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  1. Elevated dioxin levels in chloracne cases twenty years after the Seveso, Italy accident

    Energy Technology Data Exchange (ETDEWEB)

    Baccarelli, A.; Pesatori, A.C.; Consonni, D.; Bonzini, M.; Giacomini, S.M.; Bertazzi, P.A. [EPOCA Research Center, Univ. of Milan (Italy); Mocarelli, P. [Dept. of Lab. Medicine, Univ. of Milan-Bicocca, Desio (Italy); Patterson, D.G. Jr. [Centers for Disease Control and Prevention, Atlanta, GA (United States); Caporaso, N.E.; Landi, M.T. [Div. of Cancer Epidemiology and Genetics, National Cancer Inst., NIH, DHHS, Bethesda, MD (United States)

    2004-09-15

    In July 1976, an industrial accident contaminated a residential area surrounding Seveso, Italy, with high levels of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD). The exposure was acute, relatively pure, and affected more than 45,000 men, women, and children. By February 1978, 193 chloracne cases, mostly children, had been identified in the exposed population. Twenty years after, we conducted a case-control study on subjects diagnosed with chloracne and control subjects, who had not developed chloracne after the accident, to evaluate their TCDD plasma levels, as well as the exposure-response relationship and possible determinants of susceptibility to TCDD effects in this population.

  2. Chloracne: From clinic to research

    Directory of Open Access Journals (Sweden)

    Qiang Ju

    2012-03-01

    Full Text Available Chloracne is the most sensitive and specific marker for a possible dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin intoxication. It is clinically characterized by multiple acneiform comedone-like cystic eruptions mainly involving face in the malar, temporal, mandibular, auricular/retroauricular regions, and the genitalia, often occurring in age groups not typical for acne vulgaris. Histopathology is essential for a definite diagnosis, which exhibits atrophy or absence of sebaceous glands as well as infundibular dilatation or cystic formation of hair follicles, hyperplasia of epidermis, and hyperpigmentation of stratum corneum. The appearance of chloracne and its clinical severity does not correlate with the blood levels of dioxins. Pathogenesis of chloracne remains largely unclear. An “aryl hydrocarbon receptor”-mediated signaling pathway affecting the multipotent stem cells in the pilosebaceous units is probably the major molecular mechanism inducing chloracne. Chloracne is resistant to all the available treatment modalities used to treat acne. The aim of treatment is to lower or to eliminate the accumulated dioxins in the body at the very beginning of intoxication, e.g., by using dioxin-chelating substances such as synthetic dietary fat substitutes. The problem of dioxin contamination and its potential health hazards should be taken seriously in the wave of industrial globalization in the twenty-first century. Clinicians, especially dermatologists, are in the forefront of early diagnosis of dioxin intoxication.

  3. Chloracne. Clinical manifestations and etiology

    Energy Technology Data Exchange (ETDEWEB)

    Zugerman, C. (Northwestern Univ., Chicago, IL (USA))

    1990-01-01

    Chloracne is a rare but important acneiform eruption often associated with the ingestion of chlorinated phenolic agents such as dioxins with subsequent toxicity from these chemicals. Clinically, chloracne can be distinguished from acne vulgaris by the distribution and appearance of the lesions and by taking a detailed history. In some instances, it may be associated with particularly xerotic skin, pigmentation, follicular hyperkeratosis, conjunctivitis, and actinic elastosis. Histologically, the primary lesion is a follicular plug containing keratinous material. Chloracne is difficult if not impossible to treat adequately and once present, may persist for years. Consequently, good hygiene, safe manufacturing processes so that no inhalation or skin contact is possible, and the elimination of atmospheric contamination are all necessary in the prevention of this potentially debilitating disease.34 references.

  4. Atypical odontalgia. A report of twenty-two cases.

    Science.gov (United States)

    Brooke, R I

    1980-03-01

    The findings in twenty-two cases of a condition that causes pain in the teeth and gingivae are presented. Two cases are described in detail. The importance of recognizing the problem and avoiding unnecessary dental treatment is stressed. The most effective treatment appears to be reassurance and the use of antidepressant drugs.

  5. 38 CFR 3.813 - Interim benefits for disability or death due to chloracne or porphyria cutanea tarda.

    Science.gov (United States)

    2010-07-01

    ... disability or death due to chloracne or porphyria cutanea tarda. 3.813 Section 3.813 Pensions, Bonuses, and... porphyria cutanea tarda. (a) Disability benefits. Except as provided in paragraph (c) of this section, a... Vietnam era, and who suffers from chloracne or porphyria cutanea tarda which became manifest within one...

  6. The Danish eID Case: Twenty years of Delay

    DEFF Research Database (Denmark)

    Hoff, Jens Villiam; Hoff, Frederik Villiam

    2010-01-01

    The focus of this article is to explain why there is still no qualified digital signature in Denmark as defined by the EU eSignatures Directive nor any other nationwide eID even though Denmark had an early start in eGovernment, and a high level of "e-readiness" compared to other nations. Laying out...... of intergovernmental coordination and lack of cooperation between public and private sector. However, with the recent tender on digital signatures won by the PBS and the roll-out of the NemID it seems that Denmark will finally - after twenty years of delay - have an eID which can be widely used in the public as well...

  7. Post-anesthetic cortical blindness in cats: twenty cases.

    Science.gov (United States)

    Stiles, J; Weil, A B; Packer, R A; Lantz, G C

    2012-08-01

    The medical records of 20 cats with post-anesthetic cortical blindness were reviewed. Information collected included signalment and health status, reason for anesthesia, anesthetic protocols and adverse events, post-anesthetic visual and neurological abnormalities, clinical outcome, and risk factors. The vascular anatomy of the cat brain was reviewed by cadaver dissections. Thirteen cats were anaesthetised for dentistry, four for endoscopy, two for neutering procedures and one for urethral obstruction. A mouth gag was used in 16/20 cats. Three cats had had cardiac arrest, whereas in the remaining 17 cases, no specific cause of blindness was identified. Seventeen cats (85%) had neurological deficits in addition to blindness. Fourteen of 20 cats (70%) had documented recovery of vision, whereas four (20%) remained blind. Two cats (10%) were lost to follow up while still blind. Ten of 17 cats (59%) with neurological deficits had full recovery from neurological disease, two (12%) had mild persistent deficits and one (6%) was euthanased as it failed to recover. Four cats (23%) without documented resolution of neurological signs were lost to follow up. Mouth gags were identified as a potential risk factor for cerebral ischemia and blindness in cats. Copyright © 2012 Elsevier Ltd. All rights reserved.

  8. An investigation of twenty-one cases of low-frequency noise complaints

    DEFF Research Database (Denmark)

    Pedersen, Christian Sejer; Møller, Henrik; Persson-Waye, Kerstin

    2007-01-01

    Twenty-one cases of low-frequency noise complaints were thoroughly investigated with the aim of answering the question whether it is real physical sound or low-frequency tinnitus that causes the annoyance. Noise recordings were made in the homes of the complainants taking the spatial variation of...

  9. Leadership for Twenty-First-Century Schools and Student Achievement: Lessons Learned from Three Exemplary Cases

    Science.gov (United States)

    Schrum, Lynne; Levin, Barbara B.

    2013-01-01

    The purpose of this research was to understand ways exemplary award winning secondary school leaders have transformed their schools for twenty-first-century education and student achievement. This article presents three diverse case studies and identifies ways that each school's leader and leadership team reconfigured its culture and expectations,…

  10. Werner's syndrome: twenty-four cases with a review of the Japanese medical literature.

    Science.gov (United States)

    Murata, K; Nakashima, H

    1982-05-01

    Twenty-four cases of Werner's syndrome were studied to define the clinical manifestations in comparison with those found in a clinical review of 153 cases in the Japanese medical literature. The conspicuous characteristics of the 24 patients were short stature, stocky trunk with thin limbs, low body weight, bird-like or "masked" face, early graying or loss of hair, high-pitched or hoarse voice, bilateral cataracts, and various scleroderma-like signs. Three signs not stressed previously were hyperreflexia, flat feet, and irregular dental development. The onsets and incidences of these manifestations during the seven-year serial study are described.

  11. Oral squamous cell carcinoma in patients twenty years of age or younger - Review and analysis of 186 reported cases

    NARCIS (Netherlands)

    Bodner, L.; Manor, E.; Friger, M.D.; van der Waal, I.

    2014-01-01

    To review the literature on reported cases of squamous cell carcinoma (SCC) of the oral cavity in patients twenty-years-of-age or younger. All well-documented cases of oral SCC in patients twenty-years-of-age or less, published between 1936 and 2012, were collected and the clinicopathologic features

  12. Twenty-first century learning after school: the case of 4-H.

    Science.gov (United States)

    Kress, Cathann

    2006-01-01

    Founded in the early 1900s, the 4-H Youth Development program can serve as a model for out-of-school programs of the twenty-first century. The 4-H pledge, repeated by its members--over 7 million, ranging in age from five to twenty--articulates its core values: "I pledge: My head to clearer thinking, My heart to greater loyalty, My hands to larger service, and My health to better living for my club, my community, my country, and my world." The 4-H Development movement was created to provide opportunities for rural children, to help them become constructive adults. Through an emphasis on "learning by doing," 4-H teaches children the habits of lifelong learning. Historically, 4-H has tapped into university-level advancements, extending such knowledge to youth and thereby giving them early access to scientific discoveries and technological progress. Members apply this learning in their communities through hands-on projects crossing a wide-range of pertinent topics. Research shows that 4-H members are more successful in school than other children and develop a wide range of skills essential in the twenty-first century. Thus, the author makes the case that the foundation of 4-H is exceptionally relevant in today's complex world, perhaps even more so than a century ago. 4-H is a leader in youth development, making it a natural model for twenty-first century after-school programs. Expanding on the 4-H pledge, the author outlines the principles a successful youth development program would have: an emphasis on leadership skills, a feeling of connection and belonging, a forum for exploring career opportunities, and a component of meaningful community service.

  13. Indication to Open Anatrophic Nephrolithotomy in the Twenty-First Century: A Case Report

    Directory of Open Access Journals (Sweden)

    Alfredo Maria Bove

    2012-01-01

    Full Text Available Introduction. Advances in endourology have greatly reduced indications to open surgery in the treatment of staghorn kidney stones. Nevertheless in our experience, open surgery still represents the treatment of choice in rare cases. Case Report. A 71-year-old morbidly obese female patient complaining about occasional left flank pain, and recurrent cystitis for many years, presented bilateral staghorn kidney stones. Comorbidities were obesity (BMI 36.2, hypertension, type II diabetes, and chronic obstructive pulmunary disease (COPD hyperlipidemia. Due to these comorbidities, endoscopic and laparoscopic approaches were not indicated. We offered the patient staged open anatrophic nephrolithotomy. Results. Operative time was 180 minutes. Blood loss was 500 cc. requiring one unit of packed red blood cells. Hospital stay was 7 days. The renal function was unaffected based on preoperative and postoperative serum creatinine levels. Stone-free status of the left kidney was confirmed after surgery with CT scan. Conclusions. Open surgery can represent a valid alterative in the treatment of staghorn kidney stones of very selected cases. A discussion of the current indications in the twenty-first century is presented.

  14. Chloracne, goiter, arthritis, and anemia after polychlorinated biphenyl poisoning: 14-year follow-Up of the Taiwan Yucheng cohort.

    Science.gov (United States)

    Guo, Y L; Yu, M L; Hsu, C C; Rogan, W J

    1999-09-01

    In 1979, a mass poisoning involving 2,000 people occurred in central Taiwan from ingestion of cooking oil contaminated by polychlorinated biphenyls (PCBs) and polychlorinated dibenzofurans (PCDFs). We studied the prevalence of medical conditions in the exposed individuals and in a neighborhood control group. Starting with a registry of the exposed individuals from 1983, we updated the addresses of exposed individuals and identified a control group matched for age, sex, and neighborhood in 1979. In 1993, individuals 30 years of age or older were interviewed by telephone. We obtained usable information from 795 exposed subjects and 693 control subjects. Lifetime prevalence of chloracne, abnormal nails, hyperkeratosis, skin allergy, goiter, headache, gum pigmentation, and broken teeth were observed more frequently in the PCB/PCDF-exposed men and women. The exposed women reported anemia 2. 3 times more frequently than controls. The exposed men reported arthritis and herniated intervertebral disks 4.1 and 2.9 times, respectively, more frequently than controls. There was no difference in reported prevalences of other medical conditions. We conclude that Taiwanese people exposed to high levels of PCBs and PCDFs reported more frequent medical problems, including skin diseases, goiter, anemia, and joint and spine diseases.

  15. [Tuberculous sacro-iliitis: a series of twenty-two cases].

    Science.gov (United States)

    Bouajina, E; Harzallah, L; Hachfi, W; Slama, K Bel Hadj; Rammeh, N; Ghannouchi, M; Bahri, M; Letaief, A

    2005-09-01

    Despite their relative rarity, increased awareness of tuberculous sacro-iliitis is necessary. Indeed, diagnosis is usually delayed, because of the non specific clinical features and the difficulty to explore the sacro-iliac joint. To study the characteristics of sacro-iliac joint tuberculosis. A retrospective study of 22 cases of tuberculous sacro-iliitis collected between 1987 and 2003 in four university hospital centres. All our patients were explored clinically and radiologically. Microbiology, biochemical and serologic tests were also performed. 13 cases were confirmed bacteriologically or histologically and for the remaining nine cases evidence of tuberculous sacroiliitis was based on clinical, biological, radiological features and outcome on treatment. Inflammatory pain was present in almost all cases, and a collected abscess in 11 cases. Standard radiographs were also in all cases and ultrasound and CT scan showed an abscess in 8 patients. The average duration of treatment was nine months. The outcome was excellent in the majority of cases. Sacro-iliac joint is difficult to explore and has recently beneficiated of technical improvement in imaging and diagnostic. Medical treatment of tuberculosis sacro-iliitis is often sufficient.

  16. Twenty Years On!: Updating the IEA BESTEST Building Thermal Fabric Test Cases for ASHRAE Standard 140

    Energy Technology Data Exchange (ETDEWEB)

    Judkoff, R. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Neymark, J. [J. Neymark & Associates, Golden, CO (United States)

    2013-07-01

    ANSI/ASHRAE Standard 140, Standard Method of Test for the Evaluation of Building Energy Analysis Computer Programs applies the IEA BESTEST building thermal fabric test cases and example simulation results originally published in 1995. These software accuracy test cases and their example simulation results, which comprise the first test suite adapted for the initial 2001 version of Standard 140, are approaching their 20th anniversary. In response to the evolution of the state of the art in building thermal fabric modeling since the test cases and example simulation results were developed, work is commencing to update the normative test specification and the informative example results.

  17. A study of twenty-one cases of low-frequency noise complaints

    DEFF Research Database (Denmark)

    Pedersen, Christian Sejer; Møller, Henrik; Persson-Waye, Kerstin

    2008-01-01

    -frequency tinnitus. Noise recordings were made in the homes of the complainants, and the complainants were exposed to these in blind test listening experiments. Furthermore, the low-frequency hearing function of the complainants was investigated, and characteristics of the annoying sound was matched. The results...... showed that some of the complainants are annoyed by a physical sound (20-180 Hz), while others suffer from low-frequency tinnitus (perceived frequency 40-100 Hz). Physical sound at frequencies below 20 Hz (infrasound) is not responsible for the annoyance - or at all audible - in any of the investigated...... cases, and none of the complainants has extraordinary hearing sensitivity at low frequencies. For comparable cases of low-frequency noise complaints in general, it is anticipated that physical sound is responsible in a substantial part of the cases, while lowfrequency tinnitus is responsible in another...

  18. Ever since the first case report of HIV infection approximately twenty ...

    African Journals Online (AJOL)

    hi-tech

    concomitant post kala azar leishmaniasis (PKDL) in a female patient from a VL endemic district in Kenya is reported (2). Whereas it is known that PKDL (as the name suggests) only affects those who have previously suffered and been successfully treated for VL (3,4) in this case, the two clinical presentations i.e., the visceral.

  19. Educational Microcomputing at Home: A Comparative Case Analysis of Twenty Families with Children.

    Science.gov (United States)

    Giacquinta, Joseph B.

    This paper presents the first comparative findings emerging from 20 individual case studies into the adoption, use, and effects of microcomputers in families. The 20 families are first described according to a number of key demographic characteristics--socioeconomic, nationality, parent occupations, number and ages of children, etc. An examination…

  20. A case series of twenty one maternal filicides in the UK.

    Science.gov (United States)

    McKee, Amy; Egan, Vincent

    2013-10-01

    This study reports a case-series study of 21 women from the United Kingdom convicted of the murder or manslaughter of their child (maternal filicide: MF). These cases were reviewed using data provided from police forces and from publicly available resources. Content and thematic analysis and multidimensional scaling techniques were used to analyse the relationships between the variables present in the commission of the crimes. Mothers who killed their children could be categorised as emotionally driven and in despair at their situation, or rejecting their children due to perceiving them as a threat. Mothers who killed their babies (neonaticides) appeared to form two distinct subgroups: reluctant and detached neonaticidal offenders. These findings offer an insight into the factors that may be of relevance in understanding how a mother may come to commit MF, and are interpreted in terms of disturbed attachment processes. Copyright © 2013 Elsevier Ltd. All rights reserved.

  1. Twenty-four Years of Follow-Up for a Hanford Plutonium Wound Case

    Energy Technology Data Exchange (ETDEWEB)

    Carbaugh, Eugene H.; Lynch, Timothy P.; Antonio, Cheryl L.; Medina-Del Valle, Fernando

    2010-10-01

    A 1985 plutonium puncture wound resulted in the initial deposition of 48 kBq of transuranic alpha activity, primarily 239Pu and 241Am, in a worker’s right index finger. Surgical excisions in the week following reduced the long-term residual wound activity to 5.4 kBq, and 164 DTPA chelation therapy administrations over a 17-month period resulted in urinary excretion of about 7 kBq. The case was published in 1988, but now 20 additional years of follow-up data are available. Annual bioassay measurements have included wound counts, skeleton counts, liver counts, lung counts, axillary lymph node counts, and urinalyses for plutonium and 241Am. These measurements have shown relatively stable levels of 241Am at the wound site, with gradually increasing amounts of 241Am detected in the skeleton. Liver counts has shown erratic detection of 241Am, and lung counts indicate 241Am as shine from the axillary lymph nodes and skeleton. Urine excretion of 239Pu since termination of chelation therapy has typically ranged from 10 to 20 mBq d-1, with 241Am excretion being about 10% of that for 239Pu. In addition, the worker has undergone annual routine medical exams, which have not identified any adverse health effects associated with the intake.

  2. Drug-Induced Liver Injury: Twenty Five Cases of Acute Hepatitis Following Ingestion of Polygonum multiflorum Thunb

    Science.gov (United States)

    Jung, Kyoung Ah; Yoo, Seung Suk; Kim, Hong Jun; Choi, Su Nyoung; Ha, Chang Yoon; Kim, Hyun Jin; Kim, Tae Hyo; Jung, Woon Tae; Lee, Ok Jae; Lee, Jong Sil; Shim, Sang Goon

    2011-01-01

    Background/Aims Complementary medicines, including herbal preparations and nutritional supplements, are widely used without prescriptions. As a result, there has been growing interest in the risk of hepatotoxicity with these agents. It is difficult to determine causal relationships between these herbal preparations and hepatotoxicity. We report on 25 patients diagnosed with toxic hepatitis following ingestion of Polygonum multiflorum Thunb. Methods Twenty-five patients (median age, 48 years [24 to 65 years]; M:F=18:7) with suspected P. multiflorum Thunb-induced liver injury were admitted to our hospital between 2007 and 2009. We analyzed clinical and histological data, including the types and the duration of P. multiflorum Thunb intake and the duration of hospital care. We also determined the type of liver injury using the R ratio (serum activity of ALT/serum activity of ALP). Results The types of complementary medicine used included tea (n=16), liquor (n=5), tea and liquor (n=2), powder (n=1), and honeyed pudding (n=1). The most common presenting sign was jaundice (76%), and 18 patients (72%) had evidence of hepatocellular liver injury. Histological findings were consistent with acute hepatitis in all cases (n=10) for which liver biopsy was performed. Twenty-three patients (91.6%) recovered with conservative management, 1 patient (4%) had a liver transplant, and 1 patient (4%) died of hepatic failure. Conclusions In our cases, we found that P. multiflorum Thunb could be hepatotoxic and could lead to severe drug-induced liver injury, and even death. PMID:22195249

  3. Chapter Twenty

    African Journals Online (AJOL)

    User

    pictures of destitute, starving children, raped and battered women and cases of pollution. This is an indication that crime has taken over the society due to the economic situation of Delta state of Nigeria. ..... embark on education of his children so that they will not just have good jobs, but penetrate the oil companies in which ...

  4. Twenty-first century learning in schools: A case study of New Technology High School in Napa, California.

    Science.gov (United States)

    Pearlman, Bob

    2006-01-01

    The most pertinent question concerning teaching and learning in the twenty-first century is not what knowledge and skills students need--that laundry list was identified over a decade ago--but rather how to foster twenty-first century learning. What curricula, experiences, assessments, environments, and technology best support twenty-first century learning? New Technology High School (NTHS) in Napa, California, is one example of a successful twenty-first century school. In this chapter, the author describes the components of this exemplary high school, illustrating an environment that will cultivate twenty-first century student learning. New Technology High School began by defining eight learning outcomes, aligned with the standards of the Partnership for 21st Century Skills; to graduate, students demonstrate mastery of these outcomes through an online portfolio. To help students achieve the outcomes, NTHS employs project- and problem-based learning. Whereas in traditional classrooms students work alone on short-term assignments that do not lend themselves to deep understanding, the project-based learning approach has students working in teams on long-term, in-depth, rigorous projects. Students' work is supported by the school's workplace-like environment and effectiv use of technology. Meaningful assessment is essential to project-based learning; students receive continuous feedback, helping them become self-directed learners. In fact, NTHS uses outcome-based grading through which students constantly know how they are performing on the twenty-first century outcomes. Research has shown that NTHS graduates are better prepared for postsecondary education, careers, and citizenship than their peers from other schools. To facilitate twenty-first century learning, all schools need to rethink their approach to teaching and learning. New Technology High School is one way to do so.

  5. Preparing the Twenty-First Century Workforce: The Case of Curriculum Change in Radiation Protection Education in the United States

    Science.gov (United States)

    Schmidt, Matthew; Easter, Matthew; Jonassen, David; Miller, William; Ionas, Gelu

    2008-01-01

    The advent of the global information society and a myriad of other rapidly changing variables are presenting many new and unique challenges for the twenty-first century workforce, and perhaps the most pressing of these challenges is actually meeting the needs for qualified workers to fill the positions in emerging and growing fields. One such…

  6. Transformative Pedagogy, Leadership and School Organisation for the Twenty-First-Century Knowledge-Based Economy: The Case of Singapore

    Science.gov (United States)

    Dimmock, Clive; Goh, Jonathan W. P.

    2011-01-01

    Singapore has a high performing school system; its students top international tests in maths and science. Yet while the Singapore government cherishes its world class "brand", it realises that in a globally competitive world, its schools need to prepare students for the twenty-first-century knowledge-based economy (KBE). Accordingly,…

  7. Twenty Years On!: Updating the IEA BESTEST Building Thermal Fabric Test Cases for ASHRAE Standard 140: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Judkoff, R.; Neymark, J.

    2013-07-01

    ANSI/ASHRAE Standard 140, Standard Method of Test for the Evaluation of Building Energy Analysis Computer Programs applies the IEA BESTEST building thermal fabric test cases and example simulation results originally published in 1995. These software accuracy test cases and their example simulation results, which comprise the first test suite adapted for the initial 2001 version of Standard 140, are approaching their 20th anniversary. In response to the evolution of the state of the art in building thermal fabric modeling since the test cases and example simulation results were developed, work is commencing to update the normative test specification and the informative example results.

  8. Twenty two cases of canine neural angiostronglyosis in eastern Australia (2002-2005 and a review of the literature

    Directory of Open Access Journals (Sweden)

    Lunn Julian A

    2012-04-01

    Full Text Available Abstract Cases of canine neural angiostrongylosis (NA with cerebrospinal fluid (CSF evaluations in the peer-reviewed literature were tabulated. All cases were from Australia. A retrospective cohort of 59 dogs was contrasted with a series of 22 new cases where NA was diagnosed by the presence of both eosinophilic pleocytosis and anti-Angiostrongylus cantonensis immunloglobulins (IgG in CSF, determined by ELISA or Western blot. Both cohorts were drawn from south east Queensland and Sydney. The retrospective cohort comprised mostly pups presented for hind limb weakness with hyperaesthesia, a mixture of upper motor neurone (UMN and lower motor neurone (LMN signs in the hind limbs and urinary incontinence. Signs were attributed to larval migration through peripheral nerves, nerve roots, spinal cord and brain associated with an ascending eosinophilic meningo-encephomyelitis. The contemporary cohort consisted of a mixture of pups, young adult and mature dogs, with a wider range of signs including (i paraparesis/proprioceptive ataxia (ii lumbar and tail base hyperaesthesia, (iii multi-focal central nervous system dysfunction, or (iv focal disease with neck pain, cranial neuropathy and altered mentation. Cases were seen throughout the year, most between April and July (inclusive. There was a preponderance of large breeds. Often littermates, or multiple animals from the same kennel, were affected simultaneously or sequentially. A presumptive diagnosis was based on consistent signs, proximity to rats, ingestion/chewing of slugs or snails and eosinophilic pleocytosis. NA was diagnosed by demonstrating anti-A. cantonensis IgG in CSF. Detecting anti-A. cantonensis IgG in serum was unhelpful because many normal dogs (20/21 lb dogs; 8/22 of a hospital population had such antibodies, often at substantial titres. Most NA cases in the contemporary series (19/22 and many pups (16/38 in the retrospective cohort were managed successfully using high doses of

  9. Anchor suture fixation of distal pole fractures of patella: twenty seven cases and comparison to partial patellectomy.

    Science.gov (United States)

    Kadar, Assaf; Sherman, Haggai; Drexler, Michael; Katz, Eldad; Steinberg, Ely L

    2016-01-01

    Partial patellectomy (PP) and reattachment of the patellar ligament with transosseous suturing is the mainstay of surgical treatment for distal pole patellar fractures. An anchor suturing (AS) technique has recently been reported as an alternative to PP in such fractures and allows for bone-to-bone interface and possibly superior fracture healing than bone-to-tendon interface with PP. We present our experience with AS and compare it to PP. Between 2006 and 2011, 60 patients with distal pole patellar fracture underwent either AS (n = 27) or PP (n = 33). We retrospectively gathered their demographic data and information on fracture type, fixation technique, operation time, postoperative complications and knee range of motion. A telephone survey was performed to grade functional outcomes with standard questionnaires (the SF-12 for quality of life, the Kujala score for patellofemoral function and a visual analog scale [VAS] pain score). AS was equivalent to PP in terms of residual pain and functional outcomes (VAS: 2.45 vs. 2.26, p = 0.83 and Kujala score: 74.3 vs. 69, p = 0.351, respectively) as well as for knee range of motion. Complications included three cases of infection in each group, two cases of early hardware failure and one case of non-union in the AS group. Operation time was significantly shorter for AS compared to PP (68.5 vs. 79.1 min, p = 0.03). AS is non-inferior to PP for function and pain after distal pole patellar fractures and is superior to PP with regard to operative time. Common complications of this technique are hardware failure and infections. Therapeutic Level III.

  10. Benign monomelic amyotrophy: a study of twenty-one cases Amiotrofia monomélica benigna: estudo de 21 casos

    Directory of Open Access Journals (Sweden)

    MARCOS R.G. DE FREITAS

    2000-09-01

    Full Text Available A consecutive series of 21 patients with single limb atrophy (monomelic amyotrophy is reported. Sixteen had lower limb atrophy and five had upper limb involvement. The median age of the onset was 20 years. Characteristic features were sporadic occurrence, wasting confined to one limb, insidious onset with slow progression, stabilizing in 1 to 4 years, and absence of pyramidal signs. All the patients with upper limb involvement were male, however in our cases with lower limb amyotrophy there were no male preponderance. We observed wasting of the entire length of the lower limbs in six patients. There were nine cases with amyotrophy restricted to the leg and one with amyotrophy only in the thigh. In the upper limb in four cases the involvement was distal and in one patient the atrophy was proximal. The electromyographic features were suggestive of anterior horn disease not only in the affected limb but also, in some cases, in clinically uninvolved limb. Cervical or lumbar MRI was normal. MRI of the lower limb disclosed increased signal intensity in the gastrocnemius and soleus muscles in one patient suggesting denervation.Relatamos uma série consecutiva de 21 pacientes com amiotrofia de um só membro, denominada de amiotrofia monomélica. Em 16 casos a atrofia era no membro inferior e em 5 localizava-se no membro superior. Todos eram jovens e a idade média do início foi 20 anos. Os dados mais característicos da doença foram ausência de história familiar, comprometimento de um só membro, início e progressão lenta estabilizando em até 4 anos e ausência de sinais piramidais. Nossos enfermos com amiotrofia de membro superior eram todos do sexo masculino, entretanto naqueles com amiotrofia do membro inferior havia igualdade de sexos. Dos pacientes com atrofia de membro inferior, em 9 a atrofia era restrita a perna, em 6 era em todo o membro e somente um apresentava amiotrofia localizada só na coxa. Naqueles com comprometimento do membro

  11. Transient Epileptic Amnesia over twenty years: Long-term follow-up of a case series with three detailed reports.

    Science.gov (United States)

    Savage, Sharon A; Butler, Christopher R; Hodges, John R; Zeman, Adam Z

    2016-12-01

    Transient Epileptic Amnesia (TEA) is a form of adult onset temporal lobe epilepsy characterised by ictal amnesia. The amnesic seizures are often accompanied by interical memory disturbance, involving autobiographical amnesia and accelerated long-term forgetting. Short-term follow-up studies suggest a relatively stable cognitive profile once treated, but recent case reports raise concerns regarding the risk of developing Alzheimer's disease (AD). The current study reports clinical and cognitive outcome in TEA patients over a 20-year period. A cohort of ten TEA patients first reported in 1998 were followed up at two time intervals, each 10 years apart. Information regarding clinical outcomes and subjective reports of memory functioning was gained via GP records and clinical interview. Objective memory function was determined at each time point via a comprehensive neuropsychological assessment, where possible. Information was obtained for nine of the original 10 participants. Over the 20-year period, 4 participants died, with no indication of dementia prior to death. One participant was diagnosed with Vascular Dementia. Seizures were generally well controlled. Subjective reports of memory varied, including no concerns, stable memory difficulties, and worsening memory. Neuropsychological assessment at 10 years showed stable performances across most measures. At the 20-year follow up, there was no evidence of a general cognitive decline. Participants showed stability on some measures, with reductions on others. Performance was not consistent with AD. No elevated risk of dementia was evident from this TEA series. Although memory difficulties persist over time, the prognosis of TEA appears generally benign. Copyright © 2016 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

  12. Traces of Ideology in Translating the Qurān into English: A Critical Discourse Analysis of Six Cases across Twenty Versions

    Directory of Open Access Journals (Sweden)

    Abdunasir I. A. Sideeg

    2015-09-01

    Full Text Available This research article aims to explore and critically examine six cases in which traces of ideology are explicitly or implicitly involved in the context of translating the Qurān into English. It attempts to answer questions pertinent to the nature and effect of traces of ideology on translating the Qurān in English and the way they shape the Qurānic message. The article employs a critical qualitative framework that allows for the researcher’s subjective interpretations of relevant texts. Critical Discourse Analysis (CDA is used for the analysis of data as this approach provides a convenient mode of critical thinking to carry out the present thesis. In this article, six texts across twenty versions of the Qurān in English are investigated in terms of their salient features that reflect peculiar ideological readings. Major findings indicate that complex traces of ideology may contribute to a particular choice in translating the salient features in the texts investigated. The case of Helminski, for instance, shows how cultural and linguistic backgrounds, Sufi doctrines, and feminist agendas all combine to produce a radical reading of the Qurān in English where she consistently refers to Allah (SWT with the combination he/she. Sufi ideologies are crucial in translating some pronouns with controversial references in some Qurānic verses. As well, gnostic interpretations have their own legacy such as the alteration in Khalifa’s ‘authorized version’. Plus, Neo-Mutazilite and Qurānist traces of ideology significantly contribute to produce alien readings of some Qurānic texts as illustrated in cases (5 and (6 in this research article.

  13. Historical Approach to the Role of Women in the Legislation of Iran: A Case Study on the Twenty-First Parliament

    Directory of Open Access Journals (Sweden)

    Sarah Sheibani

    2017-01-01

    Full Text Available One hundred and ten years ago, men and women took constitutionalism to achieve justice in Iran. National Council was the result of the Iranian people's struggle for justice, both women and men. Men policies from the beginning of legislation put women as minors and lunatics and bankrupted and banned them from vote. However, the Constitutional Revolution as a turning point and a national revolution played a key role in changing attitudes to women and structural context of their participation provided. In this paper, with the use of descriptive-analytical as well as quantitative methods, we sought to answer the question that what was the position of women in the twenty-first Parliament. The results of this study suggest that when Iranian women were allowed to participate politics, they have achieved to show their ability in politics as we saw examples in the twenty-first Parliament in which women had twenty-two percent participation.

  14. Twenty lectures on thermodynamics

    CERN Document Server

    Buchdahl, H A

    2013-01-01

    Twenty Lectures on Thermodynamics is a course of lectures, parts of which the author has given various times over the last few years. The book gives the readers a bird's eye view of phenomenological and statistical thermodynamics. The book covers many areas in thermodynamics such as states and transition; adiabatic isolation; irreversibility; the first, second, third and Zeroth laws of thermodynamics; entropy and entropy law; the idea of the application of thermodynamics; pseudo-states; the quantum-static al canonical and grand canonical ensembles; and semi-classical gaseous systems. The text

  15. A Conservation Ethic and the Collecting of Animals by Institutions of Natural Heritage in the Twenty-First Century: Case Study of the Australian Museum

    Science.gov (United States)

    Ikin, Timothy

    2011-01-01

    Simple Summary It is a core task of collecting institutions like museums to take examples of animals and preserve them as specimens in collections. In the twenty-first century, museums are equally the places where research is conducted and education is promoted in the service of conservation of animals in an era of the decline of biodiversity. In this paper, the balance of co-operation between collecting of animals by museums and the promotion and scientific pursuit of conservation of fauna in those museums is considered. As a “challenge” to museum science, it is considered in the context of Australia's oldest museum, and its policy and practice in the current century. Abstract Collecting of animals from their habitats for preservation by museums and related bodies is a core operation of such institutions. Conservation of biodiversity in the current era is a priority in the scientific agendas of museums of natural heritage in Australia and the world. Intuitively, to take animals from the wild, while engaged in scientific or other practices that are supposed to promote their ongoing survival, may appear be incompatible. The Australian Museum presents an interesting ground to consider zoological collecting by museums in the twenty-first century. Anderson and Reeves in 1994 argued that a milieu existed that undervalued native species, and that the role of natural history museums, up to as late as the mid-twentieth century, was only to make a record the faunal diversity of Australia, which would inevitably be extinct. Despite the latter, conservation of Australia's faunal diversity is a key aspect of research programmes in Australia's institutions of natural heritage in the current era. This paper analyses collecting of animals, a core task for institutions of natural heritage, and how this interacts with a professed “conservation ethic” in a twenty-first century Australian setting. PMID:26486222

  16. A Conservation Ethic and the Collecting of Animals by Institutions of Natural Heritage in the Twenty-First Century: Case Study of the Australian Museum.

    Science.gov (United States)

    Ikin, Timothy

    2011-02-15

    Collecting of animals from their habitats for preservation by museums and related bodies is a core operation of such institutions. Conservation of biodiversity in the current era is a priority in the scientific agendas of museums of natural heritage in Australia and the world. Intuitively, to take animals from the wild, while engaged in scientific or other practices that are supposed to promote their ongoing survival, may appear be incompatible. The Australian Museum presents an interesting ground to consider zoological collecting by museums in the twenty-first century. Anderson and Reeves in 1994 argued that a milieu existed that undervalued native species, and that the role of natural history museums, up to as late as the mid-twentieth century, was only to make a record the faunal diversity of Australia, which would inevitably be extinct. Despite the latter, conservation of Australia's faunal diversity is a key aspect of research programmes in Australia's institutions of natural heritage in the current era. This paper analyses collecting of animals, a core task for institutions of natural heritage, and how this interacts with a professed "conservation ethic" in a twenty-first century Australian setting.

  17. A unique presentation of renal cell transformation into renal cell carcinoma in subcutaneous fatty tissue post twenty year old healing gun-shot wound: A case report

    Directory of Open Access Journals (Sweden)

    Awadh R. Alqahtani

    2017-01-01

    Conclusion: The authors have reported an interesting case of an RCC presenting in a healed gun-shot wound in a previously nephrectomized patient. To the best of authors’ knowledge, such a case hasn’t been reported in the literature before, with it being unique in its time course, preceding events, and absence of primary lesions.

  18. Top at Twenty

    CERN Document Server

    2015-01-01

    The "Top at Twenty" workshop is dedicated to the celebration of 20 years since the top quark discovery at Fermilab in 1995. Speakers from all experiments capable of studying top quark, ATLAS, CDF, CMS and DZero, will present the most recent results of the top quark studies based on Run II of the Tevatron and Run I of the LHC. Reviews of such fundamental measurements as mass of the top quark, its spin, charge and production properties are planned with some of them orders of magnitude better in precision in comparison with original CDF and DZero papers announcing the top quark discovery. Measurements of top quark production and decay that illuminate the nature of the Higgs boson and seek new phenomena will be presented. Theoretical talks on how the top quark fits into the Standard Model and its potential extensions will also be presented. This workshop will complement the yearly Top Workshop which is held in September and will benefit from many new results expected to be presented at winter conferences in 2015...

  19. [Twenty-two months old girl with haemorrhagic gastritis as a complication after the nonsteroid anti-inflammatory drugs application--case report].

    Science.gov (United States)

    Mierzwa, Grazyna; Jakubczyk, Marlena; Parzecka, Monika; Swincow, Grazyna; Popławski, Cezary

    2008-01-01

    The aim of case report was to pay attention for possibility of side effects of nonsteroid anti-inflammatory drugs. Child of young and healthy parents was born after normal pregnancy, natural delivery. The disease started in two days before the admission, child had fever, cough and sneezing. Mother gave her two doses of ibuprofen. On the time of admission general state of patient was moderate; girl was apathic. In physical examination features of upper respiratory tract infection were shown. In the course of treatment antibiotic and symptomatic drugs including paracetamol (3x5 ml) were delivered. During the second day of treatment child had no appetite, started to vomit with fresh and haemolized blood. Parenteral hydratation was started. Emergency gastroscopy was done and features of haemorrhagic gastritis were shown. Anti-inflammatory drugs were no more used and delivery of omeprazole was started. Parenteral hydratation was continued. General state of patient was better. In the sixth day after bleeding child was excripted in good general state with order of use of omeprazole. Parents were informed about the restriction of anti-inflammatory drugs use. The aim of case report was to pay attention that haemorrhagic gastritis may be one of side effects of nonsteroid anti-inflammatory drugs used accordingly to actual standards.

  20. Outlook: The Next Twenty Years

    Energy Technology Data Exchange (ETDEWEB)

    Murayama, Hitoshi

    2003-12-07

    I present an outlook for the next twenty years in particle physics. I start with the big questions in our field, broken down into four categories: horizontal, vertical, heaven, and hell. Then I discuss how we attack the bigquestions in each category during the next twenty years. I argue for a synergy between many different approaches taken in our field.

  1. Twenty-first century vaccines

    Science.gov (United States)

    Rappuoli, Rino

    2011-01-01

    In the twentieth century, vaccination has been possibly the greatest revolution in health. Together with hygiene and antibiotics, vaccination led to the elimination of many childhood infectious diseases and contributed to the increase in disability-free life expectancy that in Western societies rose from 50 to 78–85 years (Crimmins, E. M. & Finch, C. E. 2006 Proc. Natl Acad. Sci. USA 103, 498–503; Kirkwood, T. B. 2008 Nat. Med 10, 1177–1185). In the twenty-first century, vaccination will be expected to eliminate the remaining childhood infectious diseases, such as meningococcal meningitis, respiratory syncytial virus, group A streptococcus, and will address the health challenges of this century such as those associated with ageing, antibiotic resistance, emerging infectious diseases and poverty. However, for this to happen, we need to increase the public trust in vaccination so that vaccines can be perceived as the best insurance against most diseases across all ages. PMID:21893537

  2. The characterization of twenty sequenced human genomes.

    Directory of Open Access Journals (Sweden)

    Kimberly Pelak

    2010-09-01

    Full Text Available We present the analysis of twenty human genomes to evaluate the prospects for identifying rare functional variants that contribute to a phenotype of interest. We sequenced at high coverage ten "case" genomes from individuals with severe hemophilia A and ten "control" genomes. We summarize the number of genetic variants emerging from a study of this magnitude, and provide a proof of concept for the identification of rare and highly-penetrant functional variants by confirming that the cause of hemophilia A is easily recognizable in this data set. We also show that the number of novel single nucleotide variants (SNVs discovered per genome seems to stabilize at about 144,000 new variants per genome, after the first 15 individuals have been sequenced. Finally, we find that, on average, each genome carries 165 homozygous protein-truncating or stop loss variants in genes representing a diverse set of pathways.

  3. HDECAY: Twenty++ Years After arXiv

    CERN Document Server

    Djouadi, Abdelhak; Muehlleitner, Margarete; Spira, Michael

    The program HDECAY determines the partial decay widths and branching ratios of the Higgs bosons within the Standard Model with three and four generations of fermions, including the case when the Higgs couplings are rescaled, a general two--Higgs doublet model where the Higgs sector is extended and incorporates five physical states and its most studied incarnation, the minimal supersymmetric Standard Model (MSSM). The program addresses all decay channels including the dominant higher-order effects such as radiative corrections and multi-body channels. Since the first launch of the program, more than twenty years ago, important aspects and new ingredients have been incorporated. In this update of the program description, some of the developments are summarized while others are discussed in some detail.

  4. Cancer incidence in the population exposed to dioxin after the "Seveso accident": twenty years of follow-up

    Directory of Open Access Journals (Sweden)

    Rubagotti Maurizia

    2009-09-01

    Full Text Available Abstract Background The Seveso, Italy accident in 1976 caused the contamination of a large population by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD. Possible long-term effects have been examined through mortality and cancer incidence studies. We have updated the cancer incidence study which now covers the period 1977-96. Methods The study population includes subjects resident at the time of the accident in three contaminated zones with decreasing TCDD soil levels (zone A, very high; zone B, high; zone R, low and in a surrounding non-contaminated reference territory. Gender-, age-, and period-adjusted rate ratios (RR and 95% confidence intervals (95% CI were calculated by using Poisson regression for subjects aged 0-74 years. Results All cancer incidence did not differ from expectations in any of the contaminated zones. An excess of lymphatic and hematopoietic tissue neoplasms was observed in zones A (four cases; RR, 1.39; 95% CI, 0.52-3.71 and B (29 cases; RR, 1.56; 95% CI, 1.07-2.27 consistent with the findings of the concurrent mortality study. An increased risk of breast cancer was detected in zone A females after 15 years since the accident (five cases, RR, 2.57; 95% CI, 1.07-6.20. No cases of soft tissue sarcomas occurred in the most exposed zones (A and B, 1.17 expected. No cancer cases were observed among subjects diagnosed with chloracne early after the accident. Conclusion The extension of the Seveso cancer incidence study confirmed an excess risk of lymphatic and hematopoietic tissue neoplasms in the most exposed zones. No clear pattern by time since the accident and zones was evident partly because of the low number of cases. The elevated risk of breast cancer in zone A females after 15 years since the accident deserves further and thorough investigation. The follow-up is continuing in order to cover the long time period (even decades usually elapsing from exposure to carcinogenic chemicals and disease occurrence.

  5. Capital in the Twenty-First Century

    DEFF Research Database (Denmark)

    Hansen, Per H.

    2014-01-01

    Review essay on: Capital in the Twenty-First Century. By Thomas Piketty . Translated by Arthur Goldhammer . Cambridge, Mass.: The Belknap Press of Harvard University Press, 2014. viii + 685 pp......Review essay on: Capital in the Twenty-First Century. By Thomas Piketty . Translated by Arthur Goldhammer . Cambridge, Mass.: The Belknap Press of Harvard University Press, 2014. viii + 685 pp...

  6. Brain tumors in the first three years of life: a review of twenty cases Tumores do sistema nervoso central nos primeiros três anos de vida: revisão de vinte casos

    Directory of Open Access Journals (Sweden)

    Adriana Ávila de Espíndola

    2007-12-01

    Full Text Available OBJECTIVE AND METHOD: To review the clinical and neuropathological findings as well as the type of therapy and outcome in 20 infants under 3 years-old with central nervous system (CNS tumor. They were treated at the Department of Neurology, "Hospital das Clínicas" University of São Paulo Medical School, from January 1997 to May 2001. RESULTS: Astrocytoma was the most common histological type (n=7, followed by ependymoma (n=3, medulloblastoma (n=2, craniopharyngioma (n=2 and desmoplastic ganglioglioma (n=2. The location of the tumor was predominantly supratentorial. Mean follow-up time was 20.2 months with recurrence in 7 cases. For each type of tumor we have emphasized the treatment currently recommended. CONCLUSION: Although follow-up time is not sufficient for analyzing survival, a trend of improvement in prognosis was noted, compared to another series of cases from our Institution that had been evaluated before 1990.OBJETIVO E MÉTODO: Avaliar os aspectos clínicos e histopatológicos, o tipo de tratamento e a evolução de 20 crianças menores de três anos de idade, com o diagnóstico de tumor de sistema nervoso central, que foram tratadas em nossa Instituição no período de janeiro de 1997 a maio de 2001. RESULTADOS: O astrocitoma foi o tumor mais comum (n=7, seguido pelo ependimoma (n=3, meduloblastoma (n=2, craniofaringioma (n=2 e ganglioglioma desmoplásico infantil (n=2. A localização do tumor foi predominantemente supratentorial. A média de seguimento foi 20,2 meses e houve recidiva em sete casos. Para cada tipo de tumor enfatizamos o tipo de tratamento recomendado na atualidade. CONCLUSÃO: Embora o tempo de seguimento não seja suficiente, ainda, para analisar a sobrevida, foi notada nítida tendência a melhor prognóstico em comparação com a casuística proviniente de nossa Instituição que analisou casos abordados antes da década de 90.

  7. IRVINGIA GABONENSIS FOR TWENTY-FOUR WEEKS

    African Journals Online (AJOL)

    Bark Extracts oflrvingia Gubonensis For Twenty-four eeI

  8. The Twenty Statement Test in Teacher Development

    Directory of Open Access Journals (Sweden)

    Ahmet Aypay

    2011-04-01

    Full Text Available The purpose of this study is to describe teacher characteristics using Twenty Statements Test (TST. Study group includes a total of thirty-five individuals, including teachers, guidance and counselors and research assistants. The study used a qualitative approach on teacher identity. TST is one of the qualitative methods that were used to determine individual self-conceptualization. Study group were requested to write twenty statements that describe themselves responding to the question “Who I am?” in a free format. The findings indicated that teachers were overwhelmingly in group c (reflective. No differences were found in terms of gender and profession. Only few significant differences have been found based on marital status. The utility of TST in teacher training and development was discussed

  9. The Twenty Statement Test in Teacher Development

    Directory of Open Access Journals (Sweden)

    Ahmet Aypay

    2011-10-01

    Full Text Available The purpose of this study is to describe teacher characteristics using Twenty Statements Test (TST. Study group includes a total of thirty-five individuals, including teachers, guidance and counselors and research assistants. The study used a qualitative approach on teacher identity. TST is one of the qualitative methods that were used to determine individual self-conceptualization. Study group were requested to write twenty statements that describe themselves responding to the question “Who I am?” in a free format. The findings indicated that teachers were overwhelmingly in group c (reflective. No differences were found in terms of gender and profession. Only few significant differences have been found based on marital status. The utility of TST in teacher training and development was discussed.

  10. Intelligence in the Twenty-First Century

    OpenAIRE

    Shebarshin, Leonid V.

    2000-01-01

    The author concludes that the world will most probably remain rife with conflict even in the twenty first century and that the traditional role of intelligence will not only continue but will increase in importance. He characterizes the international situation as being "more of the same historically"; that is, the existence of several different centers of power and mutual conflicts based solely on national interests. In order to protect and promote one's national interests, sovereign states w...

  11. Notional syllabuses : twenty one years on

    OpenAIRE

    Hurst, Nicolas

    1997-01-01

    This paper sets out to reappraise the original 1976 book entitled "Notional Syllabuses" by D.A.Wilkins on the advent of the twenty-first anniversary of its publication. An outline and personal assessment of the content of the book are presented in the light of more recent developments in methodological approaches to T.E.F.L., more specifically with reference to Communicative Language Teaching.

  12. Twenty cases of equine osteoarthrosis detected at autopsy.

    Science.gov (United States)

    Ohshima, K; Satake, S; Ono, M; Ajito, T; Okada, K; Numakunai, S

    1990-02-01

    A pathological study was performed on osteoarthrosis detected at autopsy in 20 horses whose ages ranged from 21 days to 17 years old. They were asymptomatic on the joints except in 3 animals, and autopsied after death or sacrificed due to accidental fracture or other diseases. Lesions of osteoarthrosis were recognized in all horses, which tended to increase in incidence and severity according to age. Lesions were concentrated at hinged joints such as the elbow, fetlock, and hock. Synovial fossae and ulcerative lesions were observed on each opposite articular cartilage, forming the so-called mirror image. Linear erosions regarded as a secondary one were frequently observed on the cartilages. Histologically, the lesions were classified into 4 phases, 1) edematous degeneration, 2) crevice formation, focal necrosis, erosion of cartilage, 3) ulcerative changes, 4) regenerative changes of cartilage in foals and proliferation of fibrous or adipose tissue on the denuded subchondral bone in aged horses. By toluidine blue stain, decreased acid mucopolysaccharide was suggested in cartilaginous matrix around the lesions. From the results, it was concluded that the disease was a disorder of articular cartilage accompanied with hypoplasia of articular subchondral bone.

  13. Twenty-two cases of low-frequency noise complaints

    DEFF Research Database (Denmark)

    Pedersen, Christian Sejer; Møller, Henrik; Persson-Waye, Kerstin

    2006-01-01

    can only be heard by a single person in the household, and if measurements are performed the authorities cannot find any noise exceeding the existing limits for noise. This raises the fundamental question whether the complainants are annoyed by an external physical sound, or if other explanations must...... were measured. In a blind test it was examined if they are able to hear the sound recorded in their homes. Details from noise recordings, analysis and the experimental design are presented, however, since the experiments were finishing at the time of paper submission no results are presented...

  14. Twenty years of bacterial genome sequencing.

    Science.gov (United States)

    Loman, Nicholas J; Pallen, Mark J

    2015-12-01

    Twenty years ago, the publication of the first bacterial genome sequence, from Haemophilus influenzae, shook the world of bacteriology. In this Timeline, we review the first two decades of bacterial genome sequencing, which have been marked by three revolutions: whole-genome shotgun sequencing, high-throughput sequencing and single-molecule long-read sequencing. We summarize the social history of sequencing and its impact on our understanding of the biology, diversity and evolution of bacteria, while also highlighting spin-offs and translational impact in the clinic. We look forward to a 'sequencing singularity', where sequencing becomes the method of choice for as-yet unthinkable applications in bacteriology and beyond.

  15. The twenty-first century in space

    CERN Document Server

    Evans, Ben

    2015-01-01

    This final entry in the History of Human Space Exploration mini-series by Ben Evans continues with an in-depth look at the latter part of the 20th century and the start of the new millennium. Picking up where Partnership in Space left off, the story commemorating the evolution of manned space exploration unfolds in further detail. More than fifty years after Yuri Gagarin’s pioneering journey into space, Evans extends his overview of how that momentous voyage continued through the decades which followed. The Twenty-first Century in Space, the sixth book in the series, explores how the fledgling partnership between the United States and Russia in the 1990s gradually bore fruit and laid the groundwork for today’s International Space Station. The narrative follows the convergence of the Shuttle and Mir programs, together with standalone missions, including servicing the Hubble Space Telescope, many of whose technical and human lessons enabled the first efforts to build the ISS in orbit. The book also looks to...

  16. Inexpensive Complex Hand Model Twenty Years Later.

    Science.gov (United States)

    Frenger, Paul

    2015-01-01

    Twenty years ago the author unveiled his inexpensive complex hand model, which reproduced every motion of the human hand. A control system programmed in the Forth language operated its actuators and sensors. Follow-on papers for this popular project were next presented in Texas, Canada and Germany. From this hand grew the author’s meter-tall robot (nicknamed ANNIE: Android With Neural Networks, Intellect and Emotions). It received machine vision, facial expressiveness, speech synthesis and speech recognition; a simian version also received a dexterous ape foot. New artificial intelligence features included op-amp neurons for OCR and simulated emotions, hormone emulation, endocannabinoid receptors, fear-trust-love mechanisms, a Grandmother Cell recognizer and artificial consciousness. Simulated illnesses included narcotic addiction, autism, PTSD, fibromyalgia and Alzheimer’s disease. The author gave 13 robotics-AI presentations at NASA in Houston since 2006. A meter-tall simian robot was proposed with gripping hand-feet for use with space vehicles and to explore distant planets and moons. Also proposed were: intelligent motorized exoskeletons for astronaut force multiplication; a cognitive prosthesis to detect and alleviate decreased crew mental performance; and a gynoid robot medic to tend astronauts in deep space missions. What began as a complex hand model evolved into an innovative robot-AI within two decades.

  17. Twenty Years After: Armenian Research Libraries Today

    Directory of Open Access Journals (Sweden)

    D. Aram Donabedian

    2012-05-01

    Full Text Available Since achieving statehood in 1991, Armenia has faced major economic and political obstacles which have significantly affected the nation’s research libraries. This research paper will quantitatively and qualitatively examine the challenges facing Armenian research libraries just over twenty years after the collapse of the Soviet Union. Specifically, the authors analyze their interviews with five library administrators at five major institutions, respectively. These include Yerevan State University Library, the National Library of Armenia, the Fundamental Scientific Library of the National Academy of Sciences of Armenia, the Republican Scientific-Medical Library of Armenia, and the Papazian Library of the American University of Armenia. The instrument for the interviews consists of 73 questions based on the 2004 Association of College and Research Libraries Standards for Libraries in Higher Education and evaluates the following factors:• The library’s mission, goals and objectives• Public or user services• Instruction activities at the library• Resources (print, media, or electronic and collection development• Access to the library’s resources• Outcome assessment, or evaluation of the library• Staffing issues• Facility maintenance and plans for library development• Communication and cooperation both within the library and with the user community• Administration• BudgetIn addition, we will focus on the strengths and weaknesses of these libraries and investigate the growing open access movement in Armenia. Based on our findings, the authors wish to facilitate dialogue and consider possible approaches to help these libraries meet Armenia’s pressing information needs.

  18. Twenty Practices of an Entrepreneurial University

    DEFF Research Database (Denmark)

    Gjerding, Allan Næs; Wilderom, Celeste P.M.; Cameron, Shona P.B.

    2006-01-01

    of an entrepreneurial university, and by decreasing levels of state funding for universities, we undertook a study on four very active ECIU universities (ECIU = European Consortium of Innovative Universities, www.eciu.org). To evaluate and quantify their level of entrepreneurship, we extracted from Burton Clark's case...

  19. Twenty-First-Century Aerial Mining

    Science.gov (United States)

    2015-04-01

    with little opposition (Anzio, Inchon, and Suez ), the follow- up delivery of reinforcements and materiel is essential. In an environ- ment where... 1956 ), chap. 5, http://nzetc.victoria.ac.nz/tm/scholarly/tei-WH2-2RAF-c5.html. 4. Chilstrom, Mines Away!, 25. 5. Ibid., 21. 6. Ibid., 22. 7. Ibid...in Crisis : The Case of the River Danube” (paper presented at the International Association of Maritime Economists 2002 Conference Proceed- ings

  20. Proceedings: Twenty years of energy policy: Looking toward the twenty-first century

    Energy Technology Data Exchange (ETDEWEB)

    1992-12-31

    In 1973, immediately following the Arab Oil Embargo, the Energy Resources Center, University of Illinois at Chicago initiated an innovative annual public service program called the Illinois Energy Conference. The objective was to provide a public forum each year to address an energy or environmental issue critical to the state, region and nation. Twenty years have passed since that inaugural program, and during that period we have covered a broad spectrum of issues including energy conservation nuclear power, Illinois coal, energy policy options, natural gas, alternative fuels, new energy technologies, utility deregulation and the National Energy Strategy.

  1. Twenty years on: Poverty and hardship in urban Fiji

    Directory of Open Access Journals (Sweden)

    Jenny Bryant-Tokalau

    2012-09-01

    Full Text Available Through ‘official statistics’, academic and donor interpretations as well as the eyes of Suva residents, this paper presents an overview and case study of twenty years of growing poverty and hardship in the contemporary Pacific. Focusing on the past two decades, the paper notes how much, and yet so little, has changed for those attempting to make a living in the rapidly developing towns and cities. Changing interpretations of poverty and hardship are presented, moving from the ‘no such thing’ view, to simplification, and finally to an understanding that Pacific island countries, especially Fiji, are no longer an ‘extension’ of Australia and New Zealand, but independent nations actively trying to find solutions to their issues of economic, social and political hardship whilst facing challenges to traditional institutions and networks. Fiji is in some respects a very particular case as almost half of the population has limited access to secure land, but the very nature of that vulnerability to hardship and poverty holds useful lessons for wider analysis.

  2. Mobile Experiences of an Adolescent Learning Spanish Online in a Twenty-First Century High School

    Science.gov (United States)

    Tochon, Francois Victor

    2015-01-01

    This article focuses on a case analysis based on the experience of an adolescent having to further Spanish learning through the Spanish 3 (third year) distance course of a twenty-first century high school program. Autoethnographic reflections mediate the storyline of the experiential report, as conversations and observations are internalized by…

  3. An analysis of players\\' performances in the first cricket Twenty20 ...

    African Journals Online (AJOL)

    The purpose of this paper is to show how batting and bowling performance measures for one-day internationals can be adapted for use in Twenty20 matches, specifically in the case of a very small number of matches played. These measures are then used to give rankings of the batsmen and bowlers who performed best in ...

  4. 24 CFR 1710.9 - Twenty acre lots.

    Science.gov (United States)

    2010-04-01

    ... DEVELOPMENT (INTERSTATE LAND SALES REGISTRATION PROGRAM) LAND REGISTRATION General Requirements § 1710.9 Twenty acre lots. (a) The sale of lots in a subdivision is exempt from the registration requirements of...

  5. Strategic Leader Competencies for the Twenty-First Century

    National Research Council Canada - National Science Library

    Becker, Bradley A

    2007-01-01

    ...: interpersonal skills, conceptual skills, and technical skills. From these three primary strategic leadership skills, there is a list of twenty-one competencies that a strategic leader should posses...

  6. NATO’s Relevance in the Twenty-First Century

    Science.gov (United States)

    2012-03-22

    5a. CONTRACT NUMBER NATO’S RELEVANCE IN THE TWENTY-FIRST CENTURY 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S...belief of community, partnership and cooperation are essential elements of the advancement of self interest.5 In the era of globalization nations still...Christopher Coker, Globalisation and Insecurity in the Twenty-first Century: NATO and the Management of Risk (The International Institute for Strategic

  7. Molluscum contagiosum: serology and electron microscopy findings in twenty one patients

    OpenAIRE

    Fonseca, M. E. F.; R. D. MACHADO; Liberto,M. I. M.; Marcolino,G.

    1987-01-01

    Twenty one cases of molluscum contagiosum virus disease were collected for electron microscopical and serological tests. Molluscum virus was detected in the crust, inside the vacuoles formed in the keratinocytes cells. The patients developed specific antibodies to the virus detected by complement fixation test. Vinte e um casos de molusco contagioso foram escolhidos para serem analisados por testes sorológicos e de microscopia eletrônica. O vírus do molusco foi detectado nas crostas e obse...

  8. Contact toxicity of twenty insecticides applied to Symmerista canicosta

    Science.gov (United States)

    Jacqueline L. Robertson; Robert L. Lyon; Fay L. Shon; Nancy L. Gillette

    1972-01-01

    Twenty insecticides were tested by topical application on mixed groups of 4th- and 5th -stage larvae of Symmerista canicosta Franclemont. Four exceeded DDT in toxicity at LD50 but only resmethrin was significantly mor toxic. Most of the compounds showed unusually high toxicities. Twelve, listed in decreasing order of toxicity...

  9. Tradition and interpretation: Twenty-five attempted approaches - in ...

    African Journals Online (AJOL)

    In a collection of essays in honour of prof E Earle Ellis twenty-five scholars surveyed the present (1987) state of New Testament scholarship and presented their own contributions. The title, Tradition and interpretation in the New Testament, epitomises the paradigm by means of which the authors dealt with issues such as ...

  10. Twenty-One: a baseline for multilingual multimedia retrieval

    NARCIS (Netherlands)

    Unknown, [Unknown; Hiemstra, Djoerd; de Jong, Franciska M.G.; Netter, Klaus

    1998-01-01

    In this paper we will give a short overview of the ideas underpinning the demonstrator developed within the EU-funded project Twenty-One; this system provides for the disclosure of information in a heterogeneous document environment that includes documents of different types and languages. As part

  11. Management of twenty patients with neck trauma in Khartoum ENT ...

    African Journals Online (AJOL)

    Background: Neck trauma is a great surgical challenge, because there are multi organ and systems involved. Objective: To study the clinical presentation, management and outcome of twenty patients presented to Khartoum ENT Hospital with neck trauma. Methods: This is a prospective study conducted in Khartoum ENT ...

  12. University medical education in the twenty first century: Challenges ...

    African Journals Online (AJOL)

    University medical education in the twenty first century: Challenges of social determinants of health and noncommunicable diseases. ... The challenge begins with an analysis of how the Medical Education that is offered at the graduate level prepares graduates in understanding the role of SDH in NCDs. Objectives: To ...

  13. Digital earth applications in the twenty-first century

    NARCIS (Netherlands)

    de By, R.A.; Georgiadou, P.Y.

    2014-01-01

    In these early years of the twenty-first century, we must look at how the truly cross-cutting information technology supports other innovations, and how it will fundamentally change the information positions of government, private sector and the scientific domain as well as the citizen. In those

  14. Twenty Years of The Open University of Tanzania in the ...

    African Journals Online (AJOL)

    Twenty Years of The Open University of Tanzania in the Development of Education in the Country: The Role of OUT in Improving Peoples' Welfare. ... of graduates from 1999 to 2010 has reached 8,830. Students graduating from OUT are engaged in different activities for personal and national socio-economic development.

  15. Genetic variation of twenty autosomal STR loci and evaluate the ...

    African Journals Online (AJOL)

    The aim of this study was of twofold. One was to determine the genetic structure of Iraq population and the second objective of the study was to evaluate the importance of these loci for forensic genetic purposes. FTA® Technology (FTA™ paper DNA extraction) utilized to extract DNA. Twenty (20) STR loci and Amelogenin), ...

  16. Proceedings of the Twenty Second Nordic Seminar on Computational Mechanics

    DEFF Research Database (Denmark)

    This book contains the proceedings of the Twenty Second Nordic Seminar on Computational Mechanics (NSCM22), taking event 22-23 October 2009 at Aalborg University, Denmark. The papers presented at the Optimization Seminar in Honour of Niels Olhoff, held 21 October 2009 at Aalborg University, Denmark......, are included at the end of the proceedings....

  17. Globalisation drivers in the Twenty First Century | Ramakrishina ...

    African Journals Online (AJOL)

    For a global manager it is said that twenty first centenary offers an exciting and challenging atmosphere to work. Does it mean a big change in the way the business has been conducted so far as far or simply means a change in emphasis on certain ways. These currently, are some of the issues which are currently engaging ...

  18. Educational Technologies and Twenty-First Century Leadership for Learning

    Science.gov (United States)

    Schrum, Lynne; Levin, Barbara B.

    2016-01-01

    This article presents information on current aspects in the use of technology to improve student outcomes and engagement, prepare learners for their future and support educators in adopting new pedagogies for teaching and learning. Based on the authors' research of exemplary school leaders and reviewing literature on the use of twenty-first…

  19. Leadership Context for the Twenty-First Century.

    Science.gov (United States)

    Boggs, George R.

    2003-01-01

    Describes an upcoming significant transition in the leadership of Americas community colleges and some potential opportunities and challenges surrounding this leadership turnover. Discusses some rewards of community college leadership and some problems that they face. Identifies some skills that may be necessary for leadership in the twenty-first…

  20. Twenty -year post-treatment assessment of class II division 1 malocclusion treated with non-extraction approach

    Directory of Open Access Journals (Sweden)

    Ashok Karad

    2013-01-01

    This article describes twenty-year post-treatment assessment of a class II division 1 malocclusion case, treated in the late mixed dentition stage, with the non-extraction treatment approach - molar-inserted headgear along with a fixed appliance therapy.

  1. Designing Vaccines for the Twenty-First Century Society

    OpenAIRE

    Finco, Oretta; Rappuoli, Rino

    2014-01-01

    The history of vaccination clearly demonstrates that vaccines have been highly successful in preventing infectious diseases, reducing significantly the incidence of childhood diseases and mortality. However, many infections are still not preventable with the currently available vaccines and they represent a major cause of mortality worldwide. In the twenty-first century, the innovation brought by novel technologies in antigen discovery and formulation together with a deeper knowledge of the h...

  2. Proceedings of the twenty-first LAMPF users group meeting

    Energy Technology Data Exchange (ETDEWEB)

    1988-04-01

    The Twenty-First Annual LAMPF Users Group Meeting was held November 9-10, 1987, at the Clinton P. Anderson Meson Physics Facility. The program included a number of invited talks on various aspects of nuclear and particle physics as well as status reports on LAMPF and discussions of upgrade options. The LAMPF working groups met and discussed plans for the secondary beam lines, experimental programs, and computing facilities.

  3. Proceedings of the twenty-second LAMPF users groupd meeting

    Energy Technology Data Exchange (ETDEWEB)

    Marinuzzi, R.

    1989-04-01

    The Twenty-Second Annual LAMPF Users Group Meeting was held October 17--18, 1988, at the Clinton P. Anderson Meson Physics Facility. The program included a number of invited talks on various aspects of nuclear and particle physics as well as status reports on LAMPF and discussions of upgrade options. The LAMPF working groups met and discussed plans for the secondary beam lines, experimental programs, and computing facilities.

  4. Proceedings of the Twenty-Third Annual Software Engineering Workshop

    Science.gov (United States)

    1999-01-01

    The Twenty-third Annual Software Engineering Workshop (SEW) provided 20 presentations designed to further the goals of the Software Engineering Laboratory (SEL) of the NASA-GSFC. The presentations were selected on their creativity. The sessions which were held on 2-3 of December 1998, centered on the SEL, Experimentation, Inspections, Fault Prediction, Verification and Validation, and Embedded Systems and Safety-Critical Systems.

  5. Open Adoption Placement by Birth Mothers in Their Twenties.

    Science.gov (United States)

    Clutter, Lynn B

    The purpose of this study was to summarize birth mothers' descriptions of unplanned pregnancy experienced in their twenties and how open adoption influenced their lives. Naturalistic inquiry was used with purposive sampling from one agency and telephone interviews of women who experienced unplanned pregnancy in their twenties and relinquishment through open adoption. Recorded, transcribed, and deidentified interviews were analyzed for qualitative themes. Fifteen participants judiciously weighed the open adoption decision. Over half parented other children prior to placement. Most knew they could not have parented this child due to life stressors. Placement was a hard decision, but ongoing contact with birth child and adoptive family was valued. Open adoption processes made them stronger by being happy that their child experienced family life with greater opportunities than birth mothers could offer at the time. Summarized themes used the acronym COMMITTED: C-care deeply about what is best for the child, O-ongoing open adoption: good and hard, M-meeting together regularly, M-moving on in personal growth, accomplishments, and milestones, I-independence from previous stressors or crises, T-transitions, T-therapeutic support, E-emotions, D-depression giving way to deepened strength and personal direction. Open adoption is reinforced as a positive resolution of unintended pregnancy for birth mothers in their twenties.

  6. Early twenty-first-century droughts during the warmest climate

    Directory of Open Access Journals (Sweden)

    Felix Kogan

    2016-01-01

    Full Text Available The first 13 years of the twenty-first century have begun with a series of widespread, long and intensive droughts around the world. Extreme and severe-to-extreme intensity droughts covered 2%–6% and 7%–16% of the world land, respectively, affecting environment, economies and humans. These droughts reduced agricultural production, leading to food shortages, human health deterioration, poverty, regional disturbances, population migration and death. This feature article is a travelogue of the twenty-first-century global and regional droughts during the warmest years of the past 100 years. These droughts were identified and monitored with the National Oceanic and Atmospheric Administration operational space technology, called vegetation health (VH, which has the longest period of observation and provides good data quality. The VH method was used for assessment of vegetation condition or health, including drought early detection and monitoring. The VH method is based on operational satellites data estimating both land surface greenness (NDVI and thermal conditions. The twenty-first-century droughts in the USA, Russia, Australia and Horn of Africa were intensive, long, covered large areas and caused huge losses in agricultural production, which affected food security and led to food riots in some countries. This research also investigates drought dynamics presenting no definite conclusion about drought intensification or/and expansion during the time of the warmest globe.

  7. Rethinking Individual Authorship: Robert Burns, Oral Tradition, and the Twenty-First Century

    Directory of Open Access Journals (Sweden)

    Ruth Knezevich

    2011-10-01

    Full Text Available The songs of late-eighteenth-century Scottish poet Robert Burns provide a rich case study of literature that challenges existing notions of the author as an autonomous entity. Responding to twenty-first-century examples of contested issues of intellectual property and plagiarism in an age of digital media, this project illustrates the ways in which precepts of oral tradition can inform our thinking about cultural production within contexts seemingly permeated by ever-present literacy or text-based thinking in order to provide a new outlook on such situations of artistic borrowing or “plagiarism.”

  8. [Lipemia and bilirubin influences for twenty-four biochemical parameters measurement].

    Science.gov (United States)

    Ali, Damien; Sacchetto, Émilie; Reigner, Arnaud; Le Carrer, Didier; Orsonneau, Jean-Luc; Delaroche, Odile; Bigot-Corbel, Édith

    2015-01-01

    The study of the influence of the lipemia and icterus was performed experimentally for twenty-four biochemistry parameters on the Roche Cobas 6000 CE analyzer. Overloads in Intralipid(®) or ditaurate of bilirubin were performed on several plasma pools. The limit of 10% was chosen to define interference on the measurement. The parameters studied were classified into different categories depending on their measurement is affected or not. Knowledge of these data allows the biologist to adapt its reporting procedures in the case of lactescent and/or icteric samples.

  9. Twenty-first workshop on geothermal reservoir engineering: Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    None

    1996-01-26

    PREFACE The Twenty-First Workshop on Geothermal Reservoir Engineering was held at the Holiday Inn, Palo Alto on January 22-24, 1996. There were one-hundred fifty-five registered participants. Participants came from twenty foreign countries: Argentina, Austria, Canada, Costa Rica, El Salvador, France, Iceland, Indonesia, Italy, Japan, Mexico, The Netherlands, New Zealand, Nicaragua, the Philippines, Romania, Russia, Switzerland, Turkey and the UK. The performance of many geothermal reservoirs outside the United States was described in several of the papers. Professor Roland N. Horne opened the meeting and welcomed visitors. The key note speaker was Marshall Reed, who gave a brief overview of the Department of Energy's current plan. Sixty-six papers were presented in the technical sessions of the workshop. Technical papers were organized into twenty sessions concerning: reservoir assessment, modeling, geology/geochemistry, fracture modeling hot dry rock, geoscience, low enthalpy, injection, well testing, drilling, adsorption and stimulation. Session chairmen were major contributors to the workshop, and we thank: Ben Barker, Bobbie Bishop-Gollan, Tom Box, Jim Combs, John Counsil, Sabodh Garg, Malcolm Grant, Marcel0 Lippmann, Jim Lovekin, John Pritchett, Marshall Reed, Joel Renner, Subir Sanyal, Mike Shook, Alfred Truesdell and Ken Williamson. Jim Lovekin gave the post-dinner speech at the banquet and highlighted the exciting developments in the geothermal field which are taking place worldwide. The Workshop was organized by the Stanford Geothermal Program faculty, staff, and graduate students. We wish to thank our students who operated the audiovisual equipment. Shaun D. Fitzgerald Program Manager.

  10. Twenty Questions for Noël Arnaud

    Directory of Open Access Journals (Sweden)

    Warren F. Motte Jr.

    1986-01-01

    Full Text Available Noël Arnaud, the president of the Ouvroir de Litterature Potentielle (Oulipo, discusses that institution's history, its literary aesthetic, and its goals. He offers art assessment of twenty-five years of Oulipian activity, in the course of which he touches upon notions which are crucial to the Oulipo's praxis: the fundamental analogy of mathematics and literature, the role of formal constraint in the literary text, and the mutual complementarity of scholarship in literary history and the practice of innovative literary experimentalism.

  11. In vitro Toxicity Testing in the Twenty-First Century.

    Science.gov (United States)

    Roggen, Erwin L

    2011-01-01

    The National Research Council (NRC) article "Toxicity Testing in the 21st Century: A vision and A Strategy" (National Research Council, 2007) was written to bring attention to the application of scientific advances for use in toxicity tests so that chemicals can be tested in a more time and cost efficient manner while providing a more relevant and mechanistic insight into the toxic potential of a compound. Development of tools for in vitro toxicity testing constitutes an important activity of this vision and contributes to the provision of test systems as well as data that are essential for the development of computer modeling tools for, e.g., system biology, physiologically based modeling. This article intends to highlight some of the issues that have to be addressed in order to make in vitro toxicity testing a reality in the twenty-first century.

  12. The Turn to Precarity in Twenty-First Century Fiction

    Directory of Open Access Journals (Sweden)

    Morrison Jago

    2014-01-01

    Full Text Available Recent years have seen several attempts by writers and critics to understand the changed sensibility in post-9/11 fiction through a variety of new -isms. This essay explores this cultural shift in a different way, finding a ‘turn to precarity’ in twenty-first century fiction characterised by a renewal of interest in the flow and foreclosure of affect, the resurgence of questions about vulnerability and our relationships to the other, and a heightened awareness of the social dynamics of seeing. The essay draws these tendencies together via the work of Judith Butler in Frames of War, in an analysis of Trezza Azzopardi’s quasi-biographical study of precarious life, Remember Me.

  13. Criminological psychology in the twenty-first century.

    Science.gov (United States)

    Farrington, David P

    2004-01-01

    This article aims to review key issues that criminological psychologists should address in the twenty-first century, especially in relation to why people become offenders, why people commit offences, and the link between explanation and the prevention and reduction of offending. It is important to explain between-individual differences in the development of criminal potential and within-individual differences in the commission of crimes. More research is needed on protective factors, on investigating which risk factors are causes, and on causal mechanisms linking risk factors and offending. Questions about situational influences on offending should be included in longitudinal studies of the development of offenders. Comprehensive theories of offending need to be developed and tested. More longitudinal and experimental studies need to be carried out by criminological psychologists.

  14. The Dialectics of Discrimination in the Twenty-First Century

    Directory of Open Access Journals (Sweden)

    John Stone

    2007-12-01

    Full Text Available This article explores some of the latest developments in the scholarship on race relations and nationalism that seek to address the impact of globalization and the changed geo-political relations of the first decade of the twenty-first century. New patterns of identification, some of which challenge existing group boundaries and others that reinforce them, can be seen to flow from the effects of global market changes and the political counter-movements against them. The impact of the “war on terrorism”, the limits of the utility of hard power, and the need for new mechanisms of inter-racial and inter-ethnic conflict resolution are evaluated to emphasize the complexity of these group relations in the new world disorder.

  15. TWENTY-ONE-YEAR-OLD MALE WITH CONGENITAL ANOMALIES,

    African Journals Online (AJOL)

    This report presents the case of a 21-year-old secondary school leaver as a likely case of Townes-Brocks syndrome. He was born with congenital abnormalities consisting of fixed flexion deformities of hands, wrist and elbows, urethral meatal stenosis, scoliosis and aortic stenosis. He was diagnosed with obstructive.

  16. Twenty-one-year-old male with congenital anomalies, obstructive ...

    African Journals Online (AJOL)

    Townes – Brocks syndrome is an autosomal dominant multiple malformations syndrome comprising of ear anomalies/hearing loss, limb defects, anal, genitourinary, eye, spine anomalies, heart defects and sometimes mental retardation. This report presents the case of a 21-year-old secondary school leaver as a likely case ...

  17. Twenty-Four Genes are Upregulated in Patients with Hypospadias

    Science.gov (United States)

    Karabulut, R; Turkyilmaz, Z; Sonmez, K; Kumas, G; Ergun, SG; Ergun, MA; Basaklar, AC

    2013-01-01

    Hypospadias is a congenital hypoplasia of the penis, with displacement of the urethral opening along the ventral surface, and has been reported to be one of the most common congenital anomalies, occurring in approximately 1:250 to 1:300 live births. As hypospadias is reported to be an easily diagnosed malformation at the crossroads of genetics and environment, it is important to study the genetic component in order to elucidate its etiology. In this study, the gene expression profiles both in human hypospadias tissues and normal penile tissues were studied by Human Gene Expression Array. Twenty-four genes were found to be upregulated. Among these, ATF3 and CYR61 have been reported previously. Other genes that have not been previously reported were also found to be upregulated: BTG2, CD69, CD9, DUSP1, EGR1, EIF4A1, FOS, FOSB, HBEGF, HNRNPUL1, IER2, JUN, JUNB, KLF2, NR4A1, NR4A2, PTGS2, RGS1, RTN4, SLC25A25, SOCS3 and ZFP36 (p <0.05). Further studies including genome-wide association studies (GWAS) with expression studies in a large patient group will help us for identifiying the candidate gene(s) in the etiology of hypospadias. PMID:24778562

  18. Twenty-second Fungal Genetics Conference - Asilomar, 2003

    Energy Technology Data Exchange (ETDEWEB)

    Jonathan D. Walton

    2003-06-30

    The purpose of the Twenty Second Fungal Genetics Conference is to bring together scientists and students who are interested in genetic approaches to studying the biology of filamentous fungi. It is intended to stimulate thinking and discussion in an atmosphere that supports interactions between scientists at different levels and in different disciplines. Topics range from the basic to the applied. Filamentous fungi impact human affairs in many ways. In the environment they are the most important agents of decay and nutrient turnover. They are used extensively in the food industry for the production of food enzymes such as pectinase and food additives such as citric acid. They are used in the production of fermented foods such as alcoholic drinks, bread, cheese, and soy sauce. More than a dozen species of mushrooms are used as foods directly. Many of our most important antibiotics, such as penicillin, cyclosporin, and lovastatin, come from fungi. Fungi also have many negative impacts on human health and economics. Fungi are serious pathogens in immuno-compromised patients. Fungi are the single largest group of plant pathogens and thus a serious limit on crop productivity throughout the world. Many fungi are allergenic, and mold contamination of residences and commercial buildings is now recognized as a serious public health threat. As decomposers, fungi cause extensive damage to just about all natural and synthetic materials.

  19. Twenty years of minimally invasive surgery in the Czech Republic

    Directory of Open Access Journals (Sweden)

    Miloslav Duda

    2011-03-01

    increased over the last twenty years, and the range of types of surgical therapies has enlarged.

  20. Children's environmental health in the twenty-first century.

    Science.gov (United States)

    Pronczuk, Jenny; Surdu, Simona

    2008-10-01

    In the twenty-first century, the global burden of disease trends are the result of complex interaction among rapid industrialization and urbanization, unsustainable use of natural resources, and population growth. In addition, global environmental changes due to climate change, ozone depletion, desertification/deforestation, loss of biodiversity, and increased used of some biotechnologies are having an important impact on human health. Many other factors also play an important role in the population's health response to global environmental threats, including poverty, malnutrition, poor sanitation, and infectious diseases. Worldwide, the burden of environmental disease is much higher for children than adults, especially in young children under 5 years of age. Quantification of the burden of diseases attributable to environment shows that environmental risk factors can contribute to more than one-third of the disease burden in children, a fraction of disease that could be prevented. Children are often exposed to multiple environmental threats combined with other behavioral, social, and economic risk factors. Many of the environmental health risk factors are shared among children's home, school, and community. Therefore, an integrated approach should be considered in order to create healthy environments for children. The promotion of safe environments for children has to involve decision makers, nongovernmental organizations (NGOs), families, and various sectors including health, education, housing, environment, agriculture, industry, transport, and energy. Multiple initiatives have been proposed from collection, evaluation, and dissemination of information on children's health and the potential environmental threats to research, monitoring, risk assessment, and policies to improve the environmental conditions and ultimately children's growth and development.

  1. Prader-Willi syndrome in neonates: twenty cases and review of the literature in Southern China.

    Science.gov (United States)

    Wang, Ping; Zhou, Wei; Yuan, Weiming; Huang, Longguang; Zhao, Ning; Chen, Xiaowen

    2016-08-09

    Prader-Willi syndrome is a rare genetic abnormality that can be challenging to diagnose early, but for which early interventions improve prognosis. To improve understanding of Prader-Willi syndrome in neonates in Asia, we retrospectively analyzed the clinical records of 20 affected newborns diagnosed in the Department of Neonatology, Guangzhou Women and Children's Medical Center, Guangzhou, China from January 2007 to December 2014 and performed a review of the relevant literature. Fourteen boys and six girls presented with hypotonia, poor responsiveness, feeding difficulty, and infrequent, weak crying. Different from western patients, the 20 Asian patients exhibited at least five of the following typical features: prominent forehead, narrow face, almond-shaped eyes, small mouth, downturned mouth, thin upper lip, and micromandible. All 14 boys had a small scrotum, including nine with cryptorchidism. Diagnoses were made with microarray comparative genomic hybridization. All 20 infants required feeding tubes. Fifteen received swallowing training immediately after admission; the period of continuous tube feeding for these patients ranged from 8 to 22 days (mean, 14 ± 5.3 days). For the five patients who did not receive swallowing training, the period of continuous tube feeding ranged from 15 to 35 days (mean, 18 ± 4.3 days). Comprehensive care measures included: giving parents detailed health education and basic information about this disease, teaching skills to promote feeding and prevent suffocation, increasing children's passive activity, providing nutrition management for normal development, and preventing excessive or inadequate nutrient intake. Neonates with Prader-Willi syndrome in Asia have hypotonia, poor responsiveness, feeding difficulty, infrequent and weak crying, genital hypoplasia, and characteristic facial features. Recognition of the syndrome in neonates with confirmation by genetic testing is essential, because early diagnosis allows early intervention. Treatment measures including swallowing training can improve prognosis, prevent growth retardation and obesity, and elevate quality of life in individuals with Prader-Willi syndrome.

  2. Twenty Years of Cognitive Dissonance: Case Study of the Evolution of a Theory

    Science.gov (United States)

    Greenwald, Anthony G.; Ronis, David L.

    1978-01-01

    Recent revisions of cognitive dissonance theory no longer encompass some of the important examples, data, and hypotheses that were part of Festinger's (1957) original statement. These changes are so substantial as to prompt the observation that the evolved theory might be identified as a different theory. (Editor/RK)

  3. DEVELOPING EFFECTIVE ARMED FORCES IN THE TWENTY FIRST CENTURY CASE STUDIES OF NEW DEMOCRACIES

    Directory of Open Access Journals (Sweden)

    Florina Cristiana (Cris MATEI

    2011-01-01

    Full Text Available The purpose of this article is to contribute to a better understanding of thecontemporary value for democracy of the relationship between elected leadersand the armed forces. Hence, it focuses on the military effectiveness dimension ofthe CMR. It discusses why it is important and what newer democracies can do tosuccessfully develop effective armed forces. The article provides “lessons learned/best practices” of achieving effectiveness from three developing democracies - Chile,Hungary, and, Mongolia.

  4. morbid obesity in a twenty one year old beggar: a case report

    African Journals Online (AJOL)

    21% for both in 20004. In the United States, the figure are not different. It is estimated that 34% of adults aged 20 to 74 yrs are overweight and an additional. 24% are obeses. These percentages are higher in. African Americans. Native Americans and Mexican. Arnericanss. There are no established figures from our local ...

  5. Measuring Organizational Cultures: A Qualitative and Quantitative Study across Twenty Cases.

    Science.gov (United States)

    Hofstede, Geert; And Others

    1990-01-01

    Presents the results of a study on organizational cultures in 20 units from 10 different organizations in Denmark and the Netherlands. The major project outcome is a 6-dimensional model of organizational cultures, defined as perceived practices. Labelling positions on the dimensions scales as more or less desirable is a matter of strategic choice.…

  6. The natural history of clinical operational tolerance after kidney transplantation through twenty-seven cases.

    Science.gov (United States)

    Brouard, S; Pallier, A; Renaudin, K; Foucher, Y; Danger, R; Devys, A; Cesbron, A; Guillot-Guegen, C; Ashton-Chess, J; Le Roux, S; Harb, J; Roussey, G; Subra, J-F; Villemain, F; Legendre, C; Bemelman, F J; Orlando, G; Garnier, A; Jambon, H; Le Monies De Sagazan, H; Braun, L; Noël, C; Pillebout, E; Moal, M-C; Cantarell, C; Hoitsma, A; Ranbant, M; Testa, A; Soulillou, J-P; Giral, M

    2012-12-01

    We report here on a European cohort of 27 kidney transplant recipients displaying operational tolerance, compared to two cohorts of matched kidney transplant recipients under immunosuppression and patients who stopped immunosuppressive drugs and presented with rejection. We report that a lower proportion of operationally tolerant patients received induction therapy (52% without induction therapy vs. 78.3%[p = 0.0455] and 96.7%[p = 0.0001], respectively), a difference likely due to the higher proportion (18.5%) of HLA matched recipients in the tolerant cohort. These patients were also significantly older at the time of transplantation (p = 0.0211) and immunosuppression withdrawal (p = 0.0002) than recipients who rejected their graft after weaning. Finally, these patients were at lower risk of infectious disease. Among the 27 patients defined as operationally tolerant at the time of inclusion, 19 still display stable graft function (mean 9 ± 4 years after transplantation) whereas 30% presented slow deterioration of graft function. Six of these patients tested positive for pre-graft anti-HLA antibodies. Biopsy histology studies revealed an active immunologically driven mechanism for half of them, associated with DSA in the absence of C4d. This study suggests that operational tolerance can persist as a robust phenomenon, although eventual graft loss does occur in some patients, particularly in the setting of donor-specific alloantibody. © Copyright 2012 The American Society of Transplantation and the American Society of Transplant Surgeons.

  7. The Natural History of Clinical Operational Tolerance After Kidney Transplantation Through Twenty-Seven Cases

    NARCIS (Netherlands)

    Brouard, S.; Pallier, A.; Renaudin, K.; Foucher, Y.; Danger, R.; Devys, A.; Cesbron, A.; Guillot-Guegen, C.; Ashton-Chess, J.; Roux, S. le; Harb, J.; Roussey, G.; Subra, J.F.; Villemain, F.; Legendre, C.; Bemelman, F.J.; Orlando, G.; Garnier, A.; Jambon, H.; Monies De Sagazan, H. le; Braun, L.; Noel, C.; Pillebout, E.; Moal, M.C.; Cantarell, C.; Hoitsma, A.J.; Ranbant, M.; Testa, A.; Soulillou, J.P.; Giral, M.

    2012-01-01

    We report here on a European cohort of 27 kidney transplant recipients displaying operational tolerance, compared to two cohorts of matched kidney transplant recipients under immunosuppression and patients who stopped immunosuppressive drugs and presented with rejection. We report that a lower

  8. The new South Africa at twenty: Critical perspectives

    African Journals Online (AJOL)

    the Chapter 5 case study concerning 'Neoliberal restructuring and the fate of South Africa's labour unions' by Hlatswayo, there is considerable insight provided into, inter alia, current policy directions through careful consideration of a number of key issues. Chief amongst these are the country's industrial policy post-1994, ...

  9. Twenty-Five Year Site Plan FY2013 - FY2037

    Energy Technology Data Exchange (ETDEWEB)

    Jones, William H. [Los Alamos National Laboratory

    2012-07-12

    Los Alamos National Laboratory (the Laboratory) is the nation's premier national security science laboratory. Its mission is to develop and apply science and technology to ensure the safety, security, and reliability of the United States (U.S.) nuclear stockpile; reduce the threat of weapons of mass destruction, proliferation, and terrorism; and solve national problems in defense, energy, and the environment. The fiscal year (FY) 2013-2037 Twenty-Five Year Site Plan (TYSP) is a vital component for planning to meet the National Nuclear Security Administration (NNSA) commitment to ensure the U.S. has a safe, secure, and reliable nuclear deterrent. The Laboratory also uses the TYSP as an integrated planning tool to guide development of an efficient and responsive infrastructure that effectively supports the Laboratory's missions and workforce. Emphasizing the Laboratory's core capabilities, this TYSP reflects the Laboratory's role as a prominent contributor to NNSA missions through its programs and campaigns. The Laboratory is aligned with Nuclear Security Enterprise (NSE) modernization activities outlined in the NNSA Strategic Plan (May 2011) which include: (1) ensuring laboratory plutonium space effectively supports pit manufacturing and enterprise-wide special nuclear materials consolidation; (2) constructing the Chemistry and Metallurgy Research Replacement Nuclear Facility (CMRR-NF); (3) establishing shared user facilities to more cost effectively manage high-value, experimental, computational and production capabilities; and (4) modernizing enduring facilities while reducing the excess facility footprint. Th is TYSP is viewed by the Laboratory as a vital planning tool to develop an effi cient and responsive infrastructure. Long range facility and infrastructure development planning are critical to assure sustainment and modernization. Out-year re-investment is essential for sustaining existing facilities, and will be re-evaluated on an annual

  10. Understanding Contamination; Twenty Years of Simulating Radiological Contamination

    Energy Technology Data Exchange (ETDEWEB)

    Emily Snyder; John Drake; Ryan James

    2012-02-01

    A wide variety of simulated contamination methods have been developed by researchers to reproducibly test radiological decontamination methods. Some twenty years ago a method of non-radioactive contamination simulation was proposed at the Idaho National Laboratory (INL) that mimicked the character of radioactive cesium and zirconium contamination on stainless steel. It involved baking the contamination into the surface of the stainless steel in order to 'fix' it into a tenacious, tightly bound oxide layer. This type of contamination was particularly applicable to nuclear processing facilities (and nuclear reactors) where oxide growth and exchange of radioactive materials within the oxide layer became the predominant model for material/contaminant interaction. Additional simulation methods and their empirically derived basis (from a nuclear fuel reprocessing facility) are discussed. In the last ten years the INL, working with the Defense Advanced Research Projects Agency (DARPA) and the National Homeland Security Research Center (NHSRC), has continued to develop contamination simulation methodologies. The most notable of these newer methodologies was developed to compare the efficacy of different decontamination technologies against radiological dispersal device (RDD, 'dirty bomb') type of contamination. There are many different scenarios for how RDD contamination may be spread, but the most commonly used one at the INL involves the dispersal of an aqueous solution containing radioactive Cs-137. This method was chosen during the DARPA projects and has continued through the NHSRC series of decontamination trials and also gives a tenacious 'fixed' contamination. Much has been learned about the interaction of cesium contamination with building materials, particularly concrete, throughout these tests. The effects of porosity, cation-exchange capacity of the material and the amount of dirt and debris on the surface are very important factors

  11. "Créolization" and the New Cosmopolitanism: Examining Twenty-First-Century Student Identities and Literacy Practices for Transcultural Understanding

    Science.gov (United States)

    Lemrow, Erin Moira

    2017-01-01

    This paper considers the rapid demographic shifts in contemporary American society as they manifest themselves in today's classrooms in the United States. An effort to articulate these twenty-first-century student identities is highlighted in data from an ethnographic case study examining the literacy practices of one student of Filipino and…

  12. Twenty-First Century Diseases: Commonly Rare and Rarely Common?

    Science.gov (United States)

    Daunert, Sylvia; Sittampalam, Gurusingham Sitta; Goldschmidt-Clermont, Pascal J

    2017-09-20

    Alzheimer's drugs are failing at a rate of 99.6%, and success rate for drugs designed to help patients with this form of dementia is 47 times less than for drugs designed to help patients with cancers ( www.scientificamerican.com/article/why-alzheimer-s-drugs-keep-failing/2014 ). How can it be so difficult to produce a valuable drug for Alzheimer's disease? Each human has a unique genetic and epigenetic makeup, thus endowing individuals with a highly unique complement of genes, polymorphisms, mutations, RNAs, proteins, lipids, and complex sugars, resulting in distinct genome, proteome, metabolome, and also microbiome identity. This editorial is taking into account the uniqueness of each individual and surrounding environment, and stresses the point that a more accurate definition of a "common" disorder could be simply the amalgamation of a myriad of "rare" diseases. These rare diseases are being grouped together because they share a rather constant complement of common features and, indeed, generally respond to empirically developed treatments, leading to a positive outcome consistently. We make the case that it is highly unlikely that such treatments, despite their statistical success measured with large cohorts using standardized clinical research, will be effective on all patients until we increase the depth and fidelity of our understanding of the individual "rare" diseases that are grouped together in the "buckets" of common illnesses. Antioxid. Redox Signal. 27, 511-516.

  13. The restructuring of the Argentina Navy between the end of the twentieth century and early twenty-first.

    Directory of Open Access Journals (Sweden)

    Germán Soprano

    2017-07-01

    Full Text Available The definition of a policy of national defense and internal security in democracy, created conditions to advance in the process of restructuring of the Argentina Navy, introducing changes in its organization and functions. In this article we will focus this process analyzing, on the one hand, the relationship between the definitions of defense policy and the configuration of naval military instrument between the end of the twentieth century and early twenty-first century; and, on the other hand, understanding their development in the case of two components of the force: the marine corps and the division of maritime patrol.

  14. 77 FR 25781 - Twenty-First Meeting: RTCA Special Committee 203, Unmanned Aircraft Systems

    Science.gov (United States)

    2012-05-01

    ...: Meeting Notice of RTCA Special Committee 203, Unmanned Aircraft Systems. SUMMARY: The FAA is issuing this notice to advise the public of the twenty-first meeting of RTCA Special Committee 203, Unmanned Aircraft... Federal Aviation Administration Twenty-First Meeting: RTCA Special Committee 203, Unmanned Aircraft...

  15. 77 FR 50207 - Twenty-Second Meeting: RTCA Special Committee 203, Unmanned Aircraft Systems

    Science.gov (United States)

    2012-08-20

    ...: Meeting notice of RTCA Special Committee 203, Unmanned Aircraft Systems. SUMMARY: The FAA is issuing this notice to advise the public of the twenty-second meeting of RTCA Special Committee 203, Unmanned Aircraft... Federal Aviation Administration Twenty-Second Meeting: RTCA Special Committee 203, Unmanned Aircraft...

  16. 78 FR 6400 - Twenty Third Meeting: RTCA Special Committee 203, Unmanned Aircraft Systems

    Science.gov (United States)

    2013-01-30

    ...: Meeting Notice of RTCA Special Committee 203, Unmanned Aircraft Systems. SUMMARY: The FAA is issuing this notice to advise the public of the twenty third meeting of RTCA Special Committee 203, Unmanned Aircraft... Federal Aviation Administration Twenty Third Meeting: RTCA Special Committee 203, Unmanned Aircraft...

  17. Digital Systems Supporting Cognition and Exploratory Learning in Twenty-First Century: Guest Editorial

    Science.gov (United States)

    Spector, J. Michael; Ifenthaler, Dirk; Sampson, Demetrios G.

    2016-01-01

    Digital systems and digital technologies are globally investigated for their potential to transform learning, teaching and assessment towards offering unique learning experiences to the twenty-first century learners. This Special Issue on "Digital systems supporting cognition and exploratory learning in twenty-first century" aims to…

  18. 38 CFR 8.31 - Total disability for twenty years or more.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Total disability for twenty years or more. 8.31 Section 8.31 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS NATIONAL SERVICE LIFE INSURANCE Appeals § 8.31 Total disability for twenty years or more. Where the Disability Insurance Claims activity has...

  19. Preparing Students for a Twenty-First Century Global Workplace in an Era of Accountability

    Science.gov (United States)

    Cognetta, Sebastian

    2010-01-01

    The purpose of the study is to thoroughly examine a school district's plan for developing, implementing, and monitoring a strategic plan for adequately preparing students with twenty-first century skills or the marketable skills students will need in order to contribute to the dynamic twenty-first century workplace while meeting federal and state…

  20. A Critical Feminist and Race Critique of Thomas Piketty's "Capital in the Twenty-First Century"

    Science.gov (United States)

    Moeller, Kathryn

    2016-01-01

    Thomas Piketty's "Capital in the Twenty-first Century" documents the foreboding nature of rising wealth inequality in the twenty-first century. In an effort to promote a more just and democratic global society and rein in the unfettered accumulation of wealth by the few, Piketty calls for a global progressive annual tax on corporate…

  1. Slowmation: A Twenty-First Century Educational Tool for Science and Mathematics Pre-Service Teachers

    Science.gov (United States)

    Paige, Kathryn; Bentley, Brendan; Dobson, Stephen

    2016-01-01

    Slowmation is a twenty-first century digital literacy educational tool. This teaching and learning tool has been incorporated as an assessment strategy in the curriculum area of science and mathematics with pre-service teachers (PSTs). This paper explores two themes: developing twenty-first century digital literacy skills and modelling best…

  2. 76 FR 68117 - Video Description: Implementation of the Twenty-First Century Communications and Video...

    Science.gov (United States)

    2011-11-03

    ... No. 11-43; FCC 11-126] Video Description: Implementation of the Twenty-First Century Communications and Video Accessibility Act of 2010 AGENCY: Federal Communications Commission. ACTION: Final rule... September 8, 2011, a document concerning implementation of the Video Description elements of the Twenty...

  3. Project Kaleidoscope 2.0: Leadership for Twenty-First Century STEM Education

    Science.gov (United States)

    Elrod, Susan

    2010-01-01

    It has been over twenty years since the publication of reports calling for increased efforts to reform undergraduate STEM (science, technology, engineering, and mathematics) education. There are more STEM classrooms today that utilize "pedagogies of engagement" than there were twenty years ago; however, these kinds of learning environments are…

  4. Twenty Years of Adult Congenital Heart Surgery: A Single-Center African Experience.

    Science.gov (United States)

    Long, Michael A; Smit, Francis E; Brown, Stephen C

    2016-09-01

    Lack of data exists on the surgical management of adult congenital heart disease on the African continent. This study was undertaken to describe the clinical profile and surgical outcome of adult patients with congenital heart disease undergoing surgery in a single-center African study population. A retrospective medical chart review of consecutive adult patients (≥18 years) undergoing congenital heart surgery between October 1995 and December 2015 at our institution was undertaken. We described cardiac diagnosis, diagnostic complexity, risk profile, and surgical morbidity and mortality. Data were collected of 233 surgical procedures performed in 219 patients (45.6% males). The most common diagnostic category was septal defects (41.2%), followed by right heart lesions (17.2%), left heart lesions (12.4%), thoracic arteries (9.0%), and conduit failure (6.9%). Twenty-four percent of patients presented in functional class III or IV, and 46% of patients met the criteria for the simple Bethesda diagnostic class. Preoperative risk factors were identified in 19.8% of patients. Corrective surgery was performed in 71.7% of cases, reoperative surgery in 27.6%, and palliative surgery in 0.8%. Right ventricle to pulmonary artery conduit placement comprised 53.1% of reoperations. The overall hospital mortality was 1.7%. Postoperative complications occurred in 26.3% of cases. This study presents a detailed description of this emerging population in a developing world context. Our outcomes data suggest that adult congenital heart disease surgery is feasible in a Southern African tertiary referral center with low operative mortality and acceptable morbidity. © The Author(s) 2016.

  5. Chapter Twenty

    African Journals Online (AJOL)

    User

    Oil has constituted a physical problem to Delta State and Nigeria as a whole. It is a serious impediment to survival among the indigenes of Niger Delta area. It has constituted nuisance which inhibits economic growth and endangers lives and property. It annuls indigenous participation in oil excavations to assure survival ...

  6. A Farewell to Innocence? African Youth and Violence in the Twenty-First Century

    National Research Council Canada - National Science Library

    Charles Ugochukwu Ukeje; Akin Iwilade

    2012-01-01

      This is a broad examination of the issue of youth violence in twenty-first-century Africa, looking at the context within which a youth culture of violence has evolved and attempting to understand...

  7. Emerging Tick-Borne Viruses in the Twenty-First Century

    National Research Council Canada - National Science Library

    Karen L. Mansfield; Lv Jizhou; L. Paul Phipps; Nicholas Johnson

    2017-01-01

    .... For some viruses, even the principal tick-vector is not known. It is likely that tick-borne viruses will continue to emerge and challenge public and veterinary health long into the twenty-first...

  8. Yeast culture collections in the twenty-first century: new opportunities and challenges

    NARCIS (Netherlands)

    Boundy-Mills, Kyria L.; Glantschnig, Ewald; Roberts, Ian N.; Yurkov, Andrey; Casaregola, Serge; Daniel, Heide-Marie; Groenewald, Marizeth; Turchetti, Benedetta

    The twenty-first century has brought new opportunities and challenges to yeast culture collections, whether they are long-standing or recently established. Basic functions such as archiving, characterizing and distributing yeasts continue, but with expanded responsibilities and emerging

  9. Twenty-fourth Semiannual Report of the Commission to the Congress, July 1958

    Energy Technology Data Exchange (ETDEWEB)

    Strauss, Lewis L.; McCone, John A.

    1958-07-31

    The document represents the twenty-fourth semiannual Atomic Energy Commission (AEC) report to Congress. The report sums up the major activities and developments in the national atomic energy program covering the period January - June 1958.

  10. Twenty-second Semiannual Report of the Commission to the Congress, July 1957

    Energy Technology Data Exchange (ETDEWEB)

    Strauss, Lewis L.

    1957-07-31

    The document represents the twenty-second semiannual Atomic Energy Commission (AEC) report to Congress. The report sums up the major activities and developments in the national atomic energy program covering the period January - June 1957.

  11. Models of «business twenty» governance: possibilities of optimization

    Directory of Open Access Journals (Sweden)

    Alisa A. Prokhorova

    2017-01-01

    Full Text Available Abstract: The article investigates the activities and structure of the «Group of Twenty» (G20 main outreach group - «Business Twenty» (B20. «Group of Twenty» is one of the leading international economic summitry institutions, which has enough capacity to infl uence on the development and implementation at the level of global community policies. B20 aims at facilitating the development of sustainable economic growth which, in turn, would contribute to job creation as well as representation and protection of the interests of the national business communities in dialogue with the G20. One of the main B20 objectives is to make an impact on the G20 agenda and fi nal commitments, with an emphasis on the consolidated interests of the global business community as the main participants of the outreach group are business associations, CEOs of global corporations, consulting organizations.The approach to the B20 organization differs, for the seven-year history of the G20-B20 dialogue the permanent format has not been worked out and there is no unifi ed, rolling from the Chairman to Chairman mechanism of representation of the business interests within the «Group of Twenty».Analysis of different «Business Twenty» organizational models allowed to sort out the main elements of the institution entrusted with executive functions: Chairman of «Business Twenty», «Troika», Chairs and Co-Chairs of Task Forces. The investigation suggests possible ways of their optimization in accordance with the criterion of effi ciency which is defi ned by the engagement of business community in the process of recommendations development, ensure of the maximum implementation of the business-community recommendations in the «Group of Twenty» fi nal documents, possibility of a subsequent implementation of the assumed by «Group of Twenty» obligations.

  12. Twenty-three-hour stay loop ileostomy closures: a pilot study.

    Science.gov (United States)

    Peacock, O; Bhalla, A; Simpson, J A; Gold, S; Hurst, N G; Speake, W J; Tierney, G M; Lund, J N

    2013-02-01

    In UK in 2010-2011, 4,463 ileostomy closures were performed (35,442 bed days) with a median inpatient stay of 5 days (Hospital Episode Statistics data). This seems anomalous when there are reports of 23-h stay colectomies. We present our early experience of 23-h discharge for loop ileostomy closures. A specific patient journey/pathway for 23-h discharge following loop ileostomy closure was implemented at a single UK institution between August 2011 and April 2012. Follow-up was by telephone contact 24-48 h postdischarge and by routine outpatient appointment, and patients were also provided with a 24-h contact point in case of emergency. Twenty-three patients were included (18 male patients; median age, 63 years; range, 28-78 years). Fifteen were discharged within 23 h. The remaining 8 patients were all discharged within 48 h of surgery. Four patients were readmitted with superficial wound infection (1), slight wound discharge (1), Clostridium difficile diarrhoea (1) and an anastomotic leak 8 days after surgery (1). Median length of follow-up was 3 months (range, 1-10 months). A specific 23-h discharge protocol for loop ileostomy closures is feasible and safe. Improved primary care and out-of-hours hospital support would have prevented both minor wound complications requiring readmission. The anastomotic leak presented at postoperative day 8 and would have occurred in the community even if a standard protocol was used. Additional patient information and support via stoma care have been introduced to build on our experience, and 23-h stay has been introduced as standard care.

  13. Pediatric and congenital heart transplant: twenty-year experience in a tertiary Brazilian Hospital

    Directory of Open Access Journals (Sweden)

    Leonardo Augusto Miana

    2014-09-01

    Full Text Available Introduction: Cardiac transplantation remains the gold standard for end-stage cardiomyopathies and congenital heart defects in pediatric patients. Objective: This study aims to report on 20 years of experience since the first case and evaluate our results. Methods: We conducted a retrospective analysis of the database and outpatient follow-up. Between October 1992 and April 2012, 109 patients underwent 114 transplants. 51.8% of them being female. The age of patients ranged from 12 days to 21 years with a mean of 8.8±5.7 years and a median of 5.2 years. The underlying diagnosis was dilated cardiomyopathy in 61.5%, congenital heart disease in 26.6% and restrictive cardiomyopathy in 11.9%. All patients above 17 years old had congenital heart disease. Results: Survival rate at 30 days, 1, 5, 10, 15, and 20 years were 90.4%, 81.3%, 70.9%, 60.5%, 44.4% and 26.7%, respectively. Mean cold ischemic time was 187.9 minutes and it did not correlate with mortality (P>0.05. Infectious complications and rejection episodes were the most common complications (P<0.0001, occurring, respectively, in 66% and 57.4% of the survivors after 10 years. There was no incidence of graft vascular disease and lymphoproliferative disease at year one, but they affected, respectively, 7.4% and 11% of patients within 10 years. Conclusion: Twenty-year pediatric heart transplant results at our institution were quite satisfactory and complication rates were acceptable.

  14. Twenty-five years of transient counting experience in French PWR units

    Energy Technology Data Exchange (ETDEWEB)

    Barthelet, B. [Electricite de France (EDF DPN), 93 - Saint-Denis (France); Savoldelli, D.; Fritz, R. [Electricite de France (EDF DPN), 93 - Noisy le Grand (France)

    2001-07-01

    For nearly twenty five years, EDF has been checking that the actual operating transients are neither more severe nor more numerous than the design basis transients. This activity of transient cycle counting and bookkeeping has enabled EDF to own a database of more than 800 reactor.years for the PWR units. The current method of transient cycle counting is presented. In the paper, we will point out the main results of transient cycle counting and lessons learned. In general, the frequencies of transients are lower than the design frequencies. In few cases, they are higher, such as the transient frequencies of the RCS lines connected to auxiliary systems often due to operating procedures or particular periodic testing. Few periodic tests were not taken into account in the design basis transient file ; they have been detected thanks to the transient cycle counting. In the last 1980's, we achieved the first updating of the design basis transient file for the PWR 900 MWe series. In the early 1990's, we updated the design basis transient file of the PWR 1300 MWe series. In fact, since design and start-up, the operating conditions have been modified (fuel cycle with stretch-out, modification of the hot leg and cold leg temperatures for the PWR 1300 MWe,...). This was the cause of many unclassified transients. In the new design basis transient file, we have created new transients and increased the frequencies of some of them. This has enabled to consider the updated design basis transient file more representative of actual operating transients. For some years, we have increasingly associated the operators with the transient cycle counting concern. We noticed progress (decreased frequencies of most transients). (authors)

  15. Twenty Questions game performance on medical school entrance predicts clinical performance.

    Science.gov (United States)

    Williams, Reed G; Klamen, Debra L

    2015-09-01

    This study is based on the premise that the game of 'Twenty Questions' (TQ) tests the knowledge people acquire through their lives and how well they organise and store it so that they can effectively retrieve, combine and use it to address new life challenges. Therefore, performance on TQ may predict how effectively medical school applicants will organise and store knowledge they acquire during medical training to support their work as doctors. This study was designed to determine whether TQ game performance on medical school entrance predicts performance on a clinical performance examination near graduation. This prospective, longitudinal, observational study involved each medical student in one class playing a game of TQ on a non-medical topic during the first week of medical school. Near graduation, these students completed a 14-case clinical performance examination. Performance on the TQ task was compared with performance on the clinical performance examination. The 24 students who exhibited a logical approach to the TQ task performed better on all senior clinical performance examination measures than did the 26 students who exhibited a random approach. Approach to the task was a better predictor of senior examination diagnosis justification performance than was the Medical College Admission Test (MCAT) Biological Science Test score and accounts for a substantial amount of score variation not attributable to a co-relationship with MCAT Biological Science Test performance. Approach to the TQ task appears to be one reasonable indicator of how students process and store knowledge acquired in their everyday lives and may be a useful predictor of how they will process the knowledge acquired during medical training. The TQ task can be fitted into one slot of a mini medical interview. © 2015 John Wiley & Sons Ltd.

  16. Chapter Twenty Chapter Twenty Eight

    African Journals Online (AJOL)

    User

    more cordial relationship among members of these ethnic groups and indeed other ethnic groups in ... And this symbiotic relationship between the oral .... But unlike Ezenwa-Ohaeto, Niyi Osundare also uses lexical repetition to mark transition from one stanza to another as illustrated in 'Daughter of the Word'. I invoke. Grief.

  17. Chapter Twenty Chapter Twenty Eight

    African Journals Online (AJOL)

    User

    Ohaeto's The Voice of the. Night Masquerade and Niyi Osundare's The Word Is an Egg. Both writers draw a lot from their respective oral traditions, a phenomenon that is greatly manifested in the works under study. Thus, this paper holds that the ...

  18. Saudi Arabia: Modernity, Stability, and the Twenty-First Century Monarchy

    Science.gov (United States)

    2015-06-01

    Monarchy 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Barrett /Roby C. 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK...The JSOU Press MacDill Air Force Base, Florida 2015 Saudi Arabia: Modernity, Stability, and the Twenty- First Century Monarchy Roby C. Barrett This...Foreword Dr. Roby Barrett’s Saudi Arabia: Modernity, Stability and the Twenty-First Century Monarchy will be of interest to any reader seeking a

  19. Border Crossing in Contemporary Brazilian Culture: Global Perspectives from the Twenty-First Century Literary Scene

    Directory of Open Access Journals (Sweden)

    Cimara Valim de Melo

    2016-06-01

    Full Text Available Abstract: This paper investigates the process of internationalisation of Brazilian literature in the twenty-first century from the perspective of the publishing market. For this, we analyse how Brazil has responded to globalisation and what effects of cultural globalisation can be seen in the Brazilian literary scene, focusing on the novel. Observing the movement of the novelists throughout the globe, the reception of Brazilian literature in the United Kingdom and the relations between art and the literary market in Brazil, we intend to provoke some reflections on Brazilian cultural history in the light of the twenty-first century.

  20. Influence of food-environment interactions on health in the twenty-first century.

    OpenAIRE

    Fennema, O

    1990-01-01

    The quality and safety of foods are affected by the environment, and the quality and safety of the environment are, in turn, affected by foods and food processing. To explore these interrelationships, as they might exist in the twenty-first century, one must speculate regarding future changes in foods and food processing. Several trends in food processing seem likely to predominate into the twenty-first century, and they will be, for the most part, evolutionary in nature and of low consumer v...

  1. Coffee consumption and total mortality: a meta-analysis of twenty prospective cohort studies.

    Science.gov (United States)

    Je, Youjin; Giovannucci, Edward

    2014-04-14

    Coffee consumption has been shown to be associated with various health outcomes, but no comprehensive review and meta-analysis of the association between coffee consumption and total mortality has been conducted. To quantitatively assess this association, we conducted a meta-analysis of prospective cohort studies. Eligible studies were identified by searching the PubMed and EMBASE databases for all articles published through June 2013 and reviewing the reference lists of the retrieved articles. Pooled relative risks (RR) with 95% CI were calculated using a random-effects model. We identified twenty studies of coffee consumption and total mortality, including 129,538 cases of deaths among the 973,904 participants. The RR of total mortality for the high v. low category of coffee consumption was 0.86 (95% CI 0.80, 0.92). The pooled RR for studies using ≥ 2-4 cups/d as a cut-off for the high category was similar to that for studies using ≥ 5-9 cups/d as the cut-off. By geographical region, the inverse association tended to be stronger for the eight studies conducted in Europe (RR 0.78, 95% CI 0.70, 0.88) and three studies carried out in Japan (RR 0.82, 95% CI 0.73, 0.92) than for the nine studies conducted in the USA (RR 0.92, 95% CI 0.84, 1.00). The inverse association was similar for men (RR 0.81, 95% CI 0.73, 0.90) and women (RR 0.84, 95% CI 0.79, 0.89). A weak, but significant, inverse association was found with moderate coffee consumption (1-2 cups/d; RR 0.92, 95% CI 0.87, 0.98). High decaffeinated coffee consumption was also found to be associated with a lower risk of death, but the data are limited. Our findings indicate that coffee consumption is associated with a reduced risk of total mortality.

  2. Stable and efficient systems for the twenty-first century | Duisenberg ...

    African Journals Online (AJOL)

    Stable and efficient systems for the twenty-first century. W Duisenberg. Abstract. No Abstract. Securities Market Journal Vol. 10 (2) 2005: pp. 30-33. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · http://dx.doi.org/10.4314/smj.v10i1.39046 · AJOL African Journals Online.

  3. Twenty-first century relevance of Soyinka's A dance of the forests : a ...

    African Journals Online (AJOL)

    This article embarks on a re-reading of Wole Soyinka's A Dance of the Forests in order to determine the relevance of the play to the twenty-first century Nigerian cum African society. The re-reading is cast in a postmodern conceptualization because it attempts a deconstructive reading procedure, which reassesses and ...

  4. Way Forward in the Twenty-First Century in Content-Based Instruction: Moving towards Integration

    Science.gov (United States)

    Ruiz de Zarobe, Yolanda; Cenoz, Jasone

    2015-01-01

    The aim of this paper is to reflect on the theoretical and methodological underpinnings that provide the basis for an understanding of Content-Based Instruction/Content and Language Integrated Learning (CBI/CLIL) in the field and its relevance in education in the twenty-first century. It is argued that the agenda of CBI/CLIL needs to move towards…

  5. 78 FR 31627 - Twenty-Second Meeting: RTCA Special Committee 224, Airport Security Access Control Systems

    Science.gov (United States)

    2013-05-24

    ...: RTCA Special Committee 224, Airport Security Access Control Systems AGENCY: Federal Aviation... 224, Airport Security Access Control Systems. SUMMARY: The FAA is issuing this notice to advise the public of the twenty-second meeting of the RTCA Special Committee 224, Airport Security Access Control...

  6. 78 FR 54612 - Closed Captioning of Internet Protocol-Delivered Video Programming: Implementation of the Twenty...

    Science.gov (United States)

    2013-09-05

    ... From the Federal Register Online via the Government Publishing Office FEDERAL COMMUNICATIONS COMMISSION 47 CFR Part 79 Closed Captioning of Internet Protocol-Delivered Video Programming: Implementation of the Twenty-First Century Communications and Video Accessibility Act of 2010 AGENCY: Federal...

  7. Twenty Years of MALL Project Implementation: A Meta-Analysis of Learning Outcomes

    Science.gov (United States)

    Burston, Jack

    2015-01-01

    Despite the hundreds of Mobile-Assisted Language Learning (MALL) publications over the past twenty years, statistically reliable measures of learning outcomes are few and far between. In part, this is due to the fact that well over half of all MALL-related studies report no objectively quantifiable learning outcomes, either because they did not…

  8. Langerhans' cell histiocytosis with twenty-nail dystrophy and a rare ...

    African Journals Online (AJOL)

    We report a 2 year old female child, a product of consanguinous marriage who presented with seborrhoeic dermatitis like eruption involving scalp, twenty nail dystrophy, oral lesions and loosened teeth, mild hepatomegaly, low RBC count, multiple osteolytic lesions in skull and pelvic bones thus falling into the category of ...

  9. Twenty-One Ways to Use Music in Teaching the Language Arts.

    Science.gov (United States)

    Cardarelli, Aldo F.

    Twenty-one activities that integrate music and the language arts in order to capitalize on children's interests are described in this paper. Topics of the activities are as follows: alphabetical order, pantomime, vocabulary building from words of a favorite song, words that are "the most (whatever)" from songs, mood words, a configuration clue…

  10. 2010 Critical Success Factors for the North Carolina Community College System. Twenty First Annual Report

    Science.gov (United States)

    North Carolina Community College System (NJ1), 2010

    2010-01-01

    First mandated by the North Carolina General Assembly in 1989 (S.L. 1989; C. 752; S. 80), the Critical Success Factors report has evolved into the major accountability document for the North Carolina Community College System. This twenty first annual report on the critical success factors is the result of a process undertaken to streamline and…

  11. Twenty-first Semiannual Report of the Commission to the Congress, January 1957

    Energy Technology Data Exchange (ETDEWEB)

    Strauss, Lewis L.

    1957-01-31

    The document represents the twenty-first semiannual Atomic Energy Commission (AEC) report to Congress. The report sums up the major activities and developments in the national atomic energy program covering the period July - December 1956. A special part two of this semiannual report addresses specifically Radiation Safety in Atomic Energy Activities.

  12. Surgical excision of hypothalamic hamartoma in a twenty months old boy with precocious puberty

    Directory of Open Access Journals (Sweden)

    Rajesh K Ghanta

    2011-01-01

    Full Text Available A twenty months old boy presented to our department with true precocious puberty due to hypothalamic hamartoma. Total surgical excision of pedunculated hypothalamic hamartoma was done successfully by the pterional trans-sylvian approach as he could not afford medical management. Patient had uneventful post-operative course with normalization of serum testosterone levels and regression of secondary sexual characters.

  13. Teachers' Critical Reflective Practice in the Context of Twenty-First Century Learning

    Science.gov (United States)

    Benade, Leon

    2015-01-01

    In the twenty-first century, learning and teaching at school must prepare young people for engaging in a complex and dynamic world deeply influenced by globalisation and the revolution in digital technology. In addition to the use of digital technologies, is the development of flexible learning spaces. It is claimed that these developments demand,…

  14. Access to archives in South Africa in the first twenty years of ...

    African Journals Online (AJOL)

    Access to archives in South Africa in the first twenty years of democracy: is there transformation or deformation? ... government. The contents of the article are based on an extensive literature review. However, the author's personal professional experience in the archival field has also substantially contributed to the process.

  15. Theme: The Twenty-seventh Annual School Vision Forum and Reading Conference.

    Science.gov (United States)

    Nemeth, Joseph S., Ed.

    1974-01-01

    An account of the sessions of the twenty-seventh annual School Vision Forum and Reading Conference is included in this issue. Contents consist of the reports of the following sessions: A School Program Focused on Learning Rather Than Teaching; What Psychologists Can Contribute to Educators and Optometrists; Perceptual Clairvoyance; Empowering the…

  16. Humanities: The Unexpected Success Story of the Twenty-First Century

    Science.gov (United States)

    Davis, Virginia

    2012-01-01

    Humanities within universities faced challenges in the latter half of the twentieth century as their value in the modern world was questioned. This paper argues that there is strong potential for the humanities to thrive in the twenty-first century university sector. It outlines some of the managerial implications necessary to ensure that this…

  17. [DYNAMICS OF TWENTY-FOUR HOUR MONITORING OF BLOOD PRESSURE IN ELDERLY PATIENTS WITH BRONCHIAL ASTHMA].

    Science.gov (United States)

    Orakova, F H; Inarokova, A M; Ramazanova, K A; Semenova, I L

    2015-01-01

    Twenty-four hour blood pressure monitoring in groups of patients of elderly age with bronchial asthma and hypertension was conducted. The study showed an increased variability of blood pressure and insufficient reduction in night time that leads to development of cardiovascular complications.

  18. 78 FR 20168 - Twenty Fourth Meeting: RTCA Special Committee 203, Unmanned Aircraft Systems

    Science.gov (United States)

    2013-04-03

    ...: Meeting Notice of RTCA Special Committee 203, Unmanned Aircraft Systems. SUMMARY: The FAA is issuing this... Document--Operational Functional Requirements and Safety Objectives for Unmanned Aircraft Systems and... Federal Aviation Administration Twenty Fourth Meeting: RTCA Special Committee 203, Unmanned Aircraft...

  19. Intellectual Freedom and Libraries: Complexity and Change in the Twenty-First-Century Digital Environment

    Science.gov (United States)

    Dresang, Eliza T.

    2006-01-01

    What is the state of intellectual freedom and libraries in the early twenty-first-century digital environment? This question is addressed largely in relation to public and school libraries, where more than 90 percent of documented challenges exist and at which most legislative and judicial actions relevant to intellectual freedom and libraries are…

  20. The nature of intractable conflict: Resolution in the twenty-first century

    African Journals Online (AJOL)

    Book review. The nature of intractable conflict: Resolution in the twenty-first century. Christopher Mitchell* 2014. New York, Palgrave Macmillan, 353 pages. ... three, where he indicates the necessity for organising conflicts into various required ... conflicts should be waged, chapter seven addresses the specific rule systems ...

  1. Reflections on the first twenty-five years of the University of Malawi ...

    African Journals Online (AJOL)

    the Flinders University of South Australia), and South Africa. (the University of Cape Town), where they had gone for part of their medical studies. The chronology of events and the rationale for this hybrid training have been previously described.3-5. Reflections on the first twenty-five years of the. University of Malawi College ...

  2. Twenty-Seven Months - Intifada, Closures, and Palestinian Economic Crisis : An Assessment

    OpenAIRE

    World Bank

    2003-01-01

    "Twenty-Seven Months - Intifada, Closures and Palestinian Economic Crisis: An Assessment" was prepared as a follow-up to a report published in March 2002 ("Fifteen Months - Intifada, Closures and Palestinian Economic Crisis" report no. 24931). The main objectives of this second Assessment are once again to help donors and the Palestinian Authority (PA) cope with the deep economic crisis in...

  3. TPACK Updated to Measure Pre-Service Teachers' Twenty-First Century Skills

    Science.gov (United States)

    Valtonen, Teemu; Sointu, Erkko; Kukkonen, Jari; Kontkanen, Sini; Lambert, Matthew C.; Mäkitalo-Siegl, Kati

    2017-01-01

    Twenty-first century skills have attracted significant attention in recent years. Students of today and the future are expected to have the skills necessary for collaborating, problem solving, creative and innovative thinking, and the ability to take advantage of information and communication technology (ICT) applications. Teachers must be…

  4. Movies to the Rescue: Keeping the Cold War Relevant for Twenty-First-Century Students

    Science.gov (United States)

    Gokcek, Gigi; Howard, Alison

    2013-01-01

    What are the challenges of teaching Cold War politics to the twenty-first-century student? How might the millennial generation be educated about the political science theories and concepts associated with this period in history? A college student today, who grew up in the post-Cold War era with the Internet, Facebook, Twitter, smart phones,…

  5. A twenty-year review of policy landscape for gender-based violence ...

    African Journals Online (AJOL)

    The struggle for liberation, equity and equality in South Africa has come a long way to the point where South Africa has celebrated twenty years of democracy in 2014. Substantive advancements have been made towards a constitutional framework and domestic policy that is transformational, progressive and empowering.

  6. EXOGENOUS CHALLENGES FOR THE TOURISM INDUSTRY IN THE BEGINNING OF THE TWENTY FIRST CENTURY

    Directory of Open Access Journals (Sweden)

    Akosz Ozan

    2009-05-01

    Full Text Available Tourism is one of the fastest growing industries in the world. Besides its sustained growth the tourism industry has shown in the first years of the twenty first century that it can deal with political, military and natural disasters. The present paper ac

  7. Philosophy and Methods for China's Vocational Education Curriculum Reforms in the Early Twenty-First Century

    Science.gov (United States)

    Xu, Guoqing

    2014-01-01

    Curriculum reform is an important aspect of progress in China's vocational education in the twenty-first century. The past decade's round of reforms were unprecedented in China in terms of both the scope and depth of their impact. They have and will continue to dramatically alter the nation's vocational education curriculum and teaching methods.…

  8. The conundrum of religious schools in twenty-first-century Europe

    NARCIS (Netherlands)

    Merry, M.S.

    2015-01-01

    In this paper Merry examines in detail the continued - and curious - popularity of religious schools in an otherwise ‘secular’ twenty-first century Europe. To do this he considers a number of motivations underwriting the decision to place one's child in a religious school and delineates what are

  9. Education for Future-Oriented Citizenship: Implications for the Education of Twenty-First Century Competencies

    Science.gov (United States)

    Lee, Wing On

    2012-01-01

    Globalization and the knowledge economy have opened up worldwide agendas for national development. Following this is the emphasis on the social dimension, otherwise known as social capital. Much of social capital includes "soft skills" and "twenty-first century skills", which broadly cover critical, creative and inventive…

  10. The «Group of Twenty», IMF and EU and Reforming of Global Governance

    Directory of Open Access Journals (Sweden)

    Evgeniy J. Il'in

    2014-01-01

    Full Text Available This article is devoted to the process of reforming the global financial system and world economic organizations since the foundation of the International Monetary Fund at the Bretton Woods Conference in 1944 to present time. Special attention is given to results of cooperation of the IMF and the "Group of Twenty"in the context of the world financial crisis 2008-2009. This article mentions the key benchmarks of the historical development of world economy: foundation of the Bretton Woods financial system, rejection of the gold standard at the Jamaica Conference, transition to the floating exchange rates, the wave of crises in the 1990-s, the world financial crisis of 2008-2009. The process of evolution of the IMF within the framework of these global events is considered here. The cooperation of EU, IMF and "Group of Twenty" is considered. The reforms of the IMF and their results are analyzed. The policy of the IMF at different historical stages of its evolution is estimated. As well as it results, the article also deals with the formation and development of the "Group of Twenty". The increasing role of the "Group of Twenty" in the global economic governance and reforming the IMF is considered. Especially is marked the necessity of the further reforms of the IMF and increasing of participation of the "G-20" in the world economic and politic system.

  11. Affective and cognitive determinants of intention to consume twenty foods that contribute to fat intake

    NARCIS (Netherlands)

    Stafleu, A.; Graaf, de C.; Staveren, van W.A.; Burema, J.

    2001-01-01

    Fishbein and Ajzen's theory of reasoned action was used as a framework to study beliefs and attitudes towards twenty foods that contribute to fat intake in a Netherlands smaple population. Subjects between 18 and 75 years of age (n = 419, response rate 23€filled out a self-administered

  12. METHYLMERCURY BIOACCUMULATION DEPENDENCE ON NORTHERN PIKE AGE AND SIZE IN TWENTY MINNESOTA LAKES

    Science.gov (United States)

    Mercury accumulation in northern pike muscle tissue (fillets) was found to be directly related to fish age and size. Measurements were made on 173 individual northern pike specimens from twenty lakes across Minnesota. Best fit regressions of mercury fillet concentration (wet wt.)...

  13. Fast-food consumption among 17-year-olds in the Birth to Twenty ...

    African Journals Online (AJOL)

    Objectives: Assessment of fast-food consumption in urban black adolescents. Design: The current research was a descriptive cross-sectional study. Setting: Subjects attending the Birth to Twenty (Bt20) research facility at the Chris Hani Baragwanath Hospital in Soweto, Johannesburg between September 2007 and May ...

  14. Testing Students under Cognitive Capitalism: Knowledge Production of Twenty-First Century Skills

    Science.gov (United States)

    Morgan, Clara

    2016-01-01

    Scholars studying the global governance of education have noted the increasingly important role corporations play in educational policy making. I contribute to this scholarship by examining the Assessment and Teaching of twenty-first century skills (ATC21S™) project, a knowledge production apparatus operating under cognitive capitalism. I analyze…

  15. What history tells us VII. Twenty-five years ago: the production of ...

    Indian Academy of Sciences (India)

    2006-11-13

    Nov 13, 2006 ... Home; Journals; Journal of Biosciences; Volume 31; Issue 5. What history tells us VII. Twenty-five years ago: the production of mouse embryonic stem cells. Michel Morange. Series Volume 31 Issue 5 December 2006 pp 537-541. Fulltext. Click here to view fulltext PDF. Permanent link:

  16. 76 FR 56658 - Video Description Implementation of the Twenty-First Century Communications and Video...

    Science.gov (United States)

    2011-09-14

    ... COMMISSION 47 CFR Parts 73 and 79 Video Description Implementation of the Twenty-First Century Communications and Video Accessibility Act of 2010 Action: Final rules; announcement of effective date. SUMMARY: In... issues relating to the video description rules. The final information collection requirements were...

  17. Land and Freedom [Twenty Lessons for High School American Studies Classroom Instruction].

    Science.gov (United States)

    Rubenstein, Stan

    Twenty self-contained lessons about land and freedom feature activities that can be used with high school social studies classes. The lessons are: Indian Land Ownership, The Dutch and the New World, Colonial Mercantilism, the Declaration and Natural Rights, Jefferson and Liberty, Louisiana Purchase, the Tariff Issue of 1824, Panic of 1837, John…

  18. Forecasting Twenty-First Century Information Technology Skills: A Delphi Study

    Science.gov (United States)

    Young, Jackie A.

    2012-01-01

    As cities and regions seek to increase the stock of college educated citizens in order to compete in the twenty-first century knowledge-economy, colleges and universities are realizing increased enrollment. At the same time, much is being written about the skills needed by graduates for the new economy. These studies articulate skills in critical…

  19. Culture, Power, and the University in the Twenty-First Century

    Science.gov (United States)

    Murphy, Peter

    2012-01-01

    Powerful nations have influential systems of higher education. The article explores the possible pattern of geopolitics in the twenty-first century, and the competing prospects of America and its rivals in higher education and research. Pressures on both the American and non-American worlds are evaluated, along with relative economic strengths,…

  20. Building Collective Leadership Capacity Using Collaborative Twenty-First Century Digital Tools

    Science.gov (United States)

    James, Freddy; Figaro-Henry, Sandra

    2017-01-01

    The current research explores how using collaborative twenty-first century digital tools developed the collective leadership capacity among participants in an educational leadership course. A qualitative interpretive approach was used. The data show how learning within the digital collaborative spaces was multidirectional and enhanced the…

  1. Visual Literacy: Does It Enhance Leadership Abilities Required for the Twenty-First Century?

    Science.gov (United States)

    Bintz, Carol

    2016-01-01

    The twenty-first century hosts a well-established global economy, where leaders are required to have increasingly complex skills that include creativity, innovation, vision, relatability, critical thinking and well-honed communications methods. The experience gained by learning to be visually literate includes the ability to see, observe, analyze,…

  2. Twenty Years of Quality Assurance in Higher Education: What's Happened and What's Different?

    Science.gov (United States)

    Ewell, Peter

    2010-01-01

    Twenty years ago, the federal government in the US first required institutional accrediting organisations, America's principal mechanism for quality assurance in higher education, to review institutional practices with respect to the assessment of student learning outcomes. Much that affects quality assurance has changed in the ensuing two decades…

  3. Pleasantness and arousal in twenty-five positive emotions elicited by durable products

    NARCIS (Netherlands)

    Ortíz Nicolás, J.C.; Aurisicchio, M.; Desmet, P.M.A.

    2014-01-01

    This study reports quantitative research into two basic dimensions of emotions: pleasantness and arousal. Fifty-nine participants evaluated these two dimensions for a set of twenty-five positive emotions in relation to human-product interactions. Three levels of arousal were iden- tified:

  4. Why American business demands twenty-first century learning: A company perspective.

    Science.gov (United States)

    Knox, Allyson

    2006-01-01

    Microsoft is an innovative corporation demonstrating the kind and caliber of job skills needed in the twenty-first century. It demonstrates its commitment to twenty-first century skills by holding its employees accountable to a set of core competencies, enabling the company to run effectively. The author explores how Microsoft's core competencies parallel the Partnership for 21st Century Skills learning frameworks. Both require advanced problem-solving skills and a passion for technology, both expect individuals to be able to work in teams, both look for a love of learning, and both call for the self-confidence to honestly self-evaluate. Microsoft also works to cultivate twenty-first century skills among future workers, investing in education to help prepare young people for competitive futures. As the need for digital literacy has become imperative, technology companies have taken the lead in facilitating technology training by partnering with schools and communities. Microsoft is playing a direct role in preparing students for what lies ahead in their careers. To further twenty-first century skills, or core competencies, among the nation's youth, Microsoft has established Partners in Learning, a program that helps education organizations build partnerships that leverage technology to improve teaching and learning. One Partners in Learning grantee is Global Kids, a nonprofit organization that trains students to design online games focused on global social issues resonating with civic and global competencies. As Microsoft believes the challenges of competing in today's economy and teaching today's students are substantial but not insurmountable, such partnerships and investments demonstrate Microsoft's belief in and commitment to twenty-first century skills.

  5. Growing a Colony from an Outpost - The Colonization of Mars in the Twenty-Second Century

    Science.gov (United States)

    Halyard, R. J.

    Near the end of the Twenty-first Century there may be one or more permanent outposts on Mars; these outposts will recycle their water and atmosphere and remain permanently staffed. The Earth will provide crew rotation plus food supplies and replacement equipment approximately every one and one-half years. Assuming that the permanent outposts are located near deposits of frozen water and necessary minerals, the potential exists of expanding these outposts to a small, self-sufficient colony. Additional equipment, structures and personnel plus changes in operations will be required to make the expansion to a colony possible. Because many variables and assumptions exist in the determination of the additional hardware, the resulting proposed colony design is very tentative and provides only as an initial estimate of the effort required. However if the assumptions are met and the equipment indicated developed, it should definitely be possible to establish a Mars colony in the early Twenty-second Century.

  6. How are social changes in the twenty first century relevant to mental health?

    Directory of Open Access Journals (Sweden)

    Krishna M Prasad

    2016-01-01

    Full Text Available Mental health problems occur in a psychosocial context. Social dimensions significantly impact psychiatric practice and research. The twenty first century has seen dramatic urbanization, globalization, rapid advances in technology, and communications. These among several other social changes, such as nature and shift in family systems, newer patterns of relationships, migration, and social mobility will bring about novel challenges for diagnosing and managing mental health problems; nevertheless this may at the same time throw newer means and opportunities to intervene, particularly with the advancements in technology. There is likely to be greater awareness about mental health problems. The rights based and recovery oriented approaches will change the way psychiatry is practiced. Many of these changes will positively impact policies of the government and access to care. This article focuses on the social changes in the twenty first century and the impact this has had and will have on mental health, especially in India.

  7. The post irradiation examinations of twenty-years stored spent fuel

    Energy Technology Data Exchange (ETDEWEB)

    Sasahara, A.; Matsumura, T. [Central Research Institute of Electric Power Industry, Tokyo (Japan)

    2000-07-01

    The post irradiation examinations (PIE) on the twenty years stored spent fuels were carried out to evaluate fuel integrity during storage. The spent BWR-MOX fuel rods and PWR-UO{sub 2} fuel rod irradiated in commercial LWR were used. The burnup of the BWR-MOX fuels (five fuel rods) are about 20 GWd/t and that of the PWR-UO{sub 2} fuel is 58 GWd/t. PIE items in this study are, a) visual inspection of the cladding surface, b) puncture test or gas analysis in capsule, c) ceramographic examination to observe oxide layer thickness on outside/inside cladding and pellet microstructure such as grain size, d) electron probe microanalysis (EPMA) on pellet, e) hydrogen content in cladding. The preliminary result shows that twenty years stored fuel rods were not different from that before storage. (authors)

  8. In Search of a Twenty-First-Century Air-Leadership Model: Fodder for Your Professional Reading

    Science.gov (United States)

    2001-01-01

    In Search of a Twenty-First-Century Air- Leadership Model Fodder for Your Professional Reading DR. DAVID R. METS* Editorial Abstract: Where can...Twenty-First-Century Air- Leadership Model . Fodder for Your Professional Reading 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6...Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 IN SEARCH OF A TWENTY-FIRST-CENTURY AIR- LEADERSHIP MODEL 41 tions hold that airmen are

  9. Looking backward, 1984-1959: twenty-five years of library automation--a personal view.

    Science.gov (United States)

    Pizer, I H

    1984-01-01

    A brief profile of Janet Doe is given. Twenty-five years of library automation are reviewed from the author's point of view. Major projects such as the SUNY Biomedical Communication Network and the Regional Online Union Catalog of the Greater Midwest Regional Medical Library Network are discussed. Important figures in medical library automation are considered, as is the major role played by the National Library of Medicine. Images PMID:6388691

  10. The interrelation of twenty-first-century education and work from a gender perspective

    OpenAIRE

    Kupfer, Antonia

    2014-01-01

    This paper analyses the interrelation of twenty-first-century education and work from a gender perspective. The analysis is carried out theoretically by asking whether human capital theory and Bourdieu's reproduction theory are adequate instruments for such an endeavour. It is argued that the explanatory power of the human capital concept of the interrelation between education and work is extremely weak, because the human capital concept conceals costs necessary to create human capital. In co...

  11. The Twenty-Four Month Command Tour: Is It the Optimum Length?

    Science.gov (United States)

    1990-05-15

    another. As Christina Maslach points out, "There is no single definition of burnout that is accepted as a standard." She offers some twenty or so...system, supporting the desire for former battalion commanders to serve in certain jobs, minimizing commander stress and burnout , and facilitating the...mentioned " burnout " 18 or some related term. Some used such words as "tired" or "stress." Others specifically discussed the toll the command tour takes

  12. Preparation of European Public Health Professionals in the Twenty-first Century

    OpenAIRE

    Bjegovic-Mikanovic, Vesna; Otok, Robert

    2017-01-01

    The public health profession in Europe has a leadership role for ensuring European’s health in the twenty-first century and therefore must assume responsibility for advancing education for research and practice. Three fundamental questions are explored: (1) What are the main public health problems facing public health professionals; (2) What are their existing competencies after training; and (3) What competencies do European employers expect? The European Schools of Public Health assessed th...

  13. Irrigation quality of ground water of twenty villages in Lahore district

    Directory of Open Access Journals (Sweden)

    M.S. Ali

    2009-05-01

    Full Text Available study was conducted in twenty villages of Lahore district to assess the suitability of ground water for irrigation. Three water samples were collected from each of twenty villages and were analyzed for electrical conductivity (EC, sodium adsorption ratio (SAR, residual sodium carbonate (RSC and chloride concentration. Out of total 60 water samples, 7 (11.7% were fit, 7 (11.7% were marginally fit, and remaining 46 (76.6% were unfit for irrigation. Twenty eight samples (46.6% had electrical conductivity higher than permissible limit (i.e. >1250 µS cm-1, 19 samples (31.6% were found with high SAR (i.e. >10 (m mol L-10. 5, 44 samples (73.3% had high RSC (i.e. >2.5 me L-1 and 10 samples (16.6% were found unfit for irrigation due to high concentration of chloride (i.e. >3.9 me L-1. It can be inferred from data that quality of available ground water in most ofthe villages is not suitable for sustainable crop production and soil health.

  14. Complex responsive processes: a new lens for leadership in twenty-first-century health care.

    Science.gov (United States)

    Davidson, Sandra Jean

    2010-01-01

    Health care is currently in the midst of an age change. Leadership styles and organizational structures that were prevalent in the twentieth century no longer apply in twenty-first-century health care. Leaders of health care must embrace and help others to embrace new ways of being and relating in twenty-first-century organizations. This paper introduces a new framework through which leaders can see their organizations differently. Complex responsive processes (CRPs) focus on the interactions between people that take place in the living present as the building block of transformative organizations. This paper also introduces the seven da Vincian principles as a personal tool that twenty-first-century leaders might use to increase their capacity for creativity and to develop their ability to thrive in uncertainty. The power to shape the preferred future of health care lies within our relationships with others that take place locally and in the living present. Viewing organizations through the lens of CRPs and developing practices around the seven da Vincian principles provides directions and a starting point for traditional leaders to move away from rationalist, twentieth-century practices toward transformative leadership practices.

  15. Chloracne, goiter, arthritis, and anemia after polychlorinated biphenyl poisoning: 14-year follow-Up of the Taiwan Yucheng cohort.

    OpenAIRE

    Guo, Y L; Yu, M L; Hsu, C.C.; Rogan, W J

    1999-01-01

    In 1979, a mass poisoning involving 2,000 people occurred in central Taiwan from ingestion of cooking oil contaminated by polychlorinated biphenyls (PCBs) and polychlorinated dibenzofurans (PCDFs). We studied the prevalence of medical conditions in the exposed individuals and in a neighborhood control group. Starting with a registry of the exposed individuals from 1983, we updated the addresses of exposed individuals and identified a control group matched for age, sex, and neighborhood in 197...

  16. Kawasaki disease: a rare pediatric pathology in Mexico. Twenty cases report from the Hospital Infantil del Estado de Sonora.

    Science.gov (United States)

    Sotelo, Norberto; González, Luis Antonio

    2007-01-01

    Kawasaki disease (KD) is an etiological illness that is relatively unknown and scarcely identified in Mexico; it affects children mainly aged 1-4 years, evolves with fever, vasculitis in diverse organs, and in the heart the disease mainly affects the coronary arteries. Our aim was to inform the clinical findings and evolution of 20 patients diagnosed with KD. We reviewed the patient clinical files retrospectively and descriptively to obtain information with regard to age, sex, clinical signs, laboratory and consultory results, echocardiography findings, complications, evolution during hospitalization, followup, and out-patient ambulatory consultations. Eighteen patients were male, two were female, six developed coronary damage, two aortic mitral-valve insufficiency, one pericardial shedding, and one, myocarditis. All patients received gamma globulin treatment with aspirin, and 16 were controlled during 6-8 months after the acute medical profile. The opportune clinical diagnostic it is fundamental to establish an early treatment with gammmaglobuline to avoid injuries in the arterial coronary level. This injury may cause eventualy ischemia or myocardial infarct

  17. [Capitolunate arthrodesis with tension band wire in wrist arthritis: twenty cases with four year follow-up].

    Science.gov (United States)

    Durand, A; Harisboure, A; Nurbel, B; Lawane, M; Grenier de Cardenal, D; Giraud, B; Kassouma, J; Dehoux, E

    2007-02-01

    Treatment of degenerative osteoarthritis of the wrist is aimed at preserving wrist motion and force while reducing pain. Limitation of the degenerative processes to certain joints raises the possibility of intracarpal arthrodesis, e.g. capitolunate arthrodesis. We present results of this procedure with a tension band wire in patients with arthritic degenerative disease of the wrist. The series included 20 patients reviewed at mean 47 months. Mean age was 53.5 years. Pain was the main complaint. Wrist force and motion were decreased in all patients. All patients presented osteoarthritic disease of the wrist with preservation of the radiolunate space. The operation consisted in total scaphoidectomy and capitolunate arthrodesis maintained with a tension band wire. Force, pain (Mayo clinic score) and force (Jamar dynamometer) were recorded. The Cooney function score was determined and six patients completed the French Dash questionnaire. Radiolunate and capitolunate angles were noted as well as the index of carpal height measured preoperatively and at last follow-up. Nineteen of the 20 arthrodeses fused. A revision graft was successful for the one nonunion. Pain was the only clinical factor which improved significantly (pwrist with a preserved radiolunate space. We prefer this procedure to four-way arthrodesis because useful motion and wrist force are preserved with constant and effective significant pain relief.

  18. A Singapore Case Study of Curriculum Innovation in the Twenty-First Century: Demands, Tensions and Deliberations

    National Research Council Canada - National Science Library

    Koh, Elizabeth; Ponnusamy, Letchmi Devi; Tan, Liang See; Lee, Shu-Shing; Ramos, Maria Eloisa

    2014-01-01

    ... and practices to be relevant. In Singapore’s centralized education system, the Ministry has introduced several decentralization initiatives in the hope of promoting flexibility and innovation within schools...

  19. Bits, Bytes and Dinosaurs: Using Levinas and Freire to Address the Concept of "Twenty-First Century Learning"

    Science.gov (United States)

    Benade, Leon

    2015-01-01

    The discourse of twenty-first century learning argues that education should prepare students for successful living in the twenty-first century workplace and society. It challenges all educators with the idea that contemporary education is unable to do so, as it is designed to replicate an industrial age model, essentially rear-focused, rather than…

  20. Review of Twenty-First Century Portable Electronic Devices for Persons with Moderate Intellectual Disabilities and Autism Spectrum Disorders

    Science.gov (United States)

    Mechling, Linda C.

    2011-01-01

    Use of portable electronic devices by persons with moderate intellectual disabilities and autism spectrum disorders is gaining increased research attention. The purpose of this review was to synthesize twenty-first century literature (2000-2010) focusing on these technologies. Twenty-one studies were identified which evaluated use of: (a) handheld…

  1. Why American business demands twenty-first century skills: an industry perspective.

    Science.gov (United States)

    Bruett, Karen

    2006-01-01

    Public education is the key to individual and business prosperity. With a vested stake in education, educators, employers, parents, policymakers, and the public should question how this nation's public education system is faring. Knowing that recent international assessments have shown little or no gains in American students' achievement, the author asserts the clear need for change. As both a large American corporate employer and a provider of technology for schools, Dell is concerned with ensuring that youth will thrive in their adult lives. Changing workplace expectations lead to a new list of skills students will need to acquire before completing their schooling. Through technology, Dell supports schools in meeting educational goals, striving to supply students with the necessary skills, referred to as twenty-first century skills. The Partnership for 21st Century Skills, of which Dell is a member, has led an initiative to define what twenty-first century learning should entail. Through extensive research, the partnership has built a framework outlining twenty-first century skills: analytical thinking, communication, collaboration, global awareness, and technological and economic literacy. Dell and the partnership are working state by state to promote the integration of these skills into curricula, professional development for teachers, and classroom environments. The authors describe two current initiatives, one in Virginia, the other in Texas, which both use technology to help student learning. All stakeholders can take part in preparing young people to compete in the global economy. Educators and administrators, legislators, parents, and employers must play their role in helping students be ready for what the workforce and the world has in store for them.

  2. Effects of energy constraints on transportation systems. [Twenty-six papers

    Energy Technology Data Exchange (ETDEWEB)

    Mittal, R. K. [ed.

    1977-12-01

    Twenty-six papers are presented on a variety of topics including: energy and transportaton facts and figures; long-range planning under energy constraints; technology assessment of alternative fuels; energy efficiency of intercity passenger and freight movement; energy efficiency of intracity passenger movement; federal role; electrification of railroads; energy impact of the electric car in an urban enviroment; research needs and projects in progress--federal viewpoint; research needs in transportation energy conservation--data needs; and energy intensity of various transportation modes--an overview. A separate abstract was prepared for each of the papers for inclusion in Energy Research Abstracts (ERA) and in Energy Abstracts for Policy Analysis (EAPA).

  3. `Dear Professor Dyson': Twenty years of correspondence between Freeman Dyson and undergraduate students

    Science.gov (United States)

    Neuenschwander, Dwight E.

    2014-03-01

    For twenty years the students in my "Science, Technology, and Society" course, where we use Disturbing the Universe as a textbook, have corresponded with Professor Dyson. That someone of Professor Dyson's standing consistently makes a priority of promptly answering the letters of undergraduate students from all academic majors, and does so with grace and kindness, insight and wisdom, offers a personal glimpse into his character and integrity. On behalf of my students, and as a way of publicly thanking Professor Dyson for participating in our course conversations, I am honored to share samples of our correspondence with him over the years, including student reflections on his involvement in their education.

  4. `DEAR Professor DYSON:' Twenty Years of Correspondence Between Freeman Dyson and Undergraduate Students

    Science.gov (United States)

    Neuenschwander, Dwight E.

    2014-04-01

    For twenty years the students in my "Science, Technology, and Society" course, where we use Disturbing the Universe as a textbook, have corresponded with Professor Dyson. That someone of Professor Dyson's standing consistently makes a priority of promptly answering the letters of undergraduate students from all academic majors, and does so with grace and kindness, insight and wisdom, offers a personal glimpse into his character and integrity. On behalf of my students, and as a way of publicly thanking Professor Dyson for participating in our course conversations, I am honored to share samples of our correspondence with him over the years, including student reflections on his involvement in their education.

  5. Managing the twenty-first century reference department challenges and prospects

    CERN Document Server

    Katz, Linda S

    2014-01-01

    Learn the skills needed to update and manage a reference department that efficiently meets the needs of clients today?and tomorrow! Managing the Twenty-First Century Reference Department: Challenges and Prospects provides librarians with the knowledge and skills they need to manage an effective reference service. Full of useful and practical ideas, this book presents successful methods for recruiting and retaining capable reference department staff and management, training new employees and adapting current services to an evolving field. Expert practitioners address the changing role of the r

  6. Twenty-five years of post-Bretton Woods experience: some lessons

    Directory of Open Access Journals (Sweden)

    H. ASKARI

    1999-03-01

    Full Text Available In 1971 many academic economists were predicting that the Bretton Woods system of fixed parities would collapse. Some, most notably Milton Friedman, became excited about the possibility of a floating system because the benefits of international capital mobility can only be achieved through the flexibility in the exchange rate. These economists argued that a floating exchange rate system can ensure positive results more than the fixed parities system. Twenty-five years later, however, there is still no consensus on the matter. The author reviews the post-Bretton Woods experience to highlight some policies and approaches that might be helpful for the future.

  7. Twenty years of „post-communism”: the radiography of a political failure

    Directory of Open Access Journals (Sweden)

    Aurora Martin

    2011-11-01

    Full Text Available This empirical view on the current „state” of Romania has as main objective to emphasize that the contemporary economic crisis actually revealed some other escalated crises in the very heart of the Romanian society. The vicious circle determined by three crises – one political, another social-institutional and last, but not least, a cultural one, continuously weakened the state for the last twenty years. Romania will overcome the economic crisis but the key for walking out of the above-mentioned circle would be the real transformation of its core systems – political, institutional and educational.

  8. Neurogenetics in Child Neurology: Redefining a Discipline in the Twenty-first Century.

    Science.gov (United States)

    Kaufmann, Walter E

    2016-12-01

    Increasing knowledge on genetic etiology of pediatric neurologic disorders is affecting the practice of the specialty. I reviewed here the history of pediatric neurologic disorder classification and the role of genetics in the process. I also discussed the concept of clinical neurogenetics, with its role in clinical practice, education, and research. Finally, I propose a flexible model for clinical neurogenetics in child neurology in the twenty-first century. In combination with disorder-specific clinical programs, clinical neurogenetics can become a home for complex clinical issues, repository of genetic diagnostic advances, educational resource, and research engine in child neurology.

  9. New electricity 21: power industry technology and management strategies for the twenty-first century

    Energy Technology Data Exchange (ETDEWEB)

    1993-01-01

    110 papers are presented in sections entitled: keynote addresses; utility management and decision-making in a changing environment; economic and financial aspects; policy and regulatory issues; power generation technologies for the next ten to twenty years; new power generation technologies for the longer term; progress in technologies for electricity transmission and distribution; advanced technologies for information, telecommunication and control; advances in electric demand-side management and end-use; special forum on electric technology development and international co-operation for meeting global environmental challenges; and rapporteurs' reports. 29 papers have been abstracted separately.

  10. Twenty natural organic pigments for application in dye sensitized solar cells

    Science.gov (United States)

    Castillo, D.; Sánchez Juárez, A.; Espinosa Tapia, S.; Guaman, A.; Obregón Calderón, D.

    2016-09-01

    In this work we present the results of a study of twenty natural pigments obtained from plants and insects from southern Ecuador. Many of them will be considered as a potential natural sensitizer for the construction of DSSCs. The results indicate that these pigments have a good performance in the absorbance and wavelength spectra. Were selected four best pigments for the construction of DSSCs, Rumex tolimensis Wedd, Raphanus sativus, Hibiscus sabdariffa, and Prunus serótina, however the conversion efficiency is lower than 1%.

  11. Twenty of China's best physics PhD students visited CERN

    CERN Multimedia

    2006-01-01

    Twenty of the top physics PhD students in China were honoured with the 'E=mc2 to modern science' Einstein Award and received a three week tour of major laboratories in Germany and Switzerland, including CERN, DESY and the Max Planck Institute. The Einstein Award is co-sponsored by the German and Swiss Embassies in celebration of the 'Year of Physics' in 2005. For many years, Germany, Switzerland and China have been involved in numerous areas of scientific research and cooperation.

  12. Lithuanian Film Industries in Twenty-First Century: State Supported Art or Business?

    Directory of Open Access Journals (Sweden)

    Tomas Mitkus

    2011-10-01

    Full Text Available The purpose of this article is to analyse  cultural and economic aspects of Lithuanian film industry in the twenty-first century. The article discusses the film  industry‘s  cultural, symbolic and economic capital. To achieve the study objectives and determine the viewer’s attitude towards the national film industry, a quantitative questionnaire survey involving 448 people was carried out. The survey results show that the average viewer believes that Lithuania’s creators do not take into account their needs and do not create a strong marketing  activity. 

  13. Proceedings of Twenty-Seventh Annual Institute on Mining Health, Safety and Research

    Energy Technology Data Exchange (ETDEWEB)

    Bockosh, G.R. [ed.] [Pittsburgh Research Center, US Dept. of Energy (United States); Langton, J. [ed.] [Mine Safety and Health Administration, US Dept. of Labor (United States); Karmis, M. [ed.] [Virginia Polytechnic Institute and State University. Dept. of Mining and Minerals Engineering, Blacksburg (United States)

    1996-12-31

    This Proceedings contains the presentations made during the program of the Twenty-Seventh Annual Institute on Mining Health, Safety and Research held at Virginia Polytechnic Institute and State University, Blacksburg, Virginia, on August 26-28, 1996. The Twenty-Seventh Annual Institute on Mining, Health, Safety and Research was the latest in a series of conferences held at Virginia Polytechnic Institute and State University, cosponsored by the Mine Safety and Health Administration, United States Department of Labor, and the Pittsburgh Research Center, United States Department of Energy (formerly part of the Bureau of Mines, U. S. Department of Interior). The Institute provides an information forum for mine operators, managers, superintendents, safety directors, engineers, inspectors, researchers, teachers, state agency officials, and others with a responsible interest in the important field of mining health, safety and research. In particular, the Institute is designed to help mine operating personnel gain a broader knowledge and understanding of the various aspects of mining health and safety, and to present them with methods of control and solutions developed through research. Selected papers have been processed separately for inclusion in the Energy Science and Technology database.

  14. Isolated lateral meniscectomy. A study of twenty-six patients with isolated tears.

    Science.gov (United States)

    Yocum, L A; Kerlan, R K; Jobe, F W; Carter, V S; Shields, C L; Lombardo, S J; Collins, H R

    1979-04-01

    To better define the role that the lateral meniscus plays in stabilizing the knee, a study was made of twenty-six patients who had an uncomplicated lateral meniscectomy between 1972 and 1977. Patients with any degree of ligament instability, cruciate or collateral, prior to lateral meniscectomy were eliminated from the study. Also eliminated were any patients with roentgenographic evidence of degenerative arthrits, osteochondritis dissecans, or loose bodies. Only patients whose operative reports stated that the articular cartilage of the lateral compartment was either grossly normal or showed Grade-1 chondromalacia (less than one centimeter in diameter and only softening of the cartilage) at the time of surgery were included in the review. The meniscal lesions included bucket-handle tears, horizontal cleavage tears, and multiple linear defects. No grossly cystic menisci were included in the study. Two menisci demonstrated cystic degenerative changes on histological section. In sixteen patients some degree of ligament instability developed. The longer the interval between injury to the meniscus and its excision, the less satisfactory the result. Only fifteen (54 per cent) of the patients reported satisfactory results, and twenty lost some motion of the knee. We concluded that stability of the knee joint is a multifactorial problem, in which the lateral meniscus certainly plays an important part.

  15. Alterations in Salivary Proteome following Single Twenty-Minute Session of Yogic Breathing

    Directory of Open Access Journals (Sweden)

    Sundaravadivel Balasubramanian

    2015-01-01

    Full Text Available Yogic breathing (YB has been suggested to reduce stress and blood pressure and increase cognitive processes. However, alterations after YB at the molecular level are not well established. Twenty healthy volunteers were randomized into two groups (N=10 per group: YB or attention controls (AC. The YB group performed two YB exercises, each for ten minutes, for a total of twenty minutes in a single session. AC group read a text of their choice for 20 minutes. Saliva was collected at baseline and at 5, 10, 15, and 20 minutes. Using Mass Spectrometry (MS, we initially found that 22 proteins were differentially expressed and then validated deleted in malignant brain tumor-1 (DMBT1 and Ig lambda-2 chain C region (IGLC2 using Western Blotting. DMBT1 was elevated in 7 of YB group by 10-fold and 11-fold at 10 and 15 minutes, respectively, whereas it was undetectable in the time-matched AC group (P<0.05. There was a significant interaction between groups and time assessed by two-way ANOVA (P<0.001. IGLC2 also showed a significant increase in YB group as measured by Western Blotting. These data are the first to demonstrate the feasibility of stimulating and detecting salivary protein biomarkers in response to an acute Yoga exercise. This trial is registered with ClincalTrials.gov NCT02108769.

  16. [Simultaneous determination of twenty-one organic acids in food by ion chromatography with eluent autogeneration].

    Science.gov (United States)

    Lin, Huaying; Lin, Fenghua; Sheng, Lina; Li, Yidan; Zhang, Qiong

    2007-01-01

    A novel ion chromatographic method was developed for the simultaneous determination of organic acids in food samples including quinic acid, acetic acid, pyruvic acid, ketosuccinic acid, mannitic acid, lactic acid, succinic acid, malic acid, tartaric acid, oxalic acid, fumaric acid, ascorbic acid, alpha-ketoglutaric acid, cinnamic acid, salicylic acid, citric acid, isocitric acid, ferulic acid, cis-aconitic acid, trans-aconitic acid, beta-coumaric acid. 5 - 34 mmol/L KOH produced by an EG40 eluent autogenerator could achieve a flat baseline and lower background conductance when performing gradient elution. The flow rate was 0.6 - 2.5 mL/min and the injection volume was 25 microL. The separation was performed on an IonPac AS11 column and detected by suppressed conductivity with self-regenerating suppressor mode. The samples were prepared through extraction, decoloration and filtration before analysis. Twenty-one organic acids showed good linear relationship between the mass concentration and the peak area in the measurement ranges. The correlation coefficients were above 0.999 and the detection limits were 0.011 - 0.188 mg/L, and the average recoveries were 91.5% - 101.8%. The method is simple and rapid with good accuracy and reproducibility, and has been applied to determine twenty-one organic acids in diversiform samples with satisfactory results.

  17. The Summit of «Group of Twenty» – 2016: geopolitical assessments

    Directory of Open Access Journals (Sweden)

    O. S. Vonsovych

    2016-08-01

    Full Text Available The article investigated the geopolitical assessments of the results of the Summit of «Group of Twenty», which took place in Hangzhou from 4 till 5 September, 2016. The main idea of this event was the development of  innovation, healthy, coherent and inclusive economy. Moreover, important for the geopolitical consolidation of efforts of member countries in the context of further development of the world economy was making such documents as: Contours of the innovative growth of «Group of Twenty», Action plan of «Group of Twenty» in connection with a new industrial revolution, Hangzhou action plan, which set out a strategy for overall and confident growth and also initiative of «Group of twenty» in development and cooperation in the field of digital economy. Important thing is that analysis of the Summit’s results for world regions is important from a geopolitical point of view. We can predict that in the future geopolitical dialogue between the EU and the US in the economy will become more vital for both sides, and will enable to contribute to the implementation of more global challenges of the global economy. We should mention that Summit of «Group of Twenty» largely determined the prospects of global economic processes and build a new world economic order with the introduction of innovative approaches and elements of the digital economy. Activity on the functioning of the global economy should be based on the collective efforts of all participants and take into account all the realities on the international stage. No less important is that the Summit proved the presence of leading geopolitical centers that affect not only the balance of power in the world, but also the further development of key economic processes. Each of these centers sees its future not only the global economy but the global system as a whole as well as its geopolitical influence in certain regions and countries. On the one hand, as for the development of

  18. Normal Health-Related Quality of Life and Ability to Work Twenty-nine Years After in Situ Arthrodesis for High-Grade Isthmic Spondylolisthesis.

    Science.gov (United States)

    Joelson, Anders; Hedlund, Rune; Frennered, Karin

    2014-06-18

    The purpose of this mixed prospective and retrospective case series was to evaluate the long-term health-related quality of life and physical disability after in situ arthrodesis for high-grade isthmic spondylolisthesis. Thirty-five of forty consecutive patients who had in situ spinal arthrodesis for high-grade isthmic spondylolisthesis at a mean age of fifteen years (range, nine to twenty-five years) completed validated questionnaires (Short Form-36 [SF-36], EuroQol-5 Dimensions [EQ-5D], Zung depression scale, Oswestry disability index [ODI], Million score, and back and leg pain visual analog scale [VAS]) and underwent physical examination twenty-nine years (range, twenty-three to thirty-five years) after surgery. The mean age at the time of follow-up was forty-three years (range, thirty-seven to fifty-one years). In the absence of a formal control group, the scores on the SF-36 and EQ-5D were compared with Swedish normative data. The proportion of patients at work was compared with an age-matched control group derived from official statistics of Sweden. The Million score at the long-term follow-up was compared with the corresponding results at the mid-term follow-up of the same patients at a mean age of twenty-two years. The scores on the SF-36 and EQ-5D were similar to the scores of the general Swedish population. The mean Zung depression scale score was 30 (range, 20 to 52), the mean ODI score was 10 (range, 0 to 34), the mean back pain VAS score was 13 (range, 0 to 72), and the mean leg pain VAS score was 9 (range, 0 to 60). The Million score averaged 28 (range, 0 to 109) and was slightly worsened compared with the score of 19 (range, 0 to 94) at the mid-term follow-up (p = 0.034). The proportion of patients at work was the same as that for the age-matched general Swedish population. Our study shows good outcomes in health-related quality of life, disability, pain, and ability to work at up to twenty-nine years after in situ lumbar spine arthrodesis for high

  19. The Design and Performance of a Twenty Barrel Hydrogen Pellet Injector for Alcator C-Mod

    Science.gov (United States)

    Urbahn, John A.

    A twenty barrel hydrogen pellet injector has been designed, built and tested both in the laboratory and on the Alcator C-Mod Tokamak at MIT. The injector functions by firing pellets of frozen hydrogen or deuterium deep into the plasma discharge for the purpose of fueling the plasma, modifying the density profile and increasing the global energy confinement time. The design goals of the injector are: (1) Operational flexibility, (2) High reliability, (3) Remote operation with minimal maintenance. These requirements have led to a single stage, pipe gun design with twenty barrels. Pellets are formed by in-situ condensation of the fuel gas, thus avoiding moving parts at cryogenic temperatures. The injector is the first to dispense with the need for cryogenic fluids and instead uses a closed cycle refrigerator to cool the thermal system components. The twenty barrels of the injector produce pellets of four different size groups and allow for a high degree of flexibility in fueling experiments. Operation of the injector is under PLC control allowing for remote operation, interlocked safety features and automated pellet manufacturing. The injector has been extensively tested and shown to produce pellets reliably with velocities up to 1400 m/sec. During the period from September to November of 1993, the injector was successfully used to fire pellets into over fifty plasma discharges. Experimental results include data on the pellet penetration into the plasma using an advanced pellet tracking diagnostic with improved time and spatial response. Data from the tracker indicates pellet penetrations were between 30 and 86 percent of the plasma minor radius. Line averaged density increases of up to 300 percent were recorded with peak densities of just under 1 times 10^ {21} / m^3, the highest achieved on C-Mod to date. A comparison is made between the ablation source function derived from tracker data with that predicted by four different variations of the neutral shield model

  20. Toward a Social Psychology of Race and Race Relations for the Twenty-First Century.

    Science.gov (United States)

    Richeson, Jennifer A; Sommers, Samuel R

    2016-01-01

    The United States, like many nations, continues to experience rapid growth in its racial minority population and is projected to attain so-called majority-minority status by 2050. Along with these demographic changes, staggering racial disparities persist in health, wealth, and overall well-being. In this article, we review the social psychological literature on race and race relations, beginning with the seemingly simple question: What is race? Drawing on research from different fields, we forward a model of race as dynamic, malleable, and socially constructed, shifting across time, place, perceiver, and target. We then use classic theoretical perspectives on intergroup relations to frame and then consider new questions regarding contemporary racial dynamics. We next consider research on racial diversity, focusing on its effects during interpersonal encounters and for groups. We close by highlighting emerging topics that should top the research agenda for the social psychology of race and race relations in the twenty-first century.

  1. ISLAMIC AND RELIGIOUS STUDIES: Challenges and Opportunities for Twenty-First Century Indonesia

    Directory of Open Access Journals (Sweden)

    Mark Woodward

    2009-06-01

    Full Text Available This paper explores challenges and opportunities for Religious and Islamic Studies in the opening years of the twenty first century. It is especially concerned with relationships between the Indonesian, North American and Global contexts in which the two disciplines are located and the ways in which scholarly discourse can be enriched by trans-national cooperation and discourse. It is argued that Religious Studies should be understood as an academic discourse about religion and must be clearly distinguished from religious discourse internal to and across confessional lines. In a more concrete way, the paper is concerned with the epistemological foundations of the academic study of religion and with the issue of pluralism. It is argued that in today’s globalized world pluralism is a fact that cannot be ignored or eliminated. Discussion on what Eck has identified as three dimensions of pluralism, civic, theolo­gical and academic.

  2. Little Dorrit’s Fourth Volume. Twenty-first Century Remediation of a Victorian Classic

    Directory of Open Access Journals (Sweden)

    Simonetta Falchi

    2014-11-01

    Full Text Available The current interest in the Victorian period is particularly evident in the multitude of successful period dramas and cinema productions deriving their inspiration from Victorian history and culture. Dickens’s Little Dorrit, generated by the difficulties of understanding a ‘new’ world dominated by more and more complicated machines, and markets, is possibly the ideal paradigm to explore this ‘Victorianomania’ because this novel strikes us “no less forcefully today in its indictment of society's ability to destroy through greed and crushing self-interest” (Kirschner 2009.This study carries out a threefold analysis of Little Dorrit's remediation in the twenty-first century: visual remediation – Xue’s 2012 Little Dorrit; audio-visual remediation – the BBC series; and web remediation – fan fiction – in order to investigate Dickens’s appeal and longevity in contemporary media.

  3. Civil Rights Laws as Tools to Advance Health in the Twenty-First Century.

    Science.gov (United States)

    McGowan, Angela K; Lee, Mary M; Meneses, Cristina M; Perkins, Jane; Youdelman, Mara

    2016-01-01

    To improve health in the twenty-first century, to promote both access to and quality of health care services and delivery, and to address significant health disparities, legal and policy approaches, specifically those focused on civil rights, could be used more intentionally and strategically. This review describes how civil rights laws, and their implementation and enforcement, help to encourage health in the United States, and it provides examples for peers around the world. The review uses a broad lens to define health for both classes of individuals and their communities--places where people live, learn, work, and play. Suggestions are offered for improving health and equity broadly, especially within societal groups and marginalized populations. These recommendations include multisectorial approaches that focus on the social determinants of health.

  4. Chemical, Bioactive, and Antioxidant Potential of Twenty Wild Culinary Mushroom Species.

    Science.gov (United States)

    Sharma, S K; Gautam, N

    2015-01-01

    The chemical, bioactive, and antioxidant potential of twenty wild culinary mushroom species being consumed by the people of northern Himalayan regions has been evaluated for the first time in the present study. Nutrients analyzed include protein, crude fat, fibres, carbohydrates, and monosaccharides. Besides, preliminary study on the detection of toxic compounds was done on these species. Bioactive compounds evaluated are fatty acids, amino acids, tocopherol content, carotenoids (β-carotene, lycopene), flavonoids, ascorbic acid, and anthocyanidins. Fruitbodies extract of all the species was tested for different types of antioxidant assays. Although differences were observed in the net values of individual species all the species were found to be rich in protein, and carbohydrates and low in fat. Glucose was found to be the major monosaccharide. Predominance of UFA (65-70%) over SFA (30-35%) was observed in all the species with considerable amounts of other bioactive compounds. All the species showed higher effectiveness for antioxidant capacities.

  5. Niels Bohr and the philosophy of physics twenty-first century perspectives

    CERN Document Server

    Folse, Henry

    2017-01-01

    Niels Bohr and Philosophy of Physics: Twenty-First Century Perspectives examines the philosophical views, influences and legacy of the Nobel Prize physicist and philosophical spokesman of the quantum revolution, Niels Bohr. The sixteen contributions in this collection by some of the best contemporary philosophers and physicists writing on Bohr's philosophy today all carefully distinguish his subtle and unique interpretation of quantum mechanics from views often imputed to him under the banner of the “Copenhagen Interpretation.” With respect to philosophical influences on Bohr's outlook, the contributors analyse prominent similarities between his viewpoint and Kantian ways of thinking, the views of the Danish philosopher Harald Høffding, and themes characteristic of American pragmatism. In recognizing the importance of Bohr's epistemological naturalism they examine his defence of the indispensability of classical concepts from a variety of different perspectives. This collection shows us that Bohr's int...

  6. TWENTY YEARS OF RESEARCH AND SHELLFISH FARMING IN THE MOUTH OF THE KRKA RIVER

    Directory of Open Access Journals (Sweden)

    Drago Maguš

    2001-09-01

    Full Text Available This work shows a short review of activities in the twenty years of research and controlled shellfish farming in the brackish waters of the mouth of the Krka River. Legislative background for granting concessions was especially emphasized as well as problems limiting aquaculture development in this extremely productive area where, according to the latest facts, the production of sea organisms could witness a manifold increase without any substantial disturbance of the ecologic stability of the aquatorium. The analysis of the further farming increase suggests controlled mussel and oyster culturing thus making a polyculture with fish; as well as a secondary culturing of scallops and cockles within the mussel and/or oyster polyculture process in deeper water layers which have not been exploited up to now.

  7. The role of AGG interruptions in fragile X repeat expansions: A twenty year perspective

    Directory of Open Access Journals (Sweden)

    Gary J. Latham

    2014-07-01

    Full Text Available In 1994 it was suggested that AGG interruptions affect the stability of the fragile X triplet repeat. Until recently, however, this hypothesis was not explored on a large scale due primarily to the technical difficulty of determining AGG interruption patterns of the two alleles in females. The recent development of a PCR technology that overcomes this difficulty and accurately identifies the number and position of AGGs has led to several studies that examine their influence on repeat stability. Here we present a historical perspective of relevant studies published during the last twenty years on AGG interruptions and examine those recent publications that have refined risk estimates for repeat instability and full mutation expansions.

  8. Globalisation and Social Imaginaries: The Changing Ideological Landscape of the Twenty-First Century

    Directory of Open Access Journals (Sweden)

    Manfred B. Steger

    2009-01-01

    Full Text Available The proliferation of prefixes like ‘neo’ and ‘post’ that adorn conventional ‘isms’ has cast a long shadow on the contemporary relevance of traditional political belief systems like liberalism, conservatism, and Marxism. This article explores how the thickening of global consciousness finds its expression in the growing capability of today’s political ideologies to translate the rising global imaginary into concrete political programs and agendas. But these subjective dynamics of denationalization at the heart of globalisation have not yet dispensed with the declining national imaginary. The twenty-first century promises to be an ideational interregnum in which both the global and national stimulate people’s deep-seated understandings of community. The essay also offers a rough outline and basic features of a new classification scheme that divides contemporary political ideologies into ‘market globalism’, ‘justice globalism’, and ‘religious globalism’.

  9. Influence of food-environment interactions on health in the twenty-first century.

    Science.gov (United States)

    Fennema, O

    1990-06-01

    The quality and safety of foods are affected by the environment, and the quality and safety of the environment are, in turn, affected by foods and food processing. To explore these interrelationships, as they might exist in the twenty-first century, one must speculate regarding future changes in foods and food processing. Several trends in food processing seem likely to predominate into the twenty-first century, and they will be, for the most part, evolutionary in nature and of low consumer visibility. These trends are greater use of foods marketed in a refrigerated state, greater use of irradiation and combination processes, greater automation and optimization of processes, and greater use of biotechnology. It is also reasonable to assume that food products of the following types will increase in importance, namely, those that are convenient (includes eating away from home), those that are tailored to specific dietary needs, those containing chemically modified components such as altered proteins and carbohydrates, and fabricated foods. If these trends in foods and food processes prevail then concern must be directed to the following areas: Microbiological concerns--refrigerated foods; food service operations; new or altered procedures for processing, handling and storing foods; and new foods or food formulations; attention must be given both to controlling known pathogens as well as newly perceived pathogens. Chemical concerns--toxicants occurring naturally in foods; contaminants; chemicals developing in foods during processing, handling and storage; chemicals used in fabricated foods; and chemicals of newly perceived importance, especially those having adverse, covert effects. Several of these chemical concerns are influenced in seriousness by composition of the food environment.

  10. When Sports Conquered the Republic: A Forgotten Chapter From the «Roaring Twenties

    Directory of Open Access Journals (Sweden)

    Wolfgang Rothe

    1979-08-01

    Full Text Available After the First World War, sport experienced an astonishing growth in the successor states to the two empires of central Europe, a growth which can only be explained sociologically in terms of the general character of the twentieth century as a «physical century.» Furthermore, the intellectual climate of the times as well as the psychic state of the freshly-hatched Republicans plays a special role. That is, the enormous fascination with the «Moloch of sport» can be explained on the one hand by a non-intellectual worshipping of purely physical, measurable maximum achievements (record-mania, on the other by the America-cult that arose during this period (identical with the positive myth of technology, the cult of machines that replaced the pre-war view. A third factor was the cult of heroes, the need to worship «great men» that was not extinguished in 1918 and which had only sought new objects. The top sportsman was one of these new objects of identification. In astonishing (and hard to explain contradiction to the exorbitant value placed on sport in the life of the twenties, the number of distinctive literary works on sport is relatively small—much smaller than in the post-1945 period. These reflect the prevailing enthusiasm for sport, sometimes naively and positively, sometimes negatively and ironically. An expansion of the sport theme into a true philosophy of life occurs in the only sport-novel of the twenties, Kasimir Edschmid's Sport um Gagaly , which to some degree continues the traditional German Bildungsroman , but does so in a hopelessly elitist and snobbish way.

  11. Perceptions of eating disorder diagnoses and body image issues in four male cases in Singapore

    OpenAIRE

    Boon, Evelyn; Zainal, Kelly Ann; Touyz, Stephen W.

    2017-01-01

    Background Despite the increasing number of patients presenting for treatment, little is still known about male eating disorders cases. The current study presents four male eating disorder cases presented to our specialized treatment facility in Singapore. Case presentation Cases 1, 2 and 3 are homosexual males in their twenties and thirties who presented with anorexia nervosa and bulimia nervosa. Case 4 is a heterosexual male in his twenties diagnosed with binge eating disorder. All four cas...

  12. Black Hats and White Hats: The Effect of Organizational Culture and Institutional Identity on the Twenty-third Air Force

    National Research Council Canada - National Science Library

    Koskinas, Ioannis

    2006-01-01

    .... Although brief, the Twenty-third Air Force's experience provides sufficient data for a thorough analysis of the effect of organizational culture and institutional agendas on the evolution of a nascent organization...

  13. Twenty-four-hour esophageal pH monitoring in children and adolescents with chronic and/or recurrent rhinosinusitis

    Directory of Open Access Journals (Sweden)

    V.R.S.G. Monteiro

    2005-02-01

    Full Text Available Gastroesophageal reflux (GER disorder was studied in children and adolescents with chronic and/or recurrent rhinosinusitis not associated with bronchial asthma. Ten children with a clinical and radiological diagnosis of chronic and/or recurrent rhinosinusitis, consecutively attended at the Pediatric Otolaryngology Outpatient Clinic, Federal University of São Paulo, were evaluated. Prolonged esophageal pH monitoring was used to investigate GER disorder. The mean age of the ten patients evaluated (eight males was 7.4 ± 2.4 years. Two patients presented vomiting as a clinical manifestation and one patient presented retrosternal pain with a burning sensation. Twenty-four-hour esophageal pH monitoring was performed using the Sandhill apparatus. An antimony probe electrode was placed in the lower third of the esophagus, confirmed by fluoroscopy and later by a chest X-ray. The parameters analyzed by esophageal pH monitoring included: total percent time of the presence of acid esophageal pH, i.e., pH below 4 (<4.2%; total number of acid episodes (<50 episodes; number of reflux episodes longer than 5 min (3 or less, and duration of the longest reflux episode (<9.2 min. One patient (1/10, 10% presented a 24-h esophageal pH profile compatible with GER disorder. This data suggest that an association between chronic rhinosinusitis not associated with bronchial asthma and GER disorder may exist in children and adolescents, especially in those with compatible GER disorder symptoms. In these cases, 24-h esophageal pH monitoring should be performed before indicating surgery, since the present data suggest that 10% of chronic rhinosinusitis surgeries can be eliminated.

  14. Twenty-Five Years of the Fuzzy Factor: Fuzzy Logic, the Courts, and Student Press Law.

    Science.gov (United States)

    Plopper, Bruce L.; McCool, Lauralee

    A study applied the structure of fuzzy logic, a fairly modern development in mathematical set theory, to judicial opinions concerning non-university, public school student publications, from 1975 to 1999. The study examined case outcomes (19 cases generated 27 opinions) as a function of fuzzy logic, and it evaluated interactions between fuzzy…

  15. Case Study Report #16. Marydel Green.

    Science.gov (United States)

    Myers, Douglas D.; And Others

    This document presents one in a series of twenty-three case studies derived from in-depth interviews using a sampling of former participants in the Mountain-Plains program, a residential, family-based education program developed to improve the economic potential and lifestyle of selected student families in a six-state area. Each case study…

  16. A Case Study of "Empathetic Teaching Artistry"

    Science.gov (United States)

    Risner, Doug

    2014-01-01

    This case study is one of twenty cases derived from Anderson and Risner's international study of teaching artists in dance, and theatre, which investigated participants' (n=172) artistic and academic preparation in dance, and theatre, initial entry into the teaching artist field, rewards, challenges, and obstacles in participants' work, artists'…

  17. What are the intensities and line-shapes of the twenty four polarization terms in coherent anti-Stokes Raman spectroscopy?

    Science.gov (United States)

    Niu, Kai; Lee, Soo-Y.

    2015-12-01

    Coherent anti-Stokes Raman spectroscopy (CARS) is conventionally described by just one diagram/term where the three electric field interactions act on the ket side in a Feynman dual time-line diagram in a specific time order of pump, Stokes and probe pulses. In theory, however, any third-order nonlinear spectroscopy with three different electric fields interacting with a molecule can be described by forty eight diagrams/terms. They reduce to just 24 diagrams/terms if we treat the time ordering of the electric field interactions on the ket independently of those on the bra, i.e. the ket and bra wave packets evolve independently. The twenty four polarization terms can be calculated in the multidimensional, separable harmonic oscillator model to obtain the intensities and line-shapes. It is shown that in fs/ps CARS, for the two cases of off-resonance CARS in toluene and resonance CARS in rhodamine 6G, where we use a fs pump pulse, a fs Stokes pulse and a ps probe pulse, we obtain sharp vibrational lines in four of the polarization terms where the pump and Stokes pulses can create a vibrational coherence on the ground electronic state, while the spectral line-shapes of the other twenty terms are broad and featureless. The conventional CARS term with sharp vibrational lines is the dominant term, with intensity at least one order of magnitude larger than the other terms.

  18. What are the intensities and line-shapes of the twenty four polarization terms in coherent anti-Stokes Raman spectroscopy?

    Energy Technology Data Exchange (ETDEWEB)

    Niu, Kai [School of Science, Tianjin University of Technology and Education, Tianjin, 300222 (China); Lee, Soo-Y., E-mail: sooying@ntu.edu.sg [Division of Physics & Applied Physics, and Division of Chemistry & Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore 637371 (Singapore)

    2015-12-15

    Coherent anti-Stokes Raman spectroscopy (CARS) is conventionally described by just one diagram/term where the three electric field interactions act on the ket side in a Feynman dual time-line diagram in a specific time order of pump, Stokes and probe pulses. In theory, however, any third-order nonlinear spectroscopy with three different electric fields interacting with a molecule can be described by forty eight diagrams/terms. They reduce to just 24 diagrams/terms if we treat the time ordering of the electric field interactions on the ket independently of those on the bra, i.e. the ket and bra wave packets evolve independently. The twenty four polarization terms can be calculated in the multidimensional, separable harmonic oscillator model to obtain the intensities and line-shapes. It is shown that in fs/ps CARS, for the two cases of off-resonance CARS in toluene and resonance CARS in rhodamine 6G, where we use a fs pump pulse, a fs Stokes pulse and a ps probe pulse, we obtain sharp vibrational lines in four of the polarization terms where the pump and Stokes pulses can create a vibrational coherence on the ground electronic state, while the spectral line-shapes of the other twenty terms are broad and featureless. The conventional CARS term with sharp vibrational lines is the dominant term, with intensity at least one order of magnitude larger than the other terms.

  19. What are the intensities and line-shapes of the twenty four polarization terms in coherent anti-Stokes Raman spectroscopy?

    Directory of Open Access Journals (Sweden)

    Kai Niu

    2015-12-01

    Full Text Available Coherent anti-Stokes Raman spectroscopy (CARS is conventionally described by just one diagram/term where the three electric field interactions act on the ket side in a Feynman dual time-line diagram in a specific time order of pump, Stokes and probe pulses. In theory, however, any third-order nonlinear spectroscopy with three different electric fields interacting with a molecule can be described by forty eight diagrams/terms. They reduce to just 24 diagrams/terms if we treat the time ordering of the electric field interactions on the ket independently of those on the bra, i.e. the ket and bra wave packets evolve independently. The twenty four polarization terms can be calculated in the multidimensional, separable harmonic oscillator model to obtain the intensities and line-shapes. It is shown that in fs/ps CARS, for the two cases of off-resonance CARS in toluene and resonance CARS in rhodamine 6G, where we use a fs pump pulse, a fs Stokes pulse and a ps probe pulse, we obtain sharp vibrational lines in four of the polarization terms where the pump and Stokes pulses can create a vibrational coherence on the ground electronic state, while the spectral line-shapes of the other twenty terms are broad and featureless. The conventional CARS term with sharp vibrational lines is the dominant term, with intensity at least one order of magnitude larger than the other terms.

  20. Twenty-First Century Spectroscopic Data for Determinations of Interstellar Ice Abundances

    Science.gov (United States)

    Hudson, Reggie

    The molecular chemistry of interstellar and circumstellar environments consists of a complex interplay between gas- and solid-phase processes. An important step in unraveling this chemistry has been the observation and identification of gas-phase molecules, mainly by radio and microwave observations. Nearly 200 interstellar and circumstellar gas-phase molecules are known, but only about 10 identifications, mostly from infrared (IR) studies, have been made of solid-phase species, usually termed “ices”. Determining the abundances of icy molecules has been a continual challenge due to the lack of appropriate laboratory measurements of spectral band strengths, optical constants, refractive indices, and ice densities. Our research group is now engaged in two new laboratory programs for just such measurements. In one program we measure IR optical constants (n and k) for molecules found in molecular ices. Our second new laboratory program focuses on densities and refractive indices, which are required for generating optical constants and spectral band strengths from laboratory IR data. This combination of research efforts within a single facility provides an unusual, if not unique, opportunity for producing the lab data required for more-accurate analysis and interpretation of Spitzer, and other, observations of interstellar ices. In spite of a general belief that such lab results may already be available, a careful literature search quickly reveals significant, surprising, and stunning gaps and deficiencies. The current situation is paradoxical in that twenty-first century spectra of astronomical ices near 10 K are being analyzed for molecular abundances using room-temperature physical properties and results from vacuum-tube dispersive spectrometers and mechanical planimeters. Here we propose a systematic effort to bring the lab data into the twenty-first century through the measurement of IR spectra and optical constants, refractive indices, and densities of several

  1. Metastatic primary adenocarcinoma of the bladder in a twenty-five years old woman

    Directory of Open Access Journals (Sweden)

    Massimo Valerio

    2011-02-01

    Full Text Available Primary adenocarcinoma of the bladder is a rare tumor. The classification between primary vesical and urachal is debated. We present the case of a young female who presented clinicopathological features of a metastatic urachal adenocarcinoma, but the histological result revealed primary adenocarcinoma of the bladder contrary to expectancy. To the best of our knowledge this is the first reported case of a metastatic adenocarcinoma of the bladder in a 25 years old female. This case emphasizes the challenge for urologists to recognize and manage this aggressive tumor in the setting described.

  2. History and evolution of surgical ethics: John Gregory to the twenty-first century.

    Science.gov (United States)

    Namm, Jukes P; Siegler, Mark; Brander, Caroline; Kim, Tae Yeon; Lowe, Christian; Angelos, Peter

    2014-07-01

    As surgery grew to become a respected medical profession in the eighteenth century, medical ethics emerged as a response to the growing need to protect patients and maintain the public's trust in physicians. The early influences of John Gregory and Thomas Percival were instrumental in the formulation of patient-centered medical ethics. In the late nineteenth century, the modern surgical advances of anesthesia and antisepsis created the need for a discipline of ethics specific to surgery in order to confront new and evolving ethical issues. One of the founding initiatives of the American College of Surgeons in 1913 was to eliminate unethical practices such as fee-splitting and itinerant surgery. As surgery continued to advance in the era of solid organ transplantation and minimally invasive surgery in the latter half of the twentieth century, surgical innovation and conflict of interest have emerged as important ethical issues moving forward into the twenty-first century. Surgical ethics has evolved into a distinct branch of medical ethics, and the core of surgical ethics is the surgeon-patient relationship and the surgeon's responsibility to advance and protect the well-being of the patient.

  3. Halychyna. Journal of Regional Studies: Science, Culture, and Education. Twenty Years of Publishing Activity

    Directory of Open Access Journals (Sweden)

    Mykola Kuhutiak

    2017-10-01

    Full Text Available This is a review of the twenty-year-long publishing activity of Halychyna. Journal of Regional Studies: Science, Culture and Education, one of the first Ukrainian journals for historians, philologists, art critics that appeared in the independent Ukraine. In Halychyna, there has been published the works by well-known scholars of Vasyl Stefanyk Precarpathian National University and many other higher educational establishments of Ukraine. The Journal can boast an array of sections – archaeology, history, ethnology, political science, historiography, source studies, documents and materials, culturology, art criticism, historical biography studies, and others. Most of the studies published in Halychyna focus on the issues of the modern and contemporary history of Ukraine, ethnology. A special attention is given to the issues of the Ukrainian national liberation movement in the 20th century, the Ukrainian national revival in the 19th–20th century, the activity of the political parties in Galicia in the late 19th–early 20th century, source studies and historiography in Ukraine, historical regional studies, the problems of modern state formation in Ukraine, and others.

  4. Waving or Drowning? Perceptions of Second Wave Feminism Through a Twenty-First Century Lens

    OpenAIRE

    Bralesford, Helen Margaret

    2006-01-01

    This dissertation sets out to explore some twenty-first century perceptions of second wave feminism with as little mediation from the academy as possible by employing the lens of popular culture to tease out and examine some of the assumptions about the second wave that have become culturally embedded at a grass roots level. The first chapter takes Betty Friedan���������������¢��������������������������������s seminal text The Feminine Mysti...

  5. Twenty-five astronomical observations that changed the world and how to make them yourself

    CERN Document Server

    Marett-Crosby, Michael

    2013-01-01

    Human history is also the record of our fascination with the sky, and to look upwards is to follow in the steps of such greats as Galileo and Newton. What they and others once saw in the heavens for the first time, amateur astronomers can discover anew using this guide to twenty-five of the greatest journeys through space.   Starting with our most visible companion the Moon, each chapter offers a step-by-step walk-through of famous astronomical observations from the history of science. Beginning with the easiest targets, sometimes even accessible with the naked eye, the challenges become progressively more difficult. Beginner astronomers and more experienced hobbyists alike can reacquaint themselves with the wonders of our fellow planets and even reach far beyond our own solar system to touch on such incredible phenomena as the birth of new stars in nebula systems and the deceptive nothingness of black holes. The would-be astronaut can spy the International Space Station in orbit with binoculars or the dooms...

  6. Twenty Years of Ablative Photodecomposition (Industrial Applications of Physics Prize Lecture)

    Science.gov (United States)

    Srinivasan, Rangaswamy

    2004-03-01

    It was a little over twenty years ago that two groups, one in the U.S. and another in Hull, U.K. working independently, reported that ultraviolet laser pulses of nanosecond duration were capable of etching organic polymer films without any need for further development.In 1982, our group at the IBM Research Center which studied this phenomenon at 193nm named the process "Ablative Photodecomposition". Dyer and his group in Hull reported similar results at 248nm and 308nm in 1983. We also showed that the process worked well in the etching of tissue and had the potential to be of use in surgery since there was no detectable heat damage around the exposed area. These reports led to a burst of activity from numerous groups all over the world which has not slowed down significantly to the present day. The driving force behind the activity was and continues to be the potential for applications in several areas of computer hardware technology as well as in corneal refractive surgery. Today these applications can be said to be firmly in place and well-accepted. Strangely, the science behind the process is still a subject for serious discussion. The reason for this is the mix of physicists, chemists, medical doctors and engineers who have stepped into the debate. The result is a true 'Babel' which will be pointed out.

  7. The twenty-year war over England's National Health Service: a report from the battlefield.

    Science.gov (United States)

    Klein, Rudolf

    2013-08-01

    This article analyzes the latest battle in the twenty-year war to change England's National Health Service (NHS), starting with the internal market reforms introduced by the Thatcher government and now carried one step farther by David Cameron's coalition government. The government's program of change is characterized by (1) its wide scope and the organizational upheavals involved and (2) the fact that it is being introduced at a time when the NHS faces unprecedented fiscal pressures. The legislation faced strong political, public, and professional hostility both from those who saw it as a crime against the founding principles of the NHS and from those who saw it as a disruptive blunder that created more problems than it solved. This article asks three questions. Why did the coalition government embark on a policy course guaranteed to lose it votes? How will the much-amended legislation work out in practice: what are the risks and uncertainties? What will be the program's impact: will it, like previous waves of change, disappoint both the prophets of doom and the visionaries of transformation? The conclusion drawn is that the essential, defining characteristics of the NHS are not under threat. It continues to be a publicly funded service, freely available to all. It is not being privatized. But it is moving toward the kind of pluralistic system that would have been established by Britain's last, wartime coalition government, had not Aneurin Bevan nationalized the hospital service in 1948.

  8. Twenty Years After the 1988 Yellowstone Fires: Lessons About Disturbance and Ecosystems

    Science.gov (United States)

    Romme, W.H.; Boyce, M.S.; Gresswell, R.; Merrill, E.H.; Minshall, G.W.; Whitlock, C.; Turner, M.G.

    2011-01-01

    The 1988 Yellowstone fires were among the first in what has proven to be an upsurge in large severe fires in the western USA during the past 20 years. At the time of the fires, little was known about the impacts of such a large severe disturbance because scientists had had few previous opportunities to study such an event. Ecologists predicted short- and long-term effects of the 1988 fires on vegetation, biogeochemistry, primary productivity, wildlife, and aquatic ecosystems based on scientific understanding of the time. Twenty-plus years of subsequent study allow these early predictions to be evaluated. Most of the original predictions were at least partially supported, but some predictions were refuted, others nuanced, and a few postfire phenomena were entirely unexpected. Post-1988 Yellowstone studies catalyzed advances in ecology focused on the importance of spatial and temporal heterogeneity, contingent influences, and multiple interacting drivers. Post-1988 research in Yellowstone also has changed public perceptions of fire as an ecological process and attitudes towards fire management. Looking ahead to projected climate change and more frequent large fires, the well-documented ecological responses to the 1988 Yellowstone fires provide a foundation for detecting and evaluating potential changes in fire regimes of temperate mountainous regions. ?? 2011 Springer Science+Business Media, LLC.

  9. In vitro conservation of twenty-three overexploited medicinal plants belonging to the Indian sub continent.

    Science.gov (United States)

    Verma, Priyanka; Mathur, Ajay Kumar; Jain, Sheetal Prasad; Mathur, Archana

    2012-01-01

    Twenty-three pharmaceutically important plants, namely, Elaeocarpus spharicus, Rheum emodi, Indigofera tinctoria, Picrorrhiza kurroa, Bergenia ciliata, Lavandula officinalis, Valeriana wallichii, Coleus forskohlii, Gentiana kurroo, Saussurea lappa, Stevia rebaudiana, Acorus calamus, Pyrethrum cinerariaefolium, Aloe vera, Bacopa monnieri, Salvia sclarea, Glycyrrhiza glabra, Swertia cordata, Psoralea corylifolia, Jurinea mollis, Ocimum sanctum, Paris polyphylla, and Papaver somniferum, which are at the verge of being endangered due to their overexploitation and collection from the wild, were successfully established in vitro. Collections were made from the different biodiversity zones of India including Western Himalaya, Northeast Himalaya, Gangetic plain, Western Ghats, Semiarid Zone, and Central Highlands. Aseptic cultures were raised at the morphogenic level of callus, suspension, axillary shoot, multiple shoot, and rooted plants. Synseeds were also produced from highly proliferating shoot cultures of Bacopa monnieri, Glycyrrhiza glabra, Stevia rebaudiana, Valeriana wallichii, Gentiana kurroo, Lavandula officinalis, and Papaver somniferum. In vitro flowering was observed in Papaver somniferum, Psoralea corylifolia, and Ocimum sanctum shoots cultures. Out of 23 plants, 18 plants were successfully hardened under glasshouse conditions.

  10. In Vitro Conservation of Twenty-Three Overexploited Medicinal Plants Belonging to the Indian Sub Continent

    Directory of Open Access Journals (Sweden)

    Priyanka Verma

    2012-01-01

    Full Text Available Twenty-three pharmaceutically important plants, namely, Elaeocarpus spharicus, Rheum emodi, Indigofera tinctoria, Picrorrhiza kurroa, Bergenia ciliata, Lavandula officinalis, Valeriana wallichii, Coleus forskohlii, Gentiana kurroo, Saussurea lappa, Stevia rebaudiana, Acorus calamus, Pyrethrum cinerariaefolium, Aloe vera, Bacopa monnieri, Salvia sclarea, Glycyrrhiza glabra, Swertia cordata, Psoralea corylifolia, Jurinea mollis, Ocimum sanctum, Paris polyphylla, and Papaver somniferum, which are at the verge of being endangered due to their overexploitation and collection from the wild, were successfully established in vitro. Collections were made from the different biodiversity zones of India including Western Himalaya, Northeast Himalaya, Gangetic plain, Western Ghats, Semiarid Zone, and Central Highlands. Aseptic cultures were raised at the morphogenic level of callus, suspension, axillary shoot, multiple shoot, and rooted plants. Synseeds were also produced from highly proliferating shoot cultures of Bacopa monnieri, Glycyrrhiza glabra, Stevia rebaudiana, Valeriana wallichii, Gentiana kurroo, Lavandula officinalis, and Papaver somniferum. In vitro flowering was observed in Papaver somniferum, Psoralea corylifolia, and Ocimum sanctum shoots cultures. Out of 23 plants, 18 plants were successfully hardened under glasshouse conditions.

  11. Twenty Years of National Minority Protection in the Republic of Croatia

    Directory of Open Access Journals (Sweden)

    Siniša Tatalović

    2011-12-01

    Full Text Available The paper contains a review of policies towards national minorities in the Republic of Croatia in the past twenty years, with reference to the perspective of minority rights implementation. The topic has been analysed in relation to two independent variables – the influence of external factors, i.e. the international community, and internal political processes that have had influence on the realisation of national minority rights. Today, as a country and society on the eve of accession to the European Union, along with a legislatively developed and institutionally branched model of the implementation of national minority rights, we can not claim to have established permanent protection of their rights. The degree of national minority integration in society is the only true indicator of policy success in relation to national minorities. The goal of this policy ought to be complete integration of national minorities into public, cultural, economic and political life, but accompanied by the preservation of their cultural and national identity. The Croatian model has been set up in such a way, but the manner in which it functions will depend on the political will to implement it, the willingness of national minority members to be active subjects of social and political life, as well as on civil society and Croatian society as a whole.

  12. DEVELOPMENT OF THE INFORMATION COMPETENCE OF THE ACADEMIC COMMUNITY: TWENTY YEARS AFTER

    Directory of Open Access Journals (Sweden)

    Glosiene, Audrone

    2006-12-01

    Full Text Available Twenty years ago, reading culture, library skills’ development used to be one of the core directions in research and teaching policy of the Department of Library Science at Vilnius University. Lateron, the topic was marginalized and today we return to the field that meanwhile has developed huge knowledge and experience base worldwide. A stimulus for the return was participation in BIBLIONOVA project. The aim of the article is to present a holistic approach towards information competency development in a modern academic institution. Prescriptive approach based on information literacy standards proved to be limited and not always effective in the academic environment.Information competency development is problem-specific, domain-specific, and disciplinespecific. It is interrelated with critical thinking, analytical skills as well as creativity and computerliteracy skills. Holistically, information competency development is an integral part of university’s life-long learning strategy. Critical success factors for information competency development areopen and problem-based learning and cooperative, inclusive strategies of the whole university. Academic libraries continue to play a major role in the process but the connections with faculty and administration in the process are of major importance.

  13. Between vanguard and exclusion- young people of the twenty-first century

    Directory of Open Access Journals (Sweden)

    Agnieszka Gil

    2011-12-01

    Full Text Available This study has been narrowed down to reveal a paradox. Here the vanguard of culture and civilization - which is regarded as young people of the twenty-first century – is embroiled in a discourse of exclusion: economic, political and cultural life. In secondary school programs and high schools we do not find specific references and studies, primarily based on the needs of students, about the theory of popular culture and cultural education in the area of pop culture. The paradox of exclusion of mainstream culture from educational discourse is schizophrenic. The political exclusion of young people of the XXI century I consider all the disparaging scientific discourse, which skips the actual media and communication competence of young people. Prosumers, cognitarchy, digital natives, C-generation – they are for the modern economy “Silicon Valley” - their market power to exclude is already unstoppable. In other areas it remains to be considered whether excluding young people from the cultural discourse will not deprive our future teachers and translators of the next civilization revolution of social reality...

  14. The Twenty-five Maiden Ladies’ Tomb and Predicaments of the Feminist Movement in Taiwan

    Directory of Open Access Journals (Sweden)

    Anru Lee

    2010-01-01

    Full Text Available “The Twenty-five Maiden Ladies’ Tomb” is the collective burial site of the female workers who died in a ferry accident on their way to work in 1973. The fact that of the more than 70 passengers on board all 25 who died were unmarried young women, and the taboo in Taiwanese culture that shuns unmarried female ghosts, made the Tomb a fearsome place. Feminists in Gaoxiong (高雄 had for some years wanted the city government to change the tomb’s public image. Their calls were not answered until the Gaoxiong mayor’s office finally allocated money to clean up the gravesite and, as part of the city’s plans to develop urban tourism, to remake it into the tourist-friendly “Memorial Park for Women Labourers”. Consequently, even though the tomb renovation seemed to indicate a triumph of the feminist endeavour, it was more a result of the Gaoxiong city government’s efforts towards culture-led urban revitalization.

  15. The advance of technology as a prelude to the laboratory of the twenty-first century.

    Science.gov (United States)

    Woo, J; Henry, J B

    1994-09-01

    Technological changes in the clinical laboratory are usually driven by the goal of patient care optimization. In the last decade, the trend appeared to be directed at clinical laboratory decentralization. A new generation of analytical instruments, the biosensors, is redirecting laboratory testing closer to the patient, at the bedside, in the physician's office, and by the patient at home. These miniaturized biosensors are easy to operate, require small specimen size, and provide reliable results with rapid TAT. Thus far, bedside testing using biosensor technology appears to offer unique opportunities for earlier availability of clinical laboratory data, decision making, and more specific diagnosis, and faster and more frequent monitoring; these may translate into improved patient care and reduced hospital costs. It is likely that this trend will continue into the twenty-first century. Electrochemical sensors (e.g., for electrolytes, glucose, urea, and hematocrit) and pulse oximetry, having gained clinical acceptance, will probably be the leading instrumentation for bedside testing. Continuous monitoring either by near-infrared sensing technology or with an implantable sensor is valuable in the care of the critically ill patient. Acceptance for clinical use will depend on complete data integration and a favorable cost-benefit ratio.

  16. Molecular characterization of twenty polymorphic microsatellite markers in the polyploid fruit tree species Syzygium samarangense (Myrtaceae).

    Science.gov (United States)

    Lai, J M; Tsai, C C; Yen, C R; Ko, Y Z; Chen, S R; Weng, I S; Lin, Y S; Chiang, Y C

    2015-10-21

    Syzygium samarangense (Blume) Merr. & Perry (wax apple) is an important commercial fruit tree in Southeast Asia. Here, microsatellite markers were developed to evaluate genetic diversity and distinguish cultivars in this species. In total, 161 microsatellite loci with sufficient flanking sequences to design primer sets were isolated from wax apple using a magnetic bead-enrichment method. Fifty-eight primer sets were designed based on the flanking sequences of each single sequence repeat (SSR) locus and were tested using 14 wax apple cultivars/lines. Twenty SSR loci were found to be polymorphic and transferable across the 14 wax apple cultivars/lines. The number of alleles and effective number of alleles detected per locus ranged from 4 to 12 and from 1.697 to 9.800, respectively. The expected heterozygosity ranged from 0.150 to 0.595 (mean = 0.414). Polymorphism information content values ranged from 0.502 to 0.866 (mean = 0.763). These new microsatellite loci will be of value for characterization of genetic diversity in wax apples and for the identification of cultivars.

  17. Emerging Tick-Borne Viruses in the Twenty-First Century

    Directory of Open Access Journals (Sweden)

    Karen L. Mansfield

    2017-07-01

    Full Text Available Ticks, as a group, are second only to mosquitoes as vectors of pathogens to humans and are the primary vector for pathogens of livestock, companion animals, and wildlife. The role of ticks in the transmission of viruses has been known for over 100 years and yet new pathogenic viruses are still being detected and known viruses are continually spreading to new geographic locations. Partly as a result of their novelty, tick-virus interactions are at an early stage in understanding. For some viruses, even the principal tick-vector is not known. It is likely that tick-borne viruses will continue to emerge and challenge public and veterinary health long into the twenty-first century. However, studies focusing on tick saliva, a critical component of tick feeding, virus transmission, and a target for control of ticks and tick-borne diseases, point toward solutions to emerging viruses. The aim of this review is to describe some currently emerging tick-borne diseases, their causative viruses, and to discuss research on virus-tick interactions. Through focus on this area, future protein targets for intervention and vaccine development may be identified.

  18. Phenotypic Responses of Twenty Diverse Proso Millet (Panicum miliaceum L. Accessions to Irrigation

    Directory of Open Access Journals (Sweden)

    Cedric Habiyaremye

    2017-03-01

    Full Text Available To date, little research has been conducted on the phenotypic responses of proso millet to drought and deficit irrigation treatments in the dryland wheat-based cropping systems of the Palouse bioregion of the U.S. The objectives of this study were to evaluate critical agronomic traits of proso millet, including emergence, plant height, days to heading, days to maturity, and grain yield, with and without supplemental irrigation. Twenty diverse proso millet accessions, originating from Bulgaria, Czechoslovakia, Morocco, the former Soviet Union, Turkey, and the United States, were grown in irrigated and non-irrigated treatments under organic conditions in Pullman, WA, from 2012 to 2014. Irrigation was shown to significantly improve emergence and increase plant height at stem extension and to hasten ripening of all the varieties, whereas heading date was not affected by irrigation in two of the three years tested. Irrigation resulted in higher mean seed yield across all varieties, with ‘GR 665’ and ‘Earlybird’ performing best under irrigation. Seed yield was highest in ‘GR 658’ and ‘Minsum’ in the non-irrigated treatment, suggesting the importance of identification and utilization of varieties adapted to low rainfall conditions. The highest yielding varieties in irrigated systems are unlikely be the highest yielding in dryland systems. Our results suggest that millet has potential as a regionally novel crop for inclusion in traditional dryland cropping rotations in the Palouse ecosystem, thereby contributing to increased cropping system diversity.

  19. Twenty-year trends in the prevalence of Down syndrome and other trisomies in Europe

    DEFF Research Database (Denmark)

    Loane, Maria; Morris, Joan K; Addor, Marie-Claude

    2013-01-01

    This study examines trends and geographical differences in total and live birth prevalence of trisomies 21, 18 and 13 with regard to increasing maternal age and prenatal diagnosis in Europe. Twenty-one population-based EUROCAT registries covering 6.1 million births between 1990 and 2009...... screening-related differences in total prevalence. Poisson regression was used. The proportion of births in the population to mothers aged 35+ years in the participating registries increased from 13% in 1990 to 19% in 2009. Total prevalence per 10 000 births was 22.0 (95% CI 21.7-22.4) for trisomy 21, 5.......0 (95% CI 4.8-5.1) for trisomy 18 and 2.0 (95% CI 1.9-2.2) for trisomy 13; live birth prevalence was 11.2 (95% CI 10.9-11.5) for trisomy 21, 1.04 (95% CI 0.96-1.12) for trisomy 18 and 0.48 (95% CI 0.43-0.54) for trisomy 13. There was an increase in total and total corrected prevalence of all three...

  20. The Russian economy twenty years after the end of the socialist economic system

    Directory of Open Access Journals (Sweden)

    Julian Cooper

    2013-01-01

    Full Text Available It is now more than twenty years since the collapse of the Soviet Union and the beginning of transition to a market economy. The non-market, ‘planned’ economic system of the old order had its own specific mode of functioning, which over time had a profound impact on the structure of the economy. The article explores the extent to which the far-reaching economic transformation undertaken in post-communist Russia since the end of 1991 has overcome the legacies of the Soviet system. Has the socialist economic order that existed for over sixty years disappeared entirely, or are there still survivals and legacies that shape and influence, at least in part, the present-day Russian economy? These issues are examined by focussing on one particular sector that played a dominant role in the USSR, namely the defence industry and the military economy more generally. It is concluded that there are indeed significant survivals and legacies of the socialist past: market transformation is still incomplete.

  1. Health of Europeans twenty years after the fall of Berlin wall.

    Science.gov (United States)

    Ginter, E; Simko, V

    2010-01-01

    The failure of central planning in the totalitarian systems of the USSR and its satellites adversely affected not only the economy and social relations but also the population health. While in the countries with established democracy (DEM) the general health and the life expectancy (LE) steadily improved, in countries declaring socialism (SOC) the LE was stagnant and in the USSR even decreased. Dramatic changes in Russia after the demise of Soviet Union resulted in an extraordinary destabilization of LE that reached a minimum in 1994. Remarkably, even twenty years after the breakdown of the Iron Curtain there persists a gap in the general health between the DEM and the SOC regions of Europe. Within the territory of the former Soviet influence there are additional differences in LE: Central Europe is much better off than Russia and its neighbours. Main cause of relatively high mortality in the post totalitarian Europe is the cardiovascular disease (CVD). Among females about 80% difference in LE between DEM and SOC countries is related to premature CVD mortality. In SOC males compared to DEM, about 50% of the higher mortality is caused by CVD, 20% is related to external factors (trauma, suicide) and 10% is oncologic disorders. The main suggested cause of such excess mortality, besides a low socioeconomic level and limited funding for health care, is an improper life style: alcoholism, smoking and inadequate intake of protective nutrients. Alcoholism, especially binge drinking is a prominent factor in Russia, Belarus, Ukraine and in the Baltic Republics (Fig. 6, Tab. 4, Ref. 20).

  2. Civil engineering at the crossroads in the twenty-first century.

    Science.gov (United States)

    Ramírez, Francisco; Seco, Andres

    2012-12-01

    The twenty-first century presents a major challenge for civil engineering. The magnitude and future importance of some of the problems perceived by society are directly related to the field of the civil engineer, implying an inescapable burden of responsibility for a group whose technical soundness, rational approach and efficiency is highly valued and respected by the citizen. However, the substantial changes in society and in the way it perceives the problems that it considers important call for a thorough review of our structures, both professional and educational; so that our profession, with its undeniable historical prestige, may modernize certain approaches and attitudes in order to continue to be a reliable instrument in the service of society, giving priority from an ethical standpoint to its actions in pursuit of "the public good". It possesses important tools to facilitate this work (new technologies, the development of communications, the transmission of scientific thought.···); but there is nevertheless a need for deep reflection on the very essence of civil engineering: what we want it to be in the future, and the ability and willingness to take the lead at a time when society needs disinterested messages, technically supported, reasonably presented and dispassionately transmitted.

  3. An empirical examination of consumer effects across twenty degrees of latitude.

    Science.gov (United States)

    Lavender, James T; Dafforn, Katherine A; Bishop, Melanie J; Johnston, Emma L

    2017-09-01

    The strength and importance of consumer effects are predicted to increase toward low latitudes, but this hypothesis has rarely been tested using a spatially consistent methodology. In a consumer-exclusion experiment spanning twenty degrees of latitude along the east Australian coast, the magnitude of consumer effects on sub-tidal sessile assemblage composition was not greater at low than high latitudes. Across caged and control assemblages, Shannon's diversity, Pielou's evenness, and richness of functional groups decreased with increasing latitude, but the magnitude of consumer effects on these metrics did not display consistent latitudinal gradients. Instead, latitudinal gradients in consumer effects were apparent for individual functional groups. Solitary ascidians displayed the pattern consistent with predictions of greater direct effects of predators at low than high latitude. As consumers reduced the biomass of this and other competitive dominants, groups less prone to predation (e.g., hydroids, various groups of bryozoans) were able to take advantage of freed space in the presence of consumers and show increased abundances there. This large-scale empirical study demonstrates the complexity of species interactions, and the failure of assemblage-level metrics to adequately capture consumer effects over large spatial gradients. © 2017 by the Ecological Society of America.

  4. Simultaneous quantification of twenty Amadori products in soy sauce using liquid chromatography-tandem mass spectrometry.

    Science.gov (United States)

    Katayama, Hiroshi; Tatemichi, Yuki; Nakajima, Ayako

    2017-08-01

    A liquid chromatography-tandem mass spectrometry method using a pentafluorophenylpropyl-bonded silica column was developed to simultaneously quantify twenty Amadori products (APs), including N-(1-Deoxy-d-fructosyl-1-yl)-l-isoleucine (Fru-Ile) and N-(1-Deoxy-d-fructosyl-1-yl)-l-leucine (Fru-Leu), in soy sauce, without the need for an ion-pairing reagent or sample derivatization. The method was applied to six types of soy sauce, to determine the total AP levels and the levels of individual APs. The level of total APs widely varied between the eight samples, from 358mg/L to 24347mg/L. The concentrations of N-ε-(1-deoxy-d-fructosyl-1-yl)-l-lysine (Fru-Lys) and N-(1-deoxy-d-fructosyl-1-yl)-l-pyroglutamic acid (Fru-pGlu) were the highest among the APs and the level of Fru-pGlu was similar to that of Fru-Lys. Furthermore, fermentation periods of up to six months greatly influenced AP levels in soy sauce but the levels remained constant thereafter. Thermal treatment of soy sauce had little effect on AP levels. Copyright © 2017. Published by Elsevier Ltd.

  5. Twenty years experiences of Bamboo propagation at the potanical Garden of Cienfuegos, Cuba

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    Julio León Cabrera

    2011-07-01

    Full Text Available The Bamboo plants have fascinated growers and have motivated several specialists in their study due to their beauty and many applications. They are mostly originated in tropical and subtropical regions of the planet. In Cuba, the level of endemism is low and there are primarily herbaceous size species. For this reason, tree-sized woody species present in Cuba were introduced mainly by the Harvard Botanical Garden, Cienfuegos Botanical Garden today. The main objective is to study the economic potential and adaptation under the climatic conditions of Cuba, overlooking the extensive use of these resources. In previous years the use of these species has only been for emerging and craft work and its extension in reforestation plans has been limited. In 1989 began the first steps to encourage the cultivation and application of this wonder plant in our country. In this paper we show the results achieved in the propagation of bamboo in twenty years of work under different conditions. This helps to diversify the results in several provinces of the country with prospects for a local bamboo economy. Besides, it encourages job opportunities, satisfaction of many basic needs and import substitutions. Keyword: Poaceas, reforest, woody plants

  6. New and newer[The New Physics for the Twenty-First Century

    Energy Technology Data Exchange (ETDEWEB)

    Clark, C. [Electron and Optical Physics Division, National Institute of Standards and Technology, MD (United States)]. E-mail: clark@mail.nist.gov

    2006-09-15

    Stephen Hawking's inaugural lecture as Lucasian Professor of Mathematics at Cambridge University in 1980 caused quite a stir. Its title - 'Is the end in sight for theoretical physics?' - raised the prospect of a unified 'theory of everything'. Hawking suggested that there was a good chance of resolving the remaining inconsistencies between the two big 'theories of something' - quantum mechanics and general relativity - before the turn of the century. My first impression on reading The New Physics for the Twenty-First Century, a collection of essays edited by science journalist Gordon Fraser, is that a theory of everything may still be attainable by the turn of the century. However, there is now 20 times more of everything in the universe than there was in the past century, 95% of which no-one has ever actually seen, or had even heard of until a few years ago - as summarized in articles by Wendy Freedman, Edward Kolb and Ronald Adler. Despite this, Michael Green describes amazing developments in string theory that could tie everything together, if one could just figure out which, if any, of the apparently infinite varieties of string theory applies to our world, and why. (U.K.)

  7. Radiation exposures for DOE and DOE contractor employees, 1990. Twenty-third annual report

    Energy Technology Data Exchange (ETDEWEB)

    Smith, M.H.; Hui, T.E. [Pacific Northwest Lab., Richland, WA (United States); Millet, W.H.; Scholes, V.A. [Idaho National Engineering Lab., Idaho Falls, ID (United States)

    1994-03-01

    This is the 23rd in a series of annual radiation exposure reports published by the Department of Energy (DOE) or its predecessors. This report summarizes the radiation exposures received by both employees and visitors at DOE and DOE contractor facilities during 1990. Trends in radiation exposures are evaluated by comparing the doses received in 1990 to those received in previous years. The significance of the doses is addressed by comparing them to the DOE limits and by correlating the doses to health risks based on risk estimated from expert groups. This report is the third that is based on detailed exposure data for each individual monitored at a DOE facility. Prior to 1988, only summarized data from each facility were available. This report contains information on different types of radiation doses, including total effective, internal, penetrating, shallow, neutron, and extremity doses. It also contains analysis of exposures by age, sex, and occupation of the exposed individuals. This report also continues the precedent established in the Twenty-First (1988) Annual Report by conducting a detailed, one-time review and analysis of a particular topic of interest. The special topic for this report is a comparison of total effective, internal, and extremity dose equivalent values against penetrating dose equivalent values.

  8. Ukrainian Issues in Geopolitical thought of the Twentieth and Twenty-First Centuries

    Directory of Open Access Journals (Sweden)

    Reginia-Zacharski Jacek

    2016-12-01

    Full Text Available Ukrainian lands in the twentieth and twenty-first centuries have been in proximity of great geopolitical changes several times. During that time the Ukrainian nation – due to various factors – encountered a number of “windows of opportunity” for achieving the realization of dreams about independence and national sovereignty. The author identified in the period considered four “general moments,” of which two have been completed successfully. The first of these occurred in 1990–1991, when for the first time in modern history, Ukrainians managed to achieve a lasting and relatively stable independence. The second of the “moments” – still unresolved – are events that began in the late autumn of 2013. The process, called “Revolution of Dignity”, represents a new quality in the history of the Ukrainian nation, therefore, that the Ukrainians have to defend the status quo (independence, territorial integrity, sovereignty, etc. but not to seek to achieve an independent being. The analysis leads to the conclusion that the ability of Ukrainians to achieve and maintain independence is largely a function of the relative power of the Russian state as measured with respect to the shape and quality of international relations.

  9. Twenty years of society of medical informatics of b&h and the journal acta informatica medica.

    Science.gov (United States)

    Masic, Izet

    2012-03-01

    In 2012, Health/Medical informatics profession celebrates five jubilees in Bosnia and Herzegovina: a) Thirty five years from the introduction of the first automatic manipulation of data; b) Twenty five years from establishing Society for Medical Informatics BiH; c) Twenty years from establishing scientific and professional journal of the Society for Medical Informatics of Bosnia and Herzegovina "Acta Informatica Medica"; d) Twenty years from establishing first Cathdra for Medical Informatics on biomedical faculties in Bosnia and Herzegovina and e) Ten years from the introduction of "Distance learning" in medical curriculum. All of the five mentioned activities in the area of Medical informatics had special importance and gave appropriate contribution in the development of Health/Medical informatics in Bosnia And Herzegovina.

  10. Twenty Years of Society of Medical Informatics of B&H and the Journal Acta Informatica Medica

    Science.gov (United States)

    Masic, Izet

    2012-01-01

    In 2012, Health/Medical informatics profession celebrates five jubilees in Bosnia and Herzegovina: a) Thirty five years from the introduction of the first automatic manipulation of data; b) Twenty five years from establishing Society for Medical Informatics BiH; c) Twenty years from establishing scientific and professional journal of the Society for Medical Informatics of Bosnia and Herzegovina „Acta Informatica Medica“; d) Twenty years from establishing first Cathdra for Medical Informatics on biomedical faculties in Bosnia and Herzegovina and e) Ten years from the introduction of “Distance learning” in medical curriculum. All of the five mentioned activities in the area of Medical informatics had special importance and gave appropriate contribution in the development of Health/Medical informatics in Bosnia And Herzegovina. PMID:23322947

  11. Twenty-five years of continuous sulphur dioxide emission reduction in Europe

    Directory of Open Access Journals (Sweden)

    V. Vestreng

    2007-07-01

    Full Text Available During the last twenty-five years European emission data have been compiled and reported under the Cooperative Programme for Monitoring and Evaluation of the Long-range Transmission of Air Pollutants in Europe (EMEP as part of the work under the UNECE Convention on Long-range Transboundary Air Pollution (LRTAP. This paper presents emission trends of SO2 reported to EMEP and validated within the programme for the period 1980–2004. These European anthropogenic sulphur emissions have been steadily decreasing over the last twenty-five years, amounting from about 55 Tg SO2 in 1980 to 15 Tg SO2 in 2004. The uncertainty in sulphur emission estimates for individual countries and years are documented to range between 3% and 25%. The relative contribution of European emissions to global anthropogenic sulphur emissions has been halved during this period. Based on annual emission reports from European countries, three emission reduction regimes have been identified. The period 1980–1989 is characterized by low annual emission reductions (below 5% reduction per year and 20% for the whole period and is dominated by emission reductions in Western Europe. The period 1990–1999 is characterised by high annual emission reductions (up to 11% reduction per year and 54% for the whole period, most pronounced in Central and Eastern Europe. The annual emission reductions in the period 2000–2004 are medium to low (below 6% reduction per year and 17% for the whole period and reflect the unified Europe, with equally large reductions in both East and West. The sulphur emission reduction has been largest in the sector Combustion in energy and transformation industries, but substantial decreases are also seen in the Non-industrial combustion plants together with the sectors Industrial combustion and Industrial production processes. The majority of European countries have reduced their emissions by more than

  12. Personal networks and mortality risk in older adults: a twenty-year longitudinal study.

    Directory of Open Access Journals (Sweden)

    Lea Ellwardt

    Full Text Available Research on aging has consistently demonstrated an increased chance of survival for older adults who are integrated into rich networks of social relationships. Theoretical explanations state that personal networks offer indirect psychosocial and direct physiological pathways. We investigate whether effects on and pathways to mortality risk differ between functional and structural characteristics of the personal network. The objective is to inquire which personal network characteristics are the best predictors of mortality risk after adjustment for mental, cognitive and physical health.Empirical tests were carried out by combining official register information on mortality with data from the Longitudinal Aging Study Amsterdam (LASA. The sample included 2,911 Dutch respondents aged 54 to 85 at baseline in 1992 and six follow-ups covering a time span of twenty years. Four functional characteristics (emotional and social loneliness, emotional and instrumental support and four structural characteristics (living arrangement, contact frequency, number of contacts, number of social roles of the personal network as well as mental, cognitive and physical health were assessed at all LASA follow-ups. Statistical analyses comprised of Cox proportional hazard regression models. Findings suggest differential effects of personal network characteristics on survival, with only small gender differences. Mortality risk was initially reduced by functional characteristics, but disappeared after full adjustment for the various health variables. Mortality risk was lowest for older adults embedded in large (HR = 0.986, 95% CI 0.979-0.994 and diverse networks (HR = 0.948, 95% CI 0.917-0.981, and this effect continued to show in the fully adjusted models.Functional characteristics (i.e. emotional and social loneliness are indirectly associated with a reduction in mortality risk, while structural characteristics (i.e. number of contacts and number of social roles have

  13. Long-term geomorphological evolution in the Abruzzo area, Central Italy: twenty years of research

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    Miccadei Enrico

    2017-02-01

    Full Text Available The most recent research studies into the long-term landscape evolution of the Abruzzo area, carried out over the last twenty years at the “G. d’Annunzio” University of Chieti-Pescara, are based on an integrated approach incorporating structural geology and geomorphology and, in particular, the geomorphometry of topographic and hydrographic aspects, geological and structural-geomorphological surveys and mapping supported by morpho-stratigraphic and chronological constraints. The geomorphological analyses have allowed us to outline the main stages of geomorphological evolution and to identify the factors that have contributed to the landscape shaping of the Apennine Chain, the Adriatic Piedmont and the fluvial plains and coastal sectors, up to the Tremiti islands. In the Apennine Chain, landscape evolution — in a ridge, valley and basin system — is connected to the regional uplift, local tectonic subsidence and local base level variations, which have led to changes in the drainage systems, from exoreic to endorheic (in the intermontane basins and then to exoreic again. In the Adriatic Piedmont, landscape shaping is connected to uplifting and eustatic sea-level fluctuations, which have induced the formation of a structure-controlled drainage system and the shaping of systems of entrenched alluvial fans and large consequent river valleys, with flights of river terraces. In the coastal Adriatic area — composed of a coastal plain-coastal slope system (northern and southern coast and of a cliffed rocky coast (central coast, Tremiti interrupted by river valleys — landscape shaping is the result of selective erosion due to the interaction between marine geomorphic processes and slope processes connected to Late Quaternary eustatic fluctuations.

  14. Gendering inequality: a note on Piketty's Capital in the twenty-first century.

    Science.gov (United States)

    Perrons, Diane

    2014-12-01

    Thomas Piketty's Capital in the Twenty-First Century is remarkable for moving inequality from the margins to mainstream debate through detailed analysis of longitudinal statistics and, for an economist, by advocating an interdisciplinary perspective and writing in a witty and accessible style. With reference to the post 1970 period, when wage increases are largely responsible for the increase in inequality, Piketty shows how patrimonial capitalists (elite managers) in the top decile and centile of the distribution appropriate a growing share of social wealth as a consequence of their 'power to set their own remuneration' in the context of tolerant social norms rather than through their productive contributions. Piketty raises but defers the question of where these social norms come from to other disciplines. A Feminist Economics perspective indicates that these questions are central to a more inclusive form of economic analysis and such an approach would enrich Piketty's analysis in two main ways. First, by paying greater attention to the processes and social norms through which inequalities are produced and justified and second by highlighting the ways in which inequality is experienced differently depending not only on class, but also on other aspects of identity including gender. This approach also suggests that it is necessary to supplement the ex-post redistributive policies recommended by Piketty: a global wealth tax and more steeply progressive income tax, with ex-ante measures to stop the rise in wage inequality in the first place, especially by bridging the huge gulf that exists between those who care for people and those who manage money. © London School of Economics and Political Science 2014.

  15. Development of horse embryos up to twenty two days after ovulation: observations on fresh specimens.

    Science.gov (United States)

    Betteridge, K J; Eaglesome, M D; Mitchell, D; Flood, P F; Beriault, R

    1982-01-01

    Forty nine embryos, twenty unfertilized eggs and five other fresh eggs of 'doubtful' status have been recovered from 58 pony mares in 122 flushes up to 22 days after ovulation. The fresh egg or embryo recovery rate was 78% with surgical methods (or at slaughter) and 40-60% with non-surgical methods of recovery. The fertilization rate was about 70%. It has been confirmed that horse embryos normally enter the uterus as blastocysts 5-6 days after ovulation. Three features of early embryo morphology have become clearer upon comparison with unfertilized eggs of similar ages; early embryos are often ellipsoidal in shape; dispersal of most of a thick gel coat seems to be hastened by fertilization; gradual disappearance of refractile granules from the perivitelline space is similar in fertilized and unfertilized eggs. A tense, transparent, acellular capsule (considered to be different from the zona pellucida) is acquired by the spherical blastocysts within the uterus and persists at least until a diameter of 34 mm is attained (at 21 days in the present series). The capsule seems to be analogous, in part, with the 'neozona' described in rabbit blastocyst before attachment, and trophoblastic cells appear to be involved in its formation. Cleavage stages of oviductal embryos and diameters of uterine blastocysts from this series have been described and illustrated and used to extend previous knowledge of early growth patterns in horse embryos. Images Fig. 3 Fig. 4 Fig. 5 Fig. 6 Fig. 7 Fig. 8 Fig. 9 Fig. 10 Fig. 11 Fig. 12 Fig. 13 Fig. 14 Fig. 15 Fig. 16 Fig. 17 Fig. 18 Fig. 19 Fig. 20 Fig. 21 Fig. 22 Fig. 23 Fig. 24 Fig. 25 Fig. 26 Fig. 27 Fig. 28 Fig. 29 Fig. 30 Figs. 31-32 Figs. 33-34 Fig. 35 Fig. 36 Fig. 37 Fig. 38 Fig. 39 Fig. 40 Fig. 41 PMID:7130052

  16. Latvian Security and Defense Policy within the Twenty-First Century Security Environment

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    Rublovskis Raimonds

    2014-12-01

    Full Text Available The aim of this paper is to analyze fundamental factors which form and profoundly shape security and defense policy of the Republic of Latvia. One can argue that historical background, geographical location, common institutional history within the former Soviet Union, the Russia factor, the relative smallness of the territory of state and the population, the ethnic composition of the population, the low density of the population and rather limited financial and manpower resources available for the defense of the Republic of Latvia are the key factors of influence on the state security and defense policy. The core principles of the security and defense policy of Latvia are the membership in powerful global military alliance of NATO and bilateral strategic partnership with the United States. However, security and defense cooperation among the three Baltic States as well as enhanced cooperation within the Baltic-Nordic framework is seen as an important supplementary factor for the increased security of the Republic of Latvia. Latvia has developed a sustainable legal and institutional framework in order to contribute to state security and defense; however, security challenges and significant changes within the global security environment of the twenty-first century will further challenge the ability of the Republic of Latvia to sustain its current legal framework, and more importantly, current institutional structure of Latvian security and defense architecture. Significant internal and external challenges will impact the fundamental pillars of Latvian security and defense policy, such as American strategic shift to the Pacific, and lack of political will to increase defense budgets in European part of NATO. It has to be clear that very independence, security and defense of the Republic of Latvia depend on the ability of NATO to remain an effective organization with timely and efficient decision-making, and the ability of the United States to remain

  17. Yeast culture collections in the twenty-first century: new opportunities and challenges.

    Science.gov (United States)

    Boundy-Mills, Kyria L; Glantschnig, Ewald; Roberts, Ian N; Yurkov, Andrey; Casaregola, Serge; Daniel, Heide-Marie; Groenewald, Marizeth; Turchetti, Benedetta

    2016-07-01

    The twenty-first century has brought new opportunities and challenges to yeast culture collections, whether they are long-standing or recently established. Basic functions such as archiving, characterizing and distributing yeasts continue, but with expanded responsibilities and emerging opportunities. In addition to a number of well-known, large public repositories, there are dozens of smaller public collections that differ in the range of species and strains preserved, field of emphasis and services offered. Several collections have converted their catalogues to comprehensive databases and synchronize them continuously through public services, making it easier for users worldwide to locate a suitable source for specific yeast strains and the data associated with these yeasts. In-house research such as yeast taxonomy continues to be important at culture collections. Because yeast culture collections preserve a broad diversity of species and strains within a species, they are able to make discoveries in many other areas as well, such as biotechnology, functional, comparative and evolution genomics, bioprocesses and novel products. Due to the implementation of the Convention of Biological Diversity (CBD) and the Nagoya Protocol (NP), there are new requirements for both depositors and users to ensure that yeasts were collected following proper procedures and to guarantee that the country of origin will be considered if benefits arise from a yeast's utilization. Intellectual property rights (IPRs) are extremely relevant to the current access and benefit-sharing (ABS) mechanisms; most research and development involving genetic resources and associated traditional knowledge will be subject to this topic. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  18. Some Observations on Cultural Opposites in Contemporary China: Kunming and Beijing Twenty Years Later

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    Vesna Vučinić-Nešković

    2016-02-01

    Full Text Available This paper considers the cultural opposites observed in various segments of Chinese culture during the author's three stays in China over a period of twenty years. The first and second stay, in 1986 and 1989 respectively, coincided with the initial period of the implementation of modernization reforms in China, when their results were just beginning to be felt. The third stay was in 2009, towards the end of the third decade of reform implementation, at the time of an already developed marketoriented communism. The paper's main thesis is that most of the phenomena observed in present-day urban China can be assigned to opposite categories, namely Chinese-Western and traditional- contemporary. Cultural opposites have been observed in the sphere of tourism and the behavior of both Chinese and foreign visitors, in the use of Chinese and English in notices and signs in public places, and in the promotion of traditional and modern architecture. In addition, they have been noted in the presentation of arts and crafts and industrial products, in the manner of consumption of hot drinks, and in the combining of Chinese and foreign cuisine. They are also evident in a Beijing Opera performance adapted both to the modern Chinese and to foreigners, and in the traditional Chinese exercises and western dances performed in public parks. In conclusion, the paper suggests that the process of establishing connections between China and the West is being carried on in a moderate and controlled way. In the globalization process cultural opposites coexist and merge, imparting new features to Chinese culture.

  19. Higher Alu methylation levels in catch-up growth in twenty-year-old offsprings.

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    Kittipan Rerkasem

    Full Text Available Alu elements and long interspersed element-1 (LINE-1 or L1 are two major human intersperse repetitive sequences. Lower Alu methylation, but not LINE-1, has been observed in blood cells of people in old age, and in menopausal women having lower bone mass and osteoporosis. Nevertheless, Alu methylation levels also vary among young individuals. Here, we explored phenotypes at birth that are associated with Alu methylation levels in young people. In 2010, 249 twenty-years-old volunteers whose mothers had participated in a study association between birth weight (BW and nutrition during pregnancy in 1990, were invited to take part in our present study. In this study, the LINE-1 and Alu methylation levels and patterns were measured in peripheral mononuclear cells and correlated with various nutritional parameters during intrauterine and postnatal period of offspring. This included the amount of maternal intake during pregnancy, the mother's weight gain during pregnancy, birth weight, birth length, and the rate of weight gain in the first year of life. Catch-up growth (CUG was defined when weight during the first year was >0.67 of the standard score, according to WHO data. No association with LINE-1 methylation was identified. The mean level of Alu methylation in the CUG group was significantly higher than those non-CUG (39.61% and 33.66 % respectively, P < 0.0001. The positive correlation between the history of CUG in the first year and higher Alu methylation indicates the role of Alu methylation, not only in aging cells, but also in the human growth process. Moreover, here is the first study that demonstrated the association between a phenotype during the newborn period and intersperse repetitive sequences methylation during young adulthood.

  20. TWENTY-FIVE-GAUGE PARS PLANA VITRECTOMY IN COMPLEX RETINAL DETACHMENTS ASSOCIATED WITH GIANT RETINAL TEAR.

    Science.gov (United States)

    Kumar, Vinod; Kumawat, Devesh; Bhari, Anju; Chandra, Parijat

    2017-03-22

    To study the structural and functional outcomes of 25-gauge pars plana vitrectomy in giant retinal tear-associated retinal detachments. Seventeen eyes of 17 patients with giant retinal tear, who underwent 25-gauge pars plana vitrectomy over a period of 15 months at a tertiary eye care center by a single surgeon, were recruited in this retrospective interventional study. Giant retinal tears were mostly traumatic (35.3%) or associated with myopia (35.3%) and occurred in young (mean age 25.7 years) males (94.1%). Most eyes had best-corrected visual acuity ≤20/1,200 (in 82.3%), foveal detachment (in 88.2%), and proliferative vitreoretinopathy ≤Grade B (in 82.3%). The giant retinal tear extent was more than 180° in 29.4% and the fellow eye was involved in 35.2% of eyes. All eyes underwent 25-gauge pars plana vitrectomy with encircling band in 41.1%, perfluorocarbon liquid use in 82.3%, and endotamponade with sulphur hexafluoride (23.6%) or silicone oil (76.4%). At mean follow-up of 10.2 months, reattachment rate was 88.2%. Only 35.2% of eyes achieved final visual acuity ≥20/80 with a cause of poor vision being cataract, secondary glaucoma, macular pucker, and corneal edema. Twenty-five-gauge pars plana vitrectomy can achieve excellent attachment rates in eyes with giant retinal tear-associated retinal detachment. It can be as efficient as larger-gauge vitrectomy, at the same time retaining all advantages of smaller-gauge surgery.

  1. Strong Inference in Mathematical Modeling: A Method for Robust Science in the Twenty-First Century.

    Science.gov (United States)

    Ganusov, Vitaly V

    2016-01-01

    While there are many opinions on what mathematical modeling in biology is, in essence, modeling is a mathematical tool, like a microscope, which allows consequences to logically follow from a set of assumptions. Only when this tool is applied appropriately, as microscope is used to look at small items, it may allow to understand importance of specific mechanisms/assumptions in biological processes. Mathematical modeling can be less useful or even misleading if used inappropriately, for example, when a microscope is used to study stars. According to some philosophers (Oreskes et al., 1994), the best use of mathematical models is not when a model is used to confirm a hypothesis but rather when a model shows inconsistency of the model (defined by a specific set of assumptions) and data. Following the principle of strong inference for experimental sciences proposed by Platt (1964), I suggest "strong inference in mathematical modeling" as an effective and robust way of using mathematical modeling to understand mechanisms driving dynamics of biological systems. The major steps of strong inference in mathematical modeling are (1) to develop multiple alternative models for the phenomenon in question; (2) to compare the models with available experimental data and to determine which of the models are not consistent with the data; (3) to determine reasons why rejected models failed to explain the data, and (4) to suggest experiments which would allow to discriminate between remaining alternative models. The use of strong inference is likely to provide better robustness of predictions of mathematical models and it should be strongly encouraged in mathematical modeling-based publications in the Twenty-First century.

  2. TWENTY-YEAR PLANNING STUDY FOR THE RELATIVISTIC HEAVY ION COLLIDER FACILITY AT BROOKHAVEN NATIONAL LABORATORY.

    Energy Technology Data Exchange (ETDEWEB)

    LUDLAM,T.ET AL.

    2003-12-31

    At the request of DOE's Office of Nuclear Physics (ONP), Brookhaven National Laboratory (BNL) has created this planning document to assemble and summarize a planning exercise that addresses the core scientific thrust of the Relativistic Heavy Ion Collider (RHIC) for the next twenty years and the facilities operation plan that will support this program. The planning work was carried out by BNL in close collaboration with the RHIC user community and within budgetary guidelines for the next five years supplied by the ONP. The resulting plans were reviewed by the BNL High Energy and Nuclear Physics Program Advisory Committee (PAC) at a special RHIC planning meeting held in December 2003. Planning input from each of the four RHIC experimental collaborations was absolutely central to the preparation of this overall Laboratory plan. Each collaboration supplied two key documents, a five-year ''Beam Use Proposal'' and a ten-year ''Decadal Plan''. These plans are posted on the BNL website http://www.bnl.gov/henp/, along with other planning documents germane to this paper, such as the complete written reports from the August and December 2003 PAC meetings that considered the five-year and decadal planning documents of the four RHIC collaborations and offered advice and commentary on these plans. Only in these collaboration documents can the full physics impact of the RHIC program be seen and the full scope of the efforts put into this planning process be appreciated. For this reason, the maximum value of the present planning paper can only be realized by making frequent reference to the collaboration documents.

  3. Nutritional composition and antioxidant activity of twenty mung bean cultivars in China

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    Zhenxing Shi

    2016-10-01

    Full Text Available Interest in mung bean (Vigna radiata L. as a functional food is growing; however, studies on the nutritional composition of major mung bean cultivars planted in China are limited. Twenty Chinese mung bean cultivars were collected and their nutritional compositions including starch, fat, protein, and phytochemicals were analyzed. The cultivars were found to have a high amount of resistant starch, accounting for 16.1%–22.3% of total starch, and balanced amino acid constitutions. Palmitic acid and linoleic acid were the two dominant fatty acids, accounting for respectively 32.4% and 36.1% of all of the assayed fatty acids. Four bound phenolic acids (syringic, caffeic, p-coumaric, and ferulic acids and two free phenolic acids (caffeic and ferulic acids were identified by HPLC. The antioxidant activity of 70% ethanol extracts from the 20 mung bean cultivars was evaluated. Their DPPH and ABTS+ free-radical-scavenging capacity ranged from 28.13 ± 2.24 to 35.68 ± 0.71 μmol g−1 and from 3.82 ± 0.25 to 13.44 ± 1.76 μmol g−1, respectively. Significant positive correlations of ABTS+ free-radical-scavenging capacity with total phenolic acids and total flavonoid contents were observed. These results suggest that Chinese mung bean cultivars are rich in balanced nutrients and that their phytochemicals should be considered as potential sources of natural antioxidants.

  4. Preparation of European Public Health Professionals in the Twenty-first Century.

    Science.gov (United States)

    Bjegovic-Mikanovic, Vesna; Otok, Robert

    2017-01-01

    The public health profession in Europe has a leadership role for ensuring European's health in the twenty-first century and therefore must assume responsibility for advancing education for research and practice. Three fundamental questions are explored: (1) What are the main public health problems facing public health professionals; (2) What are their existing competencies after training; and (3) What competencies do European employers expect? The European Schools of Public Health assessed their best success to be in the field of health promotion, followed by disease prevention including identification of priority health problems, and elimination of health hazards in the community. Conversely, they see the least success in dealing with preparedness and planning for public health emergencies. From an employer's perspective, significant gaps between current and desired levels of performance at the job exist for all Essential Public Health Operations of World Health Organization. Based on prior research and recent European surveys of Schools and Departments of Public Health, the following recommendations are made, which emphasize the leadership role of the European public health community: (1) the preparation of public health professionals requires an interface between public health functions, competencies, and performance; (2) competence-based education is important and allows debates on the scope of the required education; (3) governments have to realize that the present lack of infrastructure and capacity is detrimental to the people's health; (4) as public health challenges are increasingly global, educational institutions have to look beyond the national boundaries and participate in European and global networks for education, research, and practice.

  5. Twenty-year survey of the epidemiology of hepatitis B in Denmark: effect of immigration

    DEFF Research Database (Denmark)

    Gjørup, I E; Smith, E; Borgwardt, L

    2003-01-01

    Implementation of hepatitis B virus (HBV) vaccination is being considered in Denmark. Therefore, a 20 y survey on the epidemiology of HBV infection was performed. All notified cases of acute HBV infection in Denmark from 1982 to 2002 were reviewed retrospectively and all available data from 1970...... to 2001 on the prevalence of hepatitis B surface antigen (HBsAg) in different groups of the Danish population were studied. The notified annual incidence of acute HBV infection has declined from more than 200 cases to fewer than 50 cases in 2001. In the indigenous population there has been a similar...... decline in prevalence of HBsAg carriers, from 0.15 to 0.03%, but owing to immigration of new HBsAg carriers from developing countries the overall number of carriers has not changed. The small effect of immigration on the incidence of acute HBV infections as well as the decreasing prevalence of HBs...

  6. Twenty-year survey of the epidemiology of hepatitis B in Denmark: effect of immigration

    DEFF Research Database (Denmark)

    Gjørup, I E; Smith, E; Borgwardt, L

    2003-01-01

    Implementation of hepatitis B virus (HBV) vaccination is being considered in Denmark. Therefore, a 20 y survey on the epidemiology of HBV infection was performed. All notified cases of acute HBV infection in Denmark from 1982 to 2002 were reviewed retrospectively and all available data from 1970...... to 2001 on the prevalence of hepatitis B surface antigen (HBsAg) in different groups of the Danish population were studied. The notified annual incidence of acute HBV infection has declined from more than 200 cases to fewer than 50 cases in 2001. In the indigenous population there has been a similar......Ag carriers among Danes should be taken into account when planning new vaccination strategies in Denmark....

  7. Twenty-first century science as a relational process: from eureka! to team science and a place for community psychology.

    Science.gov (United States)

    Tebes, Jacob Kraemer; Thai, Nghi D; Matlin, Samantha L

    2014-06-01

    In this paper we maintain that twenty-first century science is, fundamentally, a relational process in which knowledge is produced (or co-produced) through transactions among researchers or among researchers and public stakeholders. We offer an expanded perspective on the practice of twenty-first century science, the production of scientific knowledge, and what community psychology can contribute to these developments. We argue that: (1) trends in science show that research is increasingly being conducted in teams; (2) scientific teams, such as transdisciplinary teams of researchers or of researchers collaborating with various public stakeholders, are better able to address complex challenges; (3) transdisciplinary scientific teams are part of the larger, twenty-first century transformation in science; (4) the concept of heterarchy is a heuristic for team science aligned with this transformation; (5) a contemporary philosophy of science known as perspectivism provides an essential foundation to advance twenty-first century science; and (6) community psychology, through its core principles and practice competencies, offers theoretical and practical expertise for advancing team science and the transformation in science currently underway. We discuss the implications of these points and illustrate them briefly with two examples of transdisciplinary team science from our own work. We conclude that a new narrative is emerging for science in the twenty-first century that draws on interpersonal transactions in teams, and active engagement by researchers with the public to address critical accountabilities. Because of its core organizing principles and unique blend of expertise on the intersection of research and practice, community psychologists are well-prepared to help advance these developments, and thus have much to offer twenty-first century science.

  8. Twenty years of gastroenteropancreatic neuroendocrine tumors: is reclassification worthwhile and feasible?

    Science.gov (United States)

    Grillo, Federica; Albertelli, Manuela; Annunziata, Francesca; Boschetti, Mara; Caff, Andrea; Pigozzi, Simona; Ferone, Diego; Mastracci, Luca

    2016-07-01

    Gastroenteropancreatic (GEP) neuroendocrine tumors (NETs) are rare neoplasms with heterogeneous clinical behavior and potential long-term survival. In 2006/2007, the European Neuroendocrine Tumors Society introduced an important parameter, grade (based on mitoses and Ki-67 proliferation rate), which became part of the latest 2010-WHO classification. Since this is an important tool in the choice of therapeutic algorithm of patients with NETs, our aim was to audit whether retrospective reclassification is possible and feasible and correlate pathological findings with survival. From the histopathology archive, 338 GEP-NETs (1994-2014) were identified, of which 250 were diagnosed pre-2010 and 80 of these have needed, up till now, classification (morphology and grade-mitotic count/Ki-67). Morphology was well differentiated (WD) in 74 cases while only 6 cases were poorly differentiated (PD). Grade was reclassified: G1-45 cases (56 %); G2-28 cases (35 %); G3-7 cases (9 %). Overall survival (OS) in WD NETs was strikingly better compared to PD neoplasms. Differences in OS between grade were statistically significant (p < 0.0001) and, in particular, grade identified a subgroup of patients with WD lesions but with less favorable clinical behavior (OS at 5 years: G1-89 %; G2-48 %; G3-0 %; G1 vs G2 p = 0.03). Feasibility analysis quantified time for reclassification to be between 45 and 64 min/case. Our series confirms the importance of grade in prognostic stratification and underlines that reclassification is feasible, and may prove worthwhile in patient management, especially in view of the potential long survival of patients with NETs and risk of use of inappropriate therapies.

  9. The Significance, for Readers in the Twenty-first Century, of the Character of Safie in Mary Shelley's Frankestein

    OpenAIRE

    Esther Katheu Mbithi

    2017-01-01

    The Significance, for Readers in the Twenty-first century, of the Character of Safie in Mary Shelley's Frankenstein. Abstract: This paper presents a critical look at one of the characters in Mary Shelley’s Frankenstein, Safie, through the lenses of a female African scholar in the twenty-first century. A close look at the narrative structure leads to the gradual peeling off of the first two layers, to the core of the narration. The paper looks keenly at a minor character in this core, in the l...

  10. Methylation profiling of twenty promoter-CpG islands of genes which may contribute to hepatocellular carcinogenesis.

    Science.gov (United States)

    Yu, Jian; Ni, Min; Xu, Jian; Zhang, Hongyu; Gao, Baomei; Gu, Jianren; Chen, Jianguo; Zhang, Lisheng; Wu, Mengchao; Zhen, Sushen; Zhu, Jingde

    2002-11-15

    Hepatocellular carcinoma (HCC) presents one of the major health threats in China today. A better understanding of the molecular genetics underlying malignant transformation of hepatocytes is critical to success in the battle against this disease. The methylation state of C5 of the cytosine in the CpG di-nucleotide that is enriched within or near the promoter region of over 50 % of the polymerase II genes has a drastic effect on transcription of these genes. Changes in the methylation profile of the promoters represent an alternative to genetic lesions as causative factors for the tumor-specific aberrant expression of the genes. We have used the methylation specific PCR method in conjunction with DNA sequencing to assess the methylation state of the promoter CpG islands of twenty genes. Aberrant expression of these genes have been attributed to the abnormal methylation profile of the corresponding promoter CpG islands in human tumors. While the following sixteen genes remained the unmethylated in all tumor and normal tissues: CDH1, APAF1, hMLH1, BRCA1, hTERC, VHL, RARbeta, TIMP3, DAPK1, SURVIVIN, p14ARF, RB1, p15INK4b, APC, RASSF1c and PTEN, varying degrees of tumor specific hypermethylation were associated with the p16INK4a, RASSF1a, CASP8 and CDH13 genes. For instance, the p16INK4a was highly methylated in HCC (17/29, 58.6%) and less significantly methylated in non-cancerous tissue (4/29. 13.79%). The RASSF1a was fully methylated in all tumor tissues (29/29, 100%), and less frequently methylated in corresponding non-cancerous tissue (24/29, 82.75%). Furthermore, co-existence of methylated with unmethylated DNA in some cases suggested that both genetic and epigenetic (CpG methylation) mechanisms may act in concert to inactivate the p16INK4a and RASSF1a in HCC. Finally, we found a significant association of cirrhosis with hypermethylation of the p16INK4a and hypomethylation of the CDH13 genes. For the first time, the survey was carried out on such an extent that it

  11. Methylation profiling of twenty promoter-CpG islands of genes which may contribute to hepatocellular carcinogenesis

    Directory of Open Access Journals (Sweden)

    Zhang Lisheng

    2002-11-01

    Full Text Available Abstract Background Hepatocellular carcinoma (HCC presents one of the major health threats in China today. A better understanding of the molecular genetics underlying malignant transformation of hepatocytes is critical to success in the battle against this disease. The methylation state of C5 of the cytosine in the CpG di-nucleotide that is enriched within or near the promoter region of over 50 % of the polymerase II genes has a drastic effect on transcription of these genes. Changes in the methylation profile of the promoters represent an alternative to genetic lesions as causative factors for the tumor-specific aberrant expression of the genes. Methods We have used the methylation specific PCR method in conjunction with DNA sequencing to assess the methylation state of the promoter CpG islands of twenty genes. Aberrant expression of these genes have been attributed to the abnormal methylation profile of the corresponding promoter CpG islands in human tumors. Results While the following sixteen genes remained the unmethylated in all tumor and normal tissues: CDH1, APAF1, hMLH1, BRCA1, hTERC, VHL, RARβ, TIMP3, DAPK1, SURVIVIN, p14ARF, RB1, p15INK4b, APC, RASSF1c and PTEN, varying degrees of tumor specific hypermethylation were associated with the p16INK4a , RASSF1a, CASP8 and CDH13 genes. For instance, the p16INK4a was highly methylated in HCC (17/29, 58.6% and less significantly methylated in non-cancerous tissue (4/29. 13.79%. The RASSF1a was fully methylated in all tumor tissues (29/29, 100%, and less frequently methylated in corresponding non-cancerous tissue (24/29, 82.75%. Conclusions Furthermore, co-existence of methylated with unmethylated DNA in some cases suggested that both genetic and epigenetic (CpG methylation mechanisms may act in concert to inactivate the p16INK4a and RASSF1a in HCC. Finally, we found a significant association of cirrhosis with hypermethylation of the p16INK4a and hypomethylation of the CDH13 genes. For the

  12. Twenty years of electroconvulsive therapy in a psychiatric unit at a university general hospital

    Directory of Open Access Journals (Sweden)

    Amilton dos Santos Jr.

    2013-01-01

    Full Text Available Objective: To describe the sociodemographic and clinical profile of patients who underwent electroconvulsive therapy (ECT at a university general hospital. Method: In this retrospective study, records from all patients undergoing ECT between January 1988 and January 2008 at the psychiatric unit of the general hospital of Universidade Estadual de Campinas (UNICAMP were reviewed. Telephone contact was made with patients/relatives to collect follow-up data. Results: A total of 200 charts were reviewed. The majority of patients were women, with a mean age of 39 years, and history of psychiatric hospitalization. The main indications for ECT were depression and catatonia. Complications were observed in less than half of the cases, and most were temporary and not severe. There was a good psychiatric outcome for 89.7% of the patients, especially for catatonic patients (100%, p = 0.02. Thirty-four percent of the cases were later contacted by telephone calls, at a mean of 8.5 years between the procedure and the contact. Among these, three (1.5% reported persistent memory disorders and 73% considered ECT a good treatment. Conclusion: ECT has been performed according to international guidelines. In the vast majority of cases, undesirable effects were temporary and not severe. Response to ECT was positive in most cases, particularly in catatonic patients.

  13. The Twenty-First Century Multiple Generation Workforce: Overlaps and Differences but Also Challenges and Benefits

    Science.gov (United States)

    Helyer, Ruth; Lee, Dionne

    2012-01-01

    Purpose: The purpose of this paper is to explore the issues around a multiple generational workforce and more specifically, the challenges and benefits for education providers and employers. Design/methodology/approach: Reviewing research papers, analysing academic texts, interrogating market intelligence and contextualising case studies, the…

  14. Germ Cell Tumours in Children: A Twenty-year Retrospective Study ...

    African Journals Online (AJOL)

    Background: There is a significant lack of studies of germ cell neoplasms in the paediatric age group from Nigeria and other parts of Africa. Objectives: The aim of this study was to determine the histological pattern of paediatric germ cell tumours in Ibadan, Nigeria. Method: This is a retrospective study of cases of germ cell ...

  15. Anthropologists and Missionaries. Part II. Studies in Third World Societies. Publication Number Twenty-Six.

    Science.gov (United States)

    Salamone, Frank A., Ed.

    The topics of anthropologist-missionary relationships, theology and missiology, research methods and missionary contributions to ethnology, missionary training and methods, and specific case studies are presented. The ten essays are: (1) "An Ethnoethnography of Missionaries in Kalingaland" (Robert Lawless); (2) "Missionization and…

  16. Intergenerational Practice: Mentoring and Social Capital for Twenty-First Century Communities of Practice

    Science.gov (United States)

    Cumming-Potvin, Wendy Marie; MacCallum, Judith

    2010-01-01

    Aiming to elucidate the relationship between social capital and intergenerational practice within mentoring, this article presents data from a case study of the School Volunteer Program in Western Australia. Drawing on situated learning theory and the concept of community of practice (Lave & Wenger, 1991; Wenger, 1998; Wenger, McDermott, &…

  17. Student Workers: Essential Partners in the Twenty-First Century Academic Library

    Science.gov (United States)

    Logan, Firouzeh

    2012-01-01

    This article describes a case study that best illustrates the value of student workers in university libraries, focusing particularly on how this kind of creative endeavor benefits everyone involved--the library, the students, the faculty, and at the end of the project: the university community. (Contains 1 table.)

  18. Twenty-two years of HIV infection in Bhutan: epidemiological profile.

    Science.gov (United States)

    Tshering, Pandup; Lhazeen, Karma; Wangdi, Sonam; Tshering, Namgay

    2016-11-28

    To describe the HIV epidemiology in Bhutan. Data from the database of people living with HIV infection in Bhutan, survey reports from the National STI and HIV/AIDS Control Programme from the Ministry of Health and published literature on HIV in Bhutan were reviewed. Bhutan continues to have a low HIV prevalence with only 470 cases reported by the end of 2015. However, there is a slow but steady recent increase in the number of cases. The main mode of transmission is unsafe heterosexual practice in the general population and is occurring mostly in urban and business districts. More than half of cases have been diagnosed in only three districts. Although the number of cases among key populations such as sex workers and intravenous drug users remains significantly low, the information available remains very limited. There is only scarce published literature on HIV in Bhutan and an absence of a strategic surveillance system. A high level of sexually transmitted infections and multiple sexual relationships represent the existing threats that may fuel a larger epidemic. Bhutan has a maintained a low HIV prevalence over the past two decades, which is reflected in the national response to HIV. However, with the presence of existing and newly emerging risk factors, this response needs to adapt continually. To ensure that HIV prevalence remains low, it is crucial to invest in a strategic information system to monitor rates of infections to guide the public health response.

  19. Twenty-Nine New Limonoids with Skeletal Diversity from the Mangrove Plant, Xylocarpus moluccensis

    Directory of Open Access Journals (Sweden)

    Jianzhi Zhang

    2018-01-01

    Full Text Available Twenty-nine new limonoids—named xylomolins A1–A7, B1–B2, C1–C2, D–F, G1–G5, H–I, J1–J2, K1–K2, L1–L2, and M–N, were isolated from the seeds of the mangrove plant, Xylocarpus moluccensis. Compounds 1–13 are mexicanolides with one double bond or two conjugated double bonds, while 14 belongs to a small group of mexicanolides with an oxygen bridge between C1 and C8. Compounds 15–19 are khayanolides containing a Δ8,14 double bond, whereas 20 and 21 are rare khayanolides containing a Δ14,15 double bond and Δ8,9, Δ14,15 conjugated double bonds, respectively. Compounds 22 and 23 are unusual limonoids possessing a (Z-bicyclo[5.2.1]dec-3-en-8-one motif, while 24 and 25 are 30-ketophragmalins with Δ8,9, Δ14,15 conjugated double bonds. Compounds 26 and 27 are phragmalin 8,9,30-ortho esters, whereas 28 and 29 are azadirone and andirobin derivatives, respectively. The structures of these compounds, including absolute configurations of 15–19, 21–23, and 26, were established by HRESIMS, extensive 1D and 2D NMR investigations, and the comparison of experimental electronic circular dichroism (ECD spectra. The absolute configuration of 1 was unequivocally established by single-crystal X-ray diffraction analysis, obtained with Cu Kα radiation. The diverse cyclization patterns of 1–29 reveal the strong flexibility of skeletal plasticity in the limonoid biosynthesis of X. moluccensis. Compound 23 exhibited weak antitumor activity against human triple-negative breast MD-MBA-231 cancer cells with an IC50 value of 37.7 μM. Anti-HIV activities of 1, 3, 8, 10, 11, 14, 20, 23–25, and 27 were tested in vitro. However, no compounds showed potent inhibitory activity.

  20. Learning by Doing: Twenty Successful Active Learning Exercises for Information Systems Courses

    Directory of Open Access Journals (Sweden)

    Alanah Mitchell

    2017-01-01

    Full Text Available Aim/Purpose: This paper provides a review of previously published work related to active learning in information systems (IS courses. Background: There are a rising number of strategies in higher education that offer promise in regards to getting students’ attention and helping them learn, such as flipped classrooms and offering courses online. These learning strategies are part of the pedagogical technique known as active learning. Active learning is a strategy that became popular in the early 1990s and has proven itself as a valid tool for helping students to be engaged with learning. Methodology: This work follows a systematic method for identifying and coding previous research based on an aspect of interest. The authors identified and assessed research through a search of ABI/Inform scholarly journal abstracts and keywords, as well as additional research databases, using the search terms “active learning” and “information systems” from 2000 through June 2016. Contribution: This synthesis of active learning exercises provides guidance for information technology faculty looking to implement active learning strategies in their classroom by demonstrating how IS faculty might begin to introduce more active learning techniques in their teaching as well as by presenting a sample teaching agenda for a class that uses a mix of active and passive learning techniques to engage student learning. Findings: Twenty successful types of active learning exercises in IS courses are presented. Recommendations for Practitioners\t: This paper offers a “how to” resource of successful active learning strategies for IS faculty interested in implementing active learning in the classroom. Recommendation for Researchers: This work provides an example of a systematic literature review as a means to assess successful implementations of active learning in IS. Impact on Society: An updated definition of active learning is presented as well as a meaningful

  1. Structure-activity relationship of dendrimers engineered with twenty common amino acids in gene delivery.

    Science.gov (United States)

    Wang, Fei; Hu, Ke; Cheng, Yiyun

    2016-01-01

    Systematic explorations on the structure-activity relationship of surface-engineered dendrimers are essential to design high efficient and safe gene vectors. The chemical diversity of residues in naturally occurring amino acids allows us to generate a library of dendrimers with various surface properties. Here, we synthesized a total number of 40 dendrimers engineered with the twenty common amino acids and investigated their performances in gene delivery. The results show that gene transfection efficacy of the synthesized materials depends on both the type of amino acid and the conjugation ratio. Dendrimers engineered with cationic and hydrophobic amino acids possess relatively higher transfection efficacies. Engineering dendrimers with cationic amino acids such as arginine and lysine facilitates polyplex formation and cellular uptake, with histidine improves endosomal escape of the polyplexes, and with hydrophobic amino acids such as tyrosine and phenylalanine modulates the balance between hydrophobicity and hydrophilicity on dendrimer surface, which is beneficial for efficient cellular internalization. Dendrimers engineered with anionic or hydrophilic amino acids show limited transfection efficacy due to poor DNA binding capacity and/or limited cellular uptake. In the aspect of cytotoxicity, dendrimers engineered with arginine, lysine, tyrosine, phenylalanine and tryptophan show much higher cytotoxicity than other engineered dendrimers. These results are helpful for us to tailor the surface chemistry of dendrimers for efficient gene delivery. Cationic polymers such as dendrimers were widely used as gene vectors but are limited by relatively low delivery efficacy and high toxicity. To achieve efficient and low toxic gene delivery, the polymers were modified with various ligands. However, these ligand-modified polymers in gene delivery are reported by independent researchers using different polymer scaffolds and cell lines. It is hard to provide structure

  2. Childhood adiposity trajectories are associated with late adolescent blood pressure: birth to twenty cohort.

    Science.gov (United States)

    Munthali, Richard J; Kagura, Juliana; Lombard, Zané; Norris, Shane A

    2016-07-29

    Elevated blood pressure in childhood is a risk factor for adult hypertension which is a global health problem. Excess adiposity in childhood creates a predisposition to develop adult hypertension. Our aim was to explore distinct sex-specific adiposity trajectories from childhood to late adolescence and examined their association with blood pressure. Latent Class Growth Mixture Modeling (LCGMM) on longitudinal data was used to derive sex-specific and distinct body mass index (BMI: kg/m(2)) trajectories. We studied 1824 black children (boys = 877, girls = 947) from the Birth to Twenty (Bt20) cohort from Soweto, South Africa, and obtained BMI measures at ages 5 through 18 years. Participants with at least two age-point BMI measures, were included in the analysis. Analysis of variance (ANOVA), chi-square test, multivariate linear and standard logistic regressions were used to test study characteristics and different associations. We identified three (3) and four (4) distinct BMI trajectories in boys and girls, respectively. The overall prevalence of elevated blood pressure (BP) was 34.9 % (39.4 % in boys and 30.38 % in girls). Boys and girls in the early onset obesity or overweight BMI trajectories were more likely to have higher BP values in late adolescence. Compared to those in the normal weight BMI trajectory, girls in early onset obesity trajectories had an increased risk of elevated BP with odds ratio (OR) of 2.18 (95 % confidence interval 1.31 to 4.20) and 1.95 (1.01 to 3.77). We also observed the weak association for boys in early onset overweight trajectory, (p-value = 0.18 and odds ratio of 2.39 (0.67 to 8.57)) CONCLUSIONS: Distinct weight trajectories are observed in black South African children from as early as 5 years. Early onset adiposity trajectories are associated with elevated BP in both boys and girls. It is important to consider individual patterns of early-life BMI development, so that intervention strategies can be targeted to at

  3. Symptom experience and subsequent mortality: results from the West of Scotland Twenty-07 study

    Directory of Open Access Journals (Sweden)

    Wyke Sally

    2006-12-01

    Full Text Available Abstract Background Associations between symptom experience and mortality have rarely been investigated. One study has suggested that the number of symptoms people experience may be an important predictor of mortality. This novel and potentially important finding may have important implications but needs to be tested in other cohorts. Methods 858 people aged around 58 years were interviewed by nurses in 1990/1 as part of the West of Scotland Twenty-07 Study. They were asked about the presence of symptoms in the last month from a checklist of 33 symptoms. Measures of morbidity included symptom type (respiratory, musculoskeletal, gastrointestinal, mental health, neurological, systemic and symptom summary measures looking at the number and impact of symptoms (total number; number participants tended to have; number participants did not tend to have; number which restricted usual activities; number which led to GP consultation. Hazard ratios for thirteen-year all-cause mortality were calculated for symptom types, symptom summary measures, and self-assessed health with and without adjustment. Results On unadjusted analysis, and after adjusting for gender, socio-economic status and smoking, mortality was elevated in individuals reporting respiratory, systemic and mental health symptoms. After additional adjustment for chronic conditions and self-assessed health, only the association between mental health symptoms and mortality remained significant. On unadjusted analysis, and after adjusting for gender, socio-economic status and smoking, mortality was elevated in individuals with many (≥ 6 symptoms in four of the symptom summary measures examined. These relationships were no longer significant after additional adjustment for chronic conditions and self-assessed health. A clear trend of increasing mortality as self-assessed health became poorer was observed. This pattern remained statistically significant after adjustment for gender, socio

  4. Ten Years, Twenty Issues, and Two Hundred Papers of Numeracy: Toward International Reach and Transdisciplinary Utility

    Directory of Open Access Journals (Sweden)

    H.L. Vacher

    2017-07-01

    Full Text Available This issue completes the first ten years of Numeracy. The purpose of this introductory editorial is to review what has happened to the journal in those ten years. In the twenty issues, Numeracy’s output has been 201 papers counting the one or two editorials per issue. More than 50% of the papers are full, peer-reviewed articles, including 13 papers in two theme collections. The others are peer-reviewed notes and perspectives, editor-reviewed book reviews (15% of the total, and a column by contributing co-editor, Dorothy Wallace. The current issue marks an upswing in the number of notes, and our first discussion/reply. The number of papers per year has been increasing (e.g., 66% more in the last three years than in the first three years. The download rate has increased from about 5,000 in the first two years to 5,000 in about 40 days now. The editorial goes on to document two main outcomes. First, the journal is gaining an international reach: more than half the downloads occur outside the United States now, and the number of contributions from outside the United States has increased from 4 in the first five years to 15 in the second five years. Second, the across-the-curriculum nature of quantitative literacy is coming to the fore. The transdisciplinarity of QL is strikingly evident in this issue, which is discussed in some detail, especially how it conforms to the mission of the Association of American Colleges and Universities. The editorial ends with some results from a small ad hoc study of Google Scholar Citation Profiles. The question was, of the profiles that used “numeracy” or “quantitative literacy” as keywords, what other keywords did those profiles use, and what were the source countries? The results show that (1 QL is very much an American term, (2 there is, metaphorically, a vast and interesting numeracy ecosystem out there for Numeracy to engage and serve, and (3 as we become more global, the transdisciplinary relevance

  5. Clinicopathologic Characteristics and Outcomes of Histiocytic and Dendritic Cell Neoplasms: The Moffitt Cancer Center Experience Over the Last Twenty Five Years

    Energy Technology Data Exchange (ETDEWEB)

    Dalia, Samir, E-mail: samir.dalia@mercy.net [Mercy Clinic Oncology and Hematology-Joplin, 3001 MC Clelland Park Blvd, Joplin, MO 64804 (United States); Jaglal, Michael; Chervenick, Paul [Department of Malignant Hematology, H. Lee Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33602 (United States); Cualing, Hernani [IHCFLOW Histopathology Laboratory, University of South Florida, 18804 Chaville Rd., Lutz, FL 33558 (United States); Sokol, Lubomir [Department of Malignant Hematology, H. Lee Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33602 (United States)

    2014-11-14

    Neoplasms of histiocytic and dendritic cells are rare disorders of the lymph node and soft tissues. Because of this rarity, the corresponding biology, prognosis and terminologies are still being better defined and hence historically, these disorders pose clinical and diagnostic challenges. These disorders include Langerhans cell histiocytosis (LCH), histiocytic sarcoma (HS), follicular dendritic cell sarcoma (FDCS), interdigtating cell sarcoma (IDCS), indeterminate cell sarcoma (INDCS), and fibroblastic reticular cell tumors (FRCT). In order to gain a better understanding of the biology, diagnosis, and treatment in these rare disorders we reviewed our cases of these neoplasms over the last twenty five years and the pertinent literature in each of these rare neoplasms. Cases of histiocytic and dendritic cell neoplasms diagnosed between 1989–2014 were identified using our institutional database. Thirty two cases were included in this analysis and were comprised of the following: Langerhans cell histiocytosis (20/32), histiocytic sarcoma (6/32), follicular dendritic cell sarcoma (2/32), interdigitating dendritic cell sarcoma (2/32), indeterminate dendritic cell sarcoma (1/32), and fibroblastic reticular cell tumor (1/32). Median overall survival was not reached in cases with LCH and showed 52 months in cases with HS, 12 months in cases with FDCS, 58 months in cases with IDCS, 13 months in the case of INDCS, and 51 months in the case of FRCT. The majority of patients had surgical resection as initial treatment (n = 18). Five patients had recurrent disease. We conclude that histiocytic and dendritic cell neoplasms are very rare and perplexing disorders that should be diagnosed with a combination of judicious morphology review and a battery of immunohistochemistry to rule out mimics such as carcinoma, lymphoma, neuroendocrine tumors and to better sub-classify these difficult to diagnose lesions. The mainstay of treatment for localized disease remains surgical resection

  6. Clinicopathologic Characteristics and Outcomes of Histiocytic and Dendritic Cell Neoplasms: The Moffitt Cancer Center Experience Over the Last Twenty Five Years

    Directory of Open Access Journals (Sweden)

    Samir Dalia

    2014-11-01

    Full Text Available Neoplasms of histiocytic and dendritic cells are rare disorders of the lymph node and soft tissues. Because of this rarity, the corresponding biology, prognosis and terminologies are still being better defined and hence historically, these disorders pose clinical and diagnostic challenges. These disorders include Langerhans cell histiocytosis (LCH, histiocytic sarcoma (HS, follicular dendritic cell sarcoma (FDCS, interdigtating cell sarcoma (IDCS, indeterminate cell sarcoma (INDCS, and fibroblastic reticular cell tumors (FRCT. In order to gain a better understanding of the biology, diagnosis, and treatment in these rare disorders we reviewed our cases of these neoplasms over the last twenty five years and the pertinent literature in each of these rare neoplasms. Cases of histiocytic and dendritic cell neoplasms diagnosed between 1989–2014 were identified using our institutional database. Thirty two cases were included in this analysis and were comprised of the following: Langerhans cell histiocytosis (20/32, histiocytic sarcoma (6/32, follicular dendritic cell sarcoma (2/32, interdigitating dendritic cell sarcoma (2/32, indeterminate dendritic cell sarcoma (1/32, and fibroblastic reticular cell tumor (1/32. Median overall survival was not reached in cases with LCH and showed 52 months in cases with HS, 12 months in cases with FDCS, 58 months in cases with IDCS, 13 months in the case of INDCS, and 51 months in the case of FRCT. The majority of patients had surgical resection as initial treatment (n = 18. Five patients had recurrent disease. We conclude that histiocytic and dendritic cell neoplasms are very rare and perplexing disorders that should be diagnosed with a combination of judicious morphology review and a battery of immunohistochemistry to rule out mimics such as carcinoma, lymphoma, neuroendocrine tumors and to better sub-classify these difficult to diagnose lesions. The mainstay of treatment for localized disease remains surgical

  7. 78 FR 60306 - Big Muddy National Fish and Wildlife Refuge, Authorized Within the Twenty Counties That Lie Along...

    Science.gov (United States)

    2013-10-01

    ... Fish and Wildlife Service Big Muddy National Fish and Wildlife Refuge, Authorized Within the Twenty... availability of a draft environmental assessment (EA) and comprehensive conservation plan (CCP) for Big Muddy... one of the following methods: Email: [email protected] . Include ``Big Muddy Draft EA/ CCP'' in the...

  8. Essential Soft Skills for Success in the Twenty-First Century Workforce as Perceived by Business Educators

    Science.gov (United States)

    Mitchell, Geana W.; Skinner, Leane B.; White, Bonnie J.

    2010-01-01

    Background: Soft skills describe career attributes that individuals should possess, such as team skills, communication skills, ethics, time-management skills, and an appreciation for diversity. In the twenty-first century workforce, soft skills are important in every business sector. However, employers in business continuously report that new…

  9. Multilingual domain modeling in Twenty-One: automatic creation of a bi-directional translation lexicon from a parallel corpus

    NARCIS (Netherlands)

    Hiemstra, Djoerd

    1998-01-01

    Within the project Twenty-One, which aims at the effective dissemination of information on ecology and sustainable development, a sytem is developed that supports cross-language information retrieval in any of the four languages Dutch, English, French and German. Knowledge of this application domain

  10. The Twenty-First Century and Legal Studies in Business: Preparing Students to Perform in a Globally Competitive Environment

    Science.gov (United States)

    Burke, Debra D.; Johnson, Ronald A.; Kemp, Deborah J.

    2010-01-01

    This article first examines the dynamic role business education must play in a flat world economy. Second, it explains how legal courses in the business curricula already equip students with portable twenty-first-century skills and relevant academic content. The article then advocates the acceptance of the Boyer Model of Scholarship, which defines…

  11. From School to Cafe and Back Again: Responding to the Learning Demands of the Twenty-First Century

    Science.gov (United States)

    McWilliam, Erica

    2011-01-01

    This paper traces the historical origins of formal and informal lifelong learning to argue that optimal twenty-first-century education can and should draw on the traditions of both the school and the coffee house or cafe. For some time now, educational policy documents and glossy school brochures have come wrapped in the mantle of lifelong…

  12. Insights into Finnish First-Year Pre-Service Teachers' Twenty-First Century Skills

    Science.gov (United States)

    Valtonen, Teemu; Sointu, Erkko Tapio; Kukkonen, Jari; Häkkinen, Päivi; Järvelä, Sanna; Ahonen, Arto; Näykki, Piia; Pöysä-Tarhonen, Johanna; Mäkitalo-Siegl, Kati

    2017-01-01

    This study focuses on Finnish pre-service teachers' perceptions of their twenty-first century skills, especially their learning strategies, collaboration and teamwork, as well as knowledge and attitudes related to ICT in education. The target group consist of 263 first-year pre-service teachers from three universities. The results outline how…

  13. Twenty years of experience with central softening in The Netherlands : Water quality – Environmental benefits – Costs

    NARCIS (Netherlands)

    Hofman, J.A.M.H.; Kramer, O.J.I.; van der Hoek, J.P.; Nederlof, M; Groenendijk, M

    2006-01-01

    Central softening has been utilized by the Dutch water utilities since the late 1970s. It was introduced in the water treatment process as a method to supply water with an optimum water composition to prevent lead and copper release and to prevent excessive scaling. Twenty years of experience show

  14. Sea-level rise and its possible impacts given a 'beyond 4.C world' in the twenty-first century

    NARCIS (Netherlands)

    Nicholls, R.J.; Marinova, N.; Lowe, J.A.; Brown, S.; Vellinga, P.; de Gusmão, D.; Hinkel, J.; Tol, R.S.J.

    2011-01-01

    The range of future climate-induced sea-level rise remains highly uncertain with continued concern that large increases in the twenty-first century cannot be ruled out. The biggest source of uncertainty is the response of the large ice sheets of Greenland and west Antarctica. Based on our analysis,

  15. Professional Capabilities for Twenty-First Century Creative Careers: Lessons from Outstandingly Successful Australian Artists and Designers

    Science.gov (United States)

    Bridgstock, Ruth

    2013-01-01

    Artists and designers are positioned at the centre of the twenty-first century creative economy. In order to recognise and make the most of the opportunities afforded by this new era, artists and designers still require the creativity, disciplinary depth of knowledge and technical skills traditionally possessed by professionals in these…

  16. How Disability and School-Related Variables Influence Social Security Dependence among Vulnerable Young People in Their Late Twenties

    Science.gov (United States)

    Myklebust, Jon Olav

    2015-01-01

    The objective of this article is to investigate how psychosocial difficulties, functional level and school factors affect social security dependence among former students with special needs (N = 373). These individuals have been followed prospectively from their teens and into their late twenties. The study is theoretically inspired by life-course…

  17. "Helping Communities To Help Themselves." Twenty 1989 Exemplary Prevention Programs for Preventing Alcohol and Other Drug Abuse. Project Summaries.

    Science.gov (United States)

    National Association of State Alcohol and Drug Abuse Directors, Inc.

    Twenty exemplary substance abuse prevention programs are presented in this document. These programs are included: (1) Tuba City, Arizona, Fetal Alcohol Syndrome (FAS) Prevention Program; (2) Chemical Addiction Course, University of Arkansas; (3) "Teens Are Concerned" of Arkansas; (4) "Dare to be You of Colorado"; (5) Winyan…

  18. Twenty-First Century Instructional Classroom Practices and Reading Motivation: Probing the Effectiveness of Interventional Reading Programs

    Science.gov (United States)

    Boulhrir, Taoufik

    2017-01-01

    Twenty-first century education has undoubtedly witnessed changes of the definition of literacy to cope with the economic, social, and intellectual trends. Technological advances, which include skills of communication, creativity, critical thinking, and collaboration have become key in education, especially when dealing with literacy and reading…

  19. Index to the Twenty-first Semiannual Report of the Commission to the Congress. July 1956 - December 1956

    Energy Technology Data Exchange (ETDEWEB)

    Strauss, Lewis L.

    1957-01-31

    This volume contains a name and subject indext for the twenty-first semiannual report of the United States Atomic Energy Commission to Congress. The full semiannual report covers the major unclassified activities of the Commission from July 1956 through December 1956.

  20. Science Teacher Education in the Twenty-First Century: a Pedagogical Framework for Technology-Integrated Social Constructivism

    Science.gov (United States)

    Barak, Miri

    2017-04-01

    Changes in our global world have shifted the skill demands from acquisition of structured knowledge to mastery of skills, often referred to as twenty-first century competencies. Given these changes, a sequential explanatory mixed methods study was undertaken to (a) examine predominant instructional methods and technologies used by teacher educators, (b) identify attributes for learning and teaching in the twenty-first century, and (c) develop a pedagogical framework for promoting meaningful usage of advanced technologies. Quantitative and qualitative data were collected via an online survey, personal interviews, and written reflections with science teacher educators and student teachers. Findings indicated that teacher educators do not provide sufficient models for the promotion of reform-based practice via web 2.0 environments, such as Wikis, blogs, social networks, or other cloud technologies. Findings also indicated four attributes for teaching and learning in the twenty-first century: (a) adapting to frequent changes and uncertain situations, (b) collaborating and communicating in decentralized environments, (c) generating data and managing information, and (d) releasing control by encouraging exploration. Guided by social constructivist paradigms and twenty-first century teaching attributes, this study suggests a pedagogical framework for fostering meaningful usage of advanced technologies in science teacher education courses.

  1. Nonlinear Pedagogy and Its Role in Encouraging Twenty-First Century Competencies through Physical Education: A Singapore Experience

    Science.gov (United States)

    Lee, Miriam Chang Yi; Chow, Jia Yi; Button, Chris; Tan, Clara Wee Keat

    2017-01-01

    Nonlinear Pedagogy is an exploratory approach to teaching and learning Physical Education that can be potentially effective to help children acquire relevant twenty-first century competencies. Underpinned by Ecological Dynamics, the focus of Nonlinear Pedagogy is on the learner and includes the provision of less prescriptive instructions and…

  2. Rethinking Teaching and Learning Pedagogy for Education in the Twenty-First Century: Blended Learning in Music Education

    Science.gov (United States)

    Crawford, Renée

    2017-01-01

    In an increasingly technologically driven world, there is proliferate discussion among education and government authorities about the necessity to rethink education in the twenty-first century. The evolution of technology and its pervasive influence on the needs and requirements of society is central to this mindset. Innovations in online…

  3. Predicting climate change impacts on native and invasive tree species using radial growth and twenty-first century climate scenarios

    NARCIS (Netherlands)

    González-Muñoz, N.; Linares, J.C.; Castro-Díez, P.; Sass-Klaassen, U.G.W.

    2014-01-01

    The climatic conditions predicted for the twenty-first century may aggravate the extent and impacts of plant invasions, by favouring those invaders more adapted to altered conditions or by hampering the native flora. We aim to predict the fate of native and invasive tree species in the oak forests

  4. Teaching and Learning for the Twenty-First Century: Educational Goals, Policies, and Curricula from Six Nations

    Science.gov (United States)

    Reimers, Fernando M., Ed.; Chung, Connie K., Ed.

    2016-01-01

    This book describes how different nations have defined the core competencies and skills that young people will need in order to thrive in the twenty-first-century, and how those nations have fashioned educational policies and curricula meant to promote those skills. The book examines six countries--Chile, China, India, Mexico, Singapore, and the…

  5. Imagination in Twenty-First Century Teaching and Learning Teachers as Creative-Adaptive Leaders in the Classroom

    Science.gov (United States)

    Dias, Shamini Samanlatha Elizabeth

    2013-01-01

    This dissertation explored the value and functions of imagination in leading learning in the twenty-first century, a knowledge-based age marked by diversity, change and unpredictability. In such a context, how can imagination enable teachers to be leaders of learning who optimally engage and prepare students for success? Research in cognitive…

  6. The twenty-second screening for thyroid disorders in radiation-contaminated areas of the Ukraine

    Energy Technology Data Exchange (ETDEWEB)

    Harada, Tanekazu [Kawasaki Coll. of Allied Health Professions, Kurashiki, Okayama (Japan); Monobe, Manami

    2000-12-01

    One hundred and ninety-one people who reside in radiation-contaminated areas of the Ukraine near the site of the Chernobyl nuclear plant accident were screened in 1999. The ages of people screened ranged from 1 to 74 years. Diffuse goiter was palpable in 67.5%, and nodular goiter in 3.1%. Thyroid cancer was detected in only one suspicious case. Among the people with diffuse goiter, however, there were positive anti-thyroglobulin hemagglutination tests (TGHA) in 6.7% and positive anti-microsome hemagglutination tests (MCHA) in 16.7% of cases. In addition, urinary iodine concentrations and daily urinary excretion were low. Thus, it is thought that the majority of diffuse goiters in this area are not due to autoimmune thyroiditis but to iodine deficiency. At present, no definite conclusion can be drawn on the relationship between the large number of diffuse goiters and radioactive contamination. Further studies are required. (author)

  7. Twenty-Four Hour Structure of Vigilance under Prolonged Sleep Deprivation: Relationship with Performance

    Science.gov (United States)

    1986-03-01

    ost estudies have acjr-eed that ther-e ar-e at leatst two types o-f fluct~uatil-IS inr vigil atcei cit-cadl an r-hythms Iiti the ordcer- oF 24hi, arid...performance. The fact, however, that In some cases the swi ichaver in performance actually preceded the sle~ep gate, mvAkes this e~cpiaraýiajin

  8. STAR 21, Technology Forecast Assessments. Strategic Technologies for the Army of the Twenty-First Century

    Science.gov (United States)

    1993-01-01

    Data base management system DEW Directed energy weapon DIAL Differential-absorption LIDAR DNA Deoxyribonucleic acid DOD Department of Defense DRAM...inside cells. As knowledge of specific genes and their interactions increases, the techniques of recombinant DNA , cell fusion, and gene splicing will...like grasshoppers , combining mobility and the radio computer pyro electric shot weapo battery case trip wire microphone FIGURE 9-1 The $19.95

  9. Conditioning of cooling water in power stations. Feedback from twenty years of experience with acid feeding

    Energy Technology Data Exchange (ETDEWEB)

    Goffin, C.; Duvivier, L.; Girasa, E. [LABORELEC, Chemistry of Water (Belgium); Brognez, J. [ELECTRABEL, TIHANGE Nuclear Power Station (Belgium)

    2002-07-01

    solution is no longer easily justifiable. The research efforts undertaken to better understand and control calcium carbonate precipitation and scale formation have paid off and have resulted in the standardisation of the treatment process and the control procedure of the cooling circuits by ELECTRABEL. The initial experience gained in the fossil power plants of AMERCOEUR (2 x 125 MW units) was finally successfully applied to plants 2 and 3 at TIHANGE. Since then, all of the conventional or combined cycle power plants have adopted the same treatment philosophy. Six units of between 125 and 1000 MW have been treated in this manner, some of them for over twenty years, without showing any signs of scale deposits. It is true that adaptations have had to be made in the control recommendations defined during the pilot trials, in order to allow for the impact of cathodic protections and certain cooling tower fills. (authors)

  10. An Urethral Stone Mimicking Urinary Tract Infection in a Twenty-six-month-old Boy

    Directory of Open Access Journals (Sweden)

    Mehmet Giray Sönmez

    2015-12-01

    Full Text Available A 26-month-old boy, who was misdiagnosed with urinary tract infection, was admitted to our hospital with increasing complaints of uneasiness, vomiting and nausea. On physical examination, a urethral stone was suspected and was confirmed by plain urinary tract x-ray. In children, the clinical features of a urethral stone may be overlooked because children are not able to express their complaints fully. Therefore, a detailed and careful physical examination is of great importance. In this paper, we present the rare case of urethral stone in a child and a review of the literature.

  11. Twenty-nine-month follow-up of a paediatric zirconia dental crown.

    Science.gov (United States)

    Lopez Cazaux, Serena; Hyon, Isabelle; Prud'homme, Tony; Dajean Trutaud, Sylvie

    2017-06-14

    The aim of this paper is to present the long-term follow-up of one paediatric zirconia crown on a deciduous molar. Preformed crowns are part of the armamentarium in paediatric dentistry. In recent years, aesthetic alternatives to preformed metal crowns have been developed, first preveneered crowns and then zirconia crowns. This paper describes the restoration of a primary molar with a zirconia crown (EZ-Pedo, Loomis, California, USA) in an 8-year-old boy. In this clinical case, the protocol for the implementation and maintenance of zirconia crowns is detailed. The patient was followed up for 29 months until the natural exfoliation of his primary molar. The adaptation of the zirconia crown, the gingival health and the wear on the opposing tooth were considered. In this case, the paediatric zirconia crown allowed sustainable functional restoration while restoring a natural appearance of the tooth. © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  12. Twenty years of Hendra virus: laboratory submission trends and risk factors for infection in horses.

    Science.gov (United States)

    Smith, C S; McLAUGHLIN, A; Field, H E; Edson, D; Mayer, D; Ossedryver, S; Barrett, J; Waltisbuhl, D

    2016-11-01

    Hendra virus (HeV) was first described in 1994 in an outbreak of acute and highly lethal disease in horses and humans in Australia. Equine cases continue to be diagnosed periodically, yet the predisposing factors for infection remain unclear. We undertook an analysis of equine submissions tested for HeV by the Queensland government veterinary reference laboratory over a 20-year period to identify and investigate any patterns. We found a marked increase in testing from July 2008, primarily reflecting a broadening of the HeV clinical case definition. Peaks in submissions for testing, and visitations to the Government HeV website, were associated with reported equine incidents. Significantly differing between-year HeV detection rates in north and south Queensland suggest a fundamental difference in risk exposure between the two regions. The statistical association between HeV detection and stockhorse type may suggest that husbandry is a more important risk determinant than breed per se. The detection of HeV in horses with neither neurological nor respiratory signs poses a risk management challenge for attending veterinarians and laboratory staff, reinforcing animal health authority recommendations that appropriate risk management strategies be employed for all sick horses, and by anyone handling sick horses or associated biological samples.

  13. Insulin edema in the twenty-first century: review of the existing literature.

    Science.gov (United States)

    Chelliah, Aruna; Burge, Mark R

    2004-03-01

    Generalized insulin edema, although rare, is a well-recognized complication of insulin therapy. It is mainly appreciated in patients with newly diagnosed or poorly controlled diabetes mellitus after starting intensive insulin therapy. Although the condition is self-limiting, progression to overt cardiac failure and development of pleural effusion have been reported. With current trends toward intensive insulin therapy, clinicians should be aware of the existence of the insulin edema syndrome, and its occurrence should be documented and differentiated from other causes of edema. In this article, we present a recent case that illustrates the clinical features of insulin edema. Specifically, a young male with newly diagnosed type 1 diabetes mellitus developed significant, reversible peripheral edema after starting insulin therapy. A detailed case description is accompanied by the only known published photographs of insulin edema. The overall purpose of this article is to review the scanty existing medical literature surrounding the topic of insulin edema and to raise awareness about its continued occurrence.

  14. Bosnia-Herzegovina case study

    OpenAIRE

    Wise, Laura

    2017-01-01

    During the war in Bosnia-Herzegovina from 1992-1995, issues of inclusion and protection of ethno-national groups were key sticking points throughout the peace process. Over twenty years since the Dayton Peace Agreement was signed in 1995, questions of equality and stability continue to challenge attempts to reform Bosnia-Herzegovina’s institutional configuration. This case study traces how ethno-national group inclusion was negotiated both during and after the peace process, and how the compl...

  15. Medical Cosmopolitanism in Global Dubai: A Twenty-first-century Transnational Intracytoplasmic Sperm Injection (ICSI) Depot.

    Science.gov (United States)

    Inhorn, Marcia C

    2017-03-01

    Dubai-one of the seven United Arab Emirates and the Middle East's only "global city"-is gaining a reputation as a transnational medical tourism hub. Characterized by its "medical cosmopolitanism," Dubai is now attracting medical travelers from around the world, some of whom are seeking assisted conception. Dubai is fast becoming known as a new transnational "reprohub" for intracytoplasmic sperm injection (ICSI), the variant of in vitro fertilization designed to overcome male infertility. Based on ethnographic research conducted in one of the country's most cosmopolitan clinics, this article explores the ICSI treatment quests of infertile men coming to Dubai from scores of other nations. The case of an infertile British-Moroccan man is highlighted to demonstrate why ICSI is a particularly compelling "masculine hope technology" for infertile Muslim men. Thus, Muslim men who face barriers to ICSI access in their home countries may become "reprotravelers" to Dubai, an emergent ICSI depot. © 2016 by the American Anthropological Association.

  16. A retrospective analysis of twenty-eight borderline ovarian tumours in adolescent girls.

    Science.gov (United States)

    Tsikouras, P; Liberis, V; Galazios, G; Panagiotidou, C; Bouchlariotou, S; Teichmann, A T; Maroulis, G

    2009-01-01

    The aim of this retrospective study was to evaluate the clinical reproductive outcome and the rate of recurrence of low malignant ovarian tumors in adolescent girls after conservative surgical treatment by laparoscopy or laparotomy. We report 28 cases of borderline ovarian tumors (BOTs), that were surgically treated from 1990 to 2006 at the Obstetrical and Gynecological Department of Democritus University in Greece and the Aschaffenburg Teaching Hospital in Germany. All patient information was obtained by reviewing hospital records. BOT lesions in teenagers were associated with variable non-specific presenting symptoms. Ultrasonographic investigations can be helpful in the early diagnosis of BOTs in teenage girls. Most of the patients were diagnosed at an early stage. Available data of our study indicate that in these patients, fertility, pregnancy outcome and survival remain excellent.

  17. Twenty years of experience with corrosion failures caused by manganese oxidizing microorganisms

    Energy Technology Data Exchange (ETDEWEB)

    Linhardt, P. [Institute for Chemical Technologies and Analytics, Vienna University of Technology, Getreidemarkt 9/164, 1060 Vienna (Austria)

    2010-12-15

    Manganese oxidizing microorganisms are known as ubiquitous species in soil and fresh water. Their ability to extract dissolved manganese even at minute concentrations from the water and to biomineralize it as manganese(III/IV)oxides makes them potentially relevant for corrosion processes in technical systems carrying freshwater. These oxides are known as strong oxidants and may act as catalyst for the oxygen reduction reaction. Thus, they are cathodically active, possibly driving anodic metal dissolution processes. The personal experiences over two decades from failure analysis related to these organisms have indeed shown that manganese oxidizers may appear in all kinds of freshwater systems. This paper summarizes observations and conclusions drawn from these cases and provides an overview on the methods found useful in their investigation. (Copyright copyright 2010 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  18. Transnational Circulations of "Laban" Methods: Gender, Power Relations, and Negotiated Meanings in Early Twenty-First Century South Korea's Modernity

    OpenAIRE

    Hwang, Hye-Won

    2013-01-01

    This dissertation investigates western-developed "Laban" methods that middle-class Korean female Laban specialists transported to South Korea and, there, tactically adapted to South Korean contexts during the 1990s and the early twenty-first century. It particularly focuses on how these Korean women's repurposings of "Laban" methods intersect with conditions of global capitalism and specific South Korean cultural politics, job markets, and dance instruction and employment networks. I claim th...

  19. Building Interdisciplinary Leadership Skills among Health Practitioners in the Twenty-First Century: An Innovative Training Model

    OpenAIRE

    Negandhi, Preeti; Negandhi, Himanshu; Tiwari, Ritika; Sharma, Kavya; Zodpey, Sanjay P; Quazi, Zahiruddin; Gaidhane, Abhay; Jayalakshmi N.,; Gijare, Meenakshi; Yeravdekar, Rajiv

    2015-01-01

    Transformational learning is the focus of twenty-first century global educational reforms. In India, there is a need to amalgamate the skills and knowledge of medical, nursing, and public health practitioners and to develop robust leadership competencies among them. This initiative proposed to identify interdisciplinary leadership competencies among Indian health practitioners and to develop a training program for interdisciplinary leadership skills through an Innovation Collaborative. Medica...

  20. Detached concern?: Emotional socialization in twenty-first century medical education.

    Science.gov (United States)

    Underman, Kelly; Hirshfield, Laura E

    2016-07-01

    Early works in medical sociology have been pivotal in the development of scholarly knowledge about emotions, emotional socialization, and empathy within medical training, medical education, and medical contexts. Yet despite major shifts in both medical education and in medicine writ-large, medical sociologists' focus on emotions has largely disappeared. In this paper, we argue that due to recent radical transformations in the medical arena, emotional socialization within medical education should be of renewed interest for sociologists. Developments in medical education such as increased diversity among enrollees, the rise of patient health movements, and curricular transformation have made this context a particularly interesting case for sociologists working on a variety of questions related to structural, organizational, and cultural change. We offer three areas of debate within studies in medical education that sociologists may be interested in studying: 1) gendered and racialized differences in the performance of clinical skills related to emotion, 2) differences in self-reported empathy among subspecialties, and 3) loss of empathy during the third year or clinical year of medical school. Copyright © 2016 Elsevier Ltd. All rights reserved.

  1. Twenty Years After Genocide: The Role of Psychology in the Reconciliation and Reconstruction Process in Rwanda

    Directory of Open Access Journals (Sweden)

    Craig McGarty

    2014-12-01

    Full Text Available This Special Thematic Section brings together eight papers that showcase different aspects of the contribution of psychology to the processes of recovery in Rwanda following the 1994 genocide. The Section is noteworthy in part because a majority of the papers have Rwandan authors. In summarizing the contributions I make six observations about the remarkable context of the genocide and its aftermath: a it was distinctive from previous mass violence in its intensity and character; b it has been characterized by bystander inaction and the problems of positioning outsiders to help; c hundreds of thousands of accused or convicted perpetrators have lived alongside survivors; d electronic media played a profound role not only in promoting violence but also in building peace; e Rwanda has been the site of unprecedented societal interventions with political goals that have the character and content of social psychological experiments; and f the role of memorialization in repairing or sustaining harm needs further examination. I conclude by noting that the study of recovery is clear proof that the genocide in Rwanda, as is the case with genocides of the past, failed to achieve its aims.

  2. Twenty year experience of the oral rabies vaccine SAG2 in wildlife: a global review.

    Science.gov (United States)

    Mähl, Philippe; Cliquet, Florence; Guiot, Anne-Laure; Niin, Enel; Fournials, Emma; Saint-Jean, Nathalie; Aubert, Michel; Rupprecht, Charles E; Gueguen, Sylvie

    2014-08-10

    The SAG2 vaccine (RABIGEN® SAG2) is a modified live attenuated rabies virus vaccine, selected from the SAD Bern strain in a two-step process of amino acid mutation using neutralizing monoclonal antibodies. The strain is genetically stable and does not spread in vivo or induce a persistent infection. Its absence of residual pathogenicity was extensively demonstrated in multiple target and non target species (such as wild carnivores and rodent species), including non-human primates. The efficacy of SAG2 baits was demonstrated according to the EU requirements for the red fox and raccoon dog. The use of safe and potent rabies vaccines such as SAG2 largely contributed to the elimination of rabies in Estonia, France, Italy and Switzerland. Importantly, these countries were declared free of rabies after few years of oral vaccination campaigns with SAG2 baits distributed with an appropriate strategy. The excellent tolerance of the SAG2 vaccine has been confirmed in the field since its first use in 1993. No safety issues have been reported, and in particular no vaccine-induced rabies cases were diagnosed, after the distribution of more than 20 million SAG2 baits in Europe.

  3. [Therapeutic drug monitoring of three antiepileptic drugs - Back on twenty years of experience].

    Science.gov (United States)

    Serragui, Samira; Zalagh, Fatima; Tanani, Driss Soussi; Ouammi, Lahcen; Moussa, Latifa Ait; Badrane, Narjis; Bencheikh, Rachida Soulaymani

    2016-01-01

    The therapeutic drug monitoring (TDM) of antiepileptic drugs is a tool widely used in the management of epilepsy. In Morocco, this monitoring is carried out by the Centre Anti Poison et Pharmacovigilance (CAPM) since April 1995. This is a retrospective study spanning 20 years. It concerns the therapeutic drug monitoring of Phenobarbital (PB) of carbamazepine (CBZ) and valproic acid (VPA). Therapeutic drug monitoring of the 3 antiepileptic drugs represent 58.85% of all applications received by the CAPM. The dosage of PB was ranked first followed by that of CBZ and finally by the VPA. Weak demand for therapeutic drug monitoring in Morocco could be explained by the low number of neurologists in addition to social factors. With its affordable price by patients, PB is the most prescribed antiepileptic drug in our country, which explains the high demand for its dosage. As for the therapeutic drug monitoring of the antiepileptic drug, they were mainly related to age, the occurrence of adverse effects, the association antiepileptic drugs or in the case of verification of patient compliance. Efforts are required for promoting the interests of therapeutic drug monitoring of antiepileptic drug in the management of epilepsy in Morocco.

  4. Twenty years of vasoplegic syndrome treatment in heart surgery. Methylene blue revised

    Directory of Open Access Journals (Sweden)

    Paulo Roberto Barbosa Evora

    2015-02-01

    Full Text Available Objective: This study was conducted to reassess the concepts established over the past 20 years, in particular in the last 5 years, about the use of methylene blue in the treatment of vasoplegic syndrome in cardiac surgery. Methods: A wide literature review was carried out using the data extracted from: MEDLINE, SCOPUS and ISI WEB OF SCIENCE. Results: The reassessed and reaffirmed concepts were 1 MB is safe in the recommended doses (the lethal dose is 40 mg/kg; 2 MB does not cause endothelial dysfunction; 3 The MB effect appears in cases of NO up-regulation; 4 MB is not a vasoconstrictor, by blocking the cGMP pathway it releases the cAMP pathway, facilitating the norepinephrine vasoconstrictor effect; 5 The most used dosage is 2 mg/kg as IV bolus, followed by the same continuous infusion because plasma concentrations sharply decrease in the first 40 minutes; and 6 There is a possible "window of opportunity" for MB's effectiveness. In the last five years, major challenges were: 1 Observations about side effects; 2 The need for prophylactic and therapeutic guidelines, and; 3 The need for the establishment of the MB therapeutic window in humans. Conclusion: MB action to treat vasoplegic syndrome is time-dependent. Therefore, the great challenge is the need, for the establishment the MB therapeutic window in humans. This would be the first step towards a systematic guideline to be followed by possible multicenter studies.

  5. Nontuberculous Mycobacteria Isolation from Clinical and Environmental Samples in Iran: Twenty Years of Surveillance

    Directory of Open Access Journals (Sweden)

    Ali Akbar Velayati

    2015-01-01

    Full Text Available Nontuberculous mycobacteria (NTM are opportunistic pathogens that are widely distributed in the environment. There is a lack of data on species distribution of these organisms from Iran. This study consists of a review of NTM articles published in Iran between the years 1992 and 2014. In this review, 20 articles and 14 case reports were identified. Among the 20 articles, 13 (65% studies focused on NTM isolates from clinical specimens, 6 (30% studies examined NTM isolates from environmental samples, and one (5% article included both clinical and environmental isolates. M. fortuitum (229/997; 23% was recorded as the most prevalent and rapid growing mycobacteria (RGM species in both clinical (28% and environmental (19% isolated samples (P < 0.05. Among slow growing mycobacteria (SGM, M. simiae (103/494; 21% demonstrated a higher frequency in clinical samples whereas in environmental samples it was M. flavescens (44/503; 9%. These data represent information from 14 provinces out of 31 provinces of Iran. No information is available in current published data on clinical or environmental NTM from the remaining 17 provinces in Iran. These results emphasize the potential importance of NTM as well as the underestimation of NTM frequency in Iran. NTM is an important clinical problem associated with significant morbidity and mortality in Iran. Continued research is needed from both clinical and environmental sources to help clinicians and researchers better understand and address NTM treatment and prevention.

  6. Nontuberculous Mycobacteria Isolation from Clinical and Environmental Samples in Iran: Twenty Years of Surveillance.

    Science.gov (United States)

    Velayati, Ali Akbar; Farnia, Parissa; Mozafari, Mohadese; Mirsaeidi, Mehdi

    2015-01-01

    Nontuberculous mycobacteria (NTM) are opportunistic pathogens that are widely distributed in the environment. There is a lack of data on species distribution of these organisms from Iran. This study consists of a review of NTM articles published in Iran between the years 1992 and 2014. In this review, 20 articles and 14 case reports were identified. Among the 20 articles, 13 (65%) studies focused on NTM isolates from clinical specimens, 6 (30%) studies examined NTM isolates from environmental samples, and one (5%) article included both clinical and environmental isolates. M. fortuitum (229/997; 23%) was recorded as the most prevalent and rapid growing mycobacteria (RGM) species in both clinical (28%) and environmental (19%) isolated samples (P mycobacteria (SGM), M. simiae (103/494; 21%) demonstrated a higher frequency in clinical samples whereas in environmental samples it was M. flavescens (44/503; 9%). These data represent information from 14 provinces out of 31 provinces of Iran. No information is available in current published data on clinical or environmental NTM from the remaining 17 provinces in Iran. These results emphasize the potential importance of NTM as well as the underestimation of NTM frequency in Iran. NTM is an important clinical problem associated with significant morbidity and mortality in Iran. Continued research is needed from both clinical and environmental sources to help clinicians and researchers better understand and address NTM treatment and prevention.

  7. Sustaining Research Networks: the Twenty-Year Experience of the HMO Research Network.

    Science.gov (United States)

    Steiner, John F; Paolino, Andrea R; Thompson, Ella E; Larson, Eric B

    2014-01-01

    As multi-institutional research networks assume a central role in clinical research, they must address the challenge of sustainability. Despite its importance, the concept of network sustainability has received little attention in the literature, and the sustainability strategies of durable scientific networks have not been described. The Health Maintenance Organization Research Network (HMORN) is a consortium of 18 research departments in integrated health care delivery systems with over 15 million members in the United States and Israel. The HMORN has coordinated federally funded scientific networks and studies since 1994. This case study describes the HMORN approach to sustainability, proposes an operational definition of network sustainability, and identifies 10 essential elements that can enhance sustainability. The sustainability framework proposed here is drawn from prior publications on organizational issues by HMORN investigators and from the experience of recent HMORN leaders and senior staff. Network sustainability can be defined as (1) the development and enhancement of shared research assets to facilitate a sequence of research studies in a specific content area or multiple areas, and (2) a community of researchers and other stakeholders who reuse and develop those assets. Essential elements needed to develop the shared assets of a network include: network governance; trustworthy data and processes for sharing data; shared knowledge about research tools; administrative efficiency; physical infrastructure; and infrastructure funding. The community of researchers within a network is enhanced by: a clearly defined mission, vision and values; protection of human subjects; a culture of collaboration; and strong relationships with host organizations. While the importance of these elements varies based on the membership and goals of a network, this framework for sustainability can enhance strategic planning within the network and can guide relationships with

  8. Twenty-five years of confirmatory adaptive designs: opportunities and pitfalls.

    Science.gov (United States)

    Bauer, Peter; Bretz, Frank; Dragalin, Vladimir; König, Franz; Wassmer, Gernot

    2016-02-10

    'Multistage testing with adaptive designs' was the title of an article by Peter Bauer that appeared 1989 in the German journal Biometrie und Informatik in Medizin und Biologie. The journal does not exist anymore but the methodology found widespread interest in the scientific community over the past 25 years. The use of such multistage adaptive designs raised many controversial discussions from the beginning on, especially after the publication by Bauer and Köhne 1994 in Biometrics: Broad enthusiasm about potential applications of such designs faced critical positions regarding their statistical efficiency. Despite, or possibly because of, this controversy, the methodology and its areas of applications grew steadily over the years, with significant contributions from statisticians working in academia, industry and agencies around the world. In the meantime, such type of adaptive designs have become the subject of two major regulatory guidance documents in the US and Europe and the field is still evolving. Developments are particularly noteworthy in the most important applications of adaptive designs, including sample size reassessment, treatment selection procedures, and population enrichment designs. In this article, we summarize the developments over the past 25 years from different perspectives. We provide a historical overview of the early days, review the key methodological concepts and summarize regulatory and industry perspectives on such designs. Then, we illustrate the application of adaptive designs with three case studies, including unblinded sample size reassessment, adaptive treatment selection, and adaptive endpoint selection. We also discuss the availability of software for evaluating and performing such designs. We conclude with a critical review of how expectations from the beginning were fulfilled, and - if not - discuss potential reasons why this did not happen. © 2015 The Authors. Statistics in Medicine Published by John Wiley & Sons Ltd.

  9. Twenty years of multidisciplinary research and practice: the Journal of Occupational Rehabilitation then and now.

    Science.gov (United States)

    Shaw, William S; Findley, Patricia A; Feuerstein, Michael

    2011-12-01

    Early research of work disability in the 1980s showed a complexity of factors influencing pain and health-related functional limitation at work; hence, multidisciplinary perspectives were necessary to understand the complex interplay between biomechanical, organizational, social, and psychological factors impacting work disability. To address this need, the Journal of Occupational Rehabilitation was founded in 1991 with the goal of providing a scientific, yet practical forum for presenting multidisciplinary research and practice in work disability. Now, the 20-year collection of articles in the Journal reflects important trends and directions in the field of occupational rehabilitation. We conducted a retrospective summary of the past 20 years of the Journal of Occupational Rehabilitation, including its inaugural goals and intent, rates of submission and acceptance, trends in the types of articles published, study topics, global distribution of authors, and future directions. The original goal of providing a multidisciplinary scientific and practical forum has been met, but current trends reflect a maturing scientific evidence base, with less representation of employer-based case studies and practical innovations. There has been a dramatic increase in the international representation of studies, authors, and peer reviewers outside of the US. Also, published studies now address work disability for a larger number of health concerns. Contributions to the Journal continue to reflect a multidisciplinary perspective, but the Journal has seen significant changes with respect to international representation, the expanding study of non-musculoskeletal sources of work disability, and the maturing scientific evidence base in the field of occupational rehabilitation. Future volumes of the Journal will likely reflect continuing changes in the global economy, workforce fitness, and job demands.

  10. The Observed State of the Water Cycle in the Early Twenty-First Century

    Science.gov (United States)

    Rodell, M.; Beaudoing, H. K.; L'Ecuyer, T. S.; Olson, W. S.; Famiglietti, J. S.; Houser, P. R.; Adler, R.; Bosilovich, M. G.; Clayson, C. A.; Chambers, D.; hide

    2015-01-01

    This study quantifies mean annual and monthly fluxes of Earth's water cycle over continents and ocean basins during the first decade of the millennium. To the extent possible, the flux estimates are based on satellite measurements first and data-integrating models second. A careful accounting of uncertainty in the estimates is included. It is applied within a routine that enforces multiple water and energy budget constraints simultaneously in a variational framework in order to produce objectively determined optimized flux estimates. In the majority of cases, the observed annual surface and atmospheric water budgets over the continents and oceans close with much less than 10% residual. Observed residuals and optimized uncertainty estimates are considerably larger for monthly surface and atmospheric water budget closure, often nearing or exceeding 20% in North America, Eurasia, Australia and neighboring islands, and the Arctic and South Atlantic Oceans. The residuals in South America and Africa tend to be smaller, possibly because cold land processes are negligible. Fluxes were poorly observed over the Arctic Ocean, certain seas, Antarctica, and the Australasian and Indonesian islands, leading to reliance on atmospheric analysis estimates. Many of the satellite systems that contributed data have been or will soon be lost or replaced. Models that integrate ground-based and remote observations will be critical for ameliorating gaps and discontinuities in the data records caused by these transitions. Continued development of such models is essential for maximizing the value of the observations. Next-generation observing systems are the best hope for significantly improving global water budget accounting.

  11. Twenty-Three New Ultracool Subdwarfs from the Sloan Digital Sky Survey

    Science.gov (United States)

    Lépine, Sébastien; Scholz, Ralf-Dieter

    2008-07-01

    A search of the Sloan Digital Sky Survey spectroscopic database has turned up 23 new ultracool subdwarfs, low-mass metal-poor stars of spectral subtype M 7.0 or later. Spectra from these red objects all show very strong molecular bands of CaH but relatively weak bands of TiO, indicative of a cool, metal-poor atmosphere. Five of the stars are formally classified as M subdwarfs (sdM7.0-sdM8.5), 13 as more metal-poor extreme subdwarfs (esdM7.0-esdM8.0), and five as extremely metal-poor ultra subdwarfs (usdM7.0-usdM7.5). In the [Hr, r - z] reduced proper motion diagram, these subdwarfs clearly populate the locus of low-luminosity stars with halo kinematics. It is argued that the objects are all very low mass, metal-poor stars from the Galactic halo (Population II). These new discoveries more than double the census of spectroscopically confirmed ultracool subdwarfs. We show that the stars stand out remarkably in the [g - r, r - i] color-color diagram; a proposed color and proper motion selection scheme is expected to be extremely efficient in identifying more of these old, very low mass stars in the vicinity of the Sun. The SDSS is managed by the Astrophysical Research Consortium for the Participating Institutions. The Participating Institutions are the American Museum of Natural History, Astrophysical Institute Potsdam, University of Basel, University of Cambridge, Case Western Reserve University, University of Chicago, Drexel University, Fermilab, the Institute for Advanced Study, the Japan Participation Group, Johns Hopkins University, the Joint Institute for Nuclear Astrophysics, the Kavli Institute for Particle Astrophysics and Cosmology, the Korean Scientist Group, the Chinese Academy of Sciences (LAMOST), Los Alamos National Laboratory, the Max Planck Institute for Astronomy (MPIA), the Max Planck Institute for Astrophysics (MPA), New Mexico State University, Ohio State University, University of Pittsburgh, University of Portsmouth, Princeton University, the U

  12. From ROOTS to GRAVI-1: Twenty Five Years for Understanding How Plants Sense Gravity

    Science.gov (United States)

    Perbal, Gerald

    2009-01-01

    In the 1970s, when I started to work on gravitropism at the University Pierre and Marie Curie, Paris), it was well known that statocytes contain voluminous amyloplasts (statoliths) that sediment under the influence of gravity. The role of these organelles in gravisensing was strongly disputed. In 1974, I attended a session of a meeting on gravitropism in Würzburg, where I presented results that supported the involvement of statoliths in the perception of gravity. This meeting had a strong impact on my research, since at that time the Council of Europe was looking for people interested in performing experiments in Space. Our first experiment (ROOTS) was carried out in the Biorack Facility (ESA) in the frame of the Spacelab D1 mission (1985). We had a very efficient help from CNES which developed a very fine hardware to grow lentil seedlings and to chemically fix them at the end of the experiment. The results obtained were surprising since we observed that in microgravity the statoliths were located at one pole of the statocyte and not distributed at random as it was expected. The goal of the following experiment (Spacelab IML-1 mission, 1992) was to determine the threshold stimulation time at 1 × g (created by centrifugation). It was estimated at 25 s. In the frame of the SMM/03 and SMM/06 missions (1996, 1997), we proved that the statoliths are attached to actin filaments by motor proteins (myosin) that make these organelles move in one preferential direction in microgravity. The analysis of gravisensitivity with clinostats incited us to compare gravisensitivity of lentil roots grown in microgravity or on a 1 × g centrifuge (SMM05 mission, 1997). It was found that the latter were less sensitive than the former. We showed that this was due to the fact that the statoliths are not distributed in the same way in both cases (microgravity or 1 × g centrifuge). All these studies led us to propose a mode of gravity sensing by plants in which elements of the

  13. Preparing Teacher-Students for Twenty-First-Century Learning Practices (PREP 21): A Framework for Enhancing Collaborative Problem-Solving and Strategic Learning Skills

    Science.gov (United States)

    Häkkinen, Päivi; Järvelä, Sanna; Mäkitalo-Siegl, Kati; Ahonen, Arto; Näykki, Piia; Valtonen, Teemu

    2017-01-01

    With regard to the growing interest in developing teacher education to match the twenty-first-century skills, while many assumptions have been made, there has been less theoretical elaboration and empirical research on this topic. The aim of this article is to present our pedagogical framework for the twenty-first-century learning practices in…

  14. Twenty-One Genome Sequences from Pseudomonas Species and 19 Genome Sequences from Diverse Bacteria Isolated from the Rhizosphere and Endosphere of Populus deltoides

    Energy Technology Data Exchange (ETDEWEB)

    Brown, Steven D [ORNL; Utturkar, Sagar M [ORNL; Klingeman, Dawn Marie [ORNL; Johnson, Courtney M [ORNL; Martin, Stanton [ORNL; Land, Miriam L [ORNL; Lu, Tse-Yuan [ORNL; Schadt, Christopher Warren [ORNL; Doktycz, Mitchel John [ORNL; Pelletier, Dale A [ORNL

    2012-01-01

    To aid in the investigation of the Populus deltoides microbiome we generated draft genome sequences for twenty one Pseudomonas and twenty one other diverse bacteria isolated from Populus deltoides roots. Genome sequences for isolates similar to Acidovorax, Bradyrhizobium, Brevibacillus, Burkholderia, Caulobacter, Chryseobacterium, Flavobacterium, Herbaspirillum, Novosphingobium, Pantoea, Phyllobacterium, Polaromonas, Rhizobium, Sphingobium and Variovorax were generated.

  15. Urban Middle School Students, Twenty-First Century Skills, and STEM-ICT Careers: Selected Findings from a Front-End Analysis

    Science.gov (United States)

    Cohen, Jonathan D.; Renken, Maggie; Calandra, Brendan

    2017-01-01

    As part of the design and development of an informal learning environment meant to increase urban middle school students' interest in technology-focused STEM careers, and to support their twenty-first century skill development, researchers developed and administered the ICT/Twenty-First Century Skills Questionnaire. Both STEM-ICT professionals and…

  16. Breast cancer epidemic in the early twenty-first century: evaluation of risk factors, cumulative questionnaires and recommendations for preventive measures.

    Science.gov (United States)

    Golubnitschaja, Olga; Debald, Manuel; Yeghiazaryan, Kristina; Kuhn, Walther; Pešta, Martin; Costigliola, Vincenzo; Grech, Godfrey

    2016-10-01

    Rapidly increasing incidence of breast cancer is a new social challenge resulting from a spectrum of internal and external risk factors which appear to be well accepted as an attribute of the early twenty-first century, being, however, new for female sub-populations compared to the past. These include altered socio-economical conditions such as occupational exposure, rotating shift work, specific environmental factors (increased pollution and environmental toxicity, altered dietary habits, quality and composition of meal) as well as consequently shifted and/or adapted physiologic factors such as lower age at menarche, late age of first full-term pregnancy, if any, shorter periods of breastfeeding and later menopause. Consolidated expert statements suggest that over 50 % of all breast cancer cases may be potentially prevented by risk reduction strategy such as regulation of modifiable risk factors. Currently available risk assessment models may estimate potential breast cancer predisposition, in general; however, they are not able to predict the disease manifestation individually. Further, current deficits in risk assessment and effective breast cancer prevention have been recently investigated and summarised as follows: gaps in risk estimation, preventive therapy, lifestyle prevention, understanding of the biology of breast cancer risk and implementation of known preventive measures. This paper overviews the most relevant risk factors, provides recommendations for improved risk assessment and proposes an extended questionnaire for effective preventive measures.

  17. Twenty-first century skills for students: hands-on learning after school builds school and life success.

    Science.gov (United States)

    Cabral, Leide

    2006-01-01

    At the core of the movement for twenty-first century skills are students. The growing efforts to increase programs leveraging out-of-school time are focused on giving American youth everything they need to compete in this increasingly complex world. The author is one of many students who have been well served by initiatives imparting twenty-first century skills during after-school hours. Now a senior at Boston Latin School, the author has been helped along the way by Citizen Schools, an after-school education program focused on hands-on learning apprenticeships and homework help. While enrolled in the program as a middle school student, the author took part in projects that exemplified hands-on, inquiry-based learning that helped her develop twenty-first century skills. For example, along with dozens of other students, she advanced her data analysis skills by analyzing statistics about Boston Public high schools, which also helped her select and enroll in one of the city's premier exam schools. Also, she and her peers worked with corporate attorneys who served as writing coaches and whose expertise the author drew from in producing a published essay and greatly improving her writing skills. The author now finds that the public speaking, leadership, organizational, social, and management abilities she built through her participation in Citizen Schools are a great asset to her in high school. The confidence with which she tackles her responsibilities can also be traced back to her experiences in the program. As she looks toward college, the author reflects and realizes that being actively involved in a quality after-school program put her on track for a successful future.

  18. What makes a bully a cyberbully? Unravelling the characteristics of cyberbullies across twenty-five European countries

    OpenAIRE

    Görzig, Anke; Ólafsson, Kjartan

    2013-01-01

    The characteristics of bullies who act face-to-face and those who do so in cyberspace were compared directly in one sample across twenty-five countries. The role of cross-country differences in technological infrastructure was also explored. Cyberbullies compared to face-to-face bullies were more likely to engage in risky online activities, spend more time online, and found it easier to be themselves online. Private access to the internet did not make a difference. Gender differences showed g...

  19. Algiers Point: Historical Ambience and Property Analysis of Squares Ten, Thirteen, and Twenty, with a View Toward Their Archaeological Potential,

    Science.gov (United States)

    1983-10-14

    to leave for a colder climate ." Admittance to the gathering place, the St. Charles Ballroom (in the IA) was on the basis of "Who were thought to be...cellar were 400 bottles of wine , twenty-two dozen bottles of beer, 400 empty bottles for filling, and barrels and demi-johns of syrup, salt, grease, tafia...plans for economic diversity in his suburb. The previous December he had begun a financial alliance with a family of Bordeaux shipbuilders, Pierre and

  20. Cumulative Index to Twenty Five Semiannual Reports of the Commission to the Congress. January 1947 - January 1959

    Energy Technology Data Exchange (ETDEWEB)

    McCone, John A.

    1960-01-31

    The first twenty five semiannual reports of the United States Atomic Energy Commission to Congress cover the major unclassified activities of the Commission from January 1947 through January 1959. In addition to the semiannual summaries, a series of special reports on important atomic energy programs were included in many of the semiannual reports. This cumulative name and subject index provides a guide to the information published in these reports. Beginning in 1960, the Commission will be issuing annual reports, each separately indexed, ceasing the semiannual reporting.

  1. Twenty months of evolution following sympathectomy on patients with palmar hyperhidrosis: sympathectomy at the T3 level is better than at the T2 level

    Directory of Open Access Journals (Sweden)

    Guilherme Yazbek

    2009-01-01

    Full Text Available OBJECTIVE: To compare two surgical techniques (denervation levels for sympathectomy using video-assisted thoracoscopy to treat palmar hyperhidrosis in the long-term. METHODS: From May 2003 to June 2006, 60 patients with palmar hyperhidrosis were prospectively randomized for video-assisted thoracoscopic sympathectomy at the T2 or T3 ganglion level. They were followed for a mean of 20 months and were evaluated regarding their degree of improvement of palmar hyperhidrosis, incidence and severity of compensatory hyperhidrosis and its evolution over time, and quality of life. RESULTS: Fifty-nine cases presented resolution of the palmar hyperhidrosis. One case of therapeutic failure occurred in the T3 group. Most of the patients presented an improvement in palmar hyperhidrosis, without any difference between the groups. Twenty months later, all patients in both groups presented some degree of compensatory hyperhidrosis but with less severity in the T3 group (p = 0.007. Compensatory hyperhidrosis developed in most patients during the first month after the operation, with incidence and severity that remained stable over time. An improvement in quality of life was seen starting from the first postoperative evaluation but without any difference between the groups. This improvement was maintained until the end of the follow-up. CONCLUSION: Both techniques were effective for treating palmar hyperhidrosis. The most frequent complication was compensatory hyperhidrosis, which presented stable incidence and severity over the study period. Sympathectomy at the T3 level presented compensatory hyperhidrosis with less severity. Nevertheless, the improvement in quality of life was similar between the groups.

  2. Stapedotomy in osteogenesis imperfecta : a prospective study of 32 consecutive cases

    NARCIS (Netherlands)

    Vincent, Robert; Wegner, Inge; Stegeman, Inge; Grolman, Wilko

    2014-01-01

    OBJECTIVE: To prospectively evaluate hearing outcomes in patients with osteogenesis imperfecta undergoing primary stapes surgery and to isolate prognostic factors for success. STUDY DESIGN: A nonrandomized, open, prospective case series. SETTING: A tertiary referral center. PATIENTS: Twenty-five

  3. Public Heath in Colonial and Post-Colonial Ghana: Lesson-Drawing for The Twenty-First Century

    Directory of Open Access Journals (Sweden)

    Adu-Gyamfi, Samuel

    2017-06-01

    Full Text Available Public health in twenty-first century Ghana is mired with several issues ranging from the inadequacy of public health facilities, improper settlement planning, insanitary conditions, and the inadequacy of laws and their implementation. This situation compared to the colonial era is a direct contradiction. Development in the pre-colonial era to the colonial era sought to make the prevention of diseases a priority in the colonial administration. This was begun with the establishment of the health branch in 1909 as a response to the bubonic plague that was fast spreading in the colony. From here public health policies and strategies were enacted to help the diseases prevention cause. Various public health boards, the medical research institute or the laboratory branch, the waste management department, the use of preventive medicine and maintenance of good settlement planning and sanitation were public health measures in the colonial era. This research seeks to analyse the public health system in the colonial era so as to draw basic lessons for twenty-first century Ghana. Archival data and other secondary sources are reviewed and analysed to help draw these lessons. Richard Rose’s lesson-drawing approach was used to draw the lessons.

  4. Serum concentrations and profiles of polychlorinated biphenyls in Taiwan Yu-cheng victims twenty years after the incident

    Energy Technology Data Exchange (ETDEWEB)

    Lung, S.-C. Candice [Research Center for Environmental Changes, Academia Sinica, Nankang, Taipei, Taiwan 115 (China); Guo, Y.-L.L. [Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, 138 Sheng-Li Rd., Tainan, Taiwan 70428 (China); Chang, H.-Y.[Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, 138 Sheng-Li Rd., Tainan, Taiwan 70428 (China)]. E-mail: h7154@mail.ncku.edu.tw

    2005-07-15

    In 1979, about 2000 people in central Taiwan were intoxicated via rice oil consumption that was contaminated with polychlorinated biphenyls (PCBs). This 'Yu-cheng' incident was one of the two known major human PCB intoxication episodes. Twenty years after the intoxication, serum samples of 435 Yu-cheng victims, 414 adults and 21 children, were collected. Sixteen PCB congeners were analyzed with a gas chromatograph-electron capture detector. We found the median concentration of total PCBs in the adult serum was 1500 ng/g lipid, still substantially higher than that of the general population in Taiwan (3.7-fold) and most seafood consumers in the world. Most of analyzed PCB congeners in children were below or around the detection limits. Congener no. 138, however, had the highest concentrations, approximately accounting for 55% and 29% in the child and adult groups, respectively. Given that PCBs are persistent organic pollutants and endocrine disruptors, the concentrations and congener-specific profiles regarding the Yu-cheng victims provide valuable information for the investigation of such chemicals in humans. - Total serum PCBs in the Yu-cheng adult victims twenty years after the incident were still higher than that of the general population in Taiwan.

  5. Case Report Case Report

    African Journals Online (AJOL)

    User

    2013-03-26

    Mar 26, 2013 ... was found that though there was no significant change no evidence of ascites or lymphadenopathy. Liver, ga kidneys and adrenal appeared normal. ... inoperable cancer. CASE REPORT. A 61 years old male, chronic alcoholic chronic smoker presented with 2 years histo abdominal fullness and dyspeptic ...

  6. Chapter Twenty Six

    African Journals Online (AJOL)

    User

    poetical element than is often realized. The five canticles of Luke's nativity narrative are well known, but the prologue of John is probably based on Christian hymn (Guthrie, and Motyer,. 1980). Hebrew poetry, as that of other literatures of the ancient Near East, is characterized by parallelism or rhythmic balance of thought.

  7. Chapter Twenty Six

    African Journals Online (AJOL)

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    in the Jewish Canon, and were only adopted formally as authoritative Scripture after the life .... And they (the dogs) turn to attack you. ..... characteristic life. There is the theme of death, which carries no great charge of emotion save the simplicity of loss, for the thought of eternity does not often come in the Old Testament to ...

  8. Twenty years publishing science

    Directory of Open Access Journals (Sweden)

    Marco González T.

    2014-03-01

    Full Text Available The Journal MVZ Córdoba is a scientific publication of the Faculty of Veterinary Medicine and Zootechny of the University of Córdoba in Montería, Colombia. Its mission is to publish scientific and technological knowledge of agricultural sciences and its vision is to become a national and international consulting reference in the field of agricultural sciences and to promote ethic values that contribute to the development of scientific and technological investigation.

  9. Chapter Twenty Three

    African Journals Online (AJOL)

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    Freud's recognition of the “super-ego” and the attachment of the “psychological group” to the concept of an immanent being and other phenomenological beings explain this ritual liturgy. Freud's association of cultural, artistic and social creations with the influence of 'sexual impulses' conditions festivals to be a form of social ...

  10. Twenty Years of AIRE

    Directory of Open Access Journals (Sweden)

    Roberto Perniola

    2018-02-01

    Full Text Available About two decades ago, cloning of the autoimmune regulator (AIRE gene materialized one of the most important actors on the scene of self-tolerance. Thymic transcription of genes encoding tissue-specific antigens (ts-ags is activated by AIRE protein and embodies the essence of thymic self-representation. Pathogenic AIRE variants cause the autoimmune polyglandular syndrome type 1, which is a rare and complex disease that is gaining attention in research on autoimmunity. The animal models of disease, although not identically reproducing the human picture, supply fundamental information on mechanisms and extent of AIRE action: thanks to its multidomain structure, AIRE localizes to chromatin enclosing the target genes, binds to histones, and offers an anchorage to multimolecular complexes involved in initiation and post-initiation events of gene transcription. In addition, AIRE enhances mRNA diversity by favoring alternative mRNA splicing. Once synthesized, ts-ags are presented to, and cause deletion of the self-reactive thymocyte clones. However, AIRE function is not restricted to the activation of gene transcription. AIRE would control presentation and transfer of self-antigens for thymic cellular interplay: such mechanism is aimed at increasing the likelihood of engagement of the thymocytes that carry the corresponding T-cell receptors. Another fundamental role of AIRE in promoting self-tolerance is related to the development of thymocyte anergy, as thymic self-representation shapes at the same time the repertoire of regulatory T cells. Finally, AIRE seems to replicate its action in the secondary lymphoid organs, albeit the cell lineage detaining such property has not been fully characterized. Delineation of AIRE functions adds interesting data to the knowledge of the mechanisms of self-tolerance and introduces exciting perspectives of therapeutic interventions against the related diseases.

  11. Chapter Twenty Nine

    African Journals Online (AJOL)

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    goodness sake, call it off. (Marry Umeh, in Modupe Kolawole, 1997). This suggests a middle of the road approach to feminist ideals which has attracted much criticism from hard-line feminist scholars who see this detachment from mainstream feminism as defeatist. Omolara Ogundipe – Leslie strongly frowns at these denials ...

  12. Chapter Twenty Seven

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    created in postcolonial African literature is a modification of Jagua Nana, or a fictional representation of some attribute of Jagua Nana as a character. As a literary archetype, the image of the prostitute adopted by Ekwensi goes far back into history. Prostitution is acknowledged to be one of the oldest professions the human ...

  13. Chapter Twenty Two

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    African literature has been at the forefront of this engagement and intervention. Today, there ..... (TFA 123). The church as represented by Mr. Brown grows from strength to strength as it sustains its links with the new .... manly dispositions, he refuses to accept financial help from Clara, a girl who he claims he wants to marry.

  14. Chapter Twenty Seven

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    Victorian England and some contemporary societies, the paper x –rays the African novelist's diagnosis of the ... One of the fictional stereotypes that have developed in western ..... on gender relations in a patriarchal society. The prostitute ...

  15. Chapter Twenty Nine

    African Journals Online (AJOL)

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    divergence of views in its discourse. From the liberal to the radical feminist, arguments abound as to which gender theory best would suit the African environment without it serving as “a red rag to the bull of the African male”. Of the Afro- feminists worthy of mention, Buchi Emecheta occupies the front row. She claims not to ...

  16. JFK: Twenty Years Later.

    Science.gov (United States)

    Parmet, Herbert

    1984-01-01

    The presidency of John F. Kennedy is assessed. Considered are J.F.K's positions on, and national and world leaders' reactions to, such issues as oil depletion allowances, the Civil Rights Bill, the Vietnam situation, and the Cold War missile gap. (RM)

  17. Chapter Twenty One

    African Journals Online (AJOL)

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    Abstract. In this paper I approach art through some literary expositions of Uche Okeke. These expositions, I argue, are a direct influence of Chinua Achebe's Things Fall Apart which Okeke illustrated in 1958. The paper postulates that Uli could present as a dominant ideology in the artistic genre if one juxtaposes it with the ...

  18. case series

    African Journals Online (AJOL)

    Administrator

    Conclusions: The concept of “case series” is not well defined in the literature and does not reflect a specific research design. We suggest that a case series should have more than four patients while four paitents or less should be reported individually as case reports. Key words: Case report, case series, concept analysis, ...

  19. Twenty-First Century Instructional Classroom Practices and Reading Motivation: Probing the Effectiveness of Interventional Reading Programs

    Directory of Open Access Journals (Sweden)

    Taoufik Boulhrir

    2017-07-01

    Full Text Available Twenty-first century education has undoubtedly witnessed changes of the definition of literacy to cope with the economic, social, and intellectual trends. Technological advances, which include skills of communication, creativity, critical thinking, and collaboration have become key in education, especially when dealing with literacy and reading motivation. As motivation hinges around two major theoretical approaches, intrinsic and extrinsic, numerous studies argue for the first to be more sustainable in enhancing reading motivation. Accordingly, many research-based interventional programs have emerged since the late nineties with increasing popularity to offer answers to the dwindling rates in reading among youth. This article discusses traits of 21st century education in light of trends and challenges as it probes the effectiveness of some interventional programs that are meant, and argued for, to enhance literacy skills and reading motivation.

  20. The horror of stigma: psychosis and mental health care environments in twenty-first-century horror film (part II).

    Science.gov (United States)

    Goodwin, John

    2014-10-01

    This paper highlights the specific manner in which twenty-first-century horror films stigmatize psychosis and mental health care environments (MHCEs) A search on various film forums using the terms "mental/psychiatric patient," "psychosis/psychoses," and "mental/psychiatric hospital" (limited from 2000 to 2012) revealed 55 films. A literature review revealed criteria for a checklist. Subsequent to viewings, salient recurring criteria were added to the checklist. Films were systematically analyzed under these criteria. Homicidal maniacs are the most common stereotypes. Misinformation is often communicated. Familiar horror tropes are used to stigmatize MHCEs. Practitioners should be aware of the specific manner in which clients are being stigmatized by the media. This paper highlights specific ways in which psychosis and MHCEs are stigmatized, and encourages practitioners to challenge these depictions. © 2013 Wiley Periodicals, Inc.

  1. The Renaissance of Word-of-Mouth Marketing: A ‘New’ Standard in Twenty-First Century Marketing Management?!

    Directory of Open Access Journals (Sweden)

    Norbert H. Meiners

    2010-12-01

    Full Text Available In this paper the importance of word of mouth for marketing management in the twenty-first century will be discussed. After a short introduction, there will be a focus on the demarcations and problems of traditional marketing. Then, in the third section, word ofmouth (WOM and word-of-mouth marketing (WOMM as a ‘new’ standard in modern marketing are described. The fourth section broaches the importance of word of mouth and word-of-mouth marketing from the point of view of business and consumers, and then in the fifth section their importance for the Internet is considered. Finally, in section six evangelism marketing is discussed as the most effective form of word-of-mouth marketing. Section seven concludes the paper with a short summary. The paper focuses on scholarly articles andcurrent research so as to keep theory as close as possible to reality.

  2. Visit ALEPH experiment on the LEP collider by twenty-eight young scientists chosen to represent their respective countries

    CERN Multimedia

    Laurent Guiraud

    1998-01-01

    Following an international meeting of secondary school pupils on the theme of "Future Scientists: Women and Men" in Paris on 23 and 24 April. The aim of this meeting, which was organised by UNESCO, was to encourage young people, and girls in particular, to choose scientific studies and careers. Twenty-eight young scientists chosen to represent their respective countries visited the CERN site this week following an international meeting of secondary school pupils on the theme of "Future Scientists: Women and Men" in Paris on 23 and 24 April. The aim of this meeting, which was organised by UNESCO, was to encourage young people, and girls in particular, to choose scientific studies and careers.

  3. Us, them, and others: reflections on Canadian multiculturalism and national identity at the turn of the twenty-first century.

    Science.gov (United States)

    Winter, Elke

    2014-05-01

    The John Porter Lecture at the annual meeting of the Canadian Sociological Association in Victoria 2013 draws upon my book Us, Them, and Others: Pluralism and National Identity in Diverse Societies. Incorporating the findings from an analysis of Canadian English-language newspaper discourses during the 1990s into a theoretical framework inspired by Weberian sociology, the book argues that pluralism is best understood as a dynamic set of triangular relations where the compromise between unequal groups--"us" and "others"--is rendered meaningful through the confrontation with real or imagined outsiders ("them"). The lecture summarizes the theoretical contribution and explains how multiculturalism became consolidated in dominant Canadian discourses in the late 1990s. The lecture then discusses changes to Canadian multicultural identity at the beginning of the twenty-first century.

  4. Mechanical design of multiple zone plates precision alignment apparatus for hard X-ray focusing in twenty-nanometer scale

    Science.gov (United States)

    Shu, Deming; Liu, Jie; Gleber, Sophie C.; Vila-Comamala, Joan; Lai, Barry; Maser, Jorg M.; Roehrig, Christian; Wojcik, Michael J.; Vogt, Franz Stefan

    2017-04-04

    An enhanced mechanical design of multiple zone plates precision alignment apparatus for hard x-ray focusing in a twenty-nanometer scale is provided. The precision alignment apparatus includes a zone plate alignment base frame; a plurality of zone plates; and a plurality of zone plate holders, each said zone plate holder for mounting and aligning a respective zone plate for hard x-ray focusing. At least one respective positioning stage drives and positions each respective zone plate holder. Each respective positioning stage is mounted on the zone plate alignment base frame. A respective linkage component connects each respective positioning stage and the respective zone plate holder. The zone plate alignment base frame, each zone plate holder and each linkage component is formed of a selected material for providing thermal expansion stability and positioning stability for the precision alignment apparatus.

  5. On ‘a Continuum with Expansion’? Intelligence Cooperation in Europe in the Early Twenty-first Century

    Directory of Open Access Journals (Sweden)

    Adam D.M. Svendsen

    2011-12-01

    Full Text Available This article argues that during the early twenty-first century, generally we have witnessed greater intelligence co-operation in Europe. Indeed, we can even appropriately discuss the increased 'regionalisation of intelligence'. Effectively reflecting 'uneven and combined development', persistently these co-operative intelligence trends appear to be occurring haphazardly, non-uniformly and at several different rates at the different levels of relations in the various 'pockets' of European intelligence co-operation. This article concludes by arguing that overall there is the development of an ever-more complex web consisting of a plethora of various overlapping international intelligence liaison arrangements that collectively provide a form of regional intelligence coverage in Europe. How they overlap is important, accounting for the connections, and notably the 'disconnects', that publicly come to our attention.

  6. Historical Approach to the Role of Women in the Legislation of Iran: A Case Study on the Twenty-First Parliament

    OpenAIRE

    Sarah Sheibani; Shiva Jalalpour

    2017-01-01

    One hundred and ten years ago, men and women took constitutionalism to achieve justice in Iran. National Council was the result of the Iranian people's struggle for justice, both women and men. Men policies from the beginning of legislation put women as minors and lunatics and bankrupted and banned them from vote. However, the Constitutional Revolution as a turning point and a national revolution played a key role in changing attitudes to women and structural context of their participation pr...

  7. Townes-Brocks syndrome: twenty novel SALL1 mutations in sporadic and familial cases and refinement of the SALL1 hot spot region.

    Science.gov (United States)

    Botzenhart, Elke M; Bartalini, Gabriella; Blair, Edward; Brady, Angela F; Elmslie, Frances; Chong, Karen L; Christy, Katie; Torres-Martinez, Wilfredo; Danesino, Cesare; Deardorff, Matthew A; Fryns, Jean-Pierre; Marlin, Sandrine; Garcia-Minaur, Sixto; Hellenbroich, Yorck; Hay, Beverly N; Penttinen, Maila; Shashi, Vandana; Terhal, Paulien; Van Maldergem, Lionel; Whiteford, Margo L; Zackai, Elaine; Kohlhase, Jürgen

    2007-02-01

    Townes-Brocks syndrome (TBS) is an autosomal dominant malformation syndrome characterized by renal, anal, ear, and thumb anomalies caused by SALL1 mutations. To date, 36 SALL1 mutations have been described in TBS patients. All but three of those, namely p.R276X, p.S372X, and c.1404dupG, have been found only in single families thereby preventing phenotype-genotype correlations. Here we present 20 novel mutations (12 short deletions, five short duplications, three nonsense mutations) in 20 unrelated families. We delineate the phenotypes and report previously unknown ocular manifestations, i.e. congenital cataracts with unilateral microphthalmia. We show that 46 out of the now 56 SALL1 mutations are located between the coding regions for the glutamine-rich domain mediating SALL protein interactions and 65 bp 3' of the coding region for the first double zinc finger domain, narrowing the SALL1 mutational hotspot region to a stretch of 802 bp within exon 2. Of note, only two SALL1 mutations would result in truncated proteins without the glutamine-rich domain, one of which is reported here. The latter is associated with anal, ear, hand, and renal manifestations, indicating that the glutamine-rich domain is not required for typical TBS. (c) 2006 Wiley-Liss, Inc.

  8. Diaphragmatic herniorrhaphy in dogs and cats. Report of twenty-two cases and proposition of technique for correction of phrenocostal tears

    Directory of Open Access Journals (Sweden)

    Alceu Gaspar Raiser

    1994-12-01

    Full Text Available No período de janeiro de 1984 a dezembro de 1992 foram reduzidas pelo autor 22 hérnias diafragmáticas, em cães e gatos, através de abordagem intercostal. Os animais fizeram parte da casuística do Hospital de Clínicas Veterinárias da Universidade Federal de Santa Maria. Em todos os casos a hérnia foi adquirida, de origem traumática. Os órgãos comumente herniados foram o fígado, estômago, alça intestinal, baço e epíploo. As complicações foram efusão pleural por compressão hepática e timpanização gástrica. Um gato e dois cães morreram durante as tomadas radiográficas, uma cadela durante indução anestésica, outra 4 horas após a cirurgia. Os demais apresentaram excelente índice de recuperação. Em 9 animais com ruptura freno-costal a redução foi feita por deslocamento cranial do hemidiafragma até o oitavo espaço intercostal com bom resultado.

  9. Relative Citation Ratio of Top Twenty Macedonian Biomedical Scientists in PubMed: A New Metric that Uses Citation Rates to Measure Influence at the Article Level

    Directory of Open Access Journals (Sweden)

    Mirko Spiroski

    2016-06-01

    Conclusion: It is necessary to accept top twenty Macedonian biomedical scientists as an example of new metric that uses citation rates to measure influence at the article level, rather than qualification of the best Macedonian biomedical scientists.

  10. Estimates of herbicide use for the twenty-first through the fortieth most-used herbicides in the conterminous United States

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This coverage contains estimates of herbicide use for the twenty-first through the fortieth most-used herbicides in the conterminous United States as reported in...

  11. Cutaneous signs of systemic toxicity due to dioxins and related chemicals

    Energy Technology Data Exchange (ETDEWEB)

    Dunagin, W.G.

    1984-04-01

    The controversy about dioxin effects on human health received a great deal of attention recently when the State of Missouri was declared to have a dioxin crisis. However, dioxin and several related chemicals are widespread throughout the world. Cutaneous signs play an important part in evaluating toxicity of dioxin and similar chemicals. Chloracne is the most sensitive indicator of significant dioxin exposure. Porphyria cutanea tarda and hyperpigmentation are other known cutaneous effects, and malignant fibrous histiocytomas of the skin may possibly be associated, although data are inconclusive on this point. The AMC Council on Scientific Affairs recommended that all physicians become familiar with chloracne and other toxic effects of dioxin. Dermatologists, especially, should be aware of the problem and may discover early cases of previously unsuspected exposure to this group of chemicals.

  12. Case study research in information systems engineering: how to generalize, how not to generalize, and how not to generalize too much

    NARCIS (Netherlands)

    Wieringa, Roelf J.

    Case studies are detailed studies of a small number of real-world cases in order to understand the mechanisms that play a role in creating phenomena in the case. Case studies have been performed in the information systems discipline for at least twenty years. In this talk I will show what role case

  13. The Significance, for Readers in the Twenty-first Century, of the Character of Safie in Mary Shelley's Frankestein

    Directory of Open Access Journals (Sweden)

    Esther Katheu Mbithi

    2017-02-01

    Full Text Available The Significance, for Readers in the Twenty-first century, of the Character of Safie in Mary Shelley's Frankenstein. Abstract: This paper presents a critical look at one of the characters in Mary Shelley’s Frankenstein, Safie, through the lenses of a female African scholar in the twenty-first century. A close look at the narrative structure leads to the gradual peeling off of the first two layers, to the core of the narration. The paper looks keenly at a minor character in this core, in the light of feminist literary criticism and against the concept of globalisation. The analysis of the character of Safie, carried out in full consciousness of the fact that Frankenstein was written two hundred years ago, involves a look at the words used to describe her; comparison between her and other characters, particularly other female characters; as well as a general overview of her circumstances and how she reacts in response to them. Keywords: literature, English, Gothic, Romanticism, feminism, Frankestein. // El significado del personaje de Safie en Frankestein, de Mary Shelley, para los lectores del siglo XXI. Resumen: Este artículo estudia críticamente a Safie, uno de los personajes de Frankestein de Mary Shelley, desde la perspectiva de una investigadora africana. Un examen atento de la estructura narrativa de la novela permite despojarla de sus dos capas exteriores, para alcanzar el núcleo de la narración. Este trabajo examina un personaje secundario de este núcleo a la luz de la crítica literaria feminista y en contra del concepto de globalización. El análisis del personaje de Safie, realizado con plena conciencia del hecho de que Frankestein fue escrito hace doscientos años, exige el examen de los términos usados para describirla; la comparación entre ella y otros personajes, especialmente otros personajes femeninos; así como una contextualización de sus circunstancias y de cómo Safie reacciona ante ellas. Palabras clave

  14. The Youngest Korean Case of Urachal Carcinoma

    OpenAIRE

    Seung Ryeol Lee; Haeyoun Kang; Moon Hyung Kang; Young Dong Yu; Chang Il Choi; Kyung Hwa Choi; Dong Soo Park; Young Kwon Hong

    2015-01-01

    Urachal anomalies are relatively uncommon and result from incomplete obliteration of the urachus perinatally. In children, most urachal diseases including urachal cysts and sinuses are benign, and these can sometimes become secondarily infected. Malignant involvement of the urachus is rarely reported, one in 5 million people, accounting for 0.35% to 0.7% of all bladder cancers. There are only five cases of urachal cancer diagnosed at the age of twenties in English written literature. Age at t...

  15. Visual impairment from uveitis in a reference hospital of Southeast Brazil: a retrospective review over a twenty years period.

    Science.gov (United States)

    Silva, Luci Meire Pereira da; Muccioli, Cristina; Oliveira, Filipe de; Arantes, Tiago Eugênio; Gonzaga, Lucas Renó; Nakanami, Célia Regina

    2013-01-01

    To identify the frequency and causes of uveitis leading to visual impairment in patients referred to the Low Vision Service - Department of Ophthalmology - UNIFESP, over a twenty years period. In a retrospective study, medical records of 5,461 patients were reviewed. Data from the first clinical evaluation at the Low Vision Service were collected, patient's age, gender and cause of visual impairment were analyzed. Patients with uveitis had their chart reviewed for anatomical classification and clinical diagnosis. The mean age of the patients referred to the Low Vision Service was 42.86 years and the mean age of patients with uveitis diagnosis was 25.51 years. Retinal disorders were the most common cause of visual impairment (N=2,835 patients; 51.9%) followed by uveitis (862 patients, 15.7%). Uveitis was posterior in 792 patients (91.9% of uveitis) and toxoplasmosis was the most common diagnosis (765 patients, 88.7%). In our study, uveitis represents the second cause of visual impairment in patients referred for visual rehabilitation and toxoplasmic retinochoroiditis was the most common clinical diagnosis. It affects a young working age population with a relevant social and economic impact, but the early diagnosis and treatment can improve the quality of life of these patients.

  16. Visual impairment from uveitis in a reference hospital of Southeast Brazil: a retrospective review over a twenty years period

    Directory of Open Access Journals (Sweden)

    Luci Meire Pereira da Silva

    2013-12-01

    Full Text Available PURPOSE: To identify the frequency and causes of uveitis leading to visual impairment in patients referred to the Low Vision Service - Department of Ophthalmology - UNIFESP, over a twenty years period. METHODS: In a retrospective study, medical records of 5,461 patients were reviewed. Data from the first clinical evaluation at the Low Vision Service were collected, patient's age, gender and cause of visual impairment were analyzed. Patients with uveitis had their chart reviewed for anatomical classification and clinical diagnosis. RESULTS: The mean age of the patients referred to the Low Vision Service was 42.86 years and the mean age of patients with uveitis diagnosis was 25.51 years. Retinal disorders were the most common cause of visual impairment (N=2,835 patients; 51.9% followed by uveitis (862 patients, 15.7%. Uveitis was posterior in 792 patients (91.9% of uveitis and toxoplasmosis was the most common diagnosis (765 patients, 88.7%. CONCLUSIONS: In our study, uveitis represents the second cause of visual impairment in patients referred for visual rehabilitation and toxoplasmic retinochoroiditis was the most common clinical diagnosis. It affects a young working age population with a relevant social and economic impact, but the early diagnosis and treatment can improve the quality of life of these patients.

  17. Twenty-one-month follow-up study of school-age children exposed to Hurricane Andrew.

    Science.gov (United States)

    Shaw, J A; Applegate, B; Schorr, C

    1996-03-01

    To explore the 21-month course of posttraumatic stress symptomatology (PTSS) and psychological morbidity in 30 school-age children (7 to 13 years) after exposure to Hurricane Andrew. Pynoos' Posttraumatic Stress Disorder Reaction Index and Achenbach's Teacher's Report Form were administered at 8 and 21 months after Hurricane Andrew. At 21 months 70% of the children endorsed moderate-severe PTSS. The reduction in PTSS was greater for boys than girls. Psychopathology as measured by the Teacher's Report Form increased over the 19-month period. Boys demonstrated significant increases in internalizing symptoms and in Withdrawn, Anxious/Depressed, Social Problems, and Attention Problems scales, and girls showed a significant increase in the Anxious/Depressed scale. Twenty-one months after exposure to Hurricane Andrew, there were continuing high levels of PTSS and evidence of increasing emotional and behavioral problems. While girls sustained higher levels of PTSS, boys demonstrated higher indices of other psychopathology. The enduring effects of disaster associated with secondary stressors and "traumatic reminders" continue to be etiologically important for continuing psychological morbidity.

  18. The Association of Academic Health Sciences Libraries Annual Statistics: an exploratory twenty-five-year trend analysis.

    Science.gov (United States)

    Byrd, Gary D; Shedlock, James

    2003-04-01

    This paper presents an exploratory trend analysis of the statistics published over the past twenty-four editions of the Annual Statistics of Medical School Libraries in the United States and Canada. The analysis focuses on the small subset of nineteen consistently collected data variables (out of 656 variables collected during the history of the survey) to provide a general picture of the growth and changing dimensions of services and resources provided by academic health sciences libraries over those two and one-half decades. The paper also analyzes survey response patterns for U.S. and Canadian medical school libraries, as well as osteopathic medical school libraries surveyed since 1987. The trends show steady, but not dramatic, increases in annual means for total volumes collected, expenditures for staff, collections and other operating costs, personnel numbers and salaries, interlibrary lending and borrowing, reference questions, and service hours. However, when controlled for inflation, most categories of expenditure have just managed to stay level. The exceptions have been expenditures for staff development and travel and for collections, which have both outpaced inflation. The fill rate for interlibrary lending requests has remained steady at about 75%, but the mean ratio of items lent to items borrowed has decreased by nearly 50%.

  19. Twenty-first century projected summer mean climate in the Mediterranean interpreted through the monsoon-desert mechanism

    Science.gov (United States)

    Cherchi, Annalisa; Annamalai, H.; Masina, Simona; Navarra, Antonio; Alessandri, Andrea

    2016-10-01

    The term "monsoon-desert mechanism" indicates the relationship between the diabatic heating associated with the South Asian summer monsoon rainfall and the remote response in the western sub-tropics where long Rossby waves anchor strong descent with high subsidence. In CMIP5 twenty-first century climate scenarios, the precipitation over South Asia is projected to increase. This study investigates how this change could affect the summer climate projections in the Mediterranean region. In a linear framework the monsoon-desert mechanism in the context of climate change would imply that the change in subsidence over the Mediterranean should be strongly linked with the changes in South Asian monsoon precipitation. The steady-state solution from a linear model forced with CMIP5 model projected precipitation change over South Asia shows a broad region of descent in the Mediterranean, while the results from CMIP5 projections differ having increased descent mostly in the western sector but also decreased descent in parts of the eastern sector. Local changes in circulation, particularly the meridional wind, promote cold air advection that anchors the descent but the barotropic Rossby wave nature of the wind anomalies consisting of alternating northerlies/southerlies favors alternating descent/ascent locations. In fact, the local mid-tropospheric meridional wind changes have the strongest correlation with the regions where the difference in subsidence is largest. There decreased rainfall is mostly balanced by changes in moisture, omega and in the horizontal advection of moisture.

  20. B. F. Skinner’s legacy twenty years after (1990-2010: Behavior analysis in Ibero-America

    Directory of Open Access Journals (Sweden)

    Wilson M. López López

    2010-01-01

    Full Text Available Twenty years after his death (August 18th 1990,B. F. Skinner leaves five major living legacies: 1radical behaviorism; 2 the experimental analysis ofbehavior; 3 applied behavior analysis; 4 the Skinnerbox; 5 the Horcones community (Mexico.Behavior analysis is recognized for its internationalactive presence. Its growth provides a set of opportunitiesfor knowledge and technology transferenceand reminds us the importance of working for thedevelopment of educational and research programsand the arrangement of contingencies which enableits advance. In Ibero-America, behavior analysis, asa Skinnerian legacy, has been an important traditionwithin psychology. In this article we will presenta current synthesis of the central Ibero-Americancontributions to Behavior analysis. The panoramaof Behavior analysis in Ibero-America will beanalyzed according to the following dimensions:1 the most relevant figures; 2 the academic communityrelated to the Behavior Analytic tradition;and 3 the most important research lines. Finally,some of the most general characteristics of Ibero-American Behavior analysis are included.

  1. Building Interdisciplinary Leadership Skills among Health Practitioners in the Twenty-First Century: An Innovative Training Model.

    Science.gov (United States)

    Negandhi, Preeti; Negandhi, Himanshu; Tiwari, Ritika; Sharma, Kavya; Zodpey, Sanjay P; Quazi, Zahiruddin; Gaidhane, Abhay; Jayalakshmi N; Gijare, Meenakshi; Yeravdekar, Rajiv

    2015-01-01

    Transformational learning is the focus of twenty-first century global educational reforms. In India, there is a need to amalgamate the skills and knowledge of medical, nursing, and public health practitioners and to develop robust leadership competencies among them. This initiative proposed to identify interdisciplinary leadership competencies among Indian health practitioners and to develop a training program for interdisciplinary leadership skills through an Innovation Collaborative. Medical, nursing, and public health institutions partnered in this endeavor. An exhaustive literature search was undertaken to identify leadership competencies in these three professions. Published evidence was utilized in searching for the need for interdisciplinary training of health practitioners, including current scenarios in interprofessional health education and the key competencies required. The interdisciplinary leadership competencies identified were self-awareness, vision, self-regulation, motivation, decisiveness, integrity, interpersonal communication skills, strategic planning, team building, innovation, and being an effective change agent. Subsequently, a training program was developed, and three training sessions were piloted with 66 participants. Each cohort comprised a mix of participants from different disciplines. The pilot training guided the development of a training model for building interdisciplinary leadership skills and organizing interdisciplinary leadership workshops. The need for interdisciplinary leadership competencies is recognized. The long-term objective of the training model is integration into the regular medical, nursing, and public health curricula, with the aim of developing interdisciplinary leadership skills among them. Although challenging, formal incorporation of leadership skills into health professional education is possible within the interdisciplinary classroom setting using principles of transformative learning.

  2. Building Interdisciplinary Leadership Skills among Health Practitioners in the Twenty-First Century: An Innovative Training Model

    Science.gov (United States)

    Negandhi, Preeti; Negandhi, Himanshu; Tiwari, Ritika; Sharma, Kavya; Zodpey, Sanjay P.; Quazi, Zahiruddin; Gaidhane, Abhay; Jayalakshmi N.; Gijare, Meenakshi; Yeravdekar, Rajiv

    2015-01-01

    Transformational learning is the focus of twenty-first century global educational reforms. In India, there is a need to amalgamate the skills and knowledge of medical, nursing, and public health practitioners and to develop robust leadership competencies among them. This initiative proposed to identify interdisciplinary leadership competencies among Indian health practitioners and to develop a training program for interdisciplinary leadership skills through an Innovation Collaborative. Medical, nursing, and public health institutions partnered in this endeavor. An exhaustive literature search was undertaken to identify leadership competencies in these three professions. Published evidence was utilized in searching for the need for interdisciplinary training of health practitioners, including current scenarios in interprofessional health education and the key competencies required. The interdisciplinary leadership competencies identified were self-awareness, vision, self-regulation, motivation, decisiveness, integrity, interpersonal communication skills, strategic planning, team building, innovation, and being an effective change agent. Subsequently, a training program was developed, and three training sessions were piloted with 66 participants. Each cohort comprised a mix of participants from different disciplines. The pilot training guided the development of a training model for building interdisciplinary leadership skills and organizing interdisciplinary leadership workshops. The need for interdisciplinary leadership competencies is recognized. The long-term objective of the training model is integration into the regular medical, nursing, and public health curricula, with the aim of developing interdisciplinary leadership skills among them. Although challenging, formal incorporation of leadership skills into health professional education is possible within the interdisciplinary classroom setting using principles of transformative learning. PMID:26501046

  3. Energy and environmental policy in a period of transition. Proceedings of the twenty-third annual Illinois energy conference

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-31

    The Twenty-Third Annual Illinois Energy Conference entitled, ``Energy and Environmental Policy in a Period of Transition`` was held in Chicago, Illinois on November 20--21, 1995. The conference program explored how federal policy in energy and environment is changing and how these shifts will impact the economy of the Midwest. The conference was divided in four plenary sessions. Session 1 focused on the national policy scene where speakers discussed proposed legislation to change federal energy and environmental policy. Session 2 looked at the future structure of the energy industry, projecting the roles of natural gas, the electric utility industry, and independent power producers in the overall energy system of the 21st century. Session 3 examined current federal policy in research and development as a baseline for discussing the future role of government and industry in supporting research and development. In particular, it looked at the relationship between energy research and development and global competitiveness. Finally, Session 4 attempted to tie these issues together and consider the impact of national policy change on Illinois and the Midwest.

  4. Twenty-Year Survey of Scientific Literacy and Attitudes Toward Science: Students’ Acceptance of Astrology and Pseudoscience

    Science.gov (United States)

    Sugarman, Hannah R.; Impey, C.; Buxner, S.; Antonellis, J.

    2010-01-01

    Our survey used to collect data during a twenty-year long investigation into the science literacy of undergraduates (see Impey et al., this meeting), contains several questions addressing how students conceptualize astrology, and other pseudoscientific ideas. This poster presents findings from the quantitative analysis of some of these question responses from almost 10,000 undergraduate students enrolled in introductory astronomy courses from 1989 to 2009. The results from our data reveal that a large majority of students (78%) and half of science majors (52%) consider astrology either "very” or "sort of” scientific. Students performed comparatively better on all other pseudoscientific questions, demonstrating that belief in astrology is pervasive and deeply entrenched. We compare our results to those obtained by the NSF Science Indicators series, and suggest possible reasons for the high susceptibility to belief in astrology. These findings call into question whether our education system is adequately preparing students to be scientifically literate adults. You can help! Stop by our poster and fill out a new survey that will give us important parallel information to help us continue to analyze our valuable data set. We acknowledge the NSF for funding under Award No. 0715517, a CCLI Phase III Grant for the Collaboration of Astronomy Teaching Scholars (CATS) Program.

  5. Casing study

    Energy Technology Data Exchange (ETDEWEB)

    Roche, P.

    2000-12-01

    An unorthodox method of casing drilling used by Tesco Corporation at a gas well in Wyoming to drill deeper using casings as drillpipe is discussed. The process involves either rotating the casing as drill string or using a downhole mud motor to rotate the bit. In this instance, the surface hole and the production hole were casing-drilled to a record 8,312 feet by rotating the casing. The 8 1/2-inch surface hole was drilled with 7-inch casing to 1,200 feet using a Tesco underreamer and a polycrystalline pilot bit; drilling and cementing was completed in 12 1/2 hours. The 6 1/4-inch production hole was drilled with 4 1/2-inch casing and the bottomhole assembly was retrieved after 191 hours rotating. This case was the first in which the entire well was casing-drilled from surface to TD. Penetration rate compared favorably with conventional methods: 12 1/2 hours for casing-drilling to 18.9 hours for conventional drilling, despite the fact that the casing-drilling technology is still in its infancy. It is suggested that casing-drilling has the potential to eliminate the need for the drillpipe entirely. If these expectations were to be realised, casing-drilling could be one of the most radical drilling changes in the history of the oil and gas industry. 1 photo.

  6. A gold nanoparticle-based semi-quantitative and quantitative ultrasensitive paper sensor for the detection of twenty mycotoxins

    Science.gov (United States)

    Kong, Dezhao; Liu, Liqiang; Song, Shanshan; Suryoprabowo, Steven; Li, Aike; Kuang, Hua; Wang, Libing; Xu, Chuanlai

    2016-02-01

    A semi-quantitative and quantitative multi-immunochromatographic (ICA) strip detection assay was developed for the simultaneous detection of twenty types of mycotoxins from five classes, including zearalenones (ZEAs), deoxynivalenols (DONs), T-2 toxins (T-2s), aflatoxins (AFs), and fumonisins (FBs), in cereal food samples. Sensitive and specific monoclonal antibodies were selected for this assay. The semi-quantitative results were obtained within 20 min by the naked eye, with visual limits of detection for ZEAs, DONs, T-2s, AFs and FBs of 0.1-0.5, 2.5-250, 0.5-1, 0.25-1 and 2.5-10 μg kg-1, and cut-off values of 0.25-1, 5-500, 1-10, 0.5-2.5 and 5-25 μg kg-1, respectively. The quantitative results were obtained using a hand-held strip scan reader, with the calculated limits of detection for ZEAs, DONs, T-2s, AFs and FBs of 0.04-0.17, 0.06-49, 0.15-0.22, 0.056-0.49 and 0.53-1.05 μg kg-1, respectively. The analytical results of spiked samples were in accordance with the accurate content in the simultaneous detection analysis. This newly developed ICA strip assay is suitable for the on-site detection and rapid initial screening of mycotoxins in cereal samples, facilitating both semi-quantitative and quantitative determination.A semi-quantitative and quantitative multi-immunochromatographic (ICA) strip detection assay was developed for the simultaneous detection of twenty types of mycotoxins from five classes, including zearalenones (ZEAs), deoxynivalenols (DONs), T-2 toxins (T-2s), aflatoxins (AFs), and fumonisins (FBs), in cereal food samples. Sensitive and specific monoclonal antibodies were selected for this assay. The semi-quantitative results were obtained within 20 min by the naked eye, with visual limits of detection for ZEAs, DONs, T-2s, AFs and FBs of 0.1-0.5, 2.5-250, 0.5-1, 0.25-1 and 2.5-10 μg kg-1, and cut-off values of 0.25-1, 5-500, 1-10, 0.5-2.5 and 5-25 μg kg-1, respectively. The quantitative results were obtained using a hand-held strip scan

  7. Twenty years of research on water management issues in the Danube Macro-region - past developments and future directions.

    Science.gov (United States)

    Feldbacher, Eva; Paun, Mihaela; Reckendorfer, Walter; Sidoroff, Manuela; Stanica, Adrian; Strimbu, Bogdan; Tusa, Iris; Vulturescu, Viorel; Hein, Thomas

    2016-12-01

    The Danube River-Danube Delta-Black Sea (DBS) region has witnessed major political, social and economic changes during the past three decades, which have profoundly affected the riverine, coastal and marine systems, their water management situation and the development of related research programmes. We reviewed the research activities in the DBS system of the past twenty years to determine the main funding bodies and to assess key research areas and how they varied over time and geographic region. As data basis we used a metadatabase filled with 478 projects addressing environmental and water management issues in the Danube River Basin, covering also the Danube Delta and the north-western Black Sea. As overall outcome extensive research efforts in the field of water management could be proven for the past two decades, despite the tumultuous times of political and economic transformations. One of the main findings was that EU funded projects played a key role for the development of transboundary research collaboration and were also the scientifically most productive one's. Historically, nutrient pollution was the main problem addressed, shifting to pollution in a broader sense and hydromorphological alterations in recent years. The newly arising challenges of climate change impacts and sediment management became important research questions in the last years, too. Most research was performed in the thematic field of navigation, followed by restoration and biodiversity issues. To meet all of the already identified and newly emerging challenges in the DBS System, cross-border and integrated (river-delta-sea) research activities are of major importance and have to be further promoted. We thus suggest drawing up a regional DBS Research Agenda linked to key challenges in water management to strengthen research collaboration and advance targeted scientific projects, an approach fostering also the scientific capacity in the region. Copyright © 2015 Elsevier B.V. All

  8. Screening of antiangiogenic potential of twenty two marine invertebrate extracts of phylum Mollusca from South East Coast of India

    Science.gov (United States)

    Gupta, Pankaj; Arumugam, Muthuvel; Azad, Raj Vardhan; Saxena, Rohit; Ghose, Supriyo; Biswas, Nihar Ranjan; Velpandian, Thirumurthy

    2014-01-01

    Objective To evaluate the antiangiogenic potential of twenty two marine invertebrate species of Phylum Mollusca from south east coast of India. Methods Live specimens of molluscan species were collected and their methanolic extracts were evaluated for preliminary antiangiogenic activity using the in ovo chick chorio-allantoic membrane assay. The extracts were further evaluated for in vivo antiangiogenic activity using chemical cautery induced corneal neovascularization assay in rats and oxygen induced retinopathy assay in rat pups. Results In the chick chorio-allantoic membrane assay, four methanolic extracts of marine molluscan species viz. Meretrix meretrix, Meretrix casta, Telescopium telescopium and Bursa crumena methanolic extracts exhibited noticeable antiangiogenic activity at the tested concentration of 200 µg whereby they significantly inhibited the VEGF induced proliferation of new blood vessels. Among these four extracts, the methanolic extract of Meretrix casta exhibited relatively higher degree of antiangiogenic activity with an inhibitiory percentage (64.63%) of the VEGF induced neovascularization followed by the methanolic extracts of Telescopium telescopium (62.02%), Bursa crumena (60.48%) and Meretrix meretrix (47.01%). These four methanolic extracts were further evaluated for in vivo antiangiogenic activity whereby the methanolic extract of Telescopium telescopium exhibited most noticeable inhibition (42.58%) of the corneal neovascularization in rats in comparison to the sham treated group, and also exhibited most noticeable inhibition (31.31%) of the oxygen induced retinal neovascularization in rat pups in comparison to the hyperoxia group that was observed for considerable retinal neovascularization. Conclusions The significant antiangiogenic activity evinced by the extract of Telescopium telescopium merits further investigation for ocular neovascular diseases. PMID:25183067

  9. Work-related health factors among female immigrants in Sweden - A qualitative study on a sample of twenty workers

    Directory of Open Access Journals (Sweden)

    Sharareh Akhavan

    2006-03-01

    Full Text Available

    Aims: The purpose of this study was to explore work-related health factors amongst female immigrants in Sweden.

    Methods: Qualitative methods were used in order to get the broadest possible picture of female immigrants’ perceptions on work-related health factors. Semi-structured interviews were conducted with twenty female immigrants who worked in different departments of a municipality adjacent to a large city in Sweden. Most of the interviewed women came from the Middle East, Africa and Latin America, while some came from eastern and southern Europe as well as Finland. The women had lived in Sweden for 5-27 years. Content analysis, which is based on analysis by topic, was used to analyse the data.

    Results: Results from the interviews show that female immigrants perceived that work-related health is strongly associated with class. The three aspects of class that arose from this study were wage, professional status and their position within the organisations hierarchy. Other factors that were identified as being associated to work-related health were discrimination due to ethnicity and gender, unfavourable physical and psychosocial work environment and lack of training opportunities for upgrading their skills.

    Conclusions: The public health implications of the findings in this study suggest that measures that ought to be taken to improve female immigrants working conditions and health are primarily systematic efforts to counteract discrimination because of gender and ethnicity in areas such as wage setting and opportunities for skill up-grade training. This should result in improved employment opportunities for female immigrants, particularly those who work in low status and low-paid jobs.

  10. Screening of antiangiogenic potential of twenty two marine invertebrate extracts of phylum Mollusca from South East Coast of India.

    Science.gov (United States)

    Gupta, Pankaj; Arumugam, Muthuvel; Azad, Raj Vardhan; Saxena, Rohit; Ghose, Supriyo; Biswas, Nihar Ranjan; Velpandian, Thirumurthy

    2014-05-01

    To evaluate the antiangiogenic potential of twenty two marine invertebrate species of Phylum Mollusca from south east coast of India. Live specimens of molluscan species were collected and their methanolic extracts were evaluated for preliminary antiangiogenic activity using the in ovo chick chorio-allantoic membrane assay. The extracts were further evaluated for in vivo antiangiogenic activity using chemical cautery induced corneal neovascularization assay in rats and oxygen induced retinopathy assay in rat pups. In the chick chorio-allantoic membrane assay, four methanolic extracts of marine molluscan species viz. Meretrix meretrix, Meretrix casta, Telescopium telescopium and Bursa crumena methanolic extracts exhibited noticeable antiangiogenic activity at the tested concentration of 200 µg whereby they significantly inhibited the VEGF induced proliferation of new blood vessels. Among these four extracts, the methanolic extract of Meretrix casta exhibited relatively higher degree of antiangiogenic activity with an inhibitiory percentage (64.63%) of the VEGF induced neovascularization followed by the methanolic extracts of Telescopium telescopium (62.02%), Bursa crumena (60.48%) and Meretrix meretrix (47.01%). These four methanolic extracts were further evaluated for in vivo antiangiogenic activity whereby the methanolic extract of Telescopium telescopium exhibited most noticeable inhibition (42.58%) of the corneal neovascularization in rats in comparison to the sham treated group, and also exhibited most noticeable inhibition (31.31%) of the oxygen induced retinal neovascularization in rat pups in comparison to the hyperoxia group that was observed for considerable retinal neovascularization. The significant antiangiogenic activity evinced by the extract of Telescopium telescopium merits further investigation for ocular neovascular diseases.

  11. Growth of Global Publishing Output of Health Economics in the Twenty-First Century: A Bibliographic Insight.

    Science.gov (United States)

    Jakovljevic, Mihajlo Michael; Pejcic, Ana V

    2017-01-01

    Strong growth of interdisciplinary sciences might find exceptional example in academic health economics. We decided to observe the quantitative output in this science since the beginning of the twenty-first century. Electronic search of the published literature was conducted in four different databases: one medical database-MEDLINE/PubMed, two general databases-Scopus/Elsevier and Web of Science (WoS), and one specialized health economic database-NHS Economic Evaluation Database (EED). The applied combination of key words was carefully chosen to cover the most commonly used terms in titles of publications dealing with conceptual areas of health economics. All bibliographic units were taken into account. Within the time horizon from January 1, 2000 to December 31, 2016, without language or limitations on bibliographic unit types, we identified an output ranging approximately from 60,345 to 88,246 records with applied search strategy in MEDLINE/PubMed, Scopus/Elsevier, and WoS. In NHS EED, we detected 14,761 records of economic evaluations of health interventions during the period in which database was maintained and regularly updated. With slightly more than one-third of the identified records, USA clearly dominates in this field. United Kingdom takes a strong second place with about 12% of identified records. Consistently, USA and UK universities are the most frequent among the top 15 affiliations/organizations of the authors of the identified records. Authors from Harvard University contributed to the largest number of the identified records. There is a clear evidence of both the upward stream of blossoming in health economics publications and its acceleration. Based on this bibliographic data set, it is difficult to distinguish the actual impact growth of this output provided dominantly by academia with modest contribution by pharmaceutical/medicinal device industry and diverse national government-based agencies. Further insight into the citation track record of

  12. Predicting the patterns of change in spring onset and false springs in China during the twenty-first century.

    Science.gov (United States)

    Zhu, Likai; Meng, Jijun; Li, Feng; You, Nanshan

    2017-10-28

    Spring onset has generally shifted earlier in China over the past several decades in response to the warming climate. However, future changes in spring onset and false springs, which will have profound effects on ecosystems, are still not well understood. Here, we used the extended form of the Spring Indices model (SI-x) to project changes in the first leaf and first bloom dates, and predicted false springs for the historical (1950-2005) and future (2006-2100) periods based on the downscaled daily maximum/minimum temperatures under two emission scenarios from 21 General Circulation Models (GCMs) of the Coupled Model Intercomparison Project Phase 5 (CMIP5). On average, first leaf and first bloom in China were projected to occur 21 and 23 days earlier, respectively, by the end of the twenty-first century in the Representative Concentration Pathway (RCP) 8.5 scenario. Areas with greater earlier shifts in spring onset were in the warm temperate zone, as well as the north and middle subtropical zones of China. Early false spring risk increased rapidly in the warm temperate and north subtropical zones, while that declined in the cold temperate zone. Relative to early false spring risk, late false spring risk showed a common increase with smaller magnitude in the RCP 8.5 scenario but might cause greater damage to ecosystems because plants tend to become more vulnerable to the later occurrence of a freeze event. We conclude that future climate warming will continue to cause earlier occurrence of spring onset in general, but might counterintuitively increase plant damage risk in natural and agricultural systems of the warm temperate and subtropical China.

  13. Predicting the patterns of change in spring onset and false springs in China during the twenty-first century

    Science.gov (United States)

    Zhu, Likai; Meng, Jijun; Li, Feng; You, Nanshan

    2017-10-01

    Spring onset has generally shifted earlier in China over the past several decades in response to the warming climate. However, future changes in spring onset and false springs, which will have profound effects on ecosystems, are still not well understood. Here, we used the extended form of the Spring Indices model (SI-x) to project changes in the first leaf and first bloom dates, and predicted false springs for the historical (1950-2005) and future (2006-2100) periods based on the downscaled daily maximum/minimum temperatures under two emission scenarios from 21 General Circulation Models (GCMs) of the Coupled Model Intercomparison Project Phase 5 (CMIP5). On average, first leaf and first bloom in China were projected to occur 21 and 23 days earlier, respectively, by the end of the twenty-first century in the Representative Concentration Pathway (RCP) 8.5 scenario. Areas with greater earlier shifts in spring onset were in the warm temperate zone, as well as the north and middle subtropical zones of China. Early false spring risk increased rapidly in the warm temperate and north subtropical zones, while that declined in the cold temperate zone. Relative to early false spring risk, late false spring risk showed a common increase with smaller magnitude in the RCP 8.5 scenario but might cause greater damage to ecosystems because plants tend to become more vulnerable to the later occurrence of a freeze event. We conclude that future climate warming will continue to cause earlier occurrence of spring onset in general, but might counterintuitively increase plant damage risk in natural and agricultural systems of the warm temperate and subtropical China.

  14. Agriculture in West Africa in the Twenty-First Century: Climate Change and Impacts Scenarios, and Potential for Adaptation.

    Science.gov (United States)

    Sultan, Benjamin; Gaetani, Marco

    2016-01-01

    West Africa is known to be particularly vulnerable to climate change due to high climate variability, high reliance on rain-fed agriculture, and limited economic and institutional capacity to respond to climate variability and change. In this context, better knowledge of how climate will change in West Africa and how such changes will impact crop productivity is crucial to inform policies that may counteract the adverse effects. This review paper provides a comprehensive overview of climate change impacts on agriculture in West Africa based on the recent scientific literature. West Africa is nowadays experiencing a rapid climate change, characterized by a widespread warming, a recovery of the monsoonal precipitation, and an increase in the occurrence of climate extremes. The observed climate tendencies are also projected to continue in the twenty-first century under moderate and high emission scenarios, although large uncertainties still affect simulations of the future West African climate, especially regarding the summer precipitation. However, despite diverging future projections of the monsoonal rainfall, which is essential for rain-fed agriculture, a robust evidence of yield loss in West Africa emerges. This yield loss is mainly driven by increased mean temperature while potential wetter or drier conditions as well as elevated CO2 concentrations can modulate this effect. Potential for adaptation is illustrated for major crops in West Africa through a selection of studies based on process-based crop models to adjust cropping systems (change in varieties, sowing dates and density, irrigation, fertilizer management) to future climate. Results of the cited studies are crop and region specific and no clear conclusions can be made regarding the most effective adaptation options. Further efforts are needed to improve modeling of the monsoon system and to better quantify the uncertainty in its changes under a warmer climate, in the response of the crops to such

  15. One hundred and twenty-five years of the Annals of Botany. Part 2: the years 1937 to 2012.

    Science.gov (United States)

    Jackson, Michael B

    2016-12-01

    Annals of Botany is a peer-reviewed plant biology journal. It was started in 1887, making it the oldest continuously published plant science title. A previous article [Jackson MB. 2015. One hundred and twenty-five years of the Annals of Botany Part 1: the first 50 years (1887-1936). Annals of Botany 115: : 1-18] summarized events leading to its founding, highlighted the individuals involved and examined the Journal's achievements and management practices over the first 50 years to 1937. This second article covers the next 75 years. The account draws principally on the Journal's own records, minute books, financial accounts, original letters and notes held by the Annals of Botany Company, the Journal's owners and managers. In 1937, its 51st year, the Journal was re-launched as Annals of Botany New Series and its volume numbers were reset to No. I. The present article evaluates the evolution of the New Series up to 2012, Annals of Botany's 125th anniversary year. The period includes a 2-year run-up to World War II, six war years and their immediate aftermath, and then on through increasingly competitive times. The ebb and flow of the Journal's fortunes are set against a roll-call of the often highly distinguished scientists who managed and edited the Journal. The article also examines an internal crisis in the 1980s that radically altered the Journal's organization in ways that were, ultimately, to its benefit. The narrative is set against changes to economic conditions in Great Britain over the period, to the evolving nature and geographical distribution of much experimental plant science and to the digital revolution that, from the late 20th century, transformed the workings of Annals of Botany and of scientific publishing more generally. © The Author 2016. Published by Oxford University Press on behalf of the Annals of Botany Company. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  16. Antioxidant potential of brans of twenty-nine red and white rice (Oryza sativa L. varieties of Sri Lanka

    Directory of Open Access Journals (Sweden)

    Walimuni Kanchana Subhashini Mendis Abeysekera

    2017-11-01

    Full Text Available Objective: To evaluate antioxidant properties of brans of twenty-nine red and white rice varieties of Sri Lanka. Methods: Brans of 21 new improved (NI, 2 old improved (OI and 6 traditional red and white rice varieties of Sri Lanka were studied for range of antioxidant properties. The studied antioxidant properties included total polyphenolic content (TPC, ferric reducing antioxidant power (FRAP, oxygen radical absorbance capacity (ORAC, 2,2’-azino-bis(3- ethylbenzothiazoline-6-sulfonic acid (ABTS radical scavenging activity and 1,1-diphenyl- 2-picrylhydrazine (DPPH radical scavenging activity in vitro. Bran of black rice variety from Korea was also studied for the same antioxidant properties for comparison. Results: Results exhibited significantly high ABTS and DPPH radical scavenging activities and 10, 7 and 2.5 fold greater TPC, FRAP and ORAC activities in brans of red rices (BRRs compared to brans of white rices irrespective of NI, OI and traditional rice types. Among BRRs traditional varieties had greater ABTS and DPPH radical scavenging activities and 1.7, 1.3 and 1.2 fold respectively greater TPC, FRAP and ORAC in contrast to NI red rices. Traditional red rice varieties, Kalu Heeneti (TPC and ORAC, Pachchaperumal (TPC and DPPH and Kurulu Thuda (DPPH and OI red rice variety H4 (FRAP exhibited the highest activities for the antioxidant properties studied. Further, these varieties had significantly high activities compared to black rice. Conclusions: In conclusion, BRRs especially traditional red rices had greater antioxidant properties and consumption may be useful in managing various chronic diseases.

  17. Dietary guidelines to nourish humanity and the planet in the twenty-first century. A blueprint from Brazil.

    Science.gov (United States)

    Monteiro, Carlos Augusto; Cannon, Geoffrey; Moubarac, Jean-Claude; Martins, Ana Paula Bortoletto; Martins, Carla Adriano; Garzillo, Josefa; Canella, Daniela Silva; Baraldi, Larissa Galastri; Barciotte, Maluh; Louzada, Maria Laura da Costa; Levy, Renata Bertazzi; Claro, Rafael Moreira; Jaime, Patrícia Constante

    2015-09-01

    To present and discuss the dietary guidelines issued by the Brazilian government in 2014. The present paper describes the aims of the guidelines, their shaping principles and the approach used in the development of recommendations. The main recommendations are outlined, their significance for the cultural, socio-economic and environmental aspects of sustainability is discussed, and their application to other countries is considered. Brazil in the twenty-first century. All people in Brazil, now and in future. The food- and meal-based Brazilian Dietary Guidelines address dietary patterns as a whole and so are different from nutrient-based guidelines, even those with some recommendations on specific foods or food groups. The guidelines are based on explicit principles. They take mental and emotional well-being into account, as well as physical health and disease prevention. They identify diet as having cultural, socio-economic and environmental as well as biological and behavioural dimensions. They emphasize the benefits of dietary patterns based on a variety of natural or minimally processed foods, mostly plants, and freshly prepared meals eaten in company, for health, well-being and all relevant aspects of sustainability, as well as the multiple negative effects of ready-to-consume ultra-processed food and drink products. The guidelines' recommendations are designed to be sustainable personally, culturally, socially, economically and environmentally, and thus fit to face this century. They are for foods, meals and dietary patterns of types that are already established in Brazil, which can be adapted to suit the climate, terrain and customs of all countries.

  18. Inequalities in cancer incidence and mortality across medium to highly developed countries in the twenty-first century.

    Science.gov (United States)

    Arnold, Melina; Rentería, Elisenda; Conway, David I; Bray, Freddie; Van Ourti, Tom; Soerjomataram, Isabelle

    2016-08-01

    Inequalities in the burden of cancer have been well documented, and a variety of measures exist to analyse disease disparities. While previous studies have focused on inequalities within countries, the aim of the present study was to quantify existing inequalities in cancer incidence and mortality between countries. Data on total and site-specific cancer incidence and mortality in 2003-2007 were obtained for 43 countries with medium-to-high levels of human development via Cancer Incidence in Five Continents Vol. X and the WHO Mortality Database. We calculated the concentration index as a summary measure of socioeconomic-related inequality between countries. Inequalities in cancer burden differed markedly by site; the concentration index for all sites combined was 0.03 for incidence and 0.02 for mortality, pointing towards a slightly higher burden in countries with higher levels of the human development index (HDI). For both incidence and mortality, this pattern was most pronounced for melanoma. In contrast, the burden of cervical cancer was disproportionally high in countries with lower HDI levels. Prostate, lung and breast cancer contributed most to inequalities in overall cancer incidence in countries with higher HDI levels, while for mortality these were mostly driven by lung cancer in higher HDI countries and stomach cancer in countries with lower HDI levels. Global inequalities in the burden of cancer remain evident at the beginning of the twenty-first century: with a disproportionate burden of lifestyle-related cancers in countries classified as high HDI, while infection-related cancers continue to predominate in transitioning countries with lower levels of HDI.

  19. Twenty years of high-resolution sea surface temperature imagery around Australia: inter-annual and annual variability.

    Science.gov (United States)

    Foster, Scott D; Griffin, David A; Dunstan, Piers K

    2014-01-01

    The physical climate defines a significant portion of the habitats in which biological communities and species reside. It is important to quantify these environmental conditions, and how they have changed, as this will inform future efforts to study many natural systems. In this article, we present the results of a statistical summary of the variability in sea surface temperature (SST) time-series data for the waters surrounding Australia, from 1993 to 2013. We partition variation in the SST series into annual trends, inter-annual trends, and a number of components of random variation. We utilise satellite data and validate the statistical summary from these data to summaries of data from long-term monitoring stations and from the global drifter program. The spatially dense results, available as maps from the Australian Oceanographic Data Network's data portal (http://www.cmar.csiro.au/geonetwork/srv/en/metadata.show?id=51805), show clear trends that associate with oceanographic features. Noteworthy oceanographic features include: average warming was greatest off southern West Australia and off eastern Tasmania, where the warming was around 0.6°C per decade for a twenty year study period, and insubstantial warming in areas dominated by the East Australian Current, but this area did exhibit high levels of inter-annual variability (long-term trend increases and decreases but does not increase on average). The results of the analyses can be directly incorporated into (biogeographic) models that explain variation in biological data where both biological and environmental data are on a fine scale.

  20. Uncertainty in twenty-first century projections of the Atlantic Meridional Overturning Circulation in CMIP3 and CMIP5 models

    Science.gov (United States)

    Reintges, Annika; Martin, Thomas; Latif, Mojib; Keenlyside, Noel S.

    2017-09-01

    Uncertainty in the strength of the Atlantic Meridional Overturning Circulation (AMOC) is analyzed in the Coupled Model Intercomparison Project Phase 3 (CMIP3) and Phase 5 (CMIP5) projections for the twenty-first century; and the different sources of uncertainty (scenario, internal and model) are quantified. Although the uncertainty in future projections of the AMOC index at 30°N is larger in CMIP5 than in CMIP3, the signal-to-noise ratio is comparable during the second half of the century and even larger in CMIP5 during the first half. This is due to a stronger AMOC reduction in CMIP5. At lead times longer than a few decades, model uncertainty dominates uncertainty in future projections of AMOC strength in both the CMIP3 and CMIP5 model ensembles. Internal variability significantly contributes only during the first few decades, while scenario uncertainty is relatively small at all lead times. Model uncertainty in future changes in AMOC strength arises mostly from uncertainty in density, as uncertainty arising from wind stress (Ekman transport) is negligible. Finally, the uncertainty in changes in the density originates mostly from the simulation of salinity, rather than temperature. High-latitude freshwater flux and the subpolar gyre projections were also analyzed, because these quantities are thought to play an important role for the future AMOC changes. The freshwater input in high latitudes is projected to increase and the subpolar gyre is projected to weaken. Both the freshening and the gyre weakening likely influence the AMOC by causing anomalous salinity advection into the regions of deep water formation. While the high model uncertainty in both parameters may explain the uncertainty in the AMOC projection, deeper insight into the mechanisms for AMOC is required to reach a more quantitative conclusion.

  1. Twenty Years of High-Resolution Sea Surface Temperature Imagery around Australia: Inter-Annual and Annual Variability

    Science.gov (United States)

    Foster, Scott D.; Griffin, David A.; Dunstan, Piers K.

    2014-01-01

    The physical climate defines a significant portion of the habitats in which biological communities and species reside. It is important to quantify these environmental conditions, and how they have changed, as this will inform future efforts to study many natural systems. In this article, we present the results of a statistical summary of the variability in sea surface temperature (SST) time-series data for the waters surrounding Australia, from 1993 to 2013. We partition variation in the SST series into annual trends, inter-annual trends, and a number of components of random variation. We utilise satellite data and validate the statistical summary from these data to summaries of data from long-term monitoring stations and from the global drifter program. The spatially dense results, available as maps from the Australian Oceanographic Data Network's data portal (http://www.cmar.csiro.au/geonetwork/srv/en/metadata.show?id=51805), show clear trends that associate with oceanographic features. Noteworthy oceanographic features include: average warming was greatest off southern West Australia and off eastern Tasmania, where the warming was around 0.6°C per decade for a twenty year study period, and insubstantial warming in areas dominated by the East Australian Current, but this area did exhibit high levels of inter-annual variability (long-term trend increases and decreases but does not increase on average). The results of the analyses can be directly incorporated into (biogeographic) models that explain variation in biological data where both biological and environmental data are on a fine scale. PMID:24988444

  2. Twenty-four-hour patterns in occurrence and pathophysiology of acute cardiovascular events and ischemic heart disease.

    Science.gov (United States)

    Manfredini, Roberto; Boari, Benedetta; Salmi, Raffaella; Fabbian, Fabio; Pala, Marco; Tiseo, Ruana; Portaluppi, Francesco

    2013-03-01

    The scientific literature clearly establishes the occurrence of cardiovascular (CV) accidents and myocardial ischemic episodes is unevenly distributed during the 24 h. Such temporal patterns result from corresponding temporal variation in pathophysiologic mechanisms and cyclic environmental triggers that elicit the onset of clinical events. Moreover, both the pharmacokinetics and pharmacodynamics of many, though not all, CV medications have been shown to be influenced by the circadian time of their administration, even though further studies are necessary to better clarify the mechanisms of such influence on different drug classes, drug molecules, and pharmaceutical preparations. Twenty-four-hour rhythmic organization of CV functions is such that defense mechanisms against acute events are incapable of providing the same degree of protection during the day and night. Instead, temporal gates of excessive susceptibility exist, particularly in the morning and to a lesser extent evening (in diurnally active persons), to aggressive mechanisms through which overt clinical manifestations may be triggered. When peak levels of critical physiologic variables, such as blood pressure (BP), heart rate (HR), rate pressure product (systolic BP × HR, surrogate measure of myocardial oxygen demand), sympathetic activation, and plasma levels of endogenous vasoconstricting substances, are aligned together at the same circadian time, the risk of acute events becomes significantly elevated such that even relatively minor and usually harmless physical and mental stress and environmental phenomena can precipitate dramatic life-threatening clinical manifestations. Hence, the delivery of CV medications needs to be synchronized in time, i.e., circadian time, in proportion to need as determined by established temporal patterns in risk of CV events, and in a manner that averts or minimizes undesired side effects.

  3. Sporotriciiosis study of 22 cases from Himachal Pradesh

    Directory of Open Access Journals (Sweden)

    N L Sharma

    1990-01-01

    Full Text Available Twenty two cases of sporotrichosis recorded in 15 years span are discussed. Geographic distribution of the disease in various regions of the country are identified. The clinico-investigative profile of the patients is discussed. An uncommon extracutaneous form having osteomyelitic changes of phalangeal bones in a 14 year old boy is also described.

  4. Surgical treatment of hyperparathyroidism : with an analysis of 267 cases

    NARCIS (Netherlands)

    H.A. Bruining (Hajo)

    1971-01-01

    textabstractIt is generally accepted that for autonomous hyperparathyroidism, whether primary or tertiary, surgery is still the only suitable method of treatment available. Analysis of a series of cases treated in t his way over the past twenty years has shown that there are certain problems

  5. Cerebellar Haemangioblastoma in Pregnancy: A Report of 2 Cases ...

    African Journals Online (AJOL)

    Haemangioblastoma is a relatively uncommon vascular tumour, usually occurring in the cerebellum. Twenty-eight cases of cerebellar haemangioblastoma in pregnancy have previously been described in the literature. It has been suggested that the hormonal and vascular changes of pregnancy have been associated with ...

  6. Case report: Ichthiosis bullosa of Siemens | Ahmed | Sudanese ...

    African Journals Online (AJOL)

    A case of ichthiosis bullosa of Siemens is described in a twenty-five years old Sudanese female. Review of this condition concerning genetics, molecular biology, histopathology and clinical picture is added. Sudanese Journal of Dermatology Vol. 3(2) 2005: 96-98 ...

  7. Case report

    African Journals Online (AJOL)

    ebutamanya

    2015-02-12

    Feb 12, 2015 ... Abstract. Vaginal metastasis from pancreatic cancer is an extreme case and often indicates a poor prognosis. We present a case of pancreatic carcinoma with metastasis to the vagina that was discovered by vaginal bleeding. To our knowledge, this is the third case in the world of a primary pancreatic.

  8. Case Report

    African Journals Online (AJOL)

    usually occurs with high intravenous steroid doses. More significant arrhythmias and cardiac arrest were also described. In this report we describe a case of bradycardia that developed after the use of oral corticosteroids. Case report: We report a case of bradycardia that developed in a 14 year-old male after receiving oral.

  9. Case series

    African Journals Online (AJOL)

    abp

    2017-07-13

    Jul 13, 2017 ... calcium channel blockers. In case of supraventricular rhythm disorder, amiodarone is associated. The definitive pacemaker or cardiac defibrillator implantation is performed on a case by case basis according to the complications or associated risks. Post-septal alcoholization follow-up is done at one month ...

  10. PRIMARY PULMONARY CHORIOCARCINOMA – CASE REPORT

    Directory of Open Access Journals (Sweden)

    Biljana Lazović

    2010-12-01

    Full Text Available Literature has described only twenty-two cases of primary pulmonary choriocarcinoma. Unlike gestational choriocarcinoma which responds well to chemotherapy and has good prognosis, even in cases when detected later, pulmonary choriocarcinoma leads rapidly to fatal outcome. The reason is unknown. This paper presents a case of thirty-four-old young woman with clinical presentation of cough, expectoration, occasionally with hemoptisis, pleural pain, lack of breath and fever, with laboratory findings of pleural effusion on the left, which was treated as a case of tuberculosis for three months. Gynecological finding was regular. Progressive, rapid deterioration of general condition, degree of dispnea, hemoptisis episode led to respiratory failure before having appied the appropriate therapy. In cases of haemoptisis, one should think about this rare malignant entity and check the level of human chorionic gonadotropin in women.

  11. Nursing as a Profession in the Twenty-First Century : An oral presentation at the Fourth Seminar for Presidents of Junior and Community Colleges

    OpenAIRE

    Tokugoro, TSUNEMATSU

    2000-01-01

    The Fourth Seminar for Presidents of Junior and Community entitled Meeting the Challenges of Higher Education in the Twenty-First Century was held on June 21-22, 1999 in Honolulu, Hawaii. The author had a chance to speak under the title of Nursing as a Profession in the Twenty-First Century at a session of Nursing Profession: Changes for the Next Millennium, first presenting the social trends surrounding medical and nursing care in Shimane as well as in Japan, and then details of the establis...

  12. A Twenty-Year Look at “Computational Geology,” an Evolving, In-Discipline Course in Quantitative Literacy at the University of South Florida

    Directory of Open Access Journals (Sweden)

    Victor J. Ricchezza

    2017-01-01

    Full Text Available Since 1996, the Geology (GLY program at the USF has offered “Computational Geology” as part of its commitment to prepare undergraduate majors for the quantitative aspects of their field. The course focuses on geological-mathematical problem solving. Over its twenty years, the course has evolved from a GATC (geometry-algebra-trigonometry-calculus in-discipline capstone to a quantitative literacy (QL course taught within a natural science major. With the formation of the new School of Geosciences in 2013, the merging departments re-examined their various curricular programs. An online survey of the Geology Alumni Society found that “express quantitative evidence in support of an argument” was more favorably viewed as a workplace skill (4th out of 69 than algebra (51st, trig (55th and calculus 1 and 2 (59th and 60th. In that context, we decided to find out from successful alumni, “What did you get out of Computational Geology?” To that end, the first author carried out a formal, qualitative research study (narrative inquiry protocol, whereby he conducted, recorded, and transcribed semi-structured interviews of ten alumni selected from a list of 20 provided by the second author. In response to “Tell me what you remember from the course,” multiple alumni volunteered nine items: Excel (10 out of 10, Excel modules (8, Polya problem solving (5, “important” (4, unit conversions (4, back-of-the-envelope calculations (4, gender equality (3. In response to “Is there anything from the course that you used professionally or personally since graduating?” multiple alumni volunteered seven items: Excel (9 out of 10, QL/thinking (6, unit conversions (5, statistics (5, Excel modules (3, their notes (2. Outcome analysis from the open-ended comments arising from structured questions led to the identification of alumni takeaways in terms of elements of three values: (1 understanding and knowledge (facts such as conversion factors, and concepts

  13. Missionaries, Anthropologists, and Cultural Change [Part I]. Studies in Third World Societies. Publication Number Twenty-Five.

    Science.gov (United States)

    Whiteman, Darrell L., Ed.

    The topics of anthropologist-missionary relationships, theology and missiology, research methods and missionary contributions to ethnology, and missionary training and methods, along with specific case studies are presented. The 13 essays are: (1) "Prospects for a Better Understanding and Closer Cooperation between Anthropologists and…

  14. Twenty years' delay of fellow eye involvement in herpes simplex virus type 2-associated bilateral acute retinal necrosis syndrome

    NARCIS (Netherlands)

    Schlingemann, R. O.; Bruinenberg, M.; Wertheim-van Dillen, P.; Feron, E.

    1996-01-01

    PURPOSE: To describe a case of acute retinal necrosis with concurrent encephalitis and determine the causative virus. The patient had a history of presumed acute retinal necrosis in the left eye at the age of 8 years and recurrent genital herpes. METHODS: Diagnostic anterior chamber puncture of the

  15. The twenty-third report on survey of the adverse reaction to radiopharmaceuticals (The 26th survey in 2000)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-02-01

    The survey in the title involves occasions of adverse reactions and drug defects of radiopharmaceuticals and its 26th one in 2000 (April 1, 2000-March 31, 2001) is reported herein. The survey was conducted by questionnaire to 1,212 facilities, of which 1,044 (86.1%) answered. Adverse reaction (24 cases/1,401,962 in total cases of administration=0.0017% occasion) and drug defect (3 cases, 0.0002%) were reported from 25 facilities: They were 0.0017-0.0025% and 0.0001-0.0006%, respectively, after 1996. Most frequent occasion (203/100,000 examinations) of adverse reaction was seen in {sup 131}I-methyl-norcholesterol, which had been considered to be due to the ingredient, ethanol. Occasion of the adverse reaction of other drugs were less than 47/100,000 examinations. Three cases of the drug defect were poor distribution (2) ({sup 99m}Tc-HMDP) and poor labeling (1) ({sup 99m}Tc-tetrofosmin). (K.H.)

  16. Linear lichen planus in children - Case report*

    Science.gov (United States)

    Horowitz, Marcia Raquel; Vidal, Marcela de Lima; Resende, Manuela Oliveira; Teixeira, Márcia Almeida Galvão; Cavalcanti, Silvana Maria de Morais; de Alencar, Eliane Ruth Barbosa

    2013-01-01

    Lichen planus is an uncommon disease in children, and only 2 to 3% of affected patients are under twenty years of age. This dermatosis may appear in several clinical forms, which vary according to the morphology and distribution of lesions. In less than 0.2% of all lichen planus cases, the lesions are distributed along the lines of Blaschko, and is a variant called linear lichen planus. This is a case report of a patient aged two years and eight months, who presented keratotic violaceous papules, affecting the abdomen, buttocks and right thigh, distributed along the lines of Blaschko. Histopathological examination confirmed a diagnosis of linear lichen planus. PMID:24346902

  17. Soft tissue management of children's open tibial fractures – a review of seventy children over twenty years

    Science.gov (United States)

    Rao, P; Schaverien, MV; Stewart, KJ

    2010-01-01

    INTRODUCTION The management of open tibial fractures in children represents a unique reconstructive challenge. The aim of the study was to evaluate the management of paediatric open tibial fractures with particular regard to soft tissue management. PATIENTS AND METHODS A retrospective case-note analysis was performed for all children presenting with an open tibial fracture at a single institution over a 20-year period for 1985 to 2005. RESULTS Seventy children were reviewed of whom 41 were males and 29 females. Overall, 91% (n = 64) of children suffered their injury as a result of a vehicle-related injury. The severity of the fracture with respect to the Gustilo classification was: Grade I, 42% (n = 29); Grade II, 24% (n = 17); Grade III, 34% (n = 24; 7 Grade 3a, 16 Grade 3b, 1 Grade 3c). The majority of children were treated with external fixation and conservative measures, with a mean hospital in-patient stay of 13.3 days. Soft tissue cover was provided by plastic surgeons in 31% of all cases. Four cases of superficial wound infection occurred (6%), one case of osteomyelitis and one case of flap failure. The limb salvage was greater than 98%. CONCLUSIONS In this series, complications were associated with delayed involvement of plastic surgeons. Retrospective analysis has shown a decreased incidence of open tibial fractures which is reported in similar studies. Gustilo grade was found to correlate with length of hospital admission and plastic surgery intervention. We advocate, when feasible, the use of local fas-ciocutaneous flaps (such as distally based fasciocutaneous and adipofascial flaps), which showed a low complication rate in children. PMID:20501017

  18. Training medical students for the twenty-first century: Rationale and development of the Utrecht curriculum "CRU+".

    Science.gov (United States)

    Ten Cate, Olle; Borleffs, Jan; van Dijk, Marijke; Westerveld, Tineke

    2018-02-22

    committed to developing training to meet twenty-first century demands of medical graduates.

  19. Growth of Global Publishing Output of Health Economics in the Twenty-First Century: A Bibliographic Insight

    Directory of Open Access Journals (Sweden)

    Mihajlo (Michael Jakovljevic

    2017-08-01

    Full Text Available BackgroundStrong growth of interdisciplinary sciences might find exceptional example in academic health economics. We decided to observe the quantitative output in this science since the beginning of the twenty-first century.MethodsElectronic search of the published literature was conducted in four different databases: one medical database—MEDLINE/PubMed, two general databases—Scopus/Elsevier and Web of Science (WoS, and one specialized health economic database—NHS Economic Evaluation Database (EED. The applied combination of key words was carefully chosen to cover the most commonly used terms in titles of publications dealing with conceptual areas of health economics. All bibliographic units were taken into account.ResultsWithin the time horizon from January 1, 2000 to December 31, 2016, without language or limitations on bibliographic unit types, we identified an output ranging approximately from 60,345 to 88,246 records with applied search strategy in MEDLINE/PubMed, Scopus/Elsevier, and WoS. In NHS EED, we detected 14,761 records of economic evaluations of health interventions during the period in which database was maintained and regularly updated. With slightly more than one-third of the identified records, USA clearly dominates in this field. United Kingdom takes a strong second place with about 12% of identified records. Consistently, USA and UK universities are the most frequent among the top 15 affiliations/organizations of the authors of the identified records. Authors from Harvard University contributed to the largest number of the identified records.ConclusionThere is a clear evidence of both the upward stream of blossoming in health economics publications and its acceleration. Based on this bibliographic data set, it is difficult to distinguish the actual impact growth of this output provided dominantly by academia with modest contribution by pharmaceutical/medicinal device industry and diverse national government

  20. Zoos in the twenty-first century: Can't we find a better way to love nature?

    Science.gov (United States)

    Dewey-Platt, Lauren Kay

    As a new millennium approaches, many forms of life on the planet and the environments in which they have evolved are increasingly threatened by human activities Wildlife is being marginalized, and native habitats are disappearing at an unprecedented rate. Equally disturbing is the impending demise of traditional human societies---peoples who have evolved outside of the confines and conditions of modern Western influence. The loss of these human and animal societies has occurred so rapidly that implications are largely unknown. Research on how modern Americans relate to animals, particularly wildlife, revealed a clear and disturbing incongruity best exemplified in the current paradigm of zoo exhibition and education. Although zoos purport to educate visitors about the ecology of natural environments and the universal plight of wildlife, research shows that people, particularly children, learn less about ecological principles in zoos with live animals than they do in non-living natural history exhibits. While designers employ a variety of visual techniques in natural history exhibition, environmental sound as an educational exhibit component is largely nonexistent. Many animal species communicate through sound, especially species in underwater environments. As the audio equivalent of a landscape, the soundscape is as important as any other habitat feature to the well-being of wildlife populations. Using recorded sounds of natural environments, an exhibition soundscape was designed and produced for Oceanario de Lisboa in Lisbon, Portugal---the centerpiece of the 1998 World Exposition in Lisbon, Portugal. With programmed sound serving as a major component of natural history exhibition, a conceptual design of a novel zoo for the twenty-first century was described. The "NewZew" concept is based on a growing awareness that the best way to save species is to salvage, preserve, and restore their natural habitats---activities that are largely antithetical to current zoo

  1. Music Education in the Twenty-First Century: A Cross-Cultural Comparison of German and American Music Education towards a New Concept of International Dialogue

    Science.gov (United States)

    Kertz-Welzel, Alexandra

    2008-01-01

    Comparative Music Education is often considered to be an unnecessary subject because there seem to be more important issues for research than studying music education in various countries. Comparative music education is not a luxury, but rather a necessity in the twenty-first century. Scholars and music teachers in many countries are struggling…

  2. Twenty-third Semiannual Report of the Commission to the Congress, January 1958. Progress in peaceful uses of atomic energy July - December 1957

    Energy Technology Data Exchange (ETDEWEB)

    Strauss, Lewis L.

    1958-01-31

    The document represents the twenty-third semiannual Atomic Energy Commission (AEC) report to Congress. The report sums up the major activities and developments in the national atomic energy program covering the period July - December 1957. A special part one of this semiannual report is titled ''Progress in the Peaceful Uses of Atomic Energy - A 3-year Summary.

  3. Twenty Five Years in Cheminformatics - A Career Path Through a Diverse Series of Roles and Responsibilities (INVITED TALK) (ACS Spring meeting)

    Science.gov (United States)

    Antony Williams is a Computational Chemist at the US Environmental Protection Agency in the National Center for Computational Toxicology. He has been involved in cheminformatics and the dissemination of chemical information for over twenty-five years. He has worked for a Fortune ...

  4. Sea-level rise and its possible impacts given a ‘beyond 4°C world’ in the twenty-first century

    NARCIS (Netherlands)

    Nicholls, R.; Marinova, N.A.; Lowe, J.; Brown, S.; Vellinga, P.

    2011-01-01

    The range of future climate-induced sea-level rise remains highly uncertain with continued concern that large increases in the twenty-first century cannot be ruled out. The biggest source of uncertainty is the response of the large ice sheets of Greenland and west Antarctica. Based on our analysis,

  5. High School Students' Perceptions of the Effects of International Science Olympiad on Their STEM Career Aspirations and Twenty-First Century Skill Development

    Science.gov (United States)

    Sahin, Alpaslan; Gulacar, Ozcan; Stuessy, Carol

    2015-01-01

    Social cognitive theory guided the design of a survey to investigate high school students' perceptions of factors affecting their career contemplations and beliefs regarding the influence of their participation in the international Science Olympiad on their subject interests and twenty-first century skills. In addition, gender differences in…

  6. Relative Citation Ratio of Top Twenty Macedonian Biomedical Scientists in PubMed: A New Metric that Uses Citation Rates to Measure Influence at the Article Level.

    Science.gov (United States)

    Spiroski, Mirko

    2016-06-15

    The aim of this study was to analyze relative citation ratio (RCR) of top twenty Macedonian biomedical scientists with a new metric that uses citation rates to measure influence at the article level. Top twenty Macedonian biomedical scientists were identified by GoPubMed on the base of the number of deposited abstracts in PubMed, corrected with the data from previously published paper, and completed with the Macedonian biomedical scientists working in countries outside the Republic of Macedonia, but born or previously worked in the country. iCite was used as a tool to access a dashboard of bibliometrics for papers associated with a portfolio. The biggest number of top twenty Macedonian biomedical scientists has RCR lower than one. Only four Macedonian biomedical scientists have bigger RCR in comparison with those in PubMed. The most prominent RCR of 2.29 has Rosoklija G. RCR of the most influenced individual papers deposited in PubMed has shown the biggest value for the paper of Efremov D (35.19). This paper has the biggest number of authors (860). It is necessary to accept top twenty Macedonian biomedical scientists as an example of new metric that uses citation rates to measure influence at the article level, rather than qualification of the best Macedonian biomedical scientists.

  7. Culturally Relevant Pedagogy Twenty-Plus Years Later: How an Arts Approach to Teaching and Learning Can Keep the Dream Alive

    Science.gov (United States)

    McCarther, Shirley Marie; Davis, Donna M.

    2017-01-01

    Gloria Ladson-Billings' (1995) ground-breaking work around the theory of culturally relevant pedagogy has shaped the discourse in schools and education programs for over twenty years. Her belief that schools should be places where students and teachers come together to have meaningful educational experiences has provided a foundation for…

  8. Early Mental Development as a Predictor of Preschool Cognitive and Behavioral Development in South Africa: The Moderating Role of Maternal Education in the Birth to Twenty Cohort

    Science.gov (United States)

    Hsiao, Celia; Richter, Linda M.

    2014-01-01

    This article examines the influence of early development on preschool cognitive and behavioral outcomes in South Africa, as well as the role of family factors such as maternal education in moderating this association. The study involved 167 Black South African children (89 boys and 78 girls) from the Birth to Twenty study during their first 5…

  9. Solving the problems we face: the United States Environmental Protection Agency, sustainability, and the challenges of the twenty-first century

    Science.gov (United States)

    Addressing the problems of the twenty-first century will require new initiatives that complement traditional regulatory activities. Existing regulations, such as the Clean Air Act and Clean Water Act are important safety nets in the United States for protecting human health and t...

  10. Bruce's Magnificent Quartet: Inquiry, Community, Technology and Literacy--Implications for Renewing Qualitative Research in the Twenty-First Century

    Science.gov (United States)

    Davidson, Judith

    2014-01-01

    Bruce and Bishop's community informatics work brings forward four critical concepts: inquiry, community, technology, and literacy. These four terms serve as the basis for a discussion of qualitative research in the twenty-first century--what is lacking and what is needed. The author suggests that to resolve the tensions or challenges…

  11. Sensitivity of discharge and flood frequency to twenty-first century and late Holocene changes in climate and land use (River Meuse, northwest Europe)

    NARCIS (Netherlands)

    Ward, P.J.; Renssen, H.; Aerts, J.C.J.H.; Verburg, P.H.

    2011-01-01

    We used a calibrated coupled climate–hydrological model to simulate Meuse discharge over the late Holocene (4000–3000 BP and 1000–2000 AD). We then used this model to simulate discharge in the twenty-first century under SRES emission scenarios A2 and B1, with and without future land use change. Mean

  12. Reaching a Consensus on the Definition of Genetic Literacy that Is Required from a Twenty-First-Century Citizen

    Science.gov (United States)

    Boerwinkel, Dirk Jan; Yarden, Anat; Waarlo, Arend Jan

    2017-12-01

    To determine what knowledge of genetics is needed for decision-making on genetic-related issues, a consensus-reaching approach was used. An international group of 57 experts, involved in teaching, studying, or developing genetic education and communication or working with genetic applications in medicine, agriculture, or forensics, answered the questions: "What knowledge of genetics is relevant to those individuals not professionally involved in science?" and "Why is this knowledge relevant?" The answers were classified in different knowledge components following the PISA 2015 science framework. During a workshop with the participants, the results were discussed and applied to seven cases in which genetic knowledge is relevant for decision-making. The analysis of these discussions resulted in a revised framework consisting of nine conceptual knowledge components, three sociocultural components, and four epistemic components. The framework can be used in curricular decisions; its open character allows for including new technologies and applications and facilitates comparisons of different cases.

  13. Reaching a Consensus on the Definition of Genetic Literacy that Is Required from a Twenty-First-Century Citizen

    Science.gov (United States)

    Boerwinkel, Dirk Jan; Yarden, Anat; Waarlo, Arend Jan

    2017-11-01

    To determine what knowledge of genetics is needed for decision-making on genetic-related issues, a consensus-reaching approach was used. An international group of 57 experts, involved in teaching, studying, or developing genetic education and communication or working with genetic applications in medicine, agriculture, or forensics, answered the questions: "What knowledge of genetics is relevant to those individuals not professionally involved in science?" and "Why is this knowledge relevant?" The answers were classified in different knowledge components following the PISA 2015 science framework. During a workshop with the participants, the results were discussed and applied to seven cases in which genetic knowledge is relevant for decision-making. The analysis of these discussions resulted in a revised framework consisting of nine conceptual knowledge components, three sociocultural components, and four epistemic components. The framework can be used in curricular decisions; its open character allows for including new technologies and applications and facilitates comparisons of different cases.

  14. A Desmoplastic Small Round Cell Tumor in a Twenty-Eight Year-old Adult Male Presenting with Urological Symptoms

    Directory of Open Access Journals (Sweden)

    Amr Idris

    2015-01-01

    Full Text Available A desmoplastic small round cell tumor is a malignant tumor of the abdominal and pelvic cavities. This tumor involves serosal surfaces such as the peritoneum, pleura, and scrotum. In this case report a 28-year old male presented with a desmoplastic small round cell tumor located in the abdomen along with urological symptoms. When the diagnosis was completed, the patient’s tumor had metastasized to the liver and retroperitoneal lymph nodes. This case not only has exemplified that this tumor is rare and fatal but its prompt diagnosis is critical. However it is most likely that the diagnosis of this tumor is found when it has metastasized and this is unfortunately very late.

  15. Squamous cell carcinoma of the mastoid – a report of two cases ...

    African Journals Online (AJOL)

    Malignant tumours of the mastoid are rare, the majority being squamous cell carcinomas. We report two cases whose clinical presentation mimicked mastoid abscess with intracranial complications. The first case is a twenty year Nigerian lady who presented to the Emergency Room of the Otorhinolaryngology Department ...

  16. Localized Giant Cell Tumors of the Flexor Tendon Sheath of the Finger: An Analysis of Twenty Five Patients

    Directory of Open Access Journals (Sweden)

    Asli Tanrivermis Sayit

    2014-12-01

    Full Text Available Aim: The aims of this retrospective study were to evaluate localized giant cell tumors of the tendon sheath (GCTTS with Magnetic Resonance (MR imaging findings and to review the epidemiological features of the disease. We also evaluated the literature regarding GCTTS and performed an analysis of the available information. Material and Method: We retrospectively reviewed the MR images of 25 histologically proven cases of GCTTS of the finger during the period between 2012-2014. In addition, a retrospective analysis of the patients’ records was carried out, and age, gender, site and size of lesion, recurrence, and MRI findings were reviewed. Results: The patients were predominantly female (n = 16 and had a mean age of 51.9 ± 12.8 years. Nine patients were male with a mean age of 45.1 ± 13.4 years. The size of the tumors ranged from 6 mm to 30 mm, with a mean size of 15.3±6.8 mm. Tumors were present on the right hand in 15 patients and on the left hand in 10 patients. Among women, 11 tumors were located on the right hand and 5 were found on the left. In men, 4 of the tumors were located on the right hand and 5 were on the left. The most frequent digit on which tumors were found was the index finger, accounting for 40% of cases (n=10. The most frequent location was the index finger for both women (n=6 and men (n=4. All of the lesions were described as well-circumscribed, encapsulated, lobulated, or multilobulated solitary masses with MR imaging. Signal intensity on T1 weighted images (WI was equal to that of skeletal muscle in 23 cases. In two cases, signal intensity was slightly higher. On T2WIs, the signal intensities tended to be between those of skeletal muscle and fat in all of the cases. All of the lesions showed mild to moderate contrast enhancement when compared with precontrast images. There was no statistically significant differences between male and female patients in terms of age, tumor side, involved digit, and highest tumor size

  17. Validity aspects in Chernobyl at twenty years of the accident; Aspectos vigentes en Chernobyl a veinte anos del accidente

    Energy Technology Data Exchange (ETDEWEB)

    Arredondo, C. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)]. e-mail: cas@nuclear.inin.mx

    2006-07-01

    inventory of rare gases of the core. The consequences of the accident have been studied during the twenty lapsed years since it happened. In this work the more recent discoveries on the effects in the health, the environment and economic that have been reported, as well as the current advances regarding the solution of the problems with the sarcophagus are commented. Other aspects little mentioned that consequences of the accident can be considered are discussed also, like they are the increment in the nuclear safety in the reactors in operation in the entire world and the termination of the cold war with the consequent dismantlement of a great one numbers of nuclear weapons. Finally it is remembered that the lessons learned in Chernobyl should never be forgotten. (Author)

  18. Case-control study of mesothelioma in South Africa.

    Science.gov (United States)

    Rees, D; Myers, J E; Goodman, K; Fourie, E; Blignaut, C; Chapman, R; Bachmann, M O

    1999-03-01

    South Africa has, uniquely, mined, transported, and used crocidolite, amosite, and chrysotile. A multicenter case-control study was done in South Africa to examine the details of asbestos exposure in cases and controls, and to calculate relative risks for level of certainty of asbestos exposure, nature of exposure (e.g., environmental, occupational) and fiber type. Cases and controls (one cancer and one medical per case) were collected by six study centers from referral hospitals, and exposure information was collected by interviewing cases and controls in life. One hundred and twenty-three cases were accepted into the study. None had purely chrysotile exposure. Twenty-three cases had mined Cape crocidolite; three had mined amosite; and three Transvaal crocidolite plus amosite. A minimum of 22 of the cases had exclusively environmental exposure, 20 were from the NW Cape crocidolite mining area. The relative risks associated with environmental exposure in the NW Cape (crocidolite) were larger than for environmental exposure in the NE Transvaal (amosite and crocidolite): 21.9 vs. 7.1 and 50.9 vs. 12.0 for the cancer control and medical control datasets, respectively. The results confirm the importance of environmental exposure in the Cape crocidolite mining area, the relative paucity of cases linked to amosite, the rarity of chrysotile cases and are consistent with a fiber gradient in mesotheliomagenic potential for South African asbestos with crocidolite > amosite > chrysotile.

  19. Profile of research published in the annals of the Brazilian Pulmonology and Phthisiology Conferences held over the last twenty years.

    Science.gov (United States)

    Fabro, Alexandre Todorovic; Yoo, Hugo Hyung Bok; Queluz, Thais Helena Abrahão Thomaz

    2006-01-01

    To increase the knowledge base regarding pulmonology research in Brazil. A retrospective, observational study of the abstracts published in the Annals of the Brazilian Pulmonology and Phthisiology Conferences held from 1986 to 2004, quantifying the institutions of origin by geographic distribution and type, as well as categorizing the abstracts by study design and topic. A total of 6467 abstracts were published. The institutions of origin were located, variously, in the Southeast (3870 abstracts), South (1309), Northeast (783), Central-West (267) and North (84). There were 94 abstracts originating from foreign institutions, especially from institutions in Portugal (56.3%) and the United States (13.8%). Most of the studies (5825) were conducted in public Brazilian institutions. There were 4234 clinical studies, 1994 case reports and 239 original research articles. A marked, progressive increase was observed in the number of clinical studies and case reports during the period evaluated. Overall, the most common themes were tuberculosis and other infections diseases (25.2%), following by oncology (11.6%), interstitial lung diseases (8.8%) and thoracic surgery (8.5%). Nevertheless, the number of abstracts on each topic varied widely from year to year. Public Brazilian institutions are the principal sources of pulmonology research in Brazil. Such research activity is concentrated in the southeastern part of the country. Case reports account for one-third of this activity. Although there was great variability in the subjects addressed, diseases that are highly prevalent in Brazil, such as tuberculosis and other infections diseases, were the most common topics.

  20. Case Report

    African Journals Online (AJOL)

    Dr Adaji

    Vol 7 No 1-2,2005: 220 - 221. Case Report. A huge polypoid uterine myoma causing severe primary postpartum haemorrhage. A report of one case. S E Adaji , S O Shittu, and B R Ageda. Department of Obstetrics and Gynecology, Ahmadu Bello University Teaching Hospital, PMB 1026 Zaria,. Nigeria. Requests for reprints ...

  1. Case report

    African Journals Online (AJOL)

    abp

    2015-06-03

    Jun 3, 2015 ... Abstract. Portal vein thrombosis is a relatively rare but well-known complication of cirrhosis that has a prevalence of between 1% and 5.7%. On the contrary, in case of hepatocellular carcinoma (HCC), it is a much more frequent complication. In this paper, we presented three cases that had liver cirrhosis ...

  2. Case series

    African Journals Online (AJOL)

    abp

    2014-01-20

    Jan 20, 2014 ... Retrospective study performed at the Neurology department Mohammed VI universitary hospital in Marrakesh interesting 128 patients. The diagnosis ... rehabilitation after the acute phase of the stroke. Our study points .... cases, dominated by valvular rhumatic diseases, the existence of 14. (11%) cases of ...

  3. Case work

    DEFF Research Database (Denmark)

    Shaw, Ian Frank

    2016-01-01

    Answers to the question just what is the ?case? partly defined the fields of sociology and social work in early 20th century Chicago. Drawing on the archives of the University of Chicago, I describe and appraise the way the ?case? figured in social work at Chicago and elsewhere. I ask...

  4. . Case Report

    African Journals Online (AJOL)

    Case Report. PYOMETRA IN A GREAT DANE: A CASE REPORT. EZE, C.A. and NNAJI*, T.O.. Department of Veterinary Surgery, University ofNigeria, Nsukka, Nigeria. *Correspondence: E-mail: Tel: +2348056224988. INTRODUCTION. Pyometra is a condition mainly of middle-aged female dogs that have not been spayed.

  5. CASE REPORT

    African Journals Online (AJOL)

    DR ABDUL

    CASE REPORT. Intussusception in pregnancy: report of a case. M. A. Abdul, * L. M. D. Yusufu and D. Haggai. Departments of Obstetrics and Gynaecology and Surgery, Ahmadu Bello University Teaching Hospital, Zaria. Reprint requests to: Dr. M.A. Abdul, Department of Obstetrics and Gynaecology, Ahmadu Bello ...

  6. Case report

    African Journals Online (AJOL)

    abp

    2015-01-29

    Jan 29, 2015 ... Adenoid cystic carcinoma of cervix: two cases report and review of the literature ... ACC of the cervix. Billroth in 1859 originally defined this lesion as. ''tumor composed of small basal cells with slight eosinophilic cytoplasm, hyperchromatic nuclei in ..... case report with implication for chemotherapy treatment.

  7. Case series

    African Journals Online (AJOL)

    abp

    25 mars 2016 ... Half of the patients had traditional wedding. Sexual intercourse was consensual in 74% of the cases. Vaginal bleeding ... Therapeutic management consisted of a surgical suture in 97% of the cases, associated with blood transfusion in two patients and sexual abstinence of all patients for at least two weeks.

  8. Case report

    African Journals Online (AJOL)

    abp

    2014-05-30

    May 30, 2014 ... extension to pleura, as found in the index case, is associated with effusion. Calcification and lymphadenopathy are rarely seen in these tumors. Distant metastasis spreads to lungs, bones, bone marrow, liver and brain [3]. In our literature review, most cases of Askin's tumor were presented as a mass in the ...

  9. Case series

    African Journals Online (AJOL)

    abp

    2017-05-16

    May 16, 2017 ... to provide an updated overview on clinicopathological features, treatment and outcome of HCC. ... Local recurrence of the tumour occurred in three cases and two patients had distant metastases postoperatively. The other patients are .... three cases of clear cell HCC so as to confirm diagnosis and to rule.

  10. Case report

    African Journals Online (AJOL)

    abp

    We report a case of mucoid degeneration of the anterior cruciate ligament (ACL). Mucoid degeneration of the ACL is a very rare cause of knee pain. There have been only some reported cases of mucoid degeneration of the ACL in the English literature. We reviewed previous reports and summarized clinical features and ...

  11. Pyott case

    African Journals Online (AJOL)

    kirstam

    iiSouthern African Business Review Special Edition Tax Stories 2015. Pyott case: A lasting deposit for our tax heritage. A.C. Engelbrecht, G.K. Goldswain & A. Heyns. 3ABSTRACT. 5Pyott Ltd v CIR is generally regarded as the seminal case in South Africa on the tax treatment of deposits received on containers that may.

  12. Case Report

    African Journals Online (AJOL)

    Hydatid disease may occur in any organ of the human body, but an isolated retrovesical hydatid. (RVH) cyst is rare. We report two cases of isolated RVH cyst - one mimicking an ovarian cyst, the other presenting as acute urinary retention - and a third case of RVH cyst associated with bladder and rectal fistula and a hepatic ...

  13. Case report

    African Journals Online (AJOL)

    abp

    9 juil. 2015 ... Albert H. Diffuse idiopathic hypertrophy of the mammary glands of the female: a report of a new case and a consideration of the etiology and pathology based on data of recorded cases. JAMA.1910; 55: 1339-43.PubMed | Google · Scholar. 8. Lafrenière R, Temple W, Ketchman A. Gestationnal macromastia.

  14. Case report

    African Journals Online (AJOL)

    abp

    2017-05-08

    May 8, 2017 ... Abstract. Although abdominal pain is a common presentation in emergency departments, rectus sheath hematoma (RSH) is among the rarest diagnosis. Here we present 2 cases of RSH likely caused by coughing due to upper respiratory tract infection. The two described cases were diagnosed by bedside ...

  15. Case report

    African Journals Online (AJOL)

    abp

    2014-02-07

    Feb 7, 2014 ... developed visceral leishmaniasis and MAS one year after the initiation of the treatment [5]. The MAS was imputed in this case to the visceral leishmaniasis, and adalimumab was considered as a predisposing cause of this infection. Only two previous cases of MAS in patients with AOSD during adalimumab ...

  16. Case report

    African Journals Online (AJOL)

    abp

    21 mai 2015 ... Anastasopoulos N, Totlis T. Bilateral rectus femoris intramuscular haematoma following simultaneous quadriceps strain in an athlete: a case report. J Med Case Rep. 2010;4:56. PubMed | Google Scholar. 7. Liow RY, Tavares S. Bilateral rupture of the quadriceps tendon associated with anabolic steroids.

  17. Case Report

    African Journals Online (AJOL)

    Hamid

    www.ljm.org.ly. Case Report. Fiber-reinforced Composite for Chairside Replacement of Anterior. Teeth: A Case Report. Garoushi S1,2, Vallittu PK1, Lassila LVJ1. 1Department of Prosthetic Dentistry & Biomaterials Science, Institute of Dentistry,. University of Turku, Turku, Finland. 2Benghazi Dental Centre, Benghazi, Libya.

  18. Encouraging Cases

    DEFF Research Database (Denmark)

    Koss Rasmussen, Rasmus

    recognizable to the mainstream in progressive ways. This paper seeks to remedy this lacunae by linking the concept of Critical Performativity (Spicer, Alvesson & Kärreman, 2009) to case study research and shows how case studies informed by Critical Realism (Easton, 2010a) can be generalized to “what could be...

  19. Case series

    African Journals Online (AJOL)

    ebutamanya

    2015-08-11

    Aug 11, 2015 ... rehabilitation was performed in each case after initial resuscitation. Duration from caustic ingestion to the time of surgery was 9 months for the Case A and more ... Post-operative care: patients were admitted to the ICU for continuous monitoring following extubation in theatre. Hypotension was avoided in the.

  20. Quantitative MRI analysis of the brain after twenty-two years of neuromyelitis optica indicates focal tissue damage

    DEFF Research Database (Denmark)

    Aradi, Mihaly; Koszegi, Edit; Orsi, Gergely

    2013-01-01

    BACKGROUND: The long-term effect of neuromyelitis optica (NMO) on the brain is not well established. METHODS: After 22 years of NMO, a patient's brain was examined by quantitative T1- and T2-weighted mono- and biexponential diffusion and proton spectroscopy. It was compared to 3 cases with short......, and they were also not quantitatively different from the controls. CONCLUSION: After NMO of 22-year duration, metabolic changes, altered diffusivity and magnetic resonance relaxation features of patchy brain areas may suggest tissue damage in NAWM that persist for at least 6 months....

  1. [Clinical analysis of 28 cases of bronchiolitis obliterans].

    Science.gov (United States)

    Wu, Xiao-Ying; Luo, Zheng-Xiu; Fu, Zhou; Liu, En-Mei; Luo, Jian; He, Ling

    2013-10-01

    To study the clinical features of bronchiolitis obliterans (BO) in children. The clinical data of 28 children with BO between July 2007 and April 2012 was retrospectively reviewed. All patients presented with persistent or repeated cough and wheezing. Twenty-three cases were post-infectious bronchiolitis obliterans (PIBO), among whom the etiology were adenovirus (12 cases), measles (2 cases), influenza virus A (2 cases), mycoplasma pneumoniae (1 case), mycoplasma pneumoniae coinfection with adenovirus (1 case), respiratory syncytial virus coinfection with Parainfluenza type 3 virus (1 case) and pulmonary tuberculosis (1 case). The etiology of 3 cases was not associated with infection. The etiology was unknown in 2 cases. Pulmonary HRCT revealed that decreased density in 25 cases, mosaic perfusion in 21 cases, bronchial wall thickening in 15 cases, bronchiectasis in 12 cases and air retention in 6 cases. Lung function test was performed on 21 cases and demonstrated that obstructive ventilation disorder in all 21 cases. Bronchodilation test was performed on 18 cases and 17 cases showed a negative result. All 28 cases received corticosteroid treatment, and 24 cases were orally administered with low doses of azithromycin. One case died during hospitalization. Eighteen cases were followed up for 4 months to 4 years and seven months. Clinical manifestations were improved in 12 cases and one case died. Low respiratory infection is the most common cause of pediatric BO and adenovirus is a major pathogen. Persistent wheezing and cough were main clinical manifestations. Pulmonary HRCT imaging is important for diagnosis and follow-up of BO. Lung function test can typically show obstructive ventilation disorder. Corticosteroid and methotrexate may be effective for treatment of BO. Prognosis of this disease is unsatisfactory. Early diagnosis and treatment, and avoidance of repeated respiratory tract infection may be helpful to improve the prognosis.

  2. Case - Case-Law - Law

    DEFF Research Database (Denmark)

    Sadl, Urska

    2013-01-01

    Reasoning of the Court of Justice of the European Union – Constr uction of arguments in the case-law of the Court – Citation technique – The use of formulas to transform case-law into ‘law’ – ‘Formulaic style’ – European citizenship as a fundamental status – Ruiz Zambrano – Reasoning from consequ...

  3. Training medical students in health promotion: twenty years of experience at the Faculty of Medicine of the University of Geneva.

    Science.gov (United States)

    Mattig, Thomas; Chastonay, Philippe; Kabengele, Emmanuel; Bernheim, Laurent

    2017-01-01

    Background: In most cases, the work of medical doctors, be they general practitioners or specialists, involves some dimension of health promotion (HP). There is thus ample justification for increasing the awareness of medical students vis-à-vis HP and its relevance for their future practice. Methods: In the context of a major curriculum reform (problem-based learning [PBL]) at the Faculty of Medicine of the University of Geneva in the mid-1990s, several steps were taken to strengthen HP throughout the curriculum and include HP in its key domains as defined by the Ottawa Charter (OC). Results: First, the political dimension of HP was developed in a series of first- and fifth-year lectures and third-year workshops; second, community action was strengthened through a third-year one-month community immersion program; third, the development of personal skills was integrated into second- and third-year PBL cases and into fourth-and fifth-year learning activities in clinical settings as well as second- and third-year HP electives; in terms of reorienting health services, the chosen approach included the development of a HP-specific track in the context of a Certificate of Advanced Studies (CAS) in Community Health and a Master of Advanced Studies(MAS) in Public Health. Furthermore, a supportive intra-university environment was created through a collaborative convention with Health Promotion Switzerland, which is in charge of coordinating HP in Switzerland. Conclusion: In our view, HP teaching for medical students seems all the more relevant given that future medical doctors will have to take care of an increasing number of patients likely to develop chronic non-communicable diseases.

  4. Training medical students in health promotion: twenty years of experience at the Faculty of Medicine of the University of Geneva

    Directory of Open Access Journals (Sweden)

    Thomas Mattig

    2017-09-01

    Full Text Available Background: In most cases, the work of medical doctors, be they general practitioners or specialists, involves some dimension of health promotion (HP. There is thus ample justification for increasing the awareness of medical students vis-à-vis HP and its relevance for their future practice.Methods: In the context of a major curriculum reform (problem-based learning [PBL] at the Faculty of Medicine of the University of Geneva in the mid-1990s, several steps were taken to strengthen HP throughout the curriculum and include HP in its key domains as defined by the Ottawa Charter (OC.Results: First, the political dimension of HP was developed in a series of first- and fifth-year lectures and third-year workshops; second, community action was strengthened through a third year one-month community immersion program; third, the development of personal skills was integrated into second- and third-year PBL cases and into fourth-and fifth-year learning activities in clinical settings as well as second- and third-year HP electives; in terms of reorienting health services, the chosen approach included the development of a HP-specific track in the context of a Certificate of Advanced Studies (CAS in Community Health and a Master of Advanced Studies(MAS in Public Health. Furthermore, a supportive intra-university environment was created through a collaborative convention with Health Promotion Switzerland, which is in charge of coordinating HP in Switzerland.Conclusion: In our view, HP teaching for medical students seems all the more relevant given that future medical doctors will have to take care of an increasing number of patients likely to develop chronic non-communicable diseases.

  5. "The First Twenty Years," by Bernard J. Siegel. Annual Review of Anthropology, 22 (1993, pp. 1-34, Annual Reviews, Inc, Palo Alto

    Directory of Open Access Journals (Sweden)

    James A. Delle

    1995-05-01

    Full Text Available After twenty years as editor of the Annual Review ofAnthropology (ARA, Professor Siegel took on a daunting task with this article. In his words, he set out to "ponder the developments in the several subfields of anthropol­ogy over this period of time, as reflected in the topics selected for review in this enterprise" (p. 8. To this end Siegel, a cultural anthropologist, mined the collective knowledge contained within twenty years of the ARA. In his presentation, he considers the intellectual developments within each of the five subdisciplines separately (he includes applied anthropology, concluding with some brief remarks on the importance of maintaining a four or five field approach to anthropology. For our purposes here, I will limit my comments to his section on archaeology.

  6. Changing ideas in forestry: A comparison of concepts in Swedish and American forestry journals during the early twentieth and twenty-first centuries.

    Science.gov (United States)

    Mårald, Erland; Langston, Nancy; Sténs, Anna; Moen, Jon

    2016-02-01

    By combining digital humanities text-mining tools and a qualitative approach, we examine changing concepts in forestry journals in Sweden and the United States (US) in the early twentieth and early twenty-first centuries. Our first hypothesis is that foresters at the beginning of the twentieth century were more concerned with production and less concerned with ecology than foresters at the beginning of the twenty-first century. Our second hypothesis is that US foresters in the early twentieth century were less concerned with local site conditions than Swedish foresters. We find that early foresters in both countries had broader-and often ecologically focused-concerns than hypothesized. Ecological concerns in the forestry literature have increased, but in the Nordic countries, production concerns have increased as well. In both regions and both time periods, timber management is closely connected to concerns about governance and state power, but the forms that governance takes have changed.

  7. Adverse events associated with yoga: a systematic review of published case reports and case series.

    Science.gov (United States)

    Cramer, Holger; Krucoff, Carol; Dobos, Gustav

    2013-01-01

    While yoga is gaining increased popularity in North America and Europe, its safety has been questioned in the lay press. The aim of this systematic review was to assess published case reports and case series on adverse events associated with yoga. Medline/Pubmed, Scopus, CAMBase, IndMed and the Cases Database were screened through February 2013; and 35 case reports and 2 case series reporting a total of 76 cases were included. Ten cases had medical preconditions, mainly glaucoma and osteopenia. Pranayama, hatha yoga, and Bikram yoga were the most common yoga practices; headstand, shoulder stand, lotus position, and forceful breathing were the most common yoga postures and breathing techniques cited. Twenty-seven adverse events (35.5%) affected the musculoskeletal system; 14 (18.4%) the nervous system; and 9 (11.8%) the eyes. Fifteen cases (19.7%) reached full recovery; 9 cases (11.3%) partial recovery; 1 case (1.3%) no recovery; and 1 case (1.3%) died. As any other physical or mental practice, yoga should be practiced carefully under the guidance of a qualified instructor. Beginners should avoid extreme practices such as headstand, lotus position and forceful breathing. Individuals with medical preconditions should work with their physician and yoga teacher to appropriately adapt postures; patients with glaucoma should avoid inversions and patients with compromised bone should avoid forceful yoga practices.

  8. Adverse events associated with yoga: a systematic review of published case reports and case series.

    Directory of Open Access Journals (Sweden)

    Holger Cramer

    Full Text Available While yoga is gaining increased popularity in North America and Europe, its safety has been questioned in the lay press. The aim of this systematic review was to assess published case reports and case series on adverse events associated with yoga. Medline/Pubmed, Scopus, CAMBase, IndMed and the Cases Database were screened through February 2013; and 35 case reports and 2 case series reporting a total of 76 cases were included. Ten cases had medical preconditions, mainly glaucoma and osteopenia. Pranayama, hatha yoga, and Bikram yoga were the most common yoga practices; headstand, shoulder stand, lotus position, and forceful breathing were the most common yoga postures and breathing techniques cited. Twenty-seven adverse events (35.5% affected the musculoskeletal system; 14 (18.4% the nervous system; and 9 (11.8% the eyes. Fifteen cases (19.7% reached full recovery; 9 cases (11.3% partial recovery; 1 case (1.3% no recovery; and 1 case (1.3% died. As any other physical or mental practice, yoga should be practiced carefully under the guidance of a qualified instructor. Beginners should avoid extreme practices such as headstand, lotus position and forceful breathing. Individuals with medical preconditions should work with their physician and yoga teacher to appropriately adapt postures; patients with glaucoma should avoid inversions and patients with compromised bone should avoid forceful yoga practices.

  9. Case report

    African Journals Online (AJOL)

    sdsuser42

    2012-06-10

    .com/content/article/12/27/full/ ... patients. Pulmonary carcinomas are much rare than other carcinoma in non-smoking acromegalic patients. We report a case of epidermoid carcinoma in ... surgery and radiotherapy. She was ...

  10. CASE REPORT

    African Journals Online (AJOL)

    MICROBXOLSQ): 39-43. ENDOMETRIAL TUBERCULOSIS IN INFERTILITY : REPORT OF 2 CASES AND A ... sterility. Despite the decline infroqnenq/ofgenital tuberenlesisin7mdIstrialiluhvotld ooipledvrillvnllespread' aseofantlbiotacs' ' ' worldwide,' itstillremam' apofiblecanseof ... primary infertility secondary to tuberculous.

  11. Case report

    African Journals Online (AJOL)

    abp

    2013-01-09

    MRI), Cholecystectomy. Received: 14/12/2011 ... observation a new case of primary hydatid cyst of the gallbladder diagnosed by Magnetic Resonance Imaging (MRI). Pan African Medical ... work is properly cited. Pan African ...

  12. Laser corneal refractive surgery in the twenty-first century: a review of the impact of refractive surgery on high-order aberrations (and vice versa)

    Science.gov (United States)

    Arba-Mosquera, Samuel; Arbelaez, Maria C.; de Ortueta, Diego

    2010-07-01

    Here we review the situation of laser corneal refractive surgery in the twenty-first century. We pay special attention to the change in aberrations, covering the compensation of the loss of ablation efficiency at non-normal incidence, the effects of cyclotorsional errors, aspheric, wavefront optimized and aberration neutral concepts, and centration of refractive profiles. A review of the clinical outcomes is provided including myopic, hyperopic, and astigmatic, as well as wavefront customized or presbyopic outcomes.

  13. Twenty-fifth Semiannual Report of the Commission to the Congress, January 1959. Atomic Industrial Process and Second World Conference, July - December 1958

    Energy Technology Data Exchange (ETDEWEB)

    McCone, John A.

    1959-01-31

    The document represents the twenty-fifth semiannual Atomic Energy Commission (AEC) report to Congress. The report sums up the major activities and developments in the national atomic energy program in Part Three, covering the period July - December 1958. A special Part One of this semiannual report is titled ''Industrial Atomic Progress During 1958", and a Part Two entitled "Second World Conference on Peaceful Uses of Atomic Energy".

  14. Change and Continuity in Librarianship: Approaching the Twenty-First Century. Proceedings of the 40th Military Librarians Workshop, 20-22 November 1996, Annapolis, Maryland,

    Science.gov (United States)

    1996-11-01

    Novembecr 1996 Arinarolis, Maryland1 rDIO QUALMTY DZEOTN I VIBYKUTON UrtAIK=yg A Change and Continuity in Librarianship : Approaching the Twenty-first...speakers Walt Crawford (Keynote), speaking on "Millennial Librarianship ;" Dr. Keith Swigger, Dean of the Graduate School of Library and Information...1 --Richard Hume Werking Millennial Librarianship : Maintaining the Mix and Avoiding the Hype .................. 2 --Walt Crawford

  15. Application of the Intervention Mapping Framework to Develop an Integrated Twenty-first Century Core Curriculum—Part Three: Curriculum Implementation and Evaluation

    OpenAIRE

    Corvin, Jaime A.; Rita DeBate; Kate Wolfe-Quintero; Petersen, Donna J.

    2017-01-01

    Public health professionals have been challenged to radically reform public health training to meet evolving demands of twenty-first century public health. Such a transformation requires a systems thinking approach with an interdisciplinary focus on problem solving, leadership, management and teamwork, technology and information, budgeting and finance, and communication. This article presents processes for implementing and evaluating a revised public health curriculum and outlines lessons lea...

  16. Ophthalmology case

    OpenAIRE

    Fábio Barroso; Ana Lachado; Luísa Carreira; Gilberta Santos; José Pombeiro; Vasco Miranda

    2017-01-01

    Introduction: Limbal dermoids are benign congenital tumours that contain choristomatous elements. These lesions are present at birth but may not be easily identified until later in life. Case report: We report a case of a one-day-old newborn, female, with no relevant gestational or neonatal history, referred to our pediatric ophthalmologic unit because of a whitish round mass in the inferotemporal limbus of the left eye. Clinical examination confirmed the diagnosis of limbal dermoid cyst, ...

  17. DERMATOLOGY CASE

    Directory of Open Access Journals (Sweden)

    Inês Falcão

    2017-04-01

    Full Text Available Nevus spilus is a melanocytic lesion which can be congenital or develop early in life. This lesion varies considerably in size and can occur anywhere on the body. Although nevus spilus is benign, it has malignant potential and melanoma develops in rare cases. Prevention and early detection are mandatory. We describe the case of a nine-year-old boy with a nevus spilus.

  18. Case management: a case study.

    Science.gov (United States)

    Dring, R; Hiott, B; Elliott, K

    1994-06-01

    Prior to institution of case management Mr. G would have remained on the neuroscience acute care unit until nursing home placement could be arranged, a process which often took a year because of the severe shortage of Medicaid beds in South Carolina. Because case managers collaborated to identify and resolve the problem, the outcome for those such as Mr. G has changed. Case management facilitates movement of patients with complex problems from acute care to successful community reentry in a cost-effective manner.

  19. Dissecting malpractice in pancreaticoduodenectomy cases.

    Science.gov (United States)

    Anandalwar, Seema P; Scholer, Anthony J; Ninan, Gigio; Oliver, Joseph B; Christian, Derick; Eloy, Jean Anderson; Chokshi, Ravi J

    2017-05-15

    Medical malpractice is a growing concern for physicians in all fields. Surgical fields have some of the highest malpractice premiums and litigation rates. Pancreaticoduodenectomy (PD) has become a popular procedure; however, it is still associated with significant morbidity and mortality. This study is the first to analyze factors involved in litigation regarding PD cases. The Westlaw database was searched for jury verdicts and settlements using the terms "medical malpractice" and "pancreaticoduodenectomy". Twenty-nine cases from 1991 to 2012 were initially collected. Seven entries not involving PD and three duplicate cases were excluded. Nineteen cases were included for analysis. Of the 19 cases included in the analysis, three (15.8%) reached a settlement, three (15.8%) were ruled in favor of the plaintiff, and 13 (68.4%) were ruled in favor of the physician. The average settlement award was $398,333 (range, $195,000-500,000), and the average plaintiff award was $4,288,869 (range, $1,066,608-10,300,000). The most common factors raised in litigation included PD being allegedly unnecessary (47.4%), followed by postoperative negligence and misdiagnosis (36.8% each). The most common factors present in litigation included the allegation that PD was unnecessarily performed. The cases that are awarded large monetary sums are those that involve continued medical care. Ways to improve patient safety and limit litigation include increasing transparency and communication with a thorough discussion between surgeon and patient of the most common topics of litigation discussed. Published by Elsevier Inc.

  20. [Twenty-five years' experience in epidemiology and prophylaxis of epidemics at the Centre for Salmonella of Hamburg (author's transl)].

    Science.gov (United States)

    Winkle, S; Rohde, R

    1979-04-01

    Salmonella-epidemiology has changed fundamentally since underdeveloped countries have entered international trade and export food-supplies which, due to less stringent controls, are already contaminated either in the countries of origin or in transit. This is shown by numerous case histories of food-poisoning. Multifarious causes of infection from imported food-stuffs are exposed and also the epidemiological consequences from latently infected fat-stock and poultry. Prophylactic measures and advice on preventive treatment are given. The progressive automation in many factories and plants, with aspirations to the highes-degree of efficiency, frequently hides potential sources of infection with a shining facade of chrome and plastic. In the planning and servicing of technical installations, which later may well prove to be a source of infection, sanitary experts are rarely consulted, or if so too late. This paper also emphasises the considerable influence of mass-tourism with the consequent introduction of exotic Salmonella serotypes, and also the potential danger of faeca contamination on motorway rest-stops.