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Sample records for chips full-image micro-piv

  1. Acoustic resonances in microfluidic chips: full-image micro-PIV experiments and numerical simulations.

    Science.gov (United States)

    Hagsäter, S M; Jensen, T Glasdam; Bruus, H; Kutter, J P

    2007-10-01

    We show that full-image micro-PIV analysis in combination with images of transient particle motion is a powerful tool for experimental studies of acoustic radiation forces and acoustic streaming in microfluidic chambers under piezo-actuation in the MHz range. The measured steady-state motion of both large 5 microm and small 1 microm particles can be understood in terms of the acoustic eigenmodes or standing ultra-sound waves in the given experimental microsystems. This interpretation is supported by numerical solutions of the corresponding acoustic wave equation.

  2. Acoustic resonances in microfluidic chips: full-image micro-PIV experiments and numerical simulations

    DEFF Research Database (Denmark)

    Hagsäter, Melker; Jensen, Thomas Glasdam; Bruus, Henrik

    2007-01-01

    to different aqueous phases in two-phase systems. This separation process may be enhanced or extended by applying an electric field perpendicular to the phase boundary. In this context, microsystems offer new possibilities, as interfacial forces usually dominate over volume forces, thus allowing a superior......This work reports on protein transport phenomena discovered in partitioning experiments with a novel setup for continuous-flow two-phase electrophoresis consisting of a microchannel in which a phase boundary is formed in flow direction. Proteins can be partitioned exploiting their affinity...... control of the formation and arrangement of liquid/liquid phase boundaries. The two immiscible phases which are injected separately into the microchannel are taken from a polyethylene glycol (PEG)–dextran system. The side walls of the channel are partially made of gel material which serves as an ion...

  3. An automated full-chip micro-piv setup for measuring microchannel acoustophoresis:

    DEFF Research Database (Denmark)

    Barnkob, Rune; Augustsson, P.; Laurell, T.

    2011-01-01

    We present a novel μm-resolution particle-image velocimetry setup capable of automated full-chip measurements of microchannel acoustophoresis. Our system allows for fast collection of a sufficient amount of data enabling reliable determination of the influence from the forces from acoustic radiat...

  4. Investigations on LED illumination for micro-PIV including a novel front-lit configuration

    DEFF Research Database (Denmark)

    Hagsäter, Melker; Bruus, Henrik; Kutter, Jörg Peter

    2008-01-01

    In this study, we provide a general investigation on micro-PIV with LED illumination. A number of improvements over previous LED-based systems are suggested, in particular, we present a novel front-lit configuration. As a demonstration of its versatility we have used this front-lit configuration...... to perform micro-PIV measurements around a 50 mu m squared pillar in a micro-channel with rectangular cross section, in both fluorescent mode and scattered mode. A comparison between the two modes is supplied, showing very good agreement between the respective velocity field results....

  5. Three-dimensional measurement and visualization of internal flow of a moving droplet using confocal micro-PIV.

    Science.gov (United States)

    Kinoshita, Haruyuki; Kaneda, Shohei; Fujii, Teruo; Oshima, Marie

    2007-03-01

    This paper presents a micro-flow diagnostic technique, 'high-speed confocal micro-particle image velocimetry (PIV)', and its application to the internal flow measurement of a droplet passing through a microchannel. A confocal micro-PIV system has been successfully constructed wherein a high-speed confocal scanner is combined with the conventional micro-PIV technique. The confocal micro-PIV system enables us to obtain a sequence of sharp and high-contrast cross-sectional particle images at 2000 frames s(-1). This study investigates the confocal depth, which is a significant parameter to determine the out-of-plane measurement resolution in confocal micro-PIV. Using the present confocal micro-PIV system, we can measure velocity distributions of micro-flows in a 228 microm x 171 microm region with a confocal depth of 1.88 microm. We also propose a three-dimensional velocity measurement method based on the confocal micro-PIV and the equation of continuity. This method enables us to measure three velocity components in a three-dimensional domain of micro flows. The confocal micro-PIV system is applied to the internal flow measurement of a droplet. We have measured three-dimensional distributions of three-component velocities of a droplet traveling in a 100 microm (width) x 58 microm (depth) channel. A volumetric velocity distribution inside a droplet is obtained by the confocal micro-PIV and the three-dimensional flow structure inside the droplet is investigated. The measurement results suggest that a three-dimensional and complex circulating flow is formed inside the droplet.

  6. Visualizing the transient electroosmotic flow and measuring the zeta potential of microchannels with a micro-PIV technique.

    Science.gov (United States)

    Yan, Deguang; Nguyen, Nam-Trung; Yang, Chun; Huang, Xiaoyang

    2006-01-14

    We have demonstrated a transient micro particle image velocimetry (micro-PIV) technique to measure the temporal development of electroosmotic flow in microchannels. Synchronization of different trigger signals for the laser, the CCD camera, and the high-voltage switch makes this measurement possible with a conventional micro-PIV setup. Using the transient micro-PIV technique, we have further proposed a method on the basis of inertial decoupling between the particle electrophoretic motion and the fluid electroosmotic flow to determine the electrophoretic component in the particle velocity and the zeta potential of the channel wall. It is shown that using the measured zeta potentials, the theoretical predictions agree well with the transient response of the electroosmotic velocities measured in this work.

  7. A Micro-PIV Study of the Pulsed Micro-Flows Driven by an Insulin Pump

    Science.gov (United States)

    Wang, Bing; Demuren, Ayodeji; Gyuricsko, Eric; Hu, Hui

    2009-11-01

    In recent years, there is a surge in the popularity of using insulin pump or continuous subcutaneous insulin infusion therapy, as opposed to multiple daily injections by insulin syringe or an insulin pen. Some case studies have suggested that insulin delivery failure may be caused by precipitation of insulin within the infusion set. Speculation also exists that the flow of insulin through an insulin infusion set may be reduced or inhibited by air bubbles entrained into the micro-sized tubing system since there are chances that air be introduced into the insulin reservoir during the filling process. In the present study, a microscopic Particle Image Velocimtry (micro-PIV) system was used to characterize the transient behavior of the pulsed micro-flows inside the micro-sized tubing system of an insulin infusion set with insulin pump operating in basal mode (i.e., pulsed insulin pumping). The effects of the air bubbles entrained into the micro-sized tubing system on the insulin delivery process were assessed based on the micro-PIV measurements.

  8. Micro-PIV Study of Supercritical CO2-Water Interactions in Porous Micromodels

    Science.gov (United States)

    Kazemifar, Farzan; Blois, Gianluca; Christensen, Kenneth T.

    2015-11-01

    Multiphase flow of immiscible fluids in porous media is encountered in numerous natural systems and engineering applications such as enhanced oil recovery (EOR), and CO2 sequestration among others. Geological sequestration of CO2 in saline aquifers has emerged as a viable option for reducing CO2 emissions, and thus it has been the subject of numerous studies in recent years. A key objective is improving the accuracy of numerical models used for field-scale simulations by incorporation/better representation of the pore-scale flow physics. This necessitates experimental data for developing, testing and validating such models. We have studied drainage and imbibition processes in a homogeneous, two-dimensional porous micromodel with CO2 and water at reservoir-relevant conditions. Microscopic particle image velocimetry (micro-PIV) technique was applied to obtain spatially- and temporally-resolved velocity vector fields in the aqueous phase. The results provide new insight into the flow processes at the pore scale.

  9. Micro-PIV measurements of blood flow in extraembryonic blood vessels of chicken embryos.

    Science.gov (United States)

    Lee, Jung Yeop; Ji, Ho Seong; Lee, Sang Joon

    2007-10-01

    The hemodynamic characteristics of blood flow are important in the diagnosis of circulatory diseases, since such diseases are related to wall shear stress of cardiovascular vessels. In chicken embryos at early stages of development, it is possible to directly visualize blood flow inside blood vessels. We therefore employed a micro-PIV technique to assess blood flow in extraembryonic venous and arterial blood vessels of chicken embryos, using red blood cells (RBCs) as tracers and obtaining flow images of RBCs using a high-speed CMOS camera. The mean velocity field showed non-Newtonian flow characteristics. The blood flow in two venous vessels merged smoothly into the Y-shaped downstream vein without any flow separation or secondary flow. Vorticity was high in the inner regions, where the radius of curvature varied greatly. A periodic variation of temporally resolved velocity signals, due to beating of the heart, was observed in arterial blood vessels. The pulsating frequency was obtained by fast Fourier transform analysis using the measured velocity data. The measurement technique used here was useful in analyzing the hemodynamic characteristics of in vivo blood flow in chicken embryos.

  10. Investigating droplet internal flow in concentrated emulsion when flowing in microchannel using micro-PIV

    Science.gov (United States)

    Leong, Chia Min; Gai, Ya; Tang, Sindy K. Y.

    2016-11-01

    Droplet microfluidics has enabled a wide variety of high throughput applications through the use of monodisperse droplets. Previous fluid studies of droplet microfluidics have focused on single drops or emulsions at low volume fractions. The study of concentrated emulsions at high volume fractions is important for increasing the throughput, but the fluid dynamics of such emulsions in confined channels is not well understood. Here we describe two-dimensional, mid-height measurements of the flow inside individual drops within a concentrated emulsion using micro-PIV. The emulsion has 85% volume fraction and flows as a monolayer in a straight microfluidic channel. The effects of confinement and viscosity ratio on the internal flow patterns inside the drops were studied. The results show rotational structures inside the drops always exist, and are independent of viscosity ratio for the conditions tested. The structures depend on droplet mobility which in turn, depends on the confinement of the emulsion and the location of the drops in the channel. To our best knowledge, no work has probed the flow field inside droplets of concentrated emulsions at high volume fractions in confined channels. Current work is in progress to measure the three-dimensional flow field in such system.

  11. In vitro blood flow in a rectangular PDMS microchannel: experimental observations using a confocal micro-PIV system.

    Science.gov (United States)

    Lima, Rui; Wada, Shigeo; Tanaka, Shuji; Takeda, Motohiro; Ishikawa, Takuji; Tsubota, Ken-ichi; Imai, Yohsuke; Yamaguchi, Takami

    2008-04-01

    Progress in microfabricated technologies has attracted the attention of researchers in several areas, including microcirculation. Microfluidic devices are expected to provide powerful tools not only to better understand the biophysical behavior of blood flow in microvessels, but also for disease diagnosis. Such microfluidic devices for biomedical applications must be compatible with state-of-the-art flow measuring techniques, such as confocal microparticle image velocimetry (PIV). This confocal system has the ability to not only quantify flow patterns inside microchannels with high spatial and temporal resolution, but can also be used to obtain velocity measurements for several optically sectioned images along the depth of the microchannel. In this study, we investigated the ability to obtain velocity measurements using physiological saline (PS) and in vitro blood in a rectangular polydimethysiloxane (PDMS) microchannel (300 microm wide, 45 microm deep) using a confocal micro-PIV system. Applying this combination, measurements of trace particles seeded in the flow were performed for both fluids at a constant flow rate (Re = 0.02). Velocity profiles were acquired by successive measurements at different depth positions to obtain three-dimensional (3-D) information on the behavior of both fluid flows. Generally, the velocity profiles were found to be markedly blunt in the central region, mainly due to the low aspect ratio (h/w = 0.15) of the rectangular microchannel. Predictions using a theoretical model for the rectangular microchannel corresponded quite well with the experimental micro-PIV results for the PS fluid. However, for the in vitro blood with 20% hematocrit, small fluctuations were found in the velocity profiles. The present study clearly shows that confocal micro-PIV can be effectively integrated with a PDMS microchannel and used to obtain blood velocity profiles along the full depth of the microchannel because of its unique 3-D optical sectioning ability

  12. The measurements of water flow rates in the straight microchannel based on the scanning micro-PIV technique

    Science.gov (United States)

    Wang, H. L.; Han, W.; Xu, M.

    2011-12-01

    Measurement of the water flow rate in microchannel has been one of the hottest points in the applications of microfluidics, medical, biological, chemical analyses and so on. In this study, the scanning microscale particle image velocimetry (scanning micro-PIV) technique is used for the measurements of water flow rates in a straight microchannel of 200μm width and 60μm depth under the standard flow rates ranging from 2.481μL/min to 8.269μL/min. The main effort of this measurement technique is to obtain three-dimensional velocity distribution on the cross sections of microchannel by measuring velocities of the different fluid layers along the out-of-plane direction in the microchannel, so the water flow rates can be evaluated from the discrete surface integral of velocities on the cross section. At the same time, the three-dimensional velocity fields in the measured microchannel are simulated numerically using the FLUENT software in order to verify the velocity accuracy of measurement results. The results show that the experimental values of flow rates are well consistent to the standard flow rates input by the syringe pump and the compared results between numerical simulation and experiment are consistent fundamentally. This study indicates that the micro-flow rate evaluated from three-dimensional velocity by the scanning micro-PIV technique is a promising method for the micro-flow rate research.

  13. Acoustic radiation- and streaming-induced microparticle velocities determined by micro-PIV in an ultrasound symmetry plane

    CERN Document Server

    Barnkob, Rune; Laurell, Thomas; Bruus, Henrik

    2012-01-01

    We present micro-PIV measurements of suspended microparticles of diameters from 0.6 um to 10 um undergoing acoustophoresis in an ultrasound symmetry plane in a microchannel. The motion of the smallest particles are dominated by the Stokes drag from the induced acoustic streaming flow, while the motion of the largest particles are dominated by the acoustic radiation force. For all particle sizes we predict theoretically how much of the particle velocity is due to radiation and streaming, respectively. These predictions include corrections for particle-wall interactions and ultrasonic thermoviscous effects, and they match our measurements within the experimental uncertainty. Finally, we predict theoretically and confirm experimentally that the ratio between the acoustic radiation- and streaming-induced particle velocities is proportional to the square of the particle size, the actuation frequency and the acoustic contrast factor, while it is inversely proportional to the kinematic viscosity.

  14. In vitro confocal micro-PIV measurements of blood flow in a square microchannel: the effect of the haematocrit on instantaneous velocity profiles.

    Science.gov (United States)

    Lima, Rui; Wada, Shigeo; Takeda, Motohiro; Tsubota, Ken-ichi; Yamaguchi, Takami

    2007-01-01

    A confocal microparticle image velocimetry (micro-PIV) system was used to obtain detailed information on the velocity profiles for the flow of pure water (PW) and in vitro blood (haematocrit up to 17%) in a 100-microm-square microchannel. All the measurements were made in the middle plane of the microchannel at a constant flow rate and low Reynolds number (Re=0.025). The averaged ensemble velocity profiles were found to be markedly parabolic for all the working fluids studied. When comparing the instantaneous velocity profiles of the three fluids, our results indicated that the profile shape depended on the haematocrit. Our confocal micro-PIV measurements demonstrate that the root mean square (RMS) values increase with the haematocrit implying that it is important to consider the information provided by the instantaneous velocity fields, even at low Re. The present study also examines the potential effect of the RBCs on the accuracy of the instantaneous velocity measurements.

  15. The Measurements of Water Flow Rate in the T-shape Microchannels Based on the Scanning Micro-PIV Technique

    Science.gov (United States)

    Han, W.; Wang, H. L.; Xu, M.

    2011-09-01

    In this study, the scanning microfluidic particle image velocimetry (scanning micro-PIV) technique is used to measure the water flow rate in a T-shape microchannel with the inlet and outlet width being 300 μm and 200 μm, respectively. The standard flow rates controlled by the syringe pump are ranging from 3.508 to 11.693 μL/min. The quasi-three-dimensional velocities at the branch point of the T-shape microchannel are constructed by measuring the two-dimensional velocities on 11 fluid layers from the bottom of microchannel to the top. Based on this, the flow rates are calculated by the discrete integration of velocity distributions on the cross-section of microchannel. The relative errors of the flow rates of the inlet and outlet are all within 3%, and we conclude that the main factors affecting the measurement precision of flow rate include the wall roughness of the microchannel, the spatial resolution of microscopic system and the algorithm of velocity evaluation.

  16. 利用Micro-PIV测量微管道内流量的研究%Study on the Flowrate Mesurement in Microtubes by Micro-PIV

    Institute of Scientific and Technical Information of China (English)

    张永胜; 刘彦军; 王金华

    2011-01-01

    为了解决微管道(水力直径小于1 mm)内流量测量问题,采用Micro-PIV对水力直径为230 μm毛细玻璃管内流量进行测量.实验中对Re=480~2 260范围内流量进行测量,试验结果证明利用该技术完全可能实现微管道内流量精确测量.%In order to solve the problem of measuring the flow rate in microtubes (the hydraulic diameter is under lmm) ,the Micro-PIV is used to measure the fiowrate within the capillary tube,and its hydraulic diameter is 230μm.In the experiment,the fiowrate is measured in the reynolds number range of 480 ~ 2260,and the conclusion is that Micro-PIV technique can be used to measure the fiowrate in the microtubes with high precision.

  17. Direct calculation of the weighting function and depth of correlation in Micro-Particle Image Velocimetry (Micro-PIV) from particle images

    Science.gov (United States)

    Hein, Michael; Wieneke, Bernhard; Seemann, Ralf

    2013-11-01

    Micro-PIV has become the most popular tool to measure flow profiles in microfluidics. When measuring in-plane velocities in a three dimensional flow the measured velocity depends on all particles in the images, even on defocused particles, and is given by a weighted average of the true velocity dx(z) with a weighting function W(z). W(z) depends on the optical setup as well as on the particle diameter and gradients of the flow-profile. The width of W(z) determines the height-extension of the plane in which particles can influence the measurement (Depth of Correlation, DOC). Thus the knowledge of the system dependent W(z) is crucial and can be used to reduce the errors introduced by depth-averaging the velocity field. We determine W(z) and thus the DOC using artificial double images for any given flow profile generated from particle images taken with the same optical setup as used for the PIV measurements. Experimental results for objectives with different numerical apertures (NA), different particle sizes and various out-of-plane gradients will be discussed. The resulting weighting function turns out to be quite asymmetric for air-objectives with high NAs, differing significantly in shape and width (DOC) from existing theoretical predictions.

  18. Experimental study of the application of micro-PIV on the flow characteristics detection of micro-gap rotational flow field

    Science.gov (United States)

    Tang, Fei; Wang, Chunze; Shi, Yupeng; Wang, Xiaohao

    2015-04-01

    For a micro-gap rotational flow field with a large horizontal extent, tiny gap and fast flow velocity, the two-dimensional images shot by the micro-scale Particle ImageVelocimetry(Micro-PIV) technique are not sufficient for the study of local or whole flow characteristics. In this paper, by establishing a test bench of a rotational flow field with the functions of driving, positioning, adjustment and sensing, all the local states of the micro-gap rotational flow field can be obtained by horizontally moving the rotating axis to observe point by point. While measuring some local flow fields, two-dimensional pictures are taken by adjusting the focusing height of the objective lens, and then superposed and interpolated according to their shooting order to obtain a quasi-three-dimensional distribution image of the local flow fields, thus obtaining the flow condition of the vertical section of the flow field. The position of the focusing plane and mutual distance are adjusted to realize the measurement of wall shear force in the flow field, providing a feasible reference method for detecting the rheological property of the gap flow field and the effect of surface drag reduction.

  19. Experimental study of the application of micro-PIV on the flow characteristics detection of micro-gap rotational flow field

    Directory of Open Access Journals (Sweden)

    Fei Tang

    2015-04-01

    Full Text Available For a micro-gap rotational flow field with a large horizontal extent, tiny gap and fast flow velocity, the two-dimensional images shot by the micro-scale Particle ImageVelocimetry(Micro-PIV technique are not sufficient for the study of local or whole flow characteristics. In this paper, by establishing a test bench of a rotational flow field with the functions of driving, positioning, adjustment and sensing, all the local states of the micro-gap rotational flow field can be obtained by horizontally moving the rotating axis to observe point by point. While measuring some local flow fields, two-dimensional pictures are taken by adjusting the focusing height of the objective lens, and then superposed and interpolated according to their shooting order to obtain a quasi-three-dimensional distribution image of the local flow fields, thus obtaining the flow condition of the vertical section of the flow field. The position of the focusing plane and mutual distance are adjusted to realize the measurement of wall shear force in the flow field, providing a feasible reference method for detecting the rheological property of the gap flow field and the effect of surface drag reduction.

  20. Chip, Chip, Hooray!

    Science.gov (United States)

    Kelly, Susan

    2001-01-01

    Presents a science laboratory using different brands of potato chips in which students test their oiliness, size, thickness, saltiness, quality, and cost, then analyze the results to determine the best chip. Gives a brief history of potato chips. (YDS)

  1. Nonparametric Bayesian Clustering of Structural Whole Brain Connectivity in Full Image Resolution

    DEFF Research Database (Denmark)

    Ambrosen, Karen Marie Sandø; Albers, Kristoffer Jon; Dyrby, Tim B.

    2014-01-01

    Diffusion magnetic resonance imaging enables measuring the structural connectivity of the human brain at a high spatial resolution. Local noisy connectivity estimates can be derived using tractography approaches and statistical models are necessary to quantify the brain’s salient structural...... organization. However, statistically modeling these massive structural connectivity datasets is a computational challenging task. We develop a high-performance inference procedure for the infinite relational model (a prominent non-parametric Bayesian model for clustering networks into structurally similar...... groups) that defines structural units at the resolution of statistical support. We apply the model to a network of structural brain connectivity in full image resolution with more than one hundred thousand regions (voxels in the gray-white matter boundary) and around one hundred million connections...

  2. FPGA Based Compact and Efficient Full Image Buffering for Neighborhood Operations

    Directory of Open Access Journals (Sweden)

    KAZMI, M.

    2015-02-01

    Full Text Available Image processing systems based on neighborhood operations i.e. Neighborhood Processing Systems (NPSs are computationally expensive and memory intensive. Field Programmable Gate Array (FPGA based parallel processing architectures accelerate calculations of NPS provided if they have fast external-memory data access by using on-chip data buffers. The conventional data buffers namely full Row Buffers (RBs implemented with FPGA embedded memory resources i.e. Block RAMs (BRAMs are resource inefficient. It makes overall NPS implementation on FPGA expensive and infeasible especially for resource-constraint environment. This paper presents compact and efficient image buffering architecture with an additional feature of pre-fetching. Proposed design fits in minimal BRAMs by using small yet efficient Main Control Unit (MCU. Its optimal multi-rated BRAM data accessing technique reduces BRAM cost to provide multiple pixels of pre-fetched data/clock to NPS in a fixed pattern. It controls and synchronizes BRAMs operations to attain throughput of 1 clock/pixel. Thus our buffer architecture with 66% reduction in BRAM requirement as compared to conventional RBs is capable to support buffering for real time systems with high resolution (1080x1920@62fps. Therefore proposed buffer architecture can suitably replace conventional RB in any real time NPS application.

  3. Atom chips

    CERN Document Server

    Reichel, Jakob

    2010-01-01

    This book provides a stimulating and multifaceted picture of a rapidly developing field. The first part reviews fundamentals of atom chip research in tutorial style, while subsequent parts focus on the topics of atom-surface interaction, coherence on atom chips, and possible future directions of atom chip research. The articles are written by leading researchers in the field in their characteristic and individual styles.

  4. Chips 2020

    CERN Document Server

    2016-01-01

    The release of this second volume of CHIPS 2020 coincides with the 50th anniversary of Moore’s Law, a critical year marked by the end of the nanometer roadmap and by a significantly reduced annual rise in chip performance. At the same time, we are witnessing a data explosion in the Internet, which is consuming 40% more electrical power every year, leading to fears of a major blackout of the Internet by 2020. The messages of the first CHIPS 2020, published in 2012, concerned the realization of quantum steps for improving the energy efficiency of all chip functions. With this second volume, we review these messages and amplify upon the most promising directions: ultra-low-voltage electronics, nanoscale monolithic 3D integration, relevant-data, brain- and human-vision-inspired processing, and energy harvesting for chip autonomy. The team of authors, enlarged by more world leaders in low-power, monolithic 3D, video, and Silicon brains, presents new vistas in nanoelectronics, promising  Moore-like exponential g...

  5. Velocity field measurements in an evaporating sessile droplet by means of micro-PIV technique

    Directory of Open Access Journals (Sweden)

    Yagodnitsyna Anna

    2016-01-01

    Full Text Available Velocity fields are measured in evaporating sessile droplets on two substrates with different contact angles and contact angle hysteresis using micro resolution particle image velocimetry technique. Different flow patterns are observed in different stages of droplet evaporation: a flow with vortices and a radial flow. Flow structure is found to be similar for droplets on different substrates.

  6. Time-Resolved Micro PIV in the Pivoting Area of the Triflo Mechanical Heart Valve.

    Science.gov (United States)

    Vennemann, Bernhard M; Rösgen, Thomas; Carrel, Thierry P; Obrist, Dominik

    2016-09-01

    The Lapeyre-Triflo FURTIVA valve aims at combining the favorable hemodynamics of bioprosthetic heart valves with the durability of mechanical heart valves (MHVs). The pivoting region of MHVs is hemodynamically of special interest as it may be a region of high shear stresses, combined with areas of flow stagnation. Here, platelets can be activated and may form a thrombus which in the most severe case can compromise leaflet mobility. In this study we set up an experiment to replicate the pulsatile flow in the aortic root and to study the flow in the pivoting region under physiological hemodynamic conditions (CO = 4.5 L/min / CO = 3.0 L/min, f = 60 BPM). It was found that the flow velocity in the pivoting region could reach values close to that of the bulk flow during systole. At the onset of diastole the three valve leaflets closed in a very synchronous manner within an average closing time of 55 ms which is much slower than what has been measured for traditional bileaflet MHVs. Hot spots for elevated viscous shear stresses were found at the flanges of the housing and the tips of the leaflet ears. Systolic VSS was maximal during mid-systole and reached levels of up to 40 Pa.

  7. Micro-PIV quantification of capillary blood flow redistribution caused by laser-assisted vascular occlusion

    Science.gov (United States)

    Kurochkin, Maxim A.; Stiukhina, Elena S.; Fedosov, Ivan V.; Postnov, Dmitry E.; Tuchin, Valery V.

    2016-04-01

    We propose μPIV-based technique for quantitative assessment of blood flow redistribution in microcirculatory networks. Our approach is based on per-segment averaging of measured quantities so we can avoid most of problems that are typical for point-wise measurements. The key point of our technique is the digital processing algorithms of recorded data that include: capillary network axial line construction; interrogation regions centering; blood flow velocity local estimate using PIV approach; blood flow velocity calculation by means of averaging over entire vessel segment; the calculation of blood volume flow rate map. We illustrate the application of developed technique with in vivo measurements and blood flow velocity map reconstruction for chorioallantoic membrane (CAM) of chicken embryo, in which the local vascular occlusion was produced using continuous wave laser light irradiation..

  8. Pixel detector readout chip

    CERN Multimedia

    1991-01-01

    Close-up of a pixel detector readout chip. The photograph shows an aera of 1 mm x 2 mm containing 12 separate readout channels. The entire chip contains 1000 readout channels (around 80 000 transistors) covering a sensitive area of 8 mm x 5 mm. The chip has been mounted on a silicon detector to detect high energy particles.

  9. CHIP Reporting in the CPS

    Data.gov (United States)

    U.S. Department of Health & Human Services — CHIP reporting in the CPS is unreliable. Only 10 to 30 percent of those with CHIP (but not Medicaid) report this type of coverage in the CPS. Many with CHIP report...

  10. Chip Multithreaded Consistency Model

    Institute of Scientific and Technical Information of China (English)

    Zu-Song Li; Dan-Dan Huan; Wei-Wu Hu; Zhi-Min Tang

    2008-01-01

    Multithreaded technique is the developing trend of high performance processor. Memory consistency model is essential to the correctness, performance and complexity of multithreaded processor. The chip multithreaded consistency model adapting to multithreaded processor is proposed in this paper. The restriction imposed on memory event ordering by chip multithreaded consistency is presented and formalized. With the idea of critical cycle built by Wei-Wu Hu, we prove that the proposed chip multithreaded consistency model satisfies the criterion of correct execution of sequential consistency model. Chip multithreaded consistency model provides a way of achieving high performance compared with sequential consistency model and ensures the compatibility of software that the execution result in multithreaded processor is the same as the execution result in uniprocessor. The implementation strategy of chip multithreaded consistency model in Godson-2 SMT processor is also proposed. Godson-2 SMT processor supports chip multithreaded consistency model correctly by exception scheme based on the sequential memory access queue of each thread.

  11. UW VLSI chip tester

    Science.gov (United States)

    McKenzie, Neil

    1989-12-01

    We present a design for a low-cost, functional VLSI chip tester. It is based on the Apple MacIntosh II personal computer. It tests chips that have up to 128 pins. All pin drivers of the tester are bidirectional; each pin is programmed independently as an input or an output. The tester can test both static and dynamic chips. Rudimentary speed testing is provided. Chips are tested by executing C programs written by the user. A software library is provided for program development. Tests run under both the Mac Operating System and A/UX. The design is implemented using Xilinx Logic Cell Arrays. Price/performance tradeoffs are discussed.

  12. ALICE chip processor

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    This tiny chip provides data processing for the time projection chamber on ALICE. Known as the ALICE TPC Read Out (ALTRO), this device was designed to minimize the size and power consumption of the TPC front end electronics. This single chip contains 16 low-power analogue-to-digital converters with six million transistors of digital processing and 8 kbits of data storage.

  13. CHIP, CHIP, ARRAY! THREE CHIPS FOR POST-GENOMIC RESEARCH

    Science.gov (United States)

    Cambridge Healthtech Institute recently held the 4th installment of their popular "Lab-on-a-Chip" series in Zurich, Switzerland. As usual, it was enthusiastically received and over 225 people attended the 2-1/2 day meeting to see and hear about some of the latest developments an...

  14. CHIP, CHIP, ARRAY! THREE CHIPS FOR POST-GENOMIC RESEARCH

    Science.gov (United States)

    Cambridge Healthtech Institute recently held the 4th installment of their popular "Lab-on-a-Chip" series in Zurich, Switzerland. As usual, it was enthusiastically received and over 225 people attended the 2-1/2 day meeting to see and hear about some of the latest developments an...

  15. Advanced flip chip packaging

    CERN Document Server

    Lai, Yi-Shao; Wong, CP

    2013-01-01

    Advanced Flip Chip Packaging presents past, present and future advances and trends in areas such as substrate technology, material development, and assembly processes. Flip chip packaging is now in widespread use in computing, communications, consumer and automotive electronics, and the demand for flip chip technology is continuing to grow in order to meet the need for products that offer better performance, are smaller, and are environmentally sustainable. This book also: Offers broad-ranging chapters with a focus on IC-package-system integration Provides viewpoints from leading industry executives and experts Details state-of-the-art achievements in process technologies and scientific research Presents a clear development history and touches on trends in the industry while also discussing up-to-date technology information Advanced Flip Chip Packaging is an ideal book for engineers, researchers, and graduate students interested in the field of flip chip packaging.

  16. CHIP Enrollment Reports

    Data.gov (United States)

    U.S. Department of Health & Human Services — CHIP quarterly and annual statistical enrollment reports. The quarterly reports contain point-in-time and ever enrolled data and the annual reports contain ever...

  17. China's first WLAN chips

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ The wireless local area network (WLAN) chips independently developed by CAS researchers were in the limelight of the recent Electronic Manufacture Exposition held in Suzhou, east China's Jiangsu Province.

  18. Medicaid CHIP ESPC Database

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Environmental Scanning and Program Characteristic (ESPC) Database is in a Microsoft (MS) Access format and contains Medicaid and CHIP data, for the 50 states and...

  19. SU-8 cantilever chip interconnection

    DEFF Research Database (Denmark)

    Johansson, Alicia Charlotte; Janting, Jakob; Schultz, Peter;

    2006-01-01

    the electrodes on the SU-8 chip to a printed circuit board. Here, we present two different methods of electrically connecting an SU-8 chip, which contains a microfluidic network and free-hanging mechanical parts. The tested electrical interconnection techniques are flip chip bonding using underfill or flip chip...... bonding using an anisotropic conductive film (ACF). These are both widely used in the Si industry and might also be used for the large scale interconnection of SU-8 chips. The SU-8 chip, to which the interconnections are made, has a microfluidic channel with integrated micrometer-sized cantilevers...... that can be used for label-free biochemical detection. All the bonding tests are compared with results obtained using similar Si chips. It is found that it is significantly more complicated to interconnect SU-8 than Si cantilever chips primarily due to the softness of SU-8....

  20. Fuzzy Logic Control ASIC Chip

    Institute of Scientific and Technical Information of China (English)

    沈理

    1997-01-01

    A fuzzy logic control VLSI chip,F100,for industry process real-time control has been designed and fabricated with 0.8μm CMOS technology.The chip has the features of simplicity,felexibility and generality.This paper presents the Fuzzy control inrerence method of the chip,its VLSI implementation,and testing esign consideration.

  1. Automated and temperature-controlled micro-PIV measurements enabling long-term-stable microchannel acoustophoresis characterization.

    Science.gov (United States)

    Augustsson, Per; Barnkob, Rune; Wereley, Steven T; Bruus, Henrik; Laurell, Thomas

    2011-12-21

    We present a platform for micro particle image velocimetry (μPIV), capable of carrying out full-channel, temperature-controlled, long-term-stable, and automated μPIV-measurement of microchannel acoustophoresis with uncertainties below 5% and a spatial resolution in the order of 20 μm. A method to determine optimal μPIV-settings for obtaining high-quality results of the spatially inhomogeneous acoustophoretic velocity fields of large dynamical range is presented. In particular we study the dependence of the results on the μPIV interrogation window size and the number of repeated experiments. The μPIV-method was further verified by comparing it with our previously published particle tracking method. Using the μPIV platform we present a series of high-resolution measurements of the acoustophoretic velocity field as a function of the driving frequency, the driving voltage, and the resonator temperature. Finally, we establish a direct and consistent connection between the obtained acoustophoretic velocity fields, and continuous flow mode acoustophoresis, commonly used in applications.

  2. Automated and temperature-controlled micro-PIV measurements enabling long-term-stable microchannel acoustophoresis characterization

    DEFF Research Database (Denmark)

    Augustsson, Per; Barnkob, Rune; Wereley, Steven T.

    2011-01-01

    We present a platform for micro particle image velocimetry (μPIV), capable of carrying out full-channel, temperature-controlled, long-term-stable, and automated μPIV-measurement of microchannel acoustophoresis with uncertainties below 5% and a spatial resolution in the order of 20 μm. A method...... to determine optimal μPIV-settings for obtaining high-quality results of the spatially inhomogeneous acoustophoretic velocity fields of large dynamical range is presented. In particular we study the dependence of the results on the μPIV interrogation window size and the number of repeated experiments. The μPIV......-method was further verified by comparing it with our previously published particle tracking method. Using the μPIV platform we present a series of high-resolution measurements of the acoustophoretic velocity field as a function of the driving frequency, the driving voltage, and the resonator temperature. Finally, we...

  3. Valveless pumping mechanics of the embryonic heart during cardiac looping: Pressure and flow through micro-PIV.

    Science.gov (United States)

    Bark, D L; Johnson, B; Garrity, D; Dasi, L P

    2017-01-04

    Cardiovascular development is influenced by the flow-induced stress environment originating from cardiac biomechanics. To characterize the stress environment, it is necessary to quantify flow and pressure. Here, we quantify the flow field in a developing zebrafish heart during the looping stage through micro-particle imaging velocimetry and by analyzing spatiotemporal plots. We further build upon previous methods to noninvasively quantify the pressure field at a low Reynolds number using flow field data for the first time, while also comparing the impact of viscosity models. Through this method, we show that the atrium builds up pressure to ~0.25mmHg relative to the ventricle during atrial systole and that atrial expansion creates a pressure difference of ~0.15mmHg across the atrium, resulting in efficient cardiac pumping. With these techniques, it is possible to noninvasively fully characterize hemodynamics during heart development.

  4. Calculation of the weighting function and determination of the depth of correlation in micro-PIV from experimental particle images

    Science.gov (United States)

    Hein, M.; Wieneke, B.; Seemann, R.

    2014-08-01

    Micro-particle image velocimetry (µPIV) uses volume-illumination and imaging of particles through a single microscope objective. Displacement fields are obtained by image correlation and depend on all imaged particles, including defocused particles. The measured in-plane displacement is a weighted spatial average of the true displacement, with a weighting function W(z) that depends on the optical system and flow-gradients. The characteristic width of the weighting function W(z) is also referred to as depth of correlation (DOC) and is a measure up to which distance from the focal plane particles influence the measurement, which is crucial for the interpretation of measured flow fields. We present procedures to determine the W(z) from which the DOC can be derived and to directly determine the DOC from PIV double images, generated from experimentally recorded particle images. Both procedures provide comparable DOC results. Our approach allows determination of the DOC and W(z)as a function of out of plane gradients, optical setup parameters and PIV-analysis parameters. Experimental results for different objectives and particle sizes are discussed, revealing substantial deviations from theoretical predictions for high NA air-objectives. Moreover, using the determined weighting function W(z), the correction of measured flow profiles for errors introduced by the spatial averaging is demonstrated.

  5. Logics for Physarum Chips

    Directory of Open Access Journals (Sweden)

    Schumann Andrew

    2016-03-01

    Full Text Available The paper considers main features of two groups of logics for biological devices, called Physarum Chips, based on the plasmodium. Let us recall that the plasmodium is a single cell with many diploid nuclei. It propagates networks by growing pseudopodia to connect scattered nutrients (pieces of food. As a result, we deal with a kind of computing. The first group of logics for Physarum Chips formalizes the plasmodium behaviour under conditions of nutrient-poor substrate. This group can be defined as standard storage modification machines. The second group of logics for Physarum Chips covers the plasmodium computing under conditions of nutrient-rich substrate. In this case the plasmodium behaves in a massively parallel manner and propagates in all possible directions. The logics of the second group are unconventional and deal with non-well-founded data such as infinite streams.

  6. Trapping molecules on chips

    CERN Document Server

    Santambrogio, Gabriele

    2015-01-01

    In the last years, it was demonstrated that neutral molecules can be loaded on a microchip directly from a supersonic beam. The molecules are confined in microscopic traps that can be moved smoothly over the surface of the chip. Once the molecules are trapped, they can be decelerated to a standstill, for instance, or pumped into selected quantum states by laser light or microwaves. Molecules are detected on the chip by time-resolved spatial imaging, which allows for the study of the distribution in the phase space of the molecular ensemble.

  7. Cytometer on a Chip

    Science.gov (United States)

    Fernandez, Salvador M.

    2011-01-01

    A cytometer now under development exploits spatial sorting of sampled cells on a microarray chip followed by use of grating-coupled surface-plasmon-resonance imaging (GCSPRI) to detect the sorted cells. This cytometer on a chip is a prototype of contemplated future miniature cytometers that would be suitable for rapidly identifying pathogens and other cells of interest in both field and laboratory applications and that would be attractive as alternatives to conventional flow cytometers. The basic principle of operation of a conventional flow cytometer requires fluorescent labeling of sampled cells, stringent optical alignment of a laser beam with a narrow orifice, and flow of the cells through the orifice, which is subject to clogging. In contrast, the principle of operation of the present cytometer on a chip does not require fluorescent labeling of cells, stringent optical alignment, or flow through a narrow orifice. The basic principle of operation of the cytometer on a chip also reduces the complexity, mass, and power of the associated laser and detection systems, relative to those needed in conventional flow cytometry. Instead of making cells flow in single file through a narrow flow orifice for sequential interrogation as in conventional flow cytometry, a liquid containing suspended sampled cells is made to flow over the front surface of a microarray chip on which there are many capture spots. Each capture spot is coated with a thin (approximately 50-nm) layer of gold that is, in turn, coated with antibodies that bind to cell-surface molecules characteristic of one the cell species of interest. The multiplicity of capture spots makes it possible to perform rapid, massively parallel analysis of a large cell population. The binding of cells to each capture spot gives rise to a minute change in the index of refraction at the surface of the chip. This change in the index of refraction is what is sensed in GCSPRI, as described briefly below. The identities of the

  8. Mikrofluidik-Chips

    NARCIS (Netherlands)

    Verpoorte, E.; Lichtenberg, J.

    2000-01-01

    Microfluidic chips are becoming the new paradigm for chemical processing and analysis in the laboratory. Hair-fine channels made in planar substrates using silicon processing technologies replace beakers and tubing for automated liquid transport and handling on a sub-μ L scale. Reduced conduit diame

  9. MICROELECTRONICS: Flip the Chip.

    Science.gov (United States)

    Wong, C P; Luo, S; Zhang, Z

    2000-12-22

    As integrated circuit fabrication advances rapidly and the market for faster, lighter, smaller, yet less expensive electronic products accelerates, electronic packaging faces its own challenges. In this Perspective, Wong, Luo, and Zhang describe recent advances in flip chip packaging. This technology has many advantages over the conventional wire bonding technology and offers the possibility of low-cost electronic assembly for modern electronic products.

  10. Mikrofluidik-Chips

    NARCIS (Netherlands)

    Verpoorte, E.; Lichtenberg, J.

    2000-01-01

    Microfluidic chips are becoming the new paradigm for chemical processing and analysis in the laboratory. Hair-fine channels made in planar substrates using silicon processing technologies replace beakers and tubing for automated liquid transport and handling on a sub-μ L scale. Reduced conduit

  11. Radiometer on a Chip

    Science.gov (United States)

    Chattopadhyay, Goutam; Gill, John J.; Mehdi, Imran; Lee, Choonsup; Schlecht, Erich T.; Skalare, Anders; Ward, John S.; Siegel, Peter H.; Thomas, Bertrand C.

    2009-01-01

    The radiometer on a chip (ROC) integrates whole wafers together to p rovide a robust, extremely powerful way of making submillimeter rece ivers that provide vertically integrated functionality. By integratin g at the wafer level, customizing the interconnects, and planarizing the transmission media, it is possible to create a lightweight asse mbly performing the function of several pieces in a more conventiona l radiometer.

  12. [Wood chip alveolitis].

    Science.gov (United States)

    Müller-Wening, D; Renck, T; Neuhauss, M

    1999-07-01

    A 52 year old farmer was referred to us for investigation of suspected farmer's lung. For many years the farmer had been exposed to hay, straw, pigeons, and fuel chip dust. Under exertion he suffered from shortness of breath. In the farmer's own fuel chips we could identify Aspergillus fumigatus, Paecilomyces species and Mucor species. In the farmer's blood we found IgG-antibodies against his own fuel chips, thermophilic actinomycetes, Penicillium species, Mucor species and Aspergillus fumigatus. We did not detect any IgG-antibodies against pigeon serum or pigeon faeces. In order to determine the responsible allergen we performed two challenge tests. In the first test the farmer had to inhale his own hay and straw dust for one hour. This provocation was negative. A second one-hour inhalative challenge was carried out 16 days later using his own fuel chips. This time he experienced significant pulmonary and systemic reactions: body temperature rose by 3.3 degrees C, leucocytes by 12,200/mm3; PO2 fell by 39.4 mmHg, vital capacity by 52%, DLCO by 36%. After the challenge the farmer complained of coughing and dyspnoea. Rales could be heard on auscultation, and an interstitial infiltrate was seen to develop on chest x-rays. After the challenge the patient had to be treated with oxygen and systemic corticosteroids. We diagnosed a fuel chip-induced exogenous allergic alveolitis (EAA). Eight days later the parameters were back to normal and the farmer was discharged from our hospital with further corticosteroid medication. This method of inhalative provocation is very important in diagnosing an EAA. Problems arise when the mode and duration of exposure to substances has to be chosen. Because of the risk of severe reactions, inhalative provocations relating to EAAs should only be performed in special centres with an intensive care unit. In this paper we present a diagnosis of fuel chip lung, which is rarely seen in Germany. However, with the rising use of fuel chips as

  13. Preservation of forest wood chips

    Energy Technology Data Exchange (ETDEWEB)

    Kofman, P.D.; Thomsen, I.M.; Ohlsson, C.; Leer, E.; Ravn Schmidt, E.; Soerensen, M.; Knudsen, P.

    1999-01-01

    As part of the Danish Energy Research Programme on biomass utilisation for energy production (EFP), this project concerns problems connected to the handling and storing of wood chips. In this project, the possibility of preserving wood chips of the Norway Spruce (Picea Abies) is addressed, and the potential improvements by anaerobic storage are tested. Preservation of wood chips aims at reducing dry matter losses from extensive heating during storage and to reduce production of fungal spores. Fungal spores pose a health hazards to workers handling the chips. Further the producers of wood chips are interested in such a method since it would enable them to give a guarantee for the delivery of homogeneous wood chips also during the winter period. Three different types of wood chips were stored airtight and further one of these was stored in accordance with normal practise and use as reference. The results showed that airtight storage had a beneficial impact on the quality of the chips: no redistribution of moisture, low dry matter losses, unfavourable conditions for microbial activity of most fungi, and the promotion of yeasts instead of fungi with airborne spores. Likewise the firing tests showed that no combustion problems, and no increased risk to the environment or to the health of staff is caused by anaerobic storage of wood chips. In all, the tests of the anaerobic storage method of forest wood chips were a success and a large-scale test of the method will be carried out in 1999. (au)

  14. Experiment list: SRX122496 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available || chip antibody=Rel || treatment=LPS || time=120 min || chip antibody manufacturer 1=Santa Cruz || chip ant...ibody catalog number 1=sc-71 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc

  15. Hot Extrusion of Aluminum Chips

    Science.gov (United States)

    Tekkaya, A. Erman; Güley, Volkan; Haase, Matthias; Jäger, Andreas

    The process of hot extrusion is a promising approach for the direct recycling of aluminum machining chips to aluminum profiles. The presented technology is capable of saving energy, as remelting of aluminum chips can be avoided. Depending on the deformation route and process parameters, the chip-based aluminum extradates showed mechanical properties comparable or superior to cast aluminum billets extruded under the same conditions. Using different metal flow schemes utilizing different extrusion dies the mechanical properties of the profiles extruded from chips can be improved. The energy absorption capacity of the profiles the rectangular hollow profiles extruded from chips and as-cast billets were analyzed using the drop hammer test set-up. The formability of the profiles extruded from chips and as-cast material were compared using tube bending tests in a three-roller-bending machine.

  16. Nanoparticle Reactions on Chip

    Science.gov (United States)

    Köhler, J. M.; Kirner, Th.; Wagner, J.; Csáki, A.; Möller, R.; Fritzsche, W.

    The handling of heterogenous systems in micro reactors is difficult due to their adhesion and transport behaviour. Therefore, the formation of precipitates and gas bubbles has to be avoided in micro reaction technology, in most cases. But, micro channels and other micro reactors offer interesting possibilities for the control of reaction conditions and transport by diffusion and convection due to the laminar flow caused by small Reynolds numbers. This can be used for the preparation and modification of objects, which are much smaller than the cross section of microchannels. The formation of colloidal solutions and the change of surface states of nano particles are two important tasks for the application of chip reactors in nanoparticle technology. Some concepts for the preparation and reaction of nanoparticles in modular chip reactor arrangements will be discussed.

  17. Microfluidic on chip viscometers.

    Science.gov (United States)

    Chevalier, J; Ayela, F

    2008-07-01

    We present the design and the process of fabrication of micromachined capillary on chip rheometers which have performed wall shear stress and shear rate measurements on silicon oil and ethanol-based nanofluids. The originality of these devices comes from the fact that local pressure drop measurements are performed inside the microchannels. Thus, the advantage over existing microviscometers is that they can be used with the fluid under test alone; no reference fluid nor posttreatment of the data are needed. Each on chip viscometer consists of anodically bonded silicon-Pyrex derivative microchannels equipped with local probes. The anodic bonding allows to reach relatively high pressure levels (up to approximately 10 bars) in the channels, and a broad range of shear stress and shear rate values is attainable. Dielectrophoretic and electrorheological effects can be highlighted by employing alternate microstripe electrodes patterned onto the inner side of the Pyrex wall.

  18. Amdahl 470 Chip Package

    CERN Multimedia

    1975-01-01

    In the late 70s the larger IBM computers were water cooled. Amdahl, an IBM competitor, invented an air cooling technology for it's computers. His company worked hard, developing a computer that was faster and less expensive than the IBM System/360 mainframe computer systems. This object contains an actual Amdahl series 470 computer logic chip with an air cooling device mounted on top. The package leads and cooling tower are gold-plated.

  19. On-chip data communication

    NARCIS (Netherlands)

    Schinkel, Daniel

    2011-01-01

    On-chip data communication is an active research area, as interconnects are rapidly becoming a speed, power and reliability bottleneck for digital CMOS systems. Especially for global interconnects that have to span large parts of a chip, there is an increasing gap between transistor speed and interc

  20. On-chip data communication

    NARCIS (Netherlands)

    Schinkel, Daniel

    2011-01-01

    On-chip data communication is an active research area, as interconnects are rapidly becoming a speed, power and reliability bottleneck for digital CMOS systems. Especially for global interconnects that have to span large parts of a chip, there is an increasing gap between transistor speed and

  1. Ion chromatography on-chip.

    Science.gov (United States)

    Murrihy, J P; Breadmore, M C; Tan, A; McEnery, M; Alderman, J; O'Mathuna, C; O'Neill, A P; O'Brien, P; Avdalovic, N; Haddad, P R; Glennon, J D; Advoldvic, N

    2001-07-27

    On-chip separation of inorganic anions by ion-exchange chromatography was realized. Micro separation channels were fabricated on a silicon wafer and sealed with a Pyrex cover plate using standard photolithography, wet and dry chemical etching, and anodic bonding techniques. Quaternary ammonium latex particles were employed for the first time to coat the separation channels on-chip. Owing to the narrow depths of the channels on the chip, 0.5-10 microm, there were more interactions of the analytes with the stationary phase on the chip than in a 50-microm I.D. capillary. With off-chip injection (20 nl) and UV detection, NO2-, NO3-, I-, and thiourea were separated using 1 mM KCl as the eluent. The linear ranges for NO2- and NO3- are from 5 to 1000 microM with the detection limits of 0.5 microM.

  2. Ultra-thin chip technology and applications

    CERN Document Server

    2010-01-01

    Ultra-thin chips are the "smart skin" of a conventional silicon chip. This book shows how very thin and flexible chips can be fabricated and used in many new applications in microelectronics, microsystems, biomedical and other fields. It provides a comprehensive reference to the fabrication technology, post processing, characterization and the applications of ultra-thin chips.

  3. Focal-plane sensor-processor chips

    CERN Document Server

    Zarándy, Ákos

    2011-01-01

    Focal-Plane Sensor-Processor Chips explores both the implementation and application of state-of-the-art vision chips. Presenting an overview of focal plane chip technology, the text discusses smart imagers and cellular wave computers, along with numerous examples of current vision chips.

  4. Towards Dependable Network-on-Chip Architectures

    NARCIS (Netherlands)

    Chen, C.

    2015-01-01

    The aggressive semiconductor technology scaling provides the means for doubling the amount of transistors on a single chip each and every 18 months. To efficiently utilize these vast chip resources, Multi-Processor Systems on Chip (MPSoCs) integrated with a Network-on-Chip (NoC) communication infras

  5. Repairable chip bonding/interconnect process

    Science.gov (United States)

    Bernhardt, Anthony F.; Contolini, Robert J.; Malba, Vincent; Riddle, Robert A.

    1997-01-01

    A repairable, chip-to-board interconnect process which addresses cost and testability issues in the multi-chip modules. This process can be carried out using a chip-on-sacrificial-substrate technique, involving laser processing. This process avoids the curing/solvent evolution problems encountered in prior approaches, as well is resolving prior plating problems and the requirements for fillets. For repairable high speed chip-to-board connection, transmission lines can be formed on the sides of the chip from chip bond pads, ending in a gull wing at the bottom of the chip for subsequent solder.

  6. COMPARISON OF SAMPLE PREPARATION METHODS FOR CHIP-CHIP ASSAYS

    OpenAIRE

    O'Geen, Henriette; Nicolet, Charles M.; Blahnik, Kim; Green, Roland; Farnham, Peggy J.

    2006-01-01

    A single ChIP sample does not provide enough DNA for hybridization to a genomic tiling array. A commonly used technique for amplifying the DNA obtained from ChIP assays is linker-mediated PCR (LMPCR). However, using this amplification method, we could not identify Oct4 binding sites on genomic tiling arrays representing 1% of the human genome (ENCODE arrays). In contrast, hybridization of a pool of 10 ChIP samples to the arrays produced reproducible binding patterns and low background signals...

  7. Chips with everything

    CERN Document Server

    CERN. Geneva

    2007-01-01

    In March 1972, Sir Robin Saxby gave a talk to the Royal Television Society called 'TV and Chips' about a 'state of the art' integrated circuit, containing 50 resistors and 50 transistors. Today's 'state of the art' chips contain up to a billion transistors. This enormous leap forward illustrates how dramatically the semiconductor industry has evolved in the past 34 years. The next 10 years are predicted to bring times of turbulent change for the industry, as more and more digital devices are used around the world. In this talk, Sir Robin will discuss the history of the Microchip Industry in parallel with ARM's history, demonstrating how a small European start-up can become a world player in the IT sector. He will also present his vision of important applications and developments in the next 20 years that are likely to become even more pervasive than the mobile phone is today, and will provide anecdotes and learning points from his own experience at ARM. About ARM: Sir Robin and a group of designers from Acorn...

  8. Experiment list: SRX122568 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ip antibody=Stat2 || treatment=LPS || time=120 min || chip antibody manufacturer 1=Abcam || chip antibody catalog... number 1=ab53149 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-839 h

  9. Experiment list: SRX122522 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ntibody=Irf2 || treatment=LPS || time=60 min || chip antibody manufacturer 1=Abcam || chip antibody catalog ...number 1=ab65048 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-498 http://

  10. Experiment list: SRX122566 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available antibody=Stat2 || treatment=LPS || time=0 min || chip antibody manufacturer 1=Abcam || chip antibody catalog... number 1=ab53149 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-839 http:/

  11. Experiment list: SRX122406 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available antibody=Irf1 || treatment=LPS || time=0 min || chip antibody manufacturer 1=Abcam || chip antibody catalog... number 1=ab52520 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-640 http:/

  12. Experiment list: SRX122415 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ntibody=Junb || treatment=LPS || time=30 min || chip antibody manufacturer 1=Abcam || chip antibody catalog ...number 1=ab28838 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-46 http://d

  13. Experiment list: SRX214071 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Undifferentiated || treatment=Overexpress Sox2-V5 tagged || cell line=KH2 || chip antibody 1=none || chip antibody manufacture...r 1=none || chip antibody 2=V5 || chip antibody manufacturer 2=

  14. Experiment list: SRX122416 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ntibody=Junb || treatment=LPS || time=60 min || chip antibody manufacturer 1=Abcam || chip antibody catalog ...number 1=ab28838 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-46 http://d

  15. Experiment list: SRX214073 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ge=Undifferentiated || treatment=Overexpress Sox2KE-V5 tagged || cell line=KH2 || chip antibody 1=none || chip antibody manufacture...r 1=none || chip antibody 2=V5 || chip antibody manufacture

  16. Experiment list: SRX214070 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available =Undifferentiated || treatment=Overexpress Sox2-V5 tagged || cell line=KH2 || chip antibody 1=none || chip antibody manufacture...r 1=none || chip antibody 2=V5 || chip antibody manufacturer 2

  17. Experiment list: SRX214075 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available age=Undifferentiated || treatment=Overexpress Sox17EK-V5 tagged || cell line=KH2 || chip antibody 1=none || chip antibody manufacture...r 1=none || chip antibody 2=V5 || chip antibody manufacture

  18. Experiment list: SRX122413 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available antibody=Junb || treatment=LPS || time=120 min || chip antibody manufacturer 1=Abcam || chip antibody catalo...g number 1=ab28838 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-46 http:/

  19. Experiment list: SRX214085 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available entiated || cell line=KH2 || chip antibody 1=none || chip antibody manufacturer 1=none || chip antibody 2=none || chip antibody manuf...acturer 2=none http://dbarchive.biosciencedbc.jp/kyushu-

  20. Experiment list: SRX122412 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available antibody=Junb || treatment=LPS || time=120 min || chip antibody manufacturer 1=Abcam || chip antibody catalo...g number 1=ab28838 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-46 http:/

  1. Experiment list: SRX122520 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ntibody=Irf2 || treatment=LPS || time=30 min || chip antibody manufacturer 1=Abcam || chip antibody catalog ...number 1=ab65048 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-498 http://

  2. Experiment list: SRX122417 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ntibody=Junb || treatment=LPS || time=60 min || chip antibody manufacturer 1=Abcam || chip antibody catalog ...number 1=ab28838 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-46 http://d

  3. Experiment list: SRX122565 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available antibody=Stat2 || treatment=LPS || time=0 min || chip antibody manufacturer 1=Abcam || chip antibody catalog... number 1=ab53149 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-839 http:/

  4. Experiment list: SRX122523 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ntibody=Irf2 || treatment=LPS || time=60 min || chip antibody manufacturer 1=Abcam || chip antibody catalog ...number 1=ab65048 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-498 http://

  5. Experiment list: SRX122521 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ntibody=Irf2 || treatment=LPS || time=30 min || chip antibody manufacturer 1=Abcam || chip antibody catalog ...number 1=ab65048 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-498 http://

  6. Experiment list: SRX214086 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available entiated || cell line=KH2 || chip antibody 1=none || chip antibody manufacturer 1=none || chip antibody 2=none || chip antibody manuf...acturer 2=none http://dbarchive.biosciencedbc.jp/kyushu-

  7. Experiment list: SRX214067 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available fferentiated || cell line=F9 || chip antibody 1=Pou5f1/Oct4 || chip antibody manufacture...r 1=Santa Cruz || chip antibody 2=none || chip antibody manufacturer 2=none http://dbarchive.bioscien

  8. Experiment list: SRX214072 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available e=Undifferentiated || treatment=Overexpress Sox2KE-V5 tagged || cell line=KH2 || chip antibody 1=none || chip antibody manufacture...r 1=none || chip antibody 2=V5 || chip antibody manufacture

  9. Experiment list: SRX122485 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available antibody=Atf3 || treatment=LPS || time=120 min || chip antibody manufacturer 1=Santa Cruz || chip antibody ...catalog number 1=sc-188 || chip antibody manufacturer 2=Abcam || chip antibody catalog number 2=ab70005-100

  10. Experiment list: SRX122414 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ntibody=Junb || treatment=LPS || time=30 min || chip antibody manufacturer 1=Abcam || chip antibody catalog ...number 1=ab28838 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-46 http://d

  11. Experiment list: SRX214074 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ge=Undifferentiated || treatment=Overexpress Sox17EK-V5 tagged || cell line=KH2 || chip antibody 1=none || chip antibody manufacture...r 1=none || chip antibody 2=V5 || chip antibody manufacture

  12. Packaging commercial CMOS chips for lab on a chip integration.

    Science.gov (United States)

    Datta-Chaudhuri, Timir; Abshire, Pamela; Smela, Elisabeth

    2014-05-21

    Combining integrated circuitry with microfluidics enables lab-on-a-chip (LOC) devices to perform sensing, freeing them from benchtop equipment. However, this integration is challenging with small chips, as is briefly reviewed with reference to key metrics for package comparison. In this paper we present a simple packaging method for including mm-sized, foundry-fabricated dies containing complementary metal oxide semiconductor (CMOS) circuits within LOCs. The chip is embedded in an epoxy handle wafer to yield a level, large-area surface, allowing subsequent photolithographic post-processing and microfluidic integration. Electrical connection off-chip is provided by thin film metal traces passivated with parylene-C. The parylene is patterned to selectively expose the active sensing area of the chip, allowing direct interaction with a fluidic environment. The method accommodates any die size and automatically levels the die and handle wafer surfaces. Functionality was demonstrated by packaging two different types of CMOS sensor ICs, a bioamplifier chip with an array of surface electrodes connected to internal amplifiers for recording extracellular electrical signals and a capacitance sensor chip for monitoring cell adhesion and viability. Cells were cultured on the surface of both types of chips, and data were acquired using a PC. Long term culture (weeks) showed the packaging materials to be biocompatible. Package lifetime was demonstrated by exposure to fluids over a longer duration (months), and the package was robust enough to allow repeated sterilization and re-use. The ease of fabrication and good performance of this packaging method should allow wide adoption, thereby spurring advances in miniaturized sensing systems.

  13. Whole-Teflon microfluidic chips

    National Research Council Canada - National Science Library

    Kangning Ren; Wen Dai; Jianhua Zhou; Jing Su; Hongkai Wu

    2011-01-01

    .... In this work, we present a convenient strategy for fabricating whole-Teflon microfluidic chips with integrated valves that show outstanding inertness to various chemicals and extreme resistance against all solvents...

  14. On chip shapeable optical tweezers

    National Research Council Canada - National Science Library

    Renaut, C; Cluzel, B; Dellinger, J; Lalouat, L; Picard, E; Peyrade, D; Hadji, E; de Fornel, F

    2013-01-01

    Particles manipulation with optical forces is known as optical tweezing. While tweezing in free space with laser beams was established in the 1980s, integrating the optical tweezers on a chip is a challenging task...

  15. S-Chip Technical Assistance

    Data.gov (United States)

    U.S. Department of Health & Human Services — The page will provide access to reports and other published products designed to assist states with complicated S-Chip technical issues. The reports and products...

  16. Tunable on chip optofluidic laser

    DEFF Research Database (Denmark)

    Bakal, Avraham; Vannahme, Christoph; Kristensen, Anders

    2016-01-01

    On chip tunable laser is demonstrated by realizing a microfluidic droplet array. The periodicity is controlled by the pressure applied to two separate inlets, allowing to tune the lasing frequency over a broad spectral range.......On chip tunable laser is demonstrated by realizing a microfluidic droplet array. The periodicity is controlled by the pressure applied to two separate inlets, allowing to tune the lasing frequency over a broad spectral range....

  17. Universal Fingerprinting Chip Server

    Science.gov (United States)

    Casique-Almazán, Janet; Larios-Serrato, Violeta; Olguín-Ruíz, Gabriela Edith; Sánchez-Vallejo, Carlos Javier; Maldonado-Rodríguez, Rogelio; Méndez-Tenorio, Alfonso

    2012-01-01

    The Virtual Hybridization approach predicts the most probable hybridization sites across a target nucleic acid of known sequence, including both perfect and mismatched pairings. Potential hybridization sites, having a user-defined minimum number of bases that are paired with the oligonucleotide probe, are first identified. Then free energy values are evaluated for each potential hybridization site, and if it has a calculated free energy of equal or higher negative value than a user-defined free energy cut-off value, it is considered as a site of high probability of hybridization. The Universal Fingerprinting Chip Applications Server contains the software for visualizing predicted hybridization patterns, which yields a simulated hybridization fingerprint that can be compared with experimentally derived fingerprints or with a virtual fingerprint arising from a different sample. Availability http://bioinformatica.homelinux.org/UFCVH/ PMID:22829736

  18. Handling of fuel chips - a health problem

    Energy Technology Data Exchange (ETDEWEB)

    Stroemquist, L.H.; Blomqvist, G.; Karlsson, E.; Vincent, A.; Lundgren, R.; Eliasson, L.

    1980-01-01

    An investigation has been made about health problems and occurrence of mold in connection with handling of fuel chips. The investigation was composed of three different parts. First, an inquiry was made to chip stokers about handling, storage etc. of chips as well as possible medical trouble. The answers indicated that symptoms on allergic alveolitis are common among chip stokers, 13% of the answers. Second, a determination of the proportion of living airborne colony-forming mold fungi was made at some chip using units. Third, a pilot study was made to examine the possibilities to improve storability of fuel chips using high-temperature drying.

  19. 75 FR 16149 - Medicaid and CHIP Programs; Meeting of the CHIP Working Group-April 26, 2010

    Science.gov (United States)

    2010-03-31

    ... Administration Medicaid and CHIP Programs; Meeting of the CHIP Working Group-- April 26, 2010 AGENCIES: Centers...-Sponsored Coverage Coordination Working Group (referred to as the ``CHIP Working Group''). The CHIP Working... Medicaid, CHIP, and Employer-Sponsored Coverage Coordination Working Group (``CHIP Working......

  20. Process for 3D chip stacking

    Science.gov (United States)

    Malba, V.

    1998-11-10

    A manufacturable process for fabricating electrical interconnects which extend from a top surface of an integrated circuit chip to a sidewall of the chip using laser pantography to pattern three dimensional interconnects. The electrical interconnects may be of an L-connect or L-shaped type. The process implements three dimensional (3D) stacking by moving the conventional bond or interface pads on a chip to the sidewall of the chip. Implementation of the process includes: (1) holding individual chips for batch processing, (2) depositing a dielectric passivation layer on the top and sidewalls of the chips, (3) opening vias in the dielectric, (4) forming the interconnects by laser pantography, and (5) removing the chips from the holding means. The process enables low cost manufacturing of chips with bond pads on the sidewalls, which enables stacking for increased performance, reduced space, and higher functional per unit volume. 3 figs.

  1. Process for 3D chip stacking

    Science.gov (United States)

    Malba, Vincent

    1998-01-01

    A manufacturable process for fabricating electrical interconnects which extend from a top surface of an integrated circuit chip to a sidewall of the chip using laser pantography to pattern three dimensional interconnects. The electrical interconnects may be of an L-connect or L-shaped type. The process implements three dimensional (3D) stacking by moving the conventional bond or interface pads on a chip to the sidewall of the chip. Implementation of the process includes: 1) holding individual chips for batch processing, 2) depositing a dielectric passivation layer on the top and sidewalls of the chips, 3) opening vias in the dielectric, 4) forming the interconnects by laser pantography, and 5) removing the chips from the holding means. The process enables low cost manufacturing of chips with bond pads on the sidewalls, which enables stacking for increased performance, reduced space, and higher functional per unit volume.

  2. Lab-on-a-Chip

    Science.gov (United States)

    2004-01-01

    Labs on chips are manufactured in many shapes and sizes and can be used for numerous applications, from medical tests to water quality monitoring to detecting the signatures of life on other planets. The eight holes on this chip are actually ports that can be filled with fluids or chemicals. Tiny valves control the chemical processes by mixing fluids that move in the tiny channels that look like lines, connecting the ports. Scientists at NASA's Marshall Space Flight Center (MSFC) in Huntsville, Alabama designed this chip to grow biological crystals on the International Space Station. Through this research, they discovered that this technology is ideally suited for solving the challenges of the Vision for Space Exploration. For example, thousands of chips the size of dimes could be loaded on a Martian rover looking for biosignatures of past or present life. Other types of chips could be placed in handheld devices used to monitor microbes in water or to quickly conduct medical tests on astronauts. (NASA/MSFC/D.Stoffer)

  3. Optical lattice on an atom chip

    DEFF Research Database (Denmark)

    Gallego, D.; Hofferberth, S.; Schumm, Thorsten

    2009-01-01

    Optical dipole traps and atom chips are two very powerful tools for the quantum manipulation of neutral atoms. We demonstrate that both methods can be combined by creating an optical lattice potential on an atom chip. A red-detuned laser beam is retroreflected using the atom chip surface as a high......-quality mirror, generating a vertical array of purely optical oblate traps. We transfer thermal atoms from the chip into the lattice and observe cooling into the two-dimensional regime. Using a chip-generated Bose-Einstein condensate, we demonstrate coherent Bloch oscillations in the lattice....

  4. Chip Advancer For GPS Receiver

    Science.gov (United States)

    Meehan, Thomas K.; Srinivasan, Jeffrey M.; Thomas, J. Brooks

    1989-01-01

    Instrument errors made negligible. For each integration interval, both delay and rate of change of delay initialized to small fraction of chip - for example, to order of 10 to the negative 7th power - thereby making feedback control and extraction of delay highly accurate and flexible. With appropriate selection of sampling rate relative to chip rate, commensurability errors reduced to extremely small levels. In Global Positioning System (GPS) receiver, pseudorandom code sequence generated by simple digital logic incorporating effects of time, delay, and rate of change of delay. Flexibility in starting time and sum interval very useful in aligning correlation interval with beginnings and endings of data bits.

  5. Programmable Multi-Chip Module

    Science.gov (United States)

    Kautz, David; Morgenstern, Howard; Blazek, Roy J.

    2004-11-16

    A multi-chip module comprising a low-temperature co-fired ceramic substrate having a first side on which are mounted active components and a second side on which are mounted passive components, wherein this segregation of components allows for hermetically sealing the active components with a cover while leaving accessible the passive components, and wherein the passive components are secured using a reflow soldering technique and are removable and replaceable so as to make the multi-chip module substantially programmable with regard to the passive components.

  6. Atom chip gravimeter

    Science.gov (United States)

    Schubert, Christian; Abend, Sven; Gebbe, Martina; Gersemann, Matthias; Ahlers, Holger; Müntinga, Hauke; Matthias, Jonas; Sahelgozin, Maral; Herr, Waldemar; Lämmerzahl, Claus; Ertmer, Wolfgang; Rasel, Ernst

    2016-04-01

    Atom interferometry has developed into a tool for measuring rotations [1], accelerations [2], and testing fundamental physics [3]. Gravimeters based on laser cooled atoms demonstrated residual uncertainties of few microgal [2,4] and were simplified for field applications [5]. Atomic gravimeters rely on the interference of matter waves which are coherently manipulated by laser light fields. The latter can be interpreted as rulers to which the position of the atoms is compared. At three points in time separated by a free evolution, the light fields are pulsed onto the atoms. First, a coherent superposition of two momentum states is produced, then the momentum is inverted, and finally the two trajectories are recombined. Depending on the acceleration the atoms experienced, the number of atoms detected in the output ports will change. Consequently, the acceleration can be determined from the output signal. The laser cooled atoms with microkelvin temperatures used in state-of-the-art gravimeters impose limits on the accuracy [4]. Therefore, ultra-cold atoms generated by Bose-Einstein condensation and delta-kick collimation [6,7] are expected to be the key for further improvements. These sources suffered from a low flux implying an incompatible noise floor, but a competitive performance was demonstrated recently with atom chips [8]. In the compact and robust setup constructed for operation in the drop tower [6] we demonstrated all steps necessary for an atom chip gravimeter with Bose-Einstein condensates in a ground based operation. We will discuss the principle of operation, the current performance, and the perspectives to supersede the state of the art. The authors thank the QUANTUS cooperation for contributions to the drop tower project in the earlier stages. This work is supported by the German Space Agency (DLR) with funds provided by the Federal Ministry for Economic Affairs and Energy (BMWi) due to an enactment of the German Bundestag under grant numbers DLR 50WM

  7. Research on security vulnerability of chip

    Science.gov (United States)

    Chen, Zhifeng; Li, Qingbao; Li, Zhou

    2013-03-01

    The 21st century is the information era. IC (Integrated Circuit) is the basis of the modern information industry. The security vulnerability or back door of IC is directly related to the entire information system security. From the perspective of information security, security vulnerability of chip is led out through the practical examples and then the importance of security vulnerability of chip is emphasized. By comparing the security vulnerability of chip with the software virus, the characteristics of the chip vulnerabilities are summed up. Moreover, this paper describes the security vulnerability models of different control logic chips, combinational and sequential logic chips models. Finally it puts forward two kinds of detecting methods of security vulnerability of chip against the two models.

  8. Experiment list: SRX122556 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available chip antibody=Stat1 || treatment=LPS || time=120 min || chip antibody manufacturer 1=Santa Cruz || chip anti...body catalog number 1=sc-346 || chip antibody manufacturer 2=Bethyl || chip antibody catalog number 2=A302-7

  9. Experiment list: SRX122465 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available 6 || chip antibody=Relb || treatment=LPS || time=120 min || chip antibody manufacturer 1=Bethyl || chip anti...body catalog number 1=A302-183A || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2

  10. Experiment list: SRX122555 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available chip antibody=Stat1 || treatment=LPS || time=120 min || chip antibody manufacturer 1=Santa Cruz || chip anti...body catalog number 1=sc-346 || chip antibody manufacturer 2=Bethyl || chip antibody catalog number 2=A302-7

  11. Single cell electroporation on chip

    NARCIS (Netherlands)

    Valero, Ana

    2006-01-01

    In this thesis the results of the development of microfluidic cell trap devices for single cell electroporation are described, which are to be used for gene transfection. The performance of two types of Lab-on-a-Chip trapping devices was tested using beads and cells, whereas the functionality for si

  12. Reconfigurable Networks-on-Chip

    CERN Document Server

    Chen, Sao-Jie; Tsai, Wen-Chung; Hu, Yu-Hen

    2012-01-01

    This book provides a comprehensive survey of recent progress in the design and implementation of Networks-on-Chip. It addresses a wide spectrum of on-chip communication problems, ranging from physical, network, to application layers. Specific topics that are explored in detail include packet routing, resource arbitration, error control/correction, application mapping, and communication scheduling. Additionally, a novel bi-directional communication channel NoC (BiNoC) architecture is described, with detailed explanation.   Written for practicing engineers in need of practical knowledge about the design and implementation of networks-on-chip; Includes tutorial-like details to introduce readers to a diverse range of NoC designs, as well as in-depth analysis for designers with NoC experience to explore advanced issues; Describes a variety of on-chip communication architectures, including a novel bi-directional communication channel NoC.     From the Foreword: Overall this book shows important advances over the...

  13. Ultracold atoms on atom chips

    DEFF Research Database (Denmark)

    Krüger, Peter; Hofferberth, S.; Haller, E.

    2005-01-01

    Miniaturized potentials near the surface of atom chips can be used as flexible and versatile tools for the manipulation of ultracold atoms on a microscale. The full scope of possibilities is only accessible if atom-surface distances can be reduced to microns. We discuss experiments in this regime...

  14. FERMI multi-chip module

    CERN Multimedia

    This FERMI multi-chip module contains five million transistors. 25 000 of these modules will handle the flood of information through parts of the ATLAS and CMS detectors at the LHC. To select interesting events for recording, crucial decisions are taken before the data leaves the detector. FERMI modules are being developed at CERN in partnership with European industry.

  15. Silicon ball grid array chip carrier

    Science.gov (United States)

    Palmer, David W.; Gassman, Richard A.; Chu, Dahwey

    2000-01-01

    A ball-grid-array integrated circuit (IC) chip carrier formed from a silicon substrate is disclosed. The silicon ball-grid-array chip carrier is of particular use with ICs having peripheral bond pads which can be reconfigured to a ball-grid-array. The use of a semiconductor substrate such as silicon for forming the ball-grid-array chip carrier allows the chip carrier to be fabricated on an IC process line with, at least in part, standard IC processes. Additionally, the silicon chip carrier can include components such as transistors, resistors, capacitors, inductors and sensors to form a "smart" chip carrier which can provide added functionality and testability to one or more ICs mounted on the chip carrier. Types of functionality that can be provided on the "smart" chip carrier include boundary-scan cells, built-in test structures, signal conditioning circuitry, power conditioning circuitry, and a reconfiguration capability. The "smart" chip carrier can also be used to form specialized or application-specific ICs (ASICs) from conventional ICs. Types of sensors that can be included on the silicon ball-grid-array chip carrier include temperature sensors, pressure sensors, stress sensors, inertia or acceleration sensors, and/or chemical sensors. These sensors can be fabricated by IC processes and can include microelectromechanical (MEM) devices.

  16. Mycoflora and nutrient analysis of sundried cassava chips (Manihot ...

    African Journals Online (AJOL)

    SARAH

    2014-08-22

    Aug 22, 2014 ... cassava chips (Manihot esculenta) during storage. 7411. Mycoflora and .... of the stored dried cassava chips were scrapped and plated aseptically on potato ..... storage of plantain chips and the health implications. Journal of ...

  17. Infrared vertically-illuminated photodiode for chip alignment feedback

    CERN Document Server

    Alloatti, Luca

    2016-01-01

    We report on vertically-illuminated photodiodes fabricated in the GlobalFoundries 45nm 12SOI node and on a packaging concept for optically-interconnected chips. The photodiodes are responsive at 1180 nm, a wavelength currently used in chip-to-chip communications. They have further a wide field-of-view which enables chip-to-board positional feedback in chip-board assemblies. Monolithic integration enables on-chip processing of the positional data.

  18. Detecting Neutral Atoms on an Atom Chip

    OpenAIRE

    Wilzbach, M.; Haase, A.; Schwarz, M; Heine, D.; Wicker, K.; Liu, X; Brenner, K. -H.; Groth, S.; Fernholz, Th.; Hessmo, B.; Schmiedmayer, J.

    2006-01-01

    Detecting single atoms (qubits) is a key requirement for implementing quantum information processing on an atom chip. The detector should ideally be integrated on the chip. Here we present and compare different methods capable of detecting neutral atoms on an atom chip. After a short introduction to fluorescence and absorption detection we discuss cavity enhanced detection of single atoms. In particular we concentrate on optical fiber based detectors such as fiber cavities and tapered fiber d...

  19. Wax-bonding 3D microfluidic chips

    KAUST Repository

    Gong, Xiuqing

    2013-10-10

    We report a simple, low-cost and detachable microfluidic chip incorporating easily accessible paper, glass slides or other polymer films as the chip materials along with adhesive wax as the recycling bonding material. We use a laser to cut through the paper or film to form patterns and then sandwich the paper and film between glass sheets or polymer membranes . The hot-melt adhesive wax can realize bridge bonding between various materials, for example, paper, polymethylmethacrylate (PMMA) film, glass sheets, or metal plate. The bonding process is reversible and the wax is reusable through a melting and cooling process. With this process, a three-dimensional (3D) microfluidic chip is achievable by vacuating and venting the chip in a hot-water bath. To study the biocompatibility and applicability of the wax-based microfluidic chip, we tested the PCR compatibility with the chip materials first. Then we applied the wax-paper based microfluidic chip to HeLa cell electroporation (EP ). Subsequently, a prototype of a 5-layer 3D chip was fabricated by multilayer wax bonding. To check the sealing ability and the durability of the chip, green fluorescence protein (GFP) recombinant Escherichia coli (E. coli) bacteria were cultured, with which the chemotaxis of E. coli was studied in order to determine the influence of antibiotic ciprofloxacin concentration on the E. coli migration.

  20. Photonic network-on-chip design

    CERN Document Server

    Bergman, Keren; Biberman, Aleksandr; Chan, Johnnie; Hendry, Gilbert

    2013-01-01

    This book provides a comprehensive synthesis of the theory and practice of photonic devices for networks-on-chip. It outlines the issues in designing photonic network-on-chip architectures for future many-core high performance chip multiprocessors. The discussion is built from the bottom up: starting with the design and implementation of key photonic devices and building blocks, reviewing networking and network-on-chip theory and existing research, and finishing with describing various architectures, their characteristics, and the impact they will have on a computing system. After acquainting

  1. Fermilab silicon strip readout chip for BTev

    Energy Technology Data Exchange (ETDEWEB)

    Yarema, Raymond; Hoff, Jim; Mekkaoui, Abderrezak; Manghisoni, Massimo; Re, Valerio; Angeleri, Valentina; Manfredi, Pier Francesco; Ratti, Lodovico; Speziali, Valeria; /Fermilab /Bergamo U. /INFN, Pavia /Pavia U.

    2005-05-01

    A chip has been developed for reading out the silicon strip detectors in the new BTeV colliding beam experiment at Fermilab. The chip has been designed in a 0.25 {micro}m CMOS technology for high radiation tolerance. Numerous programmable features have been added to the chip, such as setup for operation at different beam crossing intervals. A full size chip has been fabricated and successfully tested. The design philosophy, circuit features, and test results are presented in this paper.

  2. On-Chip Detection of Cellular Activity

    Science.gov (United States)

    Almog, R.; Daniel, R.; Vernick, S.; Ron, A.; Ben-Yoav, H.; Shacham-Diamand, Y.

    The use of on-chip cellular activity monitoring for biological/chemical sensing is promising for environmental, medical and pharmaceutical applications. The miniaturization revolution in microelectronics is harnessed to provide on-chip detection of cellular activity, opening new horizons for miniature, fast, low cost and portable screening and monitoring devices. In this chapter we survey different on-chip cellular activity detection technologies based on electrochemical, bio-impedance and optical detection. Both prokaryotic and eukaryotic cell-on-chip technologies are mentioned and reviewed.

  3. On-chip plasmonic spectrometer.

    Science.gov (United States)

    Tsur, Yuval; Arie, Ady

    2016-08-01

    We report a numerical and experimental study of an on-chip optical spectrometer, utilizing propagating surface plasmon polaritons in the telecom spectral range. The device is based on two holographic gratings, one for coupling, and the other for decoupling free-space radiation with the surface plasmons. This 800 μm×100 μm on-chip spectrometer resolves 17 channels spectrally separated by 3.1 nm, spanning a freely tunable spectral window, and is based on standard lithography fabrication technology. We propose two potential applications for this new device; the first employs the holographic control over the amplitude and phase of the input spectrum, for intrinsically filtering unwanted frequencies, like pump radiation in Raman spectroscopy. The second prospect utilizes the unique plasmonic field enhancement at the metal-dielectric boundary for the spectral analysis of very small samples (e.g., Mie scatterers) placed between the two gratings.

  4. On chip shapeable optical tweezers.

    Science.gov (United States)

    Renaut, C; Cluzel, B; Dellinger, J; Lalouat, L; Picard, E; Peyrade, D; Hadji, E; de Fornel, F

    2013-01-01

    Particles manipulation with optical forces is known as optical tweezing. While tweezing in free space with laser beams was established in the 1980s, integrating the optical tweezers on a chip is a challenging task. Recent experiments with plasmonic nanoantennas, microring resonators, and photonic crystal nanocavities have demonstrated optical trapping. However, the optical field of a tweezer made of a single microscopic resonator cannot be shaped. So far, this prevents from optically driven micromanipulations. Here we propose an alternative approach where the shape of the optical trap can be tuned by the wavelength in coupled nanobeam cavities. Using these shapeable tweezers, we present micromanipulation of polystyrene microspheres trapped on a silicon chip. These results show that coupled nanobeam cavities are versatile building blocks for optical near-field engineering. They open the way to much complex integrated tweezers using networks of coupled nanobeam cavities for particles or bio-objects manipulation at a larger scale.

  5. Mimosa 32-ter Chip Characterisation

    CERN Document Server

    Behera, Arabinda

    2013-01-01

    The Inner Tracking System (ITS) is a very important part of the ALICE detector. Present ITS is made up of 6 coaxial layers of silicon detectors (2 SPD, 2 SDD and 2 SSD). This system has a lot of limitations. Its tracking efficiency and resolution is low. Its readout rate is also very slow. Its not possible to study charm and beauty baryons and mesons with this system. So the upcoming ITS Upgrade plan will try to overcome these shortcomings. A very crucial part in this plan is to replace the existing hybrid sensors by new and advanced Monolithic Active Pixel Sensors(MAPS). In MAPS the sensor and the electronics are embedded in the same chip. The MAPS will reduce the material budget, increase the readout rate and enhance the tracking efficiency and momentum resolution. In this report I will present the results for the Characterisation of MIMOSA 32-ter chip, which is a MAPS. My main aim is to calculate the Charge Collection Efficiency of different sectors of the chip and compare between them. And most importa...

  6. Micro-PIV技术--粒子图像测速技术的新进展%MICRO-PIV: A NEW DEVELOPMENT OF PARTICLE IMAGE VELOCIMETRY

    Institute of Scientific and Technical Information of China (English)

    王昊利; 王元

    2005-01-01

    Micro-PIV是近年来发展起来的一种微尺度流动测速技术.它是传统PIV测量与光学显微技术相结合的一种整场、瞬态、定量测量方法,其基本测速原理与传统PIV相同,但在示踪粒子选择、图像获取和处理等方面两者存在较大差别.Micro-PIV突破了传统微尺度流体力学测量手段的局限性,使得对微尺度流动元件的研究从过去只能给出流量、阻力特性等有限信息逐步转向对全流场内流结构的直接测量上,并且达到了相当高的分辨率和测量精度.本文对近几年Micro-PIV技术发展状况进行了总结和分析,论述了Micro-PIV技术与传统PIV的主要区别以及具体的处理技术,反映了其在科学与工程中的应用,并对此项技术的发展作了展望.

  7. New Three-Dimensional Integration Technology Using Chip-to-Wafer Bonding to Achieve Ultimate Super-Chip Integration

    Science.gov (United States)

    Fukushima, Takafumi; Yamada, Yusuke; Kikuchi, Hirokazu; Koyanagi, Mitsumasa

    2006-04-01

    A new three-dimensional (3D) integration technology using the chip-to-wafer bonding technique provides the ultimate super-chip integration in which various kinds of chip of different sizes can be vertically stacked and electrically connected through a number of vertical interconnections. We have investigated several key technologies of vertical interconnection formation, chip alignment, chip-to-wafer bonding, adhesive injection, and chip thinning to vertically stack known good dies (KGDs) into 3D LSI chips. By using these key technologies, successful fabrication of 3D LSI test chips with vertical interconnections consisting of In-Au microbumps and buried interconnections filled with polycrystalline silicon (poly-Si) was demonstrated. The test chips was composed of three kinds of very thin chip of 5, 6, and 7 mm2 and ranging in thickness from 30 to 90 μm. Each chip is tightly bonded using a low-viscosity epoxy adhesive as a dielectric material.

  8. Teaching Quality Control with Chocolate Chip Cookies

    Science.gov (United States)

    Baker, Ardith

    2014-01-01

    Chocolate chip cookies are used to illustrate the importance and effectiveness of control charts in Statistical Process Control. By counting the number of chocolate chips, creating the spreadsheet, calculating the control limits and graphing the control charts, the student becomes actively engaged in the learning process. In addition, examining…

  9. Micromachined glass chips for ion analysis

    NARCIS (Netherlands)

    Gardeniers, Han; Mulder, Micha; Lüttge, Regina; Berg, van den Albert

    2002-01-01

    This article describes recent developments at Micronit Microfluidics B.V. and MESA+ in the field of "Lab-on-a-chip" systems for ion analysis. Glass chips with typical micromachined channel geometries for capillary electrophoresis and integrated conductivity detection were developed, with which separ

  10. Lab-on a-Chip

    Science.gov (United States)

    2003-01-01

    Helen Cole, the project manager for the Lab-on-a-Chip Applications Development program, and Lisa Monaco, the project scientist for the program, insert a lab on a chip into the Caliper 42 which is specialized equipment that controls processes on commercial chips to support development of lab-on-a-chip applications. The system has special microscopes and imaging systems, so scientists can process and study different types of fluid, chemical, and medical tests conducted on chips. For example, researchers have examined fluorescent bacteria as it flows through the chips' fluid channels or microfluidic capillaries. Researchers at NASA's Marshall Space Flight Center (MSFC) in Huntsville, Alabama, have been studying how the lab-on-a-chip technology can be used for microbial detection, water quality monitoring, and detecting biosignatures of past or present life on Mars. The Marshall Center team is also collaborating with scientists at other NASA centers and at universities to develop custom chip designs for not only space applications, but for many Earth applications, such as for detecting deadly microbes in heating and air systems. (NASA/MSFC/D.Stoffer)

  11. Superconducting chip receivers for imaging application

    NARCIS (Netherlands)

    Shitov, SV; Koshelets, VP; Ermakov, AB; Filippenko, LV; Baryshev, AM; Luinge, W; Gao, [No Value

    1999-01-01

    Experimental details of a unique superconducting imaging array receiver are discussed. Each pixel contains an internally pumped receiver chip mounted on the back of the elliptical microwave lens. Each chip comprises a quasi-optical SIS mixer integrated with a superconducting flux-flow oscillator (FF

  12. Multimedia-Based Chip Design Education.

    Science.gov (United States)

    Catalkaya, Tamer; Golze, Ulrich

    This paper focuses on multimedia computer-based training programs on chip design. Their development must be fast and economical, in order to be affordable by technical university institutions. The self-produced teaching program Illusion, which demonstrates a monitor controller as an example of a small but complete chip design, was implemented to…

  13. Simple photolithographic rapid prototyping of microfluidic chips

    DEFF Research Database (Denmark)

    Kunstmann-Olsen, Casper; Hoyland, James; Rubahn, Horst-Günter

    2012-01-01

    Vi præsenterer en simpel metode til at producere støbeforme til støbning af PDMS mikrofluide chips vha. fotolitografi, med 35mm fotonegativer som masker. Vi demonstrer metodens muligheder og begrænsninger. Vi har optimeret processen til at fremstille planare lab-on-a-chip strukturer med meget høj...

  14. Microluminometer chip and method to measure bioluminescence

    Science.gov (United States)

    Simpson, Michael L [Knoxville, TN; Paulus, Michael J [Knoxville, TN; Sayler, Gary S [Blaine, TN; Applegate, Bruce M [West Lafayette, IN; Ripp, Steven A [Knoxville, TN

    2008-05-13

    An integrated microluminometer includes an integrated circuit chip having at least one n-well/p-substrate junction photodetector for converting light received into a photocurrent, and a detector on the chip for processing the photocurrent. A distributed electrode configuration including a plurality of spaced apart electrodes disposed on an active region of the photodetector is preferably used to raise efficiency.

  15. Least cost supply strategies for wood chips

    DEFF Research Database (Denmark)

    Möller, Bernd

    The abstract presents a study based on a geographical information system, which produce  cost-supply curves by location for forest woods chips in Denmark.......The abstract presents a study based on a geographical information system, which produce  cost-supply curves by location for forest woods chips in Denmark....

  16. Microluminometer chip and method to measure bioluminescence

    Energy Technology Data Exchange (ETDEWEB)

    Simpson, Michael L [Knoxville, TN; Paulus, Michael J [Knoxville, TN; Sayler, Gary S [Blaine, TN; Applegate, Bruce M [West Lafayette, IN; Ripp, Steven A [Knoxville, TN

    2008-05-13

    An integrated microluminometer includes an integrated circuit chip having at least one n-well/p-substrate junction photodetector for converting light received into a photocurrent, and a detector on the chip for processing the photocurrent. A distributed electrode configuration including a plurality of spaced apart electrodes disposed on an active region of the photodetector is preferably used to raise efficiency.

  17. Simple photolithographic rapid prototyping of microfluidic chips

    DEFF Research Database (Denmark)

    Kunstmann-Olsen, Casper; Hoyland, James; Rubahn, Horst-Günter

    2012-01-01

    Vi præsenterer en simpel metode til at producere støbeforme til støbning af PDMS mikrofluide chips vha. fotolitografi, med 35mm fotonegativer som masker. Vi demonstrer metodens muligheder og begrænsninger. Vi har optimeret processen til at fremstille planare lab-on-a-chip strukturer med meget høj...

  18. Least cost supply strategies for wood chips

    DEFF Research Database (Denmark)

    Möller, Bernd

    The abstract presents a study based on a geographical information system, which produce  cost-supply curves by location for forest woods chips in Denmark.......The abstract presents a study based on a geographical information system, which produce  cost-supply curves by location for forest woods chips in Denmark....

  19. Teaching Quality Control with Chocolate Chip Cookies

    Science.gov (United States)

    Baker, Ardith

    2014-01-01

    Chocolate chip cookies are used to illustrate the importance and effectiveness of control charts in Statistical Process Control. By counting the number of chocolate chips, creating the spreadsheet, calculating the control limits and graphing the control charts, the student becomes actively engaged in the learning process. In addition, examining…

  20. Assembly, chip and method of operating

    NARCIS (Netherlands)

    Reefman, D.; Roozeboom, F.; Klootwijk, J.H.

    2012-01-01

    The chip comprises a network of trench capacitors and an inductor, wherein the trench capacitors are coupled in parallel with a pattern of interconnects that is designed so as to limit generation of eddy current induced by the inductor in the interconnects. This allows the use of the chip as a porti

  1. Asynchronous design of Networks-on-Chip

    DEFF Research Database (Denmark)

    Sparsø, Jens

    2007-01-01

    The Network-on-chip concept has evolved as a solution to a broad range of problems related to the design of complex systems-on-chip (SoC) with tenths or hundreds of (heterogeneous) IP-cores. The paper introduces the NoC concept, identifies a range of possible timing organizations (globally...

  2. Glass microfabricated nebulizer chip for mass spectrometry.

    Science.gov (United States)

    Saarela, Ville; Haapala, Markus; Kostiainen, Risto; Kotiaho, Tapio; Franssila, Sami

    2007-05-01

    A microfluidic nebulizer chip for mass spectrometry is presented. It is an all-glass device which consists of fusion bonded Pyrex wafers with embedded flow channels and a nozzle at the chip edge. A platinum heater is located on the wafer backside. Fabrication of the chip is detailed, especially glass deep etching, wafer bonding, and metal patterning. Various process combinations of bonding and metallization have been considered (anodic bonding vs. fusion bonding; heater inside/outside channel; metallization before/after bonding; platinum lift-off vs. etching). The chip vaporizes the liquid sample (0.1-10 microL min(-1)) and mixes it with a nebulizer gas (ca. 100 sccm N2). Operating temperatures can go up to 500 degrees C ensuring efficient vaporization. Thermal insulation of the glass ensures low temperatures at the far end of the chip, enabling easy interconnections.

  3. Research of Dielectric Breakdown Microfluidic Sampling Chip

    Directory of Open Access Journals (Sweden)

    Feng Jiang

    2013-01-01

    Full Text Available Microfluidic chip is mainly driven electrically by external electrode and array electrode, but there are certain disadvantages in both of ways, which affect the promotion and application of microfluidic technology. This paper discusses a scheme that uses the conductive solution in a microchannel made by PDMS, replacing electrodes and the way of dielectric breakdown to achieve microfluidic chip driver. It could reduce the driving voltage and simplify the chip production process. To prove the feasibility of this method, we produced a microfluidic chip used in PDMS material with the lithography technology and experimented it. The results showed that using the dielectric breakdown to achieve microfluidic chip driver is feasible, and it has certain application prospect.

  4. Experiment list: SRX122474 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available p antibody=Runx1 || treatment=LPS || time=60 min || chip antibody manufacturer 1=Abcam || chip antibody cata...log number 1=ab61753 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-8564 ht

  5. Experiment list: SRX122562 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available antibody=Stat1 || treatment=LPS || time=30 min || chip antibody manufacturer 1=Santa Cruz || chip antibody ...catalog number 1=sc-346 || chip antibody manufacturer 2=Bethyl || chip antibody catalog number 2=A302-753A h

  6. Experiment list: SRX214083 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ufacturer 1=Santa Cruz || chip antibody 2=V5 || chip antibody manufacturer...tage=Undifferentiated || treatment=Overexpress Sox17EK-V5 tagged || cell line=KH2 || chip antibody 1=Pou5f1/Oct4 || chip antibody man

  7. Experiment list: SRX760380 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available lization=6-8 || chip antibody=ELAV || chip antibody vendor=Developmental Studies Hybridoma Bank (DSHB) || chip catalog... number=mouse anti-ELAV-9F8A9 || chip catalog number=rat anti-ELAV-7E8A

  8. Experiment list: SRX760382 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available tilization=10-12 || chip antibody=ELAV || chip antibody vendor=Developmental Studies Hybridoma Bank (DSHB) || chip catalog... number=mouse anti-ELAV-9F8A9 || chip catalog number=rat anti-ELAV-

  9. Experiment list: SRX122560 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ip antibody=Stat1 || treatment=LPS || time=120 min || chip antibody manufacturer 1=Santa Cruz || chip antibody catalog... number 1=sc-346 || chip antibody manufacturer 2=Bethyl || chip antibody catalog number 2=A302-753

  10. Experiment list: SRX122470 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available p antibody=Rela || treatment=LPS || time=30 min || chip antibody manufacturer 1=Bethyl || chip antibody catalog... number 1=A301-824A || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-372 h

  11. Experiment list: SRX760381 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available lization=6-8 || chip antibody=ELAV || chip antibody vendor=Developmental Studies Hybridoma Bank (DSHB) || chip catalog... number=mouse anti-ELAV-9F8A9 || chip catalog number=rat anti-ELAV-7E8A

  12. Experiment list: SRX760383 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available tilization=10-12 || chip antibody=ELAV || chip antibody vendor=Developmental Studies Hybridoma Bank (DSHB) || chip catalog... number=mouse anti-ELAV-9F8A9 || chip catalog number=rat anti-ELAV-

  13. Experiment list: SRX122492 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ntibody=Atf3 || treatment=LPS || time=60 min || chip antibody manufacturer 1=Santa Cruz || chip antibody cat...alog number 1=sc-188 || chip antibody manufacturer 2=Abcam || chip antibody catalog number 2=ab70005-100 htt

  14. Experiment list: SRX122471 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ip antibody=Rela || treatment=LPS || time=60 min || chip antibody manufacturer 1=Bethyl || chip antibody cat...alog number 1=A301-824A || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-372

  15. Experiment list: SRX122493 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available antibody=Atf4 || treatment=LPS || time=120 min || chip antibody manufacturer 1=Abcam || chip antibody catal...og number 1=ab28830-100 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-200

  16. Experiment list: SRX122516 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available antibody=Irf2 || treatment=LPS || time=120 min || chip antibody manufacturer 1=Abcam || chip antibody catalo...g number 1=ab65048 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-498 http:

  17. Experiment list: SRX122484 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ntibody=Atf3 || treatment=LPS || time=0 min || chip antibody manufacturer 1=Santa Cruz || chip antibody cata...log number 1=sc-188 || chip antibody manufacturer 2=Abcam || chip antibody catalog number 2=ab70005-100 http

  18. Experiment list: SRX122554 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ip antibody=Stat1 || treatment=LPS || time=120 min || chip antibody manufacturer 1=Santa Cruz || chip antibo...dy catalog number 1=sc-346 || chip antibody manufacturer 2=Bethyl || chip antibody catalog number 2=A302-753

  19. Experiment list: SRX122488 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available antibody=Atf3 || treatment=LPS || time=120 min || chip antibody manufacturer 1=Santa Cruz || chip antibody c...atalog number 1=sc-188 || chip antibody manufacturer 2=Abcam || chip antibody catalog number 2=ab70005-100 h

  20. Experiment list: SRX214078 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available =Undifferentiated || treatment=Overexpress Sox2-V5 tagged || cell line=KH2 || chip antibody 1=Pou5f1/Oct4 || chip antibody manufactur...er 1=Santa Cruz || chip antibody 2=V5 || chip antibody manufacture

  1. Experiment list: SRX122515 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available tibody=Irf2 || treatment=LPS || time=0 min || chip antibody manufacturer 1=Abcam || chip antibody catalog nu...mber 1=ab65048 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-498 http://db

  2. Experiment list: SRX122489 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ntibody=Atf3 || treatment=LPS || time=30 min || chip antibody manufacturer 1=Santa Cruz || chip antibody cat...alog number 1=sc-188 || chip antibody manufacturer 2=Abcam || chip antibody catalog number 2=ab70005-100 htt

  3. Experiment list: SRX122469 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available hip antibody=Rela || treatment=LPS || time=120 min || chip antibody manufacturer 1=Bethyl || chip antibody c...atalog number 1=A301-824A || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-37

  4. Experiment list: SRX122563 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available antibody=Stat1 || treatment=LPS || time=60 min || chip antibody manufacturer 1=Santa Cruz || chip antibody ...catalog number 1=sc-346 || chip antibody manufacturer 2=Bethyl || chip antibody catalog number 2=A302-753A h

  5. Experiment list: SRX122487 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available antibody=Atf3 || treatment=LPS || time=120 min || chip antibody manufacturer 1=Santa Cruz || chip antibody c...atalog number 1=sc-188 || chip antibody manufacturer 2=Abcam || chip antibody catalog number 2=ab70005-100 h

  6. Experiment list: SRX122546 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available p antibody=Stat1 || treatment=LPS || time=0 min || chip antibody manufacturer 1=Santa Cruz || chip antibody ...catalog number 1=sc-346 || chip antibody manufacturer 2=Bethyl || chip antibody catalog number 2=A302-753A h

  7. Experiment list: SRX214082 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available facturer 1=Santa Cruz || chip antibody 2=V5 || chip antibody manufacture...age=Undifferentiated || treatment=Overexpress Sox17EK-V5 tagged || cell line=KH2 || chip antibody 1=Pou5f1/Oct4 || chip antibody manu

  8. Experiment list: SRX122548 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ip antibody=Stat1 || treatment=LPS || time=0 min || chip antibody manufacturer 1=Santa Cruz || chip antibody... catalog number 1=sc-346 || chip antibody manufacturer 2=Bethyl || chip antibody catalog number 2=A302-753A

  9. Experiment list: SRX122510 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available antibody=Egr1 || treatment=LPS || time=0 min || chip antibody manufacturer 1=Abcam || chip antibody catalog... number 1=ab54966-100 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-110 ht

  10. Experiment list: SRX122573 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available antibody=Stat2 || treatment=LPS || time=60 min || chip antibody manufacturer 1=Abcam || chip antibody catal...og number 1=ab53149 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-839 http

  11. Experiment list: SRX122495 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ntibody=Rel || treatment=LPS || time=0 min || chip antibody manufacturer 1=Santa Cruz || chip antibody catal...og number 1=sc-71 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-70 http://

  12. Experiment list: SRX122468 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available antibody=Rela || treatment=LPS || time=0 min || chip antibody manufacturer 1=Bethyl || chip antibody catalo...g number 1=A301-824A || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-372 htt

  13. Experiment list: SRX214084 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available turer 1=Santa Cruz || chip antibody 2=V5 || chip antibody manufacture...ge=Undifferentiated || treatment=Overexpress Sox17-V5 tagged || cell line=KH2 || chip antibody 1=Pou5f1/Oct4 || chip antibody manufac

  14. Experiment list: SRX122559 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ip antibody=Stat1 || treatment=LPS || time=120 min || chip antibody manufacturer 1=Santa Cruz || chip antibo...dy catalog number 1=sc-346 || chip antibody manufacturer 2=Bethyl || chip antibody catalog number 2=A302-753

  15. Experiment list: SRX122491 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ntibody=Atf3 || treatment=LPS || time=60 min || chip antibody manufacturer 1=Santa Cruz || chip antibody cat...alog number 1=sc-188 || chip antibody manufacturer 2=Abcam || chip antibody catalog number 2=ab70005-100 htt

  16. Experiment list: SRX214079 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Undifferentiated || treatment=Overexpress Sox2-V5 tagged || cell line=KH2 || chip antibody 1=Pou5f1/Oct4 || chip antibody manufacture...r 1=Santa Cruz || chip antibody 2=V5 || chip antibody manufacture

  17. Experiment list: SRX122511 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ip antibody=Egr1 || treatment=LPS || time=120 min || chip antibody manufacturer 1=Abcam || chip antibody cat...alog number 1=ab54966-100 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-11

  18. Experiment list: SRX122547 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available antibody=Stat1 || treatment=LPS || time=0 min || chip antibody manufacturer 1=Santa Cruz || chip antibody c...atalog number 1=sc-346 || chip antibody manufacturer 2=Bethyl || chip antibody catalog number 2=A302-753A ht

  19. Experiment list: SRX122571 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available antibody=Stat2 || treatment=LPS || time=30 min || chip antibody manufacturer 1=Abcam || chip antibody catal...og number 1=ab53149 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-839 http

  20. Experiment list: SRX122550 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available antibody=Stat1 || treatment=LPS || time=0 min || chip antibody manufacturer 1=Santa Cruz || chip antibody ca...talog number 1=sc-346 || chip antibody manufacturer 2=Bethyl || chip antibody catalog number 2=A302-753A htt

  1. Experiment list: SRX122483 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ntibody=Atf3 || treatment=LPS || time=0 min || chip antibody manufacturer 1=Santa Cruz || chip antibody cata...log number 1=sc-188 || chip antibody manufacturer 2=Abcam || chip antibody catalog number 2=ab70005-100 http

  2. Experiment list: SRX122564 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available antibody=Stat1 || treatment=LPS || time=60 min || chip antibody manufacturer 1=Santa Cruz || chip antibody ...catalog number 1=sc-346 || chip antibody manufacturer 2=Bethyl || chip antibody catalog number 2=A302-753A h

  3. Experiment list: SRX122518 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available antibody=Irf2 || treatment=LPS || time=120 min || chip antibody manufacturer 1=Abcam || chip antibody catalo...g number 1=ab65048 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-498 http:

  4. Experiment list: SRX122512 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available p antibody=Egr1 || treatment=LPS || time=30 min || chip antibody manufacturer 1=Abcam || chip antibody catal...og number 1=ab54966-100 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-110

  5. Experiment list: SRX122544 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available antibody=Stat1 || treatment=LPS || time=0 min || chip antibody manufacturer 1=Santa Cruz || chip antibody c...atalog number 1=sc-346 || chip antibody manufacturer 2=Bethyl || chip antibody catalog number 2=A302-753A ht

  6. Experiment list: SRX122569 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ip antibody=Stat2 || treatment=LPS || time=120 min || chip antibody manufacturer 1=Abcam || chip antibody ca...talog number 1=ab53149 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-839 h

  7. Experiment list: SRX122494 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available hip antibody=Atf4 || treatment=LPS || time=120 min || chip antibody manufacturer 1=Abcam || chip antibody ca...talog number 1=ab28830-100 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-2

  8. Experiment list: SRX122408 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available p antibody=Irf1 || treatment=LPS || time=30 min || chip antibody manufacturer 1=Abcam || chip antibody catal...og number 1=ab52520 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-640 http

  9. Experiment list: SRX122552 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ip antibody=Stat1 || treatment=LPS || time=120 min || chip antibody manufacturer 1=Santa Cruz || chip antibo...dy catalog number 1=sc-346 || chip antibody manufacturer 2=Bethyl || chip antibody catalog number 2=A302-753

  10. Experiment list: SRX214068 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available inoic acid || cell line=F9 || chip antibody 1=Pou5f1/Oct4 || chip antibody manufacturer 1=Santa Cruz || chip... antibody 2=none || chip antibody manufacturer 2=none http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/eachDat

  11. Experiment list: SRX122464 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available antibody=Relb || treatment=LPS || time=0 min || chip antibody manufacturer 1=Bethyl || chip antibody catalo...g number 1=A302-183A || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-226 htt

  12. Experiment list: SRX122466 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available p antibody=Relb || treatment=LPS || time=30 min || chip antibody manufacturer 1=Bethyl || chip antibody cata...log number 1=A302-183A || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-226 h

  13. Experiment list: SRX122545 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available antibody=Stat1 || treatment=LPS || time=0 min || chip antibody manufacturer 1=Santa Cruz || chip antibody c...atalog number 1=sc-346 || chip antibody manufacturer 2=Bethyl || chip antibody catalog number 2=A302-753A ht

  14. Experiment list: SRX122553 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ip antibody=Stat1 || treatment=LPS || time=120 min || chip antibody manufacturer 1=Santa Cruz || chip antibo...dy catalog number 1=sc-346 || chip antibody manufacturer 2=Bethyl || chip antibody catalog number 2=A302-753

  15. Experiment list: SRX122549 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ip antibody=Stat1 || treatment=LPS || time=0 min || chip antibody manufacturer 1=Santa Cruz || chip antibody... catalog number 1=sc-346 || chip antibody manufacturer 2=Bethyl || chip antibody catalog number 2=A302-753A

  16. Experiment list: SRX122467 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available p antibody=Relb || treatment=LPS || time=60 min || chip antibody manufacturer 1=Bethyl || chip antibody cata...log number 1=A302-183A || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-226 h

  17. Experiment list: SRX122411 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ntibody=Junb || treatment=LPS || time=0 min || chip antibody manufacturer 1=Abcam || chip antibody catalog n...umber 1=ab28838 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-46 http://db

  18. Experiment list: SRX122561 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available antibody=Stat1 || treatment=LPS || time=30 min || chip antibody manufacturer 1=Santa Cruz || chip antibody ...catalog number 1=sc-346 || chip antibody manufacturer 2=Bethyl || chip antibody catalog number 2=A302-753A h

  19. Experiment list: SRX122472 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available antibody=Runx1 || treatment=LPS || time=0 min || chip antibody manufacturer 1=Abcam || chip antibody catalo...g number 1=ab61753 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-8564 http

  20. Experiment list: SRX122473 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ip antibody=Runx1 || treatment=LPS || time=120 min || chip antibody manufacturer 1=Abcam || chip antibody ca...talog number 1=ab61753 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-8564

  1. Experiment list: SRX122572 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available antibody=Stat2 || treatment=LPS || time=30 min || chip antibody manufacturer 1=Abcam || chip antibody catal...og number 1=ab53149 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-839 http

  2. Experiment list: SRX214076 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ferentiated || treatment=Overexpress Sox17-V5 tagged || cell line=KH2 || chip antibody 1=Sox17 || chip antibody manufacture...r 1=R&D || chip antibody 2=V5 || chip antibody manufacturer 2=Invi

  3. Experiment list: SRX214081 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available cturer 1=Santa Cruz || chip antibody 2=V5 || chip antibody manufacture...ge=Undifferentiated || treatment=Overexpress Sox2KE-V5 tagged || cell line=KH2 || chip antibody 1=Pou5f1/Oct4 || chip antibody manufa

  4. Experiment list: SRX122407 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ip antibody=Irf1 || treatment=LPS || time=120 min || chip antibody manufacturer 1=Abcam || chip antibody cat...alog number 1=ab52520 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-640 ht

  5. Experiment list: SRX122410 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ntibody=Junb || treatment=LPS || time=0 min || chip antibody manufacturer 1=Abcam || chip antibody catalog n...umber 1=ab28838 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-46 http://db

  6. Experiment list: SRX122498 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available antibody=Rel || treatment=LPS || time=60 min || chip antibody manufacturer 1=Santa Cruz || chip antibody cat...alog number 1=sc-71 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-70 http:

  7. Experiment list: SRX122517 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available antibody=Irf2 || treatment=LPS || time=120 min || chip antibody manufacturer 1=Abcam || chip antibody catalo...g number 1=ab65048 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-498 http:

  8. Experiment list: SRX122567 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available p antibody=Stat2 || treatment=LPS || time=120 min || chip antibody manufacturer 1=Abcam || chip antibody cat...alog number 1=ab53149 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-839 ht

  9. Experiment list: SRX186172 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available 1=YY1 || chip antibody manufacturer 1=Abcam || chip antibody 2=YY1 || chip antibody manufacturer 2=Santa Cru...ip-Seq; Mus musculus; ChIP-Seq source_name=Rag1 -/- pro-B cells || chip antibody

  10. Experiment list: SRX122486 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available antibody=Atf3 || treatment=LPS || time=120 min || chip antibody manufacturer 1=Santa Cruz || chip antibody c...atalog number 1=sc-188 || chip antibody manufacturer 2=Abcam || chip antibody catalog number 2=ab70005-100 h

  11. Experiment list: SRX122497 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available antibody=Rel || treatment=LPS || time=30 min || chip antibody manufacturer 1=Santa Cruz || chip antibody cat...alog number 1=sc-71 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-70 http:

  12. Experiment list: SRX122490 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ntibody=Atf3 || treatment=LPS || time=30 min || chip antibody manufacturer 1=Santa Cruz || chip antibody cat...alog number 1=sc-188 || chip antibody manufacturer 2=Abcam || chip antibody catalog number 2=ab70005-100 htt

  13. Experiment list: SRX122558 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available hip antibody=Stat1 || treatment=LPS || time=120 min || chip antibody manufacturer 1=Santa Cruz || chip antib...ody catalog number 1=sc-346 || chip antibody manufacturer 2=Bethyl || chip antibody catalog number 2=A302-75

  14. Experiment list: SRX214080 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available cturer 1=Santa Cruz || chip antibody 2=V5 || chip antibody manufacture...ge=Undifferentiated || treatment=Overexpress Sox2KE-V5 tagged || cell line=KH2 || chip antibody 1=Pou5f1/Oct4 || chip antibody manufa

  15. Experiment list: SRX122409 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ip antibody=Irf1 || treatment=LPS || time=60 min || chip antibody manufacturer 1=Abcam || chip antibody cata...log number 1=ab52520 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-640 htt

  16. Experiment list: SRX122551 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available antibody=Stat1 || treatment=LPS || time=0 min || chip antibody manufacturer 1=Santa Cruz || chip antibody ca...talog number 1=sc-346 || chip antibody manufacturer 2=Bethyl || chip antibody catalog number 2=A302-753A htt

  17. Experiment list: SRX122513 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available p antibody=Egr1 || treatment=LPS || time=60 min || chip antibody manufacturer 1=Abcam || chip antibody catal...og number 1=ab54966-100 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-110

  18. Experiment list: SRX122557 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available hip antibody=Stat1 || treatment=LPS || time=120 min || chip antibody manufacturer 1=Santa Cruz || chip antib...ody catalog number 1=sc-346 || chip antibody manufacturer 2=Bethyl || chip antibody catalog number 2=A302-75

  19. Experiment list: SRX122519 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available antibody=Irf2 || treatment=LPS || time=120 min || chip antibody manufacturer 1=Abcam || chip antibody catalo...g number 1=ab65048 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-498 http:

  20. Experiment list: SRX122514 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available tibody=Irf2 || treatment=LPS || time=0 min || chip antibody manufacturer 1=Abcam || chip antibody catalog nu...mber 1=ab65048 || chip antibody manufacturer 2=Santa Cruz || chip antibody catalog number 2=sc-498 http://db

  1. Transcriptional Regulation by CHIP/LDB Complexes

    Science.gov (United States)

    Bronstein, Revital; Levkovitz, Liron; Yosef, Nir; Yanku, Michaela; Ruppin, Eytan; Sharan, Roded; Westphal, Heiner; Oliver, Brian; Segal, Daniel

    2010-01-01

    It is increasingly clear that transcription factors play versatile roles in turning genes “on” or “off” depending on cellular context via the various transcription complexes they form. This poses a major challenge in unraveling combinatorial transcription complex codes. Here we use the powerful genetics of Drosophila combined with microarray and bioinformatics analyses to tackle this challenge. The nuclear adaptor CHIP/LDB is a major developmental regulator capable of forming tissue-specific transcription complexes with various types of transcription factors and cofactors, making it a valuable model to study the intricacies of gene regulation. To date only few CHIP/LDB complexes target genes have been identified, and possible tissue-dependent crosstalk between these complexes has not been rigorously explored. SSDP proteins protect CHIP/LDB complexes from proteasome dependent degradation and are rate-limiting cofactors for these complexes. By using mutations in SSDP, we identified 189 down-stream targets of CHIP/LDB and show that these genes are enriched for the binding sites of APTEROUS (AP) and PANNIER (PNR), two well studied transcription factors associated with CHIP/LDB complexes. We performed extensive genetic screens and identified target genes that genetically interact with components of CHIP/LDB complexes in directing the development of the wings (28 genes) and thoracic bristles (23 genes). Moreover, by in vivo RNAi silencing we uncovered novel roles for two of the target genes, xbp1 and Gs-alpha, in early development of these structures. Taken together, our results suggest that loss of SSDP disrupts the normal balance between the CHIP-AP and the CHIP-PNR transcription complexes, resulting in down-regulation of CHIP-AP target genes and the concomitant up-regulation of CHIP-PNR target genes. Understanding the combinatorial nature of transcription complexes as presented here is crucial to the study of transcription regulation of gene batteries required

  2. Ex Vacuo Atom Chip Bose-Einstein Condensate (BEC)

    CERN Document Server

    Squires, Matthew B; Kasch, Brian; Stickney, James A; Erickson, Christopher J; Crow, Jonathan A R; Carlson, Evan J; Burke, John H

    2016-01-01

    Ex vacuo atom chips, used in conjunction with a custom thin walled vacuum chamber, have enabled the rapid replacement of atom chips for magnetically trapped cold atom experiments. Atoms were trapped in $>2$ kHz magnetic traps created using high power atom chips. The thin walled vacuum chamber allowed the atoms to be trapped $\\lesssim1$ mm from the atom chip conductors which were located outside of the vacuum system. Placing the atom chip outside of the vacuum simplified the electrical connections and improved thermal management. Using a multi-lead Z-wire chip design, a Bose-Einstein condensate was produced with an external atom chip. Vacuum and optical conditions were maintained while replacing the Z-wire chip with a newly designed cross-wire chip. The atom chips were exchanged and an initial magnetic trap was achieved in less than three hours.

  3. 75 FR 447 - In the Matter of Certain Semiconductor Chips With Minimized Chip Package Size and Products...

    Science.gov (United States)

    2010-01-05

    ... Certain Semiconductor Chips With Minimized Chip Package Size and Products Containing Same (III); Notice of... States after importation of certain semiconductor chips with minimized chip package size or products... Semiconductor Corporation of Hsinchu, Taiwan; ProMOS Technologies, Inc. of Hsinchu, Taiwan; Ramaxel...

  4. 75 FR 30046 - Medicaid and CHIP Programs; Meeting of the CHIP Working Group-June 14, 2010

    Science.gov (United States)

    2010-05-28

    ... Administration Medicaid and CHIP Programs; Meeting of the CHIP Working Group-- June 14, 2010 AGENCY: Centers for...-Sponsored Coverage Coordination Working Group ] (referred to as the ``CHIP Working Group''). The CHIP Working Group will meet to address objectives specified under section 311(b)(1)(C) of the...

  5. Self-powered integrated systems-on-chip (energy chip)

    KAUST Repository

    Hussain, Muhammad Mustafa

    2010-04-23

    In today\\'s world, consumer driven technology wants more portable electronic gadgets to be developed, and the next big thing in line is self-powered handheld devices. Therefore to reduce the power consumption as well as to supply sufficient power to run those devices, several critical technical challenges need to be overcome: a. Nanofabrication of macro/micro systems which incorporates the direct benefit of light weight (thus portability), low power consumption, faster response, higher sensitivity and batch production (low cost). b. Integration of advanced nano-materials to meet the performance/cost benefit trend. Nano-materials may offer new functionalities that were previously underutilized in the macro/micro dimension. c. Energy efficiency to reduce power consumption and to supply enough power to meet that low power demand. We present a pragmatic perspective on a self-powered integrated System on Chip (SoC). We envision the integrated device will have two objectives: low power consumption/dissipation and on-chip power generation for implementation into handheld or remote technologies for defense, space, harsh environments and medical applications. This paper provides insight on materials choices, intelligent circuit design, and CMOS compatible integration.

  6. Tunable on chip optofluidic laser

    DEFF Research Database (Denmark)

    Bakal, Avraham; Vannahme, Christoph; Kristensen, Anders

    2015-01-01

    A chip scale tunable laser in the visible spectral band is realized by generating a periodic droplet array inside a microfluidic channel. Combined with a gain medium within the droplets, the periodic structure provides the optical feedback of the laser. By controlling the pressure applied to two...... separate inlets we can change the period of the droplet array. As a result, the lasing frequency is tuned over a broad spectral range. Using this configuration, we demonstrate wavelength tunability of about 70 nm and lasing threshold of about 15 μJ/mm2....

  7. CHIP: A new modulator of human malignant disorders

    OpenAIRE

    Cao, Zhe; Li, Guanqiao; Shao, Qianqian; Yang,Gang; Zheng, Lianfang; Zhang, Taiping; Zhao, Yupei

    2016-01-01

    Carboxyl terminus of Hsc70-interacting protein (CHIP) is known as a chaperone-associated E3 for a variety of protein substrates. It acts as a link between molecular chaperones and ubiquitin–proteasome system. Involved in the process of protein clearance, CHIP plays a critical role in maintaining protein homeostasis in diverse conditions. Here, we provide a comprehensive review of our current understanding of CHIP and summarize recent advances in CHIP biology, with a focus on CHIP in the setti...

  8. Expression and significance of CHIP in canine mammary gland tumors

    OpenAIRE

    Wang, Huanan; Yang, Xu; Jin, Yipeng; Pei, Shimin; Zhang, Di; Ma, Wen; Huang, Jian; QIU, Hengbin; Zhang, Xinke; JIANG, Qiuyue; Sun, Weidong; Zhang, Hong; Lin, Degui

    2015-01-01

    CHIP (Carboxy terminus of Hsc70 Interacting Protein) is an E3 ubiquitin ligase that can induce ubiquitination and degradation of several oncogenic proteins. The expression of CHIP is frequently lower in human breast cancer than in normal breast tissue. However, the expression and role of CHIP in the canine mammary gland tumor (CMGT) remain unclear. We investigated the potential correlation between CHIP expression and mammary gland tumor prognosis in female dogs. CHIP expression was measured i...

  9. Attachment method for stacked integrated circuit (IC) chips

    Energy Technology Data Exchange (ETDEWEB)

    Bernhardt, Anthony F. (Berkeley, CA); Malba, Vincent (Livermore, CA)

    1999-01-01

    An attachment method for stacked integrated circuit (IC) chips. The method involves connecting stacked chips, such as DRAM memory chips, to each other and/or to a circuit board. Pads on the individual chips are rerouted to form pads on the side of the chip, after which the chips are stacked on top of each other whereby desired interconnections to other chips or a circuit board can be accomplished via the side-located pads. The pads on the side of a chip are connected to metal lines on a flexible plastic tape (flex) by anisotropically conductive adhesive (ACA). Metal lines on the flex are likewise connected to other pads on chips and/or to pads on a circuit board. In the case of a stack of DRAM chips, pads to corresponding address lines on the various chips may be connected to the same metal line on the flex to form an address bus. This method has the advantage of reducing the number of connections required to be made to the circuit board due to bussing; the flex can accommodate dimensional variation in the alignment of chips in the stack; bonding of the ACA is accomplished at low temperature and is otherwise simpler and less expensive than solder bonding; chips can be bonded to the ACA all at once if the sides of the chips are substantially coplanar, as in the case for stacks of identical chips, such as DRAM.

  10. Attachment method for stacked integrated circuit (IC) chips

    Energy Technology Data Exchange (ETDEWEB)

    Bernhardt, A.F.; Malba, V.

    1999-08-03

    An attachment method for stacked integrated circuit (IC) chips is disclosed. The method involves connecting stacked chips, such as DRAM memory chips, to each other and/or to a circuit board. Pads on the individual chips are rerouted to form pads on the side of the chip, after which the chips are stacked on top of each other whereby desired interconnections to other chips or a circuit board can be accomplished via the side-located pads. The pads on the side of a chip are connected to metal lines on a flexible plastic tape (flex) by anisotropically conductive adhesive (ACA). Metal lines on the flex are likewise connected to other pads on chips and/or to pads on a circuit board. In the case of a stack of DRAM chips, pads to corresponding address lines on the various chips may be connected to the same metal line on the flex to form an address bus. This method has the advantage of reducing the number of connections required to be made to the circuit board due to bussing; the flex can accommodate dimensional variation in the alignment of chips in the stack; bonding of the ACA is accomplished at low temperature and is otherwise simpler and less expensive than solder bonding; chips can be bonded to the ACA all at once if the sides of the chips are substantially coplanar, as in the case for stacks of identical chips, such as DRAM. 12 figs.

  11. Microchannel cooling of face down bonded chips

    Science.gov (United States)

    Bernhardt, Anthony F.

    1993-01-01

    Microchannel cooling is applied to flip-chip bonded integrated circuits, in a manner which maintains the advantages of flip-chip bonds, while overcoming the difficulties encountered in cooling the chips. The technique is suited to either multichip integrated circuit boards in a plane, or to stacks of circuit boards in a three dimensional interconnect structure. Integrated circuit chips are mounted on a circuit board using flip-chip or control collapse bonds. A microchannel structure is essentially permanently coupled with the back of the chip. A coolant delivery manifold delivers coolant to the microchannel structure, and a seal consisting of a compressible elastomer is provided between the coolant delivery manifold and the microchannel structure. The integrated circuit chip and microchannel structure are connected together to form a replaceable integrated circuit module which can be easily decoupled from the coolant delivery manifold and the circuit board. The coolant supply manifolds may be disposed between the circuit boards in a stack and coupled to supplies of coolant through a side of the stack.

  12. Three dimensional, multi-chip module

    Science.gov (United States)

    Bernhardt, Anthony F.; Petersen, Robert W.

    1993-01-01

    A plurality of multi-chip modules are stacked and bonded around the perimeter by sold-bump bonds to adjacent modules on, for instance, three sides of the perimeter. The fourth side can be used for coolant distribution, for more interconnect structures, or other features, depending on particular design considerations of the chip set. The multi-chip modules comprise a circuit board, having a planarized interconnect structure formed on a first major surface, and integrated circuit chips bonded to the planarized interconnect surface. Around the periphery of each circuit board, long, narrow "dummy chips" are bonded to the finished circuit board to form a perimeter wall. The wall is higher than any of the chips on the circuit board, so that the flat back surface of the board above will only touch the perimeter wall. Module-to-module interconnect is laser-patterned o the sides of the boards and over the perimeter wall in the same way and at the same time that chip to board interconnect may be laser-patterned.

  13. Whole-Teflon microfluidic chips.

    Science.gov (United States)

    Ren, Kangning; Dai, Wen; Zhou, Jianhua; Su, Jing; Wu, Hongkai

    2011-05-17

    Although microfluidics has shown exciting potential, its broad applications are significantly limited by drawbacks of the materials used to make them. In this work, we present a convenient strategy for fabricating whole-Teflon microfluidic chips with integrated valves that show outstanding inertness to various chemicals and extreme resistance against all solvents. Compared with other microfluidic materials [e.g., poly(dimethylsiloxane) (PDMS)] the whole-Teflon chip has a few more advantages, such as no absorption of small molecules, little adsorption of biomolecules onto channel walls, and no leaching of residue molecules from the material bulk into the solution in the channel. Various biological cells have been cultured in the whole-Teflon channel. Adherent cells can attach to the channel bottom, spread, and proliferate well in the channels (with similar proliferation rate to the cells in PDMS channels with the same dimensions). The moderately good gas permeability of the Teflon materials makes it suitable to culture cells inside the microchannels for a long time.

  14. Physiologically relevant organs on chips.

    Science.gov (United States)

    Yum, Kyungsuk; Hong, Soon Gweon; Healy, Kevin E; Lee, Luke P

    2014-01-01

    Recent advances in integrating microengineering and tissue engineering have generated promising microengineered physiological models for experimental medicine and pharmaceutical research. Here we review the recent development of microengineered physiological systems, or also known as "ogans-on-chips", that reconstitute the physiologically critical features of specific human tissues and organs and their interactions. This technology uses microengineering approaches to construct organ-specific microenvironments, reconstituting tissue structures, tissue-tissue interactions and interfaces, and dynamic mechanical and biochemical stimuli found in specific organs, to direct cells to assemble into functional tissues. We first discuss microengineering approaches to reproduce the key elements of physiologically important, dynamic mechanical microenvironments, biochemical microenvironments, and microarchitectures of specific tissues and organs in microfluidic cell culture systems. This is followed by examples of microengineered individual organ models that incorporate the key elements of physiological microenvironments into single microfluidic cell culture systems to reproduce organ-level functions. Finally, microengineered multiple organ systems that simulate multiple organ interactions to better represent human physiology, including human responses to drugs, is covered in this review. This emerging organs-on-chips technology has the potential to become an alternative to 2D and 3D cell culture and animal models for experimental medicine, human disease modeling, drug development, and toxicology.

  15. Assessing the Power of Exome Chips.

    Directory of Open Access Journals (Sweden)

    Christian Magnus Page

    Full Text Available Genotyping chips for rare and low-frequent variants have recently gained popularity with the introduction of exome chips, but the utility of these chips remains unclear. These chips were designed using exome sequencing data from mainly American-European individuals, enriched for a narrow set of common diseases. In addition, it is well-known that the statistical power of detecting associations with rare and low-frequent variants is much lower compared to studies exclusively involving common variants. We developed a simulation program adaptable to any exome chip design to empirically evaluate the power of the exome chips. We implemented the main properties of the Illumina HumanExome BeadChip array. The simulated data sets were used to assess the power of exome chip based studies for varying effect sizes and causal variant scenarios. We applied two widely-used statistical approaches for rare and low-frequency variants, which collapse the variants into genetic regions or genes. Under optimal conditions, we found that a sample size between 20,000 to 30,000 individuals were needed in order to detect modest effect sizes (0.5% 1% with 80% power. For small effect sizes (PAR <0.5%, 60,000-100,000 individuals were needed in the presence of non-causal variants. In conclusion, we found that at least tens of thousands of individuals are necessary to detect modest effects under optimal conditions. In addition, when using rare variant chips on cohorts or diseases they were not originally designed for, the identification of associated variants or genes will be even more challenging.

  16. ToxChip and its applications

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@\tToxChip is the molecular biological technology which has been developed based on genome and DNA microarray technologies. It will be able to make the sci-entists evaluate the toxicity of extraneous toxicants at the molecular level. ToxChip was successfully developed by a group of the National Institute of Environmental Health Sciences (NIEHS) researchers in the United States in 1999[1]. The technology bears revolutionary significance on the traditional toxicology. It foretells the epoch in which DNA effects of environmental dangers and toxi-cants can be made certain rapidly and efficiently to fall. ToxChip will pioneer novel approaches for medicine, environmental and ecological toxicologies.

  17. Single Chip Sensing of Multiple Gas Flows

    CERN Document Server

    Bruschi, P; Piotto, M

    2008-01-01

    The fabrication and experimental characterization of a thermal flow meter, capable of detecting and measuring two independent gas flows with a single chip, is described. The device is based on a 4 x 4 mm2 silicon chip, where a series of differential micro-anemometers have been integrated together with standard electronic components by means of postprocessing techniques. The innovative aspect of the sensor is the use of a plastic adapter, thermally bonded to the chip, to convey the gas flow only to the areas where the sensors are located. The use of this inexpensive packaging procedure to include different sensing structures in distinct flow channels is demonstrated.

  18. Imaging Cold Molecules on a Chip

    CERN Document Server

    Marx, S; Abel, M J; Zehentbauer, T; Meijer, G; Santambrogio, G

    2013-01-01

    We present the integrated imaging of cold molecules in a microchip environment. The on-chip de- tection is based on REMPI, which is quantum-state-selective and generally applicable. We demon- strate and characterize time-resolved spatial imaging and subsequently use it to analyze the effect of a phase-space manipulation sequence aimed at compressing the velocity distribution of a molec- ular ensemble with a view to future high-resolution spectroscopic studies. The realization of such on-chip measurements adds the final fundamental component to the molecule chip, offering a new and promising route for investigating cold molecules.

  19. Solid state silicon based condenser microphone for hearing aid, has transducer chip and IC chip between intermediate chip and openings on both sides of intermediate chip, to allow sound towards diaphragm

    DEFF Research Database (Denmark)

    2000-01-01

    NOVELTY - A silicon transducer chip (1) has parallel backplate and movable diaphragm (12) and forms an electrical capacitor. The chip and electronic circuit chip (3) are provided on either sides of intermediate chip (2). The chip (2) has openings (4,10) between two sides of the chip, to allow sou...... inlet of microphone. External electrical connection can be made economically reliable and the thermal stress is avoided with the small size solid state silicon based condenser microphone....... towards diaphragm. Surface of the chip (2) has electrical conductors (14) to connect chip with IC chip (3). USE - For use in miniature electroacoustic devices such as hearing aid. ADVANTAGE - Since sound inlet is covered by filter, dust, moisture and other impurities do not obstruct interior and sound...

  20. Assessment of Deformation of Shear Localized Chip in High Speed Machining

    Institute of Scientific and Technical Information of China (English)

    T; C; LEE; W; S; LAU; S; K; CHAN

    2002-01-01

    As the cutting speed goes higher, the mechanism of chip deformation will be changed significantly, i.e., continuous chip in low cutting speed will shift to serrated chip with shear localization. For the shear localized chip, the parameters used to assess the chip deformation for continuous chip, such as shorten coefficient ξ, shear angle φ and shear strain ε, can not describe the chip deformation correctly or comprehensively. This paper deals with the assessment of chip deformation of shear localization. Th...

  1. On-chip power delivery and management

    CERN Document Server

    Vaisband, Inna P; Popovich, Mikhail; Mezhiba, Andrey V; Köse, Selçuk; Friedman, Eby G

    2016-01-01

    This book describes methods for distributing power in high speed, high complexity integrated circuits with power levels exceeding many tens of watts and power supplies below a volt. It provides a broad and cohesive treatment of power delivery and management systems and related design problems, including both circuit network models and design techniques for on-chip decoupling capacitors, providing insight and intuition into the behavior and design of on-chip power distribution systems. Organized into subareas to provide a more intuitive flow to the reader, this fourth edition adds more than a hundred pages of new content, including inductance models for interdigitated structures, design strategies for multi-layer power grids, advanced methods for efficient power grid design and analysis, and methodologies for simultaneously placing on-chip multiple power supplies and decoupling capacitors. The emphasis of this additional material is on managing the complexity of on-chip power distribution networks.

  2. Spacecraft on a Chip Development Project

    Data.gov (United States)

    National Aeronautics and Space Administration — System on a chip is a method to increase engineering efficiency. State of the art components are increasing in gate count as expected according to Moore’s law....

  3. Continuous Eligibility for Medicaid and CHIP Coverage

    Data.gov (United States)

    U.S. Department of Health & Human Services — States have the option to provide children with 12 months of continuous coverage through Medicaid and CHIP, even if the family experiences a change in income during...

  4. Dental Care for Medicaid and CHIP Enrollees

    Science.gov (United States)

    ... Close Home > Medicaid > Benefits > Dental Care Dental Care Dental Care Dental Care for Medicaid and CHIP Enrollees Dental health ... services and opportunities and challenges to obtaining care. Dental Benefits for Children in Medicaid Medicaid covers dental ...

  5. Medicaid CHIP Environmental Scanning and Program Char...

    Data.gov (United States)

    U.S. Department of Health & Human Services — ESPC development is sponsored by the CMS Center for Medicare and Medicaid Innovation in partnership with the Center for Medicaid and CHIP Services (CMCS) under the...

  6. Wafer of Intel Pentium 4 Prescott Chips

    CERN Multimedia

    Silicon wafer with hundreds of Penryn cores (microprocessor). There are around four times as many Prescott chips can be made per wafer than with the previous generation of Northwood-core Pentium 4 processors. It is faster and cheaper.

  7. Towards third generation pixel readout chips

    Energy Technology Data Exchange (ETDEWEB)

    Garcia-Sciveres, M., E-mail: mgarcia-sciveres@lbl.gov; Mekkaoui, A.; Ganani, D.

    2013-12-11

    We present concepts and prototyping results towards a third generation pixel readout chip. We consider the 130 nm feature size FE-I4 chip, in production for the ATLAS IBL upgrade, to be a second generation chip. A third generation chip would have to go significantly further. A possible direction is to make the IC design generic so that different experiments can configure it to meet significantly different requirements, without the need for everybody to develop their own ASIC from the ground up. In terms of target technology, a demonstrator 500-pixel matrix containing analog front ends only (no complex functionality), was designed and fabricated in 65 nm CMOS and irradiated with protons in December 2011 and May 2012.

  8. IC chip stress during plastic package molding

    Energy Technology Data Exchange (ETDEWEB)

    Palmer, D.W.; Benson, D.A.; Peterson, D.W.; Sweet, J.N.

    1998-02-01

    Approximately 95% of the world`s integrated chips are packaged using a hot, high pressure transfer molding process. The stress created by the flow of silica powder loaded epoxy can displace the fine bonding wires and can even distort the metalization patterns under the protective chip passivation layer. In this study the authors developed a technique to measure the mechanical stress over the surface of an integrated circuit during the molding process. A CMOS test chip with 25 diffused resistor stress sensors was applied to a commercial lead frame. Both compression and shear stresses were measured at all 25 locations on the surface of the chip every 50 milliseconds during molding. These measurements have a fine time and stress resolution which should allow comparison with computer simulation of the molding process, thus allowing optimization of both the manufacturing process and mold geometry.

  9. Event loss rates and readout chips

    CERN Document Server

    Schmelling, M

    1998-01-01

    98-57 The LHCb experiment aims at a deadtimeless readout of B­events at a primary bunch crossing rate of 40 MHz. In order to achieve this goal, information from all events must be stored in a pipeline with latency matched to the time needed for the Level 0 trigger decision. Accepted events, which constitute only a small fraction of the total sample, are stored in a fifo of a certain depth and read out with a fixed clock rate. The fifo, also referred to as multi­event or derandomizing buffer, is needed in order to even out statistical fluctuations in the trigger rate. Apart from the length of the pipeline, which determines the maximum latency of the chip, the crucial parameter characterizing a readout chip is the fraction of triggers lost due to limitations of the chip's architecture. This note describes how the different design parameters and operation conditions determine the chip's performance.

  10. Link between chips and cutting moments evolution

    CERN Document Server

    Cahuc, Olivier; Gérard, Alain; 10.4028/WWW.scientific.net/AMR.423.89

    2012-01-01

    The better understanding of the material cutting process has been shown with the benefit of the forces and moments measurement since some years ago. In paper, simultaneous six mechanical components and chip orientation measurements were realized during turning tests. During these tests, the influence of the depth of cut or feed rate has been observed and a link between the chip orientation and the moment vector orientation or the central axis characteristics has been shown.

  11. Open Tiled Manycore System-on-Chip

    OpenAIRE

    Wallentowitz, Stefan; Wagner, Philipp; Tempelmeier, Michael; Wild, Thomas; Herkersdorf, Andreas

    2013-01-01

    Manycore System-on-Chip include an increasing amount of processing elements and have become an important research topic for improvements of both hardware and software. While research can be conducted using system simulators, prototyping requires a variety of components and is very time consuming. With the Open Tiled Manycore System-on-Chip (OpTiMSoC) we aim at building such an environment for use in our and other research projects as prototyping platform. This paper describes the project goal...

  12. On-Chip Random Spectrometer

    CERN Document Server

    Redding, Brandon; Sarma, Raktim

    2013-01-01

    Light scattering in disordered media has been studied extensively due to its prevalence in natural and artificial systems [1]. In the field of photonics most of the research has focused on understanding and mitigating the effects of scattering, which are often detrimental. For certain applications, however, intentionally introducing disorder can actually improve the device performance, e.g., in photovoltaics optical scattering improves the efficiency of light harvesting [2-5]. Here, we utilize multiple scattering in a random photonic structure to build a compact on-chip spectrometer. The probe signal diffuses through a scattering medium generating wavelength-dependent speckle patterns which can be used to recover the input spectrum after calibration. Multiple scattering increases the optical pathlength by folding the paths in a confined geometry, enhancing the spectral decorrelation of speckle patterns and thus increasing the spectral resolution. By designing and fabricating the spectrometer on a silicon wafe...

  13. On-chip spiral spectrometer

    CERN Document Server

    Redding, Brandon; Bromberg, Yaron; Sarma, Raktim; Cao, Hui

    2016-01-01

    We designed an on-chip spectrometer based on an evanescently-coupled multimode spiral waveguide. Interference between the modes in the waveguide forms a wavelength-dependent speckle pattern which can be used as a fingerprint to identify the input wavelength after calibration. Evanescent coupling between neighboring arms of the spiral enhances the temporal spread of light propagating through the spiral, leading to a dramatic increase in the spectral resolution. Experimentally, we demonstrated that a 250 {\\mu}m radius spiral spectrometer provides a resolution of 0.01 nm at a wavelength of 1520 nm. Spectra containing 40 independent spectral channels can be recovered simultaneously and the operation bandwidth can be increased further when measuring sparse spectra.

  14. Integrated magneto-optical traps on a chip

    CERN Document Server

    Pollock, S; Laliotis, A; Hinds, E A

    2009-01-01

    We have integrated magneto-optical traps (MOTs) into an atom chip by etching pyramids into a silicon wafer. These have been used to trap atoms on the chip, directly from a room temperature vapor of rubidium. This new atom trapping method provides a simple way to integrate several atom sources on the same chip. It represents a substantial advance in atom chip technology and offers new possibilities for atom chip applications such as integrated single atom or photon sources and molecules on a chip.

  15. Fabrication technology of integrated fiber microfluidic electrophoresis chip

    Institute of Scientific and Technical Information of China (English)

    LI MengChun

    2007-01-01

    The technology of PCB was used to fabricate the chip mould, and the microfluidic electrophoresis chip was fabricated with PDMS material. The fiber integrated on the chip was used as the transmission medium, so the light spot size was near the depth of microchannel. The detection sensitivity was improved, and the optical focusing system was spared. The fabrication process, sealing methods and structure characteristic of PDMS microfluidic electrophoresis chips were discussed. The experiment was achieved by using the fabricated chip to separate FITC fluorescein and FITC-labeled amino acid mixture reagent, and the feasibility of the chip was validated.

  16. Microfabrication of human organs-on-chips.

    Science.gov (United States)

    Huh, Dongeun; Kim, Hyun Jung; Fraser, Jacob P; Shea, Daniel E; Khan, Mohammed; Bahinski, Anthony; Hamilton, Geraldine A; Ingber, Donald E

    2013-11-01

    'Organs-on-chips' are microengineered biomimetic systems containing microfluidic channels lined by living human cells, which replicate key functional units of living organs to reconstitute integrated human organ-level pathophysiology in vitro. These microdevices can be used to test efficacy and toxicity of drugs and chemicals, and to create in vitro models of human disease. Thus, they potentially represent low-cost alternatives to conventional animal models for pharmaceutical, chemical and environmental applications. Here we describe a protocol for the fabrication, microengineering and operation of these microfluidic organ-on-chip systems. First, microengineering is used to fabricate a multilayered microfluidic device that contains two parallel elastomeric microchannels separated by a thin porous flexible membrane, along with two full-height, hollow vacuum chambers on either side; this requires ∼3.5 d to complete. To create a 'breathing' lung-on-a-chip that mimics the mechanically active alveolar-capillary interface of the living human lung, human alveolar epithelial cells and microvascular endothelial cells are cultured in the microdevice with physiological flow and cyclic suction applied to the side chambers to reproduce rhythmic breathing movements. We describe how this protocol can be easily adapted to develop other human organ chips, such as a gut-on-a-chip lined by human intestinal epithelial cells that experiences peristalsis-like motions and trickling fluid flow. Also, we discuss experimental techniques that can be used to analyze the cells in these organ-on-chip devices.

  17. Advanced atom chips with two metal layers.

    Energy Technology Data Exchange (ETDEWEB)

    Stevens, James E.; Blain, Matthew Glenn; Benito, Francisco M.; Biedermann, Grant

    2010-12-01

    A design concept, device layout, and monolithic microfabrication processing sequence have been developed for a dual-metal layer atom chip for next-generation positional control of ultracold ensembles of trapped atoms. Atom chips are intriguing systems for precision metrology and quantum information that use ultracold atoms on microfabricated chips. Using magnetic fields generated by current carrying wires, atoms are confined via the Zeeman effect and controllably positioned near optical resonators. Current state-of-the-art atom chips are single-layer or hybrid-integrated multilayer devices with limited flexibility and repeatability. An attractive feature of multi-level metallization is the ability to construct more complicated conductor patterns and thereby realize the complex magnetic potentials necessary for the more precise spatial and temporal control of atoms that is required. Here, we have designed a true, monolithically integrated, planarized, multi-metal-layer atom chip for demonstrating crossed-wire conductor patterns that trap and controllably transport atoms across the chip surface to targets of interest.

  18. A simple clockless Network-on-Chip for a commercial audio DSP chip

    DEFF Research Database (Denmark)

    Stensgaard, Mikkel Bystrup; Bjerregaard, Tobias; Sparsø, Jens;

    2006-01-01

    We design a very small, packet-switched, clockless Network-on-Chip (NoC) as a replacement for the existing crossbar-based communication infrastructure in a commercial audio DSP chip. Both solutions are laid out in a 0.18 um process, and compared in terms of area, power consumption and routing...

  19. Flip chip assembly of thinned chips for hybrid pixel detector applications

    CERN Document Server

    Fritzsch, T; Woehrmann, M; Rothermund, M; Huegging, F; Ehrmann, O; Oppermann, H; Lang, K.D

    2014-01-01

    There is a steady trend to ultra-thin microelectronic devices. Especially for future particle detector systems a reduced readout chip thickness is required to limit the loss of tracking precision due to scattering. The reduction of silicon thickness is performed at wafer level in a two-step thinning process. To minimize the risk of wafer breakage the thinned wafer needs to be handled by a carrier during the whole process chain of wafer bumping. Another key process is the flip chip assembly of thinned readout chips onto thin sensor tiles. Besides the prevention of silicon breakage the minimization of chip warpage is one additional task for a high yield and reliable flip chip process. A new technology using glass carrier wafer will be described in detail. The main advantage of this technology is the combination of a carrier support during wafer processing and the chip support during flip chip assembly. For that a glass wafer is glue-bonded onto the backside of the thinned readout chip wafer. After the bump depo...

  20. On-chip cell analysis platform: Implementation of contact fluorescence microscopy in microfluidic chips

    Science.gov (United States)

    Takehara, Hiroaki; Kazutaka, Osawa; Haruta, Makito; Noda, Toshihiko; Sasagawa, Kiyotaka; Tokuda, Takashi; Ohta, Jun

    2017-09-01

    Although fluorescence microscopy is the gold standard tool for biomedical research and clinical applications, their use beyond well-established laboratory infrastructures remains limited. The present study investigated a novel on-chip cell analysis platform based on contact fluorescence microscopy and microfluidics. Combined use of a contact fluorescence imager based on complementary metal-oxide semiconductor technology and an ultra-thin glass bottom microfluidic chip enabled both to observe living cells with minimal image distortion and to ease controlling and handling of biological samples (e.g. cells and biological molecules) in the imaged area. A proof-of-concept experiment of on-chip detection of cellular response to endothelial growth factor demonstrated promising use for the recently developed on-chip cell analysis platform. Contact fluorescence microscopy has numerous desirable features including compatibility with plastic microfluidic chips and compatibility with the electrical control system, and thus will fulfill the requirements of a fully automated cell analysis system.

  1. The RootChip: an integrated microfluidic chip for plant science.

    Science.gov (United States)

    Grossmann, Guido; Guo, Woei-Jiun; Ehrhardt, David W; Frommer, Wolf B; Sit, Rene V; Quake, Stephen R; Meier, Matthias

    2011-12-01

    Studying development and physiology of growing roots is challenging due to limitations regarding cellular and subcellular analysis under controlled environmental conditions. We describe a microfluidic chip platform, called RootChip, that integrates live-cell imaging of growth and metabolism of Arabidopsis thaliana roots with rapid modulation of environmental conditions. The RootChip has separate chambers for individual regulation of the microenvironment of multiple roots from multiple seedlings in parallel. We demonstrate the utility of The RootChip by monitoring time-resolved growth and cytosolic sugar levels at subcellular resolution in plants by a genetically encoded fluorescence sensor for glucose and galactose. The RootChip can be modified for use with roots from other plant species by adapting the chamber geometry and facilitates the systematic analysis of root growth and metabolism from multiple seedlings, paving the way for large-scale phenotyping of root metabolism and signaling.

  2. The RootChip: An Integrated Microfluidic Chip for Plant Science[W][OA

    Science.gov (United States)

    Grossmann, Guido; Guo, Woei-Jiun; Ehrhardt, David W.; Frommer, Wolf B.; Sit, Rene V.; Quake, Stephen R.; Meier, Matthias

    2011-01-01

    Studying development and physiology of growing roots is challenging due to limitations regarding cellular and subcellular analysis under controlled environmental conditions. We describe a microfluidic chip platform, called RootChip, that integrates live-cell imaging of growth and metabolism of Arabidopsis thaliana roots with rapid modulation of environmental conditions. The RootChip has separate chambers for individual regulation of the microenvironment of multiple roots from multiple seedlings in parallel. We demonstrate the utility of The RootChip by monitoring time-resolved growth and cytosolic sugar levels at subcellular resolution in plants by a genetically encoded fluorescence sensor for glucose and galactose. The RootChip can be modified for use with roots from other plant species by adapting the chamber geometry and facilitates the systematic analysis of root growth and metabolism from multiple seedlings, paving the way for large-scale phenotyping of root metabolism and signaling. PMID:22186371

  3. Advanced Flip Chips in Extreme Temperature Environments

    Science.gov (United States)

    Ramesham, Rajeshuni

    2010-01-01

    The use of underfill materials is necessary with flip-chip interconnect technology to redistribute stresses due to mismatching coefficients of thermal expansion (CTEs) between dissimilar materials in the overall assembly. Underfills are formulated using organic polymers and possibly inorganic filler materials. There are a few ways to apply the underfills with flip-chip technology. Traditional capillary-flow underfill materials now possess high flow speed and reduced time to cure, but they still require additional processing steps beyond the typical surface-mount technology (SMT) assembly process. Studies were conducted using underfills in a temperature range of -190 to 85 C, which resulted in an increase of reliability by one to two orders of magnitude. Thermal shock of the flip-chip test articles was designed to induce failures at the interconnect sites (-40 to 100 C). The study on the reliability of flip chips using underfills in the extreme temperature region is of significant value for space applications. This technology is considered as an enabling technology for future space missions. Flip-chip interconnect technology is an advanced electrical interconnection approach where the silicon die or chip is electrically connected, face down, to the substrate by reflowing solder bumps on area-array metallized terminals on the die to matching footprints of solder-wettable pads on the chosen substrate. This advanced flip-chip interconnect technology will significantly improve the performance of high-speed systems, productivity enhancement over manual wire bonding, self-alignment during die joining, low lead inductances, and reduced need for attachment of precious metals. The use of commercially developed no-flow fluxing underfills provides a means of reducing the processing steps employed in the traditional capillary flow methods to enhance SMT compatibility. Reliability of flip chips may be significantly increased by matching/tailoring the CTEs of the substrate

  4. China unveils its first full image of the Moon

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    @@ The country's first full map of the Moon has recently been released by the State Administration of Science,Technology and Industry for National Defense. The image, which was produced on the basis of data obtained by the Chang'e-1, China's first lunar probe, over the past one year or so, was presented to the National Museum of China on 12 November, 2008, in Beijing.

  5. Towards integrated modelling: full image simulations for WEAVE

    Science.gov (United States)

    Dalton, Gavin; Ham, Sun Jeong; Trager, Scott; Abrams, Don Carlos; Bonifacio, Piercarlo; Aguerri, J. A. L.; Middleton, Kevin; Benn, Chris; Rogers, Kevin; Stuik, Remko; Carrasco, Esperanza; Vallenari, Antonella; Jin, Shoko; Lewis, Jim

    2016-08-01

    We present an integrated end-end simulation of the spectral images that will be obtained by the weave spectrograph, which aims to include full modelling of all effects from the top of the atmosphere to the detector. These data are based in input spectra from a combination of library spectra and synthetic models, and will be used to provide inputs for an endend test of the full weave data pipeline and archive systems, prior to 1st light of the instrument.

  6. Experiment list: SRX769793 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Primary thioglycollate-elicited peritoneal macrophages || strain=C57Bl6 || chip t...arget=RXR || chip antibody=sc-553, sc-774 || genotype=wild-type || cell type=macrophages http://dbarchive.bi

  7. Experiment list: SRX087269 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available -RXRa || chip antibody supplier=in-house antibody [generated by immunization of r...ce_name=embryonal carcinoma cells || cell line=F9 embryonal carcinoma cells || chip antibody=polyclonal anti

  8. Experiment list: SRX821821 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available PPARG ChIP-seq || tissue=SQ White Adipose Tissue || chip antibody=anti-PPAR? antibody || chip antibody vendor=Santa Cruz Biotechnolog...ies http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/each

  9. Novel High Pressure Pump-on-a-Chip Technology Project

    Data.gov (United States)

    National Aeronautics and Space Administration — HJ Science & Technology, Inc proposes to develop a novel high pressure "pump-on-a-chip" and "valve-on-a-chip" microfluidic technology for NASA planetary science...

  10. Experiment list: SRX112178 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available line=OS25 ES cells || chip antibody=8WG16 (MMS-126R, Covance) || chip antibody manufacturer=Covance || chromatin=Fixed || beads=Magn...etic beads http://dbarchive.biosciencedbc.jp/kyushu-u/mm

  11. Experiment list: SRX974676 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ure || genotype/variation=pcf11-9 mutant || growth temperature=grown at 25C || chip antibody=CMA601 antibody || chip antibody referen...ce=PMID 25252976 http://dbarchive.biosciencedbc.jp/kyush

  12. Experiment list: SRX974674 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ure || genotype/variation=pcf11-2 mutant || growth temperature=grown at 25C || chip antibody=CMA601 antibody || chip antibody referen...ce=PMID 25252976 http://dbarchive.biosciencedbc.jp/kyush

  13. Experiment list: SRX180159 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available sd || cell type=hemogenic endothelium || chip antibody=CEBPb || chip antibody vendor=santa cruz biotechnol...ogy http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/eachData/bw/SRX180159.bw http://

  14. Experiment list: SRX821815 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available PPARG ChIP-seq || tissue=SQ White Adipose Tissue || chip antibody=anti-PPAR? antibody || chip antibody vendor=Santa Cruz Biotechnolog...ies http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/each

  15. Experiment list: SRX821820 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available PPARG ChIP-seq || tissue=SQ White Adipose Tissue || chip antibody=anti-PPAR? antibody || chip antibody vendor=Santa Cruz Biotechnolog...ies http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/each

  16. Experiment list: SRX716558 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available toma cells || cell line=SF268 || cell type=Glioblastoma cells || chip antibody=TEF-1 || chip antibody vendor=BD Transduction Laborato...ries http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/eac

  17. Experiment list: SRX684292 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available TR-Luciferase cells || cell type=HeLa-LTR-Luciferase cells || chip antibody=Anti-Spt5 || chip antibody vendor=BD Transduction Laborat...ories http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/ea

  18. Experiment list: SRX716559 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available stoma cells || cell line=SF268 || cell type=Glioblastoma cells || chip antibody=TEF-1 || chip antibody vendor=BD Transduction Laborat...ories http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/ea

  19. Experiment list: SRX821812 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available =PPARG ChIP-seq || tissue=SQ White Adipose Tissue || chip antibody=anti-PPAR? antibody || chip antibody vendor=Santa Cruz Biotechnolo...gies http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/eac

  20. Experiment list: SRX821819 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available =PPARG ChIP-seq || tissue=SQ White Adipose Tissue || chip antibody=anti-PPAR? antibody || chip antibody vendor=Santa Cruz Biotechnolo...gies http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/eac

  1. Experiment list: SRX821818 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available =PPARG ChIP-seq || tissue=SQ White Adipose Tissue || chip antibody=anti-PPAR? antibody || chip antibody vendor=Santa Cruz Biotechnolo...gies http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/eac

  2. Experiment list: SRX821806 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available PPARG ChIP-seq || tissue=SQ White Adipose Tissue || chip antibody=anti-PPAR? antibody || chip antibody vendor=Santa Cruz Biotechnolog...ies http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/each

  3. Experiment list: SRX821809 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available PPARG ChIP-seq || tissue=SQ White Adipose Tissue || chip antibody=anti-PPAR? antibody || chip antibody vendor=Santa Cruz Biotechnolog...ies http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/each

  4. Experiment list: SRX367329 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available hnology) || sirna transfection=siJMJD6 http://dbarchive....e=HEK293T cell || cell line=Human Embryonic Kidney 293 cells || chip antibody=CDK9 || chip antibody details=2316S (Cell Signaling Tec

  5. Experiment list: SRX367328 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available nology) || sirna transfection=siCTL http://dbarchive.bio...=HEK293T cell || cell line=Human Embryonic Kidney 293 cells || chip antibody=CDK9 || chip antibody details=2316S (Cell Signaling Tech

  6. Experiment list: SRX367330 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available nology) || sirna transfection=siBrd4 http://dbarchive.bi...=HEK293T cell || cell line=Human Embryonic Kidney 293 cells || chip antibody=CDK9 || chip antibody details=2316S (Cell Signaling Tech

  7. Experiment list: SRX107354 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available matin IP against RXRa and RARg. In house polyclonal antibodies generated by immun...CSKPGPHPKASSEDEAPGGQGKRGQSPQPD)] || chip antibody=in-house polyclonal Ab against RXRa and RAR || chip antibo

  8. Experiment list: SRX107356 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ll type=embryonal carcinoma cells || cell line=F9 || comment=Chromatin IP against RXRa. In house polyclonal ...PB105 (MDTKHFLPLDFSTQVNSSSLNSPTGRGC)] || chip antibody=in-house polyclonal Ab against RXRa || chip antibody

  9. Materials for microfluidic chip fabrication.

    Science.gov (United States)

    Ren, Kangning; Zhou, Jianhua; Wu, Hongkai

    2013-11-19

    Through manipulating fluids using microfabricated channel and chamber structures, microfluidics is a powerful tool to realize high sensitive, high speed, high throughput, and low cost analysis. In addition, the method can establish a well-controlled microenivroment for manipulating fluids and particles. It also has rapid growing implementations in both sophisticated chemical/biological analysis and low-cost point-of-care assays. Some unique phenomena emerge at the micrometer scale. For example, reactions are completed in a shorter amount of time as the travel distances of mass and heat are relatively small; the flows are usually laminar; and the capillary effect becomes dominant owing to large surface-to-volume ratios. In the meantime, the surface properties of the device material are greatly amplified, which can lead to either unique functions or problems that we would not encounter at the macroscale. Also, each material inherently corresponds with specific microfabrication strategies and certain native properties of the device. Therefore, the material for making the device plays a dominating role in microfluidic technologies. In this Account, we address the evolution of materials used for fabricating microfluidic chips, and discuss the application-oriented pros and cons of different materials. This Account generally follows the order of the materials introduced to microfluidics. Glass and silicon, the first generation microfluidic device materials, are perfect for capillary electrophoresis and solvent-involved applications but expensive for microfabriaction. Elastomers enable low-cost rapid prototyping and high density integration of valves on chip, allowing complicated and parallel fluid manipulation and in-channel cell culture. Plastics, as competitive alternatives to elastomers, are also rapid and inexpensive to microfabricate. Their broad variety provides flexible choices for different needs. For example, some thermosets support in-situ fabrication of

  10. Modelling, Synthesis, and Configuration of Networks-on-Chips

    DEFF Research Database (Denmark)

    Stuart, Matthias Bo

    This thesis presents three contributions in two different areas of network-on-chip and system-on-chip research: Application modelling and identifying and solving different optimization problems related to two specific network-on-chip architectures. The contribution related to application modellin...... for solving the network synthesis problem in the MANGO network-on-chip, and the identification and formalization of the ReNoC configuration problem together with three heuristics for solving it....

  11. Development of gold based solder candidates for flip chip assembly

    DEFF Research Database (Denmark)

    Chidambaram, Vivek; Hald, John; Hattel, Jesper Henri

    2009-01-01

    Flip chip technology is now rapidly replacing the traditional wire bonding interconnection technology in the first level packaging applications due to the miniaturization drive in the microelectronics industry. Flip chip assembly currently involves the use of high lead containing solders for inte......Flip chip technology is now rapidly replacing the traditional wire bonding interconnection technology in the first level packaging applications due to the miniaturization drive in the microelectronics industry. Flip chip assembly currently involves the use of high lead containing solders...

  12. Experiment list: SRX490476 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NA 176403891,89.2,68.4,2180 GSM1346039: TAF9B ChIP; Mus musculus; ChIP-Seq source_name=EB-Motor neuron, WT, ...TAF9B ChIP || strain/background=C57BL/6 || genotype/variation=wild type || cell type=EB-Motor neuron || chip

  13. A Neuron- and a Synapse Chip for Artificial Neural Networks

    DEFF Research Database (Denmark)

    Lansner, John; Lehmann, Torsten

    1992-01-01

    A cascadable, analog, CMOS chip set has been developed for hardware implementations of artificial neural networks (ANN's):I) a neuron chip containing an array of neurons with hyperbolic tangent activation functions and adjustable gains, and II) a synapse chip (or a matrix-vector multiplier) where...

  14. Packetizing OCP Transactions in the MANGO Network-on-Chip

    DEFF Research Database (Denmark)

    Bjerregaard, Tobias; Sparsø, Jens

    2006-01-01

    The scaling of CMOS technology causes a widening gap between the performance of on-chip communication and computation. This calls for a communication-centric design flow. The MANGO network-on-chip architecture enables globally asynchronous locally synchronous (GALS) system-on-chip design, while...

  15. Experiment list: SRX110782 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available e3 (ab6002, abcam), Pol II (CTD4H8, Millipore) || chip antibody 1 manufacturer=ab...cam || chip antibody 2=Pol II (CTD4H8, Millipore) || chip antibody 2 manufacturer=Millipore http://dbarchive

  16. High Speed Global On-Chip Interconnects and Transceivers

    NARCIS (Netherlands)

    Mensink, E.

    2007-01-01

    The data rate of global on-chip interconnects (up to 10 mm) is limited by a large distributed resistance and capacitance. This thesis describes methods to increase the achievable data rate of global on-chip interconnects with minimal chip area and power consumption, while maintaining data integrity.

  17. On-chip separation and sensing systems for hydrodynamic chromatography

    NARCIS (Netherlands)

    Blom, M.T.

    2002-01-01

    The feasibility of on-chip analytical separations using planar hydrodynamic chromatography (HDC) in Pyrex-silicon and fused silica chips has been demonstrated. In order to sketch the analytical separations area in which the HDC chip has to operate, an introduction was given of important macro-scale

  18. Labs on a chip for health care applications

    NARCIS (Netherlands)

    van den Berg, Albert; Verpoorte, S; Andersson, Helene; Emneus, J; Pamme, N

    2010-01-01

    Three examples of Lab on Chip devices for medical applications are presented. First, a disposable, prefilled capillary electrophoresis chip for monitoring lithium in blood of manic depressive patients is discussed. It is demonstrated that the same chip-platform can also be used to measure sodium in

  19. Expression and significance of CHIP in canine mammary gland tumors.

    Science.gov (United States)

    Wang, Huanan; Yang, Xu; Jin, Yipeng; Pei, Shimin; Zhang, Di; Ma, Wen; Huang, Jian; Qiu, Hengbin; Zhang, Xinke; Jiang, Qiuyue; Sun, Weidong; Zhang, Hong; Lin, Degui

    2015-11-01

    CHIP (Carboxy terminus of Hsc70 Interacting Protein) is an E3 ubiquitin ligase that can induce ubiquitination and degradation of several oncogenic proteins. The expression of CHIP is frequently lower in human breast cancer than in normal breast tissue. However, the expression and role of CHIP in the canine mammary gland tumor (CMGT) remain unclear. We investigated the potential correlation between CHIP expression and mammary gland tumor prognosis in female dogs. CHIP expression was measured in 54 dogs by immunohistochemistry and real-time RT-PCR. CHIP protein expression was significantly correlated with the histopathological diagnosis, outcome of disease and tumor classification. The transcriptional level of CHIP was significantly higher in normal tissues (P=0.001) and benign tumors (P=0.009) than it in malignant tumors. CHIP protein expression was significantly correlated with the transcriptional level of CHIP (P=0.0102). The log-rank test survival curves indicated that patients with low expression of CHIP had shorter overall periods of survival than those with higher CHIP protein expression (P=0.050). Our data suggest that CHIP may play an important role in the formation and development of CMGTs and serve as a valuable prognostic marker and potential target for genetic therapy.

  20. 42 CFR 457.206 - Administrative appeals under CHIP.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Administrative appeals under CHIP. 457.206 Section... Claims; Reduction of Federal Medical Payments § 457.206 Administrative appeals under CHIP. Three distinct... provisions of 42 CFR part 430, subpart D of this chapter. (b) FFP in State CHIP expenditures....

  1. Energy Model of Networks-on-Chip and a Bus

    NARCIS (Netherlands)

    Wolkotte, P.T.; Smit, Gerardus Johannes Maria; Kavaldjiev, N.K.; Becker, Jens E.; Becker, Jürgen; Nurmi, J.; Takala, J.; Hamalainen, T.D.

    2005-01-01

    A Network-on-Chip (NoC) is an energy-efficient onchip communication architecture for Multi-Processor Systemon-Chip (MPSoC) architectures. In earlier papers we proposed two Network-on-Chip architectures based on packet-switching and circuit-switching. In this paper we derive an energy model for both

  2. Developing an Integrated Design Strategy for Chip Layout Optimization

    NARCIS (Netherlands)

    Wits, Wessel Willems; Jauregui Becker, Juan Manuel; van Vliet, Frank Edward; te Riele, G.J.

    2011-01-01

    This paper presents an integrated design strategy for chip layout optimization. The strategy couples both electric and thermal aspects during the conceptual design phase to improve chip performances; thermal management being one of the major topics. The layout of the chip circuitry is optimized acco

  3. Reliability evaluation of CIF (chip-in-flex) and COF (chip-on-flex) packages

    Science.gov (United States)

    Jang, Jae-Won; Suk, Kyoung-Lim; Paik, Kyung-Wook; Lee, Soon-Bok

    2010-03-01

    CIF (chip-in-flex) and COF (chip-on-flex) packages have the advantages of fine pitch capability, and flexibility. Anisotropic conductive films (ACFs) are used for the interconnection between chip and substrate. Display, mobile device, and semiconductor industry require for smaller and more integrated packages. Both CIF and COF packages are an alternative for the demands. However, there are some reliability problems of interconnection between the chip and substrate because the packages are subjected to various loading conditions. These may degrade the functionality of the packages. Therefore, reliability assessment of both packages is necessary. In this study, experimental tests were performed to evaluate the reliability of interconnection between the chip and substrate of CIF and COF packages. Thermal cycling tests were performed to evaluate the resistance against thermal fatigue. The shape and warpage of the chip of CIF and COF packages were observed using optical methods (e.g., shadow Moiré and Twyman/Green interferometry). These optical Moiré techniques are widely used for measuring small deformations in microelectronic packages. The stress distribution around the chip was evaluated through FEA (finite element analysis). In addition, we suggested modifying design parameter of CIF packages for the reliability enhancement.

  4. Neural Circuits on a Chip

    Directory of Open Access Journals (Sweden)

    Md. Fayad Hasan

    2016-09-01

    Full Text Available Neural circuits are responsible for the brain’s ability to process and store information. Reductionist approaches to understanding the brain include isolation of individual neurons for detailed characterization. When maintained in vitro for several days or weeks, dissociated neurons self-assemble into randomly connected networks that produce synchronized activity and are capable of learning. This review focuses on efforts to control neuronal connectivity in vitro and construct living neural circuits of increasing complexity and precision. Microfabrication-based methods have been developed to guide network self-assembly, accomplishing control over in vitro circuit size and connectivity. The ability to control neural connectivity and synchronized activity led to the implementation of logic functions using living neurons. Techniques to construct and control three-dimensional circuits have also been established. Advances in multiple electrode arrays as well as genetically encoded, optical activity sensors and transducers enabled highly specific interfaces to circuits composed of thousands of neurons. Further advances in on-chip neural circuits may lead to better understanding of the brain.

  5. Discovery Mondays: Chips with everything!

    CERN Multimedia

    2003-01-01

    Electronics to hear the sound of matter From the TV to the fridge, the wristwatch to the washing machine, hardly any consumer product in this day and age can escape the influence of electronics, and the ever more powerful microchip. So it's hardly surprising to learn that such sophisticated devices as particle detectors are bristling with the best and most powerful microchips technology has to offer! Particle detectors known as trackers are like 3-D digital cameras. They are used to detect the tracks of particles created in the accelerator and to pin down their momentum and thus their identity. A chip seen with a microscope.Come to Microcosm and see with your own eyes a silicon detector, packed full of electronic microchips. Get up closer with a microscope and admire the way in which the fine details of the etchings break down light. Further on, watch a TV as you've never done before - from the inside! Then try out our special simulation game that helps you understand the purpose of a particle detector. Bu...

  6. Rehydration characteristics and modeling of cassava chips

    Directory of Open Access Journals (Sweden)

    Ajala, A.S

    2015-05-01

    Full Text Available Cassava chips with dimension 4x2x0.2cm were re-hydrated in distilled water at 200C, 300C and 400C in a laboratory water bath. Kinetics of re-hydration was investigated using three different re-hydration models namely Peleg, exponential and Weibull. The pattern of water absorption was observed to be faster at the initial period of soaking. Higher temperature induces faster moisture absorption in the chips. Non linear regression analysis was used to fit in the experimental data and the coefficient of determination was found to be greater than 0.72 for all the models. The values of R2 , RMSE, MBE and reduced chi square showed that Weibull model best described the re-hydrating behaviour of the cassava chips.

  7. Variation Tolerant On-Chip Interconnects

    CERN Document Server

    Nigussie, Ethiopia Enideg

    2012-01-01

    This book presents design techniques, analysis and implementation of high performance and power efficient, variation tolerant on-chip interconnects.  Given the design paradigm shift to multi-core, interconnect-centric designs and the increase in sources of variability and their impact in sub-100nm technologies, this book will be an invaluable reference for anyone concerned with the design of next generation, high-performance electronics systems. Provides comprehensive, circuit-level explanation of high-performance, energy-efficient, variation-tolerant on-chip interconnect; Describes design techniques to mitigate problems caused by variation; Includes techniques for design and implementation of self-timed on-chip interconnect, delay variation insensitive communication protocols, high speed signaling techniques and circuits, bit-width independent completion detection and process, voltage and temperature variation tolerance.                          

  8. Multisensor smart system on a chip.

    Science.gov (United States)

    Sellami, Louiza; Newcomb, Robert W

    2010-01-01

    Sensors are becoming of considerable importance in several areas, particularly in health care. Therefore, the development of inexpensive and miniaturized sensors that are highly selective and sensitive, and for which control and analysis is present all on one chip is very desirable. These types of sensors can be implemented with microelectromechanical systems (MEMS), and because they are fabricated on a semiconductor substrate, additional signal processing circuitry can easily be integrated into the chip, thereby readily providing additional functions, such as multiplexing and analog-to-digital conversion. Here, we present a general framework for the design of a multisensor system on a chip, which includes intelligent signal processing, as well as a built-in self-test and parameter adjustment units. Specifically, we outline the system architecture and develop a transistorized bridge biosensor for monitoring changes in the dielectric constant of a fluid, which could be used for in-home monitoring of kidney function of patients with renal failure.

  9. Chip-based quantum key distribution

    Science.gov (United States)

    Sibson, P.; Erven, C.; Godfrey, M.; Miki, S.; Yamashita, T.; Fujiwara, M.; Sasaki, M.; Terai, H.; Tanner, M. G.; Natarajan, C. M.; Hadfield, R. H.; O'Brien, J. L.; Thompson, M. G.

    2017-02-01

    Improvement in secure transmission of information is an urgent need for governments, corporations and individuals. Quantum key distribution (QKD) promises security based on the laws of physics and has rapidly grown from proof-of-concept to robust demonstrations and deployment of commercial systems. Despite these advances, QKD has not been widely adopted, and large-scale deployment will likely require chip-based devices for improved performance, miniaturization and enhanced functionality. Here we report low error rate, GHz clocked QKD operation of an indium phosphide transmitter chip and a silicon oxynitride receiver chip--monolithically integrated devices using components and manufacturing processes from the telecommunications industry. We use the reconfigurability of these devices to demonstrate three prominent QKD protocols--BB84, Coherent One Way and Differential Phase Shift--with performance comparable to state-of-the-art. These devices, when combined with integrated single photon detectors, pave the way for successfully integrating QKD into future telecommunications networks.

  10. A compact PE memory for vision chips

    Science.gov (United States)

    Cong, Shi; Zhe, Chen; Jie, Yang; Nanjian, Wu; Zhihua, Wang

    2014-09-01

    This paper presents a novel compact memory in the processing element (PE) for single-instruction multiple-data (SIMD) vision chips. The PE memory is constructed with 8 × 8 register cells, where one latch in the slave stage is shared by eight latches in the master stage. The memory supports simultaneous read and write on the same address in one clock cycle. Its compact area of 14.33 μm2/bit promises a higher integration level of the processor. A prototype chip with a 64 × 64 PE array is fabricated in a UMC 0.18 μm CMOS technology. Five types of the PE memory cell structure are designed and compared. The testing results demonstrate that the proposed PE memory architecture well satisfies the requirement of the vision chip in high-speed real-time vision applications, such as 1000 fps edge extraction.

  11. Cold molecular ions on a chip

    CERN Document Server

    Mokhberi, A

    2014-01-01

    We report the sympathetic cooling and Coulomb crystallization of molecular ions above the surface of an ion-trap chip. N$_2^+$ and CaH$^+$ ions were confined in a surface-electrode radiofrequency ion trap and cooled by the interaction with laser-cooled Ca$^{+}$ ions to secular translational temperatures in the millikelvin range. The configuration of trapping potentials generated by the surface electrodes enabled the formation of planar bicomponent Coulomb crystals and the spatial separation of the molecular from the atomic ions on the chip. The structural and thermal properties of the Coulomb crystals were characterized using molecular dynamics simulations. The present study extends chip-based trapping techniques to Coulomb-crystallized molecular ions with potential applications in mass spectrometry, cold chemistry, quantum information science and spectroscopy.

  12. A microfluidic chip for ICPMS sample introduction.

    Science.gov (United States)

    Verboket, Pascal E; Borovinskaya, Olga; Meyer, Nicole; Günther, Detlef; Dittrich, Petra S

    2015-03-05

    This protocol discusses the fabrication and usage of a disposable low cost microfluidic chip as sample introduction system for inductively coupled plasma mass spectrometry (ICPMS). The chip produces monodisperse aqueous sample droplets in perfluorohexane (PFH). Size and frequency of the aqueous droplets can be varied in the range of 40 to 60 µm and from 90 to 7,000 Hz, respectively. The droplets are ejected from the chip with a second flow of PFH and remain intact during the ejection. A custom-built desolvation system removes the PFH and transports the droplets into the ICPMS. Here, very stable signals with a narrow intensity distribution can be measured, showing the monodispersity of the droplets. We show that the introduction system can be used to quantitatively determine iron in single bovine red blood cells. In the future, the capabilities of the introduction device can easily be extended by the integration of additional microfluidic modules.

  13. Pixel readout chip for the ATLAS experiment

    CERN Document Server

    Ackers, M; Blanquart, L; Bonzom, V; Comes, G; Fischer, P; Keil, M; Kühl, T; Meuser, S; Delpierre, P A; Treis, J; Raith, B A; Wermes, N

    1999-01-01

    Pixel detectors with a high granularity and a very large number of sensitive elements (cells) are a very recent development used for high precision particle detection. At the Large Hadron Collider LHC at CERN (Geneva) a pixel detector with 1.4*10/sup 8/ individual pixel cells is developed for the ATLAS detector. The concept is a hybrid detector. Consisting of a pixel sensor connected to a pixel electronics chip by bump and flip chip technology in one-to-one cell correspondence. The development and prototype results of the pixel front end chip are presented together with the physical and technical requirements to be met at LHC. Lab measurements are reported. (6 refs).

  14. CHIPS: The Cosmological HI Power Spectrum Estimator

    CERN Document Server

    Trott, Cathryn M; Procopio, Pietro; Wayth, Randall B; Mitchell, Daniel A; McKinley, Benjamin; Tingay, Steven J; Barry, N; Beardsley, A P; Bernardi, G; Bowman, Judd D; Briggs, F; Cappallo, R J; Carroll, P; de Oliveira-Costa, A; Dillon, Joshua S; Ewall-Wice, A; Feng, L; Greenhill, L J; Hazelton, B J; Hewitt, J N; Hurley-Walker, N; Johnston-Hollitt, M; Jacobs, Daniel C; Kaplan, D L; Kim, HS; Lenc, E; Line, J; Loeb, A; Lonsdale, C J; Morales, M F; Morgan, E; Neben, A R; Thyagarajan, Nithyanandan; Oberoi, D; Offringa, A R; Ord, S M; Paul, S; Pober, J C; Prabu, T; Riding, J; Shankar, N Udaya; Sethi, Shiv K; Srivani, K S; Subrahmanyan, R; Sullivan, I S; Tegmark, M; Webster, R L; Williams, A; Williams, C L; Wu, C; Wyithe, J S B

    2016-01-01

    Detection of the cosmological neutral hydrogen signal from the Epoch of Reionization, and estimation of its basic physical parameters, is the principal scientific aim of many current low-frequency radio telescopes. Here we describe the Cosmological HI Power Spectrum Estimator (CHIPS), an algorithm developed and implemented with data from the Murchison Widefield Array (MWA), to compute the two-dimensional and spherically-averaged power spectrum of brightness temperature fluctuations. The principal motivations for CHIPS are the application of realistic instrumental and foreground models to form the optimal estimator, thereby maximising the likelihood of unbiased signal estimation, and allowing a full covariant understanding of the outputs. CHIPS employs an inverse-covariance weighting of the data through the maximum likelihood estimator, thereby allowing use of the full parameter space for signal estimation ("foreground suppression"). We describe the motivation for the algorithm, implementation, application to ...

  15. ESPECIFICANDO FORMALMENTE TOPOLOGIAS PARA REDES EM CHIP

    Directory of Open Access Journals (Sweden)

    Eliselma Vieira dos Santos

    2012-03-01

    Full Text Available Este artigo trata da utilização de métodos formais na especificação de topologias para redes em chip. As redes em chip apresentam similaridades com as redes tradicionais, entretanto, por estarem inseridas em sistemas embarcados apresentam características mais restritivas do ponto de vista de espaço, consumo de energia e latência. A topologia descreve o fluxo de dados através da rede e a estrutura física de como os dispositivos estão conectados, bem como, pode determinar o grau de escalabilidade e o desempenho de um sistema como todo. Este artigo apresenta especificações de topologias de redes em chip, relevantes para o projeto de sistemas embarcados, as quais poderão ser utilizadas no processo de síntese de alto nível.

  16. Biostability of an implantable glucose sensor chip

    Science.gov (United States)

    Fröhlich, M.; Birkholz, M.; Ehwald, K. E.; Kulse, P.; Fursenko, O.; Katzer, J.

    2012-12-01

    Surface materials of an implantable microelectronic chip intended for medical applications were evaluated with respect to their long-term stability in bio-environments. The sensor chip shall apply in a glucose monitor by operating as a microviscosimeter according to the principle of affinity viscosimetry. A monolithic integration of a microelectromechanical system (MEMS) into the sensor chip was successfully performed in a combined 0.25 μm CMOS/BiCMOS technology. In order to study material durability and biostability of the surfaces, sensor chips were exposed to various in vitro and in vivo tests. Corrosional damage of SiON, SiO2 and TiN surfaces was investigated by optical microscopy, ellipsometry and AFM. The results served for optimizing the Back-end-of-Line (BEoL) stack, from which the MEMS was prepared. Corrosion of metal lines could significantly be reduced by improving the topmost passivation layer. The experiments revealed no visible damage of the actuator or other functionally important MEMS elements. Sensor chips were also exposed to human body fluid for three month by implantation into the abdomen of a volunteer. Only small effects were observed for layer thickness and Ra roughness after explantation. In particular, TiN as used for the actuator beam showed no degradation by biocorrosion. The highest degradation rate of about 50 nm per month was revealed for the SiON passivation layer. These results suggest that the sensor chip may safely operate in subcutaneous tissue for a period of several months.

  17. CHIP: A new modulator of human malignant disorders.

    Science.gov (United States)

    Cao, Zhe; Li, Guanqiao; Shao, Qianqian; Yang, Gang; Zheng, Lianfang; Zhang, Taiping; Zhao, Yupei

    2016-05-17

    Carboxyl terminus of Hsc70-interacting protein (CHIP) is known as a chaperone-associated E3 for a variety of protein substrates. It acts as a link between molecular chaperones and ubiquitin-proteasome system. Involved in the process of protein clearance, CHIP plays a critical role in maintaining protein homeostasis in diverse conditions. Here, we provide a comprehensive review of our current understanding of CHIP and summarize recent advances in CHIP biology, with a focus on CHIP in the setting of malignancies.

  18. On-chip antenna: Practical design and characterization considerations

    KAUST Repository

    Shamim, Atif

    2012-07-28

    This paper highlights the challenges of an emergent field, namely, on-chip antenna design. Consistent with the RF System-on-Chip (SoC) concept, co-design strategy for circuits and on-chip antennas is described. A number of design and layout issues, arising from the highly integrated nature of this kind of systems, are discussed. The characterization difficulties related to on-chip antennas radiation properties are also highlighted. Finally, a novel on-wafer test fixture is proposed to measure the gain and radiation pattern of the on-chip antennas in the anechoic chamber.

  19. CHIP: A new modulator of human malignant disorders

    Science.gov (United States)

    Shao, Qianqian; Yang, Gang; Zheng, Lianfang; Zhang, Taiping; Zhao, Yupei

    2016-01-01

    Carboxyl terminus of Hsc70-interacting protein (CHIP) is known as a chaperone-associated E3 for a variety of protein substrates. It acts as a link between molecular chaperones and ubiquitin–proteasome system. Involved in the process of protein clearance, CHIP plays a critical role in maintaining protein homeostasis in diverse conditions. Here, we provide a comprehensive review of our current understanding of CHIP and summarize recent advances in CHIP biology, with a focus on CHIP in the setting of malignancies. PMID:27007160

  20. An automatic system for elaboration of chip breaking diagrams

    DEFF Research Database (Denmark)

    Andreasen, Jan Lasson; De Chiffre, Leonardo

    1998-01-01

    A laboratory system for fully automatic elaboration of chip breaking diagrams has been developed and tested. The system is based on automatic chip breaking detection by frequency analysis of cutting forces in connection with programming of a CNC-lathe to scan different feeds, speeds and cutting...... depths. An evaluation of the system based on a total of 1671 experiments has shown that unfavourable snarled chips can be detected with 98% certainty which indeed makes the system a valuable tool in chip breakability tests. Using the system, chip breaking diagrams can be elaborated with a previously...

  1. MCMII and the TriP chip

    Energy Technology Data Exchange (ETDEWEB)

    Juan Estrada et al.

    2003-12-19

    We describe the development of the electronics that will be used to read out the Fiber Tracker and Preshower detectors in Run IIb. This electronics is needed for operation at 132ns bunch crossing, and may provide a measurement of the z coordinate of the Fiber Tracker hits when operating at 396ns bunch crossing. Specifically, we describe the design and preliminary tests of the Trip chip, MCM IIa, MCM IIb and MCM IIc. This document also serves as a user manual for the Trip chip and the MCM.

  2. Optical stretching on chip with acoustophoretic prefocusing

    DEFF Research Database (Denmark)

    Khoury Arvelo, Maria; Laub Busk, L.; Bruus, Henrik

    2012-01-01

    in the microchannel. Trapping and manipulation is demonstrated for dielectric beads. In addition, we show trapping, manipulation and stretching of red blood cells and vesicles, whereby we extract the elastic properties of these objects. Our design points towards the construction of a low-cost, high-throughput lab-on-a-chip...... prefocusing. This focusing mechanism aims for target particles to always ow in the correct height relative to the optical stretcher, and is induced by a piezo-electric ultrasound transducer attached underneath the chip and driven at a frequency leading to a vertical standing ultrasound wave...

  3. Tunable axial potentials for atom chip waveguides

    CERN Document Server

    Stickney, James A; Imhof, Eric; Kroese, Bethany R; Crow, Jonathon A R; Olson, Spencer E; Squires, Matthew B

    2014-01-01

    We present a method for generating algebraically precise magnetic potentials along the axis of a cold atom waveguide near the surface of an atom chip. With a single chip design consisting of several wire pairs, various axial potentials can be created, including double wells, triple wells, and pure harmonic traps with suppression of higher order terms. We characterize the error along a harmonic trap between the expected algebraic form and magnetic field simulations and find excel- lent agreement, particularly at small displacements from the trap center. Finally, we demonstrate experimental control over the bottom fields of an asymmetric double well potential.

  4. Communication architectures for systems-on-chip

    CERN Document Server

    Ayala, Jose L

    2011-01-01

    A presentation of state-of-the-art approaches from an industrial applications perspective, Communication Architectures for Systems-on-Chip shows professionals, researchers, and students how to attack the problem of data communication in the manufacture of SoC architectures. With its lucid illustration of current trends and research improving the performance, quality, and reliability of transactions, this is an essential reference for anyone dealing with communication mechanisms for embedded systems, systems-on-chip, and multiprocessor architectures--or trying to overcome existing limitations.

  5. Heat toxicant contaminant mitigation in potato chips

    DEFF Research Database (Denmark)

    Mariotti, Maria; Cortes, Pablo; Fromberg, Arvid

    2015-01-01

    was to mitigate the furan and acrylamide formation in potato chips without increasing their oil uptake by optimizing the blanching treatment before final frying. Potato slices were blanched in order to simultaneously leach out ascorbic acid and reducing sugars, the most important precursors of furan...... and acrylamide generation in thermally treated starchy foods. A central composite design was implemented to optimize the temperature-time blanching conditions under which furan, acrylamide and oil content in potato chips were minimized. The optimum blanching conditions were 64 degrees C and 17 min in which...

  6. Microfluidic chip-capillary electrophoresis devices

    CERN Document Server

    Fung, Ying Sing; Du, Fuying; Guo, Wenpeng; Ma, Tongmei; Nie, Zhou; Sun, Hui; Wu, Ruige; Zhao, Wenfeng

    2015-01-01

    Capillary electrophoresis (CE) and microfluidic chip (MC) devices are relatively mature technologies, but this book demonstrates how they can be integrated into a single, revolutionary device that can provide on-site analysis of samples when laboratory services are unavailable. By introducing the combination of CE and MC technology, Microfluidic Chip-Capillary Electrophoresis Devices broadens the scope of chemical analysis, particularly in the biomedical, food, and environmental sciences.The book gives an overview of the development of MC and CE technology as well as technology that now allows

  7. Developments of optimum flip-chip bonding process

    Science.gov (United States)

    Jang, Dong H.; Kang, Sa Y.; Lee, Y. M.; Oh, S. Y.

    1997-08-01

    Flip-chip soldering is the critical technology for solving the current issues of electronic packaging industries that require the high I/O's. In order to increase the manufacturing ability of flip-chip technology, however, yield and reliability tissues should overcome. In this study, optimum flip-chip bonding process has been developed by using the test chips that had the electroplated solder bumps. Test chips are composed of three different types that are i) peripheral array pad chip, ii) peripheral array pad chip, and iii) area array pad chip. Each test chip has the daisy chain to consider the effect of reliability test. The electrical resistance was measured before and after reliability test. Based on these measurement, failure mode resulted from the moisture absorption was studied using scanning acoustic microscope. To achieve an optimum reflow profile of solder bump, correct temperature profile was set up with respect to the resin base flux. Different bonding forces were tested. Four underfill encapsulants were evaluated for minimum voids that caused the severe defects after reliability test. Also, the gap heights were measured with respect to applied bonding force after underfill was performed. Results from the moisture absorption and thermal cycling were discussed for flip-chip bonding on BT-resin substrates. The test vehicles using flip-chip technology have passed moisture preconditioning and temperature cycling tests.

  8. Cool down computer chips with liquid metal device driven by the heat of chips

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ With the soaring advances in computational speed, thermal management becomes a major concern in computer systems. To remove heat generated by computer chips or very large scale integrated circuits, a research team headed by Prof.

  9. The Distributed Network Processor: a novel off-chip and on-chip interconnection network architecture

    CERN Document Server

    Biagioni, Andrea; Lonardo, Alessandro; Paolucci, Pier Stanislao; Perra, Mersia; Rossetti, Davide; Sidore, Carlo; Simula, Francesco; Tosoratto, Laura; Vicini, Piero

    2012-01-01

    One of the most demanding challenges for the designers of parallel computing architectures is to deliver an efficient network infrastructure providing low latency, high bandwidth communications while preserving scalability. Besides off-chip communications between processors, recent multi-tile (i.e. multi-core) architectures face the challenge for an efficient on-chip interconnection network between processor's tiles. In this paper, we present a configurable and scalable architecture, based on our Distributed Network Processor (DNP) IP Library, targeting systems ranging from single MPSoCs to massive HPC platforms. The DNP provides inter-tile services for both on-chip and off-chip communications with a uniform RDMA style API, over a multi-dimensional direct network with a (possibly) hybrid topology.

  10. Simulating the Effect of Modulated Tool-Path Chip Breaking On Surface Texture and Chip Length

    Energy Technology Data Exchange (ETDEWEB)

    Smith, K.S.; McFarland, J.T.; Tursky, D. A.; Assaid, T. S.; Barkman, W. E.; Babelay, Jr., E. F.

    2010-04-30

    One method for creating broken chips in turning processes involves oscillating the cutting tool in the feed direction utilizing the CNC machine axes. The University of North Carolina at Charlotte and the Y-12 National Security Complex have developed and are refining a method to reliably control surface finish and chip length based on a particular machine's dynamic performance. Using computer simulations it is possible to combine the motion of the machine axes with the geometry of the cutting tool to predict the surface characteristics and map the surface texture for a wide range of oscillation parameters. These data allow the selection of oscillation parameters to simultaneously ensure broken chips and acceptable surface characteristics. This paper describes the machine dynamic testing and characterization activities as well as the computational method used for evaluating and predicting chip length and surface texture.

  11. An analog CMOS chip set for neural networks with arbitrary topologies

    DEFF Research Database (Denmark)

    Lansner, John; Lehmann, Torsten

    1993-01-01

    An analog CMOS chip set for implementations of artificial neural networks (ANNs) has been fabricated and tested. The chip set consists of two cascadable chips: a neuron chip and a synapse chip. Neurons on the neuron chips can be interconnected at random via synapses on the synapse chips thus...... implementing an ANN with arbitrary topology. The neuron test chip contains an array of 4 neurons with well defined hyperbolic tangent activation functions which is implemented by using parasitic lateral bipolar transistors. The synapse test chip is a cascadable 4×4 matrix-vector multiplier with variable, 10-b...

  12. "Hook"-calibration of GeneChip-microarrays: Chip characteristics and expression measures

    Directory of Open Access Journals (Sweden)

    Krohn Knut

    2008-08-01

    Full Text Available Abstract Background Microarray experiments rely on several critical steps that may introduce biases and uncertainty in downstream analyses. These steps include mRNA sample extraction, amplification and labelling, hybridization, and scanning causing chip-specific systematic variations on the raw intensity level. Also the chosen array-type and the up-to-dateness of the genomic information probed on the chip affect the quality of the expression measures. In the accompanying publication we presented theory and algorithm of the so-called hook method which aims at correcting expression data for systematic biases using a series of new chip characteristics. Results In this publication we summarize the essential chip characteristics provided by this method, analyze special benchmark experiments to estimate transcript related expression measures and illustrate the potency of the method to detect and to quantify the quality of a particular hybridization. It is shown that our single-chip approach provides expression measures responding linearly on changes of the transcript concentration over three orders of magnitude. In addition, the method calculates a detection call judging the relation between the signal and the detection limit of the particular measurement. The performance of the method in the context of different chip generations and probe set assignments is illustrated. The hook method characterizes the RNA-quality in terms of the 3'/5'-amplification bias and the sample-specific calling rate. We show that the proper judgement of these effects requires the disentanglement of non-specific and specific hybridization which, otherwise, can lead to misinterpretations of expression changes. The consequences of modifying probe/target interactions by either changing the labelling protocol or by substituting RNA by DNA targets are demonstrated. Conclusion The single-chip based hook-method provides accurate expression estimates and chip-summary characteristics

  13. Increasing security in inter-chip communication

    Science.gov (United States)

    Edwards, Nathan J; Hamlet, Jason; Bauer, Todd; Helinski, Ryan

    2014-10-28

    An apparatus for increasing security in inter-chip communication includes a sending control module, a communication bus, and a receiving control module. The communication bus is coupled between the sending control module and the receiving control module. The sending control module operates to send data on the communication bus, disable the communication bus when threats are detected, or both.

  14. What's A Pixel Particle Sensor Chip?

    CERN Multimedia

    2008-01-01

    ATLAS particle physics experiment aided with collaboration ON Semiconductor was recently honored by the European Council for Nuclear Research (CERN), with an Industrial Award recognizing the company's contribution in supplying complex "Pixel Particle Sensor" chips for use in CERN's ATLAS particle physics experiment.

  15. Smart Chips for Smart Surroundings - 4S

    NARCIS (Netherlands)

    Schuler, Eberhard; König, Ralf; Becker, Jürgen; Rauwerda, Gerard; Burgwal, van de Marcel; Smit, Gerard J.M.; Cardoso, João M.P.; Hübner, Michael

    2011-01-01

    The overall mission of the 4S project (Smart Chips for Smart Surroundings) was to define and develop efficient flexible, reconfigurable core building blocks, including the supporting tools, for future Ambient System Devices. Reconfigurability offers the needed flexibility and adaptability, it provid

  16. On-chip mode division multiplexing technologies

    DEFF Research Database (Denmark)

    Ding, Yunhong; Frellsen, Louise Floor; Guan, Xiaowei

    2016-01-01

    using one-dimensional (1D) photonic crystal silicon waveguides. We furthermore use the fabricated devices to demonstrate on-chip point-to-point mode division multiplexing transmission, and all-optical signal processing by mode-selective wavelength conversion. Finally, we report an efficient silicon...

  17. Potential roughness near lithographically fabricated atom chips

    DEFF Research Database (Denmark)

    Krüger, Peter; Andersson, L. M.; Wildermuth, Stefan

    2007-01-01

    Potential roughness has been reported to severely impair experiments in magnetic microtraps. We show that these obstacles can be overcome as we measure disorder potentials that are reduced by two orders of magnitude near lithographically patterned high-quality gold layers on semiconductor atom chip...

  18. A Chip for an Implantable Neural Stimulator

    DEFF Research Database (Denmark)

    Gudnason, Gunnar; Bruun, Erik; Haugland, Morten

    2000-01-01

    transmission to the stimulator passes through a 5 MHz inductive link. From the signals transmitted to the stimulator, the chip is able to generate charge-balanced current pulses with a controllable length up to 256 µs and an amplitude up to 2 mA, for stimulation of nerve fibers. The quiescent current...

  19. PLC Multi-Chip Integration Technologies

    Institute of Scientific and Technical Information of China (English)

    Motohaya; Ishii

    2003-01-01

    This paper reviews recent progress on integrated multi-chip modules composed of silica-based planar lightwave circuits (PLCs) with a relatively high core-to-cladding index contrast A. These compact and highly functional modules were fabricated by using the PLC-PLC direct attachment technique.

  20. PLC Multi-Chip Integration Technologies

    Institute of Scientific and Technical Information of China (English)

    Motohaya Ishii

    2003-01-01

    This paper reviews recent progress on integrated multi-chip modules composed of silica-based planarlightwave circuits (PLCs) with a relatively high core-to-cladding index contrast △. These compact and highlyfunctional modules were fabricated by using the PLC-PLC direct attachment technique.

  1. Hybrid photonic chip interferometer for embedded metrology

    Science.gov (United States)

    Kumar, P.; Martin, H.; Maxwell, G.; Jiang, X.

    2014-03-01

    Embedded metrology is the provision of metrology on the manufacturing platform, enabling measurement without the removal of the work piece. Providing closer integration of metrology upon the manufacturing platform can lead to the better control and increased throughput. In this work we present the development of a high precision hybrid optical chip interferometer metrology device. The complete metrology sensor system is structured into two parts; optical chip and optical probe. The hybrid optical chip interferometer is based on a silica-on-silicon etched integrated-optic motherboard containing waveguide structures and evanescent couplers. Upon the motherboard, electro-optic components such as photodiodes and a semiconductor gain block are mounted and bonded to provide the required functionality. The key structure in the device is a tunable laser module based upon an external-cavity diode laser (ECDL). Within the cavity is a multi-layer thin film filter which is rotated to select the longitudinal mode at which the laser operates. An optical probe, which uses a blazed diffracting grating and collimating objective lens, focuses light of different wavelengths laterally over the measurand. Incident laser light is then tuned in wavelength time to effectively sweep an `optical stylus' over the surface. Wavelength scanning and rapid phase shifting can then retrieve the path length change and thus the surface height. We give an overview of the overall design of the final hybrid photonic chip interferometer, constituent components, device integration and packaging as well as experimental test results from the current version now under evaluation.

  2. On-chip entangled photon source

    Energy Technology Data Exchange (ETDEWEB)

    Soh, Daniel B. S.; Bisson, Scott E.

    2016-11-22

    Various technologies pertaining to an on-chip entangled photon source are described herein. A light source is used to pump two resonator cavities that are resonant at two different respective wavelengths and two different respective polarizations. The resonator cavities are coupled to a four-wave mixing cavity that receives the light at the two wavelengths and outputs polarization-entangled photons.

  3. Increasing security in inter-chip communication

    Energy Technology Data Exchange (ETDEWEB)

    Edwards, Nathan J.; Hamlet, Jason; Bauer, Todd; Helinski, Ryan

    2017-08-01

    An apparatus for increasing security in inter-chip communication includes a sending control module, a communication bus, and a receiving control module. The communication bus is coupled between the sending control module and the receiving control module. The sending control module operates to send data on the communication bus, disable the communication bus when threats are detected, or both.

  4. DEHYDRATION AND DEOILING OF METAL CHIP

    Directory of Open Access Journals (Sweden)

    O. M. Djakonov

    2011-01-01

    Full Text Available Influence of technology factors on efficiency of processes of dehydration and deoiling of metal chips is investigated. The new universal simple method of definition of coefficients of filtration and free infiltration of liquid in porous medium is offered.

  5. On Chip Spermatozoa and Leucocytes Counter

    NARCIS (Netherlands)

    Segerink, Loes; Sprenkels, Ad; Vermes, István; Berg, van den Albert; Kim, Tae Song; Lee, Yoon-Sik; Chung, Taek-Dong; Jeon, Noo Li; Lee, Sang-Hoon; Suh, Kahp-Yang; Choo, Jaebum; Kim, Yong-Kweon

    2009-01-01

    In this project we aim to develop a semen quality test system based on a lab-on-a-chip. Since an important quality parameter of semen is the concentration of spermatozoa, we focus on counting the spermatozoa by using impedance measurements in a microchannel. However, semen contains also an interferi

  6. The Kindness in a Bag of Chips

    Institute of Scientific and Technical Information of China (English)

    韩小庆

    2011-01-01

    Last Sunday, my son and I were in line at the Dollar store buying an assortment of products. In a line next to ours, a woman was waiting to make her 1 . She had a few necessities and one bag of chips.

  7. The Kindness in a Bag of Chips

    Institute of Scientific and Technical Information of China (English)

    韩小庆

    2011-01-01

    难度:★★★☆☆词数:406建议阅读时间:10分钟Last Sunday, my son and I were in line at the Dollar store buying an assortment of products. In a line next to ours, a woman was waiting to make her 1 . She had a few necessities and one bag of chips.

  8. Writing for a Change, Writing for Chip

    Science.gov (United States)

    Berry, Patrick W.

    2014-01-01

    What does it mean to write for change? How do we negotiate the space between hope and critique? Drawing on Dewey's notion of a common faith, this article contemplates what the author learned from Chip Bruce. It suggests that when we compartmentalize the ideal and the everyday, the hopeful and the critical, we reduce the complexity of human…

  9. The V-Chip--Victory or Vendetta?

    Science.gov (United States)

    Payne, Ron

    1997-01-01

    Parents can install the v-chip microchip in their televisions to block out programs high in violence, sex, or other objectional material. Examines the views of supporters, who see it as a coping tool for the information age and of detractors who see it as an affront to the First Amendment guarantee of free speech. (SM)

  10. DNA-enrichment microfluidic chip for chromatin immunoprecipitation.

    Science.gov (United States)

    Oh, Hyun Jik; Park, Joong Yull; Park, Sung Eun; Lee, Bo Yun; Park, Jong Sung; Kim, Suel-Kee; Yoon, Tae Joong; Lee, Sang-Hoon

    2009-04-15

    Chromatin immunoprecipitation (ChIP) is a powerful and widely applied technique for detecting association of individual proteins with specific genomic regions; the technique requires several complex steps and is tedious. In this paper, we develop a microbead-packed microfluidic chip which eliminates most of the laborious, time-consuming, and skill-dependent processes of the ChIP procedure. A computational fluid dynamics model was established to analyze fluidic behavior in a microbead-packed microchannel. With the use of the new chip, a ChIP procedure was performed to purify the GAPDH (glyceraldehyde 3-phosphate dehydrogenase) gene from human embryonic kidney cells (cell line 293). The ChIP capability of the microfluidic chip was evaluated and compared with that of a commercial assay kit; the precipitation performance of both methods was almost identical as shown by quantitative measurement of DNA. However, our chip offers the advantage of low resin volume, and the experimental time is greatly reduced. In addition, our method is less dependent on individual technical skill. Therefore, we expect that our microfluidic chip-based ChIP method will be widely used in DNA-, gene-, and protein-related research and will improve experimental efficiency.

  11. 75 FR 16507 - In the Matter of Certain Semiconductor Chips Having Synchronous Dynamic Random Access Memory...

    Science.gov (United States)

    2010-04-01

    ... COMMISSION In the Matter of Certain Semiconductor Chips Having Synchronous Dynamic Random Access Memory... certain semiconductor chips having synchronous dynamic random access memory controllers and products... section 337 by importing certain semiconductor chips having synchronous dynamic random access...

  12. 76 FR 79215 - Certain Semiconductor Chips With Dram Circuitry, and Modules and Products Containing Same...

    Science.gov (United States)

    2011-12-21

    ... COMMISSION Certain Semiconductor Chips With Dram Circuitry, and Modules and Products Containing Same... importation of certain semiconductor chips with DRAM circuitry, and modules and products containing same by... after importation of certain semiconductor chips with DRAM circuitry, and modules and...

  13. 75 FR 48815 - Medicaid Program and Children's Health Insurance Program (CHIP); Revisions to the Medicaid...

    Science.gov (United States)

    2010-08-11

    ... Medicaid Program and Children's Health Insurance Program (CHIP); Revisions to the Medicaid Eligibility... Program and Children's Health Insurance Program (CHIP); Revisions to the Medicaid Eligibility Quality... Children's Health Insurance Program (CHIP). DATES: Effective Date: These regulations are effective on...

  14. 75 FR 44989 - In the Matter of Certain Semiconductor Chips Having Synchronous Dynamic Random Access Memory...

    Science.gov (United States)

    2010-07-30

    ... Certain Semiconductor Chips Having Synchronous Dynamic Random Access Memory Controllers and Products... chips having synchronous dynamic random access memory controllers and product containing the same by... importing certain semiconductor chips having synchronous dynamic random access memory controllers and...

  15. A primary battery-on-a-chip using monolayer graphene

    Science.gov (United States)

    Iost, Rodrigo M.; Crespilho, Frank N.; Kern, Klaus; Balasubramanian, Kannan

    2016-07-01

    We present here a bottom-up approach for realizing on-chip on-demand batteries starting out with chemical vapor deposition-grown graphene. Single graphene monolayers contacted by electrode lines on a silicon chip serve as electrodes. The anode and cathode are realized by electrodeposition of zinc and copper respectively onto graphene, leading to the realization of a miniature graphene-based Daniell cell on a chip. The electrolyte is housed partly in a gel and partly in liquid form in an on-chip enclosure molded using a 3d printer or made out of poly(dimethylsiloxane). The realized batteries provide a stable voltage (∼1.1 V) for many hours and exhibit capacities as high as 15 μAh, providing enough power to operate a pocket calculator. The realized batteries show promise for deployment as on-chip power sources for autonomous systems in lab-on-a-chip or biomedical applications.

  16. Neural network chips for trigger purposes in high energy physics

    Energy Technology Data Exchange (ETDEWEB)

    Gemmeke, H.; Eppler, W.; Fischer, T. [Research Center Karlsruhe (Germany)] [and others

    1996-12-31

    Two novel neural chips SAND (Simple Applicable Neural Device) and SIOP (Serial Input - Operating Parallel) are described. Both are highly usable for hardware triggers in particle physics. The chips are optimized for a high input data rate at a very low cost basis. The performance of a single SAND chip is 200 MOPS due to four parallel 16 bit multipliers and 40 bit adders working in one clock cycle. The chip is able to implement feedforward neural networks, Kohonen feature maps and radial basis function networks. Four chips will be implemented on a PCI-board for simulation and on a VUE board for trigger and on- and off-line analysis. For small sized feedforward neural networks the bit-serial neuro-chip SIOP may lead to even smaller latencies because each synaptic connection is implemented by its own bit serial multiplier and adder.

  17. A fast template matching method for LED chip Localization

    Directory of Open Access Journals (Sweden)

    Zhong Fuqiang

    2015-01-01

    Full Text Available Efficiency determines the profits of the semiconductor producers. So the producers spare no effort to enhance the efficiency of every procedure. The purpose of the paper is to present a method to shorten the time to locate the LED chips on wafer. The method consists of 3 steps. Firstly, image segmentation and blob analyzation are used to predict the positions of potential chips. Then predict the orientations of potential chips based on their dominant orientations. Finally, according to the positions and orientations predicted above, locate the chips precisely based on gradient orientation features. Experiments show that the algorithm is faster than the traditional method we choose to locate the LED chips. Besides, even the orientations of the chips on wafer are of big deviation to the orientation of the template, the efficiency of this method won't be affected.

  18. Organ-on-a-chip and the kidney.

    Science.gov (United States)

    Kim, Sejoong; Takayama, Shuichi

    2015-09-01

    Traditional approaches to pathophysiology are advancing but still have many limitations that arise from real biologic systems and their associated physiological phenomena being too complicated. Microfluidics is a novel technology in the field of engineering, which provides new options that may overcome these hurdles. Microfluidics handles small volumes of fluids and may apply to various applications such as DNA analysis chips, other lab-on-a-chip analyses, micropropulsion, and microthermal technologies. Among them, organ-on-a-chip applications allow the fabrication of minimal functional units of a single organ or multiple organs. Relevant to the field of nephrology, renal tubular cells have been integrated with microfluidic devices for making kidneys-on-a-chip. Although still early in development, kidneys-on-a-chip are showing potential to provide a better understanding of the kidney to replace some traditional animal and human studies, particularly as more cell types are incorporated toward the development of a complete glomeruli-on-a-chip.

  19. Flip-chip light emitting diode with resonant optical microcavity

    Science.gov (United States)

    Gee, James M.; Bogart, Katherine H.A.; Fischer, Arthur J.

    2005-11-29

    A flip-chip light emitting diode with enhanced efficiency. The device structure employs a microcavity structure in a flip-chip configuration. The microcavity enhances the light emission in vertical modes, which are readily extracted from the device. Most of the rest of the light is emitted into waveguided lateral modes. Flip-chip configuration is advantageous for light emitting diodes (LEDs) grown on dielectric substrates (e.g., gallium nitride LEDs grown on sapphire substrates) in general due to better thermal dissipation and lower series resistance. Flip-chip configuration is advantageous for microcavity LEDs in particular because (a) one of the reflectors is a high-reflectivity metal ohmic contact that is already part of the flip-chip configuration, and (b) current conduction is only required through a single distributed Bragg reflector. Some of the waveguided lateral modes can also be extracted with angled sidewalls used for the interdigitated contacts in the flip-chip configuration.

  20. Application of Ferrite Nanomaterial in RF On-Chip Inductors

    Directory of Open Access Journals (Sweden)

    Hua-Lin Cai

    2013-01-01

    Full Text Available Several kinds of ferrite-integrated on-chip inductors are presented. Ferrite nanomaterial applied in RF on-chip inductors is prepared and analyzed to show the properties of high permeability, high ferromagnetic resonance frequency, high resistivity, and low loss, which has the potential that will improve the performance of RF on-chip inductors. Simulations of different coil and ferrite nanomaterial parameters, inductor structures, and surrounding structures are also conducted to achieve the trend of gains of inductance and quality factor of on-chip inductors. By integrating the prepared ferrite magnetic nanomaterial to the on-chip inductors with different structures, the measurement performances show an obvious improvement even in GHz frequency range. In addition, the studies of CMOS compatible process to integrate the nanomaterial promote the widespread application of magnetic nanomaterial in RF on-chip inductors.

  1. Atom chip based generation of entanglement for quantum metrology

    CERN Document Server

    Riedel, Max F; Li, Yun; Hänsch, Theodor W; Sinatra, Alice; Treutlein, Philipp

    2010-01-01

    Atom chips provide a versatile `quantum laboratory on a microchip' for experiments with ultracold atomic gases. They have been used in experiments on diverse topics such as low-dimensional quantum gases, cavity quantum electrodynamics, atom-surface interactions, and chip-based atomic clocks and interferometers. A severe limitation of atom chips, however, is that techniques to control atomic interactions and to generate entanglement have not been experimentally available so far. Such techniques enable chip-based studies of entangled many-body systems and are a key prerequisite for atom chip applications in quantum simulations, quantum information processing, and quantum metrology. Here we report experiments where we generate multi-particle entanglement on an atom chip by controlling elastic collisional interactions with a state-dependent potential. We employ this technique to generate spin-squeezed states of a two-component Bose-Einstein condensate and show that they are useful for quantum metrology. The obser...

  2. Improving chip-to-chip precision in disposable microchip capillary electrophoresis devices with internal standards.

    Science.gov (United States)

    Bidulock, Allison C E; van den Berg, Albert; Eijkel, Jan C T

    2015-03-01

    To realize portable systems for routine measurements in point-of-care settings, MCE methods are required to be robust across many single-use chips. While it is well-known internal standards (ISTDs) improve run-to-run precision, a systematic investigation is necessary to determine the significance of chip-to-chip imprecision in MCE and how ISTDs account for it. This paper addresses this question by exploring the reproducibility of Na quantification across six basic, in-house fabricated microchips. A dataset of 900 electrophoerograms was collected from analyzing five concentrations of NaCl with two ISTDs (CsCl and LiCl). While both improved the peak area reproducibility, the Na/Cs ratio was superior to the Na/Li ratio (improving the RSD by a factor of 2-4, depending on the Na concentration). We attribute this to the significant variation in microchannel surface properties, which was accounted for by cesium but not lithium. Microchip dimension and detector variations were only a few percent, and could be improved through commercial fabrication over in-house made microchips. These results demonstrate that ISTDs not only correct for intrachip imprecision, but are also a viable means to correct for chip-to-chip imprecision inherent in disposable, point-of-care MCE devices. However, as expected, the internal standard must be carefully chosen.

  3. Photonic Wire Bonds for Terabit/s Chip-to-Chip Interconnects

    CERN Document Server

    Lindenmann, Nicole; Hillerkuss, David; Schmogrow, Rene; Jordan, Meinert; Leuthold, Juerg; Freude, Wolfgang; Koos, Christian

    2011-01-01

    Photonic integration has witnessed tremendous progress over the last years, and chip-scale transceiver systems with Terabit/s data rates have come into reach. However, as on-chip integration density increases, efficient off-chip interfaces are becoming more and more crucial. A technological breakthrough is considered indispensable to cope with the challenges arising from large-scale photonic integration, and this particularly applies to short-distance optical interconnects. In this letter we introduce the concept of photonic wire bonding, where transparent waveguide wire bonds are used to bridge the gap between nanophotonic circuits located on different chips. We demonstrate for the first time the fabrication of three-dimensional freeform photonic wire bonds (PWB), and we confirm their viability in a multi-Terabit/s data transmission experiment. First-generation prototypes allow for efficient broadband coupling with overall losses of only 1.6 dB. Photonic wire bonding will enable flexible optical multi-chip a...

  4. Large Chip Production Mechanism under the Extreme Load Cutting Conditions

    Institute of Scientific and Technical Information of China (English)

    LIU Xianli; HE Genghuang; YAN Fugang; CHENG Yaonan; LIU Li

    2015-01-01

    There has existed a great deal of theory researches in term of chip production and chip breaking characteristics under conventional cutting and high speed cutting conditions, however, there isn’t sufficient research on chip formation mechanism as well as its influence on cutting state regarding large workpieces under extreme load cutting. This paper presents a model of large saw-tooth chip through applying finite element simulation method, which gives a profound analysis about the characteristics of the extreme load cutting as well as morphology and removal of the large chip. In the meantime, a calculation formula that gives a quantitative description of the saw-tooth level regarding the large chip is established on the basis of cutting experiments on high temperature and high strength steel 2.25Cr-1Mo-0.25V. The cutting experiments are carried out by using the scanning electron microscope and super depth of field electron microscope to measure and calculate the large chip produced under different cutting parameters, which can verify the validity of the established model. The calculating results show that the large saw-toothed chip is produced under the squeezing action between workpiece and cutting tools. In the meanwhile, the chip develops a hardened layer where contacts the cutting tool and the saw-tooth of the chip tend to form in transverse direction. This research creates the theoretical model for large chip and performs the cutting experiments under the extreme load cutting condition, as well as analyzes the production mechanism of the large chip in the macro and micro conditions. Therefore, the proposed research could provide theoretical guidance and technical support in improving productivity and cutting technology research.

  5. Technology for melting amber chips to produce a solid block

    Science.gov (United States)

    Vikhareva, A. S.; Melnikov, A. G.; Utyev, O. M.

    2016-04-01

    This research is relevant, because the bulk of the mined amber comes in amber chips. Therefore, we have decided to review the current ways of melting amber chips to develop the most technologically efficient algorithm and to use it further for producing decorative items. The purpose of the work is to perfect the technology of obtaining whole-piece amber from amber chips and to explore the usability of the obtained material in decorative items and jewelry.

  6. A Modular Programmable CMOS Analog Fuzzy Controller Chip

    OpenAIRE

    1999-01-01

    We present a highly modular fuzzy inference analog CMOS chip architecture with on-chip digital programmability. This chip consists of the interconnection of parameterized instances of two different kind of blocks, namely label blocks and rule blocks. The architecture realizes a lattice partition of the universe of discourse, which at the hardware level means that the fuzzy labels associated to every input (realized by the label blocks) are shared among the rule blocks. This reduces the area a...

  7. DFT Techniques in DSP Chip Core NDSP25

    Institute of Scientific and Technical Information of China (English)

    XUE Jing; BAI Yong-qiang; DENG Zheng-hong; ZHENG Wei

    2004-01-01

    Design for Testability(DFT) is critical in chip design.DFT techniques insert hardware logic to an original design,in order to improve testability of the chip,and thus reduce test cost significantly.In this paper,we introduces the most frequently used DFT techniques,then put emphasis on the DFT policy and the DFT realization of the NDSP25 chip core,and analyses the result at last.

  8. Polystyrene Based SPR Biosensor Chip for Use in Immunoassay

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    Biosensors are widely used in immunoassay.The biosensor chip carries a receptor which is used in immunoassay and the chip properties have an important influence on the detecting sensitivity of the biosensor.This paper describes a polystyrene-based biosensor chip developed and used as part of a surface plasmon resonance (SPR) biosensor.The SPR biosensor has a much higher detecting sensitivity than enzyme-linked immunoserbent assay (ELISA).

  9. Analysis and Management of Communication in On-Chip Networks

    OpenAIRE

    Jafari, Fahimeh

    2015-01-01

    Regarding the needs of low-power, high-performance embedded systems and the growing computation-intensive applications, the number of computing resources in a single chip has enormously increased. The current VLSI technology is able to support such an integration of transistors and add many computing resources such as CPU, DSP, specific IPs, etc to build a Systemon- Chip (SoC). However, interconnection between resources becomes another challenging issue which can be raised by using an on-chip...

  10. Lithographic chip identification: meeting the failure analysis challenge

    Science.gov (United States)

    Perkins, Lynn; Riddell, Kevin G.; Flack, Warren W.

    1992-06-01

    This paper describes a novel method using stepper photolithography to uniquely identify individual chips for permanent traceability. A commercially available 1X stepper is used to mark chips with an identifier or `serial number' which can be encoded with relevant information for the integrated circuit manufacturer. The permanent identification of individual chips can improve current methods of quality control, failure analysis, and inventory control. The need for this technology is escalating as manufacturers seek to provide six sigma quality control for their products and trace fabrication problems to their source. This need is especially acute for parts that fail after packaging and are returned to the manufacturer for analysis. Using this novel approach, failure analysis data can be tied back to a particular batch, wafer, or even a position within a wafer. Process control can be enhanced by identifying the root cause of chip failures. Chip identification also addresses manufacturers concerns with increasing incidences of chip theft. Since chips currently carry no identification other than the manufacturer's name and part number, recovery efforts are hampered by the inability to determine the sales history of a specific packaged chip. A definitive identifier or serial number for each chip would address this concern. The results of chip identification (patent pending) are easily viewed through a low power microscope. Batch number, wafer number, exposure step, and chip location within the exposure step can be recorded, as can dates and other items of interest. An explanation of the chip identification procedure and processing requirements are described. Experimental testing and results are presented, and potential applications are discussed.

  11. High-Resolution, Low-Cost Spectrometer-on-Chip

    Science.gov (United States)

    2015-01-02

    increase the performance of the devices. All the prototype chips were made using Electron Beam Lithography ( EBL ) and reactive ion etching (RIE). Specific...the input coupling efficiency when using inverted tapers. In total, more than 50 designs were fabricated by EBL and plasma etching in order to...performance (DPH reflectivity, channel numbers, etc…) of the imprinted chips are very close to the ones made by EBL . Around 100 chips were

  12. Assessment of the relationship between pre-chip and post-chip quality measures for Affymetrix GeneChip expression data

    Directory of Open Access Journals (Sweden)

    Augood Sarah J

    2006-04-01

    Full Text Available Abstract Background Gene expression microarray experiments are expensive to conduct and guidelines for acceptable quality control at intermediate steps before and after the samples are hybridised to chips are vague. We conducted an experiment hybridising RNA from human brain to 117 U133A Affymetrix GeneChips and used these data to explore the relationship between 4 pre-chip variables and 22 post-chip outcomes and quality control measures. Results We found that the pre-chip variables were significantly correlated with each other but that this correlation was strongest between measures of RNA quality and cRNA yield. Post-mortem interval was negatively correlated with these variables. Four principal components, reflecting array outliers, array adjustment, hybridisation noise and RNA integrity, explain about 75% of the total post-chip measure variability. Two significant canonical correlations existed between the pre-chip and post-chip variables, derived from MAS 5.0, dChip and the Bioconductor packages affy and affyPLM. The strongest (CANCOR 0.838, p Conclusion We have found that the post-chip variables having the strongest association with quantities measurable before hybridisation are those reflecting RNA integrity. Other aspects of quality, such as noise measures (reflecting the execution of the assay or measures reflecting data quality (outlier status and array adjustment variables are not well predicted by the variables we were able to determine ahead of time. There could be other variables measurable pre-hybridisation which may be better associated with expression data quality measures. Uncovering such connections could create savings on costly microarray experiments by eliminating poor samples before hybridisation.

  13. Low-power chip-level optical interconnects based on bulk-silicon single-chip photonic transceivers

    Science.gov (United States)

    Kim, Gyungock; Park, Hyundai; Joo, Jiho; Jang, Ki-Seok; Kwack, Myung-Joon; Kim, Sanghoon; Kim, In Gyoo; Kim, Sun Ae; Oh, Jin Hyuk; Park, Jaegyu; Kim, Sanggi

    2016-03-01

    We present new scheme for chip-level photonic I/Os, based on monolithically integrated vertical photonic devices on bulk silicon, which increases the integration level of PICs to a complete photonic transceiver (TRx) including chip-level light source. A prototype of the single-chip photonic TRx based on a bulk silicon substrate demonstrated 20 Gb/s low power chip-level optical interconnects between fabricated chips, proving that this scheme can offer compact low-cost chip-level I/O solutions and have a significant impact on practical electronic-photonic integration in high performance computers (HPC), cpu-memory interface, 3D-IC, and LAN/SAN/data-center and network applications.

  14. ANALYTICAL CHIP FORMATION MODEL OF MICRO-END-MILLING

    Institute of Scientific and Technical Information of China (English)

    LI Chengfeng; LAI Xinmin; LI Hongtao; PENG Linfa; NI Jun

    2008-01-01

    A new analytical chip formation model is proposed for micro-end-milling operations. The model calculates an instantaneous uncut chip thickness by considering the combination of exact trochoidal trajectory of the tool tip and tool run-out, while the simplified circular trajectory and the neglected run-out create negligible change in conventional-scale chip formation models. Newton-Raphson iterative method is employed during the calculation to obtain quadratic convergence. The proposed approach allows the calculation of instantaneous uncut chip thickness to be done accurately and rapidly, and the prediction accuracy of this model is also verified by comparing the simulation results to experimental cutting forces.

  15. Numerical Simulation of Chip Formation in Metal Cutting Process

    Directory of Open Access Journals (Sweden)

    HUANG Meixia

    2012-07-01

    Full Text Available In order to study the chip formation mechanism in metal cutting process, based on finite element software ABAQUS, establish finite element model, and carry out numerical simulation on serrated chip formation of Ni-base superalloy GH4169 and ribbon chip formation of 45# steel respectively.In addition, analyze the influence law of three factors (cutting speed, feed rate, back cutting depth on cutting force and the distribution rule of cutting heat in serrated chip formation of GH4169.  

  16. Integrated polymerase chain reaction chips utilizing digital microfluidics.

    Science.gov (United States)

    Chang, Yi-Hsien; Lee, Gwo-Bin; Huang, Fu-Chun; Chen, Yi-Yu; Lin, Jr-Lung

    2006-09-01

    This study reports an integrated microfluidic chip for polymerase chain reaction (PCR) applications utilizing digital microfluidic chip (DMC) technology. Several crucial procedures including sample transportation, mixing, and DNA amplification were performed on the integrated chip using electro-wetting-on-dielectric (EWOD) effect. An innovative concept of hydrophobic/hydrophilic structure has been successfully demonstrated to integrate the DMC chip with the on-chip PCR device. Sample droplets were generated, transported and mixed by the EWOD-actuation. Then the mixture droplets were transported to a PCR chamber by utilizing the hydrophilic/hydrophobic interface to generate required surface tension gradient. A micro temperature sensor and two micro heaters inside the PCR chamber along with a controller were used to form a micro temperature control module, which could perform precise PCR thermal cycling for DNA amplification. In order to demonstrate the performance of the integrated DMC/PCR chips, a detection gene for Dengue II virus was successfully amplified and detected. The new integrated DMC/PCR chips only required an operation voltage of 12V(RMS) at a frequency of 3 KHz for digital microfluidic actuation and 9V(DC) for thermal cycling. When compared to its large-scale counterparts for DNA amplification, the developed system consumed less sample and reagent and could reduce the detection time. The developed chips successfully demonstrated the feasibility of Lab-On-a-Chip (LOC) by utilizing EWOD-based digital microfluidics.

  17. Real time image processing with an analog vision chip system.

    Science.gov (United States)

    Kameda, S; Honda, A; Yagi, T

    1999-10-01

    A linear analog network model is proposed to characterize the function of the outer retinal circuit in terms of the standard regularization theory. Inspired by the function and the architecture of the model, a vision chip has been designed using analog CMOS Very Large Scale Integrated circuit technology. In the chip, sample/hold amplifier circuits are incorporated to compensate for statistic transistor mismatches. Accordingly, extremely low noise outputs were obtained from the chip. Using the chip and a zero-crossing detector, edges of given images were effectively extracted in indoor illumination.

  18. Efficiency of forest chip transportation from Russian Karelia to Finland

    Energy Technology Data Exchange (ETDEWEB)

    Goltsev, V.; Trishkin, M.; Tolonen, T.

    2011-07-01

    Nowadays the development of bioenergy in Russian Karelia is hindered by various factors. However, the development of modern cut-to-length harvesting techniques, available wood resources and Russian customs policy have created opportunities to export forest chips from Russian Karelia to Finland. An important factor for the export is the total supply cost of Russian forest chips to Finland. This depends to a large degree on the costs of transportation of the forest chips. In this study the efficiency and costs of cross-border transportation of forest chips were analysed and compared with the efficiency and costs of transportation of forest chips of Finnish origin. Data collected from various companies involved in forest chip production and their supply from Russia to Finland were used to calculate the costs of cross-border transportation of forest chips and to estimate the average productivity of chip trucks delivering from Russia to Finland. These outputs were compared with the transportation costs and productivity of chip trucks within Finland and Russia. Truck drivers involved in cross-border transportation of forest chips were also interviewed to determine factors affecting the efficiency of forest chips transportation. In addition, the quality characteristics of the Russian forest chips being supplied to Finland were analysed. Analysis of transportation costs showed that the highest costs for the 80 km reference distance are those within Finland - 4.7 euro/loose m3, the costs on the cross-border route studied, from Lendery (Republic of Karelia) to Lieksa (Finland) through the Inari border crossing point, are 3.4 euro/loose m3 and transportation costs within Russia are 3.5 euro/loose m3. Transportation costs as a proportion of the total supply costs were highest for forest chips imported from Russia at 26%, whereas in Finland and Russia they were 23% and 19% respectively. According to the results of the interviews, bad road conditions and idle time on the border

  19. HPV 9G DNA Chip: 100% Clinical Sensitivity and Specificity

    OpenAIRE

    An, Heejung; Song, Keum-Soo; Nimse, Satish Balasaheb; Kim, Junghoon; Nguyen, Van-Thuan; Ta, Van-Thao; Sayyed, Danishmalik Rafiq; Kim, Taisun

    2012-01-01

    We describe a novel HPV 9G DNA chip test for the accurate and reliable genotyping of human papillomavirus (HPV). The HPV 9G DNA chip test established its efficiency in terms of a signal-to-background ratio (SBR) of 200, which is 50 times superior to commercial HPV DNA chips, and 100% target-specific hybridization at 25°C. We compared the genotyping results for the 439 clinical samples by the HPV 9G DNA chip test with the sequencing results for the MY11/GP6+ (M2) primer set-mediated PCR produc...

  20. Integrated lasers for polymer Lab-on-a-Chip systems

    DEFF Research Database (Denmark)

    Mappes, Timo; Vannahme, Christoph; Grosmann, Tobias

    2012-01-01

    We develop optical Lab-on-a-Chips on different platforms for marker-based and label-free biophotonic sensor applications. Our chips are based on polymers and fabricated by mass production technologies to integrate microfluidic channels, optical waveguides and miniaturized lasers.......We develop optical Lab-on-a-Chips on different platforms for marker-based and label-free biophotonic sensor applications. Our chips are based on polymers and fabricated by mass production technologies to integrate microfluidic channels, optical waveguides and miniaturized lasers....

  1. PERFORMANCE EVALUATION OF A LOCALLY DEVELOPED CASSAVA CHIPPING MACHINE

    Directory of Open Access Journals (Sweden)

    B. O. Bolaji

    2012-01-01

    Full Text Available

    ENGLISH ABSTRACT: A cassava chipping machine was designed and constructed, and its performance evaluated. The results showed that motor speed has significant effects on chipping capacity, chipping efficiency, and chips geometry. The higher the motor speed, the higher the chipping capacity and the lower the chipping efficiency of the machine. The machine has a maximum capacity of 245 kgh–1 at 500 rpm, and maximum chipping efficiency of 92.6% at a speed of 300 rpm. The overall best performance of the machine is obtained at a speed of 400 rpm with chipping efficiency of 86.5% and chipping capacity of 240 kgh–1.

    AFRIKAANSE OPSOMMING: Die vertoning van ‘n prototype spaandermasjien is bepaal na ontwerp en vervaardiging. Die resultate toon dat motorsnelheid ‘n betekenisvolle invloed het op spaanderuitset, spaanderrendement en spaandervorm. Hoër snelheid verhoog die spaanderuitset, maar tegelyke tyd verlaag die prosesrendement. Die maksimum prosesuitset is 245 kilogram per uur teen 500 omwentelinge per minuut. In den breede is die beste vertoning by 40 omwentelinge per minuut by ‘n rendement van 86.5% en ‘n uitset van 240 kilogram per uur.

  2. Viral diagnosis in Indian livestock using customized microarray chips.

    Science.gov (United States)

    Yadav, Brijesh S; Pokhriyal, Mayank; Ratta, Barkha; Kumar, Ajay; Saxena, Meeta; Sharma, Bhaskar

    2015-01-01

    Viral diagnosis in Indian livestock using customized microarray chips is gaining momentum in recent years. Hence, it is possible to design customized microarray chip for viruses infecting livestock in India. Customized microarray chips identified Bovine herpes virus-1 (BHV-1), Canine Adeno Virus-1 (CAV-1), and Canine Parvo Virus-2 (CPV-2) in clinical samples. Microarray identified specific probes were further confirmed using RT-PCR in all clinical and known samples. Therefore, the application of microarray chips during viral disease outbreaks in Indian livestock is possible where conventional methods are unsuitable. It should be noted that customized application requires a detailed cost efficiency calculation.

  3. Mechanically Flexible Active Silicon Chips and Systems Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Using innovative chip thinning technology married with recently available packaging technology, this effort will produce Mechanically Flexible Multifunctional Active...

  4. The drying of wood chips with surplus heat in Norway

    Energy Technology Data Exchange (ETDEWEB)

    Nordhagen, E. [Norwegian Forest and Landscape Inst., As (Norway). Dept. of Forest Resources, Forest Operations and Economics

    2010-07-01

    The study evaluated a wood chip drying procedure that used surplus heat from 2 hydroelectric power plants in western Norway. The wood was chipped and then loaded into the dryer using a tractor-trailer and a container. Warm air from the plants was funnelled into the dryer from perforated floors in the plants and an electric fan. Trials of the procedure were conducted to determine the drying capacity of the trailer and container. The study showed that the temperature and the moisture content of the wood chips varied over the course of the drying period. The chips located at the bottom dried first. The moisture content in the chip ranged between 66.1 to 52.1 before drying and between 9.6 and 6.9 per cent after drying. No substantial difference in moisture content between wood chips located at the top and bottom of the piles was noted. The net calorific values of the wood chips ranged from 1340 to 2170 kWh per tonne before drying, and between 4710 to 4860 after drying. The study showed that the cheapest option for the production of wood chips is natural drying and chipping at the roadside.

  5. Technology Roadmap: Lab-on-a-Chip

    Directory of Open Access Journals (Sweden)

    Pattharaporn Suntharasaj

    2010-04-01

    Full Text Available With the integration of microfluidic and MEMS technologies, biochips such as the lab-on-a-chip (LOC devices are at the brink of revolutionizing the medical disease diagnostics industries. Remarkable advancements in the biochips industry are making products resembling Star Trek.s "tricorder" and handheld medical scanners a reality. Soon, doctors can screen for cancer at the molecular level without costly and cumbersome equipments, and discuss treatment plans based on immediate lab results. This paper develops a roadmap for a hypothetical company (XI which is seeking to be successful in this market. The roadmapping process starts with gathering data through literature research and expert opinions, and progress through defining the market/product/technology layers, linking and integrating these layers, and finally creating a labon-a-chip for disease diagnostics technology roadmap.

  6. On-Chip Single-Photon Sifter

    CERN Document Server

    Elshaari, Ali W; Fognini, Andreas; Reimer, Michael E; Dalacu, Dan; Poole, Philip J; Zwiller, Val; Jöns, Klaus D

    2016-01-01

    Quantum states of light play a pivotal role in modern science[1] and future photonic applications[2]. While impressive progress has been made in their generation and manipulation with high fidelities, the common table-top approach is reaching its limits for practical quantum applications. Since the advent of integrated quantum nanophotonics[3] different material platforms based on III-V nanostructures-, color centers-, and nonlinear waveguides[4-8] as on-chip light sources have been investigated. Each platform has unique advantages and limitations in terms of source properties, optical circuit complexity, and scaling potentials. However, all implementations face major challenges with efficient and tunable filtering of individual quantum states[4], scalable integration and deterministic multiplexing of on-demand selected quantum emitters[9], and on-chip excitation-suppression[10]. Here we overcome all of these challenges with a novel hybrid and scalable nanofabrication approach to generate quantum light on-chi...

  7. Fabrication of Microfluidic Fiber Chip Detection System

    Institute of Scientific and Technical Information of China (English)

    Bo Su; Da-fu Cui; Chang-chun Liu; Xing Chen

    2006-01-01

    The diameter of the excitation beam was decreased greatly by integrating the fiber on the microfluidic chip as light propagation medium. The coupling efficiency of the fiber was improved with optical fiber collimation device coupling beam.The chip was placed in the darkroom to avoid the interference of the external light. The cost of the instrument was decreased with a high brightness blue LED as excitation source; the performance of the system was valuated by the determination of FITC fluorescein with a minimum detectable concentration of 2.2×10-8 mol/L, the Signal-to-Noise Ratio (SNR) S/N=5. The correlation coefficient of the detection system within the range of 1.8 × 10-7 mol/L~ 4 × 10-5mol/L was 0.9972.

  8. On-Chip Microwave Quantum Hall Circulator

    Science.gov (United States)

    Mahoney, A. C.; Colless, J. I.; Pauka, S. J.; Hornibrook, J. M.; Watson, J. D.; Gardner, G. C.; Manfra, M. J.; Doherty, A. C.; Reilly, D. J.

    2017-01-01

    Circulators are nonreciprocal circuit elements that are integral to technologies including radar systems, microwave communication transceivers, and the readout of quantum information devices. Their nonreciprocity arises from the interference of microwaves over the centimeter scale of the signal wavelength, in the presence of bulky magnetic media that breaks time-reversal symmetry. Here, we realize a completely passive on-chip microwave circulator with size 1 /1000 th the wavelength by exploiting the chiral, "slow-light" response of a two-dimensional electron gas in the quantum Hall regime. For an integrated GaAs device with 330 μ m diameter and about 1-GHz center frequency, a nonreciprocity of 25 dB is observed over a 50-MHz bandwidth. Furthermore, the nonreciprocity can be dynamically tuned by varying the voltage at the port, an aspect that may enable reconfigurable passive routing of microwave signals on chip.

  9. Chip-based quantum key distribution

    Science.gov (United States)

    Sibson, P.; Erven, C.; Godfrey, M.; Miki, S.; Yamashita, T.; Fujiwara, M.; Sasaki, M.; Terai, H.; Tanner, M. G.; Natarajan, C. M.; Hadfield, R. H.; O'Brien, J. L.; Thompson, M. G.

    2017-01-01

    Improvement in secure transmission of information is an urgent need for governments, corporations and individuals. Quantum key distribution (QKD) promises security based on the laws of physics and has rapidly grown from proof-of-concept to robust demonstrations and deployment of commercial systems. Despite these advances, QKD has not been widely adopted, and large-scale deployment will likely require chip-based devices for improved performance, miniaturization and enhanced functionality. Here we report low error rate, GHz clocked QKD operation of an indium phosphide transmitter chip and a silicon oxynitride receiver chip—monolithically integrated devices using components and manufacturing processes from the telecommunications industry. We use the reconfigurability of these devices to demonstrate three prominent QKD protocols—BB84, Coherent One Way and Differential Phase Shift—with performance comparable to state-of-the-art. These devices, when combined with integrated single photon detectors, pave the way for successfully integrating QKD into future telecommunications networks. PMID:28181489

  10. Invisibility Cloak Printed on a Photonic Chip

    Science.gov (United States)

    Feng, Zhen; Wu, Bing-Hong; Zhao, Yu-Xi; Gao, Jun; Qiao, Lu-Feng; Yang, Ai-Lin; Lin, Xiao-Feng; Jin, Xian-Min

    2016-01-01

    Invisibility cloak capable of hiding an object can be achieved by properly manipulating electromagnetic field. Such a remarkable ability has been shown in transformation and ray optics. Alternatively, it may be realistic to create a spatial cloak by means of confining electromagnetic field in three-dimensional arrayed waveguides and introducing appropriate collective curvature surrounding an object. We realize the artificial structure in borosilicate by femtosecond laser direct writing, where we prototype up to 5,000 waveguides to conceal millimeter-scale volume. We characterize the performance of the cloak by normalized cross correlation, tomography analysis and continuous three-dimensional viewing angle scan. Our results show invisibility cloak can be achieved in waveguide optics. Furthermore, directly printed invisibility cloak on a photonic chip may enable controllable study and novel applications in classical and quantum integrated photonics, such as invisualising a coupling or swapping operation with on-chip circuits of their own. PMID:27329510

  11. On-chip tunable optofluidic dye laser

    Science.gov (United States)

    Cai, Zengyan; Shen, Zhenhua; Liu, Haigang; Yue, Huan; Zou, Yun; Chen, Xianfeng

    2016-11-01

    We demonstrate a chip-scale tunable optofluidic dye laser with Au-coated fibers as microcavity. The chip is fabricated by soft lithography. When the active region is pumped, a relatively low threshold of 6.7 μJ/mm2 is realized with multimode emission due to good confinement of the cavity mirrors, long active region, as well as total reflectivity. It is easy to tune the lasing emission wavelength by changing the solvent of laser dye. In addition, the various intensity ratios of multicolor lasing can be achieved by controlling flow rates of two fluid streams carried with different dye molecules. Furthermore, the convenience in fabrication and directional lasing emission outcoupled by the fiber make the tunable optofluidic dye laser a promising underlying coherent light source in the integrated optofluidic systems.

  12. On-chip plasmonic waveguide optical waveplate

    Science.gov (United States)

    Gao, Linfei; Huo, Yijie; Zang, Kai; Paik, Seonghyun; Chen, Yusi; Harris, James S.; Zhou, Zhiping

    2015-10-01

    Polarization manipulation is essential in almost every photonic system ranging from telecommunications to bio-sensing to quantum information. This is traditionally achieved using bulk waveplates. With the developing trend of photonic systems towards integration and miniaturization, the need for an on-chip waveguide type waveplate becomes extremely urgent. However, this is very challenging using conventional dielectric waveguides, which usually require complex 3D geometries to alter the waveguide symmetry and are also difficult to create an arbitrary optical axis. Recently, a waveguide waveplate was realized using femtosecond laser writing, but the device length is in millimeter range. Here, for the first time we propose and experimentally demonstrate an ultracompact, on-chip waveplate using an asymmetric hybrid plasmonic waveguide to create an arbitrary optical axis. The device is only in several microns length and produced in a flexible integratable IC compatible format, thus opening up the potential for integration into a broad range of systems.

  13. Microengineered physiological biomimicry: organs-on-chips.

    Science.gov (United States)

    Huh, Dongeun; Torisawa, Yu-suke; Hamilton, Geraldine A; Kim, Hyun Jung; Ingber, Donald E

    2012-06-21

    Microscale engineering technologies provide unprecedented opportunities to create cell culture microenvironments that go beyond current three-dimensional in vitro models by recapitulating the critical tissue-tissue interfaces, spatiotemporal chemical gradients, and dynamic mechanical microenvironments of living organs. Here we review recent advances in this field made over the past two years that are focused on the development of 'Organs-on-Chips' in which living cells are cultured within microfluidic devices that have been microengineered to reconstitute tissue arrangements observed in living organs in order to study physiology in an organ-specific context and to develop specialized in vitro disease models. We discuss the potential of organs-on-chips as alternatives to conventional cell culture models and animal testing for pharmaceutical and toxicology applications. We also explore challenges that lie ahead if this field is to fulfil its promise to transform the future of drug development and chemical safety testing.

  14. Surface enhanced raman spectroscopy on chip

    DEFF Research Database (Denmark)

    Hübner, Jörg; Anhøj, Thomas Aarøe; Zauner, Dan

    2007-01-01

    In this paper we report low resolution surface enhanced Raman spectra (SERS) conducted with a chip based spectrometer. The flat field spectrometer presented here is fabricated in SU-8 on silicon, showing a resolution of around 3 nm and a free spectral range of around 100 nm. The output facet...... is projected onto a CCD element and visualized by a computer. To enhance the otherwise rather weak Raman signal, a nanosurface is prepared and a sample solutions is impregnated on this surface. The surface enhanced Raman signal is picked up using a Raman probe and coupled into the spectrometer via an optical...... fiber. The obtained spectra show that chip based spectrometer together with the SERS active surface can be used as Raman sensor....

  15. An Evaluation of an Integrated On-Chip/Off-Chip Network for High-Performance Reconfigurable Computing

    OpenAIRE

    Andrew G. Schmidt; Kritikos, William V.; Shanyuan Gao; Ron Sass

    2012-01-01

    As the number of cores per discrete integrated circuit (IC) device grows, the importance of the network on chip (NoC) increases. However, the body of research in this area has focused on discrete IC devices alone which may or may not serve the high-performance computing community which needs to assemble many of these devices into very large scale, parallel computing machines. This paper describes an integrated on-chip/off-chip network that has been implemented on an a...

  16. Fiber optic to integrated optical chip coupler

    Science.gov (United States)

    Pikulski, Joseph I. (Inventor); Ramer, O. Glenn (Inventor)

    1987-01-01

    Optical fibers are clamped by a block onto a substrate. Thereupon, metal is plated over the fibers to hold them in place upon the substrate. The clamp block is removed and the opening, resulting from the clamp block's presence, is then plated in. The built-up metallic body is a coupling which holds the fibers in position so that the ends can be polished for coupling to an integrated optical chip upon a coupling fixture.

  17. Silicon-Chip-Based Optical Frequency Combs

    Science.gov (United States)

    2015-10-26

    frequencies . This phenomenon appears in many systems spanning biology, chemistry, neuroscience, and physics [29,30]. Examples include power grid networks... Frequency Combs," Phys. Rev. Lett. 100, 013902 (2008). [91] F. Leo, et al., “Dispersive wave emission and supercontinuum generation in a silicon wire...AFRL-AFOSR-VA-TR-2015-0365 Silicon-Chip-Based Optical Frequency Combs Alexander Gaeta CORNELL UNIVERSITY Final Report 10/26/2015 DISTRIBUTION A

  18. Interleukin-6 Detection with a Plasmonic Chip

    Science.gov (United States)

    Tawa, Keiko; Sumiya, Masashi; Toma, Mana; Sasakawa, Chisato; Sujino, Takuma; Miyaki, Tatsuki; Nakazawa, Hikaru; Umetsu, Mitsuo

    Interleukin-6, a cytokine relating inflammatory and autoimmune activity, was detected with three fluorescence assays using a plasmonic chip. In their assays, the way of surface modification, sample volume, incubation time and mixing solution, were found to influence the detection sensitivity. When the assay was revised in the point of a rapid and easy process, the detection sensitivity was not compromised compared to assays with sufficient sample volume and assay time. To suit the purpose of immunosensing, the assay conditions should be determined.

  19. Generating Weighted Test Patterns for VLSI Chips

    Science.gov (United States)

    Siavoshi, Fardad

    1990-01-01

    Improved built-in self-testing circuitry for very-large-scale integrated (VLSI) digital circuits based on version of weighted-test-pattern-generation concept, in which ones and zeros in pseudorandom test patterns occur with probabilities weighted to enhance detection of certain kinds of faults. Requires fewer test patterns and less computation time and occupies less area on circuit chips. Easy to relate switching activity in outputs with fault-detection activity by use of probabilistic fault-detection techniques.

  20. Electrochemical mutagen screening using microbial chip.

    Science.gov (United States)

    Matsui, Nobuto; Kaya, Takatoshi; Nagamine, Kuniaki; Yasukawa, Tomoyuki; Shiku, Hitoshi; Matsue, Tomokazu

    2006-01-15

    Electrochemical microbial chip for mutagen screening were microfabricated and characterized by scanning electrochemical microscopy (SECM). Salmonella typhimurium TA1535 with a plasmid pSK1002 carrying a umuC'-'lacZ fusion gene was used for the whole cell mutagen sensor. The TA1535/pSK1002 cells were exposed to mutagen solutions containing 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamido (AF-2), mitomycin C (MMC) or 2-aminoanthracene (2-AA) and embedded in a microcavity (5nl) on a glass substrate using collagen gel. The beta-galactosidase expression on the microbial chip was electrochemically monitored using p-aminophenyl-beta-d-galactopyranoside (PAPG) as the enzymatic substrate. This system has several advantages compared with the conventional umu test: drastic reduction of the sample volume, less time-consuming for beta-galactosidase detection (free from substrate reaction time) and lower detection limit for the three mutagens (AF-2, MMC, 2-AA). Finally, a multi-sample assay was carried out using the microbial array chip with four microcavities.

  1. Routing algorithms in networks-on-chip

    CERN Document Server

    Daneshtalab, Masoud

    2014-01-01

    This book provides a single-source reference to routing algorithms for Networks-on-Chip (NoCs), as well as in-depth discussions of advanced solutions applied to current and next generation, many core NoC-based Systems-on-Chip (SoCs). After a basic introduction to the NoC design paradigm and architectures, routing algorithms for NoC architectures are presented and discussed at all abstraction levels, from the algorithmic level to actual implementation.  Coverage emphasizes the role played by the routing algorithm and is organized around key problems affecting current and next generation, many-core SoCs. A selection of routing algorithms is included, specifically designed to address key issues faced by designers in the ultra-deep sub-micron (UDSM) era, including performance improvement, power, energy, and thermal issues, fault tolerance and reliability.   ·         Provides a comprehensive overview of routing algorithms for Networks-on-Chip and NoC-based, manycore systems; ·         Describe...

  2. Chip breaking system for automated machine tool

    Science.gov (United States)

    Arehart, Theodore A.; Carey, Donald O.

    1987-01-01

    The invention is a rotary selectively directional valve assembly for use in an automated turret lathe for directing a stream of high pressure liquid machining coolant to the interface of a machine tool and workpiece for breaking up ribbon-shaped chips during the formation thereof so as to inhibit scratching or other marring of the machined surfaces by these ribbon-shaped chips. The valve assembly is provided by a manifold arrangement having a plurality of circumferentially spaced apart ports each coupled to a machine tool. The manifold is rotatable with the turret when the turret is positioned for alignment of a machine tool in a machining relationship with the workpiece. The manifold is connected to a non-rotational header having a single passageway therethrough which conveys the high pressure coolant to only the port in the manifold which is in registry with the tool disposed in a working relationship with the workpiece. To position the machine tools the turret is rotated and one of the tools is placed in a material-removing relationship of the workpiece. The passageway in the header and one of the ports in the manifold arrangement are then automatically aligned to supply the machining coolant to the machine tool workpiece interface for breaking up of the chips as well as cooling the tool and workpiece during the machining operation.

  3. A single chip with multiple talents

    CERN Multimedia

    Francesco Poppi

    2010-01-01

    The Medipix chips developed at CERN are being used in a variety of fields: from medicine to education and back to high-tech engineering. The scene is set for a bright future for this versatile technology.   The Medipix chip. It didn’t take long for a brilliant team of physicists and engineers who were working on pixel detectors for the LHC to realize that the technology had great potential in medical imaging. This was the birth of the Medipix project. Fifteen years later, with the collaboration of 18 research institutes, the team has produced an advanced version of the initial ideas: Medipix3 is a device that can measure very accurately the position and energy of the photons (one by one) that hit the associated detector. Radiography and computed tomography (CT) use X-ray photons to study the human body. The different energies of the photons in the beam can be thought of as the colours of the X-ray spectrum. This is why the use of Medipix3 chips in such diagnostic techniques is referred...

  4. Evaluation of Pressure Stable Chip-to-Tube Fittings Enabling High-Speed Chip-HPLC with Mass Spectrometric Detection.

    Science.gov (United States)

    Lotter, Carsten; Heiland, Josef J; Stein, Volkmar; Klimkait, Michael; Queisser, Marco; Belder, Detlev

    2016-08-01

    Appropriate chip-to-tube interfacing is an enabling technology for high-pressure and high-speed liquid chromatography on chip. For this purpose, various approaches, to connect pressure resistant glass chips with HPLC pumps working at pressures of up to 500 bar, were examined. Three side-port and one top-port connection approach were evaluated with regard to pressure stability and extra column band broadening. A clamp-based top-port approach enabled chip-HPLC-MS analysis of herbicides at the highest pressure and speed.

  5. Polydimethylsiloxane SlipChip for mammalian cell culture applications.

    Science.gov (United States)

    Chang, Chia-Wen; Peng, Chien-Chung; Liao, Wei-Hao; Tung, Yi-Chung

    2015-11-07

    This paper reports a polydimethylsiloxane (PDMS) SlipChip for in vitro cell culture applications, multiple-treatment assays, cell co-cultures, and cytokine detection assays. The PDMS SlipChip is composed of two PDMS layers with microfluidic channels on each surface that are separated by a thin silicone fluid (Si-fluid) layer. The integration of Si-fluid enables the two PDMS layers to be slid to different positions; therefore, the channel patterns can be re-arranged for various applications. The SlipChip design significantly reduces the complexity of sample handling, transportation, and treatment processes. To apply the developed SlipChip for cell culture applications, human lung adenocarcinoma epithelial cells (A549) and lung fibroblasts (MRC-5) were cultured to examine the biocompatibility of the developed PDMS SlipChip. Moreover, embryonic pluripotent stem cells (ES-D3) were also cultured in the device to evaluate the retention of their stemness in the device. The experimental results show that cell morphology, viability and proliferation are not affected when the cells are cultured in the SlipChip, indicating that the device is highly compatible with mammalian cell culture. In addition, the stemness of the ES-D3 cells was highly retained after they were cultured in the device, suggesting the feasibility of using the SlipChip for stem cell research. Various cell experiments, such as simultaneous triple staining of cells and co-culture of MRC-5 with A549 cells, were also performed to demonstrate the functionalities of the PDMS SlipChip. Furthermore, we used a cytokine detection assay to evaluate the effect of endotoxin (lipopolysaccharides, LPS) treatment on the cytokine secretion of A549 cells using the SlipChip. The developed PDMS SlipChip provides a straightforward and effective platform for various on-chip in vitro cell cultures and consequent analysis, which is promising for a number of cell biology studies and biomedical applications.

  6. Experiment list: SRX490475 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available eural cells NA 186808537,94.7,42.5,8682 GSM1346038: RNA Pol2 ChIP; Mus musculus; ChIP-Seq source_name=EB-Motor... neuron, WT, RNA Pol2 ChIP || strain/background=C57BL/6 || genotype/variation=wild type || cell type=EB-Motor

  7. Experiment list: SRX490477 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available cells NA 176672613,77.9,61.7,1277 GSM1346040: IgG ChIP; Mus musculus; ChIP-Seq source_name=EB-Motor neuron,... WT, IgG control ChIP || strain/background=C57BL/6 || genotype/variation=wild type || cell type=EB-Motor neu

  8. Experiment list: SRX113296 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ackie and Dow, 3rd ed.) 37365123,97.0,41.0,746 GSM851495: GRIP1-ChIP + LPS source_name=primary bone marrow-derived macrophages... || cell type=primary bone marrow-derived macrophages || strain...=C57BL/6 || chip antibody=GRIP1 || treatment=LPS-stimulated macrophages http://dbarchive.biosciencedbc.jp/ky

  9. Experiment list: SRX555489 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available sue=Embryo|Tissue Diagnosis=Normal 5370997,97.0,1.5,401 GSM1400761: ChIP HA; Homo sapiens; ChIP-Seq source_n...ame=Human Embryonic Stem Cells_HA || chip antibody=Pierce Anti-HA Agarose (Thermo Scientific, 26181) || cell

  10. Experiment list: SRX1041184 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available 48: anti-ATF4 (ABE387); Homo sapiens; ChIP-Seq source_name=HAP1, 2 mM histidinol for 24 hours, ATF4 ChIP || ...cell line=HAP1 || treatment=2 mM histidinol, 24 hours || chip antibody=ATF4 (Millipore, ABE387) http://dbarc

  11. Experiment list: SRX1041182 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available 46: anti-ATF4 (sc-200); Homo sapiens; ChIP-Seq source_name=HAP1, 2 mM histidinol for 24 hours, ATF4 ChIP || ...cell line=HAP1 || treatment=2 mM histidinol, 24 hours || chip antibody=ATF4 (Santa Cruz Biotechnology sc-200

  12. Experiment list: SRX1041183 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available 7: anti-ATF4 (D4B8); Homo sapiens; ChIP-Seq source_name=HAP1, 2 mM histidinol for 24 hours, ATF4 ChIP || cel...l line=HAP1 || treatment=2 mM histidinol, 24 hours || chip antibody=ATF4 (Cell Signaling Technology, D4B8, C

  13. Experiment list: SRX047648 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available pe=Fibroblast 15537299,94.1,28.9,714 GSM686978: RXR CHIP-seq 4 hours source_name=Preadipocyte cell line || c...ell line=3T3-L1 preadipocyte cell line || differentiation stage=Early stage || time=4 hours || chip antibody

  14. Experiment list: SRX084582 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available nly)] || chip antibody supplier=gift from Igor Dawid http://dbarchive.bioscienced...ne || cell line=DRSC-S2 cell line || chip antibody=FSH_ID173 [raised against protein 4.1 (recognizes FSH-L o

  15. Experiment list: SRX747303 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available e=whole larvae || strain=JA1507 || Stage=L3 || genotype/variation=lin-35 mutant || chip antibody=anti-H3K4me3 || chip antibody suppli...er=Wako http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/

  16. Experiment list: SRX059238 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available 1 HTZ1 || chip antibody supplier=Julie Ahringer http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/eachData/bw/...01 HTZ1 N2 L3 3 source_name=whole body || tissue=whole body || strain=N2 || Stage=L3 || chip antibody=JA0000

  17. Experiment list: SRX747304 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available plier=Wako http://dbarchive.biosciencedbc.jp/kyushu-u/ce...ssue=whole larvae || strain=JA1507 || Stage=L3 || genotype/variation=lin-35 mutant || chip antibody=anti-H3K4me3 || chip antibody sup

  18. Experiment list: SRX059223 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available 91 H3 N2 L3 1 source_name=whole body || tissue=whole body || strain=N2 || Stage=L3 || chip antibody=AB1791_H3 || chip antibody suppli...er=Abcam http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/eachData/bw/SRX059223.bw h

  19. Experiment list: SRX059229 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available 3:144 || chip antibody supplier=Lake Placid Bio http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/eachData/bw/...3 144 N2 L3 2 source_name=whole body || tissue=whole body || strain=N2 || Stage=L3 || chip antibody=AR0144_H

  20. Experiment list: SRX062282 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available 8,84.0,33.9,6620 GSM722524: l(3)mbt ChIP, Canton S source_name=Third instar larval brain and wing/haltere/th...ird leg imaginal discs tissue, l(3)mbt ChIP || strain=Canton S || tissue=third instar larval brain and wing/

  1. Experiment list: SRX507383 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available + (wildtype) || age of animals=1-5 day old || tissue=Ovaries || chip antibody=Anti-H3K4me2 || chip antibody ... Anti-H3K4me2- replicate#1; Drosophila melanogaster; ChIP-Seq source_name=WT_WT_Anti-H3K4me2 || strain=piwi/

  2. Experiment list: SRX507384 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available + (wildtype) || age of animals=1-5 day old || tissue=Ovaries || chip antibody=Anti-H3K4me2 || chip antibody ... Anti-H3K4me2- replicate#2; Drosophila melanogaster; ChIP-Seq source_name=WT_WT_Anti-H3K4me2 || strain=piwi/

  3. Experiment list: SRX507382 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available + (wildtype) || age of animals=1-5 day old || tissue=Ovaries || chip antibody=Anti-H3K9me3 || chip antibody ... Anti-H3K9me3- replicate#2; Drosophila melanogaster; ChIP-Seq source_name=WT_WT_Anti-H3K9me3 || strain=piwi/

  4. Experiment list: SRX507380 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available + (wildtype) || age of animals=1-5 day old || tissue=Ovaries || chip antibody=anti-HP1 || chip antibody vend...1770: WT anti-HP1- replicate#2; Drosophila melanogaster; ChIP-Seq source_name=WT_WT_anti-HP1 || strain=piwi/

  5. Experiment list: SRX791596 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available idered part of the BASAL GANGLIA. 172081391,94.4,6.9,1090 GSM1556658: C Input; Mus musculus; ChIP-Seq source_name=mouse cocai...ne NAc ChIP input || tissue=nucleus accumbens || chip antibody=input || strategy=ChIP-seq || treatment=Cocai

  6. A microfluidic chip for electrochemical conversions in drug metabolism studies

    NARCIS (Netherlands)

    Odijk, Mathieu; Baumann, A.; Lohmann, W.; van den Brink, Floris Teunis Gerardus; Olthuis, Wouter; Karst, U.; van den Berg, Albert

    2009-01-01

    We have designed a microfluidic microreactor chip for electrochemical conversion of analytes, containing a palladium reference electrode and platinum working and counter electrodes. The counter electrode is placed in a separate side-channel on chip to prevent unwanted side-products appearing in the

  7. Experiment list: SRX214077 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available erentiated || treatment=Overexpress Sox17_V5 tagged || cell line=KH2 || chip antibody 1=Sox17 || chip antibo... musculus; ChIP-Seq source_name=KH2 ES cells || cell type=Embryonic stem cells || developmental stage=Undiff

  8. Exploration within the Network-on-Chip Paradigm

    NARCIS (Netherlands)

    Wolkotte, Pascal Theodoor

    2009-01-01

    A general purpose processor used to consist of a single processing core, which performed and controlled all tasks on the chip. Its functionality and maximum clock frequency grew steadily over the years. Due to the continuous increase of the number of transistors available on-chip and the operational

  9. Experiment list: SRX183788 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available idin ChIP || chip antibody=Strepdavidin http://dbarchive.biosciencedbc.jp/kyushu-u/...us musculus; ChIP-Seq source_name=nTreg cells, Foxo1tagBirA mice || cell type=nTreg, Foxo1tagBirA strepdav

  10. Experiment list: SRX682274 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available IPseq; Mus musculus; ChIP-Seq source_name=CD4+ cells, Foxo1tagBirA mice || strain=C57BL/6 || cell type=CD4+, Foxo1tagBirA strepdavid...in ChIP || chip antibody=Strepdavidin http://dbarchive.bi

  11. Experiment list: SRX265314 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available | tissue=liver || treatment=veh || replicate=rep1 || chip antibody=C/EBPbeta sc-150, san...ta cruz || chip antibody manufacturer=Santa Cruz http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/eachD

  12. Experiment list: SRX265316 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available | tissue=liver || treatment=veh || replicate=rep2 || chip antibody=C/EBPbeta sc-150, san...ta cruz || chip antibody manufacturer=Santa Cruz http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/eachD

  13. Experiment list: SRX494822 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available SRX494822 ce10 TFs and others lin-53 Larvae L3 NA 16560194,96.7,12.3,0 GSM1217234: seq-SDQ2370 LIN53... N2 L3 ChIP Rep2; Caenorhabditis elegans; ChIP-Seq source_name=seq-SDQ2370_LIN53_N2_L3_ChIP

  14. Multiplex polymerase chain reaction (PCR) on a SU-8 chip

    DEFF Research Database (Denmark)

    Christensen, Troels Balmer; Bang, Dang Duong; Wolff, Anders

    2008-01-01

    We present the detection of Campylobacter at species level using multiplex PCR in a micro fabricated PCR chip. The chip is based on the polymer SU-8 that allows integration with different microfluidic components, e.g., sample pre-treatment before PCR, and DNA detection simultaneously with or afte...

  15. Experiment list: SRX365701 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available orsal closure stage 25412489,60.9,79.9,2860 GSM1246073: rump-10c3-a; Drosophila melanogaster; ChIP-Seq source_name=Kc167_Rump..._ChIP-seq || cell line=Kc167 || chip antibody=Rump 10c3 || chip antibody reference=PMID:182

  16. Experiment list: SRX365702 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available orsal closure stage 22143112,45.7,68.4,2362 GSM1246074: rump-5g4-a; Drosophila melanogaster; ChIP-Seq source_name=Kc167_Rump..._ChIP-seq || cell line=Kc167 || chip antibody=Rump 5g4 || chip antibody reference=PMID:18234

  17. WAVELET BASED SPECTRAL CORRELATION METHOD FOR DPSK CHIP RATE ESTIMATION

    Institute of Scientific and Technical Information of China (English)

    Li Yingxiang; Xiao Xianci; Tai Hengming

    2004-01-01

    A wavelet-based spectral correlation algorithm to detect and estimate BPSK signal chip rate is proposed. Simulation results show that the proposed method can correctly estimate the BPSK signal chip rate, which may be corrupted by the quadratic characteristics of the spectral correlation function, in a low SNR environment.

  18. The Cutting Process, Chips and Cutting Forces in Machining CFRP

    DEFF Research Database (Denmark)

    Koplev, A.; Lystrup, Aage; Vorm, T.

    1983-01-01

    The cutting of unidirectional CFRP, perpendicular as well as parallel to the fibre orientation, is examined. Shaping experiments, ‘quick-stop’ experiments, and a new chip preparation technique are used for the investigation. The formation of the chips, and the quality of the machined surface...

  19. Experiment list: SRX063290 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ype/variation=t(4;14)-associated NSD2 allele knocked-out || gender=Female || chip antibody=anti-H3K36me2 || chip antibody vendor=Acti...ve Motif http://dbarchive.biosciencedbc.jp/kyushu-u/hg19

  20. Experiment list: SRX081812 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available 751461: F1i ChIP Seq H3K27ac (GAII) source_name=Frontal cortex || strain=129X1/SvJ x Cast/EiJ || chip-antibody=H3K27ac || vendor=Acti...ve Motif, AM39133 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/eachData/bw/SRX081

  1. Solving wood chip transport problems with computer simulation.

    Science.gov (United States)

    Dennis P. Bradley; Sharon A. Winsauer

    1976-01-01

    Efficient chip transport operations are difficult to achieve due to frequent and often unpredictable changes in distance to market, chipping rate, time spent at the mill, and equipment costs. This paper describes a computer simulation model that allows a logger to design an efficient transport system in response to these changing factors.

  2. Organ-on-a-Chip: Interfacing with living tissue

    NARCIS (Netherlands)

    Dekker, R.

    2013-01-01

    “A what on a chip?” is what most people ask with disbelief when they hear for the first time of the new and very exciting research area “Organ on a Chip.” The topic has nothing to do with Science Fiction, but everything with a very surprising encounter between two completely different research

  3. Experiment list: SRX037430 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available =peripheral blood mononuclear cells 14488927,12.8,2.8,1378 GSM648492: Treg-H3K4me1 source_name=Treg cells fr...om PBMC, normal || gender=male || cell type=Treg cells || chip antibody=H3K4me1 || chip antibody vendor=Abca

  4. Experiment list: SRX037431 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available =peripheral blood mononuclear cells 20224353,15.6,11.0,26171 GSM648493: Treg-H3K4me3 source_name=Treg cells ...from PBMC, normal || gender=male || cell type=Treg cells || chip antibody=H3K4me3 || chip antibody vendor=Ab

  5. Brain-on-a-chip integrated neuronal networks

    NARCIS (Netherlands)

    Xie, Sijia

    2016-01-01

    The brain-on-a-chip technology aims to provide an efficient and economic in vitro platform for brain disease study. In the well-known literature on brain-on-a-chip systems, nonstructured surfaces were conventionally used for the cell attachment in a culture chamber, therefore the neuronal networks g

  6. Experiment list: SRX213410 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available GSM1058733: MS OVX K27me3 ChIPSeq; Mus musculus; ChIP-Seq GEO Accession=GSM1058733 || cell type=Mammary stem cells || state=ovariecto...mized || chip antibody=Histone H3 trimethyl Lys27 || strain=FVB/N || chip antibody

  7. Experiment list: SRX213419 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available 058742: Luminal OVX K27me3 ChIPSeq; Mus musculus; ChIP-Seq source_name=mammary gland || cell type=Luminal cells || state=ovariectomiz...ed || chip antibody=Histone H3 trimethyl Lys27 || strain=FVB/N || chip antibody man

  8. Experiment list: SRX213409 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available 1058732: MS OVX K4me3 ChIPSeq; Mus musculus; ChIP-Seq source_name=mammary gland || cell type=Mammary stem cells || state=ovariectomiz...ed || chip antibody=Histone H3 trimethyl Lys4 || strain=FVB/N || chip antibody manu

  9. Experiment list: SRX190339 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available | antibody=RevXlinkChromatin || treatment=None || treatment description=No special treatment or protocol applies || protocol...=v042211.1 || protocol description=Faster ChIP protocol & AMpure XP size selection for ChIP-

  10. Experiment list: SRX382353 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available air, by a process called melanogenesis. Coloration can be altered by the number of melanocytes or the amount...hIPSeq; Homo sapiens; ChIP-Seq source_name=Hmel human melanocytes, RNF2 ChIP || cell line=HMEL-BRAFV600E || ...cell type=immortalized melanocytes || chip antibody=V5 (Abcam ab9116, lot# 754608

  11. Experiment list: SRX382354 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available air, by a process called melanogenesis. Coloration can be altered by the number of melanocytes or the amount...ChIPSeq; Homo sapiens; ChIP-Seq source_name=Hmel human melanocytes, RNF2 ChIP || cell line=HMEL-BRAFV600E ||... cell type=immortalized melanocytes || chip antibody=V5 (Abcam ab9116, lot# 75460

  12. Experiment list: SRX220827 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available n fetal lung fibroblast cells, growing, H3K4me3 ChIP || cell line=IMR90 || cell type=human fetal lung fibrob...last cell line || growth state=growing || chip antibody=anti-H3K4me3 http://dbarc

  13. SNP typing on the NanoChip electronic microarray

    DEFF Research Database (Denmark)

    Børsting, Claus; Sanchez Sanchez, Juan Jose; Morling, Niels

    2005-01-01

    We describe a single nucleotide polymorphism (SNP) typing protocol developed for the NanoChip electronic microarray. The NanoChip array consists of 100 electrodes covered by a thin hydrogel layer containing streptavidin. An electric currency can be applied to one, several, or all electrodes...

  14. Fast prototyping of injection molded polymer microfluidic chips

    DEFF Research Database (Denmark)

    Hansen, Thomas Steen; Selmeczi, David; Larsen, Niels Bent

    2010-01-01

    , likely due to the resulting reduction in sidewall steepness. We employed the latter method for injection molding bondable polymer microfluidic chips with integrated conducting polymer electrode arrays that permitted the culture and on-chip analysis of cell spreading by impedance spectroscopy....

  15. Architectural modeling of pixel readout chips Velopix and Timepix3

    NARCIS (Netherlands)

    Poikela, T.; Plosila, J.; Westerlund, T.; Buytaert, J.; Campbell, M.; Llopart, X.; Plackett, R.; Wyllie, K.; van Beuzekom, M.; Gromov, V.; Kluit, R.; Zappon, F.; Zivkovic, V.; Brezina, C.; Desch, K.; Fang, X.; Kruth, A.

    2012-01-01

    We examine two digital architectures for front end pixel readout chips, Velopix and Timepix3. These readout chips are developed for tracking detectors in future high energy physics experiments. They must incorporate local intelligence in pixels for time-over-threshold measurement and sparse readout.

  16. Experiment list: SRX262790 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available IH3T3_MRTFB_15 || cell line=NIH3T3 fibroblasts || genotype=normal || chip antibody=MRTF-B || chip antibody vendor=Santa Cruz Biotechn...ology http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/eac

  17. Experiment list: SRX262785 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available H3T3_MRTFA_03 || cell line=NIH3T3 fibroblasts || genotype=normal || chip antibody=MRTF-A || chip antibody vendor=Santa Cruz Biotechno...logy http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/each

  18. Experiment list: SRX262781 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available _name=NIH3T3_SRF_15 || cell line=NIH3T3 fibroblasts || genotype=normal || chip antibody=SRF || chip antibody vendor=Santa Cruz Biotec...hnology http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/e

  19. Experiment list: SRX262798 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available 3T3_SAP1_15 || cell line=NIH3T3 fibroblasts || genotype=normal || chip antibody=SAP-1a || chip antibody vendor=Santa Cruz Biotechnolo...gy http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/eachDa

  20. Experiment list: SRX262787 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available IH3T3_MRTFA_LAT || cell line=NIH3T3 fibroblasts || genotype=normal || chip antibody=MRTF-A || chip antibody vendor=Santa Cruz Biotech...nology http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/ea

  1. CHIPS. Volume 29, Issue 2, April - June 2011

    Science.gov (United States)

    2011-06-01

    specialized resources to provide the means to rap - idly resolve fleet voice communications issues. As the Navy’s secure voice In- Service Engineering...CHIPS www.chips.navy.mil Dedicated to Sharing Information - Technology - Experience In an orchestra, each musician produces exquisite music

  2. Experiment list: SRX1553105 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ogenitor cells from which all blood cells derive. 42977561,89.4,87.1,17720 MEF2 ChIP Exo July2013 HPC 130709... HS3A: Sample MEF2 ChIP Exo July2013 HPC 130709 HS3A isolate=NKRT5A_index2 || breed=black 6 || age=8-12 week

  3. Experiment list: SRX1553109 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available SRX1553109 mm9 No description NA Blood Pro-B cells NA 269818868,85.9,95.0,34602 MEF2 ChIP Exo July...2013 HPC 130709 HS3A: Sample Mef2 ChIP Exo July 2012 isolate=NKRT1 || breed=black 6 || age=8-

  4. Experiment list: SRX403440 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available GSM1299411: Control, Input round #2; Drosophila melanogaster; ChIP-Seq source_name=Control, Input || age=10 days old || genotype/vari...ation=elav-GAL4/Y || Sex=male || tissue=whole heads || chip antibody=none || chip a

  5. Experiment list: SRX1038538 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available 695731: H7660 Red1 ChIP in rec8 delta biological replicate 2; Saccharomyces cerevisiae; ChIP-Seq source_name...=Red1 ChIP in rec8 delta biological replicate 2 || strain=sk1 || meiotic timepoint=3 hour || genotype=rec8 d

  6. Experiment list: SRX1038541 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available 1695734: H8083 Red1 ChIP in pREC8-SCC1 biological replicate 1; Saccharomyces cerevisiae; ChIP-Seq source_nam...e=Red1 ChIP in pREC8-SCC1 biological replicate 1 || strain=sk1 || meiotic timepoint=3 hour || genotype=pREC8

  7. Experiment list: SRX1038542 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available 1695735: H8083 Red1 ChIP in pREC8-SCC1 biological replicate 2; Saccharomyces cerevisiae; ChIP-Seq source_nam...e=Red1 ChIP in pREC8-SCC1 biological replicate 2 || strain=sk1 || meiotic timepoint=3 hour || genotype=pREC8

  8. Experiment list: SRX1038532 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available 695725: H4471 Rec8 ChIP biological replicate 2; Saccharomyces cerevisiae; ChIP-Seq source_name=Red1 ChIP of H4471 biolog...SRX1038532 sacCer3 TFs and others RED1 Yeast strain SK1 NA 1426016,92.6,26.8,0 GSM1

  9. Experiment list: SRX1038537 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available 1695730: H6200 Red1 ChIP in rec8 delta biological replicate 1; Saccharomyces cerevisiae; ChIP-Seq source_nam...e=Red1 ChIP in rec8 delta biological replicate 1 || strain=sk1 || meiotic timepoint=3 hour || genotype=rec8

  10. Experiment list: SRX1038526 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available 695719: H119 Red1 ChIP biological replicate 2; Saccharomyces cerevisiae; ChIP-Seq source_name=Red1 ChIP of H119 biolog...SRX1038526 sacCer3 TFs and others RED1 Yeast strain SK1 NA 6440074,94.5,38.5,0 GSM1

  11. Experiment list: SRX1038525 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available 1695718: H119 Red1 ChIP biological replicate 1; Saccharomyces cerevisiae; ChIP-Seq source_name=Red1 ChIP of H119 biolog...SRX1038525 sacCer3 TFs and others RED1 Yeast strain SK1 NA 22907545,92.4,48.3,0 GSM

  12. Experiment list: SRX1038534 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available 95727: H6309 Smc3 ChIP biological replicate 1; Saccharomyces cerevisiae; ChIP-Seq source_name=Smc3 ChIP of H6309 biolog...SRX1038534 sacCer3 TFs and others SMC3 Yeast strain SK1 NA 1594898,87.7,9.1,0 GSM16

  13. Flow control in microfluidic chips : Material choice and smart design

    NARCIS (Netherlands)

    Debrauwer, P.; Emmelkamp, J.; Bolt, P.J.

    2009-01-01

    This paper describes a model and experiments to validate it for the design of bubble free chambers and channels in microfluidic chips. When handling liquids in a microfluidic chip problems may arise with entrapping air or liquid. These air and liquid bubbles deteriorate the efficiency of the process

  14. An automatic system for elaboration of chip breaking diagrams

    DEFF Research Database (Denmark)

    Andreasen, Jan Lasson; De Chiffre, Leonardo

    1998-01-01

    A laboratory system for fully automatic elaboration of chip breaking diagrams has been developed and tested. The system is based on automatic chip breaking detection by frequency analysis of cutting forces in connection with programming of a CNC-lathe to scan different feeds, speeds and cutting...

  15. Experiment list: SRX1338947 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ription=Progenitor cells from which all blood cells derive. 38987751,98.2,6.0,267 GSM1909031: Resistant line ChIP input...tion=Resistant || strain=C57BL/6 || chip antibody=none (input) http://dbarchive.b

  16. Experiment list: SRX365696 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available e_name=Kc167_CP190_ChIP-seq || cell line=Kc167 || chip antibody=CP190 rabbit || chip antibody reference=PMID:21852534 || input... used=input-b http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/ea

  17. Experiment list: SRX671992 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ; Mus musculus; ChIP-Seq source_name=embryonic stem cells, TC11, empty vector, input || strain/background=12...9/Ola || transchromosomic=hsa11 || plasmid=empty vector || chip_or_input=input DNA || chip antibody=none ||

  18. Experiment list: SRX262797 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available 3T3_SAP1_03 || cell line=NIH3T3 fibroblasts || genotype=normal || chip antibody=SAP-1a || chip antibody vendor=Santa Cruz Biotechnolo...gy http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/eachDa

  19. Experiment list: SRX262791 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available nology http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/ea...IH3T3_MRTFB_LAT || cell line=NIH3T3 fibroblasts || genotype=normal || chip antibody=MRTF-B || chip antibody vendor=Santa Cruz Biotech

  20. Experiment list: SRX507381 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available + (wildtype) || age of animals=1-5 day old || tissue=Ovaries || chip antibody=Anti-H3K9me3 || chip antibody ...Anti-H3K9me3 - replicate#1; Drosophila melanogaster; ChIP-Seq source_name=WT_WT_Anti-H3K9me3 || strain=piwi/

  1. Experiment list: SRX398290 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available GSM1296633: LY1 DMSO WCE ChipSeq; Homo sapiens; ChIP-Seq source_name=Diffuse Large B-Cell Lymphoma || chip ...antibody=None || antibody catalog number=None WCE || cell line=LY1 || cell type=Diffuse Large B-Cell Lymphom

  2. Experiment list: SRX398289 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available GSM1296632: LY1 JQ1 WCE ChipSeq; Homo sapiens; ChIP-Seq source_name=Diffuse Large B-Cell Lymphoma || chip a...ntibody=None || antibody catalog number=None WCE || cell line=LY1 || cell type=Diffuse Large B-Cell Lymphoma

  3. Experiment list: SRX398295 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ,15337 GSM1296638: LY1 JQ1 POL2 ChipSeq; Homo sapiens; ChIP-Seq source_name=Diffuse Large B-Cell Lymphoma ||... chip antibody=RNA Pol II (Rpb1 N-terminus) || antibody catalog number=Santa Cruz SC-899 || cell line=LY1 || cell type=Diffuse

  4. Experiment list: SRX398293 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available 636: LY1 JQ1 BRD4 ChipSeq; Homo sapiens; ChIP-Seq source_name=Diffuse Large B-Cell Lymphoma || chip antibody...=Brd4 || antibody catalog number=Bethyl A301-985A || cell line=LY1 || cell type=Diffuse Large B-Cell Lymphom

  5. Experiment list: SRX398288 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available GSM1296631: LY1 WT WCE ChipSeq; Homo sapiens; ChIP-Seq source_name=Diffuse Large B-Cell Lymphoma || chip ant...ibody=None || antibody catalog number=None WCE || cell line=LY1 || cell type=Diffuse Large B-Cell Lymphoma h

  6. Experiment list: SRX398292 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ,5985 GSM1296635: LY1 DMSO POL2 ChipSeq; Homo sapiens; ChIP-Seq source_name=Diffuse Large B-Cell Lymphoma ||... chip antibody=RNA Pol II (Rpb1 N-terminus) || antibody catalog number=Santa Cruz SC-899 || cell line=LY1 || cell type=Diffuse

  7. Experiment list: SRX398294 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available 6637: LY1 WT MED1 ChipSeq; Homo sapiens; ChIP-Seq source_name=Diffuse Large B-Cell Lymphoma || chip antibody...=Med1/TRAP220 || antibody catalog number=Bethyl A300-793A || cell line=LY1 || cell type=Diffuse Large B-Cell

  8. Experiment list: SRX398291 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available 6634: LY1 DMSO BRD4 ChipSeq; Homo sapiens; ChIP-Seq source_name=Diffuse Large B-Cell Lymphoma || chip antibo...dy=Brd4 || antibody catalog number=Bethyl A301-985A || cell line=LY1 || cell type=Diffuse Large B-Cell Lymph

  9. Interconnects and On-Chip Data Communication Techniques

    NARCIS (Netherlands)

    Mensink, E.; Schinkel, Daniel; Klumperink, Eric A.M.; van Tuijl, Adrianus Johannes Maria

    Global on-chip communication is rapidly becoming a speed and power bottleneck in CMOS circuits. In this paper, a ‘mixed-signal’ approach is taken to analyze on-chip interconnects and it is investigated how data-rates can be improved. It is shown that complex signaling schemes such as OFDM and CDMA

  10. Advanced Micro Narrows Gap in Race for New Chip

    Institute of Scientific and Technical Information of China (English)

    John Markoff; 张宁

    2004-01-01

    @@ Hoping to catch up with Intel and I. B. M. in an advanced chip-making technology, the semiconductor maker Advanced Micro Devices plans to announce Tuesday that it has begun to ship chips based on an advanced manufacturing process that is being used to build the next generation of processors.

  11. Experiment list: SRX143798 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available 50.2,45.7,17688 GSM918706: LICR ChipSeq WholeBrain Pol2 E14.5 source_name=WholeBrain || biomaterial_provider...pe=ChipSeq || datatype description=Chromatin IP Sequencing || cell=WholeBrain || ...cell organism=mouse || cell description=Whole Brain || cell sex=U || antibody=Pol2 || antibody antibodydescr

  12. Experiment list: SRX684779 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available l type=induced pluripotent stem cells || chip antibody=Mnase-ChIP with anti-Histone H3 antibody (ab1791, ChIP grade) || genetic backg...round=CBA/CaJ and C57BL/6J http://dbarchive.biosciencedb

  13. Thermal Management for Dependable On-Chip Systems

    OpenAIRE

    Ebi, Thomas

    2014-01-01

    This thesis addresses the dependability issues in on-chip systems from a thermal perspective. This includes an explanation and analysis of models to show the relationship between dependability and tempature. Additionally, multiple novel methods for on-chip thermal management are introduced aiming to optimize thermal properties. Analysis of the methods is done through simulation and through infrared thermal camera measurements.

  14. Experiment list: SRX665235 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available issue Diagnosis=Adenocarcinoma 150547052,97.7,31.1,2315 GSM1448893: PolIIS2ph ChIP in BIX treated RNaseH1 overexpressing... cells; Homo sapiens; ChIP-Seq source_name=PolIIS2ph ChIP in BIX treated RNaseH1 overexpressing

  15. Experiment list: SRX088969 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available iate into specialized cells. 59749730,89.3,37.2,913 GSM773066: HA ChIP in ES cells expressing... HAZFP57 source_name=HA ChIP in ES cells expressing HAZFP57 || cell type=embryonic stem (ES) cel

  16. Experiment list: SRX331407 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available 9: H4K16ac(M).L3.Solexa ChIP Rep1; Drosophila melanogaster; ChIP-Seq source_name=H4K16ac(M).L3 ChIP expt.2514 || strain=Oregon-R(offi...cial name : Oregon-R-modENCODE genotype : wild type ) || developmental stage=3rd In

  17. Experiment list: SRX331408 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available 0: H4K16ac(M).L3.Solexa ChIP Rep2; Drosophila melanogaster; ChIP-Seq source_name=H4K16ac(M).L3 ChIP expt.2515 || strain=Oregon-R(offi...cial name : Oregon-R-modENCODE genotype : wild type ) || developmental stage=3rd In

  18. Exploration within the Network-on-Chip Paradigm

    NARCIS (Netherlands)

    Wolkotte, P.T.

    2009-01-01

    A general purpose processor used to consist of a single processing core, which performed and controlled all tasks on the chip. Its functionality and maximum clock frequency grew steadily over the years. Due to the continuous increase of the number of transistors available on-chip and the operational

  19. Experiment list: SRX149661 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available sue Diagnosis=Carcinoma 60114830,96.8,20.7,14454 GSM937563: CDK8-ChIP enriched DNA, hypoxia, replicate2; Hom...o sapiens; ChIP-Seq source_name=colorectal cancer cells, hypoxia, CDK8 ChIP || cell line=HCT116 || treatment

  20. Experiment list: SRX149660 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available sue Diagnosis=Carcinoma 164134451,96.9,12.9,25737 GSM937562: CDK8-ChIP enriched DNA, hypoxia, replicate1; Ho...mo sapiens; ChIP-Seq source_name=colorectal cancer cells, hypoxia, CDK8 ChIP || cell line=HCT116 || treatmen