uPAR involved in tumor progression and demonstrate a previously unrecognized strategy for the therapeutic targeting of uPAR.

  20. Report made on behalf of the commission of economic affairs, of environment and of territory about the project of law, adopted by the Senate after urgency declaration (no. 326), relative to the energy markets and to the energy public utility; Rapport fait au nom de la commission des affaires economiques, de l'environnement et du territoire sur le projet de loi, adopte par le Senat apres declaration d'urgence (no. 326), relatif aux marches energetiques et au service public de l'energie

    Energy Technology Data Exchange (ETDEWEB)

    Gonnot, F.M

    2002-11-01

    This report concerns the transposition into French law of the directive 98/30/CE adopted by the European parliament and council on June 22, 1998, and concerning the common rules for the home natural gas market. In an introductory part, the report recalls first the principle and implementation of the regulation of the natural gas market (commission of energy regulation, role of the energy minister), and then explains its impact for the end-consumer and the conditions of the adaptation of the gas distribution network to this structure change (reinforcement of market contestableness, Gaz de France monopoly, competition between infrastructures, problem of investments coordination). The main part of the document concerns the works of the commission about the project of law adopted by the Senate, and the examination of its different articles: access to the natural gas networks, transparency and regulation of the natural gas sector, the gas public utility, the transport and distribution of natural gas, the underground storage, the control and sanctions, and the dispositions relative to the public electric utility. (J.S.)

  1. Publications | Page 84 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en ... Avec nos livres, nos articles, nos publications de recherche et nos études, ... Raisons de l'impact majeur des inondations provoquées par les crues de l'Indus en 2010 sur le Pakistan ... En Haïti, les signes de danger sautent littéralement aux yeux.

  2. CFD modelling of hydrogen stratification in enclosures: Model validation and application to PAR performance

    Energy Technology Data Exchange (ETDEWEB)

    Hoyes, J.R., E-mail: james.hoyes@hsl.gsi.gov.uk; Ivings, M.J.

    2016-12-15

    Highlights: • The ability of CFD to predict hydrogen stratification phenomena is investigated. • Contrary to expectation, simulations on tetrahedral meshes under-predict mixing. • Simulations on structured meshes give good agreement with experimental data. • CFD model used to investigate the effects of stratification on PAR performance. • Results show stratification can have a significant effect on PAR performance. - Abstract: Computational Fluid Dynamics (CFD) models are maturing into useful tools for supporting safety analyses. This paper investigates the capabilities of CFD models for predicting hydrogen stratification in a containment vessel using data from the NEA/OECD SETH2 MISTRA experiments. Further simulations are then carried out to illustrate the qualitative effects of hydrogen stratification on the performance of Passive Autocatalytic Recombiner (PAR) units. The MISTRA experiments have well-defined initial and boundary conditions which makes them well suited for use in a validation study. Results are presented for the sensitivity to mesh resolution and mesh type. Whilst the predictions are shown to be largely insensitive to the mesh resolution they are surprisingly sensitive to the mesh type. In particular, tetrahedral meshes are found to induce small unphysical convection currents that result in molecular diffusion and turbulent mixing being under-predicted. This behaviour is not unique to the CFD model used here (ANSYS CFX) and furthermore, it may affect simulations run on other non-aligned meshes (meshes that are not aligned perpendicular to gravity), including non-aligned structured meshes. Following existing best practice guidelines can help to identify potential unphysical predictions, but as an additional precaution consideration should be given to using gravity-aligned meshes for modelling stratified flows. CFD simulations of hydrogen recombination in the Becker Technologies THAI facility are presented with high and low PAR positions

  3. MARK/Par1 Kinase Is Activated Downstream of NMDA Receptors through a PKA-Dependent Mechanism.

    Directory of Open Access Journals (Sweden)

    Laura P Bernard

    Full Text Available The Par1 kinases, also known as microtubule affinity-regulating kinases (MARKs, are important for the establishment of cell polarity from worms to mammals. Dysregulation of these kinases has been implicated in autism, Alzheimer's disease and cancer. Despite their important function in health and disease, it has been unclear how the activity of MARK/Par1 is regulated by signals from cell surface receptors. Here we show that MARK/Par1 is activated downstream of NMDA receptors in primary hippocampal neurons. Further, we show that this activation is dependent on protein kinase A (PKA, through the phosphorylation of Ser431 of Par4/LKB1, the major upstream kinase of MARK/Par1. Together, our data reveal a novel mechanism by which MARK/Par1 is activated at the neuronal synapse.

  4. Increased plasma soluble uPAR level is a risk marker of respiratory cancer in initially cancer-free individuals

    DEFF Research Database (Denmark)

    Langkilde, Anne A; Hansen, Tine Willum; Ladelund, Steen

    2011-01-01

    BACKGROUND: Soluble urokinase plasminogen activator receptor (suPAR) is a stable plasma biomarker associated with inflammation and disease. This study tested the association between suPAR levels and incident respiratory, gastrointestinal or other types of cancer in initially cancer-free individuals...... with respiratory, gastrointestinal and other cancer types, respectively.CONCLUSIONS: Elevated suPAR levels were associated with increased risk of incident respiratory cancer and other types of cancer, but not gastrointestinal cancers, independently of established risk factors, CRP and leukocyte numbers. Impact.......RESULTS: suPAR levels ranged from 0.6-22 ng/ml, and median suPAR level was 4.01 ng/ml. 1 ng/ml increase in baseline suPAR was associated with adjusted hazard ratios (HR) of 1.61 (95% CI: 1.23-2.11, P

  5. Going public

    DEFF Research Database (Denmark)

    Meyer, Gitte; Sandøe, Peter

    2012-01-01

    conduct, contains a tacit maxim of openness which may naturally be extended to cover the public relations of science. Discussing openness as access, accountability, transparency and receptiveness, the argumentation concentrates on the possible prevention of misconduct with respect to, on the one hand......The paper addresses issues of scientific conduct regarding relations between science and the media, relations between scientists and journalists, and attitudes towards the public at large. In the large and increasing body of literature on scientific conduct and misconduct, these issues seem...... deal with ethical public relations issues, guided by a norm or maxim of openness. Drawing on and rethinking the CUDOS codification of the scientific ethos, as it was worked out by Robert K. Merton in 1942, we propose that this, which is echoed in current codifications of norms for good scientific...

  6. Public Sphere

    DEFF Research Database (Denmark)

    Trenz, Hans-Jörg

    2015-01-01

    In modern societies, the public sphere represents the intermediary realm that supports the communication of opinions, the discovery of problems that need to be dealt with collectively, the channeling of these problems through the filter of the media and political institutions, and the realization...... of the collective will of the people in the act of democratic self-government. The concept of the public sphere is used across the fields of media and communication research, cultural studies and the humanities, the history of ideas, legal and constitutional studies as well as democracy studies. Historically......, public spheres have undergone structural transformations that were closely connected to the emergence of different mass media. More recently, they are subject to trends of transnationalization and digitalization in politics and society....

  7. public spaces

    Directory of Open Access Journals (Sweden)

    Elena Grigoryeva

    2013-01-01

    Full Text Available The topic of this issue is PUBLIC SPACES. It is familiar and clear to every citizen. The streets and courtyards as childhood experiences remain with us forever. And these are the places where we come with our parents at weekends, where we meet friends, where we have dates and where we already come for a walk with our children.The history of public spaces is long and captivating. It was the main city squares where the most important events took place in history. The Agoras of Ancient Greece and the Roman Forums, the squares of Vatican, Paris and London, Moscow and Saint Petersburg… Greve, Trafalgar, Senate, Palace, Red, Bolotnaya – behind every name there is life of capitals, countries and nations.Public spaces, their shapes, image and development greatly influence the perception of the city as a whole. Both visitors and inhabitants can see in public spaces not only the visage but the heart, the soul and the mind of the city.Unfortunately, sometimes we have to prove the value of public spaces and defend them from those who consider them nothing but a blank space, nobody’s land destined for barbarous development.What should happen to make citizens perceive public spaces as their own and to make authorities consider development and maintenance of squares and parks their priority task against the  background of increasing competition between cities and the fight for human capital? Lately they more often say about “a high-quality human capital”. And now, when they say “the city should be liveable” they add “for all groups of citizens, including the creative class”.

  8. Public Performance

    Science.gov (United States)

    Krupp, E. C.

    2013-01-01

    America’s first planetaria all opened in the 1930s, and each was the distinctive product of local circumstances. In Los Angeles, the populist sensibilities of Griffith J. Griffith prompted him to value the transformative power of a personal encounter with a telescope, and he quickly embraced the idea of a public observatory with free access to all. Griffith Observatory and its planetarium emerged from that intent. Authenticity, intelligibility, and theatricality were fundamental principles in Griffith’s thinking, and they were transformed into solid and enduring scientific and astronomical values by those who actually guided the Observatory’s design, construction, and programming. That said, the public profile of Griffith Observatory was most defined by its inspired hilltop location, its distinctive, commanding architecture, and its felicitous proximity to Hollywood. The Observatory is theatric in placement and in appearance, and before the Observatory even opened, it was used as a motion picture set. That continuing vocation turned Griffith Observatory into a Hollywood star. Because entertainment industry objectives and resources were part of the Los Angeles landscape, they influenced Observatory programming throughout the Observatory’s history. Public astronomy in Los Angeles has largely been framed by the Observatory’s fundamental nature. It has exhibits, but it is not a museum. It has a planetarium, but it is essentially an observatory. As a public observatory, it is filled with instruments that transform visitors into observers. This role emphasized the importance of personal experience and established the perception of Griffith Observatory as a place for public gathering and shared contact with the cosmos. The Observatory’s close and continuous link with amateur astronomers made amateurs influential partners in the public enterprise. In full accord with Griffith J. Griffith’s original intent, Griffith Observatory has all been about putting

  9. Active zone proteins are transported via distinct mechanisms regulated by Par-1 kinase.

    Directory of Open Access Journals (Sweden)

    Kara R Barber

    2017-02-01

    Full Text Available Disruption of synapses underlies a plethora of neurodevelopmental and neurodegenerative disease. Presynaptic specialization called the active zone plays a critical role in the communication with postsynaptic neuron. While the role of many proteins at the active zones in synaptic communication is relatively well studied, very little is known about how these proteins are transported to the synapses. For example, are there distinct mechanisms for the transport of active zone components or are they all transported in the same transport vesicle? Is active zone protein transport regulated? In this report we show that overexpression of Par-1/MARK kinase, a protein whose misregulation has been implicated in Autism spectrum disorders (ASDs and neurodegenerative disorders, lead to a specific block in the transport of an active zone protein component- Bruchpilot at Drosophila neuromuscular junctions. Consistent with a block in axonal transport, we find a decrease in number of active zones and reduced neurotransmission in flies overexpressing Par-1 kinase. Interestingly, we find that Par-1 acts independently of Tau-one of the most well studied substrates of Par-1, revealing a presynaptic function for Par-1 that is independent of Tau. Thus, our study strongly suggests that there are distinct mechanisms that transport components of active zones and that they are tightly regulated.

  10. Removal of focal segmental glomerulosclerosis (FSGS) factor suPAR using CytoSorb.

    Science.gov (United States)

    Schenk, Heiko; Müller-Deile, Janina; Schmitt, Roland; Bräsen, Jan Hinrich; Haller, Hermann; Schiffer, Mario

    2017-12-01

    Treatment of primary focal segmental glomerulosclerosis (FSGS) and its recurrence after kidney transplantation associated with rapid deterioration of kidney function remains to be challenging despite advances in immunosuppressive therapy. The presence of circulating factors has been postulated to be a pivotal player in the pathogenesis of FSGS, although suPAR and CLCF-1 have been identified as the most promising causative factors. The potential therapeutic effect of suPAR elimination in an FSGS patient using CytoSorb, a hemoadsorption device that gained attention in the cytokine elimination in septic patients, was studied. Efficiency of total plasma exchange to remove suPAR was determined. CytoSorb hemoadsorption caused a 27.33% reduction of the suPAR level in a single treatment, whereas total plasma exchange showed a suPAR level reduction of 25.12% (n = 3; 95% confidence interval, 0.2777-0.8090; P < 0.01), which may indicate therapeutic potential in the treatment of primary FSGS and its recurrence in a kidney transplant. © 2017 Wiley Periodicals, Inc.

  11. Nanomechanical recognition of prognostic biomarker suPAR with DVD-ROM optical technology

    International Nuclear Information System (INIS)

    Bache, Michael; Bosco, Filippo G; Brøgger, Anna L; Frøhling, Kasper B; Boisen, Anja; Alstrøm, Tommy Sonne; Hwu, En-Te; Chen, Ching-Hsiu; Hwang, Ing-Shouh; Eugen-Olsen, Jesper

    2013-01-01

    In this work the use of a high-throughput nanomechanical detection system based on a DVD-ROM optical drive and cantilever sensors is presented for the detection of urokinase plasminogen activator receptor inflammatory biomarker (uPAR). Several large scale studies have linked elevated levels of soluble uPAR (suPAR) to infectious diseases, such as HIV, and certain types of cancer. Using hundreds of cantilevers and a DVD-based platform, cantilever deflection response from antibody–antigen recognition is investigated as a function of suPAR concentration. The goal is to provide a cheap and portable detection platform which can carry valuable prognostic information. In order to optimize the cantilever response the antibody immobilization and unspecific binding are initially characterized using quartz crystal microbalance technology. Also, the choice of antibody is explored in order to generate the largest surface stress on the cantilevers, thus increasing the signal. Using optimized experimental conditions the lowest detectable suPAR concentration is currently around 5 nM. The results reveal promising research strategies for the implementation of specific biochemical assays in a portable and high-throughput microsensor-based detection platform. (paper)

  12. PAR-1 mediated apoptosis of breast cancer cells by V. cholerae hemagglutinin protease.

    Science.gov (United States)

    Ray, Tanusree; Pal, Amit

    2016-05-01

    Bacterial toxins have emerged as promising agents in cancer treatment strategy. Hemagglutinin (HAP) protease secreted by Vibrio cholerae induced apoptosis in breast cancer cells and regresses tumor growth in mice model. The success of novel cancer therapies depends on their selectivity for cancer cells with limited toxicity for normal tissues. Increased expression of Protease Activated Receptor-1 (PAR-1) has been reported in different malignant cells. In this study we report that HAP induced activation and over expression of PAR-1 in breast cancer cells (EAC). Immunoprecipitation studies have shown that HAP specifically binds with PAR-1. HAP mediated activation of PAR-1 caused nuclear translocation of p50-p65 and the phosphorylation of p38 which triggered the activation of NFκB and MAP kinase signaling pathways. These signaling pathways enhanced the cellular ROS level in malignant cells that induced the intrinsic pathway of cell apoptosis. PAR-1 mediated apoptosis by HAP of malignant breast cells without effecting normal healthy cells in the same environment makes it a good therapeutic agent for treatment of cancer.

  13. "It was like reading a detective novel": Using PAR to work together for culture change.

    Science.gov (United States)

    Fortune, Darla; McKeown, Janet; Dupuis, Sherry; de Witt, Lorna

    2015-08-01

    Participatory action research (PAR), with its focus on engagement and collaboration, is uniquely suited to enhancing culture change initiatives in dementia care. Yet, there is limited literature of its application to culture change approaches in care settings, and even less in dementia specific care contexts. To address these gaps in the literature, the purpose of this paper is to examine the complexities of a PAR project aimed at changing the culture of dementia care in two diverse dementia care settings, including a long term care (LTC) and community care setting. Drawing from data gathered throughout the PAR process, we unpack the challenges experienced by participants working together to guide culture change within their respective care settings. These challenges include: overextending selves through culture change participation; fluctuating group membership; feeling uncertainty, confusion and apprehension about the process; frustratingly slow process; and seeking diverse group representation in decision making. We also highlight the potential for appreciative inquiry (AI) to be integrated with PAR to guide a process whereby participants involved in culture change initiatives can develop strategies to mitigate challenges they experience. We view the challenges and strategies shared here as being constructive to would-be culture change agents and hope this paper will move others to consider the use of PAR when engaging in culture change initiatives. Copyright © 2015 Elsevier Inc. All rights reserved.

  14. Lambeaux autofermants pour le traitement des brulures electriques du scalp par haut voltage

    Science.gov (United States)

    Hafidi, J.; El Mazouz, S.; El Mejatti, H.; Fejjal, N.; Gharib, N.E.; Abbassi, A.; Belmahi, A.M.

    2011-01-01

    Summary Les brûlures électriques par haut voltage sont responsables de gros dégâts tissulaires en immédiat et dans les jours suivant l’accident du fait de la chaleur importante dégagée par effet joule et de la thrombose microvasculaire évolutive. Les pertes de substances du scalp secondaires à ces brûlures nécessitent une couverture par lambeaux vu la destruction du périoste et du calvarium en regard. De juin 1997 à juin 2008, 15 patients ont été traités pour des pertes de substance du scalp secondaires à des brûlures électriques par haut voltage de diamètre allant de 8 à 11 cm et siégeant dans la région tonsurale. Ces patients ont été opérés dans la première semaine suivant l’accident. Les pertes de substance du scalp de taille moyenne secondaires à ces brûlures peuvent être couvertes per primam de façon fiable par des lambeaux locaux axialisés et multiples. Nous relatons l’expérience du Service de Chirurgie Plastique du Centre Hospitalier Universitaire Ibn-Sina, Rabat, Maroc, dans la gestion et la prise en charge de ces brûlures. PMID:22262963

  15. Public acceptance

    International Nuclear Information System (INIS)

    Bucaille, A.

    2006-01-01

    Full text of publication follows: A great deal of determination and professionalism are required when communicating to the public on nuclear energy. Challenging the advantages and adopting an educational tone are, of course, essential. But we have to do much more if we truly want to set people thinking and give nuclear energy its rightful position among the possible energy solutions. This is particularly important in Europe where dissension between countries is on the increase, whereas the US and China, shortly to be joined by India, have clearly decided to invest in nuclear energy. (author)

  16. Public health

    NARCIS (Netherlands)

    Berg, van den A.E.

    2007-01-01

    Agnes van den Berg wrote an essay about human health and nature, establishing that subject as an important policy argument in developing (urban) nature in the Netherlands. She studied the public balance of fear and fascination for nature, summarising benefits on human health. In this chapter, she

  17. Publication Design.

    Science.gov (United States)

    Nelson, Roy Paul

    This book is designed to solve the problem of coordinating art and typography with content in publications. Through text and illustrations, this book suggests ways to make pages and spreads in magazines, newspapers, and books attractive and readable. As a book of techniques, it is directed at potential and practicing art directors, designers, and…

  18. Tumour Microenvironments Induce Expression of Urokinase Plasminogen Activator Receptor (uPAR) and Concomitant Activation of Gelatinolytic Enzymes

    Science.gov (United States)

    Magnussen, Synnøve; Hadler-Olsen, Elin; Latysheva, Nadezhda; Pirila, Emma; Steigen, Sonja E.; Hanes, Robert; Salo, Tuula; Winberg, Jan-Olof; Uhlin-Hansen, Lars; Svineng, Gunbjørg

    2014-01-01

    Background The urokinase plasminogen activator receptor (uPAR) is associated with poor prognosis in oral squamous cell carcinoma (OSCC), and increased expression of uPAR is often found at the invasive tumour front. The aim of the current study was to elucidate the role of uPAR in invasion and metastasis of OSCC, and the effects of various tumour microenvironments in these processes. Furthermore, we wanted to study whether the cells’ expression level of uPAR affected the activity of gelatinolytic enzymes. Methods The Plaur gene was both overexpressed and knocked-down in the murine OSCC cell line AT84. Tongue and skin tumours were established in syngeneic mice, and cells were also studied in an ex vivo leiomyoma invasion model. Soluble factors derived from leiomyoma tissue, as well as purified extracellular matrix (ECM) proteins, were assessed for their ability to affect uPAR expression, glycosylation and cleavage. Activity of gelatinolytic enzymes in the tissues were assessed by in situ zymography. Results We found that increased levels of uPAR did not induce tumour invasion or metastasis. However, cells expressing low endogenous levels of uPAR in vitro up-regulated uPAR expression both in tongue, skin and leiomyoma tissue. Various ECM proteins had no effect on uPAR expression, while soluble factors originating from the leiomyoma tissue increased both the expression and glycosylation of uPAR, and possibly also affected the proteolytic processing of uPAR. Tumours with high levels of uPAR, as well as cells invading leiomyoma tissue with up-regulated uPAR expression, all displayed enhanced activity of gelatinolytic enzymes. Conclusions Although high levels of uPAR are not sufficient to induce invasion and metastasis, the activity of gelatinolytic enzymes was increased. Furthermore, several tumour microenvironments have the capacity to induce up-regulation of uPAR expression, and soluble factors in the tumour microenvironment may have an important role in the

  19. Tumour microenvironments induce expression of urokinase plasminogen activator receptor (uPAR and concomitant activation of gelatinolytic enzymes.

    Directory of Open Access Journals (Sweden)

    Synnøve Magnussen

    Full Text Available The urokinase plasminogen activator receptor (uPAR is associated with poor prognosis in oral squamous cell carcinoma (OSCC, and increased expression of uPAR is often found at the invasive tumour front. The aim of the current study was to elucidate the role of uPAR in invasion and metastasis of OSCC, and the effects of various tumour microenvironments in these processes. Furthermore, we wanted to study whether the cells' expression level of uPAR affected the activity of gelatinolytic enzymes.The Plaur gene was both overexpressed and knocked-down in the murine OSCC cell line AT84. Tongue and skin tumours were established in syngeneic mice, and cells were also studied in an ex vivo leiomyoma invasion model. Soluble factors derived from leiomyoma tissue, as well as purified extracellular matrix (ECM proteins, were assessed for their ability to affect uPAR expression, glycosylation and cleavage. Activity of gelatinolytic enzymes in the tissues were assessed by in situ zymography.We found that increased levels of uPAR did not induce tumour invasion or metastasis. However, cells expressing low endogenous levels of uPAR in vitro up-regulated uPAR expression both in tongue, skin and leiomyoma tissue. Various ECM proteins had no effect on uPAR expression, while soluble factors originating from the leiomyoma tissue increased both the expression and glycosylation of uPAR, and possibly also affected the proteolytic processing of uPAR. Tumours with high levels of uPAR, as well as cells invading leiomyoma tissue with up-regulated uPAR expression, all displayed enhanced activity of gelatinolytic enzymes.Although high levels of uPAR are not sufficient to induce invasion and metastasis, the activity of gelatinolytic enzymes was increased. Furthermore, several tumour microenvironments have the capacity to induce up-regulation of uPAR expression, and soluble factors in the tumour microenvironment may have an important role in the regulation of posttranslational

  20. Exit this way; Par ici la sortie du nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    This paper aims to inform the public on the nuclear power phaseout necessity. The fist part presents the hazards bound the nuclear activities, from the uranium mines to the radioactive wastes disposal and the reasons of a necessary phaseout. The second part recalls the historical aspects of the nuclear power implementation in the french energy policy and the today government attitude to value its choice. The last part presents the advantages of other energies sources and scenario of nuclear power phaseout. (A.L.B.)

  1. Teatro da Paz: histórias invisíveis em Belém do grão-Pará

    Directory of Open Access Journals (Sweden)

    Roseane Silveira de Souza

    2010-01-01

    Full Text Available Teatro da Paz ("Peace Theater", in Belém, capital of State of Pará, is one of the most representative neo-classical opera houses in brazil. Its remarkable history and features resulted of a deep process of architectonic renewal occurred between 1904 and 1905, when it had also a sort of rich elements of decoration incorporated. As a result, the process hidden facts happened from the building (1869-1878, following by the opening and functioning (1878-1887, until the first important renovation (1887-1890, involving improper management of public sources, conflicts between engineers, litigations, the intense public uses for nine years and the participation of two recognized artists, the Italian Domenico de Angelis and the brazilian Chrispim do Amaral, in the first renovation. Uncovering these invisible histories, outsider histories, give to monument back its human, social dimension.

  2. Evaluation of Passive Autocatalytic Recombiner (PAR) Implementation in a Konvoi NPP Containment Type

    Energy Technology Data Exchange (ETDEWEB)

    Lopez-Alonso, E.; Papini, D.; Jimenez, G.

    2015-07-01

    The evaluation of Passive Autocatalytic Recombiner (PAR) implementation has been developed under the methodology extracted from the IAEA document, analysing the size, location and number of the PARs capable to minimize the combustion risk, which arises from a hydrogen release generated during a severe accident and its distribution in containment building. A detailed three-dimensional model of Konvoi (PWR) containment with GOTHIC 8.1 code was used for the simulations. The hydrogen preferential pathways and the accumulation points were studied and identified on the basis of a base case scenario without any mitigation measure. The PAR configuration offers an improvement in the chosen accidental scenario; decreasing the possibility of hydrogen combustion and leading to concentration values below the flammability limit (hydrogen concentration below 7%), in all the containment compartments at the end of the transient. Furthermore, from the analysis, it is concluded that the time required to reach hydrogen concentrations below the combustion limit is considerably reduced. (Author)

  3. CRP and suPAR are differently related to anthropometry and subclinical organ damage

    DEFF Research Database (Denmark)

    Lyngbæk, Stig; Sehestedt, Thomas; Marott, Jacob L

    2013-01-01

    BACKGROUND: Low-grade inflammation is a marker for cardiovascular disease (CVD). The inflammatory biomarkers C-reactive protein (CRP) and soluble urokinase plasminogen activator receptor (suPAR) independently predict CVD. We tested the hypothesis that these biomarkers reflect different aspects...... of the inflammation associated with CVD. METHODS: We studied 2273 subjects without CVD. Log-transformed CRP and suPAR were included in general linear and logistic regression models to compare associations with measures of anthropometry and subclinical organ damage (SOD). Owing to interactions on body mass index (BMI......) (P3: 1.31 (1.16-1.47), whereas log-CRP was not (1.00 (0.89-1.11))). CONCLUSIONS: CRP is positively associated with anthropometric measures, whereas suPAR is linked to endothelial dysfunction and atherosclerosis....

  4. Potential Ecological Effects of Contaminants in the Exposed Par Pond Sediments

    International Nuclear Information System (INIS)

    Paller, M.H.; Wike, L.D.

    1996-08-01

    Sediment and small mammal samples were collected from the exposed sediments of Par Pond in early 1995, shortly before the reservoir was refilled after a 4-year drawdown. Sampling was confined to elevations between 58 and 61 meters (190 and 200 feet) above mean sea level, which includes the sediments likely to be exposed if the Par Pond water level is permitted to fluctuate naturally. Both soil and small mammal samples were analyzed for a number of radionuclides and metals. Some of the soil samples were also analyzed for organic contaminants. The objective of the study was to determine if contaminant levels in the Par Pond sediments were high enough to cause deleterious ecological effects

  5. Harmonization and development of resources and tools for Italian natural language processing within the PARLI project

    CERN Document Server

    Bosco, Cristina; Delmonte, Rodolfo; Moschitti, Alessandro; Simi, Maria

    2015-01-01

    The papers collected in this volume are selected as a sample of the progress in Natural Language Processing (NLP) performed within the Italian NLP community and especially attested by the PARLI project. PARLI (Portale per l’Accesso alle Risorse in Lingua Italiana) is a project partially funded by the Ministero Italiano per l’Università e la Ricerca (PRIN 2008) from 2008 to 2012 for monitoring and fostering the harmonic growth and coordination of the activities of Italian NLP. It was proposed by various teams of researchers working in Italian universities and research institutions. According to the spirit of the PARLI project, most of the resources and tools created within the project and here described are freely distributed and they did not terminate their life at the end of the project itself, hoping they could be a key factor in future development of computational linguistics.

  6. Effect of a physical activity intervention on suPAR levels

    DEFF Research Database (Denmark)

    Rohde, Christopher; Polcwiartek, Christoffer; Andersen, Eivind

    2018-01-01

    OBJECTIVES: Soluble urokinase-type plasminogen activator receptor (suPAR) is a novel inflammatory marker, associated with lifestyle diseases and mortality risk. No studies have investigated whether physical activity may reduce suPAR levels using a randomized controlled design. DESIGN AND METHODS......: suPAR and C-reactive protein (CRP) levels were determined in blood samples from a previous randomized controlled trial with Pakistani immigrants in Norway, 2008. The study included physically inactive men that were randomized to an intervention group (supervised group exercises) or a control group...... and followed for 5 months. A linear regression model was used and adjusted for age, inactivity level at baseline, and mean difference in CRP levels. RESULTS: Overall, 80 and 53 participants were included in the intervention and control group, respectively. Obesity and smoking were associated with higher su...

  7. Accouchement par césarienne et mortalité maternelle du postpartum

    OpenAIRE

    Deneux-Tharaux , Catherine; Carmona , Elodie; Bouvier-Colle , Marie-Hélène; Bréart , Gérard

    2006-01-01

    Objectifs Une augmentation continue du taux d'accouchements par césarienne (CS)est observée dans la plupart des pays depuis 20 ans. Cette évolution a suscité l'émergence d'un débat controversé sur les risques et les bénéfices associés à la CS. L'objectif de cette étude était d'estimer le risque de mort maternelle du postpartum lié directement à la CS par comparaison à l'accouchement par voie basse, globalement et en distinguant les CS pre- ou intra- partum . Méthode Etude cas/témoins. Les cas...

  8. Modification de la surface du cuivre par implantation ionique par source plasma (IISP): applications à l’érosion cathodique dans les systèmes à arcs

    OpenAIRE

    Roy, F

    2006-01-01

    L’érosion cathodique est un phénomène bien connu qui limite la durée de vie de l’électrode négative dans les systèmes à arcs. Dans le présent mémoire, nous avons tenté de voir si la formation de précipités nanométriques d’oxyde de cuivre pouvait réduire l’érosion cathodique nécessaire au maintien de l’arc en mode thermo-champ (T-F). Les dits précipités ont été produits par implantation ionique par source plasma (IISP). Avec l’aide de techniques de caractérisation telle que la microscopie à fo...

  9. Publications | CRDI - Centre de recherches pour le développement ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le CRDI collabore avec les chercheurs et les établissements des pays en développement au renforcement des capacités locales par le truchement du financement, de la mise en commun des connaissances et de la formation. Avec nos livres, nos articles, nos publications de recherche et nos études, nous visons à ...

  10. Comparison of Direct Pars Repair Techniques of Spondylolysis in Pediatric and Adolescent Patients: Pars Compression Screw Versus Pedicle Screw-Rod-Hook.

    Science.gov (United States)

    Karatas, Ali F; Dede, Ozgur; Atanda, Alfred A; Holmes, Larry; Rogers, Kenneth; Gabos, Peter; Shah, Suken A

    2016-08-01

    Retrospective clinical cohort study. To compare the clinical and radiographic outcomes of patients who were treated with intrasegmental pars fixation by either laminar compression screw (LS) or a pedicle screw, rod, and laminar hook (PSRH) construct. Spondylolysis is a nonunion defect of the pars interarticularis. In symptomatic spondylolysis, direct repair of the pars interarticularis defect can preserve motion and prevent abnormal stresses at the adjacent levels. Sixteen patients who failed nonoperative treatment and underwent direct pars repair by using LS (n=9) or PSRH (n=7) constructs were included in the study. Clinical outcome was assessed by using the MacNab criteria. Radiologic fusion and complications were evaluated using plain radiographs or computed tomography images and patient charts. The healing rate was 100% after 6 months. The healing time was similar in both the groups: LS, 6.5 months; PSRH, 6.2 months. Patients with PSRH (5.9 mo) were more likely to return to sports earlier relative to patients with LS (7.7 mo). There were no complications in the LS group; in the PSRH group, 1 patient had mild sensory deficit and 2 had superficial wound infections. The MacNab criteria for pain assessment showed an excellent or good outcome in 8 of 9 patients in LS group and 6 of 7 patients in PSRH group. Relative to LS patients, there was a significant increase in surgical time and estimated blood loss among PSRH patients. Either of the mentioned 2 techniques appears to produce acceptable results. Biplanar fluoroscopy and navigation systems could minimize the risk of screw misplacement with LS construct. Familiarity with the various fixation techniques will allow the surgeon to select the most appropriate surgical technique.

  11. First-in-human uPAR PET: Imaging of Cancer Aggressiveness

    Science.gov (United States)

    Persson, Morten; Skovgaard, Dorthe; Brandt-Larsen, Malene; Christensen, Camilla; Madsen, Jacob; Nielsen, Carsten H.; Thurison, Tine; Klausen, Thomas Levin; Holm, Søren; Loft, Annika; Berthelsen, Anne Kiil; Ploug, Michael; Pappot, Helle; Brasso, Klaus; Kroman, Niels; Højgaard, Liselotte; Kjaer, Andreas

    2015-01-01

    A first-in-human clinical trial with Positron Emission Tomography (PET) imaging of the urokinase-type plasminogen activator receptor (uPAR) in patients with breast, prostate and bladder cancer, is described. uPAR is expressed in many types of human cancers and the expression is predictive of invasion, metastasis and indicates poor prognosis. uPAR PET imaging therefore holds promise to be a new and innovative method for improved cancer diagnosis, staging and individual risk stratification. The uPAR specific peptide AE105 was conjugated to the macrocyclic chelator DOTA and labeled with 64Cu for targeted molecular imaging with PET. The safety, pharmacokinetic, biodistribution profile and radiation dosimetry after a single intravenous dose of 64Cu-DOTA-AE105 were assessed by serial PET and computed tomography (CT) in 4 prostate, 3 breast and 3 bladder cancer patients. Safety assessment with laboratory blood screening tests was performed before and after PET ligand injection. In a subgroup of the patients, the in vivo stability of our targeted PET ligand was determined in collected blood and urine. No adverse or clinically detectable side effects in any of the 10 patients were found. The ligand exhibited good in vivo stability and fast clearance from plasma and tissue compartments by renal excretion. In addition, high uptake in both primary tumor lesions and lymph node metastases was seen and paralleled high uPAR expression in excised tumor tissue. Overall, this first-in-human study therefore provides promising evidence for safe use of 64Cu-DOTA-AE105 for uPAR PET imaging in cancer patients. PMID:26516369

  12. Sucralfate modulates uPAR and EGFR expression in an experimental rat model of cervicitis.

    Science.gov (United States)

    Mannari, C; Santi, S; Migliori, M; Filippi, C; Origlia, N; Sansò, M; Boldrini, E; Giovannini, L

    2008-01-01

    Sucralfate is a drug used in the treatment of gastric and duodenal ulcer; it is cytoprotective and able to increase the bioavailability of several growth factors, modulating the wound healing process. In this study we tested the possible therapeutic effect of Sucralfate in the treatment of ulcerative lesions occurring in uterine cervix; to investigate such effect we used an experimental rat model of cervicitis in which the uPAR and EGFR expression were evaluated. Cervicitis was induced in wild and ovariectomized Wistar female rats by an acetic acid-soaked tampon. The animals were divided into two main groups (4 and 7 days) and Sucralfate was administered topically until the day they were sacrificed. In order to distinguish physiological and drug-induced healing, quantitative and qualitative uPAR and EGFR expression were evaluated by using Western blot and Immunohistochemistry techniques. Western blot analysis demonstrated an increased expression of both receptors after 4 days from wounding in wild and ovariectomized animals. In particular in ovariectomized animals the expression of uPAR and EGFR increased after 4 days while it reduced following the administration of Sucralfate. In wild rats the same was observed for uPAR expression, while EGFR was different; in fact, its expression increased significantly at day 4 in the animals treated with the drug and only at day 7 in those untreated. Immunohistochemistry highlighted a noteworthy epithelial colocalization of EGFR and uPAR after 4 days in the animals treated with Sucralfate. We conclude that Sucralfate can promote the healing of ulcerative cervicitis and moreover, it reduces the normal healing time because of its modulatory property on uPAR and EGFR expression.

  13. Proposition d'explication de la formation d'hydrogène sulfuré dans les stockages souterrains de gaz naturel par réduction des sulfures minéraux de la roche magasin Proposed Explanation of Hydrogen-Sulfide Formation in Underground Natural-Gas Storage Structures by Reduction of Mineral Sulfides in the Reservoir Rock.

    Directory of Open Access Journals (Sweden)

    Bourgeois J. P.

    2006-11-01

    Full Text Available La formation d'hydrogène sulfuré dans les structures de stockage peu expliquer autrement que par l'action de bactéries sulfato-réductrices. La contenue dans la roche magasin constitue une source de sulfures capable d'alimenter en H2S le gaz naturel. La réduction de la pyrite en sulfures du type Fe 1-x S et l'équilibre de dissolution précipitation, lié principalement à la pression de CO2, dans les structures stockages, constituent un processus de formation d'H2S capable d'expliquer tativement et quantitativement les phénomènes observés sur le terrain. Un modèle simplifié de stockage reprend ce schéma et teste la sensibililté de la teneur en H2S à la valeur des paramètres physiques et chimiques définissant le stockage. Cette étude permet de proposer un certain nombre d'actions susceptibles de limiter la formation d'H2S et d'orienter les choix futurs du couple gaz naturel - structures de stockage. The formation of hydrogen sulfide in storage structures can be explained otherwise thon by the action of sulfate-reducing bacteria. The pyrite contained in the reservoir rock makes up a source of sulfides capable of supplying the natural gas with H2S.Reduction of pyrite ta sulfides of the Fe,-,S type and the dissolution precipitation equilibrium, linked mainly ta C02 pressure in storage structures, make up an H2S for-mation process capable of qualitatively and quantitatively explained phenomena observed in the field.A simplified storage model reflects this scheme and can be used ta test the sensi-tivity of the H2S content ta the value of the physical and chemical parameters defining the storage structure.This investigation can be used to propose various means of action (sable ta "mit H2S formation and ta guide future choices of natural gas/storage-structure pairs.

  14. Protease activated receptors (PARS) mediation in gyroxin biological activity; Mediacao dos receptores ativados por proteases (PARs) em atividades biologicas da giroxina

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Jose Alberto Alves da

    2009-07-01

    Gyroxin is a serine protease enzyme from the South American rattlesnake (Crotalus durissus terrificus) venom; it is only partially characterized and has multiple activities. Gyroxin induces blood coagulation, blood pressure decrease and a neurotoxic behavior named barrel rotation. The mechanisms involved in this neurotoxic activity are not known. Whereas gyroxin is a member of enzymes with high potential to become a new drug with clinical applications such as thrombin, batroxobin, ancrod, tripsyn and kalicrein, it is important to find out how gyroxin works. The analysis on agarose gel electrophoresis and circular dichroism confirmed the molecules' integrity and purity. The gyroxin intravenous administration in mice proved its neurotoxicity (barrel rotation). In vivo studies employing intravital microscopy proved that gyroxin induces vasodilation with the participation of protease activated receptors (PARs), nitric oxide and Na+K+ATPase. The leukocytes' adherence and rolling counting indicated that gyroxin has no pro inflammatory activity. Gyroxin induced platelet aggregation, which was blocked by inhibitors of PAR1 and PAR4 receptors (SCH 79797 and tcY-NH{sub 2}, respectively). Finally, it was proved that the gyroxin temporarily alter the permeability of the blood brain barrier (BBB). Our study has shown that both the protease-activated receptors and nitric oxide are mediators involved in the biological activities of gyroxin. (author)

  15. Rat beta-LPH, gamma-LPH and beta-endorphin biosynthesized by isolated cells of pars intermedia and pars distalis

    International Nuclear Information System (INIS)

    Gianoulakis, C.; Seidah, N.G.; Routhier, R.; Chretien, M.

    1980-01-01

    Rats pars intermedia cells were incubated for 3 h with the following amino-acids: a) 35 S-methionine and 3 H-phenylalamine; b) 3 H-valine; and c) 3 H-valine and 3 H-lysine. Radioactive gamma-lipotropin, beta-lipotropin and beta-endorphin were purified on carboxy- methyl-cellulose and characterized by polyacrylamide disc gel electrophoresis af pH 4.5, molecular weight estimation and microsequencing. Rat gamma-lipotropin was shown to differ slightly from ovine gamma-lipotropin in its NH 2 -terminal amino acid sequence, in containing no methionine and having phenylalanine at position 6, valine at positions 13 and 27, and lysine at position 20. The same variations were observed in the sequence of rat beta-lipotropin, while rat beta-endorphin was shown to be identical to the ovine beta-endorphin. Following a 3-h pulse of rat pars distalis, the cells were extracted with care to avoid beta-lipotropin degradation by proteolytic enzymes. A peptide was purified and identified to be rat beta-endorphin, thus demonstrating that beta-endorphin is biosynthesized in pars distalis and is not an extraction artifact. (author)

  16. Eficacia de los antivirales en la parálisis de Bell

    OpenAIRE

    Vázquez, María Cristina; Sánchez, Nury; Calvo, Judith; Perna, Abayubá

    2008-01-01

    Introducción: la parálisis de Bell es una afección frecuente que presenta en 15% de los casos una recuperación incompleta. En los últimos años se ha acumulado evidencia del posible rol del virus herpes simple tipo 1 en su etiología. Objetivos: comparar la eficacia de valaciclovir y prednisona versus prednisona placebo en la parálisis de Bell. Material y método: se realizó un ensayo prospectivo, randomizado y placebo controlado. De los 41 pacientes incluidos, 21 fueron tratados con valaciclovi...

  17. evaluation de la fertilite femelle des arabusta par le niveau de ...

    African Journals Online (AJOL)

    Les hybrides Arabusta sont caractérisés par une faible fertilité exprimée par des taux de caracolis élevés et des taux de loges vides importants induisant des productivités faibles. Pour une stratégie plus efficiente des sélections, il est important de connaître les niveaux de fertilité femelle des différents types de caféiers ...

  18. Densité, morphologie urbaine et qualité de vie. Une approche par le projet

    OpenAIRE

    Occhiuto, Rita; Goossens, Marc; Fisher, Axel

    2013-01-01

    La recherche "Densification des tissus urbanisés en Wallonie: forme, acceptabilité et modalités pour accompagner la mutation des tissus bâtis" s'articule en plusieurs volets thématiques, parmi lesquels figure le volet "formes urbaines, modes d'habitat". Ce dernier volet est abordé selon deux approches parallèles et complémentaires qui se valident mutuellement: la première dite "par le projet" (approche qualitative et opérationnelle) et la seconde par analyse statistique et cartographique (ap...

  19. Situation des personnes transgenres par rapport au VIH/IST en Suisse : rapid assessment

    OpenAIRE

    Bize, R.; Koutaissoff, D.; Dubois-Arber, F.

    2013-01-01

    Ce rapport permet d'identifier le sous-groupe des personnes transgenres pratiquant ou ayant pratiqué le travail du sexe comme une population clairement exposée à un risque notoirement élevé d'infection par le VIH et les IST. L'ampleur rapportée du phénomène justifie pleinement l'inclusion de cette population dans le dispositif de surveillance comportementale du VIH et des autres IST, mais également la réalisation urgente d'actions de prévention communautaire. Par contre, il ne nous permet pas...

  20. L’influence d’innovations pédagogiques sur le profil motivationnel et le choix de stratégies d’apprentissage d’étudiantes et d’étudiants d’une faculté d’ingénierie

    Directory of Open Access Journals (Sweden)

    Anastassis Kozanitis

    2010-05-01

    Full Text Available L’étude vise à dégager une typologie des caractéristiques motivationnelles ainsi que des stratégies d’apprentissage utilisées par les étudiants en fonction de trois approches pédagogiques, soit l’exposé, l’approche par projet et l’apprentissage individualisé sur le web. Un questionnaire a été rempli par 494 étudiants du premier cycle universitaire. L’analyse des correspondances et de classification montre que ce sont l’approche par projet et l’exposé magistral qui suscitent le plus la motivation, alors que l’approche de l’apprentissage individualisée sur le web est celle qui en suscite le moins. L’approche individualisée et l’exposé magistral incitent davantage le recours aux stratégies de mémorisation, de répétition et d’organisation, alors qu’on a davantage recours aux stratégies de régulation de l’effort et de gestion du temps dans les cours-projets. Une discussion tente d’expliquer les différences observées.The study’s aim is to establish a classification of motivational characteristics and learning strategies used by students within three different instructional approaches : lectures, project based-instruction, and web-based instruction. A self-report questionnaire was administered to 494 undergraduates. Results of the cluster analyses reveal that students attending project-based instruction and lecture method show higher levels of motivation than those attending web-based instruction. Students in lecture method and web-based instruction turn more often to memorisation, revision and organisation strategies, while project-based learning promotes the use of effort and time regulation strategies. A discussion seeks to explain the observed differences.

  1. Public meetings

    CERN Multimedia

    Staff Association

    2012-01-01

    MARS PENSIONS CONTRACT POLICY GENERAL INFORMATION   PUBLIC MEETINGS COME AND BE INFORMED! Public meetings Monday 15 Oct. 2 pm Amphi IT, 31-3-004 Meyrin Wednesday 17 Oct. 10 am Amphi BE, 864-1-D02 Prévessin Thursday 18 Oct. 10 am Salle du Conseil/ Council Chamber 503-1-001 Meyrin Thursday 18 Oct. 2 pm Filtration Plant, 222-R-001(in English) Meyrin   Overview of the topics to be discussed Recognition of Merit – MARS Outcome of last exercise 2007 to 2012 : lessons learned Pension Fund Capital preservation policy : what is it ? Contract policy LC2IC statistics SA proposal General information CVI 2013 Voluntary programmes (PRP, SLS)  

  2. Publications, 1977

    International Nuclear Information System (INIS)

    Hilborn, H.S.

    1978-02-01

    A compilation of documents that communicate the results of scientific and technical work done at Savannah River is given. The compilation includes those documents that have been published (research and development reports, journal articles, book chapters, etc.), documents that have been announced in Energy Research Abstracts, and papers that have been presented at technical meetings but have not yet been published or announced. The information was compiled by machine methods to produce bibliographic, subject, and author listings. This report updates the information included in DP-929, Rev. 2, Publications, 1951 through 1971 and DP-929-1, Publications, 1972 through 1976. The bibliographic listing is arranged alphabetically by the first-mentioned author of each document. Author and subject indexes are provided

  3. Public relations

    International Nuclear Information System (INIS)

    1996-01-01

    At Nuclear Regulatory Authority of the Slovak Republic (NRA SR), the public relations belongs to the secretariat of the Chairman, and are a part of the policy of carefully planned and purposeful efforts to establish mutual relations between the authority and the public. A spokesmen of NRA SR is in charge of the public relations. The spokesman is ready, without a useless filibuster and based on a particular requirement, to inform governmental bodies, other national bodies and organizations, embassies and international organizations, the public and news media in case of an event at a nuclear installation. To provide for communications activities, NRA SR constructed and opened the Information centre with a particular equipment in autumn 1995, that has already started communications with some dailies, broadcasting, television and Press Agency SR. It has been envisaged that there will be press conferences held in the Information centre a few times a year, or NRA SR senior staff may be interviewed here on extraordinary events at NPPs, or on some other important occasions in NRA SR. In 1995, NRA Sr issued the Annual report in a few variants - each suitable for different use - on NRA SR activities and nuclear safety of Slovak nuclear power plants as of 1994. The NRA SR's Bulletin has started to be published with periodicity of 3 times a year, focusing on NRA SR activities both in Slovakia and abroad. NRA SR Information centre provides foreign visitors with independent propagation and information materials about the issue of nuclear safety enhancement at operational Slovak NPPs. Furthermore, the Information centre provides both the NRA SR's residences in Bratislava and Trnava with daily press monitoring of topical news

  4. Experimental study about the regulating effect of Par-4 gene overexpression on the nephroblastoma sensitivity to cisplatin

    Directory of Open Access Journals (Sweden)

    Hui-Lin Mao

    2017-11-01

    Full Text Available Objective: To study the regulating effect of Par-4 gene overexpression on the nephroblastoma sensitivity to cisplatin. Methods: Nephroblastoma SK-NEP-1 cells were cultured and divided into four groups, control group were treated with RMPI-1640 without serum or drugs, cisplatin group were treated with serum-free RMPI-1640 containing 5 μg/mL cisplatin, Par-4 group were transfected by Par-4 overexpression plasmids with serum-free RMPI-1640, and cisplatin + Par-4 group were transfected by Par-4 overexpression plasmid with serum-free RMPI-1640 containing 5 μg/mL cisplatin. The cell proliferation activity as well the expression of apoptosis genes, migration genes and invasion genes was measured. Results: 8 h, 16 h and 24 h after different conditions of treatment, the cell proliferation activity of cisplatin group, Par-4 group and cisplatin + Par-4 group were significantly lower than that of control group, and the cell proliferation activity of cisplatin + Par-4 group was significantly lower than that of cisplatin group and Par-4 group; 24 h after different conditions of treatment, Bim, PDCD4, WT1, RGS4, Axin, KAI1, E-cadherin, PPARγ and PTEN mRNA expression in cisplatin group, Par-4 group and cisplatin + Par-4 group were greatly higher than those in control group whereas GDNF, GFRα1, TUBB3, NME1 and FGF1 mRNA expression were greatly lower than those in control group; Bim, PDCD4, WT1, RGS4, Axin, KAI1, E-cadherin, PPARγ and PTEN mRNA expression in cisplatin + Par-4 group were greatly higher than those in cisplatin group and Par-4 group whereas GDNF, GFRα1, TUBB3, NME1 and FGF1 mRNA expression were greatly significantly lower than those in cisplatin group and Par-4 group. Conclusion: Par-4 gene overexpression can increase the nephroblastoma sensitivity to cisplatin, reduce cell proliferation activity, promote apoptosis and inhibit cell migration and invasion.

  5. Planar Cell Polarity Breaks the Symmetry of PAR Protein Distribution prior to Mitosis in Drosophila Sensory Organ Precursor Cells.

    Science.gov (United States)

    Besson, Charlotte; Bernard, Fred; Corson, Francis; Rouault, Hervé; Reynaud, Elodie; Keder, Alyona; Mazouni, Khalil; Schweisguth, François

    2015-04-20

    During development, cell-fate diversity can result from the unequal segregation of fate determinants at mitosis. Polarization of the mother cell is essential for asymmetric cell division (ACD). It often involves the formation of a cortical domain containing the PAR complex proteins Par3, Par6, and atypical protein kinase C (aPKC). In the fly notum, sensory organ precursor cells (SOPs) divide asymmetrically within the plane of the epithelium and along the body axis to generate two distinct cells. Fate asymmetry depends on the asymmetric localization of the PAR complex. In the absence of planar cell polarity (PCP), SOPs divide with a random planar orientation but still asymmetrically, showing that PCP is dispensable for PAR asymmetry at mitosis. To study when and how the PAR complex localizes asymmetrically, we have used a quantitative imaging approach to measure the planar polarization of the proteins Bazooka (Baz, fly Par3), Par6, and aPKC in living pupae. By using imaging of functional GFP-tagged proteins with image processing and computational modeling, we find that Baz, Par6, and aPKC become planar polarized prior to mitosis in a manner independent of the AuroraA kinase and that PCP is required for the planar polarization of Baz, Par6, and aPKC during interphase. This indicates that a "mitosis rescue" mechanism establishes asymmetry at mitosis in PCP mutants. This study therefore identifies PCP as the initial symmetry-breaking signal for the planar polarization of PAR proteins in asymmetrically dividing SOPs. Copyright © 2015 Elsevier Ltd. All rights reserved.

  6. Les perspectives nutritionnelles offertes par les OGM en alimentation humaine

    Directory of Open Access Journals (Sweden)

    Pascal Gérard

    2004-03-01

    Full Text Available Une étude des brevets récents, des publications scientifiques ainsi que des documents présentant les projets des firmes de biotechnologie constituent la base de cet article qui présente les perspectives de développement en alimentation humaine des organismes génétiquement modifiés (OGM présentant un intérêt nutritionnel. Si l’on trouve dans les brevets et les publications scientifiques des applications qui concernent l’amélioration ou l’enrichissement de la composition en macro- et micronutriments, ces applications restent curieusement à l’état de projets, très loin de la mise sur le marché. Les critiques aussi bien que les louanges dont sont l’objet les rares cas dont on pourrait envisager une mise en œuvre à moyen terme, comme le « riz doré », sont aussi injustifiées et excessives les unes que les autres. Les violentes polémiques autour des OGM risquent de handicaper le développement d’une technique puissante, qui n’est certes pas indispensable pour apporter une solution à l’éradication de la faim dans le monde, mais qui peut apporter des améliorations à la nutrition des populations, aussi bien des populations des pays en développement que des pays développés.

  7. Equações de chuvas intensas para o estado do Pará Intense rainfall equations for the state of Pará, Brazil

    Directory of Open Access Journals (Sweden)

    Rodrigo O. R. de M. Souza

    2012-09-01

    Full Text Available As equações de chuvas intensas têm sido usadas como ferramenta importante para o dimensionamento de obras hidráulicas. Devido à grande carência de informações relativas às equações de chuvas intensas, o presente trabalho teve como objetivo a obtenção das relações de intensidade, duração e frequência de precipitação pluvial para o Estado do Pará, utilizando-se a metodologia da desagregação da chuva de 24 h. Foram utilizadas séries históricas de dados pluviométricos de 74 cidades do Estado do Pará, obtidas no Sistema de Informações Hidrológicas da Agência Nacional de Águas-ANA. As equações de intensidade-duração-frequência foram devidamente ajustadas e apresentaram bom ajuste, com coeficientes de determinação acima de 0,99. A maioria das estações (51,4% apresentou intensidade de precipitação entre 90 e 110 mm h-1, para uma duração de chuva de 30 min e um tempo de retorno de 15 anos. Pode-se perceber uma concentração das maiores precipitações na região próxima ao litoral do nordeste paraense e no sudeste da Ilha do Marajó.The intense rainfall equations have been used as an important tool for design of hydraulic structures. Considering the lack of intense rainfall equations, this study aimed to determine the relations of intensity, duration and frequency of intense rainfall in the Pará State (Brazil, using the one-day rain disaggregation method. In this research rainfall data of 74 cities in the State of Pará were used, obtained from the Hydrological Information System of the National Water Agency-ANA. The equations of intensity-duration-frequency were adjusted and presented good adjustment with coefficients of determination above 0.99. Most stations (51.4% showed intensity of precipitation between 90 and 110 mm h-1 for duration of 30 min and rainfall return period of 15 years. The highest rainfall intensities were in the region near the northeast coast of Pará State and southeast of the Marajo

  8. Dinâmica socioambiental na Vila dos Pescadores (Amazônia Oriental, Pará, Brasil

    Directory of Open Access Journals (Sweden)

    Luci Cajueiro Carneiro Pereira

    2006-01-01

    Full Text Available This study describes the social, economic and environmental aspects of a fishing community “Vila dos Pescadores” situated in the Caeté River Estuary, northeastern Pará (Brazil. The methodology adopted in this study was based on interviews, questionnaires and direct observations to characterize some social, economic and environmental aspects and on monitored of beach profile to know the local coastal dynamic. Results show that the majority of the interviewed are between 18-35 years (50.97%, are fishermen (62.13%, married (68.93%, with elementary school not completed (77.67%, live with the family (2-4 persons, 39.85% in their own houses (86.89% and earn monthly less than one salary (95.63%. The majority of the people has been living in the village for 10 years or more (42.71% and do not like their current social, economic and environmental situation. The village has someenvironmental problems such as coastal erosion and serious service and infrastructure problems (e.g. little or total absence of public transports, public telephones, garbage collectors, public illumination, drinking water, basic sanitary facilities, underdeveloped commercial area, sport area, health post, police post, car parking, lifeguard, school, among others. The absence of employment opportunities is another problem, being the fisheries the main source of income in the village. On the other hand, the exuberant nature, the equatorial weather, the tranquility and the large amount of fish are the main positive aspects according to the opinion of those interviewed.

  9. écrivain-e. Par-delà le genre – par-delà le corps ?

    Directory of Open Access Journals (Sweden)

    Cécile Chamayou-Kuhn

    2009-12-01

    Full Text Available Cet article propose d’étudier la relation qu’entretiennent, d’une part, le langage et le corps et, d’autre part, la parole et l’identité sexuelle dans Die Kränkung d’Evelyn Schlag et Der Tod und das Mädchen : III (Rosamunde ; V (Die Wand d’Elfriede Jelinek. Malgré les divergences de ton que présentent ces oeuvres, qui appartiennent à deux genres littéraires différents, il semble permis de centrer l’analyse sur une problématique commune : le personnage de « l’écrivain-e » parvient-il à saisir son propre corps ? Dans cette perspective, nous nous appuyons sur la critique formulée par Judith Butler à l’égard de la psychanalyse lacanienne, tout en considérant sa théorie sur la construction discursive du corps. Trois thématiques peuvent être développées : la dialectique de « l’in-visibilité » féminine, les processus de matérialisation du corps et la pratique subversive de la mascarade en tant qu’elle met en évidence certains mécanismes d’aliénation dans le cadre d’une genèse du corps et de l’écriture. Aussi peut-on affirmer que le drame du corps investi symboliquement sous-tend ces œuvres : l’écrivain-e tente de s’extraire de l’ordre symbolique et de saper les fondements des catégories constitutives de l’identité que sont le désir, le sexe biologique (sex et l’identité sexuelle (gender. Si les processus d’écriture laissent envisager un dépassement de l’offense narcissique et de la maladie dans Die Kränkung, un tel dénouement paraît exclu dans l’univers jelinekien : ses « héroïnes », qui évoluent comme autant de fantômes du signifiant, entament une éternelle danse de mort.Untersucht wird im folgenden Artikel – anhand der Texte Die Kränkung von Evelyn Schlag und Der Tod und das Mädchen III (Rosamunde und V (Die Wand von Elfriede Jelinek – das Verhältnis von Sprache zum Körper sowie die Beziehung zwischen Sprechen und

  10. Growth-Maximizing Public Debt under Changing Demographics

    DEFF Research Database (Denmark)

    Bokan, Nikola; Hougaard Jensen, Svend E.; Hallett, Andrew Hughes

    2016-01-01

    This paper develops an overlapping-generations model to study the growth-maximizing level of public debt under conditions of demograhic change. It is shown that the optimal debt level depends on a positive marginal productivity of public capital. In general, it also depends on the demographic par...... will have to adjust its fiscal plans to accommodate those changes, most likely downward, if growth is to be preserved. An advantage of this model is that it allows us to determine in advance the way in which fiscal policies need to adjust as demographic parameters change....

  11. How Public Is Public Administration? A Constitutional Approach of Publicness

    Science.gov (United States)

    Ringeling, Arthur

    2015-01-01

    Both in Public Administration and in practice, there is a loss of the concept of public. A view became dominant in which markets were superior to governments and public to private. Not only did the esteem of the public sphere diminish, but also its significance in our reasoning and teaching. It became less clear what the public sphere stood for.…

  12. Public relations as public information

    Energy Technology Data Exchange (ETDEWEB)

    Coninx, C.

    1983-01-01

    To the man in the street, the topic of nuclear energy on the one hand is a highly emotional subject incorporating dangers hard to assess. However, on the other hand, there is in most cases little inclination to concern oneself with problems of energy economy. Public relations activities therefore frequently must motivate their adresses to accept information before they can actually inform. In this connection, the informing party must appear trustworthy and avoid that a teacher : pupil relationship is created. In addition, the changes in the socio-political environment must be taken into account. Within the industries and organizations engaged in the nuclear field there is the problem that the effects and the impact of public relations work can hardly be gaged by individually, which greatly hampers quantification of the work actually done.

  13. Urokinase-type plasminogen activator receptor (uPAR), tissue factor (TF) and epidermal growth factor receptor (EGFR)

    DEFF Research Database (Denmark)

    Christensen, Anders; Kiss, Katalin; Lelkaitis, Giedrius

    2017-01-01

    Background: Tumor-specific biomarkers are a prerequisite for the development of targeted imaging and therapy in oral squamous cell carcinoma (OSCC). urokinase-type Plasminogen Activator Receptor (uPAR), Tissue Factor (TF) and Epidermal Growth Factor Receptor (EGFR) are three biomarkers that exhib...... with a reduced survival. uPAR seems to be a prognostic biomarker in oral cancer....

  14. Usefulness of suPAR as a biological marker in patients with systemic inflammation or infection: a systematic review

    NARCIS (Netherlands)

    Backes, Yara; van der Sluijs, Koenraad F.; Mackie, David P.; Tacke, Frank; Koch, Alexander; Tenhunen, Jyrki J.; Schultz, Marcus J.

    2012-01-01

    Systemic levels of soluble urokinase-type plasminogen activator receptor (suPAR) positively correlate with the activation level of the immune system. We reviewed the usefulness of systemic levels of suPAR in the care of critically ill patients with sepsis, SIRS, and bacteremia, focusing on its

  15. Manufactering of par-fried french-fries. Part 3: a blueprint to predict the maximum production yield

    NARCIS (Netherlands)

    Somsen, D.J.; Capelle, A.; Tramper, J.

    2004-01-01

    Very little research on the production yield of par-fried French-fries has been reported in the literature. This paper bridges the knowledge gap and outlines the development of a model to predict the maximum production yield of par-fried French-fries. This yield model can be used to calculate the

  16. L'initiative Agua Limpia para Perú est dirigée par un ancien titulaire ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    9 juil. 2014 ... Au Pérou, de nombreuses sources d'eau sont contaminées par de ... l'accès à une eau propre et la formation sur l'assainissement, les eaux usées et les ... par AguaSAN Perú aux fins du traitement des eaux (en espagnol).

  17. Public relations

    International Nuclear Information System (INIS)

    1998-01-01

    The Nuclear Regulatory Authority of the Slovak Republic (NRA SR) laid the foundation of a policy of keeping the public informed about the activities and the safety of nuclear installations in the SR already in its origins by opening the NRA Information Centre. The NRA SR issues the Bulletin on NRA SR for domestic and foreign use, the bilingual Annual report on NRA activities for domestic and foreign public - detailed report for the specialists and a version for the Slovak Republic state authorities. On the occasion of the anniversary of the IAEA a special publication on the IAEA was prepared. Forty-nine contributions on NRA national and foreign activities were trans-missed to the Press Agency of the SR (TASR) over the course of 1997. In the journal Safety of Nuclear Energy the column 'Information' periodically carries the briefs on NRA activities. Four essential articles on NRA mission and responsibility in the are of peaceful uses of atomic energy were published in the Newsletter of the Slovak Information Agency (SIA). Contributions on NRA activities and international co-operation are periodically put out in the 'Slovenske elektrarne' Newsletter, the Slovak Nuclear Society Bulletin. Report on the Safety of NPPs in the Slovak Republic is annually published in the Journal European Nuclear Society - Nuclear Europe Worldscan. Some articles on NRA activities were published in the world information agency NucNet. The NRA issued in 1997 four editions of the internal Bulletin on the NRA's national and foreign activities and personnel. Three press conferences were held and six events were arranged in radio broadcasting in 1997

  18. Public meetings

    CERN Multimedia

    Staff Association

    2014-01-01

      Public meetings : Come and talk about your future employment conditions !   The Staff Association will come and present the results of our survey on the 2015 five-yearly review. Following the survey, the topics discussed, will be contract policy, recognition of merit (MARS), working time arrangements and family policy. After each meeting and around a cup of coffee or tea you will be able to continue the discussions. Do not hesitate to join us, the five-yearly review, it is with YOU!

  19. Public meetings

    CERN Multimedia

    Staff Association

    2014-01-01

      MARS 2015 FIVE YEARLY REVIEW CONTRACT POLICY PENSION FUND GENERAL INFORMATION   COME AND BE INFORMED! PUBLIC MEETINGS Friday 3rd October at 10 am Amphi BE, 864-1-D02 Prévessin Friday 3rd October at 2 pm Salle du Conseil / Council Chamber, 503-1-001 (in English) Meyrin Monday 6th October at 10 am Kjell Johnsen Auditorium, 30-7-018 Meyrin Monday 6th October at 2 pm Salle du Conseil / Council Chamber, 503-1-001 Meyrin  

  20. e-Fès : Services publics en ligne | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    27 oct. 2010 ... Le projet de recherche-action e-Fès visait principalement à améliorer les services publics. Ce faisant, il a également renforcé la responsabilité du secteur public et favorisé l'esprit de démocratie au Maroc. De telles réalisations ont valu à ce projet — financé par le Centre de recherches pour le ...

  1. CALiPER Report 20.3: Robustness of LED PAR38 Lamps

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2014-12-30

    A small sample of each of the CALiPER Application Summary Report 20 PAR38 lamp types underwent stress testing that included substantial temperature and humidity changes, electrical variation, and vibration. The results do not directly address expected lifetime, but can be compared with one another, as well as with benchmark conventional products, to assess the relative robustness of the product designs.

  2. The rate of endophthalmitis after pars plana vitrectomy and its risk factors.

    Science.gov (United States)

    Tabatabaei, Seyed Ali; Soleimani, Mohammad; Vakili, Hadi; Naderan, Morteza; Lashay, Alireza; Faghihi, Houshang; Yaseri, Mehdi

    2018-05-11

    To study the incidence of endophthalmitis after pars plana vitrectomy, its causative organisms, and visual acuity outcomes. In this retrospective, comparative study, the medical records of patients with acute-onset postoperative endophthalmitis after pars plana vitrectomy at Farabi Eye Hospital, Tehran, Iran, during a 12-year period between January 2004 and November 2015 were reviewed. To compare the endophthalmitis patients with other cases who underwent pars plana vitrectomy at the same day and also the same operating room, a control group was developed by gathering the data from surgical records. In the present study, the incidence rate of pos- vitrectomy endophthalmitis was 0.04% (16/39783). The organisms identified in aqueous or vitreous cultures (culture positive 44%) included Streptococcus pneumoniae (two patients, 12.5%), Pseudomonas aeruginosa (two patients, 12.5%), fungi (two patients, 12.5%), and Streptococcus viridans (one patient, 6.25%). Visual acuity after treatment for endophthalmitis ranged from light perception (7 eyes) to hand motion (1 eye), and evisceration was performed in 8 eyes (50%). When comparing the cases (patients developing endophthalmitis) and controls (patients with no complications operated in the same day and place of operation with the case group), only not using tamponade showed a statistically significant relation with the occurrence of endophthalmitis (p = 0.034). Our results indicated low incidence of endophthalmitis after pars plana vitrectomy comparable to previous studies which resulted in poor visual acuity. It seems that not using tamponade might increase the risk of endophthalmitis among these patients.

  3. A Single-Cell Biochemistry Approach Reveals PAR Complex Dynamics during Cell Polarization.

    Science.gov (United States)

    Dickinson, Daniel J; Schwager, Francoise; Pintard, Lionel; Gotta, Monica; Goldstein, Bob

    2017-08-21

    Regulated protein-protein interactions are critical for cell signaling, differentiation, and development. For the study of dynamic regulation of protein interactions in vivo, there is a need for techniques that can yield time-resolved information and probe multiple protein binding partners simultaneously, using small amounts of starting material. Here we describe a single-cell protein interaction assay. Single-cell lysates are generated at defined time points and analyzed using single-molecule pull-down, yielding information about dynamic protein complex regulation in vivo. We established the utility of this approach by studying PAR polarity proteins, which mediate polarization of many animal cell types. We uncovered striking regulation of PAR complex composition and stoichiometry during Caenorhabditis elegans zygote polarization, which takes place in less than 20 min. PAR complex dynamics are linked to the cell cycle by Polo-like kinase 1 and govern the movement of PAR proteins to establish polarity. Our results demonstrate an approach to study dynamic biochemical events in vivo. Copyright © 2017 Elsevier Inc. All rights reserved.

  4. Par@Graph - a parallel toolbox for the construction and analysis of large complex climate networks

    NARCIS (Netherlands)

    Tantet, A.J.J.

    2015-01-01

    In this paper, we present Par@Graph, a software toolbox to reconstruct and analyze complex climate networks having a large number of nodes (up to at least 106) and edges (up to at least 1012). The key innovation is an efficient set of parallel software tools designed to leverage the inherited hybrid

  5. Identificación de parásitos gastrointestinales en aves silvestres en cautiverio

    OpenAIRE

    García Corredor, Diego José; Sánchez Parada, Oscar Javier; Pulido Medellín, Martin Orlando; Andrade Becerra, Roy José

    2013-01-01

    Este trabajo identifica los parásitos gastrointestinales que presentaron las aves silvestres en cautiverio, en el municipio de Tibasosa (Boyacá, Colombia). Se tomaron 100 muestras de materia fecal de aves silvestres correspondientes a 11 familias (Psittacidae, Ramphastidae, Ophistocomidae, Cracidae, Anatidae, Icteridae, Alaudidae, Burhinidae, Phoenicopteridae, Anhimidae y Rallidae) y 16 especies (Ara ararauna, Ara macao, Amazona spp, Amazona ochrocephala, Ramphastos toco,...

  6. UTILITY OF A WIDE SPECTRUM LIGHT METER AS AN UNDERWATER SENSOR OF PHOTOSYNTHETICALLY ACTIVE RADIATION (PAR)

    Science.gov (United States)

    The strong attenuation of infra red wavelengths (>700 nm) in coastal waters is suggestive that some instruments with broad spectral responses might be useful, inexpensive substitutes for PAR sensors in studies of estuarine plant dynamics. Wide spectrum (350-1100 nm) light intensi...

  7. Nanomechanical recognition of prognostic biomarker suPAR with DVD-ROM optical technology

    DEFF Research Database (Denmark)

    Bache, Michael; Bosco, Filippo; Brøgger, Anna Line

    2013-01-01

    In this work the use of a high-throughput nanomechanical detection system based on a DVD-ROM optical drive and cantilever sensors is presented for the detection of urokinase plasminogen activator receptor inflammatory biomarker (uPAR). Several large scale studies have linked elevated levels...

  8. Jesus en geweld: Markus 12:1-12 (en par) en Thomas 65 | van Eck ...

    African Journals Online (AJOL)

    Jesus and violence: Mark 12:1-12 (and par) and. Thomas 65. As an advanced agrarian (aristocratic) society, first-century Palestine's social fabric was built on systemic tensions and conflicts between the elite (rulers) and the peasantry (the ruled). At the root of these conflicts were incompatible values (ideologies) and

  9. Les politiques de développement élaborées par la Banque ...

    African Journals Online (AJOL)

    constamment de stratégies et de politiques de développement. De théorie en ..... supérieurs, un laxisme dans les règles de recrutement et une insuffisance de ... Par ailleurs, souligne la Banque mondiale (1980), la plupart des entreprises.

  10. uPAR EXPRESSION IN CANINE NORMAL PROSTATE AND WITH PROLIFERATIVE DISORDERS

    Directory of Open Access Journals (Sweden)

    Mariana Rodrigues Faleiro

    2013-06-01

    Full Text Available Prostatic lesions such as prostatic intraepithelial neoplasia (PIN and proliferative inflammatory atrophy (PIA are studied in human and canine species due to their malignance potential. The plasminogen activator (PA system has been suggested to play a central role in cell adhesion, angiogenesis, inflammation, and tumor invasion. The urokinase-type plasminogen activator receptor (uPAR is a component of the PA, with a range of expression in tumor and stromal cells. In this study, uPAR expression in both canine normal prostates and with proliferative disorders (benign prostatic hyperplasia-BPH, proliferative inflammatory atrophy-PIA, prostatic intraepithelial neoplasia-PIN, and carcinoma-PC was evaluated by immunohistochemistry in a tissue microarray (TMA slide to establish the role of this enzyme in extracellular matrix (ECM remodeling and in the processes of tissue invasion. A total of 298 cores and 355 diagnoses were obtained, with 36 (10.1% normal prostates, 46 (13.0% with BPH, 128 (36.1% with PIA, 74 (20.8% with PIN and 71 (20.0% with PC. There is variation in the expression of uPAR in canine prostate according to the lesion, with lower expression in normal tissue and with BPH, and higher expression in tissue with PIA, PIN and PC. The high expression of uPAR in inflammatory and neoplastic microenvironment indicates increased proteolytic activity in canine prostates with PIA, PIN, and PC.

  11. 27 Segmentation par logique floue pour l'estimation du nombre de ...

    African Journals Online (AJOL)

    bagui kossan olivier

    Le diagnostic rapide est par conséquent, une urgence médicale car, le ... Vision Allied Technology, avec un capteur de MT9P031 de Micron / Aptina), avec ..... [4] - O. K. BAGUI, J. T. ZOUEU, C. WÄHLBY, Automatic malaria diagnosis by the ...

  12. La bio-indication de la pollution aquatique par les microalgues (Cas ...

    African Journals Online (AJOL)

    ecosystCmes et introduisent des micro- organismes pathogmes qui ... organismes vivants dont on connait la sensibilite et les exigences ..... En effet, certains genres proliferent dans des milieux acides, alors que d'autres preferent des milieux alcalins. Par ailleurs, dans les milieux a fortes teneurs en elements acides tel que ...

  13. Rupture Uterine Par Accident De La Voie Publique: A propos d'un cas.

    African Journals Online (AJOL)

    Abstract. Un cas de rupture utérine par accident de la voie publique associée à une fracture de l'humérus droit et du bassin est décrit. Les pronostics maternels et foetal sont discutés à la lumière de la revue de la littérature.

  14. Evaluation de la Qualité de surface par la Dimension Fractale et les ...

    African Journals Online (AJOL)

    Evaluation of surface quality by Fractal Dimension and Volume. Parameters .... du microscope électronique à balayage la. FEG.SUPRA 40. ... telle configuration le rapport (L/Dp), est tel que : L0 ,75 ..... du contrôle par la dimension fractale ;.

  15. Dual Role of Host Par2 in a Murine Model of Spontaneous Metastatic B16 Melanoma

    Czech Academy of Sciences Publication Activity Database

    Olejár, Tomáš; Větvička, D.; Zadinová, M.; Poučková, P.; Kukal, J.; Ježek, Petr; Matěj, R.

    2014-01-01

    Roč. 34, č. 7 (2014), s. 3511-3515 ISSN 0250-7005 R&D Projects: GA ČR(CZ) GAP302/10/0346 Institutional support: RVO:67985823 Keywords : PAR2 * melanoma * metastasis * murine model Subject RIV: EA - Cell Biology Impact factor: 1.826, year: 2014

  16. PAR-Complex and Crumbs Function During Photoreceptor Morphogenesis and Retinal Degeneration.

    Science.gov (United States)

    Pichaud, Franck

    2018-01-01

    The fly photoreceptor has long been used as a model to study sensory neuron morphogenesis and retinal degeneration. In particular, elucidating how these cells are built continues to help further our understanding of the mechanisms of polarized cell morphogenesis, intracellular trafficking and the causes of human retinal pathologies. The conserved PAR complex, which in flies consists of Cdc42-PAR6-aPKC-Bazooka, and the transmembrane protein Crumbs (Crb) are key players during photoreceptor morphogenesis. While the PAR complex regulates polarity in many cell types, Crb function in polarity is relatively specific to epithelial cells. Together Cdc42-PAR6-aPKC-Bazooka and Crb orchestrate the differentiation of the photoreceptor apical membrane (AM) and zonula adherens (ZA) , thus allowing these cells to assemble into a neuro-epithelial lattice. In addition to its function in epithelial polarity, Crb has also been shown to protect fly photoreceptors from light-induced degeneration, a process linked to Rhodopsin expression and trafficking. Remarkably, mutations in the human Crumbs1 (CRB1) gene lead to retinal degeneration, making the fly photoreceptor a powerful disease model system.

  17. PAR-Complex and Crumbs Function During Photoreceptor Morphogenesis and Retinal Degeneration

    Directory of Open Access Journals (Sweden)

    Franck Pichaud

    2018-03-01

    Full Text Available The fly photoreceptor has long been used as a model to study sensory neuron morphogenesis and retinal degeneration. In particular, elucidating how these cells are built continues to help further our understanding of the mechanisms of polarized cell morphogenesis, intracellular trafficking and the causes of human retinal pathologies. The conserved PAR complex, which in flies consists of Cdc42-PAR6-aPKC-Bazooka, and the transmembrane protein Crumbs (Crb are key players during photoreceptor morphogenesis. While the PAR complex regulates polarity in many cell types, Crb function in polarity is relatively specific to epithelial cells. Together Cdc42-PAR6-aPKC-Bazooka and Crb orchestrate the differentiation of the photoreceptor apical membrane (AM and zonula adherens (ZA, thus allowing these cells to assemble into a neuro-epithelial lattice. In addition to its function in epithelial polarity, Crb has also been shown to protect fly photoreceptors from light-induced degeneration, a process linked to Rhodopsin expression and trafficking. Remarkably, mutations in the human Crumbs1 (CRB1 gene lead to retinal degeneration, making the fly photoreceptor a powerful disease model system.

  18. 102 La décoloration des rejets liquides de textile (noir de soufre) par ...

    African Journals Online (AJOL)

    pc

    Résumé. Dans cette étude, nous nous intéressons au traitement d'un rejet de coloration de textile par voie ... L'industrie textile utilise environs 10 000 types de colorants, la ..... Electrochemical coagulation for textile effluent decolorization.

  19. L'obtention du crédit bancaire par les PME au Cameroun

    African Journals Online (AJOL)

    Doctorante en sciences de gestion Université de Ngaoundéré, Cameroun. .... vient à point nommé dans son contexte et dans son domaine dans la mesure ... confrontant la performance des entreprises à leur structure financière, Wanda ..... est le plus souvent la perte du contrôle de l'entreprise par les actionnaires.

  20. Two-year survival of glass ionomer sealanTs placed as parT of ...

    African Journals Online (AJOL)

    2010-09-09

    Sep 9, 2010 ... Two-year survival of glass ionomer sealanTs placed as parT of proximal aTraumaTic. resToraTive ... absTracT. Objective: To evaluate after two years, the survival rate of glass ionomer cement (gic) ... or symptoms of periodontal disease, and clinically the ..... saliva contamination on the bond of dentine resin-.

  1. PAR as a way of organising a social workers labour union in Greenland

    DEFF Research Database (Denmark)

    Andersen, John; Arnfjord, Steven

    Abstract, ALARA2015012:PAR as a way of organising a social workers labour union in Greenland for consideration and inclusion in the programme for the ALARA 9th Action Learning Action Research and 13th Participatory Action Research World Congress to be held at St. George Hotel and Conference Centre...

  2. Determining fPAR and leaf area index of several land cover classes ...

    African Journals Online (AJOL)

    ... fraction of photosynthetically active radiation (fPAR), are three fundamental biophysical characteristics of the plant canopy that should parameterise ecophysiological models of water use (evapotranspiration) and carbon sequestration. Although Earth observation provides values and time series for both these parameters, ...

  3. Plant-derived SAC domain of PAR-4 (Prostate Apoptosis Response 4 exhibits growth inhibitory effects in prostate cancer cells

    Directory of Open Access Journals (Sweden)

    Shayan eSarkar

    2015-10-01

    Full Text Available The gene Par-4 (Prostate Apoptosis Response 4 was originally identified in prostate cancer cells undergoing apoptosis and its product Par-4 showed cancer specific pro-apoptotic activity. Particularly, the SAC domain of Par-4 (SAC-Par-4 selectively kills cancer cells leaving normal cells unaffected. The therapeutic significance of bioactive SAC-Par-4 is enormous in cancer biology; however, its large scale production is still a matter of concern. Here we report the production of SAC-Par-4-GFP fusion protein coupled to translational enhancer sequence (5′ AMV and apoplast signal peptide (aTP in transgenic Nicotiana tabacum cv. Samsun NN plants under the control of a unique recombinant promoter M24. Transgene integration was confirmed by genomic DNA PCR, Southern and Northern blotting, Real-time PCR and Nuclear run-on assays. Results of Western blot analysis and ELISA confirmed expression of recombinant SAC-Par-4-GFP protein and it was as high as 0.15% of total soluble protein. In addition, we found that targeting of plant recombinant SAC-Par-4-GFP to the apoplast and endoplasmic reticulum (ER was essential for the stability of plant recombinant protein in comparison to the bacterial derived SAC-Par-4. Deglycosylation analysis demonstrated that ER-targeted SAC-Par-4-GFP-SEKDEL undergoes O-linked glycosylation unlike apoplast-targeted SAC-Par-4-GFP. Furthermore, various in vitro studies like mammalian cells proliferation assay (MTT, apoptosis induction assays, and NF-κB suppression suggested the cytotoxic and apoptotic properties of plant-derived SAC-Par-4-GFP against multiple prostate cancer cell lines. Additionally, pre-treatment of MAT-LyLu prostate cancer cells with purified SAC-Par-4-GFP significantly delayed the onset of tumor in a syngeneic rat prostate cancer model. Taken altogether, we proclaim that plant made SAC-Par-4 may become a useful alternate therapy for effectively alleviating cancer in the new era.

  4. Project Plan 7930 Cell G PaR Remote Handling System Replacement

    International Nuclear Information System (INIS)

    Kinney, Kathryn A.

    2009-01-01

    For over 40 years the US Department of Energy (DOE) and its predecessors have made Californium-252 ( 252 Cf) available for a wide range of industries including medical, nuclear fuels, mining, military and national security. The Radiochemical Engineering Development Center (REDC) located within the Oak Ridge National Laboratory (ORNL) processes irradiated production targets from the High Flux Isotope Reactor (HFIR). Operations in Building 7930, Cell G provide over 70% of the world's demand for 252 Cf. Building 7930 was constructed and equipped in the mid-1960s. Current operations for 252 Cf processing in Building 7930, Cell G require use of through-the-wall manipulators and the PaR Remote Handling System. Maintenance and repairs for the manipulators is readily accomplished by removal of the manipulator and relocation to a repair shop where hands-on work can be performed in glove boxes. Contamination inside cell G does not currently allow manned entry and no provisions were created for a maintenance area inside the cell. There has been no maintenance of the PaR system or upgrades, leaving operations vulnerable should the system have a catastrophic failure. The Cell G PaR system is currently being operated in a run to failure mode. As the manipulator is now 40+ years old there is significant risk in this method of operation. In 2006 an assessment was completed that resulted in recommendations for replacing the manipulator operator control and power centers which are used to control and power the PaR manipulator in Cell G. In mid-2008 the chain for the bridge drive failed and subsequent examinations indicated several damaged links (see Figure 1). To continue operations the PaR manipulator arm is being used to push and pull the bridge as a workaround. A retrieval tool was fabricated, tested and staged inside Cell G that will allow positioning of the bridge and manipulator arm for removal from the cell should the PaR system completely fail. A fully functioning and

  5. Radiological findings and healing patterns of incomplete stress fractures of the pars interarticularis

    International Nuclear Information System (INIS)

    Dunn, Andrew J.; Campbell, Robert S.D.; Mayor, Peter E.; Rees, Dai

    2008-01-01

    The objective was to retrospectively record the CT and MRI features and healing patterns of acute, incomplete stress fractures of the pars interarticularis. The CT scans of 156 adolescents referred with suspected pars interarticularis stress fractures were reviewed. Patients with incomplete (grade 2) pars fractures were included in the study. Fractures were assessed on CT according to vertebral level, location of cortical involvement and direction of fracture propagation. MRI was also performed in 72 of the 156 cases. MRI images of incomplete fractures were assessed for the presence of marrow oedema and cortical integrity. Fracture healing patterns were characterised on follow-up CT imaging. Twenty-five incomplete fractures were identified in 23 patients on CT. All fractures involved the inferior or infero-medial cortex of the pars and propagated superiorly or superolaterally. Ninety-two percent of incomplete fractures demonstrated either complete or partial healing on follow-up imaging. Two (8%) cases progressed to complete fractures. Thirteen incomplete fractures in 11 patients confirmed on CT also had MRI, and 92% demonstrated oedema in the pars. Ten out of thirteen fractures (77%) showed a break in the infero-medial cortex with intact supero-lateral cortex, which correlated with the CT findings. MRI incorrectly graded one case as a complete (grade 3) fracture, and 2 cases as (grade 1) stress reaction. Six fractures had follow-up MRI, 67% showed partial or complete cortical healing, and the same number showed persistent marrow oedema. Incomplete fracture of the pars interarticularis represents a stage of the evolution of a complete stress fracture. The direction of fracture propagation is consistent, and complete healing can be achieved in most cases with appropriate clinical management. CT best demonstrates fracture size and extent, and is the most appropriate modality for follow-up. MRI is limited in its ability to fully depict the cortical integrity of

  6. Radiological findings and healing patterns of incomplete stress fractures of the pars interarticularis

    Energy Technology Data Exchange (ETDEWEB)

    Dunn, Andrew J.; Campbell, Robert S.D. [Royal Liverpool and Broadgreen University Teaching Hospitals, Department of Medical Imaging, Liverpool (United Kingdom); Mayor, Peter E. [Leighton Hospital, Department of Medical Imaging, Crewe, Cheshire (United Kingdom); Rees, Dai [Robert Jones and Agnes-Hunt Orthopaedic Hospital, Department of Orthopaedic Surgery, Oswestry, Shropshire (United Kingdom)

    2008-05-15

    The objective was to retrospectively record the CT and MRI features and healing patterns of acute, incomplete stress fractures of the pars interarticularis. The CT scans of 156 adolescents referred with suspected pars interarticularis stress fractures were reviewed. Patients with incomplete (grade 2) pars fractures were included in the study. Fractures were assessed on CT according to vertebral level, location of cortical involvement and direction of fracture propagation. MRI was also performed in 72 of the 156 cases. MRI images of incomplete fractures were assessed for the presence of marrow oedema and cortical integrity. Fracture healing patterns were characterised on follow-up CT imaging. Twenty-five incomplete fractures were identified in 23 patients on CT. All fractures involved the inferior or infero-medial cortex of the pars and propagated superiorly or superolaterally. Ninety-two percent of incomplete fractures demonstrated either complete or partial healing on follow-up imaging. Two (8%) cases progressed to complete fractures. Thirteen incomplete fractures in 11 patients confirmed on CT also had MRI, and 92% demonstrated oedema in the pars. Ten out of thirteen fractures (77%) showed a break in the infero-medial cortex with intact supero-lateral cortex, which correlated with the CT findings. MRI incorrectly graded one case as a complete (grade 3) fracture, and 2 cases as (grade 1) stress reaction. Six fractures had follow-up MRI, 67% showed partial or complete cortical healing, and the same number showed persistent marrow oedema. Incomplete fracture of the pars interarticularis represents a stage of the evolution of a complete stress fracture. The direction of fracture propagation is consistent, and complete healing can be achieved in most cases with appropriate clinical management. CT best demonstrates fracture size and extent, and is the most appropriate modality for follow-up. MRI is limited in its ability to fully depict the cortical integrity of

  7. Managing Public Accountability : How Public Managers Manage Public Accountability

    NARCIS (Netherlands)

    Schillemans, Thomas

    2015-01-01

    Accountability is of growing importance in contemporary governance. The academic literature on public accountability is fraught with concerned analyses, suggesting that accountability is a problematic issue for public managers. This article investigates how public managers experience accountability

  8. Public relations

    International Nuclear Information System (INIS)

    1997-01-01

    Nuclear Regulatory Authority of the Slovak Republic (NRA SR) started building up a broad information publicity conception resulting in NRA SR Information Centre establishment in 1995. The Centre provides information on the NRA SR activities. The Authority's speaker provides information about NRA SR domestic and foreign activities for TASR, newspapers, Slovak radio and television. Information on nuclear energy facilities situation is given to state authorities, organizations as well as to domestic and foreign mass-media on request. 41 press releases, 3 radio interviews and 5 television records providing information on some important NRA SR events was worked out in 1996. 4 basic NRA SR document have been presented by the Slovak Information Agency, consequently 3 press-conferences were held. Concerning some less frequent communication activities, NRA SR can present the NRA SR annual report in three versions (for the Slovak Government, for public and detailed report for experts). NRA SR and State Authority for Nuclear Safety of the Czech Republic issue together Nuclear Energy Safety News every two months. NRA SR activities Bulletin started issuing in 1996 3 to 4 volumes per year. Newspaper, radio and television news monitoring is performed for Bratislava and Trnava offices providing interesting papers or important events records and photos of NRA SR visits. Practical experience of the information activities performance in connection with the Authority mission and liability was obtained last year. Methodical and organizational guidelines to adjust the state regulatory authority activities in this field have been prepared

  9. Effectiveness of the EMPOWER-PAR Intervention in Improving Clinical Outcomes of Type 2 Diabetes Mellitus in Primary Care: A Pragmatic Cluster Randomised Controlled Trial.

    Science.gov (United States)

    Ramli, Anis Safura; Selvarajah, Sharmini; Daud, Maryam Hannah; Haniff, Jamaiyah; Abdul-Razak, Suraya; Tg-Abu-Bakar-Sidik, Tg Mohd Ikhwan; Bujang, Mohamad Adam; Chew, Boon How; Rahman, Thuhairah; Tong, Seng Fah; Shafie, Asrul Akmal; Lee, Verna K M; Ng, Kien Keat; Ariffin, Farnaza; Abdul-Hamid, Hasidah; Mazapuspavina, Md Yasin; Mat-Nasir, Nafiza; Chan, Chun W; Yong-Rafidah, Abdul Rahman; Ismail, Mastura; Lakshmanan, Sharmila; Low, Wilson H H

    2016-11-14

    The chronic care model was proven effective in improving clinical outcomes of diabetes in developed countries. However, evidence in developing countries is scarce. The objective of this study was to evaluate the effectiveness of EMPOWER-PAR intervention (based on the chronic care model) in improving clinical outcomes for type 2 diabetes mellitus using readily available resources in the Malaysian public primary care setting. This was a pragmatic, cluster-randomised, parallel, matched pair, controlled trial using participatory action research approach, conducted in 10 public primary care clinics in Malaysia. Five clinics were randomly selected to provide the EMPOWER-PAR intervention for 1 year and another five clinics continued with usual care. Patients who fulfilled the criteria were recruited over a 2-week period by each clinic. The obligatory intervention components were designed based on four elements of the chronic care model i.e. healthcare organisation, delivery system design, self-management support and decision support. The primary outcome was the change in the proportion of patients achieving HbA1c diabetes mellitus patients were recruited at baseline (intervention: 471 vs. 417). At 1-year, 96.6 and 97.8% of patients in the intervention and control groups completed the study, respectively. The baseline demographic and clinical characteristics of both groups were comparable. The change in the proportion of patients achieving HbA1c target was significantly higher in the intervention compared to the control group (intervention: 3.0% vs. -4.1%, P diabetes in the Malaysian public primary care setting. Registered with: ClinicalTrials.gov.: NCT01545401 . Date of registration: 1st March 2012.

  10. Spondylolysis outcomes in adolescents after direct screw repair of the pars interarticularis.

    Science.gov (United States)

    Snyder, Laura A; Shufflebarger, Harry; O'Brien, Michael F; Thind, Harjot; Theodore, Nicholas; Kakarla, Udaya K

    2014-09-01

    Isthmic spondylolysis can significantly decrease functional abilities, especially in adolescent athletes. Although treatment can range from observation to surgery, direct screw placement through the fractured pars, or Buck's procedure, may be a more minimally invasive procedure than the more common pedicle screw-hook construct. Review of surgical databases identified 16 consecutive patients treated with Buck's procedure from 2004 to 2010. Twelve patients were treated at Miami Children's Hospital and 4 at Barrow Neurological Institute. Demographics and clinical and radiographic outcomes were recorded and analyzed retrospectively. The 16 patients had a median age of 16 years, and 14 were 20 years or younger at the time of treatment. Symptoms included axial back pain in 100% of patients with concomitant radiculopathy in 38%. Pars defects were bilateral in 81% and unilateral in 19% for a total of 29 pars defects treated using Buck's procedure. Autograft or allograft augmented with recombinant human bone morphogenetic protein as well as postoperative bracing was used in all cases. Postoperatively, symptoms resolved completely or partially in 15 patients (94%). Of 29 pars defects, healing was observed in 26 (89.6%) prior to 1 revision surgery, and an overall fusion rate of 97% was observed at last radiological follow-up. There were no implant failures. All 8 athletes in this group had returned to play at last follow-up. Direct screw repair of the pars interarticularis defect as described in this series may provide a more minimally invasive treatment of adolescent patients with satisfactory clinical and radiological outcomes, including return to play of adolescent athletes.

  11. Incorporating GOES Satellite Photosynthetically Active Radiation (PAR) Retrievals to Improve Biogenic Emission Estimates in Texas

    Science.gov (United States)

    Zhang, Rui; White, Andrew T.; Pour Biazar, Arastoo; McNider, Richard T.; Cohan, Daniel S.

    2018-01-01

    This study examines the influence of insolation and cloud retrieval products from the Geostationary Operational Environmental Satellite (GOES) system on biogenic emission estimates and ozone simulations in Texas. Compared to surface pyranometer observations, satellite-retrieved insolation and photosynthetically active radiation (PAR) values tend to systematically correct the overestimation of downwelling shortwave radiation in the Weather Research and Forecasting (WRF) model. The correlation coefficient increases from 0.93 to 0.97, and the normalized mean error decreases from 36% to 21%. The isoprene and monoterpene emissions estimated by the Model of Emissions of Gases and Aerosols from Nature are on average 20% and 5% less, respectively, when PAR from the direct satellite retrieval is used rather than the control WRF run. The reduction in biogenic emission rates using satellite PAR reduced the predicted maximum daily 8 h ozone concentration by up to 5.3 ppbV over the Dallas-Fort Worth (DFW) region on some days. However, episode average ozone response is less sensitive, with a 0.6 ppbV decrease near DFW and 0.3 ppbV increase over East Texas. The systematic overestimation of isoprene concentrations in a WRF control case is partially corrected by using satellite PAR, which observes more clouds than are simulated by WRF. Further, assimilation of GOES-derived cloud fields in WRF improved CAMx model performance for ground-level ozone over Texas. Additionally, it was found that using satellite PAR improved the model's ability to replicate the spatial pattern of satellite-derived formaldehyde columns and aircraft-observed vertical profiles of isoprene.

  12. Elimination of slightly radioactive liquid effluent by dilution. Its consequences (1960); Elimination par dilution d'effluents liquides faiblement radioactifs. Leurs consequences (1960)

    Energy Technology Data Exchange (ETDEWEB)

    Bovard, P; Candillon, C [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1960-07-01

    Nuclear centres often have to solve problems raised by the elimination of large volumes of slightly radioactive liquid effluent. As things stand at present, the method usually adopted consists in expelling this effluent into the main water system in order to dilute it to a maximum, and thus to lower its radioactive isotope concentration to below the norms imposed by the Public Health Service. This technique requires systematic checking of the water system and its dependences, and demands a thorough knowledge of adsorption and fixation processes. (author) [French] Les centres nucleaires ont frequemment a resoudre des problemes poses par l'elimination de volumes importants d'effluents liquides faiblement radioactifs. Dans l'etat actuel des choses, la solution la plus utilisee consiste a rejeter ces effluents dans le reseau hydrographique de maniere a les diluer au maximum et abaisser ainsi leurs teneurs en isotopes radioactifs au-dessous des normes imposees par la Sante Publique. Cette technique necessite un controle systematique du reseau et de ses dependances et demande une connaissance approfondie des processus d'adsorption et de fixation. (auteur)

  13. Public Sector Wage Growth in Alberta

    Directory of Open Access Journals (Sweden)

    Ken Boessenkool

    2012-01-01

    Full Text Available In recent years, Alberta’s fiscal stance has shifted from large surpluses to deficits, and a large part of the blame appears to be due to rising public sector salaries. Since 2000, the province’s public sector wage bill has shot up by 119 percent — almost double the rate of growth in the rest of Canada. Wages, previously roughly at par with the rest of the country, are now higher (in many cases very substantially across all public sector categories, including health care, social services, education and government, consuming 95 percent of the increase in provincial revenues over the past decade. At the same time, the number of public sector employees has grown faster than the overall population; it is difficult to attribute this sharp uptick to a rise in productivity, or the need to compete with private industry for skilled workers. This paper breaks down the increases in every category, arguing that if the provincial government is looking to trim expenditures, public sector salaries are a good place to start. The authors make their case using detailed Statistics Canada data, throwing down the gauntlet to defenders of the status quo and challenging them to justify these disparate increases.

  14. Public meeting

    CERN Multimedia

    HR Department

    2010-01-01

    Dear Colleagues, I am pleased to invite you to a public meeting which will be held on Thursday 11 November 2010 at 2:30 p.m., in the Main Auditorium (welcome coffee from 2 p.m.) In this meeting Sigurd Lettow, Director for Administration and General Infrastructure will present the Management’s proposals towards restoring full funding of the Pension Fund. The meeting will follow discussions which took place with the Staff Association, at the Standing Concertation Committee (CCP) of 1 November 2010 and will be held with the Members States, at the Tripartite Employment Conditions Forum (TREF) of 4 November 2010. You will be able to attend this presentation in the Main Auditorium or via the webcast. The Management will also be available to reply to your questions on this subject. Best regards, Anne-Sylvie Catherin

  15. Public meetings

    CERN Multimedia

    Staff Association

    2013-01-01

    MARS SURVEY 5YR 2015 GENERAL INFORMATION ELECTIONS 2013   COME AND BE INFORMED! Public meetings Tuesday 1st Oct. 10 am Amphi IT, 31-3-004 Meyrin Tuesday 1st Oct. 2 pm Council Chamber, 503-1-001 Meyrin Friday 4 Oct. 10 am Amphi BE, 864-1-D02 Prévessin Monday 7 Oct. 2 pm Council Chamber, 503-1-001 (in English) Meyrin Tuesday 8 Oct. 10 am Amphi Kjell Johnsen, 30-7-018 Meyrin   Overview of the topics to be discussed Recognition of Merit – MARS Outcome of last exercise 2007 to 2013: lessons learned Survey: five-yearly review, give us your opinion General information CVI 2014 Voluntary programmes (PRP, SLS) Elections 2013 Renewal of the Staff Council 2014 - 2015  

  16. Public acceptance and public relations

    International Nuclear Information System (INIS)

    Tanaka, Yasumasa

    1977-01-01

    A set of problems are discussed, which must be studied before the public relations are dealt with. Firstly, the trade-off between energy and health must be considered. There were several ages in which the consideration on health took preference to the energy requirement in the past. For example, the use of coal in London was prohibited by the King's proclamation in 1,306. Secondly, the selection for the acceptance of atomic power development and utilization is based on the subjective susceptibility psychologically, and cannot be concluded only by the logical reasoning. Thirdly, the strict definition of ''national consensus'' is necessary. That is, whether does it mean pleviscite or mere mood. Fourthly, whether the atomic energy is free from the danger or death biologically or not. Fifthly, is there any method for discriminating the persons who accept atomic power from the persons who do not socially. Although the probability of death caused by atomic accidents is very small (one three hundred millionth a year), many peoples hate atomic power and oppose to the construction of nuclear power plants. Four reasons for this are considered: (1) social diffusion of innovation, (2) nuclear allergy, (3) shortage of the conception of risk-benefit, and (4) heterogeneity of the public. According to the investigation of the relationship between electric power and livelihood, carried out by the policy and science research institute in Tokyo, the highly subjective decision for the acceptance of atomic power is independent of the objective knowledge on atomic power. (Iwakiri, K.)

  17. A arte de curar dos profissionais de saúde popular em tempo de cólera: Grão-Pará do século XIX The curative art of specialists in folk medicine in times of cholera: 19th century Grão-Pará

    Directory of Open Access Journals (Sweden)

    Jane Felipe Beltrão

    2000-09-01

    Full Text Available Durante a epidemia de cólera que assolou o Grão-Pará, em 1855, pouco mais de uma dezena de anônimos profissionais de saúde popular inscreveram suas artes de curar nos anais da história. As terapias não eram muitas, mas foram disseminadas nos jornais provinciais ou pela forte tradição oral presente na Amazônia. Uma dessas terapias - o uso do sumo de limão - chegou a ser avalizada pelos médicos da província como cientificamente correta. Os homens que "não eram médicos, nem cirurgiões" usavam ervas e frutos medicinais preparados em sumos, infusões, banhos, emplastos e supositórios, rompendo as fronteiras estabelecidas pela arte oficial de curar, a medicina alopática, que tentava estabelecer-se hegemonicamente. Descrevo a trilha da cólera até o Grão-Pará e analiso o contexto social da epidemia; os conhecimentos sobre a cólera: as possibilidades de socorro oferecidas à população e as práticas curativas então adotadas.During the cholera epidemics that affected the Grão-Pará Province in 1855, not more than ten anonymous public health professionals registered in history their curing powers as they relieved cholera victims. There were not too many therapies, but they were publicized in letters printed in local newspapers. The therapeutical powers of alternative medicine was disseminated throughout the Amazon thanks to the strong oral history tradition. One of such therapies - the usage of lemon juice - was adopted by medical doctors in the Province and later on scientifically accredited. Citizens who "were not doctors, nor surgeons" used medicinal herbs and fruits to prepare juices, infusions, baths, plasters and suppositories. They went over the limits established by the official medicine, allopathy, which acted hegemonically. The article describes the path that cholera traveled to reach Grão-Pará and the ensuing scourge of Belém. Data are presented on mortality, the social context of the event, health-care knowledge

  18. Public History

    Directory of Open Access Journals (Sweden)

    Marta Gouveia de Oliveira Rovai

    2017-04-01

    Full Text Available Este artigo tem como proposta apresentar o conceito e as práticas de História Pública como um novo posicionamento da ciência histórica em diálogo com profissionais da comunicação, no sentido de produzir e divulgar as experiências humanas. Para isso, discute-se a origem do conceito de História Pública e as diferentes formas de educação histórica que a utilização das novas tecnologias podem proporcionar (dentre elas a internet. Nesse sentido, convida-se o leitor para a reflexão sobre as possibilidades de publicização e de democratização do conhecimento histórico e da cultura, ampliando-se a oportunidade de produção, de divulgação e de acesso do público a diferentes formas experiências no tempo. O artigo também intenciona chamar atenção dos profissionais que lidam com a História e com a Comunicação para os perigos de produções exclusivamente submetidas ao mercado que transformam a popularização da História no reforço de estigmas culturais.   PALAVRAS-CHAVE: História Pública; Educação histórica e Comunicação; democratização e estigmatização.     ABSTRACT This article aims to present the concept and practices of Public History as a new positioning of historical science in dialogue with communication professionals, in the sense of producing and disseminating human experiences. For this, the origin of the concept of Public History and the different forms of historical education that the use of the new technologies can provide (among them the Internet is discussed. In this sense, the reader is invited to reflect on the possibilities of publicizing and democratizing historical knowledge and culture, expanding the opportunity for production, dissemination and public access to different forms of experience in time. The article also intends to draw attention from professionals dealing with History and Communication to the dangers of exclusively commercialized productions that transform the popularization

  19. Direction des Publications

    African Journals Online (AJOL)

    Synthese

    Comportement à la corrosion de couches minces nano structurées. FexSiy, élaborées par ... Fe1-xSix thin films were obtained by DC magnetron sputtering on glass substrates. The alloys were prepared from pure Fe and Si targets. The alloys ...

  20. Direction des Publications

    African Journals Online (AJOL)

    Synthese

    économique des services rendus par les écosystèmes marins. La richesse ... croissance plus rapide que la moyenne de l‟économie ...... services and natural capital. Nature. 387, 253-260. .... d‟interactions où l‟humain est partie prenante. In.

  1. Orientação sexual nos parâmetros curriculares nacionais Sexual Orientation at the National Curriculum Parameters

    Directory of Open Access Journals (Sweden)

    HELENA ALTMANN

    2001-01-01

    Full Text Available A sexualidade é atualmente vista como um problema de saúde pública, sendo a escola local privilegiado de implementação de políticas públicas que promovam a saúde de crianças e adolescentes. Assim, ela foi constituída, de acordo com os Parâmetros Curriculares Nacionais (PCNs, em tema transversal, a fim de disseminar-se por todo campo pedagógico e irradiar seus efeitos em domínios os mais heterogêneos, dentre outros, na Educação Física. Esta pesquisa analisou o dispositivo da sexualidade nos PCNs, buscando identificar a concepção de sexualidade ali presente, a singularidade histórica desta proposta e seus possíveis efeitos na escola e, mais especificamente, na Educação Física.Today, sexuality is considered a matter of public health, and the school is a privileged place for the implementation of public policies that promote children's and adolescents' health. Thus, it has been established, in agreement with the National Curriculum Parameters (PCNs, as a transversal theme in order to disseminate itself throughout the whole pedagogical field and to broaden its effects in a wide range of different areas, including Physical Education. This research analyzes the requirements of sexuality in the PCNs with the aim of identifying the use of the sexuality concept, the historical uniqueness of this proposal and its possible effects at schools, more specifically through Physical Education.

  2. Epidemiology of pituitary pars intermedia dysfunction: A systematic literature review of clinical presentation, disease prevalence and risk factors.

    Science.gov (United States)

    Ireland, J L; McGowan, C M

    2018-05-01

    Pituitary pars intermedia dysfunction (PPID) is caused by an age-related degenerative disease of dopaminergic neurones. Despite its importance in equine practice, available information regarding its epidemiology is limited. This systematic review aimed to assess published literature to evaluate available evidence regarding the clinical presentation, prevalence and risk factors for PPID in horses and ponies. Electronic database searches were undertaken using a range of terms, and English language publications published prior to August 2016 were included. Both authors independently reviewed screened papers for inclusion, extracted data, and assessed the quality of reporting using predefined criteria. Data were extracted using modified critically appraised topic data collection forms. Meta-analysis was not undertaken due to marked between-study variations. Following removal of duplicate records, of 358 published papers yielded by the search, 97 abstracts were screened for eligibility and 29 publications meeting inclusion criteria were included in the review. Most studies reviewed were case series or cross-sectional studies, with considerable variation in study populations and PPID case definition. Hypertrichosis and/or other hair coat abnormalities, laminitis and epaxial muscle wastage or muscle atrophy are the most frequently reported clinical signs, with prevalence of these signs increasing with increasing horse age. The most robust prevalence estimates for PPID were 21.2% in horses and ponies aged ≥15 years and 2.9% amongst the general equine population. Findings regarding breed and sex predispositions were equivocal and only increasing age has been identified as a significant risk factor for PPID. Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

  3. Public Relations Strategies for Scholastic Publication Staffs.

    Science.gov (United States)

    Konkle, Bruce E.

    2000-01-01

    Discusses the importance to scholastic publications staffs of four public relations strategies: meticulous research, systematic planning, strengthening communication efforts, and evaluation. Notes internal and external factors crucial to good public relations. Lists activities to consider. (SR)

  4. Screening of phytochemicals against protease activated receptor 1 (PAR1), a promising target for cancer.

    Science.gov (United States)

    Kakarala, Kavita Kumari; Jamil, Kaiser

    2015-02-01

    Drug resistance and drug-associated toxicity are the primary causes for withdrawal of many drugs, although patient recovery is satisfactory in many instances. Interestingly, the use of phytochemicals in the treatment of cancer as an alternative to synthetic drugs comes with a host of advantages; minimum side effects, good human absorption and low toxicity to normal cells. Protease activated receptor 1 (PAR1) has been established as a promising target in many diseases including various cancers. Strong evidences suggest its role in metastasis also. There are no natural compounds known to inhibit its activity, so we aimed to identify phytochemicals with antagonist activity against PAR1. We screened phytochemicals from Naturally Occurring Plant-based Anticancer Compound-Activity-Target database (NPACT, http://crdd.osdd.net/raghava/npact/ ) against PAR1 using virtual screening workflow of Schrödinger software. It analyzes pharmaceutically relevant properties using Qikprop and calculates binding energy using Glide at three accuracy levels (high-throughput virtual screening, standard precision and extra precision). Our study led to the identification of phytochemicals, which showed interaction with at least one experimentally determined active site residue of PAR1, showed no violations to Lipinski's rule of five along with predicted high human absorption. Furthermore, structural interaction fingerprint analysis indicated that the residues H255, D256, E260, S344, V257, L258, L262, Y337 and S344 may play an important role in the hydrogen bond interactions of the phytochemicals screened. Of these residues, H255 and L258 residues were experimentally proved to be important for antagonist binding. The residues Y183, L237, L258, L262, F271, L332, L333, Y337, L340, A349, Y350, A352, and Y353 showed maximum hydrophobic interactions with the phytochemicals screened. The results of this work suggest that phytochemicals Reissantins D, 24,25-dihydro-27-desoxywithaferin A, Isoguaiacin

  5. [Roles of protease-activated receptor-2 (PAR-2), a G protein-coupled receptor, in modulation of exocrine gland functions].

    Science.gov (United States)

    Nishikawa, Hiroyuki

    2006-07-01

    Protease-activated receptor-2 (PAR-2), a G protein-coupled receptor, is activated by proteolytic unmasking of the N-terminal extracellular tethered ligand that presumably binds to the extracellular loop 2 of the receptor itself. PAR-2 is widely distributed in the mammalian body and plays various roles in biological events in the cardiovascular, respiratory, alimentary, and central neurons systems. PAR-2-activating peptides administered systemically to mice and rats trigger prompt salivation in vivo. In an in vitro study, PAR-2 agonists including the endogenous PAR-2 activator trypsin induce secretion of amylase and mucin from isolated rat parotid glands and sublingual glands, respectively. PAR-2-activating peptides administered systemically also modulate pancreatic exocrine secretion in vivo as well as in vitro. In the gastric mucosa, PAR-2 stimulation enhances secretion of mucus and pepsinogen and suppresses acid secretion. Tear secretion can also be caused by PAR-2-related peptides in PAR-2-dependent and -independent manners. PAR-2 thus plays a general or key role in the regulation of exocrine secretion. This review focuses on the physiologic and/or pathophysiologic roles of PAR-2 in glandular exocrine secretion. The possibility of PAR-2 as a target for drug development is also discussed.

  6. The role of gyrA and parC mutations in fluoroquinolones-resistant Pseudomonas aeruginosa isolates from Iran

    Directory of Open Access Journals (Sweden)

    Roghayeh Nouri

    Full Text Available Abstract The aim of this study was to examine mutations in the quinolone-resistance-determining region (QRDR of gyrA and parC genes in Pseudomonas aeruginosa isolates. A total of 100 clinical P. aeruginosa isolates were collected from different university-affiliated hospitals in Tabriz, Iran. Minimum inhibitory concentrations (MICs of ciprofloxacin and levofloxacin were evaluated by agar dilution assay. DNA sequences of the QRDR of gyrA and parC were determined by the dideoxy chain termination method. Of the total 100 isolates, 64 were resistant to ciprofloxacin. No amino acid alterations were detected in gyrA or parC genes of the ciprofloxacin susceptible or ciprofloxacin intermediate isolates. Thr-83 → Ile substitution in gyrA was found in all 64 ciprofloxacin resistant isolates. Forty-four (68.75% of them had additional substitution in parC. A correlation was found between the number of the amino acid alterations in the QRDR of gyrA and parC and the level of ciprofloxacin and levofloxacin resistance of the P. aeruginosa isolates. Ala-88 → Pro alteration in parC was generally found in high level ciprofloxacin resistant isolates, which were suggested to be responsible for fluoroquinolone resistance. These findings showed that in P. aeruginosa, gyrA was the primary target for fluoroquinolone and additional mutation in parC led to highly resistant isolates.

  7. Public Entrepreneurship

    DEFF Research Database (Denmark)

    Hjorth, Daniel

    2013-01-01

    In this paper we want to affirm the desiring-social-change that we find in practices presently represented by theorists and policy-makers as examples of ‘social entrepreneurship’ (SE). We do this as an attempt to intensify the presence of the social and sociality in today's discourse on the entre......In this paper we want to affirm the desiring-social-change that we find in practices presently represented by theorists and policy-makers as examples of ‘social entrepreneurship’ (SE). We do this as an attempt to intensify the presence of the social and sociality in today's discourse...... on the entrepreneurship–society relationship. SE, as all entrepreneurship practices, operates by social and economic forces (limiting ourselves to those here), and generates social and economic outcomes (amongst others). Its second half, however, dominates the concept of SE, and our analysis seek to remedy this imbalance...... by focusing on the social productivity of entrepreneurship, on entrepreneurship desiring social change. We suggest ‘public entrepreneurship’ might grasp this as a more balanced concept that will also support a more precise analysis of the entrepreneurship–society relationship....

  8. Public meeting

    CERN Multimedia

    Staff Association

    2015-01-01

    Last Monday at 9 a.m. the Council Chamber was full, with several people standing, for the public meeting of the Staff Association. Simultaneously, many of our colleagues followed the presentations in the Amphitheatre in Prévessin. We would like to thank all of you for the interest you have shown and for your feedback. In the introduction we explained how the Staff Association represents the staff in its discussions with Management and Member States, and how the staff itself defined, by its participation in the 2013 staff survey, the priority assigned to various points related to the employment conditions. The position of the Staff Association regarding the new contract policy, to be implemented as of 31 March 2015 after approval by Council, was stated. Then, in the framework of the 2015 five-yearly review, the general approach that we would like to see for the new career structure, was explained. Concerning diversity, based on what we know about the situation in other international organiza...

  9. uPAR Expression Pattern in Patients with Urothelial Carcinoma of the Bladder--Possible Clinical Implications.

    Directory of Open Access Journals (Sweden)

    Line Hammer Dohn

    Full Text Available The objective of the present study was to confirm the expression and localisation pattern of the urokinase-type plasminogen activator receptor (uPAR focusing on its possible clinical relevance in patients with urothelial neoplasia of the bladder. uPAR is a central molecule in tissue remodelling during cancer invasion and metastasis and is an established prognostic marker in various cancer diseases other than bladder cancer. Formalin-fixed and paraffin-embedded tumour-tissue blocks from 186 patients treated with radical cystectomy were analysed. uPAR expression was scored as either negative or positive as well as by the actual score. Separate scores were obtained for cancer cells, macrophages and myofibroblasts at the invasive front and in tumour core. We were able to confirm, in an independent patient cohort, the tissue expression and localisation pattern of uPAR as investigated by Immunohistochemistry as well as a significant association between uPAR positivity and increasing tumour stage and tumour grade. This demonstrates the robustness of our previous and current findings. In addition the association between uPAR positive myofibroblasts and poor survival was reproduced. The highest hazard ratios for survival were seen for uPAR positive myofibroblasts both at the invasive front and in tumour core. Evaluating uPAR expression by the actual score showed a significant association between uPAR positive myofibroblasts in tumour core and an increased risk of cancer specific mortality. Our investigations have generated new and valuable biological information about the cell types being involved in tumour invasion and progression through the plasminogen activation system.

  10. Linear study and bundle adjustment data fusion; Application to vision localization; Recherche lineaire et fusion de donnees par ajustement de faisceaux; Application a la localisation par vision

    Energy Technology Data Exchange (ETDEWEB)

    Michot, J.

    2010-12-09

    integrate this additional information directly into an extended bundle adjustment, by adding a constraint term in the weighted cost function. We evaluate three methods (based on machine learning or regularization) that dynamically select the weight associated to the constraint and show that these methods can be used in a real time multi-sensor SLAM, and validate them with different types of constraint on the orientation or on the scale. Experiments conducted on real video sequences show that this technique of constrained bundle adjustment reduces the drifts observed with the classical vision algorithms and improves the global accuracy of the positioning system. (author) [French] Les travaux presentes dans ce manuscrit concernent le domaine de la localisation et la reconstruction 3D par vision artificielle. Dans ce contexte, la trajectoire d'une camera et la structure 3D de la scene filmee sont initialement estimees par des algorithmes lineaires puis optimisees par un algorithme non-lineaire, l'ajustement de faisceaux. Cette these presente tout d'abord une technique de recherche de l'amplitude de deplacement (recherche lineaire), ou line search pour les algorithmes de minimisation iterative. La technique proposee est non iterative et peut etre rapidement implantee dans un ajustement de faisceaux traditionnel. Cette technique appelee recherche lineaire algebrique globale (G-ALS), ainsi que sa variante a deux dimensions (Two way-ALS), accelerent la convergence de l'algorithme d'ajustement de faisceaux. L'approximation de l'erreur de reprojection par une distance algebrique rend possible le calcul analytique d'une amplitude de deplacement efficace (ou de deux pour la variante Two way-ALS), par la resolution d'un polynome de degre 3 (G-ALS) ou 5 (Two way-ALS). Nos experimentations sur des donnees simulees et reelles montrent que cette amplitude, optimale en distance algebrique, est performante en distance euclidienne, et permet

  11. Agrobiodiversity and ethnoknowledge in Gleba Nova Olinda I, Pará: social interactions and sharing of manioc's germplasm (Manihot Esculenta Crantz, Euphorbiaceae

    Directory of Open Access Journals (Sweden)

    Pedro Glécio Costa Lima

    2013-08-01

    Full Text Available A major concern of ethnobiology is to understand the social relations that favor the occurrence and expansion of biological diversity in the Neotropic. This article evaluates the richness of ethnovarieties of cassava cultivated in communities located in public forest lands named Gleba Nova Olinda I, Pará State, Brazil. Data were obtained in workshops with 46 informants, and were analyzed by qualitative and quantitative methods. There are at least 52 manioc ethnovarieties on this site and germplasm sharing occurs both inside and outside the community. The knowledge improvement on this agrobiological resource by community members shows the important role that the inhabitants play in biological conservation of Gleba Nova Olinda I. Thus, support to local development should be grounded on ethnoknowledge.

  12. Analysis of gyrA and parC mutations in enterococci from environmental samples with reduced susceptibility to ciprofloxacin

    DEFF Research Database (Denmark)

    Petersen, A.; Jensen, Lars Bogø

    2004-01-01

    The quinolone resistance determining regions of gyrA and parC in four species of enterococci from environmental samples with reduced susceptibility to ciprofloxacin were sequenced. The nucleotide sequence variations of parC could be related to the different enterococcal species. Mutations...... in Enterococcus faecalis and Enterococcus faecium related to reduced susceptibility were identical to mutations detected in E jaecalis and E. faecium of clinical origin. A minimal inhibitory concentration of 8 mug ml(-1) to ciprofloxacin was not associated with any mutations in the gyrA and parC gene...... of Enterococcus casseliflavus and Enterococcus gallinarum. These two species may be intrinsically less susceptible to ciprofloxacin....

  13. Metastatic breast cancer to the liver with hepatoid features and Hep Par 1 antibody positive mimicking hepatocellular carcinoma.

    Science.gov (United States)

    Affleck, Authur; Lyman, William B; Jacobs, W Carl; Livasy, Chad A; Martinie, John B; Iannitti, David A; Vrochides, Dionisios

    2018-05-09

    The hepatocyte paraffin 1 antibody (Hep Par 1) has a high positive predictive value for differentiating hepatocellular carcinoma from cholangiocarcinoma and metastatic carcinoma. 1 We report a case of metastatic breast cancer to the liver with hepatoid histology and strong positive staining for Hep Par 1 mimicking hepatocellular carcinoma. To our knowledge, primary breast carcinoma staining Hep Par 1 positive has not been reported in the setting of hepatic metastasis. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  14. Study of the critical scattering of neutrons by iron; Etude de la diffusion critique des neutrons par le fer

    Energy Technology Data Exchange (ETDEWEB)

    Galula, M; Jacrot, B; Mangin, J P [Commissariat a l' Energie Atomique, Saclay (France)

    1959-07-01

    The critical scattering of very slow neutrons by iron near critical point is measured by time of flight techniques. The VAN HOVE formula is verified and the geometrical parameters K{sub 1} et r{sub 1} introduced in this theory are determined. (author) [French] On etudie la diffusion critique des neutrons tres lents par le fer dans la region du point de Curie par une methode de temps de vol. On verifie la formule de VAN HOVE et on determine les parametres geometriques K{sub 1} et r{sub 1} introduit par ce dernier. (auteur)

  15. Algoritmo PSO para identificación de parámetros en un motor DC

    Directory of Open Access Journals (Sweden)

    César Duarte

    2010-01-01

    Full Text Available En este artículo se presenta la aplicación del algoritmo Particle Swarm Optimization (PSO como estrategia de búsqueda para determinar los parámetros de un sistema tipo caja gris. Este proceso de identificación se ilustra utilizando la respuesta a un escalón de un motor DC en lazo abierto. Para agilizar la identificación del sistema a través del uso de PSO, se limita el espacio de búsqueda usando la información que puede extraerse de la respuesta en el dominio del tiempo del sistema a identificar. Los resultados del proceso de identificación de los parámetros del motor se obtienen utilizando la herramienta PSOt disponible para entorno Matlab® desarrollada por Brian Birge.

  16. Estuarine morphometry governs optically active substances, Kd(PAR) and beam attenuation

    DEFF Research Database (Denmark)

    Lund-Hansen, L. C.; Nielsen, J. M.; Blüthgen, J.

    2013-01-01

    estuaries using OACs as input parameters. It is concluded that there are no large differences in OAC concentrations between the two estuaries. The spatial distributions of OACs and optical properties were significantly different and governed by the estuary morphometry, i.e. a power distribution......°N) at high discharges. The major difference was the spatial distribution of the optical properties against distance, best described by significant power functions in the ria, compared to significant linear functions in the coastal plain. It was hypothesized that estuarine morphometry could explain...... this spatial distribution. Partition and multiple regression analyses showed that Chl-a governed Kd(PAR) and beam attenuation coefficient in both estuaries. Significant, high correlations were obtained by multiple regression analyses in the estimation of Kd(PAR) and beam attenuation coefficients in the two...

  17. The conditioning of radioactive waste by bitumen; Conditionnement des dechets radioactifs par le bitume

    Energy Technology Data Exchange (ETDEWEB)

    Rodier, J; Scheidhauer, J; Malabre, M [Commissariat a l' Energie Atomique, Chusclan (France). Centre de Production de Plutonium de Marcoule

    1961-07-01

    The separation of radioactive sludge and waste by bitumen is studied. Results are given concerning various trials carried out on the lixiviation of the final product by water as a function of the pH, of the time, and of the composition. The conditions for carrying out this process of coating the waste are controlled from a radioactive point of view. (author) [French] L'isolement de boues radioactives et de dechets par le bitume est etudie. Les resultats de divers essais portant sur la lixiviation par l'eau du produit fini en fonction du pH, du temps et de la composition sont exposes. Les conditions de realisation de l'enrobage sont controlees au point de vue du risque radioactif. (auteur)

  18. Dosimetry of 64Cu-DOTA-AE105, a PET tracer for uPAR imaging

    DEFF Research Database (Denmark)

    Persson, Morten; El Ali, Henrik H.; Binderup, Tina

    2014-01-01

    64Cu-DOTA-AE105 is a novel positron emission tomography (PET) tracer specific to the human urokinase-type plasminogen activator receptor (uPAR). In preparation of using this tracer in humans, as a new promising method to distinguish between indolent and aggressive cancers, we have performed PET...... studies in mice to evaluate the in vivo biodistribution and estimate human dosimetry of 64Cu-DOTA-AE105. MethodsFive mice received iv tail injection of 64Cu-DOTA-AE105 and were PET/CT scanned 1, 4.5 and 22h post injection. Volume-of-interest (VOI) were manually drawn on the following organs: heart, lung......Favorable dosimetry estimates together with previously reported uPAR PET data fully support human testing of 64Cu-DOTA-AE105....

  19. Comprendre la ville par la chrono-chorématique: un essai prometteur

    Directory of Open Access Journals (Sweden)

    Roger Brunet

    2010-12-01

    Full Text Available Cet ensemble de chrono-chorématique urbaine est exemplaire par ses méthodes et par ses résultats. Travail pluridisciplinaire de recherche de grande qualité éthique et esthétique, il livre une approche efficace à la compréhension du développement et des structures urbaines. Il ouvre de larges perspectives comparatives et des voies d’amélioration des modèles généraux de l’élaboration et des transformations des espaces urbains, en relation avec les modèles généraux de la production de l’espace géographique. On souhaite que se multiplient les études de cas, et qu’elles s’étendent à d’autres milieux urbains, à d’autres cultures.

  20. Youth empowerment in context: exploring tensions in school-based yPAR.

    Science.gov (United States)

    Kohfeldt, Danielle; Chhun, Lina; Grace, Sarah; Langhout, Regina Day

    2011-03-01

    In much of the youth empowerment literature, researchers focus on the relationship between youth and adults involved in empowerment programs while neglecting the broader social framework in which these relationships and the program itself functions. Utilizing an ecological model, the current research examines the tensions that surfaced in attempts to create an empowering setting in an after-school PAR program with fifth-graders. Challenging assumptions about youth, structural challenges, and conflicting theories of change are highlighted. Results examine the role of sociocultural context as PAR researchers attempt to create a setting in which students gain skills to become change agents within their school. The study suggests that youth empowerment is a context dependent process that requires attention to a multiplicity of factors that influence possibilities for empowerment via second order change.