WorldWideScience

Sample records for chip based generation

  1. Atom chip based generation of entanglement for quantum metrology

    CERN Document Server

    Riedel, Max F; Li, Yun; Hänsch, Theodor W; Sinatra, Alice; Treutlein, Philipp

    2010-01-01

    Atom chips provide a versatile `quantum laboratory on a microchip' for experiments with ultracold atomic gases. They have been used in experiments on diverse topics such as low-dimensional quantum gases, cavity quantum electrodynamics, atom-surface interactions, and chip-based atomic clocks and interferometers. A severe limitation of atom chips, however, is that techniques to control atomic interactions and to generate entanglement have not been experimentally available so far. Such techniques enable chip-based studies of entangled many-body systems and are a key prerequisite for atom chip applications in quantum simulations, quantum information processing, and quantum metrology. Here we report experiments where we generate multi-particle entanglement on an atom chip by controlling elastic collisional interactions with a state-dependent potential. We employ this technique to generate spin-squeezed states of a two-component Bose-Einstein condensate and show that they are useful for quantum metrology. The obser...

  2. Towards third generation pixel readout chips

    Energy Technology Data Exchange (ETDEWEB)

    Garcia-Sciveres, M., E-mail: mgarcia-sciveres@lbl.gov; Mekkaoui, A.; Ganani, D.

    2013-12-11

    We present concepts and prototyping results towards a third generation pixel readout chip. We consider the 130 nm feature size FE-I4 chip, in production for the ATLAS IBL upgrade, to be a second generation chip. A third generation chip would have to go significantly further. A possible direction is to make the IC design generic so that different experiments can configure it to meet significantly different requirements, without the need for everybody to develop their own ASIC from the ground up. In terms of target technology, a demonstrator 500-pixel matrix containing analog front ends only (no complex functionality), was designed and fabricated in 65 nm CMOS and irradiated with protons in December 2011 and May 2012.

  3. Micro-power generator supplying source for integrated circuit chip based on Pb(Sn,Zr,Ti)O3 ferroelectric ceramic

    Science.gov (United States)

    Zhang, Zhenhai; Cui, Zhanzhong; Yan, Jinglong; Li, Kejie

    2011-04-01

    We have demonstrated both experimentally and theoretically that a tin-modified and niobium-modified lead zirconate titanate (Pb(Sn,Zr,Ti)O3) ferroelectric generator system can function as a micro-power supplying source for integrated circuit (IC) chip of separate nonelectric impulse input shock tube digital delay detonator. The ferroelectric ceramic phase transition under transverse shock wave compression can charge an external storage capacitor. The ferroelectric ceramic micro-pulsed-power system is capable of generating low output voltage pulses with an amplitude of 54.2 V and with transferred energy of 1.73 mJ, ultimately supplying an IC chip with micro-power. This work presents the methodology for theoretical analysis and experimental operation of the ferroelectric generator. Theoretical calculations are conducted based on circuit analysis law and principles of dynamic high pressure and shock wave physics. The experimental results were in good agreement with the theoretical analysis.

  4. Optimization of a flexible multi-generation system based on wood chip gasification and methanol production

    DEFF Research Database (Denmark)

    Lythcke-Jørgensen, Christoffer Ernst; Clausen, Lasse Røngaard; Algren, Loui;

    2016-01-01

    with an existing combined heat and power (CHP) unit and industrial energy utility supply in the Danish city of Horsens. The objective was to optimize economic performance and minimize total CO2 emission of the FMG while it was required to meet the local district heating demand plus the thermal utility demand......Flexible multi-generation systems (FMGs) consist of integrated and flexibly operated facilities that providemultiple links between the different sectors of the energy system. The present study treated the design optimization of a conceptual FMG which integrated a methanol-producing biorefinery...... of ± 25% in investment costs and methanol price, and considering two different electricity price scenarios.In addition, a change in the interest rate from 5% to 20% was found to reduce the lower bound of the NPVto 181.3 M€ for reference operating conditions. The results suggest that the applied interest...

  5. A comparison study of on-chip short pulse generation circuits based on a coplanar waveguide

    Institute of Scientific and Technical Information of China (English)

    邹焕; 耿永涛; 王平山; 李家胤

    2011-01-01

    A few traditional pulse-forming circuits are implemented in a commercial 0.13 μm digital complementary-metal-oxide-semiconductor (CMOS) technology. These circuits, based on a coplanar waveguide, are analyzed and compared through CadenceTM Spectre simulati

  6. Optical continuum generation on a silicon chip

    Science.gov (United States)

    Jalali, Bahram; Boyraz, Ozdal; Koonath, Prakash; Raghunathan, Varun; Indukuri, Tejaswi; Dimitropoulos, Dimitri

    2005-08-01

    Although the Raman effect is nearly two orders of magnitude stronger than the electronic Kerr nonlinearity in silicon, under pulsed operation regime where the pulse width is shorter than the phonon response time, Raman effect is suppressed and Kerr nonlinearity dominates. Continuum generation, made possible by the non-resonant Kerr nonlinearity, offers a technologically and economically appealing path to WDM communication at the inter-chip or intra-chip levels. We have studied this phenomenon experimentally and theoretically. Experimentally, a 2 fold spectral broadening is obtained by launching ~4ps optical pulses with 2.2GW/cm2 peak power into a conventional silicon waveguide. Theoretical calculations, that include the effect of two-photon-absorption, free carrier absorption and refractive index change indicate that up to >30 times spectral broadening is achievable in an optimized device. The broadening is due to self phase modulation and saturates due to two photon absorption. Additionally, we find that free carrier dynamics also contributes to the spectral broadening and cause the overall spectrum to be asymmetric with respect to the pump wavelength.

  7. A functional on-chip pressure generator using solid chemical propellant for disposable lab-on-a-chip.

    Science.gov (United States)

    Hong, Chien-Chong; Murugesan, Suresh; Kim, Sanghyo; Beaucage, Gregory; Choi, Jin-Woo; Ahn, Chong H

    2003-11-01

    This paper presents a functional on-chip pressure generator that utilizes chemical energy from a solid chemical propellant to perform fluidic delivery in applications of plastic-based disposable biochips or lab-on-a-chip systems. In this functional on-chip pressure generator, azobis-isobutyronitrile (AIBN) as the solid chemical propellant is deposited on a microheater using a screen-printing technique, which can heat the AIBN at 70 degrees C to produce nitrogen gas. The output pressure of nitrogen gas, generated from the solid chemical propellant, is adjustable to a desired pressure by controlling the input power of the heater. Using this chemical energy source, the generated pressure depends on the deposited amount of the solid chemical propellant and the temperature of the microheater. Experimental measurements show that this functional on-chip pressure generator can achieve around 3 000 Pa pressure when 189 mJ of energy is applied to heat the 100 microg of AIBN. This pressure can drive 50 nl of water through a microfluidic channel of 70 mm and cross-sectional area of 100 microm x 50 microm. Due to its compact size, ease of fabrication and integration, high reliability (no moving parts), biologically inert gas output along with functionality of gas generation, this pressure generator will be an excellent pressure source for handling the fluids of disposable lab-on-a-chip, biochemical analysis systems or drug delivery systems.

  8. Silicon-Chip-Based Optical Frequency Combs

    Science.gov (United States)

    2015-10-26

    frequencies . This phenomenon appears in many systems spanning biology, chemistry, neuroscience, and physics [29,30]. Examples include power grid networks... Frequency Combs," Phys. Rev. Lett. 100, 013902 (2008). [91] F. Leo, et al., “Dispersive wave emission and supercontinuum generation in a silicon wire...AFRL-AFOSR-VA-TR-2015-0365 Silicon-Chip-Based Optical Frequency Combs Alexander Gaeta CORNELL UNIVERSITY Final Report 10/26/2015 DISTRIBUTION A

  9. Towards a Multifunctional Electrochemical Sensing and Niosome Generation Lab-on-Chip Platform Based on a Plug-and-Play Concept

    Directory of Open Access Journals (Sweden)

    Adnane Kara

    2016-05-01

    Full Text Available In this paper, we present a new modular lab on a chip design for multimodal neurotransmitter (NT sensing and niosome generation based on a plug-and-play concept. This architecture is a first step toward an automated platform for an automated modulation of neurotransmitter concentration to understand and/or treat neurodegenerative diseases. A modular approach has been adopted in order to handle measurement or drug delivery or both measurement and drug delivery simultaneously. The system is composed of three fully independent modules: three-channel peristaltic micropumping system, a three-channel potentiostat and a multi-unit microfluidic system composed of pseudo-Y and cross-shape channels containing a miniature electrode array. The system was wirelessly controlled by a computer interface. The system is compact, with all the microfluidic and sensing components packaged in a 5 cm × 4 cm × 4 cm box. Applied to serotonin, a linear calibration curve down to 0.125 mM, with a limit of detection of 31 μ M was collected at unfunctionalized electrodes. Added sensitivity and selectivity was achieved by incorporating functionalized electrodes for dopamine sensing. Electrode functionalization was achieved with gold nanoparticles and using DNA and o-phenylene diamine polymer. The as-configured platform is demonstrated as a central component toward an “intelligent” drug delivery system based on a feedback loop to monitor drug delivery.

  10. Towards a Multifunctional Electrochemical Sensing and Niosome Generation Lab-on-Chip Platform Based on a Plug-and-Play Concept.

    Science.gov (United States)

    Kara, Adnane; Rouillard, Camille; Mathault, Jessy; Boisvert, Martin; Tessier, Frédéric; Landari, Hamza; Melki, Imene; Laprise-Pelletier, Myriam; Boisselier, Elodie; Fortin, Marc-André; Boilard, Eric; Greener, Jesse; Miled, Amine

    2016-05-28

    In this paper, we present a new modular lab on a chip design for multimodal neurotransmitter (NT) sensing and niosome generation based on a plug-and-play concept. This architecture is a first step toward an automated platform for an automated modulation of neurotransmitter concentration to understand and/or treat neurodegenerative diseases. A modular approach has been adopted in order to handle measurement or drug delivery or both measurement and drug delivery simultaneously. The system is composed of three fully independent modules: three-channel peristaltic micropumping system, a three-channel potentiostat and a multi-unit microfluidic system composed of pseudo-Y and cross-shape channels containing a miniature electrode array. The system was wirelessly controlled by a computer interface. The system is compact, with all the microfluidic and sensing components packaged in a 5 cm × 4 cm × 4 cm box. Applied to serotonin, a linear calibration curve down to 0.125 mM, with a limit of detection of 31 μ M was collected at unfunctionalized electrodes. Added sensitivity and selectivity was achieved by incorporating functionalized electrodes for dopamine sensing. Electrode functionalization was achieved with gold nanoparticles and using DNA and o-phenylene diamine polymer. The as-configured platform is demonstrated as a central component toward an "intelligent" drug delivery system based on a feedback loop to monitor drug delivery.

  11. Benchmarking the True Random Number Generator of TPM Chips

    CERN Document Server

    Suciu, Alin

    2010-01-01

    A TPM (trusted platform module) is a chip present mostly on newer motherboards, and its primary function is to create, store and work with cryptographic keys. This dedicated chip can serve to authenticate other devices or to protect encryption keys used by various software applications. Among other features, it comes with a True Random Number Generator (TRNG) that can be used for cryptographic purposes. This random number generator consists of a state machine that mixes unpredictable data with the output of a one way hash function. According the specification it can be a good source of unpredictable random numbers even without having to require a genuine source of hardware entropy. However the specification recommends collecting entropy from any internal sources available such as clock jitter or thermal noise in the chip itself, a feature that was implemented by most manufacturers. This paper will benchmark the random number generator of several TPM chips from two perspectives: the quality of the random bit s...

  12. On-chip generation of heralded photon-number states

    Science.gov (United States)

    Vergyris, Panagiotis; Meany, Thomas; Lunghi, Tommaso; Sauder, Gregory; Downes, James; Steel, M. J.; Withford, Michael J.; Alibart, Olivier; Tanzilli, Sébastien

    2016-01-01

    Beyond the use of genuine monolithic integrated optical platforms, we report here a hybrid strategy enabling on-chip generation of configurable heralded two-photon states. More specifically, we combine two different fabrication techniques, i.e., non-linear waveguides on lithium niobate for efficient photon-pair generation and femtosecond-laser-direct-written waveguides on glass for photon manipulation. Through real-time device manipulation capabilities, a variety of path-coded heralded two-photon states can be produced, ranging from product to entangled states. Those states are engineered with high levels of purity, assessed by fidelities of 99.5 ± 8% and 95.0 ± 8%, respectively, obtained via quantum interferometric measurements. Our strategy therefore stands as a milestone for further exploiting entanglement-based protocols, relying on engineered quantum states, and enabled by scalable and compatible photonic circuits. PMID:27775062

  13. Multimedia-Based Chip Design Education.

    Science.gov (United States)

    Catalkaya, Tamer; Golze, Ulrich

    This paper focuses on multimedia computer-based training programs on chip design. Their development must be fast and economical, in order to be affordable by technical university institutions. The self-produced teaching program Illusion, which demonstrates a monitor controller as an example of a small but complete chip design, was implemented to…

  14. Droplet Microfluidics for Chip-Based Diagnostics

    Directory of Open Access Journals (Sweden)

    Karan V. I. S. Kaler

    2014-12-01

    Full Text Available Droplet microfluidics (DMF is a fluidic handling technology that enables precision control over dispensing and subsequent manipulation of droplets in the volume range of microliters to picoliters, on a micro-fabricated device. There are several different droplet actuation methods, all of which can generate external stimuli, to either actively or passively control the shape and positioning of fluidic droplets over patterned substrates. In this review article, we focus on the operation and utility of electro-actuation-based DMF devices, which utilize one or more micro-/nano-patterned substrates to facilitate electric field-based handling of chemical and/or biological samples. The underlying theory of DMF actuations, device fabrication methods and integration of optical and opto-electronic detectors is discussed in this review. Example applications of such electro-actuation-based DMF devices have also been included, illustrating the various actuation methods and their utility in conducting chip-based laboratory and clinical diagnostic assays.

  15. The next generation of neural network chips

    Energy Technology Data Exchange (ETDEWEB)

    Beiu, V.

    1997-08-01

    There have been many national and international neural networks research initiatives: USA (DARPA, NIBS), Canada (IRIS), Japan (HFSP) and Europe (BRAIN, GALA TEA, NERVES, ELENE NERVES 2) -- just to mention a few. Recent developments in the field of neural networks, cognitive science, bioengineering and electrical engineering have made it possible to understand more about the functioning of large ensembles of identical processing elements. There are more research papers than ever proposing solutions and hardware implementations are by no means an exception. Two fields (computing and neuroscience) are interacting in ways nobody could imagine just several years ago, and -- with the advent of new technologies -- researchers are focusing on trying to copy the Brain. Such an exciting confluence may quite shortly lead to revolutionary new computers and it is the aim of this invited session to bring to light some of the challenging research aspects dealing with the hardware realizability of future intelligent chips. Present-day (conventional) technology is (still) mostly digital and, thus, occupies wider areas and consumes much more power than the solutions envisaged. The innovative algorithmic and architectural ideals should represent important breakthroughs, paving the way towards making neural network chips available to the industry at competitive prices, in relatively small packages and consuming a fraction of the power required by equivalent digital solutions.

  16. Output power enhancement of GaN-based flip-chip light-emitting diodes via conical structures generated by a monolayer of nanospheres

    Science.gov (United States)

    Liu, Mai-Chih; Lin, Chang-Rong; Chan, Chia-Hua

    2016-11-01

    This letter describes the output power enhancement of the GaN-based flip-chip light-emitting diodes (FC LED) featuring conical structures fabricated by etching a self-assembled monolayer SiO2 spheres as the hard mask. By roughening the surface of FC LED components, it increases structural size of the components and elevates the light extraction efficiency of FC LED. At a constant current of 400 mA, the output power of the FC LED with 1200 nm conical structures is 638.1 mW and enhanced by 6.1% compared with the FC LED without surface roughening.

  17. Custom Topology Generation for Network-on-Chip

    DEFF Research Database (Denmark)

    Stuart, Matthias Bo; Sparsø, Jens

    2007-01-01

    This paper compares simulated annealing and tabu search for generating custom topologies for applications with periodic behaviour executing on a network-on-chip. The approach differs from previous work by starting from a fixed mapping of IP-cores to routers and performing design space exploration...

  18. Generation of high-stability solitons at microwave rates on a silicon chip

    CERN Document Server

    Yi, Xu; Yang, Ki Youl; Suh, Myoung-Gyun; Vahala, Kerry

    2015-01-01

    Because they coherently link radio/microwave-rate electrical signals with optical-rate signals derived from lasers and atomic transitions, frequency combs are having a remarkably broad impact on science and technology. Integrating these systems on a photonic chip would revolutionize instrumentation, time keeping, spectroscopy, navigation and potentially create new mass-market applications. A key element of such a system-on-a-chip will be a mode-locked comb that can be self-referenced. The recent demonstration of soliton pulses from a microresonator has placed this goal within reach. However, to provide the requisite link between microwave and optical rate signals soliton generation must occur within the bandwidth of electronic devices. So far this is possible in crytalline devices, but not chip-based devices. Here, a monolithic comb that generates electronic-rate soliton pulses is demonstrated.

  19. On-chip High-Voltage Generator Design

    CERN Document Server

    Tanzawa, Toru

    2013-01-01

    This book describes high-voltage generator design with switched-capacitor multiplier techniques.  The author provides various design techniques for switched-capacitor on-chip high-voltage generators, including charge pump circuits, regulators, level shifters, references, and oscillators.  Readers will see these techniques applied to system design in order to address the challenge of how the on-chip high-voltage generator is designed for Flash memories, LCD drivers, and other semiconductor devices to optimize the entire circuit area and power efficiency with a low voltage supply, while minimizing the cost.   ·         Shows readers how to design charge pump circuits with lower voltage operation, higher power efficiency, and smaller circuit area; ·         Describes comprehensive circuits and systems design of on-chip high-voltage generators; ·         Covers all the component circuit blocks, including charge pumps, pump regulators, level shifters, oscillators, and references.

  20. Towards a new generation of pixel detector readout chips

    CERN Document Server

    Campbell, M; Ballabriga, R.; Frojdh, E.; Heijne, E.; Llopart, X.; Poikela, T.; Tlustos, L.; Valerio, P.; Wong, W.

    2016-01-01

    The Medipix3 Collaboration has broken new ground in spectroscopic X-ray imaging and in single particle detection and tracking. This paper will review briefly the performance and limitations of the present generation of pixel detector readout chips developed by the Collaboration. Through Silicon Via technology has the potential to provide a significant improvement in the tile- ability and more flexibility in the choice of readout architecture. This has been explored in the context of 3 projects with CEA-LETI using Medipix3 and Timepix3 wafers. The next generation of chips will aim to provide improved spectroscopic imaging performance at rates compatible with human CT. It will also aim to provide full spectroscopic images with unprecedented energy and spatial resolution. Some of the opportunities and challenges posed by moving to a more dense CMOS process will be discussed.

  1. On-chip generation and demultiplexing of quantum correlated photons using a silicon-silica monolithic photonic integration platform.

    Science.gov (United States)

    Matsuda, Nobuyuki; Karkus, Peter; Nishi, Hidetaka; Tsuchizawa, Tai; Munro, William J; Takesue, Hiroki; Yamada, Koji

    2014-09-22

    We demonstrate the generation and demultiplexing of quantum correlated photons on a monolithic photonic chip composed of silicon and silica-based waveguides. Photon pairs generated in a nonlinear silicon waveguide are successfully separated into two optical channels of an arrayed-waveguide grating fabricated on a silica-based waveguide platform.

  2. Chip-based quantum key distribution

    Science.gov (United States)

    Sibson, P.; Erven, C.; Godfrey, M.; Miki, S.; Yamashita, T.; Fujiwara, M.; Sasaki, M.; Terai, H.; Tanner, M. G.; Natarajan, C. M.; Hadfield, R. H.; O'Brien, J. L.; Thompson, M. G.

    2017-02-01

    Improvement in secure transmission of information is an urgent need for governments, corporations and individuals. Quantum key distribution (QKD) promises security based on the laws of physics and has rapidly grown from proof-of-concept to robust demonstrations and deployment of commercial systems. Despite these advances, QKD has not been widely adopted, and large-scale deployment will likely require chip-based devices for improved performance, miniaturization and enhanced functionality. Here we report low error rate, GHz clocked QKD operation of an indium phosphide transmitter chip and a silicon oxynitride receiver chip--monolithically integrated devices using components and manufacturing processes from the telecommunications industry. We use the reconfigurability of these devices to demonstrate three prominent QKD protocols--BB84, Coherent One Way and Differential Phase Shift--with performance comparable to state-of-the-art. These devices, when combined with integrated single photon detectors, pave the way for successfully integrating QKD into future telecommunications networks.

  3. Manipulating Neutral Atoms in Chip-Based Magnetic Traps

    Science.gov (United States)

    Aveline, David; Thompson, Robert; Lundblad, Nathan; Maleki, Lute; Yu, Nan; Kohel, James

    2009-01-01

    Several techniques for manipulating neutral atoms (more precisely, ultracold clouds of neutral atoms) in chip-based magnetic traps and atomic waveguides have been demonstrated. Such traps and waveguides are promising components of future quantum sensors that would offer sensitivities much greater than those of conventional sensors. Potential applications include gyroscopy and basic research in physical phenomena that involve gravitational and/or electromagnetic fields. The developed techniques make it possible to control atoms with greater versatility and dexterity than were previously possible and, hence, can be expected to contribute to the value of chip-based magnetic traps and atomic waveguides. The basic principle of these techniques is to control gradient magnetic fields with suitable timing so as to alter a trap to exert position-, velocity-, and/or time-dependent forces on atoms in the trap to obtain desired effects. The trap magnetic fields are generated by controlled electric currents flowing in both macroscopic off-chip electromagnet coils and microscopic wires on the surface of the chip. The methods are best explained in terms of examples. Rather than simply allowing atoms to expand freely into an atomic waveguide, one can give them a controllable push by switching on an externally generated or a chip-based gradient magnetic field. This push can increase the speed of the atoms, typically from about 5 to about 20 cm/s. Applying a non-linear magnetic-field gradient exerts different forces on atoms in different positions a phenomenon that one can exploit by introducing a delay between releasing atoms into the waveguide and turning on the magnetic field.

  4. A concentration gradient generator on a paper-based microfluidic chip coupled with cell culture microarray for high-throughput drug screening.

    Science.gov (United States)

    Hong, Bo; Xue, Peng; Wu, Yafeng; Bao, Jingnan; Chuah, Yon Jin; Kang, Yuejun

    2016-02-01

    Inspired by the paper platforms for 3-D cell culture, a paper-based microfluidic device containing drug concentration gradient was designed and constructed for investigating cell response to drugs based on high throughput analysis. This drug gradient generator was applied to generate concentration gradients of doxorubicin (DOX) as the model drug. HeLa cells encapsulated in collagen hydrogel were incubated in the device reservoirs to evaluate the cell viability based on the controlled release of DOX spatially. It was demonstrated that drug diffusion through the paper fibers created a gradient of drug concentration, which influenced cell viability. This drug screening platform has a great opportunity to be applied for drug discovery and diagnostic studies with simultaneous and parallel tests of drugs under various gradient concentrations.

  5. Chip-based quantum key distribution

    Science.gov (United States)

    Sibson, P.; Erven, C.; Godfrey, M.; Miki, S.; Yamashita, T.; Fujiwara, M.; Sasaki, M.; Terai, H.; Tanner, M. G.; Natarajan, C. M.; Hadfield, R. H.; O'Brien, J. L.; Thompson, M. G.

    2017-01-01

    Improvement in secure transmission of information is an urgent need for governments, corporations and individuals. Quantum key distribution (QKD) promises security based on the laws of physics and has rapidly grown from proof-of-concept to robust demonstrations and deployment of commercial systems. Despite these advances, QKD has not been widely adopted, and large-scale deployment will likely require chip-based devices for improved performance, miniaturization and enhanced functionality. Here we report low error rate, GHz clocked QKD operation of an indium phosphide transmitter chip and a silicon oxynitride receiver chip—monolithically integrated devices using components and manufacturing processes from the telecommunications industry. We use the reconfigurability of these devices to demonstrate three prominent QKD protocols—BB84, Coherent One Way and Differential Phase Shift—with performance comparable to state-of-the-art. These devices, when combined with integrated single photon detectors, pave the way for successfully integrating QKD into future telecommunications networks. PMID:28181489

  6. Mission Profile Based Sizing of IGBT Chip Area for PV Inverter Applications

    DEFF Research Database (Denmark)

    Shen, Yanfeng; Wang, Huai; Yang, Yongheng;

    2016-01-01

    Maximizing the total energy generation is of importance for Photovoltaic (PV) plants. This paper proposes a method to optimize the IGBT chip area for PV inverters to minimize the annual energy loss of the active switches based on long-term operation conditions (i.e., mission profile). The design...... process is firstly introduced. Then the power loss, thermal characteristic and lifetime for IGBT modules with different chip areas are modeled. After that, the dependence of the annual energy loss and maximum junction temperature on the IGBT chip area and switching frequency is derived under a specific...

  7. Continuous cell electroporation for efficient DNA and siRNA delivery based on laminar microfluidic chips.

    Science.gov (United States)

    Wei, Zewen; Li, Zhihong

    2014-01-01

    Electroporation is a high-efficiency and low-toxicity physical gene transfer method. Traditional electroporation is limited to only low volume cell samples. Here we present a continuous cell electroporation method based on commonly used microfluidic chip fabrication technology. Using easily fabricated PDMS microfluidic chip, syringe pumps, and pulse generator, we show efficient delivery of both DNA and siRNA into different cell lines. We describe the protocol of chip fabrication, apparatus setup, and cell electroporation assay. Typically, the fabrication of the devices takes 1 or 2 days and the continuous electroporation assay takes 1 h.

  8. Quantum random number generation using an on-chip plasmonic beamsplitter

    CERN Document Server

    Francis, Jason; Özdemir, Şahin K; Tame, Mark

    2016-01-01

    We report an experimental realisation of a quantum random number generator using a plasmonic beamsplitter. Free-space single photons are converted into propagating single surface plasmon polaritons on a gold stripe waveguide via a grating. The surface plasmons are then guided to a region where they are scattered into one of two possible outputs. The presence of a plasmonic excitation in a given output determines the value of a random bit generated from the quantum scattering process. Using a stream of single surface plasmons injected into the beamsplitter we achieve a quantum random number generation rate of 2.37 Mbits/s even in the presence of loss. We characterise the quality of the random number sequence generated, finding it to be comparable to sequences from other quantum photonic-based devices. The compact nature of our nanophotonic device makes it suitable for tight integration in on-chip applications, such as in quantum computing and communication schemes.

  9. Chip-based droplet sorting

    Science.gov (United States)

    Beer, Neil Reginald; Lee, Abraham; Hatch, Andrew

    2014-07-01

    A non-contact system for sorting monodisperse water-in-oil emulsion droplets in a microfluidic device based on the droplet's contents and their interaction with an applied electromagnetic field or by identification and sorting.

  10. Chip-based droplet sorting

    Energy Technology Data Exchange (ETDEWEB)

    Beer, Neil Reginald; Lee, Abraham; Hatch, Andrew

    2014-07-01

    A non-contact system for sorting monodisperse water-in-oil emulsion droplets in a microfluidic device based on the droplet's contents and their interaction with an applied electromagnetic field or by identification and sorting.

  11. Polystyrene Based SPR Biosensor Chip for Use in Immunoassay

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    Biosensors are widely used in immunoassay.The biosensor chip carries a receptor which is used in immunoassay and the chip properties have an important influence on the detecting sensitivity of the biosensor.This paper describes a polystyrene-based biosensor chip developed and used as part of a surface plasmon resonance (SPR) biosensor.The SPR biosensor has a much higher detecting sensitivity than enzyme-linked immunoserbent assay (ELISA).

  12. Self-Powered Functional Device Using On-Chip Power Generation

    KAUST Repository

    Hussain, Muhammad Mustafa

    2012-01-26

    An apparatus, system, and method for a self-powered device using on-chip power generation. In some embodiments, the apparatus includes a substrate, a power generation module on the substrate, and a power storage module on the substrate. The power generation module may include a thermoelectric generator made of bismuth telluride.

  13. On-Chip Power-Combining for High-Power Schottky Diode Based Frequency Multipliers

    Science.gov (United States)

    Siles Perez, Jose Vicente (Inventor); Chattopadhyay, Goutam (Inventor); Lee, Choonsup (Inventor); Schlecht, Erich T. (Inventor); Jung-Kubiak, Cecile D. (Inventor); Mehdi, Imran (Inventor)

    2015-01-01

    A novel MMIC on-chip power-combined frequency multiplier device and a method of fabricating the same, comprising two or more multiplying structures integrated on a single chip, wherein each of the integrated multiplying structures are electrically identical and each of the multiplying structures include one input antenna (E-probe) for receiving an input signal in the millimeter-wave, submillimeter-wave or terahertz frequency range inputted on the chip, a stripline based input matching network electrically connecting the input antennas to two or more Schottky diodes in a balanced configuration, two or more Schottky diodes that are used as nonlinear semiconductor devices to generate harmonics out of the input signal and produce the multiplied output signal, stripline based output matching networks for transmitting the output signal from the Schottky diodes to an output antenna, and an output antenna (E-probe) for transmitting the output signal off the chip into the output waveguide transmission line.

  14. Modelling and simulation of wood chip combustion in a hot air generator system.

    Science.gov (United States)

    Rajika, J K A T; Narayana, Mahinsasa

    2016-01-01

    This study focuses on modelling and simulation of horizontal moving bed/grate wood chip combustor. A standalone finite volume based 2-D steady state Euler-Euler Computational Fluid Dynamics (CFD) model was developed for packed bed combustion. Packed bed combustion of a medium scale biomass combustor, which was retrofitted from wood log to wood chip feeding for Tea drying in Sri Lanka, was evaluated by a CFD simulation study. The model was validated by the experimental results of an industrial biomass combustor for a hot air generation system in tea industry. Open-source CFD tool; OpenFOAM was used to generate CFD model source code for the packed bed combustion and simulated along with an available solver for free board region modelling in the CFD tool. Height of the packed bed is about 20 cm and biomass particles are assumed to be spherical shape with constant surface area to volume ratio. Temperature measurements of the combustor are well agreed with simulation results while gas phase compositions have discrepancies. Combustion efficiency of the validated hot air generator is around 52.2 %.

  15. WAVELET BASED SPECTRAL CORRELATION METHOD FOR DPSK CHIP RATE ESTIMATION

    Institute of Scientific and Technical Information of China (English)

    Li Yingxiang; Xiao Xianci; Tai Hengming

    2004-01-01

    A wavelet-based spectral correlation algorithm to detect and estimate BPSK signal chip rate is proposed. Simulation results show that the proposed method can correctly estimate the BPSK signal chip rate, which may be corrupted by the quadratic characteristics of the spectral correlation function, in a low SNR environment.

  16. Miniature Bose-Einstein condensate system design based on a transparent atom chip

    Science.gov (United States)

    Cheng, Jun; Li, Xiaolin; Zhang, Jingfang; Xu, Xinping; Jiang, Xiaojun; Zhang, Haichao; Wang, Yuzhu

    2016-08-01

    We propose a new miniature Bose-Einstein condensate (BEC) system based on a transparent atom chip with a compact external coil structure. A standard six-beam macroscopic magneto-optical trap (MOT) is able to be created near the chip surface due to the chip’s transparency. A novel wire pattern consisting of a double-z wire and a z-shaped wire is designed on the transparent atom chip. With a vertical bias magnetic field, the double-z wire can create the quadrupole magnetic field of an intermediate chip MOT, which is suitable for transporting atoms from the macroscopic MOT to the chip z-wire trap efficiently. The compact external coil structure is designed with a rectangular frameless geometry consisting of only four coil pairs and its volume is less than 0.3 liters. The maximum system power consumption during the BEC generation procedure is about 45 W. The miniature system is evaluated, and about 3 × 106 atoms can be loaded into the chip z-wire trap. The miniature chip BEC system has the advantages of small volume and low power consumption, and it has great potential for practical applications of BEC.

  17. Inherent polarization entanglement generated from a monolithic semiconductor chip

    DEFF Research Database (Denmark)

    Horn, Rolf T.; Kolenderski, Piotr; Kang, Dongpeng

    2013-01-01

    Creating miniature chip scale implementations of optical quantum information protocols is a dream for many in the quantum optics community. This is largely because of the promise of stability and scalability. Here we present a monolithically integratable chip architecture upon which is built...... a photonic device primitive called a Bragg reflection waveguide (BRW). Implemented in gallium arsenide, we show that, via the process of spontaneous parametric down conversion, the BRW is capable of directly producing polarization entangled photons without additional path difference compensation, spectral...... as a serious contender on which to build large scale implementations of optical quantum processing devices....

  18. DSP Based Waveform Generator

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The DSP Based Waveform Generator is used for CSR Control system to control special controlled objects, such as the pulsed power supply for magnets, RF system, injection and extraction synchronization, global CSR synchronization etc. This intelligent controller based on 4800 MIPS DSP and 256M SDRAM technology will supply highly stable and highly accurate reference waveform used by the power supply of magnets. The specifications are as follows:

  19. Integration of a Pulse Generator on Chip Into a Compact Ultrawideband Antenna

    NARCIS (Netherlands)

    Vorobyov, A.V.; Bagga, S.; Yarovoy, A.G.; Haddad, S.A.P.; Serdijn, W.A.; Long, J.R.; Irahhauten, Z.; Ligthart, L.P.

    For impulse radio ultrawideband communications an “antenna plus generator” system is co-designed and an on chip generator is integrated into the antenna. This approach does away with the need for intermediate transmission lines conventionally placed between an RF device/generator and an antenna and

  20. Solid state silicon based condenser microphone for hearing aid, has transducer chip and IC chip between intermediate chip and openings on both sides of intermediate chip, to allow sound towards diaphragm

    DEFF Research Database (Denmark)

    2000-01-01

    NOVELTY - A silicon transducer chip (1) has parallel backplate and movable diaphragm (12) and forms an electrical capacitor. The chip and electronic circuit chip (3) are provided on either sides of intermediate chip (2). The chip (2) has openings (4,10) between two sides of the chip, to allow sou...... inlet of microphone. External electrical connection can be made economically reliable and the thermal stress is avoided with the small size solid state silicon based condenser microphone....... towards diaphragm. Surface of the chip (2) has electrical conductors (14) to connect chip with IC chip (3). USE - For use in miniature electroacoustic devices such as hearing aid. ADVANTAGE - Since sound inlet is covered by filter, dust, moisture and other impurities do not obstruct interior and sound...

  1. 3D-SoftChip: A Novel Architecture for Next-Generation Adaptive Computing Systems

    Directory of Open Access Journals (Sweden)

    Lee Mike Myung-Ok

    2006-01-01

    Full Text Available This paper introduces a novel architecture for next-generation adaptive computing systems, which we term 3D-SoftChip. The 3D-SoftChip is a 3-dimensional (3D vertically integrated adaptive computing system combining state-of-the-art processing and 3D interconnection technology. It comprises the vertical integration of two chips (a configurable array processor and an intelligent configurable switch through an indium bump interconnection array (IBIA. The configurable array processor (CAP is an array of heterogeneous processing elements (PEs, while the intelligent configurable switch (ICS comprises a switch block, 32-bit dedicated RISC processor for control, on-chip program/data memory, data frame buffer, along with a direct memory access (DMA controller. This paper introduces the novel 3D-SoftChip architecture for real-time communication and multimedia signal processing as a next-generation computing system. The paper further describes the advanced HW/SW codesign and verification methodology, including high-level system modeling of the 3D-SoftChip using SystemC, being used to determine the optimum hardware specification in the early design stage.

  2. Development of a chip-based ingroove microplasma source: Design, characterization, and diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Li, Xuemei; Meng, Fanying; Yuan, Xin; Yan, Yanyue; Zhao, Zhongjun; Duan, Yixiang, E-mail: yduan@scu.edu.cn [Research Center of Analytical Instrumentation, College of Chemistry and College of Life Science Sichuan University, Chengdu (China); Tang, Jie [State Key Laboratory of Transient Optics and Photonics, Xi' an Institute of Optics and Precision Mechanics of CAS, Xi' an (China)

    2014-03-10

    A chip-based ingroove microplasma source was designed for molecular emission spectrometry by using a space-confined direct current duct in air. The voltage-current characteristics of different size generators, emission spectroscopy of argon were discussed, respectively. It is found that the emission intensity of excited Ar and N{sub 2} approaches its maximum near the cathode, while OH and O peaks most likely appear close to the anode. The electron density, electronic excitation temperature, rotational temperature, and vibrational temperature of the argon plasma were also calculated. More importantly, the chip-based ingroove microplasma shows much better stability compared with its counterparts.

  3. Test of an ME Chip Based on FPGAs

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    The characteristic of FPGA, motion estimation(ME) and the full search block matching arithmetic were introduced, it analyses the collectivity configuration of basic working flow in ME.Based on FPGA, the study concentrates on the control, computing and test part of ME chip implementation.In the end PCB of ME chip is designed and completed.ME is an important link of MPEG standard on picture compression, whose characteristics is its huge amount of data and computing task.So people often use special chip to meet the requirement, but there is still not such production in China at present.

  4. A Microfluidic Chip for Liquid Metal Droplet Generation and Sorting

    Directory of Open Access Journals (Sweden)

    Lu Tian

    2017-01-01

    Full Text Available A liquid metal based microfluidic system was proposed and demonstrated for the generation and sorting of liquid metal droplets. This micro system utilized silicon oil as the continuous phase and Ga66In20.5Sn13.5 (66.0 wt % Ga, 20.5 wt % In, 13.5 wt % Sn, melting point: 10.6 °C as the dispersed phase to generate liquid metal droplets on a three-channel F-junction generator. The F-junction is an updated design similar to the classical T-junction, which has a special branch channel added to a T-junction for the supplement of 30 wt % aqueous NaOH solution. To perform active sorting of liquid metal droplets by dielectrophoresis (DEP, the micro system utilized liquid-metal-filled microchannels as noncontact electrodes to induce electrical fields through the droplet channel. The electrode channels were symmetrically located on both sides of the droplet channel in the same horizontal level. According to the results, the micro system can generate uniformly spherical liquid metal droplets, and control the flow direction of the liquid metal droplets. To better understand the control mechanism, a numerical simulation of the electrical field was performed in detail in this work.

  5. Design of On—Chip Clock Generation with 50/50 Duty Cycle Correction

    Institute of Scientific and Technical Information of China (English)

    HANYueqiu; CUIWei; CHENHe

    2003-01-01

    A circuit design of on-chip clock generation which improves the duty cycle performance and prevents latch-up effect is described.The circuity provides onchip clock with automatic duty cycle correction so as to overcome the shortcoming of clock duty cycle dependence on technology parameters of the traditional on-chip clock generation circuit.It is extremely important that the dynamic power consumption equals approximately the one of its predecessor.The effective performance of the proposed circuit is confirmed by SPICE simulation.

  6. Nonlinear optics at low powers: Alternative mechanism of on-chip optical frequency comb generation

    Science.gov (United States)

    Rogov, Andrei S.; Narimanov, Evgenii E.

    2016-12-01

    Nonlinear optical effects provide a natural way of light manipulation and interaction and form the foundation of applied photonics, from high-speed signal processing and telecommunication to ultrahigh-bandwidth interconnects and information processing. However, relatively weak nonlinear response at optical frequencies calls for operation at high optical powers or boosting efficiency of nonlinear parametric processes by enhancing local-field intensity with high-quality-factor resonators near cavity resonance, resulting in reduced operational bandwidth and increased loss due to multiphoton absorption. We present an alternative to this conventional approach, with strong nonlinear optical effects at low local intensities, based on period-doubling bifurcations near nonlinear cavity antiresonance and apply it to low-power optical frequency comb generation in a silicon chip.

  7. Nonlinear optics at low powers: new mechanism of on-chip optical frequency comb generation

    CERN Document Server

    Rogov, Andrei

    2016-01-01

    Nonlinear optical effects provide a natural way of light manipulation and interaction, and form the foundation of applied photonics -- from high-speed signal processing and telecommunication, to ultra-high bandwidth interconnects and information processing. However, relatively weak nonlinear response at optical frequencies calls for operation at high optical powers, or boosting efficiency of nonlinear parametric processes by enhancing local field intensity with high quality-factor resonators near cavity resonance, resulting in reduced operational bandwidth and increased loss due to multi-photon absorption. Here, we present an alternative to this conventional approach, with strong nonlinear optical effects at substantially lower local intensities, based on period-doubling bifurcations near nonlinear cavity anti-resonance, and apply it to low-power optical comb generation in a silicon chip.

  8. A Novel Chip-based Spectrophotometer for Online Detection

    Institute of Scientific and Technical Information of China (English)

    Haoyuan Cai; Min-Hsien Wu; Zheng Cui

    2006-01-01

    A chip-based spectrophotometer integrated with optical fiber is successfully demonstrated. Grade concentration of lactate solution flowed through the chip to perform an online detection. The response time (100s) and Limit of Detection (LOD,50mg/L) of the device were measured. This device shows comparable performance with traditional commercial instrument,while greatly decreases the sample requirement per detection and reduces the size of total system, introducing a novel method for real-time detection.

  9. Isolation of circulating tumor cells using a microvortex-generating herringbone-chip.

    Science.gov (United States)

    Stott, Shannon L; Hsu, Chia-Hsien; Tsukrov, Dina I; Yu, Min; Miyamoto, David T; Waltman, Belinda A; Rothenberg, S Michael; Shah, Ajay M; Smas, Malgorzata E; Korir, George K; Floyd, Frederick P; Gilman, Anna J; Lord, Jenna B; Winokur, Daniel; Springer, Simeon; Irimia, Daniel; Nagrath, Sunitha; Sequist, Lecia V; Lee, Richard J; Isselbacher, Kurt J; Maheswaran, Shyamala; Haber, Daniel A; Toner, Mehmet

    2010-10-26

    Rare circulating tumor cells (CTCs) present in the bloodstream of patients with cancer provide a potentially accessible source for detection, characterization, and monitoring of nonhematological cancers. We previously demonstrated the effectiveness of a microfluidic device, the CTC-Chip, in capturing these epithelial cell adhesion molecule (EpCAM)-expressing cells using antibody-coated microposts. Here, we describe a high-throughput microfluidic mixing device, the herringbone-chip, or "HB-Chip," which provides an enhanced platform for CTC isolation. The HB-Chip design applies passive mixing of blood cells through the generation of microvortices to significantly increase the number of interactions between target CTCs and the antibody-coated chip surface. Efficient cell capture was validated using defined numbers of cancer cells spiked into control blood, and clinical utility was demonstrated in specimens from patients with prostate cancer. CTCs were detected in 14 of 15 (93%) patients with metastatic disease (median = 63 CTCs/mL, mean = 386 ± 238 CTCs/mL), and the tumor-specific TMPRSS2-ERG translocation was readily identified following RNA isolation and RT-PCR analysis. The use of transparent materials allowed for imaging of the captured CTCs using standard clinical histopathological stains, in addition to immunofluorescence-conjugated antibodies. In a subset of patient samples, the low shear design of the HB-Chip revealed microclusters of CTCs, previously unappreciated tumor cell aggregates that may contribute to the hematogenous dissemination of cancer.

  10. Efficient generation of cluster states with semiconductor double-dot molecules on a chip

    Energy Technology Data Exchange (ETDEWEB)

    Zhou Jian [Anhui Xinhua University, Hefei 230088 (China); Dong Ping, E-mail: dongping9979@163.co [Department of Physics and Electronic Engineering, Hefei Normal University, Hefei 230061 (China); Zou Weiping; Xue Zhengyuan [Laboratory of Quantum Information Technology, ICMP and School of Physics and Telecommunication Engineering, South China Normal University, Guangzhou 510006 (China)

    2011-03-01

    We propose an efficient scheme for the generation of the cluster states directly using the iSWAP gate, with semiconductor double-dot molecules on a chip. The implementation of an iSWAP gate only requires resonant interaction between a molecule and a transmission line resonator, which results in considerable improvement for gate speed comparing to conventional dispersive techniques. Meanwhile, the fast generation speed is also very important in view of decoherence. Therefore, our approach makes one-way quantum computation more feasible via this on chip architecture. -- Research highlights: {yields} An efficient generation scheme of the cluster states is proposed with iSWAP gate in semiconductor double-dot molecules on a chip. {yields} The implementation of an iSWAP gate only requires resonant qubit-resonator interaction, which results in considerable improvement of gate speed comparing to dispersive interaction techniques. {yields} Resonant qubit-resonator interaction results in fast generation, which is very important in view of systematical decoherence. {yields} Our generation approach makes one-way quantum computation more feasible via this on chip architecture.

  11. Droplets actuating chip based on electrowetting-on-dielectric

    Institute of Scientific and Technical Information of China (English)

    WU Jiangang; YUE Ruifeng; ZENG Xuefeng; LIU Litian

    2007-01-01

    A droplet-based actuating chip by using the method of electrowetting-on-dielectric (EWOD)was developed to manipulate the microfluidics.Here,the actuation mechanism of the sandwiched-configuration EWOD chips was carefully studied,and the movement of droplets was numerically analyzed by using the computational fluidic software,CFD-ACE+.The fabrication of the chip,including a heavily phosphorus-doped poly-silicon micro-electrode array and a thermally grown SiO2 dielectric layer,was exploited to improve the chip stability and decrease the actuation voltage.In experiments,the transportation of a deionized droplet of about 0.5 μL is successfully achieved in air by applying the low voltage of 45 V.

  12. Integrated Nanophotonic Silicon Devices for Next Generation Computing Chips

    Science.gov (United States)

    Djordjevic, Stevan

    Development of the computing platform of the future depends largely on high bandwidth interconnects at intra-die level. Silicon photonics, as an innately CMOS compatible technology, is a promising candidate for delivering terabit per second bandwidths through the use of wavelength division multiplex (WDM) signaling. Silicon photonic interconnects offer unmatched bandwidth, density, energy efficiency, latency and reach, compared with the electrical interconnects. WDM silicon photonic links are viewed today as a promising solution for resolving the inter/intra-chip communication bottlenecks for high performance computing systems. Towards its maturity, silicon photonic technology has to resolve the issues of waveguide propagation loss, density of device integration, thermal stability of resonant devices, heterogeneous integration of various materials and many other problems. This dissertation describes the development of integrated photonic technology on silicon and silicon nitride platforms in the increased order of device complexity, from the fabrication process of low loss waveguides and efficient off-chip coupling devices, to the die-size reconfigurable lattice filters for optical signal processing. Particular emphasis of the dissertation is on the demonstration of CMOS-compatible, athermal silicon ring modulators that potentially hold the key to solving the thermal problem of silicon photonic devices. The development of high quality amorphous titanium dioxide films with negative thermo-optic coefficient enabled the fabrication of gigahertz-bandwidth silicon ring modulators that can be made insensitive to ambient temperature changes.

  13. Network-on-chip the next generation of system-on-chip integration

    CERN Document Server

    Kundu, Santanu

    2014-01-01

    ""What makes this book special as compared to the current literature in the field is that it provides a complete picture of NoC architectures. In fact, current books in the context of NoCs are usually specific and presuppose a basic knowledge of NoC architectures. Conversely, this book provides a complete guide for both unskilled readers and researchers working in the area, to acquire not only the basic concepts but also the advanced techniques for improving power, cost and performance metrics of the on-chip communication system.""-Maurizio Palesi, Kore University, Italy.

  14. Low-power chip-level optical interconnects based on bulk-silicon single-chip photonic transceivers

    Science.gov (United States)

    Kim, Gyungock; Park, Hyundai; Joo, Jiho; Jang, Ki-Seok; Kwack, Myung-Joon; Kim, Sanghoon; Kim, In Gyoo; Kim, Sun Ae; Oh, Jin Hyuk; Park, Jaegyu; Kim, Sanggi

    2016-03-01

    We present new scheme for chip-level photonic I/Os, based on monolithically integrated vertical photonic devices on bulk silicon, which increases the integration level of PICs to a complete photonic transceiver (TRx) including chip-level light source. A prototype of the single-chip photonic TRx based on a bulk silicon substrate demonstrated 20 Gb/s low power chip-level optical interconnects between fabricated chips, proving that this scheme can offer compact low-cost chip-level I/O solutions and have a significant impact on practical electronic-photonic integration in high performance computers (HPC), cpu-memory interface, 3D-IC, and LAN/SAN/data-center and network applications.

  15. A Network Traffic Generator Model for Fast Network-on-Chip Simulation

    DEFF Research Database (Denmark)

    Mahadevan, Shankar; Angiolini, Frederico; Storgaard, Michael;

    2005-01-01

    For Systems-on-Chip (SoCs) development, a predominant part of the design time is the simulation time. Performance evaluation and design space exploration of such systems in bit- and cycle-true fashion is becoming prohibitive. We propose a traffic generation (TG) model that provides a fast...

  16. Network Traffic Generator Model for Fast Network-on-Chip Simulation

    DEFF Research Database (Denmark)

    2008-01-01

    For Systems-on-Chip (SoCs) development, a predominant part of the design time is the simulation time. Performance evaluation and design space exploration of such systems in bit- and cycle-true fashion is becoming prohibitive. We propose a traffic generation (TG) model that provides a fast...

  17. Design of One Small Size Photovoltaic Power Generation Monitoring System Based on Single-chip Microcomputer and Labview%一种基于单片机和Labview的小型光伏发电监控系统设计

    Institute of Scientific and Technical Information of China (English)

    吴志强; 田卫华

    2015-01-01

    In this paper,temperature measuring element DS18B20,light sensors PBH1750FVI,wireless trans-mission module nRF24 L01 , high-precision digital potentiometer and electromagnetic relay peripheral modules together with single chip C8051F350 were used to collect temperature, light intensity, voltage and current, which were displayed in the front panel of Labview,and then a real-time photovoltaic power generation data acquisition and control system was developed. The proposed system could improve the limitation of traditional single-chip microcomputer and PC data acquisition processing with many advantages including the simple cir-cuit,low cost,high reliability and friendly man-machine interface which was easy to operate.%利用DS18 B20测温元件、nRF24 L01无线模块、PBH1750 FVI光传感器以及高精度数字电位器和电磁继电器等构成外围模块, C8051 F350单片机通过Labview的VISA串口模块来采集温度、光强、电压、电流,开发了一种实时采集光伏发电数据并对发电状态进行控制的监控系统。该系统改善了传统单片机和PC机数据采集处理的局限和不足,电路简单、成本低、可靠性高,并且具有友好的人机交互界面,便于操作。

  18. NI Based System for Seu Testing of Memory Chips for Avionics

    Directory of Open Access Journals (Sweden)

    Boruzdina Anna

    2016-01-01

    Full Text Available This paper presents the results of implementation of National Instrument based system for Single Event Upset testing of memory chips into neutron generator experimental facility, which used for SEU tests for avionics purposes. Basic SEU testing algorithm with error correction and constant errors detection is presented. The issues of radiation shielding of NI based system are discussed and solved. The examples of experimental results show the applicability of the presented system for SEU memory testing under neutrons influence.

  19. SPIDER: Next Generation Chip Scale Imaging Sensor Update

    Science.gov (United States)

    Duncan, A.; Kendrick, R.; Ogden, C.; Wuchenich, D.; Thurman, S.; Su, T.; Lai, W.; Chun, J.; Li, S.; Liu, G.; Yoo, S. J. B.

    2016-09-01

    The Lockheed Martin Advanced Technology Center (LM ATC) and the University of California at Davis (UC Davis) are developing an electro-optical (EO) imaging sensor called SPIDER (Segmented Planar Imaging Detector for Electro-optical Reconnaissance) that seeks to provide a 10x to 100x size, weight, and power (SWaP) reduction alternative to the traditional bulky optical telescope and focal-plane detector array. The substantial reductions in SWaP would reduce cost and/or provide higher resolution by enabling a larger-aperture imager in a constrained volume. Our SPIDER imager replaces the traditional optical telescope and digital focal plane detector array with a densely packed interferometer array based on emerging photonic integrated circuit (PIC) technologies that samples the object being imaged in the Fourier domain (i.e., spatial frequency domain), and then reconstructs an image. Our approach replaces the large optics and structures required by a conventional telescope with PICs that are accommodated by standard lithographic fabrication techniques (e.g., complementary metal-oxide-semiconductor (CMOS) fabrication). The standard EO payload integration and test process that involves precision alignment and test of optical components to form a diffraction limited telescope is, therefore, replaced by in-process integration and test as part of the PIC fabrication, which substantially reduces associated schedule and cost. This paper provides an overview of performance data on the second-generation PIC for SPIDER developed under the Defense Advanced Research Projects Agency (DARPA)'s SPIDER Zoom research funding. We also update the design description of the SPIDER Zoom imaging sensor and the second-generation PIC (high- and low resolution versions).

  20. Photonic arbitrary waveform generator based on Taylor synthesis method.

    Science.gov (United States)

    Liao, Shasha; Ding, Yunhong; Dong, Jianji; Yan, Siqi; Wang, Xu; Zhang, Xinliang

    2016-10-17

    Arbitrary waveform generation has been widely used in optical communication, radar system and many other applications. We propose and experimentally demonstrate a silicon-on-insulator (SOI) on chip optical arbitrary waveform generator, which is based on Taylor synthesis method. In our scheme, a Gaussian pulse is launched to some cascaded microrings to obtain first-, second- and third-order differentiations. By controlling amplitude and phase of the initial pulse and successive differentiations, we can realize an arbitrary waveform generator according to Taylor expansion. We obtain several typical waveforms such as square waveform, triangular waveform, flat-top waveform, sawtooth waveform, Gaussian waveform and so on. Unlike other schemes based on Fourier synthesis or frequency-to-time mapping, our scheme is based on Taylor synthesis method. Our scheme does not require any spectral disperser or large dispersion, which are difficult to fabricate on chip. Our scheme is compact and capable for integration with electronics.

  1. Beating heart on a chip: a novel microfluidic platform to generate functional 3D cardiac microtissues.

    Science.gov (United States)

    Marsano, Anna; Conficconi, Chiara; Lemme, Marta; Occhetta, Paola; Gaudiello, Emanuele; Votta, Emiliano; Cerino, Giulia; Redaelli, Alberto; Rasponi, Marco

    2016-02-07

    In the past few years, microfluidic-based technology has developed microscale models recapitulating key physical and biological cues typical of the native myocardium. However, the application of controlled physiological uniaxial cyclic strains on a defined three-dimension cellular environment is not yet possible. Two-dimension mechanical stimulation was particularly investigated, neglecting the complex three-dimensional cell-cell and cell-matrix interactions. For this purpose, we developed a heart-on-a-chip platform, which recapitulates the physiologic mechanical environment experienced by cells in the native myocardium. The device includes an array of hanging posts to confine cell-laden gels, and a pneumatic actuation system to induce homogeneous uniaxial cyclic strains to the 3D cell constructs during culture. The device was used to generate mature and highly functional micro-engineered cardiac tissues (μECTs), from both neonatal rat and human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM), strongly suggesting the robustness of our engineered cardiac micro-niche. Our results demonstrated that the cyclic strain was effectively highly uniaxial and uniformly transferred to cells in culture. As compared to control, stimulated μECTs showed superior cardiac differentiation, as well as electrical and mechanical coupling, owing to a remarkable increase in junction complexes. Mechanical stimulation also promoted early spontaneous synchronous beating and better contractile capability in response to electric pacing. Pacing analyses of hiPSC-CM constructs upon controlled administration of isoprenaline showed further promising applications of our platform in drug discovery, delivery and toxicology fields. The proposed heart-on-a-chip device represents a relevant step forward in the field, providing a standard functional three-dimensional cardiac model to possibly predict signs of hypertrophic changes in cardiac phenotype by mechanical and biochemical co-stimulation.

  2. Biphoton statistic of quantum light generated on a silicon chip

    CERN Document Server

    Lu, Xiyuan; Zhang, Jidong; Lin, Qiang

    2016-01-01

    We demonstrate a silicon-chip biphoton source with an unprecedented quantum cross correlation up to ${\\rm g_{si}^{(2)}(0) = (2.58 \\pm 0.16) \\times 10^4}$. The emitted biphotons are intrinsically single-mode, with self correlations of ${\\rm g_{ss}^{(2)}(0) = 1.90 \\pm 0.05}$ and ${\\rm g_{ii}^{(2)}(0) = 1.87 \\pm 0.06}$ for signal and idler photons, respectively. We observe the waveform asymmetry of cross correlation between signal and idler photons and reveal the identical and non-exponential nature of self correlations of individual signal and idler photon modes, which is a nature of cavity-enhanced nonlinear optical processes. The high efficiency and high purity of the biphoton source allow us to herald single photons with a conditional self correlation $\\rm g_{c}^{(2)}(0)$ as low as $\\rm 0.0059 \\pm 0.0014$ at a pair flux of $\\rm 1.95 \\times 10^5$ pairs/s, which remains below $\\rm 0.026 \\pm 0.001$ for a biphoton flux up to $\\rm 2.93 \\times 10^6$ pairs/s, with a photon preparation efficiency in the single-mode ...

  3. Researching and implementation of reconfigurable Hash chip based on FPGA

    Institute of Scientific and Technical Information of China (English)

    Yang Xiaohui; Dai Zibin; Liu Yuanfeng; Wang Ting

    2007-01-01

    The reconfigurable cryptographic chip is an integrated circuit that is designed by means of the method of reconfigurable architecture, and is used for encryption and decryption. Many different cipher algorithms can be flexibly implemented with the aid of a reconfigurable cryptographic chip and can be used in many fields. This article takes an example for the SHA-1/224/256 algorithms, and then designs a reconfigurable cryptographic chip based on the thought and method of the reconfigurable architecture. Finally, this paper gives the implementation result based on the FPGA of the family of Stratix II of Altera Corporation, and presents a good research trend for resolving the storage in hardware implementation using FPGAs.

  4. Generation of ultrafast pulse via combined effects of stimulated Raman scattering and non-degenerate two-photon absorption in silicon nanophotonic chip

    Indian Academy of Sciences (India)

    Jianwei Wu; Fengguang Luo; Mingcui Cao

    2009-04-01

    A project of ultrafast pulse generation has been presented and demonstrated by utilizing the combined nonlinear effects of stimulated Raman scattering (SRS) and non-degenerate two-photon absorption (TPA) based on silicon nanophotonic chip, in which a continuous wave (CW) and an ultrafast dark pulse are co-propagating in the silicon chip so that the CW will be modulated inversely by the dark pulse during the propagation. As a result, an ultrafast bright pulse is achieved using the technique. Simulation results show that an ultrafast pulse with a pulsewidth (full-width at half-maximum (FWHM)) of about 50 fs is generated at the end of a 5-mm long silicon chip, when the initial conditions, including an input maximum of 0.5 W and FWHM of ∼ 176 fs for dark pulse, and CW with power of 5 W, are chosen.

  5. On-chip high-voltage generator design design methodology for charge pumps

    CERN Document Server

    Tanzawa, Toru

    2016-01-01

    This book provides various design techniques for switched-capacitor on-chip high-voltage generators, including charge pump circuits, regulators, level shifters, references, and oscillators.  Readers will see these techniques applied to system design in order to address the challenge of how the on-chip high-voltage generator is designed for Flash memories, LCD drivers, and other semiconductor devices to optimize the entire circuit area and power efficiency with a low voltage supply, while minimizing the cost.  This new edition includes a variety of useful updates, including coverage of power efficiency and comprehensive optimization methodologies for DC-DC voltage multipliers, modeling of extremely low voltage Dickson charge pumps, and modeling and optimum design of AC-DC switched-capacitor multipliers for energy harvesting and power transfer for RFID.

  6. Controlling the spectrum of photons generated on a silicon nanophotonic chip

    Science.gov (United States)

    Kumar, Ranjeet; Ong, Jun Rong; Savanier, Marc; Mookherjea, Shayan

    2014-11-01

    Directly modulated semiconductor lasers are widely used, compact light sources in optical communications. Semiconductors can also be used to generate nonclassical light; in fact, CMOS-compatible silicon chips can be used to generate pairs of single photons at room temperature. Unlike the classical laser, the photon-pair source requires control over a two-dimensional joint spectral intensity (JSI) and it is not possible to process the photons separately, as this could destroy the entanglement. Here we design a photon-pair source, consisting of planar lightwave components fabricated using CMOS-compatible lithography in silicon, which has the capability to vary the JSI. By controlling either the optical pump wavelength, or the temperature of the chip, we demonstrate the ability to select different JSIs, with a large variation in the Schmidt number. Such control can benefit high-dimensional communications where detector-timing constraints can be relaxed by realizing a large Schmidt number in a small frequency range.

  7. Apparatus, System, and Method for On-Chip Thermoelectricity Generation

    KAUST Repository

    Hussain, Muhammad Mustafa

    2012-01-26

    An apparatus, system, and method for a thermoelectric generator. In some embodiments, the thermoelectric generator comprises a first thermoelectric region and a second thermoelectric region, where the second thermoelectric region may be coupled to the first thermoelectric region by a first conductor. In some embodiments, a second conductor may be coupled to the first thermoelectric region and a third conductor may be coupled to the second thermoelectric region. In some embodiments, the first conductor may be in a first plane, the first thermoelectric region and the second thermoelectric region may be in a second plane, and the second conductor and the third conductor may be in a third plane.

  8. World-to-chip microfluidic interface with built-in valves for multichamber chip-based PCR assays.

    Science.gov (United States)

    Oh, Kwang W; Park, Chinsung; Namkoong, Kak; Kim, Jintae; Ock, Kyeong-Sik; Kim, Suhyeon; Kim, Young-A; Cho, Yoon-Kyoung; Ko, Christopher

    2005-08-01

    We report a practical world-to-chip microfluidic interfacing method with built-in valves suitable for microscale multichamber chip-based assays. One of the primary challenges associated with the successful commercialization of fully integrated microfluidic systems has been the lack of reliable world-to-chip microfluidic interconnections. After sample loading and sealing, leakage tests were conducted at 100 degrees C for 30 min and no detectable leakage flows were found during the test for 100 microchambers. To demonstrate the utility of our world-to-chip microfluidic interface, we designed a microscale PCR chip with four chambers and performed PCR assays. The PCR results yielded a 100% success rate with no contamination or leakage failures. In conclusion, we have introduced a simple and inexpensive microfluidic interfacing system for both sample loading and sealing with no dead volume, no leakage flow and biochemical compatibility.

  9. Pattern Based Graph Generator

    CERN Document Server

    Shuai, Hong-Han; Yu, Philip S; Shen, Chih-Ya; Chen, Ming-Syan

    2013-01-01

    The importance of graph mining has been widely recognized thanks to a large variety of applications in many areas, while real datasets always play important roles to examine the solution quality and efficiency of a graph mining algorithm. Nevertheless, the size of a real dataset is usually fixed and constrained according to the available resources, such as the efforts to crawl an on-line social network. In this case, employing a synthetic graph generator is a possible way to generate a massive graph (e.g., billions nodes) for evaluating the scalability of an algorithm, and current popular statistical graph generators are properly designed to maintain statistical metrics such as total node degree, degree distribution, diameter, and clustering coefficient of the original social graphs. Nevertheless, in addition to the above metrics, recent studies on graph mining point out that graph frequent patterns are also important to provide useful implications for the corresponding social networking applications, but thi...

  10. Chip electrophoresis of gelatin-based nanoparticles.

    Science.gov (United States)

    Weiss, Victor U; Lehner, Angela; Grombe, Ringo; Marchetti-Deschmann, Martina; Allmaier, Günter

    2013-08-01

    Recently, biodegradable nanoparticles received increasing attention for pharmaceutical applications as well as applications in the food industry. With the current investigation we demonstrate chip electrophoresis of fluorescently (FL) labeled gelatin nanoparticles (gelatin NPs) on a commercially available instrument. FL labeling included a step for the removal of low molecular mass material (especially excess dye molecules). Nevertheless, for the investigated gelatin NP preparation two analyte peaks, one very homogeneous with an electrophoretic net mobility of μ = -24.6 ± 0.3 × 10(-9) m(2) /Vs at the peak apex (n = 17) and another more heterogeneous peak with μ between approximately -27.2 ± 0.2 × 10(-9) m(2) /Vs and -36.6 ± 0.2 × 10(-9) m(2) /Vs at the peak beginning and end point (n = 11, respectively) were recorded. Filtration allowed enrichment of particles in the size range of approximately 35 nm (pore size employed for concentration of gelatin NPs) to 200 nm (pore size employed during FL labeling). This corresponded to the very homogeneous peak linking it to gelatin NPs, whereas the more heterogeneous peak probably corresponds to gelatin not cross-linked to such a high degree (NP building blocks). Several further gelatin NP preparations were analyzed according to the same protocol yielding peaks with electrophoretic net mobilities between -23.3 ± 0.3 × 10(-9) m(2) /Vs and -28.9 ± 0.2 × 10(-9) m(2) /Vs at peak apexes (n = 15 and 6). Chip electrophoresis allows analyte separation in less than two minutes (including electrophoretic sample injection). Together with the high sensitivity of the FL detection - the LOD as derived for the first main peak of the applied dye from the threefold standard deviation of the background noise values 80 pM for determined separation conditions - this leads to a very promising high throughput separation technique especially for the analysis of bionanoparticles. For gelatin NP preparations, chip electrophoresis

  11. Heart-on-a-chip based on stem cell biology.

    Science.gov (United States)

    Jastrzebska, Elzbieta; Tomecka, Ewelina; Jesion, Iwona

    2016-01-15

    Heart diseases are one of the main causes of death around the world. The great challenge for scientists is to develop new therapeutic methods for these types of ailments. Stem cells (SCs) therapy could be one of a promising technique used for renewal of cardiac cells and treatment of heart diseases. Conventional in vitro techniques utilized for investigation of heart regeneration do not mimic natural cardiac physiology. Lab-on-a-chip systems may be the solution which could allow the creation of a heart muscle model, enabling the growth of cardiac cells in conditions similar to in vivo conditions. Microsystems can be also used for differentiation of stem cells into heart cells, successfully. It will help better understand of proliferation and regeneration ability of these cells. In this review, we present Heart-on-a-chip systems based on cardiac cell culture and stem cell biology. This review begins with the description of the physiological environment and the functions of the heart. Next, we shortly described conventional techniques of stem cells differentiation into the cardiac cells. This review is mostly focused on describing Lab-on-a-chip systems for cardiac tissue engineering. Therefore, in the next part of this article, the microsystems for both cardiac cell culture and SCs differentiation into cardiac cells are described. The section about SCs differentiation into the heart cells is divided in sections describing biochemical, physical and mechanical stimulations. Finally, we outline present challenges and future research concerning Heart-on-a-chip based on stem cell biology.

  12. VLSI architecture of leading eigenvector generation for on-chip principal component analysis spike sorting system.

    Science.gov (United States)

    Chen, Tung-Chien; Liu, Wentai; Chen, Liang-Gee

    2008-01-01

    On-chip spike detection and principal component analysis (PCA) sorting hardware in an integrated multi-channel neural recording system is highly desired to ease the bandwidth bottleneck from high-density microelectrode array implanted in the cortex. In this paper, we propose the first leading eigenvector generator, the key hardware module of PCA, to enable the whole framework. Based on the iterative eigenvector distilling algorithm, the proposed flipped structure enables the low cost and low power implementation by discarding the division and square root hardware units. Further, the proposed adaptive level shifting scheme optimizes the accuracy and area trade off by dynamically increasing the quantization parameter according to the signal level.With the specification of four principal components/channel, 32 samples/spike, and nine bits/sample, the proposed hardware can train 312 channels per minute with 1MHz operation frequency. 0.13 mm(2) silicon area and 282microW power consumption are required in 90 nm 1P9M CMOS process.

  13. Example based painting generation

    Institute of Scientific and Technical Information of China (English)

    GUO Yan-wen; YU Jin-hui; XU Xiao-dong; WANG Jin; PENG Qun-sheng

    2006-01-01

    We present an approach for generating paintings on photographic images with the style encoded by the example paintings and adopt representative brushes extracted from the example paintings as the painting primitives. Our system first divides the given photographic image into several regions on which we synthesize a grounding layer with texture patches extracted from the example paintings. Then, we paint those regions using brushes stochastically chosen from the brush library, with further brush color and shape perturbations. The brush direction is determined by a direction field either constructed by a convenient user interactive manner or synthesized from the examples. Our approach offers flexible and intuitive user control over the painting process and style.

  14. Chip-Scale Continuously Tunable Optical Orbital Angular Momentum Generator

    CERN Document Server

    Sun, Jie; Moresco, Michele; Coolbaugh, Douglas; Watts, Michael R

    2014-01-01

    Light carrying orbital angular momentum (OAM) has potential to impact a wide variety of applications ranging from optical communications to quantum information and optical forces for the excitation and manipulation of atoms, molecules, and micro-particles. The unique advantage of utilizing OAM in these applications relies, to a large extent, on the use of multiple different OAM states. Therefore, it is desirable to have a device that is able to gen- erate light with freely adjustable OAM states in an integrated form for large- scale integration. We propose and demonstrate a compact silicon photonic integrated circuit to generate a free-space optical beam with OAM state con- tinuously tuned from a single electrical input signal, realizing both integer and non-integer OAM states. The compactness and flexibility of the device and its compatibility with complementary metal-oxide-semiconductor (CMOS) pro- cessing hold promise for integration with other silicon photonic components for wide-ranging applications.

  15. Lab-on-a-Chip Based Protein Crystallization

    Science.gov (United States)

    vanderWoerd, Mark J.; Brasseur, Michael M.; Spearing, Scott F.; Whitaker, Ann F. (Technical Monitor)

    2001-01-01

    We are developing a novel technique with which we will grow protein crystals in very small volumes, utilizing chip-based, microfluidic ("LabChip") technology. This development, which is a collaborative effort between NASA's Marshall Space Flight Center and Caliper Technologies Corporation, promises a breakthrough in the field of protein crystal growth. Our initial results obtained from two model proteins, Lysozyme and Thaumatin, show that it is feasible to dispense and adequately mix protein and precipitant solutions on a nano-liter scale. The mixtures have shown crystal growth in volumes in the range of 10 nanoliters to 5 microliters. In addition, large diffraction quality crystals were obtained by this method. X-ray data from these crystals were shown to be of excellent quality. Our future efforts will include the further development of protein crystal growth with LabChip(trademark) technology for more complex systems. We will initially address the batch growth method, followed by the vapor diffusion method and the liquid-liquid diffusion method. The culmination of these chip developments is to lead to an on orbit protein crystallization facility on the International Space Station. Structural biologists will be invited to utilize the on orbit Iterative Biological Crystallization facility to grow high quality macromolecular crystals in microgravity.

  16. Development of Microreactor Array Chip-Based Measurement System for Massively Parallel Analysis of Enzymatic Activity

    Science.gov (United States)

    Hosoi, Yosuke; Akagi, Takanori; Ichiki, Takanori

    Microarray chip technology such as DNA chips, peptide chips and protein chips is one of the promising approaches for achieving high-throughput screening (HTS) of biomolecule function since it has great advantages in feasibility of automated information processing due to one-to-one indexing between array position and molecular function as well as massively parallel sample analysis as a benefit of down-sizing and large-scale integration. Mostly, however, the function that can be evaluated by such microarray chips is limited to affinity of target molecules. In this paper, we propose a new HTS system of enzymatic activity based on microreactor array chip technology. A prototype of the automated and massively parallel measurement system for fluorometric assay of enzymatic reactions was developed by the combination of microreactor array chips and a highly-sensitive fluorescence microscope. Design strategy of microreactor array chips and an optical measurement platform for the high-throughput enzyme assay are discussed.

  17. Metadata based mediator generation

    Energy Technology Data Exchange (ETDEWEB)

    Critchlow, T

    1998-03-01

    Mediators are a critical component of any data warehouse, particularly one utilizing partially materialized views; they transform data from its source format to the warehouse representation while resolving semantic and syntactic conflicts. The close relationship between mediators and databases, requires a mediator to be updated whenever an associated schema is modified. This maintenance may be a significant undertaking if a warehouse integrates several dynamic data sources. However, failure to quickly perform these updates significantly reduces the reliability of the warehouse because queries do not have access to the m current data. This may result in incorrect or misleading responses, and reduce user confidence in the warehouse. This paper describes a metadata framework, and associated software designed to automate a significant portion of the mediator generation task and thereby reduce the effort involved in adapting the schema changes. By allowing the DBA to concentrate on identifying the modifications at a high level, instead of reprogramming the mediator, turnaround time is reduced and warehouse reliability is improved.

  18. A step towards on-chip biochemical energy cascade of microorganisms: carbon dioxide generation induced by ethanol fermentation in 3D printed modular lab-on-a-chip

    Science.gov (United States)

    Podwin, A.; Kubicki, W.; Adamski, K.; Walczak, R.; Dziuban, J. A.

    2016-11-01

    The concept of biochemical energy cascade of microorganisms towards oxygen generation in 3D printed lab-on-a-chip has been presented. In this work, carbon dioxide - a product of ethanol fermentation of yeasts has been utilized to enable light-initialized photosynthesis of euglenas and as a result of their metabolic transitions produce pure oxygen.

  19. Engineered peptide-based nanobiomaterials for electrochemical cell chip

    Science.gov (United States)

    Kafi, Md. Abdul; Cho, Hyeon-Yeol; Choi, Jeong-Woo

    2016-07-01

    Biomaterials having cell adhesion ability are considered to be integral part of a cell chip. A number of researches have been carried out to search for a suitable material for effective immobilization of cell on substrate. Engineered ECM materials or their components like collagen, Poly- l-Lysine (PLL), Arg-Gly-Asp (RGD) peptide have been extensively used for mammalian cell adhesion and proliferation with the aim of tissue regeneration or cell based sensing application. This review focuses on the various approaches for two- and three-dimensionally patterned nanostructures of a short peptide i.e. RGD peptide on chip surfaces together with their effects on cell behaviors and electrochemical measurements. Most of the study concluded with positive remarks on the well-oriented engineered RGD peptide over their homogenous thin film. The engineered RGD peptide not only influences cell adhesion, spreading and proliferation but also their periodic nano-arrays directly influence electrochemical measurements of the chips. The electrochemical signals found to be enhanced when RGD peptides were used in well-defined two-dimensional nano-arrays. The topographic alteration of three-dimensional structure of engineered RGD peptide was reported to be suitably contacted with the integrin receptors of cellular membrane which results indicated the enhanced cell-electrode adhesion and efficient electron exchange phenomenon. This enhanced electrochemical signal increases the sensitivity of the chip against the target analytes. Therefore, development of engineered cellular recognizable peptides and its 3D topological design for fabrication of cell chip will provide the synergetic effect on bio-affinity, sensitivity and accuracy for the in situ real-time monitoring of analytes.

  20. Demonstration of a Chip-based Nonlinear Optical Isolator

    CERN Document Server

    Hua, Shiyue; Jiang, Xiaoshun; Hua, Qian; Jiang, Liang; Xiao, Min

    2016-01-01

    Despite fundamentally challenging in integrated (nano)photonics, achieving chip-based light nonreciprocity becomes increasingly urgent in signal processing and optical communications. Because of material incompatibilities in conventional approaches based on Faraday effects, alternative solutions have resorted to nonlinear processes to obtain one-way transmission. However, revealed dynamic reciprocity in a recent theoretical analysis has pinned down the functionalities of these nonlinear isolators. To overcome this dynamic reciprocity, we here report the first demonstration of a nonlinear optical isolator on a silicon chip enforced by phase-matched parametric amplification. Using a high-Q microtoroid resonator, we realize highly nonreciprocal transport at the 1,550 nm wavelength when waves are simultaneously launched in both forward and backward directions. Our design, compatible with current CMOS technique, yields convincing isolation performance with sufficiently low insertion loss for a wide range of input ...

  1. An Aluminum Microfluidic Chip Fabrication Using a Convenient Micromilling Process for Fluorescent Poly(DL-lactide-co-glycolide Microparticle Generation

    Directory of Open Access Journals (Sweden)

    Wan-Chen Hsieh

    2012-02-01

    Full Text Available This study presents the development of a robust aluminum-based microfluidic chip fabricated by conventional mechanical micromachining (computer numerical control-based micro-milling process. It applied the aluminum-based microfluidic chip to form poly(lactic-co-glycolic acid (PLGA microparticles encapsulating CdSe/ZnS quantum dots (QDs. A cross-flow design and flow-focusing system were employed to control the oil-in-water (o/w emulsification to ensure the generation of uniformly-sized droplets. The size of the droplets could be tuned by adjusting the flow rates of the water and oil phases. The proposed microfluidic platform is easy to fabricate, set up, organize as well as program, and is valuable for further applications under harsh reaction conditions (high temperature and/or strong organic solvent systems. The proposed method has the advantages of actively controlling the droplet diameter, with a narrow size distribution, good sphericity, as well as being a simple process with a high throughput. In addition to the fluorescent PLGA microparticles in this study, this approach can also be applied to many applications in the pharmaceutical and biomedical area.

  2. A superhydrophobic chip based on SU-8 photoresist pillars suspended on a silicon nitride membrane.

    Science.gov (United States)

    Marinaro, Giovanni; Accardo, Angelo; De Angelis, Francesco; Dane, Thomas; Weinhausen, Britta; Burghammer, Manfred; Riekel, Christian

    2014-10-01

    We developed a new generation of superhydrophobic chips optimized for probing ultrasmall sample quantities by X-ray scattering and fluorescence techniques. The chips are based on thin Si3N4 membranes with a tailored pattern of SU-8 photoresist pillars. Indeed, aqueous solution droplets can be evaporated and concentrated at predefined positions using a non-periodic pillar pattern. We demonstrated quantitatively the deposition and aggregation of gold glyconanoparticles from the evaporation of a nanomolar droplet in a small spot by raster X-ray nanofluorescence. Further, raster nanocrystallography of biological objects such as rod-like tobacco mosaic virus nanoparticles reveals crystalline macro-domain formation composed of highly oriented nanorods.

  3. A superhydrophobic chip based on SU-8 photoresist pillars suspended on a silicon nitride membrane

    KAUST Repository

    Marinaro, Giovanni

    2014-07-28

    We developed a new generation of superhydrophobic chips optimized for probing ultrasmall sample quantities by X-ray scattering and fluorescence techniques. The chips are based on thin Si3N4 membranes with a tailored pattern of SU-8 photoresist pillars. Indeed, aqueous solution droplets can be evaporated and concentrated at predefined positions using a non-periodic pillar pattern. We demonstrated quantitatively the deposition and aggregation of gold glyconanoparticles from the evaporation of a nanomolar droplet in a small spot by raster X-ray nanofluorescence. Further, raster nanocrystallography of biological objects such as rod-like tobacco mosaic virus nanoparticles reveals crystalline macro-domain formation composed of highly oriented nanorods. © 2014 the Partner Organisations.

  4. High Speed Terahertz Modulator on the Chip Based on Tunable Terahertz Slot Waveguide

    Science.gov (United States)

    Singh, P. K.; Sonkusale, S.

    2017-01-01

    This paper presents an on-chip device that can perform gigahertz-rate amplitude modulation and switching of broadband terahertz electromagnetic waves. The operation of the device is based on the interaction of confined THz waves in a novel slot waveguide with an electronically tunable two dimensional electron gas (2DEG) that controls the loss of the THz wave propagating through this waveguide. A prototype device is fabricated which shows THz intensity modulation of 96% at 0.25 THz carrier frequency with low insertion loss and device length as small as 100 microns. The demonstrated modulation cutoff frequency exceeds 14 GHz indicating potential for the high-speed modulation of terahertz waves. The entire device operates at room temperature with low drive voltage (power consumption. The device architecture has potential for realization of the next generation of on-chip modulators and switches at THz frequencies.

  5. Mass spectrometric detection of short-lived drug metabolites generated in an electrochemical microfluidic chip.

    Science.gov (United States)

    van den Brink, Floris T G; Büter, Lars; Odijk, Mathieu; Olthuis, Wouter; Karst, Uwe; van den Berg, Albert

    2015-02-03

    The costs of drug development have been rising exponentially over the last six decades, making it essential to select drug candidates in the early drug discovery phases before proceeding to expensive clinical trials. Here, we present novel screening methods using an electrochemical chip coupled online to mass spectrometry (MS) or liquid chromatography (LC) and MS, to generate phase I and phase II drug metabolites and to demonstrate protein modification by reactive metabolites. The short transit time (∼4.5 s) between electrochemical oxidation and mass spectrometric detection, enabled by an integrated electrospray emitter, allows us to detect a short-lived radical metabolite of chlorpromazine which is too unstable to be detected using established test routines. In addition, a fast way to screen candidate drugs is established by recording real-time mass voltammograms, which allows one to identify the drug metabolites that are expected to be formed upon oxidation by applying a linear potential sweep and simultaneously detect oxidation products. Furthermore, detoxification of electrochemically generated reactive metabolites of paracetamol was mimicked by their adduct formation with the antioxidant glutathione. Finally, the potential toxicity of reactive metabolites can be investigated by the modification of proteins, which was demonstrated by modification of carbonic anhydrase I with electrochemically generated reactive metabolites of paracetamol. With this series of experiments, we demonstrate the potential of this electrochemical chip as a complementary tool for a variety of drug metabolism studies in the early stages of drug discovery.

  6. The gut microbiotassay – a high-throughput real-time PCR chip combined with next generation sequencing

    DEFF Research Database (Denmark)

    Hermann-Bank, Marie Louise; Skovgaard, Kerstin; Mølbak, Lars

    this assay with the high-throughput real-time PCR chip “Access Array 48.48” from Fluidigm. The chip executes 2304 individual reactions in parallel and afterwards it is possible to harvest the amplicons for next-generation sequencing. This approach gives a taxonomical overview of the gut microbiota, hence...... generation sequencing both provides a quantitative measure in terms of Cq-values achieved from the real-time PCR, as well as the deeper information obtained from next-generation sequencing of the amplicons. It is quick to perform and offers a high-throughput at a relatively low cost. These features make...

  7. A Microfluidic Chip Using Phenol Formaldehyde Resin for Uniform-Sized Polycaprolactone and Chitosan Microparticle Generation

    Directory of Open Access Journals (Sweden)

    Wan-Chen Hsieh

    2013-06-01

    Full Text Available This study develops a new solvent-compatible microfluidic chip based on phenol formaldehyde resin (PFR. In addition to its solvent-resistant characteristics, this microfluidic platform also features easy fabrication, organization, decomposition for cleaning, and reusability compared with conventional chips. Both solvent-dependent (e.g., polycaprolactone and nonsolvent-dependent (e.g., chitosan microparticles were successfully prepared. The size of emulsion droplets could be easily adjusted by tuning the flow rates of the dispersed/continuous phases. After evaporation, polycaprolactone microparticles ranging from 29.3 to 62.7 μm and chitosan microparticles ranging from 215.5 to 566.3 μm were obtained with a 10% relative standard deviation in size. The proposed PFR microfluidic platform has the advantages of active control of the particle size with a narrow size distribution as well as a simple and low cost process with a high throughput.

  8. Novel definition files for human GeneChips based on GeneAnnot

    Directory of Open Access Journals (Sweden)

    Ferrari Sergio

    2007-11-01

    Full Text Available Abstract Background Improvements in genome sequence annotation revealed discrepancies in the original probeset/gene assignment in Affymetrix microarray and the existence of differences between annotations and effective alignments of probes and transcription products. In the current generation of Affymetrix human GeneChips, most probesets include probes matching transcripts from more than one gene and probes which do not match any transcribed sequence. Results We developed a novel set of custom Chip Definition Files (CDF and the corresponding Bioconductor libraries for Affymetrix human GeneChips, based on the information contained in the GeneAnnot database. GeneAnnot-based CDFs are composed of unique custom-probesets, including only probes matching a single gene. Conclusion GeneAnnot-based custom CDFs solve the problem of a reliable reconstruction of expression levels and eliminate the existence of more than one probeset per gene, which often leads to discordant expression signals for the same transcript when gene differential expression is the focus of the analysis. GeneAnnot CDFs are freely distributed and fully compliant with Affymetrix standards and all available software for gene expression analysis. The CDF libraries are available from http://www.xlab.unimo.it/GA_CDF, along with supplementary information (CDF libraries, installation guidelines and R code, CDF statistics, and analysis results.

  9. Fabrication method for chip-scale-vacuum-packages based on a chip-to-wafer-process

    Science.gov (United States)

    Bauer, J.; Weiler, D.; Ruß, M.; Heß, J.; Yang, P.; Voß, J.; Arnold, N.,; Vogt, H.

    2010-10-01

    This paper introduces a simple vacuum packaging method which is based on a Chip-to-Wafer process. The MEMS-device is provided with an electroplated solder frame. A Si-lid with the same solder frame is mounted on each die of the wafer using a flip chip process. The same materials for lid and substrate are used in order to reduce the mechanical stress due to the same thermal coefficients of expansion. The resulting cavity between die and lid can be evacuated and hermetically sealed with an eutectic soldering process. The feasibility of the method is demonstrated with an infrared focal plane array (IR-FPA). In this case, the Si-lid acts as an optical window and contains an anti reflective layer for the 8-14 μm wavelength area on both sides. The long-term vacuum stability is supported by a getter film inside the package. This method simplifies the sawing process and has the additional cost benefit that it is possible to package only known good dies.

  10. Characterizing Rat PNS Electrophysiological Response to Electrical Stimulation Using in vitro Chip-Based Human Investigational Platform (iCHIP)

    Energy Technology Data Exchange (ETDEWEB)

    Khani, Joshua [Georgetown Univ., Washington, DC (United States); Prescod, Lindsay [Georgetown Univ., Washington, DC (United States); Enright, Heather [Georgetown Univ., Washington, DC (United States); Felix, Sarah [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Osburn, Joanne [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Wheeler, Elizabeth [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Kulp, Kris [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-08-18

    Ex vivo systems and organ-on-a-chip technology offer an unprecedented approach to modeling the inner workings of the human body. The ultimate goal of LLNL’s in vitro Chip-based Human Investigational Platform (iCHIP) is to integrate multiple organ tissue cultures using microfluidic channels, multi-electrode arrays (MEA), and other biosensors in order to effectively simulate and study the responses and interactions of the major organs to chemical and physical stimulation. In this study, we focused on the peripheral nervous system (PNS) component of the iCHIP system. Specifically we sought to expound on prior research investigating the electrophysiological response of rat dorsal root ganglion cells (rDRGs) to chemical exposures, such as capsaicin. Our aim was to establish a protocol for electrical stimulation using the iCHIP device that would reliably elicit a characteristic response in rDRGs. By varying the parameters for both the stimulation properties – amplitude, phase width, phase shape, and stimulation/ return configuration – and the culture conditions – day in vitro and neural cell types - we were able to make several key observations and uncover a potential convention with a minimal number of devices tested. Future work will seek to establish a standard protocol for human DRGs in the iCHIP which will afford a portable, rapid method for determining the effects of toxins and novel therapeutics on the PNS.

  11. Magnetohydrodynamic-based Laboratories on a Chip for Analysis of Biomolecules Project

    Data.gov (United States)

    National Aeronautics and Space Administration — A laboratory-on-a-chip design based on magnetohydrodynamic (MHD) microfluidics and integrated microelectrochemical detection is proposed. The proposed device is...

  12. Microfluidic interface technology based on stereolithography for glass-based lab-on-a-chips.

    Science.gov (United States)

    Han, Song-I; Han, Ki-Ho

    2013-01-01

    As lab-on-a-chips are developed for on-chip integrated microfluidic systems with multiple functions, the development of microfluidic interface (MFI) technology to enable integration of complex microfluidic systems becomes increasingly important and faces many technical difficulties. Such difficulties include the need for more complex structures, the possibility of biological or chemical cross-contamination between functional compartments, and the possible need for individual compartments fabricated from different substrate materials. This chapter introduces MFI technology, based on rapid stereolithography, for a glass-based miniaturized genetic sample preparation system, as an example of a complex lab-on-a-chip that could include functional elements such as; solid-phase DNA extraction, polymerase chain reaction, and capillary electrophoresis. To enable the integration of a complex lab-on-a-chip system in a single chip, MFI technology based on stereolithography provides a simple method for realizing complex arrangements of one-step plug-in microfluidic interconnects, integrated microvalves for microfluidic control, and optical windows for on-chip optical processes.

  13. Field programmable gate array–based servo control integrated chip for a six-axis articulated robot manipulator

    Directory of Open Access Journals (Sweden)

    Ying-Shieh Kung

    2016-05-01

    Full Text Available The objective of this article is to build a field programmable gate array–based six-axis servo control integrated chip which can integrate the function of a motion trajectory planning and the function of six position/speed/current servo controllers into one integrated chip. In the work, first, a mathematical modeling of a robot manipulator with the actuator using permanent magnet synchronous motor is derived. Second, the proportional controller in the position loop, a proportional–integral controller in the speed loop and a vector controller in the current loop for each axis are applied. Third, a system on a programmable chip technology which comprises an Altera field programmable gate array chip and an embedded soft-core Nios-II processor is considered to develop the proposed servo control integrated chip. However, in the servo control integrated chip, it has two modules. The first module is an embedded soft-core Nios-II processor which is used to generate the motion trajectory planning by software. The second module presents a six-axis servo controller intellectual property by hardware which is applied to execute six position/speed/current controllers. Therefore, the function of a motion trajectory command and the function of six position/speed/current servo controllers for a six-axis robot manipulator can be integrated into one field programmable gate array. Finally, to verify the effectiveness and correctness of the proposed field programmable gate array–based servo control integrated chip, a six-axis robot manipulator is applied and some experimental results are demonstrated.

  14. Design of a Tunable All-Digital UWB Pulse Generator CMOS Chip for Wireless Endoscope.

    Science.gov (United States)

    Chul Kim; Nooshabadi, S

    2010-04-01

    A novel tunable all-digital, ultrawideband pulse generator (PG) has been implemented in a standard 0.18-¿ m complementary metal-oxide semiconductor (CMOS) process for implantable medical applications. The chip shows that an ultra-low dynamic energy consumption of 27 pJ per pulse without static current flow at a 200-MHz pulse repetition frequency (PRF) with a 1.8-V power supply and low area of 90 × 50 ¿m(2). The PG generates tunable pulsewidth, amplitude, and transmit (Tx) power by using simple circuitry, through precise timing control of the H-bridge output stage. The all-digital architecture allows easy integration into a standard CMOS process, thus making it the most suitable candidate for in-vivo biotelemetry applications.

  15. An integrated one-chip-sensor system for microRNA quantitative analysis based on digital droplet polymerase chain reaction

    Science.gov (United States)

    Tsukuda, Masahiko; Wiederkehr, Rodrigo Sergio; Cai, Qing; Majeed, Bivragh; Fiorini, Paolo; Stakenborg, Tim; Matsuno, Toshinobu

    2016-04-01

    A silicon microfluidic chip was developed for microRNA (miRNA) quantitative analysis. It performs sequentially reverse transcription and polymerase chain reaction in a digital droplet format. Individual processes take place on different cavities, and reagent and sample mixing is carried out on a chip, prior to entering each compartment. The droplets are generated on a T-junction channel before the polymerase chain reaction step. Also, a miniaturized fluorescence detector was developed, based on an optical pick-up head of digital versatile disc (DVD) and a micro-photomultiplier tube. The chip integrated in the detection system was tested using synthetic miRNA with known concentrations, ranging from 300 to 3,000 templates/µL. Results proved the functionality of the system.

  16. Chip based electroanalytical systems for cell analysis

    DEFF Research Database (Denmark)

    Spegel, C.; Heiskanen, A.; Skjolding, L.H.D.

    2008-01-01

    This review with 239 references has as its aim to give the reader an introduction to the kinds of methods used for developing microchip based electrode systems as well as to cover the existing literature on electroanalytical systems where microchips play a crucial role for 'nondestructive...

  17. Narrow linewidth Brillouin laser based on chalcogenide photonic chip

    CERN Document Server

    Kabakova, Irina V; Choi, Duk-Yong; Debbarma, Sukhanta; Luther-Davies, Barry; Madden, Stephen J; Eggleton, Benjamin J

    2013-01-01

    We present the first demonstration of a narrow linewidth, waveguide-based Brillouin laser which is enabled by large Brillouin gain of a chalcogenide chip. The waveguides are equipped with vertical tapers for low loss coupling. Due to optical feedback for the Stokes wave, the lasing threshold is reduced to 360 mW, which is 5 times lower than the calculated single-pass Brillouin threshold for the same waveguide. The slope efficiency of the laser is found to be 30% and the linewidth of 100 kHz is measured using a self-heterodyne method.

  18. Design, fabrication and characterization of drug delivery systems based on lab-on-a-chip technology.

    Science.gov (United States)

    Nguyen, Nam-Trung; Shaegh, Seyed Ali Mousavi; Kashaninejad, Navid; Phan, Dinh-Tuan

    2013-11-01

    Lab-on-a-chip technology is an emerging field evolving from the recent advances of micro- and nanotechnologies. The technology allows the integration of various components into a single microdevice. Microfluidics, the science and engineering of fluid flow in microscale, is the enabling underlying concept for lab-on-a-chip technology. The present paper reviews the design, fabrication and characterization of drug delivery systems based on this amazing technology. The systems are categorized and discussed according to the scales at which the drug is administered. Starting with the fundamentals on scaling laws of mass transfer and basic fabrication techniques, the paper reviews and discusses drug delivery devices for cellular, tissue and organism levels. At the cellular level, a concentration gradient generator integrated with a cell culture platform is the main drug delivery scheme of interest. At the tissue level, the synthesis of smart particles as drug carriers using lab-on-a-chip technology is the main focus of recent developments. At the organism level, microneedles and implantable devices with fluid-handling components are the main drug delivery systems. For drug delivery to a small organism that can fit into a microchip, devices similar to those of cellular level can be used.

  19. Development of gold based solder candidates for flip chip assembly

    DEFF Research Database (Denmark)

    Chidambaram, Vivek; Hald, John; Hattel, Jesper Henri

    2009-01-01

    Flip chip technology is now rapidly replacing the traditional wire bonding interconnection technology in the first level packaging applications due to the miniaturization drive in the microelectronics industry. Flip chip assembly currently involves the use of high lead containing solders for inte......Flip chip technology is now rapidly replacing the traditional wire bonding interconnection technology in the first level packaging applications due to the miniaturization drive in the microelectronics industry. Flip chip assembly currently involves the use of high lead containing solders...

  20. Micromotor-based energy generation.

    Science.gov (United States)

    Singh, Virendra V; Soto, Fernando; Kaufmann, Kevin; Wang, Joseph

    2015-06-01

    A micromotor-based strategy for energy generation, utilizing the conversion of liquid-phase hydrogen to usable hydrogen gas (H2), is described. The new motion-based H2-generation concept relies on the movement of Pt-black/Ti Janus microparticle motors in a solution of sodium borohydride (NaBH4) fuel. This is the first report of using NaBH4 for powering micromotors. The autonomous motion of these catalytic micromotors, as well as their bubble generation, leads to enhanced mixing and transport of NaBH4 towards the Pt-black catalytic surface (compared to static microparticles or films), and hence to a substantially faster rate of H2 production. The practical utility of these micromotors is illustrated by powering a hydrogen-oxygen fuel cell car by an on-board motion-based hydrogen and oxygen generation. The new micromotor approach paves the way for the development of efficient on-site energy generation for powering external devices or meeting growing demands on the energy grid.

  1. Photonic arbitrary waveform generator based on Taylor synthesis method

    DEFF Research Database (Denmark)

    Liao, Shasha; Ding, Yunhong; Dong, Jianji

    2016-01-01

    Arbitrary waveform generation has been widely used in optical communication, radar system and many other applications. We propose and experimentally demonstrate a silicon-on-insulator (SOI) on chip optical arbitrary waveform generator, which is based on Taylor synthesis method. In our scheme......, a Gaussian pulse is launched to some cascaded microrings to obtain first-, second- and third-order differentiations. By controlling amplitude and phase of the initial pulse and successive differentiations, we can realize an arbitrary waveform generator according to Taylor expansion. We obtain several typical...... waveforms such as square waveform, triangular waveform, flat-top waveform, sawtooth waveform, Gaussian waveform and so on. Unlike other schemes based on Fourier synthesis or frequency-to-time mapping, our scheme is based on Taylor synthesis method. Our scheme does not require any spectral disperser or large...

  2. Polymer-based chips for surface plasmon resonance sensors

    Science.gov (United States)

    Obreja, Paula; Cristea, Dana; Kusko, Mihai; Dinescu, Adrian

    2008-06-01

    This paper presents a design and low-cost techniques for polymer-based chips for surface plasmon resonance (SPR) sensors. To obtain a polymer chip with a prism, microchannels and a chamber at microscale dimensions, replication techniques in polymers with controlled refractive index have been developed. Photoresist, polydimethylsiloxane (PDMS), polymethylmethacrylate (PMMA) and epoxy resin were used. Silicon dioxide/silicon-based molds have been obtained by anisotropic etching of silicon, and glass prisms were used as masters for replication. The photoresist molds were obtained by optical lithography and were used to obtain the microchannels and the chamber. A liquid prepolymer (PDMS, Sylgard 184) with curing agent at a ratio of 10:1 was used, and a special technique was developed in order to fabricate the components of the structure at the same time. For the deposition and direct patterning of the metallic layers onto the polymer surface, different methods were experimented with, including sputtering. The materials and techniques used to achieve SPR sensors are presented, and the possibilities and limitations of the technology are discussed.

  3. Glucose sensing by waveguide-based absorption spectroscopy on a silicon chip

    OpenAIRE

    2014-01-01

    In this work, we demonstrate in vitro detection of glucose by means of a lab-on-chip absorption spectroscopy approach. This optical method allows label-free and specific detection of glucose. We show glucose detection in aqueous glucose solutions in the clinically relevant concentration range with a silicon-based optofluidic chip. The sample interface is a spiral-shaped rib waveguide integrated on a silicon-on-insulator (SOI) photonic chip. This SOI chip is combined with micro-fluidics in pol...

  4. A microfluidic chip for generating reactive plasma at gas-gas interface formed in laminar flow

    Science.gov (United States)

    Hashimoto, Masahiro; Tsukasaki, Katsuki; Kumagai, Shinya; Sasaki, Minoru

    2015-01-01

    A gas-gas interface is used for generating a localized reactive plasma flow at an atmospheric pressure. A microfluidic chip is fabricated as the reactor integrating a small plasma source located upstream. Within a Y-shaped microchannel, a discharging gas flows with a chemical gas. Owing to the small width of the microchannel, the gas flow is stabilized in a laminar flow. The resultant gas-gas interface is formed in the area where two gases flow facing each other activating the chemical gas through the energetic species in the discharging gas. A characteristic stream pattern is observed as the etching profile of a carbon film with a sub-µm sharp step change that can be explained by the spatial distribution of the reactive oxygen. This etching profile is different from that obtained when plasma discharging occurs near the channel exit being affected by the turbulent flow.

  5. Design of Three-Phase Sine Wave Generator Based on Single-Chip Microcomputer%基于单片机的三相正弦波发生器设计

    Institute of Scientific and Technical Information of China (English)

    吴兴波; 贾彬彬; 赵亮

    2012-01-01

    The design of waveform generator based on MSP430F169 is describe, which produces three-phase sinusoidal wave with phase difference of each others 120 °. The basic principle is depositing the sine-wave data in the MCU in advance, then the internal DAC0 and DAC1 are controled to update the output by the internal timers as the sine-wave data. The A phase and B phase we have got constitute the C phase basing on the principle that the instantaneous value of three-phase alternating current is zero. Amplitude and frequency are adjustable. Amplitude can be enlarged through the programmable amplifier.and freauencv is set bv the MCU%介绍了基于MSP430F169单片机的波形发生器,产生相位差互为120°的三相正弦波.基本原理是将正弦波数据预先存入单片机,利用单片机定时器来控制片内DAC0和DACl两路数模转换模块按所存数据更新输出,发出A相和B相正弦波,依据三相交流电瞬时值之和为零的原理合成C相正弦波.幅值、频率均可调,幅值通过程控放大器放大,频率通过单片机设定.

  6. Nondestructive diagnosis of flip chips based on vibration analysis using PCA-RBF

    Science.gov (United States)

    Su, Lei; Shi, Tielin; Liu, Zhiping; Zhou, Hongdi; Du, Li; Liao, Guanglan

    2017-02-01

    Flip chip technology combined with solder bump interconnection has been widely applied in IC package. The solder bumps are sandwiched between dies and substrates, leading to conventional techniques being difficult to diagnose the flip chips. Meanwhile, these conventional diagnosis methods are usually performed by human visual judgment. The human eye-fatigue can easily cause fault detection. Thus, it is difficult and crucial to detect the defects of flip chips automatically. In this paper, a nondestructive diagnosis system based on vibration analysis is proposed. The flip chip is excited by air-coupled ultrasounds and raw vibration signals are measured by a laser scanning vibrometer. Forty-two features are extracted for analysis, including ten time domain features, sixteen frequency domain features and sixteen wavelet packet energy features. Principal component analysis is used for feature reduction. Radial basis function neural network is adopted for classification and recognition. Flip chips in three states (good flip chips, flip chips with missing solder bumps and flip chips with open solder bumps) are utilized to validate the proposed method. The results demonstrate that this method is effective for defect inspection in flip chip package.

  7. Plasma cell treatment device Plasma-on-Chip: Monitoring plasma-generated reactive species in microwells

    Science.gov (United States)

    Oh, Jun-Seok; Kojima, Shinya; Sasaki, Minoru; Hatta, Akimitsu; Kumagai, Shinya

    2017-01-01

    We have developed a plasma cell treatment device called Plasma-on-Chip that enables the real-time monitoring of a single cell culture during plasma treatment. The device consists of three parts: 1) microwells for cell culture, 2) a microplasma device for generating reactive oxygen and nitrogen species (RONS) for use in cell treatment, and 3) through-holes (microchannels) that connect each microwell with the microplasma region for RONS delivery. Here, we analysed the delivery of the RONS to the liquid culture medium stored in the microwells. We developed a simple experimental set-up using a microdevice and applied in situ ultraviolet absorption spectroscopy with high sensitivity for detecting RONS in liquid. The plasma-generated RONS were delivered into the liquid culture medium via the through-holes fabricated into the microdevice. The RONS concentrations were on the order of 10–100 μM depending on the size of the through-holes. In contrast, we found that the amount of dissolved oxygen was almost constant. To investigate the process of RONS generation, we numerically analysed the gas flow in the through-holes. We suggest that the circulating gas flow in the through-holes promotes the interaction between the plasma (ionised gas) and the liquid, resulting in enhanced RONS concentrations. PMID:28176800

  8. Embedded 3D Graphics Core for FPGA-based System-on-Chip Applications

    DEFF Research Database (Denmark)

    Holten-Lund, Hans Erik

    2005-01-01

    This paper presents a 3D graphics accelerator core for an FPGA based system, and illustrates how to build a System-on-Chip containing a Xilinx MicroBlaze soft-core CPU and our 3D graphics accelerator core. The system is capable of running uClinux and hardware accelerated 3D graphics applications...... consumption is reduced as well. We show how an FPGA based embedded system is capable of most tasks in a single chip solution, without requiring additional CPU or graphics chips....

  9. Quantum-correlated photon pairs generated in a commercial 45nm complementary metal-oxide semiconductor microelectronics chip

    CERN Document Server

    Gentry, Cale M; Wade, Mark W; Stevens, Martin J; Dyer, Shellee D; Zeng, Xiaoge; Pavanello, Fabio; Gerrits, Thomas; Nam, Sae Woo; Mirin, Richard P; Popović, Miloš A

    2015-01-01

    Correlated photon pairs are a fundamental building block of quantum photonic systems. While pair sources have previously been integrated on silicon chips built using customized photonics manufacturing processes, these often take advantage of only a small fraction of the established techniques for microelectronics fabrication and have yet to be integrated in a process which also supports electronics. Here we report the first demonstration of quantum-correlated photon pair generation in a device fabricated in an unmodified advanced (sub-100nm) complementary metal-oxide-semiconductor (CMOS) process, alongside millions of working transistors. The microring resonator photon pair source is formed in the transistor layer structure, with the resonator core formed by the silicon layer typically used for the transistor body. With ultra-low continuous-wave on-chip pump powers ranging from 5 $\\mu$W to 400 $\\mu$W, we demonstrate pair generation rates between 165 Hz and 332 kHz using >80% efficient WSi superconducting nano...

  10. Energy Harvesting Chip and the Chip Based Power Supply Development for a Wireless Sensor Network

    Directory of Open Access Journals (Sweden)

    Dasheng Lee

    2008-12-01

    Full Text Available In this study, an energy harvesting chip was developed to scavenge energy from artificial light to charge a wireless sensor node. The chip core is a miniature transformer with a nano-ferrofluid magnetic core. The chip embedded transformer can convert harvested energy from its solar cell to variable voltage output for driving multiple loads. This chip system yields a simple, small, and more importantly, a battery-less power supply solution. The sensor node is equipped with multiple sensors that can be enabled by the energy harvesting power supply to collect information about the human body comfort degree. Compared with lab instruments, the nodes with temperature, humidity and photosensors driven by harvested energy had variation coefficient measurement precision of less than 6% deviation under low environmental light of 240 lux. The thermal comfort was affected by the air speed. A flow sensor equipped on the sensor node was used to detect airflow speed. Due to its high power consumption, this sensor node provided 15% less accuracy than the instruments, but it still can meet the requirement of analysis for predicted mean votes (PMV measurement. The energy harvesting wireless sensor network (WSN was deployed in a 24-hour convenience store to detect thermal comfort degree from the air conditioning control. During one year operation, the sensor network powered by the energy harvesting chip retained normal functions to collect the PMV index of the store. According to the one month statistics of communication status, the packet loss rate (PLR is 2.3%, which is as good as the presented results of those WSNs powered by battery. Referring to the electric power records, almost 54% energy can be saved by the feedback control of an energy harvesting sensor network. These results illustrate that, scavenging energy not only creates a reliable power source for electronic devices, such as wireless sensor nodes, but can also be an energy source by building an

  11. Detection of On-Chip Generated Weak Microwave Radiation Using Superconducting Normal-Metal SET

    Directory of Open Access Journals (Sweden)

    Behdad Jalali-Jafari

    2016-01-01

    Full Text Available The present work addresses quantum interaction phenomena of microwave radiation with a single-electron tunneling system. For this study, an integrated circuit is implemented, combining on the same chip a Josephson junction (Al/AlO x /Al oscillator and a single-electron transistor (SET with the superconducting island (Al and normal-conducting leads (AuPd. The transistor is demonstrated to operate as a very sensitive photon detector, sensing down to a few tens of photons per second in the microwave frequency range around f ∼ 100 GHz. On the other hand, the Josephson oscillator, realized as a two-junction SQUID and coupled to the detector via a coplanar transmission line (Al, is shown to provide a tunable source of microwave radiation: controllable variations in power or in frequency were accompanied by significant changes in the detector output, when applying magnetic flux or adjusting the voltage across the SQUID, respectively. It was also shown that the effect of substrate-mediated phonons, generated by our microwave source, on the detector output was negligibly small.

  12. Robust Quantum Random Number Generator Based on Avalanche Photodiodes

    Science.gov (United States)

    Wang, Fang-Xiang; Wang, Chao; Chen, Wei; Wang, Shuang; Lv, Fu-Sheng; He, De-Yong; Yin, Zhen-Qiang; Li, Hong-Wei; Guo, Guang-Can; Han, Zheng-Fu

    2015-08-01

    We propose and demonstrate a scheme to realize a high-efficiency truly quantum random number generator (RNG) at room temperature (RT). Using an effective extractor with simple time bin encoding method, the avalanche pulses of avalanche photodiode (APD) are converted into high-quality random numbers (RNs) that are robust to slow varying noise such as fluctuations of pulse intensity and temperature. A light source is compatible but not necessary in this scheme. Therefor the robustness of the system is effective enhanced. The random bits generation rate of this proof-of-principle system is 0.69 Mbps with double APDs and 0.34 Mbps with single APD. The results indicate that a high-speed RNG chip based on the scheme is potentially available with an integrable APD array.

  13. Simultaneous detection of lactate and glucose by integrated printed circuit board based array sensing chip

    Energy Technology Data Exchange (ETDEWEB)

    Li, Xuelian [Institute for Clean Energy and Advanced Materials, Southwest University, Chongqing 400715 (China); School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715 (China); Zang, Jianfeng [Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708 (United States); Liu, Yingshuai; Lu, Zhisong [Institute for Clean Energy and Advanced Materials, Southwest University, Chongqing 400715 (China); Li, Qing, E-mail: Qli@swu.edu.cn [School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715 (China); Li, Chang Ming, E-mail: ecmli@swu.edu.cn [Institute for Clean Energy and Advanced Materials, Southwest University, Chongqing 400715 (China)

    2013-04-10

    Highlights: ► An integrated printed circuit board (PCB) based array sensing chip was developed. ► Simultaneous detection of lactate and glucose in serum has been demonstrated. ► The array electronic biochip has high signal to noise ratio and high sensitivity. ► Additional electrodes were designed on the chip to correct interferences. -- Abstract: An integrated printed circuit board (PCB) based array sensing chip was developed to simultaneously detect lactate and glucose in mouse serum. The novelty of the chip relies on a concept demonstration of inexpensive high-throughput electronic biochip, a chip design for high signal to noise ratio and high sensitivity by construction of positively charged chitosan/redox polymer Polyvinylimidazole-Os (PVI-Os)/carbon nanotube (CNT) composite sensing platform, in which the positively charged chitosan/PVI-Os is mediator and electrostatically immobilizes the negatively charged enzyme, while CNTs function as an essential cross-linker to network PVI-Os and chitosan due to its negative charged nature. Additional electrodes on the chip with the same sensing layer but without enzymes were prepared to correct the interferences for high specificity. Low detection limits of 0.6 μM and 5 μM were achieved for lactate and glucose, respectively. This work could be extended to inexpensive array sensing chips with high sensitivity, good specificity and high reproducibility for various sensor applications.

  14. Continuous Sensing Photonic Lab-on-a-Chip Platform Based on Cross-Linked Enzyme Crystals.

    Science.gov (United States)

    Conejero-Muriel, Mayte; Rodríguez-Ruiz, Isaac; Verdugo-Escamilla, Cristóbal; Llobera, Andreu; Gavira, José A

    2016-12-06

    Microfluidics or lab-on-a-chip technology offer clear advantages over conventional systems such as a dramatic reduction of reagent consumption or a shorter analysis time, which are translated into cost-effective systems. In this work, we present a photonic enzymatic lab-on-a-chip reactor based on cross-linked enzyme crystals (CLECs), able to work in continuous flow, as a highly sensitive, robust, reusable, and stable platform for continuous sensing with superior performance as compared to the state of the art. The microreactor is designed to facilitate the in situ crystallization and crystal cross-linking generating enzymatically active material that can be stored for months/years. Thus, and by means of monolithically integrated micro-optics elements, continuous enzymatic reactions can be spectrophotometrically monitored. Lipase, an enzyme with industrial significance for catalyzed transesterification, hydrolysis, and esterification reactions, is used to demonstrate the potential of the microplatforms as both a continuous biosensor and a microreactor for the synthesis of high value compounds.

  15. On-Chip Built-in Jitter Measurement Circuit for PLL Based on Duty-Cycle Modulation Vernier Delay Line

    Institute of Scientific and Technical Information of China (English)

    YU Fei; Chung Len Lee; ZHANG Jingkai

    2007-01-01

    Phase-locked loops (PLLs) are essential wherever a local event is synchronized with a periodic external event. They are utilized as on-chip clock frequency generators to synthesize a low skew and higher internal frequency clock from an external lower frequency signal and its characterization and measurement have recently been calling for more and more attention. In this paper, a built-in on-chip circuit for measuring jitter of PLL based on a duty cycle modulation vernier delay line is proposed and demonstrated. The circuit employs two delay lines to measure the timing difference and transform the difference signal into digital words. The vernier lines are composed of delay cells whose duty cycle can be adjusted by a feedback voltage. It enables the circuit to have a self calibration capability which eliminates the mismatch problem caused by the process variation.

  16. A system-on-chip and paper-based inkjet printed electrodes for a hybrid wearable bio-sensing system.

    Science.gov (United States)

    Xie, Li; Yang, Geng; Mäntysalo, Matti; Jonsson, Fredrik; Zheng, Li-Rong

    2012-01-01

    This paper presents a hybrid wearable bio-sensing system, which combines traditional small-area low-power and high-performance System-on-Chip (SoC), flexible paper substrate and cost-effective Printed Electronics. Differential bio-signals are measured, digitized, stored and transmitted by the SoC. The total area of the chip is 1.5 × 3.0 mm(2). This enables the miniaturization of the wearable system. The electrodes and interconnects are inkjet printed on paper substrate and the performance is verified in in-vivo tests. The quality of electrocardiogram signal sensed by printed electrodes is comparable with commercial electrodes, with noise level slightly increased. The paper-based inkjet printed system is flexible, light and thin, which makes the final system comfortable for end-users. The hybrid bio-sensing system offers a potential solution to the next generation wearable healthcare technology.

  17. Neural network predicts sequence of TP53 gene based on DNA chip

    DEFF Research Database (Denmark)

    Spicker, J.S.; Wikman, F.; Lu, M.L.;

    2002-01-01

    We have trained an artificial neural network to predict the sequence of the human TP53 tumor suppressor gene based on a p53 GeneChip. The trained neural network uses as input the fluorescence intensities of DNA hybridized to oligonucleotides on the surface of the chip and makes between zero...... and four errors in the predicted 1300 bp sequence when tested on wild-type TP53 sequence....

  18. Phase-Matched Second-Harmonic Generation in an On-Chip Li NbO 3 Microresonator

    Science.gov (United States)

    Lin, Jintian; Xu, Yingxin; Ni, Jielei; Wang, Min; Fang, Zhiwei; Qiao, Lingling; Fang, Wei; Cheng, Ya

    2016-07-01

    The realization of an efficient nonlinear parametric process in microresonators is a challenging issue largely because of an inherent difficulty in simultaneously ensuring the phase-matching condition and a coherent multiple-resonance condition for all the waves participating in the nonlinear conversion process. Here, we demonstrate highly efficient second-harmonic generation in an on-chip LiNbO3 microresonator fabricated by femtosecond-laser direct writing. We overcome the above difficulty by selectively exciting high-order modes in the fabricated thin-disk microresonator. Thanks to the low optical absorption and high nonlinear optical coefficient of LiNbO3 crystal, we achieve a normalized conversion efficiency of 1.106 ×10-3/mW in the on-chip LiNbO3 microdisk with a diameter of approximately 102 μ m .

  19. Micromotor-based lab-on-chip immunoassays

    Science.gov (United States)

    García, Miguel; Orozco, Jahir; Guix, Maria; Gao, Wei; Sattayasamitsathit, Sirilak; Escarpa, Alberto; Merkoçi, Arben; Wang, Joseph

    2013-01-01

    Here we describe the first example of using self-propelled antibody-functionalized synthetic catalytic microengines for capturing and transporting target proteins between the different reservoirs of a lab-on-a-chip (LOC) device. A new catalytic polymer/Ni/Pt microtube engine, containing carboxy moieties on its mixed poly(3,4-ethylenedioxythiophene) (PEDOT)/COOH-PEDOT polymeric outermost layer, is further functionalized with the antibody receptor to selectively recognize and capture the target protein. The new motor-based microchip immunoassay operations are carried out without any bulk fluid flow, replacing the common washing steps in antibody-based protein bioassays with the active transport of the captured protein throughout the different reservoirs, where each step of the immunoassay takes place. A first microchip format involving an `on-the-fly' double-antibody sandwich assay (DASA) is used for demonstrating the selective capture of the target protein, in the presence of excess of non-target proteins. A secondary antibody tagged with a polymeric-sphere tracer allows the direct visualization of the binding events. In a second approach the immuno-nanomotor captures and transports the microsphere-tagged antigen through a microchannel network. An anti-protein-A modified microengine is finally used to demonstrate the selective capture, transport and convenient label-free optical detection of a Staphylococcus aureus target bacteria (containing proteinA in its cell wall) in the presence of a large excess of non-target (Saccharomyces cerevisiae) cells. The resulting nanomotor-based microchip immunoassay offers considerable potential for diverse applications in clinical diagnostics, environmental and security monitoring fields.Here we describe the first example of using self-propelled antibody-functionalized synthetic catalytic microengines for capturing and transporting target proteins between the different reservoirs of a lab-on-a-chip (LOC) device. A new catalytic

  20. AC electric field induced dipole-based on-chip 3D cell rotation.

    Science.gov (United States)

    Benhal, Prateek; Chase, J Geoffrey; Gaynor, Paul; Oback, Björn; Wang, Wenhui

    2014-08-01

    The precise rotation of suspended cells is one of the many fundamental manipulations used in a wide range of biotechnological applications such as cell injection and enucleation in nuclear transfer (NT) cloning. Noticeably scarce among the existing rotation techniques is the three-dimensional (3D) rotation of cells on a single chip. Here we present an alternating current (ac) induced electric field-based biochip platform, which has an open-top sub-mm square chamber enclosed by four sidewall electrodes and two bottom electrodes, to achieve rotation about the two axes, thus 3D cell rotation. By applying an ac potential to the four sidewall electrodes, an in-plane (yaw) rotating electric field is generated and in-plane rotation is achieved. Similarly, by applying an ac potential to two opposite sidewall electrodes and the two bottom electrodes, an out-of-plane (pitch) rotating electric field is generated and rolling rotation is achieved. As a prompt proof-of-concept, bottom electrodes were constructed with transparent indium tin oxide (ITO) using the standard lift-off process and the sidewall electrodes were constructed using a low-cost micro-milling process and then assembled to form the chip. Through experiments, we demonstrate rotation of bovine oocytes of ~120 μm diameter about two axes, with the capability of controlling the rotation direction and the rate for each axis through control of the ac potential amplitude, frequency, and phase shift, and cell medium conductivity. The maximum observed rotation rate reached nearly 140° s⁻¹, while a consistent rotation rate reached up to 40° s⁻¹. Rotation rate spectra for zona pellucida-intact and zona pellucida-free oocytes were further compared and found to have no effective difference. This simple, transparent, cheap-to-manufacture, and open-top platform allows additional functional modules to be integrated to become a more powerful cell manipulation system.

  1. Crowd-sourced BioGames: managing the big data problem for next-generation lab-on-a-chip platforms.

    Science.gov (United States)

    Mavandadi, Sam; Dimitrov, Stoyan; Feng, Steve; Yu, Frank; Yu, Richard; Sikora, Uzair; Ozcan, Aydogan

    2012-10-21

    We describe a crowd-sourcing based solution for handling large quantities of data that are created by e.g., emerging digital imaging and sensing devices, including next generation lab-on-a-chip platforms. We show that in cases where the diagnosis is a binary decision (e.g., positive vs. negative, or infected vs. uninfected), it is possible to make accurate diagnosis by crowd-sourcing the raw data (e.g., microscopic images of specimens/cells) using entertaining digital games (i.e., ) that are played on PCs, tablets or mobile phones. We report the results and the analysis of a large-scale public experiment toward diagnosis of malaria infected human red blood cells (RBCs), where binary responses from approximately 1000 untrained individuals from more than 60 different countries are combined together (corresponding to more than 1 million cell diagnoses), resulting in an accuracy level that is comparable to those of expert medical professionals. This platform holds promise toward cost-effective and accurate tele-pathology, improved training of medical personnel, and can also be used to manage the "Big Data" problem that is emerging through next generation digital lab-on-a-chip devices.

  2. Impulse radio ultrawideband pulse shaper based on a programmable photonic chip frequency discriminator

    NARCIS (Netherlands)

    Marpaung, David; Chevalier, Ludovic; Burla, Maurizio; Roeloffzen, Chris

    2011-01-01

    We report and experimentally demonstrate the generation of impulse radio ultrawideband (UWB) pulses using a photonic chip frequency discriminator. The discriminator consists of three add-drop optical ring resonators (ORRs) which are fully programmable using thermo-optical tuning. This discriminator

  3. Generation, transmission, and detection of terahertz photons on an electrically driven single chip

    Energy Technology Data Exchange (ETDEWEB)

    Ikushima, Kenji; Ito, Atsushi; Okano, Shun [Department of Applied Physics, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo 184-8588 (Japan)

    2014-02-03

    We demonstrate single photon counting of terahertz (THz) waves transmitted from a local THz point source through a coplanar two-wire waveguide on a GaAs/AlGaAs single heterostructure crystal. In the electrically driven all-in-one chip, quantum Hall edge transport is used to achieve a noiseless injection current for a monochromatic point source of THz fields. The local THz fields are coupled to a coplanar two-wire metal waveguide and transmitted over a macroscopic scale greater than the wavelength (38 μm in GaAs). THz waves propagating on the waveguide are counted as individual photons by a quantum-dot single-electron transistor on the same chip. Photon counting on integrated high-frequency circuits will open the possibilities for on-chip quantum optical experiments.

  4. GEM400: A front-end chip based on capacitor-switch array for pixel-based GEM detector

    Science.gov (United States)

    Li, H. S.; Jiang, X. S.; Liu, G.; Wang, N.; Sheng, H. Y.; Zhuang, B. A.; Zhao, J. W.

    2012-03-01

    The upgrade of Beijing Synchrotron Radiation Facility (BSRF) needs two-dimensional position-sensitive detection equipment to improve the experimental performance. Gas Electron Multiplier (GEM) detector, in particular, pixel-based GEM detector has good application prospects in the domain of synchrotron radiation. The read-out of larger scale pixel-based GEM detector is difficult for the high density of the pixels (PAD for collecting electrons). In order to reduce the number of cables, this paper presents a read-out scheme for pixel-based GEM detector, which is based on System-in-Package technology and ASIC technology. We proposed a circuit structure based on capacitor switch array circuit, and design a chip GEM400, which is a 400 channels ASIC. The proposed circuit can achieve good stability and low power dissipation. The chip is implemented in a 0.35μm CMOS process. The basic functional circuitry in ths chip includes analog switch, analog buffer, voltage amplifier, bandgap and control logic block, and the layout of this chip takes 5mm × 5mm area. The simulation results show that the chip can allow the maximum amount of input charge 70pC on the condition of 100pF external integrator capacitor. Besides, the chip has good channel uniformity (INL is better than 0.1%) and lower power dissipation.

  5. Modification and characterization of an aptamer-based surface plasmon resonance sensor chip

    Directory of Open Access Journals (Sweden)

    Tan Junpeng

    2017-01-01

    Full Text Available Recently, aptamer-based surface plasmon resonance (SPR sensors have become increasingly popular due to their high specificity, high sensitivity, real-time detection capabilities, and label-free features. The core component of an aptamer-based SPR sensor is a chip. This paper presents the modification steps and the characterization results of a sensor chip for the construction of a 2, 4, 6-trinitrotoluene-targeted, aptamer-based, SPR sensor. After cleaning the aptamer-based SPR sensor chip, polyethylene glycol (PEG with functional thiol groups at one end was added to the chip surface by Au-S covalent bonds to form a self-assembled film. Then, the carboxyl groups at the other end of PEG and the carboxyl groups of trinitrophenyl-glycine (TNP-Gly were activated and connected via ethylenediamine (EDA. This effectively completed the chip’s modification. During the modification process, relevant experimental conditions were optimized. The chip’s surface elements, as well as their chemical states, were characterized by X-ray photoelectron spectroscopy (XPS. The results, outlined in the following study, demonstrate that this modification of an aptamer-based SPR sensor chip adhered to normative expectations. Thus, the modification process proposed here establishes an important foundation for subsequent study of TNT detection.

  6. Rational design of on-chip refractive index sensors based on lattice plasmon resonances (Presentation Recording)

    Science.gov (United States)

    Lin, Linhan; Zheng, Yuebing

    2015-08-01

    Lattice plasmon resonances (LPRs), which originate from the plasmonic-photonic coupling in gold or silver nanoparticle arrays, possess ultra-narrow linewidth by suppressing the radiative damping and provide the possibility to develop the plasmonic sensors with high figure of merit (FOM). However, the plasmonic-photonic coupling is greatly suppressed when the nanoparticles are immobilized on substrates because the diffraction orders are cut off at the nanoparticle-substrate interfaces. Here, we develop the rational design of LPR structures for the high-performance, on-chip plasmonic sensors based on both orthogonal and parallel coupling. Our finite-difference time-domain simulations in the core/shell SiO2/Au nanocylinder arrays (NCAs) reveal that new modes of localized surface plasmon resonances (LSPRs) show up when the aspect ratio of the NCAs is increased. The height-induced LSPRs couple with the superstrate diffraction orders to generate the robust LPRs in asymmetric environment. The high wavelength sensitivity and narrow linewidth in these LPRs lead to the plasmonic sensors with high FOM and high signal-to-noise ratio (SNR). Wide working wavelengths from visible to near-infrared are also achieved by tuning the parameters of the NCAs. Moreover, the wide detection range of refractive index is obtained in the parallel LPR structure. The electromagnetic field distributions in the NCAs demonstrate the height-enabled tunability of the plasmonic "hot spots" at the sub-nanoparticles resolution and the coupling between these "hot spots" with the superstrate diffraction waves, which are responsible for the high performance LPRs-based on-chip refractive index sensors.

  7. Graphene-Boron Nitride Heterostructure Based Optoelectronic Devices for On-Chip Optical Interconnects

    Science.gov (United States)

    Gao, Yuanda

    Graphene has emerged as an appealing material for a variety of optoelectronic applications due to its unique electrical and optical characteristics. In this thesis, I will present recent advances in integrating graphene and graphene-boron nitride (BN) heterostructures with confined optical architectures, e.g. planar photonic crystal (PPC) nanocavities and silicon channel waveguides, to make this otherwise weakly absorbing material optically opaque. Based on these integrations, I will further demonstrate the resulting chip-integrated optoelectronic devices for optical interconnects. After transferring a layer of graphene onto PPC nanocavities, spectral selectivity at the resonance frequency and orders-of-magnitude enhancement of optical coupling with graphene have been observed in infrared spectrum. By applying electrostatic potential to graphene, electro-optic modulation of the cavity reflection is possible with contrast in excess of 10 dB. And furthermore, a novel and complex modulator device structure based on the cavity-coupled and BN-encapsulated dual-layer graphene capacitor is demonstrated to operate at a speed of 1.2 GHz. On the other hand, an enhanced broad-spectrum light-graphene interaction coupled with silicon channel waveguides is also demonstrated with ?0.1 dB/?m transmission attenuation due to graphene absorption. A waveguide-integrated graphene photodetector is fabricated and shown 0.1 A/W photoresponsivity and 20 GHz operation speed. An improved version of a similar photodetector using graphene-BN heterostructure exhibits 0.36 A/W photoresponsivity and 42 GHz response speed. The integration of graphene and graphene-BN heterostructures with nanophotonic architectures promises a new generation of compact, energy-efficient, high-speed optoelectronic device concepts for on-chip optical communications that are not yet feasible or very difficult to realize using traditional bulk semiconductors.

  8. On-chip preparation of calcium alginate particles based on droplet templates formed by using a centrifugal microfluidic technique.

    Science.gov (United States)

    Liu, Mei; Sun, Xiao-Ting; Yang, Chun-Guang; Xu, Zhang-Run

    2016-03-15

    A novel chip-based approach for the fabrication of oblate spheriodal calcium alginate particles was developed by combining the droplet template method and the centrifugal microfluidic strategy. Circular chips with multiple radial channels were designed. Sodium alginate solutions in radial channels were flung into CaCl2 solutions in the form of droplets under centrifugal force, and the droplets transformed into particles through cross-linking reaction. The size and morphology of particles could be controlled by regulating the centrifugal force, the channel geometry and the distance between the channel outlet and the CaCl2 solution. The throughput of particle production was evidently enhanced by increasing the number of radial channels to 48 and 64. The coefficients of variation of particle sizes were in the range of 5.2-5.6%, which indicated the monodisperse particles could be prepared by using the present method. With the chip configuration readily modified, the same platform could be used to produce Janus particles. The Janus particles showed clear interfaces owing to the high flight speed and the rapid gelling process of the droplets. This method would be capable of generating particles with complicated morphology and multifunction from diverse polymeric materials.

  9. Design and Experimental Evaluation of a 3rd Generation Addressable CMOS Piezoresistive Stress Sensing Test Chip

    Energy Technology Data Exchange (ETDEWEB)

    Sweet, J.N.; Peterson, D.W.; Hsia, A.H.

    1999-04-13

    Piezoresistive stress sensing chips have been used extensively for measurement of assembly related die surface stresses. Although many experiments can be performed with resistive structures which are directly bonded, for extensive stress mapping it is necessary to have a large number of sensor cells which can be addressed using CMOS logic circuitry. Our previous test chip, the ATC04, has 100 cells, each approximately 0.012 in. on a side, on a chip with a side dimension of 0.45 in. When a cell resistor is addressed, it is connected to a four terminal measurement bus through CMOS transmission gates. In theory, the gate resistances do not affect the measurement. In practice, there may be subtle effects which appear when very high accuracy is required. At high temperatures, gate leakage can increase to a point at which the resistor measurement becomes inaccurate. For ATC04 this occurred at or above 50 C. Here, we report on the first measurements obtained with a new prototype test chip, the ATC06. This prototype was fabricated in a 0.5 micron feature size silicided CMOS process using the MOSIS prototyping facility. The cell size was approximately 0.004 in. on a side. In order to achieve piezoresistive behavior for the implanted resistors it was necessary to employ a non-standard silicide ''blocking'' process. The stress sensitivity of both implanted and polysilicon blocked resistors is discussed. Using a new design strategy for the CMOS logic, it was possible to achieve a design in which only 5 signals had to be routed to a cell for addressing vs. 9 for ATC04. With our new design, the resistor under test is more effectively electrically isolated from other resistors on the chip, thereby improving high temperature performance. We present data showing operation up to 140 C.

  10. STUDY OF CODING GENERATOR BASED ON IN-SYSTEM PROGRAMMING TECHNIQUE AND DEVICES

    Institute of Scientific and Technical Information of China (English)

    Liu Duren; Jin Yajing; Ren Zhichun

    2002-01-01

    This paper presents a design of coding waveform generator controlled by microcomputer or single-chip microcomputer and realizes arbitrary coding waveform combination based on In-system programming(ISP) technique and High Density Programmable Logic Deivce (HDPLD),and using latch register, control counter and easily expanded PS (Parallel in & Serial out) shift register array. This scheme can overcome some shortcomings in past schemes, so that hardware design can be realized by means of software.

  11. 76 FR 26283 - Blue Chip Energy LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

    Science.gov (United States)

    2011-05-06

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Blue Chip Energy LLC; Supplemental Notice That Initial Market- Based Rate...-referenced proceeding of Blue Chip Energy LLC's application for market-based rate authority, with...

  12. Lab-chip HPLC with integrated droplet-based microfluidics for separation and high frequency compartmentalisation.

    Science.gov (United States)

    Kim, Jin-Young; Cho, Soong-Won; Kang, Dong-Ku; Edel, Joshua B; Chang, Soo-Ik; deMello, Andrew J; O'Hare, Danny

    2012-09-21

    We demonstrate the integration of a droplet-based microfluidic device with high performance liquid chromatography (HPLC) in a monolithic format. Sequential operations of separation, compartmentalisation and concentration counter were conducted on a monolithic chip. This describes the use of droplet-based microfluidics for the preservation of chromatographic separations, and its potential application as a high frequency fraction collector.

  13. Real-time tunability of chip-based light source enabled by microfluidic mixing

    DEFF Research Database (Denmark)

    Olsen, Brian Bilenberg; Rasmussen, Torben; Balslev, Søren;

    2006-01-01

    We demonstrate real-time tunability of a chip-based liquid light source enabled by microfluidic mixing. The mixer and light source are fabricated in SU-8 which is suitable for integration in SU-8-based laboratory-on-a-chip microsystems. The tunability of the light source is achieved by changing...... the concentration of rhodamine 6G dye inside two integrated vertical resonators, since both the refractive index and the gain profile are influenced by the dye concentration. The effect on the refractive index and the gain profile of rhodamine 6G in ethanol is investigated and the continuous tuning of the laser...

  14. Glucose sensing by waveguide-based absorption spectroscopy on a silicon chip.

    Science.gov (United States)

    Ryckeboer, E; Bockstaele, R; Vanslembrouck, M; Baets, R

    2014-05-01

    In this work, we demonstrate in vitro detection of glucose by means of a lab-on-chip absorption spectroscopy approach. This optical method allows label-free and specific detection of glucose. We show glucose detection in aqueous glucose solutions in the clinically relevant concentration range with a silicon-based optofluidic chip. The sample interface is a spiral-shaped rib waveguide integrated on a silicon-on-insulator (SOI) photonic chip. This SOI chip is combined with micro-fluidics in poly(dimethylsiloxane) (PDMS). We apply aqueous glucose solutions with different concentrations and monitor continuously how the transmission spectrum changes due to glucose. Based on these measurements, we derived a linear regression model, to relate the measured glucose spectra with concentration with an error-of-fitting of only 1.14 mM. This paper explains the challenges involved and discusses the optimal configuration for on-chip evanescent absorption spectroscopy. In addition, the prospects for using this sensor for glucose detection in complex physiological media (e.g. serum) is briefly discussed.

  15. Immune Based Intrusion Detector Generating Algorithm

    Institute of Scientific and Technical Information of China (English)

    DONG Xiao-mei; YU Ge; XIANG Guang

    2005-01-01

    Immune-based intrusion detection approaches are studied. The methods of constructing self set and generating mature detectors are researched and improved. A binary encoding based self set construction method is applied. First,the traditional mature detector generating algorithm is improved to generate mature detectors and detect intrusions faster. Then, a novel mature detector generating algorithm is proposed based on the negative selection mechanism. Accord ing to the algorithm, less mature detectors are needed to detect the abnormal activities in the network. Therefore, the speed of generating mature detectors and intrusion detection is improved. By comparing with those based on existing algo rithms, the intrusion detection system based on the algorithm has higher speed and accuracy.

  16. Simulation-based Modeling Frameworks for Networked Multi-processor System-on-Chip

    DEFF Research Database (Denmark)

    Mahadevan, Shankar

    2006-01-01

    This thesis deals with modeling aspects of multi-processor system-on-chip (MpSoC) design affected by the on-chip interconnect, also called the Network-on-Chip (NoC), at various levels of abstraction. To begin with, we undertook a comprehensive survey of research and design practices of networked Mp......SoC. The survey presents the challenges of modeling and performance analysis of the hardware and the software components used in such devices. These challenges are further exasperated in a mixed abstraction workspace, which is typical of complex MpSoC design environment. We provide two simulation-based frameworks...... and the RIPE frameworks allows easy incorporation of IP cores from either frameworks, into a new instance of the design. This could pave the way for seamless design evaluation from system-level to cycletrue abstraction in future component-based MpSoC design practice....

  17. Titanium based flat heat pipes for computer chip cooling

    Science.gov (United States)

    Soni, Gaurav; Ding, Changsong; Sigurdson, Marin; Bozorgi, Payam; Piorek, Brian; MacDonald, Noel; Meinhart, Carl

    2008-11-01

    We are developing a highly conductive flat heat pipe (called Thermal Ground Plane or TGP) for cooling computer chips. Conventional heat pipes have circular cross sections and thus can't make good contact with chip surface. The flatness of our TGP will enable conformal contact with the chip surface and thus enhance cooling efficiency. Another limiting factor in conventional heat pipes is the capillary flow of the working fluid through a wick structure. In order to overcome this limitation we have created a highly porous wick structure on a flat titanium substrate by using micro fabrication technology. We first etch titanium to create very tall micro pillars with a diameter of 5 μm, a height of 40 μm and a pitch of 10 μm. We then grow a very fine nano structured titania (NST) hairs on all surfaces of the pillars by oxidation in H202. In this way we achieve a wick structure which utilizes multiple length scales to yield high performance wicking of water. It's capable of wicking water at an average velocity of 1 cm/s over a distance of several cm. A titanium cavity is laser-welded onto the wicking substrate and a small quantity of water is hermetically sealed inside the cavity to achieve a TGP. The thermal conductivity of our preliminary TGP was measured to be 350 W/m-K, but has the potential to be several orders of magnitude higher.

  18. Electrochemical microfluidic chip based on molecular imprinting technique applied for therapeutic drug monitoring.

    Science.gov (United States)

    Liu, Jiang; Zhang, Yu; Jiang, Min; Tian, Liping; Sun, Shiguo; Zhao, Na; Zhao, Feilang; Li, Yingchun

    2017-05-15

    In this work, a novel electrochemical detection platform was established by integrating molecularly imprinting technique with microfluidic chip and applied for trace measurement of three therapeutic drugs. The chip foundation is acrylic panel with designed grooves. In the detection cell of the chip, a Pt wire is used as the counter electrode and reference electrode, and a Au-Ag alloy microwire (NPAMW) with 3D nanoporous surface modified with electro-polymerized molecularly imprinted polymer (MIP) film as the working electrode. Detailed characterization of the chip and the working electrode was performed, and the properties were explored by cyclic voltammetry and electrochemical impedance spectroscopy. Two methods, respectively based on electrochemical catalysis and MIP/gate effect were employed for detecting warfarin sodium by using the prepared chip. The linearity of electrochemical catalysis method was in the range of 5×10(-6)-4×10(-4)M, which fails to meet clinical testing demand. By contrast, the linearity of gate effect was 2×10(-11)-4×10(-9)M with remarkably low detection limit of 8×10(-12)M (S/N=3), which is able to satisfy clinical assay. Then the system was applied for 24-h monitoring of drug concentration in plasma after administration of warfarin sodium in rabbit, and the corresponding pharmacokinetic parameters were obtained. In addition, the microfluidic chip was successfully adopted to analyze cyclophosphamide and carbamazepine, implying its good versatile ability. It is expected that this novel electrochemical microfluidic chip can act as a promising format for point-of-care testing via monitoring different analytes sensitively and conveniently.

  19. All-electronic droplet generation on-chip with real-time feedback control for EWOD digital microfluidics.

    Science.gov (United States)

    Gong, Jian; Kim, Chang-Jin C J

    2008-06-01

    Electrowetting-on-dielectric (EWOD) actuation enables digital (or droplet) microfluidics where small packets of liquids are manipulated on a two-dimensional surface. Due to its mechanical simplicity and low energy consumption, EWOD holds particular promise for portable systems. To improve volume precision of the droplets, which is desired for quantitative applications such as biochemical assays, existing practices would require near-perfect device fabrication and operation conditions unless the droplets are generated under feedback control by an extra pump setup off of the chip. In this paper, we develop an all-electronic (i.e., no ancillary pumping) real-time feedback control of on-chip droplet generation. A fast voltage modulation, capacitance sensing, and discrete-time PID feedback controller are integrated on the operating electronic board. A significant improvement is obtained in the droplet volume uniformity, compared with an open loop control as well as the previous feedback control employing an external pump. Furthermore, this new capability empowers users to prescribe the droplet volume even below the previously considered minimum, allowing, for example, 1 : x (x < 1) mixing, in comparison to the previously considered n : m mixing (i.e., n and m unit droplets).

  20. Fully integrated system-on-chip for pixel-based 3D depth and scene mapping

    Science.gov (United States)

    Popp, Martin; De Coi, Beat; Thalmann, Markus; Gancarz, Radoslav; Ferrat, Pascal; Dürmüller, Martin; Britt, Florian; Annese, Marco; Ledergerber, Markus; Catregn, Gion-Pol

    2012-03-01

    We present for the first time a fully integrated system-on-chip (SoC) for pixel-based 3D range detection suited for commercial applications. It is based on the time-of-flight (ToF) principle, i.e. measuring the phase difference of a reflected pulse train. The product epc600 is fabricated using a dedicated process flow, called Espros Photonic CMOS. This integration makes it possible to achieve a Quantum Efficiency (QE) of >80% in the full wavelength band from 520nm up to 900nm as well as very high timing precision in the sub-ns range which is needed for exact detection of the phase delay. The SoC features 8x8 pixels and includes all necessary sub-components such as ToF pixel array, voltage generation and regulation, non-volatile memory for configuration, LED driver for active illumination, digital SPI interface for easy communication, column based 12bit ADC converters, PLL and digital data processing with temporary data storage. The system can be operated at up to 100 frames per second.

  1. Chip, Chip, Hooray!

    Science.gov (United States)

    Kelly, Susan

    2001-01-01

    Presents a science laboratory using different brands of potato chips in which students test their oiliness, size, thickness, saltiness, quality, and cost, then analyze the results to determine the best chip. Gives a brief history of potato chips. (YDS)

  2. M-Sequence-Based Single-Chip UWB-Radar Sensor

    Science.gov (United States)

    Kmec, M.; Helbig, M.; Herrmann, R.; Rauschenbach, P.; Sachs, J.; Schilling, K.

    The article deals with a fully monolithically integrated single-chip M-sequence-based UWB-radar sensor, its architecture, selected design aspects and first measurement results performed on wafer and with packaged IC modules. The discussed chip is equipped with one transmitter and two receivers. The IC was designed and manufactured in commercially available high-performance 0.25 μm SiGe BiCMOS technology (f t = 110 GHz). Due to the combination of fast digital and broadband analogue system blocks in one chip, special emphasis has been placed on the electrical isolation of these functional structures. The manufactured IC is enclosed in a low-cost QFN (quad flat-pack no-leads) package and mounted on a PCB permitting the creation of MIMO-sensor arrays by cascading a number of modules. In spite of its relatively high complexity, the sensor head features a compact design (chip size of 2 × 1 mm2, QFN package size 5 × 5 mm2) and moderate power consumption (below 1 W at -3 V supply). The assembled transceiver chip can handle signals in the frequency range from near DC up to 18 GHz. This leads to an impulse response (IRF) of FWHD ≈ 50 ps (full width at half duration).

  3. Simultaneous detection of lactate and glucose by integrated printed circuit board based array sensing chip.

    Science.gov (United States)

    Li, Xuelian; Zang, Jianfeng; Liu, Yingshuai; Lu, Zhisong; Li, Qing; Li, Chang Ming

    2013-04-10

    An integrated printed circuit board (PCB) based array sensing chip was developed to simultaneously detect lactate and glucose in mouse serum. The novelty of the chip relies on a concept demonstration of inexpensive high-throughput electronic biochip, a chip design for high signal to noise ratio and high sensitivity by construction of positively charged chitosan/redox polymer Polyvinylimidazole-Os (PVI-Os)/carbon nanotube (CNT) composite sensing platform, in which the positively charged chitosan/PVI-Os is mediator and electrostatically immobilizes the negatively charged enzyme, while CNTs function as an essential cross-linker to network PVI-Os and chitosan due to its negative charged nature. Additional electrodes on the chip with the same sensing layer but without enzymes were prepared to correct the interferences for high specificity. Low detection limits of 0.6 μM and 5 μM were achieved for lactate and glucose, respectively. This work could be extended to inexpensive array sensing chips with high sensitivity, good specificity and high reproducibility for various sensor applications.

  4. SU-8 as a material for lab-on-a-chip-based mass spectrometry.

    Science.gov (United States)

    Arscott, Steve

    2014-10-07

    This short review focuses on the application of SU-8 for the microchip-based approach to the miniaturization of mass spectrometry. Chip-based mass spectrometry will make the technology commonplace and bring benefits such as lower costs and autonomy. The chip-based miniaturization of mass spectrometry necessitates the use of new materials which are compatible with top-down fabrication involving both planar and non-planar processes. In this context, SU-8 is a very versatile epoxy-based, negative tone resist which is sensitive to ultraviolet radiation, X-rays and electron beam exposure. It has a very wide thickness range, from nanometres to millimetres, enabling the formation of mechanically rigid, very high aspect ratio, vertical, narrow width structures required to form microfluidic slots and channels for laboratory-on-a-chip design. It is also relatively chemically resistant and biologically compatible in terms of the liquid solutions used for mass spectrometry. This review looks at the impact and potential of SU-8 on the different parts of chip-based mass spectrometry - pre-treatment, ionization processes, and ion sorting and detection.

  5. Bell states generation on a III-V semiconductor chip at room temperature

    CERN Document Server

    Orieux, Adeline; Lemaître, Aristide; Filloux, Pascal; Favero, Ivan; Leo, Giuseppe; Coudreau, Thomas; Keller, Arne; Milman, Pérola; Ducci, Sara

    2013-01-01

    We demonstrate the generation of polarization-entangled photon pairs at room temperature and telecom wavelength in a AlGaAs semiconductor waveguide. The source is based on spontaneous parametric down conversion with a counterpropagating phase-matching scheme. The quality of the two-photon state is assessed by the reconstruction of the density matrix giving a raw fidelity to a Bell state of 0.83; a theoretical model, taking into account the experimental parameters, provides ways to understand and control the amount of entanglement. Its compatibility with electrical injection, together with the high versatility of the generated two-photon state, make this source an attractive candidate for completely integrated quantum photonics devices.

  6. Integrated optical displacement sensor based on asymmetric Mach-Zehnder interferometer chip

    Science.gov (United States)

    Zhao, Ning; Qian, Guang; Fu, Xing-Chang; Zhang, Li-Jiang; Hu, Wei; Li, Ruo-Zhou; Zhang, Tong

    2017-02-01

    Displacement sensor is one of the most important measuring instruments in many automated systems. We demonstrated an integrated optical displacement sensor based on an asymmetric Mach-Zehnder interferometer chip on a flexible substrate. The sensing chip was made of polymer materials and fabricated by lithography and lift-off techniques. Measured results show that the device has a loss of less than 5 dB and a potential sensitivity of about 0.105 rad/μm with quite a large space for promotion. The sensor has advantages of antielectromagnetic interference, high reliability and stability, simple preparing process, and low cost; it will occupy an important place in displacement sensors.

  7. Integrated Surface-enhanced Raman Spectroscopy chip based on liquid core waveguide

    CERN Document Server

    Lai, Chunhong; Chen, Li; Li, Junhui; Liu, Qinghao; Xu, Yi

    2015-01-01

    We propose an integrated surface enhanced Raman scattering (SERS) chip based on liquid-core waveguide with total reflection, through which the depression of leaky mode enable a long propagating distance. An Raman enhancement factor for rhodamine 6G of 2.5*105 is obtained, and a excellent repeatability is shown. The peaks in the SERS spectrum of DNA of silkworm clearly illustrate the information of the molecule structure. The integration of the SERS substrate, micro-fluid, and liquid-core waveguide make such a SERS chip attractive for biochemical detection with high performance.

  8. A novel method to prepare SPR sensor chips based on photografting molecularly imprinted polymer

    Institute of Scientific and Technical Information of China (English)

    Qing Quan Wei; Tian Xin Wei

    2011-01-01

    A novel method to prepare surface plasmon resonance (SPR) sensor chips based on grafted imprinted polymer is explored. Benzophenone photografting system is used to grow molecularly imprinted polymer (MIP) films from the modified surface of gold substrate. The surface morphology and thickness of MIP films were investigated by scanning electronic microscope (SEM). The adsorption properties of sensor chip were studied by SPR spectroscopy. The results demonstrate that nano-MIP films can be constructed on the surface of gold substrate with the good adsorption of template molecules.

  9. On-Chip Power-Combining for High-Power Schottky Diode-Based Frequency Multipliers

    Science.gov (United States)

    Chattopadhyay, Goutam; Mehdi, Imran; Schlecht, Erich T.; Lee, Choonsup; Siles, Jose V.; Maestrini, Alain E.; Thomas, Bertrand; Jung, Cecile D.

    2013-01-01

    A 1.6-THz power-combined Schottky frequency tripler was designed to handle approximately 30 mW input power. The design of Schottky-based triplers at this frequency range is mainly constrained by the shrinkage of the waveguide dimensions with frequency and the minimum diode mesa sizes, which limits the maximum number of diodes that can be placed on the chip to no more than two. Hence, multiple-chip power-combined schemes become necessary to increase the power-handling capabilities of high-frequency multipliers. The design presented here overcomes difficulties by performing the power-combining directly on-chip. Four E-probes are located at a single input waveguide in order to equally pump four multiplying structures (featuring two diodes each). The produced output power is then recombined at the output using the same concept.

  10. A PDMS-Based Microfluidic Hanging Drop Chip for Embryoid Body Formation

    Directory of Open Access Journals (Sweden)

    Huei-Wen Wu

    2016-07-01

    Full Text Available The conventional hanging drop technique is the most widely used method for embryoid body (EB formation. However, this method is labor intensive and limited by the difficulty in exchanging the medium. Here, we report a microfluidic chip-based approach for high-throughput formation of EBs. The device consists of microfluidic channels with 6 × 12 opening wells in PDMS supported by a glass substrate. The PDMS channels were fabricated by replicating polydimethyl-siloxane (PDMS from SU-8 mold. The droplet formation in the chip was tested with different hydrostatic pressures to obtain optimal operation pressures for the wells with 1000 μm diameter openings. The droplets formed at the opening wells were used to culture mouse embryonic stem cells which could subsequently developed into EBs in the hanging droplets. This device also allows for medium exchange of the hanging droplets making it possible to perform immunochemistry staining and characterize EBs on chip.

  11. Trip Generation Model Based on Destination Attractiveness

    Institute of Scientific and Technical Information of China (English)

    YAO Liya; GUAN Hongzhi; YAN Hai

    2008-01-01

    Traditional trip generation forecasting methods use unified average trip generation rates to determine trip generation volumes in various traffic zones without considering the individual characteristics of each traffic zone.Therefore,the results can have significant errors.To reduce the forecasting error produced by uniform trip generation rates for different traffic zones,the behavior of each traveler was studied instead of the characteristics of the traffic zone.This paper gives a method for calculating the trip efficiency and the effect of traffic zones combined with a destination selection model based on disaggregate theory for trip generation.Beijing data is used with the trip generation method to predict trip volumes.The results show that the disaggregate model in this paper is more accurate than the traditional method.An analysis of the factors influencing traveler behavior and destination selection shows that the attractiveness of the traffic zone strongly affects the trip generation volume.

  12. Experiment-Based Computational Investigation of Thermomechanical Stresses in Flip Chip BGA Using the ATC4.2 Test Vehicle

    Energy Technology Data Exchange (ETDEWEB)

    Burchett, Steven N.; Nguyen, Luu; Peterson, David W.; Sweet, James N.

    1999-08-02

    Stress measurement test chips were flip chip assembled to organic BGA substrates containing micro-vias and epoxy build-up interconnect layers. Mechanical degradation observed during temperature cycling was correlated to a damage theory developed based on 3D finite element method analysis. Degradation included die cracking, edge delamination and radial fillet cracking.

  13. A PRIORITY-BASED POLLING SCHEDULING ALGORITHM FOR ARBITRATION POLICY IN NETWORK ON CHIP

    Institute of Scientific and Technical Information of China (English)

    Bao Liyong; Zhao Dongfeng; Zhao Yifan

    2012-01-01

    A solution is imperatively expected to meet the efficient contention resolution schemes for managing simultaneous access requests to the communication resources on the Network on Chip (NoC).Based on the ideas of conflict-free transmission,priority-based service,and dynamic self-adaptation to loading,this paper presents a novel scheduling algorithm for Medium Access Control (MAC) in NoC with the researches of the communication structure features of 2D mesh.The algorithm gives priority to guarantee the Quality of Service (QoS) for local input port as well as dynamic adjustment of the performance of the other ports along with input load change.The theoretical model of this algorithm is established with Markov chain and probability generating function.Mathematical analysis is made on the mean queue length and the mean inquiry cyclic time of the system.Simulated experiments are conducted to test the accuracy of the model.It turns out that the findings from theoretical analysis correspond well with those from simulated experiments.Further more,the analytical findings of the system performance demonstrate that the algorithm enables effectively strengthen the fairness and stability of data transmissions in NoC.

  14. Topas Based Lab-on-a-chip Microsystems Fabricated by Thermal Nanoimprint Lithography

    DEFF Research Database (Denmark)

    Olsen, Brian Bilenberg; Hansen, Michael Søren; Özkapici, V.

    2005-01-01

    We, present a one-step technology for fabrication of Topas-based lab-on-a-chip (LOC) microsysterris by the use of thermal nanoimprint lithography (NIL). The technology is demonstrated by the fabrication of two working devices: a particle separator and a LOC with integrated optics for absorbance...

  15. On-chip Mode Multiplexer Based on a Single Grating Coupler

    DEFF Research Database (Denmark)

    Ding, Yunhong; Ou, Haiyan; Xu, Jing;

    2012-01-01

    A two-mode multiplexer based on a single grating coupler is proposed and demonstrated on a silicon chip. The LP01 and LP11 modes of a few-mode fiber are excited from TE0 and TE1 silicon waveguide modes....

  16. MEMS-Based Quartz Oscillators and Filters for On-Chip Integration

    Science.gov (United States)

    2005-01-01

    frequency RF electronics, and vacuum packaging the resulting chip at wafer level, are not possible with present techniques. Polysilicon surface...and is compatible with MEMS-based wafer-scale vacuum packaging . Fundamental mode operation above 2 GHz has been demonstrated with Q’s of 7,200 in air

  17. PDMS based microfluidic chips and their application in material synthesis

    Science.gov (United States)

    Gong, Xiuqing

    Microfluidics is a highly interdisciplinary science which is to deal with the behavior, control and manipulation of fluids that are constrained to sub-milimeter scale. It incorporates the knowledge and technique intersecting physics, chemistry, mechanics, nanoscience and biotechnology, with practical applications to the design of systems in which small volumes of fluids will be used. In this thesis, we started our research from GER fluid synthesis which then is applied to designing different functions of microfluidic devices, valve, pump, and mixer. We built a way to correlate mechanical signal with electric signal by soft matter. The mechanical devices based GER fluid had good operating stability and mechanical performance. We studied how to improve the performance of GER fluid by increasing the yield stress while avoiding the sendimentation of nanoparticles in GER suspension. The meaning of this work is to enhance the stability and mechanical strength of GER fluid when it is applyed to the microfluidc channels. We tried different oils and studied the particle size for the GER effect. The largest yield stress which amounts to 300 kPa is achievable compared to previous GER fluid with 100 kPa. Microfluidic reactor, directing the flow of microliter volumes along microscale channels, offers the advantages of precise control of reagent loading, fast mixing and an enhanced reaction rate, cessation of the reaction at specific stages, and more. Basically, there are two microfluidic flow regimes, continuous flow and segmented flow (suspended droplets, channel-spanning slug, and wall-wetting films). Both flow regimes offer chemical reaction applications, e.g., continuous flow formation of polymer nanospheres and inorganic nanoparticles, size- and shape-control synthesis by segmented flow, and precipitate-forming reactions in droplets, wherein the segmented flow has gained more popularity in that area. The compartmentalization of segmented flow offers advantages to chemical

  18. On-chip generation and guiding of quantum light from a site-controlled quantum dot

    Energy Technology Data Exchange (ETDEWEB)

    Jamil, Ayesha; Farrer, Ian; Griffiths, Jonathan P.; Jones, Geb A. C.; Ritchie, David A. [Cavendish Laboratory, University of Cambridge, J. J. Thomson Avenue, Cambridge CB3 0HE (United Kingdom); Skiba-Szymanska, Joanna; Kalliakos, Sokratis; Ward, Martin B.; Ellis, David J. P.; Shields, Andrew J., E-mail: andrew.shields@crl.toshiba.co.uk [Cambridge Research Laboratory, Toshiba Research Europe Limited, 208 Science Park, Milton Road, Cambridge, CB4 0GZ (United Kingdom); Schwagmann, Andre; Brody, Yarden [Cavendish Laboratory, University of Cambridge, J. J. Thomson Avenue, Cambridge CB3 0HE (United Kingdom); Cambridge Research Laboratory, Toshiba Research Europe Limited, 208 Science Park, Milton Road, Cambridge, CB4 0GZ (United Kingdom)

    2014-03-10

    We demonstrate the emission and routing of single photons along a semiconductor chip originating from carrier recombination in an actively positioned InAs quantum dot. Device–scale arrays of quantum dots are formed by a two–step regrowth process. We precisely locate the propagating region of a unidirectional photonic crystal waveguide with respect to the quantum dot nucleation site. Under pulsed optical excitation, the multiphoton emission probability from the waveguide's exit is 12% ± 5% before any background correction. Our results are a major step towards the deterministic integration of a quantum emitter with the waveguiding components of photonic quantum circuits.

  19. A compound magnetic field generating system for targeted killing of Staphylococcus aureus by magnetotactic bacteria in a microfluidic chip

    Science.gov (United States)

    Chen, Linjie; Chen, Changyou; Wang, Pingping; Chen, Chuanfang; Wu, Long-Fei; Song, Tao

    2017-04-01

    A compound magnetic field generating system was built to kill Staphylococcus aureus (S. aureus) by magnetotactic bacteria (MTB) in a microfluidic chip in this paper. The system was consisted of coil pairs, a switch circuit, a control program and controllable electrical sources. It could produce a guiding magnetic field (gMF) of ±1 mT along arbitrary direction in the horizontal plane, a rotating magnetic field (rMF) and a swing magnetic field (sMF, 2 Hz, 10 mT) by controlling the currents. The gMF was used to guide MTB swimming to the S. aureus pool in the microfluidic chip, and then the rMF enhanced the mixture of S. aureus and MTB cells, therefore beneficial to the attachments of them. Finally, the sMF was used to induce the death of S. aureus via MTB. The results showed that MTB could be navigated by the gMF and that 47.1% of S. aureus were killed when exposed to the sMF. It provides a new solution for the targeted treatment of infected diseases and even cancers.

  20. Secure chip based encrypted search protocol in mobile office environments

    Directory of Open Access Journals (Sweden)

    Hyun-A Park

    2016-05-01

    Full Text Available This paper deals with largely two security problems between the cloud computing service and trusted platform module (TPM chip as a mobile convergent technology. At first, we solve the social issues from inside attackers, which is caused by that we regard server managers as trustworthy. In order to solve this problem, we propose encrypted DB retrieval system whose server manager cannot access on real data (plaintexts in mobile office environments of the cloud datacenter. The other problem is that cloud computing has limitless computing resources; however, it faces with the vulnerability of security. On the other hand, the TPM technology has been known as a symbol of physical security; however, it has the severe limitation of use such as hardware constraints or limited amount of non-volatile memory. To overcome the weakness and produce synergic effects between the two technologies, we combine two applications (cloud datacenter service, TPM chip as a mobile convergent technology. The main methods are TPM-security-client and masked keys. With these methods, the real keys are stored in TPM and the faked keys (masked keys are implemented for computations instead of real keys. Thus, the result of the faked keys is the same as the real keys. Consequently, this system is secure against both of the insiders and outsiders, the cloud computing service can improve security weaknesses.

  1. Testing of PLL-based True Random Number Generator in Changing Working Conditions

    Directory of Open Access Journals (Sweden)

    M. Simka

    2011-04-01

    Full Text Available Security of cryptographic systems depends significantly on security of secret keys. Unpredictability of the keys is achieved by their generation by True Random Number Generators (TRNGs. In the paper we analyze behavior of the Phase-Locked Loop (PLL based TRNG in changing working environment. The frequency of signals synthesized by PLL may be naturally influenced by chip temperature. We show what impact the temperature has on the quality of generated random sequence of the PLL-based TRNG. Thank to analysis of internal signals of the generator we are able to prove dependencies between the PLL parameters, statistical parameters of the generated sequence and temperature. Considering the measured results of experiments we form a new requirement in order to improve the robustness of the designed TRNG.

  2. High performance magnesium anode in paper-based microfluidic battery, powering on-chip fluorescence assay.

    Science.gov (United States)

    Koo, Youngmi; Sankar, Jagannathan; Yun, Yeoheung

    2014-09-01

    A high power density and long-lasting stable/disposable magnesium battery anode was explored for a paper-based fluidic battery to power on-chip functions of various Point of Care (POC) devices. The single galvanic cell with magnesium foil anode and silver foil cathode in Origami cellulose chip provided open circuit potential, 2.2 V, and power density, 3.0 mW/cm(2). A paper-based fluidic galvanic cell was operated with one drop of water (80 μl) and continued to run until it was dry. To prove the concept about powering on-chip POC devices, two-serial galvanic cells are developed and incorporated with a UV-light emitting diode (λ = 365 nm) and fluorescence assay for alkaline phosphatase reaction. Further, detection using smart phones was performed for quantitative measurement of fluorescent density. To conclude, a magnesium-based fluidic battery paper chip was extremely low-cost, required minute sample volumes, was easy to dispose of, light weight, easy to stack, store and transport, easy to fabricate, scalable, and has faster analysis times.

  3. Advanced Micro Narrows Gap in Race for New Chip

    Institute of Scientific and Technical Information of China (English)

    John Markoff; 张宁

    2004-01-01

    @@ Hoping to catch up with Intel and I. B. M. in an advanced chip-making technology, the semiconductor maker Advanced Micro Devices plans to announce Tuesday that it has begun to ship chips based on an advanced manufacturing process that is being used to build the next generation of processors.

  4. An SOI CMOS-Based Multi-Sensor MEMS Chip for Fluidic Applications.

    Science.gov (United States)

    Mansoor, Mohtashim; Haneef, Ibraheem; Akhtar, Suhail; Rafiq, Muhammad Aftab; De Luca, Andrea; Ali, Syed Zeeshan; Udrea, Florin

    2016-11-04

    An SOI CMOS multi-sensor MEMS chip, which can simultaneously measure temperature, pressure and flow rate, has been reported. The multi-sensor chip has been designed keeping in view the requirements of researchers interested in experimental fluid dynamics. The chip contains ten thermodiodes (temperature sensors), a piezoresistive-type pressure sensor and nine hot film-based flow rate sensors fabricated within the oxide layer of the SOI wafers. The silicon dioxide layers with embedded sensors are relieved from the substrate as membranes with the help of a single DRIE step after chip fabrication from a commercial CMOS foundry. Very dense sensor packing per unit area of the chip has been enabled by using technologies/processes like SOI, CMOS and DRIE. Independent apparatuses were used for the characterization of each sensor. With a drive current of 10 µA-0.1 µA, the thermodiodes exhibited sensitivities of 1.41 mV/°C-1.79 mV/°C in the range 20-300 °C. The sensitivity of the pressure sensor was 0.0686 mV/(Vexcit kPa) with a non-linearity of 0.25% between 0 and 69 kPa above ambient pressure. Packaged in a micro-channel, the flow rate sensor has a linearized sensitivity of 17.3 mV/(L/min)(-0.1) in the tested range of 0-4.7 L/min. The multi-sensor chip can be used for simultaneous measurement of fluid pressure, temperature and flow rate in fluidic experiments and aerospace/automotive/biomedical/process industries.

  5. Chip-based Three-dimensional Cell Culture in Perfused Micro-bioreactors

    Science.gov (United States)

    Gottwald, Eric; Lahni, Brigitte; Thiele, David; Giselbrecht, Stefan; Welle, Alexander; Weibezahn, Karl-Friedrich

    2008-01-01

    We have developed a chip-based cell culture system for the three-dimensional cultivation of cells. The chip is typically manufactured from non-biodegradable polymers, e.g., polycarbonate or polymethyl methacrylate by micro injection molding, micro hot embossing or micro thermoforming. But, it can also be manufactured from bio-degradable polymers. Its overall dimensions are 0.7 1 x 20 x 20 x 0.7 1 mm (h x w x l). The main features of the chips used are either a grid of up to 1156 cubic micro-containers (cf-chip) each the size of 120-300 x 300 x 300 μ (h x w x l) or round recesses with diameters of 300 μ and a depth of 300 μ (r-chip). The scaffold can house 10 Mio. cells in a three-dimensional configuration. For an optimal nutrient and gas supply, the chip is inserted in a bioreactor housing. The bioreactor is part of a closed steril circulation loop that, in the simplest configuration, is additionaly comprised of a roller pump and a medium reservoir with a gas supply. The bioreactor can be run in perfusion, superfusion, or even a mixed operation mode. We have successfully cultivated cell lines as well as primary cells over periods of several weeks. For rat primary liver cells we could show a preservation of organotypic functions for more than 2 weeks. For hepatocellular carcinoma cell lines we could show the induction of liver specific genes not or only slightly expressed in standard monolayer culture. The system might also be useful as a stem cell cultivation system since first differentiation experiments with stem cell lines were promising. PMID:19066592

  6. An SOI CMOS-Based Multi-Sensor MEMS Chip for Fluidic Applications

    Directory of Open Access Journals (Sweden)

    Mohtashim Mansoor

    2016-11-01

    Full Text Available An SOI CMOS multi-sensor MEMS chip, which can simultaneously measure temperature, pressure and flow rate, has been reported. The multi-sensor chip has been designed keeping in view the requirements of researchers interested in experimental fluid dynamics. The chip contains ten thermodiodes (temperature sensors, a piezoresistive-type pressure sensor and nine hot film-based flow rate sensors fabricated within the oxide layer of the SOI wafers. The silicon dioxide layers with embedded sensors are relieved from the substrate as membranes with the help of a single DRIE step after chip fabrication from a commercial CMOS foundry. Very dense sensor packing per unit area of the chip has been enabled by using technologies/processes like SOI, CMOS and DRIE. Independent apparatuses were used for the characterization of each sensor. With a drive current of 10 µA–0.1 µA, the thermodiodes exhibited sensitivities of 1.41 mV/°C–1.79 mV/°C in the range 20–300 °C. The sensitivity of the pressure sensor was 0.0686 mV/(Vexcit kPa with a non-linearity of 0.25% between 0 and 69 kPa above ambient pressure. Packaged in a micro-channel, the flow rate sensor has a linearized sensitivity of 17.3 mV/(L/min−0.1 in the tested range of 0–4.7 L/min. The multi-sensor chip can be used for simultaneous measurement of fluid pressure, temperature and flow rate in fluidic experiments and aerospace/automotive/biomedical/process industries.

  7. Graph based techniques for tag cloud generation

    DEFF Research Database (Denmark)

    Leginus, Martin; Dolog, Peter; Lage, Ricardo Gomes

    2013-01-01

    Tag cloud is one of the navigation aids for exploring documents. Tag cloud also link documents through the user defined terms. We explore various graph based techniques to improve the tag cloud generation. Moreover, we introduce relevance measures based on underlying data such as ratings or citat......Tag cloud is one of the navigation aids for exploring documents. Tag cloud also link documents through the user defined terms. We explore various graph based techniques to improve the tag cloud generation. Moreover, we introduce relevance measures based on underlying data such as ratings...

  8. Contingency Base Camp Solid Waste Generation

    Science.gov (United States)

    2013-09-01

    wastes gener- ated at Army base camps. The data in this report were obtained from solid waste characterization surveys of base camps in Bosnia, Kosovo ...ER D C/ CE RL T R- 13 -1 7 Contingency Base Camp Solid Waste Generation Co ns tr uc tio n En gi ne er in g R es ea rc h La bo ra to...Contingency Base Camp Solid Waste Generation Stephen D. Cosper, H. Garth Anderson, Kurt Kinnevan, and Byung J. Kim Construction Engineering Research

  9. Silicon-chip-based mid-infrared dual-comb spectroscopy

    CERN Document Server

    Yu, Mengjie; Griffith, Austin G; Picqué, Nathalie; Lipson, Michal; Gaeta, Alexander L

    2016-01-01

    On-chip spectroscopy that could realize real-time fingerprinting with label-free and high-throughput detection of trace molecules is one of the 'holy grails" of sensing. Such miniaturized spectrometers would greatly enable applications in chemistry, bio-medicine, material science or space instrumentation, such as hyperspectral microscopy of live cells or pharmaceutical quality control. Dual-comb spectroscopy (DCS), a recent technique of Fourier transform spectroscopy without moving parts, is particularly promising since it measures high-precision spectra in the gas phase using only a single detector. Here, we present a microresonator-based platform designed for mid-infrared (mid-IR) DCS. A single continuous-wave (CW) low-power pump source generates two mutually coherent mode-locked frequency combs spanning from 2.6 $\\mu$m to 4.1 $\\mu$m in two silicon micro-resonators. Thermal control and free-carrier injection control modelocking of each comb and tune the dual-comb parameters. The large line spacing of the co...

  10. Droplet-based Biosensing for Lab-on-a-Chip, Open Microfluidics Platforms

    Directory of Open Access Journals (Sweden)

    Piyush Dak

    2016-04-01

    Full Text Available Low cost, portable sensors can transform health care by bringing easily available diagnostic devices to low and middle income population, particularly in developing countries. Sample preparation, analyte handling and labeling are primary cost concerns for traditional lab-based diagnostic systems. Lab-on-a-chip (LoC platforms based on droplet-based microfluidics promise to integrate and automate these complex and expensive laboratory procedures onto a single chip; the cost will be further reduced if label-free biosensors could be integrated onto the LoC platforms. Here, we review some recent developments of label-free, droplet-based biosensors, compatible with “open” digital microfluidic systems. These low-cost droplet-based biosensors overcome some of the fundamental limitations of the classical sensors, enabling timely diagnosis. We identify the key challenges that must be addressed to make these sensors commercially viable and summarize a number of promising research directions.

  11. Droplet-based Biosensing for Lab-on-a-Chip, Open Microfluidics Platforms.

    Science.gov (United States)

    Dak, Piyush; Ebrahimi, Aida; Swaminathan, Vikhram; Duarte-Guevara, Carlos; Bashir, Rashid; Alam, Muhammad A

    2016-04-14

    Low cost, portable sensors can transform health care by bringing easily available diagnostic devices to low and middle income population, particularly in developing countries. Sample preparation, analyte handling and labeling are primary cost concerns for traditional lab-based diagnostic systems. Lab-on-a-chip (LoC) platforms based on droplet-based microfluidics promise to integrate and automate these complex and expensive laboratory procedures onto a single chip; the cost will be further reduced if label-free biosensors could be integrated onto the LoC platforms. Here, we review some recent developments of label-free, droplet-based biosensors, compatible with "open" digital microfluidic systems. These low-cost droplet-based biosensors overcome some of the fundamental limitations of the classical sensors, enabling timely diagnosis. We identify the key challenges that must be addressed to make these sensors commercially viable and summarize a number of promising research directions.

  12. Phase matched second harmonic generation in an on-chip lithium niobate microresonator fabricated by femtosecond laser

    CERN Document Server

    Lin, Jintian; Ni, Jielei; Wang, Min; Fang, Zhiwei; Qiao, Lingling; Fang, Wei; Cheng, Ya

    2015-01-01

    Nonlinear optical processes in whispering gallery mode (WGM) microresonators have attracted much attention. Owing to the strong confinement of light in a small volume, a WGM microresonator can dramatically boost the strength of light field, thereby promoting the nonlinear interaction between the light and the resonator material. However, realization of efficient nonlinear parametric process in microresonators is a challenging issue. The major difficulty is to simultaneously ensure the phase matching condition and a coherent multiple resonance condition for all the waves participating in the nonlinear conversion process. Here, we demonstrate highly efficient second harmonic generation (SHG) in an on-chip lithium niobate microresonator fabricated by femtosecond laser direct writing. We overcome the difficulty of double resonance for the phase matched pump and second harmonic waves by selectively exciting high order modes in the fabricated thin-disk microresonator. Our technique opens opportunities for integrate...

  13. Continuous Jetting of Alginate Microfiber in Atmosphere Based on a Microfluidic Chip

    Directory of Open Access Journals (Sweden)

    Junyi Zhao

    2017-01-01

    Full Text Available We present a method based on a microfluidic chip that produces continuous jetting of alginate microfiber in the atmosphere to facilitate its collection and assembly. Through the analysis of the factors influencing the microfiber jetting, the principle and some microfluidic chip design criteria are discussed. A special nozzle is designed near the chip outlet, and deionized water is introduced into the microchannel through the nozzle to increase the flux and thus to prevent drop formation around the outlet which impedes the continuous jetting of microfiber. The experiments have reported the effectiveness of the proposed structure and shown that the introduction of sheath flow promotes the stability of the flow field in the microchannel and does not affect the morphology of microfiber. Simulations of velocity and pressure distribution in the microchannel are also conducted. Further, the jetting microfibers are collected and assembled into various 3D complex fiber-based macroscopic structures through patterning or reeling. Since the proposed structure is rather simple and can be easily integrated into other complex structures without adding more soft-lithographical steps, microfibers with various morphology and function can be synthesized and collected in a single chip, which can be applied to various fields, such as tissue engineering, biotechnology, and drug discovery.

  14. Design and Fabrication of a Monolithic Optoelectronic Integrated Circuit Chip Based on CMOS Compatible Technology

    Institute of Scientific and Technical Information of China (English)

    GUO Wei-Feng; ZHAO Yong; WANG Wan-Jun; SHAO Hai-Feng; YANG Jian-Yi; JIANG Xiao-Qing

    2012-01-01

    A monolithic optoelectronic integrated circuit chip on a silicon-on-insulator is designed and fabricated based on complementary metal oxide semiconductor compatible technology.The chip integrates an optical Mach-Zehnder modulator (MZM) and a CMOS driving circuit with the amplification function.Test results show that the extinction ratio of the MZM is close to 20dB and the small-signal gain of the CMOS driving circuit is about 26.9dB.A 50m V 10 MHz sine wave signal is amplified by the driving circuit,and then drives the MZM successfully.%A monolithic optoelectronic integrated circuit chip on a silicon-on-insulator is designed and fabricated based on complementary metal oxide semiconductor compatible technology. The chip integrates an optical Mach-Zehnder modulator (MZM) and a CMOS driving circuit with the amplification function. Test results show that the extinction ratio of the MZM is close to 20 dB and the small-signal gain of the CMOS driving circuit is about 26.9dB. A 50mV 10MHz sine wave signal is amplified by the driving circuit, and then drives the MZM successfully.

  15. Development of an AOI system for chips with a hole on backside based on a frame imager

    Science.gov (United States)

    Chen, Ming-Fu; Chou, Chih-Chung; Lien, Chun-Chien; Weng, Rui-Cian

    2016-01-01

    Defects exist for a few of IC chips during fabrication and packaging. The cost for follow-up processes can be reduced if chips with defect size of impacting chip quality can be inspected and removed during the earlier sorting process. Products will be more cost-effective and competitive. According to the inspecting requirements for microphone chips, developed AOI system has to detect the boundary flaws and hole-inside defects with size of greater than criteria from chips backside. Both the length and width of chip size are less than 5 mm and there's depth difference between the surface of chip backside and the hole-inside membrance. Thus image acquisition device is designed and implemented by an area scan imager and a telecentric lenses with a coaxial LED lighting module. Therefore we can ignore the image radiometric and geometric calibration, and keep off the shadow inside the rim of hole. An algorithm to detect defects and derive their size based on the edge pixels statistic distribution and binary chip edge image is selected. Developed AOI system then can meet the requirements of real-time defect inspection with high accuracy and performance. Frame opto-mechanical device has the spatial resolution of 5μm and FOV of 6.4 x 5.1 mm. And defect inspection can be completed within 150 ms for the chip size of 2.5 x 3.0 mm. The processes of image acquisition and defect inspection can be accomplished during the chip sorting process to satisfy the real-time online inspection. Inspected chips are placed in GO/NG trays in real-time according to their quality. From the verification results compared with the ones by microscope, the inspection accuracy is better than system requirements. The over kill rate is less than 0.3% and 3% for chip boundary flaws and hole-inside defects respectively. But it still can't be inspected correctly for the hole-inside defects of only one membrance breakage. In the future, we will improve the illumination and detecting algorithm to solve this

  16. Microfluidic chip-based analytical system for rapid screening of photocatalysts.

    Science.gov (United States)

    Zhang, Hao; Wang, Jing-Jing; Fan, Jie; Fang, Qun

    2013-11-15

    A simple and efficient microfluidic chip-based analytical system for rapid screening of photocatalysts was developed. The catalyst screening system consisted of a microchip with multiple channels for parallel reactions, a UV light source, and a CCD camera-based photometric detection system for monitoring the photocatalytic reaction. A novel microfluidic introduction method for loading particle samples into chip microchannels was established using dry sample powders and wedge-structure channel design. With this method, multiple different photocatalyst samples could be quickly introduced into the microchip with good reproducibility without the need of additional pumps or valves. We applied the present system in the rapid screening of doping TiO2 photocatalysts in terms of their activity for methylene blue (MB) degradation under UV light irradiation. Ten parallel photocatalyst screening reactions were achieved within 15 min in the multi-channel chip. We also examined nine element doped TiO2 materials to investigate the doping effects of different elements on TiO2. Compared with conventional systems, the photocatalyst consumption (0.1mg) in the present system was significantly reduced at least 100 times. High reaction rate in chip microreactors was obtained with an increase of two orders of magnitude over bulk reactors. The miniaturization of the photocatalytic reaction on the microchip significantly improves the reaction rates, reduces the sample and reagent consumptions, and increases the throughput of screening for multiple catalyst samples in parallel. The present work provides a novel application for microfluidic chip-based analytical systems, as well as a rapid, highly-efficient and low-consumption method for screening of photocatalysts.

  17. Radio lighting based on dynamic chaos generators

    CERN Document Server

    Dmitriev, Alexander; Gerasimov, Mark; Itskov, Vadim

    2016-01-01

    A problem of lighting objects and surfaces with artificial sources of noncoherent microwave radiation with the aim to observe them using radiometric equipment is considered. Transmitters based on dynamic chaos generators are used as sources of noncoherent wideband microwave radiation. An experimental sample of such a device, i.e., a radio lighting lamp based on a chaos microgenerator and its performance are presented.

  18. Application Aware Topology Generation for Surface Wave Networks-on-Chip

    Institute of Scientific and Technical Information of China (English)

    Zhao Fu; Zheng-Bing Hu; Cheng Gong; Wen-Ming Pan; Guo-Bin Lv

    2014-01-01

    The networks-on-chip (NoC) communica-tion has an increasingly larger impact on the system power consumption and performance. Emerging technologies, like surface wave, are believed to have lower transmission latency and power consumption over the conventional wireless NoC. Therefore, this paper studies how to optimize the network performance and power consumption by giving the packet-switching fabric and traffic pattern of each application. Compared with the conventional method of wire-linked, which adds wireless transceivers by using the genetic algorithm (GA), the proposed maximal declining sorting algorithm (MDSA) can effectively reduce time consumption by as much as 20.4% to 35.6%. We also evaluate the power consumption and configuration time to prove the effective of the proposed algorithm.

  19. Concentric Circular Grating Generated by the Patterning Trapping of Nanoparticles in an Optofluidic Chip

    Science.gov (United States)

    Dai, Hailang; Cao, Zhuangqi; Wang, Yuxing; Li, Honggen; Sang, Minghuang; Yuan, Wen; Chen, Fan; Chen, Xianfeng

    2016-08-01

    Due to the field enhancement effect of the hollow-core metal-cladded optical waveguide chip, massive nanoparticles in a solvent are effectively trapped via exciting ultrahigh order modes. A concentric ring structure of the trapped nanoparticles is obtained since the excited modes are omnidirectional at small incident angle. During the process of solvent evaporation, the nanoparticles remain well trapped since the excitation condition of the optical modes is still valid, and a concentric circular grating consisting of deposited nanoparticles can be produced by this approach. Experiments via scanning electron microscopy, atomic force microscopy and diffraction of a probe laser confirmed the above hypothesis. This technique provides an alternative strategy to enable effective trapping of dielectric particles with low-intensity nonfocused illumination, and a better understanding of the correlation between the guided modes in an optical waveguide and the nanoparticles in a solvent.

  20. Concentric Circular Grating Generated by the Patterning Trapping of Nanoparticles in an Optofluidic Chip.

    Science.gov (United States)

    Dai, Hailang; Cao, Zhuangqi; Wang, Yuxing; Li, Honggen; Sang, Minghuang; Yuan, Wen; Chen, Fan; Chen, Xianfeng

    2016-08-23

    Due to the field enhancement effect of the hollow-core metal-cladded optical waveguide chip, massive nanoparticles in a solvent are effectively trapped via exciting ultrahigh order modes. A concentric ring structure of the trapped nanoparticles is obtained since the excited modes are omnidirectional at small incident angle. During the process of solvent evaporation, the nanoparticles remain well trapped since the excitation condition of the optical modes is still valid, and a concentric circular grating consisting of deposited nanoparticles can be produced by this approach. Experiments via scanning electron microscopy, atomic force microscopy and diffraction of a probe laser confirmed the above hypothesis. This technique provides an alternative strategy to enable effective trapping of dielectric particles with low-intensity nonfocused illumination, and a better understanding of the correlation between the guided modes in an optical waveguide and the nanoparticles in a solvent.

  1. Generation and transfer of single photons on a photonic crystal chip

    CERN Document Server

    Englund, D; Zhang, B; Yamamoto, Y; Vuckovic, J; Englund, Dirk; Faraon, Andrei; Zhang, Bingyang; Yamamoto, Yoshihisa; Vuckovic, Jelena

    2006-01-01

    We present a basic building block of a quantum network consisting of a quantum dot coupled to a source cavity, which in turn is coupled to a target cavity via a waveguide. The single photon emission from the high-Q/V source cavity is characterized by a twelve-fold spontaneous emission (SE) rate enhancement that results in a SE coupling efficiency near 0.98 into the source cavity mode. Single photons are efficiently transferred into the target cavity through the waveguide, with a source/target field intensity ratio of 0.12 (up to 0.49 observed in other structures without coupled quantum dots). This system shows great promise as a building block of future on-chip quantum information processing systems.

  2. On-Chip Magnetic Bead Manipulation and Detection Using a Magnetoresistive Sensor-Based Micro-Chip: Design Considerations and Experimental Characterization

    Directory of Open Access Journals (Sweden)

    Chinthaka P. Gooneratne

    2016-08-01

    Full Text Available The remarkable advantages micro-chip platforms offer over cumbersome, time-consuming equipment currently in use for bio-analysis are well documented. In this research, a micro-chip that includes a unique magnetic actuator (MA for the manipulation of superparamagnetic beads (SPBs, and a magnetoresistive sensor for the detection of SPBs is presented. A design methodology, which takes into account the magnetic volume of SPBs, diffusion and heat transfer phenomena, is presented with the aid of numerical analysis to optimize the parameters of the MA. The MA was employed as a magnetic flux generator and experimental analysis with commercially available COMPEL™ and Dynabeads® demonstrated the ability of the MA to precisely transport a small number of SPBs over long distances and concentrate SPBs to a sensing site for detection. Moreover, the velocities of COMPEL™ and Dynabead® SPBs were correlated to their magnetic volumes and were in good agreement with numerical model predictions. We found that 2.8 μm Dynabeads® travel faster, and can be attracted to a magnetic source from a longer distance, than 6.2 μm COMPEL™ beads at magnetic flux magnitudes of less than 10 mT. The micro-chip system could easily be integrated with electronic circuitry and microfluidic functions, paving the way for an on-chip biomolecule quantification device.

  3. On-Chip Magnetic Bead Manipulation and Detection Using a Magnetoresistive Sensor-Based Micro-Chip: Design Considerations and Experimental Characterization.

    Science.gov (United States)

    Gooneratne, Chinthaka P; Kodzius, Rimantas; Li, Fuquan; Foulds, Ian G; Kosel, Jürgen

    2016-08-26

    The remarkable advantages micro-chip platforms offer over cumbersome, time-consuming equipment currently in use for bio-analysis are well documented. In this research, a micro-chip that includes a unique magnetic actuator (MA) for the manipulation of superparamagnetic beads (SPBs), and a magnetoresistive sensor for the detection of SPBs is presented. A design methodology, which takes into account the magnetic volume of SPBs, diffusion and heat transfer phenomena, is presented with the aid of numerical analysis to optimize the parameters of the MA. The MA was employed as a magnetic flux generator and experimental analysis with commercially available COMPEL™ and Dynabeads(®) demonstrated the ability of the MA to precisely transport a small number of SPBs over long distances and concentrate SPBs to a sensing site for detection. Moreover, the velocities of COMPEL™ and Dynabead(®) SPBs were correlated to their magnetic volumes and were in good agreement with numerical model predictions. We found that 2.8 μm Dynabeads(®) travel faster, and can be attracted to a magnetic source from a longer distance, than 6.2 μm COMPEL™ beads at magnetic flux magnitudes of less than 10 mT. The micro-chip system could easily be integrated with electronic circuitry and microfluidic functions, paving the way for an on-chip biomolecule quantification device.

  4. On-Chip Magnetic Bead Manipulation and Detection Using a Magnetoresistive Sensor-Based Micro-Chip: Design Considerations and Experimental Characterization

    KAUST Repository

    Gooneratne, Chinthaka P.

    2016-08-26

    The remarkable advantages micro-chip platforms offer over cumbersome, time-consuming equipment currently in use for bio-analysis are well documented. In this research, a micro-chip that includes a unique magnetic actuator (MA) for the manipulation of superparamagnetic beads (SPBs), and a magnetoresistive sensor for the detection of SPBs is presented. A design methodology, which takes into account the magnetic volume of SPBs, diffusion and heat transfer phenomena, is presented with the aid of numerical analysis to optimize the parameters of the MA. The MA was employed as a magnetic flux generator and experimental analysis with commercially available COMPEL™ and Dynabeads® demonstrated the ability of the MA to precisely transport a small number of SPBs over long distances and concentrate SPBs to a sensing site for detection. Moreover, the velocities of COMPEL™ and Dynabead® SPBs were correlated to their magnetic volumes and were in good agreement with numerical model predictions. We found that 2.8 μm Dynabeads® travel faster, and can be attracted to a magnetic source from a longer distance, than 6.2 μm COMPEL™ beads at magnetic flux magnitudes of less than 10 mT. The micro-chip system could easily be integrated with electronic circuitry and microfluidic functions, paving the way for an on-chip biomolecule quantification device

  5. Development of single-chip fuzzy controller based on FFSI in binary

    Institute of Scientific and Technical Information of China (English)

    张吉礼; 欧进萍; 孙德兴

    2003-01-01

    Length and concise structure of fuzzy logic reasoning program and its real-time reasoning characteris-tic have their effect on the performance of a digital single-chip fuzzy controller. The control effect of a digitalfuzzy controller based on looking up fuzzy control responding table is only relative to the table and not relative tothe fuzzy control rules in the practical control process. Aiming at above problem and having combined fuzzy log-ic reasoning with digital operational characteristics of a single-chip microcomputer, functioning-fuzzy-subset in-ference (FFSI) in binary, in which triangle membership functions of error and error-in-change are all represen-ted in binary and singleton membership functions of control variable is binary too, has been introduced. The cir-cuit principle plans of a single-chip fuzzy controller have been introduced for development of its hardware, andthe primary program structure, fuzzy logic reasoning subroutine, serial communication subroutine with PC andreliability design of the fuzzy controller are all discussed in detail. The control of indoor temperature by a fuzzycontroller has been conducted using a testing-room thermodynamic system. Research results show that the FFSIin binary can exercise a concise fuzzy control in a single-chip fuzzy controller, and the fuzzy controller is there-fore reliable and possesses a high performance-price ratio.

  6. Simulation and experimental validation of a SU-8 based PCR thermocycler chip with integrated heaters and temperature sensor

    DEFF Research Database (Denmark)

    El-Ali, Jamil; Perch-Nielsen, Ivan R.; Poulsen, Claus Riber

    2004-01-01

    We present a SU-8 based polymerase chain reaction (PCR) chip with integrated platinum thin film heaters and temperature sensor. The device is fabricated in SU-8 on a glass substrate. The use of SU-8 provides a simple microfabrication process for the PCR chamber, controllable surface properties...... and can allow on chip integration to other SU-8 based functional elements. Finite element modeling (FEM) and experiments show that the temperature distribution in the PCR chamber is homogeneous and that the chip is capable of fast thermal cycling. With heating and cooling rates of up to 50 and 30 degrees...

  7. 39 fJ/bit On-Chip Identification ofWireless Sensors Based on Manufacturing Variation

    Directory of Open Access Journals (Sweden)

    Jonathan F. Bolus

    2014-09-01

    Full Text Available A 39 fJ/bit IC identification system based on FET mismatch is presented and implemented in a 130 nm CMOS process. ID bits are generated based on the ΔVT between identically drawn NMOS devices due to manufacturing variation, and the ID cell structure allows for the characterization of ID bit reliability by characterizing ΔVT . An addressing scheme is also presented that allows for reliable on-chip identification of ICs in the presence of unreliable ID bits. An example implementation is presented that can address 1000 unique ICs, composed of 31 ID bits and having an error rate less than 10-6, with up to 21 unreliable bits.

  8. Debugging systems-on-chip communication-centric and abstraction-based techniques

    CERN Document Server

    Vermeulen, Bart

    2014-01-01

    This book describes an approach and supporting infrastructure to facilitate debugging the silicon implementation of a System-on-Chip (SOC), allowing its associated product to be introduced into the market more quickly.  Readers learn step-by-step the key requirements for debugging a modern, silicon SOC implementation, nine factors that complicate this debugging task, and a new debug approach that addresses these requirements and complicating factors.  The authors’ novel communication-centric, scan-based, abstraction-based, run/stop-based (CSAR) debug approach is discussed in detail, showing how it helps to meet debug requirements and address the nine, previously identified factors that complicate debugging silicon implementations of SOCs. The authors also derive the debug infrastructure requirements to support debugging of a silicon implementation of an SOC with their CSAR debug approach. This debug infrastructure consists of a generic on-chip debug architecture, a configurable automated design-for-debug ...

  9. Trace-Based Code Generation for Model-Based Testing

    NARCIS (Netherlands)

    Kanstrén, T.; Piel, E.; Gross, H.-G.

    2009-01-01

    Paper Submitted for review at the Eighth International Conference on Generative Programming and Component Engineering. Model-based testing can be a powerful means to generate test cases for the system under test. However, creating a useful model for model-based testing requires expertise in the (fo

  10. Large-area photodetector with high-sensitivity and broadband spectral response based on composition-graded CdSSe nanowire-chip

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Shuai; Li, Zhishuang; Song, Guangli; Zou, Bingsuo; Wang, Xiaoxu; Liu, Ruibin, E-mail: liuruibin8@gmail.com

    2015-11-15

    The nanowire-chip based large-area and broad-band-response photodetector was realized by integrating the ternary bandgap-graded CdS{sub 1−x}Se{sub x} nanowire-chip on proper substrate and optimizing electrode pattern. The actual light-to-dark current ratio (I{sub light}/I{sub dark}) is subject to the substrate type and the electrode pattern, as well the thickness of nanowires. Up to 10{sup 6} light-to-dark current ratio was obtained for the nanowire-chip photodetector with the optimized interdigital electrode parameters (0.5 mm in width, 0.5 mm in pitch), the suitable substrate – mica and appropriate nanowire thickness (70um). Although the carriers transmit from light-generated carrier centers to the electrodes through a complicated and long pathway, the photodetector of as-fabricated nanowire-chip shows much higher photocurrent and photoconductivity due to a higher photocarrier densities exist in the ternary compounds than that in binary CdS and CdSe nanowire and the intersection trap state existing between nanowires enhances the separation of electrons and holes. Uniform and broad photoresponse covering from ultraviolet to around 700 nm is attributed to the graded bandgap of different composition nanowires/nanobelts in the chip-type detector. Especially, the I{sub light}/I{sub dark} of nanowire-chip detector increases with the temperature decrease due to the dark noise and the scattering become lower. The chip detector with composition-graded nanowires shows good photoconductivity at room temperature and low temperature. More important, it can be fabricated by a commercial CVD route, which will satisfy the requirements in many application fields instead of Si-based detector. - Highights: • Macroscale photodetector based on CdS{sub 1−x}Se{sub x} nanowire was fabricated. • Broad-spectrum uniform response and high-sensitivity are presented. • At low temperature the photodetector has better photoconductive property. • Photoconductive property dependent

  11. Combining SDM-Based Circuit Switching with Packet Switching in a Router for On-Chip Networks

    Directory of Open Access Journals (Sweden)

    Angelo Kuti Lusala

    2012-01-01

    Full Text Available A Hybrid router architecture for Networks-on-Chip “NoC” is presented, it combines Spatial Division Multiplexing “SDM” based circuit switching and packet switching in order to efficiently and separately handle both streaming and best-effort traffic generated in real-time applications. Furthermore the SDM technique is combined with Time Division Multiplexing “TDM” technique in the circuit switching part in order to increase path diversity, thus improving throughput while sharing communication resources among multiple connections. Combining these two techniques allows mitigating the poor resource usage inherent to circuit switching. In this way Quality of Service “QoS” is easily provided for the streaming traffic through the circuit-switched sub-router while the packet-switched sub-router handles best-effort traffic. The proposed hybrid router architectures were synthesized, placed and routed on an FPGA. Results show that a practicable Network-on-Chip “NoC” can be built using the proposed router architectures. 7 × 7 mesh NoCs were simulated in SystemC. Simulation results show that the probability of establishing paths through the NoC increases with the number of sub-channels and has its highest value when combining SDM with TDM, thereby significantly reducing contention in the NoC.

  12. Partition-based Low Power DFT Methodology for System-on-chips

    Institute of Scientific and Technical Information of China (English)

    LI Yu-fei; CHEN Jian; FU Yu-zhuo

    2007-01-01

    This paper presents a partition-based Design-forTest (DFT) technique to reduce the power consumption during scan-based testing. This method is based on partitioning the chip into several independent scan domains. By enabling the scan domains alternatively, only a fraction of the entire chip will be active at the same time, leading to Iow power consumption during test. Therefore, it will significantly reduce the possibility of Electronic Migration and Overheating. In order to prevent the drop of fault coverage, wrappers on the boundaries between scan domains are employed. This paper also presents a detailed design flow based on Electronics Design Automation(EDA) tools from Synopsy(s) to implement the proposed test structure. The proposed DFT method is experimented on a state-of-theart System-on-chips (SOC). The simulation results show a significant reduction in both average and peak power dissipation without sacrificing the fault coverage and test time. This SOC has been taped out in TSMC and finished the final test in ADVANTEST.

  13. Signal Detection of Multi-Channel Capillary Electrophoresis Chip Based on CCD

    Science.gov (United States)

    Lv, Hongfeng; Yan, Weiping; Yang, Xiaobo; Li, Jiechao; Zhu, Jieying

    2012-12-01

    A kind of multi-channel capillary electrophoresis (CE) chip signal detection system based on CCD was developed. The output signal of the CCD sensor was processed by a series of pre-processing circuits and ADC, and then it was collected by the Field Programmable Gate Array (FPGA) chip which communicated with a host computer. The core in FPGA was designed to control the signal flow of the CCD and transfer the data to PC based on a Nios II embedded soft-processor. The application of PC was used to store the data and demonstrate the curve. The measurement of the fluorescent signals for different concentration Rhodamine B dyes is presented and the comparison with other detection systems is also discussed.

  14. On-chip magnetic bead-based DNA melting curve analysis using a magnetoresistive sensor

    DEFF Research Database (Denmark)

    Rizzi, Giovanni; Østerberg, Frederik Westergaard; Henriksen, Anders Dahl

    2014-01-01

    of the differential sensor geometry. The sensor surfaces are functionalized with wild type (WT) and mutant type (MT) capture probes, differing by a single base insertion (a single nucleotide polymorphism, SNP). Complementary biotinylated targets in suspension couple streptavidin magnetic beads to the sensor surface......We present real-time measurements of DNA melting curves in a chip-based system that detects the amount of surface-bound magnetic beads using magnetoresistive magnetic field sensors. The sensors detect the difference between the amount of beads bound to the top and bottom sensor branches....... The beads are magnetized by the field arising from the bias current passed through the sensors. We demonstrate the first on-chip measurements of the melting of DNA hybrids upon a ramping of the temperature. This overcomes the limitation of using a single washing condition at constant temperature. Moreover...

  15. On-chip magnetic bead-based DNA melting curve analysis using a magnetoresistive sensor

    Science.gov (United States)

    Rizzi, Giovanni; Østerberg, Frederik W.; Henriksen, Anders D.; Dufva, Martin; Hansen, Mikkel F.

    2015-04-01

    We present real-time measurements of DNA melting curves in a chip-based system that detects the amount of surface-bound magnetic beads using magnetoresistive magnetic field sensors. The sensors detect the difference between the amount of beads bound to the top and bottom sensor branches of the differential sensor geometry. The sensor surfaces are functionalized with wild type (WT) and mutant type (MT) capture probes, differing by a single base insertion (a single nucleotide polymorphism, SNP). Complementary biotinylated targets in suspension couple streptavidin magnetic beads to the sensor surface. The beads are magnetized by the field arising from the bias current passed through the sensors. We demonstrate the first on-chip measurements of the melting of DNA hybrids upon a ramping of the temperature. This overcomes the limitation of using a single washing condition at constant temperature. Moreover, we demonstrate that a single sensor bridge can be used to genotype a SNP.

  16. Highly efficient fiber-to-chip evanescent coupling based on subwavelength-diameter optical fibers

    Institute of Scientific and Technical Information of China (English)

    Xiaowei Shen; Xinwan Li; Lijie Zhou; Zehua Hong; Xiaocao Yu; Ying Zhang; Jianping Chen

    2011-01-01

    @@ A novel, compact, and highly efficient fiber-to-chip evanescent coupling structure is proposed based on a subwavelength-diameter fiber.The coupling structure is characterized by a large misalignment tolerance and easy fabrication.The dependence of coupling efficiency on various parameters is calculated and analyzed.%A novel, compact, and highly efficient fiber-to-chip evanescent coupling structure is proposed based on a subwavelength-diameter fiber. The coupling structure is characterized by a large misalignment tolerance and easy fabrication. The dependence of coupling efficiency on various parameters is calculated and analyzed. The simulation results show that a coupling efficiency as high as 95% can be obtained within a coupling length of <4 μm.

  17. Polarization-, carrier-, and format-selectable optical flow generation based on a multi-flow transmitter using passive polymers

    DEFF Research Database (Denmark)

    Katopodis, V.; Spyropoulou, M.; Tsokos, C.;

    2016-01-01

    . Multiflow operation is realized by two polymer boards allowing optical carrier management and optional polarization multiplexing on chip. Optical carrier generation is performed also on chip using three tunable InP gain chips hybridly integrated on the input polyboard. Single and dual optical flow...

  18. An Energy-Efficient High-Throughput Mesh-Based Photonic On-Chip Interconnect for Many-Core Systems

    OpenAIRE

    Achraf Ben Ahmed; Abderazek Ben Abdallah

    2016-01-01

    Future high-performance embedded and general purpose processors and systems-on-chip are expected to combine hundreds of cores integrated together to satisfy the power and performance requirements of large complex applications. As the number of cores continues to increase, the employment of low-power and high-throughput on-chip interconnect fabrics becomes imperative. In this work, we present a novel mesh-based photonic on-chip interconnect, named PHENIC-II, for future high-performance many-co...

  19. Sample processing for DNA chip array-based analysis of enterohemorrhagic Escherichia coli (EHEC)

    OpenAIRE

    Enfors Sven-Olof; Wegrzyn Grzegorz; Basselet Pascal; Gabig-Ciminska Magdalena

    2008-01-01

    Abstract Background Exploitation of DNA-based analyses of microbial pathogens, and especially simultaneous typing of several virulence-related genes in bacteria is becoming an important objective of public health these days. Results A procedure for sample processing for a confirmative analysis of enterohemorrhagic Escherichia coli (EHEC) on a single colony with DNA chip array was developed and is reported here. The protocol includes application of fragmented genomic DNA from ultrasonicated co...

  20. Single-bead arrays for fluorescence-based immunoassays on capillary-driven microfluidic chips

    Science.gov (United States)

    Temiz, Yuksel; Lim, Michel; Delamarche, Emmanuel

    2016-03-01

    We report a concept for the simple fabrication of easy-to-use chips for immunoassays in the context of point-of-care diagnostics. The chip concept comprises mainly three features: (1) the efficient integration of reagents using beads functionalized with receptors, (2) the generation of capillary-driven liquid flows without using external pumps, and (3) a high-sensitivity detection of analytes using fluorescence microscopy. We fabricated prototype chips using dry etching of Si wafers. 4.5-μm-diameter beads were integrated into hexagonal arrays by sedimentation and removing the excess using a stream of water. We studied the effect of different parameters and showed that array occupancies from 30% to 50% can be achieved by pipetting a 250 nL droplet of 1% bead solution and allowing the beads sediment for 3 min. Chips with integrated beads were sealed using a 50-μm-thick dry-film resist laminated at 45 °C. Liquids pipetted to loading pads were autonomously pulled by capillary pumps at a rate of 0.35 nL s-1 for about 30 min. We studied ligand-receptor interactions and binding kinetics using time-lapse fluorescence microscopy and demonstrated a 5 pM limit of detection (LOD) for an anti-biotin immunoassay. As a clinically-relevant example, we implemented an immunoassay to detect prostate specific antigen (PSA) and showed an LOD of 108 fM (i.e. 3.6 pg mL-1). While a specific implementation is provided here for the detection of PSA, we believe that combining capillary-driven microfluidics with arrays of single beads and fluorescence readout to be very flexible and sufficiently sensitive for the detection of other clinically-relevant analytes.

  1. Demonstration of a chip-based optical isolator with parametric amplification

    Science.gov (United States)

    Hua, Shiyue; Wen, Jianming; Jiang, Xiaoshun; Hua, Qian; Jiang, Liang; Xiao, Min

    2016-11-01

    Despite being fundamentally challenging in integrated (nano)photonics, achieving chip-based light non-reciprocity becomes increasingly urgent in signal processing and optical communications. Because of material incompatibilities in conventional approaches based on the Faraday effect, alternative solutions have resorted to nonlinear processes to obtain one-way transmission. However, dynamic reciprocity in a recent theoretical analysis has pinned down the functionalities of these nonlinear isolators. To bypass such dynamic reciprocity, we here demonstrate an optical isolator on a silicon chip enforced by phase-matched parametric amplification in four-wave mixing. Using a high-Q microtoroid resonator, we realize highly non-reciprocal transport at the 1,550 nm wavelength when waves are injected from both directions in two different operating configurations. Our design, compatible with current complementary metal-oxide-semiconductor (CMOS) techniques, yields convincing isolation performance with sufficiently low insertion loss for a wide range of input power levels. Moreover, our work demonstrates the possibility of designing chip-based magnetic-free optical isolators for information processing and laser protection.

  2. Sample processing for DNA chip array-based analysis of enterohemorrhagic Escherichia coli (EHEC

    Directory of Open Access Journals (Sweden)

    Enfors Sven-Olof

    2008-10-01

    Full Text Available Abstract Background Exploitation of DNA-based analyses of microbial pathogens, and especially simultaneous typing of several virulence-related genes in bacteria is becoming an important objective of public health these days. Results A procedure for sample processing for a confirmative analysis of enterohemorrhagic Escherichia coli (EHEC on a single colony with DNA chip array was developed and is reported here. The protocol includes application of fragmented genomic DNA from ultrasonicated colonies. The sample processing comprises first 2.5 min of ultrasonic treatment, DNA extraction (2×, and afterwards additional 5 min ultrasonication. Thus, the total sample preparation time for a confirmative analysis of EHEC is nearly 10 min. Additionally, bioinformatic revisions were performed in order to design PCR primers and array probes specific to most conservative regions of the EHEC-associated genes. Six strains with distinct pathogenic properties were selected for this study. At last, the EHEC chip array for a parallel and simultaneous detection of genes etpC-stx1-stx2-eae was designed and examined. This should permit to sense all currently accessible variants of the selected sequences in EHEC types and subtypes. Conclusion In order to implement the DNA chip array-based analysis for direct EHEC detection the sample processing was established in course of this work. However, this sample preparation mode may also be applied to other types of EHEC DNA-based sensing systems.

  3. Integrated polymerase chain reaction chips utilizing digital microfluidics.

    Science.gov (United States)

    Chang, Yi-Hsien; Lee, Gwo-Bin; Huang, Fu-Chun; Chen, Yi-Yu; Lin, Jr-Lung

    2006-09-01

    This study reports an integrated microfluidic chip for polymerase chain reaction (PCR) applications utilizing digital microfluidic chip (DMC) technology. Several crucial procedures including sample transportation, mixing, and DNA amplification were performed on the integrated chip using electro-wetting-on-dielectric (EWOD) effect. An innovative concept of hydrophobic/hydrophilic structure has been successfully demonstrated to integrate the DMC chip with the on-chip PCR device. Sample droplets were generated, transported and mixed by the EWOD-actuation. Then the mixture droplets were transported to a PCR chamber by utilizing the hydrophilic/hydrophobic interface to generate required surface tension gradient. A micro temperature sensor and two micro heaters inside the PCR chamber along with a controller were used to form a micro temperature control module, which could perform precise PCR thermal cycling for DNA amplification. In order to demonstrate the performance of the integrated DMC/PCR chips, a detection gene for Dengue II virus was successfully amplified and detected. The new integrated DMC/PCR chips only required an operation voltage of 12V(RMS) at a frequency of 3 KHz for digital microfluidic actuation and 9V(DC) for thermal cycling. When compared to its large-scale counterparts for DNA amplification, the developed system consumed less sample and reagent and could reduce the detection time. The developed chips successfully demonstrated the feasibility of Lab-On-a-Chip (LOC) by utilizing EWOD-based digital microfluidics.

  4. Extraction, amplification and detection of DNA in microfluidic chip-based assays

    KAUST Repository

    Wu, Jinbo

    2013-12-20

    This review covers three aspects of PCR-based microfluidic chip assays: sample preparation, target amplification, and product detection. We also discuss the challenges related to the miniaturization and integration of each assay and make a comparison between conventional and microfluidic schemes. In order to accomplish these essential assays without human intervention between individual steps, the micro-components for fluid manipulation become critical. We therefore summarize and discuss components such as microvalves (for fluid regulation), pumps (for fluid driving) and mixers (for blending fluids). By combining the above assays and microcomponents, DNA testing of multi-step bio-reactions in microfluidic chips may be achieved with minimal external control. The combination of assay schemes with the use of micro-components also leads to rapid methods for DNA testing via multi-step bioreactions. Contains 259 references.

  5. Low latency on chip communication based on hybrid NOC Architecture using X-Y router

    Directory of Open Access Journals (Sweden)

    Tejas wini Deotare

    2014-05-01

    Full Text Available On-chip co mmunication has two different type of architecture which can be classified as Bus and mesh based Networks- on-Chip (No C. Each of them has diffe rent features and applications. In this paper, we construct the hybrid architecture with using bus and mesh NOC architecture. In the hybrid architecture, heavy communication affinity IPcores are placed in the same subsystem. and this large mesh No C get partitioned into several subsystems and one on one individual IPs, so that there is the reduction in the transmission latency of NoC.Efficient partition and mapping algorith m is proposed for reduction of the latency on the hybrid NOC arch itecture.It shows that an average latency improvement of 17.6% and more can be obtained when compared with the conventional mesh No C arch itecture.

  6. Lab-on-chip for liquid biopsy (LoC-LB) based on dielectrophoresis.

    Science.gov (United States)

    Mathew, Bobby; Alazzam, Anas; Khashan, Saud; Abutayeh, Mohammad

    2017-03-01

    This short communication presents the proof-of-concept of a novel dielectrophoretic lab-on-chip for identifying/separating circulating tumor cells for purposes of liquid biopsy. The device consists of a polydimethylsiloxane layer, containing a microchannel, bonded on a glass substrate that holds two sets of planar interdigitated transducer electrodes. The lab-on-chip is operated at a frequency that enables dielectrophoretic force to sort cells, based on type, along the lateral direction. The operating frequency ensures attraction force toward the electrodes on cancer cells and repulsion force toward the center of the microchannel on other cells. Initial tests for demonstrating proof-of-concept have successfully identified/separated green fluorescent protein-labelled MDA-MB-231 breast cancer cells from a mixture of the same and regular blood cells suspended in low conductivity sucrose/dextrose medium.

  7. A CDMA Based Scalable Hierarchical Architecture for Network-On-Chip

    Directory of Open Access Journals (Sweden)

    Mohamed A. Abd El Ghany

    2012-09-01

    Full Text Available A Scalable hierarchical architecture based Code-Division Multiple Access (CDMA is proposed for high performance Network-on-Chip (NoC. This hierarchical architecture provides the integration of a large number of IPs in a single on-chip system. The network encoding and decoding schemes for CDMA transmission are provided. The proposed CDMA NoC architecture is compared to the conventional architecture in terms of latency, area and power dissipation. The overall area required to implement the proposed CDMA NoC design is reduced by 24.2%. The design decreases the latency of the network by 40%. The total power consumption required to achieve the proposed design is also decreased by 25%.

  8. Enhancing SAT-Based Test Pattern Generation

    Institute of Scientific and Technical Information of China (English)

    LIU Xin; XIONG You-lun

    2005-01-01

    This paper presents modeling tools based on Boolean satisfiability (SAT) to solve problems of test generation for combinational circuits. It exploits an added layer to maintain circuit-related information and value justification relations to a generic SAT algorithm. It dovetails binary decision graphs (BDD) and SAT techniques to improve the efficiency of automatic test pattern generation (ATPG). More specifically, it first exploits inexpensive reconvergent fanout analysis of circuit to gather information on the local signal correlation by using BDD learning, then uses the above learned information to restrict and focus the overall search space of SAT-based ATPG. Its learning technique is effective and lightweight. The experimental results demonstrate the effectiveness of the approach.

  9. ALGORITHM FOR GENERATING DEM BASED ON CONE

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Digital elevation model (DEM) has a variety of applications in GIS and CAD.It is the basic model for generating three-dimensional terrain feature.Generally speaking,there are two methods for building DEM.One is based upon the digital terrain model of discrete points,and is characterized by fast speed and low precision.The other is based upon triangular digital terrain model,and slow speed and high precision are the features of the method.Combining the advantages of the two methods,an algorithm for generating DEM with discrete points is presented in this paper.When interpolating elevation,this method can create a triangle which includes interpolating point and the elevation of the interpolating point can be obtained from the triangle.The method has the advantage of fast speed,high precision and less memory.

  10. Web Services-Based Test Report Generation

    Institute of Scientific and Technical Information of China (English)

    LUO Ling; BAI Xiaoying

    2005-01-01

    Tests involving a large number of test cases and test scenarios are always time- and effort-intensive, and use ad hoc approaches. Test management is needed to control the complexity and the quality of the testing of large software systems. The reporting mechanism is critical for monitoring the testing progress, analyzing test results, and evaluating the test effectiveness for a disciplined testing process throughout the testing lifecycle. This paper presents an XML-based report generation method for large system testing. The service-oriented architecture enables flexible test report generation, presentation, and exchange to facilitate collaboration in a distributed environment. The results show that proper reporting can effectively improve the visibility of the testing process and that this web-based approach is critical to enhance communication among multiple testing groups.

  11. Phase-matched second harmonic generation with on-chip GaN-on-Si microdisks

    Science.gov (United States)

    Roland, I.; Gromovyi, M.; Zeng, Y.; El Kurdi, M.; Sauvage, S.; Brimont, C.; Guillet, T.; Gayral, B.; Semond, F.; Duboz, J. Y.; de Micheli, M.; Checoury, X.; Boucaud, P.

    2016-09-01

    We demonstrate phase-matched second harmonic generation in gallium nitride on silicon microdisks. The microdisks are integrated with side-coupling bus waveguides in a two-dimensional photonic circuit. The second harmonic generation is excited with a continuous wave laser in the telecom band. By fabricating a series of microdisks with diameters varying by steps of 8 nm, we obtain a tuning of the whispering gallery mode resonances for the fundamental and harmonic waves. Phase matching is obtained when both resonances are matched with modes satisfying the conservation of orbital momentum, which leads to a pronounced enhancement of frequency conversion.

  12. Phase-matched second harmonic generation with on-chip GaN-on-Si microdisks

    Science.gov (United States)

    Roland, I.; Gromovyi, M.; Zeng, Y.; El Kurdi, M.; Sauvage, S.; Brimont, C.; Guillet, T.; Gayral, B.; Semond, F.; Duboz, J. Y.; de Micheli, M.; Checoury, X.; Boucaud, P.

    2016-01-01

    We demonstrate phase-matched second harmonic generation in gallium nitride on silicon microdisks. The microdisks are integrated with side-coupling bus waveguides in a two-dimensional photonic circuit. The second harmonic generation is excited with a continuous wave laser in the telecom band. By fabricating a series of microdisks with diameters varying by steps of 8 nm, we obtain a tuning of the whispering gallery mode resonances for the fundamental and harmonic waves. Phase matching is obtained when both resonances are matched with modes satisfying the conservation of orbital momentum, which leads to a pronounced enhancement of frequency conversion. PMID:27687007

  13. Source Code Generator Based on Dynamic Frames

    Directory of Open Access Journals (Sweden)

    Danijel Radošević

    2011-06-01

    Full Text Available Normal 0 21 false false false HR X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Obična tablica"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} This paper presents the model of source code generator based on dynamic frames. The model is named as the SCT model because if its three basic components: Specification (S, which describes the application characteristics, Configuration (C, which describes the rules for building applications, and Templates (T, which refer to application building blocks. The process of code generation dynamically creates XML frames containing all building elements (S, C ant T until final code is produced. This approach is compared to existing XVCL frames based model for source code generating. The SCT model is described by both XML syntax and the appropriate graphical elements. The SCT model is aimed to build complete applications, not just skeletons. The main advantages of the presented model are its textual and graphic description, a fully configurable generator, and the reduced overhead of the generated source code. The presented SCT model is shown on development of web application example in order to demonstrate its features and justify our design choices.

  14. On-chip generation of Einstein-Podolsky-Rosen states with arbitrary symmetry

    Energy Technology Data Exchange (ETDEWEB)

    Gräfe, Markus; Heilmann, René; Nolte, Stefan; Szameit, Alexander, E-mail: alexander.szameit@uni-jena.de [Institute of Applied Physics, Abbe Center of Photonics, Friedrich-Schiller-Universität, Max-Wien-Platz 1, 07743 Jena (Germany)

    2015-05-04

    We experimentally demonstrate a method for integrated-optical generation of two-photon Einstein-Podolsky-Rosen states featuring arbitrary symmetries. In our setting, we employ detuned directional couplers to impose a freely tailorable phase between the two modes of the state. Our results allow to mimic the quantum random walk statistics of bosons, fermions, and anyons, particles with fractional exchange statistics.

  15. Fiber-to-Waveguide and 3D Chip-to-Chip Light Coupling Based on Bent Metal-Clad Waveguides

    CERN Document Server

    Lu, Zhaolin; Shi, Kaifeng

    2016-01-01

    Efficient fiber-to-waveguide light coupling has been a key issue in integrated photonics for many years. The main challenge lies in the huge mode mismatch between an optical fiber and a single mode waveguide. Herein, we present a novel fiber-to-waveguide coupler, named "L-coupler", through which the light fed from the top of a chip can bend 90{\\deg} with low reflection and is then efficiently coupled into an on-chip Si waveguide within a short propagation distance (<20{\\mu}m). The key element is a bent metal-clad waveguide with a big matched input port. According to our finite-difference time-domain (FDTD) simulation, the coupling efficiency is over 80% within a broad range of working wavelengths in the near-infrared regime for a transverse electric input Gaussian wave. The coupler is polarization-dependent, with very low coupling efficiency (6%-9%) for transverse magnetic waves. The coupler can also be used for three-dimensional (3D) chip-to-chip optical interconnection by efficiently coupling light into ...

  16. VLSI design of an RSA encryption/decryption chip using systolic array based architecture

    Science.gov (United States)

    Sun, Chi-Chia; Lin, Bor-Shing; Jan, Gene Eu; Lin, Jheng-Yi

    2016-09-01

    This article presents the VLSI design of a configurable RSA public key cryptosystem supporting the 512-bit, 1024-bit and 2048-bit based on Montgomery algorithm achieving comparable clock cycles of current relevant works but with smaller die size. We use binary method for the modular exponentiation and adopt Montgomery algorithm for the modular multiplication to simplify computational complexity, which, together with the systolic array concept for electric circuit designs effectively, lower the die size. The main architecture of the chip consists of four functional blocks, namely input/output modules, registers module, arithmetic module and control module. We applied the concept of systolic array to design the RSA encryption/decryption chip by using VHDL hardware language and verified using the TSMC/CIC 0.35 m 1P4 M technology. The die area of the 2048-bit RSA chip without the DFT is 3.9 × 3.9 mm2 (4.58 × 4.58 mm2 with DFT). Its average baud rate can reach 10.84 kbps under a 100 MHz clock.

  17. HARDWARE IMPLEMENTATION OF PIPELINE BASED ROUTER DESIGN FOR ON-CHIP NETWORK

    Directory of Open Access Journals (Sweden)

    U. Saravanakumar

    2012-12-01

    Full Text Available As the feature size is continuously decreasing and integration density is increasing, interconnections have become a dominating factor in determining the overall quality of a chip. Due to the limited scalability of system bus, it cannot meet the requirement of current System-on-Chip (SoC implementations where only a limited number of functional units can be supported. Long global wires also cause many design problems, such as routing congestion, noise coupling, and difficult timing closure. Network-on-Chip (NoC architectures have been proposed to be an alternative to solve the above problems by using a packet-based communication network. In this paper, the Circuit-Switched (CS Router was designed and analysed the various parameters such as power, timing and area. The CS router has taken more number of cycles to transfer the data from source to destination. So the pipelining concept was implemented by adding registers in the CS router architecture. The proposed architecture increases the speed of operation and reduces the critical path of the circuit. The router has been implemented using Verilog HDL. The parameters area, power and timing were calculated in 130 nm CMOS technology using Synopsys tool with nominal operating voltage of 1V and packet size is 39 bits. Finally power, area and time of these two routers have been analysed and compared.

  18. Chip implementation with a combined wireless temperature sensor and reference devices based on the DZTC principle.

    Science.gov (United States)

    Chang, Ming-Hui; Huang, Yu-Jie; Huang, Han-Pang; Lu, Shey-Shi

    2011-01-01

    This paper presents a novel CMOS wireless temperature sensor design in order to improve the sensitivity and linearity of our previous work on such devices. Based on the principle of CMOS double zero temperature coefficient (DZTC) points, a combined device is first created at the chip level with two voltage references, one current reference, and one temperature sensor. It was successfully fabricated using the 0.35 μm CMOS process. According to the chip results in a wide temperature range from -20 °C to 120 °C, two voltage references can provide temperature-stable outputs of 823 mV and 1,265 mV with maximum deviations of 0.2 mV and 8.9 mV, respectively. The result for the current reference gives a measurement of 23.5 μA, with a maximum deviation of 1.2 μA. The measurements also show that the wireless temperature sensor has good sensitivity of 9.55 mV/°C and high linearity of 97%. The proposed temperature sensor has 4.15-times better sensitivity than the previous design. Moreover, to facilitate temperature data collection, standard wireless data transmission is chosen; therefore, an 8-bit successive-approximation-register (SAR) analog-to-digital converter (ADC) and a 433 MHz wireless transmitter are also integrated in this chip. Sensing data from different places can be collected remotely avoiding the need for complex wire lines.

  19. HPV Direct Flow CHIP: a new human papillomavirus genotyping method based on direct PCR from crude-cell extracts.

    Science.gov (United States)

    Herraez-Hernandez, Elsa; Alvarez-Perez, Martina; Navarro-Bustos, Gloria; Esquivias, Javier; Alonso, Sonia; Aneiros-Fernandez, Jose; Lacruz-Pelea, Cesar; Sanchez-Aguera, Magdalena; Santamaria, Javier Saenz; de Antonio, Jesus Chacon; Rodriguez-Peralto, Jose Luis

    2013-10-01

    HPV Direct Flow CHIP is a newly developed test for identifying 18 high-risk and 18 low-risk human papillomavirus (HPV) genotypes. It is based on direct PCR from crude-cell extracts, automatic flow-through hybridization, and colorimetric detection. The aim of this study was to evaluate the performance of HPV Direct Flow CHIP in the analysis of 947 samples from routine cervical screening or the follow-up of abnormal Pap smears. The specimens were dry swab samples, liquid-based cytology samples, or formalin-fixed paraffin-embedded tissues. The genotype distribution was in agreement with known epidemiological data for the Spanish population. Three different subgroups of the samples were also tested by Linear Array (LA) HPV Genotyping Test (n=108), CLART HPV2 (n=82), or Digene Hybrid Capture 2 (HC2) HPV DNA Test (n=101). HPV positivity was 73.6% by HPV Direct Flow CHIP versus 67% by LA, 65.9% by HPV Direct Flow CHIP versus 59.8% by CLART, and 62.4% by HPV Direct Flow CHIP versus 42.6% by HC2. HPV Direct Flow CHIP showed a positive agreement of 88.6% with LA (k=0.798), 87.3% with CLART (k=0.818), and 68.2% with HC2 (k=0.618). In conclusion, HPV Direct Flow CHIP results were comparable with those of the other methods tested. Although further investigation is needed to compare the performance of this new test with a gold-standard reference method, these preliminary findings evidence the potential value of HPV Direct Flow CHIP in HPV vaccinology and epidemiology studies.

  20. Virus-based piezoelectric energy generation.

    Science.gov (United States)

    Lee, Byung Yang; Zhang, Jinxing; Zueger, Chris; Chung, Woo-Jae; Yoo, So Young; Wang, Eddie; Meyer, Joel; Ramesh, Ramamoorthy; Lee, Seung-Wuk

    2012-05-13

    Piezoelectric materials can convert mechanical energy into electrical energy, and piezoelectric devices made of a variety of inorganic materials and organic polymers have been demonstrated. However, synthesizing such materials often requires toxic starting compounds, harsh conditions and/or complex procedures. Previously, it was shown that hierarchically organized natural materials such as bones, collagen fibrils and peptide nanotubes can display piezoelectric properties. Here, we demonstrate that the piezoelectric and liquid-crystalline properties of M13 bacteriophage (phage) can be used to generate electrical energy. Using piezoresponse force microscopy, we characterize the structure-dependent piezoelectric properties of the phage at the molecular level. We then show that self-assembled thin films of phage can exhibit piezoelectric strengths of up to 7.8 pm V(-1). We also demonstrate that it is possible to modulate the dipole strength of the phage, hence tuning the piezoelectric response, by genetically engineering the major coat proteins of the phage. Finally, we develop a phage-based piezoelectric generator that produces up to 6 nA of current and 400 mV of potential and use it to operate a liquid-crystal display. Because biotechnology techniques enable large-scale production of genetically modified phages, phage-based piezoelectric materials potentially offer a simple and environmentally friendly approach to piezoelectric energy generation.

  1. Virus-based piezoelectric energy generation

    Science.gov (United States)

    Lee, Byung Yang; Zhang, Jinxing; Zueger, Chris; Chung, Woo-Jae; Yoo, So Young; Wang, Eddie; Meyer, Joel; Ramesh, Ramamoorthy; Lee, Seung-Wuk

    2012-06-01

    Piezoelectric materials can convert mechanical energy into electrical energy, and piezoelectric devices made of a variety of inorganic materials and organic polymers have been demonstrated. However, synthesizing such materials often requires toxic starting compounds, harsh conditions and/or complex procedures. Previously, it was shown that hierarchically organized natural materials such as bones, collagen fibrils and peptide nanotubes can display piezoelectric properties. Here, we demonstrate that the piezoelectric and liquid-crystalline properties of M13 bacteriophage (phage) can be used to generate electrical energy. Using piezoresponse force microscopy, we characterize the structure-dependent piezoelectric properties of the phage at the molecular level. We then show that self-assembled thin films of phage can exhibit piezoelectric strengths of up to 7.8 pm V-1. We also demonstrate that it is possible to modulate the dipole strength of the phage, hence tuning the piezoelectric response, by genetically engineering the major coat proteins of the phage. Finally, we develop a phage-based piezoelectric generator that produces up to 6 nA of current and 400 mV of potential and use it to operate a liquid-crystal display. Because biotechnology techniques enable large-scale production of genetically modified phages, phage-based piezoelectric materials potentially offer a simple and environmentally friendly approach to piezoelectric energy generation.

  2. Support for Programming Models in Network-on-Chip-based Many-core Systems

    DEFF Research Database (Denmark)

    Rasmussen, Morten Sleth

    and scalability in an image processing application with the aim of providing insight into parallel programming issues. The second part proposes and presents the tile-based Clupea many-core architecture, which has the objective of providing configurable support for programming models to allow different programming......This thesis addresses aspects of support for programming models in Network-on- Chip-based many-core architectures. The main focus is to consider architectural support for a plethora of programming models in a single system. The thesis has three main parts. The first part considers parallelization...

  3. Lab-on-a-chip technologies for single-molecule studies.

    Science.gov (United States)

    Zhao, Yanhui; Chen, Danqi; Yue, Hongjun; French, Jarrod B; Rufo, Joseph; Benkovic, Stephen J; Huang, Tony Jun

    2013-06-21

    Recent developments on various lab-on-a-chip techniques allow miniaturized and integrated devices to perform on-chip single-molecule studies. Fluidic-based platforms that utilize unique microscale fluidic behavior are capable of conducting single-molecule experiments with high sensitivities and throughputs, while biomolecular systems can be studied on-chip using techniques such as DNA curtains, magnetic tweezers, and solid-state nanopores. The advances of these on-chip single-molecule techniques lead to next-generation lab-on-a-chip devices, such as DNA transistors, and single-molecule real-time (SMRT) technology for rapid and low-cost whole genome DNA sequencing. In this Focus article, we will discuss some recent successes in the development of lab-on-a-chip techniques for single-molecule studies and expound our thoughts on the near future of on-chip single-molecule studies.

  4. Graphene Plasmonic Waveguides for Mid-Infrared Supercontinuum Generation on a Chip

    Directory of Open Access Journals (Sweden)

    Andrey V. Gorbach

    2015-07-01

    Full Text Available Using perturbation expansion of Maxwell equations with the nonlinear boundary condition, a generic propagation equation is derived to describe nonlinear effects, including spectral broadening of pulses, in graphene surface plasmon (GSP waveguides. A considerable spectral broadening of an initial 100 fs pulse with 0.5 mW peak power in a 25 nm wide and 150 nm long waveguide is demonstrated. The generated supercontinuum covers the spectral range from 6 μm to 13 μm .

  5. Differentiation of Wines Treated with Wood Chips Based on Their Phenolic Content, Volatile Composition, and Sensory Parameters.

    Science.gov (United States)

    Kyraleou, Maria; Kallithraka, Stamatina; Chira, Kleopatra; Tzanakouli, Eleni; Ligas, Ioannis; Kotseridis, Yorgos

    2015-12-01

    The effects of both wood chips addition and contact time on phenolic content, volatile composition, color parameters, and organoleptic character of red wine made by a native Greek variety (Agiorgitiko) were evaluated. For this purpose, chips from American, French, Slavonia oak, and Acacia were added in the wine after fermentation. A mixture consisting of 50% French and 50% Americal oak chips was also evaluated. In an attempt to categorize wine samples, various chemical parameters of wines and sensory parameters were studied after 1, 2, and 3 mo of contact time with chips. The results showed that regardless of the type of wood chips added in the wines, it was possible to differentiate the samples according to the contact time based on their phenolic composition and color parameters. In addition, wood-extracted volatile compounds seem to be the critical parameter that could separate the samples according to the wood type. The wines that were in contact with Acacia and Slavonia chips could be separated from the rest mainly due to their distinct sensory characters.

  6. Component-Based Cartoon Face Generation

    Directory of Open Access Journals (Sweden)

    Saman Sepehri Nejad

    2016-11-01

    Full Text Available In this paper, we present a cartoon face generation method that stands on a component-based facial feature extraction approach. Given a frontal face image as an input, our proposed system has the following stages. First, face features are extracted using an extended Active Shape Model. Outlines of the components are locally modified using edge detection, template matching and Hermit interpolation. This modification enhances the diversity of output and accuracy of the component matching required for cartoon generation. Second, to bring cartoon-specific features such as shadows, highlights and, especially, stylish drawing, an array of various face photographs and corresponding hand-drawn cartoon faces are collected. These cartoon templates are automatically decomposed into cartoon components using our proposed method for parameterizing cartoon samples, which is fast and simple. Then, using shape matching methods, the appropriate cartoon component is selected and deformed to fit the input face. Finally, a cartoon face is rendered in a vector format using the rendering rules of the selected template. Experimental results demonstrate effectiveness of our approach in generating life-like cartoon faces.

  7. Ultrafast pulse generation in a mode-locked Erbium chip waveguide laser

    CERN Document Server

    Khurmi, Champak; Zhang, Wen Qi; V., Shahraam Afshar; Chen, George; Genest, Jérôme; Monro, Tanya M; Lancaster, David G

    2016-01-01

    We report mode-locked ~1550 nm output of transform-limited ~180 fs pulses from a large mode-area (diameter ~ 50 {\\mu}m) guided-wave erbium fluorozirconate glass laser. The passively mode-locked oscillator generates pulses with 25 nm bandwidth at 156 MHz repetition rate and peak-power of 260 W. Scalability to higher repetition rate is demonstrated by transform-limited 410 fs pulse output at 1.3 GHz. To understand the origins of the broad spectral output, the laser cavity is simulated by using a numerical solution to the Ginzburg-Landau equation. This paper reports the widest bandwidth and shortest pulses achieved from an ultra-fast laser inscribed waveguide laser.

  8. SOI based integrated on-chip photonic pressure sensor

    NARCIS (Netherlands)

    Chakkalakkal Abdulla, S.M.C.; Harmsma, P.J.; Nieuwland, R.A.; Pozo Torres, J.M.; Lemmen, M.H.J.; Sadeghian Marnani, H.; Berg, J.H. van den; Bodis, P.

    2012-01-01

    A compact, mass producible Silicon On Insulator (SOI) based pressure sensor consisting of a folded Micro Ring Resonator (MRR) on a circular diaphragm is successfully designed, fabricated and characterized [1-3]. The MRR is designed to be single mode for TE polarized light at 1550 nm. The folded MRR

  9. Chip-based device for parallel sorting, amplification, detection, and identification of nucleic acid subsequences

    Energy Technology Data Exchange (ETDEWEB)

    Beer, Neil Reginald; Colston, Jr, Billy W.

    2016-08-09

    An apparatus for chip-based sorting, amplification, detection, and identification of a sample having a planar substrate. The planar substrate is divided into cells. The cells are arranged on the planar substrate in rows and columns. Electrodes are located in the cells. A micro-reactor maker produces micro-reactors containing the sample. The micro-reactor maker is positioned to deliver the micro-reactors to the planar substrate. A microprocessor is connected to the electrodes for manipulating the micro-reactors on the planar substrate. A detector is positioned to interrogate the sample contained in the micro-reactors.

  10. Turbo NOC: a framework for the design of Network On Chip based turbo decoder architectures

    CERN Document Server

    Martina, Maurizio

    2009-01-01

    This work proposes a general framework for the design and simulation of network on chip based turbo decoder architectures. Several parameters in the design space are investigated, namely the network topology, the parallelism degree, the rate at which messages are sent by processing nodes over the network and the routing strategy. The main results of this analysis are: i) the most suited topologies to achieve high throughput with a limited complexity overhead are generalized de-Bruijn and generalized Kautz topologies; ii) depending on the throughput requirements different parallelism degrees, message injection rates and routing algorithms can be used to minimize the network area overhead.

  11. A Novel Magnetic Bead-based Biosensor Using Flip Chip Bonding Techniques

    Institute of Scientific and Technical Information of China (English)

    Bin Wang; Xiang Chen; Qinghui Jin; Jianlong Zhao; Yuansen Xu

    2006-01-01

    Based on flip-chip packaging, a novel approach towards integrated magnetic bio-separator was designed. The magnetic field and the force on the bead were simulated and analyzed, leading to the optimization of the fabrication parameters of the micro-magnetic unit. The planar coil as an electromagnet was fabricated through electroplating on a single seed layer.The PDMS microfluidic channel was bonded on the inverse side after Si etching. The results presented in this paper provide a novel design and fabrication to approach a microfluidic bio-separation system with magnetic beads.

  12. Rapid identification of Yersinia pestis and Brucella melitensis by chip-based continuous flow PCR

    Science.gov (United States)

    Dietzsch, Michael; Hlawatsch, Nadine; Melzer, Falk; Tomaso, Herbert; Gärtner, Claudia; Neubauer, Heinrich

    2012-06-01

    To combat the threat of biological agents like Yersinia pestis and Brucella melitensis in bioterroristic scenarios requires fast, easy-to-use and safe identification systems. In this study we describe a system for rapid amplification of specific genetic markers for the identification of Yersinia pestis and Brucella melitensis. Using chip based PCR and continuous flow technology we were able to amplify the targets simultaneously with a 2-step reaction profile within 20 minutes. The subsequent analysis of amplified fragments by standard gel electrophoresis requires another 45 minutes. We were able to detect both pathogens within 75 minutes being much faster than most other nucleic acid amplification technologies.

  13. Fabrication of thermoplastics chips through lamination based techniques.

    Science.gov (United States)

    Miserere, Sandrine; Mottet, Guillaume; Taniga, Velan; Descroix, Stephanie; Viovy, Jean-Louis; Malaquin, Laurent

    2012-04-24

    In this work, we propose a novel strategy for the fabrication of flexible thermoplastic microdevices entirely based on lamination processes. The same low-cost laminator apparatus can be used from master fabrication to microchannel sealing. This process is appropriate for rapid prototyping at laboratory scale, but it can also be easily upscaled to industrial manufacturing. For demonstration, we used here Cycloolefin Copolymer (COC), a thermoplastic polymer that is extensively used for microfluidic applications. COC is a thermoplastic polymer with good chemical resistance to common chemicals used in microfluidics such as acids, bases and most polar solvents. Its optical quality and mechanical resistance make this material suitable for a large range of applications in chemistry or biology. As an example, the electrokinetic separation of pollutants is proposed in the present study.

  14. From bioseparation to artificial micro-organs: microfluidic chip based particle manipulation techniques

    Science.gov (United States)

    Stelzle, Martin

    2010-02-01

    Microfluidic device technology provides unique physical phenomena which are not available in the macroscopic world. These may be exploited towards a diverse array of applications in biotechnology and biomedicine ranging from bioseparation of particulate samples to the assembly of cells into structures that resemble the smallest functional unit of an organ. In this paper a general overview of chip-based particle manipulation and separation is given. In the state of the art electric, magnetic, optical and gravitational field effects are utilized. Also, mechanical obstacles often in combination with force fields and laminar flow are employed to achieve separation of particles or molecules. In addition, three applications based on dielectrophoretic forces for particle manipulation in microfluidic systems are discussed in more detail. Firstly, a virus assay is demonstrated. There, antibody-loaded microbeads are used to bind virus particles from a sample and subsequently are accumulated to form a pico-liter sized aggregate located at a predefined position in the chip thus enabling highly sensitive fluorescence detection. Secondly, subcellular fractionation of mitochondria from cell homogenate yields pure samples as was demonstrated by Western Blot and 2D PAGE analysis. Robust long-term operation with complex cell homogenate samples while avoiding electrode fouling is achieved by a set of dedicated technical means. Finally, a chip intended for the dielectrophoretic assembly of hepatocytes and endothelial cells into a structure resembling a liver sinusoid is presented. Such "artificial micro organs" are envisioned as substance screening test systems providing significantly higher predictability with respect to the in vivo response towards a substance under test.

  15. A Fully On-Chip Gm-Opamp-RC Based Preamplifier for Electret Condenser Microphones

    Science.gov (United States)

    Le, Huy-Binh; Ryu, Seung-Tak; Lee, Sang-Gug

    An on-chip CMOS preamplifier for direct signal readout from an electret capacitor microphone has been designed with high immunity to common-mode and supply noise. The Gm-Opamp-RC based high impedance preamplifier helps to remove all disadvantages of the conventional JFET based amplifier and can drive a following switched-capacitor sigma-delta modulator in order to realize a compact digital electret microphone. The proposed chip is designed based on 0.18µm CMOS technology, and the simulation results show 86dB of dynamic range with 4.5µVrms of input-referred noise for an audio bandwidth of 20kHz and a total harmonic distortion (THD) of 1% at 90mVrms input. Power supply rejection ratio (PSRR) and common-mode rejection ration (CMRR) are more than 95dB at 1kHz. The proposed design dissipates 125µA and can operate over a wide supply voltage range of 1.6V to 3.3V.

  16. On-chip magnetic bead-based DNA melting curve analysis using a magnetoresistive sensor

    Energy Technology Data Exchange (ETDEWEB)

    Rizzi, Giovanni, E-mail: giori@nanotech.dtu.dk; Østerberg, Frederik W.; Henriksen, Anders D.; Dufva, Martin; Hansen, Mikkel F., E-mail: mikkel.hansen@nanotech.dtu.dk

    2015-04-15

    We present real-time measurements of DNA melting curves in a chip-based system that detects the amount of surface-bound magnetic beads using magnetoresistive magnetic field sensors. The sensors detect the difference between the amount of beads bound to the top and bottom sensor branches of the differential sensor geometry. The sensor surfaces are functionalized with wild type (WT) and mutant type (MT) capture probes, differing by a single base insertion (a single nucleotide polymorphism, SNP). Complementary biotinylated targets in suspension couple streptavidin magnetic beads to the sensor surface. The beads are magnetized by the field arising from the bias current passed through the sensors. We demonstrate the first on-chip measurements of the melting of DNA hybrids upon a ramping of the temperature. This overcomes the limitation of using a single washing condition at constant temperature. Moreover, we demonstrate that a single sensor bridge can be used to genotype a SNP. - Highlights: • We apply magnetoresistive sensors to study solid-surface hybridization kinetics of DNA. • We measure DNA melting profiles for perfectly matching DNA duplexes and for a single base mismatch. • We present a procedure to correct for temperature dependencies of the sensor output. • We reliably extract melting temperatures for the DNA hybrids. • We demonstrate direct measurement of differential binding signal for two probes on a single sensor.

  17. A brief review on mixed convection heat transfer in channel flow with vortex generator for electronic chip cooling

    Directory of Open Access Journals (Sweden)

    S K Mandal

    2016-06-01

    Full Text Available In an effort to increase processor speeds, 3D IC architecture is being aggressively pursued by researchers and chip manufacturers. This architecture allows extremely high level of integration with enhanced electrical performance and expanded functionality, and facilitates realization of VLSI and ULSI technologies. However, utilizing the third dimension to provide additional device layers poses thermal challenges due to the increased heat dissipation and complex electrical interconnects among different layers. The conflicting needs of the cooling system requiring larger flow passage dimensions to limit the pressure drop, and the IC architecture necessitating short interconnect distances to reduce signal latency warrant paradigm shifts in both of their design approach. Additional considerations include the effects due to temperature non-uniformity, localized hot spots, complex fluidic connections, and mechanical design. This paper reviews the advances in electronic chip cooling in the last decade and provides a vision for code signing integrated cooling systems. For various heat fluxes on each side of a chip acting as discrete heat source, the current single-phase cooling technology is projected to provide adequate cooling, albeit with high pressure drops. Effectively mitigating the high temperatures surrounding local hot spots remains a challenging issue. Various forms of tabulators above the chips, different geometric arrangements of the chips positioned top and bottom wall of the duct serves very well in the heat augmentation technique with better performance

  18. MEGen: A Physiologically Based Pharmacokinetic Model Generator

    Directory of Open Access Journals (Sweden)

    George D Loizou

    2011-11-01

    Full Text Available Physiologically based pharmacokinetic models are being used in an increasing number of different areas. These not only include the human safety assessment of pharmaceuticals, pesticides, biocides and environmental chemicals but also for food animal, wild mammal and avian risk assessment. The value of PBPK models is that they are tools for estimating tissue dosimetry by integrating in vitro and in vivo mechanistic, pharmacokinetic and toxicological information through their explicit mathematical description of important anatomical, physiological and biochemical determinants of chemical uptake, disposition and elimination. However, PBPK models are perceived as complex, data hungry, resource intensive and time consuming. In addition, model validation and verification are hindered by the relative complexity of the equations. To begin to address these issues a freely available web application for the rapid construction and documentation of bespoke PBPK models is under development. Here we present an overview of the current capabilities of MEGen, a model equation generator and parameter database and discuss future developments.

  19. High resistivity iron-based, thermally stable magnetic material for on-chip integrated inductors

    Energy Technology Data Exchange (ETDEWEB)

    Deligianni, Hariklia; Gallagher, William J.; Mason, Maurice; O' Sullivan, Eugene J.; Romankiw, Lubomyr T.; Wang, Naigang

    2017-03-07

    An on-chip magnetic structure includes a palladium activated seed layer and a substantially amorphous magnetic material disposed onto the palladium activated seed layer. The substantially amorphous magnetic material includes nickel in a range from about 50 to about 80 atomic % (at. %) based on the total number of atoms of the magnetic material, iron in a range from about 10 to about 50 at. % based on the total number of atoms of the magnetic material, and phosphorous in a range from about 0.1 to about 30 at. % based on the total number of atoms of the magnetic material. The magnetic material can include boron in a range from about 0.1 to about 5 at. % based on the total number of atoms of the magnetic material.

  20. Recent advances in particle and droplet manipulation for lab-on-a-chip devices based on surface acoustic waves.

    Science.gov (United States)

    Wang, Zhuochen; Zhe, Jiang

    2011-04-07

    Manipulation of microscale particles and fluid liquid droplets is an important task for lab-on-a-chip devices for numerous biological researches and applications, such as cell detection and tissue engineering. Particle manipulation techniques based on surface acoustic waves (SAWs) appear effective for lab-on-a-chip devices because they are non-invasive, compatible with soft lithography micromachining, have high energy density, and work for nearly any type of microscale particles. Here we review the most recent research and development of the past two years in SAW based particle and liquid droplet manipulation for lab-on-a-chip devices including particle focusing and separation, particle alignment and patterning, particle directing, and liquid droplet delivery.

  1. Paper-Based Digital Microfluidic Chip for Multiple Electrochemical Assay Operated by a Wireless Portable Control System

    DEFF Research Database (Denmark)

    Ruecha, Nipapan; Lee, Jumi; Chae, Heedo

    2017-01-01

    The printing and modular fabrication of a paper-based active microfluidic lab on a chip implemented with electrochemical sensors (ECSs) is developed and integrated on a portable electrical control system. The electrodes of a chip plate for active electrowetting actuation of digital drops and an ECS...... for multiple analysis assays are fabricated by affordable printing techniques. For enhanced sensitivity of the sensor, the working electrode is modified through the electrochemical method, namely by reducing graphene with voltammetry and coating gold nanoparticles by amperometry. Detachable sensor and absorber...... designed portable power supply and wireless control system, the active paper-based chip platform can be utilized as an advanced point-of-care device for multiple assays in digital microfluidics....

  2. Delivery of molecules into cells using localized single cell electroporation on ITO micro-electrode based transparent chip.

    Science.gov (United States)

    Chen, Sheng-Chiech; Santra, Tuhin Subhra; Chang, Chia-Jung; Chen, Tsung-Ju; Wang, Pen-Cheng; Tseng, Fan-Gang

    2012-10-01

    Single cell electroporation is one of the nonviral method which successfully allows transfection of exogenous macromolecules into individual living cell. We present localized cell membrane electroporation at single-cell level by using indium tin oxide (ITO) based transparent micro-electrodes chip with inverted microscope. A focused ion beam (FIB) technique has been successfully deployed to fabricate transparent ITO micro-electrodes with submicron gaps, which can generate more intense electric field to produce very localized cell membrane electroporation. In our approach, we have successfully achieved 0.93 μm or smaller electroporation region on the cell surface to inject PI (Propidium Iodide) dye into the cell with 60 % cell viability. This experiments successfully demonstrate the cell self-recover process from the injected PI dye intensity variation. Our localized cell membrane electroporation technique (LSCMEP) not only generates reversible electroporation process but also it provides a clear optical path for potentially monitoring/tracking of drugs to deliver in single cell level.

  3. Integrated chip-based physiometer for automated fish embryo toxicity biotests in pharmaceutical screening and ecotoxicology.

    Science.gov (United States)

    Akagi, Jin; Zhu, Feng; Hall, Chris J; Crosier, Kathryn E; Crosier, Philip S; Wlodkowic, Donald

    2014-06-01

    Transgenic zebrafish (Danio rerio) models of human diseases have recently emerged as innovative experimental systems in drug discovery and molecular pathology. None of the currently available technologies, however, allow for automated immobilization and treatment of large numbers of spatially encoded transgenic embryos during real-time developmental analysis. This work describes the proof-of-concept design and validation of an integrated 3D microfluidic chip-based system fabricated directly in the poly(methyl methacrylate) transparent thermoplastic using infrared laser micromachining. At its core, the device utilizes an array of 3D micromechanical traps to actively capture and immobilize single embryos using a low-pressure suction. It also features built-in piezoelectric microdiaphragm pumps, embryo-trapping suction manifold, drug delivery manifold, and optically transparent indium tin oxide heating element to provide optimal temperature during embryo development. Furthermore, we present design of the proof-of-concept off-chip electronic interface equipped with robotic servo actuator driven stage, innovative servomotor-actuated pinch valves, and embedded miniaturized fluorescent USB microscope. Our results showed that the innovative device has 100% embryo-trapping efficiency while supporting normal embryo development for up to 72 hr in a confined microfluidic environment. We also showed data that this microfluidic system can be readily applied to kinetic analysis of a panel of investigational antiangiogenic agents in transgenic zebrafish lines. The optical transparency and embryo immobilization allow for convenient visualization of developing vasculature patterns in response to drug treatment without the need for specimen re-positioning. The integrated electronic interfaces bring the lab-on-a-chip systems a step closer to realization of complete analytical automation.

  4. Chip Implementation with a Combined Wireless Temperature Sensor and Reference Devices Based on the DZTC Principle

    Directory of Open Access Journals (Sweden)

    Shey-Shi Lu

    2011-10-01

    Full Text Available This paper presents a novel CMOS wireless temperature sensor design in order to improve the sensitivity and linearity of our previous work on such devices. Based on the principle of CMOS double zero temperature coefficient (DZTC points, a combined device is first created at the chip level with two voltage references, one current reference, and one temperature sensor. It was successfully fabricated using the 0.35 μm CMOS process. According to the chip results in a wide temperature range from −20 °C to 120 °C, two voltage references can provide temperature-stable outputs of 823 mV and 1,265 mV with maximum deviations of 0.2 mV and 8.9 mV, respectively. The result for the current reference gives a measurement of 23.5 µA, with a maximum deviation of 1.2 µA. The measurements also show that the wireless temperature sensor has good sensitivity of 9.55 mV/°C and high linearity of 97%. The proposed temperature sensor has 4.15-times better sensitivity than the previous design. Moreover, to facilitate temperature data collection, standard wireless data transmission is chosen; therefore, an 8-bit successive-approximation-register (SAR analog-to-digital converter (ADC and a 433 MHz wireless transmitter are also integrated in this chip. Sensing data from different places can be collected remotely avoiding the need for complex wire lines.

  5. A rainfall simulator based on multifractal generator

    Science.gov (United States)

    Akrour, Nawal; mallet, Cecile; barthes, Laurent; chazottes, Aymeric

    2015-04-01

    The Precipitations are due to complex meteorological phenomenon's and unlike other geophysical constituents such as water vapour concentration they present a relaxation behaviour leading to an alternation of dry and wet periods. Thus, precipitations can be described as intermittent process. The spatial and temporal variability of this phenomenon is significant and covers large scales. This high variability can cause extreme events which are difficult to observe properly because of their suddenness and their localized character. For all these reasons, the precipitations are therefore difficult to model. This study aims to adapt a one-dimensional time series model previously developed by the authors [Akrour et al., 2013, 2014] to a two-dimensional rainfall generator. The original time series model can be divided into 3 major steps : rain support generation, intra event rain rates generation using multifractal and finally calibration process. We use the same kind of methodology in the present study. Based on dataset obtained from meteorological radar of Météo France with a spatial resolution of 1 km x 1 km we present the used approach : Firstly, the extraction of rain support (rain/no rain area) allowing the retrieval of the rain support structure function (variogram) and fractal properties. This leads us to use either the rain support modelisation proposed by ScleissXXX [ref] or directly real rain support extracted from radar rain maps. Then, the generation (over rain areas) of rain rates is made thanks to a 2D multifractal Fractionnally Integrated Flux (FIF) model [ref]. This second stage is followed by a calibration/forcing step (forcing average rain rate per events) added in order to provide rain rate coherent with observed rain-rate distribution. The forcing process is based on a relation identified from the average rain rate of observed events and their surfaces. The presentation will first explain the different steps presented above, then some results

  6. One-chip electronic detection of DNA hybridization using precision impedance-based CMOS array sensor.

    Science.gov (United States)

    Lee, Kang-Ho; Lee, Jeong-Oen; Sohn, Mi-Jin; Lee, Byunghun; Choi, Suk-Hwan; Kim, Sang Kyu; Yoon, Jun-Bo; Cho, Gyu-Hyeong

    2010-12-15

    This paper describes a label-free and fully electronic detection method of DNA hybridization, which is achieved through the use of a 16×8 microarray sensor in conjunction with a new type of impedance spectroscopy constructed with standard complementary metal-oxide-semiconductor (CMOS) technology. The impedance-based method is based on changes in the reactive capacitance and the charge-transfer resistance after hybridization with complementary DNA targets. In previously published label-free techniques, the measured capacitance presented unstable capacitive properties due to the parallel resistance that is not infinite and can cause a leakage by discharging the charge on the capacitor. This paper presents an impedance extraction method that uses excitation by triangular wave voltage, which enables a reliable measurement of both C and R producing a highly sensitive sensor with a stable operation independent of external variables. The system was fabricated in an industrial 0.35-μm 4-metal 2-poly CMOS process, integrating working electrodes and readout electronics into one chip. The integrated readout, which uses a parasitic insensitive integrator, achieves an enlarged detection range and improved noise performance. The maximum average relative variations of C and R are 31.5% and 68.6%, respectively, after hybridization with a 1 μM target DNA. The proposed sensor allows quantitative evaluation of the molecule densities on the chip with distinguishable variation in the impedance. This fully electronic microsystem has great potential for use with bioanalytical tools and point-of-care diagnosis.

  7. SAD-based stereo vision machine on a System-on-Programmable-Chip (SoPC).

    Science.gov (United States)

    Zhang, Xiang; Chen, Zhangwei

    2013-03-04

    This paper, proposes a novel solution for a stereo vision machine based on the System-on-Programmable-Chip (SoPC) architecture. The SOPC technology provides great convenience for accessing many hardware devices such as DDRII, SSRAM, Flash, etc., by IP reuse. The system hardware is implemented in a single FPGA chip involving a 32-bit Nios II microprocessor, which is a configurable soft IP core in charge of managing the image buffer and users' configuration data. The Sum of Absolute Differences (SAD) algorithm is used for dense disparity map computation. The circuits of the algorithmic module are modeled by the Matlab-based DSP Builder. With a set of configuration interfaces, the machine can process many different sizes of stereo pair images. The maximum image size is up to 512 K pixels. This machine is designed to focus on real time stereo vision applications. The stereo vision machine offers good performance and high efficiency in real time. Considering a hardware FPGA clock of 90 MHz, 23 frames of 640 × 480 disparity maps can be obtained in one second with 5 × 5 matching window and maximum 64 disparity pixels.

  8. SAD-Based Stereo Vision Machine on a System-on-Programmable-Chip (SoPC

    Directory of Open Access Journals (Sweden)

    Zhangwei Chen

    2013-03-01

    Full Text Available This paper, proposes a novel solution for a stereo vision machine based on the System-on-Programmable-Chip (SoPC architecture. The SOPC technology provides great convenience for accessing many hardware devices such as DDRII, SSRAM, Flash, etc., by IP reuse. The system hardware is implemented in a single FPGA chip involving a 32-bit Nios II microprocessor, which is a configurable soft IP core in charge of managing the image buffer and users’ configuration data. The Sum of Absolute Differences (SAD algorithm is used for dense disparity map computation. The circuits of the algorithmic module are modeled by the Matlab-based DSP Builder. With a set of configuration interfaces, the machine can process many different sizes of stereo pair images. The maximum image size is up to 512 K pixels. This machine is designed to focus on real time stereo vision applications. The stereo vision machine offers good performance and high efficiency in real time. Considering a hardware FPGA clock of 90 MHz, 23 frames of 640 × 480 disparity maps can be obtained in one second with 5 × 5 matching window and maximum 64 disparity pixels.

  9. Magnetic Tunnel Junction-Based On-Chip Microwave Phase and Spectrum Analyzer

    Science.gov (United States)

    Fan, Xin; Chen, Yunpeng; Xie, Yunsong; Kolodzey, James; Wilson, Jeffrey D.; Simons, Rainee N.; Xiao, John Q.

    2014-01-01

    A magnetic tunnel junction (MTJ)-based microwave detector is proposed and investigated. When the MTJ is excited by microwave magnetic fields, the relative angle between the free layer and pinned layer alternates, giving rise to an average resistance change. By measuring the average resistance change, the MTJ can be utilized as a microwave power sensor. Due to the nature of ferromagnetic resonance, the frequency of an incident microwave is directly determined. In addition, by integrating a mixer circuit, the MTJ-based microwave detector can also determine the relative phase between two microwave signals. Thus, the MTJ-based microwave detector can be used as an on-chip microwave phase and spectrum analyzer.

  10. Nanoneedles based on porous silicon for chip bonding with self assembly capability

    Energy Technology Data Exchange (ETDEWEB)

    Jonnalagadda, Prasad; Mescheder, Ulrich; Kovacs, Andras; Nimoe, Antwi [Institute for Applied Research and Faculty Computer and Electrical Engineering, Hochschule Furtwangen University, Robert-Gerwig-Platz 1, 78120 Furtwangen (Germany)

    2011-06-15

    Needle-like surface structures have been fabricated using a self-organized nanostructuring process based on porous silicon. Optimized surfaces have been used for a novel bonding process in Si-MEMS. The realized needle-like surfaces enable Van-der-Waals based bonding at low temperature with self-assembly capability. The bonding forces depend on the surface topology and can be tailored by the nanostructuring process between permanent and detachable bonding. Bond strength for permanent bonding in the range of 1-10 MPa has been achieved. Multiple bonding of the same surface is possible (Velcro {sup registered} -principle). The capability of needle like surfaces for self aligned bonding of Si-chips or small silicon based systems (''smart dust'') on locally nanostructured areas of silicon wafers (Si-motherboard) has been shown. (copyright 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  11. An Integrated Microfabricated Chip with Double Functions as an Ion Source and Air Pump Based on LIGA Technology

    Directory of Open Access Journals (Sweden)

    Hua Li

    2017-01-01

    Full Text Available The injection and ionization of volatile organic compounds (VOA by an integrated chip is experimentally analyzed in this paper. The integrated chip consists of a needle-to-cylinder electrode mounting on the Polymethyl Methacrylate (PMMA substrate. The needle-to-cylinder electrode is designed and fabricated by Lithographie, Galvanoformung and Abformung (LIGA technology. In this paper, the needle is connected to a negative power supply of −5 kV and used as the cathode; the cylinder electrodes are composed of two arrays of cylinders and serve as the anode. The ionic wind is produced based on corona and glow discharges of needle-to-cylinder electrodes. The experimental setup is designed to observe the properties of the needle-to-cylinder discharge and prove its functions as an ion source and air pump. In summary, the main results are as follows: (1 the ionic wind velocity produced by the chip is about 0.79 m/s at an applied voltage of −3300 V; (2 acetic acid and ammonia water can be injected through the chip, which is proved by pH test paper; and (3 the current measured by a Faraday cup is about 10 pA for acetic acid and ammonia with an applied voltage of −3185 V. The integrated chip is promising for portable analytical instruments, such as ion mobility spectrometry (IMS, field asymmetric ion mobility spectrometry (FAIMS, and mass spectrometry (MS.

  12. Microfluidic geometric metering-based multi-reagent mixture generator for robust live cell screening array.

    Science.gov (United States)

    Wang, Han; Kim, Jeongyun; Jayaraman, Arul; Han, Arum

    2014-12-01

    Microfluidic live cell arrays with integrated concentration gradient or mixture generators have been utilized in screening cellular responses to various biomolecular cues. Microfluidic network-based gradient generators that can create concentration gradients by repeatedly splitting and mixing different solutions using networks of serpentine channels are commonly used. However, in this method the generation of concentration gradients relies on the continuous flow of sample solutions at optimized flow rates, which poses challenges in maintaining the pressure and flow stability throughout the entire assay period. Here we present a microfluidic live cell screening array with an on-demand multi-reagent mixture generator where the mixing ratios, thus generated concentrations, are hard-wired into the chip itself through a geometric metering method. This platform showed significantly improved robustness and repeatability in generating concentration gradients of fluorescent dyes (average coefficient of variance C.V. = 9 %) compared to the conventional network-based gradient generators (average C.V. = 21 %). In studying the concentration dependent effects of the environmental toxicant 3-methylcholanthrene (3MC) on the activation of cytochrome P450 1A1 (Cyp 1A1) enzyme in H4IIE rat hepatoma cells, statistical variation of the Cyp 1A1 response was significantly lower (C.V. = 5 %) when using the developed mixture generator compared to that using the conventional gradient generator (C.V. = 12 %). Reduction in reagent consumption by 12-times was also achieved. This robust, accurate, and scalable multi-reagent mixture generator integrated with a cell culture array as a live cell assay platform can be readily implemented into various screening applications where repeatability, robustness, and low reagent consumptions over long periods of assay time are of importance.

  13. Surface Roughness Study on Microchannels of CO2 Laser Fabricating Pmma-Based Microfluidic Chip

    Science.gov (United States)

    Chen, Xueye; Li, Tiechuan; Fu, Baoding

    A novel method named soak sacrificial layer ultrasonic method (SSLUM) has been presented for optimizing the surface roughness of the microchannels of polymethyl methacrylate (PMMA)-based microfluidic chips. CO2 laser was used for ablative microchannels on the PMMA sheet, and the effects of key parameters including laser power, laser ablation speed and solution concentration on the surface roughness of microchannels were estimated and optimized by SSLUM. The experimental observation demonstrates that the surface roughness results mainly from the residues on the channel wall, which are produced by the bubbles movement and bursting. The research results show that the surface roughness can be improved effectively by using SSLUM. In our experiment, the best value was Ra = 110nm with laser power 12W, laser ablation speed 10mm/s, the solution concentration 75%, and the time of ultrasonic vibration 25min. SSLUM is proven to be an effective, simple and rapid method for optimizing the surface roughness of microchannels of microfluidic chips.

  14. Low power, chip-based stimulated Brillouin scattering microwave photonic filter with ultrahigh selectivity

    CERN Document Server

    Marpaung, David; Pagani, Mattia; Pant, Ravi; Choi, Duk-Yong; Luther-Davies, Barry; Madden, Steve J; Eggleton, Benjamin J

    2014-01-01

    Highly selective and reconfigurable microwave filters are of great importance in radio-frequency signal processing. Microwave photonic (MWP) filters are of particular interest, as they offer flexible reconfiguration and an order of magnitude higher frequency tuning range than electronic filters. However, all MWP filters to date have been limited by trade-offs between key parameters such as tuning range, resolution, and suppression. This problem is exacerbated in the case of integrated MWP filters, blocking the path to compact, high performance filters. Here we show the first chip-based MWP band-stop filter with ultra-high suppression, high resolution in the MHz range, and 0-30 GHz frequency tuning. This record performance was achieved using an ultra-low Brillouin gain from a compact photonic chip and a novel approach of optical resonance-assisted RF signal cancellation. The results point to new ways of creating energy-efficient and reconfigurable integrated MWP signal processors for wireless communications an...

  15. Investigation of high extraction efficiency flip-chip GaN-based light-emitting diodes

    Institute of Scientific and Technical Information of China (English)

    DA XiaoLi; SHEN GuangDi; XU Chen; ZOU DeShu; ZHU YanXu; ZHANG JianMing

    2009-01-01

    In order to obtain higher light output power, the flip-chip structure Is used. We studied the ratio of the light of GaN sides before and after fabricating metal reflector on p-GaN. The SiO2/SiNx dielectric film reflectors were deposited through plasma enhance chemical vapor deposition following the fabrication of metal reflector, and then the dielectric film reflectors on the electrodes were etched in order to expose the electrodes to the air. It is found that comparing with the flip-chip GaN-LED without dielectric film reflectors, light output power can be increased by as high as 10.2% after the deposition of 2 pairs of SiO2/SiNx dielectric film reflectors on GaN-LEDs, which cover the sidewalls and the areas without the metal reflector. This result indicates that the high reflector formed by multi-layer dielectric films is useful to enhance the light output power of GaN-based LED, which reflects light from step sidewalls and p-GaN without metal reflector to internal, and then light emits from the surface.

  16. Electrochemical chip-based genomagnetic assay for detection of high-risk human papillomavirus DNA.

    Science.gov (United States)

    Bartosik, Martin; Durikova, Helena; Vojtesek, Borivoj; Anton, Milan; Jandakova, Eva; Hrstka, Roman

    2016-09-15

    Cervical cancer, being the fourth leading cause of cancer death in women worldwide, predominantly originates from a persistent infection with a high-risk human papillomavirus (HPV). Detection of DNA sequences from these high-risk strains, mostly HPV-16 and HPV-18, represents promising strategy for early screening, which would help to identify women with higher risk of cervical cancer. In developing countries, inadequate screening options lead to disproportionately high mortality rates, making a fast and inexpensive detection schemes highly important. Electrochemical sensors and assays offer an alternative to current methods of detection. We developed an electrochemical-chip based assay, in which target HPV DNA is captured via magnetic bead-modified DNA probes, followed by an antidigoxigenin-peroxidase detection system at screen-printed carbon electrode chips, enabling parallel measurements of eight samples simultaneously. We show sensitive detection in attomoles of HPV DNA, selective discrimination between HPV-16 and HPV-18 and good reproducibility. Most importantly, we show application of the assay into both cancer cell lines and cervical smears from patients. The electrochemical results correlated well with standard methods, making this assay potentially applicable in clinical practice.

  17. Plastic-Chip-Based Magnetophoretic Immunoassay for Point-of-Care Diagnosis of Tuberculosis.

    Science.gov (United States)

    Kim, Jeonghyo; Jang, Minji; Lee, Kyoung G; Lee, Kil-Soo; Lee, Seok Jae; Ro, Kyung-Won; Kang, In Sung; Jeong, Byung Do; Park, Tae Jung; Kim, Hwa-Jung; Lee, Jaebeom

    2016-09-14

    Tuberculosis (TB) remains a relevant infectious disease in the 21st century, and its extermination is still far from being attained. Due to the extreme infectivity of incipient TB patients, a rapid sensing system for proficient point-of-care (POC) diagnostics is required. In our study, a plastic-chip-based magnetophoretic immunoassay (pcMPI) is introduced using magnetic and gold nanoparticles (NPs) modified with Mycobacterium tuberculosis (MTB) antibodies. This pcMPI offers an ultrasensitive limit of detection (LOD) of 1.8 pg·ml(-1) for the detection of CFP-10, an MTB-secreted antigen, as a potential TB biomarker with high specificity. In addition, by combining the plastic chip with an automated spectrophotometer setup, advantages include ease of operation, rapid time to results (1 h), and cost-effectiveness. Furthermore, the pcMPI results using clinical sputum culture filtrate samples are competitively compared with and integrated with clinical data collected from conventional tools such as the acid-fast bacilli (AFB) test, mycobacteria growth indicator tube (MGIT), polymerase chain reaction (PCR), and physiological results. CFP-10 concentrations were consistently higher in patients diagnosed with MTB infection than those seen in patients infected with nontuberculosis mycobacteria (NTM) (P < 0.05), and this novel test can distinguish MTB and NTM while MGIT cannot. All these results indicate that this pcMPI has the potential to become a new commercial TB diagnostic POC platform in view of its sensitivity, portability, and affordability.

  18. On-chip two-mode division multiplexing using tapered directional coupler-based mode multiplexer and demultiplexer

    DEFF Research Database (Denmark)

    Ding, Yunhong; Xu, Jing; Da Ros, Francesco;

    2013-01-01

    Abstract: We demonstrate a novel on-chip two-mode division multiplexing circuit using a tapered directional coupler-based TE0&TE1 mode multiplexer and demultiplexer on the silicon-on-insulator platform. A low insertion loss (0.3 dB), low mode crosstalk (...), and large fabrication tolerance (20 nm) are measured. An on-chip mode multiplexing experiment is carried out on the fabricated circuit with non return-to-zero (NRZ) on-off keying (OOK) signals at 40 Gbit/s. The experimental results show clear eye diagrams and moderate power penalty for both TE0 and TE1...... modes....

  19. Chip Multithreaded Consistency Model

    Institute of Scientific and Technical Information of China (English)

    Zu-Song Li; Dan-Dan Huan; Wei-Wu Hu; Zhi-Min Tang

    2008-01-01

    Multithreaded technique is the developing trend of high performance processor. Memory consistency model is essential to the correctness, performance and complexity of multithreaded processor. The chip multithreaded consistency model adapting to multithreaded processor is proposed in this paper. The restriction imposed on memory event ordering by chip multithreaded consistency is presented and formalized. With the idea of critical cycle built by Wei-Wu Hu, we prove that the proposed chip multithreaded consistency model satisfies the criterion of correct execution of sequential consistency model. Chip multithreaded consistency model provides a way of achieving high performance compared with sequential consistency model and ensures the compatibility of software that the execution result in multithreaded processor is the same as the execution result in uniprocessor. The implementation strategy of chip multithreaded consistency model in Godson-2 SMT processor is also proposed. Godson-2 SMT processor supports chip multithreaded consistency model correctly by exception scheme based on the sequential memory access queue of each thread.

  20. On-Chip Scan-Based Test Strategy for a Dependable Many-Core Processor Using a NoC as a Test Access Mechanism

    NARCIS (Netherlands)

    Zhang, Xiao; Kerkhoff, Hans G.; Vermeulen, Bart

    2010-01-01

    Periodic on-chip scan-based tests have to be applied to a many-core processor SoC to improve its dependability. An infrastructural IP module has been designed and incorporated into the SoC to function as an ATE. This paper introduces the reuse of a Network-on-Chip as a test access mechanism. Since t

  1. UW VLSI chip tester

    Science.gov (United States)

    McKenzie, Neil

    1989-12-01

    We present a design for a low-cost, functional VLSI chip tester. It is based on the Apple MacIntosh II personal computer. It tests chips that have up to 128 pins. All pin drivers of the tester are bidirectional; each pin is programmed independently as an input or an output. The tester can test both static and dynamic chips. Rudimentary speed testing is provided. Chips are tested by executing C programs written by the user. A software library is provided for program development. Tests run under both the Mac Operating System and A/UX. The design is implemented using Xilinx Logic Cell Arrays. Price/performance tradeoffs are discussed.

  2. Analysis of on-chip distributed interconnects based on Pade expansion

    Institute of Scientific and Technical Information of China (English)

    Xiaopeng JI; Long GE; Zhiquan WANG

    2009-01-01

    In this paper,on-chip interconnects are modeled as distributed parameter RLCG transmission lines,based on which the matrix ABCD of interconnects is deduced.With help of the ABCD matrix,a voltage transfer function of an interconnect system,consisting of a driver,interconnect line and load,is obtained analytically in the form of a transcen-dental function,and it is reduced to a finite order system based on high order Pade approximation.With the reduced-order transfer function,response waveforms with step input can be obtained,and signal delay can be calculated consequently.Two numerical experiments are conducted to demonstrate its efficiency.

  3. Optimizing design of triplexer chip with low insert loss and high isolation based on planar lightwave circuit

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Design optimization of a novel integrated triplexer based on planar lightwave circuit (PLC) for fiber-to-the-home applications is described. The two-mode interference coupler and Mach-Zehnder interference are used to construct the filter chip.Simulation results of high isolation and low insertion loss are gotten for proposed design. Technique tolerance is improved for fabricating device.

  4. Paper-based chromatographic chemiluminescence chip for the detection of dichlorvos in vegetables.

    Science.gov (United States)

    Liu, Wei; Kou, Juan; Xing, Huizhong; Li, Baoxin

    2014-02-15

    Paper chromatography was a big breakthrough in the early of 20th century but it is rarely used due to the long separation time and the diffusion on the sample spots. In this work, for the first time, a paper-based chemiluminescence (CL) analytical device combined with paper chromatography was developed for the determination of dichlorvos (DDV) in vegetables without complicated sample pretreatment. The paper chromatography separation procedure can be accomplished in 12 min on a paper support (0.8 × 7.0 cm(2)) by using 5 µL sample spotted on it. After sample developing, the detection area (0.8 × 1.0 cm(2)) was cut and inserted between two layers of water-impermeable single-sided adhesive tapes. The paper-based chip was made by attaching the middle layer of paper onto the bottom layer. Then it was covered by another tape layer, which was patterned by the cutting method to form a square hole (0.8 × 1.0 cm(2)) in it. 10 μL mixed solution of luminol and H2O2 was dropped on the detection area to produce CL. A linear relationship was obtained between the CL intensity and the concentrations of DDV in the range between 10.0 ng mL(-1) and 1.0 μg mL(-1)and the detection limit was 3.6 ng mL(-1). Water-soluble metal ions and vitamins can be developed at different spatial locations relative to DDV, eliminating interference with DDV during detection. The paper-based chromatographic chip can be successfully used for the determination of DDV without complicated sample preparation in vegetables. This study should, therefore, be suitable for rapid and sensitive detection of trace levels of organophosphate pesticides in environmental and food samples.

  5. The System Power Control Unit Based on the On-Chip Wireless Communication System

    Directory of Open Access Journals (Sweden)

    Tiefeng Li

    2013-01-01

    Full Text Available Currently, the on-chip wireless communication system (OWCS includes 2nd-generation (2G, 3rd-generation (3G, and long-term evolution (LTE communication subsystems. To improve the power consumption of OWCS, a typical architecture design of system power control unit (SPCU is given in this paper, which can not only make a 2G, a 3G, and an LTE subsystems enter sleep mode, but it can also wake them up from sleep mode via the interrupt. During the sleep mode period, either the real-time sleep timer or the global system for mobile (GSM communication sleep timer can be used individually to arouse the corresponding subsystem. Compared to previous sole voltage supplies on the OWCS, a 2G, a 3G, or an LTE subsystem can be independently configured with three different voltages and frequencies in normal work mode. In the meantime, the voltage supply monitor, which is an important part in the SPCU, can significantly guard the voltage of OWCS in real time. Finally, the SPCU may implement dynamic voltage and frequency scaling (DVFS for a 2G, a 3G, or an LTE subsystem, which is automatically accomplished by the hardware.

  6. The system power control unit based on the on-chip wireless communication system.

    Science.gov (United States)

    Li, Tiefeng; Ma, Caiwen; Li, WenHua

    2013-01-01

    Currently, the on-chip wireless communication system (OWCS) includes 2nd-generation (2G), 3rd-generation (3G), and long-term evolution (LTE) communication subsystems. To improve the power consumption of OWCS, a typical architecture design of system power control unit (SPCU) is given in this paper, which can not only make a 2G, a 3G, and an LTE subsystems enter sleep mode, but it can also wake them up from sleep mode via the interrupt. During the sleep mode period, either the real-time sleep timer or the global system for mobile (GSM) communication sleep timer can be used individually to arouse the corresponding subsystem. Compared to previous sole voltage supplies on the OWCS, a 2G, a 3G, or an LTE subsystem can be independently configured with three different voltages and frequencies in normal work mode. In the meantime, the voltage supply monitor, which is an important part in the SPCU, can significantly guard the voltage of OWCS in real time. Finally, the SPCU may implement dynamic voltage and frequency scaling (DVFS) for a 2G, a 3G, or an LTE subsystem, which is automatically accomplished by the hardware.

  7. The System Power Control Unit Based on the On-Chip Wireless Communication System

    Science.gov (United States)

    Li, Tiefeng; Ma, Caiwen; Li, WenHua

    2013-01-01

    Currently, the on-chip wireless communication system (OWCS) includes 2nd-generation (2G), 3rd-generation (3G), and long-term evolution (LTE) communication subsystems. To improve the power consumption of OWCS, a typical architecture design of system power control unit (SPCU) is given in this paper, which can not only make a 2G, a 3G, and an LTE subsystems enter sleep mode, but it can also wake them up from sleep mode via the interrupt. During the sleep mode period, either the real-time sleep timer or the global system for mobile (GSM) communication sleep timer can be used individually to arouse the corresponding subsystem. Compared to previous sole voltage supplies on the OWCS, a 2G, a 3G, or an LTE subsystem can be independently configured with three different voltages and frequencies in normal work mode. In the meantime, the voltage supply monitor, which is an important part in the SPCU, can significantly guard the voltage of OWCS in real time. Finally, the SPCU may implement dynamic voltage and frequency scaling (DVFS) for a 2G, a 3G, or an LTE subsystem, which is automatically accomplished by the hardware. PMID:23818835

  8. Keystream Generator Based On Simulated Annealing

    Directory of Open Access Journals (Sweden)

    Ayad A. Abdulsalam

    2011-01-01

    Full Text Available Advances in the design of keystream generator using heuristic techniques are reported. A simulated annealing algorithm for generating random keystream with large complexity is presented. Simulated annealing technique is adapted to locate these requirements. The definitions for some cryptographic properties are generalized, providing a measure suitable for use as an objective function in a simulated annealing algorithm, seeking randomness that satisfy both correlation immunity and the large linear complexity. Results are presented demonstrating the effectiveness of the method.

  9. A Smart Mobile Lab-on-Chip-Based Medical Diagnostics System Architecture Designed For Evolvability

    DEFF Research Database (Denmark)

    Patou, François; Dimaki, Maria; Svendsen, Winnie Edith

    2015-01-01

    Unprecedented knowledge levels in life sciences along with technological advances in micro- and nanotechnologies and microfluidics have recently conditioned the advent of Lab-on-Chip (LoC) devices for In-Vitro Medical Testing (IVMT). Combined with smart-mobile technologies, LoCs are pervasively...... giving rise to opportunities to better diagnose disease, predict and monitor personalised treatment efficacy, or provide healthcare decision-making support at the Point-of-Care (PoC). Although made increasingly available to the consumer market, the adoption of LoC-based PoC In-Vitro Medical Testing (IVMT......) systems is still in its infancy. This attrition partly pertains to the intricacy of designing and developing complex systems, destined to be used sporadically, in a fast-pace evolving technological paradigm. System evolvability is therefore key in the design process and constitutes the main motivation...

  10. Chip-integrated all-optical diode based on nonlinear plasmonic nanocavities covered with multicomponent nanocomposite

    Science.gov (United States)

    Chai, Zhen; Hu, Xiaoyong; Yang, Hong; Gong, Qihuang

    2017-01-01

    Ultracompact chip-integrated all-optical diode is realized experimentally in a plasmonic microstructure, consisting of a plasmonic waveguide side-coupled two asymmetric plasmonic composite nanocavities covered with a multicomponent nanocomposite layer, formed directly in a plasmonic circuit. Extremely large optical nonlinearity enhancement is obtained for the multicomponent nanocomposite cover layer, originating from resonant excitation, slow-light effect, and field enhancement effect. Nonreciprocal transmission was achieved based on the difference in the shift magnitude of the transparency window centers of two asymmetric plasmonic nanocavities induced by the signal light, itself, for the forward and backward propagation cases. An ultralow threshold incident light power of 145 μW (corresponding to a threshold intensity of 570 kW/cm2) is realized, which is reduced by seven orders of magnitude compared with previous reports. An ultrasmall feature size of 2 μm and a transmission contrast ratio of 15 dB are obtained simultaneously.

  11. Scheduling method based on virtual flattened architecture for Hierarchical system-on-chip

    Institute of Scientific and Technical Information of China (English)

    ZHANG Dong; ZHANG Jin-yi; YANG Xiao-dong; YANG Yi

    2009-01-01

    As the technology of IP-core-reused has been widely used, a lot of intellectual property (IP) cores have been embedded in different layers of system-on-chip (SOC). Although the cycles of development and overhead are reduced by this method, it is a challenge to the SOC test. This paper proposes a scheduling method based on the virtual flattened architecture for hierarchical SOC, which breaks the hierarchical architecture to the virtual flattened one. Moreover, this method has more advantages compared with the traditional one, which tests the parent cores and child cores separately. Finally, the method is verified by the ITC'02 benchmark, and gives good results that reduce the test time and overhead effectively.

  12. Tunable ultracompact chip-integrated multichannel filter based on plasmon-induced transparencies

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Xiaoyu; Chai, Zhen; Lu, Cuicui; Yang, Hong [State Key Laboratory for Mesoscopic Physics and Department of Physics, Peking University, Beijing 100871 (China); Hu, Xiaoyong, E-mail: xiaoyonghu@pku.edu.cn, E-mail: qhgong@pku.edu.cn; Gong, Qihuang, E-mail: xiaoyonghu@pku.edu.cn, E-mail: qhgong@pku.edu.cn [State Key Laboratory for Mesoscopic Physics and Department of Physics, Peking University, Beijing 100871 (China); Collaborative Innovation Center of Quantum Matter, Beijing 100871 (China)

    2014-06-02

    Nanoscale multichannel filter is realized in plasmonic circuits directly, which consists of four plasmonic nanocavities coupled via a plasmonic waveguide etched in a gold film. The feature device size is only 1.35 μm, which is reduced by five orders of magnitude compared with previous reports. The optical channels are formed by transparency windows of plasmon-induced transparencies. A shift of 45 nm in the central wavelengths of optical channels is obtained when the plasmonic coupled-nanocavities are covered with a 100-nm-thick poly(methyl methacrylate) layer. This work opens up the possibility for the realization of solid quantum chips based on plasmonic circuits.

  13. On-chip dual-comb based on quantum cascade laser frequency combs

    Energy Technology Data Exchange (ETDEWEB)

    Villares, G., E-mail: gustavo.villares@phys.ethz.ch; Wolf, J.; Kazakov, D.; Süess, M. J.; Beck, M.; Faist, J., E-mail: jfaist@phys.ethz.ch [Institute for Quantum Electronics, ETH Zürich, CH-8093 Zürich (Switzerland); Hugi, A. [IRsweep GmbH, CH-8093 Zürich (Switzerland)

    2015-12-21

    Dual-comb spectroscopy is emerging as an appealing application of mid-infrared frequency combs for high-resolution molecular spectroscopy, as it leverages on the unique coherence properties of frequency combs. Here, we present an on-chip dual-comb source based on mid-infrared quantum cascade laser frequency combs. Control of the combs repetition and offset frequencies is obtained by integrating micro-heaters next to each laser. We show that a full control of the dual-comb system is possible, by measuring a multi-heterodyne beating corresponding to an optical bandwidth of 32 cm{sup −1} centered at 1330 cm{sup −1} (7.52 μm), demonstrating that this device represents a critical step towards compact dual-comb systems.

  14. Silicon-based on-chip electrically tunable sidewall Bragg grating Fabry-Perot filter.

    Science.gov (United States)

    Zhang, Weifeng; Ehteshami, Nasrin; Liu, Weilin; Yao, Jianping

    2015-07-01

    We report the design, fabrication, and testing of a silicon-based on-chip electrically tunable sidewall Bragg grating Fabry-Perot filter. Spectral measurement shows that the filter has a narrow notch in reflection of approximately 46 pm, a Q-factor of 33,500, and an extinction ratio of 16.4 dB. DC measurement shows that the average central wavelength shift rates with forward and reverse bias are -1.15  nm/V and 4.2  pm/V, respectively. Due to strong light confinement in the Fabry-Perot cavity, the electro-optic frequency response shows that the filter has a 3-dB modulation bandwidth of ∼5.6  GHz. The performance of using the filter to perform modulation of a 3.5  Gb/s2(7)-1 nonreturn-to-zero pseudorandom binary sequence is evaluated.

  15. Fabrication LSPR sensor chip of Ag NPs and their biosensor application based on interparticle coupling

    Energy Technology Data Exchange (ETDEWEB)

    Ghodselahi, T., E-mail: t_ghodselahi@yahoo.com [Nano Mabna Iranian Inc., PO Box 1676664116, Tehran (Iran, Islamic Republic of); School of Physics, Institute for Research in Fundamental Sciences, PO Box 19395-5531, Tehran (Iran, Islamic Republic of); Neishaboorynejad, T. [School of Physics, Institute for Research in Fundamental Sciences, PO Box 19395-5531, Tehran (Iran, Islamic Republic of); Department of Physics, Central Tehran Branch, Islamic Azad University, Tehran (Iran, Islamic Republic of); Arsalani, S. [School of Physics, Institute for Research in Fundamental Sciences, PO Box 19395-5531, Tehran (Iran, Islamic Republic of); School of Medicine, Bam University of Medical Sciences, Bam (Iran, Islamic Republic of)

    2015-07-15

    Highlights: • Localized surface plasmon resonance (LSPR) sensor of silver nanoparticles on hydrogenated amorphous carbon thin film were synthetized by co-deposition of RF-sputtering and RF-PECVD. • Samples were characterized by XRD, XPS, AFM, and UV visible. • DNA primer at fM concentration was detected based on breaking of inter-particles coupling. • Dipolar plasmon of isolated Ag NPs, coupled Ag NPs plasmons, in-plane and out-plane coupling, and quadrupole plasmon modes were considered to explain biosensor properties. • The initial response, wavelength shift sensitivity, and response time of LSPR sensors were compared by morphology. - Abstract: We introduce a simple method to synthesize localized surface plasmon resonance (LSPR) sensor chip of Ag NPs on the hydrogenated amorphous carbon by co-deposition of RF-Sputtering and RF-PECVD. The X-ray photoelectron spectroscopy revealed the content of Ag and C atoms. X-ray diffraction profile and atomic force microscopy indicate that the Ag NPs have fcc crystal structure and spherical shape and by increasing deposition time, particle sizes do not vary and only Ag NPs aggregation occurs, resulting in LSPR wavelength shift. Firstly, by increasing Ag NPs content, in-plan interparticles coupling is dominant and causes redshift in LSPR. At the early stage of agglomeration, out-plane coupling occurs and in-plane coupling is reduced, resulting a blueshift in the LSPR. By further increasing of Ag NPs content, agglomeration is completed on the substrate and in-plan coupling rises, resulting significant redshift in the LSPR. Results were used to implement biosensor application of chips. Detection of DNA primer at fM concentration was achieved based on breaking interparticles coupling of Ag NPs. A significant wavelength shift sensitivity of 30 nm and a short response time of 30 min were obtained, where both of these are prerequisite for biosensor applications.

  16. DNA mutation detection with chip-based temperature gradient capillary electrophoresis using a slantwise radiative heating system.

    Science.gov (United States)

    Zhang, Hui-Dan; Zhou, Jing; Xu, Zhang-Run; Song, Jin; Dai, Jing; Fang, Jin; Fang, Zhao-Lun

    2007-09-01

    A simple and robust chip-based temperature gradient capillary electrophoresis (TGCE) system was developed for DNA mutation/single-nucleotide polymorphism (SNP) analysis using a radiative heating system. Reproducible, stable and uniform temperature gradients were established along a 3 cm length of the electrophoretic separation channel using a single thermostated aluminium heater plate. The heater was slightly slanted relative to the plane of the glass chip at 0.2-1.3 degrees by inserting thin spacers between the plate and chip at one end to produce differences in radiative heating that created the temperature gradient. On-chip TGCE analyses of 4 mutant DNA model samples amplified from plasmid templates, each containing a single base substitution, with a wide range of melting temperatures, showed that mutations were successfully detected under a wide temperature gradient of 10 degrees C and within a short gradient region of about 3 cm (3.3 degrees C cm(-1) gradient). The radiative heating system was able to establish stable spatial temperature gradients along short microfluidic separation channels using simple peripheral equipment and manipulation while ensuring good resolution for detecting a wide range of mutations. Effectiveness of the system was demonstrated by the successful detection of K-ras gene mutations in 6 colon cancer cell lines.

  17. Period of the d-Sequence Based Random Number Generator

    OpenAIRE

    Thippireddy, Suresh; Chalasani, Sandeep

    2007-01-01

    This paper presents an expression to compute the exact period of a recursive random number generator based on d-sequences. Using the multi-recursive version of this generator we can produce large number of pseudorandom sequences.

  18. A novel rabbit immunospot array assay on a chip allows for the rapid generation of rabbit monoclonal antibodies with high affinity.

    Directory of Open Access Journals (Sweden)

    Tatsuhiko Ozawa

    Full Text Available Antigen-specific rabbit monoclonal antibodies (RaMoAbs are useful due to their high specificity and high affinity, and the establishment of a comprehensive and rapid RaMoAb generation system has been highly anticipated. Here, we present a novel system using immunospot array assay on a chip (ISAAC technology in which we detect and retrieve antigen-specific antibody-secreting cells from the peripheral blood lymphocytes of antigen-immunized rabbits and produce antigen-specific RaMoAbs with 10(-12 M affinity within a time period of only 7 days. We have used this system to efficiently generate RaMoAbs that are specific to a phosphorylated signal-transducing molecule. Our system provides a new method for the comprehensive and rapid production of RaMoAbs, which may contribute to laboratory research and clinical applications.

  19. Generating IDS Attack Pattern Automatically Based on Attack Tree

    Institute of Scientific and Technical Information of China (English)

    向尕; 曹元大

    2003-01-01

    Generating attack pattern automatically based on attack tree is studied. The extending definition of attack tree is proposed. And the algorithm of generating attack tree is presented. The method of generating attack pattern automatically based on attack tree is shown, which is tested by concrete attack instances. The results show that the algorithm is effective and efficient. In doing so, the efficiency of generating attack pattern is improved and the attack trees can be reused.

  20. Reliability-based generation resource planning in electricity markets

    OpenAIRE

    Moghaddam, Maziar Mirhosseini; Javidi, Mohammad Hossein

    2014-01-01

    This paper proposes a reliability-based competitive generation resource planning model in electricity markets. The Monte Carlo simulation method is applied to consider random outages of generation units and transmission lines as well as load uncertainty. In order to determine the optimal plan for installation of candidate generating units, the decisions of generation companies (GenCos) and the independent system operators (ISOs) are investigated. The method is based on an iterative pro...

  1. Avoiding Message-Dependent Deadlock in Network-Based Systems on Chip

    NARCIS (Netherlands)

    Hansson, A.; Goossens, K.; Rãdulescu, A.

    2007-01-01

    Networks on chip (NoCs) are an essential component of systems on chip (SoCs) and much research is devoted to deadlock avoidance in NoCs. Prior work focuses on the router network while protocol interactions between NoC and intellectual property (IP) modules are not considered. These interactions intr

  2. Smart portable electrophoresis instrument based on multipurpose microfluidic chips with electrochemical detection.

    Science.gov (United States)

    Fernández-la-Villa, Ana; Sánchez-Barragán, Dámaso; Pozo-Ayuso, Diego F; Castaño-Álvarez, Mario

    2012-09-01

    A second generation of a battery-powered portable electrophoresis instrument for the use of ME with electrochemical detection was developed. As the first-generation, the main unit of the instrument (150 mm × 165 mm × 95 mm) consists of four-outputs high-voltage power supply (HVPS) with maximum voltage of 3 KV and acquisition system (bipotentiostat) containing 2-channels for dual electrochemical detection. A new reusable microfluidic platform was designed in order to incorporate the microchips with the portable instrument. In this case, the platform is integrated to the main unit of the instrument so that it is not necessary to have any external cable for the interconnection of both parts, making the use of the complete system easier. The new platform contains all the electrical connections for the HVPS and bipotentiostat, as well as fluidic ports for driving the solutions. The microfluidic electrophoresis instrument is controlled by means of a user-friendly interface from a computer. The possibility of wireless connection (Bluetooth®) allows the use of the instrument without any external cable improving the portability. Therefore, the second generation brings a more compact and integrated electrophoresis instrument for "in situ" applications using microfluidic chips in an easy way. The performance of the electrophoresis system was initially evaluated using single- and dual-channel SU-8/Pyrex microchips with different models of integrated electrodes including microelectrodes and interdigitated arrays. The method was tested in different analytical applications such as separation of neurotransmitters, chlorophenols, purine derivatives, vitamins, polyphenolic acids, and flavones.

  3. A 3D Microfluidic Chip for Electrochemical Detection of Hydrolysed Nucleic Bases by a Modified Glassy Carbon Electrode

    Directory of Open Access Journals (Sweden)

    Jana Vlachova

    2015-01-01

    Full Text Available Modification of carbon materials, especially graphene-based materials, has wide applications in electrochemical detection such as electrochemical lab-on-chip devices. A glassy carbon electrode (GCE modified with chemically alternated graphene oxide was used as a working electrode (glassy carbon modified by graphene oxide with sulphur containing compounds and Nafion for detection of nucleobases in hydrolysed samples (HCl pH = 2.9, 100 °C, 1 h, neutralization by NaOH. It was found out that modification, especially with trithiocyanuric acid, increased the sensitivity of detection in comparison with pure GCE. All processes were finally implemented in a microfluidic chip formed with a 3D printer by fused deposition modelling technology. As a material for chip fabrication, acrylonitrile butadiene styrene was chosen because of its mechanical and chemical stability. The chip contained the one chamber for the hydrolysis of the nucleic acid and another for the electrochemical detection by the modified GCE. This chamber was fabricated to allow for replacement of the GCE.

  4. Immobilization of zebrafish larvae on a chip-based device for environmental scanning electron microscopy (ESEM) imaging

    Science.gov (United States)

    Akagi, Jin; Hall, Chris J.; Crosier, Kathryn E.; Crosier, Philip S.; Wlodkowic, Donald

    2013-12-01

    Small vertebrate model organisms have recently gained popularity as attractive experimental models that enhance our understanding of human tissue and organ development. Laser microsurgery on zebrafish larvae combined with Scanning Electron Microscopy (SEM) imaging can in particular provide accelerated insights into the tissue regeneration phenomena. Conventional SEM exposes, however, specimens to high vacuum environments, and often requires laborintensive and time-consuming pretreatments and manual positioning. Moreover, there are virtually no technologies available that can quickly immobilize the zebrafish larvae for high definition SEM imaging. This work describes the proof-of-concept design and validation of a microfluidic chip-based system for immobilizing zebrafish larvae and it's interfacing with Environmental Scanning Electron Microscope (ESEM) imaging. The Lab-on-a-Chip (LOC) device was fabricated using a high-speed infrared laser micromachining and consists of a reservoir with multiple semispherical microwells, which hold the yolk of zebrafish larvae, and drain channels that allow removing excess of medium during SEM imaging. Paper filter is used to actuate the chip and immobilization of the larvae by gentle suction that occurs during water drainage. The trapping region allows multiple specimens to be positioned on the chip. The device is then inserted directly inside the ESEM and imaged in a near 100% humidity atmosphere. This facilitates ESEM imaging of untreated biological samples.

  5. Dynamically Generated Interfaces in XML Based Architecture

    CERN Document Server

    Gupta, Minit

    2009-01-01

    Providing on-line services on the Internet will require the definition of flexible interfaces that are capable of adapting to the user's characteristics. This is all the more important in the context of medical applications like home monitoring, where no two patients have the same medical profile. Still, the problem is not limited to the capacity of defining generic interfaces, as has been made possible by UIML, but also to define the underlying information structures from which these may be generated. The DIATELIC project deals with the tele-monitoring of patients under peritoneal dialysis. By means of XML abstractions, termed as "medical components", to represent the patient's profile, the application configures the customizable properties of the patient's interface and generates a UIML document dynamically. The interface allows the patient to feed the data manually or use a device which allows "automatic data acquisition". The acquired medical data is transferred to an expert system, which analyses the dat...

  6. Recent Advances in Room Temperature, High-Power Terahertz Quantum Cascade Laser Sources Based on Difference-Frequency Generation

    OpenAIRE

    Quanyong Lu; Manijeh Razeghi

    2016-01-01

    We present the current status of high-performance, compact, THz sources based on intracavity nonlinear frequency generation in mid-infrared quantum cascade lasers. Significant performance improvements of our THz sources in the power and wall plug efficiency are achieved by systematic optimizing the device’s active region, waveguide, and chip bonding strategy. High THz power up to 1.9 mW and 0.014 mW for pulsed mode and continuous wave operations at room temperature are demonstrated, respectiv...

  7. Chip-based in situ hybridization for identification of bacteria from the human microbiome.

    Energy Technology Data Exchange (ETDEWEB)

    Light, Yooli Kim; Meagher, Robert J.; Singh, Anup K.; Liu, Peng

    2010-11-01

    The emerging field of metagenomics seeks to assess the genetic diversity of complex mixed populations of bacteria, such as those found at different sites within the human body. A single person's mouth typically harbors up to 100 bacterial species, while surveys of many people have found more than 700 different species, of which {approx}50% have never been cultivated. In typical metagenomics studies, the cells themselves are destroyed in the process of gathering sequence information, and thus the connection between genotype and phenotype is lost. A great deal of sequence information may be generated, but it is impossible to assign any given sequence to a specific cell. We seek non-destructive, culture-independent means of gathering sequence information from selected individual cells from mixed populations. As a first step, we have developed a microfluidic device for concentrating and specifically labeling bacteria from a mixed population. Bacteria are electrophoretically concentrated against a photopolymerized membrane element, and then incubated with a specific fluorescent label, which can include antibodies as well as specific or non-specific nucleic acid stains. Unbound stain is washed away, and the labeled bacteria are released from the membrane. The stained cells can then be observed via epifluorescence microscopy, or counted via flow cytometry. We have tested our device with three representative bacteria from the human microbiome: E. coli (gut, Gram-negative), Lactobacillus acidophilus (mouth, Gram-positive), and Streptococcus mutans (mouth, Gram-positive), with results comparable to off-chip labeling techniques.

  8. Design and Fabrication of a Chip-based Continuous-wave Atom Laser

    CERN Document Server

    Power, E P; Vanderelzen, B; Herrera-Fierro, P; Murphy, R; Yalisove, S M; Raithel, G

    2012-01-01

    We present a design for a continuous-wave (CW) atom laser on a chip and describe the process used to fabricate the device. Our design aims to integrate quadrupole magnetic guiding of ground state Rb atoms with continuous surface adsorption evaporative cooling to create a continuous Bose-Einstein condensate; out-coupled atoms from the condensate should realize a CW atom laser. We choose a geometry with three wires embedded in a spiral pattern in a silicon subtrate. The guide features an integrated solenoid to mitigate spin-flip losses and provide a tailored longitudinal magnetic field. Our design also includes multiple options for atom interferometry: accomodations are in place for laser-generated atom Fabry-Perot and Mach-Zehnder interferometers, and a pair of atomic beam X-splitters is incorporated for an all-magnetic atom Mach-Zehnder setup. We demonstrate the techniques necessary to fabricate our device using existing micro- and nano-scale fabrication equipment, and discuss future options for modified desi...

  9. Entangled photons from on-chip slow light

    CERN Document Server

    Takesue, Hiroki; Kuramochi, Eiichi; Notomi, Masaya

    2014-01-01

    We report the first entanglement generation experiment using an on-chip slow light device. With highly efficient spontaneous four-wave mixing enhanced by the slow light effect in a coupled resonator optical waveguide based on a silicon photonic crystal, we generated 1.5-$\\mu$m-band high-dimensional time-bin entangled photon pairs. We undertook two-photon interference experiments and observed the coincidence fringes with visibilities $>74\\%$. The present result enables us to realize an on-chip entanglement source with a very small footprint, which is an essential function for quantum information processing based on integrated quantum photonics.

  10. Implementation of a Test Data Generator based on DSL Files

    Directory of Open Access Journals (Sweden)

    Paul POCATILU

    2016-01-01

    Full Text Available In software testing process, test data generation represents an important step for high quality software, even for mobile devices. As proposed in previous works, a potential source for random data generation is represented by the UI layout files that are used for almost all mobile platforms (Android, iOS, Windows Phone/Mobile. This paper continues the previous work and presents a test data generation system based on Android layout files. The test data generator uses DSL files as input and generates test data that conform to several testing principles. The generated test data could be stored in XML files or any format required by the testing frameworks.

  11. "Hook"-calibration of GeneChip-microarrays: Chip characteristics and expression measures

    Directory of Open Access Journals (Sweden)

    Krohn Knut

    2008-08-01

    Full Text Available Abstract Background Microarray experiments rely on several critical steps that may introduce biases and uncertainty in downstream analyses. These steps include mRNA sample extraction, amplification and labelling, hybridization, and scanning causing chip-specific systematic variations on the raw intensity level. Also the chosen array-type and the up-to-dateness of the genomic information probed on the chip affect the quality of the expression measures. In the accompanying publication we presented theory and algorithm of the so-called hook method which aims at correcting expression data for systematic biases using a series of new chip characteristics. Results In this publication we summarize the essential chip characteristics provided by this method, analyze special benchmark experiments to estimate transcript related expression measures and illustrate the potency of the method to detect and to quantify the quality of a particular hybridization. It is shown that our single-chip approach provides expression measures responding linearly on changes of the transcript concentration over three orders of magnitude. In addition, the method calculates a detection call judging the relation between the signal and the detection limit of the particular measurement. The performance of the method in the context of different chip generations and probe set assignments is illustrated. The hook method characterizes the RNA-quality in terms of the 3'/5'-amplification bias and the sample-specific calling rate. We show that the proper judgement of these effects requires the disentanglement of non-specific and specific hybridization which, otherwise, can lead to misinterpretations of expression changes. The consequences of modifying probe/target interactions by either changing the labelling protocol or by substituting RNA by DNA targets are demonstrated. Conclusion The single-chip based hook-method provides accurate expression estimates and chip-summary characteristics

  12. Network on Chip: a New Approach of QoS Metric Modeling Based on Calculus Theory

    Directory of Open Access Journals (Sweden)

    Salem NASRI

    2011-10-01

    Full Text Available According to ITRS, in 2018, ICs will be able to integrate billions of transistors, with feature sizes around 18 nm and clock frequencies near to 10 GHz. In this context, Network on Chip (NoC appears as an attractive solution to implement future high performance networks and more QoS management. A NoC is composed by IP cores (Intellectual Propriety and switches connected among themselves by communicationchannels. End-to-End Delay (EED communication is accomplished by the exchange of data among IP cores.Often, the structure of particular messages is not adequate for the communication purposes. This leads to the concept of packet switching. In the context of NoCs, packets are composed by header, payload, and trailer. Packets are divided into small pieces called Flits. It appears of importance, to meet the required performance in NoC hardware resources. It should be specified in an earlier step of the system design. The main attention should be given to the choice of some network parameters such as the physical buffer size in the node. The EED and packet loss are some of the critical QoS metrics. Some real-time and multimedia applications bound up these parameters and require specific hardware resources and particular management approaches in the NoC switch.A traffic contract (SLA, Service Level Agreement specifies the ability of a network or protocol to give guaranteed performance, throughput or latency bounds based on mutually agreed measures, usually by prioritizing traffic. A defined Quality of Service (QoS may be required for some types of network real time traffic or multimedia applications. The main goal of this paper is, using the Network on Chip modeling architecture, to define a QoS metric. We focus on the network delay bound and packet losses. This approach is based on the Network Calculus theory, a mathematical model to represent the data flows behavior between IPs interconnected over NoC.We propose an approach of QoS-metric based on Qo

  13. On-Chip Isothermal Nucleic Acid Amplification on Flow-Based Chemiluminescence Microarray Analysis Platform for the Detection of Viruses and Bacteria.

    Science.gov (United States)

    Kunze, A; Dilcher, M; Abd El Wahed, A; Hufert, F; Niessner, R; Seidel, M

    2016-01-01

    This work presents an on-chip isothermal nucleic acid amplification test (iNAAT) for the multiplex amplification and detection of viral and bacterial DNA by a flow-based chemiluminescence microarray. In a principle study, on-chip recombinase polymerase amplification (RPA) on defined spots of a DNA microarray was used to spatially separate the amplification reaction of DNA from two viruses (Human adenovirus 41, Phi X 174) and the bacterium Enterococcus faecalis, which are relevant for water hygiene. By establishing the developed assay on the microarray analysis platform MCR 3, the automation of isothermal multiplex-amplification (39 °C, 40 min) and subsequent detection by chemiluminescence imaging was realized. Within 48 min, the microbes could be identified by the spot position on the microarray while the generated chemiluminescence signal correlated with the amount of applied microbe DNA. The limit of detection (LOD) determined for HAdV 41, Phi X 174, and E. faecalis was 35 GU/μL, 1 GU/μL, and 5 × 10(3) GU/μL (genomic units), which is comparable to the sensitivity reported for qPCR analysis, respectively. Moreover the simultaneous amplification and detection of DNA from all three microbes was possible. The presented assay shows that complex enzymatic reactions like an isothermal amplification can be performed in an easy-to-use experimental setup. Furthermore, iNAATs can be potent candidates for multipathogen detection in clinical, food, or environmental samples in routine or field monitoring approaches.

  14. Sensitivity enhancement of a grating-based surface plasmon-coupled emission (SPCE) biosensor chip using gold thickness

    Science.gov (United States)

    Yuk, Jong Seol; Guignon, Ernest F.; Lynes, Michael A.

    2014-01-01

    We describe a novel approach to enhance the sensitivity of a grating-based surface plasmon-coupled emission (SPCE) sensor by increasing the thickness of the metal film used in this system. The calculated optical properties of grating-based SPR spectra were significantly affected by both grating depth and by gold thickness. Higher angular sensitivity could be achieved at short wavelengths and under in situ measurement (analysis under aqueous condition). We confirmed the predicated enhancements of SPCE response using Alexa Fluor 647-labeled anti-mouse IgG immobilized on the SPCE sensor chips. Grating-coupled SPCE sensor chips can be used as a useful tool for high contents analysis of chemical and biomolecular interactions.

  15. Chip-Based Measurements of Brownian Relaxation of Magnetic Beads Using a Planar Hall Effect Magnetic Field Sensor

    Science.gov (United States)

    Østerberg, Frederik W.; Dalslet, Bjarke T.; Snakenborg, Detlef; Johansson, Christer; Hansen, Mikkel F.

    2010-12-01

    We present a simple `click-on' fluidic system with integrated electrical contacts, which is suited for electrical measurements on chips in microfluidic systems. We show that microscopic magnetic field sensors based on the planar Hall effect can be used for detecting the complex magnetic response using only the self-field arising from the bias current applied to the sensors as excitation field. We present measurements on a suspension of magnetic beads with a nominal diameter of 250 nm vs. temperature and find that the observations are consistent with the Cole-Cole model for Brownian relaxation with a constant hydrodynamic bead diameter when the temperature dependence of the viscosity of water is taken into account. These measurements demonstrate the feasibility of performing measurements of the Brownian relaxation response in a lab-on-a-chip system and constitute the first step towards an integrated biosensor based on the detection of the dynamic response of magnetic beads.

  16. Ontodog: a web-based ontology community view generation tool.

    Science.gov (United States)

    Zheng, Jie; Xiang, Zuoshuang; Stoeckert, Christian J; He, Yongqun

    2014-05-01

    Biomedical ontologies are often very large and complex. Only a subset of the ontology may be needed for a specified application or community. For ontology end users, it is desirable to have community-based labels rather than the labels generated by ontology developers. Ontodog is a web-based system that can generate an ontology subset based on Excel input, and support generation of an ontology community view, which is defined as the whole or a subset of the source ontology with user-specified annotations including user-preferred labels. Ontodog allows users to easily generate community views with minimal ontology knowledge and no programming skills or installation required. Currently >100 ontologies including all OBO Foundry ontologies are available to generate the views based on user needs. We demonstrate the application of Ontodog for the generation of community views using the Ontology for Biomedical Investigations as the source ontology.

  17. Model Based Analysis and Test Generation for Flight Software

    Science.gov (United States)

    Pasareanu, Corina S.; Schumann, Johann M.; Mehlitz, Peter C.; Lowry, Mike R.; Karsai, Gabor; Nine, Harmon; Neema, Sandeep

    2009-01-01

    We describe a framework for model-based analysis and test case generation in the context of a heterogeneous model-based development paradigm that uses and combines Math- Works and UML 2.0 models and the associated code generation tools. This paradigm poses novel challenges to analysis and test case generation that, to the best of our knowledge, have not been addressed before. The framework is based on a common intermediate representation for different modeling formalisms and leverages and extends model checking and symbolic execution tools for model analysis and test case generation, respectively. We discuss the application of our framework to software models for a NASA flight mission.

  18. Optical Generation of Fuzzy-Based Rules

    Science.gov (United States)

    Gur, Eran; Mendlovic, David; Zalevsky, Zeev

    2002-08-01

    In the last third of the 20th century, fuzzy logic has risen from a mathematical concept to an applicable approach in soft computing. Today, fuzzy logic is used in control systems for various applications, such as washing machines, train-brake systems, automobile automatic gear, and so forth. The approach of optical implementation of fuzzy inferencing was given by the authors in previous papers, giving an extra emphasis to applications with two dominant inputs. In this paper the authors introduce a real-time optical rule generator for the dual-input fuzzy-inference engine. The paper briefly goes over the dual-input optical implementation of fuzzy-logic inferencing. Then, the concept of constructing a set of rules from given data is discussed. Next, the authors show ways to implement this procedure optically. The discussion is accompanied by an example that illustrates the transformation from raw data into fuzzy set rules.

  19. Meta-data based mediator generation

    Energy Technology Data Exchange (ETDEWEB)

    Critchlaw, T

    1998-06-28

    Mediators are a critical component of any data warehouse; they transform data from source formats to the warehouse representation while resolving semantic and syntactic conflicts. The close relationship between mediators and databases requires a mediator to be updated whenever an associated schema is modified. Failure to quickly perform these updates significantly reduces the reliability of the warehouse because queries do not have access to the most current data. This may result in incorrect or misleading responses, and reduce user confidence in the warehouse. Unfortunately, this maintenance may be a significant undertaking if a warehouse integrates several dynamic data sources. This paper describes a meta-data framework, and associated software, designed to automate a significant portion of the mediator generation task and thereby reduce the effort involved in adapting to schema changes. By allowing the DBA to concentrate on identifying the modifications at a high level, instead of reprogramming the mediator, turnaround time is reduced and warehouse reliability is improved.

  20. Design and experimental verification of CMOS magnetic-based microbead detection using an asynchronous intra-chip inductive-coupling transceiver

    Science.gov (United States)

    Niitsu, Kiichi; Kobayashi, Atsuki; Yoshida, Kohei; Nakazato, Kazuo

    2017-01-01

    In this study, an asynchronous intra-chip inductive-coupling transceiver was used to design and experimentally verify a CMOS magnetic-based microbeads detection system. Magnetic microbeads were employed for the surrounding living cells. These microbeads increased the magnetic flux and enabled the operation of an intra-chip inductive-coupling transceiver with a low transmitter supply voltage. Thus, by sensing the change in transmitter supply voltage, the system detected the living cells surrounded by microbeads. To verify the effectiveness of the proposed approach, a test chip was fabricated using 0.25 µm CMOS technology. The measured results successfully demonstrated the detection of microbeads.

  1. The Reliability of Randomly Generated Math Curriculum-Based Measurements

    Science.gov (United States)

    Strait, Gerald G.; Smith, Bradley H.; Pender, Carolyn; Malone, Patrick S.; Roberts, Jarod; Hall, John D.

    2015-01-01

    "Curriculum-Based Measurement" (CBM) is a direct method of academic assessment used to screen and evaluate students' skills and monitor their responses to academic instruction and intervention. Interventioncentral.org offers a math worksheet generator at no cost that creates randomly generated "math curriculum-based measures"…

  2. Patterned Fibers Embedded Microfluidic Chips Based on PLA and PDMS for Ag Nanoparticle Safety Testing

    Directory of Open Access Journals (Sweden)

    Yaowen Liu

    2016-11-01

    Full Text Available A new method to integrate poly-dl-lactide (PLA patterned electrospun fibers with a polydimethylsiloxane (PDMS microfluidic chip was successfully developed via lithography. Hepatocyte behavior under static and dynamic conditions was investigated. Immunohistochemical analyses indicated good hepatocyte survival under the dynamic culture system with effective hepatocyte spheroid formation in the patterned microfluidic chip vs. static culture conditions and tissue culture plate (TCP. In particular, hepatocytes seeded in this microfluidic chip under a flow rate of 10 μL/min could re-establish hepatocyte polarity to support biliary excretion and were able to maintain high levels of albumin and urea secretion over 15 days. Furthermore, the optimized system could produce sensitive and consistent responses to nano-Ag-induced hepatotoxicity during culture. Thus, this microfluidic chip device provides a new means of fabricating complex liver tissue-engineered scaffolds, and may be of considerable utility in the toxicity screening of nanoparticles.

  3. Network Generation Model Based on Evolution Dynamics To Generate Benchmark Graphs

    CERN Document Server

    Pasta, Muhammad Qasim

    2016-01-01

    Network generation models provide an understanding of the dynamics behind the formation and evolution of different networks including social networks, technological networks and biological networks. Two important applications of these models are to study the evolution dynamics of network formation and to generate benchmark networks with known community structures. Research has been conducted in both these directions relatively independent of the other application area. This creates a disjunct between real world networks and the networks generated to study community detection algorithms. In this paper, we propose to study both these application areas together i.e.\\ introduce a network generation model based on evolution dynamics of real world networks and generate networks with community structures that can be used as benchmark graphs to study community detection algorithms. The generated networks possess tunable modular structures which can be used to generate networks with known community structures. We stud...

  4. SERS-based multiple biomarker detection using a gold-patterned microarray chip

    Science.gov (United States)

    Kim, Insup; Junejo, Inam-ur-Rehman; Lee, Moonkwon; Lee, Sangyeop; Lee, Eun Kyu; Chang, Soo-Ik; Choo, Jaebum

    2012-09-01

    We report a highly sensitive surface-enhanced Raman scattering (SERS)-based immunoassay platform for the multiplex detection of biomarkers. For this purpose, a gold-patterned microarray chip has been fabricated and used as a SERS detection template. Here, a typical sandwich immunocomplex protocol was adopted. Monoclonal antibodies were immobilized on gold patterned substrates, and then antigen solutions and polyclonal antibody-conjugated hollow gold nanospheres (HGNs) were sequentially added for the formation of sandwich immunocomplexes. Antigen biomarkers can be quantitatively assayed by monitoring the intensity change of a characteristic SERS peak of a reporter molecule adsorbed on the surfaces of HGNs. Under optimized assay conditions, the limits of detections (LODs) were determined to be 10 fg/mL for human IgG and 10-100 fg/mL for rabbit IgG. In addition, the SERS-based immunoassay technique can be applied in a wider dynamic concentration range with a good sensitivity compared to ELISA. The proposed method fulfills the current needs of high sensitivity and selectivity which are essential for the clinical diagnosis of a disease.

  5. (Re)configuration based on model generation

    CERN Document Server

    Friedrich, Gerhard; Falkner, Andreas A; Haselböck, Alois; Schenner, Gottfried; Schreiner, Herwig; 10.4204/EPTCS.65.3

    2011-01-01

    Reconfiguration is an important activity for companies selling configurable products or services which have a long life time. However, identification of a set of required changes in a legacy configuration is a hard problem, since even small changes in the requirements might imply significant modifications. In this paper we show a solution based on answer set programming, which is a logic-based knowledge representation formalism well suited for a compact description of (re)configuration problems. Its applicability is demonstrated on simple abstractions of several real-world scenarios. The evaluation of our solution on a set of benchmark instances derived from commercial (re)configuration problems shows its practical applicability.

  6. Silicon-nanowire based attachment of silicon chips for mouse embryo labelling.

    Science.gov (United States)

    Durán, S; Novo, S; Duch, M; Gómez-Martínez, R; Fernández-Regúlez, M; San Paulo, A; Nogués, C; Esteve, J; Ibañez, E; Plaza, J A

    2015-03-21

    The adhesion of small silicon chips to cells has many potential applications as direct interconnection of the cells to the external world can be accomplished. Hence, although some typical applications of silicon nanowires integrated into microsystems are focused on achieving a cell-on-a-chip strategy, we are interested in obtaining chip-on-a-cell systems. This paper reports the design, technological development and characterization of polysilicon barcodes featuring silicon nanowires as nanoscale attachment to identify and track living mouse embryos during their in vitro development. The chips are attached to the outer surface of the Zona Pellucida, the cover that surrounds oocytes and embryos, to avoid the direct contact between the chip and the embryo cell membrane. Two attachment methodologies, rolling and pushpin, which allow two entirely different levels of applied forces to attach the chips to living embryos, are evaluated. The former consists of rolling the mouse embryos over one barcode with the silicon nanowires facing upwards, while in the latter, the barcode is pushed against the embryo with a micropipette. The effect on in vitro embryo development and the retention rate related to the calculated applied forces are stated. Field emission scanning electron microscopy inspection, which allowed high-resolution imaging, also confirms the physical attachment of the nanowires with some of them piercing or wrapped by the Zona Pellucida and revealed extraordinary bent silicon nanowires.

  7. Atom chip apparatus for experiments with ultracold rubidium and potassium gases

    Energy Technology Data Exchange (ETDEWEB)

    Ivory, M. K.; Ziltz, A. R.; Fancher, C. T.; Pyle, A. J.; Sensharma, A.; Chase, B.; Field, J. P.; Garcia, A.; Aubin, S., E-mail: saaubi@wm.edu [Department of Physics, College of William and Mary, Williamsburg, Virginia 23187 (United States); Jervis, D. [Department of Physics, University of Toronto, Toronto, Ontario M5S 1A7 (Canada)

    2014-04-15

    We present a dual chamber atom chip apparatus for generating ultracold {sup 87}Rb and {sup 39}K atomic gases. The apparatus produces quasi-pure Bose-Einstein condensates of 10{sup 4} {sup 87}Rb atoms in an atom chip trap that features a dimple and good optical access. We have also demonstrated production of ultracold {sup 39}K and subsequent loading into the chip trap. We describe the details of the dual chamber vacuum system, the cooling lasers, the magnetic trap, the multicoil magnetic transport system, the atom chip, and two optical dipole traps. Due in part to the use of light-induced atom desorption, the laser cooling chamber features a sufficiently good vacuum to also support optical dipole trap-based experiments. The apparatus is well suited for studies of atom-surface forces, quantum pumping and transport experiments, atom interferometry, novel chip-based traps, and studies of one-dimensional many-body systems.

  8. Atom chip apparatus for experiments with ultracold rubidium and potassium gases.

    Science.gov (United States)

    Ivory, M K; Ziltz, A R; Fancher, C T; Pyle, A J; Sensharma, A; Chase, B; Field, J P; Garcia, A; Jervis, D; Aubin, S

    2014-04-01

    We present a dual chamber atom chip apparatus for generating ultracold (87)Rb and (39)K atomic gases. The apparatus produces quasi-pure Bose-Einstein condensates of 10(4) (87)Rb atoms in an atom chip trap that features a dimple and good optical access. We have also demonstrated production of ultracold (39)K and subsequent loading into the chip trap. We describe the details of the dual chamber vacuum system, the cooling lasers, the magnetic trap, the multicoil magnetic transport system, the atom chip, and two optical dipole traps. Due in part to the use of light-induced atom desorption, the laser cooling chamber features a sufficiently good vacuum to also support optical dipole trap-based experiments. The apparatus is well suited for studies of atom-surface forces, quantum pumping and transport experiments, atom interferometry, novel chip-based traps, and studies of one-dimensional many-body systems.

  9. Mechanically based generative laws of morphogenesis

    Science.gov (United States)

    Beloussov, Lev V.

    2008-03-01

    A deep (although at the first glance naïve) question which may be addressed to embryonic development is why during this process quite definite and accurately reproduced successions of precise and complicated shapes are taking place, or why, in several cases, the result of development is highly precise in spite of an extensive variability of intermediate stages. This problem can be attacked in two different ways. One of them, up to now just slightly employed, is to formulate robust macroscopic generative laws from which the observed successions of shapes could be derived. Another one, which dominates in modern embryology, regards the development as a succession of highly precise 'micropatterns', each of them arising due to the action of specific factors, having, as a rule, nothing in common with each other. We argue that the latter view contradicts a great bulk of firmly established data and gives no satisfactory answers to the main problems of development. Therefore we intend to follow the first way. By doing this, we regard developing embryos as self-organized systems transpierced by feedbacks among which we pay special attention to those linked with mechanical stresses (MS). We formulate a hypothesis of so-called MS hyper-restoration as a common basis for the developmentally important feedback loops. We present a number of examples confirming this hypothesis and use it for reconstructing prolonged chains of developmental events. Finally, we discuss the application of the same set of assumptions to the first steps of egg development and to the internal differentiation of embryonic cells.

  10. Ternary jitter-based true random number generator

    Science.gov (United States)

    Latypov, Rustam; Stolov, Evgeni

    2017-01-01

    In this paper a novel family of generators producing true uniform random numbers in ternary logic is presented. The generator consists of a number of identical ternary logic combinational units connected into a ring. All the units are provided to have a random delay time, and this time is supposed to be distributed in accordance with an exponential distribution. All delays are supposed to be independent events. The theory of the generator is based on Erlang equations. The generator can be used for test production in various systems. Features of multidimensional random vectors, produced by the generator, are discussed.

  11. Chip-Based Measurements of Brownian Relaxation of Magnetic Beads Using a Planar Hall Effect Magnetic Field Sensor

    DEFF Research Database (Denmark)

    Østerberg, Frederik Westergaard; Dalslet, Bjarke Thomas; Snakenborg, Detlef

    2010-01-01

    We present a simple 'click-on' fluidic system with integrated electrical contacts, which is suited for electrical measurements on chips in microfluidic systems. We show that microscopic magnetic field sensors based on the planar Hall effect can be used for detecting the complex magnetic response...... with a constant hydrodynamic bead diameter when the temperature dependence of the viscosity of water is taken into account. These measurements demonstrate the feasibility of performing measurements of the Brownian relaxation response in a lab-on-a-chip system and constitute the first step towards an integrated...... using only the self-field arising from the bias current applied to the sensors as excitation field. We present measurements on a suspension of magnetic beads with a nominal diameter of 250 nm vs. temperature and find that the observations are consistent with the Cole-Cole model for Brownian relaxation...

  12. Design and Implementation of Embedded Transmission Control Protocol/Internet Protocol Network Based on System-on-programmable Chip

    Institute of Scientific and Technical Information of China (English)

    LUO Yong; HAN Xiao-jun

    2008-01-01

    A scheme of transmission control protocol/Internet protocol(TCP/IP) network system based on system-on-programmable chip(SOPC) is proposed for the embedded network communication. In this system, Nios processor, Ethernet controller and other peripheral logic circuits are all integrated on a Stratix Ⅱ field programmable gate array(FPGA) chip by using SOPC builder design software. And the network communication is realized by transplanting MicroC/OS Ⅱ(μC/OS Ⅱ) operation system and light weight Internet protocol(LwIP). The design idea, key points and the structures of both software and hardware of the system are presented and ran with a telecommunication example. The experiment shows that the embedded TCP/IP network system has high reliability and real-time performance.

  13. A Phase Change Memory Chip Based on TiSbTe Alloy in 40-nm Standard CMOS Technology

    Institute of Scientific and Technical Information of China (English)

    Zhitang Song; YiPeng Zhan; Daolin Cai; Bo Liu; Yifeng Chen; Jiadong Ren

    2015-01-01

    In this letter, a phase change random access memory (PCRAM) chip based on Ti0.4Sb2Te3 alloy material was fabricated in a 40-nm 4-metal level complementary metal-oxide semiconductor (CMOS) technology. The phase change resistor was then integrated after CMOS logic fabrication. The PCRAM was successfully embedded without changing any logic device and process, in which 1.1 V negative-channel metal-oxide semiconductor device was used as the memory cell selector. The currents and the time of SET and RESET operations were found to be 0.2 and 0.5 mA, 100 and 10 ns, respectively. The high speed performance of this chip may highlight the design advantages in many embedded applications.

  14. A versatile quantitation platform based on platinum nanoparticles incorporated volumetric bar-chart chip for highly sensitive assays.

    Science.gov (United States)

    Wang, Yuzhen; Zhu, Guixian; Qi, Wenjin; Li, Ying; Song, Yujun

    2016-11-15

    Platinum nanoparticles incorporated volumetric bar-chart chip (PtNPs-V-Chip) is able to be used for point-of-care tests by providing quantitative and visualized readout without any assistance from instruments, data processing, or graphic plotting. To improve the sensitivity of PtNPs-V-Chip, hybridization chain reaction was employed in this quantitation platform for highly sensitive assays that can detect as low as 16 pM Ebola Virus DNA, 0.01ng/mL carcinoembryonic antigen (CEA), and the 10 HER2-expressing cancer cells. Based on this amplified strategy, a 100-fold decrease of detection limit was achieved for DNA by improving the number of platinum nanoparticle catalyst for the captured analyte. This quantitation platform can also distinguish single base mismatch of DNA hybridization and observe the concentration threshold of CEA. The new strategy lays the foundation for this quantitation platform to be applied in forensic analysis, biothreat detection, clinical diagnostics and drug screening.

  15. Applications of stereolithography for rapid prototyping of biologically compatible chip-based physiometers

    Science.gov (United States)

    Fuad, Nurul Mohd; Zhu, Feng; Kaslin, Jan; Wlodkowic, Donald

    2016-12-01

    Despite the growing demand and numerous applications for the biomedical community, the developments in millifluidic devices for small model organisms are limited compared to other fields of biomicrofluidics. The main reasons for this stagnanation are difficulties in prototyping of millimeter scale and high aspect ratio devices needed for large metazoan organisms. Standard photolithography is in this context a time consuming procedure not easily adapted for fabrication of molds with vertical dimensions above 1 mm. Moreover, photolithography is still largely unattainable to a gross majority of biomedical laboratories willing to pursue custom development of their own chip-based platforms due to costs and need for dedicated clean room facilities. In this work, we present application of high-definition additive manufacturing systems for fabrication of 3D printed moulds used in soft lithography. Combination of 3D printing with PDMS replica molding appears to be an alternative for millifluidic systems that yields rapid and cost effective prototyping pipeline. We investigated the important aspects on both 3D printed moulds and PDMS replicas such as geometric accuracies and surface topology. Our results demonstrated that SLA technologies could be applied for rapid and accurate fabrication of millifluidic devices for trapping of millimetre-sized specimens such as living zebrafish larvae. We applied the new manufacturing method in a proof-of-concept prototype device capable of trapping and immobilizing living zebrafish larvae for recording heart rate variation in cardio-toxicity experiments.

  16. Wireless implantable chip with integrated nitinol-based pump for radio-controlled local drug delivery.

    Science.gov (United States)

    Fong, Jeffrey; Xiao, Zhiming; Takahata, Kenichi

    2015-02-21

    We demonstrate an active, implantable drug delivery device embedded with a microfluidic pump that is driven by a radio-controlled actuator for temporal drug delivery. The polyimide-packaged 10 × 10 × 2 mm(3) chip contains a micromachined pump chamber and check valves of Parylene C to force the release of the drug from a 76 μL reservoir by wirelessly activating the actuator using external radio-frequency (RF) electromagnetic fields. The rectangular-shaped spiral-coil actuator based on nitinol, a biocompatible shape-memory alloy, is developed to perform cantilever-like actuation for pumping operation. The nitinol-coil actuator itself forms a passive 185 MHz resonant circuit that serves as a self-heat source activated via RF power transfer to enable frequency-selective actuation and pumping. Experimental wireless operation of fabricated prototypes shows successful release of test agents from the devices placed in liquid and excited by radiating tuned RF fields with an output power of 1.1 W. These tests reveal a single release volume of 219 nL, suggesting a device's capacity of ~350 individual ejections of drug from its reservoir. The thermal behavior of the activated device is also reported in detail. This proof-of-concept prototype validates the effectiveness of wireless RF pumping for fully controlled, long-lasting drug delivery, a key step towards enabling patient-tailored, targeted local drug delivery through highly miniaturized implants.

  17. Chip-integrated optical power limiter based on an all-passive micro-ring resonator.

    Science.gov (United States)

    Yan, Siqi; Dong, Jianji; Zheng, Aoling; Zhang, Xinliang

    2014-10-20

    Recent progress in silicon nanophotonics has dramatically advanced the possible realization of large-scale on-chip optical interconnects integration. Adopting photons as information carriers can break the performance bottleneck of electronic integrated circuit such as serious thermal losses and poor process rates. However, in integrated photonics circuits, few reported work can impose an upper limit of optical power therefore prevent the optical device from harm caused by high power. In this study, we experimentally demonstrate a feasible integrated scheme based on a single all-passive micro-ring resonator to realize the optical power limitation which has a similar function of current limiting circuit in electronics. Besides, we analyze the performance of optical power limiter at various signal bit rates. The results show that the proposed device can limit the signal power effectively at a bit rate up to 20 Gbit/s without deteriorating the signal. Meanwhile, this ultra-compact silicon device can be completely compatible with the electronic technology (typically complementary metal-oxide semiconductor technology), which may pave the way of very large scale integrated photonic circuits for all-optical information processors and artificial intelligence systems.

  18. A programming environment to control switching networks based on STC104 packet routing chip

    Science.gov (United States)

    Legrand, I. C.; Schwendicke, U.; Leich, H.; Medinnis, M.; Koehler, A.; Wegner, P.; Sulanke, K.; Dippel, R.; Gellrich, A.

    1997-02-01

    The software environment used to control a large switching architecture based on SGS-Thomson STC104 (an asynchronous 32-way dynamic packet routing chip) is presented. We are evaluating this switching technology for large scale, real-time parallel systems. A Graphical User Interface (GUI) written as a multi-thread application in Java allows to set the switch configuration and to continuously monitor the state of each link. This GUI connects to a multi-thread server via TCP/IP sockets. The server is running on a PC-Linux system and implements the virtual channel protocol in communicating with the STC104 switching units using the Data Strobe link or the VME bus. Linux I/O drivers to control the Data Strobe link parallel adaptor (STC101) were developed. For each client the server creates a new thread and allocates a new socket for communications. The Java code of the GUI may be transferred to any client using the http protocol providing a user friendly interface to the system with real-time monitoring which is also platform independent.

  19. Lab-on-a-chip-based high-throughput screening of the genotoxicity of engineered nanomaterials.

    Science.gov (United States)

    Vecchio, Giuseppe; Fenech, Michael; Pompa, Pier Paolo; Voelcker, Nicolas H

    2014-07-09

    The continuous increasing of engineered nanomaterials (ENMs) in our environment, their combinatorial diversity, and the associated genotoxic risks, highlight the urgent need to better define the possible toxicological effects of ENMs. In this context, we present a new high-throughput screening (HTS) platform based on the cytokinesis-block micronucleus (CBMN) assay, lab-on-chip cell sorting, and automated image analysis. This HTS platform has been successfully applied to the evaluation of the cytotoxic and genotoxic effects of silver nanoparticles (AgNPs) and silica nanoparticles (SiO2NPs). In particular, our results demonstrate the high cyto- and genotoxicity induced by AgNPs and the biocompatibility of SiO2NPs, in primary human lymphocytes. Moreover, our data reveal that the toxic effects are also dependent on size, surface coating, and surface charge. Most importantly, our HTS platform shows that AgNP-induced genotoxicity is lymphocyte sub-type dependent and is particularly pronounced in CD2+ and CD4+ cells.

  20. Construction of a multidimensional plane network-on-chip architecture based on the hypercube structure

    Institute of Scientific and Technical Information of China (English)

    Chang Wu; Yubai Li; Qicong Peng; Song Chai; Zhongming Yang

    2009-01-01

    In current network-on-chip (NOC) studies and in practical applications,the mesh structure is the most widely used and deeply researched structure.However,the hypercube structure is more symmetrical and regular than the mesh or torus structures.This paper compares the network characteristics of these three direct topologies and proposes a method to compress the hypercube into a plane structure.This structure,which has the multidimensional property based on the hypercube,is called the multidimensional plane (MDP) NOC.The compression process is divided into two steps:the transformation of router denotations and the connection of channels.Then,SystemC is used to implement the MDP NOC and it is compared with the mesh and torus NOCs in terms of four aspects of performance,including average latency time,normalization throughput,energy consumption and area cost.(C) 2008 National Natural Science Foundation of China and Chinese Academy of Sciences.Published by Elsevier Limited and Science in China Press.All rights reserved.

  1. On-chip native gel electrophoresis-based immunoassays for tetanus antibody and toxin.

    Science.gov (United States)

    Herr, Amy E; Throckmorton, Daniel J; Davenport, Andrew A; Singh, Anup K

    2005-01-15

    By integrating photopolymerized cross-linked polyacrylamide gels within a microfluidic device, we have developed a microanalytical platform for performing electrophoresis-based immunoassays. The microfluidic immunoassays are performed by gel electrophoretic separation and quantitation of bound and unbound antibody or antigen. To retain biological activity of proteins and maintain intact immune complexes, nondenaturing polyacrylamide gel electrophoresis conditions were investigated. Both direct (noncompetitive) and competitive immunoassay formats are demonstrated in microchips. A direct immunoassay was developed for detection of tetanus antibodies in buffer as well as diluted serum samples. After an off-chip incubation step, the immunoassay was completed in less than 3 min and the sigmoidal dose-response curve spanned an antibody concentration range from 0.17 to 260 nM. The minimum detectable antibody concentration was 0.68 nM. A competitive immunoassay was also developed for tetanus toxin C-fragment by allowing unlabeled and fluorescently labeled tetanus toxin C-fragment compete to bind to a limited fixed concentration of tetanus antibody. The immunoassay technique described in this work shows promise as a component of an integrated microfluidic device amenable to automation and relevant to development of clinical diagnostic devices.

  2. Chip-integrated optical power limiter based on an all-passive micro-ring resonator

    Science.gov (United States)

    Yan, Siqi; Dong, Jianji; Zheng, Aoling; Zhang, Xinliang

    2014-10-01

    Recent progress in silicon nanophotonics has dramatically advanced the possible realization of large-scale on-chip optical interconnects integration. Adopting photons as information carriers can break the performance bottleneck of electronic integrated circuit such as serious thermal losses and poor process rates. However, in integrated photonics circuits, few reported work can impose an upper limit of optical power therefore prevent the optical device from harm caused by high power. In this study, we experimentally demonstrate a feasible integrated scheme based on a single all-passive micro-ring resonator to realize the optical power limitation which has a similar function of current limiting circuit in electronics. Besides, we analyze the performance of optical power limiter at various signal bit rates. The results show that the proposed device can limit the signal power effectively at a bit rate up to 20 Gbit/s without deteriorating the signal. Meanwhile, this ultra-compact silicon device can be completely compatible with the electronic technology (typically complementary metal-oxide semiconductor technology), which may pave the way of very large scale integrated photonic circuits for all-optical information processors and artificial intelligence systems.

  3. System on chip thermal vacuum sensor based on standard CMOS process

    Institute of Scientific and Technical Information of China (English)

    Li Jinfeng; Tang Zhen'an; Wang Jiaqi

    2009-01-01

    An on-chip microelectromechanical system was fabricated in a 0.5μm standard CMOS process for gas pressure detection. The sensor was based on a micro-hotplate (MHP) and had been integrated with a rail to rail operational amplifier and an 8-bit successive approximation register (SAR) A/D converter. A tungsten resistor was manufactured on the MHP as the sensing element, and the sacrificial layer of the sensor was made from polysilicon and etched by surface-micromachining technology. The operational amplifier was configured to make the sensor operate in constant current mode. A digital bit stream was provided as the system output. The measurement results demonstrate that the gas pressure sensitive range of the vacuum sensor extends from 1 to 105 Pa. In the gas pressure range from 1 to 100 Pa, the sensitivity of the sensor is 0.23 mV/Pa, the linearity is 4.95%, and the hysteresis is 8.69%. The operational amplifier can drive 200 Ω resistors distortionlessly, and the SAR A/D converter achieves a resolution of 7.4 bit with 100 kHz sample rate. The performance of the operational amplifier and the SAR A/D converter meets the requirements of the sensor system.

  4. Gate-based decomposition of index generation functions

    Science.gov (United States)

    Łuba, Tadeusz; Borowik, Grzegorz; Jankowski, Cezary

    2016-09-01

    Index Generation Functions may be useful in distribution of IP addresses, virus scanning, or undesired data detection. Traditional approach leads to universal cells based decomposition. In this paper an original method is proposed. The proposed multilevel logic synthesis method based on functional decomposition uses gates instead of cells. Furthermore, it preserves advantages of functional decomposition and is well suited for ROM-based synthesis of Index Generation Functions.

  5. Compact 0.3-to-1.125 GHz self-biased phase-locked loop for system-on-chip clock generation in 0.18 µm CMOS

    Science.gov (United States)

    Zhang, Zhao; Liu, Liyuan; Feng, Peng; Liu, Jian; Wu, Nanjian

    2016-04-01

    In this paper, we propose a compact ring-oscillator-based self-biased phase-locked loop (SBPLL) for system-on-chip (SoC) clock generation. It adopts the proposed triple-well NMOS source degeneration voltage-to-current (V-I) converter instead of the operational amplifier (OPAMP) based V-I converter and a proposed simple start-up circuit with a negligible area to save power and area. The SBPLL is implemented in the 0.18 µm CMOS process, and it occupies 0.048 mm2 active core. The measurement results show the SBPLL can generate output frequency in a wide range from 300 MHz to 1.125 GHz with a constant loop bandwidth that is around 5 MHz and a relatively low jitter performance that is less than 4.9 mUI over the entire covered frequency range. From -20 to 70 °C the rms jitter variation and loop bandwidth variation at 1.125 GHz are 0.2 ps and 350 kHz, respectively. The rms jitter performance variation of all covered frequency points is less than 10% in the supply range from 1.5 to 1.7 V. Such SBPLL shows robustness over environmental variation. The maximum power consumption is 5.6 mW with 1.6 V supply at an output frequency of 1.125 GHz.

  6. An Algorithm on Generating Lattice Based on Layered Concept Lattice

    Directory of Open Access Journals (Sweden)

    Zhang Chang-sheng

    2013-08-01

    Full Text Available Concept lattice is an effective tool for data analysis and rule extraction, a bottleneck factor on impacting the applications of concept lattice is how to generate lattice efficiently. In this paper, an algorithm LCLG on generating lattice in batch processing based on layered concept lattice is developed, this algorithm is based on layered concept lattice, the lattice is generated downward layer by layer through concept nodes and provisional nodes in current layer; the concept nodes are found parent-child relationships upward layer by layer, then the Hasse diagram of inter-layer connection is generated; in the generated process of the lattice nodes in each layer, we do the pruning operations dynamically according to relevant properties, and delete some unnecessary nodes, such that the generating speed is improved greatly; the experimental results demonstrate that the proposed algorithm has good performance.

  7. Chip-Scale Bioassays Based on Surface-Enhanced Raman Scattering: Fundamentals and Applications

    Energy Technology Data Exchange (ETDEWEB)

    Hye-Young Park

    2005-12-17

    This work explores the development and application of chip-scale bioassays based on surface-enhanced Raman scattering (SERS) for high throughput and high sensitivity analysis of biomolecules. The size effect of gold nanoparticles on the intensity of SERS is first presented. A sandwich immunoassay was performed using Raman-labeled immunogold nanoparticles with various sizes. The SERS responses were correlated to particle densities, which were obtained by atomic force microscopy (AFM). The response of individual particles was also investigated using Raman-microscope and an array of gold islands on a silicon substrate. The location and the size of individual particles were mapped using AFM. The next study describes a low-level detection of Escherichia coli 0157:H7 and simulants of biological warfare agents in a sandwich immunoassay format using SERS labels, which have been termed Extrinsic Raman labels (ERLs). A new ERL scheme based on a mixed monolayer is also introduced. The mixed monolayer ERLs were created by covering the gold nanoparticles with a mixture of two thiolates, one thiolate for covalently binding antibody to the particle and the other thiolate for producing a strong Raman signal. An assay platform based on mixed self-assembled monolayers (SAMs) on gold is then presented. The mixed SAMs were prepared from dithiobis(succinimidyl undecanoate) (DSU) to covalently bind antibodies on gold substrate and oligo(ethylene glycol)-terminated thiol to prevent nonspecific adsorption of antibodies. After the mixed SAMs surfaces, formed from various mole fraction of DSU were incubated with antibodies, AFM was used to image individual antibodies on the surface. The final study presents a collaborative work on the single molecule adsorption of YOYO-I labeled {lambda}-DNA at compositionally patterned SAMs using total internal reflection fluorescence microscopy. The role of solution pH, {lambda}-DNA concentration, and domain size was investigated. This work also revealed

  8. Chip-Scale Bioassays Based on Surface-Enhanced Raman Scattering: Fundamentals and Applications

    Energy Technology Data Exchange (ETDEWEB)

    Park, Hye-Young [Iowa State Univ., Ames, IA (United States)

    2005-01-01

    This work explores the development and application of chip-scale bioassays based on surface-enhanced Raman scattering (SERS) for high throughput and high sensitivity analysis of biomolecules. The size effect of gold nanoparticles on the intensity of SERS is first presented. A sandwich immunoassay was performed using Raman-labeled immunogold nanoparticles with various sizes. The SERS responses were correlated to particle densities, which were obtained by atomic force microscopy (AFM). The response of individual particles was also investigated using Raman-microscope and an array of gold islands on a silicon substrate. The location and the size of individual particles were mapped using AFM. The next study describes a low-level detection of Escherichia coli 0157:H7 and simulants of biological warfare agents in a sandwich immunoassay format using SERS labels, which have been termed Extrinsic Raman labels (ERLs). A new ERL scheme based on a mixed monolayer is also introduced. The mixed monolayer ERLs were created by covering the gold nanoparticles with a mixture of two thiolates, one thiolate for covalently binding antibody to the particle and the other thiolate for producing a strong Raman signal. An assay platform based on mixed self-assembled monolayers (SAMs) on gold is then presented. The mixed SAMs were prepared from dithiobis(succinimidyl undecanoate) (DSU) to covalently bind antibodies on gold substrate and oligo(ethylene glycol)-terminated thiol to prevent nonspecific adsorption of antibodies. After the mixed SAMs surfaces, formed from various mole fraction of DSU were incubated with antibodies, AFM was used to image individual antibodies on the surface. The final study presents a collaborative work on the single molecule adsorption of YOYO-I labeled {lambda}-DNA at compositionally patterned SAMs using total internal reflection fluorescence microscopy. The role of solution pH, {lambda}-DNA concentration, and domain size was investigated. This work also revealed

  9. Generating Weather Forecast Texts with Case Based Reasoning

    OpenAIRE

    Adeyanju, Ibrahim

    2015-01-01

    Several techniques have been used to generate weather forecast texts. In this paper, case based reasoning (CBR) is proposed for weather forecast text generation because similar weather conditions occur over time and should have similar forecast texts. CBR-METEO, a system for generating weather forecast texts was developed using a generic framework (jCOLIBRI) which provides modules for the standard components of the CBR architecture. The advantage in a CBR approach is that systems can be built...

  10. [Design of Electrocardiogram Signal Generator Based on Typical Electrocardiogram Database].

    Science.gov (United States)

    Wang, Yuting; Wang, Xiaofei; Li, Dongshang; Liu, Guili

    2016-02-01

    Using LabVIEW programming and high-speed multifunction data acquisition card PCI-6251, we designed an electrocardiogram (ECG) signal generator based on Chinese typical ECG database. When the ECG signals are given off by the generator, the generator can also display the ECG information annotations at the same time, including waveform data and diagnostic results. It could be a useful assisting tool of ECG automatic diagnose instruments.

  11. Add-Drop Filter Based on Wavelength-Dependent Light Interlink between Lithium-Niobate Microwaveguide Chip and Microfiber Knot Ring

    Directory of Open Access Journals (Sweden)

    Suxu Zhou

    2016-06-01

    Full Text Available In this paper, we experimentally demonstrate an add-drop filter based on wavelength-dependent light coupling between a lithium-niobate (LN microwaveguide chip and a microfiber knot ring (MKR. The MKR was fabricated from a standard single-mode fiber, and the LN microwaveguide chip works as a robust substrate to support the MKR. The guided light can be transmitted through add and drop functionality and the behaviors of the add-drop filter can be clearly observed. Furthermore, its performance dependence on the MKR diameter is also studied experimentally. The approach, using a LN microwaveguide chip as a platform to couple and integrate the MKR, may enable us to realize an optical interlink between the microstructured chip and the micro/nano fiber-optic device.

  12. Off surface matrix based on-chip electrochemical biosensor platform for protein biomarker detection in undiluted serum.

    Science.gov (United States)

    Arya, Sunil K; Kongsuphol, Patthara; Park, Mi Kyoung

    2017-06-15

    The manuscript describes a concept of using off surface matrix modified with capturing biomolecule for on-chip electrochemical biosensing. 3D matrix made by laser engraving of polymethyl methacrylate (PMMA) sheet as off surface matrix was integrated in very close vicinity of the electrode surface. Laser engraving and holes in PMMA along with spacing from surface provide fluidic channel and incubation chamber. Covalent binding of capturing biomolecule (anti-TNF-α antibody) on off-surface matrix was achieved via azide group activity of 4-fluoro-3-nitro-azidobenzene (FNAB), which act as cross-linker and further covalently binds to anti-TNF-α antibody via thermal reaction. Anti-TNF-α/FNAB/PMMA matrix was then integrated over comb structured gold electrode array based sensor chip. Separate surface modification followed by integration of sensor helped to prevent the sensor chip surface from fouling during functionalization. Nonspecific binding was prevented using starting block T20 (PBS). Results for estimating protein biomarker (TNF-α) in undiluted serum using Anti-TNF-α/FNAB/PMMA/Au reveal that system can detect TNF-α in 100pg/ml to 100ng/ml range with high sensitivity of 119nA/(ng/ml), with negligible interference from serum proteins and other cytokines. Thus, use of off surface matrix may provide the opportunity to electrochemically sense biomarkers sensitively to ng/ml range with negligible nonspecific binding and false signal in undiluted serum.

  13. Experimental determination of the nucleation rates of undercooled micron-sized liquid droplets based on fast chip calorimetry

    Energy Technology Data Exchange (ETDEWEB)

    Simon, Christian, E-mail: ch.simon@uni-muenster.de; Peterlechner, Martin; Wilde, Gerhard

    2015-03-10

    Highlights: • Fast scanning calorimeter calibration with position dependence. • Calibration of fast scanning calorimeter during cooling. • Quantitative determination of nucleation rates by treating the undercooling as stochastic parameter - Abstract: Accurate thermal analyzes and calorimetry measurements depend on careful calibration measurements. For conventional differential scanning calorimeters (DSC) the calibration procedure is well known. The melting point of different pure metals is measured and compared with literature data to adjust the temperature reading of the calorimeter. Likewise, the measured melting enthalpies of standard reference substances serve for enthalpy calibration. Yet for fast chip calorimetry, new procedures need to be established. For the medium-area and large-area calorimeter chips, this procedure needs to be modified, because the calibration behavior depends on the position of the sample on the measurement area. Additionally, a way to calibrate the calorimeter for measurements performed during cooling will also be shown. For this second aspect, the athermal and diffusionless martensitic phase transformation of Ni{sub 49.9}–Ti{sub 50.1} at% was used. The well-calibrated sensor chips are ideally suited to perform nucleation rate density analyzes based on a statistical approach. Here, the nucleation rate densities of micron-sized pure Sn droplets that had been coated with a non-catalytic coating have been determined by experimental analysis of the statistical variance of the undercooling response.

  14. S-Mesh: a Mesh-based on-chip network with separation of control and transmission

    Institute of Scientific and Technical Information of China (English)

    LIU Hao; ZOU Xue-cheng; JI Li-xin; CAI Meng; ZHANG Ke-feng

    2009-01-01

    The current network-on-chip (NoC) topology cannot predict subsequent switch node status promptly. Switch nodes have to perform various functions such as routing decision, data forwarding, packet buffering, congestion control and properties of an NoC system. Therefore, these make switch architecture far more complex. This article puts forward a separating on-chip network architecture based on Mesh (S-Mesh). S-Mesh is an on-chip network that separates routing decision flow from the switches. It consists of two types of networks: datapath network (DN) and control network (CN). The CN establishes data paths for data transferring in DN. Meanwhile, the CN also transfers instructions between different resources. This property makes switch architecture simple, and eliminates conflicts in network interface units between the resource and switch. Compared with 2D-Mesh, Torus Mesh, Fat-tree and Butterfly, the average packet latency in S-Mesh is the shortest when the packet length is more than 53 B. Compared with 2D-Mesh, the areas savings of S-Mesh is about 3%--7%, and the power dissipation is decreased by approximate 2%.

  15. Design of a current based readout chip and development of a DEPFET pixel prototype system for the ILC vertex detector

    Energy Technology Data Exchange (ETDEWEB)

    Trimpl, M.

    2005-12-15

    The future TeV-scale linear collider ILC (International Linear Collider) offers a large variety of precision measurements complementary to the discovery potential of the LHC (Large Hadron Collider). To fully exploit its physics potential, a vertex detector with unprecedented performance is needed. One proposed technology for the ILC vertex detector is the DEPFET active pixel sensor. The DEPFET sensor offers particle detection with in-pixel amplification by incorporating a field effect transistor into a fully depleted high-ohmic silicon substrate. The device provides an excellent signal-to-noise ratio and a good spatial resolution at the same time. To establish a very fast readout of a DEPFET pixel matrix with row rates of 20 MHz and more, the 128 channel CURO II ASIC has been designed and fabricated. The architecture of the chip is completely based on current mode techniques (SI) perfectly adapted to the current signal of the sensor. For the ILC vertex detector a prototype system with a 64 x 128 DEPFET pixel matrix read out by the CURO II chip has been developed. The design issues and the standalone performance of the readout chip as well as first results with the prototype system will be presented. (orig.)

  16. Coupling paper-based microfluidics and lab on a chip technologies for confirmatory analysis of trinitro aromatic explosives.

    Science.gov (United States)

    Pesenti, Alessandra; Taudte, Regina Verena; McCord, Bruce; Doble, Philip; Roux, Claude; Blanes, Lucas

    2014-05-20

    A new microfluidic paper-based analytical device (μPAD) in conjunction with confirmation by a lab on chip analysis was developed for detection of three trinitro aromatic explosives. Potassium hydroxide was deposited on the μPADs (0.5 μL, 1.5 M), creating a color change reaction when explosives are present, with detection limits of approximately 7.5 ± 1.0 ng for TNB, 12.5 ± 2.0 ng for TNT and 15.0 ± 2.0 ng for tetryl. For confirmatory analysis, positive μPADs were sampled using a 5 mm hole-punch, followed by extraction of explosives from the punched chad in 30 s using 20 μL borate/SDS buffer. The extractions had efficiencies of 96.5 ± 1.7%. The extracted explosives were then analyzed with the Agilent 2100 Bioanalyzer lab on a chip device with minimum detectable amounts of 3.8 ± 0.1 ng for TNB, 7.0 ± 0.9 ng for TNT, and 4.7 ± 0.2 ng for tetryl. A simulated in-field scenario demonstrated the feasibility of coupling the μPAD technique with the lab on a chip device to detect and identify 1 μg of explosives distributed on a surface of 100 cm(2).

  17. Protein functionalized carbon nanotubes-based smart lab-on-a-chip.

    Science.gov (United States)

    Ali, Md Azahar; Solanki, Pratima R; Srivastava, Saurabh; Singh, Samer; Agrawal, Ved V; John, Renu; Malhotra, Bansi D

    2015-03-18

    A label-free impedimetric lab on a chip (iLOC) is fabricated using protein (bovine serum albumin) and antiapolipoprotein B functionalized carbon nanotubes-nickel oxide (CNT-NiO) nanocomposite for low-density lipoprotein (LDL) detection. The antiapolipoprotein B (AAB) functionalized CNT-NiO microfluidic electrode is assembled with polydimethylsiloxane rectangular microchannels (cross section: 100 × 100 μm). Cytotoxicity of the synthesized CNTs, NiO nanoparticles, and CNT-NiO nanocomposite has been investigated in the presence of lung epithelial cancer A549 cell line using MTT assay. The CNT-NiO nanocomposite shows higher cell viability at a concentration of 6.5 μg/mL compared to those using individual CNTs. The cell viability and proliferation studies reveal that the toxicity increases with increasing CNTs concentration. The X-ray photoelectron spectroscopy studies have been used to quantify the functional groups present on the CNT-NiO electrode surface before and after proteins functionalization. The binding kinetic and electrochemical activities of CNT-NiO based iLOC have been conducted using chronocoulometry and impedance spectroscopic techniques. This iLOC shows excellent sensitivity of 5.37 kΩ (mg/dL)(-1) and a low detection limit of 0.63 mg/dL in a wide concentration range (5-120 mg/dL) of LDL. The binding kinetics of antigen-antibody interaction of LDL molecules reveal a high association rate constant (8.13 M(-1) s(-1)). Thus, this smart nanocomposite (CNT-NiO) based iLOC has improved stability and reproducibility and has implications toward in vivo diagnostics.

  18. Lab on a chip genotyping for Brucella spp. based on 15-loci multi locus VNTR analysis

    Directory of Open Access Journals (Sweden)

    Marianelli Cinzia

    2009-04-01

    Full Text Available Abstract Background Brucellosis is an important zoonosis caused by the genus Brucella. In addition Brucella represents potential biological warfare agents due to the high contagious rates for humans and animals. Therefore, the strain typing epidemiological tool may be crucial for tracing back source of infection in outbreaks and discriminating naturally occurring outbreaks versus bioterroristic event. A Multiple Locus Variable-number tandem repeats (VNTR Analysis (MLVA assay based on 15 polymorphic markers was previously described. The obtained MLVA band profiles may be resolved by techniques ranging from low cost manual agarose gels to the more expensive capillary electrophoresis sequencing. In this paper a rapid, accurate and reproducible system, based on the Lab on a chip technology was set up for Brucella spp. genotyping. Results Seventeen DNA samples of Brucella strains isolated in Sicily, previously genotyped, and twelve DNA samples, provided by MLVA Brucella VNTR ring trial, were analyzed by MLVA-15 on Agilent 2100. The DNA fragment sizes produced by Agilent, compared with those expected, showed discrepancies; therefore, in order to assign the correct alleles to the Agilent DNA fragment sizes, a conversion table was produced. In order to validate the system twelve unknown DNA samples were analyzed by this method obtaining a full concordance with the VNTR ring trial results. Conclusion In this paper we described a rapid and specific detection method for the characterization of Brucella isolates. The comparison of the MLVA typing data produced by Agilent system with the data obtained by standard sequencing or ethidium bromide slab gel electrophoresis showed a general concordance of the results. Therefore this platform represents a fair compromise among costs, speed and specificity compared to any conventional molecular typing technique.

  19. An Integrated Circuit for Chip-Based Analysis of Enzyme Kinetics and Metabolite Quantification.

    Science.gov (United States)

    Cheah, Boon Chong; Macdonald, Alasdair Iain; Martin, Christopher; Streklas, Angelos J; Campbell, Gordon; Al-Rawhani, Mohammed A; Nemeth, Balazs; Grant, James P; Barrett, Michael P; Cumming, David R S

    2016-06-01

    We have created a novel chip-based diagnostic tools based upon quantification of metabolites using enzymes specific for their chemical conversion. Using this device we show for the first time that a solid-state circuit can be used to measure enzyme kinetics and calculate the Michaelis-Menten constant. Substrate concentration dependency of enzyme reaction rates is central to this aim. Ion-sensitive field effect transistors (ISFET) are excellent transducers for biosensing applications that are reliant upon enzyme assays, especially since they can be fabricated using mainstream microelectronics technology to ensure low unit cost, mass-manufacture, scaling to make many sensors and straightforward miniaturisation for use in point-of-care devices. Here, we describe an integrated ISFET array comprising 2(16) sensors. The device was fabricated with a complementary metal oxide semiconductor (CMOS) process. Unlike traditional CMOS ISFET sensors that use the Si3N4 passivation of the foundry for ion detection, the device reported here was processed with a layer of Ta2O5 that increased the detection sensitivity to 45 mV/pH unit at the sensor readout. The drift was reduced to 0.8 mV/hour with a linear pH response between pH 2-12. A high-speed instrumentation system capable of acquiring nearly 500 fps was developed to stream out the data. The device was then used to measure glucose concentration through the activity of hexokinase in the range of 0.05 mM-231 mM, encompassing glucose's physiological range in blood. Localised and temporal enzyme kinetics of hexokinase was studied in detail. These results present a roadmap towards a viable personal metabolome machine.

  20. A Robust Quantum Random Number Generator Based on Bosonic Stimulation

    CERN Document Server

    H, Akshata Shenoy; Srikanth, R; Srinivas, T

    2011-01-01

    We propose a method to realize a robust quantum random number generator based on bosonic stimulation. A particular implementation that employs weak coherent pulses and conventional avalanche photo-diode detectors (APDs) is discussed.

  1. Design of a CMOS-based multichannel integrated biosensor chip for bioelectronic interface with neurons.

    Science.gov (United States)

    Zhang, Xin; Wong, Wai Man; Zhang, Yulong; Zhang, Yandong; Gao, Fei; Nelson, Richard D; Larue, John C

    2009-01-01

    In this paper we present the design and prototyping of a 24-channel mixed signal full-customized CMOS integrated biosensor chip for in vitro extracellular recording of neural signals. Design and implementation of hierarchical modules including microelectrode electrophysiological sensors, analog signal buffers, high gain amplifier and control/interface units are presented in detail. The prototype chip was fabricated by MOSIS with AMI C5 0.5 microm, double poly, triple metal layer CMOS technology. The electroless gold plating process is used to replace the aluminum material obtained from the standard CMOS process with biocompatible metal gold in the planner microelectrode array sensors to prevent cell poisoning and undesirable electrochemical corrosion. The biosensor chip provides a satisfactory signal-to-noise ratio for neural signals with amplitudes and frequencies within the range of 600microV - 2mV and 100 Hz to 10KHz, respectively.

  2. Multi-band local microwave signal generation based on an optical frequency comb generator

    Science.gov (United States)

    Wang, Wen Ting; Liu, Jian Guo; Sun, Wen Hui; Chen, Wei; Zhu, Ning Hua

    2015-03-01

    We propose and experimental demonstrate a new method to generate multi-band local microwave signals based on an optical frequency comb generator (OFCG) by applying an optical sideband injection locking technique and an optical heterodyning technique. The generated microwave signal can cover multi bands from S band to Ka band. A tunable multiband microwave signal spanning from 5 GHz to 40 GHz can be generated by the beating between the optical carrier and injection locked modulation sidebands in a photodetector without an optical filter. The wavelength of the slave laser can be continuously and near-linearly adjusted by proper changing its bias current. By tuning the bias current of the slave laser, the wavelength of that is matched to one of the modulation sidebands of the OFCG. The performance of the arrangement in terms of the tunability and stability of the generated microwave signal is also studied.

  3. Dynamic Frames Based Generation of 3D Scenes and Applications

    OpenAIRE

    Kvesić, Anton; Radošević, Danijel; Orehovački, Tihomir

    2015-01-01

    Modern graphic/programming tools like Unity enables the possibility of creating 3D scenes as well as making 3D scene based program applications, including full physical model, motion, sounds, lightning effects etc. This paper deals with the usage of dynamic frames based generator in the automatic generation of 3D scene and related source code. The suggested model enables the possibility to specify features of the 3D scene in a form of textual specification, as well as exporting such features ...

  4. Photonic chip based transmitter optimization and receiver demultiplexing of a 1.28 Tbit/s OTDM signal

    DEFF Research Database (Denmark)

    Vo, T.D.; Hu, Hao; Galili, Michael;

    2010-01-01

    We demonstrate chip-based Tbaud optical signal processing for all-optical performance monitoring, switching and demultiplexing based on the instantaneous Kerr nonlinearity in a dispersion-engineered As_2S_3 planar waveguide. At the Tbaud transmitter, we use a THz bandwidth radio-frequency spectrum...... analyzer to perform all-optical performance monitoring and to optimize the optical time division multiplexing stages as well as mitigate impairments, for example, dispersion. At the Tbaud receiver, we demonstrate error-free demultiplexing of a 1.28 Tbit/s single wavelength, return-to-zero signal to 10 Gbit...

  5. A Methodology for Platform Based High—Level System—on—Chip Verification

    Institute of Scientific and Technical Information of China (English)

    GAOFeng; LIUPeng; YAOQingdong

    2003-01-01

    The time-to-market challenge has increased the need for shortening the co-verification time in system-on-chip development.In this article,a new methodology of high-level hardware/software coverification is introduced.With the help of the real-time operating system,the application program can easily be migrated from the software simulator to the hardware emulation board.The hierarchical architecture can be used to separate application program from the implementation of the platform during the veriflaction process.The highlevel verification platform is successfully used in developing the HDTV decoding chip.

  6. Corrugated Textile based Triboelectric Generator for Wearable Energy Harvesting

    Science.gov (United States)

    Choi, A Young; Lee, Chang Jun; Park, Jiwon; Kim, Dogyun; Kim, Youn Tae

    2017-01-01

    Triboelectric energy harvesting has been applied to various fields, from large-scale power generation to small electronics. Triboelectric energy is generated when certain materials come into frictional contact, e.g., static electricity from rubbing a shoe on a carpet. In particular, textile-based triboelectric energy-harvesting technologies are one of the most promising approaches because they are not only flexible, light, and comfortable but also wearable. Most previous textile-based triboelectric generators (TEGs) generate energy by vertically pressing and rubbing something. However, we propose a corrugated textile-based triboelectric generator (CT-TEG) that can generate energy by stretching. Moreover, the CT-TEG is sewn into a corrugated structure that contains an effective air gap without additional spacers. The resulting CT-TEG can generate considerable energy from various deformations, not only by pressing and rubbing but also by stretching. The maximum output performances of the CT-TEG can reach up to 28.13 V and 2.71 μA with stretching and releasing motions. Additionally, we demonstrate the generation of sufficient energy from various activities of a human body to power about 54 LEDs. These results demonstrate the potential application of CT-TEGs for self-powered systems.

  7. Preserving Differential Privacy in Degree-Correlation based Graph Generation.

    Science.gov (United States)

    Wang, Yue; Wu, Xintao

    2013-08-01

    Enabling accurate analysis of social network data while preserving differential privacy has been challenging since graph features such as cluster coefficient often have high sensitivity, which is different from traditional aggregate functions (e.g., count and sum) on tabular data. In this paper, we study the problem of enforcing edge differential privacy in graph generation. The idea is to enforce differential privacy on graph model parameters learned from the original network and then generate the graphs for releasing using the graph model with the private parameters. In particular, we develop a differential privacy preserving graph generator based on the dK-graph generation model. We first derive from the original graph various parameters (i.e., degree correlations) used in the dK-graph model, then enforce edge differential privacy on the learned parameters, and finally use the dK-graph model with the perturbed parameters to generate graphs. For the 2K-graph model, we enforce the edge differential privacy by calibrating noise based on the smooth sensitivity, rather than the global sensitivity. By doing this, we achieve the strict differential privacy guarantee with smaller magnitude noise. We conduct experiments on four real networks and compare the performance of our private dK-graph models with the stochastic Kronecker graph generation model in terms of utility and privacy tradeoff. Empirical evaluations show the developed private dK-graph generation models significantly outperform the approach based on the stochastic Kronecker generation model.

  8. Loss Minimizing Operation of Doubly Fed Induction Generator Based Wind Generation Systems Considering Reactive Power Provision

    DEFF Research Database (Denmark)

    Baohua, Zhang; Hu, Weihao; Chen, Zhe

    2014-01-01

    The paper deals with control techniques for minimizing the operating loss of doubly fed induction generator based wind generation systems when providing reactive power. The proposed method achieves its goal through controlling the rotor side q-axis current in the synchronous reference frame....... The formula for the control reference is explicitly deduced in this paper considering the losses of the generator, the power electronic devices and the filter. Three control strategies are compared with the proposed method under different wind speeds and different reactive power references. The simulation...

  9. PERFORMANCE ENHANCED ROUTER DESIGN FOR NETWORK ON CHIP

    Directory of Open Access Journals (Sweden)

    Anbu chozhan.P

    2013-04-01

    Full Text Available Network on chip is a new paradigm for on chip design that is able to sustain the communication provisions for the SoC with the desired performance. NOC applies networking methodology concepts to system on chip data transfer and it gives noticeable elevation over conventionalbus based communication. NOC router is the backbone of on chip communication which directs the flow of data. In NOC router the arbiter is used during number of inputs request for the similar out port. Arbiter generates the grant based on the priority and previous granted input. For NOC router we have design the efficient round robin arbiter and analyse the power and area. In this paper on chip router is designed with a buffering technique of FWFT based asynchronous FIFO which improves timing and reduce power consumption. The proposed design of router is simulated and synthesized in Xilinx ISE 13.2 and the source code is written in Verilog. Cadence soc encounter of technology ami035 is used to generate layout of router and RTL compiler is used to compute area, power and timing.

  10. Data Generators for Learning Systems Based on RBF Networks.

    Science.gov (United States)

    Robnik-Sikonja, Marko

    2016-05-01

    There are plenty of problems where the data available is scarce and expensive. We propose a generator of semiartificial data with similar properties to the original data, which enables the development and testing of different data mining algorithms and the optimization of their parameters. The generated data allow large-scale experimentation and simulations without danger of overfitting. The proposed generator is based on radial basis function networks, which learn sets of Gaussian kernels. These Gaussian kernels can be used in a generative mode to generate new data from the same distributions. To assess the quality of the generated data, we evaluated the statistical properties of the generated data, structural similarity, and predictive similarity using supervised and unsupervised learning techniques. To determine usability of the proposed generator we conducted a large scale evaluation using 51 data sets. The results show a considerable similarity between the original and generated data and indicate that the method can be useful in several development and simulation scenarios. We analyze possible improvements in the classification performance by adding different amounts of the generated data to the training set, performance on high-dimensional data sets, and conditions when the proposed approach is successful.

  11. Cell Monitoring and Manipulation Systems (CMMSs based on Glass Cell-Culture Chips (GC3s

    Directory of Open Access Journals (Sweden)

    Sebastian M. Buehler

    2016-06-01

    Full Text Available We developed different types of glass cell-culture chips (GC3s for culturing cells for microscopic observation in open media-containing troughs or in microfluidic structures. Platinum sensor and manipulation structures were used to monitor physiological parameters and to allocate and permeabilize cells. Electro-thermal micro pumps distributed chemical compounds in the microfluidic systems. The integrated temperature sensors showed a linear, Pt1000-like behavior. Cell adhesion and proliferation were monitored using interdigitated electrode structures (IDESs. The cell-doubling times of primary murine embryonic neuronal cells (PNCs were determined based on the IDES capacitance-peak shifts. The electrical activity of PNC networks was detected using multi-electrode arrays (MEAs. During seeding, the cells were dielectrophoretically allocated to individual MEAs to improve network structures. MEA pads with diameters of 15, 20, 25, and 35 µm were tested. After 3 weeks, the magnitudes of the determined action potentials were highest for pads of 25 µm in diameter and did not differ when the inter-pad distances were 100 or 170 µm. Using 25-µm diameter circular oxygen electrodes, the signal currents in the cell-culture media were found to range from approximately −0.08 nA (0% O2 to −2.35 nA (21% O2. It was observed that 60-nm thick silicon nitride-sensor layers were stable potentiometric pH sensors under cell-culture conditions for periods of days. Their sensitivity between pH 5 and 9 was as high as 45 mV per pH step. We concluded that sensorized GC3s are potential animal replacement systems for purposes such as toxicity pre-screening. For example, the effect of mefloquine, a medication used to treat malaria, on the electrical activity of neuronal cells was determined in this study using a GC3 system.

  12. Quantitation of Cotinine in Nonsmoker Saliva Using Chip Based Nanoelectrospray Tandem Mass Spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Tomkins, Bruce A [ORNL; Van Berkel, Gary J [ORNL; Jenkins, Roger A [ORNL; Counts, Richard Wayne [ORNL

    2006-01-01

    A new analytical procedure was developed for the quantitation of nonsmoker salivary cotinine. Small volumes of saliva were diluted with water, fortified with cotinine-d{sub 3} (internal standard), then passed through small extraction columns. The analyte and internal standard were eluted with 0.1% (v/v) acetic acid/acetonitrile. Aliquots of each extract were analyzed directly, without chromatographic separation, using chip-based (NanoMate{sup TM}) nanospray tandem mass spectrometry. The calculated detection limit was 0.49 ng cotinine/mL saliva. This method was used to quantify salivary cotinine collected from nonsmoking human subjects living in one of three environmental tobacco smoke (ETS) exposure categories or 'cells': 1. smoking home/smoking workplace; 2. smoking home/nonsmoking workplace; and 3. nonsmoking home/smoking workplace. Samples were collected during five sequential days, including Saturday, as part of a larger study to evaluate potential variability in exposure to ETS. Salivary cotinine measurements were made for the purpose of excluding misclassified smokers and for comparison with known levels of exposure to airborne nicotine in each exposure category. The concentrations observed were consistent with those reported from other large studies reported elsewhere. A non-parametric statistical test was applied to the data within each cell. No statistically significant differences were found between the mean cotinine concentrations collected on a weekday as compared to those collected on a weekend day. When the non-parametric test was applied to the three cells, a statistically significant difference was observed between cell 1 compared to cells 2 and 3. The salivary cotinine concentrations were thus statistically invariant over a five-day exposure period, and they were greatest under the conditions of smoking home and smoking workplace.

  13. Human cell chips: adapting DNA microarray spotting technology to cell-based imaging assays.

    Science.gov (United States)

    Hart, Traver; Zhao, Alice; Garg, Ankit; Bolusani, Swetha; Marcotte, Edward M

    2009-10-28

    Here we describe human spotted cell chips, a technology for determining cellular state across arrays of cells subjected to chemical or genetic perturbation. Cells are grown and treated under standard tissue culture conditions before being fixed and printed onto replicate glass slides, effectively decoupling the experimental conditions from the assay technique. Each slide is then probed using immunofluorescence or other optical reporter and assayed by automated microscopy. We show potential applications of the cell chip by assaying HeLa and A549 samples for changes in target protein abundance (of the dsRNA-activated protein kinase PKR), subcellular localization (nuclear translocation of NFkappaB) and activation state (phosphorylation of STAT1 and of the p38 and JNK stress kinases) in response to treatment by several chemical effectors (anisomycin, TNFalpha, and interferon), and we demonstrate scalability by printing a chip with approximately 4,700 discrete samples of HeLa cells. Coupling this technology to high-throughput methods for culturing and treating cell lines could enable researchers to examine the impact of exogenous effectors on the same population of experimentally treated cells across multiple reporter targets potentially representing a variety of molecular systems, thus producing a highly multiplexed dataset with minimized experimental variance and at reduced reagent cost compared to alternative techniques. The ability to prepare and store chips also allows researchers to follow up on observations gleaned from initial screens with maximal repeatability.

  14. Human cell chips: adapting DNA microarray spotting technology to cell-based imaging assays.

    Directory of Open Access Journals (Sweden)

    Traver Hart

    Full Text Available Here we describe human spotted cell chips, a technology for determining cellular state across arrays of cells subjected to chemical or genetic perturbation. Cells are grown and treated under standard tissue culture conditions before being fixed and printed onto replicate glass slides, effectively decoupling the experimental conditions from the assay technique. Each slide is then probed using immunofluorescence or other optical reporter and assayed by automated microscopy. We show potential applications of the cell chip by assaying HeLa and A549 samples for changes in target protein abundance (of the dsRNA-activated protein kinase PKR, subcellular localization (nuclear translocation of NFkappaB and activation state (phosphorylation of STAT1 and of the p38 and JNK stress kinases in response to treatment by several chemical effectors (anisomycin, TNFalpha, and interferon, and we demonstrate scalability by printing a chip with approximately 4,700 discrete samples of HeLa cells. Coupling this technology to high-throughput methods for culturing and treating cell lines could enable researchers to examine the impact of exogenous effectors on the same population of experimentally treated cells across multiple reporter targets potentially representing a variety of molecular systems, thus producing a highly multiplexed dataset with minimized experimental variance and at reduced reagent cost compared to alternative techniques. The ability to prepare and store chips also allows researchers to follow up on observations gleaned from initial screens with maximal repeatability.

  15. On-Chip Supercapacitor Electrode Based On Polypyrrole Deposited Into Nanoporous Au Scaffold

    Science.gov (United States)

    Lu, P.; Ohlckers, P.; Chen, X. Y.

    2016-11-01

    On-chip supercapacitors hold the potential promise for serving as the energy storage units in integrated circuit system, due to their much higher energy density in comparison with conventional dielectric capacitors, high power density and long-term cycling stability. In this study, nanoporous Au (NP-Au) film on-chip was employed as the electrode scaffold to help increase the electrolyte-accessible area for active material. Pseudo-capacitive polypyrrole (PPY) with high theoretical capacitance was deposited into the NP-Au scaffold, to construct the tailored NP-Au/PPY hybrid on-chip electrode with improved areal capacitance. Half cell test in three- electrode system revealed the improved capacitor performance of nanoporous Au supported PPY electrode, compared to the densely packed PPY nanowire film electrode on planer Au substrate (Au/PPY). The areal capacitance of 37 mF/cm2∼10 mV/s, 32 mF/cm2∼50 mV/s, 28 mF/cm2∼100 mV/s, 16 mF/cm2∼500 mV/s, were offered by NP-Au/PPY. Also, the cycling performance was enhanced via using NP-Au scaffold. The developed NP-Au/PPY on-chip electrode demonstrated herein paves a feasible pathway to employ dealloying derived porous metal as the scaffold for improving both the energy density and cycling performance for supercapacitor electrodes.

  16. Design and implementation of a microfluidic half adder chip based on double-stranded DNA.

    Science.gov (United States)

    Wang, Jing; Huang, Yourui

    2014-06-01

    In recent years, DNA computing has gained significant research interest. The design of a biochip with DNA computing as a carrier has become a key area in the development of a DNA molecular computer. The half adder, as the basic unit of various arithmetic units, has a complex structure that directly affects the overall complexity of a computer's structure. In this study, a half adder on a microfluidic chip is developed by means of bio-reaction. This technology is combined with a biochip and adopts glass and polydimethylsiloxane to fabricate a microscale hybrid chip. Using a DNA strand as an operand, realization of the half adder on a microfluidic chip is achieved by controlling the annealing and denaturation of double-stranded DNA. The computing results are rapidly and accurately obtained by detecting the presence of double-stranded DNA in a solution by agarose gel electrophoresis. The microfluidic half-adder chip accurately realizes half-adder computations and overcomes the shortcomings of traditional integrated circuit half adders, optical half adders, and chemical molecule half adders, such as complex structure, limited component size, and low accuracy.

  17. On-chip tunable long-period grating devices based on liquid crystal photonic bandgap fibers

    DEFF Research Database (Denmark)

    Wei, Lei; Weirich, Johannes; Alkeskjold, Thomas Tanggaard;

    2009-01-01

    We design and fabricate an on-chip tunable long-period grating device by integrating a liquid crystal photonic bandgap fiber on silicon structures. The transmission axis of the device can be electrically rotated in steps of 45° as well as switched on and off with the response time in the millisec...

  18. Validation of a fully autonomous phosphate analyser based on a microfluidic lab-on-a-chip

    DEFF Research Database (Denmark)

    Slater, Conor; Cleary, J.; Lau, K.T.

    2010-01-01

    This work describes the design of a phosphate analyser that utilises a microfluidic lab-on-a-chip. The analyser contains all the required chemical storage, pumping and electronic components to carry out a complete phosphate assay. The system is self-calibrating and self-cleaning, thus capable...

  19. Synchronous Generator Model Parameter Estimation Based on Noisy Dynamic Waveforms

    Science.gov (United States)

    Berhausen, Sebastian; Paszek, Stefan

    2016-01-01

    In recent years, there have occurred system failures in many power systems all over the world. They have resulted in a lack of power supply to a large number of recipients. To minimize the risk of occurrence of power failures, it is necessary to perform multivariate investigations, including simulations, of power system operating conditions. To conduct reliable simulations, the current base of parameters of the models of generating units, containing the models of synchronous generators, is necessary. In the paper, there is presented a method for parameter estimation of a synchronous generator nonlinear model based on the analysis of selected transient waveforms caused by introducing a disturbance (in the form of a pseudorandom signal) in the generator voltage regulation channel. The parameter estimation was performed by minimizing the objective function defined as a mean square error for deviations between the measurement waveforms and the waveforms calculated based on the generator mathematical model. A hybrid algorithm was used for the minimization of the objective function. In the paper, there is described a filter system used for filtering the noisy measurement waveforms. The calculation results of the model of a 44 kW synchronous generator installed on a laboratory stand of the Institute of Electrical Engineering and Computer Science of the Silesian University of Technology are also given. The presented estimation method can be successfully applied to parameter estimation of different models of high-power synchronous generators operating in a power system.

  20. BEAT: A Web-Based Boolean Expression Fault-Based Test Case Generation Tool

    Science.gov (United States)

    Chen, T. Y.; Grant, D. D.; Lau, M. F.; Ng, S. P.; Vasa, V. R.

    2006-01-01

    BEAT is a Web-based system that generates fault-based test cases from Boolean expressions. It is based on the integration of our several fault-based test case selection strategies. The generated test cases are considered to be fault-based, because they are aiming at the detection of particular faults. For example, when the Boolean expression is in…

  1. Atom chips

    CERN Document Server

    Reichel, Jakob

    2010-01-01

    This book provides a stimulating and multifaceted picture of a rapidly developing field. The first part reviews fundamentals of atom chip research in tutorial style, while subsequent parts focus on the topics of atom-surface interaction, coherence on atom chips, and possible future directions of atom chip research. The articles are written by leading researchers in the field in their characteristic and individual styles.

  2. On-Chip Single-Photon Sifter

    CERN Document Server

    Elshaari, Ali W; Fognini, Andreas; Reimer, Michael E; Dalacu, Dan; Poole, Philip J; Zwiller, Val; Jöns, Klaus D

    2016-01-01

    Quantum states of light play a pivotal role in modern science[1] and future photonic applications[2]. While impressive progress has been made in their generation and manipulation with high fidelities, the common table-top approach is reaching its limits for practical quantum applications. Since the advent of integrated quantum nanophotonics[3] different material platforms based on III-V nanostructures-, color centers-, and nonlinear waveguides[4-8] as on-chip light sources have been investigated. Each platform has unique advantages and limitations in terms of source properties, optical circuit complexity, and scaling potentials. However, all implementations face major challenges with efficient and tunable filtering of individual quantum states[4], scalable integration and deterministic multiplexing of on-demand selected quantum emitters[9], and on-chip excitation-suppression[10]. Here we overcome all of these challenges with a novel hybrid and scalable nanofabrication approach to generate quantum light on-chi...

  3. Hydrogen-based power generation from bioethanol steam reforming

    Science.gov (United States)

    Tasnadi-Asztalos, Zs.; Cormos, C. C.; Agachi, P. S.

    2015-12-01

    This paper is evaluating two power generation concepts based on hydrogen produced from bioethanol steam reforming at industrial scale without and with carbon capture. The power generation from bioethanol conversion is based on two important steps: hydrogen production from bioethanol catalytic steam reforming and electricity generation using a hydrogen-fuelled gas turbine. As carbon capture method to be assessed in hydrogen-based power generation from bioethanol steam reforming, the gas-liquid absorption using methyl-di-ethanol-amine (MDEA) was used. Bioethanol is a renewable energy carrier mainly produced from biomass fermentation. Steam reforming of bioethanol (SRE) provides a promising method for hydrogen and power production from renewable resources. SRE is performed at high temperatures (e.g. 800-900°C) to reduce the reforming by-products (e.g. ethane, ethene). The power generation from hydrogen was done with M701G2 gas turbine (334 MW net power output). Hydrogen was obtained through catalytic steam reforming of bioethanol without and with carbon capture. For the evaluated plant concepts the following key performance indicators were assessed: fuel consumption, gross and net power outputs, net electrical efficiency, ancillary consumptions, carbon capture rate, specific CO2 emission etc. As the results show, the power generation based on bioethanol conversion has high energy efficiency and low carbon footprint.

  4. Hydrogen-based power generation from bioethanol steam reforming

    Energy Technology Data Exchange (ETDEWEB)

    Tasnadi-Asztalos, Zs., E-mail: tazsolt@chem.ubbcluj.ro; Cormos, C. C., E-mail: cormos@chem.ubbcluj.ro; Agachi, P. S. [Babes-Bolyai University, Faculty of Chemistry and Chemical Engineering, 11 Arany Janos, Postal code: 400028, Cluj-Napoca (Romania)

    2015-12-23

    This paper is evaluating two power generation concepts based on hydrogen produced from bioethanol steam reforming at industrial scale without and with carbon capture. The power generation from bioethanol conversion is based on two important steps: hydrogen production from bioethanol catalytic steam reforming and electricity generation using a hydrogen-fuelled gas turbine. As carbon capture method to be assessed in hydrogen-based power generation from bioethanol steam reforming, the gas-liquid absorption using methyl-di-ethanol-amine (MDEA) was used. Bioethanol is a renewable energy carrier mainly produced from biomass fermentation. Steam reforming of bioethanol (SRE) provides a promising method for hydrogen and power production from renewable resources. SRE is performed at high temperatures (e.g. 800-900°C) to reduce the reforming by-products (e.g. ethane, ethene). The power generation from hydrogen was done with M701G2 gas turbine (334 MW net power output). Hydrogen was obtained through catalytic steam reforming of bioethanol without and with carbon capture. For the evaluated plant concepts the following key performance indicators were assessed: fuel consumption, gross and net power outputs, net electrical efficiency, ancillary consumptions, carbon capture rate, specific CO{sub 2} emission etc. As the results show, the power generation based on bioethanol conversion has high energy efficiency and low carbon footprint.

  5. Extended QoS modelling based on multi-application environment in network on chip

    Science.gov (United States)

    Saadaoui, Abdelkader; Nasri, Salem

    2015-01-01

    Until now, there is no standard method of the quality of service (QoS) measurement and fewer techniques have been used to provide its definition. Therefore, researchers are looking for a projection of QoS on quantifiable space, since it is qualitative, subjective and not measurable. However, a few tentatives have studied QoS parameter estimation. Many applications in network on chip (NoC) present variable QoS parameters such as packet loss rate (PLR), end-to-end delay (EED) and throughput (Thp). However, there are a few papers that have developed different methods to modelise QoS in NoC. Their QoS presentation does not provide a multi-application parameter arbiter. Independently of the approach used, an important challenge associated with QoS provision is the development of an efficient and flexible way to monitor QoS. The originality of our approach is based on a proposition of a QoS-intellectual property module in NoC architecture to improve network performances. We implement an extended approach of QoS metrics modelling for NoC on multi-parameter and multi-application environment. The QoS metrics model is based on QoS parameters such as PLR, EED and Thp for different applications. To validate this work, a dynamic routing simulation for 4 × 4 mesh NoC behaviour under three different applications, namely transmission control protocol, variable bit rate and constant bit rate, is considered. To achieve an ideal network behaviour, load balancing on NoC with multiple concurrent applications is improved using QoS metrics measurement based on dynamic routing. The results have shown that extended QoS modelling approach is easy and cheap to implement in hardware-software quantifiable representation. Thus, implementing a quantifiable representation of QoS can be used to provide a NoC services arbiter. QoS arbiter interacts with other routers to ensure flit flow and QoS modelling to provide a QoS value.

  6. Servo motor control application research based on Xilinx FPGA system generator%Xilinx FPGA system generator 在伺服电机控制中的应用

    Institute of Scientific and Technical Information of China (English)

    程龙; 王卫兵; 王挺峰; 陈娟; 郭劲

    2015-01-01

    In order to avoid the FPGA language HDL code cumbersome,in this paper,by using Simulink integrated toolkit Xilinx FPGA unique System Generator module series,around three servo motor control application has carried on the simulation and experimental research.First of all,according to three kinds of servo motor control PWM signal waveform,the Simulink block diagram was established based on System Generator;Second,the Simulink simulation results correctly generated on the basis of HDL code;Then,using the ISE ModelSim simulation supporting software of HDL code test;Finally,on the basis of the ModelSim simulation results right code to load the FPGA hardware,and by using the ChipScope Pro PWM signal test.Accordance with the experimental results and simulation results,show that the method is simple,has a certain practical application value.%为了避免编写 FPGA 语言 HDL 代码的烦琐性,借助于 Simulink 集成工具箱中 Xilinx 系列 FPGA 独有的System Generator 模块,围绕3种伺服电机控制应用进行了仿真和实验研究。首先,根据3种伺服电机控制所需PWM 信号波形,利用 System Generator 建立 Simulink 仿真框图;其次,在 Simulink 仿真结果正确的基础上生成 HDL代码;然后,利用 ISE 的仿真配套软件 ModelSim 对 HDL 代码仿真测试;最后,在 ModelSim 仿真结果正确的基础上将代码载入 FPGA 硬件,并利用 ChipScope Pro 对 PWM 信号进行实验测试。实验结果与仿真结果的吻合,表明此方法简单易行,具有一定的实际应用价值。

  7. A Prediction-based Smart Meter Data Generator

    DEFF Research Database (Denmark)

    Iftikhar, Nadeem; Nordbjerg, Finn Ebertsen

    2016-01-01

    With the prevalence of cloud computing and Internet of Things (IoT), smart meters have become one of the main components of smart city strategy. Smart meters generate large amounts of fine-grained data that is used to provide useful information to consumers and utility companies for decisionmaking....... Now-a-days, smart meter analytics systems consist of analytical algorithms that process massive amounts of data. These analytics algorithms require ample amounts of realistic data for testing and verification purposes. However, it is usually difficult to obtain adequate amounts of realistic data......, mainly due to privacy issues. This paper proposes a smart meter data generator that can generate realistic energy consumption data by making use of a small real-world data set as seed. The generator generates data using a prediction-based method that depends on historical energy consumption patterns...

  8. A Prediction-based Smart Meter Data Generator

    DEFF Research Database (Denmark)

    Iftikhar, Nadeem; Liu, Xiufeng; Nordbjerg, Finn Ebertsen

    With the prevalence of cloud computing and In-ternet of Things (IoT), smart meters have become one of the main components of smart city strategy. Smart meters generate large amounts of fine-grained data that is used to provide useful information to consumers and utility companies for decision......-making. Now-a-days, smart meter analytics systems consist of analytical algorithms that process massive amounts of data. These analytics algorithms require ample amounts of realistic data for testing and verification purposes. However, it is usually difficult to obtain adequate amounts of realistic data......, mainly due to privacy issues. This paper proposes a smart meter data generator that can generate realistic energy consumption data by making use of a small real-world dataset as seed. The generator generates data using a prediction-based method that depends on historical energy consumption patterns along...

  9. Aging assessment of large generator insulation based on PD measurements

    Institute of Scientific and Technical Information of China (English)

    YUE Bo; CHEN Xiaolin; CHENG Yonghong; XIE Hengkun

    2005-01-01

    The statistical parameters of phase resolved partial discharge (PD) distribution and ultra-wideband (UWB) characteristics of PD pulse are proposed for aging assessment of large generator insulation. Multi-stress aging tests of the model generator stator bar specimens were performed and PD measurements were conducted using both digital PD detector with frequency ranging from 40 kHz to 400 kHz and UWB PD detector with bandwidth from 10 MHz to 3 GHz at different aging stages. The test results show that the skewness and UWB frequency characteristics of PD can be taken as the characterization parameters for aging assessment of generator insulation. Furthermore, the measurement results of real generator stator bars show that these methods based on statistical parameters and UWB characteristics of PD are prospective for aging assessment and residual lifetime estimation of large generator stator insulation.

  10. Chaos-based Pseudo-random Number Generation

    KAUST Repository

    Barakat, Mohamed L.

    2014-04-10

    Various methods and systems related to chaos-based pseudo-random number generation are presented. In one example, among others, a system includes a pseudo-random number generator (PRNG) to generate a series of digital outputs and a nonlinear post processing circuit to perform an exclusive OR (XOR) operation on a first portion of a current digital output of the PRNG and a permutated version of a corresponding first portion of a previous post processed output to generate a corresponding first portion of a current post processed output. In another example, a method includes receiving at least a first portion of a current output from a PRNG and performing an XOR operation on the first portion of the current PRNG output with a permutated version of a corresponding first portion of a previous post processed output to generate a corresponding first portion of a current post processed output.

  11. The guitar chord-generating algorithm based on complex network

    Science.gov (United States)

    Ren, Tao; Wang, Yi-fan; Du, Dan; Liu, Miao-miao; Siddiqi, Awais

    2016-02-01

    This paper aims to generate chords for popular songs automatically based on complex network. Firstly, according to the characteristics of guitar tablature, six chord networks of popular songs by six pop singers are constructed and the properties of all networks are concluded. By analyzing the diverse chord networks, the accompaniment regulations and features are shown, with which the chords can be generated automatically. Secondly, in terms of the characteristics of popular songs, a two-tiered network containing a verse network and a chorus network is constructed. With this network, the verse and chorus can be composed respectively with the random walk algorithm. Thirdly, the musical motif is considered for generating chords, with which the bad chord progressions can be revised. This method can make the accompaniments sound more melodious. Finally, a popular song is chosen for generating chords and the new generated accompaniment sounds better than those done by the composers.

  12. An OCP Compliant Network Adapter for GALS-based SoC Design Using the MANGO Network-on-Chip

    DEFF Research Database (Denmark)

    Bjerregaard, Tobias; Mahadevan, Shankar; Olsen, Rasmus Grøndahl

    2005-01-01

    decouples communication and computation, providing memory-mapped OCP transactions based on primitive message-passing services of the network. Also, it facilitates GALS-type systems, by adapting to the clockless network. This helps leverage a modular SoC design flow. We evaluate performance and cost of 0......The demand for IP reuse and system level scalability in System-on-Chip (SoC) designs is growing. Network-onchip (NoC) constitutes a viable solution space to emerging SoC design challenges. In this paper we describe an OCP compliant network adapter (NA) architecture for the MANGO NoC. The NA...

  13. Randomness generation based on spontaneous emissions of lasers

    Science.gov (United States)

    Zhou, Hongyi; Yuan, Xiao; Ma, Xiongfeng

    2015-06-01

    Random numbers play a key role in information science, especially in cryptography. Based on the probabilistic nature of quantum mechanics, quantum random number generators can produce genuine randomness. In particular, random numbers can be produced from laser phase fluctuations with a very high speed, typically in the Gbps regime. In this work, by developing a physical model, we investigate the origin of the randomness in quantum random number generators based on laser phase fluctuations. We show how the randomness essentially stems from spontaneous emissions. The laser phase fluctuation can be quantitatively evaluated from basic principles and qualitatively explained by the Brownian motion model. After taking account of practical device precision, we show that the randomness generation speed is limited by the finite resolution of detection devices. Our result also provides the optimal experiment design in order to achieve the maximum generation speed.

  14. Automatic Structure-Based Code Generation from Coloured Petri Nets

    DEFF Research Database (Denmark)

    Kristensen, Lars Michael; Westergaard, Michael

    2010-01-01

    Automatic code generation based on Coloured Petri Net (CPN) models is challenging because CPNs allow for the construction of abstract models that intermix control flow and data processing, making translation into conventional programming constructs difficult. We introduce Process-Partitioned CPNs....... The viability of our approach is demonstrated by applying it to automatically generate an Erlang implementation of the Dynamic MANET On-demand (DYMO) routing protocol specified by the Internet Engineering Task Force (IETF)....

  15. MEMS-Based Power Generation Techniques for Implantable Biosensing Applications

    Directory of Open Access Journals (Sweden)

    Jonathan Lueke

    2011-01-01

    Full Text Available Implantable biosensing is attractive for both medical monitoring and diagnostic applications. It is possible to monitor phenomena such as physical loads on joints or implants, vital signs, or osseointegration in vivo and in real time. Microelectromechanical (MEMS-based generation techniques can allow for the autonomous operation of implantable biosensors by generating electrical power to replace or supplement existing battery-based power systems. By supplementing existing battery-based power systems for implantable biosensors, the operational lifetime of the sensor is increased. In addition, the potential for a greater amount of available power allows additional components to be added to the biosensing module, such as computational and wireless and components, improving functionality and performance of the biosensor. Photovoltaic, thermovoltaic, micro fuel cell, electrostatic, electromagnetic, and piezoelectric based generation schemes are evaluated in this paper for applicability for implantable biosensing. MEMS-based generation techniques that harvest ambient energy, such as vibration, are much better suited for implantable biosensing applications than fuel-based approaches, producing up to milliwatts of electrical power. High power density MEMS-based approaches, such as piezoelectric and electromagnetic schemes, allow for supplemental and replacement power schemes for biosensing applications to improve device capabilities and performance. In addition, this may allow for the biosensor to be further miniaturized, reducing the need for relatively large batteries with respect to device size. This would cause the implanted biosensor to be less invasive, increasing the quality of care received by the patient.

  16. Random number generation based on digital differential chaos

    KAUST Repository

    Zidan, Mohammed A.

    2012-07-29

    In this paper, we present a fully digital differential chaos based random number generator. The output of the digital circuit is proved to be chaotic by calculating the output time series maximum Lyapunov exponent. We introduce a new post processing technique to improve the distribution and statistical properties of the generated data. The post-processed output passes the NIST Sp. 800-22 statistical tests. The system is written in Verilog VHDL and realized on Xilinx Virtex® FPGA. The generator can fit into a very small area and have a maximum throughput of 2.1 Gb/s.

  17. Osmosis-based pressure generation: dynamics and application.

    Science.gov (United States)

    Bruhn, Brandon R; Schroeder, Thomas B H; Li, Suyi; Billeh, Yazan N; Wang, K W; Mayer, Michael

    2014-01-01

    This paper describes osmotically-driven pressure generation in a membrane-bound compartment while taking into account volume expansion, solute dilution, surface area to volume ratio, membrane hydraulic permeability, and changes in osmotic gradient, bulk modulus, and degree of membrane fouling. The emphasis lies on the dynamics of pressure generation; these dynamics have not previously been described in detail. Experimental results are compared to and supported by numerical simulations, which we make accessible as an open source tool. This approach reveals unintuitive results about the quantitative dependence of the speed of pressure generation on the relevant and interdependent parameters that will be encountered in most osmotically-driven pressure generators. For instance, restricting the volume expansion of a compartment allows it to generate its first 5 kPa of pressure seven times faster than without a restraint. In addition, this dynamics study shows that plants are near-ideal osmotic pressure generators, as they are composed of many small compartments with large surface area to volume ratios and strong cell wall reinforcements. Finally, we demonstrate two applications of an osmosis-based pressure generator: actuation of a soft robot and continuous volume delivery over long periods of time. Both applications do not need an external power source but rather take advantage of the energy released upon watering the pressure generators.

  18. Osmosis-based pressure generation: dynamics and application.

    Directory of Open Access Journals (Sweden)

    Brandon R Bruhn

    Full Text Available This paper describes osmotically-driven pressure generation in a membrane-bound compartment while taking into account volume expansion, solute dilution, surface area to volume ratio, membrane hydraulic permeability, and changes in osmotic gradient, bulk modulus, and degree of membrane fouling. The emphasis lies on the dynamics of pressure generation; these dynamics have not previously been described in detail. Experimental results are compared to and supported by numerical simulations, which we make accessible as an open source tool. This approach reveals unintuitive results about the quantitative dependence of the speed of pressure generation on the relevant and interdependent parameters that will be encountered in most osmotically-driven pressure generators. For instance, restricting the volume expansion of a compartment allows it to generate its first 5 kPa of pressure seven times faster than without a restraint. In addition, this dynamics study shows that plants are near-ideal osmotic pressure generators, as they are composed of many small compartments with large surface area to volume ratios and strong cell wall reinforcements. Finally, we demonstrate two applications of an osmosis-based pressure generator: actuation of a soft robot and continuous volume delivery over long periods of time. Both applications do not need an external power source but rather take advantage of the energy released upon watering the pressure generators.

  19. Integrated electrokinetic magnetic bead-based electrochemical immunoassay on microfluidic chips for reliable control of permitted levels of zearalenone in infant foods.

    Science.gov (United States)

    Hervás, Mirian; López, Miguel A; Escarpa, Alberto

    2011-05-21

    Microfluidic technology has now become a novel sensing platform where different analytical steps, biological recognition materials and suitable transducers can be cleverly integrated yielding a new sensor generation. A novel "lab-on-a-chip" strategy integrating an electrokinetic magnetic bead-based electrochemical immunoassay on a microfluidic chip for reliable control of permitted levels of zearalenone in infant foods is proposed. The strategy implies the creative use of the simple channel layout of the double-T microchip to perform sequentially the immunointeraction and enzymatic reaction by applying a program of electric fields suitably connected to the reservoirs for driving the fluidics at different chambers in order to perform the different reactions. Both zones are used with the aid of a magnetic field to avoid in a very simple and elegant way the non-specific adsorption. Immunological reaction is performed under a competitive enzyme-linked immunosorbent assay (ELISA) where the mycotoxin ZEA and an enzyme-labelled derivative compete for the binding sites of the specific monoclonal antibody immobilised onto protein G modified magnetic beads. Horseradish peroxidase (HRP), in the presence of hydrogen peroxide, catalyses the oxidation of hydroquinone (HQ) to benzoquinone (BQN), whose back electrochemical reduction was detected at +0.1 V. Controlled-electrokinetic fluidic handling optimized conditions are addressed for all analytical steps cited above, and allows performing the complete immunoassay for the target ZEA analyte in less than 15 minutes with unique analytical merits: competitive immunoassay currents showed a very well-defined concentration dependence with a good precision as well as a suitable limit of detection of 0.4 µg L(-1), well below the legislative requirements, and an extremely low systematic error of 2% from the analysis of a maize certified reference material revealing additionally an excellent accuracy. Also, the reliability of the

  20. One Step Quick Detection of Cancer Cell Surface Marker by Integrated NiFe-based Magnetic Biosensing Cell Cultural Chip

    Institute of Scientific and Technical Information of China (English)

    Chenchen Bao; Lei Chen; Tao Wang; Chong Lei; Furong Tian; Daxiang Cui; Yong Zhou

    2013-01-01

    RGD peptides has been used to detect cell surface integrin and direct clinical effective therapeutic drug selection. Herein we report that a quick one step detection of cell surface marker that was realized by a specially designed NiFe-based magnetic biosensing cell chip combined with functionalized magnetic nanoparti-cles. Magnetic nanoparticles with 20-30 nm in diameter were prepared by coprecipitation and modified with RGD-4C, and the resultant RGD-functionalized magnetic nanoparticles were used for targeting cancer cells cul-tured on the NiFe-based magnetic biosensing chip and distinguish the amount of cell surface receptor-integrin. Cell lines such as Calu3, Hela, A549, CaFbr, HEK293 and HUVEC exhibiting different integrin expression were chosen as test samples. Calu3, Hela, HEK293 and HUVEC cells were successfully identified. This approach has advantages in the qualitative screening test. Compared with traditional method, it is fast, sensitive, low cost, easy-operative, and needs very little human intervention. The novel method has great potential in applications such as fast clinical cell surface marker detection, and diagnosis of early cancer, and can be easily extended to other biomedical applications based on molecular recognition.

  1. Generation of microgrooved silica nanotube membranes with sustained drug delivery and cell contact guidance ability by using a Teflon microfluidic chip

    Directory of Open Access Journals (Sweden)

    Song Chen, Xuetao Shi, Shanmugavel Chinnathambi, Hongkai Wu and Nobutaka Hanagata

    2013-01-01

    Full Text Available Silica nanotubes have been extensively applied in the biomedical field. However, very little attention has been paid to the fabrication and application of micropatterned silica nanotubes. In the present study, microgrooved silica nanotube membranes were fabricated in situ by microgrooving silica-coated collagen hybrid fibril hydrogels in a Teflon microfluidic chip followed by calcination for removal of collagen fibrils. Scanning electron microscopy images showed that the resulting silica nanotube membranes displayed a typical microgroove/ridge surface topography with ~50 μm microgroove width and ~120 μm ridge width. They supported adsorption of bone morphogenetic protein 2 (BMP-2 and exhibited a sustained release behavior for BMP-2. After culturing with osteoblast MC3T3-E1 cells, they induced an enhanced osteoblast differentiation due to the release of biologically active BMP-2 and a strong contact guidance ability to directly align and elongate osteoblasts due to the presence of microgrooved surface topography, indicating their potential application as a multi-functional cell-supporting matrix for tissue generation.

  2. Generation of microgrooved silica nanotube membranes with sustained drug delivery and cell contact guidance ability by using a Teflon microfluidic chip

    Science.gov (United States)

    Chen, Song; Shi, Xuetao; Chinnathambi, Shanmugavel; Wu, Hongkai; Hanagata, Nobutaka

    2013-02-01

    Silica nanotubes have been extensively applied in the biomedical field. However, very little attention has been paid to the fabrication and application of micropatterned silica nanotubes. In the present study, microgrooved silica nanotube membranes were fabricated in situ by microgrooving silica-coated collagen hybrid fibril hydrogels in a Teflon microfluidic chip followed by calcination for removal of collagen fibrils. Scanning electron microscopy images showed that the resulting silica nanotube membranes displayed a typical microgroove/ridge surface topography with ˜50 μm microgroove width and ˜120 μm ridge width. They supported adsorption of bone morphogenetic protein 2 (BMP-2) and exhibited a sustained release behavior for BMP-2. After culturing with osteoblast MC3T3-E1 cells, they induced an enhanced osteoblast differentiation due to the release of biologically active BMP-2 and a strong contact guidance ability to directly align and elongate osteoblasts due to the presence of microgrooved surface topography, indicating their potential application as a multi-functional cell-supporting matrix for tissue generation.

  3. Formal Specification Based Automatic Test Generation for Embedded Network Systems

    Directory of Open Access Journals (Sweden)

    Eun Hye Choi

    2014-01-01

    Full Text Available Embedded systems have become increasingly connected and communicate with each other, forming large-scaled and complicated network systems. To make their design and testing more reliable and robust, this paper proposes a formal specification language called SENS and a SENS-based automatic test generation tool called TGSENS. Our approach is summarized as follows: (1 A user describes requirements of target embedded network systems by logical property-based constraints using SENS. (2 Given SENS specifications, test cases are automatically generated using a SAT-based solver. Filtering mechanisms to select efficient test cases are also available in our tool. (3 In addition, given a testing goal by the user, test sequences are automatically extracted from exhaustive test cases. We’ve implemented our approach and conducted several experiments on practical case studies. Through the experiments, we confirmed the efficiency of our approach in design and test generation of real embedded air-conditioning network systems.

  4. Recent Advances in Room Temperature, High-Power Terahertz Quantum Cascade Laser Sources Based on Difference-Frequency Generation

    Directory of Open Access Journals (Sweden)

    Quanyong Lu

    2016-07-01

    Full Text Available We present the current status of high-performance, compact, THz sources based on intracavity nonlinear frequency generation in mid-infrared quantum cascade lasers. Significant performance improvements of our THz sources in the power and wall plug efficiency are achieved by systematic optimizing the device’s active region, waveguide, and chip bonding strategy. High THz power up to 1.9 mW and 0.014 mW for pulsed mode and continuous wave operations at room temperature are demonstrated, respectively. Even higher power and efficiency are envisioned based on enhancements in outcoupling efficiency and mid-IR performance. Our compact THz device with high power and wide tuning range is highly suitable for imaging, sensing, spectroscopy, medical diagnosis, and many other applications.

  5. Facilitating the commercialization and use of organ platforms generated by the microphysiological systems (Tissue Chip program through public–private partnerships

    Directory of Open Access Journals (Sweden)

    Christine A. Livingston

    2016-01-01

    Full Text Available Microphysiological systems (organs-on-chips, tissue chips are devices designed to recapitulate human physiology that could be used to better understand drug responses not easily addressed using other in vivo systems or in vitro animal models. Although still in development, initial results seem promising as tissue chips exhibit in vivo systems-like functional responses. The National Center for Advancing Translation Science (NCATS identifies this technology as a potential tool that could improve the process of getting safer, more effective treatments to patients, and has led to the Tissue Chip Program, which aims to develop, integrate and validate major organ systems for testing. In addition to organ chip development, NCATS emphasizes disseminating the technology to researchers. Commercialization has become an important issue, reflecting the difficulty of translation from discovery to adoption and wide availability. Therefore, NCATS issued a Request for Information (RFI targeted to existing partnerships for commercializing tissue chips. The goal was to identify successes, failures and the best practices that could provide useful guidance for future partnerships aiming to make tissue chip technology widely available.

  6. Facilitating the commercialization and use of organ platforms generated by the microphysiological systems (Tissue Chip) program through public-private partnerships.

    Science.gov (United States)

    Livingston, Christine A; Fabre, Kristin M; Tagle, Danilo A

    2016-01-01

    Microphysiological systems (organs-on-chips, tissue chips) are devices designed to recapitulate human physiology that could be used to better understand drug responses not easily addressed using other in vivo systems or in vitro animal models. Although still in development, initial results seem promising as tissue chips exhibit in vivo systems-like functional responses. The National Center for Advancing Translation Science (NCATS) identifies this technology as a potential tool that could improve the process of getting safer, more effective treatments to patients, and has led to the Tissue Chip Program, which aims to develop, integrate and validate major organ systems for testing. In addition to organ chip development, NCATS emphasizes disseminating the technology to researchers. Commercialization has become an important issue, reflecting the difficulty of translation from discovery to adoption and wide availability. Therefore, NCATS issued a Request for Information (RFI) targeted to existing partnerships for commercializing tissue chips. The goal was to identify successes, failures and the best practices that could provide useful guidance for future partnerships aiming to make tissue chip technology widely available.

  7. Experiment list: SRX107354 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available matin IP against RXRa and RARg. In house polyclonal antibodies generated by immun...CSKPGPHPKASSEDEAPGGQGKRGQSPQPD)] || chip antibody=in-house polyclonal Ab against RXRa and RAR || chip antibo

  8. Experiment list: SRX087269 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available -RXRa || chip antibody supplier=in-house antibody [generated by immunization of r...ce_name=embryonal carcinoma cells || cell line=F9 embryonal carcinoma cells || chip antibody=polyclonal anti

  9. Novel Frequency Hopping Sequences Generator Based on AES Algorithm

    Institute of Scientific and Technical Information of China (English)

    李振荣; 庄奕琪; 张博; 张超

    2010-01-01

    A novel frequency hopping(FH) sequences generator based on advanced encryption standard(AES) iterated block cipher is proposed for FH communication systems.The analysis shows that the FH sequences based on AES algorithm have good performance in uniformity, correlation, complexity and security.A high-speed, low-power and low-cost ASIC of FH sequences generator is implemented by optimizing the structure of S-Box and MixColumns of AES algorithm, proposing a hierarchical power management strategy, and applying ...

  10. Skyrmion-based high-frequency signal generator

    Science.gov (United States)

    Luo, Shijiang; Zhang, Yue; Shen, Maokang; Ou-Yang, Jun; Yan, Baiqian; Yang, Xiaofei; Chen, Shi; Zhu, Benpeng; You, Long

    2017-03-01

    Many concepts for skyrmion-based devices have been proposed, and most of their possible applications are based on the motion of skyrmions driven by a dc current in an area with a constricted geometry. However, skyrmion motion driven by a pulsed current has not been investigated so far. In this work, we propose a skyrmion-based high-frequency signal generator based on the pulsed-current-driven circular motion of skyrmions in a square-shaped film by micromagnetic simulation. The results indicate that skyrmions can move in a closed curve with central symmetry. The trajectory and cycle period can be adjusted by tuning the size of the film, the current density, the Dzyaloshinskii-Moriya interaction constant, and the local in-plane magnetic anisotropy. The period can be tuned from several nanoseconds to tens of nanoseconds, which offers the possibility to prepare high-frequency signal generator based on skyrmions.

  11. Raman-Spectroscopy Based Cell Identification on a Microhole Array Chip

    Directory of Open Access Journals (Sweden)

    Ute Neugebauer

    2014-04-01

    Full Text Available Circulating tumor cells (CTCs from blood of cancer patients are valuable prognostic markers and enable monitoring responses to therapy. The extremely low number of CTCs makes their isolation and characterization a major technological challenge. For label-free cell identification a novel combination of Raman spectroscopy with a microhole array platform is described that is expected to support high-throughput and multiplex analyses. Raman spectra were registered from regularly arranged cells on the chip with low background noise from the silicon nitride chip membrane. A classification model was trained to distinguish leukocytes from myeloblasts (OCI-AML3 and breast cancer cells (MCF-7 and BT-20. The model was validated by Raman spectra of a mixed cell population. The high spectral quality, low destructivity and high classification accuracy suggests that this approach is promising for Raman activated cell sorting.

  12. TOT01, a time-over-threshold based readout chip in 180nm CMOS technology for silicon strip detectors

    Science.gov (United States)

    Kasinski, K.; Szczygiel, R.; Gryboś, P.

    2011-01-01

    This work is focused on the development of the TOT01 prototype front-end ASIC for the readout of long silicon strip detectors in the STS (Silicon Tracking System) of the CBM experiment at FAIR - GSI. The deposited charge measurement is based on the Time-over-Threshold method which allows integration of a low-power ADC into each channel. The TOT01 chip comprises 30 identical channels and 1 test channel which is supplied with additional test pads. The major blocks of each channel are the CSA (charge sensitive amplifier) with two switchable constant-current discharge circuits and additional test features. The architecture of the CSA core is based on the folded cascode. The input p-channel MOSFET device, biased at a drain current 500 μA, was optimized for 30 pF detector capacitance while keeping in mind the area constraints — W/L = 1800 μm / 0.180 μm. The main advantage of this solution is high gain (GBW = 1.2 GHz) and low power consumption at the same time. The amplifier is followed by the discriminator circuit. The discriminator allows for a global (multi-channel) differential threshold setting and independent compensation for the CSA output DC-level deviations in each channel by means of a 6-bit digital to analog converter (DAC). The output pulse of this processing chain is fed through a 31:1 multiplexer structure to the output of the chip for further processing. The TOT01 chip has been fabricated in the UMC 0.18 μm CMOS process (Europractice mini@sic). It has 78 pads, measures approximately 1.5x3.2 mm2 and dissipates 33 mW. The channels have 50 μm pitch and each consumes 1.05 mW of power. The chip has been successfully tested. Charge sensitivity parameters, noise performance and first X-ray acquisitions are presented.

  13. Liquid-phase microextraction in a microfluidic-chip

    DEFF Research Database (Denmark)

    Payán, María D. Ramos; Jensen, Henrik; Petersen, Nickolaj J.

    2012-01-01

    In this work, a microfluidic-chip based system for liquid-phase microextraction (LPME-chip) was developed. Sample solutions were pumped into the LPME-chip with a micro-syringe pump at a flow rate of 3-4µLmin(-1). Inside the LPME chip, the sample was in direct contact with a supported liquid...

  14. Human Cell Chips: Adapting DNA Microarray Spotting Technology to Cell-Based Imaging Assays

    OpenAIRE

    Traver Hart; Alice Zhao; Ankit Garg; Swetha Bolusani; Marcotte, Edward M.

    2009-01-01

    Here we describe human spotted cell chips, a technology for determining cellular state across arrays of cells subjected to chemical or genetic perturbation. Cells are grown and treated under standard tissue culture conditions before being fixed and printed onto replicate glass slides, effectively decoupling the experimental conditions from the assay technique. Each slide is then probed using immunofluorescence or other optical reporter and assayed by automated microscopy. We show potential ap...

  15. Accessible morphohistochemical labs-on-a-chip based on different counting chambers' grids: microfluidic morphodynamical workstations

    OpenAIRE

    Gradov O.V.; Notchenko A.V.

    2012-01-01

    An accessible design of autonomous labs on the chip which do not require a special reader is developed. The proposed device uses hemocytometric counting chambers for determinati on of concentration of cells, isolated by a special device for cell sedimentation. A system of automated Rf-identification of chambers in the long-term storage is proposed which provides new morphometric data at various stages of cultivation or biomonitoring. A ne w diffraction method of calcu-lation and fingerprinti...

  16. High-sensitivity high-throughput chip based biosensor array for multiplexed detection of heavy metals

    Science.gov (United States)

    Yan, Hai; Tang, Naimei; Jairo, Grace A.; Chakravarty, Swapnajit; Blake, Diane A.; Chen, Ray T.

    2016-03-01

    Heavy metal ions released into the environment from industrial processes lead to various health hazards. We propose an on-chip label-free detection approach that allows high-sensitivity and high-throughput detection of heavy metals. The sensing device consists of 2-dimensional photonic crystal microcavities that are combined by multimode interferometer to form a sensor array. We experimentally demonstrate the detection of cadmium-chelate conjugate with concentration as low as 5 parts-per-billion (ppb).

  17. Picoliter Well Array Chip-Based Digital Recombinase Polymerase Amplification for Absolute Quantification of Nucleic Acids

    Science.gov (United States)

    Li, Zhao; Liu, Yong; Wei, Qingquan; Liu, Yuanjie; Liu, Wenwen; Zhang, Xuelian; Yu, Yude

    2016-01-01

    Absolute, precise quantification methods expand the scope of nucleic acids research and have many practical applications. Digital polymerase chain reaction (dPCR) is a powerful method for nucleic acid detection and absolute quantification. However, it requires thermal cycling and accurate temperature control, which are difficult in resource-limited conditions. Accordingly, isothermal methods, such as recombinase polymerase amplification (RPA), are more attractive. We developed a picoliter well array (PWA) chip with 27,000 consistently sized picoliter reactions (314 pL) for isothermal DNA quantification using digital RPA (dRPA) at 39°C. Sample loading using a scraping liquid blade was simple, fast, and required small reagent volumes (i.e., <20 μL). Passivating the chip surface using a methoxy-PEG-silane agent effectively eliminated cross-contamination during dRPA. Our creative optical design enabled wide-field fluorescence imaging in situ and both end-point and real-time analyses of picoliter wells in a 6-cm2 area. It was not necessary to use scan shooting and stitch serial small images together. Using this method, we quantified serial dilutions of a Listeria monocytogenes gDNA stock solution from 9 × 10-1 to 4 × 10-3 copies per well with an average error of less than 11% (N = 15). Overall dRPA-on-chip processing required less than 30 min, which was a 4-fold decrease compared to dPCR, requiring approximately 2 h. dRPA on the PWA chip provides a simple and highly sensitive method to quantify nucleic acids without thermal cycling or precise micropump/microvalve control. It has applications in fast field analysis and critical clinical diagnostics under resource-limited settings. PMID:27074005

  18. Reclamation Of Plant Wastes (Straw And Obtaining (Nano Chips With Bactericidal Properties Based On Them

    Directory of Open Access Journals (Sweden)

    Leonidovna Voropaeva Nadezda

    2015-09-01

    Full Text Available Rape, camelina, wheat and Jerusalem artichoke vegetable wastes (straw as annually renewable raw materials were processed into activated carbons, which were modified with silver nanoparticles for carbonaceous sorbents to acquire specific properties, since carbonaceous sorbents are usually widely used in the food industry, agriculture, medicine and other fields of human activity. The technology to obtain active carbons from agricultural crop residues has been developed, active carbon physico-chemical and adsorption properties, textural characteristics have been studied, new functional carbon (nano materials with antibacterial activity containing (nano particles of silver have been obtained, their influence within (nano chip composition on rape crop growth, development and yield has been studied. In the conducted field tests, the highest activity was noted when using the (nano chip whose structure included RAC - camelina and silver nanoparticles. Besides, when nano chips are used for seed treatment, the yield increase makes up 11.6 % for nanoparticles containing Ag, for plant active carbons (PAC (rape with Ag this index makes up 28.1 %, for RAC (Camelina with Ag it makes up 55.8 % (compared to the control variant, which can be explained by the differences in the sorption characteristics of the studied radio activated carbons. Our results and the previous studies of other authors can prove the fact that silver nanoparticles (including those being a part of (nano chips “get” into the biochemical processes and have a pronounced phytostimulating effect on plants, which was especially obvious when suppressing the activity of plant pathogenic microflora by silver nanoparticles.

  19. Defense Against Chip Cloning Attacks Based on Fractional Hopfield Neural Networks.

    Science.gov (United States)

    Pu, Yi-Fei; Yi, Zhang; Zhou, Ji-Liu

    2017-06-01

    This paper presents a state-of-the-art application of fractional hopfield neural networks (FHNNs) to defend against chip cloning attacks, and provides insight into the reason that the proposed method is superior to physically unclonable functions (PUFs). In the past decade, PUFs have been evolving as one of the best types of hardware security. However, the development of the PUFs has been somewhat limited by its implementation cost, its temperature variation effect, its electromagnetic interference effect, the amount of entropy in it, etc. Therefore, it is imperative to discover, through promising mathematical methods and physical modules, some novel mechanisms to overcome the aforementioned weaknesses of the PUFs. Motivated by this need, in this paper, we propose applying the FHNNs to defend against chip cloning attacks. At first, we implement the arbitrary-order fractor of a FHNN. Secondly, we describe the implementation cost of the FHNNs. Thirdly, we propose the achievement of the constant-order performance of a FHNN when ambient temperature varies. Fourthly, we analyze the electrical performance stability of the FHNNs under electromagnetic disturbance conditions. Fifthly, we study the amount of entropy of the FHNNs. Lastly, we perform experiments to analyze the pass-band width of the fractor of an arbitrary-order FHNN and the defense against chip cloning attacks capability of the FHNNs. In particular, the capabilities of defense against chip cloning attacks, anti-electromagnetic interference, and anti-temperature variation of a FHNN are illustrated experimentally in detail. Some significant advantages of the FHNNs are that their implementation cost is considerably lower than that of the PUFs, their electrical performance is much more stable than that of the PUFs under different temperature conditions, their electrical performance stability of the FHNNs under electromagnetic disturbance conditions is much more robust than that of the PUFs, and their amount of

  20. A Pseudo-Random Number Generator Based on Normal Numbers

    Energy Technology Data Exchange (ETDEWEB)

    Bailey, David H.

    2004-12-31

    In a recent paper, Richard Crandall and the present author established that each of a certain class of explicitly given real constants, uncountably infinite in number, is b-normal, for an integer that appears in the formula defining the constant. A b-normal constant is one where every string of m digits appears in the base-b expansion of the constant with limiting frequency b{sup -m}. This paper shows how this result can be used to fashion an efficient and effective pseudo-random number generator, which generates successive strings of binary digits from one of the constants in this class. The resulting generator, which tests slightly faster than a conventional linear congruential generator, avoids difficulties with large power-of-two data access strides that may occur when using conventional generators. It is also well suited for parallel processing--each processor can quickly and independently compute its starting value, with the collective sequence generated by all processors being the same as that generated by a single processor.

  1. Potential of Biomass Based Electricity Generation in Sri Lanka

    Directory of Open Access Journals (Sweden)

    KP Ariyadasa

    2015-12-01

    Full Text Available Biomass has attracted much attention as a primary energy source for electricity generation due to its potential to supply low cost fuel source with considerable environmental and socio-economic benefits. Despite having favorable climatic conditions to grow and use biomass for electricity generation, biomass based electricity generation in Sri Lanka is lagging behind due to many reasons. Many countries rely on the agricultural or forestry by-products or residuals as the main source of biomass for electricity generation mainly due to the comparatively low cost and sustainable supply of these by-products. Sri Lanka does not have this advantage and has to rely mainly on purposely grown biomass for electricity generation. Development of short rotation energy plantations seems to be the best option available for Sri Lanka to produce biomass for commercial scale electricity generation. The highly favorable growing conditions, availability of promising tree species and a variety of plantation management options and significant environmental and socio-economic benefits associated with energy plantation development greatly favor this option. This paper examines the potential of using plantation grown biomass as a fuel source for electricity generation in Sri Lanka.

  2. Cytotoxicity of cadmium-containing quantum dots based on a study using a microfluidic chip

    Science.gov (United States)

    Zheng, Xiannuo; Tian, Jing; Weng, Lixing; Wu, Lei; Jin, Qinghui; Zhao, Jianlong; Wang, Lianhui

    2012-02-01

    There is a lack of reliable nanotoxicity assays available for monitoring and quantifying multiple cellular events in cultured cells. In this study, we used a microfluidic chip to systematically investigate the cytotoxicity of three kinds of well-characterized cadmium-containing quantum dots (QDs) with the same core but different shell structures, including CdTe core QDs, CdTe/CdS core-shell QDs, and CdTe/CdS/ZnS core-shell-shell QDs, in HEK293 cells. Using the microfluidic chip combined with fluorescence microscopy, multiple QD-induced cellular events including cell morphology, viability, proliferation, and QD uptake were simultaneously analysed. The three kinds of QDs showed significantly different cytotoxicities. The CdTe QDs, which are highly toxic to HEK293 cells, resulted in remarkable cellular and nuclear morphological changes, a dose-dependent decrease in cell viability, and strong inhibition of cell proliferation; the CdTe/CdS QDs were moderately toxic but did not significantly affect the proliferation of HEK293 cells; while the CdTe/CdS/ZnS QDs had no detectable influence on cytotoxicity with respect to cell morphology, viability, and proliferation. Our data indicated that QD cytotoxicity was closely related to their surface structures and specific physicochemical properties. This study also demonstrated that the microfluidic chip could serve as a powerful tool to systematically evaluate the cytotoxicity of nanoparticles in multiple cellular events.

  3. Integrated lab-on-chip biosensing systems based on magnetic particle actuation--a comprehensive review.

    Science.gov (United States)

    van Reenen, Alexander; de Jong, Arthur M; den Toonder, Jaap M J; Prins, Menno W J

    2014-06-21

    The demand for easy to use and cost effective medical technologies inspires scientists to develop innovative lab-on-chip technologies for point-of-care in vitro diagnostic testing. To fulfill medical needs, the tests should be rapid, sensitive, quantitative, and miniaturizable, and need to integrate all steps from sample-in to result-out. Here, we review the use of magnetic particles actuated by magnetic fields to perform the different process steps that are required for integrated lab-on-chip diagnostic assays. We discuss the use of magnetic particles to mix fluids, to capture specific analytes, to concentrate analytes, to transfer analytes from one solution to another, to label analytes, to perform stringency and washing steps, and to probe biophysical properties of the analytes, distinguishing methodologies with fluid flow and without fluid flow (stationary microfluidics). Our review focuses on efforts to combine and integrate different magnetically actuated assay steps, with the vision that it will become possible in the future to realize integrated lab-on-chip biosensing assays in which all assay process steps are controlled and optimized by magnetic forces.

  4. Temperature sensing based on a Brillouin fiber microwave generator

    Science.gov (United States)

    Yang, X. P.; Gan, J. L.; Xu, S. H.; Yang, Z. M.

    2013-04-01

    We propose and demonstrate a novel dual-frequency Brillouin fiber laser used for microwave generation. Based on this configuration, temperature sensing has been realized. The dual-frequency Brillouin lasing is generated independently from two pieces of fiber cascaded within one ring resonator. Microwave generation is acquired as the beat signal of the dual-frequency Brillouin fiber laser, with the beat frequency being linearly proportional to the temperature difference of the two fiber sections. In the experiment, the temperature coefficient of frequency shift is 1.015 ± 0.001 MHz °C-1. The temperature can be precisely measured by acquiring the frequency of the microwave generator, and this new configuration provides a promising application for temperature sensing.

  5. Fine temporal control of the medium gas content and acidity and on-chip generation of series of oxygen concentrations for cell cultures.

    Science.gov (United States)

    Polinkovsky, Mark; Gutierrez, Edgar; Levchenko, Andre; Groisman, Alex

    2009-04-21

    We describe the design, operation, and applications of two microfluidic devices that generate series of concentrations of oxygen, [O(2)], by on-chip gas mixing. Both devices are made of polydimethylsiloxane (PDMS) and have two layers of channels, the flow layer and the gas layer. By using in-situ measurements of [O(2)] with an oxygen-sensitive fluorescent dye, we show that gas diffusion through PDMS leads to equilibration of [O(2)] in an aqueous solution in the flow layer with [O(2)] in a gas injected into the gas layer on a time scale of approximately 1 sec. Injection of carbon dioxide into the gas layer causes the pH in the flow layer to drop within approximately 0.5 sec. Gas-mixing channel networks of both devices generate series of 9 gas mixtures with different [O(2)] from two gases fed to the inlets, thus creating regions with 9 different [O(2)] in the flow layer. The first device generates nitrogen-oxygen mixtures with [O(2)] varying linearly between 0 and 100%. The second device generates nitrogen-air mixtures with [O(2)] varying exponentially between 0 and 20.9%. The flow layers of the devices are designed for culturing bacteria in semi-permeable microchambers, and the second device is used to measure growth curves of E. coli colonies at 9 different [O(2)] in a single experiment. The cell division rates at [O(2)] of 0, 0.2, and 0.5% are found to be significantly different, further validating the capacity of the device to set [O(2)] in the flow layer with high precision and resolution. The degree of control of [O(2)] achieved in the devices and the robustness with respect to oxygen consumption due to respiration would be difficult to match in a traditional large-scale culture. The proposed devices and technology can be used in research on bacteria and yeast under microaerobic conditions and on mammalian cells under hypoxia.

  6. Virtual microstructural leaf tissue generation based on cell growth modeling

    NARCIS (Netherlands)

    Abera, M.K.; Retta, M.A.; Verboven, P.; Nicolai, B.M.; Berghuijs, H.; Struik, P.

    2016-01-01

    A cell growth algorithm for virtual leaf tissue generation is presented based on the biomechanics of plant cells in tissues. The algorithm can account for typical differences in epidermal layers, palisade mesophyll layer and spongy mesophyll layer which have characteristic differences in the shap

  7. Balanced Civilization Map Generation based on Open Data

    DEFF Research Database (Denmark)

    Barros, Gabriella; Togelius, Julian

    2015-01-01

    This work investigates how to incorporate real-world data into game content so that the content is playable and enjoyable while not misrepresenting the data. We propose a method for generating balanced Civilization maps based on Open Data, describing how to acquire, transform and integrate...

  8. Separation of large DNA molecules by size exclusion chromatography-based microchip with on-chip concentration structure

    Science.gov (United States)

    Azuma, Naoki; Itoh, Shintaro; Fukuzawa, Kenji; Zhang, Hedong

    2016-06-01

    The separation of DNA molecules according to their size represents a fundamental bioanalytical procedure. Here, we report the development of a chip-sized device, consisting of micrometer-sized fence structures fabricated in a microchannel, for the separation of large DNA molecules (over 10 kbp) based on the principle of size exclusion chromatography (SEC). In order to achieve separation, two approaches were utilized: first, the DNA samples were concentrated immediately prior to separation using nanoslit structures, with the aim of improving the resolution. Second, a theoretical model of SEC-based separation was established and applied in order to predict the optimal voltage range for separation. In this study, we achieved separation of λ DNA (48.5 kbp) and T4 DNA (166 kbp) using the present SEC-based microchip.

  9. Generation of short electrical pulses based on bipolar transistorsny

    Directory of Open Access Journals (Sweden)

    M. Gerding

    2004-01-01

    Full Text Available A system for the generation of short electrical pulses based on the minority carrier charge storage and the step recovery effect of bipolar transistors is presented. Electrical pulses of about 90 ps up to 800 ps duration are generated with a maximum amplitude of approximately 7V at 50Ω. The bipolar transistor is driven into saturation and the base-collector and base-emitter junctions become forward biased. The resulting fast switch-off edge of the transistor’s output signal is the basis for the pulse generation. The fast switching of the transistor occurs as a result of the minority carriers that have been injected and stored across the base-collector junction under forward bias conditions. If the saturated transistor is suddenly reverse biased the pn-junction will appear as a low impedance until the stored charge is depleted. Then the impedance will suddenly increase to its normal high value and the flow of current through the junction will turn to zero, abruptly. A differentiation of the output signal of the transistor results in two short pulses with opposite polarities. The differentiating circuit is implemented by a transmission line network, which mainly acts as a high pass filter. Both the transistor technology (pnp or npn and the phase of the transfer function of the differentating circuit influence the polarity of the output pulses. The pulse duration depends on the transistor parameters as well as on the transfer function of the pulse shaping network. This way of generating short electrical pulses is a new alternative for conventional comb generators based on steprecovery diodes (SRD. Due to the three-terminal structure of the transistor the isolation problem between the input and the output signal of the transistor network is drastically simplified. Furthermore the transistor is an active element in contrast to a SRD, so that its current gain can be used to minimize the power of the driving signal.

  10. A Vector Network Analyzer Based on Pulse Generators

    Directory of Open Access Journals (Sweden)

    B. Schulte

    2005-01-01

    Full Text Available A fast four channel network analyzer is introduced to measure S-parameters in a frequency range from 10MHz to 3GHz. The signal generation for this kind of analyzer is based on pulse generators, which are realized with bipolar transistors. The output signal of the transistor is differentiated and two short pulses, a slow and a fast one, with opposite polarities are generated. The slow pulse is suppressed with a clipping network. Thus the generation of very short electrical pulses with a duration of about 100ps is possible. The structure of the following network analyzer is similar to the structure of a conventional four channel network analyzer. All four pulses, which contain the high frequency information of the device under test, are evaluated after the digitalization of intermediate frequencies. These intermediate frequencies are generated with sampling mixers. The recorded data is evaluated with a special analysis technique, which is based on a Fourier transformation. The calibration techniques used are the same as for conventional four channel network analyzers, no new calibration techniques need to be developed.

  11. Automatic Tamil lyric generation based on ontological interpretation for semantics

    Indian Academy of Sciences (India)

    Rajeswari Sridhar; D Jalin Gladis; Kameswaran Ganga; G Dhivya Prabha

    2014-02-01

    This system proposes an -gram based approach to automatic Tamil lyric generation, by the ontological semantic interpretation of the input scene. The approach is based on identifying the semantics conveyed in the scenario, thereby making the system understand the situation and generate lyrics accordingly. The heart of the system includes the ontological interpretation of the scenario, and the selection of the appropriate tri-grams for generating the lyrics. To fulfill this, we have designed a new ontology with weighted edges, where the edges correspond to a set of sentences, which indicate a relationship, and are represented as a tri-gram. Once the appropriate tri-grams are selected, the root words from these tri-grams are sent to the morphological generator, to form words in their packed form. These words are then assembled to form the final lyrics. Parameters of poetry like rhyme, alliteration, simile, vocative words, etc., are also taken care of by the system. Using this approach, we achieved an average accuracy of 77.3% with respect to the exact semantic details being conveyed in the generated lyrics.

  12. Enzymic colorimetry-based DNA chip: a rapid and accurate assay for detecting mutations for clarithromycin resistance in the 23S rRNA gene of Helicobacter pylori.

    Science.gov (United States)

    Xuan, Shi-Hai; Zhou, Yu-Gui; Shao, Bo; Cui, Ya-Lin; Li, Jian; Yin, Hong-Bo; Song, Xiao-Ping; Cong, Hui; Jing, Feng-Xiang; Jin, Qing-Hui; Wang, Hui-Min; Zhou, Jie

    2009-11-01

    Macrolide drugs, such as clarithromycin (CAM), are a key component of many combination therapies used to eradicate Helicobacter pylori. However, resistance to CAM is increasing in H. pylori and is becoming a serious problem in H. pylori eradication therapy. CAM resistance in H. pylori is mostly due to point mutations (A2142G/C, A2143G) in the peptidyltransferase-encoding region of the 23S rRNA gene. In this study an enzymic colorimetry-based DNA chip was developed to analyse single-nucleotide polymorphisms of the 23S rRNA gene to determine the prevalence of mutations in CAM-related resistance in H. pylori-positive patients. The results of the colorimetric DNA chip were confirmed by direct DNA sequencing. In 63 samples, the incidence of the A2143G mutation was 17.46 % (11/63). The results of the colorimetric DNA chip were concordant with DNA sequencing in 96.83 % of results (61/63). The colorimetric DNA chip could detect wild-type and mutant signals at every site, even at a DNA concentration of 1.53 x 10(2) copies microl(-1). Thus, the colorimetric DNA chip is a reliable assay for rapid and accurate detection of mutations in the 23S rRNA gene of H. pylori that lead to CAM-related resistance, directly from gastric tissues.

  13. Facile synthesis of Prussian blue nanocubes/silver nanowires network as a water-based ink for the direct screen-printed flexible biosensor chips.

    Science.gov (United States)

    Yang, Pengqi; Peng, Jingmeng; Chu, Zhenyu; Jiang, Danfeng; Jin, Wanqin

    2017-06-15

    The large-scale fabrication of nanocomposite based biosensors is always a challenge in the technology commercialization from laboratory to industry. In order to address this issue, we have designed a facile chemical method of fabricated nanocomposite ink applied to the screen-printed biosensor chip. This ink can be derived in the water through the in-situ growth of Prussian blue nanocubes (PBNCs) on the silver nanowires (AgNWs) to construct a composite nanostructure by a facile chemical method. Then a miniature flexible biosensor chip was screen-printed by using the prepared nanocomposite ink. Due to the synergic effects of the large specific surface area, high conductivity and electrocatalytic activity from AgNWs and PBNCs, the as-prepared biosensor chip exhibited a fast response (biosensor chip exhibited excellent stability, good reproducibility and high anti-interference ability towards physiological substances under a very low working potential of -0.05. Hence, the proposed biosensor chip also showed a promising potential for the application in practical analysis.

  14. Routing algorithms in networks-on-chip

    CERN Document Server

    Daneshtalab, Masoud

    2014-01-01

    This book provides a single-source reference to routing algorithms for Networks-on-Chip (NoCs), as well as in-depth discussions of advanced solutions applied to current and next generation, many core NoC-based Systems-on-Chip (SoCs). After a basic introduction to the NoC design paradigm and architectures, routing algorithms for NoC architectures are presented and discussed at all abstraction levels, from the algorithmic level to actual implementation.  Coverage emphasizes the role played by the routing algorithm and is organized around key problems affecting current and next generation, many-core SoCs. A selection of routing algorithms is included, specifically designed to address key issues faced by designers in the ultra-deep sub-micron (UDSM) era, including performance improvement, power, energy, and thermal issues, fault tolerance and reliability.   ·         Provides a comprehensive overview of routing algorithms for Networks-on-Chip and NoC-based, manycore systems; ·         Describe...

  15. Energy transfer phenomena and radiative processes in silicon nitride based materials for on-chip photonics applications

    Science.gov (United States)

    Li, Rui

    Rare-earth (RE) doping of silicon-based structures provides a valuable approach for light-emitting devices which could be monolithically integrated atop the widespread silicon electronics platform and enables inexpensive integration of on-chip optical components. However, the small excitable fraction of RE ions and the substantial free carrier losses in Si nanostructures severely limit the possibility to achieve net optical gain using traditional Er doped materials, such as Er doped Si-rich oxides (Er:SRO). On the other hand, a novel material platform based on RE-doped silicon nitride (RE:Six) materials has recently revealed unique advantages for on-chip light source. Based on a variety of light emission spectroscopic techniques and rate equation modeling, light emission and energy transfer phenomena were studied to quantitatively assess the benefits of the novel Er and Nd doped SiNx (Er: SiN x and Nd:SiNx) material platform compared to the standard Er:SRO. Efficient energy transfer and nanosecond-time dynamics from SiN x matrices to RE ions with two orders of magnitude larger coupling coefficient than Er:SRO were demonstrated for the first time. The origin of this energy transfer was shown to consist of non-resonant phonon-mediated coupling by temperature-dependent experiments. In addition, a tradeoff between excitation efficiency by energy transfer and emission efficiency, determined by excess Si concentration, was discovered and studied. Although carrier absorption and non-radiative recombination jeopardize the observation of optical gain, differential loss measurements under femtosecond pulsed excitation resulted in the bleaching of the Er ground state absorption by energy transfer in Er:SiN x materials, which bears great hope for the engineering of Si-based lasers. On the other hand, with a superior 4-level system, Nd:SiNx is promising to lase with a lower threshold. To make use of the better field confinement in SiNx due to its higher refractive index, RE

  16. A hearing aid on-chip system based on accuracy optimized front- and back-end blocks

    Science.gov (United States)

    Fanyang, Li; Hao, Jiang

    2014-03-01

    A hearing aid on-chip system based on accuracy optimized front- and back-end blocks is presented for enhancing the signal processing accuracy of the hearing aid. Compared with the conventional system, the accuracy optimized system is characterized by the dual feedback network and the gain compensation technique used in the front- and back-end blocks, respectively, so as to alleviate the nonlinearity distortion caused by the output swing. By using the technique, the accuracy of the whole hearing aid system can be significantly improved. The prototype chip has been designed with a 0.13 μm standard CMOS process and tested with 1 V supply voltage. The measurement results show that, for driving a 16 Ω loudspeaker with a normalized output level of 300 mVp-p, the total harmonic distortion reached about -60 dB, achieving at least three times reduction compared to the previously reported works. In addition, the typical input referred noise is only about 5 μVrms.

  17. A lab-on-chip cell-based biosensor for label-free sensing of water toxicants.

    Science.gov (United States)

    Liu, F; Nordin, A N; Li, F; Voiculescu, I

    2014-04-07

    This paper presents a lab-on-chip biosensor containing an enclosed fluidic cell culturing well seeded with live cells for rapid screening of toxicants in drinking water. The sensor is based on the innovative placement of the working electrode for the electrical cell-substrate impedance sensing (ECIS) technique as the top electrode of a quartz crystal microbalance (QCM) resonator. Cell damage induced by toxic water will cause a decrease in impedance, as well as an increase in the resonant frequency. For water toxicity tests, the biosensor's unique capabilities of performing two complementary measurements simultaneously (impedance and mass-sensing) will increase the accuracy of detection while decreasing the false-positive rate. Bovine aortic endothelial cells (BAECs) were used as toxicity sensing cells. The effects of the toxicants, ammonia, nicotine and aldicarb, on cells were monitored with both the QCM and the ECIS technique. The lab-on-chip was demonstrated to be sensitive to low concentrations of toxicants. The responses of BAECs to toxic samples occurred during the initial 5 to 20 minutes depending on the type of chemical and concentrations. Testing the multiparameter biosensor with aldicarb also demonstrated the hypothesis that using two different sensors to monitor the same cell monolayer provides cross validation and increases the accuracy of detection. For low concentrations of aldicarb, the variations in impedance measurements are insignificant in comparison with the shifts of resonant frequency monitored using the QCM resonator. A highly linear correlation between signal shifts and chemical concentrations was demonstrated for each toxicant.

  18. Bayesian-based aberration correction and numerical diffraction for improved lensfree on-chip microscopy of biological specimens

    CERN Document Server

    Wong, Alexander; Jin, Chao; Wang, Xiao Yu

    2015-01-01

    Lensfree on-chip microscopy is an emerging imaging technique that can be used to visualize and study biological specimens without the need for imaging lens systems. Important issues that can limit the performance of lensfree on-chip microscopy include interferometric aberrations, acquisition noise, and image reconstruction artifacts. In this study, we introduce a Bayesian-based method for performing aberration correction and numerical diffraction that accounts for all three of these issues to improve the effective numerical aperture (NA) and signal-to-noise ratio (SNR) of the reconstructed microscopic image. The proposed method was experimentally validated using the USAF resolution target as well as real waterborne Anabaena flos-aquae samples, demonstrating improvements in NA by ~25% over the standard method, and improvements in SNR of 2.3 dB and 3.8 dB in the reconstructed image when compared to the reconstructed images produced using the standard method and a maximum likelihood estimation method, respective...

  19. A wearable, low-power, health-monitoring instrumentation based on a Programmable System-on-Chip.

    Science.gov (United States)

    Massot, Bertrand; Gehin, Claudine; Nocua, Ronald; Dittmar, Andre; McAdams, Eric

    2009-01-01

    Improvement in quality and efficiency of health and medicine, at home and in hospital, has become of paramount importance. The solution of this problem would require the continuous monitoring of several key patient parameters, including the assessment of autonomic nervous system (ANS) activity using non-invasive sensors, providing information for emotional, sensorial, cognitive and physiological analysis of the patient. Recent advances in embedded systems, microelectronics, sensors and wireless networking enable the design of wearable systems capable of such advanced health monitoring. The subject of this article is an ambulatory system comprising a small wrist device connected to several sensors for the detection of the autonomic nervous system activity. It affords monitoring of skin resistance, skin temperature and heart activity. It is also capable of recording the data on a removable media or sending it to computer via a wireless communication. The wrist device is based on a Programmable System-on-Chip (PSoC) from Cypress: PSoCs are mixed-signal arrays, with dynamic, configurable digital and analogical blocks and an 8-bit Microcontroller unit (MCU) core on a single chip. In this paper we present first of all the hardware and software architecture of the device, and then results obtained from initial experiments.

  20. Poly(dimethylsiloxane) microchip-based immunoassay with multiple reaction zones: Toward on-chip multiplex detection platform

    Energy Technology Data Exchange (ETDEWEB)

    Shao, Guocheng; Wang, Jun; Li, Zhaohui; Saraf, Laxmikant V.; Wang, Wanjun; Lin, Yuehe

    2011-09-20

    In this work, a poly(dimethylsiloxane) (PDMS) microchip-based immuno-sensing platform with integrated pneumatic micro valves is described. The microchip was fabricated with multiple layer soft lithography technology. By controlling the activation status of corresponding valves, reagent flows in the microchannel network can be well manipulated so that immuno-reactions only take place at designated reaction zones (DRZs). Four DRZs are included in the prototype microchip. Since these DRZs are all isolated from each other by micro valves, cross contamination is prevented. Using the inner surface of the all-PDMS microchannel as immunoassay substrate, on-chip sandwich format solid phase immunoassay was performed to demonstrate the feasibility of this immuno-sensing platform. Mouse IgG and fluorescein isothiocyanate (FITC) were used as the model analyte and the signal reporter respectively. Only 10 ul sample is needed for the assay and low detection limit of 5 ng/ml (≈33 pM) was achieved though low-cost polyclonal antibodies were used in our experiment for feasibility study only. The encouraging results from mouse IgG immunoassay proved the feasibility of our microchip design. With slight modification of the assay protocol, the same chip design can be used for multi-target detection and can provide a simple, cost-effective and integrated microchip solution for multiplex immunoassay applications.

  1. Image analysis techniques associated with automatic data base generation.

    Science.gov (United States)

    Bond, A. D.; Ramapriyan, H. K.; Atkinson, R. J.; Hodges, B. C.; Thomas, D. T.

    1973-01-01

    This paper considers some basic problems relating to automatic data base generation from imagery, the primary emphasis being on fast and efficient automatic extraction of relevant pictorial information. Among the techniques discussed are recursive implementations of some particular types of filters which are much faster than FFT implementations, a 'sequential similarity detection' technique of implementing matched filters, and sequential linear classification of multispectral imagery. Several applications of the above techniques are presented including enhancement of underwater, aerial and radiographic imagery, detection and reconstruction of particular types of features in images, automatic picture registration and classification of multiband aerial photographs to generate thematic land use maps.

  2. All-optical pseudorandom bit sequences generator based on TOADs

    Science.gov (United States)

    Sun, Zhenchao; Wang, Zhi; Wu, Chongqing; Wang, Fu; Li, Qiang

    2016-03-01

    A scheme for all-optical pseudorandom bit sequences (PRBS) generator is demonstrated with optical logic gate 'XNOR' and all-optical wavelength converter based on cascaded Tera-Hertz Optical Asymmetric Demultiplexer (TOADs). Its feasibility is verified by generation of return-to-zero on-off keying (RZ-OOK) 263-1 PRBS at the speed of 1 Gb/s with 10% duty radio. The high randomness of ultra-long cycle PRBS is validated by successfully passing the standard benchmark test.

  3. Physical Unclonable Function (PUF) Based Random Number Generator

    CERN Document Server

    Sadr, Ali

    2012-01-01

    Physical Unclonable Functions (PUFs) are widely used to generate random Numbers. In this paper we propose a new architecture in which an Arbiter Based PUF has been employed as a nonlinear function in Nonlinear Feedback Shift Register (NFSR) to generate true random numbers. The rate of producing the output bit streams is 10 million bits per second. The proposed RNG is able to pass all NIST tests and the entropy of the output stream is 7.999837 bits per byte. The proposed circuit has very low resource usage of 193 Slices that makes it suitable for lightweight applications.

  4. New Metric Based Algorithm for Test Vector Generation in VLSI Testing

    Directory of Open Access Journals (Sweden)

    M. V. Atre

    1995-07-01

    Full Text Available A new algorithm for test-vector-generation (TVG for combinational circuits has been presented for testing VLSI chips. This is done by defining a suitable metric or distance, in the space of all input vectors, between a vector and a set of vectors. The test vectors are generated by suitably maximising the above distance. Two different methods of maximising the distance are suggested. Performances of the two methods for different circuits are presented and compared with the random method of TVG. It was observed that method B is superior to the other two methods. Also, method A is slightly better than method R.

  5. Picoliter Well Array Chip-Based Digital Recombinase Polymerase Amplification for Absolute Quantification of Nucleic Acids.

    Science.gov (United States)

    Li, Zhao; Liu, Yong; Wei, Qingquan; Liu, Yuanjie; Liu, Wenwen; Zhang, Xuelian; Yu, Yude

    2016-01-01

    Absolute, precise quantification methods expand the scope of nucleic acids research and have many practical applications. Digital polymerase chain reaction (dPCR) is a powerful method for nucleic acid detection and absolute quantification. However, it requires thermal cycling and accurate temperature control, which are difficult in resource-limited conditions. Accordingly, isothermal methods, such as recombinase polymerase amplification (RPA), are more attractive. We developed a picoliter well array (PWA) chip with 27,000 consistently sized picoliter reactions (314 pL) for isothermal DNA quantification using digital RPA (dRPA) at 39°C. Sample loading using a scraping liquid blade was simple, fast, and required small reagent volumes (i.e., PEG-silane agent effectively eliminated cross-contamination during dRPA. Our creative optical design enabled wide-field fluorescence imaging in situ and both end-point and real-time analyses of picoliter wells in a 6-cm(2) area. It was not necessary to use scan shooting and stitch serial small images together. Using this method, we quantified serial dilutions of a Listeria monocytogenes gDNA stock solution from 9 × 10(-1) to 4 × 10(-3) copies per well with an average error of less than 11% (N = 15). Overall dRPA-on-chip processing required less than 30 min, which was a 4-fold decrease compared to dPCR, requiring approximately 2 h. dRPA on the PWA chip provides a simple and highly sensitive method to quantify nucleic acids without thermal cycling or precise micropump/microvalve control. It has applications in fast field analysis and critical clinical diagnostics under resource-limited settings.

  6. Multiple-input multiple-output based high density on-chip optical interconnect

    Science.gov (United States)

    Shen, Po-Kuan; Xu, Xiaochuan; Hosseini, Amir; Pan, Zeyu; Chen, Ray T.

    2015-03-01

    In on-chip optical interconnect, dielectric waveguide arrays are usually designed with pitches of a few wavelengths to avoid crosstalk, which greatly limits the integration density. In this paper, we for the first time propose to use multipleinput multiple-output (MIMO), a well-known technique in wireless communication, to recover the data from entangled signals and reduce the waveguide pitch to subwavelength range. In the proposed on-chip MIMO system, there is significant coupling among the adjacent waveguides in the high density waveguide region. In order to recover signals, the N×N transmission matrix of N high-density waveguides is calculated to describe the relation between each input ports and output ports. In the receiving part, homodyne coherent receivers are used to receive the transmitted signals, and obtain the signal in phase and ?/2 out of phase with local oscillator. In the electrical signal processing, the inverse transmission matrix is utilized to recover the signals in the electronic domain. To verify the proposed on-chip MIMO, we used the INTERCONNECT package in Lumerical software to simulate a 10x10 MIMO system. The cross section of each waveguide is 500 nm x 220 nm. The spacing is 250 nm. The simulation verifies the possibility of recovering 10 Gbps data from the heavily coupled 10 waveguides with a BER better than 10-12. The minimum input optical power for a BER of 10-12 is greater than -18.1 dBm, and the maximum phase shift between input laser and local oscillator can reach to 73.5˚.

  7. Image-Based Geometric Modeling and Mesh Generation

    CERN Document Server

    2013-01-01

    As a new interdisciplinary research area, “image-based geometric modeling and mesh generation” integrates image processing, geometric modeling and mesh generation with finite element method (FEM) to solve problems in computational biomedicine, materials sciences and engineering. It is well known that FEM is currently well-developed and efficient, but mesh generation for complex geometries (e.g., the human body) still takes about 80% of the total analysis time and is the major obstacle to reduce the total computation time. It is mainly because none of the traditional approaches is sufficient to effectively construct finite element meshes for arbitrarily complicated domains, and generally a great deal of manual interaction is involved in mesh generation. This contributed volume, the first for such an interdisciplinary topic, collects the latest research by experts in this area. These papers cover a broad range of topics, including medical imaging, image alignment and segmentation, image-to-mesh conversion,...

  8. Chip scale mechanical spectrum analyzers based on high quality factor overmoded bulk acouslic wave resonators

    Energy Technology Data Exchange (ETDEWEB)

    Olsson, R. H., III

    2012-03-01

    The goal of this project was to develop high frequency quality factor (fQ) product acoustic resonators matched to a standard RF impedance of 50 {Omega} using overmoded bulk acoustic wave (BAW) resonators. These resonators are intended to serve as filters in a chip scale mechanical RF spectrum analyzer. Under this program different BAW resonator designs and materials were studied theoretically and experimentally. The effort resulted in a 3 GHz, 50 {Omega}, sapphire overmoded BAW with a fQ product of 8 x 10{sup 13}, among the highest values ever reported for an acoustic resonator.

  9. SNP typing on the NanoChip electronic microarray

    DEFF Research Database (Denmark)

    Børsting, Claus; Sanchez Sanchez, Juan Jose; Morling, Niels

    2005-01-01

    We describe a single nucleotide polymorphism (SNP) typing protocol developed for the NanoChip electronic microarray. The NanoChip array consists of 100 electrodes covered by a thin hydrogel layer containing streptavidin. An electric currency can be applied to one, several, or all electrodes...... at the same time according to a loading protocol generated by the user. Biotinylated deoxyribonucleic acid (DNA) is directed to the pad(s) via the electronic field(s) and bound to streptavidin in the hydrogel layer. Subsequently, fluorescently labeled reporter oligos and a stabilizer oligo are hybridized...... to the bound DNA. Base stacking between the short reporter and the longer stabilizer oligo stabilizes the binding of a matching reporter, whereas the binding of a reporter carrying a mismatch in the SNP position will be relatively weak. Thermal stringency is applied to the NanoChip array according to a reader...

  10. Generators of the auxiliary signals based on the Josephson junctions

    Directory of Open Access Journals (Sweden)

    V. M. Kychak

    2014-06-01

    Full Text Available Introduction and problem statement. Generators based on the Josephson junctions are advisable to use to ensure the generation of signals in the wavelength range from infrared to millimeter. It is necessary to build a dependence of the phase difference of the wave functions superconductor Josephson junctions from the parameters of the equivalent circuit of the resistive shunted tunnel junction. Solution of the problem. An analytical expression for calculating the dependence of the instantaneous voltage values from the parameters of the equivalent circuit resistive shunted Josephson junction is obtained. The dependence of the oscillation period from the parameters of the equivalent circuit elements is researched and a comparison of its values with the period of the output voltage of the generator based on three Josephson junctions is carried out. Conclusions. It is shown that the synchronization leads to decrement in the line width generation and increment the output voltage. Comparison of theoretical calculations and computer modeling shows that the differences do not exceed 25% and therefore they can be used for approximate calculations.

  11. Elliptic grid generation based on Laplace equations and algebraic transformations

    Energy Technology Data Exchange (ETDEWEB)

    Spekreuse, S.P. [National Aerospace Lab., Amsterdam (Netherlands)

    1995-04-01

    An elliptic grid generation method is presented to generate boundary conforming grids in domains in 2D and 3D physical space and on minimal surfaces and parametrized surfaces in 3D physical space. The elliptic grid generation method is based on the use of a composite mapping. This composite mapping consists of a nonlinear transfinite algebraic transformation and an elliptic transformation. The elliptic transformation is based on the Laplace equations for domains, or on the Laplace-Beltrami equations for surfaces. The algebraic transformation maps the computational space one to-one onto a parameter space. The elliptic transformation maps the parameter space one-to-one onto the domains or surfaces. The composition of these two mapping is a differentiable one-to-one mapping from computational space onto the domains or surfaces and has a nonvanishing Jacobian. This composite mapping defines the grid point distribution in the interior of the domains or surfaces. For domains and minimal surfaces, the composite mapping obeys a nonlinear elliptic Poisson system with control functions completely defined by the algebraic transformation. The solution of the Poisson systems is obtained by Picard iteration and black-box multigrid solvers. For parametrized curved surfaces, it is not necessary to define and solve a nonlinear elliptic Poisson system. Instead a linear elliptic system and an inversion problem is solved to generate the grid in the interior of the surface.

  12. Modeling and Simulation of Generator Side Converter of Doubly Fed Induction Generator-Based Wind Power Generation System

    DEFF Research Database (Denmark)

    Guo, Yougui; Zeng, Ping; Blaabjerg, Frede

    2010-01-01

    A real wind power generation system is given in this paper. SVM control strategy and vector control is applied for generator side converter and doubly fed induction generator respectively. First the mathematical models of the wind turbine rotor, drive train, generator side converter are described...

  13. Providing content based billing architecture over Next Generation Network

    CERN Document Server

    Lakhtaria, Kamaljit I

    2010-01-01

    Mobile Communication marketplace has stressed that "content is king" ever since the initial footsteps for Next Generation Networks like 3G, 3GPP, IP Multimedia subsystem (IMS) services. However, many carriers and content providers have struggled to drive revenue for content services, primarily due to current limitations of certain types of desirable content offerings, simplistic billing models, and the inability to support flexible pricing, charging and settlement. Unlike wire line carriers, wireless carriers have a limit to the volume of traffic they can carry, bounded by the finite wireless spectrum. Event based services like calling, conferencing etc., only perceive charge per event, while the Content based charging system attracts Mobile Network Operators (MNOs) to maximize service delivery to customer and achieve best ARPU. With the Next Generation Networks, the number of data related services that can be offered, is increased significantly. The wireless carrier will be able to move from offering wireles...

  14. Generating a multilingual taxonomy based on multilingual terminology clustering

    Institute of Scientific and Technical Information of China (English)

    Chengzhi; ZHANG

    2011-01-01

    Taxonomy denotes the hierarchical structure of a knowledge organization system.It has important applications in knowledge navigation,semantic annotation and semantic search.It is a useful instrument to study the multilingual taxonomy generated automatically under the dynamic information environment in which massive amounts of information are processed and found.Multilingual taxonomy is the core component of the multilingual thesaurus or ontology.This paper presents two methods of bilingual generated taxonomy:Cross-language terminology clustering and mixed-language based terminology clustering.According to our experimental results of terminology clustering related to four specific subject domains,we found that if the parallel corpus is used to cluster multilingual terminologies,the method of using mixed-language based terminology clustering outperforms that of using the cross-language terminology clustering.

  15. Implementing oxygen control in chip-based cell and tissue culture systems.

    Science.gov (United States)

    Oomen, Pieter E; Skolimowski, Maciej D; Verpoorte, Elisabeth

    2016-09-21

    Oxygen is essential in the energy metabolism of cells, as well as being an important regulatory parameter influencing cell differentiation and function. Interest in precise oxygen control for in vitro cultures of tissues and cells continues to grow, especially with the emergence of the organ-on-a-chip and the desire to emulate in vivo conditions. This was recently discussed in this journal in a Critical Review by Brennan et al. (Lab Chip (2014). DOI: ). Microfluidics can be used to introduce flow to facilitate nutrient supply to and waste removal from in vitro culture systems. Well-defined oxygen gradients can also be established. However, cells can quickly alter the oxygen balance in their vicinity. In this Tutorial Review, we expand on the Brennan paper to focus on the implementation of oxygen analysis in these systems to achieve continuous monitoring. Both electrochemical and optical approaches for the integration of oxygen monitoring in microfluidic tissue and cell culture systems will be discussed. Differences in oxygen requirements from one organ to the next are a challenging problem, as oxygen delivery is limited by its uptake into medium. Hence, we discuss the factors determining oxygen concentrations in solutions and consider the possible use of artificial oxygen carriers to increase dissolved oxygen concentrations. The selection of device material for applications requiring precise oxygen control is discussed in detail, focusing on oxygen permeability. Lastly, a variety of devices is presented, showing the diversity of approaches that can be employed to control and monitor oxygen concentrations in in vitro experiments.

  16. Compact Shorted Stacked-Patch Antenna Integrated with Chip-Package Based on LTCC Technology

    Directory of Open Access Journals (Sweden)

    Yongjiu Li

    2014-01-01

    Full Text Available A low profile chip-package stacked-patch antenna is proposed by using low temperature cofired ceramic (LTCC technology. The proposed antenna employs a stacked-patch to achieve two operating frequency bands and enhance the bandwidth. The height of the antenna is decreased to 4.09 mm (about λ/25 at 2.45 GHz due to the shorted pin. The package is mounted on a 44 × 44 mm2 ground plane to miniaturize the volume of the system. The design parameters of the antenna and the effect of the antenna on chip-package cavity are carefully analyzed. The designed antenna operates at a center frequency of 2.45 GHz and its impedance bandwidth (S11< -10 dB is 200 MHz, resulting from two neighboring resonant frequencies at 2.41 and 2.51 GHz, respectively. The average gain across the frequency band is about 5.28 dBi.

  17. AN FFT-BASED SELF-SIMILAR TRAFFIC GENERATOR

    Institute of Scientific and Technical Information of China (English)

    施建俊; 薛质; 诸鸿文

    2001-01-01

    The self-similarity of the network traffic has great influences on the performance. But there are few analytical or even numerical solutions for such a model. So simulation becomes the most efficient method for research. Fractal Gaussian noise (FGN) is the most popularly used self-similar model. This paper presented an FGN generator based on fast Fourier transform (FFT). The study indicates that this algorithm is fairly fast and accurate.

  18. Audio Signal Generator System Based On State Machines

    Institute of Scientific and Technical Information of China (English)

    王维喜

    2009-01-01

    A state machine can make program designing quicker, simpler and more efficient. This paper describes in detail the model for a state machine and the idea for its designing and gives the design process of the state machine through an example of audio signal generator system based on Labview. The result shows that the introduction of the state machine can make complex design processes more clear and the revision of programs easier.

  19. Control System for a Diesel Generator and UPS Based Microgrid

    OpenAIRE

    Palamar, A; Pettai, E; Beldjajev, v

    2010-01-01

    In this paper a microgrid composed of a diesel generator and two uninterruptible power supply systems with separate battery banks is introduced. The microgrid located in three academic buildings of Tallinn University of Technology. A three-level control and monitoring system for the microgrid based on the EtherNet/IP communication network is developed. In addition, a control strategy of the microgrid in the grid-connected and stand-alone mode of operation is proposed

  20. SABATPG-A Structural Analysis Based Automatic Test Generation System

    Institute of Scientific and Technical Information of China (English)

    李忠诚; 潘榆奇; 闵应骅

    1994-01-01

    A TPG system, SABATPG, is given based on a generic structural model of large circuits. Three techniques of partial implication, aftereffect of identified undetectable faults and shared sensitization with new concepts of localization and aftereffect are employed in the system to improve FAN algorithm. Experiments for the 10 ISCAS benchmark circuits show that the computing time of SABATPG for test generation is 19.42% less than that of FAN algorithm.

  1. Spin-torque generation in topological insulator based heterostructures

    KAUST Repository

    Fischer, Mark H.

    2016-03-11

    Heterostructures utilizing topological insulators exhibit a remarkable spin-torque efficiency. However, the exact origin of the strong torque, in particular whether it stems from the spin-momentum locking of the topological surface states or rather from spin-Hall physics of the topological-insulator bulk, remains unclear. Here, we explore a mechanism of spin-torque generation purely based on the topological surface states. We consider topological-insulator-based bilayers involving ferromagnetic metal (TI/FM) and magnetically doped topological insulators (TI/mdTI), respectively. By ascribing the key theoretical differences between the two setups to location and number of active surface states, we describe both setups within the same framework of spin diffusion of the nonequilibrium spin density of the topological surface states. For the TI/FM bilayer, we find large spin-torque efficiencies of roughly equal magnitude for both in-plane and out-of-plane spin torques. For the TI/mdTI bilayer, we elucidate the dominance of the spin-transfer-like torque. However, we cannot explain the orders of magnitude enhancement reported. Nevertheless, our model gives an intuitive picture of spin-torque generation in topological-insulator-based bilayers and provides theoretical constraints on spin-torque generation due to topological surface states.

  2. An artificially generated atmosphere near a lunar base

    Science.gov (United States)

    Burns, Jack O.; Fernini, Ilias; Sulkanen, Martin; Duric, Nebojsa; Taylor, G. Jeffrey; Johnson, Stewart W.

    1992-09-01

    We discuss the formation of an artificial atmosphere generated by vigorous lunar base activity in this paper. We developed an analytical, steady-state model for a lunar atmosphere based upon previous investigations of the Moon's atmosphere from Apollo. Constant gas-injection rates, ballistic trajectories, and a Maxwellian particle distribution for an oxygen-like gas are assumed. Even for the extreme case of continuous He-3 mining of the lunar regolith, we find that the lunar atmosphere would not significantly degrade astronomical observations beyond about 10 km from the mining operation.

  3. Microelectromechanical system-based electrochemical seismic sensors with an anode and a cathode integrated on one chip

    Science.gov (United States)

    Deng, T.; Sun, Z.; Li, G.; Chen, J.; Chen, D.; Wang, J.

    2017-02-01

    This paper presents a microelectromechanical system (MEMS)-based electrochemical seismic sensor with an anode and a cathode integrated on a single chip. The proposed approach decreases the number of requested wafers as the sensing unit from seven to two. In addition, no alignment and no bonding among the electrodes are needed, significantly simplifying the fabrication process. The experimental results indicate that the proposed device produced a sensitivity of 5771.7 V (m s-1)-1 at 1.4 Hz and a noise level of  -163 dB (i.e. 7.1 (nm s-1)/Hz1/2) at 1 Hz. Moreover, the proposed device effectively responds to random ground motions, enabling the detection of low-frequency seismic motions caused by earthquake events.

  4. Capillary-driven microfluidic paper-based analytical devices for lab on a chip screening of explosive residues in soil.

    Science.gov (United States)

    Ueland, Maiken; Blanes, Lucas; Taudte, Regina V; Stuart, Barbara H; Cole, Nerida; Willis, Peter; Roux, Claude; Doble, Philip

    2016-03-04

    A novel microfluidic paper-based analytical device (μPAD) was designed to filter, extract, and pre-concentrate explosives from soil for direct analysis by a lab on a chip (LOC) device. The explosives were extracted via immersion of wax-printed μPADs directly into methanol soil suspensions for 10min, whereby dissolved explosives travelled upwards into the μPAD circular sampling reservoir. A chad was punched from the sampling reservoir and inserted into a LOC well containing the separation buffer for direct analysis, avoiding any further extraction step. Eight target explosives were separated and identified by fluorescence quenching. The minimum detectable amounts for all eight explosives were between 1.4 and 5.6ng with recoveries ranging from 53-82% from the paper chad, and 12-40% from soil. This method provides a robust and simple extraction method for rapid identification of explosives in complex soil samples.

  5. Microfluidic Chip-based Nucleic Acid Testing using Gingival Crevicular Fluid as a New Technique for Detecting HIV-1 Infection

    Directory of Open Access Journals (Sweden)

    Alex Willyandre

    2013-05-01

    Full Text Available Transmission of HIV-1 infection by individuals in window period who are tested negative in conventional HIV-1 detection would pose the community with serious problems. Several diagnostic tools require specific labora-tory equipment, perfect timing of diagnosis, antibody to HIV-1, and invasive technique to get sample for examination, until high amount of time to process the sample as well as accessibility of remote areas. Many attempts have been made to solve those problems to come to a new detection technique. This review aims to give information about the current development technique for detection of HIV infection. Microfluidic Chip-based Nucleic Acid Testing is currently introduced for detection of HIV-1 infection. This review also cover the possible usage of gingival crevicular fluid as sample specimen that could be taken noninvasively from the individual.DOI: 10.14693/jdi.v18i2.63

  6. Agent Based Control of Electric Power Systems with Distributed Generation

    DEFF Research Database (Denmark)

    Saleem, Arshad

    . The methodology consists of suggestions for redesign of control architecture, a prototype for a software platform which facilitates implementation of multiagent control and results from case studies of specic scenarios. The work also contributes to agent based control with an approach of model based agents....... This thesis focuses on making a systematic evaluation of using intelligent software agent technology for control of electric power systems with high penetration of distributed generation. The thesis is based upon a requirement driven approach. It starts with investigating new trends and challenges in Electric...... agents. It suggests a multiagent based exible control architecture (subgrid control) suitable for the implementation of the innovative control concepts. This subgrid control architecture is tested on a novel distributed software platform which has been developed to design, test and evaluate distributed...

  7. Random Number Generation for High Performance Computing

    Science.gov (United States)

    2015-01-01

    including Gnu Scientific Library, gsl 5 package). SFMT19937, a parallel 128-bit version, and MTGP, a GPU version as part of NVIDIA CUDA library, are also...context-free generator, a CPU-based context-aware generator, and GPU -based context-free generator. (a) Papers published in peer-reviewed journals (N/A for...generator (DRNG) and Nvidia’s GPU -based generator MTGP32 [6], when the host system has the necessary hardware—newer processor chips or GPUs

  8. Experience of pico/micro hydro based power generation

    Energy Technology Data Exchange (ETDEWEB)

    Murthy, S.S. [Indian Inst. of Technology, Delhi, New Delhi (India). Dept. of Electrical Engineering

    2010-07-01

    Although India has approximately 150,000 megawatts of hydro potential, only a small portion is tapped. There is also significant untapped hydro potential in many developing countries such as Nepal, Bhutan, Vietnam, Indonesia and regions in South America and Africa. Small-scale hydroelectric power systems with capacities of up to a few megawatts are eco-friendly and sustainable. They can be classified based on unit sizes as pico (u pto 10 kilowatts), micro (10-100 kilowatts) and mini (100 kilowatts to a few megawatts) hydro systems. Mini hydro systems are always grid connected while micro can be either grid connected or off grid. Pico is always off grid. In India, there are thousands of favorable sites in this range that should be tapped for distributed power generation to electrify local communities. This need is reflected by the global emphasis on distributed power generation as well as the Government of India's policy to promote this type of power generation. A working stand alone pico-hydro power generating system has been successfully installed in 5 sites in Karnataka. The purpose of the project was to demonstrate the technical, managerial and economic feasibility of setting up small hydro projects in remote hilly areas of Karnataka, India and its positive environmental impact. The presentation discussed the site selection criteria; installed sites of pico hydro; system description; parts of the system; the electric load controller; types of electronic load controllers; and a description of the unit and control scheme. tabs., figs.

  9. Parametric down-conversion photon pair source on a nanophotonic chip

    CERN Document Server

    Guo, Xiang; Schuck, Carsten; Jung, Hojoong; Cheng, Risheng; Tang, Hong X

    2016-01-01

    Quantum photonic chips, which integrate quantum light sources alongside active and passive optical elements, as well as single photon detectors, show great potential for photonic quantum information processing and quantum technology. Mature semiconductor nanofabrication processes allow for scaling such photonic integrated circuits to on-chip networks of increasing complexity. Second order nonlinear materials are the method of choice for generating photonic quantum states in the overwhelming part of linear optic experiments using bulk components but integration with waveguide circuitry on a nanophotonic chip proved to be challenging. Here we demonstrate such an on-chip parametric down-conversion source of photon pairs based on second order nonlinearity in an Aluminum nitride microring resonator. We show the potential of our source for quantum information processing by measuring high-visibility antibunching of heralded single photons with nearly ideal state purity. Our down conversion source operates with high ...

  10. Reusable and mediator-free cholesterol biosensor based on cholesterol oxidase immobilized onto TGA-SAM modified smart bio-chips.

    Science.gov (United States)

    Rahman, Mohammed M

    2014-01-01

    A reusable and mediator-free cholesterol biosensor based on cholesterol oxidase (ChOx) was fabricated based on self-assembled monolayer (SAM) of thioglycolic acid (TGA) (covalent enzyme immobilization by dropping method) using bio-chips. Cholesterol was detected with modified bio-chip (Gold/Thioglycolic-acid/Cholesterol-oxidase i.e., Au/TGA/ChOx) by reliable cyclic voltammetric (CV) technique at room conditions. The Au/TGA/ChOx modified bio-chip sensor demonstrates good linearity (1.0 nM to 1.0 mM; R = 0.9935), low-detection limit (∼0.42 nM, SNR∼3), and higher sensitivity (∼74.3 µA µM(-1) cm(-2)), lowest-small sample volume (50.0 μL), good stability, and reproducibility. To the best of our knowledge, this is the first statement with a very high sensitivity, low-detection limit, and low-sample volumes are required for cholesterol biosensor using Au/TGA/ChOx-chips assembly. The result of this facile approach was investigated for the biomedical applications for real samples at room conditions with significant assembly (Au/TGA/ChOx) towards the development of selected cholesterol biosensors, which can offer analytical access to a large group of enzymes for wide range of biomedical applications in health-care fields.

  11. Generation of tunable, high repetition rate frequency combs with equalized spectra using carrier injection based silicon modulators

    Science.gov (United States)

    Nagarjun, K. P.; Selvaraja, Shankar Kumar; Supradeepa, V. R.

    2016-03-01

    High repetition-rate frequency combs with tunable repetition rate and carrier frequency are extensively used in areas like Optical communications, Microwave Photonics and Metrology. A common technique for their generation is strong phase modulation of a CW-laser. This is commonly implemented using Lithium-Niobate based modulators. With phase modulation alone, the combs have poor spectral flatness and significant number of missing lines. To overcome this, a complex cascade of multiple intensity and phase modulators are used. A comb generator on Silicon based on these principles is desirable to enable on-chip integration with other functionalities while reducing power consumption and footprint. In this work, we analyse frequency comb generation in carrier injection based Silicon modulators. We observe an interesting effect in these comb generators. Enhanced absorption accompanying carrier injection, an undesirable effect in data modulators, shapes the amplitude here to enable high quality combs from a single modulator. Thus, along with reduced power consumption to generate a specific number of lines, the complexity has also been significantly reduced. We use a drift-diffusion solver and mode solver (Silvaco TCAD) along with Soref-Bennett relations to calculate the variations in refractive indices and absorption of an optimized Silicon PIN - waveguide modulator driven by an unbiased high frequency (10 Ghz) voltage signal. Our simulations demonstrate that with a device length of 1 cm, a driving voltage of 2V and minor shaping with a passive ring-resonator filter, we obtain 37 lines with a flatness better than 5-dB across the band and power consumption an order of magnitude smaller than Lithium-Niobate modulators.

  12. Bead-based immunoassays using a micro-chip flow cytometer.

    Science.gov (United States)

    Holmes, David; She, Joseph K; Roach, Peter L; Morgan, Hywel

    2007-08-01

    A microfabricated flow cytometer has been developed for the analysis of micron-sized polymer beads onto which fluorescently labelled proteins have been immobilised. Fluorescence measurements were made on the beads as they flowed through the chip. Binding of antibodies to surface-immobilised antigens was quantitatively assayed using the device. Particles were focused through a detection zone in the centre of the flow channel using negative dielectrophoresis. Impedance measurements of the particles (at 703 kHz) were used to determine particle size and to trigger capture of the fluorescence signal. Antibody binding was measured by fluorescence at single and dual excitation wavelengths (532 nm and 633 nm). Fluorescence compensation techniques were implemented to correct for spectral overspill between optical detection channels. The data from the microfabricated flow cytometer was shown to be comparable to that of a commercial flow cytometer (BD-FACSAria).

  13. Chalcogenide glass planar MIR couplers for future chip based Bracewell interferometers

    CERN Document Server

    Goldsmith, Harry-Dean Kenchington; Ireland, Michael; Ma, Pan; Tuthill, Peter; Eggleton, Ben; Lawrence, John S; Debbarma, Sukanta; Luther-Davies, Barry; Madden, Stephen J

    2016-01-01

    Photonic integrated circuits are established as the technique of choice for a number of astronomical processing functions due to their compactness, high level of integration, low losses, and stability. Temperature control, mechanical vibration and acoustic noise become controllable for such a device enabling much more complex processing than can realistically be considered with bulk optics. To date the benefits have mainly been at wavelengths around 1550 nm but in the important Mid-Infrared region, standard photonic chips absorb light strongly. Chalcogenide glasses are well known for their transparency to beyond 10000 nm, and the first results from coupler devices intended for use in an interferometric nuller for exoplanetary observation in the Mid-Infrared L band (3800-4200 nm) are presented here showing that suitable performance can be obtained both theoretically and experimentally for the first fabricated devices operating at 4000 nm.

  14. Large-field-of-view Chip-scale Talbot-grid-based Fluorescence Microscopy

    CERN Document Server

    Pang, Shuo; Kato, Mihoko; Sternberg, Paul W; Yang, Changhuei

    2012-01-01

    The fluorescence microscope is one of the most important tools in modern clinical diagnosis and biological science. However, its expense, size and limited field-of-view (FOV) are becoming bottlenecks in key applications such as large-scale phenotyping and low-resource-setting diagnostics. Here we report a low-cost, compact chip-scale fluorescence-imaging platform, termed the Fluorescence Talbot Microscopy (FTM), which utilizes the Talbot self-imaging effect to enable efficient fluorescence imaging over a large and directly-scalable FOV. The FTM prototype has a resolution of 1.2 microns and an FOV of 3.9 mm x 3.5 mm. We demonstrate the imaging capability of FTM on fluorescently labeled breast cancer cells (SK-BR-3) and HEK cells expressing green fluorescent protein.

  15. Silicon Based Solid Oxide Fuel Cell Chip for Portable Consumer Electronics -- Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Alan Ludwiszewski

    2009-06-29

    LSI’s fuel cell uses efficient Solid Oxide Fuel Cell (“SOFC”) technology, is manufactured using Micro Electrical Mechanical System (“MEMS”) fabrication methods, and runs on high energy fuels, such as butane and ethanol. The company’s Fuel Cell on a Chip™ technology enables a form-factor battery replacement for portable electronic devices that has the potential to provide an order-of-magnitude run-time improvement over current batteries. Further, the technology is clean and environmentally-friendly. This Department of Energy funded project focused on accelerating the commercialization and market introduction of this technology through improvements in fuel cell chip power output, lifetime, and manufacturability.

  16. Interfacial tension based on-chip extraction of microparticles confined in microfluidic Stokes flows

    Science.gov (United States)

    Huang, Haishui; He, Xiaoming

    2014-10-01

    Microfluidics involving two immiscible fluids (oil and water) has been increasingly used to produce hydrogel microparticles with wide applications. However, it is difficult to extract the microparticles out of the microfluidic Stokes flows of oil that have a Reynolds number (the ratio of inertia to viscous force) much less than one, where the dominant viscous force tends to drive the microparticles to move together with the surrounding oil. Here, we present a passive method for extracting hydrogel microparticles in microfluidic Stokes flow from oil into aqueous extracting solution on-chip by utilizing the intrinsic interfacial tension between oil and the microparticles. We further reveal that the thickness of an "extended confining layer" of oil next to the interface between oil and aqueous extracting solution must be smaller than the radius of microparticles for effective extraction. This method uses a simple planar merging microchannel design that can be readily fabricated and further integrated into a fluidic system to extract microparticles for wide applications.

  17. Z - Source Multi Level Inverter Based PV Generation System

    Directory of Open Access Journals (Sweden)

    T. Lakhmi kanth

    2014-09-01

    Full Text Available In this paper a novel technique of Z-Source multilevel Inverter based PV Generation system is implemented and simulated using MATLAB-Simulink simulation software. The Photovoltaic cells are healthier option for converting solar energy into electricity. Due to high capital cost and low efficiency PV cells have not yet been a fully smart choice for electricity users. To enhance the performance of the system, Z-Source multi level inverter can be used in place of conventional Voltage Source Inverter (VSI in Solar Power Generation System. The PV cell model is developed using circuit mathematical equations. The Z-Source multilevel inverter is modeled to realize boosted DC to AC conversion (inversion with low THD. Outcome shows that the energy conversion efficiency of ZSMLI is a lot improved as compared to conventional voltage Source Inverter (VSI. By doing FFT analysis we can know the total THD.

  18. Assembly, chip and method of operating

    NARCIS (Netherlands)

    Reefman, D.; Roozeboom, F.; Klootwijk, J.H.

    2012-01-01

    The chip comprises a network of trench capacitors and an inductor, wherein the trench capacitors are coupled in parallel with a pattern of interconnects that is designed so as to limit generation of eddy current induced by the inductor in the interconnects. This allows the use of the chip as a porti

  19. Fiber‐free coupling between bulk laser beams and on‐chip polymer‐based multimode waveguides

    DEFF Research Database (Denmark)

    Jensen, Thomas Glasdam; Nielsen, Lars Bue; Kutter, Jörg Peter

    2011-01-01

    In this paper, we demonstrate the design of a virtually alignment‐free optical setup for use with microfluidic applications involving a layered glass/SU‐8/PDMS (polydimethylsiloxane) chip. We show how inexpensive external lenses combined with carefully designed on‐chip lenses can be used to couple...

  20. Image Relaxation Matching Based on Feature Points for DSM Generation

    Institute of Scientific and Technical Information of China (English)

    ZHENG Shunyi; ZHANG Zuxun; ZHANG Jianqing

    2004-01-01

    In photogrammetry and remote sensing, image matching is a basic and crucial process for automatic DEM generation. In this paper we presented a image relaxation matching method based on feature points. This method can be considered as an extention of regular grid point based matching. It avoids the shortcome of grid point based matching. For example, with this method, we can avoid low or even no texture area where errors frequently appear in cross correlaton matching. In the mean while, it makes full use of some mature techniques such as probability relaxation, image pyramid and the like which have already been successfully used in grid point matching process. Application of the technique to DEM generaton in different regions proved that it is more reasonable and reliable.

  1. Chips 2020

    CERN Document Server

    2016-01-01

    The release of this second volume of CHIPS 2020 coincides with the 50th anniversary of Moore’s Law, a critical year marked by the end of the nanometer roadmap and by a significantly reduced annual rise in chip performance. At the same time, we are witnessing a data explosion in the Internet, which is consuming 40% more electrical power every year, leading to fears of a major blackout of the Internet by 2020. The messages of the first CHIPS 2020, published in 2012, concerned the realization of quantum steps for improving the energy efficiency of all chip functions. With this second volume, we review these messages and amplify upon the most promising directions: ultra-low-voltage electronics, nanoscale monolithic 3D integration, relevant-data, brain- and human-vision-inspired processing, and energy harvesting for chip autonomy. The team of authors, enlarged by more world leaders in low-power, monolithic 3D, video, and Silicon brains, presents new vistas in nanoelectronics, promising  Moore-like exponential g...

  2. Rapid fabrication of a four-layer PMMA-based microfluidic chip using CO2-laser micromachining and thermal bonding

    Science.gov (United States)

    Chen, Xueye; Shen, Jienan; Zhou, Mengde

    2016-10-01

    A smart design method to transform the original two-layer microfluidic chip into a four-layer 3D microfluidic chip is proposed. A novel fabrication method is established to rapidly and effectively produce a four-layer microfluidic chip device made entirely from polymethylmethacrylate (PMMA). Firstly, the CO2-laser cuts the PMMA sheets by melting and blowing away vaporized material from the parent material to obtain high-quality channels of the microfluidic chip. An orthogonal experimental method is used to study its processing stability. In addition, a simple, rapid thermal bonding technique is successfully applied in fabricating the four-layer microfluidic chip, which has a bond strength of 1.3 MPa. A wooden pole is used to improve the accuracy of the alignment. Finally, a mixing experiment with blue ink and water is carried out, which proves that this smart design method and rapid manufacturing technology are successful.

  3. Microfluidic chip based micro RNA detection through the combination of fluorescence and surface enhanced Raman scattering techniques

    Science.gov (United States)

    Wang, Zhile; Zong, Shenfei; Wang, Zhuyuan; Wu, Lei; Chen, Peng; Yun, Binfeng; Cui, Yiping

    2017-03-01

    We present a novel microfluidic chip based method for the detection of micro RNA (miRNA) via the combination of fluorescence and surface enhanced Raman scattering (SERS) spectroscopies. First, silver nanoparticles (Ag NPs) are immobilized onto a glass slide, forming a SERS enhancing substrate. Then a specificially designed molecular beacon (MB) is attached to the SERS substrate. The 3‧ end of the MB is decorated with a thiol group to facilitate the attachment of the MB, while the 5‧ end of the MB is labeled with an organic dye 6-FAM, which is used both as the fluorophore and SERS reporter. In the absence of target miRNA, the MB will form a hairpin structure, making 6-FAM close to the Ag NPs. Hence, the fluorescence of 6-FAM will be quenched and the Raman signal of 6-FAM will be enhanced. On the contrary, with target miRNA present, hybridization between the miRNA and MB will unfold the MB and increase the distance between 6-FAM and the Ag NPs. Thus the fluorescence of 6-FAM will recover and the SERS signal of 6-FAM will decrease. So the target miRNA will simultaneously introduce opposite changing trends in the intensities of the fluorescence and SERS signals. By combining the opposite changes in the two optical spectra, an improved sensitivity and linearity toward the target miRNA is achieved as compared with using solely fluorescence or SERS. Moreover, introducing the microfluidic chip can reduce the reaction time, reagent dosage and complexity of detection. With the improved sensitivity and simplicity, we anticipate that the presented method can have great potential in the investigation of miRNA related diseases.

  4. An agent-based multi-scale wind generation model

    Energy Technology Data Exchange (ETDEWEB)

    Kremers, E.; Lewald, N. [Karlsruhe Univ., Karlsruhe (Germany). European Inst. for Energy Research; Barambones, O.; Gonzalez de Durana, J.M. [Univ. of the Basque Country, Vitoria (Spain). Dept. of Engineering

    2009-07-01

    The introduction of renewable energies, the liberalization of energy markets and the emergence of new, distributed producers that feed into the grid at almost every level of the system have all contributed to a paradigm shift in energy systems. This paper presented an agent-based model for simulating wind power systems on multiple time scales. The purpose of the study was to generate a flexible model that would permit simulating the output of a wind farm. The model was developed using multiparadigm modelling. It also combined a variety of approaches such as agent-based modelling, discrete events and dynamic systems. The paper explained the theoretical background concerning the basic models for wind speed generation and power turbines, as well as the fundamentals of agent-based modelling. The implementation of these models was illustrated. The paper also discussed several sample simulations and discussed the application of the model. It was concluded that the paradigm change encompassed new tools and methods that could deal with decentralized decision-making, planning and self-organisation. The large amount of new technologies in the energy production chain requires a shift from a top-down to a more bottom-up approach. 12 refs., 1 tab., 7 figs.

  5. Measurement of oxidatively generated base damage in cellular DNA.

    Science.gov (United States)

    Cadet, Jean; Douki, Thierry; Ravanat, Jean-Luc

    2011-06-03

    This survey focuses on the critical evaluation of the main methods that are currently available for monitoring single and complex oxidatively generated damage to cellular DNA. Among chromatographic methods, HPLC-ESI-MS/MS and to a lesser extent HPLC-ECD which is restricted to a few electroactive nucleobases and nucleosides are appropriate for measuring the formation of single and clustered DNA lesions. Such methods that require optimized protocols for DNA extraction and digestion are sensitive enough for measuring base lesions formed under conditions of severe oxidative stress including exposure to ionizing radiation, UVA light and high intensity UVC laser pulses. In contrast application of GC-MS and HPLC-MS methods that are subject to major drawbacks have been shown to lead to overestimated values of DNA damage. Enzymatic methods that are based on the use of DNA repair glycosylases in order to convert oxidized bases into strand breaks are suitable, even if they are far less specific than HPLC methods, to deal with low levels of single modifications. Several other methods including immunoassays and (32)P-postlabeling methods that are still used suffer from drawbacks and therefore are not recommended. Another difficult topic is the measurement of oxidatively generated clustered DNA lesions that is currently achieved using enzymatic approaches and that would necessitate further investigations.

  6. Measurement of oxidatively generated base damage in cellular DNA

    Energy Technology Data Exchange (ETDEWEB)

    Cadet, Jean, E-mail: jean.cadet@cea.fr [Laboratoire ' Lesions des Acides Nucleiques' , SCIB-UMR-E no3 (CEA/UJF), FRE CNRS 3200, Departement de Recherche Fondamentale sur la Matiere Condensee, CEA/Grenoble, F-38054 Grenoble Cedex 9 (France); Douki, Thierry; Ravanat, Jean-Luc [Laboratoire ' Lesions des Acides Nucleiques' , SCIB-UMR-E no3 (CEA/UJF), FRE CNRS 3200, Departement de Recherche Fondamentale sur la Matiere Condensee, CEA/Grenoble, F-38054 Grenoble Cedex 9 (France)

    2011-06-03

    This survey focuses on the critical evaluation of the main methods that are currently available for monitoring single and complex oxidatively generated damage to cellular DNA. Among chromatographic methods, HPLC-ESI-MS/MS and to a lesser extent HPLC-ECD which is restricted to a few electroactive nucleobases and nucleosides are appropriate for measuring the formation of single and clustered DNA lesions. Such methods that require optimized protocols for DNA extraction and digestion are sensitive enough for measuring base lesions formed under conditions of severe oxidative stress including exposure to ionizing radiation, UVA light and high intensity UVC laser pulses. In contrast application of GC-MS and HPLC-MS methods that are subject to major drawbacks have been shown to lead to overestimated values of DNA damage. Enzymatic methods that are based on the use of DNA repair glycosylases in order to convert oxidized bases into strand breaks are suitable, even if they are far less specific than HPLC methods, to deal with low levels of single modifications. Several other methods including immunoassays and {sup 32}P-postlabeling methods that are still used suffer from drawbacks and therefore are not recommended. Another difficult topic is the measurement of oxidatively generated clustered DNA lesions that is currently achieved using enzymatic approaches and that would necessitate further investigations.

  7. 3D measurement system based on computer-generated gratings

    Science.gov (United States)

    Zhu, Yongjian; Pan, Weiqing; Luo, Yanliang

    2010-08-01

    A new kind of 3D measurement system has been developed to achieve the 3D profile of complex object. The principle of measurement system is based on the triangular measurement of digital fringe projection, and the fringes are fully generated from computer. Thus the computer-generated four fringes form the data source of phase-shifting 3D profilometry. The hardware of system includes the computer, video camera, projector, image grabber, and VGA board with two ports (one port links to the screen, another to the projector). The software of system consists of grating projection module, image grabbing module, phase reconstructing module and 3D display module. A software-based synchronizing method between grating projection and image capture is proposed. As for the nonlinear error of captured fringes, a compensating method is introduced based on the pixel-to-pixel gray correction. At the same time, a least square phase unwrapping is used to solve the problem of phase reconstruction by using the combination of Log Modulation Amplitude and Phase Derivative Variance (LMAPDV) as weight. The system adopts an algorithm from Matlab Tool Box for camera calibration. The 3D measurement system has an accuracy of 0.05mm. The execution time of system is 3~5s for one-time measurement.

  8. An Ethernet LAN based distributed generation system load shedding strategy

    DEFF Research Database (Denmark)

    Wei, Mu; Chen, Zhe

    2011-01-01

    This paper firstly analyzes and compares various communication technologies, and proposes a communication system for a distributed generation system (DGS) with wind turbines. Then the paper presents a novel simulation method of considering the interactions between the communication system and power...... system, by using two software platforms: OPNET and EMTDC/PSCAD. A control method based on the communication technique has been designed to stabilize the DG system during power system disturbances. A case study is presented to demonstrate the effectiveness of the proposed communication system, simulation...... method and control strategy....

  9. Membrane-based processes for sustainable power generation using water

    KAUST Repository

    Logan, Bruce E.

    2012-08-15

    Water has always been crucial to combustion and hydroelectric processes, but it could become the source of power in membrane-based systems that capture energy from natural and waste waters. Two processes are emerging as sustainable methods for capturing energy from sea water: pressure-retarded osmosis and reverse electrodialysis. These processes can also capture energy from waste heat by generating artificial salinity gradients using synthetic solutions, such as thermolytic salts. A further source of energy comes from organic matter in waste waters, which can be harnessed using microbial fuel-cell technology, allowing both wastewater treatment and power production. © 2012 Macmillan Publishers Limited. All rights reserved.

  10. Next-Generation Sequencing-Based Molecular Diagnosis of Choroideremia

    Directory of Open Access Journals (Sweden)

    Kayo Shimizu

    2015-07-01

    Full Text Available We screened patients with choroideremia using next-generation sequencing (NGS and identified a novel mutation and a known mutation in the CHM gene. One patient presented an atypical fundus appearance for choroideremia. Another patient presented macular hole retinal detachment in the left eye. The present case series shows the utility of NGS-based screening in patients with choroideremia. In addition, the presence of macular hole in 1 of the 2 patients, together with a previous report, indicated the susceptibility of patients with choroideremia to macular hole.

  11. Real Time Engineering Analysis Based on a Generative Component Implementation

    DEFF Research Database (Denmark)

    Kirkegaard, Poul Henning; Klitgaard, Jens

    2007-01-01

    The present paper outlines the idea of a conceptual design tool with real time engineering analysis which can be used in the early conceptual design phase. The tool is based on a parametric approach using Generative Components with embedded structural analysis. Each of these components uses...... without jumping from aesthetics to structural digital design tools and back, but to work with both simultaneously and real time. The engineering level of knowledge is incorporated at a conceptual thinking level, i.e. qualitative information is used in stead of using quantitative information. An example...

  12. Pseudo Random Number Generator Based on Back Propagation Neural Network

    Institute of Scientific and Technical Information of China (English)

    WANG Bang-ju; WANG Yu-hua; NIU Li-ping; ZHANG Huan-guo

    2007-01-01

    Random numbers play an increasingly important role in secure wire and wireless communication.Thus the design quality of random number generator(RNG) is significant in information security.A novel pseudo RNG is proposed for improving the security of network communication.The back propagation neural network(BPNN) is nonlinear,which can be used to improve the traditional RNG.The novel pseudo RNG is based on BPNN techniques.The result of test suites standardized by the U.S shows that the RNG can satisfy the security of communication.

  13. Wireless next generation networks a virtue-based trust model

    CERN Document Server

    Harvey, Melissa

    2014-01-01

    This SpringerBrief proposes a trust model motivated by virtue epistemology, addressing the need for a more efficient and flexible trust model for wireless next generation networks. This theory of trust simplifies the computation and communication overhead of strictly cognitive-computational models of trust. Both the advantages and the challenges of virtue-based trust models are discussed. This brief offers new research and a general theory of rationality that enables users to interpret trust and reason as complementary mechanisms that guide our rational conduct at two different epistemic level

  14. Stokes vector formalism based second harmonic generation microscopy

    Science.gov (United States)

    Qiu, Jianjun; Mazumder, Nirmal; Tsai, Han-Ruei; Hu, Chih-Wei; Kao, Fu-Jen

    2012-02-01

    In this study, we have developed a four-channel Stokes vector formalism based second harmonic generation (SHG) microscopy to map and analyze SHG signal. A four-channel Stokesmeter setup is calibrated and integrated into a laser scanning microscope to measure and characterize the SH's corresponding Stokes parameters. We are demonstrating the use of SH and its Stokes parameters to visualize the birefringence and crystalline orientation of KDP and collagen. We believe the developed method can reveal unprecedented information for biomedical and biomaterial studies.

  15. A Random Number Generator Based on Quantum Entangled Photon Pairs

    Institute of Scientific and Technical Information of China (English)

    MA Hai-Qiang; WANG Su-Mei; ZHANG Da; CHANG Jun-Tao; JI Ling-Ling; HOU Yan-Xue; WU Ling-An

    2004-01-01

    A new scheme for a random number generator based on quantum entangled photon pairs is demonstrated.Signal photons produced by optical parametric down-conversion are detected at two single-photon detectors after transmission or reflection at a 50/50% beamsplitter, to form a truly random binary sequence. Their arrival is signalled by their twin idler photons, so that a cw laser source may be used instead of attenuated laser pulses.Coincidence measurement is employed to obtain the bit sequences, which are shown to fully satisfy the standard tests for randomness.

  16. High-Throughput Assessment of Drug Cardiac Safety Using a High-Speed Impedance Detection Technology-Based Heart-on-a-Chip

    Directory of Open Access Journals (Sweden)

    Xi Zhang

    2016-07-01

    Full Text Available Drug cardiac safety assessments play a significant role in drug discovery. Drug-induced cardiotoxicity is one of the main reasons for drug attrition, even when antiarrhythmic drugs can otherwise effectively treat the arrhythmias. Consequently, efficient drug preclinical assessments are needed in the drug industry. However, most drug efficacy assessments are performed based on electrophysiological tests of cardiomyocytes in vitro and cannot effectively provide information on drug-induced dysfunction of cardiomyocyte beating. Here we present a heart-on-a-chip device for evaluating the drug cardiac efficacy using a high-speed impedance detection technology. Verapamil and doxorubicin were utilized to test this heart-on-a-chip, and multiple parameters of cardiomyocyte beating status are used to reveal the effects of drugs. The results show that drug efficacy or cardiotoxicity can be determined by this heart-on-a-chip. We believe this heart-on-a-chip will be a promising tool for the preclinical assessment of drug cardiac efficacy.

  17. Liquid carry-over in an injection moulded all-polymer chip system for immiscible phase magnetic bead-based solid-phase extraction

    Energy Technology Data Exchange (ETDEWEB)

    Kistrup, Kasper, E-mail: kkis@nanotech.dtu.dk [Department of Micro- and Nanotechnology, Technical University of Denmark, DTU Nanotech, Building 345 East, DK-2800 Kongens Lyngby (Denmark); Skotte Sørensen, Karen, E-mail: karen@nanotech.dtu.dk [Department of Micro- and Nanotechnology, Technical University of Denmark, DTU Nanotech, Building 345 East, DK-2800 Kongens Lyngby (Denmark); Center for Integrated Point of Care Technologies (CiPoC), DELTA, Venlighedsvej 4, DK-2870 Hørsholm (Denmark); Wolff, Anders, E-mail: anders.wolff@nanotech.dtu.dk [Department of Micro- and Nanotechnology, Technical University of Denmark, DTU Nanotech, Building 345 East, DK-2800 Kongens Lyngby (Denmark); Fougt Hansen, Mikkel, E-mail: mikkel.hansen@nanotech.dtu.dk [Department of Micro- and Nanotechnology, Technical University of Denmark, DTU Nanotech, Building 345 East, DK-2800 Kongens Lyngby (Denmark)

    2015-04-15

    We present an all-polymer, single-use microfluidic chip system produced by injection moulding and bonded by ultrasonic welding. Both techniques are compatible with low-cost industrial mass-production. The chip is produced for magnetic bead-based solid-phase extraction facilitated by immiscible phase filtration and features passive liquid filling and magnetic bead manipulation using an external magnet. In this work, we determine the system compatibility with various surfactants. Moreover, we quantify the volume of liquid co-transported with magnetic bead clusters from Milli-Q water or a lysis-binding buffer for nucleic acid extraction (0.1 (v/v)% Triton X-100 in 5 M guanidine hydrochloride). A linear relationship was found between the liquid carry-over and mass of magnetic beads used. Interestingly, similar average carry-overs of 1.74(8) nL/µg and 1.72(14) nL/µg were found for Milli-Q water and lysis-binding buffer, respectively. - Highlights: • We present an all-polymer mass producible passive filled microfluidic chip system. • Rapid system fabrication is obtained by injection moulding and ultrasonic welding. • The system is made for single-use nucleic acid extraction using magnetic beads. • We systematically map compatibility of the chip system with various surfactants. • We quantify the volume carry-over of magnetic beads in water and 0.1% triton-X solution.

  18. 基于MSP430的硒鼓芯片复位装置的设计%Design of Cartridge Chip Reset Device Based on MSP430

    Institute of Scientific and Technical Information of China (English)

    高广; 何美玲; 俎全高; 周敏

    2011-01-01

    Aiming at that the printing supplies for laser toner cartridge manufacturer in the production process are needed to resolve the problem of cartridge chip re-use issues, a cartridge chip reset device based on MSP430 is designed. Different types of toner cartridge chips can be reset by the device, so that the cartridge chips can be recycled in order to achieving production cost savings, protecting the environment. The device also has a good reset effect, the advantages of easy operation.%针对激光打印耗材生产厂家硒鼓生产过程中需对硒鼓芯片进行再利用的问题,设计了一种基于MSP430的硒鼓芯片复位装置.利用该装置可以复位不同型号的硒鼓芯片,从而使硒鼓芯片可循环利用,以达到节约生产成本、保护环境的目的.该装置同时具有复位效果好、易于操作的优点.

  19. Sensor-Based Trajectory Generation for Advanced Driver Assistance System

    Directory of Open Access Journals (Sweden)

    Christopher James Shackleton

    2013-03-01

    Full Text Available This paper investigates the trajectory generation problem for an advanced driver assistance system that could sense the driving state of the vehicle, so that a collision free trajectory can be generated safely. Specifically, the problem of trajectory generation is solved for the safety assessment of the driving state and to manipulate the vehicle in order to avoid any possible collisions. The vehicle senses the environment so as to obtain information about other vehicles and static obstacles ahead. Vehicles may share the perception of the environment via an inter-vehicle communication system. The planning algorithm is based on a visibility graph. A lateral repulsive potential is applied to adaptively maintain a trade-off between the trajectory length and vehicle clearance, which is the greatest problem associated with visibility graphs. As opposed to adaptive roadmap approaches, the algorithm exploits the structured nature of the environment for construction of the roadmap. Furthermore, the mostly organized nature of traffic systems is exploited to obtain orientation invariance, which is another limitation of both visibility graphs and adaptive roadmaps. Simulation results show that the algorithm can successfully solve the problem for a variety of commonly found scenarios.

  20. Fuzzy logic based variable speed wind generation system

    Energy Technology Data Exchange (ETDEWEB)

    Simoes, M.G. [Sao Paulo Univ., SP (Brazil). Escola Politecnica. PMC - Mecatronica; Bose, B.K. [Tennessee Univ., Knoxville, TN (United States). Dept. of Electrical Engineering; Spiegel, Ronal J. [Environmental Protection Agency, Research Triangle Park, NC (United States). Air and Energy Engineering Research Lab.

    1996-12-31

    This work demonstrates the successful application of fuzzy logic to enhance the performance and control of a variable speed wind generation system. A maximum power point tracker control is performed with three fuzzy controllers, without wind velocity measurement, and robust to wind vortex and turbine torque ripple. A squirrel cage induction generator feeds the power to a double-sided PWM converter system which pumps the power to a utility grid or supplies to an autonomous system. The fuzzy logic controller FLC-1 searches on-line the generator speed so that the aerodynamic efficiency of the wind turbine is optimized. A second fuzzy controller FLC-2 programs the machine flux by on-line search so as to optimize the machine-converter system wind vortex. Detailed analysis and simulation studies were performed for development of the control strategy and fuzzy algorithms, and a DSP TMS320C30 based hardware with C control software was built for the performance evaluation of a laboratory experimental set-up. The theoretical development was fully validated and the system is ready to be reproduced in a higher power installation. (author) 7 refs., 3 figs., 1 tab.

  1. Repetition rate tunable ultra-short optical pulse generation based on electrical pattern generator

    Institute of Scientific and Technical Information of China (English)

    Xin Fu; Hongming Zhang; Meng Yan; Minyu Yao

    2009-01-01

    @@ An actively mode-locked laser with tunable repetition rate is proposed and experimentally demonstrated based on a programmable electrical pattern generator.By changing the repetition rate of the electrical patterns applied on the in-cavity modulator, the repetition rate of the output optical pulse sequences changes accordingly while the pulse width of the optical pulse train remains almost constant.In other words, the output ultra-short pulse train has a tunable duty cycle.In a proof-of-principle experiment, optical pulses with repetition rates of 10, 5, 2.5 and 1.25 GHz are obtained by adjusting the electrical pattern applied on the in-cavity modulator while their pulse widths remain almost unchanged.

  2. Size-Adjustable Microdroplets Generation Based on Microinjection

    Directory of Open Access Journals (Sweden)

    Shibao Li

    2017-03-01

    Full Text Available Microinjection is a promising tool for microdroplet generation, while the microinjection for microdroplets generation still remains a challenging issue due to the Laplace pressure at the micropipette opening. Here, we apply a simple and robust substrate-contacting microinjection method to microdroplet generation, presenting a size-adjustable microdroplets generation method based on a critical injection (CI model. Firstly, the micropipette is adjusted to a preset injection pressure. Secondly, the micropipette is moved down to contact the substrate, then, the Laplace pressure in the droplet is no longer relevant and the liquid flows out in time. The liquid constantly flows out until the micropipette is lifted, ending the substrate-contacting situation, which results in the recovery of the Laplace pressure at the micropipette opening, and the liquid injection is terminated. We carry out five groups of experiments whereupon 1600 images are captured within each group and the microdroplet radius of each image is detected. Then we determine the relationship among microdroplet radius, radius at the micropipette opening, time, and pressure, and, two more experiments are conducted to verify the relationship. To verify the effectiveness of the substrate-contacting method and the relationship, we conducted two experiments with six desired microdroplet radii are set in each experiment, by adjusting the injection time with a given pressure, and adjusting the injection pressure with a given time. Then, six arrays of microdroplets are obtained in each experiment. The results of the experiments show that the standard errors of the microdroplet radii are less than 2% and the experimental errors fall in the range of ±5%. The average operating speed is 20 microdroplets/min and the minimum radius of the microdroplets is 25 μm. This method has a simple experimental setup that enables easy manipulation and lower cost.

  3. Optical studies of shock generated transient supersonic base flows

    Science.gov (United States)

    Liang, P.-Y.; Bershader, D.; Wray, A.

    1982-01-01

    A shock tube employing interferometric and schlieren techniques is used to study transient base flow phenomena following shock wave passage over two plane bluff bodies: a hemicircular cylinder and a cylinder with the Galileo Jovian probe profile. An attempt is made to understand the physics of transition from transient to steady state flow, and to provide code verification for a study employing the Illiac IV computer. Transient base flow interactions include a series of shock diffraction, regular, and Mach reflections, coupled with boundary layer development, separation, and recompression. Vorticity generation and transport underlie these features. The quantitative verification of the computer code includes comparisons of transient pressure and density fields, near wake geometries, and bow shock standoff distances.

  4. Copula-Based Approach to Synthetic Population Generation

    Science.gov (United States)

    Kim, Deok-Soo

    2016-01-01

    Generating synthetic baseline populations is a fundamental step of agent-based modeling and simulation, which is growing fast in a wide range of socio-economic areas including transportation planning research. Traditionally, in many commercial and non-commercial microsimulation systems, the iterative proportional fitting (IPF) procedure has been used for creating the joint distribution of individuals when combining a reference joint distribution with target marginal distributions. Although IPF is simple, computationally efficient, and rigorously founded, it is unclear whether IPF well preserves the dependence structure of the reference joint table sufficiently when fitting it to target margins. In this paper, a novel method is proposed based on the copula concept in order to provide an alternative approach to the problem that IPF resolves. The dependency characteristic measures were computed and the results from the proposed method and IPF were compared. In most test cases, the proposed method outperformed IPF in preserving the dependence structure of the reference joint distribution. PMID:27490692

  5. Fault Diagnosis Strategies for SOFC-Based Power Generation Plants

    Directory of Open Access Journals (Sweden)

    Paola Costamagna

    2016-08-01

    Full Text Available The success of distributed power generation by plants based on solid oxide fuel cells (SOFCs is hindered by reliability problems that can be mitigated through an effective fault detection and isolation (FDI system. However, the numerous operating conditions under which such plants can operate and the random size of the possible faults make identifying damaged plant components starting from the physical variables measured in the plant very difficult. In this context, we assess two classical FDI strategies (model-based with fault signature matrix and data-driven with statistical classification and the combination of them. For this assessment, a quantitative model of the SOFC-based plant, which is able to simulate regular and faulty conditions, is used. Moreover, a hybrid approach based on the random forest (RF classification method is introduced to address the discrimination of regular and faulty situations due to its practical advantages. Working with a common dataset, the FDI performances obtained using the aforementioned strategies, with different sets of monitored variables, are observed and compared. We conclude that the hybrid FDI strategy, realized by combining a model-based scheme with a statistical classifier, outperforms the other strategies. In addition, the inclusion of two physical variables that should be measured inside the SOFCs can significantly improve the FDI performance, despite the actual difficulty in performing such measurements.

  6. Fault Diagnosis Strategies for SOFC-Based Power Generation Plants.

    Science.gov (United States)

    Costamagna, Paola; De Giorgi, Andrea; Gotelli, Alberto; Magistri, Loredana; Moser, Gabriele; Sciaccaluga, Emanuele; Trucco, Andrea

    2016-08-22

    The success of distributed power generation by plants based on solid oxide fuel cells (SOFCs) is hindered by reliability problems that can be mitigated through an effective fault detection and isolation (FDI) system. However, the numerous operating conditions under which such plants can operate and the random size of the possible faults make identifying damaged plant components starting from the physical variables measured in the plant very difficult. In this context, we assess two classical FDI strategies (model-based with fault signature matrix and data-driven with statistical classification) and the combination of them. For this assessment, a quantitative model of the SOFC-based plant, which is able to simulate regular and faulty conditions, is used. Moreover, a hybrid approach based on the random forest (RF) classification method is introduced to address the discrimination of regular and faulty situations due to its practical advantages. Working with a common dataset, the FDI performances obtained using the aforementioned strategies, with different sets of monitored variables, are observed and compared. We conclude that the hybrid FDI strategy, realized by combining a model-based scheme with a statistical classifier, outperforms the other strategies. In addition, the inclusion of two physical variables that should be measured inside the SOFCs can significantly improve the FDI performance, despite the actual difficulty in performing such measurements.

  7. Bases of motifs for generating repeated patterns with wild cards.

    Science.gov (United States)

    Pisanti, Nadia; Crochemore, Maxime; Grossi, Roberto; Sagot, Marie-France

    2005-01-01

    Motif inference represents one of the most important areas of research in computational biology, and one of its oldest ones. Despite this, the problem remains very much open in the sense that no existing definition is fully satisfying, either in formal terms, or in relation to the biological questions that involve finding such motifs. Two main types of motifs have been considered in the literature: matrices (of letter frequency per position in the motif) and patterns. There is no conclusive evidence in favor of either, and recent work has attempted to integrate the two types into a single model. In this paper, we address the formal issue in relation to motifs as patterns. This is essential to get at a better understanding of motifs in general. In particular, we consider a promising idea that was recently proposed, which attempted to avoid the combinatorial explosion in the number of motifs by means of a generator set for the motifs. Instead of exhibiting a complete list of motifs satisfying some input constraints, what is produced is a basis of such motifs from which all the other ones can be generated. We study the computational cost of determining such a basis of repeated motifs with wild cards in a sequence. We give new upper and lower bounds on such a cost, introducing a notion of basis that is provably contained in (and, thus, smaller) than previously defined ones. Our basis can be computed in less time and space, and is still able to generate the same set of motifs. We also prove that the number of motifs in all bases defined so far grows exponentially with the quorum, that is, with the minimal number of times a motif must appear in a sequence, something unnoticed in previous work. We show that there is no hope to efficiently compute such bases unless the quorum is fixed.

  8. Secure Image Encryption Based On a Chua Chaotic Noise Generator

    Directory of Open Access Journals (Sweden)

    A. S. Andreatos

    2013-10-01

    Full Text Available This paper presents a secure image cryptography telecom system based on a Chua's circuit chaotic noise generator. A chaotic system based on synchronised Master–Slave Chua's circuits has been used as a chaotic true random number generator (CTRNG. Chaotic systems present unpredictable and complex behaviour. This characteristic, together with the dependence on the initial conditions as well as the tolerance of the circuit components, make CTRNGs ideal for cryptography. In the proposed system, the transmitter mixes an input image with chaotic noise produced by a CTRNG. Using thresholding techniques, the chaotic signal is converted to a true random bit sequence. The receiver must be able to reproduce exactly the same chaotic noise in order to subtract it from the received signal. This becomes possible with synchronisation between the two Chua's circuits: through the use of specific techniques, the trajectory of the Slave chaotic system can be bound to that of the Master circuit producing (almost identical behaviour. Additional blocks have been used in order to make the system highly parameterisable and robust against common attacks. The whole system is simulated in Matlab. Simulation results demonstrate satisfactory performance, as well as, robustness against cryptanalysis. The system works with both greyscale and colour jpg images.

  9. Control for Wind Power Generation Based on Inverse System Theory

    Directory of Open Access Journals (Sweden)

    Jiyong Zhang

    2013-11-01

    Full Text Available Traditional Double-fed Wind Generation systems are based on the vector control method, and it is dependent on motor parameters. The performance of the control system will be affected with the parameters changing,. This paper proposes a new control method based on inverse system and variable structure sliding mode(VSS theories, through the inverse system theory, the structure of its state’s equation, obtaining the structure of the inverse system, the establishment of Wind Power Generation closed-loop control system is established. The VSS controller, designed with exponential reaching law, can improve the dynamic performance in normal operation range effectively. When the system operates with variable speed constant frequency (VSCF and the phase voltage drops, the simulations show that the control system can control the DC link voltage steabily, maintain unity power factor, achieve the decoupling of the active and reactive power. And experiments show that the control method used in  VSCF wind power system is feasible.  

  10. Lead Generation and Optimization Based on Protein-Ligand Complementarity

    Directory of Open Access Journals (Sweden)

    Koji Ogata

    2010-06-01

    Full Text Available This work proposes a computational procedure for structure-based lead generation and optimization, which relies on the complementarity of the protein-ligand interactions. This procedure takes as input the known structure of a protein-ligand complex. Retaining the positions of the ligand heavy atoms in the protein binding site it designs structurally similar compounds considering all possible combinations of atomic species (N, C, O, CH3, NH,etc. Compounds are ranked based on a score which incorporates energetic contributions evaluated using molecular mechanics force fields. This procedure was used to design new inhibitor molecules for three serine/threonine protein kinases (p38 MAP kinase, p42 MAP kinase (ERK2, and c-Jun N-terminal kinase 3 (JNK3. For each enzyme, the calculations produce a set of potential inhibitors whose scores are in agreement with IC50 data and Ki values. Furthermore, the native ligands for each protein target, scored within the five top-ranking compounds predicted by our method, one of the top-ranking compounds predicted to inhibit JNK3 was synthesized and his inhibitory activity confirmed against ATP hydrolysis. Our computational procedure is therefore deemed to be a useful tool for generating chemically diverse molecules active against known target proteins.

  11. Ring Counter Based ATPG for Low Transition Test Pattern Generation.

    Science.gov (United States)

    Begam, V M Thoulath; Baulkani, S

    2015-01-01

    In test mode test patterns are applied in random fashion to the circuit under circuit. This increases switching transition between the consecutive test patterns and thereby increases dynamic power dissipation. The proposed ring counter based ATPG reduces vertical switching transitions by inserting test vectors only between the less correlative test patterns. This paper presents the RC-ATPG with an external circuit. The external circuit consists of XOR gates, full adders, and multiplexers. First the total number of transitions between the consecutive test patterns is determined. If it is more, then the external circuit generates and inserts test vectors in between the two test patterns. Test vector insertion increases the correlation between the test patterns and reduces dynamic power dissipation. The results prove that the test patterns generated by the proposed ATPG have fewer transitions than the conventional ATPG. Experimental results based on ISCAS'85 and ISCAS'89 benchmark circuits show 38.5% reduction in the average power and 50% reduction in the peak power attained during testing with a small size decoding logic.

  12. Evaluating the Usability of Optimizing Text-based CAPTCHA Generation

    Directory of Open Access Journals (Sweden)

    Suliman A. Alsuhibany

    2016-08-01

    Full Text Available A CAPTCHA is a test that can, automatically, tell human and computer programs apart. It is a mechanism widely used nowadays for protecting web applications, interfaces, and services from malicious users and automated spammers. Usability and robustness are two fundamental aspects with CAPTCHA, where the usability aspect is the ease with which humans pass its challenges, while the robustness is the strength of its segmentation-resistance mechanism. The collapsing mechanism, which is removing the space between characters to prevent segmentation, has been shown to be reasonably resistant to known attacks. On the other hand, this mechanism drops considerably the human-solvability of text-based CAPTCHAs. Accordingly, an optimizer has previously been proposed that automatically enhances the usability of a CAPTCHA generation without sacrificing its robustness level. However, this optimizer has not yet been evaluated in terms of improving the usability. This paper, therefore, evaluates the usability of this optimizer by conducting an experimental study. The results of this evaluation showed that a statistically significant enhancement is found in the usability of text-based CAPTCHA generation.

  13. Cheek swabs, SNP chips, and CNVs: Assessing the quality of copy number variant calls generated with subject-collected mail-in buccal brush DNA samples on a high-density genotyping microarray

    Directory of Open Access Journals (Sweden)

    Erickson Stephen W

    2012-06-01

    Full Text Available Abstract Background Multiple investigators have established the feasibility of using buccal brush samples to genotype single nucleotide polymorphisms (SNPs with high-density genome-wide microarrays, but there is currently no consensus on the accuracy of copy number variants (CNVs inferred from these data. Regardless of the source of DNA, it is more difficult to detect CNVs than to genotype SNPs using these microarrays, and it therefore remains an open question whether buccal brush samples provide enough high-quality DNA for this purpose. Methods To demonstrate the quality of CNV calls generated from DNA extracted from buccal samples, compared to calls generated from blood samples, we evaluated the concordance of calls from individuals who provided both sample types. The Illumina Human660W-Quad BeadChip was used to determine SNPs and CNVs of 39 Arkansas participants in the National Birth Defects Prevention Study (NBDPS, including 16 mother-infant dyads, who provided both whole blood and buccal brush DNA samples. Results We observed a 99.9% concordance rate of SNP calls in the 39 blood–buccal pairs. From the same dataset, we performed a similar analysis of CNVs. Each of the 78 samples was independently segmented into regions of like copy number using the Optimal Segmentation algorithm of Golden Helix SNP & Variation Suite 7. Across 640,663 loci on 22 autosomal chromosomes, segment-mean log R ratios had an average correlation of 0.899 between blood-buccal pairs of samples from the same individual, while the average correlation between all possible blood-buccal pairs of samples from unrelated individuals was 0.318. An independent analysis using the QuantiSNP algorithm produced average correlations of 0.943 between blood-buccal pairs from the same individual versus 0.332 between samples from unrelated individuals. Segment-mean log R ratios had an average correlation of 0.539 between mother-offspring dyads of buccal samples, which was not

  14. Paper-Based Analytical Biosensor Chip Designed from Graphene-Nanoplatelet-Amphiphilic-diblock-co-Polymer Composite for Cortisol Detection in Human Saliva.

    Science.gov (United States)

    Khan, Muhammad S; Misra, Santosh K; Wang, Zhen; Daza, Enrique; Schwartz-Duval, Aaron S; Kus, Joseph M; Pan, Debanjan; Pan, Dipanjan

    2017-02-07

    Cortisol has been identified as a biomarker in saliva to monitor psychological stress. In this work, we report a label-free paper-based electrical biosensor chip to quantify salivary cortisol at a point-of-care (POC) level. A high specificity of the sensor chip to detect cortisol with a detection limit of 3 pg/mL was achieved by conjugating anticortisol antibody (anti-CAB) on top of gold (Au) microelectrodes using 3,3'-dithiodipropionic acid di(N-hydroxysuccinimide ester (DTSP) as a self-assembled monolayer (SAM) agent. The electrode design utilized poly(styrene)-block-poly(acrylic acid) (PS67-b-PAA27) polymer and graphene nanoplatelets (GP) suspension coated on filter paper to increase the sensitivity of the immune response. A biosensor chip was then integrated with a lab-built low-cost miniaturized printed circuit board (PCB) to provide an electrical connection and to wirelessly transmit/receive electrical signals using MATLAB. This fully integrated proposed hand-held device successfully exhibited a wide cortisol-detection range from 3 pg/mL to 10 μg/mL, with a sensitivity of 50 Ω (pg mL(-1))(-1). The performance of the proposed cortisol sensor chip was validated using an enzyme-linked immunosorbent assay (ELISA) technique with a regression value of 0.9951. The advantages of the newly developed cortisol immune biosensor over previously reported chips include an improved limit of detection, no need for additional redox medium for electron exchange, faster response to achieve stable data, excellent shelf life, and its economical production.

  15. SU-E-T-108: Development of a Novel Clinical Neutron Dose Monitor for Proton Therapy Based On Twin TLD500 Chips in a Small PE Moderator

    Energy Technology Data Exchange (ETDEWEB)

    Hentschel, R; Mukherjee, B [Westdeutsches Protonentherapiezentrum Essen (WPE)gGmbH, Essen (Germany)

    2014-06-01

    Purpose: In proton therapy, it could be desirable to measure out-of-field fast neutron doses at critical locations near and outside the patient body. Methods: The working principle of a novel clinical neutron dose monitor is verified by MCNPX simulation. The device is based on a small PE moderator of just 5.5cm side length for easy handling covered with a thermal neutron suppression layer. In the simulation, a polystyrene phantom is bombarded with a standard proton beam. The secondary thermal neutron flux produced inside the moderator by the impinging fast neutrons from the treatment volume is estimated by pairs of α-Al2O3:C (TLD500) chips which are evaluated offline after the treatment either by TL or OSL methods. The first chip is wrapped with 0.5mm natural Gadolinium foil converting the thermal neutrons to gammas via (n,γ) reaction. The second chip is wrapped with a dummy material. The chip centers have a distance of 2cm from each other. Results: The simulation shows that the difference of gamma doses in the TLD500 chips is correlated to the mean fast neutron dose delivered to the moderator material. Different outer shielding materials have been studied. 0.5mm Cadmium shielding is preferred for cost reasons and convenience. Replacement of PE moderator material by other materials like lead or iron at any place is unfavorable. The spatial orientation of the moderator cube is uncritical. Using variance reduction techniques like splitting/Russian roulette, the TLD500 gamma dose simulation give positive differences up to distances of 0.5m from the treatment volume. Conclusion: Applicability and basic layout of a novel clinical neutron dose monitor are demonstrated. The monitor measures PE neutron doses at locations outside the patient body up to distances of 0.5m from the treatment volume. Tissue neutron doses may be calculated using neutron kerma factors.

  16. Performance Analysis on Router Arbitration for On-chip Networking

    Directory of Open Access Journals (Sweden)

    G. Selvaraj

    2014-08-01

    Full Text Available This study is a comprehensive report on performance analyses of Round Robin and matrix arbitrations to enhance the reliability of on-chip networks. Arbiter is used in Network-on-Chip (NoC router when number of input ports requested is the same as output ports. If many inputs are requested for same output port, the matrix arbiter deals it by forming a 5×5 matrix based on input and output ports. Next, it allots the priority to the requested input ports and simultaneously generates a control signal for selecting the input port to send the packet to output port. The Robin arbiter generates the grant signal on the basis of priority allotted to the input ports. The simulation results of arbitration analysis shows that the router design of front end model consumes less power by 8% and occupies smaller area by 3% on chip. The area on chip is around 64% of available area using Round Robin arbitration compare to that of matrix arbitration. This study also implements hamming distance in order to check the error free data transmission of the NoC router.

  17. Microfluidic chip-based silver nanoparticles aptasensor for colorimetric detection of thrombin.

    Science.gov (United States)

    Zhao, Yaju; Liu, Xiaohui; Li, Jie; Qiang, Weibing; Sun, Liang; Li, Hui; Xu, Danke

    2016-04-01

    In this paper, a colorimetric silver nanoparticles aptasensor (aptamer-AgNPs) was developed for simple and straightforward detection of protein in microfluidic chip. Surface-functionalized microfluidic channels were employed as the capture platform. Then the mixture of target protein and aptamer-AgNPs were injected into the microfluidic channels for colorimetric detection. To demonstrate the performance of this detection platform, thrombin was chosen as a model target protein. Introduction of thrombin could form a sandwich-type complex involving immobilized AgNPs. The amount of aptamer-AgNPs on the complex augmented along with the increase of the thrombin concentration causing different color change that can be analyzed both by naked eyes and a flatbed scanner. This method is featured with low sample consumption, simple processes of microfluidic platform and straightforward colorimetric detection with aptamer-AgNPs. Thrombin at concentrations as low as 20pM can be detected using this aptasensor without signal amplification. This work demonstrated that it had good selectivity over other proteins and it could be a useful strategy to detect other targets with two affinity binding sites for ligands as well.

  18. Chip-integrated plasmonic Schottky photodetection based on hybrid silicon waveguides

    Science.gov (United States)

    Lu, Hua; Gu, Min

    2017-03-01

    We numerically and theoretically investigate the plasmonic Schottky photodetection in a novel hybrid silicon-on-insulator waveguide system, which consists of the silicon waveguides and detection area with the metal stripes and doped silicon film on the silicon dioxide substrate. The results illustrate that the fundamental TE mode in the silicon waveguide can be effectively coupled into the metal/silicon waveguide with the excitation of surface plasmon polaritons (SPPs). The coupling is suppressed for the TM mode due to the mismatch between the electric field distributions of the TM and SPP modes. It is found that the coupling efficiency from the TE to SPP mode is dependent on the width and height of the silicon waveguide and can significantly approach 36.1%. The ultracompact configuration yields a high responsivity of 21.7 mA/W and low dark current of 0.45 μA for the photodetection at the communication wavelength. The plasmonic Schottky photodetector could find favorable applications in the chip-integrated optical interconnects and signal processing.

  19. Energy Efficient On-Chip Communications Implementation Based on Power Slacks

    Institute of Scientific and Technical Information of China (English)

    Xiao-Yu Xia; Wen-Ming Pan; Jia-Chong Kan

    2014-01-01

    ¾The quest for energy efficiency has growing importance in high performance many-core systems. However, in current practices, the power slacks, which are the differences observed between the input power budget and the actual power consumed in the many-core systems, are typically ignored, thus leading to poor energy efficiency. In this paper, we propose a scheme to effectively power the on-chip communications by exploiting the available power slack that is totally wasted in current many-core systems. As so, the demand for extra energy from external power sources (e.g., batteries) is minimized, which helps improve the overall energy efficiency. In essence, the power slack is stored at each node and the proposed routing algorithm uses a dynamic programming network to find the globally optimal path, along which the total energy stored on the nodes is the maximum. Experimental results have confirmed that the proposed scheme, with low hardware overhead, can reduce latency and extra energy consumption by 44% and 48%, respectively, compared with the two competing routing methods.

  20. Generations.

    Science.gov (United States)

    Chambers, David W

    2005-01-01

    Groups naturally promote their strengths and prefer values and rules that give them an identity and an advantage. This shows up as generational tensions across cohorts who share common experiences, including common elders. Dramatic cultural events in America since 1925 can help create an understanding of the differing value structures of the Silents, the Boomers, Gen Xers, and the Millennials. Differences in how these generations see motivation and values, fundamental reality, relations with others, and work are presented, as are some applications of these differences to the dental profession.