WorldWideScience

Sample records for chip scale liquid

  1. Towards Chip Scale Liquid Chromatography and High Throughput Immunosensing

    Energy Technology Data Exchange (ETDEWEB)

    Ni, J.

    2000-09-21

    This work describes several research projects aimed towards developing new instruments and novel methods for high throughput chemical and biological analysis. Approaches are taken in two directions. The first direction takes advantage of well-established semiconductor fabrication techniques and applies them to miniaturize instruments that are workhorses in analytical laboratories. Specifically, the first part of this work focused on the development of micropumps and microvalves for controlled fluid delivery. The mechanism of these micropumps and microvalves relies on the electrochemically-induced surface tension change at a mercury/electrolyte interface. A miniaturized flow injection analysis device was integrated and flow injection analyses were demonstrated. In the second part of this work, microfluidic chips were also designed, fabricated, and tested. Separations of two fluorescent dyes were demonstrated in microfabricated channels, based on an open-tubular liquid chromatography (OT LC) or an electrochemically-modulated liquid chromatography (EMLC) format. A reduction in instrument size can potentially increase analysis speed, and allow exceedingly small amounts of sample to be analyzed under diverse separation conditions. The second direction explores the surface enhanced Raman spectroscopy (SERS) as a signal transduction method for immunoassay analysis. It takes advantage of the improved detection sensitivity as a result of surface enhancement on colloidal gold, the narrow width of Raman band, and the stability of Raman scattering signals to distinguish several different species simultaneously without exploiting spatially-separated addresses on a biochip. By labeling gold nanoparticles with different Raman reporters in conjunction with different detection antibodies, a simultaneous detection of a dual-analyte immunoassay was demonstrated. Using this scheme for quantitative analysis was also studied and preliminary dose-response curves from an immunoassay of a

  2. Liquid Chromatography on chip

    OpenAIRE

    Faure, Karine

    2010-01-01

    Abstract Liquid chromatography is one of the most powerful separation techniques as illustrated by its leading role in analytical sciences through both academic and industrial communities. Its implementation in microsystems appears to be crucial in the development of ?TAS. If electrophoretic techniques have been widely used in miniaturized devices, liquid chromatography has faced multiple challenges in the downsizing process. During the past five years significant breakthroughs...

  3. Plasmonics: the next chip-scale technology

    Directory of Open Access Journals (Sweden)

    Rashid Zia

    2006-07-01

    Full Text Available The development of chip-scale electronics and photonics has led to remarkable data processing and transport capabilities that permeate almost every facet of our lives. Plasmonics is an exciting new device technology that has recently emerged. It exploits the unique optical properties of metallic nanostructures to enable routing and manipulation of light at the nanoscale. A tremendous synergy can be attained by integrating plasmonic, electronic, and conventional dielectric photonic devices on the same chip and taking advantage of the strengths of each technology.

  4. On-chip liquid storage and dispensing for lab-on-a-chip applications

    International Nuclear Information System (INIS)

    This work presents novel components for on-chip storage and dispensing inside a lab-on-a-chip (LOC) for applications in immunoassay point-of-care testing (POCT), where incubation and washing steps are essential. It involves easy-to-use on-chip solutions for the sequential thermo-hydraulic actuation of liquids. The novel concept of combining the use of a rubber plug, both as a non-return valve cap and as a liquid injection interface of a sealed reservoir, allows simple filling of a sterilized cavity, as well as the storage and dispensing of reagent and washing buffer liquids. Segmenting the flow with air spacers enables effective rinsing and the use of small volumes of on-chip stored liquids. The chip uses low-resistance resistors as heaters in the paraffin actuator, providing the low-voltage actuation that is preferred for handheld battery driven instruments

  5. Liquid-phase microextraction in a microfluidic-chip

    DEFF Research Database (Denmark)

    Payán, María D. Ramos; Jensen, Henrik; Petersen, Nickolaj J.;

    2012-01-01

    In this work, a microfluidic-chip based system for liquid-phase microextraction (LPME-chip) was developed. Sample solutions were pumped into the LPME-chip with a micro-syringe pump at a flow rate of 3-4µLmin(-1). Inside the LPME chip, the sample was in direct contact with a supported liquid...... electrophoresis for exact quantification, or on-line by UV detection or electrospray ionization mass spectrometry for time profiling of concentrations. The LPME-chip was found to be highly effective, and extraction efficiencies were in the range of 52-91%. When the flow of acceptor phase was turned off during...... that the LPME-chip has great potentials for very efficient analyte enrichments from limited sample volumes in the future....

  6. Cool down computer chips with liquid metal device driven by the heat of chips

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ With the soaring advances in computational speed, thermal management becomes a major concern in computer systems. To remove heat generated by computer chips or very large scale integrated circuits, a research team headed by Prof.

  7. Liquid metal cooling in thermal management of computer chips

    Institute of Scientific and Technical Information of China (English)

    MA Kunquan; LIU Jing

    2007-01-01

    With the rapid improvement of computer performance,tremendous heat generation in the chip becomes a major serious concern for thermal management.Meanwhile,CPU chips are becoming smaller and smaller with almost no room for the heat to escape.The total power-dissipation levels now reside on the order of 100 W with a peak power density of 400-500 W/cm2,and are still steadily climbing.As a result,it is extremely hard to attain higher performance and reliability.Because the conventional conduction and forcedair convection techniques are becoming incapable in providing adequate cooling for sophisticated electronic systems,new solutions such as liquid cooling,thermoelectric cooling,heat pipes,vapor chambers,etc.are being studied.Recently,it was realized that using a liquid metal or its alloys with a low melting point as coolant could significantly lower the chip temperature.This new generation heat transfer enhancement method raised many important fundamentals and practical issues to be solved.To accommodate to the coming endeavor in this area,this paper is dedicated to presenting an overall review on chip cooling using liquid metals or their alloys as coolant.Much more attention will be paid to the thermal properties of liquid metals with low melting points or their alloys and their potential applications in the chip cooling.Meanwhile,principles of several typical pumping methods such as mechanical,electromagnetic or peristaltic pumps will be illustrated.Some new advancement in making a liquid metal cooling device will be discussed.The liquid metal cooling is expected to open a new world for computer chip cooling because of its evident merits over traditional coolant.

  8. Monolithic Chip System with a Microfluidic Channel for In Situ Electron Microscopy of Liquids

    DEFF Research Database (Denmark)

    Jensen, Eric; Burrows, Andrew; Mølhave, Kristian

    2014-01-01

    Electron microscopy of enclosed liquid samples requires the thinnest possible membranes as enclosing windows as well as nanoscale liquid sample thickness to achieve the best possible resolution. Today liquid sample systems for transmission electron microscopy (TEM) are typically made from two...... flow geometry, and a better space angle for auxiliary detectors such as energy-dispersive X-ray spectroscopy. We explain the system design and fabrication and show the first successful TEM images of liquid samples in the chips....... sandwiched microchips with thin membranes. We report on a new microfabricated chip system based on a monolithic design that enables membrane geometry on the scale of a few micrometers. The design is intended to reduce membrane deflection when the system is under pressure, a micro fluidic channel for improved...

  9. Fast differential scanning calorimetry of liquid samples with chips

    DEFF Research Database (Denmark)

    Splinter, R.; van Herwaarden, A. W.; van Wetten, I. A.;

    2015-01-01

    Based on a modified version of standard chips for fast differential scanning calorimetry, DSC of liquid samples has been performed at temperature scan rates of up to 1000 °C/s. This paper describes experimental results with the protein lysozyme, bovine serum, and olive oil. The heating and cooling...

  10. Radionuclide analysis based on lab-on-chip liquid-liquid extraction

    International Nuclear Information System (INIS)

    The analysis of radionuclides present in high and medium activity wastes is carried out according to operating protocols including the sequence of many steps of separation/purification. In order to improve these protocols, the micro-fluidic tools have their place. In particular the liquid-liquid extraction in micro-system shows various interests: very few solvent is consumed, the process can be automated and parallelized and the extraction and the stripping can be coupled on a single chip. Liquid-liquid extraction with continuous flow in microsystems has not been tackled until recently since only few chemical systems have been studied, in particular in the nuclear field. Thanks to the characteristics linked to the miniaturization (large specific area, short diffusion length, low reagents volumes), our objective is to control the fluid hydrodynamics for optimizing the contributions of diffusion and convection to the mass transfer in solutions. An exhaustive bibliographical review about the liquid-liquid extraction of metal species on lab-on-chips and preliminary experimental results will be presented and discussed. (authors)

  11. SPIDER: Next Generation Chip Scale Imaging Sensor

    Science.gov (United States)

    Duncan, Alan; Kendrick, Rick; Thurman, Sam; Wuchenich, Danielle; Scott, Ryan P.; Yoo, S. J. B.; Su, Tiehui; Yu, Runxiang; Ogden, Chad; Proiett, Roberto

    The LM Advanced Technology Center and UC Davis are developing an Electro-Optical (EO) imaging sensor called SPIDER (Segmented Planar Imaging Detector for Electro-optical Reconnaissance) that provides a 10x to 100x size, weight, and power (SWaP) reduction alternative to the traditional bulky optical telescope and focal plane detector array. The substantial reductions in SWaP would reduce cost and/or provide higher resolution by enabling a larger aperture imager in a constrained volume. The SPIDER concept consists of thousands of direct detection white-light interferometers densely packed onto Photonic Integrated Circuits (PICs) to measure the amplitude and phase of the visibility function at spatial frequencies that span the full synthetic aperture. In other words, SPIDER would sample the object being imaged in the Fourier domain (i.e., spatial frequency domain), and then digitally reconstruct an image. The conventional approach for imaging interferometers requires complex mechanical delay lines to form the interference fringes. This results in designs that are not traceable to more than a few simultaneous spatial frequency measurements. SPIDER seeks to achieve this traceability by employing micron-=scale optical waveguides and nanophotonic structures fabricated on a PIC with micron-scale packing density to form the necessary interferometers. Prior LM IRAD and DARPA/NASA CRAD-funded SPIDER risk reduction experiments, design trades, and simulations have matured the SPIDER imager concept to a TRL 3 level. Current funding under the DARPA SPIDER Zoom program is maturing the underlying PIC technology for SPIDER to the TRL 4 level. This is done by developing and fabricating a second-generation PIC that is fully traceable to the multiple layers and low-power phase modulators required for higher-dimension waveguide arrays that are needed for higher field-of-view sensors. Our project also seeks to extend the SPIDER concept to add a zoom capability that would provide

  12. Active Solar Sail Designs for Chip-Scale Spacecraft

    OpenAIRE

    Weis, Lorraine; Peck, Mason

    2014-01-01

    Centimeter-scale spacecraft, known as ”Chipsats,” have very high surface-area-to-mass ratios, which accentuates solar radiation pressure (SRP) effects. In contrast to traditional. large solar sails, chip-scale solar sails have the potential to be highly agile in terms of attitude because of their structural rigidity and low moments of inertia. This ability to easily reorient a solar sail greatly expands the orbits that a solar-sail spacecraft can achieve. Solar sail actuation through electroc...

  13. Large scale production of wood chips for fuel

    International Nuclear Information System (INIS)

    The paper is based on the results of the national Wood Energy Technology Programme in 1999 - 2004 and the practical experiences of forest fuel production organizations in Finland. Traditionally, the major barriers to the large-scale use of forest residues for fuel are high cost of production, unsatisfactory fuel quality and unreliable supply. To overcome the barriers, the supply system must be integrated with the existing timber procurement organizations of the forest industries, procurement logistics must be refined, productivity of work must be improved through machine and system development and through learning, and the receiving and handling of chips at a plant must be adapted to wood fuels of variable quality. When the special requirements are met, wood chips are a viable and environmentally friendly fuel for large heating and CHP plants. (author)

  14. Chip-scale cavity optomechanics in lithium niobate

    OpenAIRE

    Jiang, Wei C.; LIN, QIANG

    2016-01-01

    We develop a chip-scale cavity optomechanical system in single-crystal lithium niobate that exhibits high optical quality factors and a large frequency-quality product as high as $3.6\\times 10^{12}$ Hz at room temperature and atmosphere. The excellent optical and mechanical properties together with the strong optomechanical coupling allow us to efficiently excite the coherent regenerative optomechanical oscillation operating at 375.8 MHz with a threshold power of 174 ${\\rm \\mu W}$ in the air....

  15. Chip-scale cavity optomechanics in lithium niobate

    CERN Document Server

    Jiang, Wei C

    2016-01-01

    We develop a chip-scale cavity optomechanical system in single-crystal lithium niobate that exhibits high optical quality factors and a large frequency-quality product as high as $3.6\\times 10^{12}$ Hz at room temperature and atmosphere. The excellent optical and mechanical properties together with the strong optomechanical coupling allow us to efficiently excite the coherent regenerative optomechanical oscillation operating at 375.8 MHz with a threshold power of 174 ${\\rm \\mu W}$ in the air. The demonstrated lithium niobate optomechanical device enables great potential for achieving electro-optic-mechanical hybrid systems for broad applications in sensing, metrology, and quantum physics.

  16. Lab and Bench-Scale Pelletization of Torrefied Wood Chips

    DEFF Research Database (Denmark)

    Shang, Lei; Nielsen, Niels Peter K.; Stelte, Wolfgang;

    2013-01-01

    Combined torrefaction and pelletization is used to increase the fuel value of biomass by increasing its energy density and improving its handling and combustion properties. In the present study, a single-pellet press tool was used to screen for the effects of pellet die temperature, moisture...... content, additive addition, and the degree of torrefaction on the pelletizing properties and pellet quality, i.e., density, static friction, and pellet strength. Results were compared with pellet production using a bench-scale pelletizer. The results indicate that friction is the key factor when scaling...... up from single-pellet press to bench-scale pelletizer. Tuning moisture content or increasing the die temperature did not ease the pellet production of torrefied wood chips significantly. The addition of rapeseed oil as a lubricant reduced the static friction by half and stabilized pellet production...

  17. Photonic wire bonding: a novel concept for chip-scale interconnects

    OpenAIRE

    Lindenmann, N.; Balthasar, G.; Hillerkuss, D.; Schmogrow, R; Jordan, M.; Leuthold, J.; Freude, W; Koos, C.

    2012-01-01

    Photonic integration has witnessed tremendous progress over the last years, and chip-scale transceiver systems with Terabit/s data rates have come into reach. However, as on-chip integration density increases, efficient off-chip interfaces are becoming more and more crucial. A technological breakthrough is considered indispensable to cope with the challenges arising from large-scale photonic integration, and this particularly applies to short-distance optical interconnects. In this letter we ...

  18. 75 FR 51843 - In the Matter of Certain Large Scale Integrated Circuit Semiconductor Chips and Products...

    Science.gov (United States)

    2010-08-23

    ..., based on a complaint filed by Panasonic Corporation (``Panasonic'') of Japan. 75 FR 24742-43. The... COMMISSION In the Matter of Certain Large Scale Integrated Circuit Semiconductor Chips and Products... importation of certain large scale integrated circuit semiconductor chips and products containing same...

  19. Scaling of viscous dynamics in simple liquids

    DEFF Research Database (Denmark)

    Bøhling, Lasse; Ingebrigtsen, Trond; Grzybowski, A.;

    2012-01-01

    Supercooled liquids are characterized by relaxation times that increase dramatically by cooling or compression. From a single assumption follows a scaling law according to which the relaxation time is a function of h(ρ) over temperature, where ρ is the density and the function h(ρ) depends on the...... liquid in question. This scaling is demonstrated to work well for simulations of the Kob–Andersen binary Lennard-Jones mixture and two molecular models, as well as for the experimental results for two van der Waals liquids, dibutyl phthalate and decahydroisoquinoline. The often used power-law density...... scaling, h(ρ)∝ργ, is an approximation to the more general form of scaling discussed here. A thermodynamic derivation was previously given for an explicit expression for h(ρ) for liquids of particles interacting via the generalized Lennard-Jones potential. Here a statistical mechanics derivation is given...

  20. Nanoimprinted polymer chips for light induced local heating of liquids in micro- and nanochannels

    DEFF Research Database (Denmark)

    Thamdrup, Lasse Højlund; Pedersen, Jonas Nyvold; Flyvbjerg, Henrik;

    2010-01-01

    A nanoimprinted polymer chip with a thin near-infrared absorber layer that enables light-induced local heating (LILH) of liquids inside micro- and nanochannels is presented. An infrared laser spot and corresponding hot-spot could be scanned across the device. Large temperature gradients yield...... a 785 nm laser diode was focused from the backside of the chip to a spot diameter down to 5 ..m in the absorber layer, yielding a localized heating (Gaussian profile) and large temperature gradients in the liquid in the nanochannels. A laser power of 38 mW yielded a temperature of 40°C in the center...

  1. Transient Simulation of Two-Phase On-chip Liquid Pump Cycle for Processor's Cooling

    OpenAIRE

    Lamaison, Nicolas; Marcinichen, Jackson Braz; Thome, John Richard

    2012-01-01

    Transient modeling and regulation of a two-phase on-chip liquid pump cooling cycle is studied. The purpose is to cool down multiple micro-processors in parallel and a set of memories, DC/DC converters in series. The cycle will be incorporated in a blade/drawer of a rack as shown in Figure 1. The cooling system is composed of multiple on-chip micro-evaporators, a condenser, a liquid accumulator, a pump and all piping joining components. In order to take advantage of enhanced heat transfer and ...

  2. Integrated Surface-enhanced Raman Spectroscopy chip based on liquid core waveguide

    CERN Document Server

    Lai, Chunhong; Chen, Li; Li, Junhui; Liu, Qinghao; Xu, Yi

    2015-01-01

    We propose an integrated surface enhanced Raman scattering (SERS) chip based on liquid-core waveguide with total reflection, through which the depression of leaky mode enable a long propagating distance. An Raman enhancement factor for rhodamine 6G of 2.5*105 is obtained, and a excellent repeatability is shown. The peaks in the SERS spectrum of DNA of silkworm clearly illustrate the information of the molecule structure. The integration of the SERS substrate, micro-fluid, and liquid-core waveguide make such a SERS chip attractive for biochemical detection with high performance.

  3. A novel monolithic fabrication method for a plastic microfluidic chip with liquid interconnecting ports

    International Nuclear Information System (INIS)

    In the present study, a novel monolithic fabrication method was developed for the manufacturing of a plastic microfluidic chip with liquid interconnecting ports. As the present method can realize both interconnecting ports and through holes, which are essential components for the delivery of working fluids, in the plastic microfluidic chip, no additional processes and external ports are required. Furthermore, the connection of external silicone tubing can be simply achieved by utilizing an elastic deformation of the used tubing. As one representative example, a microinjection molding of a prototype microfluidic chip having two types of interconnecting ports was demonstrated. After obtaining upper and lower plates by the microinjection molding process utilizing mold cores with pin structures, the thermal bonding of the molded plates was carried out, resulting in the prototype plastic microfluidic chip with interconnecting ports. From microfluidic experiments using the fabricated prototype, it was found that the present method could be quite useful in various microfluidic applications

  4. Integrated physics package of a chip-scale atomic clock

    International Nuclear Information System (INIS)

    The physics package of a chip-scale atomic clock (CSAC) has been successfully realized by integrating vertical cavity surface emitting laser (VCSEL), neutral density (ND) filter, λ/4 wave plate, 87Rb vapor cell, photodiode (PD), and magnetic coil into a cuboid metal package with a volume of about 2.8 cm3. In this physics package, the critical component, 87Rb vapor cell, is batch-fabricated based on MEMS technology and in-situ chemical reaction method. Pt heater and thermistors are integrated in the physics package. A PTFE pillar is used to support the optical elements in the physics package, in order to reduce the power dissipation. The optical absorption spectrum of 87Rb D1 line and the microwave frequency correction signal are successfully observed while connecting the package with the servo circuit system. Using the above mentioned packaging solution, a CSAC with short-term frequency stability of about 7 × 10−10 τ−1/2 has been successfully achieved, which demonstrates that this physics package would become one promising solution for the CSAC. (electromagnetism, optics, acoustics, heat transfer, classical mechanics, and fluid dynamics)

  5. On-chip Terahertz Spectroscopy of Liquid Mixtures

    OpenAIRE

    Swithenbank, M; Russell, C; Burnett, AD; Li, L.; Davies, AG; Cunningham, J.; Linfield, E; Wood, CD

    2015-01-01

    We demonstrate 'through-substrate' sensing of fluids for application in the terahertz spectroscopy of biological materials. This technique employs planar Goubau lines with integrated photoconductive material, formed on a flexible, thin polyimide substrate, and bonded to a microfluidic channel. Few-picosecond pulses are used to probe liquid samples confined within the channel, over a total interaction length of 4 mm, overcoming water-absorption limitations of free-space terahertz transmission ...

  6. On the density scaling of liquid dynamics

    Science.gov (United States)

    Fragiadakis, D.; Roland, C. M.

    2011-01-01

    Superpositioning of relaxation data as a function of the product variable TVγ, where T is temperature, V the specific volume, and γ a material constant, is an experimental fact demonstrated for approximately 100 liquids and polymers. Such scaling behavior would result from the intermolecular potential having the form of an inverse power law (IPL), suggesting that an IPL is a good approximation for certain relaxation properties over the relevant range of intermolecular distances. However, the derivation of the scaling property of an IPL liquid is based on reduced quantities, for example, the reduced relaxation time equal to T1/2V-1/3 times the actual relaxation time. The difference between scaling using reduced rather than unreduced units is negligible in the supercooled regime; however, at higher temperature the difference can be substantial, accounting for the purported breakdown of the scaling and giving rise to different values of the scaling exponent. Only the γ obtained using reduced quantities can be sensibly related to the intermolecular potential.

  7. Characterizations of gas purge valves for liquid alignment and gas removal in a microfluidic chip

    International Nuclear Information System (INIS)

    Two polydimethylsiloxane (PDMS) gas purge valves for excessive gas removal in general lab-on-a-chip applications are presented in this paper. Both valves are devised based on a three-layer configuration comprising a top layer for liquid channels, a membrane and a bottom layer for gas channels. The pneumatic valves work as a normal gateway for fluids when the membrane is bulged down (open state) by vacuum or pushed up (closed state) by pressure. In the closed state, the air in front of a liquid can be removed through a small notch or a permeable PDMS membrane by compressing the liquid. The purge valve with a small notch across its valve seat, termed surface-tension (ST) valve, can be operated with pressure under 11.5 kPa. The liquid is mainly retained by the surface tension resulting from the hydrophobic channel walls. In contrast, the purge valve with vacuum-filled grooves adjacent to a liquid channel, termed gas-permeation (GP) valve, can be operated at pressure above 5.5 kPa. Based on the principle of gas permeation, the excessive air can be slowly removed through the vent grooves. Detailed evaluations of both valves in a pneumatically driven microfluidic chip were conducted. Specifically, the purge valves enable users to remove gas and passively align liquids at desired locations without using sensing devices or feedback circuits. Finally, a rapid mixing reaction was successfully performed with the GP valves, showing their practicability as incorporated in a microfluidic chip. (paper)

  8. Liquidity crises on different time scales

    Science.gov (United States)

    Corradi, Francesco; Zaccaria, Andrea; Pietronero, Luciano

    2015-12-01

    We present an empirical analysis of the microstructure of financial markets and, in particular, of the static and dynamic properties of liquidity. We find that on relatively large time scales (15 min) large price fluctuations are connected to the failure of the subtle mechanism of compensation between the flows of market and limit orders: in other words, the missed revelation of the latent order book breaks the dynamical equilibrium between the flows, triggering the large price jumps. On smaller time scales (30 s), instead, the static depletion of the limit order book is an indicator of an intrinsic fragility of the system, which is related to a strongly nonlinear enhancement of the response. In order to quantify this phenomenon we introduce a measure of the liquidity imbalance present in the book and we show that it is correlated to both the sign and the magnitude of the next price movement. These findings provide a quantitative definition of the effective liquidity, which proves to be strongly dependent on the considered time scales.

  9. Integrated Surface-enhanced Raman Spectroscopy chip based on liquid core waveguide

    OpenAIRE

    Lai, Chunhong; Chen, Gang; Chen, Li; Li, Junhui; Liu, Qinghao; Xu, Yi

    2015-01-01

    We propose an integrated surface enhanced Raman scattering (SERS) chip based on liquid-core waveguide with total reflection, through which the depression of leaky mode enable a long propagating distance. An Raman enhancement factor for rhodamine 6G of 2.5*105 is obtained, and a excellent repeatability is shown. The peaks in the SERS spectrum of DNA of silkworm clearly illustrate the information of the molecule structure. The integration of the SERS substrate, micro-fluid, and liquid-core wave...

  10. Advancement in stationary phase for peptide separation helps in protein identification: application to atheroma plaque proteomics using nano-chip liquid chromatography and mass spectrometry.

    Science.gov (United States)

    Delporte, Cédric; Noyon, Caroline; Raynal, Pierre; Dufour, Damien; Nève, Jean; Abts, Frederic; Haex, Martin; Zouaoui Boudjeltia, Karim; Van Antwerpen, Pierre

    2015-03-13

    In the last decades, proteomics has largely progressed. Mass spectrometry and liquid chromatography (LC) are generally used in proteomics. These techniques enable proper separation of peptides and good identification and/or quantification of them. Later, nano-scaled liquid chromatography, improvements of mass spectrometry resolution and sensitivity brought huge advancements. Enhancements in chemistry of chromatographic columns also brought interesting results. In the present work, the potency of identification of proteins by different nano-chip columns was studied and compared with classical LC column. The present study was applied to cardiovascular field where proteomics has shown to be highly helpful in research of new biomarkers. Protein extracts from atheroma plaques were used and proteomics data were compared. Results show that fewer spectra were acquired by the mass spectrometer when nano-chip columns were used instead of the classical ones. However, approximately 40% more unique peptides were identified by the recently optimized chip named Polaris-HR-chip-3C18 column, and 20% more proteins were identified. This fact leads to the identification of more low-abundance proteins. Many of them are involved in atheroma plaque development such as apolipoproteins, ceruloplasmin, etc. In conclusion, present data shows that recent developments of nanoLC column chemistry and dimensions enabled the improved detection and identification of low-abundance proteins in atheroma plaques. Several of them are of major interest in the field of cardiovascular disease. PMID:25680550

  11. Vapor pressure of ionic liquids at low temperatures from AC-chip-calorimetry.

    Science.gov (United States)

    Ahrenberg, Mathias; Beck, Martin; Neise, Christin; Keßler, Olaf; Kragl, Udo; Verevkin, Sergey P; Schick, Christoph

    2016-08-01

    The very low vapor pressure of ionic liquids is challenging to measure. At elevated temperatures the liquids might start to decompose, and at relatively low temperatures the vapor pressure becomes too low to be measured by conventional methods. In this work we developed a highly sensitive method for mass loss determination at temperatures starting from 350 K. This technique is based on an alternating current calorimeter equipped with a chip sensor that consists of a free-standing SiNx-membrane (thickness boiling temperature of [EMIm][NTf2]. The value (1120 ± 50) K should be considered as the first reliable boiling point of the archetypical ionic liquid obtained from experimental vapor pressures measured in the most possible close proximity to the normal boiling temperature. PMID:27425628

  12. Photonic-crystal lasers on silicon for chip-scale optical interconnects

    Science.gov (United States)

    Takeda, Koji; Fujii, Takuro; Shinya, Akihiko; Kuramochi, Eiichi; Notomi, Masaya; Hasebe, Koichi; Kakitsuka, Takaaki; Matsuo, Shinji

    2016-03-01

    Optical interconnects are expected to reduce the power consumption of ICT instruments. To realize chip-to-chip or chip-scale optical interconnects, it is essential to fabricate semiconductor lasers with a smaller energy cost. In this context, we are developing lambda-scale embedded active-region photonic-crystal (LEAP) lasers as light sources for chip-scale optical interconnects. We demonstrated the first continuous-wave (CW) operation of LEAP lasers in 2012 and reported a record low threshold current and energy cost of 4.8 μA and 4.4 fJ/bit at 10 Gbit/s in 2013. We have also integrated photonic crystal photodetectors on the same InP chip and demonstrated waveform transfer along 500-μm-long waveguides. Although LEAP lasers exhibit excellent performance, they have to be integrated on Si wafers for use as light sources for chip-scale optical interconnects. In this paper, we give a brief overview of our LEAP lasers on InP and report our recent progress in fabricating them on Si. We bonded the InP wafers with quantum-well gain layers directly on thermally oxidized Si wafers and performed all process steps on the Si wafer, including high-temperature regrowth. After this process modification, we again achieved CW operation and obtained a threshold current of 57 μA with a maximum output power of more than 3.5 μW at the output waveguides. An output light was successfully guided through 500 × 250-nm InP waveguides.

  13. Chip scale low dimensional materials: optoelectronics & nonlinear optics

    Science.gov (United States)

    Gu, Tingyi

    The CMOS foundry infrastructure enables integration of high density, high performance optical transceivers. We developed integrated devices that assemble resonators, waveguide, tapered couplers, pn junction and electrodes. Not only the volume standard manufacture in silicon foundry is promising to low-lost optical components operating at IR and mid-IR range, it also provides a robust platform for revealing new physical phenomenon. The thesis starts from comparison between photonic crystal and micro-ring resonators based on chip routers, showing photonic crystal switches have small footprint, consume low operation power, but its higher linear loss may require extra energy for signal amplification. Different designs are employed in their implementation in optical signal routing on chip. The second part of chapter 2 reviews the graphene based optoelectronic devices, such as modulators, lasers, switches and detectors, potential for group IV optoelectronic integrated circuits (OEIC). In chapter 3, the highly efficient thermal optic control could act as on-chip switches and (transmittance) tunable filters. Local temperature tuning compensates the wavelength differences between two resonances, and separate electrode is used for fine tuning of optical pathways between two resonators. In frequency domain, the two cavity system also serves as an optical analogue of Autler-Towns splitting, where the cavity-cavity resonance detuning is controlled by the length of pathway (phase) between them. The high thermal sensitivity of cavity resonance also effectively reflects the heat distribution around the nanoheaters, and thus derives the thermal conductivity in the planar porous suspended silicon membrane. Chapter 4 & 5 analyze graphene-silicon photonic crystal cavities with high Q and small mode volume. With negligible nonlinear response to the milliwatt laser excitation, the monolithic silicon PhC turns into highly nonlinear after transferring the single layer graphene with

  14. Design and implementation of an automated liquid-phase microextraction-chip system coupled on-line with high performance liquid chromatography

    DEFF Research Database (Denmark)

    Li, Bin; Petersen, Nickolaj J.; Payán, María D Ramos;

    2014-01-01

    An automated liquid-phase microextraction (LPME) device in a chip format has been developed and coupled directly to high performance liquid chromatography (HPLC). A 10-port 2-position switching valve was used to hyphenate the LPME-chip with the HPLC autosampler, and to collect the extracted...... analytes, which then were delivered to the HPLC column. The LPME-chip-HPLC system was completely automated and controlled by the software of the HPLC instrument. The performance of this system was demonstrated with five alkaloids i.e. morphine, codeine, thebaine, papaverine, and noscapine as model analytes....... The composition of the supported liquid membrane (SLM) and carrier was optimized in order to achieve reasonable extraction performance of all the five alkaloids. With 1-octanol as SLM solvent and with 25mM sodium octanoate as anionic carrier, extraction recoveries for the different opium alkaloids...

  15. Thermal characterization of overmolded underfill materials for stacked chip scale packages

    International Nuclear Information System (INIS)

    Stacked chip scale package (SCSP) is a new electronic packaging technology for non-CPU products, such as hand-held computing and communication devices. In this technology, one or more wire-bonded silicon chips are stacked on top of another flipped silicon chip, and an overmolded underfill encapsulant is used to both encapsulate and underfill the wire-bonded chip and the flip chip in a single process. In this paper, the cure behavior, thermal stability, filler content, and thermomechanical properties of five overmolded underfill materials have been studied using DSC, TGA, TMA, and DMA. Results showed that there is a strong correlation between thermomechanical properties and the filler content of the material. Based on measured thermomechanical properties, a 'figure-of-merit' approach was used to estimate the thermal stress induced in the package upon cooling. Results showed that an OMUF material with a low T g, low coefficient of thermal expansion (CTE), and low modulus can effectively reduce the package thermal stress. The reliability results are in good agreement with the predictions based on thermal stress estimation

  16. User-Loaded SlipChip for Equipment-Free Multiplexed Nanoliter-Scale Experiments

    Energy Technology Data Exchange (ETDEWEB)

    Li, Liang; Du, Wenbin; Ismagilov, Rustem (UC)

    2010-08-04

    This paper describes a microfluidic approach to perform multiplexed nanoliter-scale experiments by combining a sample with multiple different reagents, each at multiple mixing ratios. This approach employs a user-loaded, equipment-free SlipChip. The mixing ratios, characterized by diluting a fluorescent dye, could be controlled by the volume of each of the combined wells. The SlipChip design was validated on an {approx}12 nL scale by screening the conditions for crystallization of glutaryl-CoA dehydrogenase from Burkholderia pseudomallei against 48 different reagents; each reagent was tested at 11 different mixing ratios, for a total of 528 crystallization trials. The total consumption of the protein sample was {approx}10 {micro}L. Conditions for crystallization were successfully identified. The crystallization experiments were successfully scaled up in well plates using the conditions identified in the SlipChip. Crystals were characterized by X-ray diffraction and provided a protein structure in a different space group and at a higher resolution than the structure obtained by conventional methods. In this work, this user-loaded SlipChip has been shown to reliably handle fluids of diverse physicochemical properties, such as viscosities and surface tensions. Quantitative measurements of fluorescent intensities and high-resolution imaging were straighforward to perform in these glass SlipChips. Surface chemistry was controlled using fluorinated lubricating fluid, analogous to the fluorinated carrier fluid used in plug-based crystallization. Thus, we expect this approach to be valuable in a number of areas beyond protein crystallization, especially those areas where droplet-based microfluidic systems have demonstrated successes, including measurements of enzyme kinetics and blood coagulation, cell-based assays, and chemical reactions.

  17. Kinetic model for torrefaction of wood chips in a pilot-scale continuous reactor

    DEFF Research Database (Denmark)

    Shang, Lei; Ahrenfeldt, Jesper; Holm, Jens Kai;

    2014-01-01

    at different torrefaction temperatures, it was possible to predict the HHV of torrefied wood chips from the pilot reactor. The results from this study and the presented modeling approach can be used to predict the product quality from pilot scale torrefaction reactors based on small scale experiments...... temperature along the reactor and the biomass feeding rate in combination with the kinetic parameters obtained from the tests in the TGA. Together with results from a laboratory scale, batch torrefaction reactor that was used to determine the higher heating value (HHV) and mass loss (y) of the same material...

  18. Analytical investigation of the feasibility of sacrificial microchannel sealing for Chip-Scale Atomic Magnetometers

    OpenAIRE

    Tsujimoto, Kazuya; Hirai, Yoshikazu; Sugano, Koji; Tsuchiya, Toshiyuki; TABATA, Osamu

    2014-01-01

    An alkali metal vapor cell is a crucial component of the highly sensitive Chip Scale Atomic Magnetometers (CSAMs) that are increasingly deployed in a variety of electronic devices. Herein, we propose a novel microfabrication technique utilizing an array of microchannels at a bonded interface, to enable gas feedthrough for evacuation of unwanted gases from a vapor cell and subsequent introduction of an inert gas, followed by permanent sealing of the microchannels by reflow of a glass frit. The...

  19. Efficient large volume electroporation of dendritic cells through micrometer scale manipulation of flow in a disposable polymer chip

    DEFF Research Database (Denmark)

    Selmeczi, Dávid; Hansen, Thomas Steen; Met, Özcan; Svane, Inge Marie; Larsen, Niels Bent

    2011-01-01

    We present a hybrid chip of polymer and stainless steel designed for high-throughput continuous electroporation of cells in suspension. The chip is constructed with two parallel stainless steel mesh electrodes oriented perpendicular to the liquid flow. The relatively high hydrodynamic resistance of...... performance of the chip is similar to that of the traditional electroporation cuvette, but without an upper limit on the number of cells to be electroporated. The device is constructed with two female Luer parts and can easily be integrated with other microfluidic components. Furthermore it is fabricated from...... injection molded polymer parts and commercially available stainless steel mesh, making it suitable for inexpensive mass production....

  20. Chip-Scale Continuously Tunable Optical Orbital Angular Momentum Generator

    CERN Document Server

    Sun, Jie; Moresco, Michele; Coolbaugh, Douglas; Watts, Michael R

    2014-01-01

    Light carrying orbital angular momentum (OAM) has potential to impact a wide variety of applications ranging from optical communications to quantum information and optical forces for the excitation and manipulation of atoms, molecules, and micro-particles. The unique advantage of utilizing OAM in these applications relies, to a large extent, on the use of multiple different OAM states. Therefore, it is desirable to have a device that is able to gen- erate light with freely adjustable OAM states in an integrated form for large- scale integration. We propose and demonstrate a compact silicon photonic integrated circuit to generate a free-space optical beam with OAM state con- tinuously tuned from a single electrical input signal, realizing both integer and non-integer OAM states. The compactness and flexibility of the device and its compatibility with complementary metal-oxide-semiconductor (CMOS) pro- cessing hold promise for integration with other silicon photonic components for wide-ranging applications.

  1. Stabilized chip-scale Kerr frequency comb via a high-Q reference photonic microresonator

    Science.gov (United States)

    Lim, Jinkang; Huang, Shu-Wei; Vinod, Abhinav K.; Mortazavian, Parastou; Yu, Mingbin; Kwong, Dim-Lee; Savchenkov, Anatoliy A.; Matsko, Andrey B.; Maleki, Lute; Wong, Chee Wei

    2016-08-01

    We stabilize a chip-scale Si3N4 phase-locked Kerr frequency comb via locking the pump laser to an independent stable high-Q reference microresonator and locking the comb spacing to an external microwave oscillator. In this comb, the pump laser shift induces negligible impact on the comb spacing change. This scheme is a step towards miniaturization of the stabilized Kerr comb system as the microresonator reference can potentially be integrated on-chip. Fractional instability of the optical harmonics of the stabilized comb is limited by the microwave oscillator used for comb spacing lock below 1 s averaging time and coincides with the pump laser drift in the long term.

  2. A stabilized chip-scale Kerr frequency comb via a high-Q reference photonic microresonator

    CERN Document Server

    Lim, Jinkang; Vinod, Abhinav K; Mortazavian, Parastou; Yu, Mingbin; Kwong, Dim-Lee; Savchenkov, Anatoliy A; Matsko, Andrey B; Maleki, Lute; Wong, Chee Wei

    2016-01-01

    We stabilize a chip-scale Si3N4 phase-locked Kerr frequency comb via locking the pump laser to an independent stable high-Q reference microresonator and locking the comb spacing to an external microwave oscillator. In this comb, the pump laser shift induces negligible impact on the comb spacing change. This scheme is a step towards miniaturization of the stabilized Kerr comb system as the microresonator reference can potentially be integrated on-chip. Fractional instability of the optical harmonics of the stabilized comb is limited by the microwave oscillator used for comb spacing lock below 1 s averaging time and coincides with the pump laser drift in the long term.

  3. Nature-Inspired Interconnects for Self-Assembled Large-Scale Network-on-Chip Designs

    CERN Document Server

    Teuscher, Christof

    2007-01-01

    Future nano-scale electronics built up from an Avogadro number of components needs efficient, highly scalable, and robust means of communication in order to be competitive with traditional silicon approaches. In recent years, the Networks-on-Chip (NoC) paradigm emerged as a promising solution to interconnect challenges in silicon-based electronics. Current NoC architectures are either highly regular or fully customized, both of which represent implausible assumptions for emerging bottom-up self-assembled molecular electronics that are generally assumed to have a high degree of irregularity and imperfection. Here, we pragmatically and experimentally investigate important design trade-offs and properties of an irregular, abstract, yet physically plausible 3D small-world interconnect fabric that is inspired by modern network-on-chip paradigms. We vary the framework's key parameters, such as the connectivity, the number of switch nodes, the distribution of long- versus short-range connections, and measure the net...

  4. Growing length and time scales in glass-forming liquids

    OpenAIRE

    Karmakar, Smarajit; Dasgupta, Chandan; Sastry, Srikanth

    2009-01-01

    The glass transition, whereby liquids transform into amorphous solids at low temperatures, is a subject of intense research despite decades of investigation. Explaining the enormous increase in relaxation times of a liquid upon supercooling is essential for understanding the glass transition. Although many theories, such as the Adam–Gibbs theory, have sought to relate growing relaxation times to length scales associated with spatial correlations in liquid structure or motion of molecules, the...

  5. Development of the Large-Scale Oligonucleotide Chip for the Diagnosis of Plant Viruses and its Practical Use

    OpenAIRE

    Nam, Moon; Kim, Jeong-Seon; Lim, Seungmo; Park, Chung Youl; Kim, Jeong-Gyu; Choi, Hong-Soo; Lim, Hyoun-Sub; Moon, Jae Sun; Lee, Su-Heon

    2014-01-01

    A large-scale oligonucleotide (LSON) chip was developed for the detection of the plant viruses with known genetic information. The LSON chip contains two sets of 3,978 probes for 538 species of targets including plant viruses, satellite RNAs and viroids. A hundred forty thousand probes, consisting of isolate-, species- and genus-specific probes respectively, are designed from 20,000 of independent nucleotide sequence of plant viruses. Based on the economic importance, the amount of genome inf...

  6. Chip-Scale Nanofabrication of Single Spins and Spin Arrays in Diamond

    Energy Technology Data Exchange (ETDEWEB)

    Toyli, David M.; Weis, Christoph D.; Fuchs, D.; Schenkel, Thomas; Awschalom, David D.

    2010-07-02

    We demonstrate a technique to nanofabricate nitrogen vacancy (NV) centers in diamond based on broad-beam nitrogen implantation through apertures in electron beam lithography resist. This method enables high-throughput nanofabrication of single NV centers on sub-100-nm length scales. Secondary ion mass spectroscopy measurements facilitate depth profiling of the implanted nitrogen to provide three-dimensional characterization of the NV center spatial distribution. Measurements of NV center coherence with on-chip coplanar waveguides suggest a pathway for incorporating this scalable nanofabrication technique in future quantum applications.

  7. New Latency Model for Dynamic Frequency Scaling on Network-on-Chip

    Institute of Scientific and Technical Information of China (English)

    Sheng-Nan Li; Wen-Ming Pan

    2014-01-01

    Modulating both the clock frequency and supply voltage of the network-on-chip (NoC) during runtime can reduce the power consumption and heat flux, but will lead to the increase of the latency of NoC. It is necessary to find a tradeoff between power consumption and communication latency. So we propose an analytical latency model which can show us the relationship of them. The proposed model to analyze latency is based on the M/G/1 queuing model, which is suitable for dynamic frequency scaling. The experiment results show that the accuracy of this model is more than 90%.

  8. Surface Tension Directed Fluidic Self-Assembly of Semiconductor Chips across Length Scales and Material Boundaries

    Directory of Open Access Journals (Sweden)

    Shantonu Biswas

    2016-03-01

    Full Text Available This publication provides an overview and discusses some challenges of surface tension directed fluidic self-assembly of semiconductor chips which are transported in a liquid medium. The discussion is limited to surface tension directed self-assembly where the capture, alignment, and electrical connection process is driven by the surface free energy of molten solder bumps where the authors have made a contribution. The general context is to develop a massively parallel and scalable assembly process to overcome some of the limitations of current robotic pick and place and serial wire bonding concepts. The following parts will be discussed: (2 Single-step assembly of LED arrays containing a repetition of a single component type; (3 Multi-step assembly of more than one component type adding a sequence and geometrical shape confinement to the basic concept to build more complex structures; demonstrators contain (3.1 self-packaging surface mount devices, and (3.2 multi-chip assemblies with unique angular orientation. Subsequently, measures are discussed (4 to enable the assembly of microscopic chips (10 μm–1 mm; a different transport method is introduced; demonstrators include the assembly of photovoltaic modules containing microscopic silicon tiles. Finally, (5 the extension to enable large area assembly is presented; a first reel-to-reel assembly machine is realized; the machine is applied to the field of solid state lighting and the emerging field of stretchable electronics which requires the assembly and electrical connection of semiconductor devices over exceedingly large area substrates.

  9. Development of a Liquid Chip Technique to Simultaneously Detect Taura Syndrome Virus( TSV) and Yellow Head Disease Virus( YHDV)

    Institute of Scientific and Technical Information of China (English)

    Yin; Weili; Zhang; Sihua; Yue; Zhiqin; Zheng; Xiaolong; Liu; Hong

    2014-01-01

    The aim is to develop a liquid chip technique to detect Taura syndrome virus( TSV) and yellow head disease virus( YHDV) on Penaeus orientalis simultaneously. The CP2 gene of TSV and N gene of YHDV in Gen Bank was analysed by using the software DNAStar 7. 0 to design the TSV-and YHDV-specific primers. The primers were labeled with biotin and subjected to amination modification. They were then coupled with fluorescence-coded microspheres and then used for hybridization with RT- PCR products of TSV and YHDV. The liquid chip detection technique for detection of TSV and YHDV was established by using BD FACSArray to detect fluorescence signal in the reaction system. This assay system had a high sensitivity to TSV and YHDV,with the detection of limit of 100 pg. Moreover,the assay was specific for the detection of TSV,YHDV and was not susceptible to cross with other viruses,including white spot syndrome virus( WSSV),spring viremia of carp virus( SVCV),infectious haematopoietic necrosis virus( IHNV). In conclusion,the liquid chip assay technique established in this study is highly sensitive and specific to TSV and YHDV detection. Moreover,it provides a novel,convenient and rapid approach for the detection of TSV and YHDV.

  10. Fully Streched Single DNA Molecules in a Nanofluidic Chip Show Large-Scale Structural Variation

    DEFF Research Database (Denmark)

    Pedersen, Jonas Nyvold; Marie, Rodolphe; Bauer, D. L.;

    2013-01-01

    When stretching and imaging DNA molecules in nanofluidic devices, it is important to know the relation between the physical length as measured in the lab and the distance along the contour of the DNA. Here a single DNA molecule longer than 1 Mbp is loaded into a nanofluidic device consisting of two...... the contour length of the DNA, and (iii) without having the full DNA molecule inside the field-of-view. The analysis is based on the transverse motion of the DNA due its Brownian motion, i.e. the DNA's response to the thermal fluctuations of the liquid surrounding it. The parameter values obtained by fitting...... reflects the local AT/GC-content. Single molecules are loaded into the chip and imaged. Due to the almost complete stretching of the DNA, structural variations in the size range from kbp to Mbp can be detected and quantified from the melting pattern alone....

  11. Liquid-infiltrated photonic crystals - enhanced light-matter interactions for lab-on-a-chip applications

    OpenAIRE

    Mortensen, Niels Asger; Xiao, Sanshui; Pedersen, Jesper

    2007-01-01

    Optical techniques are finding widespread use in analytical chemistry for chemical and bio-chemical analysis. During the past decade, there has been an increasing emphasis on miniaturization of chemical analysis systems and naturally this has stimulated a large effort in integrating microfluidics and optics in lab-on-a-chip microsystems. This development is partly defining the emerging field of optofluidics. Scaling analysis and experiments have demonstrated the advantage of micro-scale devic...

  12. Network Partitioning Domain Knowledge Multiobjective Application Mapping for Large-Scale Network-on-Chip

    Directory of Open Access Journals (Sweden)

    Yin Zhen Tei

    2014-01-01

    Full Text Available This paper proposes a multiobjective application mapping technique targeted for large-scale network-on-chip (NoC. As the number of intellectual property (IP cores in multiprocessor system-on-chip (MPSoC increases, NoC application mapping to find optimum core-to-topology mapping becomes more challenging. Besides, the conflicting cost and performance trade-off makes multiobjective application mapping techniques even more complex. This paper proposes an application mapping technique that incorporates domain knowledge into genetic algorithm (GA. The initial population of GA is initialized with network partitioning (NP while the crossover operator is guided with knowledge on communication demands. NP reduces the large-scale application mapping complexity and provides GA with a potential mapping search space. The proposed genetic operator is compared with state-of-the-art genetic operators in terms of solution quality. In this work, multiobjective optimization of energy and thermal-balance is considered. Through simulation, knowledge-based initial mapping shows significant improvement in Pareto front compared to random initial mapping that is widely used. The proposed knowledge-based crossover also shows better Pareto front compared to state-of-the-art knowledge-based crossover.

  13. A chip tuneable laser developed for on-line micro–nano scale surface measurements

    International Nuclear Information System (INIS)

    The demand for accuracy and precision at the micro–nano level is constantly increasing in the manufacture of high added value products. This requires control and measurement of the surface structure since surface properties at such tiny scales are the dominant functional determinant. Many commercial instruments have been used for surface measurements. However, these devices are almost always operated in an off-line environment, and are not suitable for on-line application. This paper presents a new interferometry system consisting of a chip tuneable laser for future on-line micro–nano scale surface measurements. It is simple, compact and robust as most environmental noise and disturbance can be eliminated without any servo control system due to the near common path configuration and the compact construction. The experimental results show that this system has good performance, and there is scope to improve this if the performance of the laser is enhanced

  14. Large-field-of-view Chip-scale Talbot-grid-based Fluorescence Microscopy

    CERN Document Server

    Pang, Shuo; Kato, Mihoko; Sternberg, Paul W; Yang, Changhuei

    2012-01-01

    The fluorescence microscope is one of the most important tools in modern clinical diagnosis and biological science. However, its expense, size and limited field-of-view (FOV) are becoming bottlenecks in key applications such as large-scale phenotyping and low-resource-setting diagnostics. Here we report a low-cost, compact chip-scale fluorescence-imaging platform, termed the Fluorescence Talbot Microscopy (FTM), which utilizes the Talbot self-imaging effect to enable efficient fluorescence imaging over a large and directly-scalable FOV. The FTM prototype has a resolution of 1.2 microns and an FOV of 3.9 mm x 3.5 mm. We demonstrate the imaging capability of FTM on fluorescently labeled breast cancer cells (SK-BR-3) and HEK cells expressing green fluorescent protein.

  15. Validation and reliability assessment of board level drop test of chip-scale-packaging

    Science.gov (United States)

    Hung, Tuan-Yu; Chou, Chan-Yen; Yew, Ming-Chih; Chiang, Kuo-Ning

    2008-11-01

    The main objective of this study is to develop a stress-buffer-improved package that is subjected to a board level drop test under a specific-G impact level. In this regard, both the drop test experiment and the ANSYS/LS-DYNA simulations are carried out. Several studies have shown that the solder joints having the brittle intermetallic compound (IMC) layers within the wafer level chip scale packaging (WLCSP) are the weakest part. For the most part, this is due to the large relative motion occurring between the board and the chip. In addition, the stress buffer layer exhibiting a relatively large elongation which reduces the impact on the solder balls. Meanwhile, the novel stress-buffer-improve package's failure mode is different from the convention WLCSP structure which shifts to the trace damage of the chip side. The leading concern between the solder ball and trace damage is the critical region where failure occurred owing to the stress concentration effect. During the drop test experiment, the proposed stress-buffer-improved package is able to survive over 100 drops (most packages survived at above 200 drops). Hence, this drop performance very much surpasses the Joint Electron Device Engineering Council (JEDEC) criterion (drop number is 30 times). Nevertheless, the metal traces which are embedded in the stress buffer layer suffered relatively larger deformation. Generally, the stress concentration occurs at a single position, much like the trace/pad connecting junction in the analysis of detailed stress-buffer-improved package. Finally, the predict result in finite element (FE) analysis is similar to the broken metal trace's failure analysis in the drop test experiment.

  16. Density scaling as a property of strongly correlating viscous liquids

    OpenAIRE

    Schrøder, Thomas; Pedersen, Ulf Rørbæk; Bailey, Nicholas; Toxværd, Søren; Dyre, J.C.

    2008-01-01

    Results from molecular dynamics simulations of two viscous molecular model liquids -- the Lewis-Wahnstrom model of ortho-terphenyl and an asymmetric dumbbell model -- are reported. We demonstrate that the liquids have a ``hidden'' approximate scale invariance: Equilibrium potential energy fluctuations are accurately described by inverse power law (IPL) potentials, the radial distribution functions are accurately reproduced by the IPL's, and the radial distribution functions obey the IPL predi...

  17. Development of the large-scale oligonucleotide chip for the diagnosis of plant viruses and its practical use.

    Science.gov (United States)

    Nam, Moon; Kim, Jeong-Seon; Lim, Seungmo; Park, Chung Youl; Kim, Jeong-Gyu; Choi, Hong-Soo; Lim, Hyoun-Sub; Moon, Jae Sun; Lee, Su-Heon

    2014-03-01

    A large-scale oligonucleotide (LSON) chip was developed for the detection of the plant viruses with known genetic information. The LSON chip contains two sets of 3,978 probes for 538 species of targets including plant viruses, satellite RNAs and viroids. A hundred forty thousand probes, consisting of isolate-, species- and genus-specific probes respectively, are designed from 20,000 of independent nucleotide sequence of plant viruses. Based on the economic importance, the amount of genome information, and the number of strains and/or isolates, one to fifty-one probes for each target virus are selected and spotted on the chip. The standard and field samples for the analysis of the LSON chip have been prepared and tested by RT-PCR. The probe's specific and/or nonspecific reaction patterns by LSON chip allow us to diagnose the unidentified viruses. Thus, the LSON chip in this study could be highly useful for the detection of unexpected plant viruses, the monitoring of emerging viruses and the fluctuation of the population of major viruses in each plant. PMID:25288985

  18. On-chip purification via liquid immersion of arc-discharge synthesized multiwalled carbon nanotubes

    Science.gov (United States)

    Hokkanen, Matti J.; Lautala, Saara; Shao, Dongkai; Turpeinen, Tuomas; Koivistoinen, Juha; Ahlskog, Markus

    2016-07-01

    Arc-discharge synthesized multiwalled carbon nanotubes (AD-MWNT) have been proven to be of high quality, but their use is very limited due to difficulties in obtaining them in a clean and undamaged form. Here, we present a simple method that purifies raw AD-MWNT material in laboratory scale without damage, and that in principle can be scaled up. The method consists of depositing raw AD-MWNT material on a flat substrate and immersing the substrate slowly in water, whereby the surface tension force of the liquid-substrate contact line selectively sweeps away the larger amorphous carbon debris and leaves relatively clean MWNTs on the substrate. We demonstrate the utility of the method by preparing clean individual MWNTs for measurement of their Raman spectra. The spectra exhibit the characteristics of high-quality tubes free from contaminants. We also show how one concomitantly with the purification process can obtain large numbers of clean suspended MWNTs.

  19. Characterizations of ball impact responses of wafer-level chip-scale packages

    International Nuclear Information System (INIS)

    We present in this paper ball impact test results conducted on package-level 95.5Sn-4Ag-0.5Cu solder joints of a wafer-level chip-scale package, under an impact velocity of 1.4 m/s. Scanning electron microscopy was employed to investigate intermetallic morphologies and fractographs around the under bump metallurgy before and after the ball impact test, respectively. An explicit three-dimensional finite element analysis was also conducted and the comparison between computed and measured impact force profiles are presented. The comparison indicates that when material properties and strengths are apppropriately and reasonably selected, the finite element analysis is capable of capturing relevant ball impact test (BIT)-induced transient structural responses of the solder joint prior to the initiation of fracturing

  20. Sacrificial Microchannel Sealing by Glass-Frit Reflow for Chip Scale Atomic Magnetometer

    Science.gov (United States)

    Tsujimoto, Kazuya; Hirai, Yoshikazu; Sugano, Koji; Tsuchiya, Toshiyuki; Tabata, Osamu

    A novel sealing technique using sacrificial microchannels was proposed for atmosphere control in a micromachined alkali gas-filled cell for a chip scale atomic magnetometer. The microchannels act as feedthrough connecting the cell to outside atmosphere during evacuation and gas-filling steps, and eventually they are sealed by glass-frit reflow. Si microchannel dedicated as a sacrificial microchannel was proposed and its feasibility was successfully demonstrated by experiments. The simulation results clarified the glass-frit reflow characteristics and its dependence on cross-sectional shape of the microchannel. Hermeticity of the proposed sealing technique of less than 10-12Pa·m3/s leak rate was verified by a high resolution helium leak test.

  1. Review of chip-scale atomic clocks based on coherent population trapping

    International Nuclear Information System (INIS)

    Research on chip-scale atomic clocks (CSACs) based on coherent population trapping (CPT) is reviewed. The background and the inspiration for the research are described, including the important schemes proposed to improve the CPT signal quality, the selection of atoms and buffer gases, and the development of micro-cell fabrication. With regard to the reliability, stability, and service life of the CSACs, the research regarding the sensitivity of the CPT resonance to temperature and laser power changes is also reviewed, as well as the CPT resonance's collision and light of frequency shifts. The first generation CSACs have already been developed but its characters are still far from our expectations. Our conclusion is that miniaturization and power reduction are the most important aspects calling for further research. (review)

  2. Characterizations of ball impact responses of wafer-level chip-scale packages

    Energy Technology Data Exchange (ETDEWEB)

    Lai, Y.-S. [Stress-Reliability Laboratory, Advanced Semiconductor Engineering Inc., 26 Chin 3rd Road, Nantze Export Processing Zone, 811 Nantze, Kaohsiung, Taiwan (China)], E-mail: yishao_lai@aseglobal.com; Yeh, C.-L.; Chang, H.-C.; Kao, C.-L. [Stress-Reliability Laboratory, Advanced Semiconductor Engineering Inc., 26 Chin 3rd Road, Nantze Export Processing Zone, 811 Nantze, Kaohsiung, Taiwan (China)

    2008-02-14

    We present in this paper ball impact test results conducted on package-level 95.5Sn-4Ag-0.5Cu solder joints of a wafer-level chip-scale package, under an impact velocity of 1.4 m/s. Scanning electron microscopy was employed to investigate intermetallic morphologies and fractographs around the under bump metallurgy before and after the ball impact test, respectively. An explicit three-dimensional finite element analysis was also conducted and the comparison between computed and measured impact force profiles are presented. The comparison indicates that when material properties and strengths are apppropriately and reasonably selected, the finite element analysis is capable of capturing relevant ball impact test (BIT)-induced transient structural responses of the solder joint prior to the initiation of fracturing.

  3. Chip-scale fully reconfigurable optical add/drop multiplexing subsystem in polymer microphotonic circuits

    Science.gov (United States)

    Izuhara, Tomoyuki; Fujita, Junichiro; Radojevic, Antonije; Gerhardt, Reinald; Eldada, Louay A.

    2004-10-01

    We report on a highly integrated photonic circuit using a polymer-based planar waveguide system. The properties of the materials used in this work such as ultra-low optical loss, widely tunable refractive index, and large thermo-optic coefficient, enable a multi-functional chip-scale microphotonic circuit. We discuss the application of this technology to the fabrication of a fully reconfigurable optical add/drop multiplexer. This subsystem includes channel switching, power monitoring, load balancing, and wavelength shuffling functionalities that are required for agile wavelength-division multiplexing optical networks. Optical properties of our material systems and performance characteristics of the implemented optical passive/active elements are presented, and the integration schemes of the devices to achieve a fully integrated reconfigurable optical add/drop multiplexer are discussed.

  4. Liquid-infiltrated photonic crystals - enhanced light-matter interactions for lab-on-a-chip applications

    CERN Document Server

    Mortensen, Niels Asger; Pedersen, Jesper

    2007-01-01

    Optical techniques are finding widespread use in analytical chemistry for chemical and bio-chemical analysis. During the past decade, there has been an increasing emphasis on miniaturization of chemical analysis systems and naturally this has stimulated a large effort in integrating microfluidics and optics in lab-on-a-chip microsystems. This development is partly defining the emerging field of optofluidics. Scaling analysis and experiments have demonstrated the advantage of micro-scale devices over their macroscopic counterparts for a number of chemical applications. However, from an optical point of view, miniaturized devices suffer dramatically from the reduced optical path compared to macroscale experiments, e.g. in a cuvette. Obviously, the reduced optical path complicates the application of optical techniques in lab-on-a-chip systems. In this paper we theoretically discuss how a strongly dispersive photonic crystal environment may be used to enhance the light-matter interactions, thus potentially compen...

  5. A magnetic bead-integrated chip for the large scale manufacture of normalized esiRNAs.

    Directory of Open Access Journals (Sweden)

    Zhao Wang

    Full Text Available The chemically-synthesized siRNA duplex has become a powerful and widely used tool for RNAi loss-of-function studies, but suffers from a high off-target effect problem. Recently, endoribonulease-prepared siRNA (esiRNA has been shown to be an attractive alternative due to its lower off-target effect and cost effectiveness. However, the current manufacturing method for esiRNA is complicated, mainly in regards to purification and normalization on a large-scale level. In this study, we present a magnetic bead-integrated chip that can immobilize amplification or transcription products on beads and accomplish transcription, digestion, normalization and purification in a robust and convenient manner. This chip is equipped to manufacture ready-to-use esiRNAs on a large-scale level. Silencing specificity and efficiency of these esiRNAs were validated at the transcriptional, translational and functional levels. Manufacture of several normalized esiRNAs in a single well, including those silencing PARP1 and BRCA1, was successfully achieved, and the esiRNAs were subsequently utilized to effectively investigate their synergistic effect on cell viability. A small esiRNA library targeting 68 tyrosine kinase genes was constructed for a loss-of-function study, and four genes were identified in regulating the migration capability of Hela cells. We believe that this approach provides a more robust and cost-effective choice for manufacturing esiRNAs than current approaches, and therefore these heterogeneous RNA strands may have utility in most intensive and extensive applications.

  6. Highly sensitive optofluidic chips for biochemical liquid assay fabricated by 3D femtosecond laser micromachining followed by polymer coating.

    Science.gov (United States)

    Hanada, Yasutaka; Sugioka, Koji; Midorikawa, Katsumi

    2012-10-01

    The demand for increased sensitivity in the concentration analysis of biochemical liquids is a crucial issue in the development of lab on a chip and optofluidic devices. We propose a new design for optofluidic devices for performing highly sensitive biochemical liquid assays. This design consists of a microfluidic channel whose internal walls are coated with a polymer and an optical waveguide embedded in photostructurable glass. The microfluidic channel is first formed by three-dimensional femtosecond laser micromachining. The internal walls of the channel are then coated by the dipping method with a polymer that has a lower refractive index than water. Subsequently, the optical waveguide is integrated with the microfluidic channel. The polymer coating on the internal walls permits the probe light, which is introduced by the optical waveguide, to propagate along the inside of the microfluidic channel. This results in a sufficiently long interaction length between the probe light and a liquid sample in the channel and thus significantly improves the sensitivity of absorption measurements. Using the fabricated optofluidic chips, we analyzed protein in bovine serum albumin to concentrations down to 7.5 mM as well as 200 nM glucose-D. PMID:22814524

  7. High-Pressure Open-Channel On-Chip Electroosmotic Pump for Nanoflow High Performance Liquid Chromatography

    OpenAIRE

    Wang, Wei; Gu, Congying; Lynch, Kyle B.; Lu, Joann J.; Zhang, Zhengyu; Pu, Qiaosheng; Liu, Shaorong

    2014-01-01

    Here, we construct an open-channel on-chip electroosmotic pump capable of generating pressures up to ∼170 bar and flow rates up to ∼500 nL/min, adequate for high performance liquid chromatographic (HPLC) separations. A great feature of this pump is that a number of its basic pump units can be connected in series to enhance its pumping power; the output pressure is directly proportional to the number of pump units connected. This additive nature is excellent and useful, and no other pumps can ...

  8. Integrated chip-scale Si3N4 wavemeter with narrow free spectral range and high stability.

    Science.gov (United States)

    Xiang, Chao; Tran, Minh A; Komljenovic, Tin; Hulme, Jared; Davenport, Michael; Baney, Doug; Szafraniec, Bogdan; Bowers, John E

    2016-07-15

    We designed, fabricated, and characterized an integrated chip-scale wavemeter based on an unbalanced Mach-Zehnder interferometer with 300 MHz free spectral range. The wavemeter is realized in the Si3N4 platform, allowing for low loss with ∼62  cm of on-chip delay. We also integrated an optical hybrid to provide phase information. The main benefit of a fully integrated wavemeter, beside its small dimensions, is increased robustness to vibrations and temperature variations and much improved stability over fiber-based solutions. PMID:27420522

  9. Localization of burn mark under an abnormal topography on MOSFET chip surface using liquid crystal and emission microscopy tools.

    Science.gov (United States)

    Lau, C K; Sim, K S; Tso, C P

    2011-01-01

    This article focuses on the localization of burn mark in MOSFET and the scanning electron microscope (SEM) inspection on the defect location. When a suspect abnormal topography is shown on the die surface, further methods to pin-point the defect location is necessary. Fault localization analysis becomes important because an abnormal spot on the chip surface may and may not have a defect underneath it. The chip surface topography can change due to the catastrophic damage occurred at layers under the chip surface, but it could also be due to inconsistency during metal deposition in the wafer fabrication process. Two localization techniques, liquid crystal thermography and emission microscopy, were performed to confirm that the abnormal topography spot is the actual defect location. The tiny burn mark was surfaced by performing a surface decoration at the defect location using hot hydrochloric acid. SEM imaging, which has the high magnification and three-dimensional capabilities, was used to capture the images of the burn mark. PMID:21462221

  10. Thermal chip fabrication with arrays of sensors and heaters for micro-scale impingement cooling heat transfer analysis and measurements.

    Science.gov (United States)

    Shen, C H; Gau, C

    2004-07-30

    The design and fabrication for a thermal chip with an array of temperature sensors and heaters for study of micro-jet impingement cooling heat transfer process are presented. This thermal chip can minimize the heat loss from the system to the ambient and provide a uniform heat flux along the wall, thus local heat transfer processes along the wall can be measured and obtained. The fabrication procedure presented can reach a chip yield of 100%, and every one of the sensors and heaters on the chip is in good condition. In addition, micro-jet impingement cooling experiments are performed to obtain the micro-scale local heat transfer Nusselt number along the wall. Flow visualization for the micro-impinging jet is also made. The experimental results indicate that both the micro-scale impinging jet flow structure and the heat transfer process along the wall is significantly different from the case of large-scale jet impingement cooling process. PMID:15142582

  11. Non-Fermi Liquid Scaling in CeRhSn

    International Nuclear Information System (INIS)

    We have recently shown that CeRhSn exhibits non-Fermi liquid temperature dependences in its low-temperature physical properties. Here we suggest that the non-Fermi liquid behavior observed in CeRhSn may be due to the existence of a Griffiths phase in the vicinity of a quantum critical point, based on electrical resistivity, magnetic susceptibility , and specific heat measurements. For CeRhSn, the low-temperature scaling of bulk properties (C/T ∝ χ ∝ T-1+λ, where λ<1) is masked by an anomaly at about 6 K, which is of magnetic origin. (author)

  12. Development of a small-scale protope of the GOSSIPO-2 chip in 0.13 um CMOS technology

    CERN Document Server

    Kluit, R; Gromov, V

    2007-01-01

    The GOSSIP (Gas On Slimmed Silicon Pixel) detector is a proposed alternative for silicon based pixel detectors. The Gossip Prototype (GOSSIPO) chip is being developed to serve as a prototype read-out chip for such a gas-filled detector. Thanks to the very low capacitance at the preamplifier input, the front-end of the chip demonstrates low-noise performance in combination with a fast peaking time and low analog power dissipation. Measurement of the drift time of every primary electron in the gas volume enables 3D reconstruction of the particle tracks. For this purpose a Time-to- Digital converter must be placed in each pixel. A small-scale prototype of the GOSSIP chip has been developed in the 0.13 μm CMOS technology. The prototype includes a 16 by 16 pixel array where each pixel is equipped with a front-end circuit, threshold DAC, and a 4-bit TDC. The chip is available for testing in May 2007 and after initial tests it will be postprocessed to build a prototype detector. This paper describes the detector de...

  13. Experimental assessment of on-chip liquid cooling through microchannels with de-ionized water and diluted ethylene glycol

    Science.gov (United States)

    Won, Yonghyun; Kim, Sungdong; Eunkyung Kim, Sarah

    2016-06-01

    Recent progress in Si IC devices, which results in an increase in power density and decrease in device size, poses various thermal challenges owing to high heat dissipation. Therefore, conventional cooling techniques become ineffective and produce a thermal bottleneck. In this study, an on-chip liquid cooling module with microchannels and through Si via (TSV) was fabricated, and cooling characteristics were evaluated by IR measurements. Both the microchannels and TSVs were fabricated in a Si wafer by deep reactive ion etching (DRIE) and the wafer was bonded with a glass wafer by a anodic bonding. The fabricated liquid cooling sample was evaluated using two different coolants (de-ionized water and 70 wt % diluted ethylene glycol), and the effect of coolants on cooling characteristics was investigated.

  14. Refractive index-based detection of gradient elution liquid chromatography using chip-integrated microring resonator arrays.

    Science.gov (United States)

    Wade, James H; Bailey, Ryan C

    2014-01-01

    Refractive index-based sensors offer attractive characteristics as nondestructive and universal detectors for liquid chromatographic separations, but a small dynamic range and sensitivity to minor thermal perturbations limit the utility of commercial RI detectors for many potential applications, especially those requiring the use of gradient elutions. As such, RI detectors find use almost exclusively in sample abundant, isocratic separations when interfaced with high-performance liquid chromatography. Silicon photonic microring resonators are refractive index-sensitive optical devices that feature good sensitivity and tremendous dynamic range. The large dynamic range of microring resonators allows the sensors to function across a wide spectrum of refractive indices, such as that encountered when moving from an aqueous to organic mobile phase during a gradient elution, a key analytical advantage not supported in commercial RI detectors. Microrings are easily configured into sensor arrays, and chip-integrated control microrings enable real-time corrections of thermal drift. Thermal controls allow for analyses at any temperature and, in the absence of rigorous temperature control, obviates extended detector equilibration wait times. Herein, proof of concept isocratic and gradient elution separations were performed using well-characterized model analytes (e.g., caffeine, ibuprofen) in both neat buffer and more complex sample matrices. These experiments demonstrate the ability of microring arrays to perform isocratic and gradient elutions under ambient conditions, avoiding two major limitations of commercial RI-based detectors and maintaining comparable bulk RI sensitivity. Further benefit may be realized in the future through selective surface functionalization to impart degrees of postcolumn (bio)molecular specificity at the detection phase of a separation. The chip-based and microscale nature of microring resonators also make it an attractive potential detection

  15. CMOS VLSI pilot and support chip for a liquid crystal on silicon 8x8 optical cross connect

    Science.gov (United States)

    Lelah, Alan; Vinouze, Bruno; Martel, Gilbert; Perez-Segovia, Tomas; Geoffroy, Philippe; Laval, Jean-Paul; Jayet, Philippe; Senn, Patrice; Gravey, Philippe; Wolffer, Nicole; Lever, Roger; Tan, Antione

    2001-12-01

    With the explosion of Internet and multi-service traffic, telecommunication transport networks today are turning to Wavelength Division Multiplexing. Optical cross-connects (OXCs) allow flexible rerouting of wavelength channels. It has been shown that 2-D free-space beam deflection by nematic liquid crystal gratings provide a good solution for the realization of optical switches in OXCs. Operating in the telecom 1.5 micrometers wavelength region they serve as an active holographic element. Liquid Crystal on Silicon (LCOS) combined with VLSI technologies allow the fabrication of large capacity, low cost and low consumption compact free-space switches. An N X N optical switch can be built by cascading two LCOS-based spatial light modulators (SLMs). The first part of the paper describes a circuit that provides the physical support as well as piloting circuitry for such SLMs. It is capable of piloting beams from a linear array of 8 incoming fibers towards a similar array of 8 outgoing fibers. The electrode command voltages are analog while the external interface as well as on-chip memory is digital. The chip has been implemented in a CMOS 0.5 (mu) process with 600,000 transistors while die size is 320 mm2 (80 mm2 active area).

  16. Quantitative determination of 8-isoprostaglandin F(2α) in human urine using microfluidic chip-based nano-liquid chromatography with on-chip sample enrichment and tandem mass spectrometry.

    Science.gov (United States)

    Bai, Hsin-Yu; Lin, Shu-Ling; Chung, Yu-Ting; Liu, Tsung-Yun; Chan, Shan-An; Fuh, Ming-Ren

    2011-04-15

    Urinary 8-isoprostaglandin F(2α) (8-isoPGF(2α)) has been reported as an important biomarker to indicate the oxidative stress status in vivo. In order to quantitatively determine the low contents of 8-isoPGF(2α) (in sub- to low ng mL(-1) range) in physiological fluids, a sensitive detection method has become an important issue. In this study, we employed a microfluidic chip-based nano liquid chromatography (chip-nanoLC) with on-chip sample enrichment coupled to triple quadrupole mass spectrometer (QqQ-MS) for the quantitative determination of 8-isoPGF(2α) in human urine. This chip-nanoLC unit integrates a microfluidic switch, a chip column design having a pre-column (enrichment column) for sample enrichment prior to an analytical column for separation, as well as a nanospray emitter on a single polyimide chip. The introduction of enrichment column offers the advantages of online sample pre-concentration and reducing matrix influence on MS detection to improve sensitivity. In this study, the chip-nanoLC consisting of Zorbax 300A SB-C18 columns and Agilent QqQ Mass spectrometer were used for determining 8-isoPGF(2α) in human urine. Gradient elution was employed for effective LC separation and multiple reaction monitoring (MRM) was utilized for the quantitative determination of 8-isoPGF(2α) (m/z 353→193). We employed liquid-liquid extraction (LLE)/solid-phase extraction (SPE) for extracting analyte and reducing matrix effect from urine sample prior to chip-nanoLC/QqQ-MS analysis for determining urinary 8-isoPGF(2α). Good recoveries were found to be in the range of 83.0-85.3%. The linear range was 0.01-2 ng mL(-1) for urinary 8-isoPGF(2α). In addition, the proposed method showed good precision and accuracy for 8-isoPGF(2α) spiked synthetic urine samples. Intra-day and inter-day precisions were 1.8-5.0% and 4.3-5.8%, respectively. The method accuracy for intra-day and inter-day assays ranged from 99.3 to 99.9% and 99.4 to 99.7%, respectively. Due to its

  17. Characterization of aqueous two phase systems by combining lab-on-a-chip technology with robotic liquid handling stations.

    Science.gov (United States)

    Amrhein, Sven; Schwab, Marie-Luise; Hoffmann, Marc; Hubbuch, Jürgen

    2014-11-01

    Over the last decade, the use of design of experiment approaches in combination with fully automated high throughput (HTP) compatible screenings supported by robotic liquid handling stations (LHS), adequate fast analytics and data processing has been developed in the biopharmaceutical industry into a strategy of high throughput process development (HTPD) resulting in lower experimental effort, sample reduction and an overall higher degree of process optimization. Apart from HTP technologies, lab-on-a-chip technology has experienced an enormous growth in the last years and allows further reduction of sample consumption. A combination of LHS and lab-on-a-chip technology is highly desirable and realized in the present work to characterize aqueous two phase systems with respect to tie lines. In particular, a new high throughput compatible approach for the characterization of aqueous two phase systems regarding tie lines by exploiting differences in phase densities is presented. Densities were measured by a standalone micro fluidic liquid density sensor, which was integrated into a liquid handling station by means of a developed generic Tip2World interface. This combination of liquid handling stations and lab-on-a-chip technology enables fast, fully automated, and highly accurate density measurements. The presented approach was used to determine the phase diagram of ATPSs composed of potassium phosphate (pH 7) and polyethylene glycol (PEG) with a molecular weight of 300, 400, 600 and 1000 Da respectively in the presence and in the absence of 3% (w/w) sodium chloride. Considering the whole ATPS characterization process, two complete ATPSs could be characterized within 24h, including four runs per ATPS for binodal curve determination (less than 45 min/run), and tie line determination (less than 45 min/run for ATPS preparation and 8h for density determination), which can be performed fully automated over night without requiring man power. The presented methodology provides

  18. Studies of intensified small-scale processes for liquid-liquid separations in spent nuclear fuel reprocessing

    OpenAIRE

    Tsaoulidis, D.

    2014-01-01

    The main contribution of the thesis is to study and develop small-scale processes for ionic liquid-based extractions that can intensify the liquid-liquid separations in the spent nuclear fuel reprocessing cycle. The industrial application of small scale processes requires that their hydrodynamics and mass transfer behaviour are well characterised and predicted. In addition, modelling methodologies are proposed to evaluate the applicability of the small scale extractors in reprocessing the lar...

  19. A broadband chip-scale optical frequency synthesizer at 2.7 × 10−16 relative uncertainty

    OpenAIRE

    Huang, Shu-Wei; Yang, Jinghui; Yu, Mingbin; McGuyer, Bart H.; Kwong, Dim-Lee; Zelevinsky, Tanya; Wong, Chee Wei

    2016-01-01

    Optical frequency combs—coherent light sources that connect optical frequencies with microwave oscillations—have become the enabling tool for precision spectroscopy, optical clockwork, and attosecond physics over the past decades. Current benchmark systems are self-referenced femtosecond mode-locked lasers, but Kerr nonlinear dynamics in high-Q solid-state microresonators has recently demonstrated promising features as alternative platforms. The advance not only fosters studies of chip-scale ...

  20. Development of 3D human intestinal equivalents for substance testing in microliter-scale on a multi-organ-chip

    OpenAIRE

    Jaenicke, Annika; Tordy, Dominique; Groeber, Florian; Hansmann, Jan; Nietzer, Sarah; Tripp, Carolin; Walles, Heike; Lauster, Roland; Marx, Uwe

    2013-01-01

    First published by BioMed Central: Jaenicke, Annika; Tordy, Dominique; Groeber, Florian; Hansmann, Jan; Nietzer, Sarah; Tripp, Carolin; Walles, Heike; Lauster, Roland; Marx, Uwe: Development of 3D human intestinal equivalents for substance testing in microliter-scale on a multi-organ-chip. - In: BMC Proceedings. - ISSN 1753-6561 (online). - 7 (2013), suppl. 6, P65. - doi:10.1186/1753-6561-7-S6-P65.

  1. The Atomic scale structure of liquid metal-electrolyte interfaces.

    Science.gov (United States)

    Murphy, B M; Festersen, S; Magnussen, O M

    2016-08-01

    Electrochemical interfaces between immiscible liquids have lately received renewed interest, both for gaining fundamental insight as well as for applications in nanomaterial synthesis. In this feature article we demonstrate that the atomic scale structure of these previously inaccessible interfaces nowadays can be explored by in situ synchrotron based X-ray scattering techniques. Exemplary studies of a prototypical electrochemical system - a liquid mercury electrode in pure NaCl solution - reveal that the liquid metal is terminated by a well-defined atomic layer. This layering decays on length scales of 0.5 nm into the Hg bulk and displays a potential and temperature dependent behaviour that can be explained by electrocapillary effects and contributions of the electronic charge distribution on the electrode. In similar studies of nanomaterial growth, performed for the electrochemical deposition of PbFBr, a complex nucleation and growth behaviour is found, involving a crystalline precursor layer prior to the 3D crystal growth. Operando X-ray scattering measurements provide detailed data on the processes of nanoscale film formation. PMID:27301317

  2. The Atomic scale structure of liquid metal-electrolyte interfaces

    Science.gov (United States)

    Murphy, B. M.; Festersen, S.; Magnussen, O. M.

    2016-07-01

    Electrochemical interfaces between immiscible liquids have lately received renewed interest, both for gaining fundamental insight as well as for applications in nanomaterial synthesis. In this feature article we demonstrate that the atomic scale structure of these previously inaccessible interfaces nowadays can be explored by in situ synchrotron based X-ray scattering techniques. Exemplary studies of a prototypical electrochemical system - a liquid mercury electrode in pure NaCl solution - reveal that the liquid metal is terminated by a well-defined atomic layer. This layering decays on length scales of 0.5 nm into the Hg bulk and displays a potential and temperature dependent behaviour that can be explained by electrocapillary effects and contributions of the electronic charge distribution on the electrode. In similar studies of nanomaterial growth, performed for the electrochemical deposition of PbFBr, a complex nucleation and growth behaviour is found, involving a crystalline precursor layer prior to the 3D crystal growth. Operando X-ray scattering measurements provide detailed data on the processes of nanoscale film formation.

  3. Liquid-infiltrated photonic crystals for lab-on-a-chip applications

    DEFF Research Database (Denmark)

    Xiao, Sanshui; Pedersen, Jesper; Mortensen, Niels Asger

    2007-01-01

    In this paper we theoretically discuss how a strongly dispersive photonic crystals environment may be used to enhance the light-matter interactions, thus potentially compensating for the reduced optical path in typical lab-on- a-chip systems. Combining electromagnetic perturbation theory with ful......-wave electromagnetic simulations we address the prospects for slow-light enhancement of Beer-Lambert absorption and photonic band-gap based refractometry....

  4. Patterns on liquid surfaces cnoidal waves, compactons and scaling

    CERN Document Server

    Ludu, A; Ludu, Andrei; Draayer, Jerry P.

    1998-01-01

    Localized patterns and nonlinear oscillation formation on the bounded free surface of an ideal incompressible liquid are analytically investigated . Cnoidal modes, solitons and compactons, as traveling non-axially symmetric shapes are discused. A finite-difference differential generalized Korteweg-de Vries equation is shown to describe the three-dimensional motion of the fluid surface and the limit of long and shallow channels one reobtains the well known KdV equation. A tentative expansion formula for the representation of the general solution of a nonlinear equation, for given initial condition is introduced on a graphical-algebraic basis. The model is useful in multilayer fluid dynamics, cluster formation, and nuclear physics since, up to an overall scale, these systems display liquid free surface behavior.

  5. Large-Scale, Highly Efficient, and Green Liquid-Exfoliation of Black Phosphorus in Ionic Liquids.

    Science.gov (United States)

    Zhao, Wancheng; Xue, Zhimin; Wang, Jinfang; Jiang, Jingyun; Zhao, Xinhui; Mu, Tiancheng

    2015-12-23

    We developed a facile, large-scale, and environmentally friendly liquid-exfoliation method to produce stable and high-concentration dispersions of mono- to few-layer black phosphorus (BP) nanosheets from bulk BP using nine ionic liquids. The prepared suspensions can stabilize without any obvious sedimentation and aggregation in ambient air for one month. In particular, the concentration (up to 0.95 mg mL(-1)) of BP nanoflakes obtained in 1-hydroxyethyl-3-methylimidazolium trifluoromethansulfonate ([HOEMIM][TfO]) is the highest reported for BP nanosheets dispersions. This work provides new opportunities for preparing atomically thin BP nanosheets in green, large-scale, and highly concentrated processes and achieving its in situ application. PMID:26642883

  6. Comprehensive Investigation on Current Imbalance among Parallel Chips inside MW-Scale IGBT Power Modules

    DEFF Research Database (Denmark)

    Wu, Rui; Smirnova, Liudmila; Wang, Huai;

    2015-01-01

    With the demands for increasing the power rating and improving reliability level of the high power IGBT modules, there are further needs of understanding how to achieve stable paralleling and identical current sharing between the chips. This paper investigates the stray parameters imbalance among...... parallel chips inside the 1.7 kV/1 kA high power IGBT modules at different frequencies by Ansys Q3D parastics extractor. The resulted current imbalance is further confirmed by experimental measurement....

  7. Comprehensive Investigation on Current Imbalance among Parallel Chips inside MW-Scale IGBT Power Modules

    OpenAIRE

    Wu, Rui; Smirnova, Liudmila; Wang, Huai; Iannuzzo, Francesco; Blaabjerg, Frede

    2015-01-01

    With the demands for increasing the power rating and improving reliability level of the high power IGBT modules, there are further needs of understanding how to achieve stable paralleling and identical current sharing between the chips. This paper investigates the stray parameters imbalance among parallel chips inside the 1.7 kV/1 kA high power IGBT modules at different frequencies by Ansys Q3D parastics extractor. The resulted current imbalance is further confirmed by experimental measurement.

  8. Reliability and Characteristics of Wafer-Level Chip-Scale Packages under Current Stress

    Science.gov (United States)

    Chen, Po-Ying; Kung, Heng-Yu; Lai, Yi-Shao; Hsiung Tsai, Ming; Yeh, Wen-Kuan

    2008-02-01

    In this work, we present a novel approach and method for elucidating the characteristics of wafer-level chip-scale packages (WLCSPs) for electromigration (EM) tests. The die in WLCSP was directly attached to the substrate via a soldered interconnect. The shrinking of the area of the die that is available for power, and the solder bump also shrinks the volume and increases the density of electrons for interconnect efficiency. The bump current density now approaches to 106 A/cm2, at which point the EM becomes a significant reliability issue. As known, the EM failure depends on numerous factors, including the working temperature and the under bump metallization (UBM) thickness. A new interconnection geometry is adopted extensively with moderate success in overcoming larger mismatches between the displacements of components during current and temperature changes. Both environments and testing parameters for WLCSP are increasingly demanded. Although failure mechanisms are considered to have been eliminated or at least made manageable, new package technologies are again challenging its process, integrity and reliability. WLCSP technology was developed to eliminate the need for encapsulation to ensure compatibility with smart-mount technology (SMT). The package has good handing properties but is now facing serious reliability problems. In this work, we investigated the reliability of a WLCSP subjected to different accelerated current stressing conditions at a fixed ambient temperature of 125 °C. A very strong correlation exists between the mean time to failure (MTTF) of the WLCSP test vehicle and the mean current density that is carried by a solder joint. A series of current densities were applied to the WLCSP architecture; Black's power law was employed in a failure mode simulation. Additionally, scanning electron microscopy (SEM) was adopted to determine the differences existing between high- and low-current-density failure modes.

  9. Chip-Scale Bioassays Based on Surface-Enhanced Raman Scattering: Fundamentals and Applications

    Energy Technology Data Exchange (ETDEWEB)

    Hye-Young Park

    2005-12-17

    This work explores the development and application of chip-scale bioassays based on surface-enhanced Raman scattering (SERS) for high throughput and high sensitivity analysis of biomolecules. The size effect of gold nanoparticles on the intensity of SERS is first presented. A sandwich immunoassay was performed using Raman-labeled immunogold nanoparticles with various sizes. The SERS responses were correlated to particle densities, which were obtained by atomic force microscopy (AFM). The response of individual particles was also investigated using Raman-microscope and an array of gold islands on a silicon substrate. The location and the size of individual particles were mapped using AFM. The next study describes a low-level detection of Escherichia coli 0157:H7 and simulants of biological warfare agents in a sandwich immunoassay format using SERS labels, which have been termed Extrinsic Raman labels (ERLs). A new ERL scheme based on a mixed monolayer is also introduced. The mixed monolayer ERLs were created by covering the gold nanoparticles with a mixture of two thiolates, one thiolate for covalently binding antibody to the particle and the other thiolate for producing a strong Raman signal. An assay platform based on mixed self-assembled monolayers (SAMs) on gold is then presented. The mixed SAMs were prepared from dithiobis(succinimidyl undecanoate) (DSU) to covalently bind antibodies on gold substrate and oligo(ethylene glycol)-terminated thiol to prevent nonspecific adsorption of antibodies. After the mixed SAMs surfaces, formed from various mole fraction of DSU were incubated with antibodies, AFM was used to image individual antibodies on the surface. The final study presents a collaborative work on the single molecule adsorption of YOYO-I labeled {lambda}-DNA at compositionally patterned SAMs using total internal reflection fluorescence microscopy. The role of solution pH, {lambda}-DNA concentration, and domain size was investigated. This work also revealed

  10. Estimating the density scaling exponent of viscous liquids from specific heat and bulk modulus data

    OpenAIRE

    Pedersen, Ulf R.; Hecksher, Tina; Jakobsen, Bo; Schrøder, Thomas B.; Gnan, Nicoletta; Bailey, Nicholas P.; Dyre, Jeppe C.

    2009-01-01

    It was recently shown by computer simulations that a large class of liquids exhibits strong correlations in their thermal fluctuations of virial and potential energy [Pedersen et al., Phys. Rev. Lett. 100, 015701 (2008)]. Among organic liquids the class of strongly correlating liquids includes van der Waals liquids, but excludes ionic and hydrogen-bonding liquids. The present note focuses on the density scaling of strongly correlating liquids, i.e., the fact their relaxation time tau at diffe...

  11. Dynamic Scaling of Ramified Clusters Formed on Liquid Surfaces

    Institute of Scientific and Technical Information of China (English)

    WU Feng-Min; XU You-Sheng; LI Qiao-Wen

    2006-01-01

    A comprehensive simulation model -deposition,diffusion, rotation, reaction and aggregation model is presented to simulate the formation processes of ramified clusters on liquid surfaces, where clusters can diffuse and rotate easily. The mobility (including diffusion and rotation) of clusters is related to its mass, which is given by Dm = Dos-γD and θm =′θos-γθ, respectively. The influence of the reaction probability on the kinetics and structure formation is included in the simulation model. We concentrate on revealing dynamic scaling during ramified cluster formation. For this purpose, the time evolution of the cluster density and the weight-average cluster size as well as the cluster-size distribution scaling function at different time are determined for various conditions. The dependence of the cluster density on the deposition flux and time-dependence of fractal dimension are also investigated. The obtained results are helpful in understanding the formation of clusters or thin film growth on liquid surfaces.

  12. Liquid carry-over in an injection moulded all-polymer chip system for immiscible phase magnetic bead-based solid-phase extraction

    International Nuclear Information System (INIS)

    We present an all-polymer, single-use microfluidic chip system produced by injection moulding and bonded by ultrasonic welding. Both techniques are compatible with low-cost industrial mass-production. The chip is produced for magnetic bead-based solid-phase extraction facilitated by immiscible phase filtration and features passive liquid filling and magnetic bead manipulation using an external magnet. In this work, we determine the system compatibility with various surfactants. Moreover, we quantify the volume of liquid co-transported with magnetic bead clusters from Milli-Q water or a lysis-binding buffer for nucleic acid extraction (0.1 (v/v)% Triton X-100 in 5 M guanidine hydrochloride). A linear relationship was found between the liquid carry-over and mass of magnetic beads used. Interestingly, similar average carry-overs of 1.74(8) nL/µg and 1.72(14) nL/µg were found for Milli-Q water and lysis-binding buffer, respectively. - Highlights: • We present an all-polymer mass producible passive filled microfluidic chip system. • Rapid system fabrication is obtained by injection moulding and ultrasonic welding. • The system is made for single-use nucleic acid extraction using magnetic beads. • We systematically map compatibility of the chip system with various surfactants. • We quantify the volume carry-over of magnetic beads in water and 0.1% triton-X solution

  13. Liquid carry-over in an injection moulded all-polymer chip system for immiscible phase magnetic bead-based solid-phase extraction

    Energy Technology Data Exchange (ETDEWEB)

    Kistrup, Kasper, E-mail: kkis@nanotech.dtu.dk [Department of Micro- and Nanotechnology, Technical University of Denmark, DTU Nanotech, Building 345 East, DK-2800 Kongens Lyngby (Denmark); Skotte Sørensen, Karen, E-mail: karen@nanotech.dtu.dk [Department of Micro- and Nanotechnology, Technical University of Denmark, DTU Nanotech, Building 345 East, DK-2800 Kongens Lyngby (Denmark); Center for Integrated Point of Care Technologies (CiPoC), DELTA, Venlighedsvej 4, DK-2870 Hørsholm (Denmark); Wolff, Anders, E-mail: anders.wolff@nanotech.dtu.dk [Department of Micro- and Nanotechnology, Technical University of Denmark, DTU Nanotech, Building 345 East, DK-2800 Kongens Lyngby (Denmark); Fougt Hansen, Mikkel, E-mail: mikkel.hansen@nanotech.dtu.dk [Department of Micro- and Nanotechnology, Technical University of Denmark, DTU Nanotech, Building 345 East, DK-2800 Kongens Lyngby (Denmark)

    2015-04-15

    We present an all-polymer, single-use microfluidic chip system produced by injection moulding and bonded by ultrasonic welding. Both techniques are compatible with low-cost industrial mass-production. The chip is produced for magnetic bead-based solid-phase extraction facilitated by immiscible phase filtration and features passive liquid filling and magnetic bead manipulation using an external magnet. In this work, we determine the system compatibility with various surfactants. Moreover, we quantify the volume of liquid co-transported with magnetic bead clusters from Milli-Q water or a lysis-binding buffer for nucleic acid extraction (0.1 (v/v)% Triton X-100 in 5 M guanidine hydrochloride). A linear relationship was found between the liquid carry-over and mass of magnetic beads used. Interestingly, similar average carry-overs of 1.74(8) nL/µg and 1.72(14) nL/µg were found for Milli-Q water and lysis-binding buffer, respectively. - Highlights: • We present an all-polymer mass producible passive filled microfluidic chip system. • Rapid system fabrication is obtained by injection moulding and ultrasonic welding. • The system is made for single-use nucleic acid extraction using magnetic beads. • We systematically map compatibility of the chip system with various surfactants. • We quantify the volume carry-over of magnetic beads in water and 0.1% triton-X solution.

  14. Characterization and modeling of two-phase heat transfer in chip-scale non-uniformly heated microgap channels

    Science.gov (United States)

    Ali, Ihab A.

    A chip-scale, non-uniformly heated microgap channel, 100 micron to 500 micron in height with dielectric fluid HFE-7100 providing direct single- and two-phase liquid cooling for a thermal test chip with localized heat flux reaching 100 W/cm2, is experimentally characterized and numerically modeled. Single-phase heat transfer and hydraulic characterization is performed to establish the single-phase baseline performance of the microgap channel and to validate the mesh-intensive CFD numerical model developed for the test channel. Convective heat transfer coefficients for HFE-7100 flowing in a 100-micron microgap channel reached 9 kW/m2K at 6.5 m/s fluid velocity. Despite the highly non-uniform boundary conditions imposed on the microgap channel, CFD model simulation gave excellent agreement with the experimental data (to within 5%), while the discrepancy with the predictions of the classical, "ideal" channel correlations in the literature reached 20%. A detailed investigation of two-phase heat transfer in non-ideal micro gap channels, with developing flow and significant non-uniformities in heat generation, was performed. Significant temperature non-uniformities were observed with non-uniform heating, where the wall temperature gradient exceeded 30°C with a heat flux gradient of 3-30 W/cm2, for the quadrant-die heating pattern compared to a 20°C gradient and 7-14 W/cm2 heat flux gradient for the uniform heating pattern, at 25W heat and 1500 kg/m2s mass flux. Using an inverse computation technique for determining the heat flow into the wetted microgap channel, average wall heat transfer coefficients were found to vary in a complex fashion with channel height, flow rate, heat flux, and heating pattern and to typically display an inverse parabolic segment of a previously observed M-shaped variation with quality, for two-phase thermal transport. Examination of heat transfer coefficients sorted by flow regimes yielded an overall agreement of 31% between predictions of the

  15. Characterization of goat colostrum oligosaccharides by nano-liquid chromatography on chip quadrupole time-of-flight mass spectrometry and hydrophilic interaction liquid chromatography-quadrupole mass spectrometry.

    Science.gov (United States)

    Martín-Ortiz, A; Salcedo, J; Barile, D; Bunyatratchata, A; Moreno, F J; Martin-García, I; Clemente, A; Sanz, M L; Ruiz-Matute, A I

    2016-01-01

    A detailed qualitative and quantitative characterization of goat colostrum oligosaccharides (GCO) has been carried out for the first time. Defatted and deproteinized colostrum samples, previously treated by size exclusion chromatography (SEC) to remove lactose, were analyzed by nanoflow liquid chromatography-quadrupole-time of flight mass spectrometry (Nano-LC-Chip-Q-TOF MS). Up to 78 oligosaccharides containing hexose, hexosamine, fucose, N-acetylneuraminic acid or N-glycolylneuraminic acid monomeric units were identified in the samples, some of them detected for the first time in goat colostra. As a second step, a hydrophilic interaction liquid chromatography coupled to mass spectrometry (HILIC-MS) methodology was developed for the separation and quantitation of the main GCO, both acidic and neutral carbohydrates. Among other experimental chromatographic conditions, mobile phase additives and column temperature were evaluated in terms of retention time, resolution, peak width and symmetry of target carbohydrates. Narrow peaks (wh: 0.2-0.6min) and good symmetry (As: 0.8-1.4) were obtained for GCO using an acetonitrile:water gradient with 0.1% ammonium hydroxide at 40°C. These conditions were selected to quantify the main oligosaccharides in goat colostrum samples. Values ranging from 140 to 315mgL(-1) for neutral oligosaccharides and from 83 to 251mgL(-1) for acidic oligosaccharides were found. The combination of both techniques resulted to be useful to achieve a comprehensive characterization of GCO. PMID:26427327

  16. Thermally triggered phononic gaps in liquids at THz scale.

    Science.gov (United States)

    Bolmatov, Dima; Zhernenkov, Mikhail; Zav'yalov, Dmitry; Stoupin, Stanislav; Cunsolo, Alessandro; Cai, Yong Q

    2016-01-01

    In this paper we present inelastic X-ray scattering experiments in a diamond anvil cell and molecular dynamic simulations to investigate the behavior of phononic excitations in liquid Ar. The spectra calculated using molecular dynamics were found to be in a good agreement with the experimental data. Furthermore, we observe that, upon temperature increases, a low-frequency transverse phononic gap emerges while high-frequency propagating modes become evanescent at the THz scale. The effect of strong localization of a longitudinal phononic mode in the supercritical phase is observed for the first time. The evidence for the high-frequency transverse phononic gap due to the transition from an oscillatory to a ballistic dynamic regimes of motion is presented and supported by molecular dynamics simulations. This transition takes place across the Frenkel line thermodynamic limit which demarcates compressed liquid and non-compressed fluid domains on the phase diagram and is supported by calculations within the Green-Kubo phenomenological formalism. These results are crucial to advance the development of novel terahertz thermal devices, phononic lenses, mirrors, and other THz metamaterials. PMID:26763899

  17. Chip-scale fluorescence microscope based on a silo-filter complementary metal-oxide semiconductor image sensor.

    Science.gov (United States)

    Ah Lee, Seung; Ou, Xiaoze; Lee, J Eugene; Yang, Changhuei

    2013-06-01

    We demonstrate a silo-filter (SF) complementary metal-oxide semiconductor (CMOS) image sensor for a chip-scale fluorescence microscope. The extruded pixel design with metal walls between neighboring pixels guides fluorescence emission through the thick absorptive filter to the photodiode of a pixel. Our prototype device achieves 13 μm resolution over a wide field of view (4.8 mm × 4.4 mm). We demonstrate bright-field and fluorescence longitudinal imaging of living cells in a compact, low-cost configuration. PMID:23722754

  18. Atom Chips

    CERN Document Server

    Folman, R; Cassettari, D; Hessmo, B; Maier, T; Schmiedmayer, J; Folman, Ron; Krüger, Peter; Cassettari, Donatella; Hessmo, Björn; Maier, Thomas

    1999-01-01

    Atoms can be trapped and guided using nano-fabricated wires on surfaces, achieving the scales required by quantum information proposals. These Atom Chips form the basis for robust and widespread applications of cold atoms ranging from atom optics to fundamental questions in mesoscopic physics, and possibly quantum information systems.

  19. Design optimization of liquid-phase flow patterns for microfabricated lung on a chip.

    Science.gov (United States)

    Long, C; Finch, C; Esch, M; Anderson, W; Shuler, M; Hickman, J

    2012-06-01

    Microreactors experience significant deviations from plug flow due to the no-slip boundary condition at the walls of the chamber. The development of stagnation zones leads to widening of the residence time distribution at the outlet of the reactor. A hybrid design optimization process that combines modeling and experiments has been utilized to minimize the width of the residence time distribution in a microreactor. The process was used to optimize the design of a microfluidic system for an in vitro model of the lung alveolus. Circular chambers to accommodate commercial membrane supported cell constructs are a particularly challenging geometry in which to achieve a uniform residence time distribution. Iterative computational fluid dynamics (CFD) simulations were performed to optimize the microfluidic structures for two different types of chambers. The residence time distributions of the optimized chambers were significantly narrower than those of non-optimized chambers, indicating that the final chambers better approximate plug flow. Qualitative and quantitative visualization experiments with dye indicators demonstrated that the CFD results accurately predicted the residence time distributions within the bioreactors. The results demonstrate that such a hybrid optimization process can be used to design microreactors that approximate plug flow for in vitro tissue engineered systems. This technique has broad application for optimization of microfluidic body-on-a-chip systems for drug and toxin studies. PMID:22271245

  20. A broadband chip-scale optical frequency synthesizer at 2.7 × 10−16 relative uncertainty

    Science.gov (United States)

    Huang, Shu-Wei; Yang, Jinghui; Yu, Mingbin; McGuyer, Bart H.; Kwong, Dim-Lee; Zelevinsky, Tanya; Wong, Chee Wei

    2016-01-01

    Optical frequency combs—coherent light sources that connect optical frequencies with microwave oscillations—have become the enabling tool for precision spectroscopy, optical clockwork, and attosecond physics over the past decades. Current benchmark systems are self-referenced femtosecond mode-locked lasers, but Kerr nonlinear dynamics in high-Q solid-state microresonators has recently demonstrated promising features as alternative platforms. The advance not only fosters studies of chip-scale frequency metrology but also extends the realm of optical frequency combs. We report the full stabilization of chip-scale optical frequency combs. The microcomb’s two degrees of freedom, one of the comb lines and the native 18-GHz comb spacing, are simultaneously phase-locked to known optical and microwave references. Active comb spacing stabilization improves long-term stability by six orders of magnitude, reaching a record instrument-limited residual instability of 3.6mHz/τ. Comparing 46 nitride frequency comb lines with a fiber laser frequency comb, we demonstrate the unprecedented microcomb tooth-to-tooth relative frequency uncertainty down to 50 mHz and 2.7 × 10−16, heralding novel solid-state applications in precision spectroscopy, coherent communications, and astronomical spectrography. PMID:27152341

  1. A broadband chip-scale optical frequency synthesizer at 2.7 × 10(-16) relative uncertainty.

    Science.gov (United States)

    Huang, Shu-Wei; Yang, Jinghui; Yu, Mingbin; McGuyer, Bart H; Kwong, Dim-Lee; Zelevinsky, Tanya; Wong, Chee Wei

    2016-04-01

    Optical frequency combs-coherent light sources that connect optical frequencies with microwave oscillations-have become the enabling tool for precision spectroscopy, optical clockwork, and attosecond physics over the past decades. Current benchmark systems are self-referenced femtosecond mode-locked lasers, but Kerr nonlinear dynamics in high-Q solid-state microresonators has recently demonstrated promising features as alternative platforms. The advance not only fosters studies of chip-scale frequency metrology but also extends the realm of optical frequency combs. We report the full stabilization of chip-scale optical frequency combs. The microcomb's two degrees of freedom, one of the comb lines and the native 18-GHz comb spacing, are simultaneously phase-locked to known optical and microwave references. Active comb spacing stabilization improves long-term stability by six orders of magnitude, reaching a record instrument-limited residual instability of [Formula: see text]. Comparing 46 nitride frequency comb lines with a fiber laser frequency comb, we demonstrate the unprecedented microcomb tooth-to-tooth relative frequency uncertainty down to 50 mHz and 2.7 × 10(-16), heralding novel solid-state applications in precision spectroscopy, coherent communications, and astronomical spectrography. PMID:27152341

  2. Submission of the First Full Scale Prototype Chip for Upgraded ATLAS Pixel Detector at LHC, FE-I4A

    CERN Document Server

    Barbero, M; The ATLAS collaboration; Beccherle, R; Darbo, G; Dube, S; Elledge, D; Fleury, J; Fougeron, D; Garcia-Sciveres, M; Gensolen, F; Gnani, D; Gromov, V; Jensen, F; Hemperek, T; Karagounis, M; Kluit, R; Kruth, A; Mekkaoui, A; Menouni, M; Schipper, JD; Wermes, N; Zivkovic, V

    2010-01-01

    A new ATLAS pixel chip FE-I4 is being developed for use in upgraded LHC luminosity environments, including the near-term Insertable B-Layer (IBL) upgrade. FE-I4 is designed in a 130nm CMOS technology, presenting advantages in terms of radiation tolerance and digital logic density compared to the 250nm CMOS technology used for the current ATLAS pixel IC, FE-I3. The FE-I4 architecture is based on an array of 80x336 pixels, each 50x250um^2, consisting of analog and digital sections. In the summer 2010, a first full scale prototype FE-I4A was submitted for an engineering run. This IC features the full scale pixel array as well as the complex periphery of the future full-size FE-I4. The FE-I4A contains also various extra test features which should prove very useful for the chip characterization, but deviate from the needs for standard operation of the final FE-I4 for IBL. In this paper, focus will be brought to the various features implemented in the FE-I4A submission, while also underlining the main differences b...

  3. Long-scale evolution of thin liquid films

    International Nuclear Information System (INIS)

    Macroscopic thin liquid films are entities that are important in biophysics, physics, and engineering, as well as in natural settings. They can be composed of common liquids such as water or oil, rheologically complex materials such as polymers solutions or melts, or complex mixtures of phases or components. When the films are subjected to the action of various mechanical, thermal, or structural factors, they display interesting dynamic phenomena such as wave propagation, wave steepening, and development of chaotic responses. Such films can display rupture phenomena creating holes, spreading of fronts, and the development of fingers. In this review a unified mathematical theory is presented that takes advantage of the disparity of the length scales and is based on the asymptotic procedure of reduction of the full set of governing equations and boundary conditions to a simplified, highly nonlinear, evolution equation or to a set of equations. As a result of this long-wave theory, a mathematical system is obtained that does not have the mathematical complexity of the original free-boundary problem but does preserve many of the important features of its physics. The basics of the long-wave theory are explained. If, in addition, the Reynolds number of the flow is not too large, the analogy with Reynolds close-quote s theory of lubrication can be drawn. A general nonlinear evolution equation or equations are then derived and various particular cases are considered. Each case contains a discussion of the linear stability properties of the base-state solutions and of the nonlinear spatiotemporal evolution of the interface (and other scalar variables, such as temperature or solute concentration). The cases reducing to a single highly nonlinear evolution equation are first examined. (Abstract Truncated)

  4. Large-scale analysis of antisense transcription in wheat using the Affymetrix GeneChip Wheat Genome Array

    Directory of Open Access Journals (Sweden)

    Settles Matthew L

    2009-05-01

    Full Text Available Abstract Background Natural antisense transcripts (NATs are transcripts of the opposite DNA strand to the sense-strand either at the same locus (cis-encoded or a different locus (trans-encoded. They can affect gene expression at multiple stages including transcription, RNA processing and transport, and translation. NATs give rise to sense-antisense transcript pairs and the number of these identified has escalated greatly with the availability of DNA sequencing resources and public databases. Traditionally, NATs were identified by the alignment of full-length cDNAs or expressed sequence tags to genome sequences, but an alternative method for large-scale detection of sense-antisense transcript pairs involves the use of microarrays. In this study we developed a novel protocol to assay sense- and antisense-strand transcription on the 55 K Affymetrix GeneChip Wheat Genome Array, which is a 3' in vitro transcription (3'IVT expression array. We selected five different tissue types for assay to enable maximum discovery, and used the 'Chinese Spring' wheat genotype because most of the wheat GeneChip probe sequences were based on its genomic sequence. This study is the first report of using a 3'IVT expression array to discover the expression of natural sense-antisense transcript pairs, and may be considered as proof-of-concept. Results By using alternative target preparation schemes, both the sense- and antisense-strand derived transcripts were labeled and hybridized to the Wheat GeneChip. Quality assurance verified that successful hybridization did occur in the antisense-strand assay. A stringent threshold for positive hybridization was applied, which resulted in the identification of 110 sense-antisense transcript pairs, as well as 80 potentially antisense-specific transcripts. Strand-specific RT-PCR validated the microarray observations, and showed that antisense transcription is likely to be tissue specific. For the annotated sense

  5. Neutrino physics with multi-ton scale liquid xenon detectors

    CERN Document Server

    Baudis, L; Kish, A; Manalaysay, A; Undagoitia, T Marrodan; Schumann, M

    2014-01-01

    We study the sensitivity of large-scale xenon detectors to low-energy solar neutrinos, to coherent neutrino-nucleus scattering and to neutrinoless double beta decay. As a concrete example, we consider the xenon part of the proposed DARWIN (Dark Matter WIMP Search with Noble Liquids) experiment. We perform detailed Monte Carlo simulations of the expected backgrounds, considering realistic energy resolutions and thresholds in the detector. In a low-energy window of 2-30 keV, where the sensitivity to solar pp and 7-Be neutrinos is highest, an integrated pp-neutrino rate of 5900 events can be reached in a fiducial mass of 14 tons of natural xenon, after 5 years of data. The pp-neutrino flux could thus be measured with a statistical uncertainty around 1%, reaching the precision of solar model predictions. These low-energy solar neutrinos will be the limiting background to the dark matter search channel for WIMP-nucleon cross sections below ~2x10^-48 cm^2 and WIMP masses around 50 GeV, for an assumed 99.5% rejectio...

  6. Hydrogen-bond acidity of ionic liquids: an extended scale.

    Science.gov (United States)

    Kurnia, Kiki A; Lima, Filipa; Cláudio, Ana Filipa M; Coutinho, João A P; Freire, Mara G

    2015-07-15

    One of the main drawbacks comprising an appropriate selection of ionic liquids (ILs) for a target application is related to the lack of an extended and well-established polarity scale for these neoteric fluids. Albeit considerable progress has been made on identifying chemical structures and factors that influence the polarity of ILs, there still exists a high inconsistency in the experimental values reported by different authors. Furthermore, due to the extremely large number of possible ILs that can be synthesized, the experimental characterization of their polarity is a major limitation when envisaging the choice of an IL with a desired polarity. Therefore, it is of crucial relevance to develop correlation schemes and a priori predictive methods able to forecast the polarity of new (or not yet synthesized) fluids. In this context, and aiming at broadening the experimental polarity scale available for ILs, the solvatochromic Kamlet-Taft parameters of a broad range of bis(trifluoromethylsulfonyl)imide-([NTf2](-))-based fluids were determined. The impact of the IL cation structure on the hydrogen-bond donating ability of the fluid was comprehensively addressed. Based on the large amount of novel experimental values obtained, we then evaluated COSMO-RS, COnductor-like Screening MOdel for Real Solvents, as an alternative tool to estimate the hydrogen-bond acidity of ILs. A three-parameter model based on the cation-anion interaction energies was found to adequately describe the experimental hydrogen-bond acidity or hydrogen-bond donating ability of ILs. The proposed three-parameter model is also shown to present a predictive capacity and to provide novel molecular-level insights into the chemical structure characteristics that influence the acidity of a given IL. It is shown that although the equimolar cation-anion hydrogen-bonding energies (EHB) play the major role, the electrostatic-misfit interactions (EMF) and van der Waals forces (EvdW) also contribute

  7. Multi-scale entropic depletion phenomena in polymer liquids

    Energy Technology Data Exchange (ETDEWEB)

    Banerjee, Debapriya [Department of Materials Science, University of Illinois, Urbana, Illinois 61801 (United States); Schweizer, Kenneth S., E-mail: kschweiz@illinois.edu [Department of Materials Science, University of Illinois, Urbana, Illinois 61801 (United States); Department of Chemistry, University of Illinois, Urbana, Illinois 61801 (United States); Frederick Seitz Materials Research Laboratory, University of Illinois, Urbana, Illinois 61801 (United States)

    2015-06-07

    We apply numerical polymer integral equation theory to study the entropic depletion problem for hard spheres dissolved in flexible chain polymer melts and concentrated solutions over an exceptionally wide range of polymer radius of gyration to particle diameter ratios (R{sub g}/D), particle-monomer diameter ratios (D/d), and chain lengths (N) including the monomer and oligomer regimes. Calculations are performed based on a calibration of the effective melt packing fraction that reproduces the isobaric dimensionless isothermal compressibility of real polymer liquids. Three regimes of the polymer-mediated interparticle potential of mean force (PMF) are identified and analyzed in depth. (i) The magnitude of the contact attraction that dominates thermodynamic stability scales linearly with D/d and exhibits a monotonic and nonperturbative logarithmic increase with N ultimately saturating in the long chain limit. (ii) A close to contact repulsive barrier emerges that grows linearly with D/d and can attain values far in excess of thermal energy for experimentally relevant particle sizes and chain lengths. This raises the possibility of kinetic stabilization of particles in nanocomposites. The barrier grows initially logarithmically with N, attains a maximum when 2R{sub g} ∼ D/2, and then decreases towards its asymptotic long chain limit as 2R{sub g} ≫ D. (iii) A long range (of order R{sub g}) repulsive, exponentially decaying component of the depletion potential emerges when polymer coils are smaller than, or of order, the nanoparticle diameter. Its amplitude is effectively constant for 2R{sub g} ≤ D. As the polymer becomes larger than the particle, the amplitude of this feature decreases extremely rapidly and becomes negligible. A weak long range and N-dependent component of the monomer-particle pair correlation function is found which is suggested to be the origin of the long range repulsive PMF. Implications of our results for thermodynamics and miscibility are

  8. Multi-scale entropic depletion phenomena in polymer liquids

    Science.gov (United States)

    Banerjee, Debapriya; Schweizer, Kenneth S.

    2015-06-01

    We apply numerical polymer integral equation theory to study the entropic depletion problem for hard spheres dissolved in flexible chain polymer melts and concentrated solutions over an exceptionally wide range of polymer radius of gyration to particle diameter ratios (Rg/D), particle-monomer diameter ratios (D/d), and chain lengths (N) including the monomer and oligomer regimes. Calculations are performed based on a calibration of the effective melt packing fraction that reproduces the isobaric dimensionless isothermal compressibility of real polymer liquids. Three regimes of the polymer-mediated interparticle potential of mean force (PMF) are identified and analyzed in depth. (i) The magnitude of the contact attraction that dominates thermodynamic stability scales linearly with D/d and exhibits a monotonic and nonperturbative logarithmic increase with N ultimately saturating in the long chain limit. (ii) A close to contact repulsive barrier emerges that grows linearly with D/d and can attain values far in excess of thermal energy for experimentally relevant particle sizes and chain lengths. This raises the possibility of kinetic stabilization of particles in nanocomposites. The barrier grows initially logarithmically with N, attains a maximum when 2Rg ˜ D/2, and then decreases towards its asymptotic long chain limit as 2Rg ≫ D. (iii) A long range (of order Rg) repulsive, exponentially decaying component of the depletion potential emerges when polymer coils are smaller than, or of order, the nanoparticle diameter. Its amplitude is effectively constant for 2Rg ≤ D. As the polymer becomes larger than the particle, the amplitude of this feature decreases extremely rapidly and becomes negligible. A weak long range and N-dependent component of the monomer-particle pair correlation function is found which is suggested to be the origin of the long range repulsive PMF. Implications of our results for thermodynamics and miscibility are discussed.

  9. Liquid extraction surface analysis (LESA) of hydrophobic TLC plates coupled to chip-based nanoelectrospray high-resolution mass spectrometry.

    Science.gov (United States)

    Himmelsbach, Markus; Varesio, Emmanuel; Hopfgartner, Gérard

    2014-01-01

    Direct identification and structural characterization of analyte spots on TLC plates have always been of great interest and the development of interfaces that allow TLC to be combined with MS is making steady progress. The recently introduced liquid extraction surface analysis (LESA) approach has the potential to hyphenate TLC with MS. A mixture of lipid standards was separated on HPTLC RP-18 glass plates using chloroform:methanol :acetonitrile 2:1:1 (v:v:v) as mobile phase. After visualization with primuline dye (0.02% in acetone:water 8:2 (v:v)), LESA was performed, followed by a chip-based nanoflow infusion in combination with FTICRMS. The optimized extraction solvent composition was methanol:chloroform:water:formic acid 52:24:24:0.2 (v:v:v:v). A nanoelectrospray voltage of 1.6 kV and a gas pressure of 0.2 psi were applied in all experiments. All phospholipids were extracted successfully and detected unambiguously using the optimized TLC-LESA-FTICRMS procedure. Sampling the tricaprylin spot gave the most intense signals and also tricaprin was detected. Three other triacylglycerols of higher molecular mass have logP values between 15.5 and 21.6, which are the highest among all investigated compounds and are not detected from their corresponding spots, due to the fact that the solubility of very apolar lipids is not high enough in the extraction solvent. It was demonstrated that TLC can be elegantly combined with mass spectrometry based on the LESA approach. In general, apart from the analysis of lipids, TLC-LESA-MS has a high potential for medium-polar compounds separated on reversed-phase TLC plates, but limitations are present when very apolar compounds have to be extracted. PMID:24801846

  10. Three-Dimensional Architecture at Chip Level for Large-Scale-Integration of Superconducting Quantum Electronic Devices

    Science.gov (United States)

    Göppl, Martin; Kurpiers, Philipp; Wallraff, Andreas

    We propose a novel way to realize three-dimensional circuit QED systems at chip level. System components such as qubits, transmission lines, capacitors, inductors or cross-overs can be implemented as suspended, electromagnetically shielded and optionally, as hermetically sealed structures. Compared to known state-of-the-art devices, volumes of dielectrics penetrated by electromagnetic fields can be drastically reduced. Our intention is to harness process technologies for very-large-scale-integration, reliably applied and improved over decades in micro-sensor- and semiconductor industry, for the realization of highly integrated circuit QED systems. Process capabilities are demonstrated by fabricating first exploratory devices using the back-end-of-line part of a commercial 180 nm CMOS foundry process in conjunction with HF vapor phase release etching.

  11. Nanometer-scale dynamics of high-temperature levitated liquids

    Directory of Open Access Journals (Sweden)

    D.L.Price

    2008-03-01

    Full Text Available We review recent measurements of the microscopic dynamics of high-temperature liquids made with inelastic x-ray scattering and aerodynamic levitation of the samples. Phenomenological and theoretical interpretations are also discussed.

  12. Excess Entropy Scaling Law for Diffusivity in Liquid Metals

    Science.gov (United States)

    Jakse, N.; Pasturel, A.

    2016-01-01

    Understanding how dynamic properties depend on the structure and thermodynamics in liquids is a long-standing open problem in condensed matter physics. A very simple approach is based on the Dzugutov contribution developed on model fluids in which a universal (i.e. species-independent) connection relates the pair excess entropy of a liquid to its reduced diffusion coefficient. However its application to “real” liquids still remains uncertain due to the ability of a hard sphere (HS) reference fluid used in reducing parameters to describe complex interactions that occur in these liquids. Here we use ab initio molecular dynamics simulations to calculate both structural and dynamic properties at different temperatures for a wide series of liquid metals including Al, Au, Cu, Li, Ni, Ta, Ti, Zn as well as liquid Si and B. From this analysis, we demonstrate that the Dzugutov scheme can be applied successfully if a self-consistent method to determine the packing fraction of the hard sphere reference fluid is used as well as the Carnahan-Starling approach to express the excess entropy. PMID:26862002

  13. Excess Entropy Scaling Law for Diffusivity in Liquid Metals.

    Science.gov (United States)

    Jakse, N; Pasturel, A

    2016-01-01

    Understanding how dynamic properties depend on the structure and thermodynamics in liquids is a long-standing open problem in condensed matter physics. A very simple approach is based on the Dzugutov contribution developed on model fluids in which a universal (i.e. species-independent) connection relates the pair excess entropy of a liquid to its reduced diffusion coefficient. However its application to "real" liquids still remains uncertain due to the ability of a hard sphere (HS) reference fluid used in reducing parameters to describe complex interactions that occur in these liquids. Here we use ab initio molecular dynamics simulations to calculate both structural and dynamic properties at different temperatures for a wide series of liquid metals including Al, Au, Cu, Li, Ni, Ta, Ti, Zn as well as liquid Si and B. From this analysis, we demonstrate that the Dzugutov scheme can be applied successfully if a self-consistent method to determine the packing fraction of the hard sphere reference fluid is used as well as the Carnahan-Starling approach to express the excess entropy. PMID:26862002

  14. Slip, Crystal Orientation, and Damage Evolution During Thermal Cycling in High-Strain Wafer-Level Chip-Scale Packages

    Science.gov (United States)

    Zhou, Bite; Zhou, Quan; Bieler, Thomas R.; Lee, Tae-kyu

    2015-03-01

    Wafer-level chip-scale package samples with pre-cross-sectioned edge rows were thermally cycled to study microstructure evolution and damage development. Electron backscattered diffraction (EBSD) and high-energy x-ray diffraction were used to obtain Sn grain orientations and the average coefficient of thermal expansion normal to the board in every joint of the package for samples in the as-fabricated and thermally cycled conditions. The results indicated a near-random distribution of joint orientation. Optical, scanning electron microscopy, and EBSD methods were used to characterize microstructure changes in pre-cross-sectioned samples due to thermal cycling. Slip trace analysis and Orientation Imaging Microscopy™ (OIM) show that slip systems with high Schmid factors (estimated global shear stress based on the package neutral point) are responsible for the observed microstructure evolution during thermal cycling, which provides information about slip systems that are more easily activated. Two joints were analyzed in detail to evaluate slip activity at different stages of their thermal history. The first case showed that a solidification twin grain boundary misorientation deviated from the twin relationship due to slip activity during thermal cycling, which can influence damage development and the path of crack propagation. The second case showed a new grain orientation developing due to gradual lattice rotation about the Sn [110] axis by a continuous recrystallization mechanism. This rotation was correlated with the operation of slip system . Small tin whiskers emerged from the initially polished chip interface and grew with increasing thermal cycles until a crack developed in the solder that relieved the stress. As the local stresses are not known experimentally, this analysis provides observations that can be compared with a crystal plasticity model simulation.

  15. On the electric breakdown in liquid argon at centimeter scale

    Science.gov (United States)

    Auger, M.; Blatter, A.; Ereditato, A.; Goeldi, D.; Janos, S.; Kreslo, I.; Luethi, M.; von Rohr, C. Rudolf; Strauss, T.; Weber, M. S.

    2016-03-01

    We present a study on the dependence of electric breakdown discharge properties on electrode geometry and the breakdown field in liquid argon near its boiling point. The measurements were performed with a spherical cathode and a planar anode at distances ranging from 0.1 mm to 10.0 mm. A detailed study of the time evolution of the breakdown volt-ampere characteristics was performed for the first time. It revealed a slow streamer development phase in the discharge. The results of a spectroscopic study of the visible light emission of the breakdowns complement the measurements. The light emission from the initial phase of the discharge is attributed to electro-luminescence of liquid argon following a current of drifting electrons. These results contribute to set benchmarks for breakdown-safe design of ionization detectors, such as Liquid Argon Time Projection Chambers (LAr TPC).

  16. On the Electric Breakdown in Liquid Argon at Centimeter Scale

    CERN Document Server

    Auger, M; Ereditato, A; Goeldi, D; Janos, S; Kreslo, I; Luethi, M; von Rohr, C Rudolf; Strauss, T; Weber, M S

    2015-01-01

    We present a study on the dependence of electric breakdown discharge parameters on electrode geometry and the breakdown field in liquid argon near its boiling point. The measurements were performed with a spherical cathode and a planar anode at distances ranging from 0.1 mm to 10.0 mm. A detailed study of the time evolution of the breakdown volt-ampere characteristics was performed for the first time. It revealed a slow streamer development phase in the discharge. The results of a spectroscopic study of the visible light emission of the breakdowns complement the measurements. The light emission from the initial phase of the discharge is attributed to electro-luminescence of liquid argon following a current of drifting electrons. These results contribute to set benchmarks for breakdown-safe design of ionization detectors, such as Liquid Argon Time Projection Chambers (LAr TPC).

  17. On-chip frame memory reduction using a high-compression-ratio codec in the overdrives of liquid-crystal displays

    Science.gov (United States)

    Wang, Jun; Min, Kyeong-Yuk; Chong, Jong-Wha

    2010-11-01

    Overdrive is commonly used to reduce the liquid-crystal response time and motion blur in liquid-crystal displays (LCDs). However, overdrive requires a large frame memory in order to store the previous frame for reference. In this paper, a high-compression-ratio codec is presented to compress the image data stored in the on-chip frame memory so that only 1 Mbit of on-chip memory is required in the LCD overdrives of mobile devices. The proposed algorithm further compresses the color bitmaps and representative values (RVs) resulting from the block truncation coding (BTC). The color bitmaps are represented by a luminance bitmap, which is further reduced and reconstructed using median filter interpolation in the decoder, while the RVs are compressed using adaptive quantization coding (AQC). Interpolation and AQC can provide three-level compression, which leads to 16 combinations. Using a rate-distortion analysis, we select the three optimal schemes to compress the image data for video graphics array (VGA), wide-VGA LCD, and standard-definitionTV applications. Our simulation results demonstrate that the proposed schemes outperform interpolation BTC both in PSNR (by 1.479 to 2.205 dB) and in subjective visual quality.

  18. Hidden scale invariance in molecular van der Waals liquids: A simulation study

    Science.gov (United States)

    Schrøder, Thomas B.; Pedersen, Ulf R.; Bailey, Nicholas P.; Toxvaerd, Søren; Dyre, Jeppe C.

    2009-10-01

    Results from molecular dynamics simulations of two viscous molecular model liquids—the Lewis-Wahnström model of orthoterphenyl and an asymmetric dumbbell model—are reported. We demonstrate that the liquids have a “hidden” approximate scale invariance: equilibrium potential energy fluctuations are accurately described by inverse power-law (IPL) potentials, the radial distribution functions are accurately reproduced by the IPL’s, and the radial distribution functions obey the IPL predicted scaling properties to a good approximation. IPL scaling of the dynamics also applies—with the scaling exponent predicted by the equilibrium fluctuations. In contrast, the equation of state does not obey the IPL scaling. We argue that our results are general for van der Waals liquids, but do not apply, e.g., for hydrogen-bonded liquids.

  19. Novel on chip-interconnection structures for giga-scale integration VLSI ICS

    Science.gov (United States)

    Nelakuditi, Usha R.; Reddy, S. N.

    2013-01-01

    Based on the guidelines of International Technology Roadmap for Semiconductors (ITRS) Intel has already designed and manufactured the next generation product of the Itanium family containing 1.72 billion transistors. In each new technology due to scaling, individual transistors are becoming smaller and faster, and are dissipating low power. The main challenge with these systems is wiring of these billion transistors since wire length interconnect scaling increases the distributed resistance-capacitance product. In addition, high clock frequencies necessitate reverse scaling of global and semi-global interconnects so that they satisfy the timing constraints. Hence, the performances of future GSI systems will be severely restricted by interconnect performance. It is therefore essential to look at interconnect design techniques that will reduce the impact of interconnect networks on the power, performance and cost of the entire system. In this paper a new routing technique called Wave-Pipelined Multiplexed (WPM) Routing similar to Time Division Multiple Access (TDMA) is discussed. This technique is highly useful for the current high density CMOS VLSI ICs. The major advantages of WPM routing technique are flexible, robust, simple to implement, and realized with low area, low power and performance overhead requirements.

  20. Development of a microfluidic-chip system for liquid-phase microextraction based on two immiscible organic solvents for the extraction and preconcentration of some hormonal drugs.

    Science.gov (United States)

    Asl, Yousef Abdossalami; Yamini, Yadollah; Seidi, Shahram

    2016-11-01

    In the present study, for the first time, an on-chip liquid phase microextraction (LPME) coupled with high performance liquid chromatography was introduced for the analysis of levonorgestrel (Levo), dydrogesterone (Dydo) and medroxyprogesterone (Medo) as the model analytes in biological samples. The chip-based LPME set-up was composed of two polymethyl methacrylate (PMMA) plates with microfabricated channels and a microporous membrane sandwiched between them to separate the sample solution and acceptor phase. These channels were used as a flow path for the sample solution and a thin compartment for the acceptor phase, respectively. In this system, two immiscible organic solvents were used as supported liquid membrane (SLM) and acceptor phase, respectively. During extraction, the model analytes in the sample solution were transported through the SLM (n-dodecane) into the acceptor organic solvent (methanol). The new set-up provided effective and reproducible extractions using low volumes of the sample solution. The effective parameters on the extraction efficiency of the model analytes were optimized using one variable at a time method. Under the optimized conditions, the new set-up provided good linearity in the range of 5.0-500µgL(-1) for the model analytes with the coefficients of determination (r(2)) higher than 0.9909. The relative standard deviations (RSDs%) and limits of detection (LODs) values were less than 6.5% (n=5) and 5.0µgL(-1), respectively. The preconcentration factors (PFs) were obtained using 1.0mL of the sample solution and 20.0µL of the acceptor solution higher than 19.9-fold. Finally, the proposed method was successfully applied for the extraction and determination of the model analytes in urine samples. PMID:27591655

  1. Real-Time Very Large-Scale Integration Recognition System with an On-Chip Adaptive K-Means Learning Algorithm

    Science.gov (United States)

    Hou, Zuoxun; Ma, Yitao; Zhu, Hongbo; Zheng, Nanning; Shibata, Tadashi

    2013-04-01

    A very large-scale integration (VLSI) recognition system equipped with an on-chip learning capability has been developed for real-time processing applications. This system can work in two functional modes of operation: adaptive K-means learning mode and recognition mode. In the adaptive K-means learning mode, the variance ratio criterion (VRC) has been employed to evaluate the quality of K-means classification results, and the evaluation algorithm has been implemented on the chip. As a result, it has become possible for the system to autonomously determine the optimum number of clusters (K). In the recognition mode, the nearest-neighbor search algorithm is very efficiently carried out by the fully parallel architecture employed in the chip. In both modes of operation, many hardware resources are shared and the functionality is flexibly altered by the system controller designed as a finite-state machine (FSM). The chip is implemented on Altera Cyclone II FPGA with 46K logic cells. Its operating clock is 25 MHz and the processing times for adaptive learning and recognition with 256 64-dimension feature vectors are about 0.42 ms and 4 µs, respectively. Both adaptive K-means learning and recognition functions have been verified by experiments using the image data from the COIL-100 (Columbia University Object Image Library) database.

  2. Self-adaptive phosphor coating technology for wafer-level scale chip packaging

    Institute of Scientific and Technical Information of China (English)

    Zhou Linsong; Rao Haibo; Wang Wei; Wan Xianlong; Liao Junyuan; Wang Xuemei; Zhou Da

    2013-01-01

    A new self-adaptive phosphor coating technology has been successfully developed,which adopted a slurry method combined with a self-exposure process.A phosphor suspension in the water-soluble photoresist was applied and exposed to LED blue light itself and developed to form a conformal phosphor coating with selfadaptability to the angular distribution of intensity of blue light and better-performing spatial color uniformity.The self-adaptive phosphor coating technology had been successfully adopted in the wafer surface to realize a waferlevel scale phosphor conformal coating.The first-stage experiments show satisfying results and give an adequate demonstration of the flexibility of self-adaptive coating technology on application of WLSCP.

  3. SU-8 cantilever chip interconnection

    DEFF Research Database (Denmark)

    Johansson, Alicia Charlotte; Janting, Jakob; Schultz, Peter;

    2006-01-01

    the electrodes on the SU-8 chip to a printed circuit board. Here, we present two different methods of electrically connecting an SU-8 chip, which contains a microfluidic network and free-hanging mechanical parts. The tested electrical interconnection techniques are flip chip bonding using underfill or flip chip...... bonding using an anisotropic conductive film (ACF). These are both widely used in the Si industry and might also be used for the large scale interconnection of SU-8 chips. The SU-8 chip, to which the interconnections are made, has a microfluidic channel with integrated micrometer-sized cantilevers...... that can be used for label-free biochemical detection. All the bonding tests are compared with results obtained using similar Si chips. It is found that it is significantly more complicated to interconnect SU-8 than Si cantilever chips primarily due to the softness of SU-8....

  4. Small- and Large-scale Characterization and Mixing Properties in a Thermally Driven Thin Liquid Film

    CERN Document Server

    Winkler, Michael

    2015-01-01

    Thin liquid films are nanoscopic elements of foams, emulsions and suspensions, and form a paradigm for nanochannel transport that eventually test the limits of hydrodynamic descriptions. Here we use classical dynamical systems characteristics to study the complex interplay of thermal convection, interface and gravitational forces which yields turbulent mixing and transport: Lyapunov exponents and entropies. We induce a stable two eddy convection in an extremely thin liquid film by applying a temperature gradient. Experimentally, we determine the small-scale dynamics using the motion and deformation of spots of equal size/equal color, we dubbed that technique "color imaging velocimetry". The large-scale dynamics is captured by encoding the left/right motion of the liquid directed to the left or right of the separatrix between the two rolls. This way, we characterize chaos of course mixing in this peculiar fluid geometry of a thin, free-standing liquid film.

  5. The combination of liquid chromatography/tandem mass spectrometry and chip-based infusion for improved screening and characterization of drug metabolites.

    Science.gov (United States)

    Staack, Roland F; Varesio, Emmanuel; Hopfgartner, Gérard

    2005-01-01

    An approach has been developed for drug metabolism studies of non-radiolabeled compounds using on-line liquid chromatography/tandem mass spectrometry (LC/MS/MS) combined with chip-based infusion following fraction collection. The potential of this approach, which improves the data quality compared with only LC/MS analysis, has been investigated for the analysis of in vitro metabolites of tolcapone and talinolol, two compounds with well-characterized metabolism. The information-dependent LC/MS/MS analysis enables the characterization of the major metabolites while the chip-based infusion is used to obtain good product ion spectra for lower level metabolites, to generate complementary MS information on potential metabolites detected in the LC/MS trace, or to screen for unexpected metabolites. Fractions from the chromatographic analysis are collected in 20 second steps, into a 96-well plate. The fractions of interest can be re-analyzed with chip-based infusion on a variety of mass spectrometers including triple quadrupole linear ion trap (QqLIT or Q TRAP) and QqTOF systems. Acquiring data for several minutes using multi-channel acquisition (MCA), or signal averaging while infusing the fractions at approximately 200 nL/min, permits about a 50 times gain in sensitivity (signal-to-noise) in MS/MS mode. A 5-10 microL sample fraction can be infused for more than 30 min allowing the time to perform various MS experiments such as MS(n), precursor ion or neutral loss scans and accurate mass measurement, all in either positive or negative mode. Through fraction collection and infusion, a significant gain in data quality is obtained along with a time-saving benefit, because the original sample needs neither to be re-analyzed by re-injection nor to be pre-concentrated. Therefore, a novel hydroxylated talinolol metabolite could be characterized with only one injection. PMID:15685686

  6. Radioistopes to Solar to High Energy Accelerators – Chip-Scale Energy Sources

    International Nuclear Information System (INIS)

    This talk will present MEMS based power sources that utilize radioisotopes, solar energy, and potentially nuclear energy through advancements in integration of new structures and materials within MEMS. Micro power harvesters can harness power from vibration, radioisotopes, light, sound, and biology may provide pathways to minimize or even eliminate batteries in sensor nodes. In this talk work on radioisotope thin films for MEMS will be include the self-reciprocating cantilever, betavoltaic cells, and high DC voltages. The self-reciprocating cantilever energy harvester allows small commercially viable amounts of radioisotopes to generate mW to Watts of power so that very reliable power sources that last 100s of years are possible. The tradeoffs between reliability and potential stigma with radioisotopes allow one to span a useful design space with reliability as a key parameter. These power sources provide pulsed power at three different time scales using mechanical, RF, and static extraction of energy from collected charge. Multi-use capability, both harvesting radioisotope power and local vibration energy extends the reliability of micro-power sources further

  7. Experimental determination of the nucleation rates of undercooled micron-sized liquid droplets based on fast chip calorimetry

    International Nuclear Information System (INIS)

    Highlights: • Fast scanning calorimeter calibration with position dependence. • Calibration of fast scanning calorimeter during cooling. • Quantitative determination of nucleation rates by treating the undercooling as stochastic parameter - Abstract: Accurate thermal analyzes and calorimetry measurements depend on careful calibration measurements. For conventional differential scanning calorimeters (DSC) the calibration procedure is well known. The melting point of different pure metals is measured and compared with literature data to adjust the temperature reading of the calorimeter. Likewise, the measured melting enthalpies of standard reference substances serve for enthalpy calibration. Yet for fast chip calorimetry, new procedures need to be established. For the medium-area and large-area calorimeter chips, this procedure needs to be modified, because the calibration behavior depends on the position of the sample on the measurement area. Additionally, a way to calibrate the calorimeter for measurements performed during cooling will also be shown. For this second aspect, the athermal and diffusionless martensitic phase transformation of Ni49.9–Ti50.1 at% was used. The well-calibrated sensor chips are ideally suited to perform nucleation rate density analyzes based on a statistical approach. Here, the nucleation rate densities of micron-sized pure Sn droplets that had been coated with a non-catalytic coating have been determined by experimental analysis of the statistical variance of the undercooling response

  8. Boiling liquid expanding vapour explosion in CO2 small scale experiments

    OpenAIRE

    Bjerketvedt, Dag; Egeberg, Kjersti; Ke, Wei; Gaathaug, Andre Vagner; Vågsæther, Knut; Nilsen, S. H.

    2011-01-01

    Carbon capture and storage systems require handling large volumes of high pressure CO2. Having thorough knowledge of the related hazards is essential, as is knowing how to prevent, detect, control and mitigate accidents. This paper gives a short description of CO2 Boiling Liquid Expanding Vapour Explosions (BLEVEs) and presents results from preliminary, small scale experiments with CO2 BLEVEs. The mechanism of superheated liquid CO2 boiling is not fully understood. Analogies can be made betwe...

  9. Diffusion Time-Scale Invariance, Markovization Processes and Memory Effects in Lennard-Jones Liquids

    OpenAIRE

    Yulmetyev, Renat M.; Mokshin, Anatolii V.; Hänggi, Peter

    2004-01-01

    We report the results of calculation of diffusion coefficients for Lennard-Jones liquids, based on the idea of time-scale invariance of relaxation processes in liquids. The results were compared with the molecular dynamics data for Lennard-Jones system and a good agreement of our theory with these data over a wide range of densities and temperatures was obtained. By calculations of the non-Markovity parameter we have estimated numerically statistical memory effects of diffusion in detail.

  10. Scaling of liquid-drop impact craters in wet granular media

    OpenAIRE

    Zhang, Qianyun; Gao, Ming; Zhao, Runchen; Cheng, Xiang

    2015-01-01

    Combining high-speed photography with laser profilometry, we study the dynamics and the morphology of liquid-drop impact cratering in wet granular media---a ubiquitous phenomenon relevant to many important geological, agricultural, and industrial processes. By systematically investigating important variables such as impact energy, the size of impinging drops and the degree of liquid saturation in granular beds, we uncover a novel scaling for the size of impact craters. We show that this scali...

  11. Benefits and Limitations of Lab-on-a-Chip Method over Reversed-Phase High-Performance Liquid Chromatography Method in Gluten Proteins Evaluation

    Directory of Open Access Journals (Sweden)

    Dragan Živančev

    2015-01-01

    Full Text Available RP-HPLC (reversed-phase high-performance liquid chromatography is widely used to determine the amounts of the different gluten protein types. However, this method is time-consuming, especially at early stages of wheat breeding, when large number of samples needs to be analyzed. On the other hand, LoaC (Lab-on-a-Chip technique has the potential for a fast, reliable, and automatable analysis of proteins. In the present study, benefits and limitations of Lab-on-a-Chip method over RP-HPLC method in gluten proteins evaluation were explored in order to determine in which way LoaC method should be improved in order to make its results more compliant with the results of RP-HPLC method. Strong correlation (P≤0.001 was found between numbers of HMW glutenin peaks determined by LoaC and RP-HPLC methods. Significant correlations (P≤0.05 were obtained between percentages of HMW and LMW glutenin subunits calculated with regard to total HMW + LMW area. Even more significant correlation (P≤0.001 was found when percentages of individual HMW areas were calculated with regard to total HMW. RP-HPLC method showed superiority in determination of gliadins since larger number and better resolution of gliadin peaks were obtained by this method.

  12. Molecular-scale remnants of the liquid-gas transition in supercritical polar fluids.

    Science.gov (United States)

    Sokhan, V P; Jones, A; Cipcigan, F S; Crain, J; Martyna, G J

    2015-09-11

    An electronically coarse-grained model for water reveals a persistent vestige of the liquid-gas transition deep into the supercritical region. A crossover in the density dependence of the molecular dipole arises from the onset of nonpercolating hydrogen bonds. The crossover points coincide with the Widom line in the scaling region but extend farther, tracking the heat capacity maxima, offering evidence for liquidlike and gaslike state points in a "one-phase" fluid. The effect is present even in dipole-limit models, suggesting that it is common for all molecular liquids exhibiting dipole enhancement in the liquid phase. PMID:26406855

  13. Large scale Gd-beta-diketonate based organic liquid scintillator production for antineutrino detection

    CERN Document Server

    Aberle, C; Gramlich, B; Hartmann, F X; Lindner, M; Schönert, S; Schwan, U; Wagner, S; Watanabe, H

    2011-01-01

    Over the course of several decades organic liquid scintillators form the basis for successful neutrino detectors. For electron antineutrino detection at nuclear reactor plants, gadolinium loaded liquid scintillators provide efficient background suppression. In the Double Chooz reactor antineutrino experiment a newly developed gadolinium-loaded scintillator is utilized for the first time. Its large scale production and characterization as well as the creation of an additional metalfree scintillator are presented. Both organic liquids are used in the inner part of the Double Chooz detectors.

  14. MicroSISAK. A new device for fast and continuous liquid-liquid-extractions on a microliter scale

    International Nuclear Information System (INIS)

    The investigation of the chemical properties of the heaviest (transactinide) elements is of great interest in order to assess the significance of relativistic effects on the electron configuration of the transactinide elements. The main problems in studies of the transactinide elements are small production cross sections ranging from the nb'-level down to a few pb and their decay properties, predominantly α-particle emission or spontaneous fission (SF) with half-lives in the order of seconds. Thus, efficient and very fast separation techniques in combination with suitable detection systems have to be applied. In order to overcome these problems, a new device for continuous liquid-liquid-extraction on a microliter scale has been developed in a cooperation between the Chalmers University of Technology in Goeteborg, the Institut fuer Mikrotechnik Mainz (IMM), and the Institut fuer Kernchemie in Mainz. MicroSISAK consists of a stack of micro-structured discs sealed in a Ti-housing. (orig.)

  15. Liquid-liquid phase separation in aerosol particles: Imaging at the Nanometer Scale

    Energy Technology Data Exchange (ETDEWEB)

    O' Brien, Rachel; Wang, Bingbing; Kelly, Stephen T.; Lundt, Nils; You, Yuan; Bertram, Allan K.; Leone, Stephen R.; Laskin, Alexander; Gilles, Mary K.

    2015-04-21

    Atmospheric aerosols can undergo phase transitions including liquid-liquid phase separation (LLPS) while responding to changes in the ambient relative humidity (RH). Here, we report results of chemical imaging experiments using environmental scanning electron microscopy (ESEM) and scanning transmission x-ray microscopy (STXM) to investigate the LLPS of micron sized particles undergoing a full hydration-dehydration cycle. Internally mixed particles composed of ammonium sulfate (AS) and either: limonene secondary organic carbon (LSOC), a, 4-dihydroxy-3-methoxybenzeneaceticacid (HMMA), or polyethylene glycol (PEG-400) were studied. Events of LLPS with apparent core-shell particle morphology were observed for all samples with both techniques. Chemical imaging with STXM showed that both LSOC/AS and HMMA/AS particles were never homogeneously mixed for all measured RH’s above the deliquescence point and that the majority of the organic component was located in the shell. The shell composition was estimated as 65:35 organic: inorganic in LSOC/AS and as 50:50 organic: inorganic for HMMA/AS. PEG-400/AS particles showed fully homogeneous mixtures at high RH and phase separated below 89-92% RH with an estimated 50:50% organic to inorganic mix in the shell. These two chemical imaging techniques are well suited for in-situ analysis of the hygroscopic behavior, phase separation, and surface composition of collected ambient aerosol particles.

  16. Evaluation of liquid-fed ceramic melter scale-up correlations

    International Nuclear Information System (INIS)

    This study was conducted to determine the parameters governing factors of scale for liquid-fed ceramic melters (LFCMs) in order to design full-scale melters using smaller-scale melter data. Results of melter experiments conducted at Pacific Northwest Laboratory (PNL) and Savannah River Laboratory (SRL) are presented for two feed compositions and five different liquid-fed ceramic melters. The melter performance data including nominal feed rate and glass melt rate are correlated as a function of melter surface area. Comparisons are made between the actual melt rate data and melt rates predicted by a cold cap heat transfer model. The heat transfer model could be used in scale-up calculations, but insufficient data are available on the cold cap characteristics. Experiments specifically designed to determine heat transfer parameters are needed to further develop the model. 17 refs

  17. Dynamic scaling near the lambda point of liquid helium and at bicritical points

    International Nuclear Information System (INIS)

    The critical dynamics of liquid helium and of uniaxial antiferromagnets at bicritical points are studied by means of renormalized field theory. The problem of dynamic scaling is analyzed in detail. Explicit calculations are performed using the epsilon-expansion in d = 4 - epsilon dimensions. Results in one- and two-loop order, i.e. first and second order in epsilon, are obtained for dynamic critical exponents, dynamic transient exponents, amplitude ratios and scaling functions at and above the critical points. (orig.)

  18. Flock on a chip

    Science.gov (United States)

    Bartolo, Denis; Desreumaux, Nicolas

    2015-11-01

    We will show how to motorize colloidal particles capable of sensing the orientation of their neighbors and how to handle them in microfluidic chips. These populations of colloidal rollers display non-equilibrium transitions toward swarming or swirling motion depending on the system geometry . After characterizing these emergent patterns we will quantitatively describe them by means of an hydrodynamic theory of polar active liquids.

  19. Liquid drop heat and mass transfer characteristic analysis by using scaling analysis method in containment

    International Nuclear Information System (INIS)

    In the containment analysis of nuclear power plant, containment scaling analysis could be used to confirm the important phenomena of containment cooling system and demonstrate the sufficiency of test data. Based on the design basis accident (DBA) of passive nuclear power plant, the scaling analysis method was used to quantify the effect of heat and mass transfer characteristic of liquid drop to mass, energy and RPC. The effect of containment cooling system phenomena to containment pressure response can be confirmed by this scaling analysis. (authors)

  20. Universal Scaling of Pair-Excess Entropy and Diffusion in Strongly Coupled Liquids

    CERN Document Server

    Joy, Ashwin

    2016-01-01

    Understanding diffusion in liquids from properties of static structure is a long standing problem in condensed matter theory. Here we report an atomistic study of excess entropy and diffusion coefficient in a strongly coupled Yukawa liquid. We observe that the pair excess entropy $s_2$ scales with temperature as $-3.285 \\;(T_m / T)^{0.665}$ and contributes to about $90\\%$ of the total excess entropy close to the freezing transition $T_m$. We further report that at low temperatures where the diffusive transport is mediated by cage relaxation, the diffusion coefficient when expressed in natural units of the Enskog collision frequency and the effective hard sphere diameter, obeys the scaling law $0.04\\; e^{s_2}$ and deviates from it at high enough temperatures where cages cannot form. The scaling laws reported here may also apply to strongly coupled dusty plasmas and charged colloids.

  1. Design and fabrication of a compact chip-scale optical cross-connect enabled by photonic crystals for optical interconnects

    Science.gov (United States)

    Zablocki, Mathew Joseph

    As integrated circuits, such as microprocessors, are fabricated with higher yields and with increasing numbers of smaller and smaller transistors, the communication between discrete elements becomes as important as the elements themselves. The delays associated with signal distribution across the chip have become a limiting factor for processor speeds, and are primarily located within the global interconnect layers for intra-chip and inter-chip communication. Optical interconnects have the potential to relieve the restrictions set by the interconnect bottleneck by taking advantage of their reduced power demands for signal distribution and their lower propagation delays. The work within this dissertation discusses the design, fabrication and characterization of an ultra-compact photonic crystal optical switch for use within a transparent optical cross-connect (OXC). To reduce the size and power consumption of the switch, perturbations were made within the photonic crystal structure to achieve a degree of slow light, decreasing the group velocity of the propagating signals. Further, as a means to integrate the developed switch matrix to a microprocessor in order to serve as a chip's optical global interconnect, a process was developed to transfer the switch fabric to a new substrate as a silicon-nanomembrane (Si-NM). The developed transfer process allows the transfer and stacking of intricate photonic devices, such as the aforementioned switch matrix, to new material platforms and substrates that would be incompatible with typical complementary-metal-oxide-semiconductor CMOS processing. The developed Si-NM processing along with the developed switch matrix for a transparent OXC are significant steps toward implementing an optical interconnect network on a chip.

  2. Length scales in glass-forming liquids and related systems: a review

    Science.gov (United States)

    Karmakar, Smarajit; Dasgupta, Chandan; Sastry, Srikanth

    2016-01-01

    The central problem in the study of glass-forming liquids and other glassy systems is the understanding of the complex structural relaxation and rapid growth of relaxation times seen on approaching the glass transition. A central conceptual question is whether one can identify one or more growing length scale(s) associated with this behavior. Given the diversity of molecular glass-formers and a vast body of experimental, computational and theoretical work addressing glassy behavior, a number of ideas and observations pertaining to growing length scales have been presented over the past few decades, but there is as yet no consensus view on this question. In this review, we will summarize the salient results and the state of our understanding of length scales associated with dynamical slow down. After a review of slow dynamics and the glass transition, pertinent theories of the glass transition will be summarized and a survey of ideas relating to length scales in glassy systems will be presented. A number of studies have focused on the emergence of preferred packing arrangements and discussed their role in glassy dynamics. More recently, a central object of attention has been the study of spatially correlated, heterogeneous dynamics and the associated length scale, studied in computer simulations and theoretical analysis such as inhomogeneous mode coupling theory. A number of static length scales have been proposed and studied recently, such as the mosaic length scale discussed in the random first-order transition theory and the related point-to-set correlation length. We will discuss these, elaborating on key results, along with a critical appraisal of the state of the art. Finally we will discuss length scales in driven soft matter, granular fluids and amorphous solids, and give a brief description of length scales in aging systems. Possible relations of these length scales with those in glass-forming liquids will be discussed.

  3. Finite-size scaling study of shear viscosity anomaly at liquid-liquid criticality

    Science.gov (United States)

    Roy, Sutapa; Das, Subir K.

    2014-12-01

    We study the equilibrium dynamics of a symmetrical binary Lennard-Jones fluid mixture near its consolute criticality. Molecular dynamics simulation results for the shear viscosity, η, from a microcanonical ensemble are compared with those from a canonical ensemble with various thermostats. It is observed that the Nosé-Hoover thermostat is a good candidate for this purpose, and is therefore adopted for the quantification of the critical singularity of η, to avoid the temperature fluctuations (or even drifts) that are often encountered in microcanonical simulations. Via a finite-size scaling analysis of our simulation data we have been able to confirm that the shear viscosity exhibits a weak critical singularity in agreement with the theoretical predictions.

  4. Thermal performance of a meso-scale liquid-fuel combustor

    International Nuclear Information System (INIS)

    Research highlights: → Demonstrated successful combustion of liquid fuel-air mixtures in a novel meso-scale combustor. → Flame quenching was eliminated using heat recirculation in a swiss roll type combustor that also extended the flammability limits. → Liquid fuel was rapidly vaporized with the use of hot narrow channel walls that eliminated the need of a fuel atomizer. → Maximum power density of the combustor was estimated to be about 8.5 GW/m3 and heat load in the range of 50-280W. → Overall efficiency of the combustor was estimated in the range of 12 to 20%. - Abstract: Combustion in small scale devices poses significant challenges due to the quenching of reactions from wall heat losses as well as the significantly reduced time available for mixing and combustion. In the case of liquid fuels there are additional challenges related to atomization, vaporization and mixing with the oxidant in the very short time-scale liquid-fuel combustor. The liquid fuel employed here is methanol with air as the oxidizer. The combustor was designed based on the heat recirculating concept wherein the incoming reactants are preheated by the combustion products through heat exchange occurring via combustor walls. The combustor was fabricated from Zirconium phosphate, a ceramic with very low thermal conductivity (0.8 W m-1 K-1). The combustor had rectangular shaped double spiral geometry with combustion chamber in the center of the spiral formed by inlet and exhaust channels. Methanol and air were introduced immediately upstream at inlet of the combustor. The preheated walls of the inlet channel also act as a pre-vaporizer for liquid fuel which vaporizes the liquid fuel and then mixes with air prior to the fuel-air mixture reaching the combustion chamber. Rapid pre-vaporization of the liquid fuel by the hot narrow channel walls eliminated the necessity for a fuel atomizer. Self-sustained combustion of methanol-air was achieved in a chamber volume as small as 32.6 mm3. The

  5. Estimating the density-scaling exponent of a monatomic liquid from its pair potential

    DEFF Research Database (Denmark)

    Bøhling, Lasse; Bailey, Nicholas; Schrøder, Thomas;

    2014-01-01

    This paper investigates two conjectures for calculating the density dependence of the density-scaling exponent γ of a single-component, pair-potential liquid with strong virial potential-energy correlations. The first conjecture gives an analytical expression for γ directly in terms of the pair...... potential. The second conjecture is a refined version of this involving the most likely nearest-neighbor distance determined from the pair-correlation function. The conjectures are tested by simulations of three systems, one of which is the standard Lennard-Jones liquid. While both expressions give...

  6. Packaging a liquid metal ESD with micro-scale Mercury droplet.

    Energy Technology Data Exchange (ETDEWEB)

    Barnard, Casey Anderson

    2011-08-01

    A liquid metal ESD is being developed to provide electrical switching at different acceleration levels. The metal will act as both proof mass and electric contact. Mercury is chosen to comply with operation parameters. There are many challenges surrounding the deposition and containment of micro scale mercury droplets. Novel methods of micro liquid transfer are developed to deliver controllable amounts of mercury to the appropriate channels in volumes under 1 uL. Issues of hermetic sealing and avoidance of mercury contamination are also addressed.

  7. Non-Fermi-liquid scaling in U(Cu,Al)5 compounds

    International Nuclear Information System (INIS)

    We report on the electronic properties of various UCuxAl5-x compounds (2.9≤x≤3.5). These compounds crystallize in the hexagonal CaCu5 structure. For all compounds, we find that the low-temperature specific heat diverges logarithmitically, which may be taken as an indication of non-Fermi-liquid scaling in these materials. Also we find a large magnetic anisotropy in all compounds studied, and we show that the magnetic anisotropy should not be neglected in the analysis of other bulk properties. Though for some of UCuxAl5-x polycrystals non-Fermi-liquid scaling is found also in the magnetic susceptibility, comparison with single-crystal results on UCu3Al2 indicates that any temperature dependence may be due to averaging anisotropic response over all crystallographic directions

  8. Non-Fermi-liquid scaling in U(Cu,Al)5 compounds

    International Nuclear Information System (INIS)

    We report on the electronic properties of various UCuxAl5-x compounds (2.9 ≤ x ≤ 3.5). These compounds crystallize in the hexagonal CaCu5 structure. For all compounds, we find that the low-temperature specific heat diverges logarithmitically, which may be taken as an indication of non-Fermi-liquid scaling in these materials. Also we find a large magnetic anisotropy in all compounds studied, and we show that the magnetic anisotropy should not be neglected in the analysis of other bulk properties. Though for some of UCuxAl5-x polycrystals non-Fermi-liquid scaling is found also in the magnetic susceptibility, comparison with single-crystal results on UCu3Al2 indicates that any temperature dependence may be due to averaging anisotropic response over all crystallographic directions. (orig.)

  9. Ab initio molecular dynamics simulations with linear scaling: application to liquid ethanol

    International Nuclear Information System (INIS)

    The structural and dynamical properties of liquid ethanol (C2H5OH) at ambient conditions have been studied by ab initio molecular dynamics simulations using a large supercell containing 125 molecules (1125 atoms). The results obtained from a trajectory of 10 ps are found to be in good agreement with available experimental data. Without sacrificing accuracy, the computational cost of simulations is reduced by more than a factor of four by the linear scaling algorithm based on the augmented orbital minimization method

  10. Scale-up and evaluation of high solid ionic liquid pretreatment and enzymatic hydrolysis of switchgrass

    OpenAIRE

    Li, Chenlin; Tanjore, Deepti; He, Wei; Wong, Jessica; Gardner, James L.; Sale, Kenneth L.; Simmons, Blake A.; Singh, Seema

    2013-01-01

    Background Ionic liquid (IL) pretreatment is receiving significant attention as a potential process that enables fractionation of lignocellulosic biomass and produces high yields of fermentable sugars suitable for the production of renewable fuels. However, successful optimization and scale up of IL pretreatment involves challenges, such as high solids loading, biomass handling and transfer, washing of pretreated solids and formation of inhibitors, which are not addressed during the developme...

  11. The application of liquid air energy storage for large scale long duration solutions to grid balancing

    OpenAIRE

    Brett Gareth; Barnett Matthew

    2014-01-01

    Liquid Air Energy Storage (LAES) provides large scale, long duration energy storage at the point of demand in the 5 MW/20 MWh to 100 MW/1,000 MWh range. LAES combines mature components from the industrial gas and electricity industries assembled in a novel process and is one of the few storage technologies that can be delivered at large scale, with no geographical constraints. The system uses no exotic materials or scarce resources and all major components have a proven lifetime of 25+ years....

  12. Fractal Markets Hypothesis and the Global Financial Crisis: Scaling, Investment Horizons and Liquidity

    Czech Academy of Sciences Publication Activity Database

    Krištoufek, Ladislav

    2012-01-01

    Roč. 15, č. 6 (2012), 1250065-1-1250065-13. ISSN 0219-5259 R&D Projects: GA ČR GA402/09/0965 Grant ostatní: GA UK(CZ) 118310; SVV(CZ) 265 504 Institutional support: RVO:67985556 Keywords : fractal markets hypothesis * scaling * fractality * investment horizons * efficient markets hypothesis Subject RIV: AH - Economics Impact factor: 0.647, year: 2012 http://library.utia.cas.cz/separaty/2012/E/kristoufek-fractal markets hypothesis and the global financial crisis scaling investment horizons and liquidity.pdf

  13. Breakup of Thin Liquid Filaments on Partially Wetting Substrates: from Micrometric to Nanometric Scales

    Science.gov (United States)

    Diez, Javier A.; González, Alejandro G.

    2016-04-01

    We present theoretical and experimental results regarding the instability of a thin liquid film in the form a long filament sitted on a solid substrate. We consider this problem in two different scenarios, namely, at submillimetric and nanometric scales, and we study their free surface instability. In the first scale, we take into account the effects due to surface tension and gravity, while in the smaller scale, we add intermolecular interaction and neglect gravity. The flows are modeled within the long wave approximation, which leads to a nonlinear fourth-order differential equation for the fluid thickness. This model equation also includes the partial wetting condition between the liquid and the solid. In the theoretical models, we analyze the linear stability of the equilibrium configurations. The linear stability analyses lead to eigenvalue problems that are solved using pseudo spectral methods in the submillimetric case, and finite differences in the nanoscale. Whenever possible, the theoretical results are compared with experiments performed on a submillimetric scale (silicon oils on glass), as well as on nanometric scale (nickel films melted by laser irradiation on SiO2 substrates).

  14. Preservation of forest wood chips

    Energy Technology Data Exchange (ETDEWEB)

    Kofman, P.D.; Thomsen, I.M.; Ohlsson, C.; Leer, E.; Ravn Schmidt, E.; Soerensen, M.; Knudsen, P.

    1999-01-01

    As part of the Danish Energy Research Programme on biomass utilisation for energy production (EFP), this project concerns problems connected to the handling and storing of wood chips. In this project, the possibility of preserving wood chips of the Norway Spruce (Picea Abies) is addressed, and the potential improvements by anaerobic storage are tested. Preservation of wood chips aims at reducing dry matter losses from extensive heating during storage and to reduce production of fungal spores. Fungal spores pose a health hazards to workers handling the chips. Further the producers of wood chips are interested in such a method since it would enable them to give a guarantee for the delivery of homogeneous wood chips also during the winter period. Three different types of wood chips were stored airtight and further one of these was stored in accordance with normal practise and use as reference. The results showed that airtight storage had a beneficial impact on the quality of the chips: no redistribution of moisture, low dry matter losses, unfavourable conditions for microbial activity of most fungi, and the promotion of yeasts instead of fungi with airborne spores. Likewise the firing tests showed that no combustion problems, and no increased risk to the environment or to the health of staff is caused by anaerobic storage of wood chips. In all, the tests of the anaerobic storage method of forest wood chips were a success and a large-scale test of the method will be carried out in 1999. (au)

  15. Atom chips

    CERN Document Server

    Reichel, Jakob

    2010-01-01

    This book provides a stimulating and multifaceted picture of a rapidly developing field. The first part reviews fundamentals of atom chip research in tutorial style, while subsequent parts focus on the topics of atom-surface interaction, coherence on atom chips, and possible future directions of atom chip research. The articles are written by leading researchers in the field in their characteristic and individual styles.

  16. The Design and Scale-Up of Multiple-Impeller Fermenters for Liquid Film Controlled Processes

    Directory of Open Access Journals (Sweden)

    Labík, L.

    2013-05-01

    Full Text Available Mechanically agitated gas-liquid contactors are frequently used in the chemical, food and biochemical industries as fermenters and as hydrogenation or chlorination reactors. However wide is the usage of such vessels, their design is not based on chemical engineering data, but is still rather empirical. Thus, it is highly desirable to have a tool for the rational design of agitated gas-liquid contactors that is based on fundamental chemical engineering parameters that are transferable to other systems and operating conditions. Focusing on liquid film-controlled processes and using the data from fermenters of different scales, we develop kLa correlations that are suitable for scale-up. First, we discuss how to determine the proper experimental kLa values, which are not distorted by other equipment parameters as is the gas residence time. We demonstrate the possible kLa distortion on the pilot-plant experimental data by comparing the results obtained by two different experimental techniques. Further, we present physically correct kLa data for fully non-coalescent (sodium sulphate solution batch. The data are presented both for laboratory and pilot-plant fermenters. We identify the process parameters, the values of which are dependent on the vessel scale when operated under the same power input per volume, and, using these parameters, we develop common kLa correlations suitable to describe the data for various scales of the vessel. The correlations developed reduce the uncertainty in predicting the volume of industrial scale fermenters from almost 1/2 to 1/4 of their total volume, thereby enabling significant reductions in both the initial costs, and operating costs.

  17. Thermodynamic scaling of molecular dynamics in supercooled liquid state of pharmaceuticals: Itraconazole and ketoconazole

    Science.gov (United States)

    Tarnacka, M.; Madejczyk, O.; Adrjanowicz, K.; Pionteck, J.; Kaminska, E.; Kamiński, K.; Paluch, M.

    2015-06-01

    Pressure-Volume-Temperature (PVT) measurements and broadband dielectric spectroscopy were carried out to investigate molecular dynamics and to test the validity of thermodynamic scaling of two homologous compounds of pharmaceutical activity: itraconazole and ketoconazole in the wide range of thermodynamic conditions. The pressure coefficients of the glass transition temperature (dTg/dp) for itraconazole and ketoconazole were determined to be equal to 183 and 228 K/GPa, respectively. However, for itraconazole, the additional transition to the nematic phase was observed and characterized by the pressure coefficient dTn/dp = 258 K/GPa. From PVT and dielectric data, we obtained that the liquid-nematic phase transition is governed by the relaxation time since it occurred at constant τ α = 10-5 s. Furthermore, we plotted the obtained relaxation times as a function of T-1v-γ, which has revealed that the validity of thermodynamic scaling with the γ exponent equals to 3.69 ± 0.04 and 3.64 ± 0.03 for itraconazole and ketoconazole, respectively. Further analysis of the scaling parameter in itraconazole revealed that it unexpectedly decreases with increasing relaxation time, which resulted in dramatic change of the shape of the thermodynamic scaling master curve. While in the case of ketoconazole, it remained the same within entire range of data (within experimental uncertainty). We suppose that in case of itraconazole, this peculiar behavior is related to the liquid crystals' properties of itraconazole molecule.

  18. Utilization of EDTA as Scale Inhibitor on Evaporation of Liquid Radioactive Waste

    International Nuclear Information System (INIS)

    The evaporation of liquid waste from Serpong Nuclear facilities containing permanent hardness of CaSO4 and MgSO4 on the ratio 1:2 will generate the scale formation constituting the heat resistance of evaporator. On the routine operation, the scale are removed by chemical reaction with immersion of evaporator circuits using nitric acid 10 % during 2.5 days (60 hours) from Friday afternoon to Monday morning or by brushing it on the maintenance period. The preventive action for scale inhibition can be performed by utilization of chemical inhibitor EDTA, the ions of calcium and magnesium reacts with EDTA to form complex compound so the scale formation can be avoided. The quantity of 500 ml simulation of liquid waste containing 2.5 % hardness compound or cation (calcium and magnesium ions) concentration of 6595 ppm was added by 28.30 g EDTA and heat up to boil on the pH variation of 7, 9, 11, and 13 for formation reaction of complex. After the time of initial boiling condition which was varied for 1; 1.5 ; 2 ; 2.5; and 3 hours, the solution was flowed to pass the resin column for free cations catching. That solution be analyzed for determination of calcium and magnesium content complexed by EDTA. The result indicates that on pH 9 gives the maximum of cation complexed by EDTA on the value of 6160 ppm or the percent cation complexed 93.33 %. (author)

  19. Thermodynamic scaling of molecular dynamics in supercooled liquid state of pharmaceuticals: Itraconazole and ketoconazole

    International Nuclear Information System (INIS)

    Pressure-Volume-Temperature (PVT) measurements and broadband dielectric spectroscopy were carried out to investigate molecular dynamics and to test the validity of thermodynamic scaling of two homologous compounds of pharmaceutical activity: itraconazole and ketoconazole in the wide range of thermodynamic conditions. The pressure coefficients of the glass transition temperature (dTg/dp) for itraconazole and ketoconazole were determined to be equal to 183 and 228 K/GPa, respectively. However, for itraconazole, the additional transition to the nematic phase was observed and characterized by the pressure coefficient dTn/dp = 258 K/GPa. From PVT and dielectric data, we obtained that the liquid-nematic phase transition is governed by the relaxation time since it occurred at constant τ α = 10−5 s. Furthermore, we plotted the obtained relaxation times as a function of T−1v−γ, which has revealed that the validity of thermodynamic scaling with the γ exponent equals to 3.69 ± 0.04 and 3.64 ± 0.03 for itraconazole and ketoconazole, respectively. Further analysis of the scaling parameter in itraconazole revealed that it unexpectedly decreases with increasing relaxation time, which resulted in dramatic change of the shape of the thermodynamic scaling master curve. While in the case of ketoconazole, it remained the same within entire range of data (within experimental uncertainty). We suppose that in case of itraconazole, this peculiar behavior is related to the liquid crystals’ properties of itraconazole molecule

  20. Gain chip design, power scaling and intra-cavity frequency doubling with LBO of optically pumped red-emitting AlGaInP-VECSELs

    Science.gov (United States)

    Kahle, Hermann; Mateo, Cherry M. N.; Brauch, Uwe; Bek, Roman; Schwarzbäck, Thomas; Jetter, Michael; Graf, Thomas; Michler, Peter

    2016-03-01

    The wide range of applications in biophotonics, television or projectors, spectroscopy and lithography made the optically-pumped semiconductor (OPS) vertical external cavity surface-emitting lasers (VECSELs) an important category of power scalable lasers. The possibility of bandgap engineering, inserting frequency selective and converting elements into the open laser cavity and laser emission in the fundamental Gaussian mode leads to ongoing growth of the area of applications for tuneable laser sources. We present an AlGaInP-VECSEL system with a multi quantum well structure consisting of compressively strained GaInP quantum wells in an AlxGa1-xInP separate confinement heterostructure with an emission wavelength around 665 nm. The VECSEL chip with its n-λ cavity is pumped by a 532nm Nd:YAG laser under an angle to the normal incidence of 50°. In comparison, a gain chip design for high absorption values at pump wavelengths around 640nm with the use of quantum dot layers as active material is also presented. Frequency doubling is now realized with an antireflection coated lithium borate crystal, while a birefringent filter, placed inside the laser cavity under Brewster's angle, is used for frequency tuning. Further, power-scaling methods like in-well pumping as well as embedding the active region of a VECSEL between two transparent ic heaspreaders are under investigation.

  1. Scaling parallels in the non-Debye dielectric relaxation of ionic glasses and dipolar supercooled liquids

    International Nuclear Information System (INIS)

    We compare the dielectric response of ionic glasses and dipolar liquids near the glass transition. Our work is divided into two parts. In the first section we examine ionic glasses and the two prominent approaches to analyzing the dielectric response. The conductivity of ion-conducting glasses displays a power law dispersion σ(ω)∝ωn, where n∼0.67, but frequently the dielectric response is analyzed using the electrical modulus M*(ω)=1/var-epsilon *(ω), where var-epsilon *(ω)=var-epsilon(ω)-iσ(ω)/ω is the complex permittivity. We reexamine two specific examples where the shape of M*(ω) changes in response to changes in (a) temperature and (b) ion concentration, to suggest fundamental changes in ion dynamics are occurring. We show, however, that these changes in the shape of M*(ω) occur in the absence of changes in the scaling properties of σ(ω), for which n remains constant. In the second part, we examine the dielectric relaxation found in dipolar liquids, for which var-epsilon *(ω) likewise exhibits changes in shape on approach to the glass transition. Guided by similarities of M*(ω) in ionic glasses and var-epsilon *(ω) in dipolar liquids, we demonstrate that a recent scaling approach proposed by Dixon and co-workers for var-epsilon *(ω) of dipolar relaxation also appears valid for M*(ω) in the ionic case. While this suggests that the Dixon scaling approach is more universal than previously recognized, we demonstrate how the dielectric response can be scaled in a linear manner using an alternative data representation. copyright 1997 The American Physical Society

  2. Commercial-Scale Demonstration of the Liquid Phase Methanol (LPMEOH(TM)) Process

    Energy Technology Data Exchange (ETDEWEB)

    None

    1997-09-30

    The Liquid Phase Methanol (LPMEOH) Demonstration Project at Kingsport, Tennessee, is a $213.7 million cooperative agreement between the U.S. Department of Energy (DOE) and Air Products Liquid Phase Conversion Company, L.P. (the Partnership). Ak Products and Chemicals, Inc. (Air Products) and Eastman Chemical Company (Eastman) formed the Partnership to execute the Demonstration Project. The LPMEOITM Process Demonstration Unit was built at a site located at the Eastman complex in Kingsport. During this reporting period, DOE accepted the recommendation to continue with dimethyl ether (DME) design verification testing (DVT). DME design verification testing studies show the liquid phase DME (LPDME) process will have a significant economic advantage for the coproduction of DME for local markets. An LPDME catalyst system with reasonable long-term activity and stzibility is being developed. Planning for a proof-of-concept test run at the LaPorte Alternative Fuels Development Unit (AFDU) was recommended. DOE issued a letter dated 31 July 1997 accepting the recommendation to continue design verification testing. In order to allow for scale-up of the manufacturing technique for the dehydration catalyst from the pilot plant to the commercial scale, the time required to produce the catalyst to the AFDU has slipped. The new estimated delivery date is 01 June 1998.

  3. Evaporation characteristics of thin film liquid argon in nano-scale confinement: A molecular dynamics study

    Science.gov (United States)

    Hasan, Mohammad Nasim; Shavik, Sheikh Mohammad; Rabbi, Kazi Fazle; Haque, Mominul

    2016-07-01

    Molecular dynamics simulation has been carried out to explore the evaporation characteristics of thin liquid argon film in nano-scale confinement. The present study has been conducted to realize the nano-scale physics of simultaneous evaporation and condensation inside a confined space for a three phase system with particular emphasis on the effect of surface wetting conditions. The simulation domain consisted of two parallel platinum plates; one at the top and another at the bottom. The fluid comprised of liquid argon film at the bottom plate and vapor argon in between liquid argon and upper plate of the domain. Considering hydrophilic and hydrophobic nature of top and bottom surfaces, two different cases have been investigated: (i) Case A: Both top and bottom surfaces are hydrophilic, (ii) Case B: both top and bottom surfaces are hydrophobic. For all cases, equilibrium molecular dynamics (EMD) was performed to reach equilibrium state at 90 K. Then the lower wall was set to four different temperatures such as 110 K, 120 K, 130 K and 140 K to perform non-equilibrium molecular dynamics (NEMD). The variation of temperature and density as well as the variation of system pressure with respect to time were closely monitored for each case. The heat fluxes normal to top and bottom walls were estimated and discussed to illuminate the effectiveness of heat transfer in both hydrophilic and hydrophobic confinement at various boundary temperatures of the bottom plate.

  4. Scaling of liquid-drop impact craters in wet granular media.

    Science.gov (United States)

    Zhang, Qianyun; Gao, Ming; Zhao, Runchen; Cheng, Xiang

    2015-10-01

    Combining high-speed photography with laser profilometry, we study the dynamics and the morphology of liquid-drop impact cratering in wet granular media-a ubiquitous phenomenon relevant to many important geological, agricultural, and industrial processes. By systematically investigating important variables such as impact energy, the size of impinging drops, and the degree of liquid saturation in granular beds, we uncover a scaling law for the size of impact craters. We show that this scaling can be explained by considering the balance between the inertia of impinging drops and the strength of impacted surface. Such a theoretical understanding confirms that the unique energy partition originally proposed for liquid-drop impact cratering in dry granular media also applies for impact cratering in wet granular media. Moreover, we demonstrate that compressive stresses, instead of shear stresses, control the process of granular impact cratering. Our study enriches the picture of generic granular impact cratering and sheds light on the familiar phenomena of raindrop impacts in granular media. PMID:26565233

  5. Small-Scale Coal-Biomass to Liquids Production Using Highly Selective Fischer-Tropsch Synthesis

    Energy Technology Data Exchange (ETDEWEB)

    Gangwal, Santosh K. [Southern Research Institute, Durham, NC (United States); McCabe, Kevin [Southern Research Institute, Durham, NC (United States)

    2015-04-30

    The research project advanced coal-to-liquids (CTL) and coal-biomass to liquids (CBTL) processes by testing and validating Chevron’s highly selective and active cobalt-zeolite hybrid Fischer-Tropsch (FT) catalyst to convert gasifier syngas predominantly to gasoline, jet fuel and diesel range hydrocarbon liquids, thereby eliminating expensive wax upgrading operations The National Carbon Capture Center (NCCC) operated by Southern Company (SC) at Wilsonville, Alabama served as the host site for the gasifier slip-stream testing/demonstration. Southern Research designed, installed and commissioned a bench scale skid mounted FT reactor system (SR-CBTL test rig) that was fully integrated with a slip stream from SC/NCCC’s transport integrated gasifier (TRIGTM). The test-rig was designed to receive up to 5 lb/h raw syngas augmented with bottled syngas to adjust the H2/CO molar ratio to 2, clean it to cobalt FT catalyst specifications, and produce liquid FT products at the design capacity of 2 to 4 L/day. It employed a 2-inch diameter boiling water jacketed fixed-bed heat-exchange FT reactor incorporating Chevron’s catalyst in Intramicron’s high thermal conductivity micro-fibrous entrapped catalyst (MFEC) packing to efficiently remove heat produced by the highly exothermic FT reaction.

  6. Liquid dielectrophoresis and surface microfluidics

    OpenAIRE

    Kaler, Karan V. I. S.; Prakash, Ravi; Chugh, Dipankar

    2010-01-01

    Liquid dielectrophoresis (L-DEP), when deployed at microscopic scales on top of hydrophobic surfaces, offers novel ways of rapid and automated manipulation of very small amounts of polar aqueous samples for microfluidic applications and development of laboratory-on-a-chip devices. In this article we highlight some of the more recent developments and applications of L-DEP in handling and processing of various types of aqueous samples and reagents of biological relevance including emulsions usi...

  7. Multiple time scales in the microscopic dynamics of simple and complex liquids as studied by radiation scattering

    Directory of Open Access Journals (Sweden)

    F.J.Bermejo

    2008-03-01

    Full Text Available Experimental investigations into the time-scales spanned by the microscopic dynamics of simple (metallic and molecular liquids, as explored by neutron scattering and muon spin rotation experiments are reviewed.

  8. Liquid carry-over in an injection moulded all-polymer chip system for immiscible phase magnetic bead-based solid-phase extraction

    DEFF Research Database (Denmark)

    Kistrup, Kasper; Sørensen, Karen Skotte; Wolff, Anders;

    2014-01-01

    We present an all-polymer, single-use microfluidic chip system produced by injection moulding and bonded by ultrasonic welding. Both techniques are compatible with low-cost industrial mass-production. The chip is produced for magnetic bead-based solid-phase extraction facilitated by immiscible...

  9. Liquid-metal pumps for large-scale breeder-reactor plant (prototype pump)

    Energy Technology Data Exchange (ETDEWEB)

    Lindsay, M. (comp.)

    1976-07-01

    This report presents the recommended pump design for use in Large Scale Liquid Metal Fast Breeder Reactor plants. The base design for the pump will circulate 127,000 GPM of liquid sodium at temperatures up to 850/sup 0/F and with a total discharge head at the design point of 500 feet Na with an impeller that is 40 feet below the sodium seal. The pump design is predicated on developing an impeller design which will have a suction specific speed (S/sub n/) of about 20,000 with 20 feet NPSH available, which will result in a pump speed of 530 RPM at design conditions. The design is based on the technology developed in the design and fabrication of FFTF pumps, the design efforts for the Clinch River Breeder Reactor Pump design study and other technology.

  10. Flow control in microfluidic chips : Material choice and smart design

    NARCIS (Netherlands)

    Debrauwer, P.; Emmelkamp, J.; Bolt, P.J.

    2009-01-01

    This paper describes a model and experiments to validate it for the design of bubble free chambers and channels in microfluidic chips. When handling liquids in a microfluidic chip problems may arise with entrapping air or liquid. These air and liquid bubbles deteriorate the efficiency of the process

  11. The extended Beer-Lambert theory for ray tracing modeling of LED chip-scaled packaging application with multiple luminescence materials

    Science.gov (United States)

    Yuan, Cadmus C. A.

    2015-12-01

    Optical ray tracing modeling applied Beer-Lambert method in the single luminescence material system to model the white light pattern from blue LED light source. This paper extends such algorithm to a mixed multiple luminescence material system by introducing the equivalent excitation and emission spectrum of individual luminescence materials. The quantum efficiency numbers of individual material and self-absorption of the multiple luminescence material system are considered as well. By this combination, researchers are able to model the luminescence characteristics of LED chip-scaled packaging (CSP), which provides simple process steps and the freedom of the luminescence material geometrical dimension. The method will be first validated by the experimental results. Afterward, a further parametric investigation has been then conducted.

  12. Rupture mechanism of liquid crystal thin films realized by large-scale molecular simulations.

    Science.gov (United States)

    Nguyen, Trung Dac; Carrillo, Jan-Michael Y; Matheson, Michael A; Brown, W Michael

    2014-03-21

    The ability of liquid crystal (LC) molecules to respond to changes in their environment makes them an interesting candidate for thin film applications, particularly in bio-sensing, bio-mimicking devices, and optics. Yet the understanding of the (in)stability of this family of thin films has been limited by the inherent challenges encountered by experiment and continuum models. Using unprecedented large-scale molecular dynamics (MD) simulations, we address the rupture origin of LC thin films wetting a solid substrate at length scales similar to those in experiment. Our simulations show the key signatures of spinodal instability in isotropic and nematic films on top of thermal nucleation, and importantly, for the first time, evidence of a common rupture mechanism independent of initial thickness and LC orientational ordering. We further demonstrate that the primary driving force for rupture is closely related to the tendency of the LC mesogens to recover their local environment in the bulk state. Our study not only provides new insights into the rupture mechanism of liquid crystal films, but also sets the stage for future investigations of thin film systems using peta-scale molecular dynamics simulations. PMID:24264516

  13. WA105: a large-scale demonstrator of the Liquid Argon double phase TPC

    Science.gov (United States)

    Tonazzo, A.; WA105 Collaboration

    2016-05-01

    The physics case for a large underground detector devoted to neutrino oscillation measurements, nucleon decay and astrophysics is compelling. A time projection chamber based on the dual-phase liquid Argon technique is an extremely attractive option, allowing for long drift distances, low energy threshold and high readout granularity. It has been extensively studied in the LAGUNA-LBNO Design Study and is one of the two designs foreseen for the modules of the DUNE detector in the US. The WA105 experiment envisages the construction of a large scale prototype at CERN, to validate technical solutions and perform physics studies with charged particle beams.

  14. Optical correlator using very-large-scale integrated circuit/ferroelectric-liquid-crystal electrically addressed spatial light modulators

    Science.gov (United States)

    Turner, Richard M.; Jared, David A.; Sharp, Gary D.; Johnson, Kristina M.

    1993-01-01

    The use of 2-kHz 64 x 64 very-large-scale integrated circuit/ferroelectric-liquid-crystal electrically addressed spatial light modulators as the input and filter planes of a VanderLugt-type optical correlator is discussed. Liquid-crystal layer thickness variations that are present in the devices are analyzed, and the effects on correlator performance are investigated through computer simulations. Experimental results from the very-large-scale-integrated / ferroelectric-liquid-crystal optical-correlator system are presented and are consistent with the level of performance predicted by the simulations.

  15. Scaling behaviour and superconducting instability in anisotropic non-Fermi liquids

    CERN Document Server

    Mandal, Ipsita

    2016-01-01

    We study the scaling behaviour of the optical conductivity $(\\sigma)$, free energy density $(F)$ and shear viscosity of the quantum critical point associated with spin density wave phase transition for a two-dimensional metallic system with $C_2$ symmetry. A non-Fermi liquid behaviour emerges at two pairs of isolated points on the Fermi surface due to the coupling of a bosonic order parameter to fermionic excitations at those so-called "hot-spots". We find that near the hot-spots, $\\sigma$ and $F$ obey the scalings expected for such an anisotropic system, and the direction-dependent viscosity to entropy density ratio is not a universal number due to the anisotropy. Lastly, we also estimate the effect of the fermion-boson coupling at the hot-spots on superconducting instabilities.

  16. A robust molecular probe for Ångstrom-scale analytics in liquids.

    Science.gov (United States)

    Nirmalraj, Peter; Thompson, Damien; Dimitrakopoulos, Christos; Gotsmann, Bernd; Dumcenco, Dumitru; Kis, Andras; Riel, Heike

    2016-01-01

    Traditionally, nanomaterial profiling using a single-molecule-terminated scanning probe is performed at the vacuum-solid interface often at a few Kelvin, but is not a notion immediately associated with liquid-solid interface at room temperature. Here, using a scanning tunnelling probe functionalized with a single C60 molecule stabilized in a high-density liquid, we resolve low-dimensional surface defects, atomic interfaces and capture Ångstrom-level bond-length variations in single-layer graphene and MoS2. Atom-by-atom controllable imaging contrast is demonstrated at room temperature and the electronic structure of the C60-metal probe complex within the encompassing liquid molecules is clarified using density functional theory. Our findings demonstrates that operating a robust single-molecular probe is not restricted to ultra-high vacuum and cryogenic settings. Hence the scope of high-precision analytics can be extended towards resolving sub-molecular features of organic elements and gauging ambient compatibility of emerging layered materials with atomic-scale sensitivity under experimentally less stringent conditions. PMID:27516157

  17. Thermodynamic scaling of molecular dynamics in supercooled liquid state of pharmaceuticals: Itraconazole and ketoconazole

    Energy Technology Data Exchange (ETDEWEB)

    Tarnacka, M., E-mail: mtarnacka@us.edu.pl; Madejczyk, O.; Kamiński, K.; Paluch, M. [Institute of Physics, University of Silesia, ul. Uniwersytecka 4, 40-007 Katowice (Poland); Silesian Center of Education and Interdisciplinary Research, University of Silesia, ul. 75 Pulku Piechoty 1A, 41-500 Chorzow (Poland); Adrjanowicz, K. [NanoBioMedical Centre, ul. Umultowska 85, 61-614 Poznan (Poland); Pionteck, J. [Leibniz Institute of Polymer Research Dresden, Hohe Strasse 6, D-01069 Dresden (Germany); Kaminska, E. [Department of Pharmacognosy and Phytochemistry, School of Pharmacy and Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, ul. Jagiellonska 4, 41-200 Sosnowiec (Poland)

    2015-06-14

    Pressure-Volume-Temperature (PVT) measurements and broadband dielectric spectroscopy were carried out to investigate molecular dynamics and to test the validity of thermodynamic scaling of two homologous compounds of pharmaceutical activity: itraconazole and ketoconazole in the wide range of thermodynamic conditions. The pressure coefficients of the glass transition temperature (dT{sub g}/dp) for itraconazole and ketoconazole were determined to be equal to 183 and 228 K/GPa, respectively. However, for itraconazole, the additional transition to the nematic phase was observed and characterized by the pressure coefficient dT{sub n}/dp = 258 K/GPa. From PVT and dielectric data, we obtained that the liquid-nematic phase transition is governed by the relaxation time since it occurred at constant τ {sub α} = 10{sup −5} s. Furthermore, we plotted the obtained relaxation times as a function of T{sup −1}v{sup −γ}, which has revealed that the validity of thermodynamic scaling with the γ exponent equals to 3.69 ± 0.04 and 3.64 ± 0.03 for itraconazole and ketoconazole, respectively. Further analysis of the scaling parameter in itraconazole revealed that it unexpectedly decreases with increasing relaxation time, which resulted in dramatic change of the shape of the thermodynamic scaling master curve. While in the case of ketoconazole, it remained the same within entire range of data (within experimental uncertainty). We suppose that in case of itraconazole, this peculiar behavior is related to the liquid crystals’ properties of itraconazole molecule.

  18. Force-Detected Magnetic Resonance Imaging in Micron-Scale Liquids

    Science.gov (United States)

    Sixta, Aimee; Bogat, Sophia; Wright, Diego; Mozaffari, Shirin; Tennant, Daniel; Paster, Jeremy; Markert, John

    We report our efforts in the development of Nuclear Magnetic Resonance Force Microscopy (NMRFM) for the study of biological materials in liquid media at the micron scale. Our probe contains microfluidic samples sealed in thin-walled (few µm) quartz tubes, with a micro-oscillator sensor nearby in vacuum to maintain its high mechanical resonance quality factor. An initial demonstration utilizes a permalloy magnet on the oscillator tip, which provides a resonant slice of thickness 0.5 µm and an area of diameter 10µm these first measurements aim to demonstrate a single-shot measurement of the longitudinal relaxation time T1 in aqueous solutions of Cu2SO4. We also aim to implement a sawtooth 2? cyclic inversion of the nuclear spins, a detection scheme that effectively eliminates common measurement artifacts. At the micron scale, both spin diffusion and physical diffusion in liquids tend to blur images in conventional magnetic resonance imaging (MRI); we aim to exploit the local nature of the NMRFM probe to obtain higher resolution dynamical images, with the ultimate goal of imaging within individual biological cells.

  19. Large-scale amplitude liquid sloshing in container under pitching excitation

    Institute of Scientific and Technical Information of China (English)

    YUE BaoZeng

    2008-01-01

    Large-scale amplitude liquid sloshing in container under pitching excitation is numerically studied in this paper. Firstly, the kinematics of the ALE description is introduced and the fluid dynamics equations are revised in the ALE form. Secondly, the boundary condition about free-surface tension is represented in the form of weak integration that can be computed by the differential geometry method derived in the present paper and the normal vector on free surface is calculated using accurate formulas presented in this paper. Then the numerical discretized equations of fractional step finite element method are developed by Galerkin weighted residual method. Furthermore, the numerical simulation of large-scale amplitude sloshing of the liquid both in rectangular container and cylindrical container is carried out. The computed time evolution of the wave height, and free surface profiles at different time are obtained. Comparisons among the present numerical results with other published numerical results and experimental data confirm the effectiveness and validity of the method developed in this paper.

  20. Rupture mechanism of liquid crystal thin films realized by large-scale molecular simulations

    Energy Technology Data Exchange (ETDEWEB)

    Nguyen, Trung D [ORNL; Carrillo, Jan-Michael Y [ORNL; Brown, W Michael [ORNL; Matheson, Michael A [ORNL

    2014-01-01

    The ability of liquid crystal (LC) molecules to respond to changes in their environment makes them an interesting candidate for thin film applications, particularly in bio-sensing, bio-mimicking devices, and optics. Yet the understanding of the (in)stability of this family of thin films has been limited by the inherent challenges encountered by experiment and continuum models. Using unprecedented largescale molecular dynamics (MD) simulations, we address the rupture origin of LC thin films wetting a solid substrate at length scales similar to those in experiment. Our simulations show the key signatures of spinodal instability in isotropic and nematic films on top of thermal nucleation, and importantly, for the first time, evidence of a common rupture mechanism independent of initial thickness and LC orientational ordering. We further demonstrate that the primary driving force for rupture is closely related to the tendency of the LC mesogens to recover their local environment in the bulk state. Our study not only provides new insights into the rupture mechanism of liquid crystal films, but also sets the stage for future investigations of thin film systems using peta-scale molecular dynamics simulations.

  1. Nanoslits in silicon chips

    International Nuclear Information System (INIS)

    Potassium hydroxide (KOH) etching of a patterned oriented silicon wafer produces V-shaped etch pits. We demonstrate that the remaining thickness of silicon at the tip of the etch pit can be reduced to ∼5 μm using an appropriately sized etch mask and optical feedback. Starting from such an etched chip, we have developed two different routes for fabricating 100 nm scale slits that penetrate through the macroscopic silicon chip (the slits are ∼850 μm wide at one face of the chip and gradually narrow to ∼100-200 nm wide at the opposite face of the chip). In the first process, the etched chips are sonicated to break the thin silicon at the tip of the etch pit and then further KOH etched to form a narrow slit. In the second process, focused ion beam milling is used to etch through the thin silicon at the tip of the etch pit. The first method has the advantage that it uses only low-resolution technology while the second method offers more control over the length and width of the slit. Our slits can be used for preparing mechanically stable, transmission electron microscopy samples compatible with electrical transport measurements or as nanostencils for depositing nanowires seamlessly connected to their contact pads.

  2. Liquid transportation fuels via large-scale fluidised-bed gasification of lignocellulosic biomass

    Energy Technology Data Exchange (ETDEWEB)

    Hannula, I.; Kurkela, E.

    2013-04-15

    With the objective of gaining a better understanding of the system design trade-offs and economics that pertain to biomass-to-liquids processes, 20 individual BTL plant designs were evaluated based on their technical and economic performance. The investigation was focused on gasification-based processes that enable the conversion of biomass to methanol, dimethyl ether, Fischer-Tropsch liquids or synthetic gasoline at a large (300 MWth of biomass) scale. The biomass conversion technology was based on pressurised steam/O2-blown fluidised-bed gasification, followed by hot-gas filtration and catalytic conversion of hydrocarbons and tars. This technology has seen extensive development and demonstration activities in Finland during the recent years and newly generated experimental data has also been used in our simulation models. Our study included conceptual design issues, process descriptions, mass and energy balances and production cost estimates. Several studies exist that discuss the overall efficiency and economics of biomass conversion to transportation liquids, but very few studies have presented a detailed comparison between various syntheses using consistent process designs and uniform cost database. In addition, no studies exist that examine and compare BTL plant designs using the same front-end configuration as described in this work. Our analysis shows that it is possible to produce sustainable low-carbon fuels from lignocellulosic biomass with first-law efficiency in the range of 49.6-66.7% depending on the end-product and process conditions. Production cost estimates were calculated assuming Nth plant economics and without public investment support, CO2 credits or tax assumptions. They are 58-65 euro/MWh for methanol, 58-66 euro/MWh for DME, 64-75 euro/MWh for Fischer-Tropsch liquids and 68-78 euro/MWh for synthetic gasoline. (orig.)

  3. Temperature and length scale dependence of solvophobic solvation in a single-site water-like liquid

    Science.gov (United States)

    Dowdle, John R.; Buldyrev, Sergey V.; Stanley, H. Eugene; Debenedetti, Pablo G.; Rossky, Peter J.

    2013-02-01

    The temperature and length scale dependence of solvation properties of spherical hard solvophobic solutes is investigated in the Jagla liquid, a simple liquid that consists of particles interacting via a spherically symmetric potential combining a hard core repulsion and a longer ranged soft core interaction, yet exhibits water-like anomalies. The results are compared with equivalent calculations for a model of a typical atomic liquid, the Lennard-Jones potential, and with predictions for hydrophobic solvation in water using the cavity equation of state and the extended simple point charge model. We find that the Jagla liquid captures the qualitative thermodynamic behavior of hydrophobic hydration as a function of temperature for both small and large length scale solutes. In particular, for both the Jagla liquid and water, we observe temperature-dependent enthalpy and entropy of solvation for all solute sizes as well as a negative solvation entropy for sufficiently small solutes at low temperature. This feature of water-like solvation is distinct from the strictly positive and temperature independent enthalpy and entropy of cavity solvation observed in the Lennard-Jones fluid. The results suggest that, compared to a simple liquid, it is the presence of a second thermally accessible repulsive energy scale, acting to increasingly favor larger separations for decreasing temperature, that is the essential characteristic of a liquid that favors low-density, open structures, and models hydrophobic hydration, and that it is the presence of this second energy scale that leads to the similarity in the behavior of water and the Jagla liquid. In addition, the Jagla liquid dewets surfaces of large radii of curvature less readily than the Lennard-Jones liquid, reflecting a greater flexibility or elasticity in the Jagla liquid structure than that of a typical liquid, a behavior also similar to that of water's hydrogen bonding network. The implications of the temperature and

  4. A Review of On-Chip Micro-Evaporation: Experimental Evaluation of Liquid Pumping and Vapor Compression Driven Cooling Systems and Control

    OpenAIRE

    Marcinichen, Jackson Braz; Olivier, Jonathan Albert; Oliveira, Vinícius de; Thome, John Richard

    2011-01-01

    Thermal designers of data centers and server manufacturers are showing a greater concern regarding the cooling of the new generation data centers, which consume considerably more electricity and dissipate much more waste heat, a situation that is creating a re-thinking about the most effective cooling systems for the future beyond conventional air cooling of the chips/servers. A potential significantly better solution is to make use of on-chip two-phase cooling, which, besides improving the ...

  5. Design and Fabrication of the First Commercial-Scale Liquid Phase Methanol (LPMEOH) Reactor

    Energy Technology Data Exchange (ETDEWEB)

    None

    1998-12-21

    The Liquid Phase Methanol (LPMEOHT) process uses a slurry bubble column reactor to convert synthesis gas (syngas), primarily a mixture of carbon monoxide and hydrogen, to methanol. Because of its superior heat management the process can utilize directly the carbon monoxide (CO)-rich syngas characteristic of the gasification of coal, petroleum coke, residual oil, wastes, or other hydrocarbon feedstocks. The LPMEOHM Demonstration Project at Kingsport, Tennessee, is a $213.7 million cooperative agreement between the U.S. Department of Energy (DOE) and Air Products Liquid Phase Conversion Company, L.P., a partnership between Air Products and Chemicals, Inc. and Eastman Chemical Company, to produce methanol from coal-derived syngas. Construction of the LPMEOH~ Process Demonstration Plant at Eastman's chemicals-from-coal complex in Kingsport was completed in January 1997. Following commissioning and shakedown activities, the fwst production of methanol from the facility occurred on April 2, 1997. Nameplate capacity of 260 short tons per day (TPD) was achieved on April 6, 1997, and production rates have exceeded 300 TPD of methanol at times. This report describes the design, fabrication, and installation of the Kingsport LPMEOEFM reactor, which is the first commercial-scale LPMEOEPM reaetor ever built. The vessel is 7.5 feet in diameter and 70 feet tall with design conditions of 1000 psig at 600 `F. These dimensions represent a significant scale-up from prior experience at the DOE-owned Alternative Fuels Development Unit in LaPorte, Texas, where 18-inch and 22-inch diameter reactors have been tested successfidly over thousands of hours. The biggest obstacles discovered during the scale- up, however, were encountered during fabrication of the vessel. The lessons learned during this process must be considered in tailoring the design for future sites, where the reactor dimensions may grow by yet another factor of two.

  6. Determination of the thermodynamic scaling exponent for relaxation in liquids from static ambient-pressure quantities.

    Science.gov (United States)

    Casalini, R; Roland, C M

    2014-08-22

    An equation is derived that expresses the thermodynamic scaling exponent, γ, which superposes relaxation times τ and other measures of molecular mobility determined over a range of temperatures and densities, in terms of static physical quantities. The latter are available in the literature or can be measured at ambient pressure. We show for 13 materials, both molecular liquids and polymers, that the calculated γ are equivalent to the scaling exponents obtained directly by superpositioning. The assumptions of the analysis are that the glass transition T(g) is isochronal (i.e., τ(α) is constant at T(g), which is true by definition) and that the pressure derivative of the glass temperature is given by the first Ehrenfest relation. The latter, derived assuming continuity of the entropy at the glass transition, has been corroborated for many glass-forming materials at ambient pressure. However, we find that the Ehrenfest relation breaks down at elevated pressure; this limitation is of no consequence herein, since the appeal of the new equation is its applicability to ambient-pressure data. The ability to determine, from ambient-pressure measurements, the scaling exponent describing the high-pressure dynamics extends the applicability of this approach to a broader range of materials. Since γ is linked to the intermolecular potential, the new equation thus provides ready access to information about the forces between molecules. PMID:25192107

  7. Entropy-scaling laws for diffusion coefficients in liquid metals under high pressures

    International Nuclear Information System (INIS)

    Molecular dynamic simulations on the liquid copper and tungsten are used to investigate the empirical entropy-scaling laws D*=A exp(BSex), proposed independently by Rosenfeld and Dzugutov for diffusion coefficient, under high pressure conditions. We show that the scaling laws hold rather well for them under high pressure conditions. Furthermore, both the original diffusion coefficients and the reduced diffusion coefficients exhibit an Arrhenius relationship DM=DM0 exp(−EM/KBT), (M=un,R,D) and the activation energy EM increases with increasing pressure, the diffusion pre-exponential factors (DR0 and DD0) are nearly independent of the pressure and element. The pair correlation entropy, S2, depends linearly on the reciprocal temperature S2=−ES/T, and the activation energy, ES, increases with increasing pressure. In particular, the ratios of the activation energies (Eun, ER, and ED) obtained from diffusion coefficients to the activation energy, ES, obtained from the entropy keep constants in the whole pressure range. Therefore, the entropy-scaling laws for the diffusion coefficients and the Arrhenius law are linked via the temperature dependence of entropy

  8. The application of liquid air energy storage for large scale long duration solutions to grid balancing

    Directory of Open Access Journals (Sweden)

    Brett Gareth

    2014-01-01

    Full Text Available Liquid Air Energy Storage (LAES provides large scale, long duration energy storage at the point of demand in the 5 MW/20 MWh to 100 MW/1,000 MWh range. LAES combines mature components from the industrial gas and electricity industries assembled in a novel process and is one of the few storage technologies that can be delivered at large scale, with no geographical constraints. The system uses no exotic materials or scarce resources and all major components have a proven lifetime of 25+ years. The system can also integrate low grade waste heat to increase power output. Founded in 2005, Highview Power Storage, is a UK based developer of LAES. The company has taken the concept from academic analysis, through laboratory testing, and in 2011 commissioned the world's first fully integrated system at pilot plant scale (300 kW/2.5 MWh hosted at SSE's (Scottish & Southern Energy 80 MW Biomass Plant in Greater London which was partly funded by a Department of Energy and Climate Change (DECC grant. Highview is now working with commercial customers to deploy multi MW commercial reference plants in the UK and abroad.

  9. Commercial-Scale Demonstration of the Liquid Phase methanol (LPMEOH) Process A DOE Assessment

    Energy Technology Data Exchange (ETDEWEB)

    National Energy Technology Laboratory

    2003-10-27

    The U.S. Department of Energy (DOE) Clean Coal Technology (CCT) Program seeks to offer the energy marketplace more efficient and environmentally benign coal utilization technology options by demonstrating them in industrial settings. This document is a DOE post-project assessment (PPA) of one of the projects selected in Round III of the CCT Program, the commercial-scale demonstration of the Liquid Phase Methanol (LPMEOH{trademark}) Process, initially described in a Report to Congress by DOE in 1992. Methanol is an important, large-volume chemical with many uses. The desire to demonstrate a new process for the production of methanol from coal, prompted Air Products and Chemicals, Inc. (Air Products) to submit a proposal to DOE. In October 1992, DOE awarded a cooperative agreement to Air Products to conduct this project. In March 1995, this cooperative agreement was transferred to Air Products Liquid Phase Conversion Company, L.P. (the Partnership), a partnership between Air Products and Eastman Chemical Company (Eastman). DOE provided 43 percent of the total project funding of $213.7 million. Operation of the LPMEOH Demonstration Unit, which is sited at Eastman's chemicals-from-coal complex in Kingsport, Tennessee, commenced in April 1997. Although operation of the CCT project was completed in December 2002, Eastman continues to operate the LPMEOH Demonstration Unit for the production of methanol. The independent evaluation contained herein is based primarily on information from Volume 2 of the project's Final Report (Air Products Liquid Phase Conversion Co., L.P. 2003), as well as other references cited.

  10. Chips 2020

    CERN Document Server

    2016-01-01

    The release of this second volume of CHIPS 2020 coincides with the 50th anniversary of Moore’s Law, a critical year marked by the end of the nanometer roadmap and by a significantly reduced annual rise in chip performance. At the same time, we are witnessing a data explosion in the Internet, which is consuming 40% more electrical power every year, leading to fears of a major blackout of the Internet by 2020. The messages of the first CHIPS 2020, published in 2012, concerned the realization of quantum steps for improving the energy efficiency of all chip functions. With this second volume, we review these messages and amplify upon the most promising directions: ultra-low-voltage electronics, nanoscale monolithic 3D integration, relevant-data, brain- and human-vision-inspired processing, and energy harvesting for chip autonomy. The team of authors, enlarged by more world leaders in low-power, monolithic 3D, video, and Silicon brains, presents new vistas in nanoelectronics, promising  Moore-like exponential g...

  11. Isolating Reactions at the Picoliter Scale: Parallel Control of Reaction Kinetics at the Liquid-Liquid Interface.

    Science.gov (United States)

    Phan-Quang, Gia Chuong; Lee, Hiang Kwee; Ling, Xing Yi

    2016-07-11

    Miniaturized liquid-liquid interfacial reactors offer enhanced surface area and rapid confinement of compounds of opposite solubility, yet they are unable to provide in situ reaction monitoring at a molecular level at the interface. A picoreactor operative at the liquid-liquid interface is described, comprising plasmonic colloidosomes containing Ag octahedra strategically assembled at the water-in-decane emulsion interface. The plasmonic colloidosomes isolate ultrasmall amounts of solutions (<200 pL), allowing parallel monitoring of multiple reactions simultaneously. Using the surface-enhanced Raman spectroscopy (SERS) technique, in situ monitoring of the interfacial protonation of dimethyl yellow (p-dimethylaminoazobenzene (DY)) is performed, revealing an apparent rate constant of 0.09 min(-1) for the first-order reaction. The presence of isomeric products with similar physical properties is resolved, which would otherwise be indiscernible by other analytical methods. PMID:27239973

  12. Synthetically chemical-electrical mechanism for controlling large scale reversible deformation of liquid metal objects

    Science.gov (United States)

    Zhang, Jie; Sheng, Lei; Liu, Jing

    2014-11-01

    Reversible deformation of a machine holds enormous promise across many scientific areas ranging from mechanical engineering to applied physics. So far, such capabilities are still hard to achieve through conventional rigid materials or depending mainly on elastomeric materials, which however own rather limited performances and require complicated manipulations. Here, we show a basic strategy which is fundamentally different from the existing ones to realize large scale reversible deformation through controlling the working materials via the synthetically chemical-electrical mechanism (SCHEME). Such activity incorporates an object of liquid metal gallium whose surface area could spread up to five times of its original size and vice versa under low energy consumption. Particularly, the alterable surface tension based on combination of chemical dissolution and electrochemical oxidation is ascribed to the reversible shape transformation, which works much more flexible than many former deformation principles through converting electrical energy into mechanical movement. A series of very unusual phenomena regarding the reversible configurational shifts are disclosed with dominant factors clarified. This study opens a generalized way to combine the liquid metal serving as shape-variable element with the SCHEME to compose functional soft machines, which implies huge potential for developing future smart robots to fulfill various complicated tasks.

  13. Transport of particles in liquid foams: a multi-scale approach

    International Nuclear Information System (INIS)

    Foam is used for the decontamination of radioactive tanks since foam is a system that has a large surface for a low amount of liquid and as a consequence requires less water to be decontaminated. We study experimentally different particle transport configurations in fluid micro-channels network (Plateau borders) of aqueous foam. At first, foam permeability is measured at the scale of a single channel and of the whole foam network for 2 soap solutions known for their significant different interface mobility. Experimental data are well described by a model that takes into account the real geometry of the foam and by considering a constant value of the Boussinesq number of each soap solutions. Secondly, the velocity of one particle convected in a single foam channel is measured for different particle/channel aspect ratio. For small aspect ratio, a counterflow that is taking place at the channel's corners slows down the particle. A recirculation model in the channel foam films is developed to describe this effect. To do this, the Gibbs elasticity is introduced. Then, the threshold between trapped and released of one particle in liquid foam are carried out. This threshold is deduced from hydrodynamic and capillary forces equilibrium. Finally, the case of a clog foam node is addressed. (author)

  14. COMMERCIAL-SCALE DEMONSTRATION OF THE LIQUID PHASE METHANOL (LPMEOH) PROCESS

    Energy Technology Data Exchange (ETDEWEB)

    E.C. Heydorn; B.W. Diamond; R.D. Lilly

    2003-06-01

    This project, which was sponsored by the U.S. Department of Energy (DOE) under the Clean Coal Technology Program to demonstrate the production of methanol from coal-derived synthesis gas (syngas), has completed the 69-month operating phase of the program. The purpose of this Final Report for the ''Commercial-Scale Demonstration of the Liquid Phase Methanol (LPMEOH{trademark}) Process'' is to provide the public with details on the performance and economics of the technology. The LPMEOH{trademark} Demonstration Project was a $213.7 million cooperative agreement between the DOE and Air Products Liquid Phase Conversion Company, L.P. (the Partnership). The DOE's cost share was $92,708,370 with the remaining funds coming from the Partnership. The LPMEOH{trademark} demonstration unit is located at the Eastman Chemical Company (Eastman) chemicals-from-coal complex in Kingsport, Tennessee. The technology was the product of a cooperative development effort by Air Products and Chemicals, Inc. (Air Products) and DOE in a program that started in 1981. Developed to enhance electric power generation using integrated gasification combined cycle (IGCC) technology, the LPMEOH{trademark} Process is ideally suited for directly processing gases produced by modern coal gasifiers. Originally tested at the Alternative Fuels Development Unit (AFDU), a small, DOE-owned process development facility in LaPorte, Texas, the technology provides several improvements essential for the economic coproduction of methanol and electricity directly from gasified coal. This liquid phase process suspends fine catalyst particles in an inert liquid, forming a slurry. The slurry dissipates the heat of the chemical reaction away from the catalyst surface, protecting the catalyst, and allowing the methanol synthesis reaction to proceed at higher rates. The LPMEOH{trademark} Demonstration Project accomplished the objectives set out in the Cooperative Agreement with DOE for this Clean

  15. Monolithic porous polymer stationary phases in polyimide chips for the fast high-performance liquid chromatography separation of proteins and peptides

    OpenAIRE

    Levkin, Pavel A.; Eeltink, Sebastiaan; Stratton, Thomas R.; Brennen, Reid; Robotti, Karla; Yin, Hongfeng; Killeen, Kevin; Svec, Frantisek; Fréchet, Jean M.J.

    2008-01-01

    Poly(lauryl methacrylate-co-ethylene dimethacrylate) and poly(styrene-co-divinylbenzene) stationary phases in monolithic format have been prepared by thermally initiated free radical polymerization within polyimide chips featuring channels having a cross-section of 200×200 μm and a length of 6.8 cm. These chips were then used for the separation of a mixture of proteins including ribonuclease A, myoglobin, cytochrome c, and ovalbumin, as well as peptides. The separations were monitored by UV a...

  16. Experimental testing of reduced-scale seismic isolation bearings for the advanced liquid metal reactor

    International Nuclear Information System (INIS)

    A series of tests of reduced-scale seismic isolation bearings undertaken in support of the development of a seismic isolation concept for the Advanced Liquid Metal Reactor (ALMR) is described. A procurement specification applicable to both full-size and reduced-scale bearings was developed by the program participants and used to purchase bearings of four different designs from two manufacturers. The high-damping rubber isolators were subjected to horizontal, vertical, and failure tests designed to quantify their mechanical properties both within the range of design loads and displacements as well as to establish their margins before failure. The test results show that bearings from both manufacturers provide stable and repeatable behavior with minor variations in stiffness and damping as a function of loading frequency and load history. None of the bearings showed substantial variation in properties due to changes in axial load. All of the bearings exhibited exceptional behavior when loaded beyond the design level, with displacement margins greater than 3 and force margins greater than 4. This test program provides a thorough data-set for further analytical and experimental validations of the seismic isolation concept for the ALMR. (author)

  17. IMPROVED SUBGRID SCALE MODEL FOR DENSE TURBULENT SOLID-LIQUID TWO-PHASE FLOWS

    Institute of Scientific and Technical Information of China (English)

    TANG Xuelin; QIAN Zhongdong; WU Yulin

    2004-01-01

    The dense solid-phase governing equations for two-phase flows are obtained by using the kinetic theory of gas molecules. Assuming that the solid-phase velocity distributions obey the Maxwell equations, the collision term for particles under dense two-phase flow conditions is also derived.In comparison with the governing equations of a dilute two-phase flow, the solid-particle's governing equations are developed for a dense turbulent solid-liquid flow by adopting some relevant terms from the dilute two-phase governing equations. Based on Cauchy-Helmholtz theorem and Smagorinsky model,a second-order dynamic sub-grid-scale (SGS) model, in which the sub-grid-scale stress is a function of both the strain-rate tensor and the rotation-rate tensor, is proposed to model the two-phase governing equations by applying dimension analyses. Applying the SIMPLEC algorithm and staggering grid system to the two-phase discretized governing equations and employing the slip boundary conditions on the walls, the velocity and pressure fields, and the volumetric concentration are calculated. The simulation results are in a fairly good agreement with experimental data in two operating cases in a conduit with a rectangular cross-section and these comparisons imply that these models are practical.

  18. Scale-up of industrial biodiesel production to 40 m3using a liquid lipase formulation

    DEFF Research Database (Denmark)

    Price, Jason; Nordblad, Mathias; Martel, Hannah H.;

    2016-01-01

    In this work, we demonstrate the scale-up from an 80 L fed-batch scale to 40 m3 along with the design of a 4 m3continuous process for enzymatic biodiesel production catalysed by NS-40116 (a liquid formulation of a modified Thermomyces lanuginosus lipase). Based on the analysis of actual pilot plant...... the fed-batch and CSTR cases. Given similar operating conditions, the CSTR operation on average, has a reaction time which is 1.3 times greater than the fed-batch operation. We also showed how the process metrics can be used to quickly estimate the selling price of the enzyme. Assuming a biodiesel selling...... price of 0.6 USD/kg and a one-time use of the enzyme (0.1% (w/woil) enzyme dosage); the enzyme can then be sold for 30 USD/kg which ensures that that the enzyme cost is not more than 5% of the biodiesel revenue. This article is protected by copyright. All rights reserved...

  19. Mineralogical and elemental composition of fly ash from pilot scale fluidised bed combustion of lignite, bituminous coal, wood chips and their blends

    Energy Technology Data Exchange (ETDEWEB)

    Nikolaos Koukouzas; Jouni Hamalainen; Dimitra Papanikolaou; Antti Tourunen; Timo Jantti [Institute for Solid Fuels Technology and Applications, Ptolemais (Greece). Centre for Research and Technology Hellas

    2007-09-15

    The chemical and mineralogical composition of fly ash samples collected from different parts of a laboratory and a pilot scale CFB facility has been investigated. The fabric filter and the second cyclone of the two facilities were chosen as sampling points. The fuels used were Greek lignite (from the Florina basin), Polish coal and wood chips. Characterization of the fly ash samples was conducted by means of X-ray fluorescence (XRF), inductive coupled plasma-optical emission spectrometry (ICP-OES), thermogravimetric analysis (TGA), particle size distribution (PSD) and X-ray diffraction (XRD). According to the chemical analyses the produced fly ashes are rich in CaO. Moreover, SiO{sub 2} is the dominant oxide in fly ash with Al{sub 2}O{sub 3} and Fe{sub 2}O{sub 3} found in considerable quantities. Results obtained by XRD showed that the major mineral phase of fly ash is quartz, while other mineral phases that are occurred are maghemite, hematite, periclase, rutile, gehlenite and anhydrite. The ICP-OES analysis showed rather low levels of trace elements, especially for As and Cr, in many of the ashes included in this study compared to coal ash from fluidised bed combustion in general. 23 refs., 3 figs., 5 tabs.

  20. Copper chip technology

    Science.gov (United States)

    Edelstein, Daniel C.

    1998-09-01

    Recently, IBM announced the first silicon integrated circuit technology that incorporates copper on-chip wiring. This technology, which combines industry-leading CMOS ULSI devices with 6 levels of hierarchically-scaled Cu metallization, has reached the point of manufacturing, after passing the qualification tests required to prove feasibility, yield, reliability, and manufacturability. The discussion of the change from Al To Cu interconnects for ULSI encompasses a wide variety of issues. This paper attempts to address these by way of example, from the broad range of detailed studies that have been performed in the course of developing these so-called 'copper chips.' Motivational issues are covered by comparative modeling of performance aspects and cost. The technology parameters and features are shown, as well as data relating to the process integration, electrical yield and parametric behavior, early manufacturing data, high-frequency modeling and measurements, noise and clock skew. The viability of this technology is indicated by results from reliability stressing, as well as the first successful demonstrations of fully functional SRAM, DRAM, and microprocessor chips with Cu wiring. The advantages of integrated Cu wiring may be applied even more broadly in the future. An example shown here is the achievement of very high-quality integrated inductors; these may help prospects for complete integration of RF and wireless communications chips onto silicon.

  1. Effect of channel size on mass transfer during liquid-liquid plug flow in small scale extractors

    OpenAIRE

    Tsaoulidis, D.; Angeli, P

    2015-01-01

    In this paper the effect of channel size on the mass transfer characteristics of liquid-liquid plug flow was investigated for capillaries with internal diameter ranging from 0.5 to 2 mm. The extraction of {UO2}2+ ions from nitric acid solutions into TBP/IL mixtures, relevant to spent nuclear fuel reprocessing, was studied for different residence times, dispersed phase fractions, and mixture velocities. It was found that extraction efficiencies increased as the channel size decreased. For a gi...

  2. Effectiveness of a controlled release chlorhexidine chip (PerioColTM‑CG as an adjunctive to scaling and root planing when compared to scaling and root planing alone in the treatment of chronic periodontitis: A comparative study

    Directory of Open Access Journals (Sweden)

    Kameswari Kondreddy

    2012-01-01

    Full Text Available Aims and objectives: The aim of this study is to evaluate the effectiveness of a controlled-release chlorhexidine chip as an adjunctive therapy to scaling and root planing when compared with scaling and root planing alone in the treatment of chronic periodontitis. Materials and Methods: 20 patients with a total number of 40 posterior sites were selected. These sites were divided into two groups in a split mouth design,: Group A (control site had 20 sites treated with scaling and root planing alone and Group B (test site had 20 sites treated with scaling and root planing and PerioCol TM -CG. The clinical parameters (Plaque index, bleeding on probing, probing pocket depth, clinical attachment level were recorded at baseline, 90 th and 180 th day for both the groups. Results: When both groups were compared the change in Plaque index was significantly higher in Group B when compared to Group A on the 90 th day and 180 th day. However, there was no statistically significant difference in the mean percentage of gingival bleeding sites between the two groups on the 90 th day, though Group B showed a statistically higher reduction in the mean percentage of gingival bleeding sites at the end of 180 th day. There was no statistically significant difference in probing pocket depth between the two groups on both 90 th and 180 th day. Gain in clinical attachment level was significantly higher in Group B when compared to Group A on the 90 th and 180 th day. Conclusion: From the results observed in this study, it can be concluded that the adjunctive use of PerioCol TM -CG was safe and provided significant improvement in both Plaque index and gingival bleeding index. It was also more favorable than scaling and root planing alone for gain in clinical attachment level.

  3. Future trends in secure chip data managemen

    OpenAIRE

    Anciaux, Nicolas; Bouganim, Luc; Pucheral, Philippe

    2007-01-01

    Secure chips, e.g. present in smart cards, TPM, USB dongles are now ubiquitous in applications with strong security requirements. Secure chips host personal data that must be carefully managed and protected, thus requiring embedded data management techniques. However, secure chips have severe hardware constraints which make traditional database techniques irrelevant. We previously addressed the problem of scaling down database techniques for the smart card and proposed the design of a DBMS ke...

  4. Future Trends in Secure Chip Data Management

    OpenAIRE

    Anciaux, Nicolas; Bouganim, Luc; Pucheral, Philippe

    2007-01-01

    Secure chips, e.g. present in smart cards, TPM, USB dongles are now ubiquitous in applications with strong security requirements. Secure chips host personal data that must be carefully managed and protected, thus requiring embedded data management techniques. However, secure chips have severe hardware constraints which make traditional database techniques irrelevant. We previously addressed the problem of scaling down database techniques for the smart card and proposed the design of a DBMS ke...

  5. Microfluidic chip based nano liquid chromatography coupled to tandem mass spectrometry for the determination of abused drugs and metabolites in human hair.

    Science.gov (United States)

    Zhu, Kevin Y; Leung, K Wing; Ting, Annie K L; Wong, Zack C F; Ng, Winki Y Y; Choi, Roy C Y; Dong, Tina T X; Wang, Tiejie; Lau, David T W; Tsim, Karl W K

    2012-03-01

    A microfluidic chip based nano-HPLC coupled to tandem mass spectrometry (nano-HPLC-Chip-MS/MS) has been developed for simultaneous measurement of abused drugs and metabolites: cocaine, benzoylecgonine, cocaethylene, norcocaine, morphine, codeine, 6-acetylmorphine, phencyclidine, amphetamine, methamphetamine, MDMA, MDA, MDEA, and methadone in the hair of drug abusers. The microfluidic chip was fabricated by laminating polyimide films and it integrated an enrichment column, an analytical column and a nanospray tip. Drugs were extracted from hairs by sonication, and the chromatographic separation was achieved in 15 min. The drug identification and quantification criteria were fulfilled by the triple quardropule tandem mass spectrometry. The linear regression analysis was calibrated by deuterated internal standards with all of the R(2) at least over 0.993. The limit of detection (LOD) and the limit of quantification (LOQ) were from 0.1 to 0.75 and 0.2 to 1.25 pg/mg, respectively. The validation parameters including selectivity, accuracy, precision, stability, and matrix effect were also evaluated here. In conclusion, the developed sample preparation method coupled with the nano-HPLC-Chip-MS/MS method was able to reveal the presence of drugs in hairs from the drug abusers, with the enhanced sensitivity, compared with the conventional HPLC-MS/MS. PMID:22281681

  6. Commercial-Scale Demonstration of the Liquid Phase Methanol (LPMEOTH) Process

    Energy Technology Data Exchange (ETDEWEB)

    None

    1998-12-21

    The Liquid Phase Methanol (LPMEOW) Demonstration Project at Kingsport, Tennessee, is a $213.7 million cooperative agreement between the U.S. Department of Energy (DOE) and Air Products Liquid Phase Conversion Company, L.P. (the Partnership) to produce methanol from coal-derived synthesis gas (syngas). Air Products and Chemicals, Inc. (Air Products) and Eastman Chemical Company (Eastman) formed the Partnership to execute the Demonstration Project. The LPMEOI-P Process Demonstration Unit was built at a site located at the Eastman coal-to-chemicals complex in Kingsport. During this quarter, initial planning and procurement work continued on the seven project sites which have been accepted for participation in the off-site, product-use test program. Approximately 12,000 gallons of fuel-grade methanol (98+ wt% methanol, 4 wt% water) produced during operation on carbon monoxide (CO)-rich syngas at the LPMEOW Demonstration Unit was loaded into trailers and shipped off-site for Mure product-use testing. At one of the projects, three buses have been tested on chemical-grade methanol and on fhel-grade methanol from the LPMEOW Demonstration Project. During the reporting period, planning for a proof-of-concept test run of the Liquid Phase Dimethyl Ether (LPDME~ Process at the Alternative Fuels Development Unit (AFDU) in LaPorte, TX continued. The commercial catalyst manufacturer (Calsicat) has prepared the first batch of dehydration catalyst in large-scale equipment. Air Products will test a sample of this material in the laboratory autoclave. Catalyst activity, as defined by the ratio of the rate constant at any point in time to the rate constant for freshly reduced catalyst (as determined in the laborato~ autoclave), was monitored for the initial extended operation at the lower initial reactor operating temperature of 235oC. At this condition, the decrease in catalyst activity with time from the period 20 December 1997 through 27 January 1998 occurred at a rate of 1.0% per

  7. Laboratory Scale of Liquid Coal Fuel Combustion Process and Exhaust Gas Formation

    Directory of Open Access Journals (Sweden)

    Kartika K. Hendratna

    2010-01-01

    Full Text Available Problem statement: Much research of coal has been already undertaken to ascertain the possibilities of coal being used as substitute for heavy fuel oil in the transportation sector. The effects of using coal as transportation fuel to the environment must also be considered. This study will review several aspects of the coal oil combustion process including combustion behavior, flame stability, some emissions from exhaust gas; CO, NOx and the particulate matter in a well insulated laboratory scale furnace for more stable of combustion. Approach: New way for preparation for liquid coal oil steady combustion on a 2.75 m horizontal boiler with four annular segment tubes, a water jacket system and a system for measurement of water temperature inside was archived. Data was gained by applying liquid coal in the experiment. Detailed preparation and setting for steady combustion of coal oil and formation of the exhaust gas were discussed based on data sampling from four sample points in each centre of the angular tube segments. Results: Preparation for coal oil combustion is an important point in the successful of combustion. Heating coal fuel to than 100°C, heating the fuel line to the same temperature and providing enough air pressure for atomization of coal oil until 0.1 MPa allows coal fuel smoothly atomized in the semi gas phase. There was enough of air combustion via a blower with 4500 L min-1 of flow rate and a 24 L min-1 of water flow rate in the water jacket transforms the energy of the fuel to the heat. Uncolored of the exhaust gas and the physical inspection describes the completion of combustion. This result close-relates with the pollutants formation in the exhaust gas. Conclusion: By conducting a deep research process, there is a chance for the substitute of heavy fuel oil with liquid coal fuel with no special treatment needed in combustion process without ignoring the contribution of the combustion results as an environmental problem.

  8. COST-BENEFIT ANALYSIS OF BIOCONVERSION NEUFCHATEL WHEY INTO RECTIFIED ETHANOL AND ORGANIC LIQUID FERTILIZER IN SEMI PILOT SCALE

    Directory of Open Access Journals (Sweden)

    Gemilang Lara UTAMA

    2015-10-01

    Full Text Available Aims of the study was to determine the cost-benefit analysis in neufchatel whey bioconversion into rectified ethanol and organic liquid fertilizer. Bioconversion whey into rectified ethanol and organic liquid fertilizer has shown great potential as a way to reduce the pollution resulting from cheese-making process. Semi pilot scale experiment was done to ferment 5 L neufchatel whey using 5% K. lactis at 33°C for 24 h in semi anaerobic plastic container without agitation and then distilled into 96.2% purity. Data collected and analyzed descriptively related to benefit cost ratio/BCR, net present value/NPV and internal rate returns/IRR. The result showed that semi pilot scale bioconversion of neufchatel whey resulting in 106.42 ml rectified ethanol and 4404.22 ml distillery residue. Economic benefit could achieved by the support of distillery residue sales as organic liquid fertilizer.

  9. Utilization of a liquid crystal spatial light modulator in a gray scale detour phase method for Fourier holograms.

    Science.gov (United States)

    Makey, Ghaith; El-Daher, Moustafa Sayem; Al-Shufi, Kanj

    2012-11-10

    This paper introduces a new modification for the well-known binary detour phase method, which is largely used to represent Fourier holograms; the modification utilizes gray scale level control provided by a liquid crystal spatial light modulator to improve the traditional binary detour phase. Results are shown by both simulation and experiment. PMID:23142903

  10. COMMODITY SCALE SYNTHESIS OF 1-METHYLIMIDAZOLE BASED IONIC LIQUIDS USING A SPINNING TUBE-IN-TUBE REACTOR

    Science.gov (United States)

    The continuous large-scale preparation of several 1-methylimidazole based ionic liquids was carried out using a Spinning Tube-in-Tube (STT) reactor (manufactured by Kreido Laboratories). This reactor, which embodies and facilitates the use of Green Chemistry principles and Proce...

  11. Multi-scale coarse-graining of non-conservative interactions in molecular liquids

    Energy Technology Data Exchange (ETDEWEB)

    Izvekov, Sergei, E-mail: sergiy.izvyekov.civ@mail.mil; Rice, Betsy M. [U.S. Army Research Laboratory, Aberdeen Proving Ground, Maryland 21005 (United States)

    2014-03-14

    A new bottom-up procedure for constructing non-conservative (dissipative and stochastic) interactions for dissipative particle dynamics (DPD) models is described and applied to perform hierarchical coarse-graining of a polar molecular liquid (nitromethane). The distant-dependent radial and shear frictions in functional-free form are derived consistently with a chosen form for conservative interactions by matching two-body force-velocity and three-body velocity-velocity correlations along the microscopic trajectories of the centroids of Voronoi cells (clusters), which represent the dissipative particles within the DPD description. The Voronoi tessellation is achieved by application of the K-means clustering algorithm at regular time intervals. Consistently with a notion of many-body DPD, the conservative interactions are determined through the multi-scale coarse-graining (MS-CG) method, which naturally implements a pairwise decomposition of the microscopic free energy. A hierarchy of MS-CG/DPD models starting with one molecule per Voronoi cell and up to 64 molecules per cell is derived. The radial contribution to the friction appears to be dominant for all models. As the Voronoi cell sizes increase, the dissipative forces rapidly become confined to the first coordination shell. For Voronoi cells of two and more molecules the time dependence of the velocity autocorrelation function becomes monotonic and well reproduced by the respective MS-CG/DPD models. A comparative analysis of force and velocity correlations in the atomistic and CG ensembles indicates Markovian behavior with as low as two molecules per dissipative particle. The models with one and two molecules per Voronoi cell yield transport properties (diffusion and shear viscosity) that are in good agreement with the atomistic data. The coarser models produce slower dynamics that can be appreciably attributed to unaccounted dissipation introduced by regular Voronoi re-partitioning as well as by larger

  12. Identification and characterisation of factors affecting losses in the large-scale, non-ventilated bulk storage of wood chips and development of best storage practices

    Energy Technology Data Exchange (ETDEWEB)

    Garstang, J.; Weekes, A.; Poulter, R.; Bartlett, D.

    2002-07-01

    The report describes the findings of a study to determine the factors affecting the commercial storage of wood chips for biomass power generation in the UK. The UK's first such plant in North Yorkshire uses a mixture of forestry residues and short rotation coppice (SRC) willow, where problems with the stored fuel highlighted the need to determine best storage practices. Two wood chip piles were built (one with willow chip and the other with wood chips from board leaf forestry residues) and monitored (moisture, temperature, chemical composition, spore numbers and species, heat and air flows, bulk density, etc). Local weather data was also obtained. Recommendations for future storage practices are made.

  13. Analysis on Volatile Compounds in Oak Chips with Medium Toasting Level Using Liquid-liquid Extraction Coupled with Gas Chromatography-mass Spectrometry%应用液液萃取分析中度烘烤橡木片中挥发性化合物

    Institute of Scientific and Technical Information of China (English)

    周双; 徐岩; 范文来; 李记明; 于英; 姜文广; 李兰晓

    2012-01-01

    运用液液萃取与气相色谱.质谱联用技术,研究美国、法国与中国中度烘烤程度橡木片的挥发性化合物。共分离和检测出85种挥发性化合物,包括2种萜烯醇类、1种醛类、7种有机酸类、2种酯类、3种内酯类、7种芳香族类、6种酮类、15种呋喃类、34种酚类,以及8种其他化合物。酚类化合物在橡木中种类较多,浓度较高。定量结果表明,丁香醛、香兰素、糠醛、5-羟甲基糠醛等物质质量浓度较高,对橡木的整体风味影响较大。从呋喃类、橡木内酯、香兰素和丁香醛等化合物比较看,中国橡木与美国橡木类似。%The volatile compounds of oak chips from America, France, and China with medium toasting level were studied by using liquid-liquid extraction coupled with gas chromatography-mass spectrometry. A total of 85 vola- tile compounds were detected and identified, including 2 terpenoid alcohols, 1 aldehyde, 7 fatty acids, 2 esters, 3 lactones, 7 aromatic compounds, 6 ketones, 15 furanic compounds, 34 phenolic compounds, and 8 others. Phenolic compounds had much more amount and concentrations in oak chips. The results showed that the concentrations of sy- ringaldehyde, vanillin, furfural, and 5-hydroxymethylfurfural in oak chips were higher than that of others detected, and these compounds had great impact on the overall aroma and flavor of oak chips. Based on the comparison of furan- ic compounds, whiskey lactones, vanillion, and syringaldehyde, Chinese oak chips were more similar to American oak chips.

  14. Evidence for non-diverging time-scales in glass-forming liquids

    Science.gov (United States)

    McKenna, Gregory

    2013-03-01

    One perceived important signature of the ``ideal'' glass transition and of the complex fluid nature of glass-forming liquids remains the apparent divergence of the dynamics at temperatures above zero Kelvin. Recently, however, this perception has been increasingly challenged both through experiments and in new theories of the dynamics of glass forming systems. In this presentation we summarize some of the prior evidence suggesting that time scales actually do not diverge in glasses that are aged into equilibrium, perhaps 15 K below the conventional glass transition temperature Tg. We then show new results from an extremely densified glass, 20 Ma old Jamaican amber, in which we were able to obtain the upper bound to the relaxation times through a step-wise temperature scan in which the stress relaxation response of the amber was measured both below and above the fictive temperature TF . We find that in the case of the upper bound responses at T>TF , there is a strong deviation of the response from the Super-Arrhenius Vogel-Fulcher behavior and this persists to the fictive temperature which is some 33.8 K below Tg. The results are compared to the parabolic model of Chandler and co-workers and we find the model to be consistent with our results if the value of Tx in the model is taken to be the calorimetric glass transition temperature. The significance of the results will be discussed. We acknowledge NSF grants DMR-0804438 and DMR-1207070 for support of this work

  15. Two-dimensional theoretical electromagnetic analysis for liquid metal flows in a large scale electromagnetic flowmeter

    International Nuclear Information System (INIS)

    Two-dimensional electromagnetic induction equations have been solved for liquid metal flows in a large scale electromagnetic flowmeter taking account of both effects of the velocity profile and the wall conductivity. Theoretical solutions for the scalar potential, the induced current and the induced magnetic filed have been obtained by adopting a fixed velocity function which approximates the overall turbulent flow profile. The distribution of the induced current density shows the eddy current loops, and the return currents exist mostly in the fluid region. The distribution of the induced magnetic field is presented under a condition of a high magnetic Reynolds number. The maximum induced magnetic field is evaluated to be about one order less than the value estimated by a classical method. The vector distribution of the electromagnetic force due to the current and the induced magnetic field is also presented and we found the cancelling effect which prevents this force from becoming a predominant one. Through the analysis of the experiment, it is found the interaction parameter of 0.12 can identify the timing at which the skin friction factor (Cf) begins to increase. Also a discussion is made how the MHD effect will appear. (author)

  16. Electrical processes for the treatment of medium active liquid wastes: a laboratory-scale evaluation

    International Nuclear Information System (INIS)

    A wide range of electrochemical separation processes has been evaluated through literature and experimental studies for potential application to the treatment of medium-active liquid wastes. Of the ten processes considered, electro-osmosis and electrochemical ion-exchange show the most promise for immediate further development to a larger scale, while the faradaic deposition of PuO2, Tc, RuO2 require further laboratory study before judgement can be passed on these. Electro-osmosis has an exceptionally high solids retention (99.99%) and is capable of dewatering suspensions to 35% - suitable for direct incorporation in concrete. Electrochemical ion-exchange has the attractions of a conventional ion-exchange process but with the added features of enhanced kinetics and pH operating range, as well as elution into demineralized water merely by polarity reversal. All electrical processes have the advantage of the added process variable of externally applied potential, which can enable remote, automatic control. (author)

  17. Electrical processes for the treatment of medium-active liquid wastes: a laboratory-scale evaluation

    International Nuclear Information System (INIS)

    A wide range of electrochemical separation processes have been evaluated through the literature and experimental studies for potential application to the treatment of medium-active liquid wastes. Of the 10 processes considered, electro-osmosis and electrochemical ion-exchange show the most promise for immediate further development to a larger scale, while the faradic deposition of PuO2, Tc, RuO2 require further laboratory study before judgment can be passed on these. Electro-osmosis has an exceptionally high solids retention (99.99%) and is capable of dewatering suspensions to 35% - suitable for direct incorporation in concrete. Electrochemical ion-exchange has the attractions of a conventional ion-exchange process but with the added features of enhanced kinetics and pH operating range, as well as elution into demineralized water merely by polarity reversal. All electrical processes have the advantage of the added process variable of externally applied potential, which can enable remote, automatic control

  18. A metallacage encapsulating chloride as a probe for a solvation scale in ionic liquids.

    Science.gov (United States)

    Daguenet, Corinne; Dyson, Paul J

    2007-01-22

    With the purpose of assessing the reactivity of chloride ions dissolved in ionic liquids (ILs), a relative scale for the solvation of chloride is given for a series of ILs based on the bis(trifluoromethane)sulfonimide ([Tf(2)N]) anion and different cations, 1-butyl-3-methylimidazolium ([bmim]), 1-butyl-2,3-dimethylimidazolium ([bdmim]), 1-butyl-1-methylpyrrolidinium ([bmpy]), 1-butylpyridinium ([bpy]), 1-pentyl-1,1,1-triethylammonium ([C(5)e(3)am]), and 1-(2-hydroxy)ethyl-3-methylimidazolium ([mimeOH]). Insights into the solvation of chloride are achieved by the thermodynamic study of the reaction of dissociation of a chloride-templated nickel(II) metallacage performed at various temperatures by UV-visible spectroscopy in each IL. The order of chloride solvation [C(5)e(3)am][Tf(2)N] < [bmpy][Tf(2)N] < [bmim][Tf(2)N]

  19. Gas-liquid two-phase flow structure in the multi-scale weighted complexity entropy causality plane

    Science.gov (United States)

    Tang, Yi; Zhao, An; Ren, Ying-yu; Dou, Fu-Xiang; Jin, Ning-De

    2016-05-01

    The multi-scale weighted complexity entropy causality plane (MS-WCECP) is proposed for characterizing the physical structure of complex system. Firstly we use the method to investigate typical nonlinear time series. Compared with the multi-scale complexity entropy causality plane (MS-CECP), the MS-WCECP can not only uncover the dynamic information loss of complex system with the increase of scale, but also can characterize the complexity of nonlinear dynamic system. In particular, the algorithm of MS-WCECP performs strong anti-noise ability. Then we calculate the MS-WCECP for the conductance fluctuating signals measured from vertical upward gas-liquid two-phase flow experiments in a small diameter pipe, the results demonstrate that the MS-WCECP is a useful approach for exploring the stability and complexity in gas-liquid two-phase flows.

  20. Microstructural Evolution of SAC305 Solder Joints in Wafer Level Chip-Scale Packaging (WLCSP) with Continuous and Interrupted Accelerated Thermal Cycling

    Science.gov (United States)

    Zhou, Quan; Zhou, Bite; Lee, Tae-Kyu; Bieler, Thomas

    2016-06-01

    Four high-strain design wafer level chip scale packages were given accelerated thermal cycling with a 10°C/min ramp rate and 10 min hold times between 0°C and 100°C to examine the effects of continuous and interrupted thermal cycling on the number of cycles to failure. The interruptions given two of the samples were the result of periodic examinations using electron backscattered pattern mapping, leading to room temperature aging of 30 days-2.5 years after increments of about 100 cycles at several stages of the cycling history. The continuous thermal cycling resulted in solder joints with a much larger degree of recrystallization, whereas the interrupted thermal cycling tests led to much less recrystallization, which was more localized near the package side, and the crack was more localized near the interface and had less branching. The failure mode for both conditions was still the same, with cracks nucleating along the high angle grain boundaries formed during recrystallization. In conditions where there were few recrystallized grains, recovery led to formation of subgrains that strengthened the solder, and the higher strength led to a larger driving force for crack growth through the solder, leading to failure after less than half of the cycles in the continuous accelerated thermal cycling condition. This work shows that there is a critical point where sufficient strain energy accumulation will trigger recrystallization, but this point depends on the rate of strain accumulation in each cycle and various recovery processes, which further depends on local crystal orientations, stress state evolution, and specific activated slip and twinning systems.

  1. Development of continuous liquid-fed laboratory-scale mini-melter for nuclear waste glass development

    International Nuclear Information System (INIS)

    A small, continuous liquid-fed mini-melter (LFMM) has been developed at Pacific Northwest Laboratory (PNL) to aid in waste glass feed slurry development. The LFMM offers several advantages over testing in large-scale melters. The LFMM requires little lead time in preparing for a test run, and the labor and material requirements are low. Real-time melting behavior of liquid feed slurries can be investigated, and feed rates can be estimated for larger-scale melters. The glass produced is representative of that produced by a larger-scale melter, as well as representative of the processing operation itself. Glass produced by the LFMM may subsequently be analyzed for metallic and other secondary phase formation. In contrast to larger-scale melters, the LFMM may be easily and inexpensively installed in a hot cell because of its relatively small size and simple configuration, enabling testing of radioactive feeds. A total of six LFMM experimental runs were performed. Feeds were obtained which corresponded to PNL melter runs performed in larger PNL developmental joule-heated research melters. These nonradioactive liquid-fed ceramic melters are known as the High-Bay Ceramic Melter (HBCM), the Experimental Ceramic Melter (ECM), and the Pilot-Scale Ceramic Melter (PSCM). Preliminary results obtained with the limited testing are promising. Feeds processed in the LFMM exhibited behavior closely resembling that observed in the large-scale melters. Feed rate correlations between the LFMM and ECM, HBCM, and PSCM were developed to estimate a range of expected feed rates for the large-scale melters from LFMM data. More developmental work with LFMM testing needs to be completed. Further testing will eliminate bias and establish the LFMM's true correlation to, and representation of, large-scale melters

  2. A review of on-chip micro-evaporation: Experimental evaluation of liquid pumping and vapor compression driven cooling systems and control

    International Nuclear Information System (INIS)

    Thermal designers of data centers and server manufacturers are showing a greater concern regarding the cooling of the new generation data centers, which consume considerably more electricity and dissipate much more waste heat, a situation that is creating a re-thinking about the most effective cooling systems for the future beyond conventional air cooling of the chips/servers. A potential significantly better solution is to make use of on-chip two-phase cooling, which, besides improving the cooling performance at the chip level, also adds the capability to reuse the waste heat in a convenient manner, since higher evaporating and condensing temperatures of the two-phase cooling system (from 60 to 95 °C) are possible with such a new “green” cooling technology. In the present project, two such two-phase cooling cycles using micro-evaporation technology were experimentally evaluated with specific attention being paid to (i) controllability of the two-phase cooling system, (ii) energy consumption and (iii) overall exergetic efficiency. The controllers were evaluated by tracking and disturbance rejection tests, which were shown to be efficient and effective. The average temperatures of the chips were maintained below the limit of 85 °C for all tests evaluated in steady state and transient conditions. In general, simple SISO strategies were sufficient to attain the requirements of control. Regarding energy and exergy analyses, the experimental results showed that both systems can be thermodynamically improved since only about 10% of the exergy supplied is in fact recovered in the condenser in the present setup.

  3. Design of a Liquid Crystal Display System for the Single Chip Microcomputer%单片机液晶显示系统的设计

    Institute of Scientific and Technical Information of China (English)

    段新燕

    2012-01-01

    以C8051F单片机和液晶显示控制器KS0108为核心,设计了单片机控制的液晶显示系统。重点研究了图形的动态显示技术,介绍了液晶显示模块的硬件、软件特性。文中设计的电路在C8051F020单片机仿真实验系统上进行了仿真,实验结果表明,设计达到了预期目标。%This article introduces the C8051F single-chip micro-computer and the LCD controller KS0108. U- sing them as the core, we have designed the single-chip micro-computer LCD system. In the thesis, we put empha- sis on the technology of graphic dynamic display, and describe the LCM's hardware and software features. The cir- cuit that we have designed is emulated in the C8051F020 single-chip micro-computer emulation experiment system. That experimental result shows that we have achieved the expected goal in the design.

  4. ArDM: a ton-scale liquid Argon experiment for direct detection of Dark Matter in the Universe

    International Nuclear Information System (INIS)

    The ArDM project aims at developing and operating large noble liquid detectors to search for direct evidence of Weakly Interacting Massive Particle (WIMP) as Dark Matter in the Universe. The initial goal is to design, assemble and operate a ∼1 ton liquid Argon prototype to demonstrate the feasibility of a ton-scale experiment with the required performance to efficiently detect and sufficiently discriminate backgrounds for a successful WIMP detection. Our design addresses the possibility to detect independently ionization and scintillation signals. In this paper, we describe this goal and the conceptual design of the detector

  5. On the density scaling of pVT data and transport properties for molecular and ionic liquids

    Science.gov (United States)

    López, Enriqueta R.; Pensado, Alfonso S.; Fernández, Josefa; Harris, Kenneth R.

    2012-06-01

    In this work, a general equation of state (EOS) recently derived by Grzybowski et al. [Phys. Rev. E 83, 041505 (2011)] is applied to 51 molecular and ionic liquids in order to perform density scaling of pVT data employing the scaling exponent γEOS. It is found that the scaling is excellent in most cases examined. γEOS values range from 6.1 for ammonia to 13.3 for the ionic liquid [C4C1im][BF4]. These γEOS values are compared with results recently reported by us [E. R. López, A. S. Pensado, M. J. P. Comuñas, A. A. H. Pádua, J. Fernández, and K. R. Harris, J. Chem. Phys. 134, 144507 (2011)] for the scaling exponent γ obtained for several different transport properties, namely, the viscosity, self-diffusion coefficient, and electrical conductivity. For the majority of the compounds examined, γEOS > γ, but for hexane, heptane, octane, cyclopentane, cyclohexane, CCl4, dimethyl carbonate, m-xylene, and decalin, γEOS carbonate and 1-methylnaphthalene. Therefore, it seems the relation proposed by Paluch et al. applies only in certain cases, and is really not generally applicable to liquid transport properties such as viscosities, self-diffusion coefficients or electrical conductivities when examined over broad ranges of temperature and pressure.

  6. Full-scale performance of new organic resin ratios and inorganic materials for processing low level liquids at Diablo Canyon Power Plant

    International Nuclear Information System (INIS)

    This paper discusses Pacific Gas and Electric Company's full-scale operating experience using new ion exchange resins and rations for processing radioactive liquids at Diablo Canyon Power Plant (DCPP). Previous tests investigated new organic resins, various resin ratios and several ion selective inorganic media for processing nonrecyclable and recyclable plant liquids. The data from those bench scale tests indicated how processing liquids at DCPP could be improved. Information obtained from the bench scale tests have been directly applied to full-scale operation throughout 1989. Processing nonrecyclable and recyclable liquids prior to the bench scale tests utilized a 50:50 mixed bed (Amberlite IRN-150) ion exchange resin. The full-scale test of new media effectively processed more liquid at higher conductivities than previously experienced. Optimizing the cation and anion ratios has improved the removal of radionuclides and chemical species for specific liquid streams. The use of polyelectrolyte pretreatment in full-scale processing has enhanced the radionuclide decontamination for nonrecyclable liquids. The combination of these applications has improved the ion exchange process for treating nonrecyclable and recyclable liquids at DCPP. 1 ref., 2 figs., 1 tab

  7. Performance and Energy Efficient Network-on-Chip Architectures

    OpenAIRE

    Vangal, Sriram

    2007-01-01

    The scaling of MOS transistors into the nanometer regime opens the possibility for creating large Network-on-Chip (NoC) architectures containing hundreds of integrated processing elements with on-chip communication. NoC architectures, with structured on-chip networks are emerging as a scalable and modular solution to global communications within large systems-on-chip. NoCs mitigate the emerging wire-delay problem and addresses the need for substantial interconnect bandwidth by replacing today...

  8. Permeability of fiber reinforcements for liquid composite molding: Sequential multi-scale investigations into numerical flow modeling on the micro- and meso-scale

    Science.gov (United States)

    Luchini, Timothy John Franklin

    Composites are complex material mixtures, known to have high amounts of variability, with unique properties at the micro-, meso-, and macro-scales. In the context of advanced textile composite reinforcements, micro-scale refers to aligned fibers and toughening agents in a disordered arrangement; meso-scale is the woven, braided, or stitched fabric geometry (which compacts to various volume fractions); and macro-scale is the component or sub-component being produced for a mechanical application. The Darcy-based permeability is an important parameter for modeling and understanding the flow profile and fill times for liquid composite molding. Permeability of composite materials can vary widely from the micro- to macro-scales. For example, geometric factors like compaction and ply layup affect the component permeability at the meso- and macro-scales. On the micro-scale the permeability will be affected by the packing arrangement of the fibers and fiber volume fraction. On any scale, simplifications to the geometry can be made to treat the fiber reinforcement as a porous media. Permeability has been widely studied in both experimental and analytical frameworks, but less attention has focused on the ability of numerical tools to predict the permeability of reinforced composite materials. This work aims at (1) predicting permeability at various scales of interest and (2) developing a sequential, multi-scale, numerical modeling approach on the micro- and meso-scales. First, a micro-scale modeling approach is developed, including a geometry generation tool and a fluids-based numerical permeability solver. This micro-scale model included all physical fibers and derived the empirical permeability constant directly though numerical simulation. This numerical approach was compared with literature results for perfect packing arrangements, and the results were shown to be comparable with previous work. The numerical simulations described here also extended these previous

  9. Silicon chips light up

    International Nuclear Information System (INIS)

    Researchers have demonstrated a continuous laser in silicon, which paves the way for computing at the speed of light Silicon is the racehorse of microelectronics. For the last 40 years, the number of transistors that can be crammed onto a single silicon wafer has doubled every 18 months or so, with the latest 'Itanium' chip packing in almost half a billion of them. But Moore's law, as this exponential trend is popularly known, is coming to an end due to fundamental physical limitations. These include the difficulty of keeping the chips cool and the fact that length scales are quickly approaching those of a single atom. A silicon laser could help chip makers beat these limitations by harnessing light, thus reducing the size and cost of microelectronic circuits even further,while at the same time increasing their speed. The problem is that silicon is a very inefficient light emitter, which means that silicon-based optoelectronics has remained out of reach. Since 2000 all this has changed and the race to build a silicon laser has begun in earnest. Now, Mario Paniccia and colleagues at Intel in the US and Israel have demonstrated the first continuous all-silicon laser by harnessing a phenomenon called Raman scattering (Nature 433 292 and 725). (U.K.)

  10. Current-driven flow instabilities in large-scale liquid metal batteries, and how to tame them

    CERN Document Server

    Weber, Norbert; Stefani, Frank; Weier, Tom

    2013-01-01

    The use of liquid metal batteries is considered as one promising option for electric grid stabilisation. While large versions of such batteries are preferred in view of the economies of scale, they are susceptible to various magnetohydrodynamic instabilities which imply a risk of short-circuiting the battery due to the triggered fluid flow. Here we focus on the current driven Tayler instability and give critical electrical currents for its onset as well as numerical estimates for the appearing flow structures and speeds. Scaling laws for different materials, battery sizes and geometries are found. We further discuss and compare various means for preventing the instability.

  11. Tunable on chip optofluidic laser

    DEFF Research Database (Denmark)

    Bakal, Avraham; Vannahme, Christoph; Kristensen, Anders;

    2015-01-01

    A chip scale tunable laser in the visible spectral band is realized by generating a periodic droplet array inside a microfluidic channel. Combined with a gain medium within the droplets, the periodic structure provides the optical feedback of the laser. By controlling the pressure applied to two...

  12. Final Report Full-Scale Test of DWPF Advanced Liquid-Level and Density Measurement Bubblers

    International Nuclear Information System (INIS)

    As requested by the Technical Task Request (1), a full-scale test was carried out on several different liquid-level measurement bubblers as recommended from previous testing (2). This final report incorporates photographic evidence (Appendix B) of the bubblers at different stages of testing, along with the preliminary results (Appendix C) which were previously reported (3), and instrument calibration data (Appendix D); while this report contains more detailed information than previously reported (3) the conclusions remain the same. The test was performed under highly prototypic conditions from November 26, 1996 to January 23, 1997 using the full-scale SRAT/SME tank test facilities located in the 672-T building at TNX. Two different types of advanced bubblers were subjected to approximately 58 days of slurry operation; 14 days of which the slurry was brought to boiling temperatures.The test showed that the large diameter tube bubbler (2.64 inches inside diameter) operated successfully throughout the2-month test by not plugging with the glass-frit ladened slurry which was maintained at a minimum temperature of 50 deg Cand several days of boiling temperatures. However, a weekly blow-down with air or water is recommended to minimize the slurry which builds up.The small diameter porous tube bubbler (0.62 inch inside diameter; water flow > 4 milliliters/hour = 1.5 gallons/day) operated successfully on a daily basis in the glass-frit ladened slurry which was maintained at a minimum temperature of 50 degrees C and several days of boiling temperatures. However, a daily blow-down with air, or air and water, is necessary to maintain accurate readings.For the small diameter porous tube bubbler (0.62 inch inside diameter; water flow > 4 milliliters/hour = 1.5 gallons/day) there were varying levels of success with the lower water-flow tubes and these tubes would have to be cleaned by blowing with air, or air and water, several times a day to maintain them plug free. This may be

  13. Final Report Full-Scale Test of DWPF Advanced Liquid-Level and Density Measurement Bubblers

    Energy Technology Data Exchange (ETDEWEB)

    Duignan, M.R. [Westinghouse Savannah River Company, AIKEN, SC (United States); Weeks, G.E.

    1999-07-01

    As requested by the Technical Task Request (1), a full-scale test was carried out on several different liquid-level measurement bubblers as recommended from previous testing (2). This final report incorporates photographic evidence (Appendix B) of the bubblers at different stages of testing, along with the preliminary results (Appendix C) which were previously reported (3), and instrument calibration data (Appendix D); while this report contains more detailed information than previously reported (3) the conclusions remain the same. The test was performed under highly prototypic conditions from November 26, 1996 to January 23, 1997 using the full-scale SRAT/SME tank test facilities located in the 672-T building at TNX. Two different types of advanced bubblers were subjected to approximately 58 days of slurry operation; 14 days of which the slurry was brought to boiling temperatures.The test showed that the large diameter tube bubbler (2.64 inches inside diameter) operated successfully throughout the2-month test by not plugging with the glass-frit ladened slurry which was maintained at a minimum temperature of 50 deg Cand several days of boiling temperatures. However, a weekly blow-down with air or water is recommended to minimize the slurry which builds up.The small diameter porous tube bubbler (0.62 inch inside diameter; water flow {gt} 4 milliliters/hour = 1.5 gallons/day) operated successfully on a daily basis in the glass-frit ladened slurry which was maintained at a minimum temperature of 50 degrees C and several days of boiling temperatures. However, a daily blow-down with air, or air and water, is necessary to maintain accurate readings.For the small diameter porous tube bubbler (0.62 inch inside diameter; water flow {gt} 4 milliliters/hour = 1.5 gallons/day) there were varying levels of success with the lower water-flow tubes and these tubes would have to be cleaned by blowing with air, or air and water, several times a day to maintain them plug free. This

  14. Micro-fluidic tools for the liquid-liquid extraction of radionuclides in analytical procedures

    International Nuclear Information System (INIS)

    The analyses of radionuclides are in great demand and a cost effective technique for the separation of analytes is required. A micro-scale reactor composed of microchannels fabricated in a microchip was chosen to investigate liquid-liquid extraction reactions driven by three different families of metal extractants: neutral, acidic and ion-pair extractants. The extraction conditions in the micro-fluidic device were considered. These investigations demonstrated that the conventional methodology used for solvent extraction in macro-scale reactors is not directly transposable to micro liquid-liquid extraction systems. However, it is expected that the understanding of the chemical and physical phenomena involved in a reference extraction systems studied in a given selected lab-on-chip will lead us to develop and validate a methodology suitable to miniaturized reactors. (authors)

  15. Kinetically engendered sub-spinodal length scales in spontaneous dewetting of thin liquid films

    OpenAIRE

    Kotni, TirumalaRao; Sarkar, Jayati; Khanna, Rajesh

    2014-01-01

    Numerical simulations of spontaneous dewetting of non-slipping, variable viscosity unstable thin liquid films on homogeneous substrates reveal the existence of sub-spinodal lengthscales through formation of satellite holes, a marker of nucleated dewetting and/or heterogeneous substrates, in the late stages of dewetting if the liquid viscosity decreases continually with decreasing film thickness. These films also show established signatures of slipping films such as faster rupture and flatter ...

  16. Preparation for full scale demonstration of an air staged gasifier plant. Technical project development; For combined heat and power production with wood chips; Forberedelse til fuldskala demonstration af trinopdelt forgasningsanlaeg. Teknisk projektudvikling. Delrapport

    Energy Technology Data Exchange (ETDEWEB)

    Houmann Jakobsen, H.

    2011-04-15

    The project has aimed to further develop the technology for staged biomass gasification and establish an organizational and financial model to ensure that the technology can be introduced on the market. This report describes the technique in an upcoming demonstration plant. A complete planning and design of a demonstration plant with a capacity of 300 kW electric power and 700 kW heat was prepared. That is four times more than the pilot plant at Graested District Heating (Castor plant) can produce. A full scale demonstration plant with bio-gasification technology for wood chips will be established and put into operation in 2012. (ln)

  17. Scaling relation and regime map of explosive gas–liquid flow of binary Lennard-Jones particle system

    KAUST Repository

    Inaoka, Hajime

    2012-02-01

    We study explosive gasliquid flows caused by rapid depressurization using a molecular dynamics model of Lennard-Jones particle systems. A unique feature of our model is that it consists of two types of particles: liquid particles, which tend to form liquid droplets, and gas particles, which remain supercritical gaseous states under the depressurization realized by simulations. The system has a pipe-like structure similar to the model of a shock tube. We observed physical quantities and flow regimes in systems with various combinations of initial particle number densities and initial temperatures. It is observed that a physical quantity Q, such as pressure, at position z measured along a pipe-like system at time t follows a scaling relation Q(z,t)=Q(zt) with a scaling function Q(ζ). A similar scaling relation holds for time evolution of flow regimes in a system. These scaling relations lead to a regime map of explosive flows in parameter spaces of local physical quantities. The validity of the scaling relations of physical quantities means that physics of equilibrium systems, such as an equation of state, is applicable to explosive flows in our simulations, though the explosive flows involve highly nonequilibrium processes. In other words, if the breaking of the scaling relations is observed, it means that the explosive flows cannot be fully described by physics of equilibrium systems. We show the possibility of breaking of the scaling relations and discuss its implications in the last section. © 2011 Elsevier B.V. All rights reserved.

  18. Wood chip delivery and research project at Mikkeli region

    International Nuclear Information System (INIS)

    In 1994, a large-scale energywood production chain was started as a co-operation project by the Mikkeli city forest office and local forestry societies. Over 60 000 m3 (about 46 000 MWh of energy) of forest processed chips were delivered to Pursiala heat and power plant in Mikkeli. About 60 % of these chips was whole tree chips from improvement cuttings of young forest stands and the rest was logging waste chips from regeneration cutting areas. The average total delivery costs of forest processed chips after reduction of energywood and other subsidies were approximately 51 FIM/m3 (68 FIM/MWh) for the whole tree chips and 40 FIM/m3 (53 FIM/MWh) for logging waste chips. The delivery costs of wood chips could compete with those of fuel peat only in the most favourable cases. The resources of forest processed chips were studied on the basis of forestry plans. According to the study, there is enough raw material for permanent, large-scale delivery of forest processed chips (up to 250 000 m3/a) in the forests located at a distance of under 40 road kilometers from the Pursiala heat and power plant. The following project stages will involve further development of the wood chip delivery chain logistics, as well as improvement of logging and chipping equipment and methods in energywood and logging waste production. Also the effects of wood energy production on the economy and environment of the whole Mikkeli region will be studied. (author)

  19. Advanced Liquid-Free, Piezoresistive, SOI-Based Pressure Sensors for Measurements in Harsh Environments

    Directory of Open Access Journals (Sweden)

    Ha-Duong Ngo

    2015-08-01

    Full Text Available In this paper we present and discuss two innovative liquid-free SOI sensors for pressure measurements in harsh environments. The sensors are capable of measuring pressures at high temperatures. In both concepts media separation is realized using a steel membrane. The two concepts represent two different strategies for packaging of devices for use in harsh environments and at high temperatures. The first one is a “one-sensor-one-packaging_technology” concept. The second one uses a standard flip-chip bonding technique. The first sensor is a “floating-concept”, capable of measuring pressures at temperatures up to 400 °C (constant load with an accuracy of 0.25% Full Scale Output (FSO. A push rod (mounted onto the steel membrane transfers the applied pressure directly to the center-boss membrane of the SOI-chip, which is placed on a ceramic carrier. The chip membrane is realized by Deep Reactive Ion Etching (DRIE or Bosch Process. A novel propertied chip housing employing a sliding sensor chip that is fixed during packaging by mechanical preloading via the push rod is used, thereby avoiding chip movement, and ensuring optimal push rod load transmission. The second sensor can be used up to 350 °C. The SOI chips consists of a beam with an integrated centre-boss with was realized using KOH structuring and DRIE. The SOI chip is not “floating” but bonded by using flip-chip technology. The fabricated SOI sensor chip has a bridge resistance of 3250 Ω. The realized sensor chip has a sensitivity of 18 mV/µm measured using a bridge current of 1 mA.

  20. Surface modification and characterization for dispersion stability of inorganic nanometer-scaled particles in liquid media

    Directory of Open Access Journals (Sweden)

    Hidehiro Kamiya and Motoyuki Iijima

    2010-01-01

    Full Text Available Inorganic nanoparticles are indispensable for science and technology as materials, pigments and cosmetics products. Improving the dispersion stability of nanoparticles in various liquids is essential for those applications. In this review, we discuss why it is difficult to control the stability of nanoparticles in liquids. We also overview the role of surface interaction between nanoparticles in their dispersion and characterization, e.g. by colloid probe atomic force microscopy (CP-AFM. Two types of surface modification concepts, post-synthesis and in situ modification, were investigated in many previous studies. Here, we focus on post-synthesis modification using adsorption of various kinds of polymer dispersants and surfactants on the particle surface, as well as surface chemical reactions of silane coupling agents. We discuss CP-AFM as a technique to analyze the surface interaction between nanoparticles and the effect of surface modification on the nanoparticle dispersion in liquids.

  1. Studies with a liquid argon time projection chamber. Addressing technological challenges of large-scale detectors

    International Nuclear Information System (INIS)

    Michael Schenk evaluates new technologies and methods, such as cryogenic read-out electronics and a UV laser system, developed to optimise the performance of large liquid argon time projection chambers (LArTPC). Amongst others, the author studies the uniformity of the electric field produced by a Greinacher high-voltage generator operating at cryogenic temperatures, measures the linear energy transfer (LET) of muons and the longitudinal diffusion coefficient of electrons in liquid argon. The results are obtained by analysing events induced by cosmic-ray muons and UV laser beams. The studies are carried out with ARGONTUBE, a prototype LArTPC in operation at the University of Bern, Switzerland, designed to investigate the feasibility of drift distances of up to five metres for electrons in liquid argon.

  2. Tests of reduced-scale seismic isolation bearings for the U.S. Advanced Liquid Metal Reactor (ALMR) program

    International Nuclear Information System (INIS)

    This paper summarizes a portion of a thorough series of tests on several different designs of reduced-scale high damping rubber isolators for the U.S. Advanced Liquid Metal Reactor (ALMR) program. A formal procurement specification has been developed by the program participants for purchasing bearings of several different scale factors and designs. The reduced-scale bearings in the specification have geometric scale factors of 1/4 and 1/8 so that dynamic tests can be performed at realistic rates, The 1/8-scale bearings also have a range of rubber layer thicknesses so that the effects of shape factor on mechanical properties may be determined. Tests of bearings from two suppliers using one of the 1/8-scale bearing designs are summarized here. The test program includes horizontal shear tests to moderate and high shear strains at a range of axial loads and frequencies, as well as vertical tests and failure tests to quantify the margin of safety in the actual design. Load-History effects including short-term stiffness reduction and long-term stiffness recovery are also under study. The primary focus of these tests is on characterizing the behavior of the compounds proposed by the bearing suppliers

  3. Tests of reduced-scale seismic isolation bearings for the U.S. Advanced Liquid Metal Reactor (ALMR) program

    Energy Technology Data Exchange (ETDEWEB)

    Clark, P.W.; Aiken, I.D.; Kelly, J.M. [Univ. of California, Berkeley, CA (United States). Earthquake Engineering Research Center; Gluekler, E.L. [General Electric Co., San Jose, CA (United States); Tajirian, F.F. [Bechtel National Corp., San Francisco, CA (United States)

    1995-12-01

    This paper summarizes a portion of a thorough series of tests on several different designs of reduced-scale high damping rubber isolators for the U.S. Advanced Liquid Metal Reactor (ALMR) program. A formal procurement specification has been developed by the program participants for purchasing bearings of several different scale factors and designs. The reduced-scale bearings in the specification have geometric scale factors of 1/4 and 1/8 so that dynamic tests can be performed at realistic rates, The 1/8-scale bearings also have a range of rubber layer thicknesses so that the effects of shape factor on mechanical properties may be determined. Tests of bearings from two suppliers using one of the 1/8-scale bearing designs are summarized here. The test program includes horizontal shear tests to moderate and high shear strains at a range of axial loads and frequencies, as well as vertical tests and failure tests to quantify the margin of safety in the actual design. Load-History effects including short-term stiffness reduction and long-term stiffness recovery are also under study. The primary focus of these tests is on characterizing the behavior of the compounds proposed by the bearing suppliers.

  4. Electromagnetic liquid pistons for capillarity-based pumping.

    Science.gov (United States)

    Malouin, Bernard A; Vogel, Michael J; Olles, Joseph D; Cheng, Lili; Hirsa, Amir H

    2011-02-01

    The small scales associated with lab-on-a-chip technologies lend themselves well to capillarity-dominated phenomena. We demonstrate a new capillarity-dominated system where two adjoining ferrofluid droplets can behave as an electronically-controlled oscillator or switch by an appropriate balance of magnetic, capillary, and inertial forces. Their oscillatory motion can be exploited to displace a surrounding liquid (akin to an axial piston pump), forming electromagnetic "liquid pistons." Such ferrofluid pistons can pump a precise volume of liquid via finely tunable amplitudes (cf. pump stroke) or resonant frequencies (cf. pump speed) with no solid moving parts for long-term operation without wear in a small device. Furthermore, the rapid propagation of electromagnetic fields and the favorable scaling of capillary forces with size permit micron sized devices with very fast operating speeds (∼kHz). The pumping dynamics and performance of these liquid pistons is explored, with experimental measurements showing good agreement with a spherical cap model. While these liquid pistons may find numerous applications in micro- and mesoscale fluidic devices (e.g., remotely activated drug delivery), here we demonstrate the use of these liquid pistons in capillarity-dominated systems for chip-level, fast-acting adaptive liquid lenses with nearly perfect spherical interfaces. PMID:21127823

  5. The ArDM, a ton-scale liquid argon experiment for direct dark matter detection

    International Nuclear Information System (INIS)

    Full text: The ArDM is a 1-ton liquid argon based experiment which aims at the direct detection of Weakly Interacting Massive Particles (WIMPs). The detector is sensitive to the small signals of scintillation light and the ionization charge independently. The sufficient discrimination between nuclear recoils and the background is possible by the ratio of scintillation to ionization and by the different time structure of the scintillation. In the present time the experiment is under construction at CERN. The detector was recently tested being fully filled with Liquid Argon. Promising results on the light yield and on the detector performance were obtained. (author)

  6. Microfluidics without channels: highly-flexible synthesis on a digital-microfluidic chip for production of diverse PET tracers

    Energy Technology Data Exchange (ETDEWEB)

    Van Dam, Robert Michael [Univ. of California, Los Angeles, CA (United States)

    2010-09-01

    Positron emission tomography (PET) imaging is used for fundamental studies of living biological organisms and microbial ecosystems in applications ranging from biofuel production to environmental remediation to the study, diagnosis, and treatment monitoring of human disease. Routine access to PET imaging, to monitor biochemical reactions in living organisms in real time, could accelerate a broad range of research programs of interest to DOE. Using PET requires access to short-lived radioactive-labeled compounds that specifically probe the desired living processes. The overall aims of this project were to develop a miniature liquid-handling technology platform (called “microfluidics”) that increases the availability of diverse PET probes by reducing the cost and complexity of their production. Based on preliminary experiments showing that microfluidic chips can synthesis such compounds, we aimed to advance this technology to improve its robustness, increase its flexibility for a broad range of probes, and increase its user-friendliness. Through the research activities of this project, numerous advances were made; Tools were developed to enable the visualization of radioactive materials within microfluidic chips; Fundamental advances were made in the microfluidic chip architecture and fabrication process to increase its robustness and reliability; The microfluidic chip technology was shown to produce useful quantities of an example PET probes, and methods to further increase the output were successfully pursued; A “universal” chip was developed that could produce multiple types of PET probes, enabling the possibility of “on demand” synthesis of different probes; and Operation of the chip was automated to ensure minimal radiation exposure to the operator Based on the demonstrations of promising technical feasibility and performance, the microfluidic chip technology is currently being commercialized. It is anticipated that costs of microfluidic chips can be

  7. Efficacy of 10% whole Azadirachta indica (neem) chip as an adjunct to scaling and root planning in chronic periodontitis: A clinical and microbiological study

    OpenAIRE

    K Vennila; Elanchezhiyan, S.; Sugumari Ilavarasu

    2016-01-01

    Introduction: Anti-microbial therapy is essential along with conventional therapy in the management of periodontal disease. Instead of systemic chemical agents, herbal products could be used as antimicrobial agents. Herbal local drug delivery systems are effective alternative for systemic therapy in managing the chronic periodontal disease. In this study, 10% neem oil chip was used as a local drug delivery system to evaluate the efficacy in the periodontal disease management. Materials an...

  8. Transport of particles in liquid foams: a multi-scale approach; Etude multi-echelles du transport de particules dans les mousses liquides

    Energy Technology Data Exchange (ETDEWEB)

    Louvet, N.

    2009-11-15

    Foam is used for the decontamination of radioactive tanks since foam is a system that has a large surface for a low amount of liquid and as a consequence requires less water to be decontaminated. We study experimentally different particle transport configurations in fluid micro-channels network (Plateau borders) of aqueous foam. At first, foam permeability is measured at the scale of a single channel and of the whole foam network for 2 soap solutions known for their significant different interface mobility. Experimental data are well described by a model that takes into account the real geometry of the foam and by considering a constant value of the Boussinesq number of each soap solutions. Secondly, the velocity of one particle convected in a single foam channel is measured for different particle/channel aspect ratio. For small aspect ratio, a counterflow that is taking place at the channel's corners slows down the particle. A recirculation model in the channel foam films is developed to describe this effect. To do this, the Gibbs elasticity is introduced. Then, the threshold between trapped and released of one particle in liquid foam are carried out. This threshold is deduced from hydrodynamic and capillary forces equilibrium. Finally, the case of a clog foam node is addressed. (author)

  9. The scaled-charge additive force field for amino acid based ionic liquids

    DEFF Research Database (Denmark)

    Fileti, E. E.; Chaban, V. V.

    2014-01-01

    Ionic liquids (ILs) constitute an emerging research field. New ILs involve more and more organic and inorganic ions. Amino acid based ILs (AAILs) represent a specific interest due to their evolutional connection to proteins. We report a new non-polarizable force field (FF) for the eight AAILs...

  10. Drop on demand in a microfluidic chip

    International Nuclear Information System (INIS)

    In this work, we introduce the novel technique of in-chip drop on demand, which consists in dispensing picoliter to nanoliter drops on demand directly in the liquid-filled channels of a polymer microfluidic chip, at frequencies up to 2.5 kHz and with precise volume control. The technique involves a PDMS chip with one or several microliter-size chambers driven by piezoelectric actuators. Individual aqueous microdrops are dispensed from the chamber to a main transport channel filled with an immiscible fluid, in a process analogous to atmospheric drop on demand dispensing. In this paper, the drop formation process is characterized with respect to critical dispense parameters such as the shape and duration of the driving pulse, and the size of both the fluid chamber and the nozzle. Several features of the in-chip drop on demand technique with direct relevance to lab-on-a-chip applications are presented and discussed, such as the precise control of the dispensed volume, the ability to merge drops of different reagents and the ability to move a drop from the shooting area of one nozzle to another for multistep reactions. The possibility to drive the microfluidic chip with inexpensive audio electronics instead of research-grade equipment is also examined and verified. Finally, we show that the same piezoelectric technique can be used to generate a single gas bubble on demand in a microfluidic chip

  11. Scaling properties of the critical nucleus in classical and molecular-based theories of vapor-liquid nucleation

    International Nuclear Information System (INIS)

    Scaling relations are developed for the number g* of molecules in the critical nucleus and the nucleation barrier height W*. Density functional (DF) calculations for vapor-liquid nucleation confirm these relations and show systematic departure of the ratio W*/g*Δμ from its classical value of 1/2 with increasing difference Δμ in the chemical potential between the supersaturated vapor and bulk condensed phase. Discrepancies between classical and DF nucleation theories and between the classical theory and experiment are interpreted using these results. copyright 1996 The American Physical Society

  12. Feasibility of Storing Latent Heat with Liquid Crystals. Proof of Concept at Lab Scale

    Directory of Open Access Journals (Sweden)

    Rocío Bayón

    2016-04-01

    Full Text Available In this work, the first experimental results of thermotropic liquid crystals used as phase change materials for thermal storage are presented. For that purpose, the n = 10 derivative from the family of 4′-n-alkoxybiphenyl-4-carboxylic acids has been prepared. Different techniques like polarized-light microscopy, differential scanning calorimetry, thermogravimetric analysis and rheological measurements have been applied for its characterization. Having a mesophase/isotropic transition temperature around 251 °C, a clearing enthalpy of 55 kJ/kg, a thermal heat capacity of around 2.4 kJ/kg and a dynamic viscosity lower than 0.6 Pas, this compound fulfills the main requirements for being considered as latent heat storage material. Although further studies on thermal stability are necessary, the results already obtained are both promising and encouraging since they demonstrate de viability of this new application of liquid crystals as thermal storage media.

  13. Experimental study of electric breakdowns in liquid argon at centimeter scale

    CERN Document Server

    Blatter, A; Hsu, C -C; Janos, S; Kreslo, I; Luethi, M; von Rohr, C Rudolf; Schenk, M; Strauss, T; Weber, M S; Zeller, M

    2014-01-01

    In this paper we present results on measurements of the dielectric strength of liquid argon near its boiling point and cathode-anode distances in the range of 0.1 mm to 40 mm with spherical cathode and plane anode. We show that at such distances the applied electric field at which breakdowns occur is as low as 40 kV/cm. Flash-overs across the ribbed dielectric of the high voltage feed-through are observed for a length of 300 mm starting from a voltage of 55 kV. These results contribute to set reference for the breakdown-free design of ionization detectors, such as Liquid Argon Time Projection Chambers (LAr TPC).

  14. Theoretical coarse-graining approach to bridge length scales in diblock copolymer liquids

    OpenAIRE

    Sambriski, E. J.; Guenza, M. G.

    2007-01-01

    A microscopic theory for coarse graining diblock copolymers into dumbbells of interacting soft colloidal particles has been developed, based on the solution of liquid-state integral equations. The Ornstein-Zernike equation is solved to provide a mesoscopic description of the diblock copolymer system at the level of block centers of mass, and at the level of polymer centers of mass. Analytical forms of the total correlation functions for block-block, block-monomer, and center-of-mass pairs are...

  15. Universal logic gates via liquid-electronic hybrid divider

    KAUST Repository

    Zhou, Bingpu

    2012-01-01

    We demonstrated two-input microdroplet-based universal logic gates using a liquid-electronic hybrid divider. All 16 Boolean logic functions have been realized by manipulating the applied voltages. The novel platform consists of a microfluidic chip with integrated microdroplet detectors and external electronic components. The microdroplet detectors act as the communication media for fluidic and electronic information exchange. The presence or absence of microdroplets at the detector translates into the binary signal 1 or 0. The embedded micro-mechanical pneumatically actuated valve (PAV), fabricated using the well-developed multilayer soft lithography technique, offers biocompatibility, flexibility and accuracy for the on-chip realization of different logic functions. The microfluidic chip can be scaled up to construct large-scale microfluidic logic computation. On the other hand, the microfluidic chip with a specific logic function can be applied to droplet-based chemical reactions for on-demand bio or chemical analysis. Our experimental results have presented an autonomously driven, precision-controlled microfluidic chip for chemical reactions based on the IF logic function. © 2012 The Royal Society of Chemistry.

  16. Evaluation of Pressure Stable Chip-to-Tube Fittings Enabling High-Speed Chip-HPLC with Mass Spectrometric Detection.

    Science.gov (United States)

    Lotter, Carsten; Heiland, Josef J; Stein, Volkmar; Klimkait, Michael; Queisser, Marco; Belder, Detlev

    2016-08-01

    Appropriate chip-to-tube interfacing is an enabling technology for high-pressure and high-speed liquid chromatography on chip. For this purpose, various approaches, to connect pressure resistant glass chips with HPLC pumps working at pressures of up to 500 bar, were examined. Three side-port and one top-port connection approach were evaluated with regard to pressure stability and extra column band broadening. A clamp-based top-port approach enabled chip-HPLC-MS analysis of herbicides at the highest pressure and speed. PMID:27397738

  17. Optimizing in vitro large scale production of giant reed (Arundo donax L.) by liquid medium culture

    International Nuclear Information System (INIS)

    Tissue culture methods offer the potential for large-scale propagation of giant reed (Arundo donax L.), a promising crop for energy biomass. In previous trials, giant reed resulted particularly suitable to in vitro culture. In this paper, with the final goal of enhancing the efficiency of in vitro production process and reducing costs, the influence of four different culture media (agar or gellan-gum solidified medium, liquid medium into a temporary immersion system-RITA®or in a stationary state) on in vitro shoot proliferation of giant reed was evaluated. Giant reed exhibited a particular sensitivity to gelling agents during the phase of secondary shoot formation. Gellan gum, as compared to agar, improved the efficiency of in vitro culture giving more shoots with higher mean fresh and dry weight. Moreover, the cultivation of this species into a liquid medium under temporary immersion conditions or in a stationary state, was comparatively as effective as and cheaper than that into a gellan gum medium. Increasing 6-benzylaminopurine (BA) up to 4 mg l−1 also resulted in a further enhancement of secondary shoot proliferation. The good adaptability of this species to liquid medium and the high multiplication rates observed indicate the possibility to obtain from a single node at least 1200 plantlets every six multiplication cycles (about 6 months), a number 100 fold higher than that obtained yearly per plant by the conventional methods of vegetative multiplication. In open field, micropropagated plantlets guaranteed a higher number of survived plants, secondary stems and above ground biomass as compared to rhizome ones. - Highlights: • In vitro propagation offers the potential for large-scale propagation of giant reed. • The success of an in vitro protocol depends on the rate and mode of shoot proliferation. • Substituting liquid media to solid ones may decrease propagation costs in Arundo donax. • Giant reed showed good proliferation rates in

  18. Use of pilot plant scale continuous fryer to simulate industrial production of potato chips: thermal properties of palm olein blends under continuous frying conditions

    OpenAIRE

    Tarmizi, Azmil Haizam Ahmad; Ismail, Razali

    2013-01-01

    Binary blends of palm olein (PO) with sunflower oil (SFO), canola oil (CNO), and cottonseed oil (CSO) were formulated to assess their stability under continuous frying conditions. The results were then compared with those obtained in PO. The oil blends studied were: (1) 60:40 for PO + SFO; (2) 70:30 for PO + CNO; and (3) 50:50 for PO + CSO. The PO and its blends were used to fry potato chips at 180°C for a total of 56 h of operation. The evolution of analytical parameters such as tocols, indu...

  19. Results of 1/4-Scale Experiments. Vapor Simulant And Liquid Jet A Tests

    OpenAIRE

    Shepherd, Joseph E.; Krok, J. Chris; Julian J. Lee; Brown, Larry L.; Lynch, Robert T.; Samaras, Timothy M.; Birky, M. M.

    2000-01-01

    A quarter-scale engineering model of the center wing tank (CWT) of a 747-100 was constructed. This engineering model replicated the compartmentalization, passageways, and venting to the atmosphere. The model was designed to scale the fluid dynamical and combustion aspects of the explosion, not the structural failure of the beams or spars. The effect of structural failure on combustion was examined by using model beams and spars with deliberately engineered weak connections to the main tank st...

  20. Status of ArDM-1t: First observations from operation with a full ton-scale liquid argon target

    CERN Document Server

    Calvo, J; Daniel, M; Degunda, U; Di Luise, S; Epprecht, L; Gendotti, A; Horikawa, S; Knecht, L; Montes, B; Mu, W; Munoz, M; Murphy, S; Natterer, G; Nguyen, K; Nikolics, K; Periale, L; Regenfus, C; Romero, L; Rubbia, A; Santorelli, R; Sergiampietri, F; Sgalaberna, D; Viant, T; Wu, S

    2015-01-01

    ArDM-1t is the first operating ton-scale liquid argon detector for direct search of Dark Matter particles. Developed at CERN as Recognized Experiment RE18, the experiment has been approved in 2010 to be installed in the Spanish underground site LSC (Laboratorio Subterraneo de Canfranc). Under the label of LSC EXP-08-2010 the ArDM detector underwent an intensive period of technical completion and safety approval until the recent filling of the target vessel with almost 2 ton of liquid argon. This report describes the experimental achievements during commissioning of ArDM and the transition into a stage of first physics data taking in single phase operational mode. We present preliminary observations from this run. A first indication for the background discrimination power of LAr detectors at the ton-scale is shown. We present an outlook for completing the detector with the electric drift field and upgrade of the scintillation light readout system with novel detector modules based on SiPMs in order to improve t...

  1. Micromachined, planar-geometry, atmospheric-pressure, battery-operated microplasma devices (MPDs) on chips for analysis of microsamples of liquids, solids, or gases by optical-emission spectrometry.

    Science.gov (United States)

    Karanassios, Vassili; Johnson, Kara; Smith, Andrea T

    2007-08-01

    Because of their desirable characteristics, for example small size, lightness, low power and gas consumption, and potential for portability, miniaturized plasma sources are receiving significant attention in the scientific literature. To take advantage of these characteristics we micromachined and fabricated new, planar-geometry, self-igniting, atmospheric-pressure microplasma devices (MPDs) on chips. These microplasmas required such low power for their operation they could be operated from a re-chargeable battery (of the type used in cordless power-tools). Despite their advantages, most miniaturized plasma sources reported in the literature have not performed well with liquid samples; analysis of powders or solids that can be converted to a powder (and processed and used as slurries) is even more difficult. To address these shortcomings we coupled an electrothermal, mini-in-torch vaporization (mini-ITV) "dry" sample-introduction system to the low-power planar microplasma devices we developed. In this preliminary investigation, absolute detection limits obtained from microsamples of single-element liquid standards and optical emission spectrometry with photomultiplier-tube detection and a spectral bandpass similar to that of portable, commercially available fiber-optic spectrometers were in the low-pg to ng range, for example 2 pg (for K) to 25 ng (for Pb). Mini-ITV also enabled (as far as we are aware, for the first time) measurement of analyte emission from microsamples of powdered solids (as slurries). In addition to the 3% H2 in Ar mixtures, the ac-operated microplasmas were sustained by use of a variety of electrode materials and different plasma-support gases (e.g. Ar, He and 3% H2 in He) thus indicating fabrication versatility and operational flexibility. Such flexibility has the potential to enable microplasmas to be tailored to analytical problems, and this is demonstrated by using a He MPD and chlorine emission measurements (837.594 nm) from gaseous

  2. Free surface transition and momentum augmentation of liquid flow in Micro/Nano-scale channels with hydrophobic and hydrophilic surfaces

    International Nuclear Information System (INIS)

    We propose a novel micro/nano-scale nozzle structure, featuring an interfacial line between the hydrophilic and the hydrophobic surfaces for a jetting system, such as an inkjet head or electrospray devices. This research will investigate the impact of the interfacial line on flow instability and momentum augmentation as the liquid meniscus moves across the line. The research methods used in this paper, in respect to micro-and nano-scale channels, are computational fluid dynamics (CFD) and non-equilibrium molecular dynamics (MD), respectively. With the growing interest in micro/ nano electromechanical systems (MEMS/NEMS), many studies have been conducted to develop an advanced micro/ nanofluidic system. However, until now, there have been few in-depth studies on passive flow control in micro and nano nozzles using the hydrophilic and hydrophobic surface characteristics. In this research, the sequential arrangement of hydrophilic and hydrophobic surfaces in the nozzle is presented along with an investigation into how flow instability and momentum augmentation are going to be applied to an efficient micro/nano jetting system. When a liquid meniscus arrives at the interfacial line between hydrophilic and hydrophobic surfaces, the meniscus shape changes from concave to convex and the fluid motion near the wall stops until the concave shape is fully converted. Because the momentum should be conserved, the lost momentum near the wall transfers to the center region, and therefore the liquid at the center region is accelerated as it crosses the line. If we use this nozzle structure and the augmentation of the momentum near the center, a tiny droplet can be easily generated

  3. Towards Liquid Chromatography Time-Scale Peptide Sequencing and Characterization of Post-Translational Modifications in the Negative-Ion Mode Using Electron Detachment Dissociation Tandem Mass Spectrometry

    DEFF Research Database (Denmark)

    Kjeldsen, Frank; Hørning, Ole B; Jensen, Søren S;

    2008-01-01

    in large-scale peptide characterization strategies. We successfully increased the EDD fragmentation efficiency (up to 9%), and demonstrate for the first time the utility of EDD-MS/MS in liquid chromatography time-scale experiments. Peptides and phosphopeptides were analyzed in both positive- and negative...

  4. A primary battery-on-a-chip using monolayer graphene

    Science.gov (United States)

    Iost, Rodrigo M.; Crespilho, Frank N.; Kern, Klaus; Balasubramanian, Kannan

    2016-07-01

    We present here a bottom-up approach for realizing on-chip on-demand batteries starting out with chemical vapor deposition-grown graphene. Single graphene monolayers contacted by electrode lines on a silicon chip serve as electrodes. The anode and cathode are realized by electrodeposition of zinc and copper respectively onto graphene, leading to the realization of a miniature graphene-based Daniell cell on a chip. The electrolyte is housed partly in a gel and partly in liquid form in an on-chip enclosure molded using a 3d printer or made out of poly(dimethylsiloxane). The realized batteries provide a stable voltage (∼1.1 V) for many hours and exhibit capacities as high as 15 μAh, providing enough power to operate a pocket calculator. The realized batteries show promise for deployment as on-chip power sources for autonomous systems in lab-on-a-chip or biomedical applications.

  5. Techno-economic analysis for incorporating a liquid-liquid extraction system to remove acetic acid into a proposed commercial scale biorefinery.

    Science.gov (United States)

    Aghazadeh, Mahdieh; Engelberth, Abigail S

    2016-07-01

    Mitigating the effect of fermentation inhibitors in bioethanol plants can have a great positive impact on the economy of this industry. Liquid-liquid extraction (LLE) using ethyl acetate is able to remove fermentation inhibitors-chiefly, acetic acid-from an aqueous solution used to produce bioethanol. The fermentation broth resulting from LLE has higher performance for ethanol yield and its production rate. Previous techno-economic analyses focused on second-generation biofuel production did not address the impact of removing the fermentation inhibitors on the economic performance of the biorefinery. A comprehensive analysis of applying a separation system to mitigate the fermentation inhibition effect and to provide an analysis on the economic impact of removal of acetic acid from corn stover hydrolysate on the overall revenue of the biorefinery is necessary. This study examines the pros and cons associated with implementing LLE column along with the solvent recovery system into a commercial scale bioethanol plant. Using details from the NREL-developed model of corn stover biorefinery, the capital costs associated with the equipment and the operating cost for the use of solvent were estimated and the results were compared with the profit gain due to higher ethanol production. Results indicate that the additional capital will add 1% to the total capital and manufacturing cost will increase by 5.9%. The benefit arises from the higher ethanol production rate and yield as a consequence of inhibitor extraction and results in a $0.35 per gallon reduction in the minimum ethanol selling price (MESP). © 2016 American Institute of Chemical Engineers Biotechnol. Prog., 32:971-977, 2016. PMID:27390294

  6. Pixel detector readout chip

    CERN Multimedia

    1991-01-01

    Close-up of a pixel detector readout chip. The photograph shows an aera of 1 mm x 2 mm containing 12 separate readout channels. The entire chip contains 1000 readout channels (around 80 000 transistors) covering a sensitive area of 8 mm x 5 mm. The chip has been mounted on a silicon detector to detect high energy particles.

  7. Performance analysis of an innovative small-scale trigeneration plant with liquid desiccant cooling system

    Energy Technology Data Exchange (ETDEWEB)

    Badami, M.; Portoraro, A. [Dipartimento di Energetica, Politecnico di Torino, C.so Duca degli Abruzzi 24, Torino (Italy)

    2009-11-15

    The paper deals with an innovative natural gas combined heat, cooling and power (CHCP) system with electrical, heating and cooling capacities of 126/220/210 kW, respectively. The trigeneration plant is composed of a cogenerator which uses an automotive derived gas fired internal combustion engine (ICE), coupled to a liquid LiCl-water desiccant cooling system which recovers heat from the flue gases and from the ICE cooling water. The paper describes the energetic and economic analyses of the plant and it makes some evaluations of the effects of fuel and electric prices and of the subsides and plant costs on the economic indices of the system. (author)

  8. Separation of Cs from high level liquid radioactive waste on the engineering scale

    International Nuclear Information System (INIS)

    137Cs is an established isotope for use as a radiation source. The major source of 137Cs is high level liquid radioactive waste (HLW). Ammonium molybdophosphate (AMP) has been widely studied for separation of Cs. Since AMP is microcrystalline in nature, its blending with asbestos is necessary to obtain packed column characteristics. A column made of SS has been fabricated and packed with AMP. The flow characteristics, capacity, regeneration and reuse aspects have been studied in detail with the help of simulated HLW. (author). 4 refs., 3 tabs

  9. Evaluation of the portable liquid scintillation counter Triathler™ for characterising small-scale nuclear incidents

    International Nuclear Information System (INIS)

    The portable liquid scintillation counter Triathler™ was used under laboratory conditions to perform gross alpha and beta measurements as well as wipe tests. The results of these measurements were compared with results from certified methods that are routinely used at our laboratory. Background measurements with different scintillation cocktails using different counting modes were performed and the occurrence of luminescence after sample preparation in the lower energy regions was evaluated. An increased background was observed shortly after the mixing of the distilled water and the scintillation cocktail. The scintillation cocktail Hisafe 3 proved to be most suitable for on-site applications with the Triathler. (author)

  10. A scaling method for combustion stability rating of coaxial gas liquid injectors in a subscale chamber

    International Nuclear Information System (INIS)

    A scaling method to examine combustion stability characteristics of a coaxial injector is devised based on the acoustics and combustion dynamics in a chamber. The method is required for a subscale test of stability rating with a model chamber, which is cost effective compared with an actual full scale test. First, scaling and similarity rules are considered for stability rating and thereby, three conditions of acoustic, hydrodynamic, and flame condition similarities are proposed. That is, for acoustic similarity, the natural or resonant frequencies in the actual chamber should be maintained in the model chamber. And, two parameters of density ratio and velocity ratio are derived for the requirement of hydrodynamic and flame condition similarities between the actual and the model conditions. Next, one example of an actual combustion chamber with high performance is selected and the proposed scaling method is applied to the chamber for understanding of the method. The design operating condition for a model test is presented by mass flow rates of propellants. Stability boundaries can be identified on the coordinate plane of chamber pressure and mixture ratio of fuel and oxidizer by applying the scaling method

  11. Electro/Magnetically Induced Controllable Rotation In Small-scale Liquid Flow

    CERN Document Server

    Amjadi, A; Sobhani, S O; Shirsavar, R

    2013-01-01

    We study all the possibilities of producing rotating flow in an incompressible fluid by electric and magnetic fields. We start with a general theoretical basis and look for different configurations and set-ups which electric/magnetic field and an electric current affect the vorticity of fluid resulting in rotation on liquid flow. We assume steady-state conditions and time-independent electric and magnetic fields as the external body torque. Regarding the theoretical basis, we propose three experimental set-ups in which by applying fields on a fluid, rotational vortices are produced: (a) a uniform electric field and a uniform electric current, (b) a uniform electric current and a non-uniform magnetic field, and (c) a non-uniform electric current and a uniform magnetic field. The first case has been reported in detail named "Liquid Film Motor". The two other cases are experimentally investigated here for a cubic an cylindrical cells. The rotational velocity patterns are obtained by PIV technique, and the result...

  12. Universal scaling between structural relaxation and vibrational dynamics in glass-forming liquids and polymers

    Science.gov (United States)

    Larini, L.; Ottochian, A.; de Michele, C.; Leporini, D.

    2008-01-01

    If liquids, polymers, bio-materials, metals and molten salts can avoid crystallization during cooling or compression, they freeze into a microscopically disordered solid-like state, a glass. On approaching the glass transition, particles become trapped in transient cages-in which they rattle on picosecond timescales-formed by their nearest neighbours; the particles spend increasing amounts of time in their cages as the average escape time, or structural relaxation time τα, increases from a few picoseconds to thousands of seconds through the transition. Owing to the huge difference between relaxation and vibrational timescales, theoretical studies addressing the underlying rattling process have challenged our understanding of the structural relaxation. Numerical and experimental studies on liquids and glasses support the theories, but not without controversies (for a review see ref. 21). Here we show computer simulations that, when compared with experiments, reveal the universal correlation of the structural relaxation time (as well as the viscosity η) and the rattling amplitude from glassy to low-viscosity states. According to the emerging picture the glass softens when the rattling amplitude exceeds a critical value, in agreement with the Lindemann criterion for the melting of crystalline solids and the free-volume model.

  13. Pilot-scale synthesis of metal nanoparticles by high-speed pulsed laser ablation in liquids

    Science.gov (United States)

    Streubel, René; Bendt, Georg; Gökce, Bilal

    2016-05-01

    The synthesis of catalysis-relevant nanoparticles such as platinum and gold is demonstrated with productivities of 4 g h‑1 for pulsed laser ablation in liquids (PLAL). The major drawback of low productivity of PLAL is overcome by utilizing a novel ultrafast high-repetition rate laser system combined with a polygon scanner that reaches scanning speeds up to 500 m s‑1. This high scanning speed is exploited to spatially bypass the laser-induced cavitation bubbles at MHz-repetition rates resulting in an increase of the applicable, ablation-effective, repetition rate for PLAL by two orders of magnitude. The particle size, morphology and oxidation state of fully automated synthesized colloids are analyzed while the ablation mechanisms are studied for different laser fluences, repetition rates, interpulse distances, ablation times, volumetric flow rates and focus positions. It is found that at high scanning speeds and high repetition rate PLAL the ablation process is stable in crystallite size and decoupled from shielding and liquid effects that conventionally occur during low-speed PLAL.

  14. E-SCAPE: A scale facility for liquid-metal, pool-type reactor thermal hydraulic investigations

    International Nuclear Information System (INIS)

    Highlights: • The E-SCAPE facility is a thermal hydraulic scale model of the MYRRHA fast reactor. • The focus is on mixing and stratification in liquid-metal pool-type reactors. • Forced convection, natural convection and the transition are investigated. • Extensive instrumentation allows validation of computational models. • System thermal hydraulic and CFD models have been used for facility design. - Abstract: MYRRHA (Multi-purpose hYbrid Research Reactor for High-tech Applications) is a flexible fast-spectrum research reactor under design at SCK·CEN. MYRRHA is a pool-type reactor with lead bismuth eutectic (LBE) as primary coolant. The proper understanding of the thermal hydraulic phenomena occurring in the reactor pool is an important issue in the design and licensing of the MYRRHA system and liquid-metal cooled reactors by extension. Model experiments are necessary for understanding the physics, for validating experimental tools and to qualify the design for the licensing. The E-SCAPE (European SCAled Pool Experiment) facility at SCK·CEN is a thermal hydraulic 1/6-scale model of the MYRRHA reactor, with an electrical core simulator, cooled by LBE. It provides experimental feedback to the designers on the forced and natural circulation flow patterns. Moreover, it enables to validate the computational methods for their use with LBE. The paper will elaborate on the design of the E-SCAPE facility and its main parameters. Also the experimental matrix and the pre-test analysis using computational fluid dynamics (CFD) and system thermal hydraulics codes will be described

  15. E-SCAPE: A scale facility for liquid-metal, pool-type reactor thermal hydraulic investigations

    Energy Technology Data Exchange (ETDEWEB)

    Van Tichelen, Katrien, E-mail: kvtichel@sckcen.be [SCK-CEN, Boeretang 200, 2400 Mol (Belgium); Mirelli, Fabio, E-mail: fmirelli@sckcen.be [SCK-CEN, Boeretang 200, 2400 Mol (Belgium); Greco, Matteo, E-mail: mgreco@sckcen.be [SCK-CEN, Boeretang 200, 2400 Mol (Belgium); Viviani, Giorgia, E-mail: giorgiaviviani@gmail.com [University of Pisa, Lungarno Pacinotti 43, 56126 Pisa (Italy)

    2015-08-15

    Highlights: • The E-SCAPE facility is a thermal hydraulic scale model of the MYRRHA fast reactor. • The focus is on mixing and stratification in liquid-metal pool-type reactors. • Forced convection, natural convection and the transition are investigated. • Extensive instrumentation allows validation of computational models. • System thermal hydraulic and CFD models have been used for facility design. - Abstract: MYRRHA (Multi-purpose hYbrid Research Reactor for High-tech Applications) is a flexible fast-spectrum research reactor under design at SCK·CEN. MYRRHA is a pool-type reactor with lead bismuth eutectic (LBE) as primary coolant. The proper understanding of the thermal hydraulic phenomena occurring in the reactor pool is an important issue in the design and licensing of the MYRRHA system and liquid-metal cooled reactors by extension. Model experiments are necessary for understanding the physics, for validating experimental tools and to qualify the design for the licensing. The E-SCAPE (European SCAled Pool Experiment) facility at SCK·CEN is a thermal hydraulic 1/6-scale model of the MYRRHA reactor, with an electrical core simulator, cooled by LBE. It provides experimental feedback to the designers on the forced and natural circulation flow patterns. Moreover, it enables to validate the computational methods for their use with LBE. The paper will elaborate on the design of the E-SCAPE facility and its main parameters. Also the experimental matrix and the pre-test analysis using computational fluid dynamics (CFD) and system thermal hydraulics codes will be described.

  16. Microfluidic-integrated laser-controlled microactuators with on-chip microscopy imaging functionality.

    Science.gov (United States)

    Jung, Jae Hee; Han, Chao; Lee, Seung Ah; Kim, Jinho; Yang, Changhuei

    2014-10-01

    The fabrication of a novel microfluidic system, integrated with a set of laser-controlled microactuators on an ePetri on-chip microscopy platform, is presented in this paper. In the fully integrated microfluidic system, a set of novel thermally actuated paraffin-based microactuators, precisely controlled by programmed laser optics, was developed to regulate flow and to provide pumping of liquid solutions without external connections. The microfluidic chip was fabricated on a complementary metal-oxide-semiconductor (CMOS)-imaging sensor chip on an ePetri platform; this configuration provided real-time, wide field-of-view, high-resolution imaging using a sub-pixel sweeping microscopy technique. The system of microactuators, which consisted of microvalves and a micropump, operated well in the microfluidic channel with a focused near-infrared laser beam providing the actuation control. As a demonstration, we used our prototype to assess cell-drug interactions and to monitor cell growth directly within an incubator in real time. The powerful combination of laser-actuated microfluidics and chip-scale microscopy techniques represents a significant step forward in terms of a simple, robust, high-throughput, and highly compact analysis system for biomedical and bioscience applications. PMID:25099225

  17. Scaling Laws for liquid and ion transport in nanochannels grafted with polyelectrolyte brushes

    Science.gov (United States)

    Chen, Guang; Sinha, Shayandev; Das, Siddhartha; Soft Matter, Interfaces,; Energy Laboratory (Smiel) Team

    Grafting nanochannels with polyelectrolyte (PE) brushes renders tremendous functionality to the nanochannels, making them capable of applications such as ion manipulation, ion sensing, current rectification, nanofluidic diode fabrication, and flow control. PE brush is a special case of polymers at interfaces; such brush-like structure is possible only when the grafting density (σ) is beyond a critical value. In this study, we shall propose scaling laws that identify σ-N(N is the size of the PE molecule) combination that simultaneously ensure that the grafted PE molecules adopt ''brush''-like configuration and the height of the PE brushes are smaller than the nanochannel half height. Secondly, we pinpoint the scaling conditions where the electrostatic effects associated with the PE brushes can be decoupled from the corresponding PE excluded volume and elastic effects; such de-coupling has tremendous connotation in context of modeling of electrostatics and transport at PE-brush-covered interfaces. Thirdly, we provide scaling arguments to quantify the dependence of the flow penetration depth into the PE brush as a function of the σ-N combination. Finally, our scaling estimates pinpoint the conditions where the flow or electric field induced deformation of the grafted nanochannel PE brushes can be neglected while modeling the pressure-driven or electroosmotic transport or ionic current in such nanochannels.

  18. Copper recovery in a bench-scale carrier facilitated tubular supported liquid membrane system

    Directory of Open Access Journals (Sweden)

    Makaka S.

    2010-01-01

    Full Text Available The extraction of copper ions in a tubular supported liquid membrane using LIX 984NC as a mobile carrier was studied, evaluating the effect of the feed characteristics (flowrate, density, viscosity on the feedside laminar layer of the membrane. A vertical countercurrent, double pipe perspex benchscale reactor consisting of a single hydrophobic PVDF tubular membrane mounted inside was used in all test work. The membrane was impregnated with LIX 984NC and became the support for this organic transport medium. Dilute Copper solution passed through the centre pipe and sulphuric acid as strippant passed through the shell side. Copper was successfully transported from the feedside to the stripside and from the data obtained, a relationship between Schmidt, Reynolds and Sherwood number was achieved of.

  19. Clean coal technology: commercial-scale demonstration of the liquid phase methanol (LPMEOH{trademark}) process

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-04-01

    The report discusses the demonstration of Air Products and Chemical, Inc.`s Liquid Phase Methanol (LPMEOTH {trademark}) Process which is designed to convert synthesis gas derived from the gasification of coal into methanol for use as a chemical intermediate or as a low-sulfur dioxide and low-nitrogen oxides emitting alternative fuel. The project was selected for funding by the US Clean Coal Technology Program Round III in 1992. Construction of the Demonstration Project at Eastman Chemical Co`s Kingsport complex began in October 1995 and was completed in January 1997. Production rates of over 300 tons per day of methanol have been achieved and availability for the unit has exceeded 96% since startup. The LPMEOH{trademark} Process can enhance integrated gasification combined cycle (IGCC) power generation by converting part of the syngas from the gasifier to methanol which can be solid or used as a peak-sharing fuel. 50 refs., 5 figs., 7 photos.

  20. Full range determination of 222Rn at the watershed scale by liquid scintillation counting

    International Nuclear Information System (INIS)

    222Rn has been increasingly used to identify groundwater contribution to surface water. Particular attention has been paid to analytical protocols and counting parameters used for liquid alpha scintillation measurements over a range of activities covering river and groundwater domains. Direct measurements and Rn-extraction protocols are optimized, and scintillometer efficiency is calibrated using international standards over the 0.5–35 Bq/L range. The interval of activities was performed in surface water and groundwater from a small Canadian watershed. - Highlights: ► Several analytical tests were developed to optimize protocols for 222Rn measurements in water. ► Two analytical procedures, direct and extraction methods were found in order to guarantee a 0.5–35 Bq/L range of measurement. ► A specific test has been conducted to evidence that both methods are well calibrated. ► Those protocols have been tested on water from a small Canadian watershed

  1. Liquid Methane Testing With a Large-Scale Spray Bar Thermodynamic Vent System

    Science.gov (United States)

    Hastings, L. J.; Bolshinskiy, L. G.; Hedayat, A.; Flachbart, R. H.; Sisco, J. D.; Schnell. A. R.

    2014-01-01

    NASA's Marshall Space Flight Center conducted liquid methane testing in November 2006 using the multipurpose hydrogen test bed outfitted with a spray bar thermodynamic vent system (TVS). The basic objective was to identify any unusual or unique thermodynamic characteristics associated with densified methane that should be considered in the design of space-based TVSs. Thirteen days of testing were performed with total tank heat loads ranging from 720 to 420 W at a fill level of approximately 90%. It was noted that as the fluid passed through the Joule-Thompson expansion, thermodynamic conditions consistent with the pervasive presence of metastability were indicated. This Technical Publication describes conditions that correspond with metastability and its detrimental effects on TVS performance. The observed conditions were primarily functions of methane densification and helium pressurization; therefore, assurance must be provided that metastable conditions have been circumvented in future applications of thermodynamic venting to in-space methane storage.

  2. Transient thermal analysis for radioactive liquid mixing operations in a large-scaled tank

    International Nuclear Information System (INIS)

    A transient heat balance model was developed to assess the impact of a Submersible Mixer Pump (SMP) on radioactive liquid temperature during the process of waste mixing and removal for the high-level radioactive materials stored in Savannah River Site (SRS) tanks. The model results will be mainly used to determine the SMP design impacts on the waste tank temperature during operations and to develop a specification for a new SMP design to replace existing longshaft mixer pumps used during waste removal. The present model was benchmarked against the test data obtained by the tank measurement to examine the quantitative thermal response of the tank and to establish the reference conditions of the operating variables under no SMP operation. The results showed that the model predictions agreed with the test data of the waste temperatures within about 10%

  3. Radioactivity concentration in liquid and solid phases of scale and sludge generated in the petroleum industry.

    Science.gov (United States)

    Paranhos Gazineu, Maria Helena; de Araújo, Andressa Arruda; Brandão, Yana Batista; Hazin, Clovis Abrahão; de O Godoy, José Marcos

    2005-01-01

    Scales and sludge generated during oil extraction and production can contain uranium, thorium, radium and other natural radionuclides, which can cause exposure of maintenance personnel. This work shows how the oil content can influence the results of measurements of radionuclide concentration in scale and sludge. Samples were taken from a PETROBRAS unit in Northeast Brazil. They were collected directly from the inner surface of water pipes or from barrels stored in the waste storage area of the E&P unit. The oil was separated from the solids with a Soxhlet extractor by using aguarras at 90+/-5 degrees C as solvent. Concentrations of 226Ra and 228Ra in the samples were determined before and after oil extraction by using an HPGe gamma spectrometric system. The results showed an increase in the radionuclide concentration in the solid (dry) phase, indicating that the above radionuclides concentrate mostly in the solid material. PMID:15748660

  4. Synthetically chemical-electrical mechanism for controlling large scale reversible deformation of liquid metal objects

    OpenAIRE

    Zhang, Jie; Sheng, Lei; Liu, Jing

    2014-01-01

    Reversible deformation of a machine holds enormous promise across many scientific areas ranging from mechanical engineering to applied physics. So far, such capabilities are still hard to achieve through conventional rigid materials or depending mainly on elastomeric materials, which however own rather limited performances and require complicated manipulations. Here, we show a basic strategy which is fundamentally different from the existing ones to realize large scale reversible deformation ...

  5. Redsharc: A Programming Model and On-Chip Network for Multi-Core Systems on a Programmable Chip

    OpenAIRE

    Kritikos, William V.; Andrew G. Schmidt; Ron Sass; Anderson, Erik K.; Matthew French

    2012-01-01

    The reconfigurable data-stream hardware software architecture (Redsharc) is a programming model and network-on-a-chip solution designed to scale to meet the performance needs of multi-core Systems on a programmable chip (MCSoPC). Redsharc uses an abstract API that allows programmers to develop systems of simultaneously executing kernels, in software and/or hardware, that communicate over a seamless interface. Redsharc incorporates two on-chip networks that directly implement the API to suppor...

  6. Commercial-Scale Demonstration of the Liquid Phase Methanol (LPMEOH(TM)) Process

    Energy Technology Data Exchange (ETDEWEB)

    None

    1997-06-30

    The Liquid Phase Methanol (LPMEOHTM) Demonstration Project at Kingsport, Tennessee, is a $213.7 million cooperative agreement between the U.S. Department of Energy (DOE) and Air Products Liquid Phase Conversion Company, L.P. (the Partnership). Air Products and Chemicals, Inc. (Air Products) and Eastman Chemical Company (Eastman) formed the Partnership to execute the Demonstration Project. The LPMEOIYM Process Demonstration Unit was built at a site located at the Eastman complex in Kingsport. During this quarter, comments from the DOE on the Topical Report "Economic Analysis - LPMEOHTM Process as an Add-on to IGCC for Coproduction" were received. A recommendation to continue with design verification testing for the coproduction of dimethyl ether (DIME) and methanol was made. DME design verification testing studies show the liquid phase DME (LPDME) process will have a significant economic advantage for the coproduction of DME for local markets. An LPDME catalyst system with reasonable long-term activity and stability is being developed. A recommendation document summarizing catalyst targets, experimental results, and the corresponding economics for a commercially successful LPDME catalyst was issued on 30 June 1997. The off-site, product-use test plan was updated in June of 1997. During this quarter, Acurex Environmental Corporation and Air Products screened proposals for this task by the likelihood of the projects to proceed and the timing for the initial methanol requirement. Eight sites from the list have met these criteria. The formal submission of the eight projects for review and concurrence by the DOE will be made during the next reporting period. The site paving and final painting were completed in May of 1997. Start-up activities were completed during the reporting period, and the initial methanol production from the demonstration unit occurred on 02 April 1997. The first extended stable operation at the nameplate capacity of 80,000 gallons per day (260 tons

  7. Molecular Dynamics Simulation of Microstructure Transitions in a Large-Scale Liquid Metal A1 System During Rapid Cooling Processes

    Institute of Scientific and Technical Information of China (English)

    刘让苏; 董科军; 李基永; 余艾冰; 邹瑞萍

    2002-01-01

    We perform a molecular dynamics simulation of microstructure transitions in a large-scale system consisting of 400000 atoms of liquid metal Al by the Clare supercomputer. A cluster-type index method is proposed to describe the structures of various short-range-order clusters in the liquid system. It is demonstrated that the icosahedron cluster (12 0 12 0) plays the most important role in the microstructure transition and that some larger clusters (containing more than 130 atoms) are formed in the system during the rapid cooling processes. It is obvious that the larger clusters are formed by means of combining some middle clusters, and that the middle clusters are formed with several smaller clusters. However, the larger clusters are not formed to be the multi-shell configuration as shown in the mass spectrum analysis of the cluster configurations of A1 obtained by gaseous deposition, ionic spray methods and so on. This result can be used to explain the essential distinction between the cluster configurations of Al formed in two different ways.

  8. The uncertainty analysis on energy scale due to the variation of W value for liquid xenon dark matter detector

    Science.gov (United States)

    Wang, Lu; Mei, Dongming; Cubed Collaboration

    2016-03-01

    The average energy expended per electron-ion pair, W value, is critical in understanding a liquid xenon detector energy response to low energy recoils. The reduction of scintillation and ionization yield for electronic recoils and nuclear recoils are explained using the scintillation quenching mechanism due to the variation of the average energy expended per electron hole pair, W value, which includes the energy lost to scintillation and phonon generation. We show the theoretical calculation of scintillation efficiency with W value in comparison with experimental data. The impact of variation of W value on the analysis of energy scale is discussed in detail. We conclude that the W value determined with experimental data depends on recoil energy and particle type. This work is supported by NSF in part by the NSF OIA 1434142, DOE Grant DE-FG02-10ER46709, and the State of South Dakota.

  9. Measurements of liquid phase residence time distributions in a pilot-scale continuous leaching reactor using radiotracer technique

    International Nuclear Information System (INIS)

    An alkaline based continuous leaching process is commonly used for extraction of uranium from uranium ore. The reactor in which the leaching process is carried out is called a continuous leaching reactor (CLR) and is expected to behave as a continuously stirred tank reactor (CSTR) for the liquid phase. A pilot-scale CLR used in a Technology Demonstration Pilot Plant (TDPP) was designed, installed and operated; and thus needed to be tested for its hydrodynamic behavior. A radiotracer investigation was carried out in the CLR for measurement of residence time distribution (RTD) of liquid phase with specific objectives to characterize the flow behavior of the reactor and validate its design. Bromine-82 as ammonium bromide was used as a radiotracer and about 40–60 MBq activity was used in each run. The measured RTD curves were treated and mean residence times were determined and simulated using a tanks-in-series model. The result of simulation indicated no flow abnormality and the reactor behaved as an ideal CSTR for the range of the operating conditions used in the investigation. - Highlights: • Radiotracer technique was applied for evaluation of design of a pilot-scale continuous leaching reactor. • Mean residence time and dead volume were estimated. Dead volume was found to be ranging from 4% to 15% at different operating conditions. • Tank-in-series model was used to simulate the measured RTD data and was found suitable to describe the flow in the reactor. • No flow abnormality was found and the reactor behaved as a well-mixed system. The design of the reactor was validated

  10. Assessment of survivability of liquid water and organic materials through modeling of large-scale impacts

    Science.gov (United States)

    Blank, Jennifer

    Comets, estimated to contain up to 25 wt.% organic material as both ices and more complex, refractory compounds, have been proposed as a vehicle for the delivery of organic compounds to the early Earth and other rocky planets. Successful delivery requires that some of the organic materials survive the extreme temperatures associated with impact, but the response of organic compounds to impact (shock) processing under these conditions is unknown. Several researchers have explored organic-delivery scenarios computationally and experimentally. Here, I will summarize work that addresses the issue of impact delivery and focus on current efforts to track the phase-state of water during a modeled comet-earth collision over a range of impact angles. On the basis of model results generated using a three-dimensional shock physics code (GEODYN), I will infer survivability of organic compounds and liquid water in a range of impact scenarios for comet-Earth and asteroid-Earth collisions. These results will be described in the context of the flux of astromaterials, and organic matter in particular, to young planets.

  11. A Nuclear Magnetic Resonance Force Microscope for Micron-scale Liquids

    Science.gov (United States)

    Giraldo, Felipe; Paster, Jeremy W.; Tennant, Daniel M.; Markert, John T.

    2015-03-01

    We have designed and constructed a Nuclear Magnetic Resonance Force Microscopy (NMRFM) probe for the analysis of liquid and soft matter samples. This NRMFM probe uses a magnet-on-cantilever geometry and is equipped with dual x- y- z piezoelectric motion stages, for micron-step coarse positioning and sub-nanometer fine positioning of both the laser interferometer and the sample with respect to the cantilever, permitting three-dimensional scanning-mode detection of nuclear magnetism. The probe keeps the cantilever detector in high vacuum, maintaining a high Q, while the local NMR properties of nearby aqueous samples in glass microtubes are measured. The entire probe head fits in either a 3.5-cm bore magnet or in an electromagnet with a similarly small gap. We plan to demonstrate the ability to scan and distinguish microscale NMR properties using a copper sulfate solution with concentrations in the 2-20 millimolar range, thus providing dynamical imaging of regions with differing longitudinal relaxation times, T1. This concentration range will permit us to compare the conventional saturation-recovery pulse sequence with a more efficient single-pulse detection, possible when T1 is comparable to or less than the duration of the modified cyclic-adiabatic-inversion pulse.

  12. The dynamics of azulene in liquids and compressed gases on ultrafast time scales

    International Nuclear Information System (INIS)

    The ultrafast dynamics of vibrationally hot ground state azulene molecules have been time resolved by picosecond transient absorption spectroscopy in a variety of solvents including hexane, chloromethanes, methanol, CClF3, Xe and Kr. A high pressure optical cell was used to liquify gases for use as solvents and change their density and temperature, independently, over the entire liquid density range. Experimental results indicate that the vibrational cooling rate is strongly solvent dependent, with cooling rates of approximately 20 psec in molecular solvents and approximately 150 psec in atomic solvents. Comparison of the rates in Xe and Kr at constant density demonstrates the strong effect of solvent mass on energy transfer. The effect of solvent temperature on vibrational cooling is minimal, as is the effect of solvent density. This latter result is quite surprising in light of earlier experiments on simpler molecular systems, such as I2 in Xe. This anomalous density effect is examined in light of Isolated Binary Collision (IBC) theory and bulk thermal transport models. Both theories accurately model all experimental results obtained with the exception of the density effect. Possible explanations for the breakdown of IBC theory in this case are offered along with methods to improve IBC theory for application to complex three dimensional molecular systems

  13. Dynamic cross-flow filtration: enhanced continuous small-scale solid-liquid separation.

    Science.gov (United States)

    Gursch, Johannes; Hohl, Roland; Dujmovic, Diana; Brozio, Jörg; Krumme, Markus; Rasenack, Norbert; Khinast, Johannes

    2016-06-01

    In a previous study, a small-scale dynamic filtration device (SFD) was analyzed and the basic mechanisms governing the filtration process were characterized. The present work aims at improving the device's performance in terms of actual production. Various operation modes were tested in order to increase permeate flow and concentration factors (CF), while maintaining a fully continuous production mode. Both, a vacuum-enhanced and a pulsating operation mode, proved to be superior to the currently implemented open-operation mode. For example, for lactose, an increase of the CF could be achieved from 1.7 in open mode to 7.6 in pulsating operation mode. The investigated operation strategy enables process control systems to rapidly react to fluctuating feeds that may occur due to changes in upstream manufacturing steps. As a result, not only filtration performance in terms of permeate rate but also process flexibility can be significantly increased. Overall, vacuum-enhanced operation was shown to be most promising for integration into an industrial environment. The option to elevate achievable concentration factors, ease of flow monitoring as well as the ability to react to changes in the feed conditions allow for effective and efficient continuous small-scale filtration. PMID:26489453

  14. Commercial-Scale Demonstration of the Liquid Phase Methanol (LPMEOH) Process

    Energy Technology Data Exchange (ETDEWEB)

    None

    1998-12-21

    he Liquid Phase Methanol (LPMEOW) Demonstration Project at Kingsport Tennessee, is a $213.7 million cooperative agreement between the U.S. Department of Energy (DOE) and Air Products Liquid Phase Conversion Company, L.P. (the Partnership) to produce methanol from coal-derived synthesis gas (syngas). Air Products and Chemicals, Inc. (Air Products) and Eastman Chemical Company (Eastman) formed the Partnership to execute the Demonstration Project. The LPMEOEP Process Demonstration Unit was built at a site located at the Eastman coal-to-chemicals complex in Kingsport. The LPMEOHW Demonstration Facility completed its first year of operation on 02 April 1998. The LPMEOW Demonstration Facility also completed the longest continuous operating run (65 days) on 21 April 1998. Catalyst activity, as defined by the ratio of the rate constant at any point in time to the rate constant for freshly reduced catalyst (as determined in the laboratory autoclave), was monitored throughout the reporting period. During a six-week test at a reactor temperature of 225oC and Balanced Gas flowrate of 700 KSCFH, the rate of decline in catalyst activity was steady at 0.29-0.36% per day. During a second one-month test at a reactor temperature of 220oC and a Balanced Gas flowrate of 550-600 KSCFH, the rate of decline in catalyst activity was 0.4% per day, which matched the pefiorrnance at 225"C, as well as the 4-month proof-of-concept run at the LaPorte AFDU in 1988/89. Beginning on 08 May 1998, the LPMEOW Reactor temperature was increased to 235oC, which was the operating temperature tier the December 1997 restart with the fresh charge of catalyst (50'Yo of design loading). The flowrate of the primary syngas feed stream (Balanced Gas) was also increased to 700-750 KSCFH. During two stable operating periods between 08 May and 09 June 1998, the average catalyst deactivation rate was 0.8% per day. Due to the scatter of the statistical analysis of the results, this test was extended to better

  15. Commercial-Scale Demonstration of the Liquid Phase Methanol (LPMEOH) Process

    Energy Technology Data Exchange (ETDEWEB)

    None

    1998-12-21

    The Liquid Phase Methanol (LPMEOW) Demonstration Project at Kingsport Tennessee, is a $213.7 million cooperative agreement between the U.S. Department of Energy (DOE) and Air Products Liquid Phase Conversion Company, L.P. (the Partnership) to produce methanol from coal-derived synthesis gas (syngas). Air Products and Chemicals, Inc. (Air Products) and Eastman Chemical Company (Eastman) formed the Partnership to execute the Demonstration Project. The LPMEOW Process Demonstration Unit was built at a site located at the Eastman complex in Kingsport. During this quarter, initial planning and procurement work began on the seven project sites which have been accepted for participation in the off-site, methanol product-use test plan. Two of the projects have begun pre-testing of equipment and three other projects have commenced with equipment procurement, Methanol produced from carbon monoxide (CO)- rich syngas at the Alternative Fuels Development Unit (AFDU) in LaPorte, TX has been shipped to four of the project sites in anticipation of the start of testing during the first quarter of calendar year 1998. Catalyst activity, as defined by the ratio of the rate constant at any point in time to the rate constant for a freshly reduced catalyst (as determined in the laboratory autoclave), continued to decline more rapidly than expected. In response to concentrations of arsenic and sulfbr detected on catalyst samples from the LPMEOW Reactor, Eastman replaced both the arsine- and sulfiwremoval material in the Eastman guard bed which treats the primary syngas feed stream (&danced Gas) prior to its introduction into both the Eastman fixed-bed methanol plant and the LPMEOWM Demonstration Unit. After restarting the demonstration unit, the catalyst deactivation rate remained essentially unchanged. Parallel testing in the laboratory using arsine-doped, and subsequently arsine- and SuIfi-doped syngas, ako ftiIed to prove that arsine was responsible for the higher-than-expected rate of

  16. Treatment feasibility of the acidic intermediate level radioactive liquid waste - a laboratory scale study

    International Nuclear Information System (INIS)

    The acidic ILW from PREFRE-2 have higher concentrations of U, Fe, Mn and TBP degraded products. During the pretreatment of this acidic ILW prior to ion exchange process, there was formation of large volumes of precipitate having poor settling characteristics. This was reducing the throughput of the processing plant. Laboratory scale studies were carried out to remove the precipitating constituents by solvent extraction using Di - 2 -Ethyl Hexyl Phosporic acid (D2EHPA). In single contact almost 99 % of U and Fe got extracted in D2EHPA in 0.2 M acidic condition. After making alkaline the aqueous part forms only small quantities of Mn(OH)2 precipitate. Decant of this is amenable for conventional ion exchange treatment. The low active effluent from RF resin column is amenable for chemical co-precipitation treatment. (author)

  17. Design and Simulation of Lab-on-a-Chip Devices

    DEFF Research Database (Denmark)

    Dimaki, Maria; Okkels, Fridolin

    2015-01-01

    Microfluidic channels are an essential part of any lab-on-a-chip system. They usually perform various functions, such as transporting liquids from A to B or mixing or separating liquids. As production costs for such systems are not insignificant, it is essential that the systems are designed...

  18. The effect of entrapped nonaqueous phase liquids on tracer transport in heterogeneous porous media: Laboratory experiments at the intermediate scale

    Science.gov (United States)

    Barth, G.R.; Illangasekare, T.H.; Rajaram, H.

    2003-01-01

    This work considers the applicability of conservative tracers for detecting high-saturation nonaqueous-phase liquid (NAPL) entrapment in heterogeneous systems. For this purpose, a series of experiments and simulations was performed using a two-dimensional heterogeneous system (10??1.2 m), which represents an intermediate scale between laboratory and field scales. Tracer tests performed prior to injecting the NAPL provide the baseline response of the heterogeneous porous medium. Two NAPL spill experiments were performed and the entrapped-NAPL saturation distribution measured in detail using a gamma-ray attenuation system. Tracer tests following each of the NAPL spills produced breakthrough curves (BTCs) reflecting the impact of entrapped NAPL on conservative transport. To evaluate significance, the impact of NAPL entrapment on the conservative-tracer breakthrough curves was compared to simulated breakthrough curve variability for different realizations of the heterogeneous distribution. Analysis of the results reveals that the NAPL entrapment has a significant impact on the temporal moments of conservative-tracer breakthrough curves. ?? 2003 Elsevier B.V. All rights reserved.

  19. Quality requirements for forest chips; Kaeyttaejien laatuvaatimukset metsaehakkeelle

    Energy Technology Data Exchange (ETDEWEB)

    Impola, R. [VTT Energy, Jyvaeskylae (Finland)

    1999-07-01

    utilization of forest chips. Increasing utilization volumes may require industrial-scale production of forest chips. By using proper storage arrangements, it is possible to guarantee the better quality of forest chips and the deliveries all year round even when the road conditions are poor. Significant factors effecting on the utilization of forest chips in the future are also the price of the chips and the price-competitiveness on site compared to other fuels.

  20. ANALYTICAL CHIP FORMATION MODEL OF MICRO-END-MILLING

    Institute of Scientific and Technical Information of China (English)

    LI Chengfeng; LAI Xinmin; LI Hongtao; PENG Linfa; NI Jun

    2008-01-01

    A new analytical chip formation model is proposed for micro-end-milling operations. The model calculates an instantaneous uncut chip thickness by considering the combination of exact trochoidal trajectory of the tool tip and tool run-out, while the simplified circular trajectory and the neglected run-out create negligible change in conventional-scale chip formation models. Newton-Raphson iterative method is employed during the calculation to obtain quadratic convergence. The proposed approach allows the calculation of instantaneous uncut chip thickness to be done accurately and rapidly, and the prediction accuracy of this model is also verified by comparing the simulation results to experimental cutting forces.

  1. Chip Multithreaded Consistency Model

    Institute of Scientific and Technical Information of China (English)

    Zu-Song Li; Dan-Dan Huan; Wei-Wu Hu; Zhi-Min Tang

    2008-01-01

    Multithreaded technique is the developing trend of high performance processor. Memory consistency model is essential to the correctness, performance and complexity of multithreaded processor. The chip multithreaded consistency model adapting to multithreaded processor is proposed in this paper. The restriction imposed on memory event ordering by chip multithreaded consistency is presented and formalized. With the idea of critical cycle built by Wei-Wu Hu, we prove that the proposed chip multithreaded consistency model satisfies the criterion of correct execution of sequential consistency model. Chip multithreaded consistency model provides a way of achieving high performance compared with sequential consistency model and ensures the compatibility of software that the execution result in multithreaded processor is the same as the execution result in uniprocessor. The implementation strategy of chip multithreaded consistency model in Godson-2 SMT processor is also proposed. Godson-2 SMT processor supports chip multithreaded consistency model correctly by exception scheme based on the sequential memory access queue of each thread.

  2. Use of forest chips in Finland. Position paper for 1999

    International Nuclear Information System (INIS)

    Finland has decided to raise the energy use of forest chips to 5 million m3 solid by 2010. This corresponds to 0.9 million tonnes of oil equivalent. In order to monitor the ongoing development and the effectiveness of energy policy matters, the Wood Energy Technology Program of Tekes executed a survey of the use of forest chips in 1999. Forest chips were used in 135 heating plants (minimum size 0,5 MW), 21 power plants, and several thousands of small buildings and farm houses. The commercial use was 567 000 m3 solid and small-scale non- commercial use 180 000 m3 solid. The use of forest chips is increasing rapidly especially in combined production of heat and electricity. The report gives information on the use in plants of different size, seasonal variation of use, raw material sources of chips, moisture content of chips, and the development of prices. During the 1990s, the average price of forest chips was reduced by 35 %. In 1999, the average price at the plant was 61 FIM/MWh for whole-tree chips, 44 FIM/MWh for chips reduced from logging residues from forest regeneration areas, and 53 FIM/MWh for the entire flow of forest chips, VAT excluded. (orig.)

  3. Use of pilot plant scale continuous fryer to simulate industrial production of potato chips: thermal properties of palm olein blends under continuous frying conditions.

    Science.gov (United States)

    Tarmizi, Azmil Haizam Ahmad; Ismail, Razali

    2014-01-01

    Binary blends of palm olein (PO) with sunflower oil (SFO), canola oil (CNO), and cottonseed oil (CSO) were formulated to assess their stability under continuous frying conditions. The results were then compared with those obtained in PO. The oil blends studied were: (1) 60:40 for PO + SFO; (2) 70:30 for PO + CNO; and (3) 50:50 for PO + CSO. The PO and its blends were used to fry potato chips at 180°C for a total of 56 h of operation. The evolution of analytical parameters such as tocols, induction period, color, p-anisidine value, free fatty acid, smoke point, polar compounds, and polymer compounds were evaluated over the frying time. Blending PO with unsaturated oils was generally proved to keep most qualitative parameters comparable to those demonstrated in PO. Indeed, none of the oils surpassed the legislative limits for used frying. Overall, it was noted that oil containing PO and SFO showed higher resistance toward oxidative and hydrolytic behaviors as compared to the other oil blends. PMID:24804062

  4. Chlorhexidine Chip in the Treatment of Chronic Periodontitis – A Clinical Study

    OpenAIRE

    Medaiah, Sangeetha; Srinivas, M; Melath, Anil; Girish, Suragimath; Polepalle, Tejaswin; Dasari, Ankineedu Babu

    2014-01-01

    Aim: The aim of this study was to clinically evaluate the use of biodegradable chlorhexidine chip when used as an adjunct to scaling and root planing (SRP) in the treatment of moderate to severe periodontitis patients. The study also intended to compare the combined therapy (SRP and Chlorhexidine chip) with chlorhexidine chip alone in individuals with periodontitis.

  5. Implementation of Guaranteed Services in the MANGO Clockless Network-on-Chip

    DEFF Research Database (Denmark)

    Bjerregaard, Tobias; Sparsø, Jens

    2006-01-01

    Shared, segmented, on-chip interconnection networks, known as networks-on-chip (NoC), may become the preferred way of interconnecting intellectual property (IP) cores in future giga-scale system-on-chip (SoC) designs. A NoC can provide the required communication bandwidth while accommodating the...

  6. Scale-up of industrial biodiesel production to 40 m(3) using a liquid lipase formulation.

    Science.gov (United States)

    Price, Jason; Nordblad, Mathias; Martel, Hannah H; Chrabas, Brent; Wang, Huali; Nielsen, Per Munk; Woodley, John M

    2016-08-01

    In this work, we demonstrate the scale-up from an 80 L fed-batch scale to 40 m(3) along with the design of a 4 m(3) continuous process for enzymatic biodiesel production catalyzed by NS-40116 (a liquid formulation of a modified Thermomyces lanuginosus lipase). Based on the analysis of actual pilot plant data for the transesterification of used cooking oil and brown grease, we propose a method applying first order integral analysis to fed-batch data based on either the bound glycerol or free fatty acid content in the oil. This method greatly simplifies the modeling process and gives an indication of the effect of mixing at the various scales (80 L to 40 m(3) ) along with the prediction of the residence time needed to reach a desired conversion in a CSTR. Suitable process metrics reflecting commercial performance such as the reaction time, enzyme efficiency, and reactor productivity were evaluated for both the fed-batch and CSTR cases. Given similar operating conditions, the CSTR operation on average, has a reaction time which is 1.3 times greater than the fed-batch operation. We also showed how the process metrics can be used to quickly estimate the selling price of the enzyme. Assuming a biodiesel selling price of 0.6 USD/kg and a one-time use of the enzyme (0.1% (w/woil ) enzyme dosage); the enzyme can then be sold for 30 USD/kg which ensures that that the enzyme cost is not more than 5% of the biodiesel revenue. Biotechnol. Bioeng. 2016;113: 1719-1728. © 2016 Wiley Periodicals, Inc. PMID:26806356

  7. High-throughput screening for ionic liquids dissolving (ligno-)cellulose.

    Science.gov (United States)

    Zavrel, Michael; Bross, Daniela; Funke, Matthias; Büchs, Jochen; Spiess, Antje C

    2009-05-01

    The recalcitrance of lignocellulosic biomass poses a major challenge for its sustainable and cost-effective utilization. Therefore, an efficient pretreatment is decisive for processes based on lignocellulose. A green and energy-efficient pretreatment could be the dissolution of lignocellulose in ionic liquids. Several ionic liquids were identified earlier which are capable to dissolve (ligno-)cellulose. However, due to their multitude and high costs, a high-throughput screening on small scale is essential for the determination of the most efficient ionic liquid. In this contribution two high-throughput systems are presented based on extinction or scattered light measurements. Quasi-continuous dissolution profiles allow a direct comparison of up to 96 ionic liquids per experiment in terms of their dissolution kinetics. The screening results indicate that among the ionic liquids tested EMIM Ac is the most efficient for dissolving cellulose. Moreover, it was observed that AMIM Cl is the most effective ionic liquid for dissolving wood chips. PMID:19157872

  8. Flexible packaging of solid-state integrated circuit chips with elastomeric microfluidics

    OpenAIRE

    Bowei Zhang; Quan Dong; Korman, Can E.; Zhenyu Li; Zaghloul, Mona E.

    2013-01-01

    A flexible technology is proposed to integrate smart electronics and microfluidics all embedded in an elastomer package. The microfluidic channels are used to deliver both liquid samples and liquid metals to the integrated circuits (ICs). The liquid metals are used to realize electrical interconnects to the IC chip. This avoids the traditional IC packaging challenges, such as wire-bonding and flip-chip bonding, which are not compatible with current microfluidic technologies. As a demonstratio...

  9. CHIP, CHIP, ARRAY! THREE CHIPS FOR POST-GENOMIC RESEARCH

    Science.gov (United States)

    Cambridge Healthtech Institute recently held the 4th installment of their popular "Lab-on-a-Chip" series in Zurich, Switzerland. As usual, it was enthusiastically received and over 225 people attended the 2-1/2 day meeting to see and hear about some of the latest developments an...

  10. Mathematical Simulation for Integrated Linear Fresnel Spectrometer Chip

    Science.gov (United States)

    Park, Yeonjoon; Yoon, Hargoon; Lee, Uhn; King, Glen C.; Choi, Sang H.

    2012-01-01

    A miniaturized solid-state optical spectrometer chip was designed with a linear gradient-gap Fresnel grating which was mounted perpendicularly to a sensor array surface and simulated for its performance and functionality. Unlike common spectrometers which are based on Fraunhoffer diffraction with a regular periodic line grating, the new linear gradient grating Fresnel spectrometer chip can be miniaturized to a much smaller form-factor into the Fresnel regime exceeding the limit of conventional spectrometers. This mathematical calculation shows that building a tiny motionless multi-pixel microspectrometer chip which is smaller than 1 cubic millimter of optical path volume is possible. The new Fresnel spectrometer chip is proportional to the energy scale (hc/lambda), while the conventional spectrometers are proportional to the wavelength scale (lambda). We report the theoretical optical working principle and new data collection algorithm of the new Fresnel spectrometer to build a compact integrated optical chip.

  11. Mathematical simulation for integrated linear Fresnel spectrometer chip

    Science.gov (United States)

    Park, Yeonjoon; Yoon, Hargsoon; Lee, Uhn; King, Glen C.; Choi, Sang

    2012-04-01

    A miniaturized solid-state optical spectrometer chip was designed with a linear gradient-gap Fresnel grating which was mounted perpendicularly to a sensor array surface and simulated for its performance and functionality. Unlike common spectrometers which are based on Fraunhoffer diffraction with a regular periodic line grating, the new linear gradient grating Fresnel spectrometer chip can be miniaturized to a much smaller form-factor into the Fresnel regime exceeding the limit of conventional spectrometers. This mathematical calculation shows that building a tiny motionless multi-pixel microspectrometer chip which is smaller than 1mm3 of optical path volume is possible. The new Fresnel spectrometer chip is proportional to the energy scale (hc/λ), while the conventional spectrometers are proportional to the wavelength scale (λ). We report the theoretical optical working principle and new data collection algorithm of the new Fresnel spectrometer to build a compact integrated optical chip.

  12. ALICE chip processor

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    This tiny chip provides data processing for the time projection chamber on ALICE. Known as the ALICE TPC Read Out (ALTRO), this device was designed to minimize the size and power consumption of the TPC front end electronics. This single chip contains 16 low-power analogue-to-digital converters with six million transistors of digital processing and 8 kbits of data storage.

  13. On-chip integrated lasers for biophotonic applications

    DEFF Research Database (Denmark)

    Mappes, Timo; Wienhold, Tobias; Bog, Uwe;

    Meeting the need of biomedical users, we develop disposable Lab-on-a-Chip systems based on commercially available polymers. We are combining passive microfluidics with active optical elements on-chip by integrating multiple solid-state and liquid-core lasers. While covering a wide range of laser...... emission wavelengths, the chips have the size of microscope cover slips and use optical and fluidic interconnects only. Here, we present our latest realizations of integrated optofluidic lasers using whispering gallery mode or distributed feedback laser cavities....

  14. Optimization of process parameters for pilot-scale liquid-state bioconversion of sewage sludge by mixed fungal inoculation.

    Science.gov (United States)

    Rahman, Roshanida A; Molla, Abul Hossain; Barghash, Hind F A; Fakhru'l-Razi, Ahmadun

    2016-01-01

    Liquid-state bioconversion (LSB) technique has great potential for application in bioremediation of sewage sludge. The purpose of this study is to determine the optimum level of LSB process of sewage sludge treatment by mixed fungal (Aspergillus niger and Penicillium corylophilum) inoculation in a pilot-scale bioreactor. The optimization of process factors was investigated using response surface methodology based on Box-Behnken design considering hydraulic retention time (HRT) and substrate influent concentration (S0) on nine responses for optimizing and fitted to the regression model. The optimum region was successfully depicted by optimized conditions, which was identified as the best fit for convenient multiple responses. The results from process verification were in close agreement with those obtained through predictions. Considering five runs of different conditions of HRT (low, medium and high 3.62, 6.13 and 8.27 days, respectively) with the range of S0 value (the highest 12.56 and the lowest 7.85 g L(-1)), it was monitored as the lower HRT was considered as the best option because it required minimum days of treatment than the others with influent concentration around 10 g L(-1). Therefore, optimum process factors of 3.62 days for HRT and 10.12 g L(-1) for S0 were identified as the best fit for LSB process and its performance was deviated by less than 5% in most of the cases compared to the predicted values. The recorded optimized results address a dynamic development in commercial-scale biological treatment of wastewater for safe and environment-friendly disposal in near future. PMID:26111620

  15. Advanced flip chip packaging

    CERN Document Server

    Lai, Yi-Shao; Wong, CP

    2013-01-01

    Advanced Flip Chip Packaging presents past, present and future advances and trends in areas such as substrate technology, material development, and assembly processes. Flip chip packaging is now in widespread use in computing, communications, consumer and automotive electronics, and the demand for flip chip technology is continuing to grow in order to meet the need for products that offer better performance, are smaller, and are environmentally sustainable. This book also: Offers broad-ranging chapters with a focus on IC-package-system integration Provides viewpoints from leading industry executives and experts Details state-of-the-art achievements in process technologies and scientific research Presents a clear development history and touches on trends in the industry while also discussing up-to-date technology information Advanced Flip Chip Packaging is an ideal book for engineers, researchers, and graduate students interested in the field of flip chip packaging.

  16. Fate of fumonisins during the production of fried tortilla chips.

    Science.gov (United States)

    Voss, K A; Poling, S M; Meredith, F I; Bacon, C W; Saunders, D S

    2001-06-01

    The fate of fumonisin B(1) (FB(1)), a mycotoxin found in corn, during the commercial manufacture of fried tortilla chips was studied. FB(1) and hydrolyzed FB(1) (HFB(1)) concentrations in four lots of corn and in the masa, other intermediates, liquid and waste byproducts, and fried chips were determined by HPLC. FB(1) concentrations in the masa and chips were reduced significantly, up to 80% in the fried chips, compared to that in the raw corn. HFB(1) was also found in the masa and chips, but at low concentrations compared to FB(1). LC-MS analyses corroborated HPLC findings and further showed the presence of partially hydrolyzed FB(1) (PHFB(1)), which, like HFB(1), was formed during the nixtamalization (cooking/steeping the corn in alkaline water to make masa) step and found predominantly in the cooking/steeping liquid and solid waste. No significant amounts of N-(carboxymethyl)-FB(1) or N-(1-deoxy-D-fructos-1-yl)-FB(1), indicative of fumonisin-sugar adduct formation, were found. Thus, FB(1) is removed from corn and diverted into liquid and waste byproducts during the commercial production of fried tortilla chips. Nixtamalization and rinsing are the critical steps, whereas grinding, sheeting, baking, and frying the masa had little effect. PMID:11410018

  17. First-Principles United Atom Force Field for the Ionic Liquid BMIM(+)BF4(-): An Alternative to Charge Scaling.

    Science.gov (United States)

    Son, Chang Yun; McDaniel, Jesse G; Schmidt, J R; Cui, Qiang; Yethiraj, Arun

    2016-04-14

    Molecular dynamics study of ionic liquids (ILs) is a challenging task. While accurate fully polarizable atomistic models exist, they are computationally too demanding for routine use. Most nonpolarizable atomistic models predict diffusion constants that are much lower than experiment. Scaled charge atomistic models are cost-effective and give good results for single component ILs but are in qualitative error for the phase behavior of mixtures, due to inaccurate prediction of the IL cohesive energy. In this work, we present an alternative approach for developing computationally efficient models that importantly preserves both the correct dynamics and cohesive energy of the IL. Employing a "top-down" approach, a hierarchy of coarse-grained models for BMIM(+)BF4(-) are developed by systematically varying the polarization/atomic resolution of the distinct functional groups. Parametrization is based on symmetry-adapted perturbation theory (SAPT) calculations involving the homomolecular species; all cross interactions are obtained from mixing rules, and there are no adjustable parameters. We find that enhanced dynamics from a united-atom description counteracts the effect of reduced polarization, enabling computationally efficient models that exhibit quantitative agreement with experiment for both static and dynamic properties. We give explicit suggestions for reduced-description models that are computationally more efficient, more accurate, and more fundamentally sound than existing nonpolarizable atomistic models. PMID:26900644

  18. Ultrasonic water thickness measurement at gas-liquid interface areas in small-scale core catcher cooling experiment

    International Nuclear Information System (INIS)

    In these experiments, an ultrasonic water thickness measurement at gas-liquid interface areas, which have two types of step procedure was conducted. A the first step, its measurement was performed in the mockup condition as an ultrasonic pre-examination, and as the second step, it was performed as a pre-examination in a small-scale core catcher cooling system before a main-examination of a severe accident and PHWR safety research division at KAERI. By this method, it is possible that an ultrasonic measurement technique for determining the water layer thickness in a wavy and slug flow regime of a horizontal rectangular tube flow has been displayed in real time as A-scan mode and B-scan mode. The data of A-scanned mode were stored where the x-axis represents gap distance value, and the y-axis is only the amplitude of the interfaced area, the data of B-scanned mode can then be changed where the x-axis represents time values and the y-axis represents the value of the water thickness based on using the LabVIEW code. (author)

  19. Causes of stem end chip defect in chipping potatoes

    Science.gov (United States)

    Stem-end chip defect (SECD) is a serious tuber quality concern that affects chipping potatoes. This defect is characterized by dark-colored vascular tissues and adjacent cortical tissues at the tuber stem-end of potato chips after frying. Chips with SECD are unappealing to consumers and raw product ...

  20. 分散聚合法制备液相芯片聚苯乙烯磁性复合微球的研究%Preparation of polystyrene magnetic microspheres for liquid chips by dispersion polymerization

    Institute of Scientific and Technical Information of China (English)

    牛宁宁; 周雷激; 刘国安; 姜淑娟

    2012-01-01

    We present an approach of synthesizing magnetic polystyrene complex microspheres by a facile dispersion polymerization. Monodisperse magnetic polystyrene microspheres, appropriate to construct liquid chip carriers, were prepared via dispersion polymerization by dispersing pre-treated acrylic acid-based magnetic fluid in styrene. The effects of synthetic conditions such as pre-treatment time of acrylic acid-based magnetic fluid, feeding sequence and amount of styrene monomer on particles' conformation and their size distribution have been investigated,and parameters were further optimized accordingly. SEM results indicate that the magnetic microspheres have an average diameter of 7.77 μm with excellent monodispersity(PDI 1.03) and smooth and compact surfaces. Magnetization curve of Fe3O4 nanoparticles was obtained using superconducting quantum magnetometer. Chemical structures and content of magnetic Fe3O4 of the microspheres were characterized and analyzed using FT-IR and TGA methods.%本文将丙烯酸基磁流体均匀分散到苯乙烯单体中,采用分散聚合法制备出了适于构建液相芯片微球载体的单分散性微米级磁性微球.考察了丙烯酸基磁流体预处理时间、加料顺序和单体量对微球形貌和粒径分布的影响及其条件优化.扫描电镜(SEM)显示磁性微球平均粒径为7.77 μm,具有良好的单分散性(多分散指数PDI为1.03),并且表面光滑致密;用超导量子干涉磁强计测量了Fe3O4纳米粒子的磁化曲线;用红外光谱(FT-IR)和热失重(TG)方法表征了磁性微球的化学结构及Fe3O4含量.

  1. Wood chips procurement and research project at the Mikkeli region

    International Nuclear Information System (INIS)

    In 1993-94, a large-scale energywood production chain started as a co-operation project by the Mikkeli city forest office and local forestry societies. In 1995 over 115 000 m3 (about 85 000 MWh of energy) of wood chips were delivered to Pursiala heat and power plant in Mikkeli. About 75 % of these chips was forest processed chips. About 70 % of the forest processed chips was whole tree chips from improvement cuttings of young forest stands and the rest was logging waste chips from regeneration cutting areas. The average total delivery costs of forest processed chips after reduction of energywood and other subsidies were approximately 45 FIM/m3 (60 FIM/MWh) for the whole tree chips and 38 FIM/m3 (50 FIM/MWh) for logging waste chips. The delivery costs of forest processed chips could meet the target of Bioenergy Research Programme (45 FIM/MWh) only in the most favourable cases. In an average the delivery costs were about 9 FIM/MWh more than the price obtained when sold to the heat and power plant. However the wood chip production created 27 new jobs and the increase of income to the local economy was about 2.2 milj. FIM /year. The local communities got new tax revenue about 3 FIM/MWh. The gain for the forestry was approximated to be 5 - 6 FIM/MWh. The resources of forest processed chips were studied on the basis of stand measurements. According to the study the most remarkable energywood resources were in young thinning stands on Oxalis-Myrtillus and Myrtillus forest site types. On Oxalis-Myrtillus type almost every and on Myrtillus type every second stand included energywood more than 40 m3/ha

  2. Application of microfluidic chip to realize controllable pH gradient

    Institute of Scientific and Technical Information of China (English)

    LUO Chunxiong; SUN Manhui; XU Luping; ZHANG Zhiling; C. Crozatier; CHEN Yong; JI Hang

    2005-01-01

    A kind of PH gradient microfluidic chips through soft-lithography microfabrication for isoelectric focusing (IEF) and high performance liquid chromatography (HPLC) is introduced here. These pH gradient chips have the advantages such as easy fabrication, controllable pH range and precision, isoelectric focusing and separation at the same time, low voltage for isoelectric focusing, and time stable pH gradient. This method has potential application to sample preparation, separation and analysis of microfluidic chips.

  3. Optofluidic router based on tunable liquid-liquid mirrors.

    Science.gov (United States)

    Müller, Philipp; Kopp, Daniel; Llobera, Andreu; Zappe, Hans

    2014-02-21

    We present an electrically tunable 1 × 5 optofluidic router for on-chip light routing. The device can redirect light from an optical input channel into five output channels by exploiting total internal reflection (TIR) at a liquid-liquid interface. The liquid-liquid mirrors, demonstrated for the first time, are tuned using integrated electrowetting-on-dielectrics (EWOD) actuators. The router is assembled from two chips fabricated by standard MEMS techniques. Through a combination of microfluidic with micro-optical components on chip, reliable light routing is achieved with switching times of [1.5-3.3] s, efficiencies of coupling into channels of up to 12%, optical cross-talk as low as -24 dB, a required drive voltage of 50 V, and a low power consumption of router could thus lead to novel laboratory measurement systems. PMID:24287814

  4. Utilization of milli-scale coiled flow inverter in combination with phase separator for continuous flow liquid-liquid extraction processes

    NARCIS (Netherlands)

    Vural Gürsel, Iris; Kurt, Safa Kutup; Aalders, Jasper; Wang, Qi; Noël, Timothy; Nigam, Krishna D P; Kockmann, Norbert; Hessel, Volker

    2016-01-01

    Process-design intensification situated under the umbrella of Novel Process Windows heads for process integration and here most development is needed for flow separators. The vision is to achieve multi-step synthesis in flow on pilot scale. This calls for scale-up of separation units. This study is

  5. Medicaid CHIP ESPC Database

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Environmental Scanning and Program Characteristic (ESPC) Database is in a Microsoft (MS) Access format and contains Medicaid and CHIP data, for the 50 states...

  6. Utilization of titanium chips

    International Nuclear Information System (INIS)

    Complex of equipment is created for realization of developed technology in experimental-inductrial production of secondary titanium alloys with annual efficiency of 50-100 t. The complex includes a section for chips preparation, facility for electride vacuum hot pressins, vacuum arc furnace for melting ingots of <200 kg. The ingots obtained will be reprocessed into bars, forgins, powers and also be used for production of shaped castings. Approbation of the developed technology was carried out by production of three types of secondary titanium lloys. The technical titanium chips were used as blend for production of TV1 alloy, chips of VT5 and PT3V alloys for TV2 and chips of VT6 and VT23 alloys for TV3 alloys. Study of chemical composition, mechanical properties and structure of secondary titanium alloys were performed on forged bars 20 mm in diameter

  7. China's first WLAN chips

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ The wireless local area network (WLAN) chips independently developed by CAS researchers were in the limelight of the recent Electronic Manufacture Exposition held in Suzhou, east China's Jiangsu Province.

  8. Progress in Atom Chips and the Integration of Optical Microcavities

    Science.gov (United States)

    Hinds, E. A.; Trupke, M.; Darquie, B.; Goldwin, J.; Dutier, G.

    2008-04-01

    We review recent progress at the Centre for Cold Matter in developing atom chips. An important advantage of miniaturizing atom traps on a chip is the possibility of obtaining very tight trapping structures with the capability of manipulating atoms on the micron length scale. We recall some of the pros and cons of bringing atoms close to the chip surface, as is required in order to make small static structures, and we discuss the relative merits of metallic, dielectric and superconducting chip surfaces. We point out that the addition of integrated optical devices on the chip can enhance its capability through single atom detection and controlled photon production. Finally, we review the status of integrated microcavities that have recently been demonstrated at our Centre and discuss their prospects for future development.

  9. Simple setup for gas-phase H/D exchange mass spectrometry coupled to electron transfer dissociation and ion mobility for analysis of polypeptide structure on a liquid chromatographic time scale.

    Science.gov (United States)

    Mistarz, Ulrik H; Brown, Jeffery M; Haselmann, Kim F; Rand, Kasper D

    2014-12-01

    Gas-phase hydrogen/deuterium exchange (HDX) is a fast and sensitive, yet unharnessed analytical approach for providing information on the structural properties of biomolecules, in a complementary manner to mass analysis. Here, we describe a simple setup for ND3-mediated millisecond gas-phase HDX inside a mass spectrometer immediately after ESI (gas-phase HDX-MS) and show utility for studying the primary and higher-order structure of peptides and proteins. HDX was achieved by passing N2-gas through a container filled with aqueous deuterated ammonia reagent (ND3/D2O) and admitting the saturated gas immediately upstream or downstream of the primary skimmer cone. The approach was implemented on three commercially available mass spectrometers and required no or minor fully reversible reconfiguration of gas-inlets of the ion source. Results from gas-phase HDX-MS of peptides using the aqueous ND3/D2O as HDX reagent indicate that labeling is facilitated exclusively through gaseous ND3, yielding similar results to the infusion of purified ND3-gas, while circumventing the complications associated with the use of hazardous purified gases. Comparison of the solution-phase- and gas-phase deuterium uptake of Leu-Enkephalin and Glu-Fibrinopeptide B, confirmed that this gas-phase HDX-MS approach allows for labeling of sites (heteroatom-bound non-amide hydrogens located on side-chains, N-terminus and C-terminus) not accessed by classical solution-phase HDX-MS. The simple setup is compatible with liquid chromatography and a chip-based automated nanoESI interface, allowing for online gas-phase HDX-MS analysis of peptides and proteins separated on a liquid chromatographic time scale at increased throughput. Furthermore, online gas-phase HDX-MS could be performed in tandem with ion mobility separation or electron transfer dissociation, thus enabling multiple orthogonal analyses of the structural properties of peptides and proteins in a single automated LC-MS workflow. PMID:25375223

  10. Integrated Micro Bio Systems and High Performance Liquid Chromatographic System on Chip%集成在芯片上的微生物系统与高效液相色谱系统

    Institute of Scientific and Technical Information of China (English)

    KITAMORI Takehiko

    2004-01-01

    1 Micro chemical system on chip Micro integrated chemical systems are expected as promising ultra high throughput chemical and bio processors with extremely small volume. Our research groups have proposed and developed the original methodologies for micro integration of general chemical systems as well the electropho-

  11. Ion trap in a semiconductor chip

    Science.gov (United States)

    Stick, D.; Hensinger, W. K.; Olmschenk, S.; Madsen, M. J.; Schwab, K.; Monroe, C.

    2006-01-01

    The electromagnetic manipulation of isolated atoms has led to many advances in physics, from laser cooling and Bose-Einstein condensation of cold gases to the precise quantum control of individual atomic ions. Work on miniaturizing electromagnetic traps to the micrometre scale promises even higher levels of control and reliability. Compared with `chip traps' for confining neutral atoms, ion traps with similar dimensions and power dissipation offer much higher confinement forces and allow unparalleled control at the single-atom level. Moreover, ion microtraps are of great interest in the development of miniature mass-spectrometer arrays, compact atomic clocks and, most notably, large-scale quantum information processors. Here we report the operation of a micrometre-scale ion trap, fabricated on a monolithic chip using semiconductor micro-electromechanical systems (MEMS) technology. We confine, laser cool and measure heating of a single 111Cd+ ion in an integrated radiofrequency trap etched from a doped gallium-arsenide heterostructure.

  12. Ion Trap in a Semiconductor Chip

    CERN Document Server

    Stick, D; Olmschenk, S; Madsen, M J; Schwab, K; Monroe, C

    2006-01-01

    The electromagnetic manipulation of isolated atoms has led to many advances in physics, from laser cooling and Bose-Einstein condensation of cold gases to the precise quantum control of individual atomic ion. Work on miniaturizing electromagnetic traps to the micrometer scale promises even higher levels of control and reliability. Compared with 'chip traps' for confining neutral atoms, ion traps with similar dimensions and power dissipation offer much higher confinement forces and allow unparalleled control at the single-atom level. Moreover, ion microtraps are of great interest in the development of miniature mass spectrometer arrays, compact atomic clocks, and most notably, large scale quantum information processors. Here we report the operation of a micrometer-scale ion trap, fabricated on a monolithic chip using semiconductor micro-electromechanical systems (MEMS) technology. We confine, laser cool, and measure heating of a single 111Cd+ ion in an integrated radiofrequency trap etched from a doped gallium...

  13. Photonic Wire Bonds for Terabit/s Chip-to-Chip Interconnects

    CERN Document Server

    Lindenmann, Nicole; Hillerkuss, David; Schmogrow, Rene; Jordan, Meinert; Leuthold, Juerg; Freude, Wolfgang; Koos, Christian

    2011-01-01

    Photonic integration has witnessed tremendous progress over the last years, and chip-scale transceiver systems with Terabit/s data rates have come into reach. However, as on-chip integration density increases, efficient off-chip interfaces are becoming more and more crucial. A technological breakthrough is considered indispensable to cope with the challenges arising from large-scale photonic integration, and this particularly applies to short-distance optical interconnects. In this letter we introduce the concept of photonic wire bonding, where transparent waveguide wire bonds are used to bridge the gap between nanophotonic circuits located on different chips. We demonstrate for the first time the fabrication of three-dimensional freeform photonic wire bonds (PWB), and we confirm their viability in a multi-Terabit/s data transmission experiment. First-generation prototypes allow for efficient broadband coupling with overall losses of only 1.6 dB. Photonic wire bonding will enable flexible optical multi-chip a...

  14. Single-chip microprocessor that communicates directly using light.

    Science.gov (United States)

    Sun, Chen; Wade, Mark T; Lee, Yunsup; Orcutt, Jason S; Alloatti, Luca; Georgas, Michael S; Waterman, Andrew S; Shainline, Jeffrey M; Avizienis, Rimas R; Lin, Sen; Moss, Benjamin R; Kumar, Rajesh; Pavanello, Fabio; Atabaki, Amir H; Cook, Henry M; Ou, Albert J; Leu, Jonathan C; Chen, Yu-Hsin; Asanović, Krste; Ram, Rajeev J; Popović, Miloš A; Stojanović, Vladimir M

    2015-12-24

    Data transport across short electrical wires is limited by both bandwidth and power density, which creates a performance bottleneck for semiconductor microchips in modern computer systems--from mobile phones to large-scale data centres. These limitations can be overcome by using optical communications based on chip-scale electronic-photonic systems enabled by silicon-based nanophotonic devices. However, combining electronics and photonics on the same chip has proved challenging, owing to microchip manufacturing conflicts between electronics and photonics. Consequently, current electronic-photonic chips are limited to niche manufacturing processes and include only a few optical devices alongside simple circuits. Here we report an electronic-photonic system on a single chip integrating over 70 million transistors and 850 photonic components that work together to provide logic, memory, and interconnect functions. This system is a realization of a microprocessor that uses on-chip photonic devices to directly communicate with other chips using light. To integrate electronics and photonics at the scale of a microprocessor chip, we adopt a 'zero-change' approach to the integration of photonics. Instead of developing a custom process to enable the fabrication of photonics, which would complicate or eliminate the possibility of integration with state-of-the-art transistors at large scale and at high yield, we design optical devices using a standard microelectronics foundry process that is used for modern microprocessors. This demonstration could represent the beginning of an era of chip-scale electronic-photonic systems with the potential to transform computing system architectures, enabling more powerful computers, from network infrastructure to data centres and supercomputers. PMID:26701054

  15. Single-chip microprocessor that communicates directly using light

    Science.gov (United States)

    Sun, Chen; Wade, Mark T.; Lee, Yunsup; Orcutt, Jason S.; Alloatti, Luca; Georgas, Michael S.; Waterman, Andrew S.; Shainline, Jeffrey M.; Avizienis, Rimas R.; Lin, Sen; Moss, Benjamin R.; Kumar, Rajesh; Pavanello, Fabio; Atabaki, Amir H.; Cook, Henry M.; Ou, Albert J.; Leu, Jonathan C.; Chen, Yu-Hsin; Asanović, Krste; Ram, Rajeev J.; Popović, Miloš A.; Stojanović, Vladimir M.

    2015-12-01

    Data transport across short electrical wires is limited by both bandwidth and power density, which creates a performance bottleneck for semiconductor microchips in modern computer systems—from mobile phones to large-scale data centres. These limitations can be overcome by using optical communications based on chip-scale electronic-photonic systems enabled by silicon-based nanophotonic devices8. However, combining electronics and photonics on the same chip has proved challenging, owing to microchip manufacturing conflicts between electronics and photonics. Consequently, current electronic-photonic chips are limited to niche manufacturing processes and include only a few optical devices alongside simple circuits. Here we report an electronic-photonic system on a single chip integrating over 70 million transistors and 850 photonic components that work together to provide logic, memory, and interconnect functions. This system is a realization of a microprocessor that uses on-chip photonic devices to directly communicate with other chips using light. To integrate electronics and photonics at the scale of a microprocessor chip, we adopt a ‘zero-change’ approach to the integration of photonics. Instead of developing a custom process to enable the fabrication of photonics, which would complicate or eliminate the possibility of integration with state-of-the-art transistors at large scale and at high yield, we design optical devices using a standard microelectronics foundry process that is used for modern microprocessors. This demonstration could represent the beginning of an era of chip-scale electronic-photonic systems with the potential to transform computing system architectures, enabling more powerful computers, from network infrastructure to data centres and supercomputers.

  16. "Chips with Everything": A Laboratory Exercise for Comparing Subjective and Objective Measurements of Potato Chips

    Science.gov (United States)

    Davies, Cathy

    2005-01-01

    The following laboratory exercise was designed to aid student understanding of the differences between subjective and objective measurements. Students assess the color and texture of different varieties of potato chip (crisps) by means of an intensity rating scale and a rank test and objectively with a colorimeter and texture analyzer. For data…

  17. Analysis of the fly ash from the processing of wood chips in a pilot-scale downdraft gasifier: Comparison of inorganic constituents determined by PIXE and ICP-AES

    International Nuclear Information System (INIS)

    Gasification of biomass ultimately generates at least one solid byproduct in which the inorganic constituents of the biomass are concentrated. Given the potential for utilization, or issues with disposal, facile methods are needed for determining the compositions of the fly ashes from recently-available gasifier-based bioenergy systems. Proton induced x-ray emission spectroscopy (PIXE) and inductively coupled plasma atomic emission spectroscopy (ICP-AES) were used to characterize the fly ash recovered from a pilot-scale (25 kW) modular bioenergy system operated with wood chips as the feedstock. The composition of the fly ash from the downdraft gasifier showed some similarities to compositions reported for boiler wood ashes, apart from one half of the material being unburned carbon. Although ICP-AES showed greater sensitivity for the analysis of the fly ash, especially for small amounts of heavy metal contaminants, PIXE proved to be a powerful analytical tool for screening of elements from sodium to uranium. Such broad spectrum screenings could prevent the inadvertent land application of unsuspected pollutant elements. Fly ashes from biomass gasification appear to be suitable for use as ash-based fertilizers for forest lands; however, combustion to remove unburned carbon may be advisable. -- Highlights: ► Fly ash composition data for commercial modular bioenergy systems are now reported. ► PIXE analysis better suited for analysis of fly ashes rich in silicates. Fly ashes generated by biomass gasification may be suitable for land application. ► Combustion of biomass-derived fly ashes is recommended before use as soil amendments

  18. Moving-part-free microfluidic systems for lab-on-a-chip

    International Nuclear Information System (INIS)

    Microfluidic systems are part of an emerging technology which deals with minute amounts of liquids (biological samples and reagents) on a small scale. They are fast, compact and can be made into a highly integrated system to deliver sample purification, separation, reaction, immobilization, labelling, as well as detection, thus are promising for applications such as lab-on-a-chip and handheld healthcare devices. Miniaturized micropumps typically consist of a moving-part component, such as a membrane structure, to deliver liquids, and are often unreliable, complicated in structure and difficult to be integrated with other control electronics circuits. The trend of new-generation micropumps is moving-part-free micropumps operated by advanced techniques, such as electrokinetic force, surface tension/energy, acoustic waves. This paper reviews the development and advances of relevant technologies, and introduces electrowetting-on-dielectrics and acoustic wave-based microfluidics. The programmable electrowetting micropump has been realized to dispense and manipulate droplets in 2D with up to 1000 addressable electrodes and electronics built underneath. The acoustic wave-based microfluidics can be used not only for pumping, mixing and droplet generation but also for biosensors, suitable for single-mechanism-based lab-on-a-chip applications

  19. Inherent polarization entanglement generated from a monolithic semiconductor chip

    DEFF Research Database (Denmark)

    Horn, Rolf T.; Kolenderski, Piotr; Kang, Dongpeng;

    2013-01-01

    Creating miniature chip scale implementations of optical quantum information protocols is a dream for many in the quantum optics community. This is largely because of the promise of stability and scalability. Here we present a monolithically integratable chip architecture upon which is built...... filtering or post-selection. After splitting the twin-photons immediately after they emerge from the chip, we perform a variety of correlation tests on the photon pairs and show non-classical behaviour in their polarization. Combined with the BRW's versatile architecture our results signify the BRW design...

  20. Packetizing OCP Transactions in the MANGO Network-on-Chip

    DEFF Research Database (Denmark)

    Bjerregaard, Tobias; Sparsø, Jens

    2006-01-01

    The scaling of CMOS technology causes a widening gap between the performance of on-chip communication and computation. This calls for a communication-centric design flow. The MANGO network-on-chip architecture enables globally asynchronous locally synchronous (GALS) system-on-chip design, while...... transactions are packetized and transmitted across the shared network, and illustrate how this affects the end-to-end performance. A high predictability of the latency of communication on shared links is shown in a MANGO-based demonstrator system...

  1. Price of forest chips decreasing

    International Nuclear Information System (INIS)

    Use of forest chips was studied in 1999 in the national Puuenergia (Wood Energy) research program. Wood combusting heating plants were questioned about are the main reasons restricting the increment of the use of forest chips. Heating plants, which did not use forest chips at all or which used less than 250 m3 (625 bulk- m3) in 1999 were excluded. The main restrictions for additional use of forest chips were: too high price of forest chips; lack of suppliers and/or uncertainty of deliveries; technical problems of reception and processing of forest chips; insufficiency of boiler output especially in winter; and unsatisfactory quality of chips. The price of forest chips becomes relatively high because wood biomass used for production of forest chips has to be collected from wide area. Heavy equipment has to be used even though small fragments of wood are processed, which increases the price of chips. It is essential for forest chips that the costs can be pressed down because competition with fossil fuels, peat and industrial wood residues is hard. Low market price leads to the situation in which forest owner gets no price of the raw material, the entrepreneurs operate at the limit of profitability and renovation of machinery is difficult, and forest chips suppliers have to sell the chips at prime costs. Price of forest chips has decreased significantly during the past decade. Nominal price of forest chips is now lower than two decades ago. The real price of chips has decreased even more than the nominal price, 35% during the past decade and 20% during the last five years. Chips, made of small diameter wood, are expensive because the price includes the felling costs and harvesting is carried out at thinning lots. Price is especially high if chips are made of delimbed small diameter wood due to increased the work and reduced amount of chips. The price of logging residue chips is most profitable because cutting does not cause additional costs. Recovery of chips is

  2. Liquid Oxygen Propellant Densification Production and Performance Test Results With a Large-Scale Flight-Weight Propellant Tank for the X33 RLV

    Science.gov (United States)

    Tomsik, Thomas M.; Meyer, Michael L.

    2010-01-01

    This paper describes in-detail a test program that was initiated at the Glenn Research Center (GRC) involving the cryogenic densification of liquid oxygen (LO2). A large scale LO2 propellant densification system rated for 200 gpm and sized for the X-33 LO2 propellant tank, was designed, fabricated and tested at the GRC. Multiple objectives of the test program included validation of LO2 production unit hardware and characterization of densifier performance at design and transient conditions. First, performance data is presented for an initial series of LO2 densifier screening and check-out tests using densified liquid nitrogen. The second series of tests show performance data collected during LO2 densifier test operations with liquid oxygen as the densified product fluid. An overview of LO2 X-33 tanking operations and load tests with the 20,000 gallon Structural Test Article (STA) are described. Tank loading testing and the thermal stratification that occurs inside of a flight-weight launch vehicle propellant tank were investigated. These operations involved a closed-loop recirculation process of LO2 flow through the densifier and then back into the STA. Finally, in excess of 200,000 gallons of densified LO2 at 120 oR was produced with the propellant densification unit during the demonstration program, an achievement that s never been done before in the realm of large-scale cryogenic tests.

  3. An Evaluation of an Integrated On-Chip/Off-Chip Network for High-Performance Reconfigurable Computing

    OpenAIRE

    Kritikos, William V.; Shanyuan Gao; Andrew G. Schmidt; Ron Sass

    2012-01-01

    As the number of cores per discrete integrated circuit (IC) device grows, the importance of the network on chip (NoC) increases. However, the body of research in this area has focused on discrete IC devices alone which may or may not serve the high-performance computing community which needs to assemble many of these devices into very large scale, parallel computing machines. This paper describes an integrated on-chip/off-chip network that has been implemented on an all-FPGA computing cluster...

  4. DVFS using clock scheduling for Multicore Systems-on-Chip and Networks-on-Chip

    OpenAIRE

    Yadav, Manoj Kumar

    2014-01-01

    A modern System-on-Chip (SoC) contains processor cores, application-specific process- ing elements, memory, peripherals, all connected with a high-bandwidth and low-latency Network-on-Chip (NoC). The downside of such very high level of integration and con- nectivity is the high power consumption. In CMOS technology this is made of a dynamic and a static component. To reduce the dynamic component, Dynamic voltage and Fre- quency Scaling (DVFS) has been adopted. Although DVFS is very effective ...

  5. Ultrasonic Water Thickness Measurement at a Gas-Liquid Interface Area in Full-scale Mockup Experiment

    International Nuclear Information System (INIS)

    The ultrasonic pre-examination in the mockup condition was performed to do an analysis for cooling performance in a complete test channel by the investigation of the two-phase flow that will be developed in an inclined gap with heating from the top. This ultrasonic technique for measuring water layer thickness measurement employs the higher relative acoustic impedance of air with respect to that of liquids. By this method it is possible to determine both liquid water distance, void fraction in a gas-liquid two-phase flow. Instantaneous measurement of the water layer thickness is useful in understanding heat and mass transfer characteristics in a two-phase separated flow. An ultrasonic measurement technique for determining water layer thickness in the wavy and slug flow regime of horizontal tube flow has been produced as an A-scan mode and B-scan mode

  6. Atomic-Scale Structural Evolution and Stability of Supercooled Liquid of a Zr-Based Bulk Metallic Glass

    International Nuclear Information System (INIS)

    In this Letter, direct experimental evidence is provided for understanding the thermal stability with respect to crystallization in the Zr41.2Ti13.8Cu12.5Ni10Be22.5 glass-forming liquid. Through high-resolution transmission electron microscopy, the atomic-structure evolution in the glass-forming liquid during the isothermal annealing process is clearly revealed. In contrast with the existing theoretical models, our results reveal that, prior to nanocrystallization, there exists a metastable state prone to forming icosahedralike atomic clusters, which impede the subsequent crystallization and hence stabilize the supercooled liquid. The outcome of the current research underpins the topological origin for the excellent thermal stability displayed by the Zr-based bulk metallic glass.

  7. Networks on chip

    CERN Document Server

    Jantsch, Axel

    2007-01-01

    From the reviews:""This edited book is concerned with the fundamentals of Networks-on-Chip design. … Overall, the various authors have done an excellent job in covering their material, and the book is well edited. The authors' objectives were that of providing an in-depth, up-to-date, unified and comprehensive treatment ... . These are difficult objectives … and they have done a creditable job of attaining them. In summary, this book is a welcome addition to the literature on networks on chip design … ."" (Mile Stojcev, Microelectronics Reliability, Vol. 44, 2004)

  8. Trapping molecules on chips

    CERN Document Server

    Santambrogio, Gabriele

    2015-01-01

    In the last years, it was demonstrated that neutral molecules can be loaded on a microchip directly from a supersonic beam. The molecules are confined in microscopic traps that can be moved smoothly over the surface of the chip. Once the molecules are trapped, they can be decelerated to a standstill, for instance, or pumped into selected quantum states by laser light or microwaves. Molecules are detected on the chip by time-resolved spatial imaging, which allows for the study of the distribution in the phase space of the molecular ensemble.

  9. A Quality-of-Service Mechanism for Interconnection Networks in System-on-Chips

    CERN Document Server

    Weber, Wolf-Dietrich; Swarbrick, Ian; Wingard, Drew

    2011-01-01

    As Moore's Law continues to fuel the ability to build ever increasingly complex system-on-chips (SoCs), achieving performance goals is rising as a critical challenge to completing designs. In particular, the system interconnect must efficiently service a diverse set of data flows with widely ranging quality-of-service (QoS) requirements. However, the known solutions for off-chip interconnects such as large-scale networks are not necessarily applicable to the on-chip environment. Latency and memory constraints for on-chip interconnects are quite different from larger-scale interconnects. This paper introduces a novel on-chip interconnect arbitration scheme. We show how this scheme can be distributed across a chip for high-speed implementation. We compare the performance of the arbitration scheme with other known interconnect arbitration schemes. Existing schemes typically focus heavily on either low latency of service for some initiators, or alternatively on guaranteed bandwidth delivery for other initiators. ...

  10. Sensing systems using chip-based spectrometers

    Science.gov (United States)

    Nitkowski, Arthur; Preston, Kyle J.; Sherwood-Droz, Nicolás.; Behr, Bradford B.; Bismilla, Yusuf; Cenko, Andrew T.; DesRoches, Brandon; Meade, Jeffrey T.; Munro, Elizabeth A.; Slaa, Jared; Schmidt, Bradley S.; Hajian, Arsen R.

    2014-06-01

    Tornado Spectral Systems has developed a new chip-based spectrometer called OCTANE, the Optical Coherence Tomography Advanced Nanophotonic Engine, built using a planar lightwave circuit with integrated waveguides fabricated on a silicon wafer. While designed for spectral domain optical coherence tomography (SD-OCT) systems, the same miniaturized technology can be applied to many other spectroscopic applications. The field of integrated optics enables the design of complex optical systems which are monolithically integrated on silicon chips. The form factors of these systems can be significantly smaller, more robust and less expensive than their equivalent free-space counterparts. Fabrication techniques and material systems developed for microelectronics have previously been adapted for integrated optics in the telecom industry, where millions of chip-based components are used to power the optical backbone of the internet. We have further adapted the photonic technology platform for spectroscopy applications, allowing unheard-of economies of scale for these types of optical devices. Instead of changing lenses and aligning systems, these devices are accurately designed programmatically and are easily customized for specific applications. Spectrometers using integrated optics have large advantages in systems where size, robustness and cost matter: field-deployable devices, UAVs, UUVs, satellites, handheld scanning and more. We will discuss the performance characteristics of our chip-based spectrometers and the type of spectral sensing applications enabled by this technology.

  11. Up the Technology Readiness Level (TRL) Scale to Demonstrate a Robust, Long Life, Liquid Rocket Engine Combustion Chamber, or...Up the Downstairs

    Science.gov (United States)

    Holmes, Richard; Elam, Sandra; McKechnie, Timothy; Power, Christopher

    2008-01-01

    Advanced vacuum plasma spray (VPS) technology, utilized to successfully apply thermal barrier coatings to space shuttle main engine turbine blades, was further refined as a functional gradient material (FGM) process for space furnace cartridge experiments at 1600 C and for robust, long life combustion chambers for liquid rocket engines. A VPS/FGM 5K (5,000 lb. thrust) thruster has undergone 220 hot firing tests, in pristine condition, showing no wear, blanching or cooling channel cracks. Most recently, this technology has been applied to a 40K thruster, with scale up planned for a 194K Ares I, J-2X engine.

  12. [Informational and analytical system for the support of decision making during liquidation of consequences of a large-scale radiation accident].

    Science.gov (United States)

    Zlatoustov, N N; Bizin, I A; Bondarenko, I M; Kaganov, V M; Grenkova, G K

    2001-07-01

    The developed information and analytic system (IAS) of decision making support in liquidation medical-and-sanitary consequences of the large-scale radiation accidents permits on the base of computer models to evaluate the size and degree of territorial radioactive pollution, the radiation doses, the number and structure of radiation affection, the forces and means of medical service required for rendering the casualties the first medical aid as well as to compare the available and necessary medical forces and means. IAS is intended for equipping the toxicologist-radiologist's working place. To solve the private problems the IAS computer methods can be used both in complex and autonomously. PMID:11561428

  13. Fish and chips

    OpenAIRE

    Delvenne, Philippe; Deprez, Manuel; Bisig, Bettina; JAMAR, Mauricette; Boniver, Jacques; Bours, Vincent; Herens, Christian

    2010-01-01

    Academic hospital laboratories should offer patients the possibility to have the most accurate diagnosis by the development of new analyses, such as molecular biology tests including FISH (Fluorescent In Situ Hybridization) and chips (microarrays,...). The purpose of this article is to describe the principles and the potential applications of these techniques.

  14. A chemically inert multichannel chip-to-world interface to connect microfluidic chips

    Science.gov (United States)

    Neumann, Christiane; Wilhelm, Elisabeth; Duttenhofer, Thomas; Pires, Leonardo; Rapp, Bastian E.

    2014-03-01

    Within the last decades more and more microfluidic systems for applications in chemistry, biology or medicine were developed. Most of them need a connection between the chip and its macroscopic environment e.g., pumps. Numerous concepts for such interconnections are known from literature but most of them allow only a small number of connections and are neither chemically inert nor contamination-free. We developed a chemically inert, reusable, multichannel Chipto- World-Interface (CWI) based on a force fit connection. This principle is comparable to hollow screws as used in highperformance liquid chromatography. The CWI can be used to connect chips, made of different materials, e.g., glass, polydimethylsiloxane (PDMS), or epoxy polymers, with up to 100 thermoplastic tubes. The dimensions of the CWI and the number of connections can be individually adapted depending on the chip dimensions but the pitch between the tubes is fixed. Due to the design of the CWI the fluid is only in contact with the chip and the tubing material, thus leading to a contamination free and zero dead volume interconnection. Using tubes of polytetrafluorethylene (PTFE, Teflon®) even enables probing with organic solvents like dimethylformamide, dichloromethane or tetrahydrofuran over several hours without leakage or corrosion of the CWI. During experiments the CWI with 100 connections resisted pressure up to 630 kPa (6.3 bar) and sustained flow rates higher than 4 ml/min.

  15. Studies on structural, thermal and AC conductivity scaling of PEO-LiPF6 polymer electrolyte with added ionic liquid [BMIMPF6

    Science.gov (United States)

    Chaurasia, S. K.; Saroj, A. L.; Shalu, Singh, V. K.; Tripathi, A. K.; Gupta, A. K.; Verma, Y. L.; Singh, R. K.

    2015-07-01

    Preparation and characterization of polymer electrolyte films of PEO+10wt.% LiPF6 + xwt.% BMIMPF6 (1-butyl-3-methylimidazolium hexafluorophosphate) containing dopant salt lithium hexafluorophosphate (LiPF6) and ionic liquid (BMIMPF6) having common anion PF6 - are reported. The ionic conductivity of the polymer electrolyte films has been found to increase with increasing concentration of BMIMPF6 in PEO+10 wt.% LiPF6 due to the plasticization effect of ionic liquid. DSC and XRD results show that the crystallinity of polymer electrolyte decreases with BMIMPF6 concentration which, in turn, is responsible for the increase in ionic conductivity. FTIR spectroscopic study shows the complexation of salt and/or ionic liquid cations with the polymer backbone. Ion dynamics behavior of PEO+LiPF6 as well as PEO+LiPF6 + BMIMPF6 polymer electrolytes was studied by frequency dependent conductivity, σ(f) measurements. The values σ(f) at various temperatures have been analyzed in terms of Jonscher power law (JPL) and scaled with respect to frequency which shows universal power law characteristics at all temperatures.

  16. Effect of gas-liquid flow pattern and microbial diversity analysis of a pilot-scale biotrickling filter for anoxic biogas desulfurization.

    Science.gov (United States)

    Almenglo, Fernando; Bezerra, Tercia; Lafuente, Javier; Gabriel, David; Ramírez, Martín; Cantero, Domingo

    2016-08-01

    Hydrogen sulfide removal from biogas was studied under anoxic conditions in a pilot-scale biotrickling filter operated under counter- and co-current gas-liquid flow patterns. The best performance was found under counter-current conditions (maximum elimination capacity of 140 gS m(-3) h(-1)). Nevertheless, switching conditions between co- and counter-current flow lead to a favorable redistribution of biomass and elemental sulfur along the bed height. Moreover, elemental sulfur was oxidized to sulfate when the feeding biogas was disconnected and the supply of nitrate (electron acceptor) was maintained. Removal of elemental sulfur was important to prevent clogging in the packed bed and, thereby, to increase the lifespan of the packed bed between maintenance episodes. The larger elemental sulfur removal rate during shutdowns was 59.1 gS m(-3) h(-1). Tag-encoded FLX amplicon pyrosequencing was used to study the diversity of bacteria under co-current flow pattern with liquid recirculation and counter-current mode with a single-pass flow of the liquid phase. The main desulfurizing bacteria were Sedimenticola while significant role of heterotrophic, opportunistic species was envisaged. Remarkable differences between communities were found when a single-pass flow of industrial water was fed to the biotrickling filter. PMID:27231880

  17. Estimate the thermomechanical fatigue life of two flip chip packages

    International Nuclear Information System (INIS)

    The continuing demand towards high density and low profile integrated circuit packaging has accelerated the development of flip chip structures as used in direct chip attach (DCA) technology, ball grid array (BOA) and chip scale package (CSP). In such structures the most widely used flip chip interconnects are solder joints. The reliability of flip chip structures largely depends on the reliability of solder joints. In this work solder joint fatigue life prediction for two chip scale packages is carried out. Elasto-plastic deformation behavior of the solder was simulated using ANSYS. Two dimensional plain strain finite element models were developed for each package to numerically compute the stress and total strain of the solder joints under temperature cycling. These stress and strain values are then used to predict the solder joint lifetime through modified Coffin Manson equation. The effect of solder joint's distance from edge of silicon die on life of the package is explored. The solder joint fatigue response is modeled for a typical temperature cycling of -60 to 140 degree C. (author)

  18. Hardware support for CSP on a Java chip multiprocessor

    DEFF Research Database (Denmark)

    Gruian, Flavius; Schoeberl, Martin

    2013-01-01

    Due to memory bandwidth limitations, chip multiprocessors (CMPs) adopting the convenient shared memory model for their main memory architecture scale poorly. On-chip core-to-core communication is a solution to this problem, that can lead to further performance increase for a number of multithreaded...... applications. Programmatically, the Communicating Sequential Processes (CSPs) paradigm provides a sound computational model for such an architecture with message based communication. In this paper we explore hardware support for CSP in the context of an embedded Java CMP. The hardware support for CSP are on-chip...... communication channels, implemented by a ring-based network-on-chip (NoC), to reduce the memory bandwidth pressure on the shared memory.The presented solution is scalable and also specific for our limited resources and real-time predictability requirements. CMP architectures of three to eight processors were...

  19. Chip breaking system for automated machine tool

    Science.gov (United States)

    Arehart, Theodore A.; Carey, Donald O.

    1987-01-01

    The invention is a rotary selectively directional valve assembly for use in an automated turret lathe for directing a stream of high pressure liquid machining coolant to the interface of a machine tool and workpiece for breaking up ribbon-shaped chips during the formation thereof so as to inhibit scratching or other marring of the machined surfaces by these ribbon-shaped chips. The valve assembly is provided by a manifold arrangement having a plurality of circumferentially spaced apart ports each coupled to a machine tool. The manifold is rotatable with the turret when the turret is positioned for alignment of a machine tool in a machining relationship with the workpiece. The manifold is connected to a non-rotational header having a single passageway therethrough which conveys the high pressure coolant to only the port in the manifold which is in registry with the tool disposed in a working relationship with the workpiece. To position the machine tools the turret is rotated and one of the tools is placed in a material-removing relationship of the workpiece. The passageway in the header and one of the ports in the manifold arrangement are then automatically aligned to supply the machining coolant to the machine tool workpiece interface for breaking up of the chips as well as cooling the tool and workpiece during the machining operation.

  20. A single chip microcontroller based portable multichannel analyzer

    International Nuclear Information System (INIS)

    The development of a portable multichannel analyzer for gamma spectroscopy applications is described. The developed unit is based on the Intel 8751 single chip microcontroller and has CRT and liquid crystal displays, preamplifying and amplifying sections, high voltage supply, built-in printer and runs on rechargeable batteries. The design uses standard off the shelf components, minimizes chip count by using all the microcontroller's resources and implementing most functions in software, and this results in a low cost system with good performance. Hardware and software design along with their integration are discussed. (orig.)

  1. Development of a fast thermal response microfluidic system using liquid metal

    Science.gov (United States)

    Gao, Meng; Gui, Lin

    2016-07-01

    Room temperature liquid metal gallium alloy has been widely used in many micro-electromechanical systems applications, such as on-chip electrical microheaters, micro temperature sensors, micro pumps and so on. Injecting liquid metal into microchannels can provide a simple, rapid, low-cost but efficient way to integrate these elements in microfluidic chips with high accuracy. The liquid metal-filled microstructures can be designed in any shape and easily integrated into microfluidic chips. In this paper, an on-chip liquid metal-based thermal microfluidic system is proposed for quick temperature control at the microscale. The micro system utilizes just one microfluidic chip as a basic working platform, which has liquid metal-based on-chip heaters, temperature sensors and electroosmotic flow pumps. Under the comprehensive control of these elements, the micro system can quickly change the temperature of a target fluid in the microfluidic chip. These liquid metal-based on-chip elements are very helpful for the fabrication and miniaturization of the microfluidic chip. In this paper, deionized water is used to test the temperature control performance of the thermal microfluidic system. According to the experimental results, the micro system can efficiently control the temperature of water ranging from 28 °C to 90 °C. The thermal microfluidic system has great potential for use in many microfluidic applications, such as on-chip polymerase chain reaction, temperature gradient focusing, protein crystallization and chemical synthesis.

  2. Membranes for nanometer-scale mass fast transport

    Science.gov (United States)

    Bakajin, Olgica; Holt, Jason; Noy, Aleksandr; Park, Hyung Gyu

    2011-10-18

    Nanoporous membranes comprising single walled, double walled, and multiwalled carbon nanotubes embedded in a matrix material were fabricated for fluid mechanics and mass transfer studies on the nanometer scale and commercial applications. Average pore size can be 2 nm to 20 nm, or seven nm or less, or two nanometers or less. The membrane can be free of large voids spanning the membrane such that transport of material such as gas or liquid occurs exclusively through the tubes. Fast fluid, vapor, and liquid transport are observed. Versatile micromachining methods can be used for membrane fabrication. A single chip can comprise multiple membranes. These membranes are a robust platform for the study of confined molecular transport, with applications in liquid and gas separations and chemical sensing including desalination, dialysis, and fabric formation.

  3. Non-Fermi-liquid scaling in heavy-fermion UCu3.5Al1.5 and UCu3Al2

    International Nuclear Information System (INIS)

    We report on specific-heat, magnetic-susceptibility, high-field-magnetization, electrical-resistivity, and neutron-diffraction results on UCu3.5Al1.5 (polycrystal) and UCu3Al2 (polycrystal and single crystal). Our results indicate that both compounds crystallize in the hexagonal CaCu5 structure with ordered UCu2 planes separated by planes containing a statistical distribution of Al along with the remaining Cu atoms. At low temperatures, the specific heat and the magnetic susceptibility of both compounds are enhanced, but their temperature dependences are found to be distinct from expectations of Fermi-liquid theory. UCu3.5Al1.5 does not order magnetically, and the low-temperature specific heat and magnetic susceptibility show scaling behavior (C/T∝lnT and χ∝T-1/3) reminiscent of non-Fermi-liquid materials. For UCu3Al2, on the other hand, the low-temperature scaling of bulk properties is masked by an anomaly around 8 endash 10 K, which is presumably of magnetic origin. Single-crystal studies of UCu3Al2 reveal a huge magnetic anisotropy with very different in-plane response compared to the c-axis response. Our data provide evidence that any temperature dependence of the magnetic susceptibility (and electrical resistivity) of polycrystalline material may be due to averaging anisotropic response over all crystallographic directions. The results are discussed in the context of findings from other non-Fermi-liquid materials. copyright 1996 The American Physical Society

  4. Immersion cooling nucleate boiling of high power computer chips

    International Nuclear Information System (INIS)

    Highlights: ► Experimental investigations of nucleate boiling of dielectric liquids on porous graphite (PG). ► Marked enhancements in nucleate boiling heat transfer coefficient and CHF. ► Critical heat flux (CHF) increases linearly with increased liquid subcooling. ► PG–Cu spreaders for cooling 10 × 10 computer chips remove up to 100 W. - Abstract: This paper presents experimental results of saturation and subcooled boiling of FC-72 and HFE-7100 dielectric liquids on uniformly heated, 10 × 10 mm porous graphite (PG) surfaces for potential applications to immersion cooling of high power computer chips. The experiments investigated the effects of surface inclination, from upward-facing (0°) to downward-facing (180°), and liquid subcooling from 0 to 30 K on nucleate boiling heat transfer coefficient and critical heat flux. The presented experimental data and correlations for natural convection of dielectric liquids on PG and plane surfaces are important for cooling chips while in the standby mode when surface heat flux 2. The experimental curves of the nucleate boiling heat transfer coefficient for FC-72 dielectric liquid in the upward-facing orientation are used in 3-D thermal analysis for sizing and quantifying the performance of copper (Cu), PG and PG–Cu composite spreaders for removing the dissipated thermal power by an underlying 10 × 10 mm computer chip with non-uniform heat dissipation. The 2 mm-thick spreaders are cooled by either saturation or 30 K subcooled nucleate boiling of FC-72 and the composite spreader consists of 0.4 mm-thick surface layer of PG and 1.6 mm-thick Cu substrate.

  5. Invisibility Cloak Printed on a Photonic Chip

    Science.gov (United States)

    Feng, Zhen; Wu, Bing-Hong; Zhao, Yu-Xi; Gao, Jun; Qiao, Lu-Feng; Yang, Ai-Lin; Lin, Xiao-Feng; Jin, Xian-Min

    2016-01-01

    Invisibility cloak capable of hiding an object can be achieved by properly manipulating electromagnetic field. Such a remarkable ability has been shown in transformation and ray optics. Alternatively, it may be realistic to create a spatial cloak by means of confining electromagnetic field in three-dimensional arrayed waveguides and introducing appropriate collective curvature surrounding an object. We realize the artificial structure in borosilicate by femtosecond laser direct writing, where we prototype up to 5,000 waveguides to conceal millimeter-scale volume. We characterize the performance of the cloak by normalized cross correlation, tomography analysis and continuous three-dimensional viewing angle scan. Our results show invisibility cloak can be achieved in waveguide optics. Furthermore, directly printed invisibility cloak on a photonic chip may enable controllable study and novel applications in classical and quantum integrated photonics, such as invisualising a coupling or swapping operation with on-chip circuits of their own. PMID:27329510

  6. Invisibility Cloak Printed on a Photonic Chip.

    Science.gov (United States)

    Feng, Zhen; Wu, Bing-Hong; Zhao, Yu-Xi; Gao, Jun; Qiao, Lu-Feng; Yang, Ai-Lin; Lin, Xiao-Feng; Jin, Xian-Min

    2016-01-01

    Invisibility cloak capable of hiding an object can be achieved by properly manipulating electromagnetic field. Such a remarkable ability has been shown in transformation and ray optics. Alternatively, it may be realistic to create a spatial cloak by means of confining electromagnetic field in three-dimensional arrayed waveguides and introducing appropriate collective curvature surrounding an object. We realize the artificial structure in borosilicate by femtosecond laser direct writing, where we prototype up to 5,000 waveguides to conceal millimeter-scale volume. We characterize the performance of the cloak by normalized cross correlation, tomography analysis and continuous three-dimensional viewing angle scan. Our results show invisibility cloak can be achieved in waveguide optics. Furthermore, directly printed invisibility cloak on a photonic chip may enable controllable study and novel applications in classical and quantum integrated photonics, such as invisualising a coupling or swapping operation with on-chip circuits of their own. PMID:27329510

  7. A large-scale low-background liquid scintillation detector: the counting test facility at Gran Sasso

    Science.gov (United States)

    Alimonti, G.; Arpesella, C.; Bacchiocchi, G.; Balata, M.; Bellini, G.; Benziger, J.; Bonetti, S.; Brigatti, A.; Cadonati, L.; Calaprice, F. P.; Cavaletti, R.; Cecchet, G.; Chen, M.; Darnton, N.; Debari, A.; Deutsch, M.; Elisei, F.; von Feilitzsch, F.; Galbiati, C.; Garagiola, A.; Gatti, F.; Giammarchi, M. G.; Giugni, D.; Goldbrunner, T.; Golubchikov, A.; Goretti, A.; Grabar, S.; Hagner, T.; Hartmann, F.; von Hentig, R.; Heusser, G.; Ianni, A.; Jochum, J.; Johnson, M.; Laubenstein, M.; Loeser, F.; Lombardi, P.; Magni, S.; Malvezzi, S.; Manno, I.; Manuzio, G.; Masetti, F.; Mazzucato, U.; Meroni, E.; Neff, M.; Nisi, S.; Nostro, A.; Oberauer, L.; Perotti, A.; Preda, A.; Raghavan, P.; Raghavan, R. S.; Ranucci, G.; Resconi, E.; Ruscitti, P.; Scardaoni, R.; Schoenert, S.; Smirnov, O.; Tartaglia, R.; Testera, G.; Ullucci, P.; Vogelaar, R. B.; Vitale, S.; Zaimidoroga, O.

    1998-02-01

    A 4.8 m3 unsegmented liquid scintillation detector at the underground Laboratori Nazionali del Gran Sasso has shown the feasibility of multi-ton low-background detectors operating to energies as low as 250 keV. Detector construction and the handling of large volumes of liquid scintillator to minimize the background are described. The scintillator, 1.5 g PPO/L-pseudocumene, is held in a flexible nylon vessel shielded by 1000 t of purified water. The active detector volume is viewed by 100 photomultipliers, which measure time and charge for each event, from which energy, position and pulse shape are deduced. On-line purification of the scintillator by water extraction, vacuum distillation and nitrogen stripping removed radioactive impurities. Upper limits were established of thorium. The isotopic abundance of 14C/12C in the scintillator was shown to be approximately 10-18 by extending the energy window of the detector to 25-250 keV. The 14C abundance and uranium and thorium levels in the CTF are compatible with the Borexino Solar Neutrino Experiment.

  8. A large-scale low-background liquid scintillation detector: the counting test facility at Gran Sasso

    International Nuclear Information System (INIS)

    A 4.8 m3 unsegmented liquid scintillation detector at the underground Laboratori Nazionali del Gran Sasso has shown the feasibility of multi-ton low-background detectors operating to energies as low as 250 keV. Detector construction and the handling of large volumes of liquid scintillator to minimize the background are described. The scintillator, 1.5 g PPO/L-pseudocumene, is held in a flexible nylon vessel shielded by 1000 t of purified water. The active detector volume is viewed by 100 photomultipliers, which measure time and charge for each event, from which energy, position and pulse shape are deduced. On-line purification of the scintillator by water extraction, vacuum distillation and nitrogen stripping removed radioactive impurities. Upper limits were established of -7 Bq/kg-scintillator for events with energies 250 keV-9 Bq/kg-scintillator due to the decay products of uranium and thorium. The isotopic abundance of 14C/12C in the scintillator was shown to be approximately 10-18 by extending the energy window of the detector to 25-250 keV. The 14C abundance and uranium and thorium levels in the CTF are compatible with the Borexino Solar Neutrino Experiment. (orig.)

  9. Development and Deployment of a Full-Scale Cross-Flow Filtration System for Treatment of Liquid Low-Level Waste at Oak Ridge National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Kent, T.E.

    2000-05-12

    A full-scale modular solid/liquid separation (SLS) system was designed, fabricated, installed, and successfully deployed for treatment of liquid low-level waste from the Melton Valley Storage Tanks (MVSTs) at Oak Ridge National Laboratory (ORNL). The SLS module, utilizing cross-flow filtration, was operated as part of an integrated tank waste pretreatment system (otherwise known as the Wastewater Triad) to remove suspended solids and prevent fouling of ion-exchange materials and heat exchange surfaces. The information gained from this testing was used to complete design specifications for the full-scale modular SLS system in May 1997. The contract for detailed design and fabrication of the system was awarded to NUMET in July 1997, and the design was completed in January 1998. Fabrication began in March 1998, and the completed system was delivered to ORNL on December 29, 1998. Installation of the system at the MVST facility was completed in May 1999. After completing an operational readiness assessment, approval was given to commence hot operations on June 7, 1999. Operations involving two of the eight MVSTs were performed safely and with very little unscheduled downtime. Filtration of supernatant from tank W-31 was completed on June 24, 1999 and W-26 processing was completed on August 20, 1999. The total volume processed during these two campaigns was about 45,000 gal. The suspended solids content of the liquid processed from tank W-31 was lower than expected, resulting in higher-than-expected filtrate production for nearly the entire operation. The liquid processed from tank W-26 was higher in suspended solids content, and filtrate production was lower, but comparable to the rates expected based on the results of previous pilot-scale, single-element filtration tests. The quality of the filtrate consistently met the requirements for feed to the downstream ion-exchange and evaporation processes. From an equipment and controls standpoint, the modular system (pumps

  10. Development and Deployment of a Full-Scale Cross-Flow Filtration System for Treatment of Liquid Low-Level Waste at Oak Ridge National Laboratory

    International Nuclear Information System (INIS)

    A full-scale modular solid/liquid separation (SLS) system was designed, fabricated, installed, and successfully deployed for treatment of liquid low-level waste from the Melton Valley Storage Tanks (MVSTs) at Oak Ridge National Laboratory (ORNL). The SLS module, utilizing cross-flow filtration, was operated as part of an integrated tank waste pretreatment system (otherwise known as the Wastewater Triad) to remove suspended solids and prevent fouling of ion-exchange materials and heat exchange surfaces. The information gained from this testing was used to complete design specifications for the full-scale modular SLS system in May 1997. The contract for detailed design and fabrication of the system was awarded to NUMET in July 1997, and the design was completed in January 1998. Fabrication began in March 1998, and the completed system was delivered to ORNL on December 29, 1998. Installation of the system at the MVST facility was completed in May 1999. After completing an operational readiness assessment, approval was given to commence hot operations on June 7, 1999. Operations involving two of the eight MVSTs were performed safely and with very little unscheduled downtime. Filtration of supernatant from tank W-31 was completed on June 24, 1999 and W-26 processing was completed on August 20, 1999. The total volume processed during these two campaigns was about 45,000 gal. The suspended solids content of the liquid processed from tank W-31 was lower than expected, resulting in higher-than-expected filtrate production for nearly the entire operation. The liquid processed from tank W-26 was higher in suspended solids content, and filtrate production was lower, but comparable to the rates expected based on the results of previous pilot-scale, single-element filtration tests. The quality of the filtrate consistently met the requirements for feed to the downstream ion-exchange and evaporation processes. From an equipment and controls standpoint, the modular system (pumps

  11. Technology status of spray calcination--vitrification of high-level liquid waste for full-scale application

    International Nuclear Information System (INIS)

    Spray calcination and vitrification technology for stabilization of high-level nuclear wastes has been developed to the point that initiation of technology transfer to an industrial-sized facility could begin. This report discusses current process and equipment development status together with additional R and D studies and engineering evaluations needed. Preliminary full-scale process and equipment descriptions are presented. Technology application in a full-scale plant would blend three distinct maintenance design philosophies, depending on service life anticipated: (1) totally remote maintenance with limited viewing and handling equipment, (2) totally remote maintenance with extensive viewing and handling equipment, and (3) contact maintenance

  12. On-chip pretreatment of whole blood by using MEMS technology

    CERN Document Server

    Chen, Xing

    2012-01-01

    Microfabrication technology has stimulated a plurality of lab-on-a-chip research and development efforts aimed at enabling biomedical researchers and health care practitioners to manipulate and analyze complex biological fluids at the nano and microliter scale. On-chip pretreatment of whole blood is one of the hottest topics in lab-on-a-chip research since whole blood has been regarded as the most important clinical sample. Various microfluidic chips for blood sample pretreatment, such as plasma isolation, cells separation, cells lysis, gene or protein purification, etc., are described in this

  13. A one-step approach to the large-scale synthesis of functionalized MoS2 nanosheets by ionic liquid assisted grinding

    Science.gov (United States)

    Zhang, Wentao; Wang, Yanru; Zhang, Daohong; Yu, Shaoxuan; Zhu, Wenxin; Wang, Jing; Zheng, Fangqing; Wang, Shuaixing; Wang, Jianlong

    2015-05-01

    A prerequisite for exploiting most proposed applications for MoS2 is the availability of water-dispersible functionalized MoS2 nanosheets in large quantities. Here we report one-step synthesis and surface functionalization of MoS2 nanosheets by a facile ionic liquid assisted grinding method in the presence of chitosan. The selected ionic liquid with suitable surface energy could efficiently overcome the van der Waals force between the MoS2 layers. Meanwhile, chitosan molecules bind to the plane of MoS2 sheets non-covalently, which prevents the reassembling of exfoliated MoS2 sheets and facilitates the exfoliation progress. The obtained chitosan functionalized MoS2 nanosheets possess favorable stability and biocompatibility, which renders them as promising and biocompatible near-infrared agents for photothermal ablation of cancer. This contribution provides a facile way for the green, one-step and large-scale synthesis of advanced functional MoS2 materials.A prerequisite for exploiting most proposed applications for MoS2 is the availability of water-dispersible functionalized MoS2 nanosheets in large quantities. Here we report one-step synthesis and surface functionalization of MoS2 nanosheets by a facile ionic liquid assisted grinding method in the presence of chitosan. The selected ionic liquid with suitable surface energy could efficiently overcome the van der Waals force between the MoS2 layers. Meanwhile, chitosan molecules bind to the plane of MoS2 sheets non-covalently, which prevents the reassembling of exfoliated MoS2 sheets and facilitates the exfoliation progress. The obtained chitosan functionalized MoS2 nanosheets possess favorable stability and biocompatibility, which renders them as promising and biocompatible near-infrared agents for photothermal ablation of cancer. This contribution provides a facile way for the green, one-step and large-scale synthesis of advanced functional MoS2 materials. Electronic supplementary information (ESI) available: The

  14. Various On-Chip Sensors with Microfluidics for Biological Applications

    Directory of Open Access Journals (Sweden)

    Hun Lee

    2014-09-01

    Full Text Available In this paper, we review recent advances in on-chip sensors integrated with microfluidics for biological applications. Since the 1990s, much research has concentrated on developing a sensing system using optical phenomena such as surface plasmon resonance (SPR and surface-enhanced Raman scattering (SERS to improve the sensitivity of the device. The sensing performance can be significantly enhanced with the use of microfluidic chips to provide effective liquid manipulation and greater flexibility. We describe an optical image sensor with a simpler platform for better performance over a larger field of view (FOV and greater depth of field (DOF. As a new trend, we review consumer electronics such as smart phones, tablets, Google glasses, etc. which are being incorporated in point-of-care (POC testing systems. In addition, we discuss in detail the current optical sensing system integrated with a microfluidic chip.

  15. Dental Care for Medicaid and CHIP Enrollees

    Science.gov (United States)

    ... Amendments Dental Care Dental Care for Medicaid and CHIP Enrollees Dental health is an important part of ... for dental services. Dental Benefits for Children in CHIP States that provide CHIP coverage to children through ...

  16. A hybrid molecular dynamics/fluctuating hydrodynamics method for modelling liquids at multiple scales in space and time

    International Nuclear Information System (INIS)

    A new 3D implementation of a hybrid model based on the analogy with two-phase hydrodynamics has been developed for the simulation of liquids at microscale. The idea of the method is to smoothly combine the atomistic description in the molecular dynamics zone with the Landau-Lifshitz fluctuating hydrodynamics representation in the rest of the system in the framework of macroscopic conservation laws through the use of a single “zoom-in” user-defined function s that has the meaning of a partial concentration in the two-phase analogy model. In comparison with our previous works, the implementation has been extended to full 3D simulations for a range of atomistic models in GROMACS from argon to water in equilibrium conditions with a constant or a spatially variable function s. Preliminary results of simulating the diffusion of a small peptide in water are also reported

  17. III-Vs at Scale: A PV Manufacturing Cost Analysis of the Thin Film Vapor-Liquid-Solid Growth Mode

    Energy Technology Data Exchange (ETDEWEB)

    Zheng, Maxwell; Horowitz, Kelsey; Woodhouse, Michael; Battaglia, Corsin; Kapadia, Rehan; Javey, Ali

    2016-06-01

    The authors present a manufacturing cost analysis for producing thin-film indium phosphide modules by combining a novel thin-film vapor-liquid-solid (TF-VLS) growth process with a standard monolithic module platform. The example cell structure is ITO/n-TiO2/p-InP/Mo. For a benchmark scenario of 12% efficient modules, the module cost is estimated to be $0.66/W(DC) and the module cost is calculated to be around $0.36/W(DC) at a long-term potential efficiency of 24%. The manufacturing cost for the TF-VLS growth portion is estimated to be ~$23/m2, a significant reduction compared with traditional metalorganic chemical vapor deposition. The analysis here suggests the TF-VLS growth mode could enable lower-cost, high-efficiency III-V photovoltaics compared with manufacturing methods used today and open up possibilities for other optoelectronic applications as well.

  18. A hybrid molecular dynamics/fluctuating hydrodynamics method for modelling liquids at multiple scales in space and time

    Energy Technology Data Exchange (ETDEWEB)

    Korotkin, Ivan, E-mail: i.korotkin@qmul.ac.uk; Karabasov, Sergey; Markesteijn, Anton [The School of Engineering and Material Science, Queen Mary University of London, Mile End Road, E1 4NS London (United Kingdom); Nerukh, Dmitry; Scukins, Arturs [Institute of Systems Analytics, Aston University, Birmingham B4 7ET (United Kingdom); Farafonov, Vladimir [Department of Physical Chemistry, V. N. Karazin Kharkiv National University, Svobody Square 4, 61022 Kharkiv (Ukraine); Pavlov, Evgen [Institute of Systems Analytics, Aston University, Birmingham B4 7ET (United Kingdom); Faculty of Physics, Kiev National Taras Shevchenko University, Prospect Acad. Glushkova 4, Kiev 03127 (Ukraine)

    2015-07-07

    A new 3D implementation of a hybrid model based on the analogy with two-phase hydrodynamics has been developed for the simulation of liquids at microscale. The idea of the method is to smoothly combine the atomistic description in the molecular dynamics zone with the Landau-Lifshitz fluctuating hydrodynamics representation in the rest of the system in the framework of macroscopic conservation laws through the use of a single “zoom-in” user-defined function s that has the meaning of a partial concentration in the two-phase analogy model. In comparison with our previous works, the implementation has been extended to full 3D simulations for a range of atomistic models in GROMACS from argon to water in equilibrium conditions with a constant or a spatially variable function s. Preliminary results of simulating the diffusion of a small peptide in water are also reported.

  19. Rapid prototyping of microfluidic chips for dead-volume-free MS coupling.

    Science.gov (United States)

    Dietze, Claudia; Scholl, Tobias; Ohla, Stefan; Appun, Johannes; Schneider, Christoph; Belder, Detlev

    2015-11-01

    A fast and straightforward method to prototype microfluidic chip systems for dead-volume-free hyphenation to electrospray-ionisation mass spectrometry is presented. The developed approach based on liquid-phase lithography provides an inexpensive and reliable access to microfluidic chips for MS coupling which can be manufactured in any laboratory with low technical demands. The rapid prototyping approach enables the seamless integration of capillaries serving as electrospray emitters with negligible dead volume. The high versatility of the presented prototyping method and the applicability of a variety of chip-based devices in different fields of lab-on-a-chip technology are established for analytical separations by means of chip-electrochromatography-MS and for continuous-flow synthesis using microreactor technology with MS detection. PMID:26391402

  20. Determination of Landau Fermi-liquid parameters of strongly interacting fermions by means of a nonlinear scaling transformation

    OpenAIRE

    Chen, Ji-sheng

    2008-01-01

    A nonlinear transformation approach is formulated for the correlated fermions' thermodynamics through a medium-scaling effective action. An auxiliary implicit variable-effective chemical potential is introduced to characterize the non-Gaussian fluctuations physics. By incorporating the nonlocal correlation effects, the achieved grand partition function is made of coupled highly nonlinear parametric equations. Analytically, the low temperature expansions for the strongly interacting unitary Fe...

  1. Milking liquid nano-droplets by an IR laser: a new modality for the visualization of electric field lines

    International Nuclear Information System (INIS)

    Liquid handling at micron- and nano-scale is of paramount importance in many fields of application such as biotechnology and biochemistry. In fact, the microfluidics technologies play an important role in lab-on-a-chip devices and, in particular, the dispensing of liquid droplets is a required functionality. Different approaches have been developed for manipulating, dispensing and controlling nano-droplets under a wide variety of configurations. Here we demonstrate that nano-droplets can be drawn from liquid drop or film reservoirs through a sort of milking effect achieved by the absorption of IR laser radiation into a pyroelectric crystal. The generation of the pyroelectric field induced by the IR laser is calculated numerically and a specific experiment has been designed to visualize the electric field stream lines that are responsible for the liquid milking effect. The experiments performed are expected to open a new route for the visualization, measure and characterization procedures in the case of electrohydrodynamic applications. (paper)

  2. Impact of ultrasound on solid-liquid extraction of phenolic compounds from maritime pine sawdust waste. Kinetics, optimization and large scale experiments.

    Science.gov (United States)

    Meullemiestre, A; Petitcolas, E; Maache-Rezzoug, Z; Chemat, F; Rezzoug, S A

    2016-01-01

    Maritime pine sawdust, a by-product from industry of wood transformation, has been investigated as a potential source of polyphenols which were extracted by ultrasound-assisted maceration (UAM). UAM was optimized for enhancing extraction efficiency of polyphenols and reducing time-consuming. In a first time, a preliminary study was carried out to optimize the solid/liquid ratio (6g of dry material per mL) and the particle size (0.26 cm(2)) by conventional maceration (CVM). Under these conditions, the optimum conditions for polyphenols extraction by UAM, obtained by response surface methodology, were 0.67 W/cm(2) for the ultrasonic intensity (UI), 40°C for the processing temperature (T) and 43 min for the sonication time (t). UAM was compared with CVM, the results showed that the quantity of polyphenols was improved by 40% (342.4 and 233.5mg of catechin equivalent per 100g of dry basis, respectively for UAM and CVM). A multistage cross-current extraction procedure allowed evaluating the real impact of UAM on the solid-liquid extraction enhancement. The potential industrialization of this procedure was implemented through a transition from a lab sonicated reactor (3 L) to a large scale one with 30 L volume. PMID:26384903

  3. Full-Scale Testing Technology Maturation Of A Thin Film Evaporator For High-Level Liquid Waste Management At Hanford - 12125

    International Nuclear Information System (INIS)

    Simulant testing of a full-scale thin-film evaporator system was conducted in 2011 for technology development at the Hanford tank farms. Test results met objectives of water removal rate, effluent quality, and operational evaluation. Dilute tank waste simulant, representing a typical double-shell tank supernatant liquid layer, was concentrated from a 1.1 specific gravity to approximately 1.5 using a 4.6 m2 (50 ft2) heated transfer area Rototherm(regsign) evaporator from Artisan Industries. The condensed evaporator vapor stream was collected and sampled validating efficient separation of the water. An overall decontamination factor of 1.2E+06 was achieved demonstrating excellent retention of key radioactive species within the concentrated liquid stream. The evaporator system was supported by a modular steam supply, chiller, and control computer systems which would be typically implemented at the tank farms. Operation of these support systems demonstrated successful integration while identifying areas for efficiency improvement. Overall testing effort increased the maturation of this technology to support final deployment design and continued project implementation.

  4. Pilot-Scale Test Results Of A Thin Film Evaporator System For Management Of Liquid High-Level Wastes At The Hanford Site Washington USA -11364

    International Nuclear Information System (INIS)

    A modular, transportable evaporator system, using thin film evaporative technology, is planned for deployment at the Hanford radioactive waste storage tank complex. This technology, herein referred to as a wiped film evaporator (WFE), will be located at grade level above an underground storage tank to receive pumped liquids, concentrate the liquid stream from 1.1 specific gravity to approximately 1.4 and then return the concentrated solution back into the tank. Water is removed by evaporation at an internal heated drum surface exposed to high vacuum. The condensed water stream will be shipped to the site effluent treatment facility for final disposal. This operation provides significant risk mitigation to failure of the aging 242-A Evaporator facility; the only operating evaporative system at Hanford maximizing waste storage. This technology is being implemented through a development and deployment project by the tank farm operating contractor, Washington River Protection Solutions (WRPS), for the Office of River Protection/Department of Energy (ORPIDOE), through Columbia Energy and Environmental Services, Inc. (Columbia Energy). The project will finalize technology maturity and install a system at one of the double-shell tank farms. This paper summarizes results of a pilot-scale test program conducted during calendar year 2010 as part of the ongoing technology maturation development scope for the WFE.

  5. Pilot-scale experience with biological nutrient removal and biomass yield reduction in a liquid-solid circulating fluidized bed bioreactor.

    Science.gov (United States)

    Chowdhury, Nabin; Nakhla, George; Zhu, Jesse; Islam, Mohammad

    2010-01-01

    A pilot-scale liquid-solid circulating fluidized bed (LSCFB) bioreactor was developed at the Adelaide Pollution Control Plant, London, Ontario, Canada, to study its commercial viability for biological nutrient removal. Lava rock particles of 600 microm were used as a biomass carrier media. The LSCFB removed approximately 90% organic, 80% nitrogen, and 70% phosphorus at loading rates of 4.12 kg COD/m3 x d, 0.26 kg N/m3 x d, and 0.052 kg P/m3 x d, and an empty bed contact time of 1.5 hours. Effluent characterized by clarifier removed suspended solids removal without chemicals. A significant reduction (approximately 75%) in biomass yield to 0.12 to 0.16 g VSS/g chemical oxygen demand (COD) was observed, primarily because of long biological solids retention time (SRT) of 20 to 39 days and a combination of anoxic and aerobic COD consumption. PMID:20942332

  6. Self-assembly of highly fluorescent semiconductor nanorods into large scale smectic liquid crystal structures by coffee stain evaporation dynamics

    International Nuclear Information System (INIS)

    We deposit droplets of nanorods dispersed in solvents on substrate surfaces and let the solvent evaporate. We find that strong contact line pinning leads to dense nanorod deposition inside coffee stain fringes, where we observe large scale lateral ordering of the nanorods with the long axis of the rods oriented parallel to the contact line. We observe birefringence of these coffee stain fringes by polarized microscopy and we find the direction of the extraordinary refractive index parallel to the long axis of the nanorods.

  7. Self-assembly of highly fluorescent semiconductor nanorods into large scale smectic liquid crystal structures by coffee stain evaporation dynamics

    Energy Technology Data Exchange (ETDEWEB)

    Nobile, Concetta; Carbone, Luigi; Fiore, Angela; Cingolani, Roberto; Manna, Liberato; Krahne, Roman [National Nanotechnology Laboratory of CNR-INFM, Via Arnesano, 73100 Lecce (Italy)], E-mail: roman.krahne@unile.it

    2009-07-01

    We deposit droplets of nanorods dispersed in solvents on substrate surfaces and let the solvent evaporate. We find that strong contact line pinning leads to dense nanorod deposition inside coffee stain fringes, where we observe large scale lateral ordering of the nanorods with the long axis of the rods oriented parallel to the contact line. We observe birefringence of these coffee stain fringes by polarized microscopy and we find the direction of the extraordinary refractive index parallel to the long axis of the nanorods.

  8. Novel approach for extinguishing large-scale coal fires using gas-liquid foams in open pit mines.

    Science.gov (United States)

    Lu, Xinxiao; Wang, Deming; Qin, Botao; Tian, Fuchao; Shi, Guangyi; Dong, Shuaijun

    2015-12-01

    Coal fires are a serious threat to the workers' security and safe production in open pit mines. The coal fire source is hidden and innumerable, and the large-area cavity is prevalent in the coal seam after the coal burned, causing the conventional extinguishment technology difficult to work. Foams are considered as an efficient means of fire extinguishment in these large-scale workplaces. A noble foam preparation method is introduced, and an original design of cavitation jet device is proposed to add foaming agent stably. The jet cavitation occurs when the water flow rate and pressure ratio reach specified values. Through self-building foaming system, the high performance foams are produced and then infused into the blast drilling holes at a large flow. Without complicated operation, this system is found to be very suitable for extinguishing large-scale coal fires. Field application shows that foam generation adopting the proposed key technology makes a good fire extinguishment effect. The temperature reduction using foams is 6-7 times higher than water, and CO concentration is reduced from 9.43 to 0.092‰ in the drilling hole. The coal fires are controlled successfully in open pit mines, ensuring the normal production as well as the security of personnel and equipment. PMID:26370817

  9. Silicon integrated nanophotonics for on-chip interconnects

    Science.gov (United States)

    Vlasov, Yurii

    2008-03-01

    Current trend in microelectronics industry is to increase the parallelism in computation by multi-threading, by building large scale multi-chip systems and, more recently, by increasing the number of cores on a single chip. With such increase of parallelization the interconnect bandwidth between the racks, chips or different cores is becoming a limiting factor for the design of high performance computer systems. The on-chip ultrahigh-bandwidth silicon-based photonic network might provide an attractive solution to this bandwidth bottleneck. We will review recent results on silicon nanophotonic circuits based on photonic wires and photonic crystals. Strong light confinement at the diffraction limit enables dramatic scaling of the device area and allows unprecedented control over optical signals. Silicon nanophotonic devices have immense capacity for low-loss, high-bandwidth data processing that might enable the design of ultra-compact on-chip optical networks. In particular we will show recent results on design and characterization of various ultra-compact (circuits as optical delay lines, electro-optic modulators, broadband optical switches, wavelength filters, etc.

  10. Liquids and liquid mixtures

    CERN Document Server

    Rowlinson, J S; Baldwin, J E; Buckingham, A D; Danishefsky, S

    2013-01-01

    Liquids and Liquid Mixtures, Third Edition explores the equilibrium properties of liquids and liquid mixtures and relates them to the properties of the constituent molecules using the methods of statistical thermodynamics. Topics covered include the critical state, fluid mixtures at high pressures, and the statistical thermodynamics of fluids and mixtures. This book consists of eight chapters and begins with an overview of the liquid state and the thermodynamic properties of liquids and liquid mixtures, including vapor pressure and heat capacities. The discussion then turns to the thermodynami

  11. Optimization of Large-Scale Culture Conditions for the Production of Cordycepin with Cordyceps militaris by Liquid Static Culture

    Directory of Open Access Journals (Sweden)

    Chao Kang

    2014-01-01

    Full Text Available Cordycepin is one of the most important bioactive compounds produced by species of Cordyceps sensu lato, but it is hard to produce large amounts of this substance in industrial production. In this work, single factor design, Plackett-Burman design, and central composite design were employed to establish the key factors and identify optimal culture conditions which improved cordycepin production. Using these culture conditions, a maximum production of cordycepin was 2008.48 mg/L for 700 mL working volume in the 1000 mL glass jars and total content of cordycepin reached 1405.94 mg/bottle. This method provides an effective way for increasing the cordycepin production at a large scale. The strategies used in this study could have a wide application in other fermentation processes.

  12. Liquid Core ARROW Waveguides: A Promising Photonic Structure for Integrated Optofluidic Microsensors

    Directory of Open Access Journals (Sweden)

    Genni Testa

    2016-03-01

    Full Text Available In this paper, we introduce a liquid core antiresonant reflecting optical waveguide (ARROW as a novel optofluidic device that can be used to create innovative and highly functional microsensors. Liquid core ARROWs, with their dual ability to guide the light and the fluids in the same microchannel, have shown great potential as an optofluidic tool for quantitative spectroscopic analysis. ARROWs feature a planar architecture and, hence, are particularly attractive for chip scale integrated system. Step by step, several improvements have been made in recent years towards the implementation of these waveguides in a complete on-chip system for highly-sensitive detection down to the single molecule level. We review applications of liquid ARROWs for fluids sensing and discuss recent results and trends in the developments and applications of liquid ARROW in biomedical and biochemical research. The results outlined show that the strong light matter interaction occurring in the optofluidic channel of an ARROW and the versatility offered by the fabrication methods makes these waveguides a very promising building block for optofluidic sensor development.

  13. Chips with everything

    CERN Document Server

    CERN. Geneva

    2007-01-01

    In March 1972, Sir Robin Saxby gave a talk to the Royal Television Society called 'TV and Chips' about a 'state of the art' integrated circuit, containing 50 resistors and 50 transistors. Today's 'state of the art' chips contain up to a billion transistors. This enormous leap forward illustrates how dramatically the semiconductor industry has evolved in the past 34 years. The next 10 years are predicted to bring times of turbulent change for the industry, as more and more digital devices are used around the world. In this talk, Sir Robin will discuss the history of the Microchip Industry in parallel with ARM's history, demonstrating how a small European start-up can become a world player in the IT sector. He will also present his vision of important applications and developments in the next 20 years that are likely to become even more pervasive than the mobile phone is today, and will provide anecdotes and learning points from his own experience at ARM. About ARM: Sir Robin and a group of designers from Acorn...

  14. Patterning liquids on inkjet-imprinted surfaces with highly adhesive superhydrophobicity

    Science.gov (United States)

    Bao, Bin; Sun, Jiazhen; Gao, Meng; Zhang, Xingye; Jiang, Lei; Song, Yanlin

    2016-05-01

    The rapidly increasing research interest in microfluidics, microreactors and solution-processable fabrication technologies requires the development of patterning techniques to obtain large-scale functional liquid arrays. To achieve this objective, photolithography, microcontact printing and mask-based UV irradiation have been utilized to physically or chemically pattern surfaces into templates where ordered arrays of liquid materials are constructed. However, these methods require elaborately fabricated templates or expensive vacuum-deposited masks that restrict their practical applications. Herein, we fabricate physically patterned superhydrophobic surfaces with high adhesion by modifying inkjet-imprinted surfaces through nanoparticle deposition, and utilize these surfaces as templates for liquid patterning. Various functional liquid materials are patterned into defined shapes through a simple dipping-withdrawing process. Moreover, functional material patterns such as photonic crystal patterns, arrays of inorganic nanoparticles and crystals are formed after solvent evaporation of the liquid droplets. Furthermore, chemical reactions can be carried out on the patterns. These surfaces demonstrate excellent performance in liquid patterning, which will find numerous applications in optoelectronic devices, lab-on-chip devices, microreactors, and related fields.The rapidly increasing research interest in microfluidics, microreactors and solution-processable fabrication technologies requires the development of patterning techniques to obtain large-scale functional liquid arrays. To achieve this objective, photolithography, microcontact printing and mask-based UV irradiation have been utilized to physically or chemically pattern surfaces into templates where ordered arrays of liquid materials are constructed. However, these methods require elaborately fabricated templates or expensive vacuum-deposited masks that restrict their practical applications. Herein, we fabricate

  15. Lab-on-a-Chip Systems for Microchemical Applications

    Directory of Open Access Journals (Sweden)

    Dong-Pyo Kim

    2011-12-01

    Full Text Available Lab-on-a-chip microchemical systems were fabricated from PDMS, polyimide (PI film and functional polymers by different lithographic techniques to look for microreactor applications in the areas of organic syntheses. In detail, efficient gas-liquid reactions in dual-channel microreactor, continuous recovery and recirculation of catalystimmobilized magnetic particles in microfluidic system, and a flexible film microreactor will be discussed.

  16. Designing a WISHBONE Protocol Network Adapter for an Asynchronous Network-on-Chip

    OpenAIRE

    Soliman, Ahmed H. M.; E. M.Saad; M El Bably; Keshk, Hesham M. A. M.

    2012-01-01

    The Scaling of microchip technologies, from micron to submicron and now to deep sub-micron (DSM) range, has enabled large scale systems-on-chip (SoC). In future deep submicron (DSM) designs, the interconnect effect will definitely dominate performance. Network-on-Chip (NoC) has become a promising solution to bus-based communication infrastructure limitations. NoC designs usually targets Application Specific Integrated Circuits (ASICs), however, the fabrication process costs a lot. Implementin...

  17. Wood chips procurement and research project at the Mikkeli region; Puuhakkeen hankinta- ja tutkimusprojekti Mikkelin seudulla

    Energy Technology Data Exchange (ETDEWEB)

    Saksa, T. [Finnish Forest Research Inst., Suonenjoki (Finland). Suonenjoki Research Station; Auvinen, P. [Mikkeli city (Finland). Dept. of Agriculture and Forestry

    1996-12-31

    In 1993-94, a large-scale energywood production chain started as a co-operation project by the Mikkeli city forest office and local forestry societies. In 1995 over 115 000 m{sup 3} (about 85 000 MWh of energy) of wood chips were delivered to Pursiala heat and power plant in Mikkeli. About 75 % of these chips was forest processed chips. About 70 % of the forest processed chips was whole tree chips from improvement cuttings of young forest stands and the rest was logging waste chips from regeneration cutting areas. The average total delivery costs of forest processed chips after reduction of energywood and other subsidies were approximately 45 FIM/m{sup 3} (60 FIM/MWh) for the whole tree chips and 38 FIM/m{sup 3} (50 FIM/MWh) for logging waste chips. The delivery costs of forest processed chips could meet the target of Bioenergy Research Programme (45 FIM/MWh) only in the most favourable cases. In an average the delivery costs were about 9 FIM/MWh more than the price obtained when sold to the heat and power plant. However the wood chip production created 27 new jobs and the increase of income to the local economy was about 2.2 milj. FIM /year. The local communities got new tax revenue about 3 FIM/MWh. The gain for the forestry was approximated to be 5 - 6 FIM/MWh. The resources of forest processed chips were studied on the basis of stand measurements. According to the study the most remarkable energywood resources were in young thinning stands on Oxalis-Myrtillus and Myrtillus forest site types. On Oxalis-Myrtillus type almost every and on Myrtillus type every second stand included energywood more than 40 m{sup 3}/ha

  18. Resolving Non-Specific and Specific Adhesive Interactions of Catechols at Solid/Liquid Interfaces at the Molecular Scale.

    Science.gov (United States)

    Utzig, Thomas; Stock, Philipp; Valtiner, Markus

    2016-08-01

    The adhesive system of mussels evolved into a powerful and adaptive system with affinity to a wide range of surfaces. It is widely known that thereby 3,4-dihydroxyphenylalanine (Dopa) plays a central role. However underlying binding energies remain unknown at the single molecular scale. Here, we use single-molecule force spectroscopy to estimate binding energies of single catechols with a large range of opposing chemical functionalities. Our data demonstrate significant interactions of Dopa with all functionalities, yet most interactions fall within the medium-strong range of 10-20 kB T. Only bidentate binding to TiO2 surfaces exhibits a higher binding energy of 29 kB T. Our data also demonstrate at the single-molecule level that oxidized Dopa and amines exhibit interaction energies in the range of covalent bonds, confirming the important role of Dopa for cross-linking in the bulk mussel adhesive. We anticipate that our approach and data will further advance the understanding of biologic and technologic adhesives. PMID:27374053

  19. Ultra-thin chip technology and applications

    CERN Document Server

    2010-01-01

    Ultra-thin chips are the "smart skin" of a conventional silicon chip. This book shows how very thin and flexible chips can be fabricated and used in many new applications in microelectronics, microsystems, biomedical and other fields. It provides a comprehensive reference to the fabrication technology, post processing, characterization and the applications of ultra-thin chips.

  20. Nonequilibrium dynamics, Optimal Control and Nanofibers on an Atom Chip

    International Nuclear Information System (INIS)

    Full text: We present experiments on dynamical scaling of many-particle states, performed on degenerate 87Rb Bose gases in a time dependent trapping potential. A stochastic optimal control scheme has been implemented to manipulate the motional dynamics of such clouds, with prospects to engineer specific nonequilibrium states. Further, we present a novel atom - photon interface based on integrating optical nanofibers and nanofiber - cavities on an atom chip. Applications encompass light storage and nonlinear interactions between photons within the device, facilitated by the high optical densities and low temperatures of ultracold atom clouds in a chip trap, as well as the high transmission of an optical nanofiber. (author)

  1. On-chip photonic interconnects a computer architect's perspective

    CERN Document Server

    Nitta, Christopher J; Akella, Venkatesh

    2013-01-01

    As the number of cores on a chip continues to climb, architects will need to address both bandwidth and power consumption issues related to the interconnection network. Electrical interconnects are not likely to scale well to a large number of processors for energy efficiency reasons, and the problem is compounded by the fact that there is a fixed total power budget for a die, dictated by the amount of heat that can be dissipated without special (and expensive) cooling and packaging techniques. Thus, there is a need to seek alternatives to electrical signaling for on-chip interconnection appli

  2. New circuit switching techniques in on-chip networks

    OpenAIRE

    Shaoteng, Liu

    2015-01-01

    Network on Chip (NoC) is proposed as a promising technology to address the communication challenges in deep sub-micron era. NoC brings network-based communication into the on-chip environment and tackles the problems like long wire complexities, bandwidth scaling and so on. After more than a decade's evolution and development, there are many NoC architectures and solutions available. Nevertheless, NoCs can be classi_ed into two categories: packet switched NoC and circuit switched NoC. In this...

  3. Proteomic analysis of prolactinoma cells by immuno-laser capture microdissection combined with online two-dimensional nano-scale liquid chromatography/mass spectrometry

    Directory of Open Access Journals (Sweden)

    Chen Luping

    2010-01-01

    Full Text Available Abstract Background Pituitary adenomas, the third most common intracranial tumor, comprise nearly 16.7% of intracranial neoplasm and 25%-44% of pituitary adenomas are prolactinomas. Prolactinoma represents a complex heterogeneous mixture of cells including prolactin (PRL, endothelial cells, fibroblasts, and other stromal cells, making it difficult to dissect the molecular and cellular mechanisms of prolactin cells in pituitary tumorigenesis through high-throughout-omics analysis. Our newly developed immuno-laser capture microdissection (LCM method would permit rapid and reliable procurement of prolactin cells from this heterogeneous tissue. Thus, prolactin cell specific molecular events involved in pituitary tumorigenesis and cell signaling can be approached by proteomic analysis. Results Proteins from immuno-LCM captured prolactin cells were digested; resulting peptides were separated by two dimensional-nanoscale liquid chromatography (2D-nanoLC/MS and characterized by tandem mass spectrometry. All MS/MS spectrums were analyzed by SEQUEST against the human International Protein Index database and a specific prolactinoma proteome consisting of 2243 proteins was identified. This collection of identified proteins by far represents the largest and the most comprehensive database of proteome for prolactinoma. Category analysis of the proteome revealed a widely unbiased access to various proteins with diverse functional characteristics. Conclusions This manuscript described a more comprehensive proteomic profile of prolactinomas compared to other previous published reports. Thanks to the application of immuno-LCM combined with online two-dimensional nano-scale liquid chromatography here permitted identification of more proteins and, to our best knowledge, generated the largest prolactinoma proteome. This enlarged proteome would contribute significantly to further understanding of prolactinoma tumorigenesis which is crucial to the management of

  4. Commercial-scale demonstration of the Liquid Phase Methanol (LPMEOH{trademark}) process. Environmental monitoring report No. 1, 1 April 1997--31 June 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-02-13

    The Liquid Phase Methanol (LPMEOH{trademark}) demonstration project at Kingsport, Tennessee, is a $213.7 million cooperative agreement between the U.S. Department of Energy (DOE) and Air Products Liquid Phase Conversion Company, L.P. (the Partnership). Air Products and Chemicals, Inc. (Air Products) and Eastman Chemical Company (Eastman) formed the Partnership to execute the Demonstration Project. A demonstration unit producing 80,000 gallons per day (260 TPD) of methanol was designed, constructed, and has begun operation at a site located at the Eastman complex in Kingsport. The Partnership will own and operate the facility for the four-year demonstration period. This project is sponsored under the DOE`s Clean Coal Technology Program, and its primary objective is to {open_quotes}demonstrate the production of methanol using the LPMEOH{trademark} Processing conjunction with an integrated coal gasification facility.{close_quotes} The project will also demonstrate the suitability of the methanol produced for use as a chemical feedstock or as a low-sulfur dioxide, low-nitrogen oxides alternative fuel in stationary and transportation applications. The project may also demonstrate the production of dimethyl ether (DME) as a mixed coproduct with methanol, if laboratory- and pilot-scale research and market verification studies show promising results. If implemented, the DME would be produced during the last six months of the four-year demonstration period. The LPMEOH{trademark} process is the product of a cooperative development effort by Air Products and the DOE in a program that started in 1981. It was successfully piloted at a 10-TPD rate in the DOE-owned experimental unit at Air Products` LaPorte, Texas, site. This demonstration project is the culmination of that extensive cooperative development effort.

  5. Materials for microfluidic chip fabrication.

    Science.gov (United States)

    Ren, Kangning; Zhou, Jianhua; Wu, Hongkai

    2013-11-19

    Through manipulating fluids using microfabricated channel and chamber structures, microfluidics is a powerful tool to realize high sensitive, high speed, high throughput, and low cost analysis. In addition, the method can establish a well-controlled microenivroment for manipulating fluids and particles. It also has rapid growing implementations in both sophisticated chemical/biological analysis and low-cost point-of-care assays. Some unique phenomena emerge at the micrometer scale. For example, reactions are completed in a shorter amount of time as the travel distances of mass and heat are relatively small; the flows are usually laminar; and the capillary effect becomes dominant owing to large surface-to-volume ratios. In the meantime, the surface properties of the device material are greatly amplified, which can lead to either unique functions or problems that we would not encounter at the macroscale. Also, each material inherently corresponds with specific microfabrication strategies and certain native properties of the device. Therefore, the material for making the device plays a dominating role in microfluidic technologies. In this Account, we address the evolution of materials used for fabricating microfluidic chips, and discuss the application-oriented pros and cons of different materials. This Account generally follows the order of the materials introduced to microfluidics. Glass and silicon, the first generation microfluidic device materials, are perfect for capillary electrophoresis and solvent-involved applications but expensive for microfabriaction. Elastomers enable low-cost rapid prototyping and high density integration of valves on chip, allowing complicated and parallel fluid manipulation and in-channel cell culture. Plastics, as competitive alternatives to elastomers, are also rapid and inexpensive to microfabricate. Their broad variety provides flexible choices for different needs. For example, some thermosets support in-situ fabrication of

  6. Ceramic packages for liquid-nitrogen operation

    International Nuclear Information System (INIS)

    To evaluate their compatibility for use in a liquid-nitrogen computer, metallized ceramic packages with test chips joined using IBM controlled-collapse solder (Pb-Sn) technology have been cycled between 300C and liquid-nitrogen temperature. Room-temperature electrical resistance measurements were made at regular intervals of cycles to determine whether solder failure accompanied by a significant resistance increase had occurred. For the failed solder joints characterized by the highest thermal shear strain amplitude of 3.3 percent, the authors were able to estimate the number of liquid-nitrogen cycles needed to produce the corresponding failure rate using a room-temperature solder lifetime model. Cross-sectional examination of the failed solder joints using scanning electron microscopy and energy dispersive X-ray analysis indicated solder cracking occurring at the solder-ceramic interface. Chip pull tests on cycled packages yielded strengths far exceeding the minimal requirement. Mechanisms involving the formation of intermetallics were proposed to account for the observed solder fracture modes after liquid-nitrogen cycling and after chip pull. Furthermore, scanning electron microscopic examination of pulled chips in cycled packages showed no apparent sign of cracking in quartz and polyimide for chip insulation

  7. CRRES microelectronic test chip

    International Nuclear Information System (INIS)

    This paper reports on the JPL CRRES chip which was designed and fabricated in 1985 and included in the CRRES MEP. MOSFET Matrix results show the effect of shielding on radiation-induced MOSFET threshold voltage shifts and channel mobility degradation. Shielded (middle board) MOSFETs have a threshold-voltage damage factor that is approximately three-orders of magnitude smaller than would be estimated from Co-60 ground tests. Temperature swings as large as 23 degrees C with a 22.5 orbit periodicity affected the MOSFET data and was removed from the data in order to reveal the radiation effects. This experiment demonstrated the feasibility of characterizing MOSFETs in a matrix thus reducing the complexity and mass of the experiment

  8. Fermions and bosons on an atom chip

    Science.gov (United States)

    Extravour, Marcius H. T.

    Ultra-cold dilute gases of neutral atoms are attractive candidates for creating controlled mesoscopic quantum systems. In particular, quantum degenerate gases of bosonic and fermionic atoms can be used to model the correlated many-body behaviour of Bose and Fermi condensed matter systems, and to study matter wave interference and coherence. This thesis describes the experimental realization and manipulation of Bose-Einstein condensates (BECs) of 87Rb and degenerate Fermi gases (DFGs) of 40K using static and dynamic magnetic atom chip traps. Atom chips are versatile modern tools used to manipulate atomic gases. The chips consist of micrometre-scale conductors supported by a planar insulating substrate, and can be used to create confining potentials for neutral atoms tens or hundreds of micrometres from the chip surface. We demonstrate for the first time that a DFG can be produced via sympathetic cooling with a BEC using a simple single-vacuum-chamber apparatus. The large 40 K-87Rb collision rate afforded by the strongly confining atom chip potential permits rapid cooling of 40K to quantum degeneracy via sympathetic cooling with 87Rb. By studying 40K-87Rb cross-thermalization as a function of temperature, we observe the Ramsauer-Townsend reduction in the 40K-87Rb elastic scattering cross-section. We achieve DFG temperatures as low as T ≈ 0:1TF, and observe Fermi pressure in the time-of-flight expansion of the gas. This thesis also describes the radio-frequency (RF) manipulation of trapped atoms to create dressed state double-well potentials for BEC and DFG. We demonstrate for the first time that RF-dressed potentials are species-selective, permitting the formation of simultaneous 87Rb double-well and 40K single-well potentials using a 40K-87Rb mixture. We also develop tools to measure fluctuations of the relative atom number and relative phase of a dynamically split 87Rb BEC. In particular, we observe atom number fluctuations at the shot-noise level using time

  9. Avaliação da aceitação de "chips" de mandioca Acceptance evaluation of cassava chips

    Directory of Open Access Journals (Sweden)

    Regina Kitagawa Grizotto

    2003-12-01

    Full Text Available Pré-tratamentos como o cozimento, a fermentação natural e a secagem parcial foram aplicados em raízes de mandioca, visando a obtenção de "chips" comestíveis. A avaliação sensorial foi feita com base na aceitação e aparência dos "chips" das variedades IAC Mantiqueira e IAC 576.70. Trinta consumidores potenciais do produto foram selecionados em função da disponibilidade e interesse em participar dos testes. Foi utilizada escala hedônica de 7 pontos, onde os provadores avaliaram as amostras delineadas em blocos casualizados. Os resultados obtidos mostraram que os "chips" controle e pré-cozidos foram aceitos sensorialmente, apresentado médias de 5,1 (gostei ligeiramente para IAC Mantiqueira e 6,0 (gostei moderadamente para IAC 576.70. Os "chips" pré-fermentados de ambas variedades foram rejeitados. Os termos de agrado mais comentados pelos provadores foram "sabor de mandioca", "crocância" e "textura". Os termos de desagrado mais citados incluem "textura dura", "falta sabor de mandioca" e "gosto de óleo". Os provadores consideraram adequada a aparência dos "chips" de ambas variedades, sendo ligeiramente preferida a aparência dos "chips" da IAC 576.70, com exceção dos "chips" cozidos por 8 minutos e os fermentados, rejeitados pelos consumidores. A cor amarela da polpa pode ter influenciado a aceitação da variedade IAC 576.70. A composição centesimal e o teor de fibras na mandioca in natura e, o teor de lipídeos em "chips" de mandioca, também foram apresentados.Pre-treatments such as cooking, natural fermentation and partial drying were applied to cassava roots, aimed at obtaining edible cassava chips. The sensory evaluation was based on the acceptance and appearance of the chips, using the varieties IAC Mantiqueira and IAC 576.70. Thirty potential consumers of the product were selected based on their availability and interest. A 7-point hedonic scale was used, all the judges evaluating all the samples using a randomised

  10. Effect of on-chip filter on Coulomb blockade thermometer

    International Nuclear Information System (INIS)

    Coulomb Blockade Thermometer (CBT) is a primary thermometer based on electric conductance of normal tunnel junction arrays. One limitation for CBT use at the lowest temperatures has been due to environmental noise heating. To improve on this limitation, we have done measurements on CBT sensors fabricated with different on-chip filtering structures in a dilution refrigerator with a base temperature of 10 mK. The CBT sensors were produced with a wafer scale tunnel junction process. We present how the different on-chip filtering schemes affect the limiting saturation temperatures and show that CBT sensors with proper on-chip filtering work at temperatures below 20 mK and are tolerant to noisy environment.

  11. VLSI design of 3D display processing chip for binocular stereo displays

    Institute of Scientific and Technical Information of China (English)

    Ge Chenyang; Zheng Nanning

    2010-01-01

    In order to develop the core chip supporting binocular stereo displays for head mounted display(HMD)and glasses-TV,a very large scale integrated(VLSI)design scheme is proposed by using a pipeline architecture for 3D display processing chip(HMD100).Some key techniques including stereo display processing and high precision video scaling based bicubic interpolation,and their hardware implementations which improve the image quality are presented.The proposed HMD100 chip is verified by the field-programmable gate array(FPGA).As one of innovative and high integration SoC chips,HMD100 is designed by a digital and analog mixed circuit.It can support binocular stereo display,has better scaling effect and integration.Hence it is applicable in virtual reality(VR),3D games and other microdisplay domains.

  12. Heat and mass transfers at liquid/vapor interfaces with phase-change: proposal for a large-scale modeling of interfaces

    International Nuclear Information System (INIS)

    discontinuous model thus benefiting from the knowledge acquired in DNS numerical methods. Transfers between phases are modified and the interfacial velocity is redefined considering the time evolution of curvature and the velocity jump at the interface. As a result, the normal momentum jump is modified. A tangential velocity jump is also introduced to cancel out the sub-resolution of the boundary layer. From a thermal point of view, the classical saturation condition is recovered; the phase-change rate not only depends on the conduction heat flux but a contribution from the sub-grid velocity and temperature correlations must be added to account for the poor resolution of the thermal boundary layer. As for single-phase LES, ISS modeling enables local-scale simulations of industrial configurations. It is the first step of a multi-scale approach towards turbulent bubbly flows. In this thesis, we illustrates how to bridge the gap between DNS and averaged descriptions from reference results obtained on condensing bubbles in a pseudo-turbulent subcooled liquid. Averaged quantities are compared with correlations for the condensation sink term used in the two-fluid model. We are able to underline the phase-change enhancement with increasing void fraction. It shows that this path could be used to improve the understanding of the strong two-way coupling between flow dynamics and interfacial heat transfers. (author)

  13. S-Chip Technical Assistance

    Data.gov (United States)

    U.S. Department of Health & Human Services — The page will provide access to reports and other published products designed to assist states with complicated S-Chip technical issues. The reports and products...

  14. On-Chip Optical Squeezing

    CERN Document Server

    Dutt, Avik; Manipatruni, Sasikanth; Gaeta, Alexander L; Nussenzveig, Paulo; Lipson, Michal

    2013-01-01

    A squeezed light source, i.e. a source with ultra low noise level, below the standard quantum limit (SQL), can enable quantum enhanced sensing, spectroscopy[1, 2], metrology[3] and quantum information processing[4,5]. To date, such a non classical light source on-chip, scalable, compact and robust has not been demonstrated. Such a source could not only enable ultrasensitive measurements on chip, but also provide squeezing over high bandwidths in contrast to most sources which usually rely on large optical cavities with narrow bandwidths. Here, we report the observation of squeezed light in an on-chip monolithically integrated platform, generated in a micron-size silicon nitride oscillator[6] with GHz cavity linewidth. We show 1.7dB noise squeezing, i.e. reduction of the noise level below the standard quantum limit, of the intensity difference between two beams generated by an on-chip optical parametric oscillator.

  15. A 1,000 Frames/s Programmable Vision Chip with Variable Resolution and Row-Pixel-Mixed Parallel Image Processors

    OpenAIRE

    2009-01-01

    A programmable vision chip with variable resolution and row-pixel-mixed parallel image processors is presented. The chip consists of a CMOS sensor array, with row-parallel 6-bit Algorithmic ADCs, row-parallel gray-scale image processors, pixel-parallel SIMD Processing Element (PE) array, and instruction controller. The resolution of the image in the chip is variable: high resolution for a focused area and low resolution for general view. It implements gray-scale and binary mathematical morpho...

  16. Whole-Teflon microfluidic chips

    OpenAIRE

    Ren, Kangning; Dai, Wen; Zhou, Jianhua; Su, Jing; Wu, Hongkai

    2011-01-01

    Although microfluidics has shown exciting potential, its broad applications are significantly limited by drawbacks of the materials used to make them. In this work, we present a convenient strategy for fabricating whole-Teflon microfluidic chips with integrated valves that show outstanding inertness to various chemicals and extreme resistance against all solvents. Compared with other microfluidic materials [e.g., poly(dimethylsiloxane) (PDMS)] the whole-Teflon chip has a few more advantages, ...

  17. Analysis of trace levels of sulfonamides in fish tissue using micro-scale pipette tip-matrix solid-phase dispersion and fast liquid chromatography tandem mass spectrometry.

    Science.gov (United States)

    Shen, Qing; Jin, Renyao; Xue, Jing; Lu, Yanbin; Dai, Zhiyuan

    2016-03-01

    A micro-scale matrix solid-phase dispersion (MSPD) technique, using hydrophilic-lipophilic balance (HLB) material as sorbent and a pipette tip (PT) as the cartridge, was developed for the extraction and purification of sulfonamides in fish tissue. Eluates from PT-MSPD were analyzed using fast liquid chromatography and tandem mass spectrometry (LC-MS/MS). The method was fully validated; good linearity was obtained with correlation coefficients greater than 0.99. Precision and accuracy (RSD%) were in the range 1.4-10.3% while mean recoveries were 70.6-95.5%. With this technique, 15 aquatic samples (Collichthys niveatus) were analyzed for sulfonamides. The whole procedure took only 13min (5min for PT-MSPD and 8min for LC), materials for each sample included 5.1mL solvents (0.3mL for PT-MSPD and 4.8mL for LC), and 20mg HLB sorbent. Generally speaking, this method is indeed practical and particularly suitable for widespread drug residue analysis. PMID:26471586

  18. Addition of low concentrations of an ionic liquid to a base oil reduces friction over multiple length scales: a combined nano- and macrotribology investigation.

    Science.gov (United States)

    Li, Hua; Somers, Anthony E; Howlett, Patrick C; Rutland, Mark W; Forsyth, Maria; Atkin, Rob

    2016-03-01

    The efficacy of ionic liquids (ILs) as lubricant additives to a model base oil has been probed at the nanoscale and macroscale as a function of IL concentration using the same materials. Silica surfaces lubricated with mixtures of the IL trihexyl(tetradecyl)phosphonium bis(2,4,4-trimethylpentyl)phosphinate and hexadecane are probed using atomic force microscopy (AFM) (nanoscale) and ball-on-disc tribometer (macroscale). At both length scales the pure IL is a much more effective lubricant than hexadecane. At the nanoscale, 2.0 mol% IL (and above) in hexadecane lubricates the silica as well as the pure IL due to the formation of a robust IL boundary layer that separates the sliding surfaces. At the macroscale the lubrication is highly load dependent; at low loads all the mixtures lubricate as effectively as the pure IL, whereas at higher loads rather high concentrations are required to provide IL like lubrication. Wear is also pronounced at high loads, for all cases except the pure IL, and a tribofilm is formed. Together, the nano- and macroscales results reveal that the IL is an effective lubricant additive - it reduces friction - in both the boundary regime at the nanoscale and mixed regime at the macroscale. PMID:26865399

  19. Recovery of N and P from Urine by Struvite Precipitation Followed by Combined Stripping with Digester Sludge Liquid at Full Scale

    Directory of Open Access Journals (Sweden)

    Hansruedi Siegrist

    2013-08-01

    Full Text Available A novel ammonia stripping method, including a CO2 pre-stripper was used to treat a mix of supernatant liquor from an anaerobic digester and urine in order to recycle nitrogen as ammonium sulfate at full-scale in the WWTP Kloten/Opfikon. Waste streams were not generated, since the ammonia was recovered as a marketable nitrogen fertilizer, turning a waste product into a valuable product. The efficiency of this system was increased by means of the addition of pre-treated urine collected separately at EAWAG building. The separation step was performed by the use of water free urinals and urine diversion flush toilets. An increase of 10% in the liquid flux with the addition of the urine translated into a 40% increase of the ammonia concentration in the inlet of the stripping unit. The achievement of these percentages generated a proportional increase in the fertilizer production. The urine pre-treatment was carried out by adding magnesium to produce a precipitate of struvite. The first experiments with the combined treatment showed the feasibility of the combination of the separation and pre-treatment steps.

  20. Proposal for a Full-Scale Prototype Single-Phase Liquid Argon Time Projection Chamber and Detector Beam Test at CERN

    CERN Document Server

    Kutter, T

    2015-01-01

    The Deep Underground Neutrino Experiment (DUNE) will use a large liquid argon (LAr) detector to measure the CP violating phase, determine the neutrino mass hier- archy and perform precision tests of the three-flavor paradigm in long-baseline neutrino oscillations. The detector will consist of four modules each with a fiducial mass of 10 kt of LAr and due to its unprecedented size will allow sensitive searches for proton decay and the detection and measurement of electron neutrinos from core collapse supernovae [1]. The first 10 kt module will use single-phase LAr detection technique and be itself modular in design. The successful manufacturing, installation and operation of several full-scale detector components in a suitable configuration represents a critical engineering milestone prior to the construction and operation of the first full 10 kt DUNE detector module at the SURF underground site. A charged particle beam test of a prototype detector will provide critical calibration measurements as well as inva...

  1. Two dimensional, electronic particle tracking in liquids with a graphene-based magnetic sensor array

    Science.gov (United States)

    Neumann, Rodrigo F.; Engel, Michael; Steiner, Mathias

    2016-07-01

    The investigation and control of liquid flow at the nanometer scale is a key area of applied research with high relevance to physics, chemistry, and biology. We introduce a method and a device that allows the spatial resolution of liquid flow by integrating an array of graphene-based magnetic (Hall) sensors that is used for tracking the movement of magnetic nanoparticles immersed in a liquid under investigation. With a novel device concept based on standard integration processes and experimentally verified material parameters, we numerically simulate the performance of a single sensor pixel, as well as the whole sensor array, for tracking magnetic nanoparticles having typical properties. The results demonstrate that the device enables (a) the detection of individual nanoparticles in the liquid with high accuracy and (b) the reconstruction of a particle's flow-driven trajectory across the integrated sensor array with sub-pixel precision as a function of time, in what we call the ``Magnetic nanoparticle velocimetry'' technique. Since the method does not rely on optical detection, potential lab-on-chip applications include particle tracking and flow analysis in opaque media at the sub-micron scale.The investigation and control of liquid flow at the nanometer scale is a key area of applied research with high relevance to physics, chemistry, and biology. We introduce a method and a device that allows the spatial resolution of liquid flow by integrating an array of graphene-based magnetic (Hall) sensors that is used for tracking the movement of magnetic nanoparticles immersed in a liquid under investigation. With a novel device concept based on standard integration processes and experimentally verified material parameters, we numerically simulate the performance of a single sensor pixel, as well as the whole sensor array, for tracking magnetic nanoparticles having typical properties. The results demonstrate that the device enables (a) the detection of individual

  2. Laser Direct Writing of Thick Hybrid Polymers for Microfluidic Chips

    Directory of Open Access Journals (Sweden)

    Akanksha Singh

    2014-07-01

    Full Text Available This work presents patterning of thick (10–50 µm hybrid polymer structures of ORMOCER® by laser direct writing. ORMOCER® combine polymer-like fabrication processes with glass-like surface chemistry that is beneficial for many bio-microfluidic applications. ORMOCER® is liquid before exposure, so patterning is done by contact-free lithography, such as proximity exposure. With laser direct writing, we obtained higher resolution patterns, with smaller radius of curvature (~2–4 µm, compared to proximity exposure (~10–20 µm. Process parameters were studied to find the optimal dose for different exposure conditions and ORMOCER® layer thicknesses. Two fluidic devices were successfully fabricated: a directional wetting device (fluidic diode and an electrophoresis chip. The fluidic diode chip operation depends on the sharp corner geometry and water contact angle, and both have been successfully tailored to obtain diodicity. Electrophoresis chips were used to separate of two fluorescent dyes, rhodamine 123 and fluorescein. The electrophoresis chip also made use of ORMOCER® to ORMOCER® bonding.

  3. Chip-on-flex with 5-micron features

    Science.gov (United States)

    Salmon, Peter C.

    2003-01-01

    A new module packaging method is proposed for electronic systems comprising a motherboard and integrated circuit (IC) chips. Pitches of 10 microns for conductive traces, and 100 microns for bonding pads are achievable. The enabling technology is glass panel manufacture, using equipment and techniques similar to those employed for fabricating liquid crystal display (LCD) panels. Flexible circuits are produced on a glass carrier using a release layer, and the carrier is removed after most of the processing is complete. IC chips are stud bumped and flip chip bonded to wells filled with solder, provided on the flexible circuit. The fabrication density achievable with wafer level packaging (WLP) using silicon wafers is substantially more than is needed for module packaging, as described herein. It is possible to provide WLP performance on glass at a much lower cost. The conductor features on glass are fine enough for the most demanding packaging and assembly techniques. The lowered cost of glass applies to the interconnection circuit plus assembly, test and rework. A test method called Tester-On-Board (TOB) is proposed, employing special-purpose test chips that are directly mounted in the system and mimic the capabilities of external testers. Methods for hermetic sealing, electromagnetic screening, and high-density off-board connections are also proposed.

  4. Liquid migration in sheared unsaturated granular media

    OpenAIRE

    Mani, Roman; Kadau, Dirk; Herrmann, Hans J.

    2012-01-01

    We show how liquid migrates in sheared unsaturated granular media using a grain scale model for capillary bridges. Liquid is redistributed to neighboring contacts after rupture of individual capillary bridges leading to redistribution of liquid on large scales. The liquid profile evolution coincides with a recently developed continuum description for liquid migration in shear bands. The velocity profiles which are linked to the migration of liquid as well as the density profiles of wet and dr...

  5. Reducing the Edge Chipping for Capillary End Face Grinding and Polishing

    Directory of Open Access Journals (Sweden)

    Hošek J.

    2013-05-01

    Full Text Available This paper presents results of glass capillary end face grinding and polishing by approach that reduces the edge chipping. Brittle materials have natural tendency for edge chipping what leads to beveling the sharp edges. Not beveled sharp edges on glass capillary are important for special applications like surface tension measurement of small liquid samples. We use common grinding and polishing process for capillary end face machining modified with gradual decreasing of grinding load based on the relation of the critical chipping load. Achieved surface roughness is measured using atomic force microscopy (AFM. Capillary inner edge quality is checked both with optical microscopes and electron microscope too. We achieved a non-chipped capillary inner edge with radius down to 100 nm.

  6. Sorption and desorption of toluene, m-xylene, p-cresol and water by natural rubber chips

    Directory of Open Access Journals (Sweden)

    Duangkamol Dechojarassri

    2006-09-01

    Full Text Available The transport mechanism of several pure liquid organic substances into natural rubber chips composed of different fillers was investigated. It was found that, for the same type of chips, the Fickian diffusion of toluene was the fastest, followed by m-xylene, water and p-cresol. The toluene uptake was highest which was as high as 3.42 times of the chip weight. This was closely followed by m- xylene uptake, which was much higher than p-cresol uptake and water uptake which was only 0.02 times of the chip weight, implying that natural rubber could be used to remove these organic substances contaminated in water. The desorption of substances into air followed the similar trend as sorption. Besides, for any substances, the results showed that unfilled chips had the largest sorption capacity, followed by ones with calcium carbonate and carbon black.

  7. On-chip spectroscopy with thermally tuned high-Q photonic crystal cavities

    Energy Technology Data Exchange (ETDEWEB)

    Liapis, Andreas C., E-mail: andreas.liapis@gmail.com; Gao, Boshen; Siddiqui, Mahmudur R. [The Institute of Optics, University of Rochester, Rochester, New York 14627 (United States); Shi, Zhimin [Department of Physics, University of South Florida, Tampa, Florida 33620 (United States); Boyd, Robert W. [The Institute of Optics, University of Rochester, Rochester, New York 14627 (United States); Department of Physics and School of Electrical Engineering and Computer Science, University of Ottawa, Ottawa, Ontario K1N 6N5 (Canada)

    2016-01-11

    Spectroscopic methods are a sensitive way to determine the chemical composition of potentially hazardous materials. Here, we demonstrate that thermally tuned high-Q photonic crystal cavities can be used as a compact high-resolution on-chip spectrometer. We have used such a chip-scale spectrometer to measure the absorption spectra of both acetylene and hydrogen cyanide in the 1550 nm spectral band and show that we can discriminate between the two chemical species even though the two materials have spectral features in the same spectral region. Our results pave the way for the development of chip-size chemical sensors that can detect toxic substances.

  8. On-chip spectroscopy with thermally-tuned high-Q photonic crystal cavities

    CERN Document Server

    Liapis, Andreas C; Siddiqui, Mahmudur R; Shi, Zhimin; Boyd, Robert W

    2015-01-01

    Spectroscopic methods are a sensitive way to determine the chemical composition of potentially hazardous materials. Here, we demonstrate that thermally-tuned high-Q photonic crystal cavities can be used as a compact high-resolution on-chip spectrometer. We have used such a chip-scale spectrometer to measure the absorption spectra of both acetylene and hydrogen cyanide in the 1550 nm spectral band, and show that we can discriminate between the two chemical species even though the two materials have spectral features in the same spectral region. Our results pave the way for the development of chip-size chemical sensors that can detect toxic substances.

  9. Applying Partial Power-Gating to Direction-Sliced Network-on-Chip

    OpenAIRE

    Feng Wang; Xiantuo Tang; Zuocheng Xing

    2015-01-01

    Network-on-Chip (NoC) is one of critical communication architectures for future many-core systems. As technology is continually scaling down, on-chip network meets the increasing leakage power crisis. As a leakage power mitigation technique, power-gating can be utilized in on-chip network to solve the crisis. However, the network performance is severely affected by the disconnection in the conventional power-gated NoC. In this paper, we propose a novel partial power-gating approach to improve...

  10. On-chip spectroscopy with thermally tuned high-Q photonic crystal cavities

    International Nuclear Information System (INIS)

    Spectroscopic methods are a sensitive way to determine the chemical composition of potentially hazardous materials. Here, we demonstrate that thermally tuned high-Q photonic crystal cavities can be used as a compact high-resolution on-chip spectrometer. We have used such a chip-scale spectrometer to measure the absorption spectra of both acetylene and hydrogen cyanide in the 1550 nm spectral band and show that we can discriminate between the two chemical species even though the two materials have spectral features in the same spectral region. Our results pave the way for the development of chip-size chemical sensors that can detect toxic substances

  11. Patterning liquids on inkjet-imprinted surfaces with highly adhesive superhydrophobicity.

    Science.gov (United States)

    Bao, Bin; Sun, Jiazhen; Gao, Meng; Zhang, Xingye; Jiang, Lei; Song, Yanlin

    2016-05-01

    The rapidly increasing research interest in microfluidics, microreactors and solution-processable fabrication technologies requires the development of patterning techniques to obtain large-scale functional liquid arrays. To achieve this objective, photolithography, microcontact printing and mask-based UV irradiation have been utilized to physically or chemically pattern surfaces into templates where ordered arrays of liquid materials are constructed. However, these methods require elaborately fabricated templates or expensive vacuum-deposited masks that restrict their practical applications. Herein, we fabricate physically patterned superhydrophobic surfaces with high adhesion by modifying inkjet-imprinted surfaces through nanoparticle deposition, and utilize these surfaces as templates for liquid patterning. Various functional liquid materials are patterned into defined shapes through a simple dipping-withdrawing process. Moreover, functional material patterns such as photonic crystal patterns, arrays of inorganic nanoparticles and crystals are formed after solvent evaporation of the liquid droplets. Furthermore, chemical reactions can be carried out on the patterns. These surfaces demonstrate excellent performance in liquid patterning, which will find numerous applications in optoelectronic devices, lab-on-chip devices, microreactors, and related fields. PMID:27098655

  12. Ionic liquids for enzymatic sensing

    OpenAIRE

    Fraser, Kevin J.; Byrne, Robert; Benito-Lopez, Fernando; Warren, Susan; Dempsey, Eithne; Diamond, Dermot

    2011-01-01

    The key challenges currently faced in lab-on-a-chip biochemical sensor developments are device reliability and power consumption. The major issues faced in terms of device reliability are liquid handling over extended periods of time, as the micro-dimensioned fluidic channels are prone to blockage, and unreliable micro pumps/valves. The overall aim of this proposal is to develop a biocompatible molecular sensor that will address these key issues which are holding back biocompatible sensors te...

  13. Atom chip gravimeter

    Science.gov (United States)

    Schubert, Christian; Abend, Sven; Gebbe, Martina; Gersemann, Matthias; Ahlers, Holger; Müntinga, Hauke; Matthias, Jonas; Sahelgozin, Maral; Herr, Waldemar; Lämmerzahl, Claus; Ertmer, Wolfgang; Rasel, Ernst

    2016-04-01

    Atom interferometry has developed into a tool for measuring rotations [1], accelerations [2], and testing fundamental physics [3]. Gravimeters based on laser cooled atoms demonstrated residual uncertainties of few microgal [2,4] and were simplified for field applications [5]. Atomic gravimeters rely on the interference of matter waves which are coherently manipulated by laser light fields. The latter can be interpreted as rulers to which the position of the atoms is compared. At three points in time separated by a free evolution, the light fields are pulsed onto the atoms. First, a coherent superposition of two momentum states is produced, then the momentum is inverted, and finally the two trajectories are recombined. Depending on the acceleration the atoms experienced, the number of atoms detected in the output ports will change. Consequently, the acceleration can be determined from the output signal. The laser cooled atoms with microkelvin temperatures used in state-of-the-art gravimeters impose limits on the accuracy [4]. Therefore, ultra-cold atoms generated by Bose-Einstein condensation and delta-kick collimation [6,7] are expected to be the key for further improvements. These sources suffered from a low flux implying an incompatible noise floor, but a competitive performance was demonstrated recently with atom chips [8]. In the compact and robust setup constructed for operation in the drop tower [6] we demonstrated all steps necessary for an atom chip gravimeter with Bose-Einstein condensates in a ground based operation. We will discuss the principle of operation, the current performance, and the perspectives to supersede the state of the art. The authors thank the QUANTUS cooperation for contributions to the drop tower project in the earlier stages. This work is supported by the German Space Agency (DLR) with funds provided by the Federal Ministry for Economic Affairs and Energy (BMWi) due to an enactment of the German Bundestag under grant numbers DLR 50WM

  14. Modelling of the oxide scale formation on Fe-Cr steel during exposure in liquid lead-bismuth eutectic in the 450-600 C temperature range

    Energy Technology Data Exchange (ETDEWEB)

    Martinelli, L.; Balbaud-Celerier, F. [CEA, DEN, DPC, SCCME, Laboratoire d' Etude de la Corrosion Non Aqueuse, F-91191 Gif-sur-Yvette (France)

    2011-06-15

    Previous studies showed that the oxidation of T91 (Fe-9Cr martensitic steel) in liquid Pb-Bi eutectic leads to the formation of a duplex oxide layer containing an inner Fe{sub 2.3}Cr{sub 0.7}O{sub 4} spinel layer and an upper magnetite layer. The magnetite layer is easily removed by the Pb-Bi flow when the oxygen concentration is low and the flow velocity is high. This phenomenon is not currently understood. The magnetite layer growth rate is limited by the iron diffusion in the oxide layer lattice. The Fe-Cr spinel layer grows in the nanometric cavities formed at the Fe-Cr spinel /T91 interface by the outwards diffusion of iron. Due to this mechanism the growth rate of the Fe-Cr spinel layer is linked to that of magnetite. A modelling of this mechanism is presented. The modelling is in agreement with the experimental data in the case of a high oxygen concentration. However, the calculated oxide scale thicknesses are systematically lower than the experimental values in the case of a low oxygen concentration when the iron diffusion only occurs via interstitials in the oxide scale. Consequently, the estimation of the iron diffusion coefficient, when diffusion occurs via interstitials, is not reliable. To have a better estimation of this iron diffusion coefficient in the Fe-Cr spinel, when diffusion occurs via interstitials, a fit is done using experimental data coming from the European DEMETRA project. Although this evaluation is only based on a fit on the experimental data, it permits to estimate the oxide layer growth kinetics in case of the formation of the described duplex oxide layer, for each oxygen concentration (leading to a vacancy and/or an interstitial diffusion), each temperature between 450 and 620 C and each hydrodynamic flow. This model shows that the hydrodynamic flow affects the corrosion rate only by the removal of the upper magnetite layer leading to an increase of the oxygen concentration at the spinel/magnetite interface. The oxidation mechanism

  15. Stem end chip defect in tubers used for potato chip production

    Science.gov (United States)

    Stem-end chip defect (SECD) is a serious tuber quality concern that affects chipping potatoes (Solanum tuberosum). SECD defect is characterized by dark-colored vascular tissues and adjacent cortical tissues at the tuber stem-end portion of potato chips after frying. Chips with SECD are unattractive ...

  16. Nanowire liquid pumps

    Science.gov (United States)

    Huang, Jian Yu; Lo, Yu-Chieh; Niu, Jun Jie; Kushima, Akihiro; Qian, Xiaofeng; Zhong, Li; Mao, Scott X.; Li, Ju

    2013-04-01

    The ability to form tiny droplets of liquids and control their movements is important in printing or patterning, chemical reactions and biological assays. So far, such nanofluidic capabilities have principally used components such as channels, nozzles or tubes, where a solid encloses the transported liquid. Here, we show that liquids can flow along the outer surface of solid nanowires at a scale of attolitres per second and the process can be directly imaged with in situ transmission electron microscopy. Microscopy videos show that an ionic liquid can be pumped along tin dioxide, silicon or zinc oxide nanowires as a thin precursor film or as beads riding on the precursor film. Theoretical analysis suggests there is a critical film thickness of ~10 nm below which the liquid flows as a flat film and above which it flows as discrete beads. This critical thickness is the result of intermolecular forces between solid and liquid, which compete with liquid surface energy and Rayleigh-Plateau instability.

  17. Measurements of millimeter wave test structures for high speed chip testing

    OpenAIRE

    De Keulenaer, Timothy; Ban, Yu; Torfs, Guy; Sercu, Stefaan; Geest, Jan van de; Bauwelinck, Johan

    2014-01-01

    This paper presents the frequency domain characterization of very high bandwidth connectorized traces and a millimeter wave rat race coupler. These connectorized differential grounded coplanar waveguide traces, essential for the testability of high speed integrated circuits, have a measured flat frequency response up to 67GHz which indicates correct connector footprint and transmission line design. The differential traces narrow down to a chip scale pitch of 150 μm allowing direct flip chip c...

  18. Lab-on-a-chip devices and micro-total analysis systems a practical guide

    CERN Document Server

    Svendsen, Winnie

    2015-01-01

    This book covers all the steps in order to fabricate a lab-on-a-chip device starting from the idea, the design, simulation, fabrication and final evaluation. Additionally, it includes basic theory on microfluidics essential to understand how fluids behave at such reduced scale. Examples of successful histories of lab-on-a-chip systems that made an impact in fields like biomedicine and life sciences are also provided.

  19. Mechanism for salt scaling

    Science.gov (United States)

    Valenza, John J., II

    Salt scaling is superficial damage caused by freezing a saline solution on the surface of a cementitious body. The damage consists of the removal of small chips or flakes of binder. The discovery of this phenomenon in the early 1950's prompted hundreds of experimental studies, which clearly elucidated the characteristics of this damage. In particular it was shown that a pessimum salt concentration exists, where a moderate salt concentration (˜3%) results in the most damage. Despite the numerous studies, the mechanism responsible for salt scaling has not been identified. In this work it is shown that salt scaling is a result of the large thermal expansion mismatch between ice and the cementitious body, and that the mechanism responsible for damage is analogous to glue-spalling. When ice forms on a cementitious body a bi-material composite is formed. The thermal expansion coefficient of the ice is ˜5 times that of the underlying body, so when the temperature of the composite is lowered below the melting point, the ice goes into tension. Once this stress exceeds the strength of the ice, cracks initiate in the ice and propagate into the surface of the cementitious body, removing a flake of material. The glue-spall mechanism accounts for all of the characteristics of salt scaling. In particular, a theoretical analysis is presented which shows that the pessimum concentration is a consequence of the effect of brine pockets on the mechanical properties of ice, and that the damage morphology is accounted for by fracture mechanics. Finally, empirical evidence is presented that proves that the glue-small mechanism is the primary cause of salt scaling. The primary experimental tool used in this study is a novel warping experiment, where a pool of liquid is formed on top of a thin (˜3 mm) plate of cement paste. Stresses in the plate, including thermal expansion mismatch, result in warping of the plate, which is easily detected. This technique revealed the existence of

  20. Development, Fabrication and Characterisation of Atom Chips

    OpenAIRE

    Groth, Sönke

    2006-01-01

    Atom chips are robust and extremely powerful toolboxes for quantum optical experiments, since they make it possible to create exceedingly precise magnetic traps for neutral atoms with minimal field modulations. Accurate manipulation of trapped atoms is feasible with magnetic and electric fields created on the atom chip. Therefore atom chips with high quality surfaces and extremely well defined wires were build (roughness < 20nm). Furthermore new generations of atom chips were developed, like ...

  1. Treatment of propylene glycol monomethyl ether acetate in air streams by a biofilter packed with fern chips.

    Science.gov (United States)

    Chou, Ming-Shean; Chang, Yu-Feng; Perng, Hsiao-Ting

    2008-12-01

    This study aimed to develop a biofilter packed only with fern chips for the removal of airborne propylene glycol monomethyl ether acetate (PGMEA). Fern chips could avoid the shortcomings of traditional media, such as compaction, drying, and breakdown, which lead to the performance failure of the biofilters. In addition, the fern chip medium has the following merits: (1) simplicity in composition; (2) low pressure drop for gas flow (PGMEA concentrations of 100-750 mg x m(-3), volumetric organic loading of PGMEA removal efficacy of around 94%. Instant milk powder or liquid milk was essential to the good and stable performance of the biofilter for PGMEA removal. PMID:19189757

  2. Sorption and desorption of toluene, m-xylene, p-cresol and water by natural rubber chips

    OpenAIRE

    Duangkamol Dechojarassri; Savalee Jaroenkarn; Pore Jumpathi; Panu Danwanichakul

    2006-01-01

    The transport mechanism of several pure liquid organic substances into natural rubber chips composed of different fillers was investigated. It was found that, for the same type of chips, the Fickian diffusion of toluene was the fastest, followed by m-xylene, water and p-cresol. The toluene uptake was highest which was as high as 3.42 times of the chip weight. This was closely followed by m- xylene uptake, which was much higher than p-cresol uptake and water uptake which was only 0.02 times of...

  3. Near Field On Chip RFID Antenna Design

    OpenAIRE

    Vargas, Alberto; Vojtech, Lukas

    2010-01-01

    The process of fabricating the antenna on the top of the RFID chip eliminates the need for a separated and costly expensive process for antenna printing and assemblage, compulsory for a separated "off-chip" antenna which is much more times larger than the chip itself. This

  4. On-Chip Optical Squeezing

    Science.gov (United States)

    Dutt, Avik; Luke, Kevin; Manipatruni, Sasikanth; Gaeta, Alexander L.; Nussenzveig, Paulo; Lipson, Michal

    2015-04-01

    We report the observation of all-optical squeezing in an on-chip monolithically integrated CMOS-compatible platform. Our device consists of a low-loss silicon nitride microring optical parametric oscillator (OPO) with a gigahertz cavity linewidth. We measure 1.7 dB (5 dB corrected for losses) of sub-shot-noise quantum correlations between bright twin beams generated in the microring four-wave-mixing OPO pumped above threshold. This experiment demonstrates a compact, robust, and scalable platform for quantum-optics and quantum-information experiments on chip.

  5. Planar ion chip design for scalable quantum information processing

    Institute of Scientific and Technical Information of China (English)

    Wan Jin-Yin; Wang Yu-Zhu; Liu Liang

    2008-01-01

    We investigate a planar ion chip design with a two-dimensional array of linear ion traps for scalable quantum information processing.Qubits are formed from the internal electronic states of trapped 40Ca+ ions.The segmented electrodes reside in a single plane on a substrate and a grounded metal plate separately,a combination of appropriaterf and DC potentials is applied to them for stable ion confinement.Every two adjacent electrodes can generate a linear ion trap in and between the electrodes above the chip at a distance dependent on the geometrical scale and other considerations.The potential distributions are calculated by using a static electric field qualitatively.This architecture provides a conceptually simple avenue to achieving the microfabrication and large-scale quantum computation based on the axrays of trapped ions.

  6. Microtraps and Atom Chips: Toolboxes for Cold Atom Physics

    OpenAIRE

    Feenstra, L.; Andersson, L. M.; Schmiedmayer, J.

    2003-01-01

    Magnetic microtraps and Atom Chips are safe, small-scale, reliable and flexible tools to prepare ultra-cold and degenerate atom clouds as sources for various atom-optical experiments. We present an overview of the possibilities of the devices and indicate how a microtrap can be used to prepare and launch a Bose-Einstein condensate for use in an atom clock or an interferometer.

  7. Invisibility Cloak Printed on a Photonic Chip

    CERN Document Server

    Feng, Zhen; Zhao, Yu-Xi; Gao, Jun; Qiao, Lu-Feng; Yang, Ai-Lin; Lin, Xiao-Feng; Jin, Xian-Min

    2016-01-01

    Invisibility cloak capable of hiding an object can be achieved by properly manipulating electromagnetic field. Such a remarkable ability has been shown in transformation and ray optics. Alternatively, it may be realistic to create a spatial cloak by means of confining electromagnetic field in three-dimensional arrayed waveguides and introducing appropriate collective curvature surrounding an object. We realize the artificial structure in borosilicate by femtosecond laser direct writing, where we prototype up to 5000 waveguides to conceal millimeter-scale volume. We characterize the performance of the cloak by normalized cross correlation, tomography analysis and continuous three-dimensional viewing angle scan. Our results show invisibility cloak can be achieved in waveguide optics. Furthermore, directly printed invisibility cloak on a photonic chip may enable controllable study and novel applications in classical and quantum integrated photonics, such as invisualising a coupling or swapping operation with on-...

  8. Soil chip convey of lunar subsurface auger drill

    Science.gov (United States)

    Zhao, Deming; Tang, Dewei; Hou, Xuyan; Jiang, Shengyuan; Deng, Zongquan

    2016-05-01

    Celestial body subsurface drilling and sampling is a key aspect of near-earth exploration projects. In these sample return missions, the auger drill system is universally used due to the environment and detector load limits. The common failure that the auger faces is chip chocking, which can raise the torque and cause the drill to stick. This paper builds auger drill models describing chip flow in the auger groove to balance geometric parameters, functional capability, and reliability. The features of chip flow are summarized and verified by a series of discrete element method simulations. In contrast to previous auger design, a convey capability factor is defined to indicate the auger's chip removal capacity, and the role of pitch angle and other parameters is assessed through motion analysis of the lunar soil flow process. The theory is verified by testing the drill penetrating speed limit, which combines drill geometry and motion parameters. This work provides a new method for design and optimization of low speed auger drill systems and research on particle flow with small scale mechanical constraints.

  9. LIQUID CHROMATOGRAPHIC SEPARATION OF THE ENANTIOMERS OF TRANS-CHLORDANE, CIS-CHLORDANE, HEPTACHLOR, HEPTACHLOR EPOXIDE AND ALPHA-HEXACHLOROCYCLOHEXANE WITH APPLICATION TO SMALL-SCALE PREPARATIVE SEPARATION

    Science.gov (United States)

    Analytical high-performance liquid chromatographic separations of the individual enantiomers of five polychlorinated compounds were obtained on polysaccharide stereoselective HPLC columns. The enantiomers of the pesticides trans-chlordane, cis-chlordane and heptachlor were separa...

  10. FERMI multi-chip module

    CERN Multimedia

    This FERMI multi-chip module contains five million transistors. 25 000 of these modules will handle the flood of information through parts of the ATLAS and CMS detectors at the LHC. To select interesting events for recording, crucial decisions are taken before the data leaves the detector. FERMI modules are being developed at CERN in partnership with European industry.

  11. Fiber cavities for atom chips

    OpenAIRE

    Klappauf, B.G.; Horak, P.; Kazansky, P. G.

    2003-01-01

    We present experimental realizations of several micro-cavities, constructed from standard fiber optic components, which meet the theoretical criteria for single atom detection from laser-cooled samples. We discuss integration of these cavities into state-of-the-art 'atom chips'.

  12. Kinerja Pengeringan Chip Ubi Kayu

    Directory of Open Access Journals (Sweden)

    Sandi Asmara

    2010-10-01

    Full Text Available Lampung Province is the largest producer of cassava in Indonesia. Cassava has a weakness that is easily damaged and could not be stored longer. To overcome this, there is a need of an effective drying process so that cassava can be processed into other materials of lower power use as well as its economic value. A hybrid drying system is one solution to resolve the issue. The purpose of this research is to study the performance of drying cassava chips by using a hybrid type of dryer rack. The process of drying cassava chips made using a three-stage treatments with three replicates with the input load of 30 kg of cassava chips. The results showed that the pattern of decline in water levels in each treatment is uneven. The time needed to dry cassava chips to reach the water content of 10% - 12% in the drying of materials using sunlight for 18 hours, using electrical energy for 16 hours and use the energy of sunlight and electricity for 12 hours. The higher temperatures produced the shorter the time required in the drying process. Electrical energy required for the drying process using electric energy was 91 440 kJ and drying using electrical energy and sunlight was 68600 kJ.

  13. Reconfigurable Networks-on-Chip

    CERN Document Server

    Chen, Sao-Jie; Tsai, Wen-Chung; Hu, Yu-Hen

    2012-01-01

    This book provides a comprehensive survey of recent progress in the design and implementation of Networks-on-Chip. It addresses a wide spectrum of on-chip communication problems, ranging from physical, network, to application layers. Specific topics that are explored in detail include packet routing, resource arbitration, error control/correction, application mapping, and communication scheduling. Additionally, a novel bi-directional communication channel NoC (BiNoC) architecture is described, with detailed explanation.   Written for practicing engineers in need of practical knowledge about the design and implementation of networks-on-chip; Includes tutorial-like details to introduce readers to a diverse range of NoC designs, as well as in-depth analysis for designers with NoC experience to explore advanced issues; Describes a variety of on-chip communication architectures, including a novel bi-directional communication channel NoC.     From the Foreword: Overall this book shows important advances over the...

  14. Engineering a Brain Cancer Chip for High-throughput Drug Screening.

    Science.gov (United States)

    Fan, Yantao; Nguyen, Duong Thanh; Akay, Yasemin; Xu, Feng; Akay, Metin

    2016-01-01

    Glioblastoma multiforme (GBM) is the most common and malignant of all human primary brain cancers, in which drug treatment is still one of the most effective treatments. However, existing drug discovery and development methods rely on the use of conventional two-dimensional (2D) cell cultures, which have been proven to be poor representatives of native physiology. Here, we developed a novel three-dimensional (3D) brain cancer chip composed of photo-polymerizable poly(ethylene) glycol diacrylate (PEGDA) hydrogel for drug screening. This chip can be produced after a few seconds of photolithography and requires no silicon wafer, replica molding, and plasma bonding like microfluidic devices made of poly(dimethylsiloxane) (PDMS). We then cultured glioblastoma cells (U87), which formed 3D brain cancer tissues on the chip, and used the GBM chip to perform combinatorial treatment of Pitavastatin and Irinotecan. The results indicate that this chip is capable of high-throughput GBM cancer spheroids formation, multiple-simultaneous drug administration, and a massive parallel testing of drug response. Our approach is easily reproducible, and this chip has the potential to be a powerful platform in cases such as high-throughput drug screening and prolonged drug release. The chip is also commercially promising for other clinical applications, including 3D cell culture and micro-scale tissue engineering. PMID:27151082

  15. Engineering a Brain Cancer Chip for High-throughput Drug Screening

    Science.gov (United States)

    Fan, Yantao; Nguyen, Duong Thanh; Akay, Yasemin; Xu, Feng; Akay, Metin

    2016-01-01

    Glioblastoma multiforme (GBM) is the most common and malignant of all human primary brain cancers, in which drug treatment is still one of the most effective treatments. However, existing drug discovery and development methods rely on the use of conventional two-dimensional (2D) cell cultures, which have been proven to be poor representatives of native physiology. Here, we developed a novel three-dimensional (3D) brain cancer chip composed of photo-polymerizable poly(ethylene) glycol diacrylate (PEGDA) hydrogel for drug screening. This chip can be produced after a few seconds of photolithography and requires no silicon wafer, replica molding, and plasma bonding like microfluidic devices made of poly(dimethylsiloxane) (PDMS). We then cultured glioblastoma cells (U87), which formed 3D brain cancer tissues on the chip, and used the GBM chip to perform combinatorial treatment of Pitavastatin and Irinotecan. The results indicate that this chip is capable of high-throughput GBM cancer spheroids formation, multiple-simultaneous drug administration, and a massive parallel testing of drug response. Our approach is easily reproducible, and this chip has the potential to be a powerful platform in cases such as high-throughput drug screening and prolonged drug release. The chip is also commercially promising for other clinical applications, including 3D cell culture and micro-scale tissue engineering. PMID:27151082

  16. Development of an ion-pair liquid chromatography-high resolution mass spectrometry method for determination of organophosphate pesticide metabolites in large-scale biomonitoring studies.

    Science.gov (United States)

    Cequier, Enrique; Sakhi, Amrit Kaur; Haug, Line Småstuen; Thomsen, Cathrine

    2016-07-01

    Organophosphate based pesticides are widely used in the agricultural sector, and exposure to these chemicals is common for the general population. Pesticides are toxic due to the inhibition of acetylcholinesterases, and the potential for adverse health effects have been investigated in past and recent studies. Human biomonitoring of organophosphate pesticide exposure is carried out through the determination of the metabolites in urine (dialkylphosphates, DAPs). Hereby we present a new method for determination of the 6 non-specific metabolites dimethyl phosphate (DMP), diethyl phosphate (DEP), dimethyl thiophosphate (DMTP), diethyl thiophosphate (DETP), dimethyl dithiophosphate (DMDTP), and diethyl dithiophosphate (DEDTP) in urine based on off-line solid phase extraction (anion exchange, 96-well plates) followed by ion-pair ultra-performance liquid chromatography time-of-flight mass spectrometry. Recoveries and accuracies in control urine spiked at 5ng/mL ranged from 48% to109% and from 91% to 115%, respectively. The method limits of detection for the DAPs were 1.2ng/mL for DMP, 0.38ng/mL for DEP, 0.20ng/mL for DMTP, 0.33ng/mL for DETP, 0.64ng/mL for DMDTP, and 0.15ng/mL for DEDTP. The method was applied to samples from a Norwegian mother/child study group (n=48/56) and the DAPs detection frequencies in urine from mothers and children were about: 40% for DMP, 95% for DEP, 96% for DMTP, 50% for DETP, 15% for DMDTP, and 1% for DEDTP. In both mothers and children, the most abundant DAPs were DMTP (median 2.4/5.2ng/mL) and DEP (median 2.6/3.4ng/mL) followed by DMP (median 1.5/2.1ng/mL). The SG corrected concentrations of DEP and DETP in mothers were statistically higher than in children (p-valuepesticides in these mothers, or significant differences in toxicokinetics between adults and children. The method was proven robust and suitable for large-scale biomonitoring studies. PMID:27264744

  17. Pilot-Scale Investigation of Liquid Aluminum Filtration through Ceramic Foam Filters: Comparison between Coulter Counter Measurements and Metallographic Analysis of Spent Filters

    OpenAIRE

    Duval, Hervé; Rivière, Carlos; Laé, Émilie; Le Brun, Pierre; Guillot, Jean-Bernard

    2009-01-01

    A pilot has been designed to study the mechanisms associated with liquid aluminum filtrationthrough ceramic foam filters (CFFs). Before entering the filtering bowl, the liquid metal isseeded with massive artificial inclusions. A theoretical analysis of the filtration of massiveinclusions shows that there are two preponderant deposition mechanisms, i.e., direct interceptionand sedimentation, which explain qualitatively the effect of the operating conditions on themeasured filtration efficiency...

  18. Programmable synaptic chip for electronic neural networks

    Science.gov (United States)

    Moopenn, A.; Langenbacher, H.; Thakoor, A. P.; Khanna, S. K.

    1988-01-01

    A binary synaptic matrix chip has been developed for electronic neural networks. The matrix chip contains a programmable 32X32 array of 'long channel' NMOSFET binary connection elements implemented in a 3-micron bulk CMOS process. Since the neurons are kept off-chip, the synaptic chip serves as a 'cascadable' building block for a multi-chip synaptic network as large as 512X512 in size. As an alternative to the programmable NMOSFET (long channel) connection elements, tailored thin film resistors are deposited, in series with FET switches, on some CMOS test chips, to obtain the weak synaptic connections. Although deposition and patterning of the resistors require additional processing steps, they promise substantial savings in silicon area. The performance of synaptic chip in a 32-neuron breadboard system in an associative memory test application is discussed.

  19. Chip-based human liver-intestine and liver-skin co-cultures--A first step toward systemic repeated dose substance testing in vitro.

    Science.gov (United States)

    Maschmeyer, Ilka; Hasenberg, Tobias; Jaenicke, Annika; Lindner, Marcus; Lorenz, Alexandra Katharina; Zech, Julie; Garbe, Leif-Alexander; Sonntag, Frank; Hayden, Patrick; Ayehunie, Seyoum; Lauster, Roland; Marx, Uwe; Materne, Eva-Maria

    2015-09-01

    Systemic repeated dose safety assessment and systemic efficacy evaluation of substances are currently carried out on laboratory animals and in humans due to the lack of predictive alternatives. Relevant international regulations, such as OECD and ICH guidelines, demand long-term testing and oral, dermal, inhalation, and systemic exposure routes for such evaluations. So-called "human-on-a-chip" concepts are aiming to replace respective animals and humans in substance evaluation with miniaturized functional human organisms. The major technical hurdle toward success in this field is the life-like combination of human barrier organ models, such as intestine, lung or skin, with parenchymal organ equivalents, such as liver, at the smallest biologically acceptable scale. Here, we report on a reproducible homeostatic long-term co-culture of human liver equivalents with either a reconstructed human intestinal barrier model or a human skin biopsy applying a microphysiological system. We used a multi-organ chip (MOC) platform, which provides pulsatile fluid flow within physiological ranges at low media-to-tissue ratios. The MOC supports submerse cultivation of an intact intestinal barrier model and an air-liquid interface for the skin model during their co-culture with the liver equivalents respectively at (1)/100.000 the scale of their human counterparts in vivo. To increase the degree of organismal emulation, microfluidic channels of the liver-skin co-culture could be successfully covered with human endothelial cells, thus mimicking human vasculature, for the first time. Finally, exposure routes emulating oral and systemic administration in humans have been qualified by applying a repeated dose administration of a model substance - troglitazone - to the chip-based co-cultures. PMID:25857839

  20. Automated, Ultra-Sterile Solid Sample Handling and Analysis on a Chip

    Science.gov (United States)

    Mora, Maria F.; Stockton, Amanda M.; Willis, Peter A.

    2013-01-01

    There are no existing ultra-sterile lab-on-a-chip systems that can accept solid samples and perform complete chemical analyses without human intervention. The proposed solution is to demonstrate completely automated lab-on-a-chip manipulation of powdered solid samples, followed by on-chip liquid extraction and chemical analysis. This technology utilizes a newly invented glass micro-device for solid manipulation, which mates with existing lab-on-a-chip instrumentation. Devices are fabricated in a Class 10 cleanroom at the JPL MicroDevices Lab, and are plasma-cleaned before and after assembly. Solid samples enter the device through a drilled hole in the top. Existing micro-pumping technology is used to transfer milligrams of powdered sample into an extraction chamber where it is mixed with liquids to extract organic material. Subsequent chemical analysis is performed using portable microchip capillary electrophoresis systems (CE). These instruments have been used for ultra-highly sensitive (parts-per-trillion, pptr) analysis of organic compounds including amines, amino acids, aldehydes, ketones, carboxylic acids, and thiols. Fully autonomous amino acid analyses in liquids were demonstrated; however, to date there have been no reports of completely automated analysis of solid samples on chip. This approach utilizes an existing portable instrument that houses optics, high-voltage power supplies, and solenoids for fully autonomous microfluidic sample processing and CE analysis with laser-induced fluorescence (LIF) detection. Furthermore, the entire system can be sterilized and placed in a cleanroom environment for analyzing samples returned from extraterrestrial targets, if desired. This is an entirely new capability never demonstrated before. The ability to manipulate solid samples, coupled with lab-on-a-chip analysis technology, will enable ultraclean and ultrasensitive end-to-end analysis of samples that is orders of magnitude more sensitive than the ppb goal given

  1. Wood chip delivery and research project at the Mikkeli region - PUUHA 93 - 95

    International Nuclear Information System (INIS)

    Large-scale forest chips delivery was started in 1993. Forest chips delivery contracts were made between the Etelae-Savon Energia Oy, the town of Mikkeli, the local forestry societies and the chip contractors in the autumn 1993. Forest chips were delivered from old sapling stands, first thinning sites and clear felling sites. The total energy wood amount acquired by the forestry societies and the town of Mikkeli in 1993 was about 45 000 bulk-m3, of which about 18 000 bulk-m3 was combusted in 1993. The main reason for this low consumption was the failures in the generator of the plant. Additionally, wastes from the mechanical wood processing industry was combusted more than planned (15 000 bulk-m3). About 500 bulk-m3 of building and stripping waste was also combusted. Follow-up of the costs was started in the beginning of the forest chip delivery, and actions for controlling and optimation of the large-scale chip delivery were started simultaneously. The storage programs for delivery logistics were evaluated, and the biofuel terminal, sited near the plant was planned. The crushing tests with building and stripping wastes were carried out as planned

  2. Heat capacity measurements of sub-nanoliter volumes of liquids using bimaterial microchannel cantilevers

    Science.gov (United States)

    Khan, M. F.; Miriyala, N.; Lee, J.; Hassanpourfard, M.; Kumar, A.; Thundat, T.

    2016-05-01

    Lab-on-a-Chip compatible techniques for thermal characterization of miniaturized volumes of liquid analytes are necessary in applications such as protein blotting, DNA melting, and drug development, where samples are either rare or volume-limited. We developed a closed-chamber calorimeter based on a bimaterial microchannel cantilever (BMC) for sub-nanoliter level thermal analysis. When the liquid-filled BMC is irradiated with infrared (IR) light at a specific wavelength, the IR absorption by the liquid analyte results in localized heat generation and the subsequent deflection of the BMC, due to a thermal expansion mismatch between the constituent materials. The time constant of the deflection, which is dependent upon the heat capacity of the liquid analyte, can be directly measured by recording the time-dependent bending of the BMC. We have used the BMC to quantitatively measure the heat capacity of five volatile organic compounds. With a deflection noise level of ˜10 nm and a signal-to-noise ratio of 68:1, the BMC offers a sensitivity of 30.5 ms/(J g-1 K-1) and a resolution of 23 mJ/(g K) for ˜150 pl liquid for heat capacity measurements. This technique can be used for small-scale thermal characterization of different chemical and biological samples.

  3. Parametric down-conversion photon pair source on a nanophotonic chip

    CERN Document Server

    Guo, Xiang; Schuck, Carsten; Jung, Hojoong; Cheng, Risheng; Tang, Hong X

    2016-01-01

    Quantum photonic chips, which integrate quantum light sources alongside active and passive optical elements, as well as single photon detectors, show great potential for photonic quantum information processing and quantum technology. Mature semiconductor nanofabrication processes allow for scaling such photonic integrated circuits to on-chip networks of increasing complexity. Second order nonlinear materials are the method of choice for generating photonic quantum states in the overwhelming part of linear optic experiments using bulk components but integration with waveguide circuitry on a nanophotonic chip proved to be challenging. Here we demonstrate such an on-chip parametric down-conversion source of photon pairs based on second order nonlinearity in an Aluminum nitride microring resonator. We show the potential of our source for quantum information processing by measuring high-visibility antibunching of heralded single photons with nearly ideal state purity. Our down conversion source operates with high ...

  4. A microwave resonator integrated on a polymer microfluidic chip

    Science.gov (United States)

    Kiss, S. Z.; Rostas, A. M.; Heidinger, L.; Spengler, N.; Meissner, M. V.; MacKinnon, N.; Schleicher, E.; Weber, S.; Korvink, J. G.

    2016-09-01

    We describe a novel stacked split-ring type microwave (MW) resonator that is integrated into a 10 mm by 10 mm sized microfluidic chip. A straightforward and scalable batch fabrication process renders the chip suitable for single-use applications. The resonator volume can be conveniently loaded with liquid sample via microfluidic channels patterned into the mid layer of the chip. The proposed MW resonator offers an alternative solution for compact in-field measurements, such as low-field magnetic resonance (MR) experiments requiring convenient sample exchange. A microstrip line was used to inductively couple MWs into the resonator. We characterised the proposed resonator topology by electromagnetic (EM) field simulations, a field perturbation method, as well as by return loss measurements. Electron paramagnetic resonance (EPR) spectra at X-band frequencies were recorded, revealing an electron-spin sensitivity of 3.7 ·1011spins ·Hz - 1 / 2G-1 for a single EPR transition. Preliminary time-resolved EPR experiments on light-induced triplet states in pentacene were performed to estimate the MW conversion efficiency of the resonator.

  5. Dispensing and bio-functionalization of giant unilamellar vesicles on a chip

    Energy Technology Data Exchange (ETDEWEB)

    Kaler, K V I S; Prakash, R, E-mail: kaler@ucalgary.ca [2500 University Drive NW, Calgary, AB - T2N 1N4 (Canada)

    2011-06-23

    Giant unilamellar vesicles (GUVs), typically >10 {mu}m in diameter, can serve as interesting models for mimicking biological membranes and furthermore can be usefully leveraged in drug delivery and bio-sensor applications. In this paper, we have demonstrated a chip based vesicle dispensing scheme that utilizes liquid dielectrophoresis (L-DEP) to dispense, precisely positioned GUVs over a range of diameter 30 - 100 {mu}m, a capability that is not readily achieved by either conventional or microchannel technology. These GUVs can also be individually addressed and tailored for a variety of applications such as bio-sensing and cell-on-a-chip.

  6. Real-time tunability of chip-based light source enabled by microfluidic mixing

    DEFF Research Database (Denmark)

    Olsen, Brian Bilenberg; Rasmussen, Torben; Balslev, Søren; Kristensen, Anders

    2006-01-01

    concentration of rhodamine 6G dye inside two integrated vertical resonators, since both the refractive index and the gain profile are influenced by the dye concentration. The effect on the refractive index and the gain profile of rhodamine 6G in ethanol is investigated and the continuous tuning of the laser......We demonstrate real-time tunability of a chip-based liquid light source enabled by microfluidic mixing. The mixer and light source are fabricated in SU-8 which is suitable for integration in SU-8-based laboratory-on-a-chip microsystems. The tunability of the light source is achieved by changing the...

  7. Silicon MEMS for Detection of Liquid and Solid Fronts

    OpenAIRE

    Wei, J.

    2010-01-01

    High-precision manipulation of small-size objects is an attractive and challenging topic for both industrial production and fundamental scientific research. The capability of monitoring micro-samples during handling is essential to the accuracy and efficiency of a handling system for both liquid and solid samples. When handling liquid samples with small volume, tools (such as drop-on-demand inkjet dispensers and on-chip micro-fluidic channels) are often used to generate droplets or liquid seg...

  8. Neural Cell Chip Based Electrochemical Detection of Nanotoxicity

    Directory of Open Access Journals (Sweden)

    Md. Abdul Kafi

    2015-07-01

    Full Text Available Development of a rapid, sensitive and cost-effective method for toxicity assessment of commonly used nanoparticles is urgently needed for the sustainable development of nanotechnology. A neural cell with high sensitivity and conductivity has become a potential candidate for a cell chip to investigate toxicity of environmental influences. A neural cell immobilized on a conductive surface has become a potential tool for the assessment of nanotoxicity based on electrochemical methods. The effective electrochemical monitoring largely depends on the adequate attachment of a neural cell on the chip surfaces. Recently, establishment of integrin receptor specific ligand molecules arginine-glycine-aspartic acid (RGD or its several modifications RGD-Multi Armed Peptide terminated with cysteine (RGD-MAP-C, C(RGD4 ensure farm attachment of neural cell on the electrode surfaces either in their two dimensional (dot or three dimensional (rod or pillar like nano-scale arrangement. A three dimensional RGD modified electrode surface has been proven to be more suitable for cell adhesion, proliferation, differentiation as well as electrochemical measurement. This review discusses fabrication as well as electrochemical measurements of neural cell chip with particular emphasis on their use for nanotoxicity assessments sequentially since inception to date. Successful monitoring of quantum dot (QD, graphene oxide (GO and cosmetic compound toxicity using the newly developed neural cell chip were discussed here as a case study. This review recommended that a neural cell chip established on a nanostructured ligand modified conductive surface can be a potential tool for the toxicity assessments of newly developed nanomaterials prior to their use on biology or biomedical technologies.

  9. Convenient liquidity measure for Financial markets

    OpenAIRE

    Oleh Danyliv; Bruce Bland; Daniel Nicholass

    2014-01-01

    A liquidity measure based on consideration and price range is proposed. Initially defined for daily data, Liquidity Index (LIX) can also be estimated via intraday data by using a time scaling mechanism. The link between LIX and the liquidity measure based on weighted average bid-ask spread is established. Using this liquidity measure, an elementary liquidity algebra is possible: from the estimation of the execution cost, the liquidity of a basket of instruments is obtained. A formula for the ...

  10. The nanoaquarium: A nanofluidic platform for in situ transmission electron microscopy in liquid media

    Science.gov (United States)

    Grogan, Joseph M.

    There are many scientifically interesting and technologically relevant nanoscale phenomena that take place in liquid media. Examples include aggregation and assembly of nanoparticles; colloidal crystal formation; liquid phase growth of structures such as nanowires; electrochemical deposition and etching for fabrication processes and battery applications; interfacial phenomena; boiling and cavitation; and biological interactions. Understanding of these fields would benefit greatly from real-time, in situ transmission electron microscope (TEM) imaging with nanoscale resolution. Most liquids cannot be imaged by traditional TEM due to evaporation in the high vacuum environment and the requirement that samples be very thin. Liquid-cell in situ TEM has emerged as an exciting new experimental technique that hermetically seals a thin slice of liquid between two electron transparent membranes to enable TEM imaging of liquid-based processes. This work presents details of the fabrication of a custom-made liquid-cell in situ TEM device, dubbed the nanoaquarium. The nanoaquarium's highlights include an exceptionally thin sample cross section (10s to 100s of nm); wafer scale processing that enables high-yield mass production; robust hermetic sealing that provides leak-free operation without use of glue, epoxy, or any polymers; compatibility with lab-on-chip technology; and on-chip integrated electrodes for sensing and actuation. The fabrication process is described, with an emphasis on direct wafer bonding. Experimental results involving direct observation of colloid aggregation using an aqueous solution of gold nanoparticles are presented. Quantitative analysis of the growth process agrees with prior results and theory, indicating that the experimental technique does not radically alter the observed phenomenon. For the first time, in situ observations of nanoparticles at a contact line and in an evaporating thin film of liquid are reported, with applications for techniques such

  11. Solid state silicon based condenser microphone for hearing aid, has transducer chip and IC chip between intermediate chip and openings on both sides of intermediate chip, to allow sound towards diaphragm

    DEFF Research Database (Denmark)

    2000-01-01

    NOVELTY - A silicon transducer chip (1) has parallel backplate and movable diaphragm (12) and forms an electrical capacitor. The chip and electronic circuit chip (3) are provided on either sides of intermediate chip (2). The chip (2) has openings (4,10) between two sides of the chip, to allow sound...... towards diaphragm. Surface of the chip (2) has electrical conductors (14) to connect chip with IC chip (3). USE - For use in miniature electroacoustic devices such as hearing aid. ADVANTAGE - Since sound inlet is covered by filter, dust, moisture and other impurities do not obstruct interior and sound...

  12. Microchip systems for imaging liquid and high temperature processes in TEM & SEM

    DEFF Research Database (Denmark)

    Jensen, Eric; Canepa, Silvia; Møller-Nilsen, Rolf Erling Robberstad;

    2014-01-01

    measurementson high temperature fuel cell systems. For imaging processes in liquids, our SEM system enables imaging on-chip microelectrodes andusing standard built-in reference electrodes [2]. To get higher resolution in TEM, we have createda monolithic chip system with suspended microfabricated channels [3......]. Both systems will allowhigh resolution imaging of heterogeneous electrochemical processes such as those in batteries.Based on the suspended microfluidic channels, we are also developing microchips that enableultrafast freezing of processes in liquids....

  13. Lab-on-a-Chip Instrument Development for Titan Exploration

    Science.gov (United States)

    Willis, P. A.; Greer, F.; Fisher, A.; Hodyss, R. P.; Grunthaner, F.; Jiao, H.; Mair, D.; Harrison, J.

    2009-12-01

    This contribution will describe the initial stages of a new ASTID-funded research program initiated in Fall 2009 aimed at lab-on-a-chip system development for astrobiological investigations on Titan. This technology development builds off related work at JPL and Berkeley [1-3] on the ultrasensitive compositional and chiral analysis of amino acids on Mars in order to search for signatures of past or present life. The Mars-focused instrument system utilizes a microcapillary electrophoresis (μCE) system integrated with on-chip perfluoropolyether (PFPE) membrane valves and pumps for automated liquid sample handling, on-chip derivitization of samples with fluorescent tags, dilution, and mixing with standards for data calibration. It utilizes a four-layer wafer stack design with CE channels patterned in glass, along with a PFPE membrane, a pneumatic manifold layer, and a fluidic bus layer. Three pneumatically driven on-chip diaphragm valves placed in series are used to peristaltically pump reagents, buffers, and samples to and from capillary electrophoresis electrode well positions. Electrophoretic separation occurs in the all-glass channels near the base of the structure. The Titan specific lab-on-a-chip system under development here focuses its attention on the unique organic chemistry of Titan. In order to chromatographically separate mixtures of neutral organics such as polycyclic aromatic hydrocarbons (PAHs), the Titan-specific microfluidic platform utilizes the related technique of microcapillary electrochromatography (μCEC). This technique differs from conventional μCE in that microchannels are filled with a porous stationary phase that presents surfaces upon which analyte species can adsorb/desorb. It is this additional surface interaction that enables separations of species critical to the understanding of the astrobiological potential of Titan that are not readily separated by the μCE technique. We have developed two different approaches for the integration

  14. Commercial-scale demonstration of the Liquid Phase Methanol (LPMEOH{trademark}) process. Technical progress report No. 1, October 1, 1993--June 30, 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-12-31

    The Liquid Phase Methanol (LPMEOH{trademark}) Demonstration Project at Kingsport, Tennessee is a $213.7 million cooperative agreement between the U.S. Department of Energy (DOE) and Air Products and Chemicals, Inc. (Air Products). This document describes major accomplishments in project development for Fiscal Year 1993. The preliminary process hazards review, project safety plan, schedule, and cost management report are included as appendices. The demonstration is sited at the Eastman Chemical Company (Eastman) complex in Kingsport. Air Products and Eastman are working on a partnership agreement which will form the Air Products Liquid Phase Conversion Company, L.P. As a limited partner in the venture, Eastman will own and operate the demonstration unit. The project involves the construction of a 260 tons-per-day (TPD) or 80,000 gallon per day methanol demonstration unit utilizing an existing coal-derived synthesis gas from Eastman. The new equipment consists of synthesis gas feed preparation and compression, liquid phase reactor and auxiliaries, product distillation, and utilities. The technology to be demonstrated was developed by Air Products in a DOE sponsored program that started in 1981. Originally tested at a small, DOE-owned experimental facility in LaPorte, Texas, the LPMEOH{trademark} process offers several advantages over current methods of making methanol. This liquid phase process suspends fine catalyst particles in an inert liquid, forming a slurry. The liquid dissipates heat from the chemical reaction away from the catalyst surface, protecting the catalyst, and allowing the gas-to-methanol reaction to proceed at higher rates. The process is ideally suited to the type of gas produced by modem coal gasifiers. At the Eastman Chemical complex, the technology will be integrated with existing coal gasifiers to demonstrate the commercially important aspects of the operation of the LPMEOH{trademark} Process to produce methanol.

  15. Investigation on pore structure and small-scale agglomeration behaviour in liquid phase sintered SiC using small angle neutron scattering

    Indian Academy of Sciences (India)

    D Sen; J Bahadur; S Mazumder; T Mahata; M Syambabu; P K Sinha

    2008-11-01

    Mesoscopic density fluctuations in liquid phase sintered silicon carbide have been investigated using small angle neutron scattering (SANS). The increase in the additives results in the modification in the pore size distribution and to some extent the total porosity. SANS revealed a mass fractal nature of the agglomerated matrix microstructure. The fractal dimension of the matrix does not change appreciably with the additives although the upper cut-off value of the fractal decreases significantly with the increase in the additives. The liquid phase sintering due to the presence of additives helps to achieve higher level of densification. However, the agglomeration hinders achievement of the fully dense pellets.

  16. Silicon-chip-based ultrafast optical oscilloscope.

    Science.gov (United States)

    Foster, Mark A; Salem, Reza; Geraghty, David F; Turner-Foster, Amy C; Lipson, Michal; Gaeta, Alexander L

    2008-11-01

    only highly developed electronic and optical materials of complementary metal-oxide-semiconductor (CMOS)-compatible silicon-on-insulator technology and single-mode optical fibre. The mature silicon-on-insulator platform and the ability to integrate electronics with these CMOS-compatible photonics offer great promise to extend this technology into commonplace bench-top and chip-scale instruments. PMID:18987739

  17. Collective Memory Transfers for Multi-Core Chips

    Energy Technology Data Exchange (ETDEWEB)

    Michelogiannakis, George; Williams, Alexander; Shalf, John

    2013-11-13

    Future performance improvements for microprocessors have shifted from clock frequency scaling towards increases in on-chip parallelism. Performance improvements for a wide variety of parallel applications require domain-decomposition of data arrays from a contiguous arrangement in memory to a tiled layout for on-chip L1 data caches and scratchpads. How- ever, DRAM performance suffers under the non-streaming access patterns generated by many independent cores. We propose collective memory scheduling (CMS) that actively takes control of collective memory transfers such that requests arrive in a sequential and predictable fashion to the memory controller. CMS uses the hierarchically tiled arrays formal- ism to compactly express collective operations, which greatly improves programmability over conventional prefetch or list- DMA approaches. CMS reduces application execution time by up to 32% and DRAM read power by 2.2×, compared to a baseline DMA architecture such as STI Cell.

  18. Silicon-chip source of bright photon pairs.

    Science.gov (United States)

    Jiang, Wei C; Lu, Xiyuan; Zhang, Jidong; Painter, Oskar; Lin, Qiang

    2015-08-10

    Integrated quantum photonics relies critically on the purity, scalability, integrability, and flexibility of a photon source to support diverse quantum functionalities on a single chip. Here we report a chip-scale photon-pair source on the silicon-on-insulator platform that utilizes dramatic cavity-enhanced four-wave mixing in a high-Q silicon microdisk resonator. The device is able to produce high-quality photon pairs at different wavelengths with a high spectral brightness of 6.24×10(7) pairs/s/mW(2)/GHz and photon-pair correlation with a coincidence-to-accidental ratio of 1386 ± 278 while pumped with a continuous-wave laser. The superior performance, together with the structural compactness and CMOS compatibility, opens up a great avenue towards quantum silicon photonics with capability of multi-channel parallel information processing for both integrated quantum computing and long-haul quantum communication. PMID:26367942

  19. Darwinian Evolution on a Chip

    OpenAIRE

    Paegel, Brian M.; Joyce, Gerald F.

    2008-01-01

    Author Summary The principles of Darwinian evolution are fundamental to understanding biological organization and have been applied to the development of functional molecules in the test tube. Laboratory evolution is greatly accelerated compared with natural evolution, but it usually requires substantial manipulation by the experimenter. Here we describe a system that relies on computer control and microfluidic chip technology to automate the directed evolution of functional molecules, subjec...

  20. A survey of research and practices of network-on-chip

    DEFF Research Database (Denmark)

    Bjerregaard, Tobias; Mahadevan, Shankar

    2006-01-01

    The scaling of microchip technologies has enabled large scale systems-on-chip (SoC). Network-on-chip (NoC) research addresses global communication in SoC, involving (i) a move from computation-centric to communication-centric design and (ii) the implementation of scalable communication structures....... This survey presents a perspective on existing NoC research. We define the following abstractions: system, network adapter, network, and link to explain and structure the fundamental concepts. First, research relating to the actual network design is reviewed. Then system level design and modeling are...

  1. Commercial-scale demonstration of the Liquid Phase Methanol (LPMEOH{trademark}) process. Technical progress report number 2, July 1--September 30, 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-12-31

    The project involves the construction of a 260 tons-per-day (TPD) or 80,000 gallon per day methanol demonstration unit utilizing an existing coal-derived synthesis gas from Eastman. The new equipment consists of synthesis gas feed preparation and compression, liquid phase reactor and auxiliaries, product distillation, and utilities. The technology to be demonstrated was developed by Air Products in a DOE sponsored program that started in 1981. Originally tested at a small, DOE-owned experimental facility in LaPorte, Texas, the LPMEOH{trademark} process offers several advantages over current methods of making methanol. This liquid phase process suspends fine catalyst particles in an inert liquid, forming a slurry. The liquid dissipates heat from the chemical reaction away from the catalyst surface, protecting the catalyst and allowing the gas-to-methanol reaction to proceed at higher rates. The process is ideally suited to the type of gas produced by modern coal gasifiers. At the Eastman Chemical complex, the technology will be integrated with existing coal gasifiers to demonstrate the commercially important aspects of the operation of the LPMEOH{trademark} Process to produce methanol. A four-year demonstration will prove the commercial applicability of the process. An off-site product-use test program will prove the suitability of the methanol as a transportation fuel and as a fuel for stationary applications in the power industry.

  2. On-chip aqueous two-phase system (ATPS) formation, consequential self-mixing, and their influence on drop-to-drop aqueous two-phase extraction kinetics

    Science.gov (United States)

    Wijethunga, Pavithra A. L.; Moon, Hyejin

    2015-09-01

    Aqueous two-phase systems (ATPSs) allow an advantageous aqueous two-phase extraction process (ATPE), a special type of liquid-liquid extraction. Compared with conventional liquid-liquid extraction using aqueous/organic extraction media, ATPE is known to provide relatively easy mass transfer and a gentle environment for biological separation applications. Considering the recent interest in microscale ATPE, we aimed to study (i) the potential of preparing ATPS droplets on a digital microfluidic device, and (ii) the influence of the fluidic dynamics created during the formation of ATPS, with the goal of enhancing on-chip ATPE process. On-chip ATPS formation was evaluated by preparing a series of ATPSs on electrowetting on dielectric digital microfluidic chips and comparing their characteristics with the same ATPSs prepared at macroscale using conventional procedures. An enhanced on-chip drop-to-drop ATPE process was achieved by incorporating a self-mixing condition created during ATPSformation. Results indicate a successful on-chip ATPS preparation as well as enhanced extraction performance by self-mixing in the absence of forced mixing. Findings of this research suggest an alternative, simple, yet adequate technique to provide mixing for on-chip applications, such as sample preparation in portable microfluidics, for which it is unfavorable to implement complicated mixing sequences or complex device geometries.

  3. Local pressure components and interfacial tensions of a liquid film in the vicinity of a solid surface with a nanometer-scale slit pore obtained by the perturbative method

    Energy Technology Data Exchange (ETDEWEB)

    Fujiwara, K., E-mail: ku.fujiwara@screen.co.jp [R and D Department, SCREEN Holdings Co., Ltd., 322 Furukawa-cho, Hazukashi, Fushimi-ku, Kyoto, Kyoto 612-8486 (Japan); Department of Mechanical Engineering, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871 (Japan); Shibahara, M., E-mail: siba@mech.eng.osaka-u.ac.jp [Department of Mechanical Engineering, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871 (Japan)

    2015-03-07

    A classical molecular dynamics simulation was conducted for a liquid-solid interfacial system with a nanometer-scale slit pore in order to reveal local thermodynamic states: local pressure components and interfacial tensions of a liquid film in the vicinity of the slit. The simulation also examined the transition mechanism between the two states of the liquid film: (a) liquid film on the slit and (b) liquid film in the slit, based on the local thermodynamic quantities from a molecular point of view. An instantaneous expression of the local pressure components and interfacial tensions, which is based on a volume perturbation, was presented to investigate time-dependent phenomena in molecular dynamics simulations. The interactions between the particles were described by the 12-6 Lennard-Jones potential, and effects of the fluid-solid interaction intensity on the local pressure components and interfacial tensions of the fluid in the vicinity of the slit were examined in detail by the presented perturbative method. The results revealed that the local pressure components tangential to the solid surface in the vicinity of the 1st fluid layer from the solid surface are different in a two dimensional plane, and the difference became pronounced in the vicinity of the corner of the slit, for cases where the fluid-solid interaction intensities are relatively strong. The results for the local interfacial tensions of the fluid inside the slit suggested that the local interfacial tensions in the vicinity of the 2nd and 3rd layers of the solid atoms from the entrance of the slit act as a trigger for the transition between the two states under the influence of a varying fluid-solid interaction.

  4. Local pressure components and interfacial tensions of a liquid film in the vicinity of a solid surface with a nanometer-scale slit pore obtained by the perturbative method

    International Nuclear Information System (INIS)

    A classical molecular dynamics simulation was conducted for a liquid-solid interfacial system with a nanometer-scale slit pore in order to reveal local thermodynamic states: local pressure components and interfacial tensions of a liquid film in the vicinity of the slit. The simulation also examined the transition mechanism between the two states of the liquid film: (a) liquid film on the slit and (b) liquid film in the slit, based on the local thermodynamic quantities from a molecular point of view. An instantaneous expression of the local pressure components and interfacial tensions, which is based on a volume perturbation, was presented to investigate time-dependent phenomena in molecular dynamics simulations. The interactions between the particles were described by the 12-6 Lennard-Jones potential, and effects of the fluid-solid interaction intensity on the local pressure components and interfacial tensions of the fluid in the vicinity of the slit were examined in detail by the presented perturbative method. The results revealed that the local pressure components tangential to the solid surface in the vicinity of the 1st fluid layer from the solid surface are different in a two dimensional plane, and the difference became pronounced in the vicinity of the corner of the slit, for cases where the fluid-solid interaction intensities are relatively strong. The results for the local interfacial tensions of the fluid inside the slit suggested that the local interfacial tensions in the vicinity of the 2nd and 3rd layers of the solid atoms from the entrance of the slit act as a trigger for the transition between the two states under the influence of a varying fluid-solid interaction

  5. Morphological control via chemical and shear forces in block copolymer self-assembly in the lab-on-chip.

    Science.gov (United States)

    Wang, Chih-Wei; Sinton, David; Moffitt, Matthew G

    2013-02-26

    We investigate the effects of variation in chemical conditions (solvent composition, water content, polymer concentration, and added salt) on the morphologies formed by PS-b-PAA in DMF/dioxane/water mixtures in a two-phase gas-liquid segmented microfluidic reactor. The differences in morphologies between off-chip and on-chip self-assembly and on-chip morphological trends for different chemical conditions are explained by the interplay of top-down shear effects (coalescence and breakup) and bottom-up chemical forces. Using off-chip morphology results, we construct a water content-solvent composition phase diagram showing disordered, sphere, cylinder, and vesicle regions. On-chip morphologies are found to deviate from off-chip morphologies by three identified shear-induced paths: 1) sphere-to-cylinder, and 2) sphere-to-vesicle transitions, both via shear-induced coalescence when initial micelle sizes are small, and 3) cylinder-to-sphere transitions via shear-induced breakup when initial micelle sizes are large (high capillary number conditions). These pathways contribute to the generation of large extended bilayer aggregates uniquely on-chip, at either increased polymer or salt concentrations. Collectively these results demonstrate the broad utility of top-down directed molecular self-assembly in conjunction with chemical forces to control morphology and size of polymer colloids at the nanoscale. PMID:23311400

  6. Development of multistage distillation in a microfluidic chip.

    Science.gov (United States)

    Lam, K F; Cao, E; Sorensen, E; Gavriilidis, A

    2011-04-01

    Although there has been a lot of work on the development of microchemical processing systems such as micro-reactors and micro-sensors, little attention has been paid to micro-separation units, and in particular, microscale distillation. In this paper, various silicon-glass microscale distillation chips with different channel configurations were fabricated and tested. A temperature gradient was setup across the chip by heating and cooling the two ends. The feed was located at the middle of the microchannel. Arrays of micropillars were incorporated in order to guide the liquid flow. It was found that the separation performance was promoted by increasing the length of the microchannel. However, this created an imbalance of the liquid flows at the two sides of the microchannel and caused flooding. This hydrodynamic limitation was addressed by incorporating micropillars on both sides of the channel. The most efficient microdistillation chip consisted of a microchannel with 600 microns width and 40 cm length. Experimental results showed high efficiency for the separation of a 50 mol% acetone-water mixture when the heating and cooling temperature were 95 °C and 42 °C respectively. The concentrations of acetone were 3 mol% in the bottom stream and 95 mol% in the distillate, which was equivalent to at least 4 equilibrium stages at total reflux conditions. Furthermore, a 50 mol% methanol-toluene mixture was separated into nearly pure toluene in the bottom stream and 75 mol% methanol in the distillate. The performance of the microdistillation unit was reproducible in repeated tests. PMID:21327250

  7. Wireless network-on-chip: a survey

    OpenAIRE

    Shuai Wang; Tao Jin

    2014-01-01

    To alleviate the complex communication problems arising in the network-on-chip (NoC) architectures as the number of on-chip components increases, several novel interconnect infrastructures have been recently proposed to replace the traditional on-chip interconnection systems that are reaching their limits in terms of performance, power and area constraints. Wireless NoC (WiNoC) is among the most promising scalable interconnection architectures for future generation NoCs. In this study, the au...

  8. Wood chip production technology and costs for fuel in Namibia

    Energy Technology Data Exchange (ETDEWEB)

    Leinonen, A.

    2007-12-15

    steer and Nisula harvester head for felling, were tested at CCF. The most effective felling device in the tests appeared to be rotary saw in the skid steer. Based on these tests it was designed a new totally mechanized production chain. The working phases in this mechanized production chain are felling with a rotary saw in skid steer, compiling with a grapple fork in skid steer, drying in the heaps, chipping with a mobile chipper with a loader and road transport with a tractor trailer. This new production chain is not fully tested in Namibia. The calculated production and road transport costs of wood chips with the designed new mechanized production chain are about 15% lower than those of the semi-mechanized production chain. The production costs with the new mechanized production chain are 170.5 N dollar/wet ton (4.4 Euros/MWh) for 5 MWe power plant, 181.4 N dollar/wet ton (4.7 Euros/MWh) for 10 MWe power plant and 192.3 N dollar/wet ton (4.9 Euros/MWh) for 20 MWe power plant. The average road transport distance in the calculation is 30 km for a 5 MWe, 40 km for 10 MWe and 50 km for 20 MWe power plants. The production and road transport costs of wood chips from Okahandja to Van Eck power plant are 238.4 N dollar/wet ton (6.1 Euros/MWh) and from Otjiwarongo 350.3 N dollar/wet ton (9.0 Euros/MWh using the new mechanized wood chip production chain. The wet ton and MWh units are presented in 20 w-% moisture content. The designed mechanized production chain is very effective and suitable for large-scale wood chip production. With the new mechanized production chain the labour force demand of producing wood chips is 32 men for a 5 MWe, 65 men for 10 MWe and 136 men for 20 MWe power plant. The average yield in selective bush harvesting at CCF was 7.0 wet tons (20 w-%) per hectare. The annual total wood chip production area is 4 600 ha in the case of a 5 MWe power plant, 8 600 ha for a 10 MWe and 16 900 ha for 20 MWe power plant if the harvesting yield is 7.0 wet tons per ha

  9. Performance of High-Speed PWM Control Chips at Cryogenic Temperatures

    Science.gov (United States)

    Elbuluk, Malik E.; Gerber, Scott; Hammoud, Ahmad; Patterson, Richard; Overton, Eric

    2001-01-01

    The operation of power electronic systems at cryogenic temperatures is anticipated in many NASA space missions such as planetary exploration and deep space probes. In addition to surviving the space hostile environment, electronics capable of low temperature operation would contribute to improving circuit performance, increasing system efficiency, and reducing development and launch costs. As part of the NASA Glenn Low Temperature Electronics Program, several commercial high-speed Pulse Width Modulation (PWM) chips have been characterized in terms of their performance as a function of temperature in the range of 25 to -196 C (liquid nitrogen). These chips ranged in their electrical characteristics, modes of control, packaging options, and applications. The experimental procedures along with the experimental data obtained on the investigated chips are presented and discussed.

  10. Manipulation of superparamagnetic beads using on-chip current lines placed on a ferrite magnet

    Science.gov (United States)

    Wang, Z. H.; Lew, W. S.; Bland, J. A. C.

    2006-04-01

    Manipulation of superparamagnetic beads in a static solution is demonstrated using on-chip current striplines placed on a ferrite magnet. The ferrite magnet fits the requirement to enhance the bead's magnetic moment while still keeping beads randomly dispersed in the liquid, so allowing easy and selective manipulation of single beads. By applying currents up to hundreds of milliampere, the tapered stripline first attracts the beads to its edge, then the magnetic force along the edge drives the trapped beads moving continuously towards the chip center. On arriving into the chip central area (a square zone which acts as a site to collect the arriving beads), fine manipulation of selected single beads is further performed by switching on/off and/or tuning the current passing through the nearby quadruple striplines. We suggest that the present system may provide a simple but effective platform for handling magnetic tags for biological and biomedical applications.

  11. Heat transfer analysis of a programmable Josephson voltage standard chip operated with a mechanical cooler

    Science.gov (United States)

    Takahashi, Hikari; Maruyama, Michitaka; Amagai, Yasutaka; Yamamori, Hirotake; Kaneko, Nobu-hisa; Kiryu, Shogo

    2015-11-01

    We are developing a 10 V programmable Josephson voltage standard (PJVS) system using a 10 K mechanical cooler that enables liquid-helium-free operation. In our previous experiments, we identified a problem that the optimum bias operating points may be affected by the heating effect of the chip depending on the output voltage. In this study, we have observed cross-sectional and in-plane structures of the PJVS chip module in order to determine the cause of the heating effect. We perform a heat transfer analysis using the finite element method with several models based on the observation results. We confirm a temperature increase of approximately 100 mK at the chip surface, due mainly to unintended voids in the InSn solder.

  12. Photonic network-on-chip design

    CERN Document Server

    Bergman, Keren; Biberman, Aleksandr; Chan, Johnnie; Hendry, Gilbert

    2013-01-01

    This book provides a comprehensive synthesis of the theory and practice of photonic devices for networks-on-chip. It outlines the issues in designing photonic network-on-chip architectures for future many-core high performance chip multiprocessors. The discussion is built from the bottom up: starting with the design and implementation of key photonic devices and building blocks, reviewing networking and network-on-chip theory and existing research, and finishing with describing various architectures, their characteristics, and the impact they will have on a computing system. After acquainting

  13. Wax-bonding 3D microfluidic chips

    KAUST Repository

    Gong, Xiuqing

    2013-10-10

    We report a simple, low-cost and detachable microfluidic chip incorporating easily accessible paper, glass slides or other polymer films as the chip materials along with adhesive wax as the recycling bonding material. We use a laser to cut through the paper or film to form patterns and then sandwich the paper and film between glass sheets or polymer membranes . The hot-melt adhesive wax can realize bridge bonding between various materials, for example, paper, polymethylmethacrylate (PMMA) film, glass sheets, or metal plate. The bonding process is reversible and the wax is reusable through a melting and cooling process. With this process, a three-dimensional (3D) microfluidic chip is achievable by vacuating and venting the chip in a hot-water bath. To study the biocompatibility and applicability of the wax-based microfluidic chip, we tested the PCR compatibility with the chip materials first. Then we applied the wax-paper based microfluidic chip to HeLa cell electroporation (EP ). Subsequently, a prototype of a 5-layer 3D chip was fabricated by multilayer wax bonding. To check the sealing ability and the durability of the chip, green fluorescence protein (GFP) recombinant Escherichia coli (E. coli) bacteria were cultured, with which the chemotaxis of E. coli was studied in order to determine the influence of antibiotic ciprofloxacin concentration on the E. coli migration.

  14. Studies on spectroscopy of glycerol in THz range using microfluidic chip-integrated micropump

    Science.gov (United States)

    Su, Bo; Han, Xue; Wu, Ying; Zhang, Cunlin

    2014-11-01

    Terahertz time-domain spectroscopy (THz-TDS) is a detection method of biological molecules with label-free, non-ionizing, non-intrusive, no pollution and real-time monitoring. But owing to the strong THz absorption by water, it is mainly used in the solid state detection of biological molecules. In this paper, we present a microfluidic chip technique for detecting biological liquid samples using the transmission type of THz-TDS system. The microfluidic channel of the microfluidic chip is fabricated in the quartz glass using Micro-Electro-Mechanical System (MEMS) technology and sealed with polydimethylsiloxane (PDMS) diaphragm. The length, width and depth of the microfluidic channel are 25mm, 100μm and 50μm, respectively. The diameter of THz detection zone in the microfluidic channel is 4mm. The thicknesses of quartz glass and PDMS diaphragm are 1mm and 250μm, individually. Another one of the same quartz glass is used to bond with the PDMS for the rigidity and air tightness of the microfluidic chip. In order to realize the automation of sampling and improve the control precise of fluid, a micropump, which comprises PDMS diaphragm, pump chamber, diffuser and nozzle and flat vibration motor, is integrated on the microfluidic chip. The diffuser and nozzle are fabricated on both sides of the pump chamber, which is covered with PDMS diaphragm. The flat vibration motor is stuck on the PDMS diaphragm as the actuator. We study the terahertz absorption spectroscopy characteristics of glycerol with the concentration of 98% in the microfluidic chip by the aid of the THz-TDS system, and the feasibility of the microfluidic chip for the detection of liquid samples is proved.

  15. Development of a versatile lab-on-a-chip enzyme assay platform for pathogen detection in CBRNE scenarios

    Science.gov (United States)

    Klemm, Richard; Schattschneider, Sebastian; Jahn, Tobias; Hlawatsch, Nadine; Julich, Sandra; Becker, Holger; Gärtner, Claudia

    2013-05-01

    The ability to integrate complete assays on a microfluidic chip helps to greatly simplify instrument requirements and allows the use of lab-on-a-chip technology in the field. A core application for such field-portable systems is the detection of pathogens in a CBRNE scenario such as permanent monitoring of airborne pathogens, e.g. in metro stations or hospitals etc. As one assay methodology for the pathogen identification, enzymatic assays were chosen. In order evaluate different detection strategies, the realized on-chip enzyme assay module has been designed as a general platform chip. In all application cases, the assays are based on immobilized probes located in microfluidic channels. Therefore a microfluidic chip was realized containing a set of three individually addressable channels, not only for detection of the sample itself also to have a set of references for a quantitative analysis. It furthermore includes two turning valves and a waste container for clear and sealed storage of potential pathogenic liquids to avoid contamination of the environment. All liquids remain in the chip and can be disposed of in proper way subsequently to the analysis. The chip design includes four inlet ports consisting of one sample port (Luer interface) and three mini Luer interfaces for fluidic support of e.g. washing buffer, substrate and enzyme solution. The sample can be applied via a special, sealable sampling vessel with integrated female Luer interface. Thereby also pre-anaytical contamination of the environment can be provided. Other reagents that are required for analysis will be stored off chip.

  16. Control Synthesis for the Flow-Based Microfluidic Large-Scale Integration Biochips

    DEFF Research Database (Denmark)

    Minhass, Wajid Hassan; Pop, Paul; Madsen, Jan;

    2013-01-01

    In this paper we are interested in flow-based microfluidic biochips, which are able to integrate the necessary functions for biochemical analysis on-chip. In these chips, the flow of liquid is manipulated using integrated microvalves. By combining severalmicrovalves, more complex units, such...

  17. Infrared vertically-illuminated photodiode for chip alignment feedback

    CERN Document Server

    Alloatti, Luca

    2016-01-01

    We report on vertically-illuminated photodiodes fabricated in the GlobalFoundries 45nm 12SOI node and on a packaging concept for optically-interconnected chips. The photodiodes are responsive at 1180 nm, a wavelength currently used in chip-to-chip communications. They have further a wide field-of-view which enables chip-to-board positional feedback in chip-board assemblies. Monolithic integration enables on-chip processing of the positional data.

  18. Large-scale planar lightwave circuits

    Science.gov (United States)

    Bidnyk, Serge; Zhang, Hua; Pearson, Matt; Balakrishnan, Ashok

    2011-01-01

    By leveraging advanced wafer processing and flip-chip bonding techniques, we have succeeded in hybrid integrating a myriad of active optical components, including photodetectors and laser diodes, with our planar lightwave circuit (PLC) platform. We have combined hybrid integration of active components with monolithic integration of other critical functions, such as diffraction gratings, on-chip mirrors, mode-converters, and thermo-optic elements. Further process development has led to the integration of polarization controlling functionality. Most recently, all these technological advancements have been combined to create large-scale planar lightwave circuits that comprise hundreds of optical elements integrated on chips less than a square inch in size.

  19. Fractal Liquids

    OpenAIRE

    Heinen, Marco; Schnyder, Simon K.; Brady, John F.; Löwen, Hartmut

    2015-01-01

    We introduce fractal liquids by generalizing classical liquids of integer dimensions d=1,2,3 to a fractal dimension df. The particles composing the liquid are fractal objects and their configuration space is also fractal, with the same non-integer dimension. Realizations of our generic model system include microphase separated binary liquids in porous media, and highly branched liquid droplets confined to a fractal polymer backbone in a gel. Here we study the thermodynamics and pair correlati...

  20. Commercial-scale demonstration of the Liquid Phase Methanol (LPMEOH{trademark}) process. Technical progress report number 5, July 1--September 30, 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-31

    The project involves the construction of an 80,000 gallons per day (260 TPD) methanol unit utilizing coal-derived synthesis gas from Eastman`s integrated coal gasification facility. The new equipment consists of synthesis gas feed preparation and compression facilities, the liquid phase reactor and auxiliaries, product distillation facilities, and utilities. The technology to be demonstrated is the product of a cooperative development effort by Air Products and DOE in a program that started in 1981. Developed to enhance electric power generation using integrated gasification combined cycle (IGCC) technology, the LPMEOH{trademark} process is ideally suited for directly processing gases produced by modern-day coal gasifiers. Originally tested at a small, DOE-owned experimental unit in LaPorte, Texas, the technology provides several improvements essential for the economic coproduction of methanol and electricity directly from gasified coal. This liquid phase process suspends fine catalyst particles in an inert liquid, forming a slurry. The slurry dissipates the heat of the chemical reaction away from the catalyst surface, protecting the catalyst and allowing the methanol synthesis reaction to proceed at higher rates.