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Sample records for chinese traditional medicine

  1. TRADITIONAL CHINESE HERBAL MEDICINE

    NARCIS (Netherlands)

    ZHU, YP; WOERDENBAG, HJ

    1995-01-01

    Herbal medicine, acupuncture and moxibustion, and massage and the three major constituent parts of traditional Chinese medicine. Although acupuncture is well known in many Western countries, Chinese herbal medicine, the mos important part of traditional Chinese medicine, is less well known in the We

  2. Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    2009013 Clinical observation on treatment of active rheumatoid arthritis with Chinese herbal medicine. SHENG Zhenghe(盛正和), et al.Dept TCM, 5th Affili Hosp, Guangxi Med Univ, Guangxi 545001. Chin J Integr Tradit West Med 2008;28(11):990-993. Objective To study the efficacy and safety of Chinese drugs for expelling evil-wind, removing dampness, promoting blood circulation and invigorating yin in treating active rheumatoid arthritis (RA).

  3. TRADITIONAL CHINESE MEDICINE

    Institute of Scientific and Technical Information of China (English)

    1993-01-01

    930433 A study on relationship between hy-pothyroidism and deficiency of kidney YANG.ZHA Lianglun(查良伦),et al.lnstit Integr TCM& West Med,Shanghai Med Univ,Shanghai,200040.Chin J Integr Tradit & West Med 1993;13(4):202—204.Thirty—two cases of hypothyroidism causedby various factors were treated for one year withChinese medicinal herbs preparation“Shen Lutablet”(SLT)to warm and reinforce the KidneyYang.34 normal persons were studied as a con-trol group.After treatment with SLT,the clini-cal symptoms of hypothyroidism were markedlyimproved.Average serum concentration of totalT3,T4 increased significantly from 67.06±4.81

  4. 3.TRADITIONAL CHINESE MEDICINE

    Institute of Scientific and Technical Information of China (English)

    1992-01-01

    920220 Studies on plasma cortisol concen-tration and blood leukocyte content of gluco-corticoid receptors in patients with asthenia-cold asthenia-heat syndrome.ZHANG Guan-gyu (张广宇),XLE Zhufar (谢竹藩).Tradit & West

  5. Traditional Chinese medicine for primary liver cancer

    Institute of Scientific and Technical Information of China (English)

    1998-01-01

    @@ Further progress has been made in the traditional Chinese medicine for primary liver cancer over the past few years, especially in the research of traditional Chinese medicine (TCM) treatment principle, improvement of therapeutic results and prolonging the survival.

  6. Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    2007134 Clinical study on "Jin′s three-needling" in the treatment of generalized anxiety disorder. LUO Wenzheng(罗文政), et al. Coll Acupunct & Massage, Guangzhou TCM Univ, Guangzhou 510405. Chin J Integr Trad & West Med 2007;27(3):201-203. Objective To study the clinical effect of "Jin′s three-needling" in the treatment of generalized anxiety disorder. Methods Fifty-eight patients with generalized anxiety were randomly assigned to two groups equally. the medication group treated with anti-anxiety drugs and the acupuncture group with "Jin′s three-needling". The treatment course was 6 weeks. The clinical effects were evaluated with Hamilton anxiety scale (HAMA), clinical global impression (CGI), and treatment emergent symptom scale (TESS) before treatment and at the end of 2nd, 4th, 6th week of the treatment course. The concentration of 5-hydroxytryptamine (5-HT) in platelet, and plasma levels of corticosterone (CS) and adrenocorticotropic hormone (ACTH) were measured with high performance liquid chromatography-electrochemical detection (HPLC-ED) method before and after treatment. Results The clinical effects in the two groups were equivalent, while the adverse reaction found in the acupuncture group was less than that in the medication group (P<0.05). The platelet concentration of 5-HT and plasma ACTH level decreased significantly in both groups after treatment with insignificant difference between the group (P<0.05). The plasma CS level had no obvious change in the two groups after treatment as compared with that before treatment.Conclusion "Jin′s three-needling" shows similar curative effect on generalized anxiety to routine Western medicine but with less adverse reaction, which may be realized through regulating the platelet 5-HT concentration and plasma ACTH level.

  7. [Traditional Chinese medicine in urology].

    Science.gov (United States)

    Hüsch, T; Tsaur, I; Reiter, M; Mager, R; Haferkamp, A

    2014-11-01

    Traditional Chinese medicine (TCM) is an ancient holistic medicine based on the doctrine of Tao and Qi. Tao represents an alteration from which the polarity of Yin and Yang arises and Qi is the vitality which circulates through the body. Therapeutic concepts of TCM include acupuncture, herbal therapy, nutrition and Tuina, a form of manual therapy. TCM is now gaining increased acceptance in the Western society as a complementary therapy. Acupuncture and herbal therapy are the main forms of implementation of TCM in urology.

  8. Chinese traditional medicine for induction of ovulation

    Institute of Scientific and Technical Information of China (English)

    肖碧莲

    2003-01-01

    This is a review paper of some effective recipes of Chinese traditional medicine usedin ovulation induction and treatment of gynecological diseases. Some clinical results bygynecologists using Chinese traditional medicine in combination with western medicineand results from research on traditional medicine with modern technology are presented.A list of frequently used traditional medicine for ovulation induction are selected from the famous Compendium of Materica Medica(本草纲目)by Li Shi-zhen(李时珍).

  9. [Cataplasma of traditional Chinese medicine].

    Science.gov (United States)

    Jia, Wei; Gao, Wen-yuan; Wang, Tao; Liu, Yun-bin; Xue, Jing; Xiao, Pei-gen

    2003-01-01

    The TCM (traditional Chinese medicine) transdermal plaster (also known as "cataplasma") are flexible adhesive patches used for treatment of pain, resulted from arthritis, sprain and bruise, tendovaginitis, lumbar spine protrude, neuralgia, hyperosteogeny ache, abdominal discomfort and metastatic cancer, etc. Since the 1980's, investigators in China have used this modern patch delivery system for herbal drugs and obtained satisfactory results especially from the treatment of various types of pain associated with bone diseases, abdominal discomfort, and tumors, etc. The production of TCM cataplasma was successfully scaled up in early 90's and the commercial product line for an antirheumatic agent was first established in Shanghai by Leiyunshang Group. Thus far, a number of products in the form of TCM cataplasma became commercially available in the market, and clinical investigations with these products indicated that topically applicable herbal preparations, especially in the form of cataplasma, are preferred formulations with respect to the treatment comfort of the patient. Compared to the traditional preparations which utilize rubber and rosin as adhesives, cataplasma is advantageous in that the lipophilic and hydrophilic ingredients of the herbal extracts are solubilized and then "gellified" with the organic polymers, and that the drug matrix containing up to 40%-70% of water serves as a "drug reservoir" that will sustain the quick and continuous release of herbal ingredients over several days across the skin. While there are conventional remedies for palliation of pain and discomfort associated with bone diseases or cancers, administration of oral medicinal herbs combined with topical agents such as TCM cataplasma may significantly alleviate the symptoms and improve their quality of life. This article provides a review on three aspects, which include the process development, characteristics and developmental status of TCM cataplasma, and future development of

  10. The Relationship between Traditional Chinese Medicine and Modern Medicine

    Directory of Open Access Journals (Sweden)

    Jingcheng Dong

    2013-01-01

    Full Text Available The essence of the traditional Chinese medicine has always been the most advanced and experienced therapeutic approach in the world. It has knowledge that can impact the direction of future modern medical development; still, it is easy to find simple knowledge with mark of times and special cultures. The basic structure of traditional Chinese medicine is composed of three parts: one consistent with modern medicine, one involuntarily beyond modern medicine, and one that needs to be further evaluated. The part that is consistent with modern medicine includes consensus on several theories and concepts of traditional Chinese medicine, and usage of several treatments and prescriptions of traditional Chinese medicine including commonly used Chinese herbs. The part that is involuntarily beyond modern medicine contains several advanced theories and important concepts of traditional Chinese medicine, relatively advanced treatments, formula and modern prescriptions, leading herbs, acupuncture treatment and acupuncture anesthesia of traditional Chinese medicine that affect modern medicine and incorporates massage treatment that has been gradually acknowledged by modern therapy. The part that needs to be further evaluated consists not only the knowledge of pulse diagnosis, prescription, and herbs, but also many other aspects of traditional Chinese medicine.

  11. Artemisinin, a miracle of traditional Chinese medicine.

    Science.gov (United States)

    Kong, Ling Yi; Tan, Ren Xiang

    2015-12-19

    The 2015 Nobel Prize in Physiology or Medicine, shared by Professor Youyou Tu, focused worldwide attention on artemisinin, a natural product antimalarial drug inspired by traditional Chinese medicine (TCM). This is the first Nobel Prize in natural sciences presented to a Chinese scientist for her impactful research work in China in collaboration with other Chinese scientists. We are delighted to provide the background and implications of the discovery of artemisinin, along with our personal viewpoints toward the affordability of modern medicines from natural products.

  12. National semantic infrastructure for traditional Chinese medicine

    Institute of Scientific and Technical Information of China (English)

    Hua-jun CHEN

    2012-01-01

    1 Introduction Traditional Chinese medicine (TCM) is "the traditional medicine that originated in China,and is characterized by holism and treatment based on pattern identification/syndrome differentiation" (WHO,2007).In China,traditional medicine accounts for around 40% of all healthcare delivered;in the West,TCM is increasingly adopted by medical practitioners as a form of complementary and altemative medicine (CAM) (WHO,2002).Both in China and in the West,scientists are attempting to bring the ancient heritage of TCM into line with modem standards,through the scientific development of TCM in the direction of evidence-based medicine (Qiu,2007).There is a pressing need for the digital preservation and global access of TCM knowledge assets.

  13. The Model of Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    薛崇成; 杨秋莉

    2003-01-01

    Medical model, which guides medical practice, belongs to the field of philosophy. It is retrospectivecognition in medicine abroad and changes with the conditions of medical practice. The biologicalmedical model came out in the 15th century. Since then, it has made a great deal of contributions tothe development of medicine. In the late years of the 19th century, biological medical model showedinadequate in some aspects. It was not replaced by biopsychosocial medical model until the 20thcentury. The model of traditional Chinese medicine is prospective. Its formula is Time - Space -Social - Psychological - Biological, which includes more elements than the model of modernmedicine, guiding the practice and development of traditional Chinese medicine for more than twothousand years

  14. [Cultural anthropology of traditional Chinese medicine].

    Science.gov (United States)

    Wan, Xia; Liu, Jian-ping; Ai, Yan-ke; Li, Liu-ji

    2008-07-01

    Biological, psychological and sociological model of medicine substantializes the old model lacking the social humane attributes. The new medical model makes people take medical anthropology into research and highly evaluate traditional medical system. Cultural anthropology of traditional Chinese medicine (TCM) is part of medical anthropology with three major characteristics: wide research scope, specificity, and integration. It has developed its own research methods, such as field investigation, comprehensive inspection and comparison study. Cultural anthropology provides an efficient research method for TCM, and its application would further develop TCM theory and form comprehensive evaluation on TCM effects.

  15. Role of Traditional Chinese Medicine in Integrative Medicine

    Institute of Scientific and Technical Information of China (English)

    吕爱平; 吕维柏; 吕青平

    2004-01-01

    @@ Complementary & alternative medicine (CAM) is getting more and more important in improving human health. Traditional Chinese medicine (TCM), with her thousands of years history and contributions to the health of Chinese people, definitely is vital in CAM in China. Medical sciences including CAM and mainstream medicine, with unified specific aim, could be integrated and become integrative medicine. During the integration, TCM would contribute much more in the progress with her cultural background and clinical efficacy. This paper will discuss how TCM takes part in the inte gration via her function in clinical practice.

  16. Comparison of Sasang Constitutional Medicine, Traditional Chinese Medicine and Ayurveda

    Directory of Open Access Journals (Sweden)

    Jong Yeol Kim

    2011-01-01

    Full Text Available Sasang constitutional medicine (SCM, traditional Chinese medicine (TCM and Ayurveda are three different forms of Asian traditional medicine. Although these traditions share a lot in common as holistic medicines, the different philosophical foundations found in each confer distinguishing attributes and unique qualities. SCM is based on a constitution-based approach, and is in this way relatively more similar to the Ayurvedic tradition than to the TCM, although many of the basic SCM theories were originally derived from TCM, a syndrome-based medicine. SCM and TCM use the same botanical materials that are distributed mainly in the East Asian region, but the basic principles of usage and the underlying rationale are completely different from each other. Meanwhile, the principles of the Ayurvedic use of botanical resources are very similar to those seen in SCM, but the medicinal herbs used in Ayurveda generally originate from the West Asian region which displays a different spectrum of flora.

  17. Traditional Chinese medicine education in Canada.

    Science.gov (United States)

    Du, Huan-bin

    2015-03-01

    The history of education and legislation of traditional Chinese medicine (TCM) and acupuncture in Canada is short. The first school of TCM opened its door to the general public in Canada in 1985 and the first legislation of acupuncture was introduced in Alberta, Canada in 1988. Currently, TCM and/or acupuncture have been regulated in five provinces in Canada. The legislation and regulation, as well as education of TCM and acupuncture vary among the five provinces in Canada. Opportunities and challenges facing TCM education exist simultaneously. Strategies are proposed to develop an international standard for TCM education in Canada, and possibly in other English speaking countries as well.

  18. Chemometrics and modernization of traditional Chinese medicine

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Development of chromatographic fingerprinting and its related chemometric methods in the research of quality control of traditional Chinese medicines(TCMs) are discussed. The quality control methods for guarantying the authentication and stability of products and semi-products of TCMs are firstly assessed. The technique based on chromatographic fingerprinting is essentially a kind of high-through put and integral tools to explore the complexity of herbal medicines. In order to further control the comprehensive quality of TCMs,confirmation and identification of their important chemical components are necessary. Some new strategies are proposed to trace the chemical changes of chromatographic fingerprints both in product processing and/or after their administration by modern chromatographic techniques and chemometrics. Combined with systems biology and bioinformatics,it seems possible for one to reveal the working mechanism of TCMs and to further control their intrinsic quality comprehensively.

  19. Protecting traditional knowledge of Chinese medicine: concepts and proposals.

    Science.gov (United States)

    Liu, Changhua; Gu, Man

    2011-06-01

    With the development of the knowledge economy, knowledge has become one of the most important resources for social progress and economic development. Some countries have proposed measures for the protection of their own traditional knowledge. Traditional Chinese medicine belongs to the category of intangible cultural heritage because it is an important part of Chinese cultural heritage. Today the value of traditional knowledge of Chinese medicine has been widely recognized by the domestic and international public. This paper discusses the definition of traditional knowledge of Chinese medicine and its protection, and evaluates research on its classification. We review the present status of the protection of traditional knowledge of Chinese medicine and tentatively put forward some possible ideas and methods for the protection of traditional knowledge of Chinese medicine. Our goal is to find a way to strengthen the vitality of traditional Chinese medicine and consolidate its foundation. We believe that if we could establish a suitable sui generis(sui generis is a Latin term meaning "of its own kind" and is often used in discussions about protecting the rights of indigenous peoples. Here we use it to emphasize the fact that protection of traditional knowledge of Chinese medicine cannot be achieved through existing legal means of protection alone due to its unique characteristics) system for traditional knowledge, a more favorable environment for the preservation and development of traditional Chinese medicine will ultimately be created.

  20. Theory of traditional Chinese medicine and therapeutic method of diseases.

    Science.gov (United States)

    Lu, Ai-Ping; Jia, Hong-Wei; Xiao, Cheng; Lu, Qing-Ping

    2004-07-01

    Traditional Chinese medicine, including herbal medicine and acupuncture, as one of the most important parts in complementary and alternative medicine (CAM), plays the key role in the formation of integrative medicine. Why do not the modern drugs targeting the specificity of diseases produce theoretical effects in clinical observation? Why does not the traditional Chinese medicine targeting the Zheng (syndrome) produce theoretical effects in clinic? There should have some reasons to combine Western medicine with Chinese herbal medicine so as to form the integrative medicine. During the integration, how to clarify the impact of CAM theory on Western medicine has become an emergent topic. This paper focuses on the exploration of the impact of theory of traditional Chinese medicine on the therapy of diseases in Western medicine.

  1. Theory of traditional Chinese medicine and therapeutic method of diseases

    Institute of Scientific and Technical Information of China (English)

    Ai-Ping Lu; Hong-Wei Jia; Cheng Xiao; Qing-Ping Lu

    2004-01-01

    Traditional Chinese medicine, including herbal medicine and acupuncture, as one of the most important parts in complementary and alternative medicine (CAM), plays the key role in the formation of integrative medicine. Why do not the modern drugs targeting the specificity of diseases produce theoretical effects in clinical observation? Why does not the traditional Chinese medicine targeting the Zheng (syndrome) produce theoretical effects in clinic?There should have some reasons to combine Western medicine with Chinese herbal medicine so as to form the integrative medicine. During the integration, how to clarify the impact of CAM theory on Western medicine has become an emergent topic. This paper focuses on the exploration of the impact of theory of traditional Chinese medicine on the therapy of diseases in Western medicine.

  2. Cardiovascular Disease, Mitochondria, and Traditional Chinese Medicine

    Directory of Open Access Journals (Sweden)

    Jie Wang

    2015-01-01

    Full Text Available Recent studies demonstrated that mitochondria play an important role in the cardiovascular system and mutations of mitochondrial DNA affect coronary artery disease, resulting in hypertension, atherosclerosis, and cardiomyopathy. Traditional Chinese medicine (TCM has been used for thousands of years to treat cardiovascular disease, but it is not yet clear how TCM affects mitochondrial function. By reviewing the interactions between the cardiovascular system, mitochondrial DNA, and TCM, we show that cardiovascular disease is negatively affected by mutations in mitochondrial DNA and that TCM can be used to treat cardiovascular disease by regulating the structure and function of mitochondria via increases in mitochondrial electron transport and oxidative phosphorylation, modulation of mitochondrial-mediated apoptosis, and decreases in mitochondrial ROS. However further research is still required to identify the mechanism by which TCM affects CVD and modifies mitochondrial DNA.

  3. Theory of traditional Chinese medicine and therapeutic method of diseases

    OpenAIRE

    Lu, Ai-Ping; Jia, Hong-Wei; Xiao, Cheng; Lu, Qing-Ping

    2004-01-01

    Traditional Chinese medicine, including herbal medicine and acupuncture, as one of the most important parts in complementary and alternative medicine (CAM), plays the key role in the formation of integrative medicine. Why do not the modern drugs targeting the specificity of diseases produce theoretical effects in clinical observation? Why does not the traditional Chinese medicine targeting the Zheng (syndrome) produce theoretical effects in clinic? There should have some reasons to combine We...

  4. Traditional Chinese Medicine for Senile Dementia

    Directory of Open Access Journals (Sweden)

    Zhihong Lin

    2012-01-01

    Full Text Available Traditional Chinese Medicine (TCM has a 3000 years' history of human use. A literature survey addressing traditional evidence from human studies was done, with key result that top 10 TCM herb ingredients including Poria cocos, Radix polygalae, Radix glycyrrhizae, Radix angelica sinensis, and Radix rehmanniae were prioritized for highest potential benefit to dementia intervention, related to the highest frequency of use in 236 formulae collected from 29 ancient Pharmacopoeias, ancient formula books, or historical archives on ancient renowned TCM doctors, over the past 10 centuries. Based on the history of use, there was strong clinical support that Radix polygalae is memory improving. Pharmacological investigation also indicated that all the five ingredients mentioned above can elicit memory-improving effects in vivo and in vitro via multiple mechanisms of action, covering estrogen-like, cholinergic, antioxidant, anti-inflammatory, antiapoptotic, neurogenetic, and anti-Aβ activities. Furthermore, 11 active principles were identified, including sinapic acid, tenuifolin, isoliquiritigenin, liquiritigenin, glabridin, ferulic acid, Z-ligustilide, N-methyl-beta-carboline-3-carboxamide, coniferyl ferulate and 11-angeloylsenkyunolide F, and catalpol. It can be concluded that TCM has a potential for complementary and alternative role in treating senile dementia. The scientific evidence is being continuously mined to back up the traditional medical wisdom.

  5. On the Natural Medical Features of Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    Zhu Ming; Gong Jiapei; Liu Yuanlong

    2007-01-01

    @@ Heaven-human-earth Pattern (HHE) regarded as a crucial conception of traditional Chinese medicine (TCM) has been applied extensively in TCM diagnostics, etiology, acupuncture therapeutics, materia medica and herbal formula, etc. It associates closely with Chinese classic cosmology.

  6. [Problems in medicinal materials research of new traditional Chinese medicine].

    Science.gov (United States)

    Zhou, Gang; Wang, Ting; He, Yan-Ping

    2014-08-01

    Medicinal materials research and development of new drug of traditional Chinese medicine (TCM) research is the premise and foundation of new drug research and development, it throughout the whole process of new drug research. Medicinal materials research is one of the main content of the pharmaceutical research of new drug of TCM, and it is also the focus of the new medicine pharmaceutical evaluation content. This article through the analysis of the present problems existing in the development of TCM research of new drug of TCM, from medicine research concept, quality stability, quality standard, etc are expounded, including medicine research idea value medicine study should focus on the important role and from the purpose for the top-level design of new drug research problem. Medicinal materials quality stability should pay attention to the original, medicinal part, origin, processing, storage, planting (breeding), and other aspects. Aspect of quality standard of medicinal materials should pay attention to establish the quality standards of conform to the characteristics of new drug of TCM. As the instruction of TCM new drug research and development and the scientific nature of the review, and provide the basis for medicinal material standards.

  7. Pharmacokinetics Applications of Traditional Chinese Medicines

    Institute of Scientific and Technical Information of China (English)

    Qiu-Ju Li; Ai-Hua Zhang; Hui Sun; Xi-Jun Wang

    2016-01-01

    Traditional Chinese medicine (TCM) has been widely used in many oriental countries for thousands of years and played an indispensable role in the prevention and treatment of diseases, especially the complicated and chronic ones. It is a very complex mixture containing hundreds or thousands of different components. Pharmacokinetic study on active constituents in TCM preparations is a good way for us to explain and predict a variety of events related to the efficacy and toxicity of TCM. In the drug discovery phases, pharmacokinetics is a key to guide medicinal chemists in the optimization process of a chemical series and to assist pharmacologists to design in vivo studies. To explore the potentially bioactive components in TCM, it is necessary to further study the in vivo pharmacokinetic characteristics of multiple absorbed components and find out the optical time-course behavior to providing more substantial research for new leads in drug discovery. Pharmacokinetics screening method could provide a reliable means of prospecting natural products in the search for new leads in drug discovery. This review summarizes the research progress of PK on TCM in the search for suitable lead compounds in recent years.

  8. Traditional Chinese Medicine for Chronic Fatigue Syndrome

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    Rui Chen

    2010-01-01

    Full Text Available More and more patients have been diagnosed as having chronic fatigue syndrome (CFS in recent years. Western drug use for this syndrome is often associated with many side-effects and little clinical benefit. As an alternative medicine, traditional Chinese medicine (TCM has provided some evidences based upon ancient texts and recent studies, not only to offer clinical benefit but also offer insights into their mechanisms of action. It has perceived advantages such as being natural, effective and safe to ameliorate symptoms of CFS such as fatigue, disordered sleep, cognitive handicaps and other complex complaints, although there are some limitations regarding the diagnostic standards and methodology in related clinical or experimental studies. Modern mechanisms of TCM on CFS mainly focus on adjusting immune dysfunction, regulating abnormal activity in the hypothalamic-pituitary-adrenal (HPA axis and serving as an antioxidant. It is vitally important for the further development to establish standards for ‘zheng’ of CFS, i.e. the different types of CFS pathogenesis in TCM, to perform randomized and controlled trials of TCM on CFS and to make full use of the latest biological, biochemical, molecular and immunological approaches in the experimental design.

  9. Sasang Constitutional Medicine and Traditional Chinese Medicine: A Comparative Overview

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    Junghee Yoo

    2012-01-01

    Full Text Available Sasang constitutional medicine (SCM is a holistic typological constitution medicine which balances psychological, social, and physical aspects of an individual to achieve wellness and increase longevity. SCM has the qualities of preventative medicine, as it emphasizes daily health management based on constitutionally differentiated regimens and self-cultivation of the mind and body. This review's goal is to establish a fundamental understanding of SCM and to provide a foundation for further study. It compares the similarities and differences of philosophical origins, perspectives on the mind (heart, typological systems, pathology, and therapeutics between SCM and traditional Chinese medicine (TCM. TCM is based on the Taoist view of the universe and humanity. The health and longevity of an individual depends on a harmonious relationship with the universe. On the other hand, SCM is based on the Confucian view of the universe and humanity. SCM focuses on the influence of human affairs on the psyche, physiology, and pathology.

  10. Cellular traditional Chinese medicine on photobiomodulation

    Science.gov (United States)

    Liu, Timon Cheng-Yi; Cheng, Lei; Liu, Jiang; Wang, Shuang-Xi; Xu, Xiao-Yang; Deng, Xiao-Yuan; Liu, Song-Hao

    2006-09-01

    Although yin-yang is one of the basic models of traditional Chinese medicine (TCM) for TCM objects such as whole body, five zangs or six fus, they are widely used to discuss cellular processes in papers of famous journals such as Cell, Nature, or Science. In this paper, the concept of the degree of difficulty (DD) of a process was introduced to redefine yin and yang and extend the TCM yin-yang model to the DD yin-yang model so that we have the DD yin-yang inter-transformation, the DD yin-yang antagonism, the DD yin-yang interdependence and the DD yin ping yang mi, which and photobiomodulation (PBM) on cells are supported by each other. It was shown that healthy cells are in the DD yin ping yang mi so that there is no PBM, and there is PBM on non-healthy cells until the cells become healthy so that PBM can be called a cellular rehabilitation. The DD yin-yang inter-transformation holds for our biological information model of PBM. The DD yin-yang antagonism and the DD yin-yang interdependence also hold for a series of experimental studies such as the stimulation of DNA synthesis in HeLa cells after simultaneous irradiation with narrow-band red light and a wide-band cold light, or consecutive irradiation with blue and red light.

  11. [Analysis on complex characteristics of traditional Chinese medicine property theory].

    Science.gov (United States)

    Jin, Rui; Zhang, Bing

    2012-11-01

    The traditional Chinese medicine property theory refers to a concept for medicines and their effects under the guidance of traditional Chinese medicine theories. The traditional Chinese medicine property theory studies the formation mechanism and the application regularity of traditional Chinese medicine properties, including four Qi, five flavors, meridian entry, direction of medicinal actions (upward, downward, outward and inward) and toxicity. Embryologically, the traditional Chinese medicine property theory is closely related to medicines and their effects and heavily influenced by philosophical thoughts such as yin-yang and five elements and comparative state, thereby showing complex characteristics. This mainly reflects in that: first, medical properties are formed from multiple sources, with non-unique determination approach in early stage and non-unique corresponding effects and actions; second, medical properties are expressed in multiple characteristics, with diverse representation indicators and factors influencing actual expressions. The modern studies on the traditional Chinese medicine property theory shall focus on these complex characteristics, give attention to the dialectical unity of medical properties and effects and look for individuality as well as generality.

  12. Applications of traditional Chinese medicines: bacterial biofilms as a target

    NARCIS (Netherlands)

    Wu, X.

    2015-01-01

    Chinese Herbal Medicines (CHM) are of significant importance for human health care in China and have a profound cultural and philosophical background described in the Traditional Chinese Medicine (TCM) theories. The main objective of TCM is to maintain or restore the balance of the body as a whole (

  13. Ayurveda and Traditional Chinese Medicine: A Comparative Overview

    Directory of Open Access Journals (Sweden)

    Bhushan Patwardhan

    2005-01-01

    Full Text Available Ayurveda, the traditional Indian medicine (TIM and traditional Chinese medicine (TCM remain the most ancient yet living traditions. There has been increased global interest in traditional medicine. Efforts to monitor and regulate herbal drugs and traditional medicine are underway. China has been successful in promoting its therapies with more research and science-based approach, while Ayurveda still needs more extensive scientific research and evidence base. This review gives an overview of basic principles and commonalities of TIM and TCM and discusses key determinants of success, which these great traditions need to address to compete in global markets.

  14. Traditional Chinese and Thai medicine in a comparative perspective.

    Science.gov (United States)

    He, Ke

    2015-12-01

    The work presented in this paper compares traditional Chinese medicine and traditional Thai medicine, expounding on origins, academic thinking, theoretical system, diagnostic method and modern development. Based on a secondary analysis of available literature, the paper concentrates on two crucial historical developments: (1) the response to, and consequences of, the impact of the Western medicine; and (2) the revival of traditional medicine in these two countries and its prospects. From a comparative perspective, the analysis has led to the conclusion that the rise and fall of traditional medicine is an issue closely related with social and political issues; and the development of traditional medicines requires national policy and financial support from governments, human resource development, the improvement of service quality, and the dissemination of traditional medicine knowledge to the public. In addition, this paper also suggests deepening exchanges and cooperation between China and Thailand, strengthening cooperation between traditional medicine and medical tourism.

  15. [Theory and practice of bionic cultivation of traditional Chinese medicine].

    Science.gov (United States)

    Liu, Dahui; Huang, Luqi; Guo, Lanping; Shao, Aijuan; Chen, Meilan

    2009-03-01

    The bionic cultivation of medicinal plant is an ecological cultivation pattern, which is adopting ecological engineering and modern agricultural techniques to simulate the natural ecosystem of wild medicinal plant community, and has been given greater attention on the agriculture of traditional Chinese medicine (TCM). It is also the cross subject that combines Chinese traditional medicine, agronomy, horticulture, ecology, agricultural engineering and management. Moreover, it has significant technology advantages of promoting the sustainable utilization of medicinal plant resources, improving the ecological environment and harmonizing man and nature. So it's important to develop the bionic cultivation of TCM.

  16. Integration of Traditional Chinese Medicine and modern medicine promotes the unification of human medicine

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    Peng Zhang

    2010-10-01

    Full Text Available "nThere are two mutually supportive systems in medical profession: modern medicines and traditional medicine. The current status is that although the modern medicine occupies the major position in healthcare system, the therapeutic effect of traditional medicines should not be omitted. If all of them merged and unified as one, it will be beneficial to the development of human medicine. In this paper, the integration of Traditional Chinese Medicine (TCM and modern medicine was exemplified to elucidate the mutual complements, mutual benefits of traditional medicines and modern medicine to maintain the unification of human medicine via the development of molecular biology, cytology etc. We believed that TCM theory may share the same mechanism with western medicine at some extent which need to be explored in the future research. In our point of view, although the road may twist and turn, the results are promising.

  17. Traditional Chinese Medicine in the Prevention of Disease

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    Claudia Patricia Ardila Jaimes

    2015-05-01

    Full Text Available Introduction: Traditional Chinese medicine is based on the oriental philosophy developed thousands of years ago, their understanding involves a deep understanding and knowledge of it. Materials and methods: This article seeks to reflect on the philosophy behind Chinese medicine and the role it has played in preventing the disease. Results: Three perspectives related to the philosophical foundations of traditional Chinese medicine and prevention analysis, the rise and popularity of its use in the prevention and the role of science in strengthening the evidence in the therapeutic of Traditional Chinese Medicine addresses. Conclusion: The contribution of TCM to the prevention of diseases can be magnified to the extent that their study will expand and further substantiate its effectiveness.

  18. Traditional Chinese medicine and oral diseases: today and tomorrow.

    Science.gov (United States)

    Zheng, L W; Hua, H; Cheung, L K

    2011-01-01

    With a history of over 2000 years, traditional Chinese medicine (TCM) evolves into a unique system of diagnosing and treating illnesses. It is a challenge to convey the fundamentals of this traditional medicine to our Western colleagues because of the differences in language, philosophy and concept of diagnosis and treatment. This review attempts to tackle these barriers by introducing several widely used Chinese medicines for treating oral diseases. China Journals Full-text Database and Pubmed were used as the searching engines. Although many studies have demonstrated that the Chinese medicines are effective in treating oral diseases including recurrent aphthous stomatitis, oral lichen planus, leukoplakia, and Sjögren's syndrome, most of them lacked standard criteria of post-treatment assessment and laboratory evidence. Randomized controlled clinical trials with specific assessment criteria are required to close the gap between TCM and evidenced-based medicine.

  19. [Study on dosage form design for improving oral bioavailability of traditional Chinese medicines].

    Science.gov (United States)

    Xia, Hai-Jian; Zhang, Zhen-Hai; Yao, Dong-Dong; Jia, Xiao-Bin

    2013-09-01

    Both chemical drugs and traditional Chinese medicines have the problem of low bioavailability. However, as traditional Chinese medicines are a multi-component complex, their dosage forms are required to be designed in line with their characteristics, in order to improve the bioavailability of traditional Chinese medicines. Traditional Chinese medicines are mostly prepared into pill, powder, paste, elixir and decoction, but with such drawbacks as high administration dose and poor efficacy. With the process of modernization of traditional Chinese medicines, new-type preparations have be developed and made outstanding achievements. However, they fail to make an organic integration between traditional Chinese medicine theories and modern preparation theories. Characteristics of traditional Chinese medicines are required to be taken into account during the development of traditional Chinese medicines. In the article, multi-component preparation technology was adopted to establish a multi-component drug release system of traditional Chinese medicines on the basis of multiple components of traditional Chinese medicines.

  20. Globalization of Traditional Chinese Medicinal products And New Regulatory Structures in the European Union

    Institute of Scientific and Technical Information of China (English)

    Emiel Van Galen; Burt Kroes

    2009-01-01

    @@ Traditional Chinese Medicine (TCM) , Registration, EU pharmaceutical legislation, Traditional Herbal Medicinal Products, tHMP, quality, safety, efficacy, traditional use, EMEA, European Medicines Agency, European Pharmacopoeia, Herbal Medicinal Products Committee, HMPC, Community Monographs, Commu-nity List.

  1. Management of Hepatic Encephalopathy by Traditional Chinese Medicine

    Directory of Open Access Journals (Sweden)

    Chun Yao

    2012-01-01

    Full Text Available In spite of the impressive progress in the investigation of hepatic encephalopathy (HE, the complex mechanisms underlying the onset and deterioration of HE are still not fully understood. Currently, none of the existing theories provide conclusive explanations on the symptoms that link liver dysfunction to nervous system disorders and clinical manifestations. This paper summarized the diagnostic and therapeutic approaches used for HE in modern medicine and traditional Chinese medicine and provided future perspective in HE therapies from the viewpoint of holistic and personalized Chinese medicine.

  2. The Concept of Wind in Traditional Chinese Medicine

    Directory of Open Access Journals (Sweden)

    Mehrab Dashtdar

    2016-12-01

    Full Text Available The use of folk medicine has been widely embraced in many developed countries under the name of traditional, complementary and alternative medicine (TCAM and is now becoming the mainstream in the UK and the rest of Europe, as well as in North America and Australia. Diversity, easy accessibility, broad continuity, relatively low cost, base levels of technological inputs, fewer side effects, and growing economic importance are some of the positive features of folk medicine. In this framework, a critical need exists to introduce the practice of folk medicine into public healthcare if the goal of reformed access to healthcare facilities is to be achieved. The amount of information available to public health practitioners about traditional medicine concepts and the utilization of that information are inadequate and pose many problems for the delivery of primary healthcare globally. Different societies have evolved various forms of indigenous perceptions that are captured under the broad concept of folk medicine, e.g., Persian, Chinese, Grecian, and African folk medicines, which explain the lack of universally accepted definitions of terms. Thus, the exchange of information on the diverse forms of folk medicine needs to be facilitated. Various concepts of Wind are found in books on traditional medicine, and many of those go beyond the boundaries established in old manuscripts and are not easily understood. This study intends to provide information, context, and guidance for the collection of all important information on the different concepts of Wind and for their simplification. This new vision for understanding earlier Chinese medicine will benefit public health specialists, traditional and complementary medicine practitioners, and those who are interested in historical medicine by providing a theoretical basis for the traditional medicines and the acupuncture that is used to eliminate Wind in order to treat various diseases.

  3. Traditional Chinese medicine in treatment of opiate addiction

    Institute of Scientific and Technical Information of China (English)

    Jie SHI; Yan-li LIU; Yu-xia FANG; Guo-zhu XU; Hai-fen ZHAI; Lin LU

    2006-01-01

    Traditional Chinese medicine (TCM) includes Chinese medicine and acupuncture. Chinese medicine consists of natural products including plants, animals and minerals. TCM has been practiced in China for more than 2000 years, and for the past 200 years has been used in treatment of drug addiction. Ten Chinese medicines for the treatment of opiate addiction have been approved by the Chinese State Food and Drug Administration (SFDA), and at least 6 are in clinical trials. The general therapeutic principle of Chinese medicine developed was based on its unique theory of "reinforcing healthy Qi and resolving and removing effects of toxicity". Acupuncture, another essential part of TCM, which was developed based on the principle that "functions of the human body are controlled by the 'Jing-Luo' and 'Qi-Xue' system", has been used not only in China, but also in Europe, the USA and other countries, for controlling opiate addiction. There are some advantages in using TCM for opiate detoxification, including less harmful side effects, high safety and ideal effects in the inhibition of protracted withdrawal symptoms and relapse. Co-administration of TCM with modern medicine shows some synergistic effects in detoxification. Many TCM for detoxification also have efficacy in the rehabilitation of abnormal body functions induced by chronic drug use, including improving immune function, increasing working memory and preventing neurological disorder. Given that TCM is effective in the prevention of relapse and causes fewer side effects, it may be used widely in the treatment of opiate addiction.

  4. Health-seeking behaviours and use of traditional Chinese medicine among the British Chinese

    OpenAIRE

    Rochelle, T.L.

    2005-01-01

    This dissertation for the Degree of Doctor of Psychology (Health) presents three pieces of work: 1) Systematic Review of Acupuncture as an Intervention for the Alleviation of Chronic Back Pain. 2) Health-Seeking Behaviours and Use of Traditional Chinese Medicine among the British Chinese 3) Design of an evaluation to measure outcomes of a Traditional Chinese Medicine Clinic for a Chinese Health Centre in London's Chinatown. The underlying theme linking these three pieces of work is Traditiona...

  5. Effects of Traditional Chinese Medicine on Congestive Heart Failure

    Institute of Scientific and Technical Information of China (English)

    任海玲; 李海芸; 江时森

    2002-01-01

    Congestive heart failure (CHF) belongs to the category of "palpitation", "chest pain", "retention of phlegm and fluid" etc. in traditional Chinese medicine (TCM). The medical books of past generations recorded a lot of important prescriptions to treat above-mentioned symptoms. This article briefly summarized certain TCM prescriptions on pharmacological actions and therapeutic effects of CHF.

  6. Pharmacology and modernization of traditional Chinese medicine

    Institute of Scientific and Technical Information of China (English)

    PeterK.T.PANG; G.Z.LIU; C.F.CHEN; J.X.YANG; J.P.SO

    2004-01-01

    Traditional TCM does not need modernization. What needs modernization are the commercial TCM products which have become the prevailing form of TCM. Traditional TCM treats patients individually and different practitioners prescribe their individual formulations. There is no way to modernize such a fine-tuned traditional approach. Commercial TCM is a marketable product for the treatment of the mass population. These are two different forms of medical practice. This form of TCM has

  7. GAP - A Milestone in Traditional Chinese Medicine Production

    Institute of Scientific and Technical Information of China (English)

    MENGJIE; YUJIE

    2004-01-01

    IT is clear that in order for TCM (Traditional Chinese Medicine) production to meet world standards and enter the international market, herb plantation in China must be standardized. In late September 2003, the US FDA(Food and Drug Administration)held a seminar on the standardization of TCM development and quality control. It reached the conclusion that as long as the Chinese medicine production process meets GAP (Good Agricultural Practice,meaning standardized herbal material plantation), GLP (Good Laboratory Practice, meaning standardized experimental research)and GMP (Good Manufacturing Practice, meaning standardized extraction and preparation technology) standards, TCM products merit certification.

  8. Progress of Research on Organic Fibrosis with Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    Qing-Lan Wang; Xiao-Ning Wang; Ping Liu

    2016-01-01

    Fibrosis is the remodeling and repair processes of chronic injuries. There are few effective therapies. Chinese medicine formula, the main pattern of traditional Chinese medicine (TCM) in clinic, applies a multi-component, multi-target and complicated approach in the treatment of diseases, and certainly shows good comprehensive therapeutic effects on fibrosis. In this review, the clinical study, effects and mechanism of action of Fuzheng Huayu recipe in the treatment of liver, pulmonary, and renal fibrosis was analyzed and evaluated. Meanwhile, based on the understanding of TCM pathogenesis for liver cirrhosis, this review will also briefly introduce the research of different classical Chinese medicine formulae with various functions in the treatment of experimental liver fibrosis induced by different methods, including comparing the efficacy, analyzing the action characteristics and mechanism of effective formulae, exploring pathological and biological basis of TCM diagnostic and therapeutic pattern, which will contribute to the research of TCM in the treatment of organ fibrosis.

  9. Regulating Traditional Chinese Medicine Practitioners and Acupuncturists in Ontario, Canada

    Directory of Open Access Journals (Sweden)

    Glen E. Randall

    2015-12-01

    Full Text Available In 2006, the Ontario government passed the Traditional Chinese Medicine Act, which granted Traditional Chinese Medicine practitioners and Acupuncturists (TCM/A practitioners self-regulatory status under the Regulated Health Professions Act, 1991. The goal of the legislation was to create a new regulatory college that would set and enforce high standards of care and safety in order to enhance public protection and access to a range of traditional and alternative therapies. In April 2013, the College of Traditional Chinese Medicine Practitioners and Acupuncturists of Ontario was officially launched. Several factors account for the government’s decision to delegate self-regulatory authority to TCM/A practitioners through the creation of a regulatory college. In particular, the government’s decision seems to have been influenced by lobbying of some practitioners, greater public acceptance of alternative medicines, patient safety concerns related to acupuncture cases in the media, and the precedence of self-regulatory status being granted to these practitioners in other provinces. The degree to which the legislation has achieved its goals is difficult to determine given the short period of time the regulatory college has existed. However, the fact that the college has developed standards of practice to guide TCM/A practitioners and has a process in place to address public complaints is an early indication of movement toward achieving the policy’s goals.

  10. Recent Advances in Traditional Chinese Medicine for Kidney Disease.

    Science.gov (United States)

    Zhong, Yifei; Menon, Madhav C; Deng, Yueyi; Chen, Yiping; He, John Cijiang

    2015-09-01

    Because current treatment options for chronic kidney disease (CKD) are limited, many patients seek out alternative therapies such as traditional Chinese medicine. However, there is a lack of evidence from large clinical trials to support the use of traditional medicines in patients with CKD. Many active components of traditional medicine formulas are undetermined and their toxicities are unknown. Therefore, there is a need for research to identify active compounds from traditional medicines and understand the mechanisms of action of these compounds, as well as their potential toxicity, and subsequently perform well-designed, randomized, controlled, clinical trials to study the efficacy and safety of their use in patients with CKD. Significant progress has been made in this field within the last several years. Many active compounds have been identified by applying sophisticated techniques such as mass spectrometry, and more mechanistic studies of these compounds have been performed using both in vitro and in vivo models. In addition, several well-designed, large, randomized, clinical trials have recently been published. We summarize these recent advances in the field of traditional medicines as they apply to CKD. In addition, current barriers for further research are also discussed. Due to the ongoing research in this field, we believe that stronger evidence to support the use of traditional medicines for CKD will emerge in the near future.

  11. Treatment of Chinese Traditional Medicine Wastewater by Photosynthetic Bacteria

    Institute of Scientific and Technical Information of China (English)

    WANG You-zhi; WANG Feng-jun; BAO Li

    2005-01-01

    The influence factors treating wastewater of Chinese traditional medicine extraction by photosynthetic bacteria are tested and discussed. The results indicate that the method of photosynthetic bacteria can eliminate COD and BCD from wastewater in high efficiency. And it also has high load shock resistance. On the conditions of slight aerobic and semi-darkness, treating wastewater of Chinese traditional medicine extraction, the method has better efficiency to eliminate COD and BOD from the wastewater than those by anaerobic illumination and aerobic darkness treatments. After pretreatment of hydrolytic acidization, the removal rate of COD in the wastewater reached more than 85 %, and that rate of BOD reached more than 90% in the treating system of photosynthetic bacteria. It may be more feasible and advantageous than traditional anaerobic biological process to treat organic wastewater using PSB system.

  12. Traditional Chinese medicine for modern treatment of Parkinson's disease.

    Science.gov (United States)

    Han, Lu; Xie, Yuan-Hong; Wu, Rong; Chen, Chen; Zhang, Yan; Wang, Xiao-Ping

    2017-01-20

    Parkinson's disease (PD) is a chronic and progressive degenerative disorder of brain commonly seen among the elderly. As conventionally medical therapy is of limited relief and potential side effects, complementary and alternative medicine (CAM) has attracted growing public and professional attention. Therapies such as acupuncture, musical/rhythmic therapy and deep brain stimulation have been gradually proved positively in clinic. In this review, we retrospected the scientific or evidence-based-medicine advances of application and research for modern treatment of PD by CAM, especially traditional Chinese medicine in categories.

  13. Multi-disciplinary Research in Traditional Chinese Medicine--An Exploration

    Institute of Scientific and Technical Information of China (English)

    Mo Feizhi

    2005-01-01

    This paper discusses the present state of Traditional Chinese Medicine being divided into three leading lines of thought, namely, the Clinical line,the Integration of Western and Chinese Medicine line and the Development of Traditional Chinese Medicine line. It also describes the position of Traditional Chinese Medicine being a medical science rich in philosophy and wisdom and a culture centred upon medical science and technology. It outlines the basic characteristic of Traditional Chinese pointed out various flaws in methodology in Integration of Western and Chinese Medicine research. It also stresses that in order to make fruitful progress in the development of Traditional Chinese Medicine,multi-discipline research in Traditional Chinese Medicine should be made on a thoroughly understanding of the basic methodology of Traditional Chinese Medicine and follow its established principles.

  14. On the natural medical features of traditional Chinese medicine.

    Science.gov (United States)

    Zhu, Ming; Gong, Jiapei; Liu, Yuanlong

    2007-06-01

    Heaven-human-earth Pattern (HHE) regarded as a crucial conception of traditional Chinese medicine (TCM) has been applied extensively in TCM diagnostics, etiology, acupuncture therapeutics, materia medica and herbal formula, etc. It associates closely with Chinese classic cosmology. Since ancient time of China, many cosmic phenomena have been introduced to prove or illustrate TCM theories. Moreover, the five-element theory has been proven to be in keeping with some modern approaches of life provenance and life evolution. As a result, Chinese materia medica develops in a way of a pure natural medicine. It is of great significance that by realizing the natural features, the public nowadays can understand TCM better in its scientific connotations.

  15. Necessary conditions for the globalization of traditional Chinese medicine.

    Science.gov (United States)

    Yu, Bei-Bei; Gong, Xiu-Lin

    2011-03-01

    With the current trend of globalization, unprecedented opportunities and enormous changes have emerged for the global development of traditional Chinese medicine (TCM). However, many old and new challenges and problems still remain, including partial or limited comprehension of acupuncture, oriental medicine and TCM, the existence of non-standardized institutes of TCM and acupuncture training schools, unqualified TCM practitioners, and problems concerning Chinese herbal medicine and inexperience in conducting TCM business. These problems will doubtlessly impede the further development of TCM worldwide in the foreseeable future. It is also clear that the globalization of TCM will require a large scale systematic project and constitute an arduous historical task. This paper aims to consolidate 6 strategic development modes to reinforce and facilitate the process of TCM globalization through a detailed analysis of both the present status and existing problems concerning the development of TCM in the United States.

  16. Molecular Imaging in Traditional Chinese Medicine Therapy for Neurological Diseases

    OpenAIRE

    Zefeng Wang; Haitong Wan; Jinhui Li; Hong Zhang(Department of Physics and Center for Quantum Spacetime (CQUeST), Sogang University, 35 Baekbeom-ro, Mapo-gu, Seoul, 121-742 Korea); Mei Tian

    2013-01-01

    With the speeding tendency of aging society, human neurological disorders have posed an ever increasing threat to public health care. Human neurological diseases include ischemic brain injury, Alzheimer’s disease, Parkinson’s disease, and spinal cord injury, which are induced by impairment or specific degeneration of different types of neurons in central nervous system. Currently, there are no more effective treatments against these diseases. Traditional Chinese medicine (TCM) is focused on, ...

  17. Structure analysis of active components of traditional Chinese medicines

    DEFF Research Database (Denmark)

    Zhang, Wei; Sun, Qinglei; Liu, Jianhua

    2013-01-01

    Traditional Chinese Medicines (TCMs) have been widely used for healing of different health problems for thousands of years. They have been used as therapeutic, complementary and alternative medicines. TCMs usually consist of dozens to hundreds of various compounds, which are extracted from raw...... herbal sources by aqueous or alcoholic solvents. Therefore, it is difficult to correlate the pharmaceutical effect to a specific lead compound in the TCMs. A detailed analysis of various components in TCMs has been a great challenge for modern analytical techniques in recent decades. In this chapter...

  18. [Thought and method of reproductive toxicity research in traditional Chinese medicine].

    Science.gov (United States)

    Han, Jia-Yin; Yan, Yi; Liang, Ai-hua; Zhang, Yu-shi; Li, Chun-ying; Zhao, Yong; Lu, Yu-ting; Cui, Hong-yu; Li, Gui-qin

    2014-11-01

    Reproductive toxicity research takes an important place in traditional Chinese medicine pre-clinical safety evaluation. Modern reproductive toxicity experiment includes drug-related miscarriage, fetal death, teratism, and adverse effects on fertility, genital system, embryonic development and fetus, which is different from contraindicated in pregnancy in traditional Chinese medicine theory. Now the three-phases reproductive toxicity study is the method mainly applied in traditional Chinese medicine reproductive toxicity evaluation. Besides that, alternative methods of whole embryos culture and embryonic stem cell test are also used in traditional Chinese medicine embryo toxicity evaluation. This article reviews research progress and pre-clinical evaluation on reproductive toxicity of traditional Chinese medicine.

  19. The Origin of Traditional Chinese Medicine and Thinking on Chinese Medicine Development

    Institute of Scientific and Technical Information of China (English)

    Wang Wenkui; Wang Feng; Wang Ling

    2006-01-01

    Although the traditional Chinese medicine (TCM) has developed a profound theory system and a fame of outstanding advantage in curative effect, it seems that the TCM is not quite adaptable to the deveiopment and requirement of the modern society. A principle of "Adopting the advanced part of Western medicine to serve the TCM" should be adhered to for the traditional Chinese medicine. First, TCM should strive for a consensus of TCM theory which focuses on the guiding principles of "diagnosis and treatment based on an overall analysis of the illness and the patient's condition" and "the opposite principle of five internal organs". Among these principles, "keeping relative balance of three internal systems"is a valuable guidance of the diagnosis and treatment theory. Secondly, macroscopic should be integrated with microscopic, totality with parts, phenomenology with materialism. A dialectical law should be applied to guide analysis. In treatment,adjustment and balance are basic principles. It is necessary not only prepare the medicine in advance accoding to the predicted disease of the year, but also adopt methods to restrict disease in advance. Basides, TCM dose type should be ameliorated in order to meet the needs of society.

  20. Preliminary elaboration on emergent properties of traditional Chinese medicine.

    Science.gov (United States)

    Chai, Xing-yun

    2015-07-01

    Plant and animal derived secondary metabolites are the result of initiative and adaptability of natural evolution due to its adaptive stress responses. Based on countless attempts, rational thinking and thousands of years of clinical practice by ancient Chinese, the medicines were endowed with advantages for the treatment of diseases and keeping health balance through multiple components combination instead of single components, featured by a complex system with emergent properties. The emergence of traditional Chinese medicine is because of the integration of various components and its complex interactions. How to obtain the new multicomponent entities with the biological equivalent effect is an important and fundamental work for TCM-based new drug research and development. Currently, recognition of TCM emergence and development of related technical methods needs strengthened, and the understanding and research of TCM require a systematic integration of the holistic and reductive methods.

  1. Traditional Chinese Medicine Takes Effect in Treating AIDS

    Institute of Scientific and Technical Information of China (English)

    1995-01-01

    SINCE the first case of AIDS was found in the United States in June 1981, AIDS patients and persons infected with HIV have reached 17.41 million in the world. Among the more than four million AIDS patients, over two million have died. Currently, China has 1,435 patients infected with HIV. AIDS is a serious threat to health and the development of social economy, especially to women and children. Since there is still no effective cure for AIDS the death rate of AIDS patients is nearly 100 percent, many countries are trying to find medicines to combat this disease. Chinese doctors and researchers have made some progress in treating AIDS with traditional Chinese medicine. After numerous selections and

  2. Traditional Chinese medicine: potential for clinical treatment of rheumatoid arthritis.

    Science.gov (United States)

    Moudgil, Kamal D; Berman, Brian M

    2014-07-01

    Rheumatoid arthritis (RA) is a chronic debilitating autoimmune disease affecting people worldwide. Increasing numbers of RA patients in the west are resorting to various complementary and alternative medicine modalities for relief of symptoms and well-being. Herbal products and acupuncture representing traditional Chinese medicine (TCM) are two of the most commonly used forms of complementary and alternative medicine. Frequently, their efficacy against RA and safety have been inferred from anecdotal experience or pilot testing on a relatively small number of patients following inadequate study designs. Accordingly, significant efforts need to be invested in objectively testing TCM in clinical trials that are sufficiently powered, randomized, blinded, possess appropriate controls and follow standard criteria for assessment of the outcomes. In addition, the mechanisms underlying the immunomodulatory and other antiarthritic activities of TCM modalities need to be better defined. These efforts would help validate the scientific rationale for the use of TCM for the management of RA.

  3. Application of Traditional Chinese Medicine in Treatment of Atrial Fibrillation

    Science.gov (United States)

    Dong, Yan; Yao, Kuiwu; Jiang, Wenrui

    2017-01-01

    Atrial fibrillation (AF) is the most common cardiac arrhythmia, which is related to many cardiac and cerebral vascular diseases, especially stroke. It can therefore increase cardiovascular mortality and all-cause death. The current treatments of AF remain to be western drugs and radiofrequency ablation which are limited by the tolerance of patients, adverse side effects, and high recurrence rate, especially for the elderly. On the contrary, traditional Chinese medicine (TCM) with long history of use involves various treatment methods, including Chinese herbal medicines (CHMs) or bioactive ingredients, Chinese patent medicines, acupuncture, Qigong, and Tai Chi Chuan. With more and more researches reported, the active roles of TCM in AF management have been discovered. Then it is likely that TCM would be effective preventive means and valuable additional remedy for AF. The potential mechanisms further found by numerous experimental studies showed the distinct characteristics of TCM. Some CHMs or bioactive ingredients are atrial-selective, while others are multichannel and multifunctional. Therefore, in this review we summarized the treatment strategies reported in TCM, with the purpose of providing novel ideas and directions for AF management. PMID:28243308

  4. Application of Traditional Chinese Medicine in Treatment of Atrial Fibrillation

    Directory of Open Access Journals (Sweden)

    Yan Dong

    2017-01-01

    Full Text Available Atrial fibrillation (AF is the most common cardiac arrhythmia, which is related to many cardiac and cerebral vascular diseases, especially stroke. It can therefore increase cardiovascular mortality and all-cause death. The current treatments of AF remain to be western drugs and radiofrequency ablation which are limited by the tolerance of patients, adverse side effects, and high recurrence rate, especially for the elderly. On the contrary, traditional Chinese medicine (TCM with long history of use involves various treatment methods, including Chinese herbal medicines (CHMs or bioactive ingredients, Chinese patent medicines, acupuncture, Qigong, and Tai Chi Chuan. With more and more researches reported, the active roles of TCM in AF management have been discovered. Then it is likely that TCM would be effective preventive means and valuable additional remedy for AF. The potential mechanisms further found by numerous experimental studies showed the distinct characteristics of TCM. Some CHMs or bioactive ingredients are atrial-selective, while others are multichannel and multifunctional. Therefore, in this review we summarized the treatment strategies reported in TCM, with the purpose of providing novel ideas and directions for AF management.

  5. [Application of Delphi method in traditional Chinese medicine clinical research].

    Science.gov (United States)

    Bi, Ying-fei; Mao, Jing-yuan

    2012-03-01

    In recent years, Delphi method has been widely applied in traditional Chinese medicine (TCM) clinical research. This article analyzed the present application situation of Delphi method in TCM clinical research, and discussed some problems presented in the choice of evaluation method, classification of observation indexes and selection of survey items. On the basis of present application of Delphi method, the author analyzed the method on questionnaire making, selection of experts, evaluation of observation indexes and selection of survey items. Furthermore, the author summarized the steps of application of Delphi method in TCM clinical research.

  6. [Application of zebra fishes in studies on traditional Chinese medicines].

    Science.gov (United States)

    Tian, Li-li; Zhu, Guo-fu

    2015-03-01

    The zebra fish model, as an integral animal model, features small volume, high throughput, low cost, short cycle and reliable experimental results, thus has been widely used in medical studies. Traditional Chinese medicines (TCM) constitute a complex system, their active ingredients and action mechanisms are among study hotspots in during the development of modern TCMs. Along with the constant improvement of advanced technologies and methods, zebra fishes have been increasingly applied in studies on TCMs and shown advantages in active screening, and toxicity and metabolism studies. In this paper, TCM studies by using zebra fishes in recent years are summarized to provide new ideas and methods for basic studies on TCMs.

  7. Use frequency of traditional Chinese medicine in Taiwan

    Directory of Open Access Journals (Sweden)

    Chen Yu-Chun

    2007-02-01

    Full Text Available Abstract Background Use of Traditional Chinese medicine (TCM, an important category of complementary and alternative medicine (CAM, has increased substantially in Western countries during the past decade. Use of TCM is also widespread in the Chinese population. However, few informative data have been obtained to date by large-scale investigations of TCM use in the Chinese population. This study was aimed at elucidating the demographics and patterns of TCM use in Taiwan. Methods We employed the complete datasets of TCM outpatient reimbursement claims from 1996 to 2001, including the use of Chinese herbal remedies, acupuncture and traumatology manipulative therapy, to analyse use frequencies, the characteristics of TCM users, and the disease categories that were treated by TCM in Taiwan. Results At the end of 2001, 6,142,829 (28.4% among the 21,653,555 valid beneficiaries of the National Health Insurance in Taiwan had used TCM during the year. However, 13,536,266 subjects (62.5% had used TCM at least once during the whole 6-year period from 1996 to 2001, with a total of 156,224,266 visits (mean 11.5 visits per user. The mean number of TCM users per annum was 5,733,602, with a mean increment of 1,671,476 (29.2% of new users yearly. Among TCM users, female was higher than male (female:male = 1.13:1, and the age distribution displayed a peak at around the 30s, followed by the 20s and 40s. Chinese herbal remedies (85.9% were the most common TCM modality used by this population, followed by acupuncture (11.0% and traumatology manipulative therapies (3.1%. Private TCM clinics provided most of the TCM care (82.6%, followed by private TCM hospitals (12.0%. The top ten major disease categories for TCM visits were diseases of the respiratory system, musculoskeletal system and connective tissue; symptoms, signs and ill-defined conditions; injury and poisoning; diseases of the digestive system, genitourinary system, skin and subcutaneous tissue, nervous

  8. The quest for modernisation of traditional Chinese medicine

    Science.gov (United States)

    2013-01-01

    Traditional Chinese medicine (TCM) is an integral part of mainstream medicine in China. Due to its worldwide use, potential impact on healthcare and opportunities for new drug development, TCM is also of great international interest. Recently, a new era for modernisation of TCM was launched with the successful completion of the Good Practice in Traditional Chinese Medicine Research in the Post-genomic Era (GP-TCM) project, the European Union’s Seventh Framework Programme (FP7) coordination action on TCM research. This 3.5-year project that involved inputs from over 200 scientists resulted in the production of 20 editorials and in-depth reviews on different aspects of TCM that were published in a special issue of Journal of Ethnopharmacology (2012; volume 140, issue 3). In this narrative review, we aim to summarise the findings of the FP7 GP-TCM project and highlight the relevance of TCM to modern medicine within a historical and international context. Advances in TCM research since the 1950s can be characterised into three phases: Phase I (1950s-1970s) was fundamental for developing TCM higher education, research and hospital networks in China; Phase II (1980s-2000s) was critical for developing legal, economic and scientific foundations and international networks for TCM; and Phase III (2011 onwards) is concentrating on consolidating the scientific basis and clinical practice of TCM through interdisciplinary, interregional and intersectoral collaborations. Taking into account the quality and safety requirements newly imposed by a globalised market, we especially highlight the scientific evidence behind TCM, update the most important milestones and pitfalls, and propose integrity, integration and innovation as key principles for further modernisation of TCM. These principles will serve as foundations for further research and development of TCM, and for its future integration into tomorrow’s medicine. PMID:23763836

  9. The quest for modernisation of traditional Chinese medicine.

    Science.gov (United States)

    Xu, Qihe; Bauer, Rudolf; Hendry, Bruce M; Fan, Tai-Ping; Zhao, Zhongzhen; Duez, Pierre; Simmonds, Monique S J; Witt, Claudia M; Lu, Aiping; Robinson, Nicola; Guo, De-an; Hylands, Peter J

    2013-06-13

    Traditional Chinese medicine (TCM) is an integral part of mainstream medicine in China. Due to its worldwide use, potential impact on healthcare and opportunities for new drug development, TCM is also of great international interest. Recently, a new era for modernisation of TCM was launched with the successful completion of the Good Practice in Traditional Chinese Medicine Research in the Post-genomic Era (GP-TCM) project, the European Union's Seventh Framework Programme (FP7) coordination action on TCM research. This 3.5-year project that involved inputs from over 200 scientists resulted in the production of 20 editorials and in-depth reviews on different aspects of TCM that were published in a special issue of Journal of Ethnopharmacology (2012; volume 140, issue 3). In this narrative review, we aim to summarise the findings of the FP7 GP-TCM project and highlight the relevance of TCM to modern medicine within a historical and international context. Advances in TCM research since the 1950s can be characterised into three phases: Phase I (1950s-1970s) was fundamental for developing TCM higher education, research and hospital networks in China; Phase II (1980s-2000s) was critical for developing legal, economic and scientific foundations and international networks for TCM; and Phase III (2011 onwards) is concentrating on consolidating the scientific basis and clinical practice of TCM through interdisciplinary, interregional and intersectoral collaborations. Taking into account the quality and safety requirements newly imposed by a globalised market, we especially highlight the scientific evidence behind TCM, update the most important milestones and pitfalls, and propose integrity, integration and innovation as key principles for further modernisation of TCM. These principles will serve as foundations for further research and development of TCM, and for its future integration into tomorrow's medicine.

  10. Promoting the Development of Traditional Chinese Medicine in the New Century

    Institute of Scientific and Technical Information of China (English)

    佘静

    2001-01-01

    @@Reviewing the past, traditional Chinese medicine (TCM) in the 20th century experienced vicissitude. Since the founding the People's Republic of China, especially for the past twenty years, traditional Chinese medicine undertaking, full of vigor and vitality, has made an unprecedented development in China. The legal status and scientific status of traditional Chinese medicine and pharmacology have already been established. The medical system of traditional Chinese medicine, which is composed of traditional Chinese medicine hospitals, ethnic minority medicine hospitals, integration of traditional and western medicine hospitals and comprehensive hospitals, is playing an important role in preventing, treating diseases and enhancing people's health level. The system of production and circulation for traditional Chinese medicine has basically guaranteed the people's demand for Chinese medicine, with the principles of producing medicinal materials as basis, taking Chinese medicine industry as pillar and Chinese medicine as link. Remarkable achievements have been scored in the research of TCM development as well as research of TCM basic theory and clinical treatment. A number of scientific and technological results have been transformed into productive forces. TCM education has formed a rational pattern based on inheriting traditional way of transmission from master to disciple as well as taking the university and college education as the main part. Minority medical science has been further explored and sorted out; the level of medical treatment, teaching and scientific research for ethnic minority medicines has been improved. As the contingent of integrated traditional and western medicine is growing steadily, medical treatment system, scientific research system and teaching system for integrated traditional and western medicine takes shape progressively. International exchange and cooperation on traditional Chinese medicine has been greatly promoted. Various forms of

  11. Reason Analysis and Risk Prevention of Soaring Price of Traditional Chinese Medicinal Materials

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    In recent years,the price of traditional Chinese medicinal materials soars continuously,and the resulting price risk increasingly looms large,which has critically affected midstream and downstream industries and peoples’ demand for drug,and imperiled healthy and orderly development of traditional Chinese medicinal industries.Based on the status quo of continuous skyrocketing price of traditional Chinese medicinal materials at present,we winkle out the root cause of soaring price as follows:the supply and demand lose balance;the production costs hike up;there are other factors responsible for soaring price.This paper further analyses the impact of sharp increase in price of traditional Chinese medicinal materials on all links of industry chain as follows:the medicinal herb growers never benefit from soaring price;the counterfeiters and forgers in midstream industry increase;the gross profit rate of Chinese medicine enterprises declines.In accordance with the risk arising from abnormal fluctuation in price of traditional Chinese medicinal materials,corresponding precautionary measures are put forward as follows:promote the quality of traditional Chinese medicinal materials through management of value chain;curtail the production and management cost of traditional Chinese medicinal materials through management of organization chain;stabilize price of traditional Chinese medicinal materials through management of information chain;reduce transaction cost of traditional Chinese medicinal materials through management of logistics chain.

  12. [Preliminary study on main impacting factors on brand equity of listed traditional Chinese medicine companies].

    Science.gov (United States)

    Tan, Wei; Geng, Dong-Mei; Rong, Xue; Li, Zi; Liu, Wei; Yang, Li; Xu, Si-Qun; Jie, Xiao-Qian

    2013-05-01

    The brand equity is valuable intangible assets of traditional Chinese medicine companies, who are excellent representatives of traditional Chinese medicine enterprises and the most promising ones to good international medicine brands. However, there is still no systematic study on how to correctly evaluate the brand equity of listed traditional Chinese medicine companies at present. To make it clear, the main impacting factors on brand equity of listed traditional Chinese medicine companies, both structured open outline pre-research and closed questionnaire research were adopted for the field survey, and some suggestions for how to protect and enhance the brand equity were also presented on the basis of survey and analysis, in the hope of improving the brand management level of listed traditional Chinese medicine companies, and making a beneficial exploration for the development of brand theory of the traditional Chinese medicine industry.

  13. Barriers and countermeasures in developing traditional Chinese medicine in Europe.

    Science.gov (United States)

    Liu, Yunfang; Yang, Zhiping; Cheng, Jing; Fan, Daiming

    2016-09-01

    Traditional Chinese medicine (TCM) is one of the unique cultural treasures of Chinese; it represents a significant feature and prominent advantage of the healthcare cause in China. Data in this paper were fromWorld Health Organization, Chinese Bureau of Statistics, China National Knowledge Infrastructure, and PubMed. In recent years, TCM has established a solid foundation in Europe, which made great strides in legislation, education, research, and international exchange, and has enjoyed a vast development space in the continent. Now, TCM is embracing unprecedented development opportunities in Europe. At the same time, the stiff international competition poses a grave threat to China's TCM industry. With multiple cultural, legal, and institutional challenges, as well as talent shortages in the way, TCM is now facing many difficulties in Europe. To fully prepare and enact active and vigorous steps to seize opportunities, we should have a clear picture about the serious challenges hampering TCM development in Europe. The TCM development at overseas markets has shifted from a spontaneous trade activity into a national strategy spearheaded by the government and participated in by multiple stakeholders. We should make a systematic, comprehensive, and sustainable push in fields such as TCM therapy, healthcare, education, research, culture, and industry development. The ultimate goal is to bring TCMs to the global market and allow them to play a role in safeguarding public health along with modern medicines.

  14. Registered nurses integrate traditional Chinese medicine into the triage process.

    Science.gov (United States)

    Bertrand, Sharon W

    2012-02-01

    People in the United States often consult registered nurses (nurses) for advice when they want to explore alternatives to Western medicine, such as traditional Chinese medicine (TCM). Nurses find themselves confronting dilemmas when they are caught between these radically different worlds of medical cultures and thinking. Twenty Minnesota nurses were interviewed to learn how they integrate TCM into their triage process. Symbolic interactionism was the research framework used, and mixed coding methods facilitated data analysis. Several sociological theories explain the findings. The major finding is that nurses use a four-step triage process that begins from the Western medical perspective and includes consideration of TCM use. Nurses' recommendations are influenced by their situational roles and relationships, and by the cues they read from the person who is asking their advice. The results point to nurses being natural disseminators of TCM information and education in their resource role for others making health care decisions.

  15. Concept of Mind and Brain in Traditional Chinese Medicine

    Directory of Open Access Journals (Sweden)

    Kaoru Sakatani

    2007-04-01

    Full Text Available In Traditional Chinese Medicine (TCM, the functions of the brain are dispersed to five zang organs, and are maintained by comprehensive functional interactions among the five zang organs. Therefore, brain diseases are regarded as systematic diseases in TCM, and their treatments are aimed to normalize not only the activity of the organs, but also the balance of functional interaction. In addition, interestingly, the functional interaction between the five zang organs in TCM resembles a biological model based on chaos theory. These features of TCM derive from its theoretical basis in Yin-Yang and the five elements. In conclusion, TCM had co-opted the basic idea of a complex system for the diagnosis and treatment of human diseases thousands years ago. Research into TCM should not only evaluate the effects of herbal medicine or acupuncture, but should take into consideration the view of human beings in TCM.

  16. Challenges in Research and Development of Traditional Chinese Medicines

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    This review is briefly to recall the history of research and development (R&D) of Chinese materia medica (CMM) and to discuss the challenges of Chinese traditional and herbal medicines (CTHM) facing the modern science and technology. The R&D of CTHM is thought to be an important pathway for new drug discovery. Since1949, about 140 approved new drugs have been developed, among which about 80 originated directly or indirectly from medicinal plants. CTHM has gained interest from the international medical, biomedical, and pharmaceutical institutions as a valuable source of potential medicines. For the modernization of CMM and innovative research of CTHM, there are following challenges to be faced: (1) to evaluate the efficacy, pharmacological properties, action mechanism, and active chemical constituents; (2) to develop new methodologies for the quality and safety of CTHM; (3) to apply new "-omics" techniques to accelerate drug discoveries developed from CTHM; and (4) to apply international practices including good agricultural practice, good manufacturing practice, good laboratory practice, and good clinical practice in the R&D of CTHM.

  17. [Process on researching methods of ecology of Chinese traditional medicine resources].

    Science.gov (United States)

    Zhou, Yingqun; Cao, Hailu; Zhao, Runhuai; Chen, Shilin

    2011-02-01

    Though the study on ecology of Chinese traditional medicinal resources methods has achieved great progress in recent years, it is not able to catch the pace of the development of ecology science. Based on the analysis of recent literatures about ecology development trend and Chinese traditional medicinal ecology methods, the progress of Chinese traditional medicinal ecology methods was reviewed, and future study trend was discussed.

  18. Clinical research of traditional Chinese medicine in big data era.

    Science.gov (United States)

    Zhang, Junhua; Zhang, Boli

    2014-09-01

    With the advent of big data era, our thinking, technology and methodology are being transformed. Data-intensive scientific discovery based on big data, named "The Fourth Paradigm," has become a new paradigm of scientific research. Along with the development and application of the Internet information technology in the field of healthcare, individual health records, clinical data of diagnosis and treatment, and genomic data have been accumulated dramatically, which generates big data in medical field for clinical research and assessment. With the support of big data, the defects and weakness may be overcome in the methodology of the conventional clinical evaluation based on sampling. Our research target shifts from the "causality inference" to "correlativity analysis." This not only facilitates the evaluation of individualized treatment, disease prediction, prevention and prognosis, but also is suitable for the practice of preventive healthcare and symptom pattern differentiation for treatment in terms of traditional Chinese medicine (TCM), and for the post-marketing evaluation of Chinese patent medicines. To conduct clinical studies involved in big data in TCM domain, top level design is needed and should be performed orderly. The fundamental construction and innovation studies should be strengthened in the sections of data platform creation, data analysis technology and big-data professionals fostering and training.

  19. Molecular imaging in traditional Chinese medicine therapy for neurological diseases.

    Science.gov (United States)

    Wang, Zefeng; Wan, Haitong; Li, Jinhui; Zhang, Hong; Tian, Mei

    2013-01-01

    With the speeding tendency of aging society, human neurological disorders have posed an ever increasing threat to public health care. Human neurological diseases include ischemic brain injury, Alzheimer's disease, Parkinson's disease, and spinal cord injury, which are induced by impairment or specific degeneration of different types of neurons in central nervous system. Currently, there are no more effective treatments against these diseases. Traditional Chinese medicine (TCM) is focused on, which can provide new strategies for the therapy in neurological disorders. TCM, including Chinese herb medicine, acupuncture, and other nonmedication therapies, has its unique therapies in treating neurological diseases. In order to improve the treatment of these disorders by optimizing strategies using TCM and evaluate the therapeutic effects, we have summarized molecular imaging, a new promising technology, to assess noninvasively disease specific in cellular and molecular levels of living models in vivo, that was applied in TCM therapy for neurological diseases. In this review, we mainly focus on applying diverse molecular imaging methodologies in different TCM therapies and monitoring neurological disease, and unveiling the mysteries of TCM.

  20. [Changes and establishment of the principle of "Unity of traditional Chinese medicine and western medicine"].

    Science.gov (United States)

    Li, Jian

    2014-11-01

    "Unity of traditional Chinese and western medicine" was one of the three major health work principles at the early founding of the People's Republic of China. It was not only a choice of political strategy in line with the lack of contemporary health-care resources, but also a part of the revolutionary heritage for more than 20 years in the process of the Chinese Communist Party from the preliminary "application of both traditional and western medicine" to the making of the principles of both "cooperation of traditional Chinese and western medicine" and "unity of traditional Chinese and western medicine". All this was closely related to the concrete environment of the Chinese health work of various stages of Yan'an period with strong revolutionary atmosphere and was not the professional demand of the health workers, rather, this principle set up in 1950 was the result of the careful consideration of Mao Zedong and an adjustment guided under the revolutionary framework of Neo-democracy set up under the guidance of the Common Principle which was a bettered adaptation to the contemporary national condition.

  1. A Survey on Treatment of Dry Eye by Traditional Chinese Medicine and Integrative Chinese and Western Medicine

    Institute of Scientific and Technical Information of China (English)

    ZHOU Wan-yu; LI Yue-hong

    2006-01-01

    Dry eye is now one of the most common superficial disorders in ophthalmology at home and abroad, and more and more people attach importance to the study. The ideal approach for treatment of dry eye is to normalize the condition by rebuilding the superficial circumstance of the eye, and to make tear film work as well as possible so as to relieve the irritating symptoms in the eye. The authors are making a comprehensive discussion on the methods and curative effects of treating dry eye by traditional Chinese medicine and by integrative Chinese and Western medicine in recent years, so as to introduce the distinctive features of the traditional Chinese medicine and integrative Chinese and Western medicine in this field.

  2. Navigating traditional chinese medicine network pharmacology and computational tools.

    Science.gov (United States)

    Yang, Ming; Chen, Jia-Lei; Xu, Li-Wen; Ji, Guang

    2013-01-01

    The concept of "network target" has ushered in a new era in the field of traditional Chinese medicine (TCM). As a new research approach, network pharmacology is based on the analysis of network models and systems biology. Taking advantage of advancements in systems biology, a high degree of integration data analysis strategy and interpretable visualization provides deeper insights into the underlying mechanisms of TCM theories, including the principles of herb combination, biological foundations of herb or herbal formulae action, and molecular basis of TCM syndromes. In this study, we review several recent developments in TCM network pharmacology research and discuss their potential for bridging the gap between traditional and modern medicine. We briefly summarize the two main functional applications of TCM network models: understanding/uncovering and predicting/discovering. In particular, we focus on how TCM network pharmacology research is conducted and highlight different computational tools, such as network-based and machine learning algorithms, and sources that have been proposed and applied to the different steps involved in the research process. To make network pharmacology research commonplace, some basic network definitions and analysis methods are presented.

  3. Navigating Traditional Chinese Medicine Network Pharmacology and Computational Tools

    Directory of Open Access Journals (Sweden)

    Ming Yang

    2013-01-01

    Full Text Available The concept of “network target” has ushered in a new era in the field of traditional Chinese medicine (TCM. As a new research approach, network pharmacology is based on the analysis of network models and systems biology. Taking advantage of advancements in systems biology, a high degree of integration data analysis strategy and interpretable visualization provides deeper insights into the underlying mechanisms of TCM theories, including the principles of herb combination, biological foundations of herb or herbal formulae action, and molecular basis of TCM syndromes. In this study, we review several recent developments in TCM network pharmacology research and discuss their potential for bridging the gap between traditional and modern medicine. We briefly summarize the two main functional applications of TCM network models: understanding/uncovering and predicting/discovering. In particular, we focus on how TCM network pharmacology research is conducted and highlight different computational tools, such as network-based and machine learning algorithms, and sources that have been proposed and applied to the different steps involved in the research process. To make network pharmacology research commonplace, some basic network definitions and analysis methods are presented.

  4. Functional Somatic Syndromes: Emerging Biomedical Models and Traditional Chinese Medicine

    Directory of Open Access Journals (Sweden)

    Steven Tan

    2004-01-01

    Full Text Available The so-called functional somatic syndromes comprise a group of disorders that are primarily symptom-based, multisystemic in presentation and probably involve alterations in mind-brain-body interactions. The emerging neurobiological models of allostasis/allostatic load and of the emotional motor system show striking similarities with concepts used by Traditional Chinese Medicine (TCM to understand the functional somatic disorders and their underlying pathogenesis. These models incorporate a macroscopic perspective, accounting for the toll of acute and chronic traumas, physical and emotional stressors and the complex interactions between the mind, brain and body. The convergence of these biomedical models with the ancient paradigm of TCM may provide a new insight into scientifically verifiable diagnostic and therapeutic approaches for these common disorders.

  5. Research advances in traditional Chinese medicine syndromes in cancer patients.

    Science.gov (United States)

    Ji, Qing; Luo, Yun-quan; Wang, Wen-hai; Liu, Xuan; Li, Qi; Su, Shi-bing

    2016-01-01

    Traditional Chinese medicine (TCM) syndrome, also known as TCM ZHENG or TCM pattern, is an integral and essential part of TCM theory that helps to guide the design of individualized treatments. A TCM syndrome, in essence, is a characteristic profile of all clinical manifestations in one patient that can be readily identified by a TCM practitioner. In this article, the authors reviewed the presentations of TCM syndromes in seven common malignancies (liver, lung, gastric, breast, colorectal, pancreatic and esophageal cancers), the objectivity and the standardization of TCM syndrome differentiation, the evaluation of TCM syndrome modeling in cancer research, and syndrome differentiation-guided TCM treatment of cancers. A better understanding of TCM syndrome theory, as well as its potential biological basis, may contribute greatly to the clinical TCM diagnosis and the treatment of cancer.

  6. [Discuss of efficacy study to traditional Chinese medicine complex prescription].

    Science.gov (United States)

    Guo, Li-Li; Wang, Jie

    2008-04-01

    There are many differences between traditional Chinese medicine (TCM) and western medicine, and the use of TCM has its feature under the guide of TCM theory. Determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs is the base of TCM treatment, the main form of TCM apply is compatibility, formula corresponding differentiation of symptoms and signs is the key for TCM to get better effects, integrated adjustment is the TCM mode of action. All above determined the methods and standards to evaluate the pharmacodynamic effect of TCM cannot completely accord to Western medicine. Use modern technology and combine the feature of TCM to estabilish the method for effects evaluation and standard system of TCM, which is the key point to correctly appraise the effects of TCM. Stabilized quality control is the precondition of pharmacodynamic action appraisement, animal models combined disease and symptoms are the necessary tools for effect appraisement, integrated adjustment need mutiple index to appraise pharmacodynamic action, the method to avoid subjective error in TCM reseach is using mathematical model and parameter to scientificly analyse data, also the explaination of mechanism of action need standard clinical pharmacology experimental date.

  7. [Problems in quality standard research of new traditional Chinese medicine compound].

    Science.gov (United States)

    Zhou, Gang; He, Yan-Ping

    2014-09-01

    The new traditional Chinese medicine compound is the main part of the research of new drug of traditional Chinese medicine (TCM), and the new Chinese herbal compound reflects the characteristics of TCM theory. The new traditional Chinese medicine compound quality standard research is one of the main content of pharmaceutical research, and is also the focus of the new medicine pharmaceutical evaluation content. Although in recent years the research level of new traditional Chinese medicine compound has been greatly improved, but the author during the review found still some common problems existing in new traditional Chinese medicine compound quality standard research data, this paper analyzed the current quality standards for new traditional Chinese medicine compound and the problems existing in the research data, respectively from measurement of the content of index selection, determine the scope of the content, and the quality standard design concept, the paper expounds developers need to concern. The quality of new traditional Chinese medicine compound quality standard is not only itself can be solved, but quality standards is to ensure the key and important content of product quality, improving the quality of products cannot do without quality standards. With the development of science and technology, on the basis of quality by design under the guidance of the concept, new traditional Chinese medicine compound quality standard system will be more scientific, systematic and perfect.

  8. Regulating Traditional Chinese Medicine Practitioners and Acupuncturists in Ontario, Canada

    Directory of Open Access Journals (Sweden)

    Glen E. Randall

    2015-12-01

    Full Text Available In 2006, the Ontario government passed the Traditional Chinese Medicine Act, which granted Traditional Chinese Medicine practitioners and Acupuncturists (TCM/A practitioners self-regulatory status under the Regulated Health Professions Act, 1991. The goal of the legislation was to create a new regulatory college that would set and enforce high standards of care and safety in order to enhance public protection and access to a range of traditional and alternative therapies. In April 2013, the College of Traditional Chinese Medicine Practitioners and Acupuncturists of Ontario was officially launched. Several factors account for the government’s decision to delegate self-regulatory authority to TCM/A practitioners through the creation of a regulatory college. In particular, the government’s decision seems to have been influenced by lobbying of some practitioners, greater public acceptance of alternative medicines, patient safety concerns related to acupuncture cases in the media, and the precedence of self-regulatory status being granted to these practitioners in other provinces. The degree to which the legislation has achieved its goals is difficult to determine given the short period of time the regulatory college has existed. However, the fact that the college has developed standards of practice to guide TCM/A practitioners and has a process in place to address public complaints is an early indication of movement toward achieving the policy’s goals. Le gouvernement de l'Ontario a fait voter en 2006 la Loi sur les praticiens en médecine traditionnelle chinoise, qui accorde aux praticiens en médecine traditionnelle chinoise et aux acupuncteurs (praticiens en MTC/A le statut de profession autonome dans le cadre la Loi sur les professions de la santé réglementées de 1991. Le but de la Loi était de créer un ordre professionnel capable d'établir et appliquer des normes de qualité et de sécurité des soins, ceci dans le but d

  9. Searching for a Cure: The FDA's Regulatory Approach to Traditional Chinese Herbal Medicine

    OpenAIRE

    Kim, Anna L.

    1997-01-01

    I will begin this discussion by describing traditional Chinese medicine and how it compares to the Western medical tradition. Second, I will then examine why regulation is necessary given the impact of Chinese herbal medicine on American healthcare. Then, I will proceed to the problem of trying to fit a square peg into a round hole, namely, the issue of regulating Chinese herbal medicine under current statutory provisions. Fourth, I will analyze state and federal responses to alternative ther...

  10. Network pharmacology: a Rosetta Stone for traditional Chinese medicine.

    Science.gov (United States)

    Hao, Da Cheng; Xiao, Pei Gen

    2014-08-01

    Network pharmacology, based on the theory of systems biology, is a new discipline that analyzes the biological network and screens out the nodes of particular interest, with the aim of designing poly-target drug molecule. It emphasizes maximizing drug efficacy and minimizing adverse effect via the multiple regulation of the signaling pathway. Coincidentally, almost all traditional Chinese medicine (TCM) and worldwide ethnomedicine exert therapeutic effect by targeting multiple molecules of the human body. In this overview, we offer a critique on the present perception of TCM and network pharmacology; illustrate the utility of network pharmacology in the study of single herb, medicine pair, and TCM formula; and summarize the recent progress of TCM-based drug discovery inspired by network pharmacology. Network pharmacology could be of great help in decreasing drug attrition rate and thus is essential in rational and cost-effective drug development. We also pinpoint the current TCM issues that could be tackled by the flexible combined use of network pharmacology and relevant disciplines.

  11. Management of SAH with traditional Chinese medicine in China.

    Science.gov (United States)

    Wang, Chunxue; Zhao, Xingquan; Mao, Shujing; Wang, Yongjun; Cui, Xiangning; Pu, Yuehua

    2006-06-01

    China lacks large scale authorized epidemiological study results in allusion to subarachnoid hemorrhage (SAH) within recent 15 years since MONICA (multinational monitoring of trends and determinants in cardiovascular disease) study revealed SAH situation in China in 2000. The main cause of SAH in China is aneurysm which takes up 30-50%, while over 90% aneurysm locates at Willis circle. Early surgery for SAH after aneurysm rupture is the dominant procedure to deal with SAH in China. Moreover, calcium antagonists rank the absolute leading position for cerebral vascular spasm (CVS) among medication-based treatment options. However, traditional Chinese medicine such as Salvia miltiorrhiza, Acanthopanax senticosus, Ginkgo biloba, Pueraria lobata, Liguisticum chuanxiong, cow bezoar, Diospyros kaki and Gynostemma pentaphyllum have been proven beneficial in CVS prevention and treatment, while Salvia miltiorrhiza and TCM soup have unique effects on bleeding absorption. In addition, aescine and some TCM soup might relieve strong headache after SAH. In general, TCM integrated with western medicine have shown unique advantages in the current treatment of SAH in China. However, it is a pity that China still lacks larger scale randomized controlled trials and research on SAH treatment focusing on TCM and the related mechanism of TCM on SAH still need to be investigated further.

  12. The roles of traditional Chinese medicine in gene therapy.

    Science.gov (United States)

    Ling, Chang-quan; Wang, Li-na; Wang, Yuan; Zhang, Yuan-hui; Yin, Zi-fei; Wang, Meng; Ling, Chen

    2014-03-01

    The field of gene therapy has been increasingly studied in the last four decades, and its clinical application has become a reality in the last 15 years. Traditional Chinese medicine (TCM), an important component of complementary and alternative medicine, has evolved over thousands of years with its own unique system of theories, diagnostics and therapies. TCM is well-known for its various roles in preventing and treating infectious and chronic diseases, and its usage in other modern clinical practice. However, whether TCM can be applied alongside gene therapy is a topic that has not been systematically examined. Here we provide an overview of TCM theories in relation to gene therapy. We believe that TCM theories are congruent with some principles of gene therapy. TCM-derived drugs may also act as gene therapy vehicles, therapeutic genes, synergistic therapeutic treatments, and as co-administrated drugs to reduce side effects. We also discuss in this review some possible approaches to combine TCM and gene therapy.

  13. Applications of dynamical complexity theory in traditional Chinese medicine.

    Science.gov (United States)

    Ma, Yan; Sun, Shuchen; Peng, Chung-Kang

    2014-09-01

    Traditional Chinese medicine (TCM) has been gradually accepted by the world. Despite its widespread use in clinical settings, a major challenge in TCM is to study it scientifically. This difficulty arises from the fact that TCM views human body as a complex dynamical system, and focuses on the balance of the human body, both internally and with its external environment. As a result, conventional tools that are based on reductionist approach are not adequate. Methods that can quantify the dynamics of complex integrative systems may bring new insights and utilities about the clinical practice and evaluation of efficacy of TCM. The dynamical complexity theory recently proposed and its computational algorithm, Multiscale Entropy (MSE) analysis, are consistent with TCM concepts. This new system level analysis has been successfully applied to many health and disease related topics in medicine. We believe that there could be many promising applications of this dynamical complexity concept in TCM. In this article, we propose some promising applications and research areas that TCM practitioners and researchers can pursue.

  14. The Progress of Metabolomics Study in Traditional Chinese Medicine Research.

    Science.gov (United States)

    Wang, Pengcheng; Wang, Qiuhong; Yang, Bingyou; Zhao, Shan; Kuang, Haixue

    2015-01-01

    Traditional Chinese medicine (TCM) has played important roles in health protection and disease treatment for thousands of years in China and has gained the gradual acceptance of the international community. However, many intricate issues, which cannot be explained by traditional methods, still remain, thus, new ideas and technologies are needed. As an emerging system biology technology, the holistic view adopted by metabolomics is similar to that of TCM, which allows us to investigate TCM with complicated conditions and multiple factors in depth. In this paper, we tried to give a timely and comprehensive update about the methodology progression of metabolomics, as well as its applications, in different fields of TCM studies including quality control, processing, safety and efficacy evaluation. The herbs investigated by metabolomics were selected for detailed examination, including Anemarrhena asphodeloides Bunge, Atractylodes macrocephala Kidd, Pinellia ternate, etc.; furthermore, some valuable results have been obtained and summarized. In conclusion, although the study of metabolomics is at the early phase and requires further scrutiny and validation, it still provides bright prospects to dissect the synergistic action of multiple components from TCM. Overall, with the further development of analytical techniques, especially multi-analysis techniques, we expect that metabolomics will greatly promote TCM research and the establishment of international standards, which is beneficial to TCM modernization.

  15. New trends for clinical research of traditional Chinese medicine in China

    Institute of Scientific and Technical Information of China (English)

    SHANG Hong-cai; LI You-ping; CHEN Jing; ZHANG Jun-hua; ZHANG Bo-li

    2008-01-01

    @@ To the Editor: In former times, traditional Chinese medicine (TCM) individualized its treatment protocol or clinical practice without considering the principles of modern medicine.The standard methodology of random selection, blinding and placebo control, followed by statistical analysis was generally overlooked. This had a negative effect on the development of TCM.Recently, the volume of applied research in Chinese medicine is growing rapidly and the quality is improving.1 There is good evidence supporting the use of some Chinese patent medicine treatments.2-4 Further, there is a more open attitude to Chinese medicine among conventional health professionals, partly explained by the rise of evidence-based medicine (EBM).

  16. [Applications of mathematical statistics methods on compatibility researches of traditional Chinese medicines formulae].

    Science.gov (United States)

    Mai, Lan-Yin; Li, Yi-Xuan; Chen, Yong; Xie, Zhen; Li, Jie; Zhong, Ming-Yu

    2014-05-01

    The compatibility of traditional Chinese medicines (TCMs) formulae containing enormous information, is a complex component system. Applications of mathematical statistics methods on the compatibility researches of traditional Chinese medicines formulae have great significance for promoting the modernization of traditional Chinese medicines and improving clinical efficacies and optimizations of formulae. As a tool for quantitative analysis, data inference and exploring inherent rules of substances, the mathematical statistics method can be used to reveal the working mechanisms of the compatibility of traditional Chinese medicines formulae in qualitatively and quantitatively. By reviewing studies based on the applications of mathematical statistics methods, this paper were summarized from perspective of dosages optimization, efficacies and changes of chemical components as well as the rules of incompatibility and contraindication of formulae, will provide the references for further studying and revealing the working mechanisms and the connotations of traditional Chinese medicines.

  17. Determining method and conditional factors of electrochemical fingerprint of Chinese traditional medicine

    Institute of Scientific and Technical Information of China (English)

    ZHANG TaiMing; LIANG YiZeng; YUAN Bin; DING Feng; ZHANG YaPeng; WEI ManQiong; CHEN Xu

    2007-01-01

    The thermodynamic systems and kinetic model suitable for the electrochemical token of the component throng in Chinese traditional medicines have been analyzed.It has been indicated that the damp oscillatory reactions in the non-equilibrium close system and open system without the supplement of dissipative substance have important significance for the throng token and analysis of chemical components in Chinese traditional medicines.Various factors influencing the electrochemical fingerprint, such as reactant species and their concentrations, electrode types, temperature, stir rate, the kind, dosage and granularity of Chinese traditional medicines, have amply been researched by the B-Z oscillatory reaction which used malonic acid as a main dissipative substance.In addition, the quantitative information about the chemical components in Chinese traditional medicines has been discussed in detail.The method and its conditions for determining the electrochemical fingerprint used in scientifically distinguishing and evaluating Chinese traditional medicines have successfully been put forward.

  18. Study on Analgesic Effect of Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    YU Shan; XU Ling; WEI Pin-kang; QIN Zhi-feng; LI Jun; PENG Hai-dong

    2008-01-01

    Chinese medicine has been used in treating pain for a long time.Much progress has been made in studies on the mechanism of the analgesic effect of Chinese medicine in animal experiments.It is found that the analgesic action may be related to the following actions:(1)Reducing the secretion of peripheral algogenic substances and inducing the secretion of pain-sensitive substances;(2)Alleviating the accumulation of local algogenic substances;(3)Increasing the release of endogenous analgesic substances;(4)Regulating c-fos gene and increasing the secretion of such substances in the central newous system,etc.In this paper,the experimental methods and analgesic effect of Chinese medicines are reviewed.

  19. Traditional Chinese Medicine and Constitutional Medicine in China, Japan and Korea: A Comparative Study.

    Science.gov (United States)

    Yu, Wenjun; Ma, Mingyue; Chen, Xuemei; Min, Jiayu; Li, Lingru; Zheng, Yanfei; Li, Yingshuai; Wang, Ji; Wang, Qi

    2017-01-01

    Traditional Chinese medicine (TCM), Japanese-Chinese medicine, and Korean Sasang constitutional medicine have common origins. However, the constitutional medicines of China, Japan, and Korea differ because of the influence of geographical culture, social environment, national practices, and other factors. This paper aimed to compare the constitutional medicines of China, Japan, and Korea in terms of theoretical origin, constitutional classification, constitution and pathogenesis, clinical applications and basic studies that were conducted. The constitutional theories of the three countries are all derived from the Canon of Internal Medicine or Treatise on Febrile and Miscellaneous Diseases of Ancient China. However, the three countries have different constitutional classifications and criteria. Medical sciences in the three countries focus on the clinical applications of constitutional theory. They all agree that different pathogenic laws that guide the treatment of diseases govern different constitutions; thus, patients with different constitutions are treated differently. The three countries also differ in terms of drug formulations and medication. Japanese medicine is prescribed only based on constitution. Korean medicine is based on treatment, in which drugs cannot be mixed. TCM synthesize the treatment model of constitution differentiation, disease differentiation and syndrome differentiation with the treatment thought of treating disease according to three categories of etiologic factors, which reflect the constitution as the characteristic of individual precision treatment. In conclusion, constitutional medicines of China, Japan, and Korea have the same theoretical origin, but differ in constitutional classification, clinical application of constitutional theory on the treatment of diseases, drug formulations and medication.

  20. Treatment of Rheumatoid Arthritis with Traditional Chinese Medicine

    Directory of Open Access Journals (Sweden)

    Wen-Yuan Lee

    2014-01-01

    Full Text Available Rheumatoid arthritis (RA is a chronic inflammatory disease that will affect quality of life and, working efficiency, and produce negative thoughts for patients. Current therapy of RA is treated with disease-modifying antirheumatic drugs (DMARDs. Although most of these treatment methods are effective, most patients still have a pleasant experience either due to poor efficacy or side effects or both. Interleukin-6 receptor (IL6R is important in the pathogenesis of RA. In this study, we would like to detect the potential candidates which inhibit IL6R against RA from traditional Chinese medicine (TCM. We use TCM compounds from the TCM Database@Taiwan for virtually screening the potential IL6R inhibitors. The TCM candidate compound, calycosin, has potent binding affinity with IL6R protein. The molecular dynamics simulation was employed to validate the stability of interaction in the protein complex with calycosin. The analysis indicates that protein complex with calycosin is more stable. In addition, calycosin is known to be one of the components of Angelica sinensis, which has been indicated to have an important role in the treatment of rheumatoid arthritis. Therefore, calycosin is a potential candidate as lead compounds for further study in drug development process with IL6R protein against rheumatoid arthritis.

  1. Traditional Chinese medicine in diagnosis and treatment of fibromyalgia syndrome.

    Science.gov (United States)

    Aliyev, R; Vieth, T; Geiger, G

    2010-11-01

    Fibromyalgia Syndrome (FS) is known for the difficulties arising from classification. The accompanying pain in skeletal muscles, myofascial peri-articular structures and a number of polymorphic symptoms cannot be separated into complexes of symptoms. The application of principles of Traditional Chinese Medicine (TCM) helps in analyzing the symptoms of FS to detect a leading syndrome and thereby establish an individual therapy. Medical histories and objective examinations of 25 patients with FS and 22 patients with vertebrogenic pain syndromes were analyzed according to TCM. A questionnaire was used to determine the leading constitutional type according to the 5-elements-theory. Analyses of the results showed that 83% of patients with FS were of constitutional type of the element earth. The following syndromes were found to be important in FS: 1) liver-Qi-stagnation, 2) Yin and blood deficiency of the liver, 3) Yang-weakness of the spleen and kidney, 4) Yin-weakness of the kidney. Applying TCM for FS allows for separating a group of symptoms and thus individual therapy. The determination of the constitutional type according to the 5-elements-theory may be used for a better understanding of the disharmony pattern.

  2. Progresses in Applications of Stable Isotope Technology to Determining Geographical Origins of Traditional Chinese Medicines

    Directory of Open Access Journals (Sweden)

    WANG Li-ming

    2015-11-01

    Full Text Available Identification of proper geographical origin of traditional Chinese medicine is critical for guaranteeing the quality and efficacy of the medicine, safeguarding the market order, and reducing the medical negligence rate due to fake products. Stable isotope technology, as one of the most efficient methods to determine agricultural products authenticity and traceability, have great advantages and theoretical basis for determining geo-origin of traditional Chinese medicine, and it has been applied to many expensive herbs. In this review, the basic principles of isotopic traceability were firstly introduced. We then elaborate in details the frequently-used isotopic indicators in the geo origin studies of traditional Chinese medicine. We also provide a summary of current research progresses and point out some directions for future research. The purpose of this paper is to promote the applications of stable isotopes to traditional Chinese medicine traceability studies and the establishment of the isotopic database and the improvement of the medicine traceability.

  3. Integrative Medicine in Clinical Practice:From Pattern Differentiation in Traditional Chinese Medicine to Disease Treatment

    Institute of Scientific and Technical Information of China (English)

    吕爱平; 陈可冀

    2009-01-01

    Pattern(syndrome) differentiation is the key theory in traditional Chinese medicine(TCM) and the important diagnostic principle for TCM therapy.More and more medical researchers recognize that the combination of disease diagnosis in biomedicine and pattern differentiation in TCM is essential for the clinical practice, and it has been a common practice model in China since it will produce better clinical effects.

  4. Knowledge sharing in Chinese hospitals identifying sharing barriers in traditional Chinese and Western medicine collaboration

    CERN Document Server

    Zhou, Lihong

    2015-01-01

    This book aims to identify, understand and qualify barriers to the patient-centred knowledge sharing (KS) in interprofessional practice of Traditional Chinese Medicine (TCM) and Western Medicine (WM) healthcare professionals in Chinese hospitals.  This collaboration is particularly crucial and unique to China since, contrary to Western practice, these two types of professionals actually work together complimentary in the same hospital. This study adopted a Grounded Theory approach as the overarching methodology to guide the analysis of the data collected in a single case-study design.  A public hospital in central China was selected as the case-study site, at which 49 informants were interviewed by using semi-structured and evolving interview scripts.  The research findings point to five categories of KS barriers: contextual influences, hospital management, philosophical divergence, Chinese healthcare education and interprofessional training.  Further conceptualising the research findings, it is identifie...

  5. [Characteristics of the development of traditional Chinese medicine in Hong Kong in 20 century].

    Science.gov (United States)

    Zheng, Hong; Luo, Qian

    2013-09-01

    The majority of Hong Kong people are Chinese. They have trusted and relied on traditional Chinese medicine for a long time. For over a century, the professional medical workers, by making use of the regulations set up by the British Hongkong Government to achieve their survival, actively supported inland campaign to fight against the "proposition of abolishing Chinese medicine" and closely cooperated with them for medical education. Together with the immigration of inland Chinese physicians to HK, the HK Government, to maintain the public health, allowed the opening of the first traditional Chinese medicine hospital, and explore the cooperation of Chinese and western medicine. Moreover, funded by the community, the HK TCM hospital paid more attention to charitable service, forming a solid foundation in the masses. These characteristics form a good foundation for the implementation of the Hong Kong Chinese medical policy after Hong Kong's reunion with its motherland.

  6. Inhibition of Urogenital Chlamydia Trachomatis in Vitro by 12 Diuretic Traditional Chinese Medicines

    Institute of Scientific and Technical Information of China (English)

    LI Jianjun(李建军); TU Yuying(涂裕英); TONG Juzhen(佟菊贞); WANG Peitu(汪培土)

    2002-01-01

    Objective:To detect the inhibition of urogenital chlamydia trachomatis (CT) by 12 traditional Chinese medicines in vitro.Methods: The inhibition of CT isolates by these medicines was detected by micro-culture technique with McCoy cells in vitro.Results: All the diuretic traditional Chinese medicines inhibited urogenital CT. The minimum inhibitory concentrations (MICs) ranged from 0.122 mg ml-1 to 62.5 mg ml-1. Diathus superbus L., Poria cocos (Shcw.) Woft,Polyporus umbellatus (Pets.) Fries, and Artemisia capillaries Thunb showed stronger inhibition than the other eight traditional Chinese medicines. The numbers and sizes of inclusions bodies reduced gradually and disappeared finally with the increase of the concentrations.Conclusion: All the 12 diuretic traditional Chinese medicines inhibited urogenital CT.

  7. Progress in Traditional Chinese and Western Medicine Treatments and Nursing Care of Knee Osteoarthritis

    Institute of Scientific and Technical Information of China (English)

    Xiao-Hua Shen; Yi Cui

    2015-01-01

    This paper reviews the causes of knee osteoarthritis, traditional Chinese and Western medicine therapies and nursing research progress and indicates that traditional Chinese and Western medicine have gradually recognized the cause of knee osteoarthritis. Knee osteoarthritis has been treated with various treatments and nursing care planning, and the combination of traditional Chinese and Western medicine has constantly been improved. Nurses should instruct the discharged patient to correctly treat their disease, adopt the health education, and, via the establishment of a healthy lif-estyle, insist on a functional exercise to relieve the pain, delay disease progression, and improve quality of life.

  8. [Process and key points of clinical literature evaluation of post-marketing traditional Chinese medicine].

    Science.gov (United States)

    Liu, Huan; Xie, Yanming

    2011-10-01

    The clinical literature evaluation of the post-marketing traditional Chinese medicine is a comprehensive evaluation by the comprehensive gain, analysis of the drug, literature of drug efficacy, safety, economy, based on the literature evidence and is part of the evaluation of evidence-based medicine. The literature evaluation in the post-marketing Chinese medicine clinical evaluation is in the foundation and the key position. Through the literature evaluation, it can fully grasp the information, grasp listed drug variety of traditional Chinese medicines second development orientation, make clear further clinical indications, perfect the medicines, etc. This paper discusses the main steps and emphasis of the clinical literature evaluation. Emphasizing security literature evaluation should attach importance to the security of a comprehensive collection drug information. Safety assessment should notice traditional Chinese medicine validity evaluation in improving syndrome, improveing the living quality of patients with special advantage. The economics literature evaluation should pay attention to reliability, sensitivity and practicability of the conclusion.

  9. non-drug therapy of traditional Chinese medicine treatment of knee osteoarthritis

    Institute of Scientific and Technical Information of China (English)

    Dong-Mei Li; Pin-Jie Gu; Lei Yin

    2016-01-01

    To review combining manipulation in recent years and the progress of moxibustion treatment of knee osteoarthritis, to evaluate the research progress of Chinese medicine external treatment knee osteoarthritis. Collect and analyze non-drug therapy of traditional Chinese medicine for the treatment of knee osteoarthritis of data in recent years. Chinese medicine external treatment can significantly improve the stability of the knee joint, patients walking ability, and quality of life of patients. Chinese medicine non-drug therapy can be used as ideal scheme for the treatment of knee osteoarthritis.

  10. Towards Semantic e-Science for Traditional Chinese Medicine

    Directory of Open Access Journals (Sweden)

    Zhou Chunying

    2007-05-01

    Full Text Available Abstract Background Recent advances in Web and information technologies with the increasing decentralization of organizational structures have resulted in massive amounts of information resources and domain-specific services in Traditional Chinese Medicine. The massive volume and diversity of information and services available have made it difficult to achieve seamless and interoperable e-Science for knowledge-intensive disciplines like TCM. Therefore, information integration and service coordination are two major challenges in e-Science for TCM. We still lack sophisticated approaches to integrate scientific data and services for TCM e-Science. Results We present a comprehensive approach to build dynamic and extendable e-Science applications for knowledge-intensive disciplines like TCM based on semantic and knowledge-based techniques. The semantic e-Science infrastructure for TCM supports large-scale database integration and service coordination in a virtual organization. We use domain ontologies to integrate TCM database resources and services in a semantic cyberspace and deliver a semantically superior experience including browsing, searching, querying and knowledge discovering to users. We have developed a collection of semantic-based toolkits to facilitate TCM scientists and researchers in information sharing and collaborative research. Conclusion Semantic and knowledge-based techniques are suitable to knowledge-intensive disciplines like TCM. It's possible to build on-demand e-Science system for TCM based on existing semantic and knowledge-based techniques. The presented approach in the paper integrates heterogeneous distributed TCM databases and services, and provides scientists with semantically superior experience to support collaborative research in TCM discipline.

  11. Opening up a Way of Evaluating Evidence-based Medicine in Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Evidence-based medicine is an authoritative way of evaluating the clinical efficacy of drugs, which provides the direct evidence for clinical medication. The rise of evidence-based medical research brought about the changes in Chinese medicine from the empirical medical era into the era of evidence-based medicine. Chinese medicine, as the experience

  12. Principle, traits and functions of electrochemical fingerprint of Chinese traditional medicine

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    In regard to such challenging analysis problems as scientific identification and quality evaluation of Chinese traditional medicine, the electrochemical fingerprint technique of Chinese traditional medicine has been researched. The principle, traits, functions, etc., of the electrochemical fingerprint have detailedly been analyzed and discussed by the B-Z oscillatory system using malonic acid as main dissipation substance, characterized by the fact that different influences of different Chinese traditional medicines on the mechanism of the oscillatory reaction cause different changes of the shape of the potential-time curve of the oscillatory system under the conditions of constant temperature and pressure. An economical, simple and convenient, easy pushing and effective scientific method for distinguishing and evaluating multifarious Chinese traditional medicines has successfully been put forward.

  13. Thirty-five Infantile Purpura Nephritis Patients Treated with Integrated Traditional Chinese and Western Medicine

    Institute of Scientific and Technical Information of China (English)

    ZHENG; Tian-wen

    2001-01-01

    Thirty-five patients of infantile purpura nephritis (IPN) were treated with integrated traditional Chinese and western medicine (TCM-WM) from January 1994 to December 1998, with good efficacy obtained, and following is the report.

  14. Safety concerns of herbal products and traditional Chinese herbal medicines: Dehydropyrrolizidine alkaloids and aristolochic acid

    Science.gov (United States)

    In many countries, including the United States, herbal supplements, tisanes and vegetable products, including traditional Chinese medicines, are largely unregulated and their content is not registered, monitored or verified. Consequently, potent plant toxins including dehydropyrrolizidine alkaloids ...

  15. [Opportunity and challenge of post-marketing evaluation of traditional Chinese medicine].

    Science.gov (United States)

    Du, Xiao-Xi; Song, Hai-Bo; Ren, Jing-Tian; Yang, Le; Guo, Xiao-Xin; Pang, Yu

    2014-09-01

    Post-marketing evaluation is a process which evaluate the risks and benefits of drug clinical application comprehensively and systematically, scientific and systematic results of post-marketing evaluation not only can provide data support for clinical application of traditional Chinese medicine, but also can be a reliable basis for the supervision department to develop risk control measures. With the increasing demands for treatment and prevention of disease, traditional Chinese medicine has been widely used, and security issues are also exposed. How to find risk signal of traditional Chinese medicine in the early stages, carry out targeted evaluation work and control risk timely have become challenges in the development of traditional Chinese medicine industry.

  16. Safety concerns of herbal products and traditional Chinese herbal medicines: Dehydopyrrolizidine alkaloids and aristolochic acid

    Science.gov (United States)

    In many countries, including the United States, herbal supplements, tisanes and vegetable products including traditional Chinese medicines are largely unregulated and their content is not registered, monitored or verified. Consequently potent plant toxins including dehydopyrrolizidine alkaloids and...

  17. Recent Studies on the Molecular Mechanism of Treatment of Liver Diseases by Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    聂广

    2002-01-01

    @@ Lots of achievements were obtained in studying on mechanism of treatment for various liver diseases by traditional Chinese medicine (TCM) since the developing of molecular biological technique. It is introduced as follows.

  18. Screening test for anti-Helicobacter pylori activity of traditional Chinese herbal medicines

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    AIM:To evaluate the anti-Helicobacter pylori (H.pylori) activity of 50 traditional Chinese herbal medicines in order to provide the primary evidence for their use in clinical practice.METHODS:A susceptibility test of water extract from 50 selected traditional Chinese herbal medicines for in vitro H.pylori Sydney strain 1 was performed with broth dilution method.Anti-H.pylori activity of the selected Chinese herbal medicines was evaluated according to their minimum inhibitory concentration (MIC).RESULTS:The ...

  19. The mechanisms in treatment of acute pancreatitis by traditional Chinese medicine

    Institute of Scientific and Technical Information of China (English)

    Xiping Zhang; Ying Wang; Yan Shi

    2006-01-01

    As common acute abdomen, most of acute pancreatitis(AP) are self-restricted. Only a few patients may develop into worse state with local complications or organ failures, and finally neastic acute pancreatitis (NAP). With the change of people's dietaries, cholelithiasis morbidity and popularization of wine in recent years, the number of AP patients has increased.Although people conducted enormous studies on pathogenesis of AP and brought forward many be valuable theories, yet the exact mechanism is still unclear by far. There are many therapies of AP which should be unexceptionally classified as operative therapy and non-operative therapy. With the increasing understanding of the disease in recent years, we found many defects of operation and good therapeutic effects of traditional Chinese medicine in AP. Traditional Chinese medicine as an auxiliary therapy has been generally paid close attention in clinical practices. Traditional Chinese medicine is a treasure-house of China. This article summarizes the main mechanisms of AP treatment by traditional Chinese medicine and the progress of laboratory studies. It aims to help people recognize the multiple-target treatment effects and conspicuous efficacy of traditional Chinese medicine and promote the popularization of traditional Chinese medicine in AP treatment.

  20. Applications of HPLC/MS in the analysis of traditional Chinese medicines%Applications of HPLC/MS in the analysis of traditional Chinese medicines

    Institute of Scientific and Technical Information of China (English)

    Miao Li; Xiao- Fang Hou; Jie Zhang; Si-Cen Wang; Qiang Fu; Lang- Chong He

    2011-01-01

    In China, traditional Chinese medicines (TCMs) have been used in clinical applications for thousands of years. The successful hyphenation of high-performance liquid chromatography (HPLC) and mass spectrometry (MS) has been applied widely in TCMs and biolo

  1. The remote supervisory and controlling experiment system of traditional Chinese medicine production based on Fieldbus

    Science.gov (United States)

    Zhan, Jinliang; Lu, Pei

    2006-11-01

    Since the quality of traditional Chinese medicine products are affected by raw material, machining and many other factors, it is difficult for traditional Chinese medicine production process especially the extracting process to ensure the steady and homogeneous quality. At the same time, there exist some quality control blind spots due to lacking on-line quality detection means. But if infrared spectrum analysis technology was used in traditional Chinese medicine production process on the basis of off-line analysis to real-time detect the quality of semi-manufactured goods and to be assisted by advanced automatic control technique, the steady and homogeneous quality can be obtained. It can be seen that the on-line detection of extracting process plays an important role in the development of Chinese patent medicines industry. In this paper, the design and implement of a traditional Chinese medicine extracting process monitoring experiment system which is based on PROFIBUS-DP field bus, OPC, and Internet technology is introduced. The system integrates intelligence node which gathering data, superior sub-system which achieving figure configuration and remote supervisory, during the process of traditional Chinese medicine production, monitors the temperature parameter, pressure parameter, quality parameter etc. And it can be controlled by the remote nodes in the VPN (Visual Private Network). Experiment and application do have proved that the system can reach the anticipation effect fully, and with the merits of operational stability, real-time, reliable, convenient and simple manipulation and so on.

  2. [Research on our hospital inventory management status quo of traditional Chinese medicine drugs and treatment method].

    Science.gov (United States)

    Zhang, Ying-Nan; Xu, Wen

    2014-03-01

    Under the background of the new medical reform, a large variety of traditional Chinese medicine from complicated sources, Chinese traditional medicine of actor of true and false of the quality directly affect the drug safety and clinical efficacy, but also relate to the social and economic benefits of hospital. Along with the development of the modern management of medical institutions and drug circulation circulation system reform in our country, the hospital drug inventory, supply and management work is an important topic for the pharmaceutical trading. However, there is always contradiction, dispensary need to supple pharmacy, in order to satisfy the demands of hospital patients with normal diagnosis and treatment work. However, if the drug inventory is too much, not only increases the drug monitoring problem, at the same time, but also causes storage costs rise. Therefore, completing scientific and reasonable storage and management becomes urgent problems at present. Wherefore, our country administration of traditional Chinese medicine in 2007 promulgated the "Chinese traditional medicine yinpian management norms in hospital", aims to standardize management of Chinese traditional medicine quality and improve the safety of drugs. The author through looking up information and visiting survey, to understand the currently existing problems, and summarizes the literature inland and abroad in recent years Chinese medicine drug inventory management work experience, in view of status quo of Chinese medicine inventory management in China, put forward the solution. To guarantee TCM pharmacy management more standardized, more standard, to adapt to the new reform of Chinese traditional medicine industry, improve the management level of hospital, defend the hospital's reputation and the patient's interests.

  3. [Analysis on prescription rules of treating senile dementia based on traditional Chinese medicine inheritance auxiliary systems].

    Science.gov (United States)

    Zong, Xin; Ji, Xu-Ming; Wei, Feng-Qin; Shi, Zuo-Rong

    2014-02-01

    This is designed to analyze and summarize medication rules for treating senile dementia with Chinese medicine in CNKI according to the traditional Chinese medicine (TCM) inheritance auxiliary system. Collect documents in CNKI that account treating senile dementia with Chinese formula; filter and establish a formula database, and then to search for medication rules on the TCM inheritance auxiliary system. It is filtered that 104 formulas are used for treating senile dementia screening treat senile dementia, involving 147 kinds of Chinese medicine. Tonic medicine are most frequently used, followed by the medicine of activating blood circulation and resuscitating; medicine pair most used is Ligusticum chuanxiong Hort-Acorus tatarinowii, accounting for 27.9% of all formula. And then 8 core pairs and 4 new formulas are evolved. Analysis on formulas for treating senile dementia filtered form CNKI by TCM inheritance auxiliary system shows prescription is mainly tonifying, activating blood circulation and resuscitating, that reveals prescription rules, to provide a reference for clinical treatment.

  4. [Technical scheme of real-time evaluation of traditional Chinese medicine orally disintegrating tablets].

    Science.gov (United States)

    Qin, Dong; Chen, Xu-dong; Feng, Liang; Gu, Jun-fei; Yuan, Jia-rui; Jia, Xiao-bin

    2014-12-01

    Orally disintegrating tablets (ODT), a kind of new solid tablet that rapidly disintegrates to work in the mouth, has became the hot form of new drug research in recent years with many advantages, such as the convenient taking, a widely applicable people, fast acting, high bioavailability, good compliance, and so on. ODT has been widely used in chemical medicines, while the application of it in traditional Chinese medicines (TCMs) is still in the stage of development The development of TCMs ODT provides a new direction for the research of Chinese medicine new dosage, accelerates the pace of connecting to the world and modernization of Chinese medicine. This dosage has a broad market prospect, and its quality control and assessment standards, taste, the disintegration time in vitro and evaluation method are the key factors that affect the industrialization, standardization of Chinese medicine ODT. Therefore, this paper reviewed the characteristics, preparation, taste masking technology and quality evaluation with new technology of ODT. Meantime, numerous application examples of ODT used in traditional Chinese medicine were described. We expect to provide the reference and utilization for the development of traditional Chinese medicine orally disinteeratine tablets.

  5. Review of the use of botanicals for epilepsy in complementary medical systems--Traditional Chinese Medicine.

    Science.gov (United States)

    Xiao, Fenglai; Yan, Bo; Chen, Lei; Zhou, Dong

    2015-11-01

    In traditional Chinese medicine, botanical remedies have been used for centuries to treat seizures. This review aimed to summarize the botanicals that have been used in traditional Chinese medicine to treat epilepsy. We searched Chinese online databases to determine the botanicals used for epilepsy in traditional Chinese medicine and identified articles using a preset search syntax and inclusion criteria of each botanical in the PubMed database to explore their potential mechanisms. Twenty-three botanicals were identified to treat epilepsy in traditional Chinese medicine. The pharmacological mechanisms of each botanical related to antiepileptic activity, which were mainly examined in animal models, were reviewed. We discuss the use and current trends of botanical treatments in China and highlight the limitations of botanical epilepsy treatments. A substantial number of these types of botanicals would be good candidates for the development of novel AEDs. More rigorous clinical trials of botanicals in traditional Chinese medicine for epilepsy treatment are encouraged in the future. This article is part of a Special Issue entitled "Botanicals for Epilepsy".

  6. Research progress of traditional Chinese medicine treatment of diabeticnephropathy

    Institute of Scientific and Technical Information of China (English)

    Xiaoming Wu; Na Zhang; Yanbin Gao

    2014-01-01

    Diabetic nephropathy is the main reason of the end-stage renal failure and endanger human health seriously.Ef-fective treatment of diabetic nephropathy is in an urgent demand.In recent years,we confirmed the good effect of TCM on dia-betic nephropathy by evidence based medicine method.We also explored the treatment mechanism of TCM on diabetic ne-phropathy from overall level,cellular level and molecular level and found that both single herb and Chinese herbal compound can treat diabetic nephropathy by multiple targets control.TCM may become one of the effective methods for treating diabetic ne-phropathy.This paper will review the advances in this research field of recent years and provide references for future researches.

  7. Efficacy and Safety of Traditional Chinese Medicine for Diabetes: A Double-Blind, Randomised, Controlled Trial

    OpenAIRE

    Linong Ji; Xiaolin Tong; Hongyuan Wang; Haoming Tian; Huimin Zhou; Lili Zhang; Qifu Li; Yizhong Wang; Hongmei Li; Min Liu; Hongjie Yang; Yanbin Gao; Yan Li; Quanmin Li; Xiaohui Guo

    2013-01-01

    BACKGROUND: Treatment of diabetes mellitus with Traditional Chinese Medicine has a long history. The aim of this study is to establish the safety and efficacy of traditional Chinese medicine combined with glibenclamide to treat type 2 diabetes mellitus. METHODS: In a controlled, double blind, multicentre non-inferiority trial, 800 patients with unsatisfactory glycemic control (fasting glucose 7-13 mmol/L and HbA1c 7-11%) were randomly assigned to receive Xiaoke Pill, a compound of Chinese her...

  8. To Set Up a Logistic Regression Prediction Model for Hepatotoxicity of Chinese Herbal Medicines Based on Traditional Chinese Medicine Theory

    Science.gov (United States)

    Liu, Hongjie; Li, Tianhao; Zhan, Sha; Pan, Meilan; Ma, Zhiguo; Li, Chenghua

    2016-01-01

    Aims. To establish a logistic regression (LR) prediction model for hepatotoxicity of Chinese herbal medicines (HMs) based on traditional Chinese medicine (TCM) theory and to provide a statistical basis for predicting hepatotoxicity of HMs. Methods. The correlations of hepatotoxic and nonhepatotoxic Chinese HMs with four properties, five flavors, and channel tropism were analyzed with chi-square test for two-way unordered categorical data. LR prediction model was established and the accuracy of the prediction by this model was evaluated. Results. The hepatotoxic and nonhepatotoxic Chinese HMs were related with four properties (p flavors (p 0.05). There were totally 12 variables from four properties and five flavors for the LR. Four variables, warm and neutral of the four properties and pungent and salty of five flavors, were selected to establish the LR prediction model, with the cutoff value being 0.204. Conclusions. Warm and neutral of the four properties and pungent and salty of five flavors were the variables to affect the hepatotoxicity. Based on such results, the established LR prediction model had some predictive power for hepatotoxicity of Chinese HMs. PMID:27656240

  9. To Set Up a Logistic Regression Prediction Model for Hepatotoxicity of Chinese Herbal Medicines Based on Traditional Chinese Medicine Theory.

    Science.gov (United States)

    Liu, Hongjie; Li, Tianhao; Chen, Lingxiu; Zhan, Sha; Pan, Meilan; Ma, Zhiguo; Li, Chenghua; Zhang, Zhe

    2016-01-01

    Aims. To establish a logistic regression (LR) prediction model for hepatotoxicity of Chinese herbal medicines (HMs) based on traditional Chinese medicine (TCM) theory and to provide a statistical basis for predicting hepatotoxicity of HMs. Methods. The correlations of hepatotoxic and nonhepatotoxic Chinese HMs with four properties, five flavors, and channel tropism were analyzed with chi-square test for two-way unordered categorical data. LR prediction model was established and the accuracy of the prediction by this model was evaluated. Results. The hepatotoxic and nonhepatotoxic Chinese HMs were related with four properties (p 0.05). There were totally 12 variables from four properties and five flavors for the LR. Four variables, warm and neutral of the four properties and pungent and salty of five flavors, were selected to establish the LR prediction model, with the cutoff value being 0.204. Conclusions. Warm and neutral of the four properties and pungent and salty of five flavors were the variables to affect the hepatotoxicity. Based on such results, the established LR prediction model had some predictive power for hepatotoxicity of Chinese HMs.

  10. Comparison on Temperament Theory between Traditional Chinese Medicine and Modern Psychology

    Institute of Scientific and Technical Information of China (English)

    SHI Le

    2002-01-01

    This study has explained and compared temperament theory between traditional Chinese medicine and modernrn psychology on five aspects of concept, characteristics, classification, influential factors and practical significance. And we thought that this study had guiding effect on clinical practice under the new medicine model.

  11. Current influences on traditional Chinese medicine education in the UK: the experience of a collaborative programme between Middlesex University and Beijing University of chinese medicine.

    OpenAIRE

    Bell, Celia M.; Cheng, Ming Zhao

    2005-01-01

    A long and successful collaboration has existed between Middlesex University and Beijing University of Chinese Medicine in the delivery of high quality education and practitioner training in Traditional Chinese Medicine (TCM) in the UK. A joint degree programme was validated by the two Universities in 1997 offering integrated training at undergraduate level in both Chinese Herbal Medicine and Acupuncture & Moxibustion. This programme was the first of its kind to be offered in Europe by a pu...

  12. Traditional Chinese Medicine, Food Therapy, and Hypertension Control: A Narrative Review of Chinese Literature.

    Science.gov (United States)

    Zou, Ping

    2016-01-01

    Despite the lack of English literature about Traditional Chinese Medicine (TCM) food therapy, there is abundant Chinese literature about the application of food therapy for hypertension control. This paper summarizes basic concepts of TCM, the principles of food therapy and its application for hypertension control according to Chinese literature. In TCM, food is conceptualized according to both nutritional and functional aspects, and can be used to treat illnesses. Four principles of TCM food therapy including light eating, balancing the "hot" and "cold" nature of food, the harmony of the five flavors of food, and consistency between dietary intake and different health conditions, can be used to facilitate hypertension control. Based on a statistical analysis of antihypertensive foods recommended in 20 books on the application of food therapy for hypertension control, the 38 most frequently recommended are celery, tomato, banana, hawthorn, garlic, onion, seaweed, apple, corn, green beans, persimmon, laver, kiwi, watermelon, eggplant, carrots, mushroom, peanut, soy products, sea cucumber, buckwheat, garland chrysanthemum, spinach, honey, dairy products, vinegar, black fungus, jellyfish, green onion, shepherd's purse, soybean, potato, pear, winter melon, bitter melon, oat, pea, and tea. Food therapy emphasizes the therapeutic effects of food, considering its nature, taste, and function on human balanced health, which leads to optimal blood pressure control. Current literature suggests that food therapy is effective in blood pressure control and can be incorporated into blood pressure self-management in the Chinese population.

  13. [Construction and thinking of data element standard directory of traditional Chinese medicine clinical pharmacy information].

    Science.gov (United States)

    Wang, Xiao-Xia; Jin, Zhong-Zheng; Guo, Gui-Ming; Zhai, Hua-Qiang; Jin, Shi-Yuan

    2014-05-01

    The aim of this study was to develop the data element standard directory of traditional Chinese medicine (TCM) clinical pharmacy information, to provide application standards and models of TCM clinical pharmacy for the electronic medical record (EMR). The developed line of work is as follows: initially establish research through four forms: literature analysis, questionnaires, discussion groups, expert advice. The research range from the Chinese herbal medicine research, herbal origin, harvesting, processing, identification of traits, physical and chemical identification, modern research, character, taste, Indications, clinical application, processing, dispensing medicine, Chinese medicine specifications, usage, dosage, caution, efficacy indications to small packaging applications, drug research, management and other related issues, including traditional Chinese medicine theory, application and hospital management information; according to the general and part 16 content of the national "Health Information Data Element Standards", and the basic method of extracting data element to study and develop the data element of TCM clinical pharmacy information from the defining content. Correspondingly propose the ideas and methods of construction of the "Data Element Standard Directory of TCM Clinical Pharmacy Information", sort out medicine clinical information data element standard catalog, divided into basic categories, clinical application class, management class three parts, and set norms and standards of identifying data elements, definitions, allowable value of traditional Chinese medicine clinical information, and discuss the sources and standards of information collection, leaving the interface, standardized and scientific terminology, docking with the existing standards, maintenance and management program and oter issues.

  14. Dendritic Cells as a Pharmacological Target of Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    Xin Chen; Lu Yang; O. M. Zack Howard; Joost J. Oppenheim

    2006-01-01

    Dendritic cells (DCs) represent a heterogeneous population of professional antigen-presenting cells (APCs) that play a central role in the initiation and regulation of immune responses. There is considerable evidence that DCs can be used as therapeutic targets for pharmacological modulation of immune responses. Traditional Chines emedicine (TCM) has a long-standing history of using herbal medicine in the treatment of variety of human diseases.Many of the clinical effects of TCM have reportedly been attributed to the up- or down-regulation of immune responses. Accumulating evidence indicates that TCM and its components can interfere with immune responses at the earliest stage by targeting key functions of DCs. Here, we review those published studies of TCM with respect to their effects on immunobiological functions of DCs. Investigations based on both chemical entities derived from TCM as well as TCM herbal mixtures are presented. These studies suggest that various TCM herbal medicines have the capacity to inhibit or promote major functions of DCs, such as differentiation, maturation, cytokine production, survival, antigen uptake and presentation as well as trafficking. These studies have revealed novel biological effects of TCM and documented the utility of this approach to discover novel biological modifier of DC functions derived from natural sources.

  15. [Effect and mechanism of traditional Chinese medicine and their active constituents in postmenopausal osteoporosis].

    Science.gov (United States)

    Zhao, Piwen; Niu, Jianzhao; David, Yue-Wei Lee; Wang, Jifeng; Sun, Yanling; Li, Yadong

    2012-06-01

    Postmenopausal osteoporosis is one of the commonest systemic bone metabolism diseases among menopausal women, mainly caused by lowering internal estrogen. Although Hormone Replacement Therapy (HRT) is an effective method in clinical practice for years, it shows side-effect in increasing gynecological carcinoma. It has already been proved by clinical tests that multiple traditional Chinese medicine formulas and their monomer ingredients and phytoestrogen-like active constituents contained in traditional Chinese medicines are effective on treating osteoporosis with relatively less side-effects comparing with HRT. They show protective and therapeutic effects by acting on estrogen receptors of targeted tissues and targeted cells and then affecting expressions of bone metabolism-related regulatory proteins and factors in downstream signal conduct paths. Recent studies on estrogen related receptor (ERR) provide new possibilities and pathways for mechanism of traditional Chinese medicine and their active constituents in osteoporosis.

  16. Mining Compatibility Rules from Irregular Chinese Traditional Medicine Database by Apriori Agorithm

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    This paper aims to mine the knowledge and rules on compatibility of drugs from the prescriptions for curing arrhythmia in the Chinese traditional medicine database by Apriori algorithm. For data preparation, 1 113 prescriptions for arrhythmia, including 535herbs (totally 10884 counts of herbs) were collected into the database. The prescription data were preprocessed through redundancy reduction, normalized storage, and knowledge induction according to the pretreatment demands of data mining. Then the Apriori algorithm was used to analyze the data and form the related technical rules and treatment procedures. The experimental result of compatibility of drugs for curing arrhythmia from the Chinese traditional medicine database shows that the prescription compatibility obtained by Apriori algorithm generally accords with the basic law of traditional Chinese medicine for arrhythmia. Some special compatibilities unreported were also discovered in the experiment, which may be used as the basis for developing new prescriptions for arrhythmia.

  17. Two-dimensional liquid chromatography and its application in traditional Chinese medicine analysis and metabonomic investigation.

    Science.gov (United States)

    Li, Zheng; Chen, Kai; Guo, Meng-zhe; Tang, Dao-quan

    2016-01-01

    Two-dimensional liquid chromatography has become an attractive analytical tool for the separation of complex samples due to its enhanced selectivity, peak capacity, and resolution compared with one-dimensional liquid chromatography. Recently, more attention has been drawn on the application of this separation technique in studies concerning traditional Chinese medicines, metabonomes, proteomes, and other complex mixtures. In this review, we aim to examine the application of two-dimensional liquid chromatography in traditional Chinese medicine analysis and metabonomic investigation. The classification and evaluation indexes were first introduced. Then, various switching methods were summarized when used in an on-line two-dimensional liquid chromatography system. Finally, the applications of this separation technique in traditional Chinese medicine analysis and metabonomic investigation were discussed on the basis of specific studies.

  18. [Progress and prospects of research on information processing techniques for intelligent diagnosis of traditional Chinese medicine].

    Science.gov (United States)

    Zhou, Chang-Le; Zhang, Zhi-Feng

    2006-11-01

    Information processing for intelligent diagnosis of traditional Chinese medicine (TCM), an important part of the modernization of Chinese medicine, attracts world wide attention from the science circle. This article presents a systematic introduction to the development of information technology, especially the processing of pulse and tongue images and systems of computer-aided Chinese medical diagnosis. Furthermore, it points out four essential areas of future research, including epistemic logic system of syndrome differentiation, system construction technology, data miming technology and information acquisition and analysis in TCM diagnosis.

  19. History and Experience: A Survey of Traditional Chinese Medicine Treatment for Alzheimer's Disease

    Directory of Open Access Journals (Sweden)

    Ping Liu

    2014-01-01

    Full Text Available Traditional Chinese medicine (TCM is practiced in the Chinese health care system for more than 2,000 years. In recent years, herbal medicines, which are used to treat Alzheimer's disease (AD in China based on TCM or modern pharmacological theories have attracted considerable attention. In this paper, we discuss etiology and pathogenesis of AD, TCM therapy, and herbal extracts for the treatment of AD. There is evidence to suggest that TCM therapy may offer certain complementary cognitive benefits for the treatment of AD. Chinese herb may have advantages with multiple target regulation compared with the single-target antagonist in view of TCM.

  20. Hypertension knowledge in urban elderly patients: comparison between adherents to traditional Chinese medicine and Western medicine

    Institute of Scientific and Technical Information of China (English)

    Jiangping Lin; Huining Lei; Fang Liu

    2008-01-01

    Objective To compare knowledge about hypertension between elderly Chinese urban patients with preferences for either traditional Chinese medicine (TCM) or Western medicine (WM).Methods Elderly (≥ 65 years old) patients with hypertension who prefer TCM treatment (n=112) or WM (n=126) were questioned about hypertension.Their answers were compared.Results Only 32.6% of participants correctly identified hypertension as a main risk factor of coronary heart disease and stroke,22.3% of patients answered that the main purpose of hypertension control was preventing cardiovascular disease.Other major reasons for these patients to seek medical treatment for their hypertension included:persuasion by physicians or their family members (21.6%),alleviating symptoms such as headache and dizziness (16.8%),lowering blood pressure without knowing specific reason (12.4%).The predictors for poor knowledge of hypertension were similar irrespective of preference for WM or TCM treatment,and included those with lower levels of education and older age.Television and newspaper (46.8%) were the most frequent sources of hypertension information for both groups.Among those who preferred TCM treatment,"TCM has fewer side effects than WM" and "TCM cures disease while WM only alleviates symptoms" were common beliefs held.Conclusion This study shows that knowledge of hypertension is similar among Chinese urban patients with preferences for either WM or TCM treatment and that misunderstandings about hypertension are common among the elderly patients.In order to control hypertension effectively,public health education is necessary.This should target those with a lower level of education and older age.

  1. Genetic authentication of ginsengand other traditional Chinese medicine

    Institute of Scientific and Technical Information of China (English)

    CCHON; YCCHOW; FYZENG; FCCLEUNG

    2003-01-01

    The main objective of this paper is to review the chemical and genetic methods used in authentication ofginseng, especially the recent advances in microsatellite genotyping and its application to the authentication of othertraditional Chinese medicines (TCM). The standardization and modernization of TCM hinge on the authenticationof their botanical identities. Analysis of well-characterized marker compounds is now the most popular method foridentifying the herbal materials and quality control of TCM, eg, ginsenoside profiling for authentication of Panaxspecies. However, in many herbal species the chemical composition of the plant changes with the external environment and processing conditions, which lowers the reliability of these authentication methods. In the light of theadvances in molecular biotechnology in the past few decades, genetic tools are now considered to provide morestandardized and reliable methods for authentication of herbal materials at the DNA level. These genetic toolsinclude random amplified polymorphic DNA (RAPD), DNA fingerprinting using multi-loci probes, restriction fragment length polymorphism (RFLP), amplified fragment length polymorphism (AFLP), and microsatellite markertechnology. The practicality of these methods varies in terms of their sensitivity, reliability, reproducibility, andrunning cost. Using ginseng as an example, we reviewed the advantages and limitations of these molecular tech-niques in TCM authentication. We have developed a set of microsatellite markers from American ginseng that areable to differentiate Panax ginseng and Panax quinquetolius with the resolution down to farm level, ie, confirmationof its botanical identity and origin. Compared with other molecular techniques, microsatellite marker technology ismore robust, accurate, reproducible, reliable, and sensitive. This is essential for large-scale TCM authenticationcenters.

  2. Thinking and practice of accelerating transformation of traditional Chinese medicine from experience medicine to evidence-based medicine.

    Science.gov (United States)

    Liu, Baoyan; Zhang, Yanhong; Hu, Jingqing; He, Liyun; Zhou, Xuezhong

    2011-06-01

    The gradual development of Chinese medicine is based on constant accumulation and summary of experience in clinical practice, but without the benefit of undergoing the experimental medicine stage. Although Chinese medicine has formed a systematic and unique theory system through thousands of years, with the development of evidence-based medicine, the bondage of the research methods of experience medicine to Chinese medicine is appearing. The rapid transition and transformation from experience medicine to evidence-based medicine have become important content in the development of Chinese medicine. According to the features of Chinese medicine, we propose the research idea of "taking two ways simultaneously," which is the study both in the ideal condition and in the real world. Analyzing and constructing the theoretical basis and methodology of clinical research in the real world, and building the stage for research technique is key to the effective clinical research of Chinese medicine. Only by gradually maturing and completing the clinical research methods of the real world could we realize "taking two ways simultaneously" and complementing each other, continuously produce scientific and reliable evidence of Chinese medicine, as well as transform and develop Chinese medicine from experience medicine to evidence-based medicine.

  3. Traditional Chinese medicine valuably augments therapeutic options in the treatment of climacteric syndrome.

    Science.gov (United States)

    Eisenhardt, Sarah; Fleckenstein, Johannes

    2016-07-01

    Climacteric syndrome refers to recurring symptoms such as hot flashes, chills, headache, irritability and depression. This is usually experienced by menopausal women and can be related to a hormonal reorganization in the hypothalamic-pituitary-gonadal axis. In Traditional Chinese Medicine, originating 1000s of years ago, above-mentioned symptoms can be interpreted on the basis of the philosophic diagnostic concepts, such as the imbalance of Yin and Yang, the Zang-Fu and Basic substances (e.g. Qi, Blood and Essence). These concepts postulate balance and harmonization as the principle aim of a treatment. In this context, it is not astounding that one of the most prominent ancient textbooks dating back to 500-200 BC, Huang di Neijing: The Yellow Emperor's Classic of Internal Medicine gives already first instructions for diagnosis and therapy of climacteric symptoms. For therapy, traditional Chinese medicine comprises five treatment principles: Chinese herbal medicine, TuiNa (a Chinese form of manual therapy), nutrition, activity (e.g. QiGong) and acupuncture (being the most widespread form of treatment used in Europe). This review provides an easy access to the concepts of traditional Chinese medicine particularly regarding to climacteric syndrome and also focuses on current scientific evidence.

  4. The Impact of a Cultural Immersion Study Abroad Experience in Traditional Chinese Medicine.

    Science.gov (United States)

    Conroy, Shelley F; Taggart, Helen M

    2016-09-01

    Study abroad programs have increased dramatically. Most programs are short-term and include a cultural immersion as well as classroom and/or service learning. In this article, the authors discuss a study abroad program to China that included cultural immersion and classroom learning specific to traditional Chinese medicine. Participants kept journals with specific writing assignments and reflections about their experiences during the trip. At the conclusion of the trip, a qualitative survey was administered to the participants. Outcomes included the benefits of cultural immersion and a greater appreciation of cultural diversity, complementary and alternative medicine and holistic health care. Participants were able to describe transformational experiences of living in and learning from the Chinese culture and peoples. They intended to incorporate their experiences and enhanced understanding of traditional Chinese medicine and complementary and alternative therapies to provide culturally competent holistic health care in their nursing practice.

  5. General Survey of Traditional Chinese Medicine and Western Medicine Researches on Tumor Metastasis

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Metastasis and recurrence of tumors is the chief cause of death for such patients. Therefore,researches on the mechanism of its metastasis, prevention and treatment are the focal points in the field of traditional Chinese medicine (TCM) and Western medicine (WM) at present. WM practitioners' study on tumor metastasis involved its occurrence and development including every detail and process, and now it even has developed into the molecular biological field. In treatment surgical operation and radio- chemotherapy is used as the main means, but the efficacy is not too optimistic. In recent years, TCM, as part of the comprehensive therapy, has been gradually gaining attention of oncologists. Aimed at solving the difficult problems in metastasis of tumor, many TCM practitioners on the basis of syndrome differentiation have raised theories about the cause of tumor metastasis. On the basis of these theories, some TCM recipes against tumor metastasis have been developed to serve as an effective supplement to surgical operation, radio- and chemotherapy. The present article summarizes research results in recent years about the cause of formation of tumor and its metastasis by TCM and WM, so as to offer some theoretical clues to the study of tumors metastasis.

  6. Current Status and Future Perspective in the Globalization of Traditional Chinese Medicines

    Directory of Open Access Journals (Sweden)

    Wan-Ying Wu

    2015-01-01

    Full Text Available Globalization of traditional Chinese medicines started around 1996, which was initiated by the Chinese government. However, substantial progress was only achieved in recent years including the adoption of TCM quality monographs in the western pharmacopoeias (United States Pharmacopoeia and European Pharmacopoeia and registration in main stream drug regulatory agencies such as US Food and Drug Administration (FDA and European Medicines Agency (EMA. So far, several TCM herbal quality monographs were adopted by the United States Pharmacopoeia including Chinese Salvia, Ganoderma lucidum and Panax notoginseng, etc. Over 45 TCM quality monographs were recorded in the European Pharmacopoeia with 20 more in progress. After the successful registration of the first TCM product named Diao Xin Xue Kang as traditional medicine via the Medicines Evaluation Board of the Netherlands, several other TCM herbal products are in the registration process in several European member states. So far, there has been still not any TCM product authorized as a drug by the FDA regardless of a few TCM products in phase III or phase II clinical trials. This review summarizes the progress made in the globalization of traditional Chinese medicines in recent years and future issues in this regard.

  7. Recent advances in ultra-high performance liquid chromatography for the analysis of traditional chinese medicine

    Science.gov (United States)

    Traditional Chinese medicines (TCMs) have been widely used for the prevention and treatment of various diseases for thousands of years in China. Ultra Performance Liquid Chromatography (UHPLC) is a relatively new technique offering new possibilities in liquid chromatography. This paper reviews recen...

  8. [Application of Nida's theory in English translation of traditional Chinese medicine].

    Science.gov (United States)

    Li, Yong-an; Li, Jing-yun

    2006-09-01

    The famous American translation theorist Eugene A. Nida has put forward lots of viewpoints and theories for translation work when he translated the Bible, which have important practical instructional meaning for translation of traditional Chinese medicine nowadays. The application of Nida's theories to translating practice of TCM is illustrated by specific examples in this paper.

  9. Fifty-Four Infantile Intractable Diarrhea Patients Treated with Integrated Traditional Chinese and Western Medicine

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Infantile intractable diarrhea (IID) was usually complicated with malnutrition, growth retardation and pulmonary infection, etc. It is difficult to cure, and mortality is rather high. The authors used integrated traditional Chinese and western medicine therapy to treat it, and satisfactory result has been obtained and reported as follows.

  10. A General Introduction of HIV/AIDS Treatment with Traditional Chinese Medicine in China

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    This paper gives a general introduction of HIV/AIDS treatment with Traditional Chinese Medicine (TCM) in China during the past 20 years. Although the role of TCM in treatment of HIV/AIDS is promising, there is still a long way to go.

  11. Integrated Traditional Chinese and Western Medicine in Treating 37 Psoriatic Patients

    Institute of Scientific and Technical Information of China (English)

    LIU; Hong-pu

    2001-01-01

    Psoriasis is a kind of chronic relaptic skin disease, and at present there are no appropriate therapeutical methods. From March 1998 to May 1999, we used the traditional Chinese and western medicine (TCM-WM) approach in treating this disease, and satisfactory result was obtained. We clinically observed this method in treating psoriasis, with hemorrheological examinations performed, and it is reported as follows.

  12. FOULING PREVENTION WITH FLUIDIZED PARTICLES IN EVAPORATION OF TRADITIONAL CHINESE MEDICINE EXTRACT

    Institute of Scientific and Technical Information of China (English)

    Mingyan Liu; Xiulun Li; Ruitai Lin; Wanda Nie; Rucheng Zhang; Ningsheng Ling

    2004-01-01

    The present investigation shows that comparing with the evaporation of vapor-liquid two-phase flow boiling system, heat transfer is enhanced by adding proper inert solid particles into the traditional Chinese medicine liquid which is under evaporation. As a result, fouling prevention effects are evident in such three-phase flow boiling evaporator.

  13. Randomized controlled trial assessing a traditional Chinese medicine remedy in the treatment of primary dysmenorrhea

    NARCIS (Netherlands)

    Kennedy, S.; Jin, X.; Yu, H.; Zhong, S.; Magill, P.; Vliet, T. van; Kistemaker, C.; Voors, C.; Pasman, W.

    2006-01-01

    A proof-of-concept study to assess the safety and efficacy of a traditional Chinese medicine formula as treatment for primary dysmenorrhea showed no statistically significant benefit over placebo. However, some efficacy parameters suggested possible superiority of the active treatment and so a large

  14. [Analysis on layout of traditional Chinese medicine industry based on location quotient].

    Science.gov (United States)

    Chen, Cong; Yu, Yuanyuan; Hu, Yuanjia; Wang, Yitao

    2012-03-01

    To observe the layout and evolution of the traditional Chinese medicine (TCM) medical industry, classify the industry by region and conduct a preliminary study on its professional advantages, competitiveness and possible cause by using the theory of location quotient in regional economics, in order to provide suggestions for the layout of the TCM medical industry.

  15. Use of traditional Chinese medicine in the management of urinary stone disease

    Directory of Open Access Journals (Sweden)

    Ricardo Miyaoka

    2009-08-01

    Full Text Available Objective: To assess the evidence-based literature supporting the use of traditional Chinese medicine Kampo herbal and Acupuncture in stone disease management. Materials and Methods: Four of the most commonly used herbal components of Kampo medicine in the treatment of stone disease are described according to their in vitro and in vivo effects. We also reviewed the role of Acupuncture in urologic clinical setting as well as its proposed mechanisms of action and results. Medline database was assessed using isolated and conjugated key words (Chinese Medicine, Kampo, Chinese Herbal, Calculi, Stone Disease, Kidney, Acupuncture, Herbal Medicine. Articles were reviewed and summarized. Results: Herbal medicine has been proven to be free from side-effects and therefore suitable for long term use therapy. Its antilithic beneficial effects include increased urinary volume, increased magnesium excretion (Takusya, inhibitory activity on calcium oxalate aggregation (Takusya, Wulingsan and Desmodyum styracyfolium, inhibition of calcium oxalate nucleation and hydroxyapatite internalization (Wulingsan. In contrast, acupuncture, has shown to be effective as a pre-treatment anxiolytic and analgesic during colic pain and extracorporeal shock wave lithotripsy treatment, reducing the need for complementary sedative drugs. Conclusion: Chinese traditional medicine is promising as regards its role in stone prevention. An effort must be made in order to standardize study protocols to better assess acupuncture results since each procedure differs in regards to selected acupoints, electrostimulation technique and adjunct anesthetics. Similarly, standardization of Kampo formulations and acceptable clinical endpoints (imaging vs. symptomatic events is needed.

  16. 中药名与中医药文化%Traditional Chinese Medicine Name and Chinese Medical Culture

    Institute of Scientific and Technical Information of China (English)

    何明举

    2014-01-01

    Traditional Chinese medicine name is the carrier of culture of Chinese medicine,the crystallization of marriage of Chinese medicine and cultural art,which contains rich thoughts of humanities and philosophy. Since ancient times,it has spread more,and is a unique cultural landscape in the history of Chinese,it is precious wealth conceived of the development of Chinese medicine business by people,which has shown the cultural characteristics of traditional Chinese medicine incisively and vividly.%中药名是中医药文化的载体,是中医药与文化艺术联姻的结晶,蕴含着丰富的人文科学和哲学思想。自古多有流传,可谓华夏史上一道奇特的文化景观,是人民在千百年的中医药事业奋斗发展中孕育出来的宝贵财富,把中医学的文化特色彰显得淋漓尽致。

  17. Cannabis in Chinese Medicine: Are Some Traditional Indications Referenced in Ancient Literature Related to Cannabinoids?

    Science.gov (United States)

    Brand, E. Joseph; Zhao, Zhongzhen

    2017-01-01

    Cannabis sativa L. (Cannabaceae) has a long history of utilization as a fiber and seed crop in China, and its achenes (“seeds”) as well as other plant parts have been recorded in Chinese medical texts for nearly 2000 years. While the primary applications of cannabis in Chinese medicine center around the use of the achenes, ancient indications for the female inflorescence, and other plant parts include conditions such as pain and mental illness that are the subject of current research into cannabinoids such as cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC). However, little previous research has been conducted to analyze the Chinese medical literature in light of recent advances in the pharmacology and taxonomy of cannabis, and most of the relevant Chinese historical records have not yet been translated into Western languages to facilitate textual research. Furthermore, many key questions remain unresolved in the Chinese literature, including how various traditional drug names precisely correspond to different plant parts, as well as the implications of long-term selection for fiber-rich cultivars on the medical applications of cannabis in Chinese medicine. In this article, prominent historical applications of cannabis in Chinese medicine are chronologically reviewed, and indications found in ancient Chinese literature that may relate to cannabinoids such as CBD and Δ9-THC are investigated. PMID:28344554

  18. Prescription of Chinese Herbal Medicine in Pattern-Based Traditional Chinese Medicine Treatment for Depression: A Systematic Review

    Directory of Open Access Journals (Sweden)

    Wing-Fai Yeung

    2015-01-01

    Full Text Available Traditional Chinese medicine (TCM treatments are often prescribed based on individuals’ pattern diagnoses. A systematic review of randomized controlled trials in Chinese and English literatures on TCM pattern-based treatment for depression has therefore been conducted. A total of 61 studies, 2504 subjects, and 27 TCM patterns were included. Due to the large variation of TCM pattern among participants, we only analyzed the top four commonly studied TCM patterns: liver qi depression, liver depression and spleen deficiency, dual deficiency of the heart, and spleen and liver depression and qi stagnation. We found that Xiaoyao decoction was the most frequently used herbal formula for the treatment of liver qi depression and liver depression with spleen deficiency, while Chaihu Shugan decoction was often used for liver depression and qi stagnation. Bai Shao (Paeonia lactiflora Pall. and Chai Hu (Bupleurum chinense DC. were commonly used across different TCM patterns regardless of the prescribed Chinese herbal formulas. The rationale underlying herb selection was seldom provided. Due to the limited number of studies on TCM pattern-based treatment of depression and their low methodological quality, we are unable to draw any conclusion regarding which herbal formulas have higher efficacy and which TCM patterns respond better to CHM.

  19. Application of Systems Biology Technology in Research of Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    LI Ping; YANG Li-ping; GONG Yue-wen

    2009-01-01

    Systems biology is an emerging science of the 21 st century and its method and design of study resemble those of traditional Chinese medicine (TCM). Adopting systems biology technology will help to understand TCM Syndromes and modernize Chinese herbal medicine. The technology platforms of systems biology,especially proteomics can provide useful tools for exploring essence of TCM syndromes and understanding principle of herbal formulation. Moreover, compared with methods of molecular biology, such as genomics and proteomics, metabolomics provide more direct, rapid, concise and effective methods for study of kidney disease especiallv in the case of prevention and treatment with TCM.

  20. [Controllability pyramid: an integrated control system of quality for traditional Chinese medicines].

    Science.gov (United States)

    Xiao, Xiao-He; Zhang, Ding-Kun; Wang, Jia-Bo; Yang, Ming; Peng, Cheng

    2015-01-01

    Quality control is one of the key scientific tissues in the modernization of traditional Chinese medicines (TCM). In order to overcome the deficiencies of assessment indexes, including little systematization and quantification, as well as loose association with clinical efficacy and dosage, a new integrated method named controllability pyramid ( CP) is first proposed in this paper. In addition, some study cases are used to explain how this model is constructed. We hope the establishment of CP could promote the clinical-orien- ted integrated innovation research of TCM, and provide control strategy and technology examples for improving the quality of Chinese medicines and clinical efficacy.

  1. Traditional Chinese Medicine in the Treatment of Reproductive Disorders of Large Animals in Asia

    Directory of Open Access Journals (Sweden)

    ZH Zuo, TY Zhang, J Chu, Q Zhang, YX Guo, ZQ Shen and C He

    2016-11-01

    Full Text Available Reproductive diseases have been a great threat in large animal herds. Before induction of western medicines, traditional Chinese medicine (TCM that is based on the use of herbal medicine, acupuncture, massage and other forms of therapy has been practiced in China for thousands of years. The foundational text of Chinese medicine dated back to 5th century to 3rd century BCE, humans in China began developing the TCM therapy by maintaining normal homeostasis and body functions. Traditional Chinese medicine prophylaxis is a very different strategy from that of the western medicine, targeting the balance of the diseased animals as compared to the single lesion. Traditional Chinese medicine was also applied to cure ruminant’s reproductive disorders such as infertility, abortion and retained placenta. With the increasing concerns of the antibiotic resistance and drug abuse happened, TCM has acquired re-recognition as compared to western medicines due to eco-friendly consumer-driven developments and less residue in food chains. More importantly, a growing number of active substances or extracts with the reliable efficacy are being identified, meanwhile, the quality control measures are satisfied in the large-scale production already. However, few TCM is recognized to be used internationally as the popular human medication. Even less TCM is prescribed legally to animal industry due to poor understanding TCM philosophy and lack of the right guidelines of the registration. This summary aims to elucidate the TCM application in the treatment of the reproductive disorder in large animals and offer alternative strategies for prophylaxis.

  2. Improved Chiral Separation of (R,S-Goitrin by SFC: An Application in Traditional Chinese Medicine

    Directory of Open Access Journals (Sweden)

    Lixing Nie

    2016-01-01

    Full Text Available Like chemical drugs, research and development of herbal medicine also have a need to resolve enantiomers. To help illustrating the antiviral bioactivity of Isatidis Radix, a widely used traditional Chinese medicine (TCM, supercritical fluid chromatography (SFC was used for analytical and preparative separation of (R,S-goitrin, which was reported as the active ingredient of the herbal. Improved resolution was achieved on Chiralpak IC column, using acetonitrile as the organic modifier, representing a tenfold increase in speed, compared to the previous normal phase HPLC (NPLC method. The newly developed chromatographic method was validated in terms of linearity, precision, limit of detection (LOD, and limit of quantitation (LOQ. Scale-up purification of (R-goitrin and (S-goitrin was performed on a preparative column with >90% total recovery. The absolute stereochemical assignment of the purified isomers was determined through optical rotation study. This attempt explored SFC’s application in chiral research of traditional Chinese medicine.

  3. Improved Chiral Separation of (R,S)-Goitrin by SFC: An Application in Traditional Chinese Medicine.

    Science.gov (United States)

    Nie, Lixing; Dai, Zhong; Ma, Shuangcheng

    2016-01-01

    Like chemical drugs, research and development of herbal medicine also have a need to resolve enantiomers. To help illustrating the antiviral bioactivity of Isatidis Radix, a widely used traditional Chinese medicine (TCM), supercritical fluid chromatography (SFC) was used for analytical and preparative separation of (R,S)-goitrin, which was reported as the active ingredient of the herbal. Improved resolution was achieved on Chiralpak IC column, using acetonitrile as the organic modifier, representing a tenfold increase in speed, compared to the previous normal phase HPLC (NPLC) method. The newly developed chromatographic method was validated in terms of linearity, precision, limit of detection (LOD), and limit of quantitation (LOQ). Scale-up purification of (R)-goitrin and (S)-goitrin was performed on a preparative column with >90% total recovery. The absolute stereochemical assignment of the purified isomers was determined through optical rotation study. This attempt explored SFC's application in chiral research of traditional Chinese medicine.

  4. [Discussion on the main pathogenesis in traditional Chinese medicine and etiology about primary osteoporosis].

    Science.gov (United States)

    Wang, Xin-xiang; Zhang, Yun-ling; Huang, Qi-fu

    2010-12-01

    Osteoporosis is characterized by reduced bone mass and impaired micro-architectural structure, leading to an increased susceptibility to fractures. It is a complex, multifactorial disorder resulting from genetic factors, environmental factors and gene-environment interactions. Currently there are three opinions on the main pathogenesis of primary osteoporosis in traditional Chinese medicine: kidney deficiency, spleen deficiency, and spleen-kidney deficiency, in which disagreement remains. In this paper, the authors combine the modern etiology of osteoporosis to explain scientific connotation of the three opinions, aiming to comprehend the pathogenesis of primary osteoporosis and strengthen the communication between traditional Chinese medicine and Western medicine, and trying to evaluate the clinical curative effect on osteoporosis.

  5. Chinese medicinal herbs as source of antioxidant compounds--where tradition meets the future.

    Science.gov (United States)

    Matkowski, A; Jamiołkowska-Kozlowska, W; Nawrot, I

    2013-01-01

    Medicinal plants are an essential part of Traditional Chinese Medicine (TCM), an ancient complex therapy considered today as one of the most complete complementary medicine system. Chinese Herbal Medicines (CHM) listings included in Chinese Materia Medica cover more than 1500 plants and a great number of composite preparations. Recently, several TCM herbs have been included into European Pharmacopoeia and many more are on the waiting list. The efficiency of TCM is based on the reinforcing of an organism's natural healing power and the ability to restore the energy homoeostasis. A likely mechanism of at least some of the activities is interacting with redox balance and prevention of oxidative stress. During the past two decades, hundreds of crude herbs, extracts, and isolated compounds have been screened for their antioxidant properties in vitro and in vivo. Consequently, some of traditional Chinese herbs can be regarded as source of very efficient antioxidant compounds, and this activity could explain some of their therapeutic and preventive usefulness. In this review, we outline the recent achievements in the worldwide quest for more efficient antioxidants, with Chinese medicinal and food plants in the central point. Various classes of antioxidant compounds will be mentioned, such as polyphenols or terpenoids that can act either as direct reactive oxygen species scavengers, transition metal reducers and chelators, or as chain breaking antioxidants. Some methodological considerations will be also discussed, with emphasis on the potential importance of the results obtained with antioxidant assays for human health and disease prevention. In this context, several examples of selected, most promising Chinese medicinal plants will be also presented in more detail.

  6. Three advantages of using traditional Chinese medicine to prevent and treat tumor

    Institute of Scientific and Technical Information of China (English)

    Chang-quan Ling; Xiao-qiang Yue; Chen Ling

    2014-01-01

    Traditional Chinese medicine (TCM), an important component of complementary and alternative medicine, has evolved over thousands of years with its own unique system of theories, diagnostics and therapies. TCM has been increasingly used in the last decades and become well known for its significant role in preventing and treating cancer. We believe that TCM possesses advantages over Western medicine in specific aspects at a certain stage of cancer treatment. Here we summarize the advantages of TCM from three aspects: preventing tumorigenesis; attenuating toxicity and enhancing the treatment effect; and reducing tumor recurrence and metastasis.

  7. Selected Terms in Traditional Chinese Medicine and Their Interpretations (

    Institute of Scientific and Technical Information of China (English)

    XIE; Zhufan

    2001-01-01

    Treat disease before it arises (治未病) [zhi wei bing]: A preventive perspective in clinical medicine, mainly including two pointspreventive treatment of disease, and early treatment for prevention of complications. Therefore, it is said that a good doctor treats disease before it arises.    Treat according to time, place and person. (因时, 因地, 因人制宜) (因时, 因地, 因人制宜) [yin shi, yin di, yin ren zhi yi]: One of the therapeutic principles referring to the application of different treatment in accordance with climatic and seasonal conditions, geographical localities, and the patient's constitution.    Supporting the normal and dispelling the evil (扶正祛邪) [fu zheng qu xie]: two general principles of treatment which can be applied separately or in combination according to the patient's condition. They are closely correlated, as supporting the normal, i.e., strengthening the body resistance, facilitates the elimination of pathogenic factors, and dispelling the evil, i.e., eliminating the pathogens, promotes the restoration of normal Qi.    Routine treatment (正治) [zheng zhi]: use of medicines opposite in nature to the disease, e.g., to treat heat syndrome with medicines cold or cool in nature, also known as counteracting treatment (逆治) [ni zhi]. This is applied in most cases, such as to treat excess with purgation or reduction (实则泻之) (实则泻之) [shi ze xie zhi], to treat deficiency with tonification or reinforcement (虚则补之) (虚则补之) [xu ze bu zhi], to treat cold with the hot (寒者热之) (寒者热之) [han zhe re zhi], and to treat heat with the cold (热者寒之) (热者寒之) [re zhe han zhi].……

  8. Integrating traditional Chinese medicine into mainstream healthcare system in Hong Kong, China-A model of integrative medicine in the HKU-SZ Hospital

    Institute of Scientific and Technical Information of China (English)

    Lixing Lao; Zhipeng Ning

    2015-01-01

    The European Congress for Integrative Medicine 2015 Global Summit on Integrative Medicine and Healthcare in Greater Copenhagen has successfully promoted integrative medicine to the public once again. Integrative medicine, which is called the art and science of healthcare by Nordic Integrative Medicine, has been widely used in the world. In Hong Kong, integrated traditional Chinese and Western medicine, which is also known as the Chinese version of integrative medicine, provides a valuable reference for the development of integrative medicine in the world. In this article, we introduce the development of traditional Chinese medicine in Hong Kong and an integrated traditional Chinese and Western medicine model in the University of Hong Kong-Shenzhen Hospital.

  9. Integrating traditional Chinese medicine into mainstream healthcare system in Hong Kong, China-A model of integrative medicine in the HKU-SZ Hospital.

    Science.gov (United States)

    Lao, Lixing; Ning, Zhipeng

    2015-11-01

    The European Congress for Integrative Medicine 2015 Global Summit on Integrative Medicine and Healthcare in Greater Copenhagen has successfully promoted integrative medicine to the public once again. Integrative medicine, which is called the art and science of healthcare by Nordic Integrative Medicine, has been widely used in the world. In Hong Kong, integrated traditional Chinese and Western medicine, which is also known as the Chinese version of integrative medicine, provides a valuable reference for the development of integrative medicine in the world. In this article, we introduce the development of traditional Chinese medicine in Hong Kong and an integrated traditional Chinese and Western medicine model in the University of Hong Kong-Shenzhen Hospital.

  10. Effects of Immunopotentiator of the Traditional Chinese Medicine on T Lymphocytes in Chicken Blood

    Institute of Scientific and Technical Information of China (English)

    SHI Qiumei; LI Chunling; GAO Guisheng; SHEN Ping; TANG Shengling

    2008-01-01

    In order to investigate the mechanism of action of immunoenhancer, the effects of the traditional Chinese medicine immunopromoter on the quantity and the transformation rates of T lymphocytes in the chicken blood were determined. Total 120 chickens were randomly assigned into three groups. The 1% and the 0.5% of the Chinese medicine immunopromoter were added to the chicken drinking water, respectively. The quantity of T lymphocytes in each group was measured by a-Naphthyl acetate esterase (ANAE) staining. The results showed that the percentages of T lymphocytes of the treatment groups were significantly higher than that of the control group (P<0.05), and the percentage of the 1% group significantly higher than that of the 0.5% group (P<0.05). In conclusion, the transformation rates of T lymphocytes showed that the Chinese medicine immunopromoter had the significant enhancing effect on the transformation rates of T lymphoeytes of the treated chickens. The traditional Chinese medicine immunopromoter had the distinct function to promote the quantity and the transformation rate of T iymphocytes.

  11. [Investigation on production process quality control of traditional Chinese medicine--Banlangen granule as an example].

    Science.gov (United States)

    Tan, Manrong; Yan, Dan; Qiu, Lingling; Chen, Longhu; Yan, Yan; Jin, Cheng; Li, Hanbing; Xiao, Xiaohe

    2012-04-01

    For the quality management system of herbal medicines, intermediate and finished products it exists the " short board" effect of methodologies. Based on the concept of process control, new strategies and new methods of the production process quality control had been established with the consideration of the actual production of traditional Chinese medicine an the characteristics of Chinese medicine. Taking Banlangen granule as a practice example, which was effective and widespread application, character identification, determination of index components, chemical fingerprint and biometrics technology were sequentially used respectively to assess the quality of Banlangen herbal medicines, intermediate (water extraction and alcohol precipitation) and finished product. With the transfer rate of chemical information and biological potency as indicators, the effectiveness and transmission of the above different assessments and control methods had been researched. And ultimately, the process quality control methods of Banlangen granule, which were based on chemical composition analysis-biometric analysis, had been set up. It can not only validly solute the current status that there were many manufacturers varying quality of Banlangen granule, but also ensure and enhance its clinical efficacy. Furthermore it provided a foundation for the construction of the quality control of traditional Chinese medicine production process.

  12. Speech at the Meeting Commemorating the 50th Anniversary of Chairman MAO Ze-dong's Important Instruction on Western Medicine Doctors Learning Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    CHEN Zhu

    2009-01-01

    @@ Respected leaders, distinguished guests, venerable seniors and comrades, Today, the Meeting Commemorating the 50th Anniversary of Chairman MAO Ze-dong's Important Instructions on Western Medicine Doctors Learning Traditional Chinese Medicine was inaugurated by the Chinese Association of Integrative Medicine, and it is also an important occasion to review the past and look forward to the future.

  13. [Advances of studies on new technology and method for identifying traditional Chinese medicinal materials].

    Science.gov (United States)

    Chen, Shilin; Guo, Baolin; Zhang, Guijun; Yan, Zhuyun; Luo, Guangming; Sun, Suqin; Wu, Hezhen; Huang, Linfang; Pang, Xiaohui; Chen, Jianbo

    2012-04-01

    In this review, the authors summarized the new technologies and methods for identifying traditional Chinese medicinal materials, including molecular identification, chemical identification, morphological identification, microscopic identification and identification based on biological effects. The authors introduced the principle, characteristics, application and prospect on each new technology or method and compared their advantages and disadvantages. In general, new methods make the result more objective and accurate. DNA barcoding technique and spectroscopy identification have their owner obvious strongpoint in universality and digitalization. In the near future, the two techniques are promising to be the main trend for identifying traditional Chinese medicinal materials. The identification techniques based on microscopy, liquid chromatography, PCR, biological effects and DNA chip will be indispensable supplements. However, the bionic identification technology is just placed in the developing stage at present.

  14. [Study on relations between transient receptor potential vanilloid 1 and pungent property of traditional Chinese medicines].

    Science.gov (United States)

    Wang, Xing; Zhang, Yan-Ling; Wang, Yun; Ren, Zhen-Zhen; Bao, Hong-Juan; Qiao, Yan-Jiang

    2014-07-01

    The five-flavor theory of traditional Chinese medicines (TCM) and the flavor efficacy generation mechanism has long been focuses and difficulties in studies on traditional Chinese medicinal properties. In this paper, by using the pharmacophore-based virtual screening technique, the authors discussed the relations between the pungent property and transient receptor potential vanilloid 1 (TRPV1) by studying the TCM components' role in regulating TRPV1 ion channel. The results showed that the matching relationship between TRPV1 agonist pharmacophore model and TCM chemical components could identify the active ingredients from pungent herbs. Therefore, the authors proposed that TRPV1 is one of the potential targets for efficient pungent herbs. The pungent property of TCMs is decided by its chemical components, and consistent with the inherited and additive characteristics.

  15. [Brief discourse on development of psychology of modern traditional Chinese medicine].

    Science.gov (United States)

    Zhang, Jinxia; Li, Peng; Wang, Zhen'e

    2014-05-01

    In 1980, Wang Miqu proposed the concept of "The Psychology of Traditional Chinese Medicine (TCM Psychology)". In 1985, "The First National Symposium on Psychology of Traditional Chinese Medicine" was held, and the concept of TCM Psychology was put forward in the symposium, thus declaring the establishment of TCM Psychology, a new disciplinary branch. Since then, 12 national or international academic symposia of TCM Psychology were convened nationwide. Based on inheriting the original TCM, by means of exploring, sorting out and improving, and by combining and integrating with psychology and medical psychology, the theory of TCM Psychology was thus gradually innovated, and a systematic knowledge of TCM Psychology was set up and utilized in the clinical practice extensively.

  16. [The Theory and Practice of Health Cultivation Qigong Exercise in Traditional Chinese Medicine].

    Science.gov (United States)

    Chang, Mei-Ying

    2015-12-01

    The health cultivation qigong exercise in traditional Chinese medicine refers to a traditional, integrated method of illness prevention and body strengthening, which promotes the functions of qi and the blood, smooths the meridians (energy channels), and balances the viscera and bowels through the regulation of the mind, the breathing, and the body. The concept of using qi to cultivate human life is part of the health cultivation practices of ancient Chinese codes and of Chinese medicine. This concept includes the principles, methods, essences, and clinical applications of the practice. In addition, traditional health cultivation references the concepts of yinyang, viscera and bowels, qi and blood, meridians, and essential energy spirit theory in order to explain the human biological phenomena, the theoretical and practical perspectives of qigong, and the basis of the treatment principle. The health cultivation qigong exercise of Chinese medicine utilizes the concept of the "unity of nature and human beings" in traditional Chinese thinking in its practice, which emphasizes the conformity to nature and seasons. In order to fully leverage the benefits from the purpose of health cultivation in qigong practice, the priority is to understand the health cultivation mechanism, the essentials/matters, and the precautions of qigong practices. Recently, the evidence regarding both the biological and the psychological benefits of qigong practices have been demonstrated in numbers of research articles. In particular, qigong is currently considered to be one of the best mild exercises that is suited to all age groups. Professional nurses are suggested to include the health cultivation qigong exercise as part of activities that target health improvement and illness prevention. Due to the diversity in qigong as practiced by different health cultivation qigong exercise sects, it is essential to accumulate more clinical evidence by conducting greater numbers of rigorous studies

  17. Observational Studies on Evaluating the Safety and Adverse Effects of Traditional Chinese Medicine

    OpenAIRE

    Jung-Nein Lai; Jin-Ling Tang; Jung-Der Wang

    2013-01-01

    Background. This study aims to share our experiences when carrying out observational studies of traditional Chinese medicine (TCM). Methods. We have proactively monitored the safety profiles of Duhuo Jisheng Tang (DJT), Suan Zao Ren Tang (SZRT), and TMN-1. A list of adverse events (AEs), complete blood counts, and liver and kidney function tests were obtained from the participants during their scheduled hospital visits. Retrospective observational studies were conducted based on the reimburse...

  18. Determination of vanadium in food and traditional Chinese medicine by graphite furnace atomic absorption spectroscopy

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Various experimental conditions were described for the vanadium determination by graphite furnace atomic ab-sorption spectroscopy (GFAAS). The experiments showed that when atomization took place under the conditions where thecombination of a pyrolytic coating graphite tube and fast raising temperature were used and the temperature was stable, thesignal peak shapes could be improved, the sensitivity was enhanced, and the memory effect was removed. The vanadium infood and traditional Chinese medicinal herbs can be accurately determined using the standard curve method.

  19. Advances in Experimental Studies on Treatment of Psoriasis by Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    张洪儒; 瞿幸

    2002-01-01

    @@ Psoriasis is a chronic and recurrent dermatosis marked by excessive hyperplasia of epidermal cells. The cause and pathogenesis are unknown. In the last few years, traditional Chinese medicine (TCM) has manifested its strength in treating psoriasis. In order to delve into the mechanism governing the TCM treatment of psoriasis, some clinical and experimental studies were carried out. The following is a review of the advance of the studies since the 1990's.Effects on Proliferation and Differentiation of Keratinocytes (Epithelial Cells)

  20. [Probe in the untranslatability of technical terms in traditional Chinese medicine].

    Science.gov (United States)

    Tang, Si-Min

    2009-02-01

    Based on studying the manifestation of untranslatability of traditional Chinese medicine (TCM) technical terms, and through analysis on the enriched cultural content and special linguistic characteristics, the author summarized the factors that caused the untranslatability, and suggested some projects for compensation and reformation, including transliteration, word-formation, free translation and literal translation. Although the existence of untranslatability of TCM technical terms is affirmable, on account of the uninterrupted international cultural communications, the untranslatability of TCM terms will not be lasting invariable.

  1. Comments on Nigel Wiseman's A Practical Dictionary of Chinese Medicine ( Ⅱ )-- On the Use of Western Medical Terms to Express the Concepts of Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Mr. Wiseman believes that Western medical terms chosen as equivalents of Chinese medical terms should be the words known to all speakers and not requiring any specialist knowledge or instrumentation to understand or identify, and strictly technical Western medical terms should be avoided regardless of their conceptual conformity to the Chinese terms. Accordingly, many inappropriate Western medical terms are selected as English equivalents by the authors of the Dictionary, and on the other hand, many ready-made appropriate Western medical terms are replaced by loan English terms with the Chinese style of word formation.The experience gained in solving the problems of translating Western medical terms into Chinese when Western medicine was first introduced to China is helpful for translating Chinese medical terms into English. How-ever, the authors of the Dictionary adhere to their own opinions, ignoring others experience. The English terms thus created do not reflect the genuine meaning of the Chinese terms, but make the English glossary in chaos. The so-called true face of traditional Chinese revealed by such terms is merely the Chinese custom of word formation and metaphoric rhetoric. In other words, traditional Chinese medicine is not regarded as a system of medicine but merely some Oriental folklore.

  2. 中医手法与人类健康%Traditional Chinese Medicine Technique and Human Health

    Institute of Scientific and Technical Information of China (English)

    王之虹

    2012-01-01

    中医手法包括针法、灸法、推拿、整骨、刮痧、拔罐、功法、针刀等中医特色诊疗手法.作用机制为通过皮部—络脉—经脉—脏腑这一由表及里的疾病防治网络,达到疏通经络、行气活血的目的,进而发挥平衡阴阳、调整脏腑的功能.中医手法是调理人体“亚健康”状态最适宜的手段,在人类健康产业的发展中发挥巨大的作用.%Traditional Chinese medicine technique is characteristic of TCM diagnosis and treatment practices, include acupuncture, moxibustion, TuiNa, osteopathy, GuaSha, cupping, exercises, needle knife, etc. It's mechanism of action isthrough the disease prevention network from the outside to the inside, which is skin areas - collaterals - meridians - organs, to clear the meridians and transport qi and blood,and thus play a balance of yin and yang, adjust the function of organs. Traditional Chinese medicine technique is the most appropriate means to condition the human body "sub - healthy" state. Traditional Chinese medicine technique will play a major role in the developmet of the human health industry.

  3. A New Page for Women's Reproductive Health in Integrated Traditional Chinese and Western Medicine

    Institute of Scientific and Technical Information of China (English)

    YU Jin (俞瑾)

    2003-01-01

    @@ The integrated traditional Chinese and western medicine (ICWM) of obstetrics and gynecology (OBS/GYN) emerged eventually with more than 40 years' hard struggle, and one of the most promising articles is the integration of the masterpieces of menstrual disorder and infertility in TCM and the virtual explosion of new knowledge and methods in reproductive endocrinology in western medicine (WM). More and more articles in ICWM-OBS/GYN have been recognized and accepted by the scholars and patients in the world both theoretically and practically.

  4. Study of Traditional Chinese Medicine--Which Is After All the Right Way?

    Institute of Scientific and Technical Information of China (English)

    CHEN Ke-ji; LI Li-zhi

    2005-01-01

    @@ The study of traditional Chinese Medicine (TCM) with modern research approach has been ongoing for more than half a century. Although great achievement has been made, the progress is less significant when compared with the advance made in other scientific disciplines such as Western medicine (WM). TCM development has reached a crucial point in the era of rapid development of modern sciences and technologies. Whether or not and how to incorporate contemporary sciences and advanced technologies into the study of TCM has been a hot topic discussed in the academics in China.

  5. Screening for Neuraminidase Inhibitory Activity in Traditional Chinese Medicines Used to Treat Influenza

    Directory of Open Access Journals (Sweden)

    Xian-Ying Yang

    2016-08-01

    Full Text Available Objective: To screen for influenza virus neuraminidase inhibition and to provide a reference for the clinical treatment of influenza using traditional Chinese medicines (TCM. In this study, 421 crude extracts (solubilized with petroleum ether, ethanol, ethyl acetate, and aqueous solvents were obtained from 113 TCM. The medicine extracts were then reacted with oseltamivir, using 2’-(4-methylumbelliferyl-α-D-N-acetylneuraminic acid (MUNANA as the substrate, to determine influenza virus neuraminidase activity using a standard fluorimetric assay. It was found that Chinese medicine extracts from Pyrola calliantha, Cynanchum wilfordii, Balanophora involucrata and Paeonia delavayi significantly inhibited neuraminidase activity at a concentration of 40 μg/mL. Dose-dependent inhibitory assays also revealed significant inhibition. The IC50 range of the TCM extracts for influenza virus neuraminidase was approximately 12.66–34.85 μg/mL, respectively. Some Chinese medicines have clear anti-influenza viral effects that may play an important role in the treatment of influenza through the inhibition of viral neuraminidase. The results of this study demonstrated that plant medicines can serve as a useful source of neuraminidase (NA inhibitors and further investigation into the pharmacologic activities of these extracts is warranted.

  6. Plants used in Chinese and Indian traditional medicine for improvement of memory and cognitive function.

    Science.gov (United States)

    Howes, Melanie-Jayne R; Houghton, Peter J

    2003-06-01

    In traditional practices of Ayurvedic and Chinese medicine, numerous plants have been used to treat cognitive disorders, including neurodegenerative diseases such as Alzheimer's disease (AD). An ethnopharmacological approach has provided leads to identifying potential new drugs from plant sources, including those for cognitive disorders. Many drugs currently available in Western medicine were originally isolated from plants, or are derived from templates of compounds isolated from plants. Some anticholinesterase (anti-ChE) alkaloids isolated from plants have been investigated for their potential in the treatment of AD, and are now in clinical use. Galantamine, isolated from several plants including Lycoris radiata Herb., which was used in traditional Chinese medicine (TCM), is licensed in the United Kingdom for the treatment of mild to moderate AD. Various other plant species have shown pharmacological activities relevant to the treatment of cognitive disorders, indicating potential for therapeutic use in disorders such as AD. This article reviews some of the plants and their active constituents that have been used in traditional Ayurvedic medicine and TCM for their reputed cognitive-enhancing or antiageing effects. Plants and their constituents with pharmacological activities that may be relevant for the treatment of cognitive disorders, including enhancement of cholinergic function in the central nervous system (CNS), anti-inflammatory and antioxidant activities, are discussed.

  7. [Study on characteristics of pharmacological effects of traditional Chinese medicines distributing along stomach meridian based on medicinal property combination].

    Science.gov (United States)

    Zhang, Bai-Xia; Gu, Hao; Guo, Hong-Ling; Ma, Li; Wang, Yun; Qiao, Yan-Jiang

    2014-07-01

    At present, studies on traditional Chinese medicine (TCM) properties are mostly restricted to a single or two kinds of medicinal properties, but deviated from the holism of the theoretical system of TCMs. In this paper, the characteristics of pharmacological effects of different property combinations of TCMs distributing in the stomach meridian were take as the study objective. The data of properties of TCMs distributing in the stomach meridian was collected from the Pharmacopoeia of the People's Republic of China (2005). The data of pharmacological effects of TCMs distributing in the stomach meridian was collected from all of literatures recorded in Chinese Journal Full-text Database (CNKI) since 1980, Science of Chinese Materia Medica (Yan Zhenghua, People's Medical Publishing House, 2006) and Clinical Science of Chinese Materia Medica (Gao Xuemin, Zhong Gansheng, Hebei Science and Technology Publishing House, 2005). The corresponding pharmacological effects of property combinations of TCMs distributing in the stomach meridian was mined by the method of association rules. The results of the association rules were consistent with the empirical knowledge, and showed that different medicinal property combinations had respective pharmacological characteristics, including differences and similarities in pharmacological effects of different medicinal property combinations. Medicinal property combinations with identical four properties or five tastes showed similar pharmacological effects; whereas medicinal property combinations with different four properties or five tastes showed differentiated pharmacological effects. However, medicinal property combinations with different four properties or five tastes could also show similar pharmacological effects. In this study, the medicinal property theory and the pharmacological effects of TCMs were combined to reveal the main characteristics and regularity of pharmacological effects of TCMs distributing in the stomach meridian

  8. Antitumor effects of traditional Chinese medicine targeting the cellular apoptotic pathway

    Directory of Open Access Journals (Sweden)

    Xu HL

    2015-05-01

    Full Text Available Huanli Xu,1 Xin Zhao,2 Xiaohui Liu,1 Pingxiang Xu,1 Keming Zhang,2 Xiukun Lin11Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, 2Department of Hepatobiliary Surgery, 302 Hospital of Chinese People’s Liberation Army, Beijing, People’s Republic of ChinaAbstract: Defects in apoptosis are common phenomena in many types of cancer and are also a critical step in tumorigenesis. Targeting the apoptotic pathway has been considered an intriguing strategy for cancer therapy. Traditional Chinese medicine (TCM has been used in the People’s Republic of China for thousands of years, and many of the medicines have been confirmed to be effective in the treatment of a number of tumors. With increasing cancer rates worldwide, the antitumor effects of TCMs have attracted more and more attention globally. Many of the TCMs have been shown to have antitumor activity through multiple targets, and apoptosis pathway-related targets have been extensively studied and defined to be promising. This review focuses on several antitumor TCMs, especially those with clinical efficacy, based on their effects on the apoptotic signaling pathway. The problems with and prospects of development of TCMs as anticancer agents are also presented.Keywords: traditional Chinese medicine, antitumor effects, apoptotic pathway

  9. Feature Extraction for the Wrist-pulse-signals in Traditional Chinese Medicine by Ensemble Empirical Mode Decomposition

    Institute of Scientific and Technical Information of China (English)

    向程; 覃开蓉

    2008-01-01

    @@ Pulse diagnosis plays a vital role in Traditional Chinese Medicine (TCM). To extract effective and properfeatures from the wrist-pulse-signals is a crucial step for the recognition and classification of the pulse signals.

  10. TCM Database@Taiwan: the world's largest traditional Chinese medicine database for drug screening in silico.

    Science.gov (United States)

    Chen, Calvin Yu-Chian

    2011-01-06

    Rapid advancing computational technologies have greatly speeded up the development of computer-aided drug design (CADD). Recently, pharmaceutical companies have increasingly shifted their attentions toward traditional Chinese medicine (TCM) for novel lead compounds. Despite the growing number of studies on TCM, there is no free 3D small molecular structure database of TCM available for virtual screening or molecular simulation. To address this shortcoming, we have constructed TCM Database@Taiwan (http://tcm.cmu.edu.tw/) based on information collected from Chinese medical texts and scientific publications. TCM Database@Taiwan is currently the world's largest non-commercial TCM database. This web-based database contains more than 20,000 pure compounds isolated from 453 TCM ingredients. Both cdx (2D) and Tripos mol2 (3D) formats of each pure compound in the database are available for download and virtual screening. The TCM database includes both simple and advanced web-based query options that can specify search clauses, such as molecular properties, substructures, TCM ingredients, and TCM classification, based on intended drug actions. The TCM database can be easily accessed by all researchers conducting CADD. Over the last eight years, numerous volunteers have devoted their time to analyze TCM ingredients from Chinese medical texts as well as to construct structure files for each isolated compound. We believe that TCM Database@Taiwan will be a milestone on the path towards modernizing traditional Chinese medicine.

  11. Prescription of Chinese Herbal Medicine and Selection of Acupoints in Pattern-Based Traditional Chinese Medicine Treatment for Insomnia: A Systematic Review

    OpenAIRE

    Wing-Fai Yeung; Ka-Fai Chung; Maggie Man-Ki Poon; Fiona Yan-Yee Ho; Shi-Ping Zhang; Zhang-Jin Zhang; Eric Tat-Chi Ziea; Vivian Wong Taam

    2012-01-01

    Traditional Chinese medicine (TCM) treatments are often prescribed based on individuals' pattern diagnoses. A systematic review of Chinese and English literatures on TCM pattern differentiation, treatment principle, and pattern-based treatment for insomnia has therefore been conducted. A total of 227 studies, 17916 subjects, and 87 TCM patterns were analyzed. There was a limited consistency in pattern-based TCM treatment of insomnia across practitioners. Except for Gui Pi Tang, An Shen Ding Z...

  12. Pathogenetic Regulation of Female Precocious Puberty and the Mechanism of Therapy with Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    cai; de-pei

    2001-01-01

    In recent ten-odd years the pathogenetic regulation of female idiopathic precocious puberty was studied in our hospital, in terms of the function of hypothalamic-pituitary-gonadal axis (HPG axis) and the status of skeletal development as indicators. The therapy with Chinese herbal medicine (CHM) in predominance was formulated, according to our understanding of the regulation and Syndrome Differentiation of traditional Chinese medicine (TCM). It has been clinically verified that the therapy could successfully modulate the course of pubertal development and optimize skeletal development in children with precocious puberty. The mechanism of effectiveness of the drugs has been further studied focusing on the neuroendocrine regulation and gene expression with modern medical techniques.……

  13. Pathogenetic Regulation of Female Precocious Puberty and the Mechanism of Therapy with Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    蔡德培; 季志英; 陈伯英; 张炜

    2001-01-01

    @@In recent ten-odd years the pathogenetic regulation of female idiopathic precocious puberty was studied in our hospital, in terms of the function of hypothalamic-pituitary-gonadal axis (HPG axis) and the status of skeletal development as indicators. The therapy with Chinese herbal medicine (CHM) in predominance was formulated, according to our understanding of the regulation and Syndrome Differentiation of traditional Chinese medicine (TCM). It has been clinically verified that the therapy could successfully modulate the course of pubertal development and optimize skeletal development in children with precocious puberty. The mechanism of effectiveness of the drugs has been further studied focusing on the neuroendocrine regulation and gene expression with modern medical techniques.

  14. Traditional Chinese medicine for treatment of liver diseases:progress, challenges and opportunities

    Institute of Scientific and Technical Information of China (English)

    Chang-qing Zhao; Yang Zhou; Jian Ping; Lie-ming Xu

    2014-01-01

    Traditional Chinese medicine (TCM) is commonly used in treating liver diseases worldwide, especially in China. The advantages of using TCM for treatment of liver diseases include: protecting hepatocytes, inhibiting hepatic inlfammation and antiifbrosis in the liver. In this article, we introduce TCM herbal preparations from the Chinese materia medica (such as Fuzheng Huayu) that are typically used for the treatment of liver diseases. Literature surrounding the mechanisms of TCM therapy for treatment of liver diseases is presented and discussed. We propose that side effects of herbal compounds are often under-appreciated, and that more care should be taken in the prescription of potentially hepatotoxic medicines. Further, to deepen the understanding of TCM mechanisms, new techniques and methodologies must be developed. Future studies will lead to the enhancement of clinical outcomes of TCM. As complementary and alternative therapies, TCMs will play an expanding role in the future of liver disease treatment.

  15. Imagery and Traditional Chinese Medicine%意象与中医

    Institute of Scientific and Technical Information of China (English)

    崔蒙; 李海燕; 胡雪琴; 贾李蓉; 杨硕

    2014-01-01

    Imagery and traditional Chinese medicine (TCM) both originated from ancient Chinese philosophy. TCM thinking level, principles, treatment, prescriptions and medicine to guide clinical practice all have been imprinted by"Imagery"mark profoundly. TCM Informatics inherits the thinking characteristics and theoretical basis of TCM, and innovatively uses data and information to research the world of TCM imagery.%意象和中医同源于中国古代哲学。中医学的思维层面和指导实践的理、法、方、药上都带有深刻的“意象”烙印。中医药信息学继承了中医学的思维特点和理论基础,并创新性地运用数据和信息研究中医意象世界。

  16. The Classification of Tongue Colors with Standardized Acquisition and ICC Profile Correction in Traditional Chinese Medicine

    Directory of Open Access Journals (Sweden)

    Zhen Qi

    2016-01-01

    Full Text Available Background and Goal. The application of digital image processing techniques and machine learning methods in tongue image classification in Traditional Chinese Medicine (TCM has been widely studied nowadays. However, it is difficult for the outcomes to generalize because of lack of color reproducibility and image standardization. Our study aims at the exploration of tongue colors classification with a standardized tongue image acquisition process and color correction. Methods. Three traditional Chinese medical experts are chosen to identify the selected tongue pictures taken by the TDA-1 tongue imaging device in TIFF format through ICC profile correction. Then we compare the mean value of L*a*b* of different tongue colors and evaluate the effect of the tongue color classification by machine learning methods. Results. The L*a*b* values of the five tongue colors are statistically different. Random forest method has a better performance than SVM in classification. SMOTE algorithm can increase classification accuracy by solving the imbalance of the varied color samples. Conclusions. At the premise of standardized tongue acquisition and color reproduction, preliminary objectification of tongue color classification in Traditional Chinese Medicine (TCM is feasible.

  17. Mathematical model of biological order state or syndrome in traditional Chinese medicine: based on electromagnetic radiation within the human body.

    Science.gov (United States)

    Han, Jinxiang; Huang, Jinzhao

    2012-03-01

    In this study, based on the resonator model and exciplex model of electromagnetic radiation within the human body, mathematical model of biological order state, also referred to as syndrome in traditional Chinese medicine, was established and expressed as: "Sy = v/ 1n(6I + 1)". This model provides the theoretical foundation for experimental research addressing the order state of living system, especially the quantitative research syndrome in traditional Chinese medicine.

  18. Prospective registration, bias risk and outcome-reporting bias in randomised clinical trials of traditional Chinese medicine

    DEFF Research Database (Denmark)

    Liu, Jian-Ping; Han, Mei; Li, Xin-Xue;

    2013-01-01

    Clinical trials on Traditional Chinese Medicine (TCM) should be registered in a publicly accessible international trial register and report on all outcomes. We systematically assessed and evaluated TCM trials in registries with their subsequent publications.......Clinical trials on Traditional Chinese Medicine (TCM) should be registered in a publicly accessible international trial register and report on all outcomes. We systematically assessed and evaluated TCM trials in registries with their subsequent publications....

  19. Mechanism of Treatment of Kidney Deficiency and Osteoporosis is Similar by Traditional Chinese Medicine.

    Science.gov (United States)

    Wang, Su-Juan; Yue, Wei; Rahman, Khalid; Xin, Hai-Liang; Zhang, Qiao-Yan; Qin, Lu-Ping; Zhang, Hong

    2016-01-01

    Traditional Chinese medicine (TCM) is a theoretical based system and is completely different from western medicine and states that numerous diseases, especially chronic diseases, are cured or relieved. "Zheng" (syndrome) is a summarization of the pathological changes which take place during the different stages of the development of a disease, including its location, cause and nature as well as the state of both Xie-qi (pathogenic factors) and Zheng-qi (healthy energy). Compared to a single symptom, syndrome can demonstrate the nature of a disease more extensively, completely and correctly. However, it is difficult to compare "Zheng" to the western medicine theory, which is based on scientific evidence for the diagnosis and treatment of a specific disease. Estrogen deficiency is a major pathogenetic factor in bone loss after menopause and oophorectomy with the subsequent risk of developing osteoporosis. According to TCM theory, the kidney stores essence and this can transform into bone marrow to nourish the bones, strenghthen the skeleton by promoting growth and repair. The kidney deficiency can decrease the estrogen level adjusted by the gonadal axis, causing osteoporosis. Traditional Chinese medicines tonifying the kidney can significantly enhance the level of estrogen to alleviate osteoporosis. In combination with other evidence, we further deduce that the syndrome as defined within TCM has a similar pathological mechanism to that defined by western medicine. If TCM theory is to be understood and accepted, and further fused with the western medicine theory, the micro pathological basis of TCM syndrome must be investigated extensively, which will lead to bridging the two theories together. The fusion of TCM with western medicine will pay more attention to analyzing the common nature and difference of disease and syndrome. This paper reviews the way forward for new translational advances.

  20. A Disturbance Rejection Framework for the Study of Traditional Chinese Medicine

    Directory of Open Access Journals (Sweden)

    Han Zhang

    2014-01-01

    Full Text Available The traditional Chinese medicine (TCM is explained in the language of engineering cybernetics (EC, an engineering science with the tradition of rigor and long history of practice. The inherent connection is articulated between EC, as a science of interrelations, and the Chinese conception of Wuxing. The combined cybernetic model of Wuxing seems to have significant explaining power for the TCM and could potentially facilitate better communications of the insights of the TCM to the West. In disturbance rejection, an engineering concept, a great metaphor, is found to show how the TCM is practiced, using the liver cancer pathogenesis and treatment as a case study. The results from a series of experimental studies seem to lend support to the cybernetic model of Wuxing and the principles of disturbance rejection.

  1. Review of Traditional Chinese Medicine Fluoritumin Research%紫石英研究概况

    Institute of Scientific and Technical Information of China (English)

    朱传静; 常琳; 康琛; 李曼玲; 罗永明

    2011-01-01

    The literatures on medicine and herbs from ancient time to modern time were collected and studied, and the historical changes of methods processing Fluoritum and the survey of processed in different provinces were summarized.Discusses the original mineral traditional Chinese medicine purple quartz source.Since the Fluoritum first record in "Shengnong Bencaojin" in Han dynasty, after the traditional heritage and development,and sums up the modern purple quartz drug theory.Modern research put forward for the Chinese medicine of the original mineral sources purple quartz for mineral fluorite (CaF2), this is the source of the purple quartz textual research and quality standard provided valuable information.The different processing methods of the change in the composition of the chemical, and puts forward the optimal processing conditions.Summarizes the determination of different traditional Chinese medicine in the content of purple quartz method.Record the Chinese traditional medicine inclinical application of purple quartz various therapeutic and calendar version of China pharmacopoeia.%对中药矿物药紫石英的现代研究进行介绍.通过对古代及现代医药文献进行查阅,整理,分析,总结了紫石英历代用药演变轨迹及现代全国各地用药概况,探讨了中药紫石英的原矿物来源.自汉代始载,经过历代医家的传承与发展,总结出了现代紫石英的用药理论.现代研究提出了中药紫石英的原矿物来源为矿物萤石(CaF2),这为紫石英的来源考证及质量规范提供了宝贵的资料.作者研究了不同炮制方法下的化学成分的变化,并提出了最优的炮制条件;总结了不同的测定中药紫石英中氟化钙含量的方法;整理中药紫石英在临床应用方面的各种疗效及历版的收载情况.

  2. Treatment of 140 cerebral palsied children with a combined method based on traditional Chinese medicine (TCM) and western medicine

    Institute of Scientific and Technical Information of China (English)

    ZHOU Xue-juan; ZHENG Kun

    2005-01-01

    Objective: To observe and evaluate a method that is effective and practical for treatment of cerebral palsied (CP)children in China. Method: The patient's age and disease type and individual specific conditions were considered in choosing therapy methods accordingly: Chinese herbs, acupuncture, auricular seed pressure, point finger pressing, massage, orthopedic hand manipulation, physiotherapy, occupational therapy, language therapy, etc. Meanwhile we created a new CP treatment model that combines hospitalized treatment with family therapy. Results: The majority of CP patients improved greatly in motor and social adaptation capacities after treatment. Wilcoxon paired rank sum test analysis showed that there were significant differences between the data before and after treatment (P<0.01). Conclusion: This combined therapy method, based on traditional Chinese medicine and western medicine plus family supplemental therapy, is an effective and practical treatment strategy for CP children in China.

  3. Promoting integrative medicine by computerization of traditional Chinese medicine for scientific research and clinical practice: The SuiteTCM Project

    Institute of Scientific and Technical Information of China (English)

    Arthur de Sá Ferreira

    2013-01-01

    BACKGROUND:Chinese and contemporary Western medical practices evolved on different cultures and historical contexts and,therefore,their medical knowledge represents this cultural divergence.Computerization of traditional Chinese medicine (TCM) is being used to promote the integrative medicine to manage,process and integrate the knowledge related to TCM anatomy,physiology,semiology,pathophysiology,and therapy.METHODS:We proposed the development of the SuiteTCM software,a collection of integrated computational models mainly derived from epidemiology and statistical sciences for computerization of Chinese medicine scientific research and clinical practice in all levels of prevention.The software includes components for data management (DataTCM),simulation of cases (SimTCM),analyses and validation of datasets (SciTCM),clinical examination and pattern differentiation (DiagTCM,Tongue TCM,and Pulse TCM),intervention selection (AcuTCM,HerbsTCM,and DietTCM),management of medical records (ProntTCM),epidemiologic investigation of sampled data (ResearchTCM),and medical education,training,and assessment (StudentTCM).DISCUSSION:The SuiteTCM project is expected to contribute to the ongoing development of integrative medicine and the applicability of TCM in worldwide scientific research and health care.The SuiteTCM 1.0 runs on Windows XP or later and is freely available for download as an executable application.

  4. [Analysis on medication regularity of modern traditional Chinese medicines in treating melancholia based on data mining technology].

    Science.gov (United States)

    Zhao, Yan-qing; Teng, Jing; Yang, Hong-jun

    2015-05-01

    To analyze the prescription and medication regularities of traditional Chinese medicines in the treatment of melancholia in the Chinese journal full text database (CNKI), Wanfang Data knowledge service platform, VIP, Chinese biomedical literature database (CBM) in based on the traditional Chinese medicine inheritance support platform software, in order to provide reference for further mining traditional Chinese medicines for the treatment of melancholia and new drug development. The traditional Chinese medicine inheritance support platform software V2.0 was used to establish the prescription database of traditional Chinese medicines for treating melancholia. The software integrated data mining method was adopted to analyze four Qis, five flavors, meridian distribution, frequency statistics, syndrome distribution, composition regularity and new prescriptions. Totally 358 prescriptions for treating melancholia were analyzed to determine the frequency of prescription drugs, commonly used drug pairs and combinations and develop 22 new prescriptions. According to this study, prescriptions for treating depression collected in modern literature databases mainly have the effects in soothing liver and resolving melancholia, strengthening spleen and eliminating phlegm, activating and replenishing blood, regulating liver qi, tonifying spleen qi, clearing heat and purging heat, soothing the mind, nourishing yin and tonifying kidney, with neutral drug property and sweet or bitter flavor, and follow the melancholia treatment principle of "regulating qi and opening the mind, regulating qi and empathy".

  5. 中医科学性的再思考%Reconsideration of the Scientific Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    魏睦新; 胡平

    2009-01-01

    Recently, the debates among traditional Chinese medicine and western medicine have never stopped, some people put forward abolishing traditional Chinese medicine or just leaving along Chinese herbs. However tides of opposition had never destroyed traditional Chinese medicine. There must been reasons in it. The deepest reason why traditional Chi-nese medicine can live along lles in its scientific characteristics. So how to develop traditional Chinese medicine should been the point people focus on.%东西方医学的争论近年来从未停止过,有人以"中医不科学"为由,提出废除中医药,或者"废医存药",但一波又一波的反对浪潮从未能摧毁中医,中医之所以能生存下来,必然有其理由.究其内因在于中医是具有科学性的,因此如何发展中医应该是人们重视及研究的焦点.

  6. Traceability and Quality Control in Traditional Chinese Medicine: From Chemical Fingerprint to Two-Dimensional Barcode

    Directory of Open Access Journals (Sweden)

    Yong Cai

    2015-01-01

    Full Text Available Chemical fingerprinting is currently a widely used tool that enables rapid and accurate quality evaluation of Traditional Chinese Medicine (TCM. However, chemical fingerprints are not amenable to information storage, recognition, and retrieval, which limit their use in Chinese medicine traceability. In this study, samples of three kinds of Chinese medicines were randomly selected and chemical fingerprints were then constructed by using high performance liquid chromatography. Based on chemical data, the process of converting the TCM chemical fingerprint into two-dimensional code is presented; preprocess and filtering algorithm are also proposed aiming at standardizing the large amount of original raw data. In order to know which type of two-dimensional code (2D is suitable for storing data of chemical fingerprints, current popular types of 2D codes are analyzed and compared. Results show that QR Code is suitable for recording the TCM chemical fingerprint. The fingerprint information of TCM can be converted into data format that can be stored as 2D code for traceability and quality control.

  7. Traditional Chinese Medicine Use among Patients with Psoriasis in Taiwan: A Nationwide Population-Based Study.

    Science.gov (United States)

    Weng, Shu-Wen; Chen, Bor-Chyuan; Wang, Yu-Chiao; Liu, Chun-Kai; Sun, Mao-Feng; Chang, Ching-Mao; Lin, Jaung-Geng; Yen, Hung-Rong

    2016-01-01

    Traditional Chinese medicine (TCM) has long been used for patients with psoriasis. This study aimed to investigate TCM usage in patients with psoriasis. We analyzed a cohort of one million individuals representing the 23 million enrollees randomly selected from the National Health Insurance Research Database in Taiwan. We identified 28,510 patients newly diagnosed with psoriasis between 2000 and 2010. Among them, 20,084 (70.4%) patients were TCM users. Patients who were female, younger, white-collar workers and lived in urbanized area tended to be TCM users. The median interval between the initial diagnosis of psoriasis to the first TCM consultation was 12 months. More than half (N = 11,609; 57.8%) of the TCM users received only Chinese herbal medicine. Win-qing-yin and Bai-xian-pi were the most commonly prescribed Chinese herbal formula and single herb, respectively. The core prescription pattern comprised Mu-dan-pi, Wen-qing-yin, Zi-cao, Bai-xian-pi, and Di-fu-zi. Patients preferred TCM than Western medicine consultations when they had metabolic syndrome, hepatitis, rheumatoid arthritis, alopecia areata, Crohn's disease, cancer, depression, fatty liver, chronic airway obstruction, sleep disorder, and allergic rhinitis. In conclusion, TCM use is popular among patients with psoriasis in Taiwan. Future clinical trials to investigate its efficacy are warranted.

  8. Traditional Chinese Medicine Use among Patients with Psoriasis in Taiwan: A Nationwide Population-Based Study

    Directory of Open Access Journals (Sweden)

    Shu-Wen Weng

    2016-01-01

    Full Text Available Traditional Chinese medicine (TCM has long been used for patients with psoriasis. This study aimed to investigate TCM usage in patients with psoriasis. We analyzed a cohort of one million individuals representing the 23 million enrollees randomly selected from the National Health Insurance Research Database in Taiwan. We identified 28,510 patients newly diagnosed with psoriasis between 2000 and 2010. Among them, 20,084 (70.4% patients were TCM users. Patients who were female, younger, white-collar workers and lived in urbanized area tended to be TCM users. The median interval between the initial diagnosis of psoriasis to the first TCM consultation was 12 months. More than half (N=11,609; 57.8% of the TCM users received only Chinese herbal medicine. Win-qing-yin and Bai-xian-pi were the most commonly prescribed Chinese herbal formula and single herb, respectively. The core prescription pattern comprised Mu-dan-pi, Wen-qing-yin, Zi-cao, Bai-xian-pi, and Di-fu-zi. Patients preferred TCM than Western medicine consultations when they had metabolic syndrome, hepatitis, rheumatoid arthritis, alopecia areata, Crohn’s disease, cancer, depression, fatty liver, chronic airway obstruction, sleep disorder, and allergic rhinitis. In conclusion, TCM use is popular among patients with psoriasis in Taiwan. Future clinical trials to investigate its efficacy are warranted.

  9. Traditional Chinese medicine "Qing Yi Tang" alleviates oxygen free radical injury in acute necrotizing pancreatitis

    Institute of Scientific and Technical Information of China (English)

    1998-01-01

    AIM To observe the changes in oxygen free radical (OFR) and the curative effect of traditional Chinese medicine "Qing Yi Tang" in acute necrotizing pancreatitis (ANP).METHODS After induction of ANP by injection of sodium taurocholate into pancreatic duct, 16 dogs were randomly divided into control group and Chinese medicine group. Serum amylase, SOD and MDA were determined on postoperative day 1, 2, 4 and 7. The animals were sacrificed on day 7. SOD and MDA in organs were determined, and pathological changes in pancreas were observed.RESULTS As compared with control group, the serum level of amylase (734U/L vs 2783U/L) and MDA (7.8nmol/ml vs 14.8nmol/ml) in Chinese medicine group were decreased on day 7 (P<0.05), while SOD increased significantly (281nU/ml vs 55nU/ml, P<0.01), and similar changes occurred in MDA and SOD in organs, especially in the pancreas; the pathological changes in the pancreas were alleviated as well.CONCLUSION "Qing Yi Tang" is effective in clearing OFRs and alleviating pathological changes in ANP.

  10. The Traditional Chinese Medicine Prescription Pattern of Endometriosis Patients in Taiwan: A Population-Based Study

    Directory of Open Access Journals (Sweden)

    Ruei-Chi Fang

    2012-01-01

    Full Text Available Background. Traditional Chinese medicine (TCM, when given for symptom relief, has gained widespread popularity among women with endometriosis. The aim of this study was to analyze the utilization of TCM among women with endometriosis in Taiwan. Methods. The usage, frequency of service, and the Chinese herbal products prescribed for endometriosis, among endometriosis patients, were evaluated using a randomly sampled cohort of 1,000,000 beneficiaries recruited from the National Health Insurance Research Database. Results. Overall, 90.8% (N=12,788 of reproductive age women with endometriosis utilized TCM and 25.2% of them sought TCM with the intention of treating their endometriosis-related symptoms. Apart from the usage of either analgesics or more than one type of medical treatment, the odds of using TCM and Western medicine were similar in all types of conventional endometriosis treatment. However, endometriosis patients suffering from symptoms associated with endometriosis were more likely to seek TCM treatment than those with no symptoms. There were 21,056 TCM visits due to endometriosis and its related symptoms, of which more than 98% were treated with Chinese herbal products (CHPs. Conclusion. Gui-Zhi-Fu-Ling-Wan (Cinnamon Twig and Poria Pill containing sedative and anti-inflammatory agents is the most commonly prescribed Chinese herbal formula mainly for the treatment of endometriosis-related symptomatic discomfort and the effects of these TCMs should be taken into account by healthcare providers.

  11. Effect of integrated traditional Chinese and Western medicine on SARS:A review of clinical evidence

    Institute of Scientific and Technical Information of China (English)

    Ming-Ming Zhang; Xue-Mei Liu; Lin He

    2004-01-01

    AIM: To assess the possible effect of integrated traditional Chinese and Western medicine on severe acute respiratory syndromes.METHODS: The current available randomized controlled trials of integrated traditional Chinese and Western medicine on SARS were identified through systematically searching literature in any languages or any types of publications.Additional studies of gray literature were also collected.The quality of studies was evaluated by two investigators independently based largely on the quality criteria specified CONSORT. Statistical analysis of the results was performed using RevMan 4.2.0 software developed by the Cochrane Collaboration.RESULTS: Six studies (n = 366) fulfilling the inclusion criteria were found, of which the quality of one study was graded as B, the remaining five were graded as C. Two studies were performed with meta-analysis, the other four studies existed some heterogeneity for which meta-analysis could not be performed, a significant effect on lung infiltrate absorption was found in the treatment groups of these two studies [RR 6.68, 95% CI (2.93, 15.24), P<0.01], there was no significant differences between the mortality [RR 0.86, 95%CI (0.22, 3.29), P = 0.82] and the average dosage of corticosteroid [WMD -39.65, 95% CI (-116.84, 37.54),P = 0.31]. The other three studies also showed significant differences in infiltrate absorption, including national drug No. 2. 3.4 in combination with Western medicine [RR 5.45,95% CI (1.54, 19.26)], compound formulas NO. 1 combined with Western medicine [WMD 0.24, 95% CI (0.02, 0.46)],compound formulas combined with Western medicine [RR 8.06, 95% CI (0.40, 163.21)]. Kangfeidian No.4 in combination with Western medicine had no significant effect on symptom improvement such as loss of dyspnea and cough [RR 1.50,95%CI (0.41, 5.43)] and [RR 1.29, 95%CI (0.30, 5.43)].CONCLUSION: Integrated traditional Chinese and Western medicines has some positive effects on lung infiltrate absorption in SARS

  12. Traditional Chinese medicine Yisui Tongjing relieved neural severity in experimental autoimmune neuritis rat model

    Science.gov (United States)

    Zhang, Erli; Li, Mingquan; Zhao, Jianjun; Dong, Yuxiang; Yang, Xueqin; Huang, Jingbo

    2016-01-01

    Objective To study the effect of Yisui Tongjing (YSTJ) prescription on motor nerve conduction velocity (MNCV) and microstructure of the sciatic nerve in experimental autoimmune neuritis (EAN) rats, the Guillain–Barré syndrome classic animal models. Materials and methods In this study, we established an EAN model in Lewis rats by immunization. We evaluated the potential clinical application of a traditional Chinese medicine YSTJ by intragastric administration and compared its effect with immunoglobulin. The sciatic MNCV was measured by electrophysiology experiment. Hematoxylin–eosin staining and transmission electron microscope analysis were used to determine the pathologically morphological changes before and after YSTJ application. Results We found that application of YSTJ could significantly alleviate the clinical signs in EAN rats. The treatment also increased MNCV in the sciatic nerve compared to that in the untreated nerve. Demyelination in the sciatic nerve in EAN rats was significantly ameliorated, and newly generated myelinated nerve fibers were observed with treatment of high dose of YSTJ. Conclusion This study showed that the traditional Chinese medicine YSTJ was likely to serve as a therapeutic medicine in autoimmune neuropathies, providing an effective and economic means to the treatment of Guillain–Barré syndrome. PMID:27729792

  13. An investigation Into Traditional Chinese Medicine Hospitals in China: Development Trend and Medical Service Innovation

    Science.gov (United States)

    Wang, Liang; Suo, Sizhuo; Li, Jian; Hu, Yuanjia; Li, Peng; Wang, Yitao; Hu, Hao

    2017-01-01

    Background: This paper aims to investigate the development trend of traditional Chinese medicine (TCM) hospitals in China and explore their medical service innovations, with special reference to the changing co-existence with western medicine (WM) at TCM hospitals. Methods: Quantitative data at macro level was collected from official databases of China Health Statistical Yearbook and Extracts of Traditional Chinese Medicine Statistics. Qualitative data at micro level was gathered through interviews and second-hand material collection at two of the top-level TCM hospitals. Results: In both outpatient and inpatient sectors of TCM hospitals, drug fees accounted for the biggest part of hospital revenue. Application of WM medical exanimation increased in both outpatient and inpatient services. Even though the demand for WM drugs was much higher in inpatient care, TCM drugs was the winner in the outpatient. Also qualitative evidence showed that TCM dominated the outpatient hospital service with WM incorporated in the assisting role. However, it was in the inpatient medical care that WM prevailed over TCM which was mostly applied to the rehabilitation of patients. Conclusion: By drawing on WM while keeping it active in supporting and strengthening the TCM operation in the TCM hospital, the current system accommodates the overriding objective which is for TCM to evolve into a fully informed and more viable medical field. PMID:28005539

  14. Traditional Chinese medicine formulas for irritable bowel syndrome: from ancient wisdoms to scientific understandings.

    Science.gov (United States)

    Xiao, Hai-Tao; Zhong, Linda; Tsang, Siu-Wai; Lin, Ze-Si; Bian, Zhao-Xiang

    2015-01-01

    Traditional Chinese Medicine (TCM) serves as the most common alternative therapeutic approach for Western medicine and benefits IBS patients globally. Due to the lack of scientific evidence in the past, TCM formulas were not internationally well recognized as promising IBS remedies. In this review, firstly, we present the etiology and therapy of IBS in terms of traditional Chinese medical theory. Secondly, we summarize the clinical randomized controlled trials (RCTs) of TCM formulas for IBS patients that are available in the literature (from 1998 to September 2013), in which 14 RCTs conducted of high quality were discussed in detail. Of the 14 selected trials, 12 of those concluded that TCM formulas provided superior improvement in the global symptoms of IBS patients over the placebo or conventional medicines. As well, all 14 RCTs suggested that TCM formulas have good safety and tolerability. Last but not least, we explore the pharmacological mechanisms of the anti-IBS TCM formulas available in the literature (from 1994 to September, 2013). Collectively, in combating IBS symptoms, most TCM formulas exert multi-targeting actions including the regulation of neurotransmitters and hormones in the enteric nervous system (ENS), modulation of smooth muscle motility in the gastrointestinal (GI) tract, modulation of the hypothalamic-pituitary-adrenal (HPA) axis, attenuation of intestinal inflammation and restoration of intestinal flora, etc. In conclusion, TCM formulas appear to be promising for IBS treatment. This review provides a useful reference for the public in furthering a better understanding and acceptance of TCM formulas as IBS remedies.

  15. Intervention effect of traditional Chinese medicine Yi Tang Kang on metabolic syndrome of spleen deficiency

    Institute of Scientific and Technical Information of China (English)

    Xiao-Xi Liu; Yan Shi

    2015-01-01

    Objective:To investigate effects of herbal compoundYiTangKang on the spleen deficiency metabolic syndrome.Methods:Forty maleWistar rats were randomly divided into two groups: the normal control group and theMS spleen deficiency syndrome group.The control group rats were fed with standard diet and water, whileMS spleen deficiency syndrome group with high fat diet and low dose intraperitoneal injection ofstreptozocin, which swam to the endurance limit. After12 weeks, theMS spleen deficiency syndrome group was randomly divided into two groups, with13 rats in each group.Rats in model group were fed with high fat diet and continuouly administered with daily saline, and rats in intervention group with high fat diet were trated with traditionalChinese medicinesYiTangKang by gavage,2 mL/200 g at the same time every day.10 weeks later, the expression of serum proteomics was investigated through abdominal aortic puncture and separation of serum, using isotope labeling technique, high performance liquid chromatography and four bar-Orbitrap mass spectrometer.Results:After treatment with traditionalChinese medicine yitangkang, in the model group, important carboxylesterase and retinal guanylatecyclase2 precursor were upregulated.As for intervention group, these indesxes were raised, but immunoglobulinIgG, carnitine acetyltransferase, tubulin beta -5, andGanLu sugar binding proteinC were down-regulated.At the same time, some new biological active substances, such as protein tyrosine kinase, beta glucosidase were also found.Conclusions:TraditionalChinese medicinesYiTangKang could regulate glucose and lipid metabolism in rats with spleen deficiency syndrome.

  16. Recent Progresses in Analysis of Tongue Manifestation for Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    WEI Bao-guo; CAI Yi-heng; ZHANG Xin-feng; SHEN Lan-sun

    2005-01-01

    Tongue diagnosis is one of the most precious and widely used diagnostic methods in Traditional Chinese Medicine (TCM). However, due to its subjective, qualitative and experience-dependent nature, the studies on tongue characterization have been widely emphasized. This paper surveys recent progresses in analysis of tongue manifestation. These new developments include the cross-network and cross-media color reproduction of tongue image, the automatic segmentation of tongue body based on knowledge, the automatic analysis of curdiness and griminess for the tongue fur and the automatic analysis of plumpness, wryness and dot -thorn of tongue body. The clinic experiments verify the validity of these new methods.

  17. [Research on establishment of clinical safety intensive hospital monitoring net of traditional Chinese medicine injection].

    Science.gov (United States)

    Wang, Lian-Xin; Xie, Yan-Ming; Wang, Zhi-Fei

    2012-09-01

    The establishment of clinical safety monitoring net of traditional Chinese medicine (TCM) injection is the one of the key issues of the monitoring work. The monitoring net is including varieties of types of net, such as clinical monitoring net, multimedia network platform, the net of experts or talents. The paper will introduce the establishing method of clinical safety monitoring net, the establishing of clinical safety monitoring net, and the establishing of network based on the internet, the knowledge network construction of experts, the net construction of talents are all included, to assure the development for clinical safety monitoring work.

  18. Significant reduction of sperm disomy in six men: effect of traditional Chinese medicine?

    Institute of Scientific and Technical Information of China (English)

    Helen G. Tempest; Sheryl T. Homa; Xiao-Ping Zhai; Darren K. Griffin

    2005-01-01

    Aim: To test the hypothesis that levels of sperm disomy fell significantly in six men treated by traditional Chinese medicine (TCM). Methods: Fluorescence in situ hybridization (FISH) was done on the sperm heads of six men before and during treatment by TCM. Results: There was a significant reduction in sperm disomy in all six men.This coincided with TCM treatment. Conclusion: This is the first study reporting a significant reduction in sperm disomy in men over a given time course. The fact that this coincided with TCM treatment is intriguing but no conclusions can be drawn from this until placebo-controlled clinical trials are implemented.

  19. The Rise of Traditional Chinese Medicine Among China's Middle Class

    Institute of Scientific and Technical Information of China (English)

    ZHANGHONG

    2005-01-01

    THE renaissance of TCM (Traditional Chinese Medicine)in China hit a new high on December 2 last year,when the renowned practitioner Deng Tietao took on two apprentices,Ding Lei and Liang Dong. The minute this news item hit the country's front pages and TV screens it caused a national sensation. Thirty-four-year-old Ding Lei is founder and CEO of Netease.com and the richest man on the 2003 Fortune China list. His fellow apprentice, Liang Dong, is a popular presenter on Hong Kong-based Phoenix TV, well knownfor his acerbic wit.

  20. Advances in mesenchymal stem cells combined with traditional Chinese medicine therapy for liver fibrosis

    Institute of Scientific and Technical Information of China (English)

    Shu Dong; Shi-bing Su

    2014-01-01

    Liver fibrosis is a primary cause of liver cirrhosis, and even hepatocarcinoma. Recently, the usage of mesenchymal stem cells (MSCs) has been investigated to improve liver ifbrosis. It has been reported that the differentiation, proliferation and migration of MSCs can be regulated by traditional Chinese medicine treatment;however, the mechanisms are still unclear. In this article, the authors review the characteristics of MSCs such as multidirectional differentiation and homing, and its application in animal experiments and clinical trials. The authors also list areas that need further investigation, and look at the future prospects of clinical application of MSCs.

  1. Review: Early metabolism evaluation making traditional Chinese medicine effective and safe therapeutics

    Institute of Scientific and Technical Information of China (English)

    LIU Yong; YANG Ling

    2006-01-01

    Increasing attention is being paid to the scientific evaluation of traditional Chinese medicine (TCM). As many TCMs are capable of biotransformation in the gastrointestinal tract, attention to biotransformation of TCM in the gastrointestinal tract may lead to discovery of the active components and active mechanisms. In this article, we review reports that host metabolic enzymes and intestinal bacteria may be responsible for the metabolism of TCM. Good understanding of the in vivo course of TCM will help us to know how to conduct metabolism evaluation of TCM by using in vitro human-derived system. This evaluation system will create new views on TCM as effective and safe therapeutic agents.

  2. Systems biology technologies enable personalized traditional Chinese medicine: a systematic review.

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    Wang, Xijun; Zhang, Aihua; Sun, Hui; Wang, Ping

    2012-01-01

    Traditional Chinese medicine (TCM), an alternative medicine, focuses on the treatment of human disease via the integrity of the close relationship between body and syndrome analysis. It remains a form of primary care in most Asian countries and its characteristics showcase the great advantages of personalized medicine. Although this approach to disease diagnosis, prognosis and treatment has served the medical establishment well for thousands of years, it has serious shortcomings in the era of modern medicine that stem from its reliance on reductionist principles of experimentation and analysis. In this way, systems biology offers the potential to personalize medicine, facilitating the provision of the right care to the right patient at the right time. We expect that systems biology will have a major impact on future personalized therapeutic approaches which herald the future of medicine. Here we summarize current trends and critically review the potential limitations and future prospects of such treatments. Some characteristic examples are presented to highlight the application of this groundbreaking platform to personalized TCM as well as some of the necessary milestones for moving systems biology of a state-of-the-art nature into mainstream health care.

  3. [Optimization theory and practical application of membrane science technology based on resource of traditional Chinese medicine residue].

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    Zhu, Hua-Xu; Duan, Jin-Ao; Guo, Li-Wei; Li, Bo; Lu, Jin; Tang, Yu-Ping; Pan, Lin-Mei

    2014-05-01

    Resource of traditional Chinese medicine residue is an inevitable choice to form new industries characterized of modem, environmental protection and intensive in the Chinese medicine industry. Based on the analysis of source and the main chemical composition of the herb residue, and for the advantages of membrane science and technology used in the pharmaceutical industry, especially membrane separation technology used in improvement technical reserves of traditional extraction and separation process in the pharmaceutical industry, it is proposed that membrane science and technology is one of the most important choices in technological design of traditional Chinese medicine resource industrialization. Traditional Chinese medicine residue is a very complex material system in composition and character, and scientific and effective "separation" process is the key areas of technology to re-use it. Integrated process can improve the productivity of the target product, enhance the purity of the product in the separation process, and solve many tasks which conventional separation is difficult to achieve. As integrated separation technology has the advantages of simplified process and reduced consumption, which are in line with the trend of the modern pharmaceutical industry, the membrane separation technology can provide a broad platform for integrated process, and membrane separation technology with its integrated technology have broad application prospects in achieving resource and industrialization process of traditional Chinese medicine residue. We discuss the principles, methods and applications practice of effective component resources in herb residue using membrane separation and integrated technology, describe the extraction, separation, concentration and purification application of membrane technology in traditional Chinese medicine residue, and systematically discourse suitability and feasibility of membrane technology in the process of traditional Chinese

  4. [Theory of toxic classification of traditional Chinese medicine and recommendations for revision of China pharmacopeia (volume 1)].

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    Zhao, Junning; Ye, Zuguang

    2012-08-01

    Toxic classification of traditional Chinese medicine, as a contribution of traditional Chinese medicine (TCM) to the recognition of medicinal toxicity and rational use of medicinal materials by Chinese people, is now a great issue related to safe medication, sustainable development and internationalization of Chinese medicine. In this article, the origination and development of toxic classification theory was summarized and analyzed. Because toxic classification is an urgent issue related to TCM industrialization, modernization and internationalization, this article made a systematic analysis on the nature and connotation of toxic classification as well as risk control for TCM industry due to the medicinal toxicity. Based on the toxic studies, this article made some recommendations on toxic classification of Chinese medicinal materials for the revision of China Pharmacopeia (volume 1). From the aspect of scientific research, a new technical guideline for research on toxic classification of Chinese medicine should be formulated based on new biological toxicity test technology such as Microtox and ADME/Tox, because the present classification of acute toxicity of mice/rats can not met the modern development of Chinese medicine any more. The evaluation system and technical SOP of TCM toxic classification should also be established, and they should well balance TCM features, superiority and international requirements. From the aspect of medicine management, list of toxic medicines and their risk classification should be further improved by competent government according to scientific research. In China Pharmacopeia (volume I), such descriptions of strong toxicity, toxicity or mild toxicity should be abandoned when describing medicine nature and flavor. This revision might help promote TCM sustainable development and internationalization, and enhance the competitive capacity of Chinese medicine in both domestic and international market. However, description of strong

  5. Herba Cistanche (Rou Cong-Rong: One of the Best Pharmaceutical Gifts of Traditional Chinese Medicine

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    Zhiming eLi

    2016-03-01

    Full Text Available Cistanche species, known as Rou Cong-Rong in Chinese, are an endangered wild species and are mainly distributed in the arid lands and warm deserts of northwestern China. Within Traditional Chinese Medicine (TCM, Herba Cistanche is applied as a tonic and/or in a formula for chronic renal disease, impotence, female infertility, morbid leucorrhea, profuse metrorrhagia and senile constipation. The chemical constituents of Herba Cistanche mainly consist of volatile oils, non-volatile phenylethanoid glycosides (PhGs, iridoids, lignans, alditols, oligosaccharides and polysaccharides. There have been an increasing number of studies focusing on its bio-activities, including antioxidation, neuroprotection, and antiaging. The objective of this review is to introduce this herb to the world. Its taxonomy, distribution, and corresponding biological functions and molecular mechanisms are addressed in this review.

  6. Herba Cistanche (Rou Cong-Rong): One of the Best Pharmaceutical Gifts of Traditional Chinese Medicine.

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    Li, Zhiming; Lin, Huinuan; Gu, Long; Gao, Jingwen; Tzeng, Chi-Meng

    2016-01-01

    Cistanche species, known as Rou Cong-Rong in Chinese, are an endangered wild species and are mainly distributed in the arid lands and warm deserts of northwestern China. Within Traditional Chinese Medicine (TCM), Herba Cistanche is applied as a tonic and/or in a formula for chronic renal disease, impotence, female infertility, morbid leucorrhea, profuse metrorrhagia, and senile constipation. The chemical constituents of Herba Cistanche mainly consist of volatile oils, non-volatile phenylethanoid glycosides (PhGs), iridoids, lignans, alditols, oligosaccharides, and polysaccharides. There have been an increasing number of studies focusing on its bio-activities, including antioxidation, neuroprotection, and antiaging. The objective of this review is to introduce this herb to the world. Its taxonomy, distribution, and corresponding biological functions and molecular mechanisms are addressed in this review.

  7. Clinical Distribution and Molecular Basis of Traditional Chinese Medicine ZHENG in Cancer

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    Zhen Chen

    2012-01-01

    Full Text Available In traditional Chinese medicine (TCM clinical practice, ZHENG (also known as syndrome helps to guide design of individualized treatment strategies. In this study, we investigated the clinical use of ZHENG in TCM-treated cancer patients by systematically analyzing data from all relevant reports in the Chinese-language scientific literature. We aimed to determine the clinical ZHENG distributions in six common cancers (lung, liver, gastric, breast, colorectal, and pancreatic with the expectation of uncovering a theoretical basis for TCM ZHENG as a clinical cancer treatment. In addition, we also reviewed the molecular basis underlying Xue-Yu (blood stasis, Shi-Re (dampness-heat, Yin-Xu (Yin deficiency, and Pi-Xu (spleen deficiency ZHENG that are commonly found in cancer patients. The results from our summary study provide insights into the potential utility of TCM ZHENG and may contribute to a better understanding of the molecular basis of TCM ZHENG in cancer.

  8. Enhanced stability and antibacterial efficacy of a traditional Chinese medicine-mediated silver nanoparticle delivery system

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    Sun WJ

    2014-11-01

    Full Text Available Wenjie Sun,1,2,* Ding Qu,1,* Yihua Ma,1 Yan Chen,1,2 Congyan Liu,1 Jing Zhou11Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, 2Department of Pharmaceutics, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People’s Republic of China*These authors contributed equally to this workAbstract: Silver nanoparticles (AgNPs are widely used as antibacterial products in various fields. Recent studies have suggested that AgNPs need an appropriate stabilizer to improve their stability. Some antibacterial traditional Chinese medicines (TCMs contain various reductive components, which can not only stabilize AgNPs but also enhance their antimicrobial activity. In this study, we developed a series of novel AgNPs using a TCM extract as a stabilizer, reducing agent, and antimicrobial agent (TCM-AgNPs. A storage stability investigation of the TCM-AgNPs suggested a significant improvement when compared with bare AgNPs. Further, conjugation of TCMs onto the AgNP surface resulted in stronger antimicrobial potency on antibacterial evaluation using Pseudomonas aeruginosa, Staphylococcus epidermidis, and Staphylococcus aureus with minimum inhibitory concentration 50% (MIC50 ratios (and minimum bactericidal concentration 90% [MBC90] ratios of AgNPs to respective TCM-AgNPs as assessment indices. Among these, P. cuspidatum Sieb. et-conjugated AgNPs (P.C.-AgNPs had the advantage of a combination of TCMs and AgNPs and was studied in detail with regard to its synthesis and characterization. The extraction time, reaction temperature, and concentrations of AgNO3 and Polygonum cuspidatum Sieb. et extract were critical factors in the preparation of P.C.-AgNPs. Further, the results of X-ray diffraction and Fourier transform infrared spectroscopy indicated successful preparation of P.C.-AgNPs. In representative studies, P.C.-AgNPs showed a well-defined spherical shape, a homogeneous

  9. The Great Significance of Establishing Strategic Status of Traditional Chinese Medicine (TCM)

    Institute of Scientific and Technical Information of China (English)

    JiaQian; ChengYongjie; ChengGuangman; YangJuping; YingGuangrong

    2005-01-01

    Traditional Chinese Medicine(TCM), based on the philosophic idea of “correlation between man and nature” and “balance of Yin and Yang” and characterized by “integrated concept” and “syndrome identification & treatment determination”, adjusts and activates the self-recuperating ability to rectify its differentiation from normality of human body to meet the goal of preventing and treating diseases mainly by means of traditional Chinese medicinal herbs, acupuncture and moxibustion, etc. The idea of “Human should be in harmony with Nature including bacterium, virus, etc., but not to extemainate microbe in a large scale”, held and promoted by TCM gives, rise to a delicate physiological equilibrium kept between man and microbe and this is just the development trend of medical science in future. For thousands years, TCM has made indelible contribution to the reproduction and prosperity of the Chinese nation, and under the countless attacks of pestilence has never made its people's death in millions, not such as once occurred in Europe. TCM is also characterized by its “simple, convenient, cheap and effective” method of treatment and is especially good at preventing and treating chronic diseases,complicate multi-system diseases and new-type virus diseases. Therefore, only when the sanitation and healthcare system is established can the health of 1.3 billion people in China and the problem of shoaage of doctor and medicine for 900 million rural population and large number of poverty-stricken urban population be solved. It is strongly suggested that five promotion projects, namely: TCM policy and statute guarantee, TCM qualified personnel cultivation, TCM scientific research, development of TCM in rural areas and TCM administrative system reform should be carried out in real earnest to make TCM develop in a sustainable way.

  10. Mechanism of traditional Chinese medicine in the treatment of allergic rhinitis

    Institute of Scientific and Technical Information of China (English)

    GUO Hong; LIU Ming-ping

    2013-01-01

    Objective To review the major progress in mechanism of traditional Chinese medicine (TCM) in the treatment of allergic rhinitis (AR).Methods Contents about the treatment mechanism of TCM in the therapy of AR in this article were obtained from 22 original articles and reviews published in Chinese-and English-language journals.All of the references were searched by use of Pubmed (1997-2012).Results AR is one of the most common and most serious public health problems in children and young people.Many AR patients were worried about the possible adverse effects of synthetic drugs they were taking.Thus,they seek complementary and alternative therapy,such as TCM.TCM emphasized on the importance of holistic convalescence,not just the disease itself.The favorable safety profile of TCM makes well-acceptance by the general population.In the recent decade,more and more studies of TCM for AR are developed.These studies indicated that the treatment of allergic disorders with TCM therapy including herbal medicines and acupuncture are of safety and efficacy.The mechanism of TCM in the treatment of AR has been discussed.It has been reported that a number of the herbs in the Chinese herbal formulae used in the treatment possess anti-allergic,anti-inflammatory or immune modulation activity.Such function include the inhibition of the release or the activity of mast cell mediators (such as histamine),inhibition the induction of inflammation reaction by chemical agents,and down regulation of serum (immunoglobulin E) IgE levels or the activity of lymphocyte and/or macrophage.Conclusions TCM are frequently used concurrently to improve the clinical efficacy.This review is focuses on the description of the actions mechanism of Chinese medicine's approach relevant to the treatment of AR.

  11. Ontology-Oriented Diagnostic System for Traditional Chinese Medicine Based on Relation Refinement

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    Peiqin Gu

    2013-01-01

    Full Text Available Although Chinese medicine treatments have become popular recently, the complicated Chinese medical knowledge has made it difficult to be applied in computer-aided diagnostics. The ability to model and use the knowledge becomes an important issue. In this paper, we define the diagnosis in Traditional Chinese Medicine (TCM as discovering the fuzzy relations between symptoms and syndromes. An Ontology-oriented Diagnosis System (ODS is created to address the knowledge-based diagnosis based on a well-defined ontology of syndromes. The ontology transforms the implicit relationships among syndromes into a machine-interpretable model. The clinical data used for feature selection is collected from a national TCM research institute in China, which serves as a training source for syndrome differentiation. The ODS analyzes the clinical cases to obtain a statistical mapping relation between each syndrome and associated symptom set, before rechecking the completeness of related symptoms via ontology refinement. Our diagnostic system provides an online web interface to interact with users, so that users can perform self-diagnosis. We tested 12 common clinical cases on the diagnosis system, and it turned out that, given the agree metric, the system achieved better diagnostic accuracy compared to nonontology method—92% of the results fit perfectly with the experts’ expectations.

  12. Research progress on natural products from traditional Chinese medicine in treatment of Alzheimer's disease.

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    Gao, Jianjun; Inagaki, Yoshinori; Li, Xuan; Kokudo, Norihiro; Tang, Wei

    2013-04-01

    Alzheimer's disease (AD) is a severe condition in aging societies. Although research on this disease is advancing rapidly, thus far few very effective drugs are available for AD patients. The currently widely used medicines such as donepezil and galantamine transiently improve the symptoms of patients with mild to moderate AD. They are hardly capable of preventing, halting or reversing the progression of this disease. In the long history of development of traditional Chinese medicine, many herbs have been discovered and employed to treat dementia diseases in clinics in China. In recent decades, a number of agents were isolated from these herbs and their efficacies against AD were tested. Some flavonoids, alkaloids, phenylpropanoids, triterpenoid saponins, and polysaccharides were demonstrated to have potential efficacies against AD via targeting multiple pathological changes of this disease. In this article, we reviewed research progress on the efficacies and underlying mechanisms of these agents.

  13. Research advances on the usage of traditional Chinese medicine for neuroprotection in glaucoma

    Institute of Scientific and Technical Information of China (English)

    Xue-song Mi; Jing-xiang Zhong; Raymond Chuen-Chung Chang; Kwok-Fai So

    2013-01-01

    Progressive loss of retinal ganglion cells (RGCs) and their axons is the main pathogenesis of glaucoma.The cause of glaucoma is not fully understood,but the neurodegeneration of glaucoma involves many mechanisms such as oxidative stress,glutamate toxicity and ischemia/reperfusion insult.In order to target these mechanisms,multiple neuroprotective interventions have been investigated to prevent the death of RGCs.Of note are some tonic herbs from the traditional Chinese medicine (TCM) pharmacopeia that have shown neuroprotective effects in glaucoma.TCM differs from Western medicine in that TCM exhibits complicated bioactive components,triggering many signaling pathways and extensive actions on vital organs.Modern scientific approaches have demonstrated some of their underlying mechanisms.In this review,we used Lycium barbarum and Ginkgo biloba as examples to elaborate the characteristics of TCM and their potential applications in neuroprotection in glaucoma.

  14. Discrimination and feature selection of geographic origins of traditional Chinese medicine herbs with NIR spectroscopy

    Institute of Scientific and Technical Information of China (English)

    LIU Shuhua; ZHANG Xuegong; SUN Suqin

    2005-01-01

    With the traditional Chinese medicine herbs angelicae dahuricae radix (ADR or Baizhi) and salviae miltiorrhizae radix (SMR or Danshen) as two examples, this work studies the automatic discrimination of the geographic origins of the herbs using near infrared (NIR) reflectance spectroscopy. Multi-class support vector machine (SVM) is utilized for the purpose, and recursive SVM is utilized to select the feature spectral segments that are decisive for the discrimination. With only 5 and 8 short spectral segments, discriminative accuracies of 92% are achieved on independent test sample sets. This work not only provides a prototype of accurate rapid discriminating systems for quality control of herbal medicines, but also opens new possibilities in studying subtle differences in the chemical compositions of herbs from different cultivation conditions and investigating their associations with the effectiveness of the herbs.

  15. Possible applications for fascial anatomy and fasciaology in traditional Chinese medicine.

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    Bai, Yu; Yuan, Lin; Soh, Kwang-Sup; Lee, Byung-Cheon; Huang, Yong; Wang, Chun-Lei; Wang, Jun; Wu, Jin-Peng; Dai, Jing-Xing; Palhalmi, Janos; Sha, Ou; Yew, David Tai Wai

    2010-06-01

    Research using medical imaging instruments such as computed tomography and magnetic resonance imaging has led to the proposal that the fascial network distributed over the human body is the anatomical basis for the acupoints and meridians of traditional Chinese medicine. Therefore, we put forward a new theory of anatomy called fascial anatomy. In fascial anatomy, a human body is divided into two major systems. One is the supporting-storing system of unspecialized connective tissues. The other is a functional system. An undifferentiated non-specific connective tissue network, with the participation of the nervous and the immune systems, constitutes the supporting-storing system of the human body. The various differentiated functional cells in the body that are supported and surrounded by the supporting-storing system constitute the functional system. The discipline that studies the supporting-storing system and the mutual relationship between this system and the functional system in a living human body is called fasciaology. The establishment of fascial anatomy and fasciaology opens a new research field in anatomy; consequently, fasciaology will play a significant role in biological medicine and traditional Chinese medical research, as well as future clinical practice.

  16. Systems pharmacology for traditional Chinese medicine with application to cardio-cerebrovascular diseases

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    Yingxue Fu

    2014-10-01

    Full Text Available Identified as a treasure of natural herbal products, traditional Chinese medicine (TCM has attracted extensive attention for their moderate treatment effect and lower side effect. Cardio-cerebrovascular diseases (CCVD are a leading cause of death. TCM is used in China to prevent and treat CCVD. However, the complexity of TCM poses challenges in understanding the mechanisms of herbs at a systems-level, thus hampering the modernization and globalization of TCM. A novel model, termed traditional Chinese medicine systems pharmacology (TCMSP analysis platform, which relies on the theory of systems pharmacology and integrates absorption, distribution, metabolism, excretion and toxicity (ADME/T evaluation, target prediction and network/pathway analysis, was proposed to address these problems. Here, we review the development of systems pharmacology, the TCMSP approach and its applications in the investigations of CCVD and compare it with other methods. TCMSP assists in uncovering the mechanisms of action of herbal formulas used in treating CCVD. It can also be applied in ascertaining the different syndrome patterns of coronary artery disease, decoding the multi-scale mechanisms of herbs, and in understanding the mechanisms of herbal synergism.

  17. Traditional Chinese Medicine QPYF as Preventive Treatment for Clostridium difficile Associated Diarrhea in a Mouse Model

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    Guo Ya-Nan

    2016-01-01

    Full Text Available Traditional Chinese medicine QPYF has a good effect for treating antibiotic-associated diarrhea in clinical practice. The aim of this study is to test its efficacy to prevent Clostridium difficile associated diarrhea (CDAD in a mouse model. C57BL/6 mice were infected with Clostridium difficile VPI 10463 after exposure to antimicrobial mixture. QPYF was administered from 7 days prior to Clostridium difficile infection to 20 days after infection, and its effect was compared with no treatment and receiving placebo. The mice were monitored for 20 days and the percent survival, disease activity index, weight loss, colon histopathology, and the levels of toxins in the feces were measured. The expressions of TNF α, MCP-1, NF-κB p65, and phospho-NF-κB p65 in the colon were presented by immunohistochemistry. The survival rate of QPYF group (93.75% was higher than that of model control group (65%. The mice treated with QPYF had a lower weight loss and disease activity index, compared to the mice with placebo. A significantly lower level of histopathology scores, toxins in the feces, and TNF α, MCP-1, NF-κB p65, and phospho-NF-κB p65 were detected for QPYF-treated mice. Traditional Chinese medicine QPYF showed a good preventive effect for CDAD in a mouse model.

  18. Evaluation on Common Hand, Foot and Mouth Disease Treated by Integrative Traditional Chinese Medicine and Western Medicine

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

    Objective To evaluate the efifcacy and safety of traditional Chinese medicine (TCM) combined with Western medicine in the treatment of patients with common hand, foot and mouth disease (HFMD) by conducting a prospective, controlled, and randomized trial. Methods A total of 452 patients with common HFMD were randomly assigned to receive Western medicine alone (n=220) or combined with TCM (Reduning or Xiyanping injections) (n=232). The primary outcome was the incidence rate of rash/herpes disappearance within 5 days, while secondary outcomes included the incidence rate for fever, cough, lethargy, agitation, and vomiting clearance within 5 days. Results The rash/herpes disappearance rate was 45.5% (100/220) in Western medicine therapy group, and 67.2% (156/232) in TCM and Western medicine combined therapy group, with significant difference (P Conclusions It’s suggested that the integrative TCM and Western medicine therapy achieved a better therapeutic efficacy. TCM may become an important complementary therapy on relieving the symptoms of HFMD.

  19. Application and Perspectives of Traditional Chinese Medicine in the Treatment of Liver Cancer

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    Xia Mao

    2015-01-01

    Full Text Available Liver cancer is one of the most fatal cancers worldwide, the management of which demands a multidisciplinary approach. Conventional therapies such as surgery, chemotherapy, and radiotherapy have gained reasonable success. However, most of these patients experience a severe torment, both mentally and physically. Numerous studies have indicated that traditional Chinese medicine (TCM, when used in conjunction with conventional allopathic therapies, can enhance their efficacy and diminish the resulting side effects and complications. Therefore, a deeper understanding of TCM is of immense help to physicians and other health care providers in providing a better care to patients. TCM is proved to be efficacious in terms of suppressing tumor progression, improving immune system function, and increasing the sensitivity to chemo- and radio-therapies. Although TCM can be delivered in various dosage forms, pills, decoctions, and injections are the three most commonly used forms in treating liver cancer. While these traditional dosage forms limits the usage of herbal medicines to their full potential novel TCM delivery forms such as nanoparticles can enhance the bioavailability, reduce any associated side effect, achieve targeted delivery, and improve the acceptance of TCM by patients. This review summarizes the current application of TCM in different prescriptions and dosage forms in the treatment of liver cancer, along with their advantages and disadvantages, all of which is believed to contribute to better understanding of Chinese herbal medicines as an essential part in the treatment of liver cancer and the importance of this trend to combine TCM and western medicine in novel dosage forms for a better management of the condition.

  20. The Potential of Traditional Chinese Medicine in the Treatment and Modulation of Pain.

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    Du, Guan-Hua; Yuan, Tian-Yi; Du, Li-da; Zhang, Yong-Xiang

    2016-01-01

    Pain is an unpleasant sensory and emotional experience associated with various diseases. Extensive research has been conducted to find appropriate methods of relieving pain and improving the quality of life. However, the most commonly used pain-relieving agents such as opioid therapeutics are often associated with harmful side effects; moreover, users are prone to become addicted to these agents and may develop tolerance. Often, nonopioid therapeutics is only marginally effective, thus leading to a significant unmet medical need. Scientists have studied herbal medicines, finding more than 800 kinds of traditional Chinese medicine (TCM) to be effective in relieving pain while also creating several monomeric compounds to develop novel analgesic drugs. In this review, we summarize the representative TCM currently available for the treatment and modulation of pain. Ten different natural products, mainly herbs, used in Chinese medicine to relieve pain are discussed in light of the theories of TCM and modern pharmacology. We hope that this review will provide valuable information for future studies on the potential of TCM in alleviating pain.

  1. Traditional Chinese and Indian medicine in the treatment of opioid-dependence: a review

    Science.gov (United States)

    Doosti, Fatemeh; Dashti, Saeedeh; Tabatabai, Seyed Meghdad; Hosseinzadeh, Hossein

    2013-01-01

    Objective: In this study, the current literatures on the use of herbs and herbal preparations of Traditional Chinese and Indian Medicine for the treatment of opioid addiction were reviewed. Matherials and Methods: Search was done in databases such as Pub Med, Science Direct, Scopus, Springer Link, and Google Scholar. Results: Among 18 retrieved studies, 3 studies were about asafetida extract, an approved preparation for ameliorating drug abstinence in China. Chinese preparations including Composite Dong Yuan Gao, Qingjunyin and TJ-97 (a water extract of dai-bofu-to) as well as Indian ones, Mentate and Shilajit, were reported to have positive effects against opioid withdrawal, dependence, and tolerance. Moreover, Levo-tetrahydropalmatine and L-Stepholidine, in addition to extracts of Caulis Sinomenii and Sinomenium acutum showed similar effects. Banxia Houpu Decoction, Fu-Yuan pellet, Jinniu capsules, Qingjunyin, Tai-Kang-Ning capsule, and Xuan Xia Qudu Jiaonang (WeiniCom) from Chinese preparations, showed anti-addiction effects in randomized, double-blind and, in some studies, multicenter clinical trials. Conclusion : Traditional herbal preparations of China and India have anti-addiction effects with less adverse effects than alpha2-adrenergic or opioid agonists. PMID:25050276

  2. Traditional Chinese and Indian medicine in the treatment of opioid-dependence: a review

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    Fatemeh Doosti

    2013-05-01

    Full Text Available Objective: In this study, the current literatures on the use of herbs and herbal preparations of Traditional Chinese and Indian Medicine for the treatment of opioid addiction were reviewed. Methods: Search was done in databases such as Pub Med, Science Direct, Scopus, Springer Link, and Google Scholar. Results: Among 18 retrieved studies, 3 studies were about asafetida extract, an approved preparation for ameliorating drug abstinence in China. Chinese preparations including Composite Dong Yuan Gao, Qingjunyin and TJ-97 (a water extract of dai-bofu-to as well as Indian ones, Mentate and Shilajit, were reported to have positive effects against opioid withdrawal, dependence, and tolerance. Moreover, Levo-tetrahydropalmatine and L-Stepholidine, in addition to extracts of Caulis Sinomenii and Sinomenium acutum showed similar effects. Banxia Houpu Decoction, Fu-Yuan pellet, Jinniu capsules, Qingjunyin, Tai-Kang-Ning capsule, and Xuan Xia Qudu Jiaonang (WeiniCom from Chinese preparations, showed anti-addiction effects in randomized, double-blind and, in some studies, multicenter clinical trials. Conclusion: Traditional herbal preparations of China and India have anti-addiction effects with less adverse effects than alpha2-adrenergic or opioid agonists.

  3. Identifying Knowledge Sharing Barriers in the Collaboration of Traditional and Western Medicine Professionals in Chinese Hospitals: A Case Study

    Science.gov (United States)

    Zhou, Lihong; Nunes, Miguel Baptista

    2012-01-01

    This paper reports on a research project that aims at identifying knowledge sharing (KS) barriers between traditional and western medicine practitioners co-existing and complementing each other in Chinese healthcare organisations. The study focuses on the tacit aspects of patient knowledge, rather than the traditional technical information shared…

  4. 寓传统医德于医学院校的中医教学%Instilling traditional medical ethics into traditional Chinese medicine education of medicine institutions

    Institute of Scientific and Technical Information of China (English)

    梁晓春

    2011-01-01

    The ethics of Traditional Chinese Medicine are an important component of Chinese excellent traditional culture,which reflect the interests and expectations of working people.Because it justice but depreciating benefit',it has become the code of conduct for doctors to regulate,restrain,and spur themselves for thousands of years.Under the impacts of market economy,the traditional ethics is hard for young medical students to avoid money worship and other unhealthy thoughts.Therefore,it is essential to instill the merits of traditional medical ethits into the education of Traditional Chinese Medicine in western institutions.in older to lay a good foundation for the country to cultivate medical talents with excellent medical skills and gracious medical ethics.It Can be convinced that if the ethics of traditional Chinese medicine of long standing integrated with modem think well,it will recreate the enormous times value to the traditional ethics.%中医传统医德是中华优秀传统文化的重要组成部分.她反映了广大劳动人民的利益和愿望,崇尚"生命至重"的信念,倡导"医乃仁术"的思想,强调"医贵乎精"的理念,恪守"贵义贱利"的准则,是数千年来医生规范自我、独善其身、鞭策奋进的行为规范.在当今市场经济的冲击下,青年医学生难免受到拜金主义等不健康思想的影响.因此,有必要把传统医德的内容贯穿于医学院校的中医教学之中,为国家培养医德高尚、医术高超的医学人才打下良好的基础.

  5. MULTISENSOR SYSTEM APPLICATION FOR PREPARATIONS BITTERNESS EVALUATION IN TRADITIONAL CHINESE MEDICINE

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    I.S. Yaroshenko

    2014-07-01

    Full Text Available This paper deals with the study of preparations based on medicinal plants used in traditional Chinese medicine for treatment and prevention of a wide range of diseases. The purpose of this research was evaluation of the capabilities of a multisensor system for instrumental assessment of the samples bitterness. 33 samples of medicinal plants were evaluated by tasters according to bitterness intensity from 0 to 6. Methodology of the analysis was developed and repeated measurements of the samples were performed by multisensor system. Tasters’ assessments were used as reference data while multisensor system calibrating. A regression model built according to these data displayed good correlation of the system response with bitterness perceived by people. The parameters of the regression model give the possibility for concluding that the multisensor system is capable to predict the bitterness of the medicinal plants preparations with average precision equal to ±1 of the reference bitterness scale. Relative error of bitterness determination is 14%, which is a good result for such type of measurements (typical error of the taster’s assessment is, as a rule, in the range of 15-30 %.

  6. Traditional Chinese medicine ZHENG and Omics convergence: a systems approach to post-genomics medicine in a global world.

    Science.gov (United States)

    Wang, Peng; Chen, Zhen

    2013-09-01

    Traditional Chinese medicine (TCM) is a comprehensive system of medical practice that has been used to diagnose, treat, and prevent illnesses for more than 3000 years. ZHENG (also known as "syndrome") differentiation remains the essence of TCM. In China, TCM shares equal status, and integrated with Western medicine in the healthcare system to treat many types of diseases. Yet, compared to biomolecular science and Western medicine, the ZHENG/TCM approach to diagnostics might appear unobjective, but offers at the same time long-standing clinical and phenotypic-rich insights. With the current globalization of life sciences and the arrival of "Big Data" research and development, these two silos of medical lore are rapidly coalescing. The applications of multi-omics strategies to TCM have begun to provide novel insights into the essence and molecular basis of TCM ZHENG. We searched the Chinese electronic databases and PubMed for published articles related to "Omics" and "TCM ZHENG" and observed a dramatic increase in studies over the past few years. In this article, we provide a timely synthesis of the lessons learned, and the emerging applications of omics science in TCM ZHENG research. We suggest that the global health scholarship and the field of "developing world Omics" can usefully draw from TCM, and vice versa.

  7. 中医药治疗多梦证%Traditional Chinese Medicine Treatment of dreaminess

    Institute of Scientific and Technical Information of China (English)

    宁式颖; 杨玉赫; 宋锐; 惠文佳; 张博; 郑璐

    2016-01-01

    TCM holds that the body's viscera,qi and blood,yin and yang imbalance,such as modern damage, phlegm fire disturbance,deficiency of yin and anaemia,fatigue to excessive,diet dishonor etiology and pathogenesis is dreaminess. In order to the etiology and pathogenesis,traditional Chinese medicine therapy for dreaminess according to the different type of syndrome differentiation,to invigorate the kidney and nourishing yin,tonifying qi blood as the main therapeutic principle,at the same time and phlegm,spleen,lung and other laws. Plus acupuncture,ear pressure thera-py,medicinal food therapy,cupping,massage is also commonly used method for the treatment of dreaminess. Treatment of traditional Chinese medicine therapeutic method and emphasizes the importance of syndrome differentiation and flex-ibility of medcine using which is based on the cause,quantity and content of dreams.%中医学认为,机体脏腑、气血、阴阳失调,如情志损伤、痰火内扰、阴血亏虚、劳欲过度、饮食失节等是多梦证的病因病机。针对这一病因病机,中医药治疗多梦证根据不同的辨证分型,以滋阴补肾、补气补血为主要治则,同时兼以化痰、健脾、养肺等法。另外针灸疗法、耳压疗法、药膳疗法、拔罐按摩也是治疗多梦证的常用方法。临床治疗上根据梦因、梦量、梦境的不同辨证论治,灵活用药。

  8. Utilization of and Attitudes towards Traditional Chinese Medicine Therapies in a Chinese Cancer Hospital: A Survey of Patients and Physicians

    Directory of Open Access Journals (Sweden)

    Jennifer L. McQuade

    2012-01-01

    Full Text Available Background. In China, the use of traditional Chinese medicine (TCM is very popular, but little is known about how it is integrated with conventional cancer care. We conducted parallel surveys of patients and physicians on TCM utilization. Methods. Two hundred forty-five patients and 72 allopathic physicians at the Fudan University Shanghai Cancer Center completed questions on their use of and attitude towards TCM. Results. Patient mean age was 51, with 60% female. Eighty-three percent of patients had used TCM. Use was greatest for Chinese herbal medicine (CHM; 55.8%. Only 1.3% of patients used acupuncture and 6.8% Qi Gong or Tai Qi. Sixty-three percent of patients notified their oncologist about TCM use. The most common reason for use was to improve immune function. CHM was often used with a goal of treating cancer (66.4%, a use that 57% of physicians agreed with. Physicians were most concerned with interference with treatment, lack of evidence, and safety. Ninety percent of physicians have prescribed herbs and 87.5% have used TCM themselves. Conclusion. The use of TCM by Chinese cancer patients is exceptionally high, and physicians are generally well informed and supportive of patients’ use. Botanical agents are much more commonly used than acupuncture or movement-based therapies.

  9. Design of an FT-NIR spectrometer for online quality analysis of traditional Chinese medicine manufacturing process

    Science.gov (United States)

    Zhu, Ren; Wu, Lan; Wang, Shiming; Ye, Linhua; Ding, Zhihua

    2008-03-01

    As a fast, non-destructive analysis method, Fourier transform (FT) near-infrared (NIR) spectroscopy is very suitable and effective for online quality analysis of traditional Chinese medicine (TCM) manufacturing process. In this thesis, the theoretics of FT-NIRS was analyzed and an FT-NIR spectrometer with 4 cm -1 resolution in the 12500-5000 cm -1 frequency range was designed. The spectrometer was based on a Michelson interferometer with Bromine tungsten lamp as the NIR light source and InGaAs detector to collect the interference signal. Each element was designed and chosen to provide maximum sensitivity in the NIR spectral region. A fiber-optic flow cell system was used to realize online analysis of traditional Chinese medicine. The performance of the spectrometer was evaluated and the feasibility of using FT-NIR spectrometer to get absorption spectra of traditional Chinese medicine was demonstrated.

  10. Utilization of Western Medicine and Traditional Chinese Medicine Services by Physicians and Their Relatives: The Role of Training Background

    Directory of Open Access Journals (Sweden)

    Nicole Huang

    2011-01-01

    Full Text Available Despite extensive efforts to improve the attitude and practice of physicians with respect to complementary and alternative medicine (CAM, the role of training background on physician's own utilization of mainstream Western medicine (WM and CAM remains unclear. We aimed to compare personal utilizations of WM and traditional Chinese medicine (TCM among doctors trained in WM only, TCM only or both. A retrospective population-based study was conducted using the 2004 Taiwan's National Health Insurance data. A total of 103 879 doctors and their relatives and 2 623 658 other adults with equivalent socioeconomic status were analyzed. Ambulatory care utilization of WM and TCM services was compared using the following three measures: probability of any use, number of visits and total annual expenditure. Doctors who were trained in Western medicine only (WMDs had the highest WM use, followed by doctors who were trained in both (WMD-CMDs, while Chinese medicine-trained doctors (CMDs had the lowest use. For TCM use, a reverse pattern was observed. Similar patterns were found among doctors' relatives. Compared with other adults with equivalent socioeconomic status, both the CMDs and WMD-CMDs had a greater use of TCM services. For WM, although the WMDs' probability and frequency of usage were similar to other adults, they incurred considerably higher expenditure. The use of WM and TCM by doctors and their relatives was significantly associated with the training background of the doctors. This highlights the importance of how increasing knowledge and understanding of other medical discipline may influence a practitioner's care-providing behaviors.

  11. [Network pharmacology: new opportunity for the modernization of traditional Chinese medicine].

    Science.gov (United States)

    Liu, Zhi-Hua; Sun, Xiao-Bo

    2012-06-01

    Traditional Chinese medicine (TCM) with the characteristics of holistic view and treatment based on syndrome differentiation, has rich clinical experience thousands of years and demonstrates promising effects to cure complex disease. However, due to the features of multi-component, multi-target and synergistic effect existed in TCM, the effective substances and mechanisms of action are not clear, the qualities of TCM are out of control, and scientific and correct assess system is waiting to be established. The network pharmacology is a novel subject based on the construction of multi-layer networks of disease-phenotype-gene-drug to predict the drug targets in a holistic view, and promote efficiency of drug discovery. Methodologically, network pharmacology integrated the notions of comprehensive research and systematic assessment which agree with the characteristics of holistic view and treatment based on syndrome differentiation in Chinese medicine. Our paper reviewed the challenge and chance within the modernization of TCM, the concept and technology of network pharmacology, and its preliminary application in investigation of TCM. The theoretical system of network pharmacology is emphasized, and the potential prospect of its application in modernization in TCM is focused.

  12. Systems Pharmacology Dissection of the Integrated Treatment for Cardiovascular and Gastrointestinal Disorders by Traditional Chinese Medicine.

    Science.gov (United States)

    Zhang, Wenjuan; Tao, Qin; Guo, Zihu; Fu, Yingxue; Chen, Xuetong; Shar, Piar Ali; Shahen, Mohamed; Zhu, Jinglin; Xue, Jun; Bai, Yaofei; Wu, Ziyin; Wang, Zhenzhong; Xiao, Wei; Wang, Yonghua

    2016-09-06

    Though cardiovascular diseases (CVDs) and gastrointestinal disorders (GIDs) are different diseases associated with different organs, they are highly correlated clinically. Importantly, in Traditional Chinese Medicine (TCM), similar treatment strategies have been applied in both diseases. However, the etiological mechanisms underlying them remain unclear. Here, an integrated systems pharmacology approach is presented for illustrating the molecular correlations between CVDs and GIDs. Firstly, we identified pairs of genes that are associated with CVDs and GIDs and found that these genes are functionally related. Then, the association between 115 heart meridian (HM) herbs and 163 stomach meridian (SM) herbs and their combination application in Chinese patent medicine was investigated, implying that both CVDs and GIDs can be treated by the same strategy. Exemplified by a classical formula Sanhe Decoration (SHD) treating chronic gastritis, we applied systems-based analysis to introduce a drug-target-pathway-organ network that clarifies mechanisms of different diseases being treated by the same strategy. The results indicate that SHD regulated several pathological processes involved in both CVDs and GIDs. We experimentally confirmed the predictions implied by the effect of SHD for myocardial ischemia. The systems pharmacology suggests a novel integrated strategy for rational drug development for complex associated diseases.

  13. Clinical Study on Treatment of Incipient Diabetic Nephropathy by Integrated Traditional Chinese and Western Medicine

    Institute of Scientific and Technical Information of China (English)

    bian; fang

    2001-01-01

    [1]Mogensen CE. Early diabetic renal involvement and nephropathy. In: Alberti KGMM. Krall Lp (eds). The Diabetes Annual(1/3). Amsterdan: Elsevier, 1987∶306-311.[2]WANG XB, SANG Y, KONG XM, et al. Clinical observation on treatment of non-insulin dependent type of diabetes mellitus accompanied with microalbuminuria by Tangshen capsule combining western medicine. CJIM(Chin) 1997;17(10)∶622-623.[3]LU RH. Diagnosis and treatment of diabetes mellitus and its complications by traditional Chinese and western medicine. Beijing: People's Health Publishing House, 1998∶527-531.[4]Febre J, Balant LP, Dayerpa, et al. The kidney in maturity on set diabetes mellitus: a clinical study on 510 patients. Kidney Int 1982;21∶730-738.[5]David M, Neumann L, Lishher M. Plasma lipids and the progression of nephropathy in diabetes mellitus type 2: effect of ACE inhibitors. Kidney Int 1995;47∶907.[6]CAO SF, FANG FZ, AN XY, et al. Significance of microalbuminuria, blood and urine β2-MG and THP in diagnosis of early stage diabetic nephropathy. Chinese J Nephrology 1992;8(3)∶164-165.

  14. Systems Pharmacology Dissection of the Integrated Treatment for Cardiovascular and Gastrointestinal Disorders by Traditional Chinese Medicine

    Science.gov (United States)

    Zhang, Wenjuan; Tao, Qin; Guo, Zihu; Fu, Yingxue; Chen, Xuetong; Shar, Piar Ali; Shahen, Mohamed; Zhu, Jinglin; Xue, Jun; Bai, Yaofei; Wu, Ziyin; Wang, Zhenzhong; Xiao, Wei; Wang, Yonghua

    2016-09-01

    Though cardiovascular diseases (CVDs) and gastrointestinal disorders (GIDs) are different diseases associated with different organs, they are highly correlated clinically. Importantly, in Traditional Chinese Medicine (TCM), similar treatment strategies have been applied in both diseases. However, the etiological mechanisms underlying them remain unclear. Here, an integrated systems pharmacology approach is presented for illustrating the molecular correlations between CVDs and GIDs. Firstly, we identified pairs of genes that are associated with CVDs and GIDs and found that these genes are functionally related. Then, the association between 115 heart meridian (HM) herbs and 163 stomach meridian (SM) herbs and their combination application in Chinese patent medicine was investigated, implying that both CVDs and GIDs can be treated by the same strategy. Exemplified by a classical formula Sanhe Decoration (SHD) treating chronic gastritis, we applied systems-based analysis to introduce a drug-target-pathway-organ network that clarifies mechanisms of different diseases being treated by the same strategy. The results indicate that SHD regulated several pathological processes involved in both CVDs and GIDs. We experimentally confirmed the predictions implied by the effect of SHD for myocardial ischemia. The systems pharmacology suggests a novel integrated strategy for rational drug development for complex associated diseases.

  15. New Development in Traditional Chinese Medicine: Symbolism-Digit Therapy as a Special Naturopathic Treatment.

    Science.gov (United States)

    Li, Shanyu; Xutian, Stevenson

    2016-01-01

    Traditional Chinese medicine (TCM) grew out of traditional Chinese culture. For example, the eight-diagram symbol is composed of the Yang and the Yin. According to oriental philosophy, everything in the universe has a two-sided property, namely an image (or symbol) and a number (or digit). This paper introduces the new concept and historical background of symbolism-digit therapy (SDT), which is a natural therapy for the treatment of various kinds of diseases. SDT is of TCM heritage, which can be traced back to the ancient publications such as Yi Jing, and this heritage has been incorporated into modern development and practices. The successful treatments using SDT presented in this paper use formulas and/or prescriptions in accordance with TCM. All materials presented in this paper come from first-hand clinical observations, which are supported by TCM theories. Effects of SDT treatments are straightforward and worthy of broader and deeper investigation. SDT and other relevant therapies motivate the further exploration of the essence of TCM to improve the understanding of TCM principles.

  16. TREATMENT OF ASTHMA AND FOOD ALLERGY WITH HERBAL INTERVENTIONS FROM TRADITIONAL CHINESE MEDICINE

    Science.gov (United States)

    Li, Xiu-Min

    2014-01-01

    Prevalence of asthma and allergy has increased over the past 2–3 decades in Westernized countries. Despite increased understanding of the pathogenesis of asthma and allergic diseases, control of severe asthma is still difficult. Asthma is also associated with high prevalence of anxiety in particular adolescents. There is no effective treatment for food allergy. Food allergy is often associated with severe and recalcitrant eczema. Novel approaches for treatment of asthma and food allergy and comorbid conditions are urgently needed. Traditional Chinese medicine (TCM), used in Asia for centuries, is beginning to play a role in Western health care. There is increasing scientific evidence supporting the use of TCM for asthma treatment. This review article discusses promising TCM interventions for asthma, food allergy and comorbid conditions and explores their possible mechanisms of action. Since 2005, several controlled clinical studies of “anti-asthma” herbal remedies have been published. Among the herbal medicines, anti-asthma herbal medicine intervention (ASHMI) is the only anti-asthma TCM product that is a US FDA investigational new drug (IND) that has entered clinical trials. Research into ASHMI’s effects and mechanisms of actions in animal models is actively being pursued. Research on TCM herbal medicines for treating food allergy is rare. The herbal intervention, Food Allergy Herbal Formula-2 (FAHF-2) is the only US FDA botanical IND under investigation as a multiple food allergy therapy. Published articles and abstracts, as well as new data generated in preclinical and clinical studies of ASHMI and FAHF-2 are the bases for this review. The effect of TCM therapy on food allergy associated recalcitrant eczema, based on case review, is also included. Laboratory and clinical studies demonstrate a beneficial effect of ASHMI treatment on asthma. The possible mechanisms underlying the efficacy are multiple. Preclinical studies demonstrated the efficacy and

  17. 中药配伍理论研究%Theoretical Research on Compatibility of Traditional Chinese Medicines

    Institute of Scientific and Technical Information of China (English)

    位亚丽; 王志国

    2013-01-01

    中药配伍指中药的配合使用,中药配伍理论体系包括:七情和合、配伍宜忌、君臣佐使以及中药配伍的现代药理学、药效学、毒理学等的现代科学研究.%Compatibility of Traditional Chinese Medicine means to two or more different herbs used together . The theory of compatibility of Traditional Chinese Medicine includes compatibility due to seven emotions ; compatibility taboo; theory of principal, assistant, complement and mediating guide ; as well as pharmacological, pharmacodynamics and toxicology research on compatibility .

  18. Traditional Chinese medicine, acupuncture, and other alternative medicines for prostate cancer: an introduction and the need for more research.

    Science.gov (United States)

    Moyad, M A; Hathaway, S; Ni, H S

    1999-05-01

    There are several other alternative medicines apart from vitamins and minerals that the clinician should be aware of because they have grown in popularity in other fields of medicine. In time, these therapies should impact the arena of urologic oncology. Traditional Chinese Medicine, which includes acupuncture, is an area that has received some attention. The theory behind it can be quite daunting because it is so different from the theory behind Western Medical Science. In addition, exactly how acupuncture can be applied to a patient and its potential use in prostate cancer need to be addressed. Other herbal therapies for the patient experiencing symptoms related to a localized cancer diagnosis also need to be evaluated. St John's Wort for depression and Kava for anxiety are two examples of herbal alternatives that some prostate patients are inquiring about. Finally, Ginkgo biloba has received a great deal of attention in the media for erectile dysfunction, but there is a dearth of evidence in this area and the information that already exists can be misleading until further studies are conducted. Also, it is imperative that additional studies be performed in all of the above subjects as they relate to prostate cancer, but a general survey on alternative medicine use in urologic diseases is needed first before an adequate review of the most popular therapies can be published.

  19. Qualitative and Quantitative Analysis for Facial Complexion in Traditional Chinese Medicine

    Directory of Open Access Journals (Sweden)

    Changbo Zhao

    2014-01-01

    Full Text Available Facial diagnosis is an important and very intuitive diagnostic method in Traditional Chinese Medicine (TCM. However, due to its qualitative and experience-based subjective property, traditional facial diagnosis has a certain limitation in clinical medicine. The computerized inspection method provides classification models to recognize facial complexion (including color and gloss. However, the previous works only study the classification problems of facial complexion, which is considered as qualitative analysis in our perspective. For quantitative analysis expectation, the severity or degree of facial complexion has not been reported yet. This paper aims to make both qualitative and quantitative analysis for facial complexion. We propose a novel feature representation of facial complexion from the whole face of patients. The features are established with four chromaticity bases splitting up by luminance distribution on CIELAB color space. Chromaticity bases are constructed from facial dominant color using two-level clustering; the optimal luminance distribution is simply implemented with experimental comparisons. The features are proved to be more distinctive than the previous facial complexion feature representation. Complexion recognition proceeds by training an SVM classifier with the optimal model parameters. In addition, further improved features are more developed by the weighted fusion of five local regions. Extensive experimental results show that the proposed features achieve highest facial color recognition performance with a total accuracy of 86.89%. And, furthermore, the proposed recognition framework could analyze both color and gloss degrees of facial complexion by learning a ranking function.

  20. Autophagy in cerebral ischemia and the effects of traditional Chinese medicine

    Institute of Scientific and Technical Information of China (English)

    Xiao-ping Huang; Huang Ding; Jin-dong Lu; Ying-hong Tang; Bing-xiang Deng; Chang-qing Deng

    2015-01-01

    Autophagy is a lysosome-mediated degradation process for non-essential or damaged celular constituents, playing an important homeostatic role in cel survival, differentiation and development to maintain homeostasis. Autophagy is involved in tumors as wel as neurodegenerative, cardiovascular and cerebrovascular diseases. Recently, active compounds from traditional Chinese medicine (TCM) have been found to modulate the levels of autophagy in tumor cels, nerve cels, myocardial cels and endothelial cels. Ischemic stroke is a major cause of neurological disability and places a heavy burden on family and society. Regaining function can signiifcantly reduce dependence and improve the quality of life of stroke survivors. In healthy cels, autophagy plays a key role in adapting to nutritional deprivation and eliminating aggregated proteins, however inappropriate activation of autophagy may lead to cel death in cerebral ischemia. This paper reviews the process and the molecular basis of autophagy, as wel as its roles in cerebral ischemia and the roles of TCM in modulating its activity.

  1. Investigation on Therapeutic Mechanisms of Three Principles of Traditional Chinese Medicine for Treating Malignant Tumors

    Institute of Scientific and Technical Information of China (English)

    陆付耳; 黄光英

    2003-01-01

    @@ Tremendous progress was achieved in clinical oncology during the recent decades. The application of the combination therapy on patients with malignant tumors has significantly improved their prognosis, survival rate, and quality of life. The utilization of traditional Chinese medicine (TCM)in the combination therapy has been playing an important role. Analyzing the principles of TCM in treating malignant tumors has demonstrated that the principles of heat-clearing and detoxification (HCD), promoting blood circulation to remove stasis (PBCRS), and strengthening the body resistance and consolidating the constitution (SBRCC), are most frequently Performed and closely related in the clinical practice of cancer therapy. How these therapeutic principles of TCM can treat malignant tumors? The understanding of their therapeutic mechanisms in modern science is helpful to guide their clinical applications.

  2. [Combination analysis of new drug discovery with "Xiaohe Silian" method and traditional Chinese medicine clinical pharmacy].

    Science.gov (United States)

    Liu, Yang; Zhai, Hua-Qiang; Xiang, Jia-Mei; Wang, Jing-Juan; Zhao, Bao-Sheng; Wang, Gang; Dong, Hong-Huan; Ouyang, Guo-Qing

    2014-07-01

    With the kernel of efficacy, "Xiaohe Silian" was a pattern and method for new drug discovery which was constituted with "metabolism-efficacy, toxicity-efficacy, quality-efficacy and structure-efficacy". Its connotation was in keeping with traditional Chinese medicine (TCM) clinical pharmacy. This paper systematically summarized the research method of new drug discovery practice process for TCM. To avoid western drug like in TCM new drug discovery, we carried out combination analysis with TCM clinical pharmacy. The correlation analysis between basic elements of "Xiaohe Silian(n) and TCM clinical pharmacy was studied to guarantee this method could integrate closely with TCM clinic from all angles. Hence, this method aimed to provide a new method for TCM new drug discovery on the basis of TCM clinical pharmacy with insisting on holistic view of multicomponent study, kinetic view of metabolic process when the curative effect occurred and molecular material view of quality control and structure-activity exposition.

  3. Lead Screening for CXCR4 of the Human HIV Infection Receptor Inhibited by Traditional Chinese Medicine

    Directory of Open Access Journals (Sweden)

    Tzu-Chieh Hung

    2014-01-01

    Full Text Available The acquired immunodeficiency syndrome (AIDS is a serious worldwide disease caused by the human immunodeficiency virus (HIV infection. Recent research has pointed out that the G protein-coupled chemokine receptor CXCR4 and the coreceptor C-C chemokine receptor type 5 (CCR5 are important targets for HIV infection. The traditional Chinese medicine (TCM database has been screened for candidate compounds by simulating molecular docking and molecular dynamics against HIV. Saussureamine C, 5-hydroxy-L-tryptophan, and diiodotyrosine are selected based on the highest docking score. The molecular dynamics is helpful in the analysis and detection of protein-ligand interactions. According to the analysis of docking poses, hydrophobic interactions, hydrogen bond variations, and the comparison of the effect on CXCR4 and CCR5, these results indicate Saussureamine C may have better effect on these two receptors. But for some considerations, diiodotyrosine could make the largest variation and may have some efficacy contrary to expectations.

  4. [Optimization method of MOS sensor array for identification of traditional Chinese medicine based on electronic nose].

    Science.gov (United States)

    Zou, Hui-Qin; Liu, Yong; Tao, Ou; Lin, Hui; Su, Yu-Zhen; Lin, Xiang-Long; Yan, Yong-Hong

    2013-01-01

    Optimization of sensor array is a significant topic in the application of electronic nose (EN). Stepwise discriminant analysis and cluster analysis combining with screening of typical index were employed to optimize the original array in the classification of 100 samples from 10 kinds of traditional Chinese medicine based on alpha-FOX3000 EN. And the identification ability was evaluated by three algorithm including principle component analysis, Fisher discriminant analysis and random forest. The results showed that the identification ability of EN was improved since not only the effective information was maintained but also the redundant one was eliminated by the optimized array. The optimized method was eventually established, it was accurate and efficient. And the optimized array was built up, that is, S1, S2, S5, S6, S8, S12.

  5. Integrated Traditional Chinese and Western Medicine in Treating 37 Psoriatic Patients

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@  Psoriasis is a kind of chronic relaptic skin disease, and at present there are no appropriate therapeutical methods. From March 1998 to May 1999, we used the traditional Chinese and western medicine (TCM-WM) approach in treating this disease, and satisfactory result was obtained. We clinically observed this method in treating psoriasis, with hemorrheological examinations performed, and it is reported as follows. METHODS Diagnostic Standard   According to the diagnosis standard in “Modern Dermatology” (chiefly edited by YANG Guo-liang, WANG Xia-sheng. Shanghai: Shanghai Medical University Press, 1996∶513-514), the patients were confirmed to suffer from psoriasis vulgaris; and according to TCM syndrome differentiation as blood stasis type.

  6. Automatic Extraction of Tongue Coatings from Digital Images: A Traditional Chinese Medicine Diagnostic Tool

    Institute of Scientific and Technical Information of China (English)

    Linda Yunlu BAI; SHI Yundi; WU Jia; ZHANG Yonghong; WONG Weiliang; WU Yu; BAI Jing

    2009-01-01

    In traditional Chinese medicine, the coating on the tongue is considered to be a reflection of various pathologic factors. However, the conventional method to examine the tongue lacks an acceptable standard and does not provide the means for sharing information. This paper describes a segmentation method to extract tongue coatings. First, the tongue body was extracted from the original image using the watershed transform. Then, a threshold method was applied to the image to eliminate the light from the camera flash.Finally, a threshold method using the Otsu model in combination with a splitting-merging method was used in the red, green, and blue (RGB) space to extract the thin coating. The combination of the above two methods is applied in the hue, saturation, and value (HSV) space to extract the thick coating. The feasibility of this method is tested by experiments, and the accuracy of segmentation is 95.9%.

  7. [Safety and risk factor analysis on Polygoni Multiflori Radix base on ancient traditional Chinese medicine literatures].

    Science.gov (United States)

    Song, Hai-bo; Du, Xiao-xi; Guo, Xiao-xin; Ren, Jing-tian; Yang, Le; Pang, Yu

    2015-03-01

    Traditional Chinese medicine Polygoni Multiflori Radix is dried roots of Polygonaceae Polygortum multiflorum Thunb. Its clinical application records were first discovered in literatures of the Tang dynasty. The origins, efficacy, toxicity, processing and taboos of Polygoni Multiflori Radix have been discussed in many ancient herb literatures. In recent years, with the increase in the public awareness in health, Polygoni Multiflori Radix admits preparations have been more widely applied in the treatment and prevention of diseases. However, there have been more and more reports about Polygoni Multiflori Radix induced liver injury, the safety of Polygoni Multiflori Radix has increasingly attracted attention of the society. In this paper, the authors summarized and analyzed the toxicity and medication risk factors of Polygoni Multiflori Radix recorded in ancient herb literatures, and proposed that more attention shall be given to the effect of the planting and processing methods on the components and toxicity of Polygoni Multiflori Radix in safety studies, which provides clues for the further studies.

  8. Flavonoid profiling of a traditional Chinese medicine formula of Huangqin Tang using high performance liquid chromatography

    Science.gov (United States)

    Li, Tao; Zhuang, Shuaixing; Wang, Yiwei; Wang, Yanli; Wang, Weihao; Zhang, Huihui; Chen, Li; Wang, Dunfang; Zhou, Zhongming; Yang, Weipeng

    2016-01-01

    The quality control processes for herbal medicines have been problematic. Flavonoids are the major active components of Huangqin Tang (HQT, a traditional Chinese medicine formula). In this study, we used a combinative method approach consisting of chromatographic fingerprinting (high performance liquid chromatography; HPLC), quantitative methods and a pharmacodynamic evaluation model to analyze the flavonoids of HQT obtained from different sources. Ten batches of HQT were analyzed by the HPLC fingerprinting method and 26 common peaks were detected, of which 23 peaks corresponded with the chemical profile of HQT. In addition, 11 major compounds were identified by LC–MS analysis (liquid chromatography–tandem mass spectrometer; LC–MSn) and quantified by the HPLC quantitative method approach. The studied 10 batches of HQT were found to be homogeneous in their composition with a similarity between 0.990 and 1.000. The distribution of the 11 identified compounds was found to be very similar among the batches. Only slight pharmacodynamic differences were detected between the different batches, confirming the homogeneity of HQT. The results of this study prove that the combination of chromatographic fingerprinting and quantitative analysis can be readily used for comprehensive quality control of herbal medicines. PMID:27006899

  9. Study on Incompatibility of Traditional Chinese Medicine: Evidence from Formula Network, Chemical Space, and Metabolism Room

    Directory of Open Access Journals (Sweden)

    Wei Long

    2013-01-01

    Full Text Available A traditional Chinese medicine (TCM formula network including 362 TCM formulas was built by using complex network methodologies. The properties of this network were analyzed including network diameter, average distance, clustering coefficient, and average degree. Meanwhile, we built a TCM chemical space and a TCM metabolism room under the theory of chemical space. The properties of chemical space and metabolism room were calculated and analyzed. The properties of the medicine pairs in “eighteen antagonisms and nineteen mutual inhibitors,” an ancient rule for TCM incompatibility, were studied based on the TCM formula network, chemical space, and metabolism room. The results showed that the properties of these incompatible medicine pairs are different from those of the other TCM based on the analysis of the TCM formula network, chemical space, and metabolism room. The lines of evidence derived from our work demonstrated that the ancient rule of TCM incompatibility, “eighteen antagonisms and nineteen mutual inhibitors,” is probably scientifically based.

  10. Genome sequence of the insect pathogenic fungus Cordyceps militaris, a valued traditional chinese medicine

    Science.gov (United States)

    2011-01-01

    Background Species in the ascomycete fungal genus Cordyceps have been proposed to be the teleomorphs of Metarhizium species. The latter have been widely used as insect biocontrol agents. Cordyceps species are highly prized for use in traditional Chinese medicines, but the genes responsible for biosynthesis of bioactive components, insect pathogenicity and the control of sexuality and fruiting have not been determined. Results Here, we report the genome sequence of the type species Cordyceps militaris. Phylogenomic analysis suggests that different species in the Cordyceps/Metarhizium genera have evolved into insect pathogens independently of each other, and that their similar large secretomes and gene family expansions are due to convergent evolution. However, relative to other fungi, including Metarhizium spp., many protein families are reduced in C. militaris, which suggests a more restricted ecology. Consistent with its long track record of safe usage as a medicine, the Cordyceps genome does not contain genes for known human mycotoxins. We establish that C. militaris is sexually heterothallic but, very unusually, fruiting can occur without an opposite mating-type partner. Transcriptional profiling indicates that fruiting involves induction of the Zn2Cys6-type transcription factors and MAPK pathway; unlike other fungi, however, the PKA pathway is not activated. Conclusions The data offer a better understanding of Cordyceps biology and will facilitate the exploitation of medicinal compounds produced by the fungus. PMID:22112802

  11. Use of traditional Chinese medicine in Singapore children: perceptions of parents and paediatricians.

    LENUS (Irish Health Repository)

    Loh, C H

    2009-12-01

    INTRODUCTION: In a country dominated by western healthcare, interest in traditional Chinese medicine (TCM) is growing. The increasing popularity of TCM, occasionally used with conventional medicine, needs to be assessed, especially in a vulnerable paediatric population. This paper sought to evaluate the use of TCM in children, mainly to determine the common conditions they seek TCM, the pattern of acupuncture or herbal usage for various age groups, the extent of concurrent usage of TCM and conventional medicine, and the reasons for TCM use. Paediatricians\\' perceptions of TCM will allow us to gauge the acceptability of TCM by those who practise conventional medicine. These are assessed in another arm of this study, with a set of predictive characteristics for their personal TCM use, their perceptions of herb\\/acupuncture safety, and their own referral to TCM eventually determined. METHODS: An anonymous questionnaire was administered on 300 parents awaiting consultation at a large TCM clinic. Next, a separate qualitative questionnaire survey form was posted to 100 paediatricians. RESULTS: Herb usage in children is very common (84.3 percent) and 80 percent of parents admitted concurrent usage of TCM and conventional medicine for their children. Drug-herb interactions was an issue of concern for paediatricians. Paediatricians with a higher level of self-reported TCM knowledge were more likely to refer for a cure. CONCLUSION: This was the first study to determine the characteristics of children attending a large TCM clinic in a country which is dominated by western healthcare. It also provided insight into the perceptions of TCM among paediatricians in Singapore. Specifically, it gave us an idea of the predictor traits that determine their referral patterns to TCM and their perceptions of herb and acupuncture safety.

  12. New Progress in Modern Research on Chinese Herbal Medicines Published in Chinese Traditional and Herbal Drugs in 2010: Annual Highlights and Comments

    Institute of Scientific and Technical Information of China (English)

    HE Chun-nian; LIU Yan-ze; XIAO Pei-gen

    2011-01-01

    As a series of and continuous publication,the papers published on Chinese Traditional and Herbal Drugs in 2010 were selectively and briefly highlighted to reflect the new progress on modern research of Chinese herbal medicines.Within 617 articles,chemical constituents (127),pharmaceutics and technology (149),pharmacological studies and clinical observation,and medicinal materials are still major categories.Some comments have also been personally provided.

  13. [Discussion on AIDS etiology, pathogenesis and treatment of traditional Chinese medicine].

    Science.gov (United States)

    Liu, Zhen; Li, Yong

    2013-08-01

    In recent years, Chinese medicine have gotten certain experience and made progress on the treatment of AIDS. Focus on AIDS main pathogenic factors of epidemic toxin and key pathogenesis of "epidemic toxin invasion, vital-Qi deficiency", this paper discuss on Chinese medicine theory of AIDS etiology and pathogenesis, and put forward the theory of "preventive treatment of disease" and enhanced the importance of "strengthening body resistance and eliminating evil" in the treatment of AIDS.

  14. Cancer survivors’ perspectives and experience on western medicine and traditional Chinese medicine treatment and rehabilitation: a qualitative study

    Science.gov (United States)

    Wang, Ji-Wei; Yang, Zhi-Qi; Liu, Cong; Chen, Si-Jia; Shen, Qian; Zhang, Tian-Rui; Partike, Nancy S; Yuan, Zheng-Ping; Yu, Jin-Ming

    2015-01-01

    Background In the People’s Republic of China, both western medicine (WM) and traditional Chinese medicine (TCM) are the main treatment and rehabilitation options for cancer patients. This study aimed to explore cancer survivors’ perspectives and experience of treatment and rehabilitation, in order to promote patient-centered activities of treatment and rehabilitation. Methods Using a qualitative research approach, 68 cancer survivors were recruited from eight community cancer rehabilitation organizations in Shanghai, People’s Republic of China. Eight focus group interviews were conducted. All these interviews were transcribed verbatim, and the data were analyzed by theme analysis. Results WM was the main choice in treatment phase though study participants noted more side effects. TCM was primarily used in the recovery phase. The lack of communication between doctors and cancer patients appears to affect treatment adherence and impair the doctor–patient relationship. WM was expensive for diagnostic procedures and treatment, while the cumulative costs of frequent use of TCM in the long rehabilitation period were also high. Both treatment options created significant perceived economic burden on patients. Conflicting information about dietary supplements tended to make cancer survivors confused. Conclusion Improving the communication between doctors and cancer patients helps to ameliorate cancer patient adherence and the effect of treatments. It is essential to educate cancer patients about the effect and cost of both WM and traditional TCM. Meanwhile, marketing management and guidance to consumers regarding use of dietary supplements in the cancer rehabilitation field are also necessary. PMID:25565779

  15. A Novel Technique for Rejuvenation of Degenerated Caterpillar Medicinal Mushroom, Cordyceps militaris (Ascomycetes), a Valued Traditional Chinese Medicine.

    Science.gov (United States)

    Chen, Anhui; Wang, Yulong; Shao, Ying; Huang, Bo

    2017-01-01

    Cordyceps militaris has been used in traditional Chinese medicine for many years, but its frequent degeneration during continuous maintenance in culture can lead to substantial commercial losses. In this study, a degenerated strain of C. militaris was obtained by subculturing a wild-type strain through 10 successive subcultures. The relative abundance of the 2 mating types seems to be out of balance in the degenerated strain. By cross-mating 4 single-ascospore isolates (2 for MAT 1-1 and 2 for MAT 1-2) from the degenerated strain, we were able to restore fruiting body production to wild-type levels. The rejuvenated strain not only produced well-developed fruiting bodies but also accumulated more cordycepin and adenosine than either the original wild-type strain or the degenerated strain. These new characteristics remained stable after 4 successive transfers, which indicates that the method used to rejuvenate the degenerated strain in this study is an effective approach.

  16. Observational studies on evaluating the safety and adverse effects of traditional chinese medicine.

    Science.gov (United States)

    Lai, Jung-Nein; Tang, Jin-Ling; Wang, Jung-Der

    2013-01-01

    Background. This study aims to share our experiences when carrying out observational studies of traditional Chinese medicine (TCM). Methods. We have proactively monitored the safety profiles of Duhuo Jisheng Tang (DJT), Suan Zao Ren Tang (SZRT), and TMN-1. A list of adverse events (AEs), complete blood counts, and liver and kidney function tests were obtained from the participants during their scheduled hospital visits. Retrospective observational studies were conducted based on the reimbursement database of the National Health Insurance system, Taiwan, to explore the relationship between the use of TCM that have been adulterated by aristolochic acid and the risk from both nephrotoxins and carcinogens. Results. A total of 221, 287, and 203 AEs were detected after SZRT, DJT, and TMN-1 had been taken, respectively. Dizziness, headache, stomach ache, and diarrhea were judged to be probably related to SZRT treatment. Retrospective observational studies found an association between the consumption of aristolochic acid-containing Chinese formulae such as Mu Tong and an increased risk of CKD, ESRD, and urinary tract cancer. Conclusion. Prospective and retrospective observational studies seem to have specific advantages when investigating the safety and adverse effects of TCM therapies, as well as possibly other alternative/complementary therapies.

  17. A Review on the Traditional Chinese Medicinal Herbs and Formulae with Hypolipidemic Effect

    Directory of Open Access Journals (Sweden)

    Tung-Ting Sham

    2014-01-01

    Full Text Available Hyperlipidemia, characterized by the abnormal blood lipid profiles, is one of the dominant factors of many chronic diseases such as diabetes, obesity, and cardiovascular diseases (CVD. For the low cost, effectiveness, and fewer side effects, the popularity of using traditional Chinese medicine (TCM to handle hyperlipidemia is increasing and its role in health care has been recognized by the public at large. Despite the importance of TCM herbs and formulations, there is no comprehensive review summarizing their scientific findings on handling hyperlipidemia. This review summarizes the recent experimental and clinical results of nine representative single Chinese herbs and seven classic TCM formulae that could improve lipid profiles so as to help understand and compare their underlying mechanisms. Most of single herbs and formulae demonstrated the improvement of hyperlipidemic conditions with multiple and diverse mechanisms of actions similar to conventional Western drugs in spite of their mild side effects. Due to increasing popularity of TCM, more extensive, well-designed preclinical and clinical trials on the potential synergistic and adverse side effects of herb-drug interactions as well as their mechanisms are warranted. Hyperlipidemic patients should be warned about the potential risks of herb-drug interactions, particularly those taking anticoagulants and antiplatelet drugs.

  18. Effects of four traditional Chinese medicines on the pharmacokinetics of simvastatin.

    Science.gov (United States)

    Zhao, Qian; Jiang, Ji; Hu, Pei

    2015-01-01

    1. Concomitant traditional Chinese medicines (TCMs) could be the reason for relative poor efficacy of statins in dyslipidemia patients in China. 2. An open-label, randomized, 5-period crossover study in healthy Chinese was designed to evaluate the pharmacokinetic interaction and tolerability of multiple doses of certain TCMs on a single dose of simvastatin. In each period, subjects received one of five treatments. In Treatment A, subjects received a single dose of 20 mg simvastatin. In Treatment B, C, D or E, subjects received Tong Xin Luo, Nao Xin Tong, Guan Mai Ning or Yin Xing Ye for 7 days and a single dose of 20 mg simvastatin on Day 7. The washout period was 7 days. 3. The 97.5% confidence interval of the AUC0-48 h geometric mean ratio of simvastatin acid and simvastatin for simvastatin given after multiple oral doses of one of the TCMs versus simvastatin given alone were fully contained within the prespecified bounds of (0.50, 2.00). 4. Exposures to simvastatin acid and simvastatin following a single dose of simvastatin alone were similar to those following coadministration of a single dose of simvastatin with multiple doses of each of the TCM preparations tested. Simvastatin and these TCMs were well tolerated.

  19. Relationship between EGF, TGFA, and EGFR Gene Polymorphisms and Traditional Chinese Medicine ZHENG in Gastric Cancer

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    Junfeng Zhang

    2013-01-01

    Full Text Available In traditional Chinese medicine (TCM, correct syndrome differentiation is the most important principle guiding the prescription of Chinese herbal formulae for the treatment of gastric cancer (GC. We aimed to reveal the genetic mechanisms underlying GC syndrome differentiation (ZHENG in a population of 387 GC patients. Twenty-nine single nucleotide polymorphisms (SNPs in EGF, TGFA, and EGFR were investigated. Two SNPs, rs11466285 in TGFA and rs884225 in EGFR, were significantly associated with the distribution of ZHENG (P<0.05. The rs11466285 TT genotype increased the risk of damp heat with toxin (DHT and deficiency of both Qi and yin (DQY compared with obstruction of blood stasis (OBS. The rs884225 AA genotype could increase the risk of DQY and deficiency of both Qi and blood (DQB compared with yin deficiency due to stomach heat (YDSH. Parallel comparison among the SNPs and syndrome types revealed that DQB was distinct from YDSH, disharmony between the liver and stomach, stagnation of phlegm muddiness (SPM, OBS, and other syndromes at several SNP loci (P<0.05. The rs11466285 TT and rs884225 AA genotypes exhibit increased risk of DQB compared with OBS and SPM (P<0.05, respectively. In conclusion, the formation of GC ZHENG was related to EGF, TGFA, and EGFR gene polymorphisms.

  20. Observational Studies on Evaluating the Safety and Adverse Effects of Traditional Chinese Medicine

    Directory of Open Access Journals (Sweden)

    Jung-Nein Lai

    2013-01-01

    Full Text Available Background. This study aims to share our experiences when carrying out observational studies of traditional Chinese medicine (TCM. Methods. We have proactively monitored the safety profiles of Duhuo Jisheng Tang (DJT, Suan Zao Ren Tang (SZRT, and TMN-1. A list of adverse events (AEs, complete blood counts, and liver and kidney function tests were obtained from the participants during their scheduled hospital visits. Retrospective observational studies were conducted based on the reimbursement database of the National Health Insurance system, Taiwan, to explore the relationship between the use of TCM that have been adulterated by aristolochic acid and the risk from both nephrotoxins and carcinogens. Results. A total of 221, 287, and 203 AEs were detected after SZRT, DJT, and TMN-1 had been taken, respectively. Dizziness, headache, stomach ache, and diarrhea were judged to be probably related to SZRT treatment. Retrospective observational studies found an association between the consumption of aristolochic acid-containing Chinese formulae such as Mu Tong and an increased risk of CKD, ESRD, and urinary tract cancer. Conclusion. Prospective and retrospective observational studies seem to have specific advantages when investigating the safety and adverse effects of TCM therapies, as well as possibly other alternative/complementary therapies.

  1. Citrus flavonoids in fruit and traditional Chinese medicinal food ingredients in China.

    Science.gov (United States)

    Lu, Yanhua; Zhang, Chongwei; Bucheli, Peter; Wei, Dongzhi

    2006-06-01

    Flavonoids-enriched tissues of citrus such as peel, immature fruit and flower are consumed as culinary seasonings, tea ingredients in China for centuries. This HPLC quantitative study on the five citrus flavonoids, naringin, hesperidin, neohesperidin, sinensetin and nobiletin on a wide range of Chinese citrus fruits and several Traditional Chinese Medicinal food ingredients in East China, revealed a great diversity in flavonoid composition. Huyou peel (C. paradisi cv. Changshanhuyou) was found to be the best naringin (3.25%) and neohesperidin (2.76%) source; C. aurantium, a major ingredient of several citrus-related TCM, is also a suitable source of naringin and neohesperidin, and a good juice source for flavanone glycosides; the peel of Wenzhoumiju (C. unshiu) is one of the richest local species in hesperidin (up to 6.25%); Zaoju (C. subcompressa) has the highest content of nobiletin (0.59%), a polymethoxylated flavone. LC-ES-MS analysis of Zanthoxylum genus for flavonoids revealed for the first time the presence of significant amounts (0.74%) of hesperidin in the root of Liangmianzhen (Z. nitidum (Roxb.) DC), a relative of Sichuan pepper, which is a spice widely used in China.

  2. A Brief Introduction to Researches on Treatment of Hormone-dependent Asthma with Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    崔红生; 武维屏

    2001-01-01

    @@In recent years, with the establishment of the theory of air passage inflammation concerning the pathologic mechanism of asthma, the glucocorticoid hormone (referred to hereafter only as hormone for short), a strong inflammation killer, has become a fundamental medication for treatment of asthma. However, long period of hormone administration will result in general side effects in the whole body as well as hormone dependence, which has now become a hard problem for physicians. Now a non-hormone medication of immunosuppressant has been chosen in western medicine to treat asthma as a replacement or partial replacement of hormone. Nevertheless, its therapeutic effect is not reliable and its side effects severe, hence hardly acceptable to patients. Traditional Chinese medicine (TCM) always adheres to the principle of holistic treatment and has a great advantage in the treatment of this disease. TCM doctors have made some trials and researches in this area and obtained some accomplishments. The following is a brief account of general researches on the treatment of asthma with TCM.

  3. Traditional Chinese medicine: a treasured natural resource of anticancer drug research and development.

    Science.gov (United States)

    Wang, Chao-Yun; Bai, Xian-Yong; Wang, Chun-Hua

    2014-01-01

    To discover and develop novel natural compounds, active ingredients, single herbs and combination formulas or prescriptions in traditional Chinese medicine (TCM) with therapeutic selectivity that can preferentially kill cancer cells and inhibit the amplification of cancer without significant toxicity is an important area in cancer therapy. A lot of valuable TCMs were applied as alternative or complementary medicines in the United States and Europe. But these TCMs, as one of the main natural resources, were widely used to research and develop new drugs in Asia. In TCMs, some specific herbs, animals, minerals and combination formulas were recorded and exploited due to their active ingredients and specific natural compounds with antitumor activities. The article focused on the antitumor properties of natural compounds and combination formulas or prescriptions in TCMs, described its influence on tumor progression, angiogenesis, metastasis, and revealed its mechanisms of antitumor and inhibitory action. Among the nature compounds, triptolide, berberine, matrine, oxymatrine, kurarinone and deoxypodophyllotoxin (DPT) with specific molecular structures have been separated, purified, and evaluated their antitumor properties in vitro and in vivo. Cancer is a multifactorial and multistep disease, so the treatment effect of combination formulas and prescriptions in TCMs involving multi-targets and multi-signal pathways on tumor may be superior than that of agents targeting a single molecular target alone. Shi Quan Da Bu Tang and Yanshu injection, as well known combination formulas and prescriptions in TCMs, have shown an excellent therapeutic effect on cancer.

  4. The Effectiveness of Traditional Chinese Medicine in Treating Patients with Leukemia

    Directory of Open Access Journals (Sweden)

    Yu-Jun Wang

    2016-01-01

    Full Text Available Leukemia is the most common malignancy among all childhood cancers and is associated with a low survival rate in adult patients. Since 1995, the National Health Insurance (NHI program in Taiwan has been offering insurance coverage for Traditional Chinese Medicine (TCM, along with conventional Western medicine (WM. This study analyzes the status of TCM utilization in Taiwan, in both pediatric and adult patients with leukemia. A retrospective cohort study was conducted using population-based National Health Insurance Research Database of Registry of Catastrophic Illness, involving patient data from 2001 to 2010 and follow-up data through 2011. The effectiveness of TCM use was evaluated. Relevant sociodemographic data showed that both pediatric and adult patients who were TCM users one year prior to leukemia diagnosis were more likely to utilize TCM services for cancer therapy. A greater part of medical expenditure of TCM users was lower than that of TCM nonusers, except little discrepancy in drug fee of adult patients. The survival rate is also higher in TCM users. Altogether, these data show that TCM has the potential to serve as an adjuvant therapy when combined with conventional WM in the treatment of patients with leukemia.

  5. Application of metabolomics on diagnosis and treatment of patients with psoriasis in traditional Chinese medicine.

    Science.gov (United States)

    Lu, Chuanjian; Deng, Jingwen; Li, Li; Wang, Dongmei; Li, Guozheng

    2014-01-01

    Traditional Chinese medicine (TCM) is one of the oldest forms of medical system. With syndrome as the core of diagnosis and therapy in TCM, it has the advantage of collecting macroscopic information of patients for diagnosis. To understand the in vivo mechanism of TCM, a metabolomics approach was used to investigate the global biological characterization of the urine of psoriasis patients with Blood Stasis Syndrome and the therapeutic metabolomics mechanism of the Optimized Yinxieling formula. A total of 41 cases of psoriasis patients with Blood Stasis Syndrome and 19 healthy volunteers were enrolled in this study. Fasting urine samples from patients with consecutive Optimized Yinxieling intake after 0, 4, 8 and 12 weeks and from healthy volunteers were analyzed by Orthogonal Projection on Latent Structures Discriminant Analysis (OPLS-DA), which was utilized for High Performance Liquid Chromatography (HPLC) analysis and temporal metabolic changes identification. For psoriasis group, the scores of PASI of patients decreased after 12 weeks of Optimized Yinxieling treating. The metabolic variations visualized not only in the healthy group and psoriasis group, but also in the psoriasis group before and after Optimized Yinxieling treatment, demonstrated that the metabolic characteristics of the two groups were significantly different. The optimized complex structure of the target proteins from Protein Data Bank was analyzed by software package Discovery Studio. With docking score of original inhibitor and the receptor as the threshold values, two compounds from Chinese medicinal chemical database were predicted to have good interactions with the target proteins. The Metabolomics technique combining molecular docking analysis enhanced our current understanding of the metabolic response to Blood Stasis Syndrome of Psoriasis and the action mechanism of Optimized Yinxieling. This article is part of a Special Issue entitled: Computational Proteomics, Systems Biology

  6. Active components of common traditional Chinese medicine decoctions have antioxidant functions.

    Science.gov (United States)

    Guo, K J; Xu, S F; Yin, P; Wang, W; Song, X Z; Liu, F H; Xu, J Q; Zoccarato, I

    2011-10-01

    Many traditional Chinese medicine (TCM) decoctions are proven to have multiple functions in animal production. These decoctions are seldom recognized by the international scientific community because the mechanisms of action are not clearly elucidated. According to TCM theory, Cortex Phellodendri (COP), Rhizoma Atractylodes (RA), Agastache Rugosa (AR), and Gypsum Fibrosum (GF) can be used to formulate a medicinal compound that prevents or cures animal disease caused by heat stress. The aim of this research was to study the regulatory functions of the active components of TCM and to elucidate the effects of different TCM decoctions on antioxidant activity and lipid peroxide content, using in vitro and in vivo models of heat stress. For in vitro experiments, intestinal crypt-like epithelial cell line-6 (IEC-6) cells were employed to evaluate the effects of the active components of COP, RA, AR, and GF. For in vivo experiments, forty-eight 2-mo-old Chinese experimental mini-pigs (7.20 ± 0.02 kg) were randomly assigned to 4 groups: a normal-temperature group (NTG); a high-temperature group (HTG); HTG treated with COP, RA, AR, and GF (1:1:1:1, TCM1); and HTG treated with COP, RA, AR, and GF (1:1:1:0.5, TCM2). Results showed that the active components of the COP, RA, AR, and GF increased (P active components increased (P activities, and glutathione content, and decreased (P activities, and malondialdehyde content in porcine jejunum treated with TCM1 and TCM2 were not different (P > 0.05) from those seen in the NTG and were better (P active components of common TCM decoctions have antioxidant functions.

  7. Methodology guideline for clinical studies investigating traditional Chinese medicine and integrative medicine: executive summary.

    Science.gov (United States)

    Liu, Jian-Ping; Chen, Ke-Ji

    2015-10-01

    This guideline aims to provide a methodological guidance for clinical studies in TCM and integrative medicine in terms of study design, execution, and reporting. The commonly used methods including experimental and observational methods were introduced in this guideline such as randomized clinical trials, cohort study, case-control study, case series, and qualitative method which can be incorporated into above quantitative methods. The guideline can be used for the evaluation of therapeutic effect of TCM therapies or their combination with conventional therapy. TCM therapy refers to one of the followings or their combination: herbal medicine, acupuncture, moxibustion, cupping, Taichi/Qigong, and Guasha,Tuina (therapeutic massage). It is also suitable for research and development of ethnopharmaceuticals or folk medicine.

  8. 中医护理技术在产科的应用%Application of traditional Chinese medicine nursing technology in obstetrics

    Institute of Scientific and Technical Information of China (English)

    丁洁

    2015-01-01

    目的:探索中医护理技术的临床应用效果。方法:通过培训、沟通、宣传等实施中医护理技术,评价护理效果。结果:护理人员的中医药知识水平,中医护理操作技能显著提高,孕产妇及家属对护理服务满意度提升。结论:中医药知识技能是中医护理工作的基础,中医护理技术要发挥中医药的特色优势。%Objective:To explore the clinical application effect of traditional Chinese medicine nursing technology.Methods:The traditional Chinese medicine nursing technology was implemented through training,communication,propaganda and so on.The nursing effect was evaluated.Results:The traditional Chinese medicine knowledge level and traditional Chinese medicine nursing procedure skill of nursing personnel could be improved significantly,and the nursing service satisfaction of maternal and family were promoted.Conclusion:The traditional Chinese medicine knowledge skill is the basis of traditional Chinese medicine nursing work.Traditional Chinese medicine nursing technology should play the features and advantages of traditional Chinese medicine.

  9. Logistic Regression Analysis on Heart Diseases of Traditional Chinese Medicine%中医心病Logistic回归分析

    Institute of Scientific and Technical Information of China (English)

    宋观礼; 郭伟星; 张启明

    2011-01-01

    Objective: To offer objective data for diagnosing, preventing and treating of heart diseases in clinic. Methods: Selecting the clinical cases of the famous doctors in the archaic and modern history ofTraditional Chinese Medicine, a clinical cases databsse of Traditional Chinese Medicine was founded, Non- conditional Logistic multivariate regression was employed to screen variables stepwisely, P < 0. 05. Results: Obtaining data of the common clinicsl syndromes, pathogeneses or pathological results, symptoms and Chinese medicinal herbs of heart diseases, and the importance of the pathogeneses or pathological results, symptoms, and Chinese medicinal herbs were demonstrated quantitatively. Conclusion: According to the statistical results, attacking laws ( including the clinical syndromes and pathogeneses or pathological results ), symptom characteristics, Chinese medicinal herbs of heart diseases were summarized. From the data of Logistic regression of heart diseases,the physiological functions of heart in Traditional Chinese Medicine were also inferred and testified.%目的:为中医心病证研究提供客观的研究数据.方法:选择古代及近现代中医医家的医案,建立中医医案数据库,采用非条件Logistic多元逐步回归法筛选变量,P<0.05.结果:筛选出中医心病常见的临床证型、病因或病理结果、症状和临床用药的Logistic回归结果,并定量表述了这些病因或病理结果、症状、用药的重要性大小.结论:总结心病的发病规律(包括临床证型、病因或病理结果)、症状特点、用药规律,同时反推和证实了中医心的功能.

  10. The antiviral activity of arctigenin in traditional Chinese medicine on porcine circovirus type 2.

    Science.gov (United States)

    Chen, Jie; Li, Wentao; Jin, Erguang; He, Qigai; Yan, Weidong; Yang, Hanchun; Gong, Shiyu; Guo, Yi; Fu, Shulin; Chen, Xiabing; Ye, Shengqiang; Qian, Yunguo

    2016-06-01

    Arctigenin (ACT) is a phenylpropanoid dibenzylbutyrolactone lignan extracted from the traditional herb Arctium lappa L. (Compositae) with anti-viral and anti-inflammatory effects. Here, we investigated the antiviral activity of ACT found in traditional Chinese medicine on porcine circovirus type 2 (PCV2) in vitro and in vivo. Results showed that dosing of 15.6-62.5μg/mL ACT could significantly inhibit the PCV2 proliferation in PK-15 cells (P<0.01). Dosing of 62.5μg/mL ACT 0, 4 or 8h after challenge inoculation significantly inhibited the proliferation of 1MOI and 10MOI in PK-15 cells (P<0.01), and the inhibitory effect of ACT dosing 4h or 8h post-inoculation was greater than 0h after dosing (P<0.01). In vivo test with mice challenge against PCV2 infection demonstrated that intraperitoneal injection of 200μg/kg ACT significantly inhibited PCV2 proliferation in the lungs, spleens and inguinal lymph nodes, with an effect similar to ribavirin, demonstrating the effectiveness of ACT as an antiviral agent against PCV2 in vitro and in vivo. This compound, therefore, may have the potential to serve as a drug for protection of pigs against the infection of PCV2.

  11. Traditional Chinese medicine for prevention and treatmentof hepatocarcinoma: From bench to bedside

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    Traditional Chinese medicine (TCM) has played apositive role in the management of hepatocarcinoma.Hepatocarcinoma patients may present Qi-stagnation,damp-heat, blood stasis, Qi-deficiency, Yin-deficiency and other TCM syndromes (Zheng). Modern treatmentssuch as surgery, transarterial chemoembolization (TACE)and high intensity focus ultrasound treatment wouldinfluence the manifestation of TCM syndromes. Herbswith traditional efficacy of tonifying Qi, blood and Yin,soothing liver-Qi stagnation, clearing heat and detoxifyingand dissolving stasis, have been demonstrated to bepotent to prevent hepatocarcinogenesis. TCM hasbeen widely used in all aspects of integrative therapyin hepatocarcinoma, including surgical resection, livertransplantation, TACE, local ablative therapies and evenas monotherapy for middle-advanced stage hepatocarcinoma.Clinical practices have confirmed that TCMis effective to alleviate clinical symptoms, improvequality of life and immune function, prevent recurrenceand metastasis, delay tumor progression, and prolongsurvival time in hepatocarcinoma patients. The effectivemechanism of TCM against hepatocarcinoma is relatedto inducing apoptosis, autophagy, anoikis and cellsenescence, arresting cell cycle, regulating immunefunction, inhibiting metastasis and angiogenesis, reversingdrug resistance and enhancing effects of chemotherapy.Along with the progress of research in this field, TCMwill contribute more to the prevention and treatment ofhepatocarcinoma.

  12. Antibacterial activities, antioxidant contents and antioxidant properties of three traditional Chinese medicinal extracts

    Directory of Open Access Journals (Sweden)

    Wenbin Li

    2015-03-01

    Full Text Available The present study was carried out to identify antibacterial and antioxidant characteristics of traditional aqueous extracts derived from three traditional Chinese medicinal plants (Scutellaria baicalensis, Coptis chinensis and Sonchus oleraceus. It was indicated that the S. oleraceus showed the highest antibacterial efficacy, especially against Staphylococcus aureus. The minimum inhibitory concentration (MIC of the S. oleraceus was 5.0 mg/mL what was in correlation with the high total phenolic and flavonoid contents and CUPRAC value, and MIC of both S. baicalensis and C. chinensis was 7.5 mg/mL. The rational pH of the working S. oleraceus was acidic, while the other two preferred to neutral or alkaline environment. The reasonable preservation temperature of S. baicalensis should not beyond 60°C, while the other two below 90°C. Meanwhile, S. baicalensis had significant antioxidant activity with the highest CUPRAC and ·OH scavenging activity. These results had provided useful information on further drug discovery.

  13. Tibetan traditional medicine

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Tibetan medicine companies in T.A.R can manufacture more than 360 Tibetan patent medicines. There are 18 Tibetan medicine factories in Tibet, and total out value exceeds 3 billion yuan. 24 kinds of Tibetan patent medicines have been incorporated into State Fundamental Medicine List, in which 14 Tibetan patent medicines are listed in national protected traditional medicine category.

  14. 论中医妇产科护理%Discussion on the traditional Chinese medicine nursing of gynecology and obstetrics

    Institute of Scientific and Technical Information of China (English)

    杨冬梅

    2015-01-01

    中医特色护理是建立在中医学基本理论体系的基础上,以整体观念为指导,以辨证施护为重要依据,为病人提供身心健康的整体护理。中医护理基本内容包括:生活起居护理、用药护理、饮食护理、情志护理、康复护理、中医护理、一般护理等几个方面。文章结合实际就中医妇产科护理加以探讨,以供参考。%The Chinese characteristic nursing is the foundation of the basic theory system of TCM, and based on the concept of the whole, to provide the basis for syndrome differentiation and provide the whole nursing care for the patients with physical and mental health. The basic content of the traditional Chinese medicine nursing including: life living nursing, medicine, nursing, diet nursing, psychological care, rehabilitation care, nursing of traditional Chinese medicine, general nursing. This article explores the traditional Chinese medicine nursing of gynecology and obstetrics based on the practice ,in order to provide a reference.

  15. The symbolic context of Chinese medicine: a comparative approach to the study of traditional medical and psychiatric forms of care in Chinese culture.

    Science.gov (United States)

    Kleinman, A M

    1975-04-01

    This article explores a distinctly different aspect of Chinese medicine, and of health care in Chinese culture, from that receiving most attention and serious study at present in this country. It examines the symbolic structure and significance of illness and care in the Chinese context by (a) applying concepts developed in anthropology and the cross-cultural study of medicine and psychiatry; (b) examining recent studies of folk and popular forms of health care in contemporary Chinese communities; and (c) raising questions about the congnitive structure, cultural background, and bio-social significance of traditional Chinese healing beliefs and practices. An attempt is made to place this analysis in a comparative framework, so that Chinese cases can be related to health care systems in other cultural settings.

  16. Effects of combined therapy of traditional Chinese medicine and western medicine on platelets, coagulative functions and inflammatory cytokines with ulcerative colitis

    Institute of Scientific and Technical Information of China (English)

    Yun-Xia Lei; Lei He; Hao Sheng; Xin Liu

    2016-01-01

    Objective:To explore the effects of combined therapy of traditional Chinese medicine and western medicine on platelets, coagulative functions and inflammatory cytokines in patients with ulcerative colitis (UC). Methods:A total of 267 patients with UC were collected. 137 patients were treated with combined therapy of traditional Chinese medicine and western medicine as experimental group and 130 patients were treated with only western medicine as controls. Platelet count, coagulation function indexes and inflammatory cytokines were measured before and 15 d after the treatment. Results:No significantly differences were found in all indexes before treatment between two groups. After different treatments, platelet count (PLT), platelet distribution width (PDW) were significantly decreased in both groups, but mean platelet volumn (MPV) were significantly increased than before treatment. PLT and PDW were significantly lower and MPV were significantly higher in experimental group than control group. Fibrinogen (Fib) and D-dimer (DD) decreased significantly after treatment. Fib and DD in experimental group were significantly lower than controls. No significantly differences were found in activated partial thromboplastin time (APTT) and prothrobin time (PT). Tumor necrosisi factor-α(TNF-α), interleukin-6 (IL-6) and interleukin-8 (IL-8) decreased significantly in both group after treatment. TNF-α, IL-6 and IL-8 were significantly lower in experimental group than controls. Conclusion:Combined therapy of traditional Chinese medicine and western medicine can more effectively improve the cogulation, fibrinolysis and inflammation in patients with UC than only western medicine therapy.

  17. Anti-Inflammatory Effects of 81 Chinese Herb Extracts and Their Correlation with the Characteristics of Traditional Chinese Medicine

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    Chang-Liang Chen

    2014-01-01

    Full Text Available Inducible nitrogen oxide synthase (iNOS is the primary contributor of the overproduction of nitric oxide and its inhibitors have been actively sought as effective anti-inflammatory agents. In this study, we prepared 70% ethanol extracts from 81 Chinese herbs. These extracts were subsequently evaluated for their effect on nitrogen oxide (NO production and cell growth in LPS/IFNγ-costimulated and unstimulated murine macrophage RAW264.7 cells by Griess reaction and MTT assay. Extracts of Daphne genkwa Sieb.et Zucc, Caesalpinia sappan L., Iles pubescens Hook.et Arn, Forsythia suspensa (Thunb. Vahl, Zingiber officinale Rosc, Inula japonica Thunb., and Ligusticum chuanxiong Hort markedly inhibited NO production (inhibition > 90% at 100 μg/mL. Among active extracts (inhibition > 50% at 100 μg/mL, Rubia cordifolia L., Glycyrrhiza glabra L., Iles pubescens Hook.et Arn, Nigella glandulifera Freyn et Sint, Pueraria lobata (Willd. Ohwi, and Scutellaria barbata D. Don displayed no cytotoxicity to unstimulated RAW246.7 cells while increasing the growth of LPS/IFNγ-costimulated cells. By analyzing the correlation between their activities and their Traditional Chinese Medicine (TCM characteristics, herbs with pungent flavor displayed potent anti-inflammatory capability. Our study provides a series of potential anti-inflammatory herbs and suggests that herbs with pungent flavor are candidates of effective anti-inflammatory agents.

  18. Anti-inflammatory effects of 81 chinese herb extracts and their correlation with the characteristics of traditional chinese medicine.

    Science.gov (United States)

    Chen, Chang-Liang; Zhang, Dan-Dan

    2014-01-01

    Inducible nitrogen oxide synthase (iNOS) is the primary contributor of the overproduction of nitric oxide and its inhibitors have been actively sought as effective anti-inflammatory agents. In this study, we prepared 70% ethanol extracts from 81 Chinese herbs. These extracts were subsequently evaluated for their effect on nitrogen oxide (NO) production and cell growth in LPS/IFNγ-costimulated and unstimulated murine macrophage RAW264.7 cells by Griess reaction and MTT assay. Extracts of Daphne genkwa Sieb.et Zucc, Caesalpinia sappan L., Iles pubescens Hook.et Arn, Forsythia suspensa (Thunb.) Vahl, Zingiber officinale Rosc, Inula japonica Thunb., and Ligusticum chuanxiong Hort markedly inhibited NO production (inhibition > 90% at 100 μg/mL). Among active extracts (inhibition > 50% at 100 μg/mL), Rubia cordifolia L., Glycyrrhiza glabra L., Iles pubescens Hook.et Arn, Nigella glandulifera Freyn et Sint, Pueraria lobata (Willd.) Ohwi, and Scutellaria barbata D. Don displayed no cytotoxicity to unstimulated RAW246.7 cells while increasing the growth of LPS/IFNγ-costimulated cells. By analyzing the correlation between their activities and their Traditional Chinese Medicine (TCM) characteristics, herbs with pungent flavor displayed potent anti-inflammatory capability. Our study provides a series of potential anti-inflammatory herbs and suggests that herbs with pungent flavor are candidates of effective anti-inflammatory agents.

  19. On Integration of Traditional Chinese Medicine and Western Medicine from the Perspective of Syncretism%融贯论视域下的中西医结合

    Institute of Scientific and Technical Information of China (English)

    马家忠; 张洪雷

    2012-01-01

    融贯论是对中医整体综合方法和西医分析还原方法的扬弃,是一种适合于中西医结合的方法论.在融贯论的视域下,中西医结合必须坚持时间结构和空间结构相统一、整体综合和分析还原相融合、随机治疗和规范治疗相补充、实践行动和认识理解相配合,才能更好地促进中西医结合医学的发展.%Syncretism is the sublation of Traditional Chinese Medicine macroscopic integration and Western Medicine micro-analysis, and it is a kind of methodology suiting for integrated Traditional Chinese and Western Medicine. From the angle of Syncretism, integrated Traditional Chinese and Western Medicine has to persist in the unification of time structure and space structure, the fusion of macroscopic integration and micro-analysis, the supplement of random cure and standard cure, the combination of cognition and practice. Only in the way can we promote the development of integrated Traditional Chinese and Western Medicine.

  20. Lead Screening for Chronic Obstructive Pulmonary Disease of IKK2 Inhibited by Traditional Chinese Medicine

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    Yung-An Tsou

    2014-01-01

    Full Text Available Chronic obstructive pulmonary disease (COPD is a chronic obstructive lung disease and is frequently found in well-developed countries due to the issue of aging populations. Not all forms of medical treatment are unable to return a patient's limited pulmonary function back to normal and eventually they could require a lung transplant. At this time, COPD is the leading cause of death in the world. Studies surveying I-kappa-B-kinase beta (IKK2 are very relevant to the occurrence and deterioration of the condition COPD. The sinapic acid-4-O-sulfate, kaempferol, and alpha-terpineol were found to be IKK2 inhibitors and helped prevent COPD occurrence and worsening according to a screening of the traditional Chinese medicine (TCM database. The protein-ligand interaction of these three compounds with regard to IKK2 was also done by molecular dynamics. The docking poses, hydrogen bond variation, and hydrophobic interactions found Asp103 and Lys106 are crucial to IKK2 binding areas for IKK2 inhibition. Finally, we found the three compounds that have an equally strong effect in terms of IKK2 binding proven by the TCM database and perhaps these may be an alternative treatment for COPD in the future.

  1. In silico investigation of potential SRC kinase ligands from traditional Chinese medicine.

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    Weng Ieong Tou

    Full Text Available Src kinase is an attractive target for drug development based on its established relationship with cancer and possible link to hypertension. The suitability of traditional Chinese medicine (TCM compounds as potential drug ligands for further biological evaluation was investigated using structure-based, ligand-based, and molecular dynamics (MD analysis. Isopraeroside IV, 9alpha-hydroxyfraxinellone-9-O-beta-D-glucoside (9HFG and aurantiamide were the top three TCM candidates identified from docking. Hydrogen bonds and hydrophobic interactions were the primary forces governing docking stability. Their stability with Src kinase under a dynamic state was further validated through MD and torsion angle analysis. Complexes formed by TCM candidates have lower total energy estimates than the control Sacaratinib. Four quantitative-structural activity relationship (QSAR in silico verifications consistently suggested that the TCM candidates have bioactive properties. Docking conformations of 9HFG and aurantiamide in the Src kinase ATP binding site suggest potential inhibitor-like characteristics, including competitive binding at the ATP binding site (Lys295 and stabilization of the catalytic cleft integrity. The TCM candidates have significantly lower ligand internal energies and are estimated to form more stable complexes with Src kinase than Saracatinib. Structure-based and ligand-based analysis support the drug-like potential of 9HFG and aurantiamide and binding mechanisms reveal the tendency of these two candidates to compete for the ATP binding site.

  2. A Non-Contact Pulse Automatic Positioning Measurement System for Traditional Chinese Medicine

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    Ying-Yun Chen

    2015-04-01

    Full Text Available This study is to construct a non-contact pulse automatic positioning measurement system for Traditional Chinese Medicine (TCM using optical triangulation measurements. The system consists of a linear laser, a CMOS image sensor and image analysis software. The linear laser is projected on the pulse beat location on the wrists; the CMOS image sensor records the process and the software analyzes the images. The program mainly uses the optical centroid and fast Fourier transform (FFT principles to calculate centroid changes (pulse amplitude changes from the images taken by the CMOS image sensor. It returns the positions of cun, guan and chi pulses automatically in terms of the amplitudes and the signals are then transformed from the time domain (time-amplitude into the frequency domain (frequency-amplitude via FFT to obtain the waveforms and frequencies of the cun, guan and chi pulses. It successfully extracts the data from the TCM pulse reading and can be a medical aid system for TCM. Combining the advantages of optical measurement and computer automation, this system provides a non-contact, easy to operate, fast in detection and low-cost equipment design.

  3. Exploring the Ligand-Protein Networks in Traditional Chinese Medicine: Current Databases, Methods, and Applications

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    Mingzhu Zhao

    2013-01-01

    Full Text Available The traditional Chinese medicine (TCM, which has thousands of years of clinical application among China and other Asian countries, is the pioneer of the “multicomponent-multitarget” and network pharmacology. Although there is no doubt of the efficacy, it is difficult to elucidate convincing underlying mechanism of TCM due to its complex composition and unclear pharmacology. The use of ligand-protein networks has been gaining significant value in the history of drug discovery while its application in TCM is still in its early stage. This paper firstly surveys TCM databases for virtual screening that have been greatly expanded in size and data diversity in recent years. On that basis, different screening methods and strategies for identifying active ingredients and targets of TCM are outlined based on the amount of network information available, both on sides of ligand bioactivity and the protein structures. Furthermore, applications of successful in silico target identification attempts are discussed in detail along with experiments in exploring the ligand-protein networks of TCM. Finally, it will be concluded that the prospective application of ligand-protein networks can be used not only to predict protein targets of a small molecule, but also to explore the mode of action of TCM.

  4. In silico identification of potent pancreatic triacylglycerol lipase inhibitors from traditional Chinese medicine.

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    Kuan-Yu Chen

    Full Text Available Pancreatic triacylglycerol lipase (PNLIP are primary lipases that are critical for triacylglyceride digestion in human. Since reduced metabolism of triacylglyceride might be a plausible concept for weight loss, we screened for potential PNLIP inhibitors from traditional Chinese medicine (TCM with the aim to identify weight loss candidate compounds. TCM candidates Aurantiamide, Cnidiadin, and 2-hexadecenoic acid exhibited higher Dock Scores than the commercial drug Orlistat, and were also predicted to have inhibitory characteristics against PNLIP using constructed MLR (R(2 = 0.8664 and SVM (R(2 = 0.9030 models. Molecular dynamics indicated that the TCM-PNLIP complexes formed were stable. We identified that the PNLIP binding site has several residues that can serve as anchors, and a hydrophobic corridor that provides additional stability to the complex. Aurantiamide, Cnidiadin, and 2-hexadecenoic acid all have features that correspond to these binding site features, indicating their potential as candidates for PNLIP inhibitors. The information presented in this study may provide helpful insights to designing novel weight-control drugs.

  5. In silico identification of anti-cancer compounds and plants from traditional Chinese medicine database

    Science.gov (United States)

    Dai, Shao-Xing; Li, Wen-Xing; Han, Fei-Fei; Guo, Yi-Cheng; Zheng, Jun-Juan; Liu, Jia-Qian; Wang, Qian; Gao, Yue-Dong; Li, Gong-Hua; Huang, Jing-Fei

    2016-05-01

    There is a constant demand to develop new, effective, and affordable anti-cancer drugs. The traditional Chinese medicine (TCM) is a valuable and alternative resource for identifying novel anti-cancer agents. In this study, we aim to identify the anti-cancer compounds and plants from the TCM database by using cheminformatics. We first predicted 5278 anti-cancer compounds from TCM database. The top 346 compounds were highly potent active in the 60 cell lines test. Similarity analysis revealed that 75% of the 5278 compounds are highly similar to the approved anti-cancer drugs. Based on the predicted anti-cancer compounds, we identified 57 anti-cancer plants by activity enrichment. The identified plants are widely distributed in 46 genera and 28 families, which broadens the scope of the anti-cancer drug screening. Finally, we constructed a network of predicted anti-cancer plants and approved drugs based on the above results. The network highlighted the supportive role of the predicted plant in the development of anti-cancer drug and suggested different molecular anti-cancer mechanisms of the plants. Our study suggests that the predicted compounds and plants from TCM database offer an attractive starting point and a broader scope to mine for potential anti-cancer agents.

  6. Effects of traditional Chinese medicine on intestinal mucosal permeability in early phase of severe acute pancreatitis

    Institute of Scientific and Technical Information of China (English)

    CHEN Hong; LI Fei; JIA Jian-guo; DIAO Yong-peng; LI Zong-xin; SUN Jia-bang

    2010-01-01

    Background Traditional Chinese medicine has been used widely for many years in China to treat acute pancreatitis.We have investigated the effects of Dachengqi decoction on intestinal mucosal permeability and outcome in patients with severe acute pancreatitis (SAP).Methods Forty patients with sustained SAP that required admission to the surgical intensive care unit were enrolled prospectively in the study. All of these patients were divided randomly into the Dachengqi decoction group (n=20) and control group (n=20) on admission. Intestinal permeability was assessed by measuring absorption of two metabolically inert markers, lactulose (L) and mannitol (M), which were administered orally. Serum concentrations of endotoxin (lipopolysaccharide, LPS) and the ratio of lactulose to mannitol in urine (L/M) were detected in all patients.Results Compared with those in the control group, urinary L/M ratio decreased significantly in the Dachengqi decoction group on the 7th day after admission (P=0.001). Also, serum concentrations of LPS were reduced on the 5th and 7th day after admission (P=0.006, P=0.008, respectively). Incidence of multiple organ dysfunction syndrome (MODS) and pancreatic infection was significantly lower in the Dachengqi decoction group compared with those in the control group (P=0.038, P=0.025, respectively).Conclusion Dachengqi decoction may promote the recovery of intestinal mucosal permeability and decrease the incidence of MODS and pancreatic infection in patients with SAP.

  7. Application methods of infrared thermal images in the health care field of traditional Chinese medicine

    Science.gov (United States)

    Li, Ziru; Zhang, Xusheng

    2008-12-01

    Infrared thermal imaging (ITI) is the potential imaging technique for the health care field of traditional Chinese medicine (TCM). Successful application demands obeying the characteristics and regularity of the ITI of human body and designing rigorous trials. First, the influence of time must be taken into account as the ITI of human body varies with time markedly. Second, relative magnitude is preferred to be the index of the image features. Third, scatter diagrams and the method of least square could present important information for evaluating the health care effect. A double-blind placebo-controlled randomized trial was undertaken to study the influences of Shengsheng capsule, one of the TCM health food with immunity adjustment function, on the ITI of human body. The results showed that the effect of Shengsheng capsule to people with weak constitution or in the period of being weak could be reflected objectively by ITI. The relative efficacy rate was 81.3% for the trial group and 30.0% for the control group, there was significant difference between the two groups (P=0.003). So the sensitivity and objectivity of ITI are of great importance to the health care field of TCM.

  8. Design of Glucagon-Like Peptide-1 Receptor Agonist for Diabetes Mellitus from Traditional Chinese Medicine

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    Hsin-Chieh Tang

    2014-01-01

    Full Text Available Glucagon-like peptide-1 (GLP-1 is a promising target for diabetes mellitus (DM therapy and reduces the occurrence of diabetes due to obesity. However, GLP-1 will be hydrolyzed soon by the enzyme dipeptidyl peptidase-4 (DPP-4. We tried to design small molecular drugs for GLP-1 receptor agonist from the world's largest traditional Chinese medicine (TCM Database@Taiwan. According to docking results of virtual screening, we selected 2 TCM compounds, wenyujinoside and 28-deglucosylchikusetsusaponin IV, for further molecular dynamics (MD simulation. GLP-1 was assigned as the control compound. Based on the results of root mean square deviation (RMSD, solvent accessible surface (SAS, mean square deviation (MSD, Gyrate, total energy, root mean square fluctuation (RMSF, matrices of smallest distance of residues, database of secondary structure assignment (DSSP, cluster analysis, and distance of H-bond, we concluded that all the 3 compounds could bind and activate GLP-1 receptor by computational simulation. Wenyujinoside and 28-deglucosylchikusetsusaponin IV were the TCM compounds that could be GLP-1 receptor agonists.

  9. [Binding mechanism of traditional Chinese medicine active component 5-hydroxymethyl-furfural and HSA or BSA].

    Science.gov (United States)

    Guo, Ming; He, Ling; Lu, Xiao-Wang

    2012-03-01

    A combination of spectral experiment and molecular modeling techniques has been used to characterize the binding mechanism between an active component 5-hydroxymethyl-furfural (5-HMF) of traditional Chinese medicine and human serum albumin (HSA) or bovine serum albumin (BSA). The interaction mechanism of 5-HMF binding with HSA/BSA is analyzed. Although the drug can bind with HSA/BSA to form stable complexes, there are some differences in the bond strength. The values of binding distances (r) are different and low, which indicated the occurrence of energy transfer. The drug had conformational effect on HSA/BSA, which resulted in different changes of hydrophobic environment of the binding domain in HSA/BSA. The 'phase diagram' of fluorescence revealed that the changes on the conformational pattern of proteins have been affected by drug conformed to the "all-or-none" pattern. The interactions between drug and protein influenced by Co(II) were also discussed. Its effects acting on 5-HMF-HSA/BSA interactions are different. The computational modeling method was used to study the interaction between 5-HMF and HSA/BSA. The results of molecular model studies revealed that the binding modes for drug-serum albumin systems are mainly hydrophobic interactions and hydrogen bonding. These results are in accordance with spectral results. The research results have given a better theoretical reference for the study of pharmacological mechanism of 5-hydroxymethyl-furfural.

  10. Treatment of Chinese traditional medicine wastewater in a submerged membrane bioreactor

    Institute of Scientific and Technical Information of China (English)

    REN Nan-qi; CHEN Zhao-bo; ZHANG Ying; HU Dong-xue

    2007-01-01

    A pilot scale test was conducted in a submerged membrane bioreactor SMBR with capacity of 10.0 m3/d for 120 days to treat high-strength Chinese traditional medicine wastewater. Performance of the SMBR was investigated with a sludge retention time ( TSR ) of 50 days, a hydraulic retention time ( THR ) of 8. 0 h, membrane flux of 8. 0 L/( m2 · h) and dissolved oxygen (DO) concentration of 2.0 - 3.0 mg/L, respectively. It was observed that the SMBR had high capacity of COD and suspended solid (SS) removal. The influent COD concentration was fluctuated between 1 000 and 5 000 mg/L, while the averaged effluent COD concentration was only 44.6 mg/L. The influent SS concentration was fluctuated between 1 000 and 1 600 mg/L, while little effluent SS was detected. It was found that the COD remove rate increased with mixed liquor suspended solids (MLSS) and organic loading rate (ROL). In order to obtain good-quality effluent, the operational conditions of the SMBR were suggested as follows: the temperature was controlled above 10 ℃, MLSS about 7000 mg/L, ROL under 24. 76 kg/( m3 · d) , low vacuum value and constant water flux.

  11. Entropy-Based Model for Interpreting Life Systems in Traditional Chinese Medicine

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    Guo-lian Kang

    2008-01-01

    Full Text Available Traditional Chinese medicine (TCM treats qi as the core of the human life systems. Starting with a hypothetical correlation between TCM qi and the entropy theory, we address in this article a holistic model for evaluating and unveiling the rule of TCM life systems. Several new concepts such as acquired life entropy (ALE, acquired life entropy flow (ALEF and acquired life entropy production (ALEP are propounded to interpret TCM life systems. Using the entropy theory, mathematical models are established for ALE, ALEF and ALEP, which reflect the evolution of life systems. Some criteria are given on physiological activities and pathological changes of the body in different stages of life. Moreover, a real data-based simulation shows life entropies of the human body with different ages, Cold and Hot constitutions and in different seasons in North China are coincided with the manifestations of qi as well as the life evolution in TCM descriptions. Especially, based on the comparative and quantitative analysis, the entropy-based model can nicely describe the evolution of life entropies in Cold and Hot individuals thereby fitting the Yin–Yang theory in TCM. Thus, this work establishes a novel approach to interpret the fundamental principles in TCM, and provides an alternative understanding for the complex life systems.

  12. [Application of uncertainty assessment in NIR quantitative analysis of traditional Chinese medicine].

    Science.gov (United States)

    Xue, Zhong; Xu, Bing; Liu, Qian; Shi, Xin-Yuan; Li, Jian-Yu; Wu, Zhi-Sheng; Qiao, Yan-Jiang

    2014-10-01

    The near infrared (NIR) spectra of Liuyi San samples were collected during the mixing process and the quantitative models by PLS (partial least squares) method were generated for the quantification of the concentration of glycyrrhizin. The PLS quantitative model had good calibration and prediction performances (r(cal) 0.998 5, RMSEC = 0.044 mg · g(-1); r(val) = 0.947 4, RMSEP = 0.124 mg · g(-1)), indicating that NIR spectroscopy can be used as a rapid determination method of the concentration of glycyrrhizin in Liuyi San powder. After the validation tests were designed, the Liao-Lin-Iyer approach based on Monte Carlo simulation was used to estimate β-content-γ-confidence tolerance intervals. Then the uncertainty was calculated, and the uncer- tainty profile was drawn. The NIR analytical method was considered valid when the concentration of glycyrrhizin is above 1.56 mg · g(-1) since the uncertainty fell within the acceptable limits (λ = ± 20%). The results showed that uncertainty assessment can be used in NIR quantitative models of glycyrrhizin for different concentrations and provided references for other traditional Chinese medicine to finish the uncertainty assessment using NIR quantitative analysis.

  13. The Quintessence of Traditional Chinese Medicine: Syndrome and Its Distribution among Advanced Cancer Patients with Constipation

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    Chung-Wah Cheng

    2012-01-01

    Full Text Available Constipation is a common problem in advanced cancer patients; however, specific clinical guidelines on traditional Chinese medicine (TCM syndrome (Zhang are not yet available. In this cross-sectional study, the TCM syndromes distribution and their common symptoms and signs among 225 constipated advanced cancer patients were determined. Results showed that 127 patients (56.4% and 7 patients (3.1% were in deficient and excessive patterns, respectively, while 91 patients (40.4% were in deficiency-excess complex. The distributions of the five syndromes were: Qi deficiency (93.3%, Qi stagnation (40.0%, blood (Yin deficiency (28.9%, Yang deficiency (22.2%, and excess heat (5.8%. Furthermore, age, functional status, and level of blood haemoglobin were factors related to the type of TCM syndrome. A TCM prescription with the functions on replenishing the Deficiency, redirecting the flow of Qi stagnation and moistening the dryness caused by the blood (Yin deficiency can be made for the treatment of advance cancer patients with constipation. Robust trials are urgently needed for further justifying its efficacy and safety in evidence-based approaches.

  14. Cerebral Activity Changes in Different Traditional Chinese Medicine Patterns of Psychogenic Erectile Dysfunction Patients

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    Qi Liu

    2015-01-01

    Full Text Available Background. Pattern differentiation is the foundation of traditional Chinese medicine (TCM treatment for erectile dysfunction (ED. This study aims to investigate the differences in cerebral activity in ED patients with different TCM patterns. Methods. 27 psychogenic ED patients and 27 healthy subjects (HS were enrolled in this study. Each participant underwent an fMRI scan in resting state. The fractional amplitude of low-frequency fluctuation (fALFF was used to detect the brain activity changes in ED patients with different patterns. Results. Compared to HS, ED patients showed an increased cerebral activity in bilateral cerebellum, insula, globus pallidus, parahippocampal gyrus, orbitofrontal cortex (OFC, and middle cingulate cortex (MCC. Compared to the patients with liver-qi stagnation and spleen deficiency pattern (LSSDP, the patients with kidney-yang deficiency pattern (KDP showed an increased activity in bilateral brainstem, cerebellum, hippocampus, and the right insula, thalamus, MCC, and a decreased activity in bilateral putamen, medial frontal gyrus, temporal pole, and the right caudate nucleus, OFC, anterior cingulate cortex, and posterior cingulate cortex (P<0.005. Conclusions. The ED patients with different TCM patterns showed different brain activities. The differences in cerebral activity between LSSDP and KDP were mainly in the emotion-related regions, including prefrontal cortex and cingulated cortex.

  15. Computational design of apolipoprotein E4 inhibitors for Alzheimer's disease therapy from traditional Chinese medicine.

    Science.gov (United States)

    Huang, Hung-Jin; Chen, Hsin-Yi; Lee, Cheng-Chun; Chen, Calvin Yu-Chian

    2014-01-01

    Apolipoprotein E4 (Apo E4) is the major genetic risk factor in the causation of Alzheimer's disease (AD). In this study we utilize virtual screening of the world's largest traditional Chinese medicine (TCM) database and investigate potential compounds for the inhibition of ApoE4. We present the top three TCM candidates: Solapalmitine, Isodesacetyluvaricin, and Budmunchiamine L5 for further investigation. Dynamics analysis and molecular dynamics (MD) simulation were used to simulate protein-ligand complexes for observing the interactions and protein variations. Budmunchiamine L5 did not have the highest score from virtual screening; however, the dynamics pose is similar to the initial docking pose after MD simulation. Trajectory analysis reveals that Budmunchiamine L5 was stable over all simulation times. The migration distance of Budmunchiamine L5 illustrates that docked ligands are not variable from the initial docked site. Interestingly, Arg158 was observed to form H-bonds with Budmunchiamine L5 in the docking pose and MD snapshot, which indicates that the TCM compounds could stably bind to ApoE4. Our results show that Budmunchiamine L5 has good absorption, blood brain barrier (BBB) penetration, and less toxicity according to absorption, distribution, metabolism, excretion, and toxicity (ADMET) prediction and could, therefore, be safely used for developing novel ApoE4 inhibitors.

  16. BATMAN-TCM: a Bioinformatics Analysis Tool for Molecular mechANism of Traditional Chinese Medicine

    Science.gov (United States)

    Liu, Zhongyang; Guo, Feifei; Wang, Yong; Li, Chun; Zhang, Xinlei; Li, Honglei; Diao, Lihong; Gu, Jiangyong; Wang, Wei; Li, Dong; He, Fuchu

    2016-01-01

    Traditional Chinese Medicine (TCM), with a history of thousands of years of clinical practice, is gaining more and more attention and application worldwide. And TCM-based new drug development, especially for the treatment of complex diseases is promising. However, owing to the TCM’s diverse ingredients and their complex interaction with human body, it is still quite difficult to uncover its molecular mechanism, which greatly hinders the TCM modernization and internationalization. Here we developed the first online Bioinformatics Analysis Tool for Molecular mechANism of TCM (BATMAN-TCM). Its main functions include 1) TCM ingredients’ target prediction; 2) functional analyses of targets including biological pathway, Gene Ontology functional term and disease enrichment analyses; 3) the visualization of ingredient-target-pathway/disease association network and KEGG biological pathway with highlighted targets; 4) comparison analysis of multiple TCMs. Finally, we applied BATMAN-TCM to Qishen Yiqi dripping Pill (QSYQ) and combined with subsequent experimental validation to reveal the functions of renin-angiotensin system responsible for QSYQ’s cardioprotective effects for the first time. BATMAN-TCM will contribute to the understanding of the “multi-component, multi-target and multi-pathway” combinational therapeutic mechanism of TCM, and provide valuable clues for subsequent experimental validation, accelerating the elucidation of TCM’s molecular mechanism. BATMAN-TCM is available at http://bionet.ncpsb.org/batman-tcm. PMID:26879404

  17. Validation of a Novel Traditional Chinese Medicine Pulse Diagnostic Model Using an Artificial Neural Network

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    Anson Chui Yan Tang

    2012-01-01

    Full Text Available In view of lacking a quantifiable traditional Chinese medicine (TCM pulse diagnostic model, a novel TCM pulse diagnostic model was introduced to quantify the pulse diagnosis. Content validation was performed with a panel of TCM doctors. Criterion validation was tested with essential hypertension. The gold standard was brachial blood pressure measured by a sphygmomanometer. Two hundred and sixty subjects were recruited (139 in the normotensive group and 121 in the hypertensive group. A TCM doctor palpated pulses at left and right cun, guan, and chi points, and quantified pulse qualities according to eight elements (depth, rate, regularity, width, length, smoothness, stiffness, and strength on a visual analog scale. An artificial neural network was used to develop a pulse diagnostic model differentiating essential hypertension from normotension. Accuracy, specificity, and sensitivity were compared among various diagnostic models. About 80% accuracy was attained among all models. Their specificity and sensitivity varied, ranging from 70% to nearly 90%. It suggested that the novel TCM pulse diagnostic model was valid in terms of its content and diagnostic ability.

  18. Doctor-Shopping Behaviors among Traditional Chinese Medicine Users in Taiwan.

    Science.gov (United States)

    Lin, Ming-Hwai; Chang, Hsiao-Ting; Tu, Chun-Yi; Chen, Tzeng-Ji; Hwang, Shinn-Jang

    2015-08-07

    Doctor-shopping has caused an increase in medical expense, potential to receive duplicate medications, and suffer adverse drug reactions. We carried out a population-based retrospective study aimed at examining the user patterns of traditional Chinese medicine (TCM) ambulatory care in Taiwan. We retrieved complete TCM ambulatory visit datasets for the year 2007 from the National Health Insurance database in Taiwan. We defined the patients whose distribution of TCM physician numbers scored more than 97.5 percent (more than, or equal to, five TCM physicians) within one year as TCM doctor-shoppers. In total, 6,596,814 subjects (28.9%) paid TCM visits during that year. All 177,728 subjects (2.69%) who visited more than five (including) TCM physicians were classified as TCM shoppers. The most prevalent diagnostic grouping was upper respiratory infections (44.7%) and sprains and strains (44.0%). Men had a lower odds ratio (OR) among TCM shoppers than women (OR = 0.94, 95% confidence interval (CI) = 0.93-0.96). Younger people were less likely to be TCM shoppers than other people were. The ORs of TCM shoppers were higher among veterans and low-income patients (OR = 1.29 (1.23-1.35), and 1.33 (1.27-1.41)). In conclusion, health education on the potential of drug interactions and iatrogenic health risks incurred from doctor-shopping should be addressed to those high-risk patients.

  19. In Silico Design of BACE1 Inhibitor for Alzheimer’s Disease by Traditional Chinese Medicine

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    Hung-Jin Huang

    2014-01-01

    Full Text Available The β-site APP cleaving enzyme 1 (BACE1 is an important target for causing Alzheimer’s disease (AD, due to the brain deposition peptide amyloid beta (Aβ require cleavages of amyloid precursor protein (APP by BACE1 and γ-secretase, but treatments of AD still have side effect in recent therapy. This study utilizes the world largest traditional Chinese medicine (TCM database and database screening to provide potential BACE1 inhibited compound. Molecular dynamics (MD simulation was carried out to observe the dynamics structure after ligand binding. We found that Triptofordin B1 has less toxicity than pyrimidine analogue, which has more potent binding affinity with BACE1. For trajectory analysis, all conformations are tending to be stable during 5000 ps simulation time. In dynamic protein validation, the residues of binding region are still stable after MD simulation. For snapshot comparison, we found that Triptofordin B1 could reduce the binding cavity; the results reveal that Triptofordin B1 could bind to BACE1 and better than control, which could be used as potential lead drug to design novel BACE1 inhibitor for AD therapy.

  20. Beneficial Effects and Safety of Corticosteroids Combined with Traditional Chinese Medicine for Pemphigus: A Systematic Review

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    Tingting Zhou

    2015-01-01

    Full Text Available Objective. To evaluate the beneficial effects and safety of corticosteroids combined with traditional Chinese medicine (TCM for pemphigus. Methods. Seven electronic databases were searched to identify any potential randomized controlled trials (RCTs or clinical controlled trials (CCTs that compared corticosteroids with and without TCM for the treatment of pemphigus, published in any language. Remission of the mucocutaneous lesions, therapeutic duration, dosage of corticosteroids, and specific antibody titers were employed as the main outcome measures. The methodological quality of the included studies was assessed using the Cochrane Handbook for Systematic Review of Interventions and Rev Man 5.1.0 software. Results. Four RCTs with a total of 199 patients were included in the present review. Management with corticosteroids combined with TCM seemed to benefit pemphigus patients in terms of healing of lesions, prevention of complications and relapse, and reduced interferon-gamma (IFN-γ level. The trials were not of high methodological quality. No study mentioned allocation concealment and blinding. Only one trial reported adverse events, and it indicated that the safety of corticosteroids combined with TCM was uncertain. Conclusion. There is some, albeit weak, evidence to show that combined treatment with corticosteroids with TCM could be of benefit for some patients with pemphigus. The efficacy and safety of this combined treatment should be evaluated further in better designed, fully powered, and confirmatory RCTs.

  1. Diabetic Osteoporosis: A Review of Its Traditional Chinese Medicinal Use and Clinical and Preclinical Research

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    Rufeng Ma

    2016-01-01

    Full Text Available Aim. The incidence of diabetic osteoporosis (DOP is increasing due to lack of effective management over the past few decades. This review aims to summarize traditional Chinese medicine (TCM suitability in the pathogenesis and clinical and preclinical management of DOP. Methods. Literature sources used were from Medline (Pubmed, CNKI (China Knowledge Resource Integrated Database, and CSTJ (China Science and Technology Journal Database online databases. For the consultation, keywords such as diabetic osteoporosis (DOP, TCM, clinical study, animal experiment, toxicity, and research progress were used in various combinations. Around 100 research papers and reviews were visited. Results. Liver-spleen-kidney insufficiency may result in development of DOP. 18 clinical trials are identified to use TCM compound prescriptions for management of patients with DOP. TCM herbs and their active ingredients are effective in preventing the development of DOP in streptozotocin (STZ and alloxan as well as STZ combined with ovariectomy insulted rats. Among them, most frequently used TCM herbs in clinical trials are Radix Astragali, Radix et Rhizoma Salviae Miltiorrhizae, Radix Rehmanniae Preparata, and Herba Epimedii. Some of TCM herbs also exhibit toxicities in clinical and preclinical research. Conclusions. TCM herbs may act as the novel sources of anti-DOP drugs by improving bone and glucolipid metabolisms. However, the pathogenesis of DOP and the material base of TCM herbs still merit further study.

  2. Patterns of Traditional Chinese Medicine Diagnosis in Thermal Laser Acupuncture Treatment of Knee Osteoarthritis

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    Lizhen Wang

    2013-01-01

    Full Text Available Knee osteoarthritis (OA manifests with pain, joint stiffness, and limited function. In traditional Chinese medicine, knee OA is differentiated into three patterns: yang deficiency and cold coagulation, kidney deficiency, and blood stasis. The objective of this study was to determine whether yang deficiency cold coagulation patients respond better to thermal laser acupuncture treatment than do non-yang deficient patients. Fifty-two patients with OA were allocated to group A (yang deficient, n=26 or B (non-yang deficient, n=26. All patients received a 20-min thermal laser acupuncture treatment at acupoint Dubi (ST 35 three times a week for two weeks and twice a week for another four weeks. Outcome assessments were performed immediately after the first treatment, and at weeks 2, 6, and 10. Group A function scores were significantly better than those of Group B at weeks 2 (P=0.049, 6 (P=0.046, and 10 (P=0.042, but no significant differences were found between the two groups in pain and stiffness scores at any time point. No significant adverse effect was observed. The combined 10.6 μm–650 nm laser treatment might be most beneficial to yang deficiency cold coagulation knee OA patients, particularly in improving function.

  3. Lead Screening for HIV-1 Integrase (IN Inhibited by Traditional Chinese Medicine

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    Tzu-Chieh Hung

    2014-01-01

    Full Text Available Human immunodeficiency virus causes the acquired immunodeficiency syndrome (AIDS and becomes a serious world-wide problem because of this disease's rapid propagation and incurability. Integrase strand transfer inhibitors (INSTIs supports HIV have rapid drug resistance for antitreatment. Screening the traditional Chinese medicine (TCM database by simulating molecular docking and molecular dynamics may select molecular compounds to inhibit INSTIs against HIV drug resistance. (S-cathinone and (1S,2S-norpseudoephedrine are selected based on structure and ligand-based drugs are designed and then get higher bioactivity predicted score from SVM than Raltegravir and other TCM compounds. The molecular dynamics are helpful in the analysis and detection of protein-ligand interactions. According to the docking poses, hydrophobic interactions and hydrogen bond variations define the main regions of important amino acids in integrase. In addition to the detection of TCM compound efficacy, we suggest (1S,2S-norpseudoephedrine is better than the others based on the analysis of interaction and the effect on the structural variation.

  4. Serum metabolomics study of Traditional Chinese medicine formula intervention to polycystic ovary syndrome.

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    Lu, Caixia; Zhao, Xinjie; Li, Yan; Li, Yanjie; Yuan, Chengkun; Xu, Fang; Meng, Xiaoyu; Hou, Lihui; Xu, Guowang

    2016-02-20

    Polycystic ovary syndrome (PCOS) is a most common, heterogeneous, complex endocrinopathy disease. Traditional Chinese medicine (TCM) has been used in the treatment of PCOS for many years. However, the mechanism underlying TCM remains obscure and challenging. In this study, 30 PCOS subjects were separated into normoinsulinemic group (NI=13) and hyperinsulinemic group (HI=17), and treated for three menstrual cycles with TCM Formula, Bushen Huatan Formula (BHF). A metabolomics approach based on ultra-high-performance liquid chromatography (UPLC) coupled with linear ion trap Orbi-trap mass spectrometer (LTQ Orbi-trap MS) is used to investigate serum metabolic changes of TCM intervention to PCOS. After BHF intervention for three menstrual cycles, the serum levels of glycerophosphorylethanolamine (GPEA), creatine, creatinine decreased in both NI and HI groups. Furthermore, in NI group, the main manifestation was the changes of phospholipid metabolism. While in HI group, lysine, phenol sulfate, phe-phe etc. decreased, and ornithine, proline, betaine, acetylcholine etc. increased. Combined with clinical biochemical data, BHF was proved effective to PCOS by reducing the inflammatory reaction and oxidative stress. This study also illustrates that the LC-MS based metabolomic approach is a helpful tool to evaluate curative effect and to understand the mechanisms of TCM.

  5. Application of Thermal Science to Tongue Inspection in Traditional Chinese Medicine

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    诸凯; 魏璠; 马一太; 何坚; 张伯礼; 高秀梅; 王怡

    2004-01-01

    The study on Traditional Chinese Medicine (TCM)by the technology and method of thermal science is a new cut-in point in interdisciplinary science, and its purpose is to study the tongue inspection in TCM from the view of the bio-heat transfer theory. In this paper human tongues were studied with the infrared thermal imaging technology. And the characteristic relationship between temperature distribution and age, tongue color as well as infrared thermal tongue image concerning the characteristic of viscera was analyzed by the experimental data,which confirms that the change in temperature distribution in different positions of the tongue is related to the diseases of different internal organs of the body. From a series of invasive experiments in animals, the blood perfusion rate was measured with the equipment of CBI-8000 Doppler Blood Flow Meter and MP-100 Physiologic Research System for the first time and the characteristic relationship curve between the temperature on the surface of the tongue and the blood perfusion rate was obtained. From the experiments the temperature on the surface of the tongue reflects objectively the tongue color which is influenced by the blood perfusion rate. This will help to develop some new cognition in the theory of TCM.

  6. Vascular Contributions to Cognitive Impairment and Treatments with Traditional Chinese Medicine

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    Xinhua Zhou

    2016-01-01

    Full Text Available The prevalence of cognitive impairment and dementia caused by cerebrovascular disease is likely to increase with the global aging population. Vascular contributions to cognitive impairment and dementia (VCID is a wide spectrum term used to include a diverse heterogeneous group of cognitive syndromes with vascular factors regardless of the cause of pathogenesis. VCID ranges from mild cognitive impairment to full-blown dementia with vascular dementia (VaD as the most severe stage. It is further complexed by the coexistence of other forms of dementia such as Alzheimer’s disease (AD. Recent researches in the functions of the neurovascular unit (NVU suggest that dysfunction of the NVU might be the cause of primary vascular events in the brain that leads to further neurodegeneration. In this review, we have briefly summarized various forms of VCID. There is currently no standard therapy for VCID or dementia. Given the fact that Traditional Chinese Medicine (TCM has gained popularity worldwide, we also reviewed recent scientific and clinical findings on various antidementia TCM for the treatment of VCID, including Salvia miltiorrhiza, Huperzia serrata, Ligusticum chuanxiong, Ginkgo biloba, Panax ginseng, and also TCM formula Sailuotong capsule (SLT and Fufangdanshen tablets (FFDS.

  7. Amelioration effects of traditional Chinese medicine on alcohol-induced fatty liver

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    Hyun-Jeong Kwon; Yun-Young Kim; Se-Young Choung

    2005-01-01

    AIM: To examine the effects of traditional Chinese medicine (TCM) on alcohol-induced fatty liver in rats. TCM consists of Astragalus membranaceus, Morus alba, Crataegus pinnatifida,Alisma orientale, Salvia miltiorrhiza, and Pueraria lobata.METHODS: The rats were separated randomly into five groups. One (the CD group) was fed a control diet for 10 wk, another (the ED group) fed an ethanol-containing isocaloric liquid diet for 10 wk, and the last three (the TCM group) were fed an ethanol-containing isocaloric liquid TCM2000, respectively) weekly during the last 4 wk.RESULTS: ED group developed fatty liver according to lipid profile and liver histological findings. Compared with the control group, liver/body weight, serum triglyceride (TG) and total cholesterol (TC), liver TG and TC, serum alanine aminotransferase (ALT) and aspartic aminotransferase (AST) significantly increased in the ED group.Whereas, in the rats administered with TCM, liver/body weight, serum TG and TC, liver TG and TC, serum ALT and AST were significantly decreased, and the degree of hepatic lipid droplets was markedly improved compared with those in the ED group.CONCLUSION: TCM treatment causes significant reduction in alcohol-induced lipid hepatic accumulation,reversing fatty liver and liver damage, and can be usedas a remedy for alcoholic fatty liver.

  8. Traditional Chinese Medicine-Based Network Pharmacology Could Lead to New Multicompound Drug Discovery

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    Jian Li

    2012-01-01

    Full Text Available Current strategies for drug discovery have reached a bottleneck where the paradigm is generally “one gene, one drug, one disease.” However, using holistic and systemic views, network pharmacology may be the next paradigm in drug discovery. Based on network pharmacology, a combinational drug with two or more compounds could offer beneficial synergistic effects for complex diseases. Interestingly, traditional chinese medicine (TCM has been practicing holistic views for over 3,000 years, and its distinguished feature is using herbal formulas to treat diseases based on the unique pattern classification. Though TCM herbal formulas are acknowledged as a great source for drug discovery, no drug discovery strategies compatible with the multidimensional complexities of TCM herbal formulas have been developed. In this paper, we highlighted some novel paradigms in TCM-based network pharmacology and new drug discovery. A multiple compound drug can be discovered by merging herbal formula-based pharmacological networks with TCM pattern-based disease molecular networks. Herbal formulas would be a source for multiple compound drug candidates, and the TCM pattern in the disease would be an indication for a new drug.

  9. BATMAN-TCM: a Bioinformatics Analysis Tool for Molecular mechANism of Traditional Chinese Medicine

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    Liu, Zhongyang; Guo, Feifei; Wang, Yong; Li, Chun; Zhang, Xinlei; Li, Honglei; Diao, Lihong; Gu, Jiangyong; Wang, Wei; Li, Dong; He, Fuchu

    2016-02-01

    Traditional Chinese Medicine (TCM), with a history of thousands of years of clinical practice, is gaining more and more attention and application worldwide. And TCM-based new drug development, especially for the treatment of complex diseases is promising. However, owing to the TCM’s diverse ingredients and their complex interaction with human body, it is still quite difficult to uncover its molecular mechanism, which greatly hinders the TCM modernization and internationalization. Here we developed the first online Bioinformatics Analysis Tool for Molecular mechANism of TCM (BATMAN-TCM). Its main functions include 1) TCM ingredients’ target prediction; 2) functional analyses of targets including biological pathway, Gene Ontology functional term and disease enrichment analyses; 3) the visualization of ingredient-target-pathway/disease association network and KEGG biological pathway with highlighted targets; 4) comparison analysis of multiple TCMs. Finally, we applied BATMAN-TCM to Qishen Yiqi dripping Pill (QSYQ) and combined with subsequent experimental validation to reveal the functions of renin-angiotensin system responsible for QSYQ’s cardioprotective effects for the first time. BATMAN-TCM will contribute to the understanding of the “multi-component, multi-target and multi-pathway” combinational therapeutic mechanism of TCM, and provide valuable clues for subsequent experimental validation, accelerating the elucidation of TCM’s molecular mechanism. BATMAN-TCM is available at http://bionet.ncpsb.org/batman-tcm.

  10. Discovery of novel insomnia leads from screening traditional Chinese medicine database.

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    Chen, Hsin-Yi; Chang, Su-sen; Chan, Yueh-Chiu; Chen, Calvin Yu-Chian

    2014-01-01

    Insomnia is a prominent modern disease that affects an increasing population. Undesirable side effects of commercial drugs highlight the need to develop novel insomnia drugs. Virtual screening of traditional chinese medicine Database@Taiwan (TCM Database@Taiwan) identified 2-O-Caffeoyl tartaric acid (1), 2-O-Feruloyl tartaric acid (2), and Mumefural (3) as potential agonists for both gamma-amino butyric acid (GABA) or benzodiazepine (BZ) binding sites. The TCM candidates exhibited higher affinity than GABA and Zolpidem, a phenomenon that could be attributed to higher quantity of stabilizing H-bonds. Efficacy profiles using support vector machines and pharmacophore contour also suggest drug potential of the TCM candidates. Fragments added to the de novo derivatives 3a, 3b, 3c for GABA binding site, and 1a, 2a, and 3d for BZ binding site contributed to new binding sites and structural stability, further optimizing binding to GABA or BZ binding sites. Increased opening of the ion channel by candidate ligands provide strong support for their potential biological functions. The dual binding properties of the TCM candidates present a unique opportunity to develop twin-targeting drugs with less side effects. Derivative structures can be used as starting points for developing high affinity GABAA receptor agonists with specificity towards GABA binding site and BZ binding site.

  11. Merging traditional Chinese medicine with modern drug discovery technologies to find novel drugs and functional foods.

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    Graziose, Rocky; Lila, Mary Ann; Raskin, Ilya

    2010-03-01

    Traditional Chinese Medicines (TCM) are rapidly gaining attention in the West as sources of new drugs, dietary supplements and functional foods. However, lack of consistent manufacturing practices and quality standards, fear of adulteration, and perceived deficiencies in scientific validation of efficacy and safety impede worldwide acceptance of TCM. In addition, Western pharmaceutical industries and regulatory agencies are partial toward single ingredient drugs based on synthetic molecules, and skeptical of natural product mixtures. This review concentrates on three examples of TCM-derived pharmaceuticals and functional foods that have, despite these usual obstacles, risen to wide acceptance in the West based on their remarkable performance in recent scientific investigations. They are: Sweet wormwood (Artemisia annua), the source of artemisinin, which is the currently preferred single compound anti-malarial drug widely used in combination therapies and recently approved by US FDA; Thunder god vine (Tripterygium wilfordii) which is being developed as a botanical drug for rheumatoid arthritis; and green tea (Camellia sinensis) which is used as a functional beverage and a component of dietary supplements.

  12. Five-year outcomes of western mental health training for Traditional Chinese Medicine practitioners

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    Tai Pong Lam

    2016-10-01

    Full Text Available Abstract Background There are increasing expectations for primary care practitioners to deal with mental health problems. In Hong Kong, 15 % of the general public consult Traditional Chinese Medicine (TCM practitioners regularly for their primary health care needs. This study investigated the 5-year outcomes of a western mental health training course for TCM practitioners in Hong Kong. Method Structured questionnaire surveys were conducted to compare the TCM practitioners’ confidence and engagement in mental health care before and after the Course. The data collected during 2011–2015 were analyzed. Results A total of 151 TCM practitioners returned both pre- and post-Course questionnaires, with a response rate of 95.6 %. After the course, there were significant increases in the proportions of participants being confident of recognizing patients with psychological problems (62.9 % before the course vs 89.4 % after, diagnosing common mental health problems (47.7 % vs 77.5 %, and managing them (31.2 % vs 64.3 %. Overall, 66.9 % of the participants reported some increase in their confidence in recognizing patients with psychological problems, diagnosing or/and managing patients with common mental health problems. Qualitative responses illustrated the major improvements were increased awareness of mental symptoms, better understanding of classification of mental disorders and management approaches. On the other hand, barriers included difficulties in understanding medical terms in English, consultation time constraints, and a lack of formal referral system to psychiatrists. Conclusions The Course has positive impact on TCM practitioners in handling mental health patients. The findings are useful for designing similar trainings on complementary and alternative medicine practitioners in other countries.

  13. Gender differences in traditional Chinese medicine use among adults in Taiwan.

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    Chun-Chuan Shih

    Full Text Available OBJECTIVES: The increasing use of complementary, alternative medicine (CAM and traditional Chinese medicine (TCM has attracted attention. We report on the gender difference in TCM use among the general population in Taiwan in a population-based, cross-sectional study. METHODS: We collected data on socio-demographic factors, lifestyle and health behavior from the 2001 Taiwan National Health Interview Survey. The medical records of interviewees aged 20-69 years were obtained from National Health Insurance claims data with informed consent. The prevalence of TCM use and the average frequency of TCM use were compared between women and men. RESULTS: Among 14,064 eligible participants, the one-year prevalence of TCM use for women and men was 31.8% and 22.4%, respectively. Compared with men, women had a higher average TCM use frequency (1.55 visits vs. 1.04 visits, p<0.001. This significant difference remained evident after excluding gender-specific diseases (1.43 visits vs. 1.03 visits, p<0.001. The average TCM use frequency was significantly higher in women than in men across all age groups. TCM use correlates differed for women and men. Marital status (odds ratio [OR] = 1.55, 95% confidence interval [CI] = 1.30-1.85, family income and unhealthy lifestyle (OR = 1.50, 95% CI = 1.30-1.74 were factors associated with TCM use in men but not in women. CONCLUSIONS: In Taiwan, women used more TCM services than men and the gender differences in the TCM use profile persisted across age groups.

  14. Characteristics of Traditional Chinese Medicine Use in Pediatric Dislocations, Sprains and Strains

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    Chung-Yen Lu

    2017-02-01

    Full Text Available Background and Objectives: Dislocations, sprains and strains are common childhood musculoskeletal injuries, requiring medical attention. We investigated the characteristics associated with using traditional Chinese medicine (TCM for children suffering from these injuries. Methods: From a nationwide representative insurance database of Taiwan, this cross-sectional study identified 50,769 children with dislocations, sprains and strains under 18 years of age, newly diagnosed between 1999 and 2009, without previous TCM experience. Children who initiated treatment with TCM (n = 24,063, 47.4% were defined as TCM users, others were in the non-TCM group. Multivariable logistic regression models estimated odds ratios (ORs of TCM use. Results: Girls and children living in central Taiwan (vs. northern were associated with higher TCM use. The adjusted ORs (95% confidence interval (CI of TCM uses were 1.60 (1.42–1.79 for patients of 3–5 years, 2.20 (1.99–2.42 of 6–12 years and 1.82 (1.64–2.01 of 13–17 years, compared with those of the <2 years group. TCM users were less likely to have outpatient visits for Western medicine care and hospitalizations in the previous year. The TCM group was nearly twice more likely than the non-user group to receive treatments at local clinics (99.1% vs. 53.3%, p < 0.001. Conclusions: This study reveals important demographic and medical factors associated with TCM uses for children with dislocations, sprains and strains. Interestingly, local clinics are the main healthcare facilities providing TCM services. Further studies are needed to evaluate the outcomes of TCM treatment for these musculoskeletal injuries.

  15. Preliminary Study on Traditional Chinese Medicine Pharmacovigilance%中药药物警戒初探

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    梁丽娟; 赵奎君

    2011-01-01

    OBJECTIVE:To discuss the theory of traditional Chinese medicine (TCM) pharmacovigilance preliminarily, and to provide reference for the development of TCM pharmacovigilance. METHODS: By summarizing the origin, definition and development of pharmacovigilance theory and comparing with the theory of traditional pharmacovigilance in China, TCM pharmacovigilance was discussed preliminarily. RESULTS: The carrying out of TCM Pharmacovigilance should supervise the whole process from cultivation, collection, processing to production, post-marketing study to rational clinical usage of TCM, especially the supervision of toxic herbs. CONCLUSION: The constant perfection of TCM pharmacovigilance need to pay attention to the safety problems in the application of TCM.%目的:对中药药物警戒理论进行初步探讨,为中药药物警戒工作的开展提供依据.方法:整理药物警戒理论的起源、定叉和发展,与我国传统药物警戒理论进行对比,并进一步对中药药物警戒工作的主要内容进行探讨.结果:开展药物警戒工作除应对中药的种植、采集、加工炮制乃至生产、上市后进行监管外,还应对合理的临床应用的全过程进行监管,尤其应加强对有毒中药的监控.结论:重视中药使用过程中的安全性问题才能不断地完善中药药物警戒工作.

  16. Network target for screening synergistic drug combinations with application to traditional Chinese medicine

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    Zhang Ningbo

    2011-06-01

    Full Text Available Abstract Background Multicomponent therapeutics offer bright prospects for the control of complex diseases in a synergistic manner. However, finding ways to screen the synergistic combinations from numerous pharmacological agents is still an ongoing challenge. Results In this work, we proposed for the first time a “network target”-based paradigm instead of the traditional "single target"-based paradigm for virtual screening and established an algorithm termed NIMS (Network target-based Identification of Multicomponent Synergy to prioritize synergistic agent combinations in a high throughput way. NIMS treats a disease-specific biological network as a therapeutic target and assumes that the relationship among agents can be transferred to network interactions among the molecular level entities (targets or responsive gene products of agents. Then, two parameters in NIMS, Topology Score and Agent Score, are created to evaluate the synergistic relationship between each given agent combinations. Taking the empirical multicomponent system traditional Chinese medicine (TCM as an illustrative case, we applied NIMS to prioritize synergistic agent pairs from 63 agents on a pathological process instanced by angiogenesis. The NIMS outputs can not only recover five known synergistic agent pairs, but also obtain experimental verification for synergistic candidates combined with, for example, a herbal ingredient Sinomenine, which outperforms the meet/min method. The robustness of NIMS was also showed regarding the background networks, agent genes and topological parameters, respectively. Finally, we characterized the potential mechanisms of multicomponent synergy from a network target perspective. Conclusions NIMS is a first-step computational approach towards identification of synergistic drug combinations at the molecular level. The network target-based approaches may adjust current virtual screen mode and provide a systematic paradigm for facilitating the

  17. Treatment of abdominal compartment syndrome in severe acute pancreatitis patients with traditional Chinese medicine

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    Min-Jie Zhang; Guo-Lei Zhang; Wen-Bin Yuan; Jun Ni; Li-Feng Huang

    2008-01-01

    AIM: To investigate the therapeutic effect of traditional Chinese traditional medicines Da Cheng Qi Decoction (Timely-Purging and Yin-Preserving Decoction) and Glauber's salt combined with conservative measures on abdominal compartment syndrome (ACS) in severe acute pancreatitis (SAP) patients.METHODS: Eighty consecutive SAP patients, admitted for routine non-operative conservative treatment, were randomly divided into study group and control group (40 patients in each group). Patients in the study group received Da Cheng Qi Decoction enema for 2h and external use of Glauber's salt, once a day for 7d. Patients in the control group received normal saline (NS) enema. Routine non-operative conservative treatments included non-per os nutrition (NPON), gastrointestinal decompression, life support, total parenteral nutrition (TPN), continuous peripancreatic vascular pharmaceutical infusion and drug therapy. Intra-cystic pressure (ICP) of the two groups was measured during treatment. The effectiveness and outcomes of treatment were observed and APACHE Ⅱ scores were applied in analysis.RESULTS: On days 4 and 5 of treatment, the ICP was lower in the study group than in the control group (P<0.05). On days 3-5 of treatment, acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ) scores for the study and control groups were significantly different (P<0.05). Both the effectiveness and outcome of the treatment with Da Cheng Qi Decoction on abdominalgia, burbulence relief time, ascites quantity, cyst formation rate and hospitalization time were quite different between the two groups (P<0.05). The mortality rate for the two groups had no significant difference.CONCLUSION: Da Cheng Qi Decoction enema and external use of Glauber's salt combined with routine non-operative conservative treatment can decrease the intra-abdominal pressure (IAP) of SAP patients and have preventive and therapeutic effects on abdominal compartment syndrome of SAR.

  18. [Systems biology is a bridge of integrated traditional Chinese and Western medicine].

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    Chen, Hai-Bin; Cheng, Hai-Bo; Lu, Wei; Zhou, Hong-Guang; Wu, Mian-Hua

    2013-01-01

    The integration of Chinese medicine (CM) and Western medicine (WM) is the only way for the development of medicine, and it is the best form for unifying systems theory and reductionism. In this paper, systems biology and its application in medical research were discussed. The authors put forward that systems biology may possibly interpret the scientific connotation of the complex theoretic systems of CM, which will make WM to well know the human body and disease. We hold that systems biology is a bridge of integrated CM and WM.

  19. 中医养生学与现代康复%Therapy of health preserving of traditional Chinese medicine and modern rehabilitation

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    汤凤珍

    2003-01-01

    @@ INTRODUCTION Traditional medicine and modem medicine are considered as twomain medic al systems and exist cooperately in our countrylong-term. The formation of traditional nedicine goes back to ancienttimes. The author thinks that extent the principle and method ofmodem rehabilitation are similar on some extent with therapy ofhealth preserving of traditional Chinese medicine. The later mainlystudy the contents of building body and preventing disease in order toprolong the time of life. It is essential of bringing into play thetherapy of health preserving of traditional Chinese medicine forbuilding the system of modem rehalbilitation having Chinese charac-teristics. Through developing and popularizing the therapy of healthpreserving of traditional Chinese medicine, the development of mod-ern rehabilitation can be accelerated.

  20. Effects of traditional Chinese patent medicine on essential hypertension: a systematic review.

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    Xiong, Xingjiang; Wang, Pengqian; Zhang, Yuqing; Li, Xiaoke

    2015-02-01

    Traditional Chinese patent medicine (TCPM) is widely used for essential hypertension (EH) in China. However, there is no critically appraised evidence, such as systematic reviews or meta-analyses, regarding the potential benefits and disadvantages of TCPM to justify their clinical use and recommendation. The aim of this review was to systematically evaluate and meta-analyze the effects of TCPM for EH. Seven databases, the Cochrane Library, PubMed, EMBASE, the China National Knowledge Infrastructure, the Chinese Scientific Journal Database, the Chinese Biomedical Literature Database, and the Wanfang Database, were searched from their inception to August 2014 for relevant studies that compared one TCPM plus antihypertensive drugs versus antihypertensive drugs alone. The methodological quality of the included trials was assessed using the Cochrane risk-of-bias tool. The primary outcome measures were mortality or progression to severe complications and adverse events. The secondary outcome measures were blood pressure (BP) and quality of life (QOL). Seventy-three trials, which included 8138 patients, on 17 TCPMs were included. In general, the methodological quality was low. Two trials evaluated the effects of TCPMs on mortality and the progression to severe complications after treatment, and no significant difference was identified compared with antihypertensive drugs alone. No severe adverse events were reported. Thirteen TCPMs used in complementary therapy significantly decreased systolic BP by 3.94 to 13.50 mmHg and diastolic BP by 2.28 to 11.25 mmHg. QOL was significantly improved by TCPM plus antihypertensive drugs compared with antihypertensive drugs alone. This systematic review provided the first classification of clinical evidence for the effectiveness of TCPM for EH. The usage of TCPMs for EH was supported by evidence of class level III. As a result of the methodological drawbacks of the included studies, more rigorously designed randomized controlled trials

  1. A web-based knowledge management system integrating Western and Traditional Chinese Medicine for relational medical diagnosis.

    Science.gov (United States)

    Herrera-Hernandez, Maria C; Lai-Yuen, Susana K; Piegl, Les A; Zhang, Xiao

    2016-10-26

    This article presents the design of a web-based knowledge management system as a training and research tool for the exploration of key relationships between Western and Traditional Chinese Medicine, in order to facilitate relational medical diagnosis integrating these mainstream healing modalities. The main goal of this system is to facilitate decision-making processes, while developing skills and creating new medical knowledge. Traditional Chinese Medicine can be considered as an ancient relational knowledge-based approach, focusing on balancing interrelated human functions to reach a healthy state. Western Medicine focuses on specialties and body systems and has achieved advanced methods to evaluate the impact of a health disorder on the body functions. Identifying key relationships between Traditional Chinese and Western Medicine opens new approaches for health care practices and can increase the understanding of human medical conditions. Our knowledge management system was designed from initial datasets of symptoms, known diagnosis and treatments, collected from both medicines. The datasets were subjected to process-oriented analysis, hierarchical knowledge representation and relational database interconnection. Web technology was implemented to develop a user-friendly interface, for easy navigation, training and research. Our system was prototyped with a case study on chronic prostatitis. This trial presented the system's capability for users to learn the correlation approach, connecting knowledge in Western and Traditional Chinese Medicine by querying the database, mapping validated medical information, accessing complementary information from official sites, and creating new knowledge as part of the learning process. By addressing the challenging tasks of data acquisition and modeling, organization, storage and transfer, the proposed web-based knowledge management system is presented as a tool for users in medical training and research to explore, learn and

  2. Daucosterol derived from Cordyceps (a Traditional Chinese Medicine as a possible lead compound for allergic transfusion reactions

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    Jian Yang

    2015-03-01

    Full Text Available Allergic transfusion reaction is an anomaly that develops within several hours of transfusion which is usually treated by antihistamine. In the present study, we are looking into daucosterol, an extract of Traditional Chinese Medicine (TCM Cordyceps, as a potential inhibitor of histidine decarboxylase. The approach of molecular docking and Molecular Dynamics Simulation (MDS on a traditional anti-inflammatory Chinese medicine gave an atomic insight of the inhibition. The daucosterol was binding with a ΔG of -3.17 Kcal/mol, to inhibit histamine synthesis by binding to histidine decarboxylase, possibly via the flexible catalytic loop. Such inhibitors that were designed to block the flexibility of the catalytic loop are potential candidates for further drug development program.

  3. Solid-phase extraction of esculetin from the ash bark of Chinese traditional medicine by using molecularly imprinted polymers.

    Science.gov (United States)

    Hu, Shu-Guo; Li, Li; He, Xi-Wen

    2005-01-07

    A molecularly imprinted polymer solid-phase extraction method is used to extract esculetin from the ash bark of Chinese traditional medicine. Ratio of ethanol and water as washing solution were investigated. Data of accumulative adsorption on molecularly imprinted polymers from the continuous loading experiment suggests that there are two different kinds of recognition sites in molecularly imprinted polymers. By selecting the washing and eluting solution a scheme was designed to separate esculetin and its analogues including esculin, coumarin, 7-methoxylcoumarin and daphnetin. Finally, by applying the revised scheme esculetin was extracted from the ash bark of Chinese traditional medicine that was purchased from two big drugstores, respectively, with both molecularly imprinted polymers and non-molecularly imprinted polymers.

  4. Research Overview on Traditional Chinese Medicine Processed With Vinegar%中药醋制研究概况

    Institute of Scientific and Technical Information of China (English)

    陈新梅; 徐溢明

    2016-01-01

    本文对中药醋制的研究新进展进行综述。对中药醋制的历史、分类、方法、醋制前后化学成分的变化、药理变化等方面进行介绍。中药醋制对于中药的临床应用具有极其重要的意义。%The latest progress on traditional Chinese medicine processed with vinegar was reviewed .History, classification , technology , chemical constituents changes before and after processed with vinegar were introduced .The process with vinegar was of vital importance for clinical application of traditional Chinese medicine .

  5. [Application of nested case-control study on safe evaluation of post-marketing traditional Chinese medicine injection].

    Science.gov (United States)

    Xiao, Ying; Zhao, Yubin; Xie, Yanming

    2011-10-01

    The nested case-control study design (or the case-control in a cohort study) is described here as a new study design used in safe evaluation of post-marketing traditional Chinese medicine injection. In the nested case-control study, cases of a disease that occur in a defined cohort are identified and, for each, a specified number of matched controls is selected from among those in the cohort who have not developed the disease by the time of disease occurrence in the case. For many research questions, the nested case-control design potentially offers impressive reductions in costs and efforts of data collection and analysis compared with the full cohort approach, with relatively minor loss in statistical efficiency. The nested case-control design is particularly advantageous for studies in safe evaluation of post-marketing traditional Chinese medicine injection. Some examples of the application of nested case-control study were given.

  6. Summary of traditional Chinese medicine in the treatment of alopecia areata%斑秃中医治法概要

    Institute of Scientific and Technical Information of China (English)

    陆熙铭; 陆文生

    2016-01-01

    This paper summarizes the clinical of traditional Chinese medicine for the treatment of alopecia areata, so as to provide reference for clinical treatment of alopecia areata.%本研究具体综述了中医药临床对于斑秃的治疗方法,以期为斑秃的临床治疗提供参考。

  7. A Survey of Researches on Synergy and Toxicity Abatement of Traditional Chinese Medicine in Radiotherapy of Nasopharyngeal Carcinoma

    Institute of Scientific and Technical Information of China (English)

    刘城林; 刘丽萍; 李佩文

    2001-01-01

    @@ Even though radiotherapy is a therapy of first choice in the treatment of nasopharyngeal carcinoma, its radiotoxicity is often difficult to bear for patients in addition to the unsatisfactory effect in some patients. Therefore, an important problem in the treatment of nasopharyngeal carcinoma is to abate radiotherapeutic toxicity and improve its effect. Some progresses in promoting the effect of radiotherapy and abating its toxicity have been made through application of traditional Chinese medicine (TCM) which is briefly reviewed as follows.

  8. Assessment and Explorations on the Mechanism of Neuroprotection of Patients in Ischemic Stroke by Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Ischemic stroke is a common clinical emergency, with thrombolysis and neuroprotection as its cardinal treatment, and nowadays the latter is more and more stressed by stroke researchers. On the basis of pathophysiology and ischemic cascade of ischemic stroke, we now try to analyze the conceivable mechanism of intervention by tradition Chinese medicine (TCM) and hopefully provide experience for experimental and clinical research in the future.

  9. Understanding molecular mechanisms of traditional Chinese medicine for the treatment of influenza viruses infection by computational approaches.

    Science.gov (United States)

    Gu, Shuo; Yin, Ning; Pei, Jianfeng; Lai, Luhua

    2013-11-01

    The battle against influenza is an enduring one. For hundreds of years, people have fought such small viruses with practices such as traditional Chinese medicine (TCM), however only recently has it been possible to use cutting-edge technology to investigate their mechanisms. Here, we re-created this ancient Chinese knowledge to explore the chemistry of herbs and elucidate their mechanism of action using molecular computational methods. Our results show that TCM compounds can inhibit influenza viral proteins in a multi-target/multi-component manner, revealing the versatility of TCM for treating different influenza virus subtypes, including the recently emerged H7N9.

  10. Traditional Chinese medicine therapy decreases the pneumonia risk in patients with dementia.

    Science.gov (United States)

    Lin, Shun-Ku; Tsai, Yueh-Ting; Lo, Pei-Chia; Lai, Jung-Nien

    2016-09-01

    Pneumonia is a frequent complication in dementia patients and is associated with high mortality rates. The aim of this retrospective cohort study was to determine whether traditional Chinese medicine (TCM) therapy can decrease pneumonia risk in dementia patients. The cohort dataset was obtained from the Longitudinal Health Insurance Database 2005, a sublibrary of the National Health Insurance Research Database, containing all medical data of 1 million beneficiaries, randomly selected from the all Insurers in year 2005.Newly diagnosed dementia patients (n = 9712) without pneumonia were analyzed from January 1997 to December 2003. After matching by sex, age, urban level, Charlson comorbidity index, insured amount, and comorbidities, 1376 pairs (1:1) of TCM and non-TCM users were acquired. Every dementia patient was individually recorded from 1997 to 2012 to identify pneumonia incidence (onset after 3 months of dementia diagnosis).Demographic characteristics, Charlson comorbidity index, comorbidities, behavioral and psychological symptoms of dementia, and psychotropic drugs were also investigated. Cox proportional regression was used to compute hazard ratios and 95% confidence intervals (CIs) after adjustment for the above-mentioned variables.There were 419 (30.5%) and 762 (55.4%) pneumonia cases in the TCM and non-TCM cohorts during a mean follow-up period of 7.6 years. The adjusted hazard ratios (95% CI) for pneumonia admission was 0.62 (0.55-0.70) for the TCM group.Patients who received TCM therapy at higher cumulative doses or for longer periods experienced increased protection from pneumonia admission. Ma-Xing-Gan-Shi-Tang, Yin-Qiao-San, and Xiao-Qing-Long-Tang might represent possible formulae reducing the incidence of pneumonia. TCM might be associated with a lower risk of pneumonia in dementia patients.

  11. Evaluation of Women with Myofascial Abdominal Syndrome Based on Traditional Chinese Medicine

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    Andréia Mitidieri

    2015-12-01

    Full Text Available Objectives: This study used semiology based on traditional Chinese medicine (TCM to investigate vital energy (Qi behavior in women with abdominal myofascial pain syndrome (AMPS. Methods: Fifty women diagnosed with chronic pelvic pain (CPP secondary to AMPS were evaluated by using a questionnaire based on the theories of “yin-yang,” “zang-fu”, and “five elements”. We assessed the following aspects of the illness: symptomatology; specific location of myofascial trigger points (MTrPs; onset, cause, duration and frequency of symptoms; and patient and family history. The patients tongues, lips, skin colors, and tones of speech were examined. Patients were questioned on various aspects related to breathing, sweating, sleep quality, emotions, and preferences related to color, food, flavors, and weather or seasons. Thirst, gastrointestinal dysfunction, excreta (feces and urine, menstrual cycle, the five senses, and characteristic pain symptoms related to headache, musculoskeletal pain, abdomen, and chest were also investigated. Results: Patients were between 22 and 56 years old, and most were married (78%, possessed a elementary school (66%, and had one or two children (76%. The mean body mass index and body fat were 26.86 kg/ cm2 (range: 17.7 — 39.0 and 32.4% (range: 10.7 — 45.7, respectively. A large majority of women (96% exhibited alterations in the kidney meridian, and 98% had an altered gallbladder meridian. We observed major changes in the kidney and the gallbladder Qi meridians in 76% and 62% of patients, respectively. Five of the twelve meridians analyzed exhibited Qi patterns similar to pelvic innervation Qi and meridians, indicating that the paths of some of these meridians were directly related to innervation of the pelvic floor and abdominal region. Conclusion: The women in this study showed changes in the behavior of the energy meridians, and the paths of some of the meridians were directly related to innervation of the

  12. Enhanced stability and antibacterial efficacy of a traditional Chinese medicine-mediated silver nanoparticle delivery system.

    Science.gov (United States)

    Sun, Wenjie; Qu, Ding; Ma, Yihua; Chen, Yan; Liu, Congyan; Zhou, Jing

    2014-01-01

    Silver nanoparticles (AgNPs) are widely used as antibacterial products in various fields. Recent studies have suggested that AgNPs need an appropriate stabilizer to improve their stability. Some antibacterial traditional Chinese medicines (TCMs) contain various reductive components, which can not only stabilize AgNPs but also enhance their antimicrobial activity. In this study, we developed a series of novel AgNPs using a TCM extract as a stabilizer, reducing agent, and antimicrobial agent (TCM-AgNPs). A storage stability investigation of the TCM-AgNPs suggested a significant improvement when compared with bare AgNPs. Further, conjugation of TCMs onto the AgNP surface resulted in stronger antimicrobial potency on antibacterial evaluation using Pseudomonas aeruginosa, Staphylococcus epidermidis, and Staphylococcus aureus with minimum inhibitory concentration 50% (MIC50) ratios (and minimum bactericidal concentration 90% [MBC90] ratios) of AgNPs to respective TCM-AgNPs as assessment indices. Among these, P. cuspidatum Sieb. et-conjugated AgNPs (P.C.-AgNPs) had the advantage of a combination of TCMs and AgNPs and was studied in detail with regard to its synthesis and characterization. The extraction time, reaction temperature, and concentrations of AgNO3 and Polygonum cuspidatum Sieb. et extract were critical factors in the preparation of P.C.-AgNPs. Further, the results of X-ray diffraction and Fourier transform infrared spectroscopy indicated successful preparation of P.C.-AgNPs. In representative studies, P.C.-AgNPs showed a well-defined spherical shape, a homogeneous small particle size (36.78 nm), a narrow polydispersity index (0.105), and a highly negative zeta potential (-23.6 mV) on transmission electron microscopy and dynamic light scattering. These results indicate that TCM-AgNPs have a potential role as antibacterial agents in the clinic setting.

  13. Virtual Screening for Potential Allosteric Inhibitors of Cyclin-Dependent Kinase 2 from Traditional Chinese Medicine

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    Fang Lu

    2016-09-01

    Full Text Available Cyclin-dependent kinase 2 (CDK2, a member of Cyclin-dependent kinases (CDKs, plays an important role in cell division and DNA replication. It is regarded as a desired target to treat cancer and tumor by interrupting aberrant cell proliferation. Compared to lower subtype selectivity of CDK2 ATP-competitive inhibitors, CDK2 allosteric inhibitor with higher subtype selectivity has been used to treat CDK2-related diseases. Recently, the first crystal structure of CDK2 with allosteric inhibitor has been reported, which provides new opportunities to design pure allosteric inhibitors of CDK2. The binding site of the ATP-competition inhibitors and the allosteric inhibitors are partially overlapped in space position, so the same compound might interact with the two binding sites. Thus a novel screening strategy was essential for the discovery of pure CDK2 allosteric inhibitors. In this study, pharmacophore and molecular docking were used to screen potential CDK2 allosteric inhibitors and ATP-competition inhibitors from Traditional Chinese Medicine (TCM. In the docking result of the allosteric site, the compounds which can act with the CDK2 ATP site were discarded, and the remaining compounds were regarded as the potential pure allosteric inhibitors. Among the results, prostaglandin E1 and nordihydroguaiaretic acid (NDGA were available and their growth inhibitory effect on human HepG2 cell lines was determined by MTT assay. The two compounds could substantially inhibit the growth of HepG2 cell lines with an estimated IC50 of 41.223 μmol/L and 45.646 μmol/L. This study provides virtual screening strategy of allosteric compounds and a reliable method to discover potential pure CDK2 allosteric inhibitors from TCM. Prostaglandin E1 and NDGA could be regarded as promising candidates for CDK2 allosteric inhibitors.

  14. External Application of Traditional Chinese Medicine for Venous Ulcers: A Systematic Review and Meta-Analysis

    Directory of Open Access Journals (Sweden)

    Xin Li

    2015-01-01

    Full Text Available Objective. To evaluate the effectiveness of external application of traditional Chinese medicine (EA-TCM on venous ulcers. Methods. Seven databases were searched until April 2015 for randomized controlled trials (RCTs of EA-TCM for venous ulcers. Risk of bias was assessed using Cochrane Handbook guidelines. Study outcomes were presented as risk ratios (RRs for dichotomous data or mean differences (MDs for continuous data. Results. Sixteen of 193 potentially relevant trials met the inclusion criteria; however, their methodological qualities were low. Comparison of the same intervention strategies revealed significant differences in total effectiveness rates between EA-TCM and conventional therapy groups (RR = 1.22, 95% confidence interval [CI] = 1.16–1.29, and P<0.00001. Compared to conventional therapy, EA-TCM combined with conventional therapy had a superior total effectiveness rate (RR = 1.11, 95% CI = 1.04–1.19, and P=0.003. There were no significant differences in recurrence rates during followup and final pain measurements between the experimental and those in the control groups (RR = 0.86, 95% CI = 0.31–2.39, and P=0.85; MD −0.75, 95% CI = −2.15–0.65, and P=0.29. Conclusion. The evidence that EA-TCM is an effective treatment for venous ulcers is encouraging, but not conclusive due to the low methodological quality of the RCTs. Therefore, more high-quality RCTs with larger sample sizes are required.

  15. Relationship between Traditional Chinese Medicine Syndrome Type and Coronary Arteriography of Acute Coronary Syndrome

    Institute of Scientific and Technical Information of China (English)

    WANG Xian(王显); LIN Zhong-xiang(林钟香); GE Jun-bo(葛均波); ZHANG Zhen-xian(张振贤); SHEN Lin(沈琳)

    2003-01-01

    Objective: To explore the relationship of Traditional Chinese Medicine (TCM) Syndrome type and coronary arteriography (CAG) with respect to the number and degree of stenosed branches of coronary artery (CA) and ACC/AHA stage of acute coronary syndrome (ACS), to provide an objective evidence for TCM Syndrome typing on ACS.Methods: Ninety patients of ACS with their TCM Syndrome typing and CAG successfully conducted were enrolled in this study. They were classified into 3 Syndrome types, the blood stasis type (typeⅠ), the phlegm stagnant with blood stasis type (typeⅡ), and the endogenous collateral Wind type (typeⅢ). The scores of the number and severity of the stenosis branch of CA and ACC/AHA lesion stage in different Syndrome types were calculated respectively and analysed statistically by Ridit analysis.Results: The number of stenosed branches increased gradually with the Syndrome type changing from Ⅰ→Ⅱ→Ⅲ, compared the type Ⅲ with the other two types(P<0.01). The severity of stenosis in typeⅠ and Ⅱ were similar, but that of Type Ⅲ, much aggravated was significantly different from that in the former two (P<0.01). The ACC/AHA stage of coronary lesion tended to be more complex as the Syndrome type changed, patients of TCM typeⅠ and Ⅱ had mostly lesion of stage A or B1 , while lesion in majority of patients of type Ⅲ belonged to stage B2 or C, comparison between the three types showed significant difference (P<0.01). Conclusion: Most ACS patients of TCM Syndrome type Ⅲ with tri-branch, severe stenosed coronary arteries, belong to the complex ACC/AHA stage of B2 and C.

  16. Thirty-five Infantile Purpura Nephritis Patients Treated with Integrated Traditional Chinese and Western Medicine

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@  Thirty-five patients of infantile purpura nephritis (IPN) were treated with integrated traditional Chinese and western medicine (TCM-WM) from January 1994 to December 1998, with good efficacy obtained, and following is the report. METHODS Clinical Data   All the 65 cases were inpatients, and conformed to the “Standards of the Diagnosis and Therapeutical Effect of Hematological Diseases” (edited by ZHANG Zhi-nan. Tianjin: Tianjin Science and Technology Press, 1999∶235-239). They were randomly divided into two groups: Treated group: 35 cases, 23 males, 12 females; aged 4-13 years, 7 years on average; disease course 4-18 days, the mean 10 days; mild type 19 cases (asymptomatic hematuria, proteinuria), nephritis syndrome type 13 cases (hematuria, proteinuria, edema, hypertension), and nephrotic syndrome type 3 cases (typical manifestation of nephrosis complicated with renal insufficiency). Control group: 30 cases, 20 males, 10 females; aged 3-14 years, 6 years on average; disease course 3-16 days, the mean 9 days; mild type 16 cases, nephritis syndrome type 10 cases, nephrotic syndrome type 4 cases. The clinical manifestation, sex, age, hospitalisation time of these 2 groups showed insignificant difference. Method of Treatment   The control group: Adopting intravenous dripping of dexamethasone 0.3-0.5 mg*kg-1*d-1, consecutively for 5-7 days, which was then shifted to prednisone 1-1.5 mg*kg-1*d-1, altogether 2-3 weeks, with Vit C, persantin, chlorphenamine, calcium, etc., orally taken.   The treated (TCM-WM) group, on the basis of the above-mentioned WM treatment, had also TCM syndrome differentiation performed, and were classified into 3 types:

  17. Application of metabonomic analytical techniques in the modernization and toxicology research of traditional Chinese medicine.

    Science.gov (United States)

    Lao, Yong-Min; Jiang, Jian-Guo; Yan, Lu

    2009-08-01

    In the recent years, a wide range of metabonomic analytical techniques are widely used in the modern research of traditional Chinese medicine (TCM). At the same time, the international community has attached increasing importance to TCM toxicity problems. Thus, many studies have been implemented to investigate the toxicity mechanisms of TCM. Among these studies, many metabonomic-based methods have been implemented to facilitate TCM toxicity investigation. At present, the most prevailing methods for TCM toxicity research are mainly single analysis techniques using only one analytical means. These techniques include nuclear magnetic resonance (NMR), gas chromatography-mass spectrometry (GC-MS), and liquid chromatography-mass spectrometry (LC-MS), etc.; with these techniques, some favourable outcomes have been gained in the toxic reaction studies of TCM, such as the action target organs assay, the establishment of action pattern, the elucidation of action mechanism and the exploration of action material foundation. However, every analytical technique has its advantages and drawbacks, no existing analytical technique can be versatile. Multi-analysed techniques can partially overcome the shortcomings of single-analysed techniques. Combination of GC-MS and LC-MS metabolic profiling approaches has unravelled the pathological outcomes of aristolochic acid-induced nephrotoxicity, which can not be achieved by single-analysed techniques. It is believed that with the further development of metabonomic analytical techniques, especially multi-analysed techniques, metabonomics will greatly promote TCM toxicity research and be beneficial to the modernization of TCM in terms of extending the application of modern means in the TCM safety assessment, assisting the formulation of TCM safety norms and establishing the international standards indicators.

  18. Traditional Chinese Medicine Bionic Tiger Bone Powder for the Treatment of AI-Associated Musculoskeletal Symptoms

    Science.gov (United States)

    Li, Yifan; Zhang, Zhenhua; Cui, Feifei; Liu, Jialing; Wang, Yitong; Jiang, Juling; Ma, Wenxin

    2017-01-01

    Background. Aromatase inhibitors (AIs) are used for adjuvant therapy of breast cancer; however AIMSS (AI-Associated Musculoskeletal Symptoms) can negatively affect quality of life and compliance. Most patients in China moved to TCM (traditional Chinese medicine) for help. TB (tiger bone) is used to treat bone disease, whose main ingredients are calcium and collagen. The objective of this study was to evaluate whether the TB prevented AIMSS in postmenopausal women with ER/PR+ breast cancer. Methods. We conducted a randomized, blind, controlled study of comparing TB versus placebo for 12 weeks in postmenopausal women with breast cancer who have taken AI for less than a month. Patients completed the M-BPI, VAS, and FACT-B at baseline, 6 weeks, and 12 weeks. M-BPI and VAS were used as the primary outcomes. FACT-B was used as the secondary outcome. Serum E2 and FSH were tested every 6 weeks. Results. Of 70 evaluable cases, 8 of 35 patients (22.9%) developed new or worsening point symptoms in TB group, compared to 21 of 35 (60%) in placebo group (P < 0.001). We also found differences between 2 groups in average pain (2 to 5.6), worst pain (3.9 to 8), pain interference severity (1.9 to 5.3), stiffness (2.4 to 6.9), and joint symptom interference (1.8 to 5.7), all P < 0.001; similar findings were seen in VAS value (3 to 6.6) at the end of intervention. HRQoL measured by FACT-B (P < 0.05) was improved. No change of serum estradiol and FSH between two groups. Conclusions. TB appeared to be effective and safe in the prevention of AIMSS. This trial is registered with ChiCTR-IPR-15007081. PMID:28250792

  19. Traditional Chinese Medicine Bionic Tiger Bone Powder for the Treatment of AI-Associated Musculoskeletal Symptoms

    Directory of Open Access Journals (Sweden)

    Yifan Li

    2017-01-01

    Full Text Available Background. Aromatase inhibitors (AIs are used for adjuvant therapy of breast cancer; however AIMSS (AI-Associated Musculoskeletal Symptoms can negatively affect quality of life and compliance. Most patients in China moved to TCM (traditional Chinese medicine for help. TB (tiger bone is used to treat bone disease, whose main ingredients are calcium and collagen. The objective of this study was to evaluate whether the TB prevented AIMSS in postmenopausal women with ER/PR+ breast cancer. Methods. We conducted a randomized, blind, controlled study of comparing TB versus placebo for 12 weeks in postmenopausal women with breast cancer who have taken AI for less than a month. Patients completed the M-BPI, VAS, and FACT-B at baseline, 6 weeks, and 12 weeks. M-BPI and VAS were used as the primary outcomes. FACT-B was used as the secondary outcome. Serum E2 and FSH were tested every 6 weeks. Results. Of 70 evaluable cases, 8 of 35 patients (22.9% developed new or worsening point symptoms in TB group, compared to 21 of 35 (60% in placebo group (P<0.001. We also found differences between 2 groups in average pain (2 to 5.6, worst pain (3.9 to 8, pain interference severity (1.9 to 5.3, stiffness (2.4 to 6.9, and joint symptom interference (1.8 to 5.7, all P<0.001; similar findings were seen in VAS value (3 to 6.6 at the end of intervention. HRQoL measured by FACT-B (P<0.05 was improved. No change of serum estradiol and FSH between two groups. Conclusions. TB appeared to be effective and safe in the prevention of AIMSS. This trial is registered with ChiCTR-IPR-15007081.

  20. [Analysis on influential factors in China's exports of primary and semi-finished products of traditional Chinese medicine to ASEAN].

    Science.gov (United States)

    Qian, Yun-Xu; Yang, Yue; Zhao, Wei; Bi, Kai-Shun

    2014-04-01

    Two regression models, based on panel data over the period of 2000-2011, are built and used to analyze what factors determine China's exports of primary and semi-finished products of traditional Chinese medicine to ASEAN. The results indicate that, China GDP, the ratio of ASEAN to China GDP per capita, average export price, the ratio of state-owned assets to total assets, have a significant positive influence on the export volumes of primary products of Chinese medicine. At the same time, RMB appreciation, the ratio of three kinds of foreign-invested assets to total assets, China-ASEAN Early Harvest Program, ASEAN-China Free Trade Area have a significant negative influence. In respect of the export volumes of semi-finished products of Chinese medicine, the significant influential factors are ASEAN GDP and the ratio of ASEAN to China GDP per capita. The former is positive and the latter is negative. In order to optimize the commodity composition of experts, it is needed to increase export volumes of both primary and semi-finished products of Chinese medicine. According to the analysis above, some proposals are put forward, such as, improving the performance of foreign capital, playing an exemplary and leading role in technological innovation by state-owned enterprises, taking advantage of bargaining power of suppliers, increasing outward foreign direct investment.

  1. Effect of Traditional Chinese Medicine on Survival and Quality of Life in Patients with Esophageal Carcinoma after Esophagectomy

    Institute of Scientific and Technical Information of China (English)

    LU Ping; LIANG Qiu-dong; LI Rong; NIU Hong-rui; KOU Xiao-ge; XI Hong-jun

    2006-01-01

    Objective: To explore the effect and possible mechanism of traditional Chinese medicine (TCM) on survival and quality of life (QOL) in patients with esophageal carcinoma after esophagectomy.Methods: Adopting prospective controlled method of study, the authors had 128 post-esophagectomy patients, hospitalized from February 2001 to February 2002, randomly divided into 3 groups: the TCM group,treated with TCM drugs alone; the chemotherapy group, with chemotherapy alone applied; and the synthetic group, treated with chemotherapy combined with Chinese medicine. Their survival rate and QOL were compared. Results: In the TCM group, the chemotherapy group and the synthetic group, the respective 3-year relapse and remote metastasis rate were 71.4 %, 76.7 %, 53.4 %, respectively (χ2 = 6.53, P<0.05); the 1-year survival rate 42.9%, 46.5%, 72.1%; 2-year survival rate 28.6%, 27.9%, 55.8%, and 3-year survival rate 26. 2%, 23. 1%, 37. 2%, respectively. And the QOL improving rate was 69.0%, 37.2%,58.1%, respectively, all showing significant difference among them (χ2 = 6. 10, all P<0.05). Moreover,immune function was increased in the TCM and the synthetic groups. Conclusion: Integrative Chinese and Western medicinal treatment was the beneficial choice for post-operational patients with esophageal carcinoma. However, long time use of simple Chinese medicine was also advisable, especially for those in poverty.

  2. Traditional Chinese medicine in patients with osteoarthritis of the knee.

    Science.gov (United States)

    Hou, Pu-Wei; Fu, Pin-Kuei; Hsu, Hsin-Cheng; Hsieh, Ching-Liang

    2015-10-01

    To evaluate whether the use of traditional Chinese medicine (TCM; zhōng yī) influences symptoms or functional outcomes in patients with osteoarthritis (OA) of the knee ( xī guān jié yán). A systematic review of randomized control trials was conducted. Searches for studies in PubMed that were performed between 1965 and August 2013, and retrieved studies were subjected to reference screening. The types of studies included in our review were 1) placebo-based or comparative studies; 2) open label, single-blinded or double-blinded studies; 3) studies evaluating the efficacy of TCM for treating OA of the knee; and 4) studies evaluating only TCM or combination preparations. Trials were conducted with participants over 18 years of age with knee pain and at least three of the following characteristics: 1) an age greater than 50 years; 2) morning stiffness lasting for fewer than 30 min; 3) a crackling or grating sensation; 4) bony tenderness of the knee; 5) bony enlargement of the knee; or 6) no detectable warmth of the joint to the touch. Studies were rated for risk of bias and graded for quality. After screening, 104 studies that satisfied the eligibility requirements were identified, and only 18 randomized control trials were included in the quantitative and qualitative synthesis. Upon review, we found "moderate-quality" evidence of effects from acupuncture ( zhēn jiǔ) on pain, which was measured using a visual analogue scale, and physical function, which was measured using qigong ( qì gōng) with motion. "Low-quality" evidence was found regarding the effects of acupuncture on physical function, and no evidence was found regarding the effects of herbal medicine on pain or physical function. Herbal patches ( yào bù) appeared to affect pain and physical and function, but these effects were not found to be significant. The initial findings included in this review suggest that acupuncture is a promising intervention according to the primary outcome measure, pain

  3. Studies on chemical protectors against radiation, 27; Survival effects of methanol extracts of various Chinese traditional medicines on radiation injury

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Cheng-Ming; Ohta, Setsuko; Shinoda, Masato (Hoshi Univ., Tokyo (Japan). Faculty of Pharmaceutical Science)

    1989-12-01

    The survival effect of mice irradiated with a lethal dose of X-ray was studied by use of 60 kinds of Chinese traditional medicines. Methanol extracts of these medicines were prepared, and then each extract injected intraperitoneally into male mice before or after whole-body irradiation. As a result of these studies, the survival effects with Ogi-kentyu-to, Simotu-to, Sessyo-in, Zokumei-to and Boi-ogi-to were observed by intraperitoneal injection before irradiation. Of these effective methanol extracts, only Zokumei-to was shown to have a significant survival effect by intraperitoneal injection after irradiation. (author).

  4. Vietnamese traditional medicine from a pharmacist's perspective

    NARCIS (Netherlands)

    Woerdenbag, H.J.; Nguyen, T.M.; Vu, D.V.; Tran, H.; Nguyen, D.T.; Tran, T.V.; De Smet, P.A.; Brouwers, J.R.

    2012-01-01

    Traditional medicine plays an important role in the healthcare system of Vietnam. Vietnamese traditional medicine (VTM) is underpinned by the oriental philosophy and theory of healing. VTM is largely influenced by traditional Chinese medicine, but differs to a certain extent. VTM is largely not evid

  5. Utilization pattern of traditional Chinese medicine for liver cancer patients in Taiwan

    Directory of Open Access Journals (Sweden)

    Liao Yueh-Hsiang

    2012-09-01

    Full Text Available Abstract Background Traditional Chinese Medicine (TCM is one of the most popular complementary and alternative medicine modalities worldwide. In Chinese and East Asian societies, TCM plays an active role in the modern health care system and is even covered by the National Health Insurance Program of Taiwan. Liver cancer is the second most common cancer in Taiwan. This study aimed to analyze the TCM utilization patterns of patients with liver cancer from 1996–2007 using a population-based random sample of one million insured patients. Methods A cross-sectional study was conducted using registration and claim data sets from 1996 to 2007 obtained from the Longitudinal Health Insurance Database 2005 (LHID2005. The outpatient datasets contained the encounter form-based dates of visit, three items from the International Classification of Diseases (Ninth Revision, Clinical Modification codes, the primary procedure (e.g., drug or diagnostic procedure, type of copayment, billed amount, and paid amount. Only ambulatory care was analyzed. Results A total of 6358 liver cancer patients utilized ambulatory care during the study period. Among them, 1240 (19.50% availed of TCM outpatient services. The prevalence of TCM use fluctuated during the study period, with a peak of 25.11% in 2001. After multivariable adjustment, the likelihood of TCM users was lower in participants aged 70 years and older (odds ratio, OR = 0.79, 95% confidence interval, CI: 0.64–0.97, males (OR = 0.60, 95% CI: 0.52–0.68, residents of Taipei (OR = 0.75, 95% CI: 0.58–0.96 as well as farmers and fishermen (OR = 0.71, 95% CI: 0.54–0.94, but was higher in residents of central Taiwan (OR = 1.99, 95% CI: 1.56–2.54. Most biomedicine and TCM outpatient services were provided by private clinics, followed by private hospitals. The two most frequently recorded coexisting diseases for both biomedicine and TCM outpatient visits specifically for liver cancer were (1

  6. Research on curative effect of traditional Chinese medicine treating low-grade fever of children caused by respiratory system infection.

    Science.gov (United States)

    Li, Xiangyun

    2015-07-01

    This study aims to explore the curative effect of traditional Chinese medicine treating low-grade fever of children caused by respiratory system infection. Sixty children who suffered low-grade fever caused by respiratory system infection were selected and divided into treatment group and control group randomly, each with 30 cases. Control group was treated with conventional methods including oxygen uptake, nebulization and anti-infection, etc, while treatment group was given boil-free granules of traditional Chinese medicine besides the treatment which control group received. Then clinical curative effect of two groups was compared. Results showed that 28 cases (93.3%) were cured in treatment group; while 21 cases (70.0%) were cured in control group. Compared with control group, the treatment group showed up better treatment efficiency and the difference between groups was of statistical significance (Pfever of children caused by respiratory system infection; characterized by short treatment cycle and effective treatment effect, Chinese medicine granules in the combination with oxygen atomization inhalation is proved to be able to efficiently remit symptoms such as coughing, gasp and labored breathing, with outstanding curative effect in the treatment of low-grade fever of children caused by respiratory system infection, thus it is worthy of popularization and application clinically.

  7. Thinking on Treatment of Post-reperfusion Events in Patients with Coronary Heart Disease by Integrated Traditional Chinese and Western Medicine

    Institute of Scientific and Technical Information of China (English)

    SHI Zai-xiang

    2007-01-01

    @@ In the 1970's,promoting blood circulation to remove blood stasis (PCRS) was the main method in integrative traditional Chinese and Western medicine(ICWM)in treating acute myocardial infarction(AMI).

  8. 2 The Diagnosis and Treatment Using Japanese Traditional Medicine in Vertiginous Patients(Chinese Herb Medicine Therapy in Surgical Fields)

    OpenAIRE

    関, 聡; Seki, Satoshi

    2006-01-01

    Japanese traditional medicine was applied to clarify the pathogenesis of vertiginous patients. It is suggested that psychogenic factor plays an important role in the occurrence of vertigo, multiple factors may contribute to the occurrence of vertigo, and vascular disorder is may be related to the occurrence of vertigo unknown origin using Ki-Ketsu-Sui. It is also speculated that Japanese traditional medical diagnosis will help us to understand the pathology of the chronic stage in vertigo by ...

  9. 中医学的非实体性思维%The non-substantive thought of traditional Chinese medicine

    Institute of Scientific and Technical Information of China (English)

    宁泽晖; 王华生

    2012-01-01

    Western medicine grasps the object world by analyzing the various factors of the whole, and recourse the sub -stantive being that decides life state of person. By researching the relations of the various factors in the inside and outside environment of person's vital activity, traditional Chinese medicine investigates the coupling and function of the various fac -tors, and probes the interaction that causes the biological of person. To the substantive thought of Western medicine, it is distinct contrast that the non-substantive thought of traditional Chinese medicine that pays attention to the relations and in -teraction of the organism.%西医学从整体中各要素的分析入手来把握对象世界,追索决定人的生命状态的实体性存在.中医学从人的生命活动的内外环境中诸要素的关系入手,考察各要素的联结及其功能,探究导致人的生命现象产生的相互作用.中医学重视有机体的关系与相互作用的非实体性思维,与西医学的实体性思维形成了鲜明的对照.

  10. Effect of Traditional Chinese Medicine on Inflammatory Mediators in Pediatric Asthma

    Directory of Open Access Journals (Sweden)

    Hui Du

    2016-01-01

    Full Text Available Objective. To observe the effects of empirical prescriptions of traditional Chinese medicine (TCM on inflammatory mediators in pediatric asthma and to explore the underlying molecular mechanism in the treatment of asthma. Methods. A total of 182 children with asthma were randomly placed into either the TCM group (n=97 or the salbutamol and montelukast (SM group (n=85. Patients in the TCM group were treated with a series of empirical prescriptions of TCM, while those in the SM group received salbutamol and montelukast. Both groups received their respective treatment for 12 weeks. There were 35 patients in TCM group and 34 patients in SM group providing venous blood. Real-time PCR was used to determine the mRNA expression levels of interleukin- (IL- 10, IL-17, matrix metalloproteinase-9 (MMP-9, and transforming growth factor β1 (TGF-β1 in peripheral blood mononuclear cells before and after treatment. Enzyme-linked immunosorbent assay was used to measure the levels of IL-10, IL-17, MMP-9, and TGF-β1 in peripheral blood before and after treatment. Results. The mRNA expression of TGF-β1 in the SM group was downregulated (P=0.00 after treatment. No significant differences were found between the TCM group and the SM group after treatment (P>0.05. In the TCM group, the levels of IL-10, IL-17, and MMP-9 significantly decreased after treatment (P=0.01, 0.04, and 0.03, resp.. In the SM group, IL-17, MMP-9, and TGF-β1 levels significantly decreased after treatment (P=0.00, 0.03, and 0.00, resp.. There was no significant difference between the two groups regarding the levels of IL-10, IL-17, TGF-β1, and MMP-9 (P>0.05. The difference of the level of IL-17 was negatively correlated with the change of C-ACT score in TCM group and SM group. Conclusion. TCM has a regulatory effect on the balance of some inflammatory mediators in pediatric asthma.

  11. Type Two Cytokines Predominance of Human Lung Cancer and Its Reverse by Traditional Chinese Medicine TTMP

    Institute of Scientific and Technical Information of China (English)

    HaimingWei; RuiSun; WeiXiao; JinboFeng; ChunyanZhen; XiaoqunXu; ZhigangTian

    2004-01-01

    Type 2 cytokines are usually predominant in tumor patients and associated with tumor progression. To explore whether reversing of type 2 predominance could be a promising strategy in tumor immunotherapy, PBMCs of 35 lung cancer patients and 19 healthy subjects were prepared and subjected to be examined for cytokine secretion and gene expression. Tetra-Methylpyrazine (TTMP), extracted from a traditional Chinese medicinal herb which has been used in clinic to reverse the Th2 status of cancer patients in China, was added to PBMC culture. Determined by RT-PCR, the positive percentages of mRNA expression of type 1 cytokines (8.6% for IFN-γ and 11.4% for IL-2) were lower than those of type 2 cytokines (71.4% for IL-4, 60% for IL-6 and 80% for IL-10) in patients' PBMCs. The potential of gene expressing (measured as relative intensity to the ratio of β-actin) in the patients for type 1 cytokines was also in a low level (0.111 for IFN-γ, 0.119 for IL-2) in comparison with a relative high level for type 2 cytokines (0.319 for IL-4, 0.303 for IL-6 and 0.377 for IL-10). Meanwhile, both positive percentage and relative intensity of gene expression were lower for a type 1 cytokine-related transcription factor T-bet (31.4% and 0.142, respectively) than those for type 2 cytokine-related GATA3 (85.7% and 0.378, respectively). The blood serum levels of IFN-7 and IL-2 in the patients were slightly lower but not significantly when compared with healthy control. In contrast, the levels IL-4 and IL-6 in patients were significantly higher than those in healthy subjects by ELISA analysis. TTMP could enhance supernatant concentration and gene expression levels of IFN-γ, IL-2 and T-bet, but reduced those of type 2 cytokines. These results demonstrate that the lung cancer patients had a predominant expression of type 2 cytokines and TTMP could reverse the type 2 dominant status, which might offer an alternative therapeutic regime for lung cancer patients. Cellular & Molecular Immunology

  12. Type Two Cytokines Predominance of Human Lung Cancer and Its Reverse by Traditional Chinese Medicine TTMP

    Institute of Scientific and Technical Information of China (English)

    Haiming Wei; Rui Sun; Wei Xiao; Jinbo Feng; Chunyan Zhen; Xiaoqun Xu; Zhigang Tian

    2004-01-01

    Type 2 cytokines are usually predominant in tumor patients and associated with tumor progression. To explore whether reversing of type 2 predominance could be a promising strategy in tumor immunotherapy, PBMCs of 35 lung cancer patients and 19 healthy subjects were prepared and subjected to be examined for cytokine secretion and gene expression. Tetra-Methylpyrazine (TTMP), extracted from a traditional Chinese medicinal herb which has been used in clinic to reverse the Th2 status of cancer patients in China, was added to PBMC culture.Determined by RT-PCR, the positive percentages of mRNA expression of type 1 cytokines (8.6% for IFN-γ and 11.4% for IL-2) were lower than those of type 2 cytokines (71.4% for IL-4, 60% for IL-6 and 80% for IL-10) in patients' PBMCs. The potential of gene expressing (measured as relative intensity to the ratio of β-actin) in the patients for type 1 cytokines was also in a low level (0.111 for IFN-γ, 0.119 for IL-2) in comparison with a relative high level for type 2 cytokines (0.319 for IL-4, 0.303 for IL-6 and 0.377 for IL-10). Meanwhile, both positive percentage and relative intensity of gene expression were lower for a type 1 cytokine-related transcription factor T-bet (31.4% and 0.142, respectively) than those for type 2 cytokine-related GATA3 (85.7% and 0.378,respectively). The blood serum levels of IFN-γ and IL-2 in the patients were slightly lower but not significantly when compared with healthy control. In contrast, the levels IL-4 and IL-6 in patients were significantly higher than those in healthy subjects by ELISA analysis. TTMP could enhance supernatant concentration and gene expression levels of IFN-γ, IL-2 and T-bet, but reduced those of type 2 cytokines. These results demonstrate that the lung cancer patients had a predominant expression of type 2 cytokines and TTMP could reverse the type 2 dominant status, which might offer an alternative therapeutic regime for lung cancer patients. Cellular & Molecular Immunology

  13. Age, chronic non-communicable disease and choice of traditional Chinese and western medicine outpatient services in a Chinese population

    Directory of Open Access Journals (Sweden)

    Yeoh Eng

    2009-11-01

    Full Text Available Abstract Background In 1997 Hong Kong reunified with China and the development of traditional Chinese medicine (TCM started with this change in national identity. However, the two latest discussion papers on Hong Kong's healthcare reform have failed to mention the role of TCM in primary healthcare, despite TCM's public popularity and its potential in tackling the chronic non-communicable disease (NCD challenge in the ageing population. This study aims to describe the interrelationship between age, non-communicable disease (NCD status, and the choice of TCM and western medicine (WM services in the Hong Kong population. Methods This study is a secondary analysis of the Thematic Household Survey (THS 2005 dataset. The THS is a Hong Kong population representative face to face survey was conducted by the Hong Kong Administrative Region Government of China. A random sample of respondents aged >15 years were invited to report their use of TCM and WM in the past year, together with other health and demographic information. A total of 33,263 persons were interviewed (response rate 79.2%. Results Amongst those who received outpatient services in the past year (n = 18,087, 80.23% only visited WM doctors, 3.17% consulted TCM practitioners solely, and 16.60% used both type of services (double consulters. Compared to those who only consulted WM doctor, multinomial logistic regression showed that double consulters were more likely to be older, female, NCD patients, and have higher socioeconomic backgrounds. Further analysis showed that the association between age and double consulting was curvilinear (inverted U shaped regardless of NCD status. Middle aged (45-60 years NCD patients, and the NCD free "young old" group (60-75 years were most likely to double consult. On the other hand, the relationship between age and use of TCM as an alternative to WM was linear regardless of NCD status. The NCD free segment of the population was more inclined to use TCM alone

  14. [Rapid screening and quality evaluation for the harmful substance 5-hydroxymethyl furfural in commercially available traditional Chinese medicine injection using LC-MS/MS method].

    Science.gov (United States)

    Zang, Qing-ce; He, Jing-jing; Bai, Jin-fa; Zheng, Ya-jie; Zhang, Rui-ping; Li, Tie-gang; Wang, Zhong-hua; He, Jiu-ming; Abliz, Zeper

    2013-11-01

    To screen the harmful substance 5-hydroxymethyl furfural content in commercially available traditional Chinese medicine injection which are commonly used, and to preliminarily evaluate the quality of these injections, 5-hydroxymethyl furfural was taken as an index. The contents of 5-hydroxymethyl furfural in 56 samples which consist of 23 kinds of traditional Chinese medicine injections and glucose injection were determined using LC-MS/MS, and 5-hydroxymethyl furfural was detected in 52 of these samples. The minimal content was 0.0038 microg x L(-1) and the maximum content was 1420 microg x mL(-1). The contents of 5-hydroxymethyl furfural were significantly different in traditional Chinese medicine injection which came from different kinds, manufacturers or batches. The results showed the quality difference of commercially available traditional Chinese medicine injection is significant taking 5-hydroxymethyl furfural content as assessment index. More attention should be paid to the safety of 5-hydroxymethyl furfural in traditional Chinese medicine injection, and unified limitation standard should be set to improve medication safety of traditional Chinese medicine injection.

  15. Teaching Reform of Experimental Analysis of Traditional Chinese Medicine%中药分析实验教学改革

    Institute of Scientific and Technical Information of China (English)

    王磊; 严方; 汪丽霞; 宋瑞; 狄斌

    2014-01-01

    根据中药分析的学科发展和药学人才培养的趋势,结合该课程自身的特点,对中药分析实验教学内容、教学模式和考核方式进行改革,对培养学生的创新能力起到一定作用。%According to the trend of the Analysis of Traditional Chinese Medicine development and pharmaceutical talents training,and combining with the course of its own characteristics ,the teaching contents,models and assess-ment of the Experimental Analysis of Traditional Chinese Medicinewere reformed and practiced .The new innovative teaching method plays a role in improving the innovation ability of students.

  16. Study on Graded Therapy of Hemophilic Arthritis by Integrative Traditional Chinese and Western Medicine

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Objective:To study the effect and safety of graded therapy featuring integrative traditional Chinese and Western medicine for the treatment of hemophilic arthritis.Methods:Forty patients with hemophilic arthritis were hospitalized randomly,with their blood coagulation factor activity determined by one-stage method and their arthritis classified into 4 stages.The treatment was applied according to the stage of arthritis and finding of intra-articular cavity puncture.For stage Ⅰ,based on the principle of RICE(rest,ice,compression and elevation),1.8 g of Xuefuda(血府达)was medicated orally once per day,intravenous dripping of 250 mL of hemostasis mixture twice a day and 1.2 g of clindamycin per day were also given for hemostasis and anti-inflammation.For stage Ⅱ-Ⅲ,Kangyanling(抗炎灵)was additionally administered via intra-articular cavity injection twice a week,2 mL every time,for 5-6 times in total.For stage Ⅳ,the drug for intra-articular cavity injection was replaced with 25 mg of sodium hyaluronate and the frequency of injection reduced to every two weeks,for 5-6 times in total.Coagulation factors Ⅲ and 1V as well as blood plasma were not given in the whole treatment course.Short-term therapeutic effects and adverse reaction in patients were evaluated,and the long-term effects were followed-up after patients left the hospital with 6-month consolidation therapy by Xuefuda.Results:After a 3-week treatment,33 patients (82.5%)were completely remitted;5(12.5%)were partially remitted and 2(5.0%)un-remitted,setting the short-term effective rate at 95.0%(38 cases).The 6-month follow-up showed that except for a relapse in 2 and 4 patients of stage Ⅲ and Ⅳ respectively,long-term remission displayed in all the other 34 patients,with the remission sustaining rate being 85.0%.No complication such as an infection,bleeding or aggravating pain occurred in the 215 times intra-articular puncturing conducted in the 40 patients.Normal figures were shown in liver

  17. Developing an Activity and Absorption-based Quality Control Platform for Chinese Traditional Medicine: Application to Zeng-Sheng-Ping

    Science.gov (United States)

    Yin, Taijun; Yang, Guanyi; Ma, Yong; Xu, Beibei; Hu, Ming; You, Ming; Gao, Song

    2015-01-01

    Ethnopharmacological relevance Zeng-Sheng-Ping (ZSP) is a marketed Chinese traditional medicine used for cancer prevention. Aim of the study Currently, for the quality control of Chinese traditional medicines, marker compounds are not selected based on bioactivities and pharmaceutical behaviors in most of the cases. Therefore, even if the “quality” of the medicine is controlled, the pharmacological effect could still be inconsistent. The aim of this study is to establish an activity and absorption-based platform to select marker compound(s) for the quality control of Chinese traditional medicines. Materials and methods We used ZSP as a reference Chinese traditional medicine to establish the platform. Activity guided fractionation approach was used to purify the major components from ZSP. NMR and MS spectra were used to elucidate the structure of the isolated compounds. MTT assay against oral carcinoma cell line (SCC2095) was performed to evaluate the activities. UPLC-MS/MS was used to quantify the pure compounds in ZSP and the active fraction. The permeabilities of the identified compounds were evaluated in the Caco-2 cell culture model. The intracellular accumulation of the isolated compounds was evaluated in the SCC2095 cells. Results The major compounds were identified from ZSP. The contents, anti-proliferation activities, permeabilities, and intracellular accumulations of these compounds were also evaluated. The structure of these purified compounds were identified by comparing the NMR and MS data with those of references as rutaevine (1), limonin (2) , evodol (3), obacunone (4), fraxinellone (5), dictamnine (6), maackiain (7), trifolirhizin (8), and matrine (9). The IC50 of compounds 5, 6, and 7 against SCC2095 cells were significantly lower than that of ZSP. The uptake permeability of compounds 5, 6, and 7 were 2.58 ± 0. 3 × 10−5, 4.33 ± 0.5 × 10−5, and 4.27 ± 0.8 × 10−5 respectively in the Caco-2 cell culture model. The intracellular

  18. Development of Information Database of Traditional Chinese Medicine%与时俱进的中医药信息数据库

    Institute of Scientific and Technical Information of China (English)

    邱彤

    2009-01-01

    数据库系统在中医领域已建立了中医药现代期刊文献数据库、中医药古籍文献数据库、老中医经验和各种疾病的临床数据库等.中医药共享数据库的建立,成为中医药全面继承和创新的基础.%The research and establishment for the internet and information digitalization of traditional Chinese medicine have been greatly developed in the past thirty years, keeping paces with times. The database system has been extensively applied in the field of traditional Chinese medicine. The establishment of sharing databases for Chinese medicine will lay the foundation for inheritance and innovation of traditional Chinese medicine.

  19. Computer-assisted lip diagnosis on traditional Chinese medicine using multi-class support vector machines

    Directory of Open Access Journals (Sweden)

    Li FuFeng

    2012-08-01

    Full Text Available Abstract Background In Traditional Chinese Medicine (TCM, the lip diagnosis is an important diagnostic method which has a long history and is applied widely. The lip color of a person is considered as a symptom to reflect the physical conditions of organs in the body. However, the traditional diagnostic approach is mainly based on observation by doctor’s nude eyes, which is non-quantitative and subjective. The non-quantitative approach largely depends on the doctor’s experience and influences accurate the diagnosis and treatment in TCM. Developing new quantification methods to identify the exact syndrome based on the lip diagnosis of TCM becomes urgent and important. In this paper, we design a computer-assisted classification model to provide an automatic and quantitative approach for the diagnosis of TCM based on the lip images. Methods A computer-assisted classification method is designed and applied for syndrome diagnosis based on the lip images. Our purpose is to classify the lip images into four groups: deep-red, red, purple and pale. The proposed scheme consists of four steps including the lip image preprocessing, image feature extraction, feature selection and classification. The extracted 84 features contain the lip color space component, texture and moment features. Feature subset selection is performed by using SVM-RFE (Support Vector Machine with recursive feature elimination, mRMR (minimum Redundancy Maximum Relevance and IG (information gain. Classification model is constructed based on the collected lip image features using multi-class SVM and Weighted multi-class SVM (WSVM. In addition, we compare SVM with k-nearest neighbor (kNN algorithm, Multiple Asymmetric Partial Least Squares Classifier (MAPLSC and Naïve Bayes for the diagnosis performance comparison. All displayed faces image have obtained consent from the participants. Results A total of 257 lip images are collected for the modeling of lip diagnosis in TCM. The

  20. 中药现代化建设成果及思考%Achievements and Considerations on Modernization of Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    李冬雪

    2015-01-01

    从政策环境、中药现代化科技产业基地、新药研发、中医药标准、中药产业和中药国际化等方面回顾总结了我国中药现代化建设取得的主要成果,并在此基础上提出了“加强创新体系建设,以创新求发展”“加强产学研联盟,促进中医药成果的转化”和“着力发展大中药产业,实现科技惠民”三点思考,为广大中医药科技工作者提供参考.%This paper reviews and summaries the achievements on Modernization of Traditional Chinese Medicine,from the policy environment,the modernization of traditional Chinese medicine science and technology industrial base,research and development of new drugs,standard of traditional Chinese medicine,traditional Chinese medicine industry and internationalization of traditional Chinese medicine etc.And on this basis,the author put forward three points about implementation,"strengthening the construction of innovation system for innovation and development","strengthening alliances and promoting the transformation of traditional Chinese medicine" and "focus on the development of large industry of traditional Chinese medicine for technology for the benefit of the public",to provide reference for Chinese medical staffs.

  1. [Interaction between CYP450 enzymes and metabolism of traditional Chinese medicine as well as enzyme activity assay].

    Science.gov (United States)

    Lu, Tu-lin; Su, Lian-lin; Ji, De; Gu, Wei; Mao, Chun-qin

    2015-09-01

    Drugs are exogenous compounds for human bodies, and will be metabolized by many enzymes after administration. CYP450 enzyme, as a major metabolic enzyme, is an important phase I drug metabolizing enzyme. In human bodies, about 75% of drug metabolism is conducted by CYP450 enzymes, and CYP450 enzymes is the key factor for drug interactions between traditional Chinese medicine( TCM) -TCM, TCM-medicine and other drug combination. In order to make clear the interaction between metabolic enzymes and TCM metabolism, we generally chose the enzymatic activity as an evaluation index. That is to say, the enhancement or reduction of CYP450 enzyme activity was used to infer the inducing or inhibitory effect of active ingredients and extracts of traditional Chinese medicine on enzymes. At present, the common method for measuring metabolic enzyme activity is Cocktail probe drugs, and it is the key to select the suitable probe substrates. This is of great significance for study drug's absorption, distribution, metabolism and excretion (ADME) process in organisms. The study focuses on the interaction between TCMs, active ingredients, herbal extracts, cocktail probe substrates as well as CYP450 enzymes, in order to guide future studies.

  2. 中西医学术分野的焦点和分野点%Academic Focus and Dividing Line of Traditional Chinese Medicine and Western Medicine

    Institute of Scientific and Technical Information of China (English)

    祝世讷

    2016-01-01

    中医与西医的学术差异有微观和宏观两个层次,宏观差异是学术视野的分异,是整体性和根本性的差异.以欧氏几何与非欧几何为例,论证了中西医学术的分野是两圆相交式,即局部相交,主体相异,核心并立,方向相悖.指出了中西医学术分野的一个焦点——是否以人为本;剖析了中西医学术的四个分野点——人与人体之分、还原与非还原之分、生态与理化之分、临床研究与实验研究之分. 总结了中西医学术分野的两个基本特征——中医视野宽广但深细不足,西医视野缩减而深细.%The acadimic differences of traditional Chinese medicine and western medicine can be divided into micro and macro levels. The macro difference is the differentiation of academic views and it is an in-tegrity and fundamental difference. Based on Euclidean geometry and non-Euclidean geometry,the author demonstrates that the division of the research fields of the two medical systems is like two intersecting cir-cles. They belong to different subjects and partly intersect. Their cores exist side by side and their direc-tions are contrary to each other. Whether based on human being is the focus of the academic division of traditional Chinese medicine and western medicine. The paper analyzes the four division points of the two medical systems:the differences between body and human being,the differences between reduction and non-reduction,the differences between bionomics and physiclhemical and the differences between clinical re-search and experimental research. The two basic academic characteristics of traditional Chinese medicine and western medicine are summarized:the research field of traditional Chinese medicine is broad but not deep and the research field of western medicine is deep but not broad.

  3. [Discussion on research and development of new traditional Chinese medicine preparation process based on idea of QbD].

    Science.gov (United States)

    Feng, Yi; Hong, Yan-Long; Xian, Jie-Chen; Du, Ruo-Fei; Zhao, Li-Jie; Shen, Lan

    2014-09-01

    Traditional processes are mostly adopted in traditional Chinese medicine (TCM) preparation production and the quality of products is mostly controlled by terminal. Potential problems of the production in the process are unpredictable and is relied on experience in most cases. Therefore, it is hard to find the key points affecting the preparation process and quality control. A pattern of research and development of traditional Chinese medicine preparation process based on the idea of Quality by Design (QbD) was proposed after introducing the latest research achievement. Basic theories of micromeritics and rheology were used to characterize the physical property of TCM raw material. TCM preparation process was designed in a more scientific and rational way by studying the correlation among enhancing physical property of raw material, preparation process and product quality of preparation. So factors affecting the quality of TCM production would be found out and problems that might occur in the pilot process could be predicted. It would be a foundation for the R&D and production of TCM preparation as well as support for the "process control" of TCMIs gradually realized in the future.

  4. Discovering treatment pattern in Traditional Chinese Medicine clinical cases by exploiting supervised topic model and domain knowledge.

    Science.gov (United States)

    Yao, Liang; Zhang, Yin; Wei, Baogang; Wang, Wei; Zhang, Yuejiao; Ren, Xiaolin; Bian, Yali

    2015-12-01

    In Traditional Chinese Medicine (TCM), the prescription is the crystallization of clinical experience of doctors, which is the main way to cure diseases in China for thousands of years. Clinical cases, on the other hand, describe how doctors diagnose and prescribe. In this paper, we propose a framework which mines treatment patterns in TCM clinical cases by exploiting supervised topic model and TCM domain knowledge. The framework can reflect principle rules in TCM and improve function prediction of a new prescription. We evaluate our method on 3090 real world TCM clinical cases. The experiment validates the effectiveness of our method.

  5. Progress in the Treatment of Vertigo With Traditional Chinese Medicine%眩晕中医辨治进展

    Institute of Scientific and Technical Information of China (English)

    李志

    2009-01-01

    总结了近5年来中医对眩晕的病因病机研究概况及从脏腑论治(肝、肾、脾、胃、肺)眩晖的研究进展,以期对临床治疗眩晕提供辨证思路及方法.%It was summarized that the progress on etiological factors and pathogenesis of vertigo, treatment from five viscera based on recent five years literatures. That supplied some thinking way and method for the treatment of vertigo with traditional Chinese medicine.

  6. [Key technologies elements of clinical study of traditional Chinese medicine new drugs on children's dermatitis and eczema].

    Science.gov (United States)

    Zhong, Cheng-Liang; Zhang, Chun; Hu, Si-Yuan

    2013-06-01

    We assessed and graded the evidence of relevant systematic reviews and randomized controlled trials, combined with our clinical study practice to identify eleven key elements as a focus for the clinical study of traditional Chinese medicine (TCM) new drugs on children's dermatitis and eczema: the primary purpose and design of the study, the inclusion and exclusion criteria of the study, the treatment, the trail procedure,the effectiveness and safety evaluation, and quality control, etc, as well. In addition, seven recommendations for the design of clinical study of TCM new drugs on children's dermatitis and eczema were provided.

  7. Study of the Relationship between Carotid Intima-media Thickness and Traditional Chinese Medicine Syndrome of Dyslipidemia

    Institute of Scientific and Technical Information of China (English)

    雷燕; 王振华; 赵浩; 刘剑刚

    2009-01-01

    Objective:The study aimed to explore the relationship between the carotid intima-media thickness (IMT),lipids,high-sensitivity C-reactive protein(hs-CRP),homocysteine(Hcy) and other indices of laboratory and the traditional Chinese medicine(TCM) syndrome of dyslipidemia.Methods:A total of 152 dyslipidemia patients and 8 healthy people(taken as the control group) were recruited.According to the theory of the TCM syndrome,152 dyslipidemia patients were assigned to 4 groups:the stagnation of phlegm(SP) grou...

  8. Traditional Chinese Medicine Diagnosis and Evaluation of the Clinical Effect in Post-hepatitic Cirrhosis based on Fuzzy Analysis

    Institute of Scientific and Technical Information of China (English)

    ZHANG Hao-wei; ZHU Xun-sheng

    2008-01-01

    In view of the problem of traditional Chinese medicine (TCM) diagnosis, fuzzy comprehensive evaluation is introduced to the diagnosis and evaluation of the clinical effect of hepatitis. A new diagnosis and evaluation model of the TCM clinical effect standard was presented. The old disputed evaluation model by subjective analysis can be displaced by this objective method in its evaluation system. The foundation of this method is the fuzzy diagnosis model. This method has been realized to diagnose hepatitis and its values in practice has been validated through examples of clinical syndromes of post-hepatitic cirrhosis.

  9. [Study on medical pattern of traditional Chinese medicine and western medicine diagnosis and treatment of hypertension patients in 30 034 cases in real world].

    Science.gov (United States)

    Ma, Jin-hui; Wang, Zhi-fei; Xie, Yan-ming; Yang, Wei; Yang, Zhi-xin; Zhuang, Yan; Wang, Yong-yan

    2014-09-01

    Select patients diagnosed of hypertension in the first place in 16 hospitals and the patients were described by association rules analysis and distribution for the analysis in the study,in order to understand the information of diagnosis and treatment in hypertension patients in real world. The information include age, gender, admission condition, inpatient department, hospitalization expenses, western medicine comorbidities, the traditional Chinese medicine (TCM) syndrome and the medicine. The average age of patients was 64 years in the study. The proportion of men to women about 1. 10: 1. Admission condition is critical for about 10.12% of the total and more concentrated in the cardiovascular department. Hospital stay ranged from 8 to 14 d. Inpatients with medical insurance is 62.93%. Total hospitalization cost distribution most is the 5 000-10 000 RMB. Hypertension complicated with coronary heart disease, blood lipoprotein disorder disease; phlegm and blood stasis and Yin deficiency of liver and kidney are the most in TCM syndrome type. Promoting blood circulation and removing blood stasis is the major in Chinese medicine treatment. Western medicine treatment basically conforms to the guidelines. The most antihypertensive drugs is calcium antagonistst, accounting for about 81.2% of the total number. Class ACEI, class ARB, beta blockers, diuretics class are accounted for 43.0%, 43.4%, 42.4%, 42.4%, fixed compound is only 2 393, accounting for about 8%. the total frequency of five classes of antihypertensive drugs is 78 206 times. The principal conclusions of this analysis are as follows: the elderly people is the most in hypertension, more men than women; medical insurance is the majority type in hospitalization cost; nearly half of the population is combined with coronary heart disease; phlegm and blood stasis and yin deficiency of liver and kidney are the most in TCM syndrome type; western medicine treatment basically conforms to the guidelines. Combination

  10. Epigenetic regulations of hematopoietic stem cells ageing and the regulation of traditional Chinese medicine

    Institute of Scientific and Technical Information of China (English)

    Dao-Zheng Yang; Xin-Yuan Luan; Shu-Bin Wang

    2016-01-01

    因为衰老而导致的干细胞功能缺陷会影响组织的稳态,并最终导致机体寿命缩短。干细胞具有自我更新和增殖分化能力,在机体生长发育过程中对组织的自我修复及再生无疑是至关重要的。成体干细胞中研究比较透彻的干细胞是造血干细胞(HSCs),但是对其自身衰老调控的机制尚不清楚。表观修饰的改变被认为是哺乳动物衰老的标志之一,并且参与了HSCs 的衰老过程。另外,近期的研究发现HSCs 的衰老与血液肿瘤密切相关,因此表观遗传调控者或许可以成为治疗血液肿瘤的新靶点。长久以来中药一直被用于治疗血液肿瘤并且疗效确切,比如三氧化二砷。在这篇综述中,我们总结了表观修饰改变与HSCs 衰老的关系,并且重点论述了DNA 甲基化及组蛋白修饰调控HSCs 衰老的机制。我们还总结了目前用于治疗血液肿瘤的部分中药,并对其表观遗传调控的角色进行了论述,旨在为开发新的药物提供依据。%Age-related defects in stem cells can limit proper tissue maintenance and hence contribute to a shortened lifespan. Given the essential role of a stem cell to self-renew, differentiate, and proliferate, it is no wonder that they are critically important to an organism during development and to tissue self-healing and regeneration. Hematopoietic stem cells (HSCs), as one of adult stem cells, have been well characterized recently. However, the regulation mechanism of HSCs ageing remains unclear. Epigenetic alterations are now recognized as a hallmark of mammalian ageing and involved in HSCs ageing. In addition, recent studies showed that HSCs ageing is related to hematological malignancies. Therefore, epigenetic modifiers maybe novel targets for hematological malignancies therapy. Traditional Chinese medicine (TCM) has been used to treat hematological malignancies for centuries. Here, we aim to review the current progress in the

  11. The importance of translation of traditional Chinese medicine from the perspective of international communication of traditional Chinese medicine culture%中医药文化国际传播视角下看中医翻译的重要性

    Institute of Scientific and Technical Information of China (English)

    马平

    2013-01-01

    This paper mainly in the perspective of international communication, through the advantages of international communication of traditional Chinese medicine culture and present situation of translation of traditional Chinese medicine culture, points out the importance of Chinese translation, and then put forward that the translation of traditional Chinese medicine plays a crucial role for the international dissemination of traditional Chinese medicine culture.%本文主要在国际传播视角下,通过阐释中医药文化国际传播的优势及分析中医翻译的现状,指出了中医翻译的重要性,进而提出了中医翻译对中医药文化的国际传播具有至关重要的作用。

  12. Smart Soup, a traditional Chinese medicine formula, ameliorates amyloid pathology and related cognitive deficits.

    Directory of Open Access Journals (Sweden)

    Yujun Hou

    Full Text Available Alzheimer's disease (AD is a progressive neurodegenerative disease that causes substantial public health care burdens. Intensive efforts have been made to find effective and safe disease-modifying treatment and symptomatic intervention alternatives against AD. Smart Soup (SS, a Chinese medicine formula composed of Rhizoma Acori Tatarinowii (AT, Poria cum Radix Pini (PRP and Radix Polygalae (RP, is a typical prescription against memory deficits. Here, we assessed the efficacy of SS against AD. Oral administration of SS ameliorated the cognitive impairment of AD transgenic mice, with reduced Aβ levels, retarded Aβ amyloidosis and reduced Aβ-induced gliosis and neuronal loss in the brains of AD mice. Consistently, SS treatment reduced amyloid-related locomotor dysfunctions and premature death of AD transgenic Drosophila. Mechanistic studies showed that RP reduced Aβ generation, whereas AT and PRP exerted neuroprotective effects against Aβ. Taken together, our study indicates that SS could be effective against AD, providing a practical therapeutic strategy against the disease.

  13. A pilot study of phytoestrogen content of soy foods and traditional Chinese medicines for women's health in Hong Kong.

    Science.gov (United States)

    Li, Martin; Poon, Peter; Woo, Jean

    2004-05-01

    In view of the possible health benefits of phytoestrogens, a pilot study was carried out to quantitate the phytoestrogen content of soy foods and tea commonly consumed in Hong Kong, and also of traditional Chinese medicinal (TCM) products that are prescribed for menopausal symptoms and diseases relating to the menopause. Assays of daidzein and genistein were carried out using high-performance liquid chromatography, after extraction procedures. The TCM products were found to contain phytoestrogen in quantities comparable with soy products. Moreover, certain types of Chinese tea contained large quantities of phytoestrogens in the leaves, but also yielded comparable quantities in the infusion for drinking. The phytoestrogen content of these TCM may provide a scientific basis for their actions. However, clinical efficacy can only be determined by clinical trials.

  14. BioTCM-SE: a semantic search engine for the information retrieval of modern biology and traditional Chinese medicine.

    Science.gov (United States)

    Chen, Xi; Chen, Huajun; Bi, Xuan; Gu, Peiqin; Chen, Jiaoyan; Wu, Zhaohui

    2014-01-01

    Understanding the functional mechanisms of the complex biological system as a whole is drawing more and more attention in global health care management. Traditional Chinese Medicine (TCM), essentially different from Western Medicine (WM), is gaining increasing attention due to its emphasis on individual wellness and natural herbal medicine, which satisfies the goal of integrative medicine. However, with the explosive growth of biomedical data on the Web, biomedical researchers are now confronted with the problem of large-scale data analysis and data query. Besides that, biomedical data also has a wide coverage which usually comes from multiple heterogeneous data sources and has different taxonomies, making it hard to integrate and query the big biomedical data. Embedded with domain knowledge from different disciplines all regarding human biological systems, the heterogeneous data repositories are implicitly connected by human expert knowledge. Traditional search engines cannot provide accurate and comprehensive search results for the semantically associated knowledge since they only support keywords-based searches. In this paper, we present BioTCM-SE, a semantic search engine for the information retrieval of modern biology and TCM, which provides biologists with a comprehensive and accurate associated knowledge query platform to greatly facilitate the implicit knowledge discovery between WM and TCM.

  15. BioTCM-SE: A Semantic Search Engine for the Information Retrieval of Modern Biology and Traditional Chinese Medicine

    Directory of Open Access Journals (Sweden)

    Xi Chen

    2014-01-01

    Full Text Available Understanding the functional mechanisms of the complex biological system as a whole is drawing more and more attention in global health care management. Traditional Chinese Medicine (TCM, essentially different from Western Medicine (WM, is gaining increasing attention due to its emphasis on individual wellness and natural herbal medicine, which satisfies the goal of integrative medicine. However, with the explosive growth of biomedical data on the Web, biomedical researchers are now confronted with the problem of large-scale data analysis and data query. Besides that, biomedical data also has a wide coverage which usually comes from multiple heterogeneous data sources and has different taxonomies, making it hard to integrate and query the big biomedical data. Embedded with domain knowledge from different disciplines all regarding human biological systems, the heterogeneous data repositories are implicitly connected by human expert knowledge. Traditional search engines cannot provide accurate and comprehensive search results for the semantically associated knowledge since they only support keywords-based searches. In this paper, we present BioTCM-SE, a semantic search engine for the information retrieval of modern biology and TCM, which provides biologists with a comprehensive and accurate associated knowledge query platform to greatly facilitate the implicit knowledge discovery between WM and TCM.

  16. Study on Intranasal Administration of Traditional Chinese Medicine%中药经鼻腔给药研究

    Institute of Scientific and Technical Information of China (English)

    邬伟魁; 张海燕; 宋伟; 贺娅; 李芳; 郑琴; 杨明

    2011-01-01

    主要对中药经鼻腔给药研究进行文献整理和分析.研究表明,中药经鼻腔给药可以在鼻腔起局部治疗作用,或经鼻吸收后向脑内递药发挥中枢治疗作用,还可以起到治疗全身性疾病的作用.综述了近年来中药经鼻腔给药的实验研究及临床运用,主要包括鼻用制剂国内现状、中药经鼻腔给药基础实验研究(给药途径的选择、剂型的选择、辅料的选择、体外释药评价、药代动力学研究、药效学研究、脑靶向性、安全评价)、中药鼻用制剂的临床观察实例研究,并对其进行了展望,以期为中药经鼻腔给药临床疾病治疗应用和中药鼻用制剂新药开发提供参考.%The field of intranasal administration of traditional Chinese medicine is illustrated in this review article. Intranasal administration of traditional Chinese medicine has a local effect on nasal cavity,or delivered from nose to brain to show a centralnervons treatment as well as works in curing systemic diseases. This paper makes an overview of expenrimental study ( the route of administration, dosage form selection, the choice of excipients, evaluation of drug release in vitro, pharmacokinetics, pharmacodynaraics, brain targeting, safety evaluation ) and clinical applications on intranasal administration of Chinese Medicine in recent years and has a bright future, expecting to provide reference for new drug of intranasal preparation of traditional Chinese medicine.

  17. Traditional Chinese Medicine Treatment Progress of Post-stroke Dysphagia%卒中后吞咽障碍中医临床治疗进展

    Institute of Scientific and Technical Information of China (English)

    刘强; 薛伟伟

    2016-01-01

    In this paper,Chinese medicine treatment of post-stroke dysphagia literature analysis,the traditional Chinese medicine,acupuncture,Chinese medicine rehabilitation plays an important role in post-stroke dysphagia,and worthy of clinical application.%本文通过对卒中后吞咽障碍中医治疗文献分析,认为中药、针灸、中医康复训练在卒中后吞咽障碍中起着重要作用,值得临床应用.

  18. 慢性荨麻疹中医治疗概况%Profile of the treatment of chronic urticaria by Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    仲亚平; 闵仲生

    2014-01-01

    The literature of TCM treatment of chronic urticaria were summarized, and it pointed out that Traditional Chinese Medicine, integrated Chinese and western medicine, Chinese medicine external treatment methods had good curative effect on chronic urticaria.%对近年文献报道有关慢性荨麻疹中医治疗方法及进展进行综述,指出通过中药治疗、中西医结合、中医外治等方法治疗慢性荨麻疹可取的较好疗效。

  19. 中医在美国发展的概况%Development of traditional Chinese medicine in United States

    Institute of Scientific and Technical Information of China (English)

    田小明

    2012-01-01

    The United States government established Complementary and Alternative Medicine ( CAM ) to meet the public needs. In 1991 , the National Institutes of Health (NIH) approved the first acupuncture clinic for their patients. The National Center of Complementary and Alternative Medicine ( NCCAM ) was founded at NIH in 1998 to sponsor and develop CAM research. In 2001, the budget for NCCAM had grown to 130 million USD. Of the 3 300 papers on CAM published in the past ten years, 520 were funded by NIH. NCCAM goals are to focus on "mind and body medicine" and "herbals" for future research. Traditional Chinese medicine (TCM) is one of the major components in CAM. From 1998 to 2012, NCCAM funded 248 research subjects on TCM, with a total budget of 236 million USD. The subjects were as follows: 160 for acupuncture, 36 for Chinese medicine, 33 for Tai Chi, and 19 for Qigong. The American public is increasingly supportive of CAM, including TCM. According to the national survey in 2008 , nearly 40% of American used CAM, 11% of them were children, self-spending 33. 9 billion USD in 2007. In the same year, 3. 7 million people received acupuncture in the United States. The data also indicate that women, higher income and higher educated people used CAM more frequently. An increasing number of allopathic medical professionals are open to CAM, and recommend their patients to use acupuncture and other modalities. TCM, as an important part of CAM, has become a new option for patients in improving their healthcare services in conjunction with allopathic medicine. TCM will have more potential to be utilized in the United States.

  20. Clinical Observation on Treatment of 2,062 Cases of Immune Infertility with Integration of Traditional Chinese Medicine and Western Medicine

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    To study the therapeutic effect of integrated traditional Chinese medicine and western medicine on female immune infertility. 3,496 women suffering from primary or secondary infertility had their ASAb, EMAb,AOAb and ACAb level tested, with the positive rate of 23.11%, 34.95%, 20.77% and 30.41% respectively.2,062 positive cases were periodically treated with the Chinese drug Xiaokangwan (消抗丸) plus dexamethasone, vitamin E and vitamin C for 2 periods as a course of treatment. At the end of a treatment course, the rate for the antibodies to turn negative reached over 85% and the average pregnant rate reached 36.66%. The treatment of immune infertility with the integrated approach can reduce or eliminate the influence of antibodies in the serum of patients on various links of pregnancy, thus reaching the goal of curing infertility.

  1. Epidemiology characteristics, reporting characteristics, and methodological quality of systematic reviews and meta-analyses on traditional Chinese medicine nursing interventions published in Chinese journals.

    Science.gov (United States)

    Yang, Min; Jiang, Li; Wang, Aihong; Xu, Guihua

    2017-02-01

    To evaluate the epidemiological characteristics, reporting characteristics, and methodological quality of systematic reviews in the traditional Chinese medicine nursing field published in Chinese journals. The number of systematic reviews in the traditional Chinese medicine nursing field has increased, but their epidemiology, quality, and reporting characteristics have not been assessed completely. We generated an overview of reviews using a narrative approach. Four Chinese databases were searched for systematic reviews from inception to December 2015. The Preferred Reporting Items of Systematic Reviews and Meta-analyses and the Assessment of Multiple Systematic Reviews checklists were adopted to evaluate reporting and methodological quality, respectively. A total of 73 eligible systematic reviews, published from 2005 to 2015, were included. The deficiencies in reporting characteristics mainly lay in the lack of structured abstract or protocol, incomplete reporting of search strategies, study selection, and risk of bias. The deficiencies in methodological quality were reflected in the lack of a priori design and conflict of interest, incomplete literature searches, and assessment of publication bias. The quality of the evaluated reviews was unsatisfactory; attention should be paid to the improvement of reporting and methodological quality in the conduct of systematic reviews.

  2. Traditional Chinese medicine and the positive correlation with homeostatic evolution of human being: based on medical perspective.

    Science.gov (United States)

    Wang, Jie-Hua

    2012-08-01

    Adaptation is an eternal theme of biological evolution. The paper aims at exploring the conception of positive correlation between traditional Chinese medicine (TCM) and human homeostatic evolution based on medical perspective. Discussions mainly involve TCM conforming to natural laws and natural evolution of life, spontaneous harmonization of yin and yang and operating system of human self-healing, modern human immunology and human endogenous immune function in TCM, self-homeostasis of human micro-ecological state and balance mechanism on regulating base in TCM, as well as adaptation-eternal theme of biological evolution and safeguarding adaptability-value of TCM. In perspective of medicine, theory and practice of TCM are in positive correlation with human homeostatic evolution, and what TCM tries to maintain is human intrinsic adaptive capability to disease and nature. Therefore, it is the core value of TCM, which is to be further studied, explored, realized and known to the world.

  3. Static headspace-multicapillary column with gas chromatography coupled to ion mobility spectrometry as a simple approach for the discrimination of crude and processed traditional Chinese medicines.

    Science.gov (United States)

    Cao, Gang; Shou, Qiyang; Li, Qinglin; Jiang, Jianping; Chen, Xiaocheng

    2014-11-01

    The processing procedure can alter the nature and chemical transformation of traditional Chinese medicine to accommodate different clinical dispensing and preparation requirements. In this study, static headspace-multicapillary column with gas chromatography coupled to ion mobility spectrometry was developed for the rapid and sensitive discrimination of crude and processed traditional Chinese medicine. Using Radix Paeoniae Alba as a traditional Chinese medicine model, the combined power of this approach was illustrated by classifying the crude and processed Radix Paeoniae Alba samples into two main categories. The contents of the main components in Radix Paeoniae Alba varied significantly. The established method could promote the use of ion mobility spectrometry in intrinsic quality control and differentiation of herbal medicines from other processed products or preparations.

  4. 中药治疗骨质疏松进展%Progress of osteoporosis treatment with traditional Chinese medicine

    Institute of Scientific and Technical Information of China (English)

    邢燕; 田雪峰; 张倩楠; 刘忠厚

    2013-01-01

    骨质疏松症是多种病因单独或综合引起的一种全身代谢性疾病,以骨量减少、骨组织微观结构退化和骨的力学性能下降为特征.近年来,中药在对骨质疏松治疗方面的研究日益增多,并且也取得了一定进展.本文挑选了一些常用的中药骨碎补,淫羊藿,补骨脂,续断,杜仲,黄芪,巴戟天,鹿茸,丹参,附子.从传统的功能主治方面和现代的有效成分对成骨细胞的促进,破骨细胞的抑制,抑制骨矿的溶解和丢失,产生雄激素样作用等方面进行了阐述.把近年来中药对骨质疏松症治疗的作用和机制多方位的实验研究结果做了简要的综述.%Osteoporosis is a systemic metabolic disease caused by single or multiple factors. The features of osteoporosis are the decrease of bone mass, the degradation of microscopic structure of the bone tissue, and the decline in the mechanical properties of the bone. In recent years, the research of the treatment of osteoporosis with traditional Chinese medicine has increased. And progress has been achieved. Some frequent used traditional Chinese medicine, including Gusuibu, Yinyanghuo, Buguzhi, Xuduan, Duzhong, Huangqi, Bajitian, Lurong, Dansen, and Fuzi, is introduced in this paper. The paper reviews the effect of the medicine from their unique advantages of traditional function and modern effective ingredient on promoting osteoblasts, inhibiting osteoclasts, inhibiting the dissolution and loss of bone mineral, and generating the androgen - like action. This paper summarizes the research progress of traditional Chinese medicine for the treatment of osteoporosis and the experiment results in multiple mechanisms in recent years.

  5. Studies on chemical protectors against radiation, 34; Survival effects of aqueous extracts of various Chinese traditional medicines on radiation injury

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Cheng-Ming; Ohta, Setsuko; Shinoda, Masato (Hoshi Univ., Tokyo (Japan))

    1991-06-01

    In order to develop a nontoxic radioprotector, 60 kinds of Chinese traditional medicines were chosen, and their aqueous extracts tested for their survival effects against the lethal effect of X-irradiation in mice. Radiation factors used were as follows: soft X-rays, 2100 R (5.418x10{sup -1}Ckg{sup -1}), 70 kVp, 10 mA, 10 mm acrylic filter, 70 R (1.806x10{sup -2} Ckg{sup -1})/min. Among 60 medicines tested by intraperitoneal injection immediately before the irradiation, 15 are shown to have the significant survival effect. These 15 effective medicines were also tested by intraperitoneal injection after the irradiation, and the survival effect was recognized in Keisi-syakuyaku-chimo-to, Keigai-rengyo-to, Shimotu-to, Syakuyaku-kanzo-to and Hange-syasin-to. On the other hand, the survival effects of 25 medicines including the above-mentioned 15 medicines were investigated by the oral administration at various times before or after the irradiation. As the results of these studies, only Keigai-rengyo-to and Bukuryo-in are shown to have the significant survival effect when administered 2 h before the irradiation. (author).

  6. Barriers to Research Utilization among Registered Nurses in Traditional Chinese Medicine Hospitals: A Cross-Sectional Survey in China

    Directory of Open Access Journals (Sweden)

    Fen Zhou

    2015-01-01

    Full Text Available Background. As there might be relevant differences with regard to research utilization in the general hospitals, we aimed to study research utilization among registered nurses working in traditional Chinese medicine hospitals. Methods. A total of 648 registered nurses from 4 tertiary-level hospitals in China were recruited for participation. A modified BARRIERS Scale and self-designed questionnaires were used for data collection. Data were analyzed with descriptive statistics, t-tests, and one-way ANOVAs and Spearman correlation analysis. Results. Overall, items which belong to the subscale “Research” were identified as the most important barriers. Among the individual items, the lack of time on the job was ranked as the top barrier, followed by the lack of knowledgeable colleagues and by overwhelming research publications. Clinical experience, working pressure, job satisfaction, and research experience could be identified as associated factors for barriers to research utilization. Conclusions. Registered nurses in traditional Chinese medicine hospitals felt high barriers to research utilization. Reducing registered nurses’ working pressure, promoting their positive attitude to nursing, and improving research training might be helpful for increasing research utilization. Close cooperation between clinical and nursing schools or academic research centres might facilitate the necessary change in nursing education and routine.

  7. A Study on the Traditional Chinese Medicine Jinyebaidu for Prevention and Treatment of Intrauterine Infection with Guinea Pigs Cytomegalovirus

    Institute of Scientific and Technical Information of China (English)

    CHEN Suhua; XIONG Jinwen; XING Wei; WEN Liangzhen; LIU Haizhi; WANG Xinrong

    2005-01-01

    The purpose is to study the prophylactic and therapeutic effect of the traditional Chinese Medicine (TCM)-Jinyebaidu (JYBD) to guinea pig cytomegalovirus (GPCMV) intrauterine infec tion. The virus-free female and male guinea pigs were screened with nest-polymerase chain reaction (N-PCR). After inbred, pregnant guinea pigs were selected and divided into 3 groups randomly: 5guniea pigs of the blank control group were not given either GPCMV or JYBD. 31 guniea pigs of the positive control group were inoculated 1 mL (107 TCID50 ) suspension of GPCMV intraperitoneal. 10 guniea pigs of the experimental group were inoculated GPCMV firstly and then perfused stomach with JYBD for 14 days (Dosage in accordance with the modulus of the weight ratio of human to guniea pig). The effects of JYBD on the intrauterine infection of GPCMV were observed.The results showed that JYBD could decrease the maternal infection rate from 100 % (31/31) to 50% (5/10) (P<0. 001), the intrauterine infection rate from 100 % (72/72) to 75 % (21/28) (P<0. 001), and the rate of abnormal outcome of pregnancy from 64.4 % (29/45) to 25.0 % (7/28)(P<0. 001), the infective symptoms being relieved. It can be concluded that traditional Chinese medicine JYBD can prevent and treat GPCMV intrauterine infection, and can be expected a prophy lactic drug for HCMV intrauterine infection.

  8. Treatment for intractable anemia with the traditional Chinese medicines Hominis Placenta and Cervi Cornus Colla (deer antler glue

    Directory of Open Access Journals (Sweden)

    Yasuyo Hijikata

    2009-05-01

    Full Text Available Yasuyo Hijikata1, Takashi Kano2, Lu Xi31Toyodo Hijikata Clinic, Osaka, Japan; 2Kano Clinic, Osaka city, Osaka, Japan; 3Traditional Chinese Medicine Institute, Si-chuan Province, ChinaObjective: Intractable anemia, such as aplastic anemia or that presumably associated with chronic herpes virus infections, sometimes require bone marrow transplant. We investigated the use of traditional Chinese medicine (TCM for the treatment of intractable anemia. Method: Placenta Hominis (PH, steam boiled and roasted, and Cervi Cornus Colla (deer antler glue has been used in China for hundreds of years to treat anemia. After consent was obtained, we prescribed these two materials for a 74-year-old female with aplastic anemia and a 26-year-old male with presumably a virus-induced anemia. Concomitant conventional therapy was continued in both patients as prescribed by their respective attending physicians. Conclusion: Conventional therapy with steroid hormones, immunosuppressive drugs, platelet and erythrocyte transfusions were not effective in these patients. In addition, both patients suffered from serious side effects. In two patients, ingestion of Placenta Hominis and Cervi Cornus Colla with TCM prescriptions increased the platelet and enhanced the hemoglobin concentration in several months of therapy accompanied by a dramatic improvement in quality of life. The addition to conventional therapy of PH and Cervi Cornus Colla, the latter of which is very easy to obtain, may be one of the potentially advantageous choices in case of otherwise intractable anemia.Keywords: placenta, antler glue, Cervi Cornus Colla, anemia, aplastic anemia

  9. Anti-quorum sensing and antimicrobial activities of some traditional Chinese medicinal plants commonly used in South-East Asia

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    Yeo, S.S.M

    2012-01-01

    Full Text Available Aims: Traditional Chinese medicine (TCM has been used for relief and treatment of ailments dating back thousands of years and continues to the present day, with rapidly increasing interest in evidence-based evaluation of its efficacy. Studies of TCM plants have demonstrated that several have antimicrobial properties but few have explored their anti-quorum sensing potential. Quorum sensing (QS, also known as bacterial cell-to-cell communication, is used by a number of opportunistic pathogenic bacteria in the regulation of virulence expression. Compounds that interfere with QS signals and attenuate bacterial virulence without killing them may offer an alternative therapeutic solution with less pressure of antibiotic resistance developing. This study screened TCM plants for anti-quorum sensing properties and antimicrobial activities.Methodology and Results: Twenty TCM plants commonly used in South-East Asia were screened for QS inhibitors using two biomonitor strains, Chromobacterium violaceum CV026 and Pseudomonas aeruginosa PAO1. Ten of these selected TCM plant (50% were found to have QS inhibitory properties: Angelica sinensis (Umbelliferae, Cnidium monnieri (Umbelliferae, Astragalus membranaceus (Leguminosae, Crataegus cuneata (Rosaceae, Dioscorea nipponica (Dioscoreaceae, Lilium brownii (Liliaceae, Aloe barbadensis (Liliaceae, Magnolia officinalis (Magnoliaceae, Ephedra sinica (Ephedraceae and Panax pseudoginseng (Araliaceae. Of these, six (30% also showed varying antimicrobial activity against C. violaceum and P. aeruginosa.Conclusion, significance and impact of study: The results suggest that traditional Chinese medicinal plants could be a prospective source to explore for useful compounds in the fight against bacterial infections.

  10. Ultrasonic Nebulization Extraction Coupled with Gas Chromatography-Mass Spectrometry for Analysis of Volatile Components in Traditional Chinese Patent Medicine

    Institute of Scientific and Technical Information of China (English)

    LIANG Yue; WANG Lu; WANG Zi-ming; YU Cui; ZHANG Han-qi; SHI Yu-hua

    2011-01-01

    The ultrasonic nebulization extraction(UNE) was developed and applied to the extraction of volatile components from traditional Chinese patent medicine Xiaoyao Pills. Several parameters of ultrasonic nebulization extraction including the sample particle size, solvent volume, extraction time and ultrasonic power were studied and selected. As a result, 2.4 g of sample with particle size of 80 mesh was extracted with 15 mL of n-hexane for 20 min at an ultrasonic power of 35 W. The volatile components were analyzed by gas chromatography-mass spectrometry (GC-MS) under the optimal conditions and 57 compounds were identified. The precision, repeatability and stability of the proposed method were also studied. Compared with ultrasonic-assisted extraction(UAE) and hydrodistillation(HD) extraction, the proposed method is more efficient, faster and easier to be operated at room temperature with smaller sample and energy consumption. It is suggested that the ultrasonic nebulization extraction can be used as a novel alternative method for the extraction of volatile components from traditional Chinese patent medicine.

  11. Evaluation of Hypoglycemic Efficacy of Tangningtongluo Formula, a Traditional Chinese Miao Medicine, in Two Rodent Animal Models

    Directory of Open Access Journals (Sweden)

    Long Cheng

    2014-01-01

    Full Text Available Traditional Chinese medicines largely lack adequate and scientifically rigorous evidence regarding efficacy and functional mechanisms. The present study was aimed to confirm the hypoglycemic effect of Tangningtongluo (TNTL formula, a traditional Chinese Miao medicine, in two animal models: high-fat diet and streptozotocin- (STZ- induced diabetic rats and C57BL/KsJ-db/db diabetic mice. After 4 weeks, TNTL intervention in STZ-induced diabetic rats yielded in significant improvement on the glucose tolerance test. Moreover, the islet histopathology showed that oral TNTL reduced the severity of islet necrosis in pancreases tissue. Compared with diabetic controls, a 12-week TNTL treatment regimen (dosages = 0.9, 1.8, and 3.6 g/kg in db/db mice significantly decreased fasting glucose and HbA1c. Additionally, oral glucose tolerance in TNTL-treated mice improved significantly, compared with diabetic mice receiving metformin. Finally, tissue histopathology and biochemical index evaluations revealed significant improvement in TNTL-treated mice. Taken together, our results show that TNTL exerted a strong hypoglycemic effect in two diabetic rodent animal models, preserving β-cells in the pancreas islet and reducing the risk of diabetic retinopathy and nephropathy.

  12. Effect of Traditional Chinese Medicine Antiviral Capsules On Animal Model Genital Herpes and HSV-2 in Cell Culture

    Institute of Scientific and Technical Information of China (English)

    范瑞强; 李红毅; 谢长才; 禤国维; 朱宇同

    2001-01-01

    Objective: To study the effect of traditional Chinese medicine antiviral capsules in the treatment of genital herpes.Methods: Using female guinea pig genital herpes as the animal model, this study used oral administration of two formulations of antiviral capsules (AC) and observed the effect on vaginal HSV-2 titers and vulvar symptoms. Cell cultures were also used to examine the direct inactivation of HSV-2 by the antiviral capsules and the suppression of HSV-2 via three drug administration methods.Results: There was no significant difference of mean vaginal virus titers between the antiviral capsule groups and that of the positive acyclovir (ACV) control (P>0.05). Mean vulvar symptom scores of the two antiviral capsule groups were also significantly lower than that of the saline negative control group on days 2, 3, 5, 7 and 8 (P<0.05) and similar to that of the ACV control (P>0.05). Cell culture showed the minimum inhibitory concentrations of antiviral capsules No. 1 and No. 2 were 0.390625 mg/ml and 1,5625 mg/ml, respectively.Conclusion: The traditional Chinese medicine antiviral capsules had suppressive effects on HSV-2 in both animal model GH and in vitro cell culture.

  13. [Establishment of Caco-2 cell monolayer model with collagen coating 6-well plates for study of traditional Chinese medicine prescription].

    Science.gov (United States)

    Yang, Yan-Fang; Wu, Ni; Yang, Xiu-Wei

    2014-02-01

    Caco-2 cell monolayer model is widely utilized in drug absorption study and 12-well transwellTM plates were commonly used to study the absorption of different kinds of natural products. To establish a stable method for the study of traditional Chinese medicine prescription, 6-well plates were chosen because of the larger well volumes than 12-well plates. To study the impacts of collagen kinds, coating density as well as coating time on the cell culture, the transepithelial electrical resistance of Caco-2 cell monolayers grown on different collagen coating transwells was determined, and the permeations of propranolol and atenolol as standard markers were detected with HPLC. The results showed that the kinds of collagen, the different coating densities and coating time of rat tail collagen had no significant influences on the Caco-2 cell monolayer integrality and absorption capacity. 6-well plates coated with 2 micro g Scm-2 rat tail collagen for 1 hour were enough reliable and suitable for the study of traditional Chinese medicine prescription in vitro.

  14. [Rapid detection of four antipertensive chemicals adulterated in traditional Chinese medicine for hypertension using TLC-SERS].

    Science.gov (United States)

    Zhu, Qing-Xia; Cao, Yong-Bing; Cao, Ying-Ying; Lu, Feng

    2014-04-01

    A novel facile method for on-site detection of antipertensive chemicals (e. g. nicardipine hydrochloride, doxazosin mesylate, propranolol hydrochloride, and hydrochlorothiazide) adulterated in traditional Chinese medicine for hypertension using thin layer chromatography (TLC) combined with surface enhanced Raman spectroscopy (SERS) was reported in the present paper. Analytes and pharmaceutical matrices was separated by TLC, then SERS method was used to complete qualitative identification of trace substances on TLC plate. By optimizing colloidal silver concentration and developing solvent, as well as exploring the optimal limits of detection (LOD), the initially established TLC-SERS method was used to detect real hypertension Chinese pharmaceuticals. The results showed that this method had good specificity for the four chemicals and high sensitivity with a limit of detection as lower as to 0.005 microg. Finally, two of the ten antipertensive drugs were detected to be adulterated with chemicals. This simple and fast method can realize rapid detection of chemicals illegally for doping in antipertensive Chinese pharmaceuticals, and would have good prospects in on-site detection of chemicals for doping in Chinese pharmaceuticals.

  15. A Dialogue with the Ancient and Reflection on the Interpretation of History of Bianque and Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    Fu Youfeng

    2007-01-01

    Based on the description of epidemic diseases in the chapter of "The Story of Bianque" in Records of Historian, the author has analyzed and explored the truthfulness of its background data and the possibility of the plague spreading at that time from both macro and micro angles. The symptoms of plague including chills formation of some doctrines in Traditional Chinese Medicine (TCM) such as exopathic heat disease doctrine, internal injury of spleen and stomach doctrine and epidemic febrile disease doctrine. The course of exogenous phenomena, the author has explored the effect on the initial medical theory, primitive religion and culture due to the spreading of epidemic diseases from the angles of epidemiology, the theory of images and figures, originated from epidemic diseases was proposed. The author also put forward some opinions on the relationship between epidemic diseases spreading and traditional education of TCM, sustained development of TCM.

  16. A brief history of traditional Chinese medicinal pills%传统中药丸剂史述略

    Institute of Scientific and Technical Information of China (English)

    许霞; 陆翔; 朱建平

    2016-01-01

    传统中药丸剂,系指药材细粉或药材提取物加适宜黏合剂或其他辅料制成的球形或类球形剂型。中药丸剂是一种古老的传统剂型,它自先秦起源后,经汉代至明清,历代不断发展和丰富,适应疾病治疗的需要,制作工艺逐步完善,相继出现了蜜丸、蜡丸、包衣丸以及蜡壳丸等多种形式。近现代随着制药机械的进步,中药丸剂不断创新,现已成为批量生产的中成药的主要剂型。%Traditional Chinese medicine pill, an archaic medicinal preparation form,is a kind of spherical or spherical-like preparation form produced by medicinal powders or extracts mixed with appropri-ate excipient or other accessories. It was originated in the Pre-Qin Dynasty, developed and enriched from the Han Dynasty to the Ming and Qing Dynasties. With the improvement of preparing process, honeyed pill, waxed pill, coating pill and wax-coating pill etc. appeared in succession. In modern times, with the pro-gress of pharmaceutical machine, the medicinal pill is innovated constantly, and at present, it becomes the main form of Chinese patent medicine with batch production.

  17. Bioactive heterocyclic alkaloids with diterpene structure isolated from traditional Chinese medicines.

    Science.gov (United States)

    Xu, Tengfei; Liu, Shu; Meng, Lulu; Pi, Zifeng; Song, Fengrui; Liu, Zhiqiang

    2016-07-15

    The diterpenoid alkaloids as one type of heterocyclic alkaloids have been found in many traditional herbal medicines, such as genus Consolida, Aconitum, and Delphinium (Ranunculaceae). Pharmacological researches have indicated that many diterpenoid alkaloids are the main bioactive components which have analgesic, anti-inflammatory, anti-microbial, anti-tumor, cardiotonic, and anti-arrhythmic activities. Studies focused on the determination, quantitation and pharmacological properties of these alkaloids have dramatically increased during the past few years. Up to now, newly discovered diterpenoid alkaloids with important biological activities have been isolated and synthesized. Considering their significant role and diffusely used in many disease treatments, we summarized the information of their analysis methods, bioactivity, metabolism and biotransformation in vivo as well as the pharmacological mechanisms. Based on above review, the further researches are suggested.

  18. 中药洗发香波的研制%Preparation of Shampoo Containing Chinese Traditional Medicine

    Institute of Scientific and Technical Information of China (English)

    吕海珍

    2012-01-01

      Objective Preparation of Chinese traditional medicine shampoo. Methods With the boiling method of Chinese medicine Radix, Angelica, Astragalus extract the active ingredients, add to the already made selection a good shampoo formulations. Results The shampoo is brown transparent viscous liquid, good liquidity, aromatic scent. The heat-cold, skin contact, skin test, the shampoo and no adverse reaction. After preliminary trials with successful results.Conclusion The cost of this shampoo is close to shampoo available in the market, but the production process is simple, and as a result of natural shampoo containing Chinese medicine safety without side effects, have good development prospect.%  目的制取中药洗发香波。方法用煎煮法将中药何首乌、当归、黄芪有效成分提取后,加入到已筛选好的香波配方中,制成中药洗发香波。结果该香波为棕色透明液体,流动性好,气味芳香。经耐热耐寒、皮肤接触、人体皮肤实验均未见不良反应,经自愿者半年试用后效果良好。结论本产品的成本与市面上现有的同类产品接近,但本产品生产工艺简单,且由于中药洗发香波具有安全无副作用的特点,发展前景良好。

  19. Evaluating traditional Chinese medicine using modern clinical trial design and statistical methodology: application to a randomized controlled acupuncture trial.

    Science.gov (United States)

    Lao, Lixing; Huang, Yi; Feng, Chiguang; Berman, Brian M; Tan, Ming T

    2012-03-30

    Traditional Chinese medicine (TCM), used in China and other Asian counties for thousands of years, is increasingly utilized in Western countries. However, due to inherent differences in how Western medicine and this ancient modality are practiced, employing the so-called Western medicine-based gold standard research methods to evaluate TCM is challenging. This paper is a discussion of the obstacles inherent in the design and statistical analysis of clinical trials of TCM. It is based on our experience in designing and conducting a randomized controlled clinical trial of acupuncture for post-operative dental pain control in which acupuncture was shown to be statistically and significantly better than placebo in lengthening the median survival time to rescue drug. We demonstrate here that PH assumptions in the common Cox model did not hold in that trial and that TCM trials warrant more thoughtful modeling and more sophisticated models of statistical analysis. TCM study design entails all the challenges encountered in trials of drugs, devices, and surgical procedures in the Western medicine. We present possible solutions to some but leave many issues unresolved.

  20. Effect of powdered activated carbon on Chinese traditional medicine wastewater treatment in submerged membrane bioreactor with electronic control backwashing

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Chinese traditional medicine wastewater,rich in macromolecule and easy to foam in aerobic biodegradation such as Glycosides.was treated by two identical bench-scale aerobic submerged membrane bioreactors (SMBRs) operated in parallel under the same feed,equipped with the same electronic control backwashing device.One was used as the control SMBR (CSMBR) while the other was dosed with powdered activated carbon (PAC)(PAC-amended SMBR,PSMBR).The backwashing interval was 5 min.One suction period was about 90 min by adjusting preestablished backwashing vacuum and pump frequency.The average flux of CSMBR during a steady periodic state of 24 d (576 h) was 5.87 L/h with average hydraulic residence time (HRT) of 5.97h and that of PSMBR during a steady periodic state of 30 d (720 h) was 5.85 L/h with average HRT of 5.99 h.The average total chemical oxygen demand (COD) removal wastewater effluent standard GB8978-1996 for the raw medicine material industry (300 mg/L).Hence,SMBR with electronic control backwashing was a viable process for medium- strength Chinese traditional medicine wastewater treatment.Moreover,the increasing rates of preestablished backwashing vacuum,pump frequency,and vacuum and flux loss caused by mixed liquor in PSMBR all lagged compared to those in CSMBR:thus the actual operating time of the PSMBR system without membrane cleaning was extended by up to 1.25 times in contrast with the CSMBR system,and the average total COD removal efficieney of PSMBR was enhanced with higher average OLR.

  1. Traditional Chinese Biotechnology

    Science.gov (United States)

    Xu, Yan; Wang, Dong; Fan, Wen Lai; Mu, Xiao Qing; Chen, Jian

    The earliest industrial biotechnology originated in ancient China and developed into a vibrant industry in traditional Chinese liquor, rice wine, soy sauce, and vinegar. It is now a significant component of the Chinese economy valued annually at about 150 billion RMB. Although the production methods had existed and remained basically unchanged for centuries, modern developments in biotechnology and related fields in the last decades have greatly impacted on these industries and led to numerous technological innovations. In this chapter, the main biochemical processes and related technological innovations in traditional Chinese biotechnology are illustrated with recent advances in functional microbiology, microbial ecology, solid-state fermentation, enzymology, chemistry of impact flavor compounds, and improvements made to relevant traditional industrial facilities. Recent biotechnological advances in making Chinese liquor, rice wine, soy sauce, and vinegar are reviewed.

  2. Discussion of Modern Science Conception Changes and Traditional Chinese Medicine Development%论近现代科学观的变迁与中医发展

    Institute of Scientific and Technical Information of China (English)

    王慧; 吴鸿洲; 叶兴华

    2011-01-01

    The view of science in the 20th century is reviewed. The impact of changes of science view in the 20th century on traditional Chinese medicine is clarified. The impact of positivist view of science on traditional Chinese medicine continued from the early 20th century to the present. Within a certain range, positivist view of science has its positive significance. The impact of science view of historicism on traditional Chinese medicine reflects in the application of system science on traditional Chinese medicine. Science view of historicism features of tolerance of different cultures which makes traditional Chinese medicine develop on the base of Chinese culture, different from unilateral emphasis on science in the past. The study on traditional Chinese medicine which is characterized by developing on the base of basic theory of traditional Chinese medicine becomes more and more popular, being an important direction of study on modern study of traditional Chinese medicine.%回顾近现代中国科学观的变迁,阐明近现代科学观的变迁对中医发展的影响.实证主义科学观对中医发展的影响从20世纪初持续到现在,在一定范围内有其积极意义.历史主义科学观对现代中医的影响体现为以系统科学分析研究中医.历史主义科学观对不同文化间的包容使得中医的生存有了传统文化的土壤,而不是像以前一样单方面强调科学的影响.以坚持中医基本理论为发展基石的中医研究逐渐壮大,正成为当代中医研究的一个重要研究方向.

  3. Proven cases ensample of traditional Chinese medicine appropriate technology%中医适宜技术临证验案举隅

    Institute of Scientific and Technical Information of China (English)

    高永峰; 李怀民

    2015-01-01

    Traditional Chinese medicine appropriate technology refers to safe,effective,low cost,simple and easy to learn traditional Chinese medicine technology.This paper mainly on the analysis of 5 patients with diarrhea,lumbago,hyperhidrosis,red eyed disease and malnutritional stagnation.Using traditional Chinese medicine appropriate technology treatment has obvious curative effect.%中医适宜技术是指安全有效、成本低廉、简便易学的中医药技术。本文主要对腹泻、腰痛、多汗、红眼病及疳积这5例患者进行分析,运用中医适宜技术治疗疗效显著。

  4. 中药联合手法关节松动术治疗肩关节周围炎%The Effect of Traditional Chinese Arthrosis Mobilizrtion and Traditional Chinese Medicine In the Treatment of Shoulder Arthritis

    Institute of Scientific and Technical Information of China (English)

    王善甫

    2015-01-01

    目的:中药联合手法松动术治疗肩关节周围炎的临床观察.方法:采用中医手法关节松动术及中医辨证、中药内服、结合理疗措施治疗.结果:治疗患者痊愈率明显提高.结论:中医手法关节松动术及中医中药运用是治疗肩关节周围炎的一种理想方法.%Objective: To examine the therapeutic effect of traditional Chinese medicine(TCM)in treating shoulder arthritis based on the clinical observation results. Methods: The treatment method includes traditional Chinese arthritis mobilization, syndrome differentiation of TCM,oral administration of TCM, a combination of physical therapy. Results: The total efficiency of the patients with shoulder arthritis was significantly improved. Conclusion: Traditional Chinese arthrosis mobilization and traditional Chinese medicine is an effective method to treat shoulder arthritis.

  5. HPLC Method for Simultaneous Quantitative Detection of Quercetin and Curcuminoids in Traditional Chinese Medicines

    Directory of Open Access Journals (Sweden)

    Lee Fung Ang

    2014-12-01

    Full Text Available Objectives: Quercetin and curcuminoids are important bioactive compounds found in many herbs. Previously reported high performance liquid chromatography ultraviolet (HPLC-UV methods for the detection of quercetin and curcuminoids have several disadvantages, including unsatisfactory separation times and lack of validation according the standard guidelines of the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use. Methods: A rapid, specific, reversed phase, HPLC-UV method with an isocratic elution of acetonitrile and 2% v/v acetic acid (40% : 60% v/v (pH 2.6 at a flow rate of 1.3 mL/minutes, a column temperature of 35°C, and ultraviolet (UV detection at 370 nm was developed. The method was validated and applied to the quantification of different types of market available Chinese medicine extracts, pills and tablets. Results: The method allowed simultaneous determination of quercetin, bisdemethoxycurcumin, demethoxycurcumin and curcumin in the concentration ranges of 0.00488 ─ 200 μg/mL, 0.625 ─ 320 μg/mL, 0.07813 ─ 320 μg/mL and 0.03906 ─ 320 μg/mL, respectively. The limits of detection and quantification, respectively, were 0.00488 and 0.03906 μg/mL for quercetin, 0.62500 and 2.50000 μg/mL for bisdemethoxycurcumin, 0.07813 and 0.31250 μg/mL for demethoxycurcumin, and 0.03906 and 0.07813 μg/mL for curcumin. The percent relative intra day standard deviation (% RSD values were 0.432 ─ 0.806 μg/mL, 0.576 ─ 0.723 μg/ mL, 0.635 ─ 0.752 μg/mL and 0.655 ─ 0.732 μg/mL for quercetin, bisdemethoxycurcumin, demethoxycurcumin and curcumin, respectively, and those for intra day precision were 0.323 ─ 0.968 μg/mL, 0.805 ─ 0.854 μg/mL, 0.078 ─ 0.844 μg/mL and 0.275 ─ 0.829 μg/mL, respectively. The intra day accuracies were 99.589% ─ 100.821%, 98.588% ─ 101.084%, 9.289% ─ 100.88%, and 98.292% ─ 101.022% for quercetin, bisdemethoxycurcumin

  6. Anti-fungal and anti-bacterial activities of ethanol extracts of selected traditional Chinese medicinal herbs

    Institute of Scientific and Technical Information of China (English)

    Lin Zhang; ngeles Melguizo; Ester Jimnez; Francisca Vicente; Anjaneya S Ravipati; Sundar R Koyyalamudi; Sang Chul Jeong; Narsimha Reddy; John Bartlett; Paul T Smith; Mercedes de la Cruz; Maria Cndida Monteiro

    2013-01-01

    Objective:To evaluate in vitro antimicrobial activities of selected 58 ethno-medicinal plant extracts with a view to assess their therapeutic potential. Methods:A total of 58 traditional Chinese medicinal plants were carefully selected based on the literature review and their traditional use. The antimicrobial activities of ethanol extracts of these medicinal plants were tested against fungi (Aspergillus fumigatus), yeast (Candida albicans), gram-negative (Acinetobacter baumannii and Pseudomonas aeruginosa) and gram-positive bacteria (Staphylococcus aureus). The activities were tested at three different concentrations of 1.00, 0.10 and 0.01 mg/mL. The data was analysed using Gene data Screener program. Results: The measured antimicrobial activities indicated that out of the 58 plant extracts, 15 extracts showed anti-fungal activity and 23 extracts exhibited anti-bacterial activity. Eight plant extracts have exhibited both anti-bacterial and anti-fungal activities. For instance, Eucommia ulmoides, Polygonum cuspidatum, Poria cocos and Uncaria rhyncophylla showed activity against both bacterial and fungal strains, indicating their broad spectrum of activity. Conclusions: The results revealed that the ethanol extracts of 30 plants out of the selected 58 possess significant antimicrobial activities. It is interesting to note that the findings from the current study are consistent with the traditional use. A clear correlation has also been found between the antimicrobial activity and the flavonoid content of the plant extracts which is in agreement with the literature. Hence, the results presented here can be used to guide the selection of potential plant species for the isolation and structure elucidation of novel antimicrobial compounds in order to establish the structure-activity relationship. This in turn is expected to lead the way to the discovery of novel antimicrobial agents for therapeutic use.

  7. 中医药院校大学生中医体质与抑郁情绪的关系%The Relationship between Traditional Chinese Medicine University Students'Depression and Traditional Chinese Medicine(TCM)Constitution

    Institute of Scientific and Technical Information of China (English)

    邱男; 徐莹

    2016-01-01

    Objective:To explore the relationship between depression and Traditional Chinese Medicine(TCM)Con‐stitution in traditional Chinese medicine college students .Methods:Adopting the combination of convenience sampling and cluster sampling method ,Using the scale of Chinese Medicine ,Beck depression rating scale in 684 College students .Results:① 446 (65% )were without depression ,91 people (13% )with mild depression ,137 (20% )with moderate depression ,10 (1% )with severe depression and the mean score was very high(21 5.0 ± 2 6.4) .② Different gender(χ2 =12 0.49 ,P<0 0.1) ,different major(χ2 =5 9.10 ,P<0 0.5) ,whether or not only one child(χ2 =6 8.06 ,P<0 0.1) ,and different grades(χ2 =16 3.05 ,P<0 0.1)had significant difference in depression by nonparametric test of independent sample .③Traditional Chinese medicine gave priority to lopsided constitutions in cluding ,Yang deficiency quality(21% ) ,Qi deficiency quality(17 6.% ) ,Qi depression quality(16% ) .④Depression was negatively related to the situation with Gentleness ,Yang deficiency(Respectively :r=‐0 3.64 ,‐0 1.73 ,P<0 0.1);Positively correlated with oth‐er physical types .⑤ Through logistic regression analysis of risk factors ,depression would increase if the Traditional Chinese Medicine was Qi deficiency quality(OR=1 6.49 ,P<0 0.1) or Qi depression quality(OR=1 8.78 ,P<0 0.1) . Conclusion:The difference between the Traditional Chinese Medicine will affect the severity of the depression;Qi de‐ficiency ,Qi depression constitution are important factors of depression among college students .%目的:探讨中医药院校大学生中医体质与抑郁情绪之间的关系。方法:本研究以某中医药院校的在校本科生为研究对象,采用方便抽样与整群抽样相结合的方法,以684例大学生作为样本,以中医体质量表、贝克抑郁量表进行评定。结果:①446人(65%)无抑郁,91人(13%)轻度抑郁,137人(20

  8. Effects of ion source operating parameters on direct analysis in real time of 18 active components from traditional Chinese medicine.

    Science.gov (United States)

    Wang, Lu; Zeng, Shanshan; Qu, Haibin

    2016-03-20

    Direct analysis in real time mass spectrometry (DART-MS) provides a new analytical method for traditional Chinese medicine (TCM). The present study investigated the effects of key ion source operating parameters on DART-MS analysis of various TCM active components. A total of 18 active components, including phenylpropanoids, alkaloids, saponins, flavones, volatile oils, and glycosides, were examined. For each substance, the peak area and signal-to-noise of its characteristic ions under different reagent gases and heater temperatures were compared. Based on the comparison, the relationships among chemical structures, ion source parameters and instrument responses were revealed. Finally, some suggestions about choosing reagent gas and heater temperature were proposed for types of TCM active substance, which offered a reference for the application of DART-MS on TCM analysis.

  9. Screening of new non-nucleoside reverse transcriptase inhibitors of HIV-1 based on traditional Chinese medicines database

    Institute of Scientific and Technical Information of China (English)

    Tao Liu; Ai Xiu Li; You Pan Miao; Ke Zhu Wu; Yi Ma

    2009-01-01

    HIV-1 RT is an important target for the treatment of AIDS. There are two major classes of antiviral agents that inhibit HIV-1 RT have been identified, nucleoside RT inhibitors (NRTIs) and non-nucleoside RT inhibitors (NNRTIs). In this report, a noval class of non-nucleoside compound with potential RT inhibitory activity were found from the traditional Chinese medicines database (TCMD) using a combination of virtual screening, docking, molecular dynamic simulations, where results were ranked by scoring function of the docking tool. The result indicates that M4753 (a compound derived from TCMD) has not only the lowest bonding energy but also the best match in geometric conformation with the forthcoming NNRTIs. Accordingly M4753 might possibly become a promising lead compound of NNRTIs for AIDS therapy.

  10. [Post-marketing clinical study of traditional Chinese medicine--lessons learned from comprehensive evaluation of Fufang Zaoren capsule].

    Science.gov (United States)

    Qing, Shan; Gao, Lin; Zhang, Li; Jia, Jian-Ping; Liu, Xin-Min; Ji, Shao-Liang; Yang, Xiao-Hui

    2013-11-01

    By comprehensive review and analysis of post-marketing clinical research on the efficacy and safety,we concluded that Fufang Zaoren capsule has certain therapeutic effects for insomnia, although current clinical research design needs improving. The post-marketing clinical studies also showed that it causes several adverse reactions at the recommended doses, such as chills, fever, dizziness, nausea, shortness of breath, chest tightness and palpitations, whereas high doses of Fufang Zaoren capsule can cause delayed extrapyramidal symptoms. Health Canada government website also prompted the L-tetrahydropalmatine in Fufang Zaoren capsule caused liver damage in pregnant women. The authors summarized the risk points, factors and risk control in the clinical use of Fufang Zaoren capsule and also present their perspective on the research status, existing problems and corresponding countermeasures in the post-marketing clinical re-evaluation of traditional Chinese medicine.

  11. In vitro drug release and percutaneous behavior of poloxamer-based hydrogel formulation containing traditional Chinese medicine.

    Science.gov (United States)

    Wang, Wenyi; Hui, Patrick C L; Wat, Elaine; Ng, Frency S F; Kan, Chi-Wai; Wang, Xiaowen; Wong, Eric C W; Hu, Huawen; Chan, Ben; Lau, Clara B S; Leung, Ping-Chung

    2016-12-01

    For the treatment of atopic dermatitis (AD), we have developed a transdermal functionalized textile therapy based on thermosensitive poloxamer 407 (P407) hydrogel containing a traditional Chinese herbal medicine. This study aims to investigate the effects of various formulation variables of P407/carboxymethyl cellulose sodium (P407/CMCs) composite hydrogel on the release of Cortex Moutan (CM) extract. Concentrations of P407 and CMCs showed significant influence on the release due to alteration of bulk viscosity of the system. An increase in pH values of release medium was found to appreciably impede the release of polar drug (CM) due to ionization. Elevated temperatures were also shown to facilitate the drug release. Moreover, the diffusional release behavior of CM from P407/CMCs composite hydrogel was found to follow the first-order kinetic model. Additionally, transdermal studies showed that permeability of the drug through the skin can be enhanced with addition of CMCs in the hydrogel formulation.

  12. Nanocarriers for the delivery of active ingredients and fractions extracted from natural products used in traditional Chinese medicine (TCM).

    Science.gov (United States)

    Liu, Ying; Feng, Nianping

    2015-07-01

    Traditional Chinese medicine (TCM) has been practiced for thousands of years with a recent increase in popularity. Despite promising biological activities of active ingredients and fractions from TCM, their poor solubility, poor stability, short biological half-life, ease of metabolism and rapid elimination hinder their clinical application. Therefore, overcoming these problems to improve the therapeutic efficacy of TCM preparations is a major focus of pharmaceutical sciences. Recently, nanocarriers have drawn increasing attention for their excellent and efficient delivery of active TCM ingredients or fractions. This review discusses problems in the delivery of active TCM ingredients or fractions; focuses on recent advances in nanocarriers that represent potential solutions to these problems, including lipid-based nanoparticles and polymeric, inorganic, and hybrid nanocarriers; and discusses unanswered questions in the field and criteria for the development of better nanocarriers for the delivery of active TCM ingredients or fractions to be focused on in future studies.

  13. Traditional Chinese and Western Medicine Treatment of Hyperthyroidism Crisis%甲亢危象的中西医治疗

    Institute of Scientific and Technical Information of China (English)

    卢虹

    2013-01-01

    This paper summarizes the etiology,pathogenesis,diagnosis,treatment of traditional Chinese and Western medicine methods of hyperthyroidism crisis and hyperthyroidism crisis with neutropenia or agranulocytosis.A case of the portent with agranulocytosis was reported and analysed,so as to provide reference for the clinical treatment.%文章总结了甲亢危象及甲亢危象合并粒细胞减少或缺乏的病因、发病机制、诊断、中西医治疗方法.并报道分析了甲亢危象先兆合并粒细胞缺乏临床病案一例,为临床治疗提供借鉴.

  14. Integrating Traditional Chinese Medicine Services in Community Health Centers: Insights into Utilization Patterns in the Pearl River Region of China

    Directory of Open Access Journals (Sweden)

    Vincent C. H. Chung

    2013-01-01

    Full Text Available In China's healthcare reform, community health centers (CHCs are designed to take a pivotal role in providing primary care. Whilst about 20% of all outpatient care in China is delivered by the traditional Chinese medicine (TCM sector, hospitals, instead of CHCs, are major providers. Using current patterns of patient utilization this study aims to inform CHCs on how they may strengthen access to TCM services. Three thousand three hundred and sixty CHC patients from six cities within the urban Pearl Delta Region were enumerated using multistage cluster sampling. Fifty-two percent had visited herbalists within three months with a mean visit frequency of 1.50 times. Herbal treatments, which are cheaper than western medicines, were more popular amongst those who needed to pay out of pocket including the uninsured. Herbal medicines appeared to be an alternative for those who are underinsured. Acupuncturists and massage therapists were visited by smaller proportions, 6.58% and 5.98%, respectively, with a mean three-month visit of 0.27 and 0.26 times. Access was restricted by lack of social insurance coverage. Whilst increasing provision of TCM in CHCs might respond to patient demand, increasing insurance coverage for TCM needs to be evaluated using current evidence on safety and effectiveness.

  15. The Ethics of Traditional Chinese and Western Herbal Medicine Research: Views of Researchers and Human Ethics Committees in Australia

    Directory of Open Access Journals (Sweden)

    Caroline A. Smith

    2011-01-01

    Full Text Available Despite the growth of traditional Chinese medicine (TCM and western herbal medicine (WHM research in Australia, little is known about how ethics committees (HRECs assess the ethics of TCM or WHM research. The objectives of this study were to examine the experiences of TCM and WHM researchers and HRECs with the evaluation of ethics applications. Two cross-sectional surveys were undertaken of HRECs and TCM and WHM researchers in Australia. Anonymous self-completion questionnaires were administered to 224 HRECs and 117 researchers. A response confirming involvement in TCM or WHM research applications was received from 20 HRECs and 42 researchers. The most frequent ethical issues identified by HRECs related to herbal products including information gaps relating to mode of action of herbal medicines and safety when combining herbal ingredients. Researchers concurred that they were frequently requested to provide additional information on multiple aspects including safety relating to the side effects of herbs and herb-drug interactions. Overall adherence with the principles of ethical conduct was high among TCM and WHM researchers although our study did identify the need for additional information regarding assessment of risk and risk management.

  16. Extracts from Traditional Chinese Medicinal Plants Inhibit Acetylcholinesterase, a Known Alzheimer’s Disease Target

    Directory of Open Access Journals (Sweden)

    Dorothea Kaufmann

    2016-08-01

    Full Text Available Inhibition of acetylcholinesterase (AChE is a common treatment for early stages of the most general form of dementia, Alzheimer’s Disease (AD. In this study, methanol, dichloromethane and aqueous crude extracts from 80 Traditional Chinese Medical (TCM plants were tested for their in vitro anti-acetylcholinesterase activity based on Ellman’s colorimetric assay. All three extracts of Berberis bealei (formerly Mahonia bealei, Coptis chinensis and Phellodendron chinense, which contain numerous isoquinoline alkaloids, substantially inhibited AChE. The methanol and aqueous extracts of Coptis chinensis showed IC50 values of 0.031 µg/mL and 2.5 µg/mL, therefore having an up to 100-fold stronger AChE inhibitory activity than the already known AChE inhibitor galantamine (IC50 = 4.33 µg/mL. Combinations of individual alkaloids berberine, coptisine and palmatine resulted in a synergistic enhancement of ACh inhibition. Therefore, the mode of AChE inhibition of crude extracts of Coptis chinensis, Berberis bealei and Phellodendron chinense is probably due to of this synergism of isoquinoline alkaloids. All extracts were also tested for their cytotoxicity in COS7 cells and none of the most active extracts was cytotoxic at the concentrations which inhibit AChE. Based on these results it can be stated that some TCM plants inhibit AChE via synergistic interaction of their secondary metabolites. The possibility to isolate pure lead compounds from the crude extracts or to administer these as nutraceuticals or as cheap alternative to drugs in third world countries make TCM plants a versatile source of natural inhibitors of AChE.

  17. Traditional Chinese Medicine (TCM and Herbal Hepatotoxicity: RUCAM and the Role of Novel Diagnostic Biomarkers Such as MicroRNAs

    Directory of Open Access Journals (Sweden)

    Rolf Teschke

    2016-07-01

    Full Text Available Background: Traditional Chinese Medicine (TCM with its focus on herbal use is popular and appreciated worldwide with increased tendency, although its therapeutic efficacy is poorly established for most herbal TCM products. Treatment was perceived as fairly safe but discussions emerged more recently as to whether herb induced liver injury (HILI from herbal TCM is a major issue; Methods: To analyze clinical and case characteristics of HILI caused by herbal TCM, we undertook a selective literature search in the PubMed database with the search items Traditional Chinese Medicine, TCM, alone and combined with the terms herbal hepatotoxicity or herb induced liver injury; Results: HILI caused by herbal TCM is rare and similarly to drugs can be caused by an unpredictable idiosyncratic or a predictable intrinsic reaction. Clinical features of liver injury from herbal TCM products are variable, and specific diagnostic biomarkers such as microsomal epoxide hydrolase, pyrrole-protein adducts, metabolomics, and microRNAs are available for only a few TCM herbs. The diagnosis is ascertained if alternative causes are validly excluded and causality levels of probable or highly probable are achieved applying the liver specific RUCAM (Roussel Uclaf Causality Assessment Method as the most commonly used diagnostic tool worldwide. Case evaluation may be confounded by inappropriate or lacking causality assessment, poor herbal product quality, insufficiently documented cases, and failing to exclude alternative causes such as infections by hepatotropic viruses including hepatitis E virus infections; Conclusion: Suspected cases of liver injury from herbal TCM represent major challenges that deserve special clinical and regulatory attention to improve the quality of case evaluations and ascertain patients’ safety and benefit.

  18. 中医药学语言系统研究进展%Progress of Research on the Language System of Traditional Chinese Medicine/J

    Institute of Scientific and Technical Information of China (English)

    贾李蓉; 于彤; 崔蒙; 杨硕; 刘静; 朱玲; 董燕; 高博; 刘丽红

    2014-01-01

    The language system of traditional Chinese medicine is a large terminological system developed by Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, since 2002. The system integrates concepts and terms in the field of traditional Chinese medicine and its related subjects, builds the semantic relations among concepts, and provides the term support for the informatization of the subject of traditional Chinese medicine. This paper introduces the research progress of the system since its establishment.%中医药学语言系统是中国中医科学院中医药信息研究所于2002年开始研制的大型术语系统。系统集合了中医药及其相关学科的领域概念术语,构建了概念间的语义关系,为中医药学科的信息化提供了术语支持。着重介绍了系统从建立至今的研究进展。

  19. Study on the Exploitation and Utilization of Traditional Food Safety and Chinese Medicine Resources in Rural Areas-based on the Survey of Tongcheng Anhui

    Directory of Open Access Journals (Sweden)

    Zhen-Bo Xu

    2015-07-01

    Full Text Available In this study, we have a study on the exploitation and utilization of traditional food safety and Chinese medicine resources in rural areas based on the survey of Tongcheng Anhui. There are a large variety and effectiveness of Traditional Chinese Medicine (TCM resources in vast rural areas and they are the material basis for the development of TCM cause and research of TCM products. For a long time, however, because of various objective and subjective factors such as lacking of due attention to development and utilization of the resources of TCM, the cause of traditional Chinese medicine in rural areas are lack of development potential. By selecting a representative sample of rural Tongcheng in Anhui and on the basis of investigation on development and utilization of local traditional Chinese medicine resources, we should analyze current problems of development and utilization of existing rural medicine resource and propose suggestions from the aspects of government and farmers research. In this way, we can provide a reference to the motherland researchers and workers of the pharmaceutical industry.

  20. Exploration and Analysis of Sources Causing a Dilemma of Traditional Chinese Medicine in Modern Times%近代中医困境根源探析

    Institute of Scientific and Technical Information of China (English)

    盛海英

    2011-01-01

    As traditional Chinese medicine has been applied to medical practices in China for several thousands years, it has developed a mature theoretical system and its efficacy is confirmed by numerous historical facts. However, traditional Chinese medicine begins falling into a dilemma in Modern Times. The main causes for the dilemma include: The huge impact caused by the import of western medicine into Asian countries; The exemplary effect of extinguishing Kampo medicine in the Japanese medical community; Large amounts of introduction of Western science and technology, especially the influence of the ideology saving the nation by science and technology; The influence of debate over Chinese and Western culture on the conflict between Traditional Chinese Medicine and Western Medicine.%中医在中国应用了几千年,有着成熟的理论体系,其疗效已经被无数的历史事实所证实.但在近代,中医却开始陷入困境,其主要原因有:西医东渐的巨大冲击;日本废止汉方医的示范效应;西方科学技术的大举输入,特别是科学救国思潮的影响,中西文化论争对中西医学冲突的影响.

  1. Instruction to Authors of Chinese Herbal Medicines

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    @@ Chinese Herbal Medicines, an international journal sponsored by the Tianjin Institute of Pharmaceutical Research and Institute of Medicinal Plant Develop-ment. The Journal s purpose is to provide a forum for the studies on Chinese herbal medicines, traditional medicines, and natural products.

  2. [Inheritance on and innovation of traditional Chinese medicine (TCM) flavor theory and TCM flavor standardization principle flavor theory in Compendium of Materia Medica].

    Science.gov (United States)

    Zhang, Wei; Zhang, Rui-xian; Li, Jian

    2015-12-01

    All previous literatures about Chinese herbal medicines show distinctive traditional Chinese medicine (TCM) flavors. Compendium of Materia Medica is an influential book in TCM history. The TCM flavor theory and flavor standardization principle in this book has important significance for modern TCM flavor standardization. Compendium of Materia Medica pays attention to the flavor theory, explain the relations between the flavor of medicine and its therapeutic effects by means of Neo-Confucianism of the Song and Ming Dynasties. However,the book has not reflected and further developed the systemic theory, which originated in the Jin and Yuan dynasty. In Compendium of Materia Medica , flavor are standardized just by tasting medicines, instead of deducing flavors. Therefore, medicine tasting should be adopted as the major method to standardize the flavor of medicine.

  3. Research progress of traditional Chinese medicine of lung cancer patients with insomnia%肺癌患者失眠的中医研究进展

    Institute of Scientific and Technical Information of China (English)

    尹光宇; 赵连强

    2015-01-01

    Chinese medicine treatment of lung cancer insomnia and research literature related to the treatment of traditional Chinese medicine is relatively small, insomnia in patients with lung cancer efficacy evaluation of traditional Chinese medicine is also a lack of unified standards. Improve this aspect of the work, can provide support for future researchers and clinical workers.%中医药治疗肺癌失眠的研究文献以及相关中医治疗方案相对较少,对肺癌患者失眠的中医药疗效评价也缺乏统一标准.完善这方面的工作,可以为后续研究者和临床工作者提供支撑.

  4. Are national quality standards for traditional Chinese herbal medicine sufficient? Current governmental regulations for traditional Chinese herbal medicine in certain Western countries and China as the Eastern origin country.

    Science.gov (United States)

    Dobos, G J; Tan, L; Cohen, M H; McIntyre, M; Bauer, R; Li, X; Bensoussan, A

    2005-09-01

    Traditional Chinese herbal Medicine (TCHM) has been gaining interest and acceptance world wide. TCHM provides on the one side promising perspective of scientific interest and on the other side possible health risks if TCHM drugs are not controlled with respect to quality standards or if practitioners for TCHM are not well trained. This paper outlines an introduction to the scientific aspects and potential risks of TCHM therapy followed by a brief, exploratory overview of the current status of TCHM regulations in certain Western countries like the USA, United Kingdom, Germany, Australia and in China as the Eastern origin country of TCHM. Legal foundations to establish quality and safety standards for TCHM crude drugs and ready-made formulas exist in some countries on a local basis but in practice are poorly enforced, where this products have no drug status. In addition practitioners treating patients with TCHM should be well versed in the pharmacology, side effects, and interactions of these substances with Western medicines and should be certified on a regular basis.

  5. 中医疾病观视角下的叙事医学%Narrative medicine under the view of traditional Chinese medicine on dis-eases

    Institute of Scientific and Technical Information of China (English)

    巩亚男; 杜渐; 李志荣; 刘珍珠; 徐祥芸; 王昊; 杨秋莉

    2016-01-01

    中医疾病观是中医学认识疾病本质,研究疾病发生、发展规律的基本观点,它以时-空-生物-心理-社会医学模式的整体观为指导思想。叙事医学从时间、空间两个角度出发,肯定生物因素影响病情的同时,强调社会制度、家庭伦理、人文关怀、个体感受对于疾病发生、发展的影响,以社会建构的视角来看待人类的疾病历程。从中医疾病观的角度出发,进一步理解中西方叙事医学的关系,以加深对叙事医学的理解。%The view of traditional Chinese medicine (TCM)on diseases,which is guided by the holistic model of time-space-bio-phycho-social medicine,refers to the basic viewpoints of TCMon the nature,oc-currence and development of the diseases.Narrative medicine views the disease course with the social constructivism from the viewpoint of time and space,which not only affirms the diseases affected by bio-logical factors,but also emphasizes the occurrence and development of diseases influenced by social sys-tem,family ethics,humanistic concern and personal feeling.To further study the correlation between Chinese and Western narrative medicine from the view of TCM on diseases,so as to understand the narra-tive medicine.

  6. Recent Research of Traditional Chinese Medicine on Diabetic Nephropathy%中医药治疗糖尿病肾病研究近况

    Institute of Scientific and Technical Information of China (English)

    韩文可; 彭文

    2015-01-01

    Traditional Chinese medicine occupies an important positionin in the treatment of diabetic nephropathy (DN).The denominate of this disease,its etiology and pathogenesis,Synrome differentiation and classification,the Chinese prescription made by ourselvses,Chinese patent medicine,single Chinese medicine and their effective components and other therapy will be reviewed in this artical.%中医药在糖尿病肾病(DN)的治疗中占有重要的地位,本文从病名、病因病机、辨证分型、自拟方、中成药、单味中药及中药提取物和其他疗法进行综述。

  7. Tongrentang,A Pearl of Chinese Traditional Medicine Interview with Mei Qun, General Manager of China Beijing Tongrentang(Group) Co., Ltd.

    Institute of Scientific and Technical Information of China (English)

    Sun Yongjian; Bai Yifeng

    2006-01-01

    @@ On June 10, China Beijing Tongrentang (Group) Co., Ltd. celebrated its first Day of Cultural Heritage because its brand Tongrentang had been registered in the Directory of Chinese Intangible Cultural Heritages. Tongrentang is welknown in China for its effective Chinese traditional medicine, but what is the core value of the brand? Mei Qun, General Manager of China Beijing Tongrentang(Group) Co., Ltd. let the secret out when interviewed by China's Foreign Trade.

  8. Searching for synergistic bronchodilators and novel therapeutic regimens for chronic lung diseases from a traditional Chinese medicine, Qingfei Xiaoyan Wan.

    Directory of Open Access Journals (Sweden)

    Yuanyuan Hou

    Full Text Available Classical Chinese pharmacopeias describe numerous excellent herbal formulations, and each prescription is an outstanding pool of effective compounds for drug discovery. Clarifying the bioactivity of the combined mechanisms of the ingredients in complex traditional Chinese medicine formulas is challenging. A classical formula known as Qingfei Xiaoyan Wan, used clinically as a treatment for prevalent chronic lung disease, was investigated in this work. A mutually enhanced bioactivity-guided ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF-MS characterization system was proposed, coupled with a dual-luciferase reporter assay for β2AR-agonist cofactor screening. Arctiin, arctigenin, descurainoside and descurainolide B, four lignin compounds that showed synergistic bronchodilation effects with ephedrine, were revealed. The synergistic mechanism of arctigenin with the β2ARagonist involved with the reduction of free Ca2+ was clarified by a dual-luciferase reporter assay for intracellular calcium and the Ca2+ indicator fluo-4/AM to monitor changes in the fluorescence. The relaxant and contractile responses of airway smooth muscle are regulated by crosstalk between the intracellular cAMP and calcium signaling pathways. Our data indicated the non-selective βAR agonist ephedrine as the principal bronchodilator of the formula, whereas the lignin ingredients served as adjuvant ingredients. A greater understanding of the mechanisms governing the control of these pathways, based on conventional wisdom, could lead to the identification of novel therapeutic targets or new agents for the treatment of asthma and COPD.

  9. Systematic Evaluation on Clinical Efifcacy of External Application of Traditional Chinese Medicine in Treatment of Breast Hyperplasia

    Institute of Scientific and Technical Information of China (English)

    LYU Yan-hong; XIANG Jing-fang; ZHANG Kang; LU Qin

    2015-01-01

    Objective:To evaluate the clinical efifcacy of external application of traditional Chinese medicine (TCM) in the treatment of breast hyperplasia. Methods:Randomized controlled clinical trial literatures on external application of TCM in the treatment of breast hyperplasia in PubMed, Excerpta Medica Database (EMBASE), Cochrane Central Register of Controlled Trials (CENTRAL), China National Knowledge Infrastructure Database (CNKI) and Chinese Biomedical Abstract Database (CBM) from January 2000 to August 2015 were retrieved, and screened by researchers to data extraction. RevMan 5.3 was applied for meta analysis. Results: A total of 15 clinical trials with 2 107 patients with breast hyperplasia were included, in which 1 151 were divided into treatment group treated with external application of TCM while 956 into control group. Meta analysis indicated that the clinical response rate and improvement of symptom scores (breast lump size) as well as serum levels of estradiol (E2), progesterone (P) and prolactin (PRL) in treatment group were superior to the control group and the differences were statistically significant (P0.05). Conclusion: External application of TCM, to some extent, can improve the clinical efifcacy in the treatment of breast hyperplasia, and it is necessary to carry out higher-quality, multicenter, large-scale, prospective and double-blind clinical trials for further validation.

  10. Progression of Taboo Traditional Chinese Medicine in Gestational Period%妊娠期用药禁忌研究进展

    Institute of Scientific and Technical Information of China (English)

    吴楚良

    2012-01-01

    Objective:To comprehend the progression of taboo traditional Chinese medicine(TCM) in gestational period. Methods:Collect ancient classic records of Chinese medicine analyze modern authority records and literature about modcrn traditional Chinese medicine pregnancy toxicology research. Results:The taboo of Chinese medicine in gestational period has controversial and there is no unified standards. Conclusion:Taboo of Chinese medicine in gestational period needs further in-depth study.%目的:了解妊娠期用药禁忌的研究进展.方法:收集中医药古代经典书籍记载、中医药现代权威书籍记载及现代中药妊娠毒理学研究的相关文献报道等方面的资料进行归纳分析.结果:妊娠期禁忌中药的品种存在争议,尚无统一标准.结论:妊娠期中药禁忌有待进一步深入研究.

  11. Clinical Service of Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ The clinical practice of traditional Chinese medicine (TCM) faces three major challenges:(1)How to enhance its contribution on overall medical service quality? (2) How to best address the unmet medical needs in the contemporary society? (3)How to guarantee that the traditional perspective for disease diagnosis and treatment not be neglected in clinical practice?

  12. Alternative Treatment for Asthma: Case Study of Success of Traditional Chinese Medicine Treatment of Children from Urban Areas with Different Levels of Environmental Pollution

    Science.gov (United States)

    Kopnina, Helen

    2012-01-01

    The present study examined efficacy of traditional Chinese medicine (TCM) treatment in Dutch children with asthma in areas with differing air pollution. The study results indicate that TCM treatment of children living in more polluted urban area is less successful then that of children living in cleaner air area. PMID:23724242

  13. Phylogenetic Tree Analysis of the Cold-Hot Nature of Traditional Chinese Marine Medicine for Possible Anticancer Activity

    Directory of Open Access Journals (Sweden)

    Xianjun Fu

    2017-01-01

    Full Text Available Traditional Chinese Marine Medicine (TCMM represents one of the medicinal resources for research and development of novel anticancer drugs. In this study, to investigate the presence of anticancer activity (AA displayed by cold or hot nature of TCMM, we analyzed the association relationship and the distribution regularity of TCMMs with different nature (613 TCMMs originated from 1,091 species of marine organisms via association rules mining and phylogenetic tree analysis. The screened association rules were collected from three taxonomy groups: (1 Bacteria superkingdom, Phaeophyceae class, Fucales order, Sargassaceae family, and Sargassum genus; (2 Viridiplantae kingdom, Streptophyta phylum, Malpighiales class, and Rhizophoraceae family; (3 Holothuroidea class, Aspidochirotida order, and Holothuria genus. Our analyses showed that TCMMs with closer taxonomic relationship were more likely to possess anticancer bioactivity. We found that the cluster pattern of marine organisms with reported AA tended to cluster with cold nature TCMMs. Moreover, TCMMs with salty-cold nature demonstrated properties for softening hard mass and removing stasis to treat cancers, and species within Metazoa or Viridiplantae kingdom of cold nature were more likely to contain AA properties. We propose that TCMMs from these marine groups may enable focused bioprospecting for discovery of novel anticancer drugs derived from marine bioresources.

  14. [Impact on evaluation of clinical efficacy of traditional Chinese medicine for level in soft targets of processing technology].

    Science.gov (United States)

    Shao, Ming-Yi; Wei, Ming; Yan, Bo-Hua

    2014-04-01

    Traditional Chinese medicine (TCM) is a very practical subject, which has its unique theoretical system and clinical characteristics. In the course of clinical practice, the exact clinical efficacy is the key of existence and development. But the existing evaluation system is difficult to objectively evaluate the clinical efficacy of TCM. Therefore, how to objectively evaluate the clinical efficacy and get definitive evidence is the focus of the evaluation of clinical efficacy of TCM. Relative to modern medicine, TCM is more concerned about the changes of feelings and clinical symptoms of the patient in the course of the evolution of the disease. Soft targets mainly used for the evaluation of the clinical efficacy of symptoms and functional activity of the disease. The level in soft targets of processing technology is often used methods in clinical evaluation. But it has often produced the phenomenon which the results of the evaluation is mutual contradiction, which will ultimately affect the effect of evaluation of clinical efficacy of TCM. In order to better evaluate the clinical efficacy of TCM, in the process of adoption of soft targets, it clearly identify it's role, highlighting the characteristics of interventions on disease, and as much as possibly avoid the level in soft targets of processing technology to real assess clinical efficacy of TCM.

  15. Discrimination and Analysis of the Toxicity of Traditional Chinese Medicine%中药毒性辨析论

    Institute of Scientific and Technical Information of China (English)

    卢芳; 刘树民

    2011-01-01

    在以往毒性研究的基础上,通过整理大量文献,明晰了中药毒性的内涵,透析了中药毒性的特点及研究难点,评析了中药毒性的发生缘由,剖析了中药毒性的研究现状,解析了中药与西药的本质差异,并探析了中药毒性的研究思路.通过对中药毒性诸多问题的阐述,使国内外人员能正确评价和认识中药毒性,亦可为中医药科研工作者提供研究方向.%In this paper we sorted out a large number of literatures based on our studies about the toxicity in the past, clarifying the connotation of the toxicity of traditional chinese medicine( TCM ), analyzing its characteristics and research nodus, commenting the incidence of the toxicity of TCM, remarking its current research situation, explaining the essential difference between TCM and western medicine, and exploring its research route. By expounding many problems on the toxicity of TCM, domestic and foreign personnel can properly evaluate and understand toxicity of TCM, and it can provide research directions for scientific research workers of TCM.

  16. Flavonoids, derived from traditional Chinese medicines, show roles in the differentiation of neurons: possible targets in developing health food products.

    Science.gov (United States)

    Xu, Sherry L; Zhu, Kevin Y; Bi, Cathy W C; Yan, Lu; Men, Simon W X; Dong, Tina T X; Tsim, Karl W K

    2013-12-01

    Flavonoids, a family of phenolic compounds, are distributed in a variety of fruits, vegetables, tea, and wine. More importantly, many flavonoids are served as the active ingredients in traditional Chinese herbal medicines, which in general do not have side effects. Several lines of evidence support that flavonoids have impacts on many aspects of human health, including anti-tumor, anti-oxidation, and anti-inflammation. Recently, there is significant attention focused on the neuronal beneficial effects of flavonoids, including the promotion of nervous system development, neuroprotection against neurotoxin stress, as well as the promotion of memory, learning, and cognitive functions. Here, the activities of flavonoids on the development of nervous system are being summarized and discussed. The flavonoids from diverse herbal medicines have significant effects in different developmental stages of nervous systems, including neuronal stem cell differentiation, neurite outgrowth, and neuronal plasticity. These findings imply that flavonoids are potential candidates for the development of health supplements in preventing birth defects and neuronal diseases.

  17. New possibility of traditional Chinese and Japanese medicine as treatment for behavioral and psychiatric symptoms in dementia

    Directory of Open Access Journals (Sweden)

    Kung FC

    2012-10-01

    Full Text Available Fan-Chin Kung,1 Ryouhei Ishii,2 Hsing-Cheng Liu,3 Masatoshi Takeda21Yuli Hospital, DOH, Hualien, Taiwan; 2Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan; 3Department of General Psychiatry, Taipei City Psychiatric Center, Taipei, TaiwanAbstract: Yokukansan, one of the Kampo prescriptions, is composed of seven herbaceous plants and was developed in China in the 16th century as a cure for restlessness and agitation in children. Yokukansan has also become a popular drug combination in Japan, especially for the behavioral and psychiatric symptoms of dementia (BPSD. Recent studies have shown that yokukansan might also be quite effective against BPSD occurring in association with other types of dementia, such as Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, frontotemporal dementia, and vascular dementia. Researchers have intensively investigated yokukansan, focusing on the pharmacological mechanisms against glutamate-mediated excitotoxicity. This traditional Chinese and Japanese medicine holds potential promise for improving BPSD in elderly patients suffering from dementia.Keywords: yokukansan, dementia, Alzheimer's disease, behavioral and psychological symptoms of dementia, Kampo, glutamate

  18. Combined DNA, toxicological and heavy metal analyses provides an auditing toolkit to improve pharmacovigilance of traditional Chinese medicine (TCM)

    Science.gov (United States)

    Coghlan, Megan L.; Maker, Garth; Crighton, Elly; Haile, James; Murray, Dáithí C.; White, Nicole E.; Byard, Roger W.; Bellgard, Matthew I.; Mullaney, Ian; Trengove, Robert; Allcock, Richard J. N.; Nash, Christine; Hoban, Claire; Jarrett, Kevin; Edwards, Ross; Musgrave, Ian F.; Bunce, Michael

    2015-12-01

    Globally, there has been an increase in the use of herbal remedies including traditional Chinese medicine (TCM). There is a perception that products are natural, safe and effectively regulated, however, regulatory agencies are hampered by a lack of a toolkit to audit ingredient lists, adulterants and constituent active compounds. Here, for the first time, a multidisciplinary approach to assessing the molecular content of 26 TCMs is described. Next generation DNA sequencing is combined with toxicological and heavy metal screening by separation techniques and mass spectrometry (MS) to provide a comprehensive audit. Genetic analysis revealed that 50% of samples contained DNA of undeclared plant or animal taxa, including an endangered species of Panthera (snow leopard). In 50% of the TCMs, an undeclared pharmaceutical agent was detected including warfarin, dexamethasone, diclofenac, cyproheptadine and paracetamol. Mass spectrometry revealed heavy metals including arsenic, lead and cadmium, one with a level of arsenic >10 times the acceptable limit. The study showed 92% of the TCMs examined were found to have some form of contamination and/or substitution. This study demonstrates that a combination of molecular methodologies can provide an effective means by which to audit complementary and alternative medicines.

  19. Phylogenetic Tree Analysis of the Cold-Hot Nature of Traditional Chinese Marine Medicine for Possible Anticancer Activity

    Science.gov (United States)

    Song, Xuxia; Li, Xuebo; Zhang, Fengcong; Wang, Changyun

    2017-01-01

    Traditional Chinese Marine Medicine (TCMM) represents one of the medicinal resources for research and development of novel anticancer drugs. In this study, to investigate the presence of anticancer activity (AA) displayed by cold or hot nature of TCMM, we analyzed the association relationship and the distribution regularity of TCMMs with different nature (613 TCMMs originated from 1,091 species of marine organisms) via association rules mining and phylogenetic tree analysis. The screened association rules were collected from three taxonomy groups: (1) Bacteria superkingdom, Phaeophyceae class, Fucales order, Sargassaceae family, and Sargassum genus; (2) Viridiplantae kingdom, Streptophyta phylum, Malpighiales class, and Rhizophoraceae family; (3) Holothuroidea class, Aspidochirotida order, and Holothuria genus. Our analyses showed that TCMMs with closer taxonomic relationship were more likely to possess anticancer bioactivity. We found that the cluster pattern of marine organisms with reported AA tended to cluster with cold nature TCMMs. Moreover, TCMMs with salty-cold nature demonstrated properties for softening hard mass and removing stasis to treat cancers, and species within Metazoa or Viridiplantae kingdom of cold nature were more likely to contain AA properties. We propose that TCMMs from these marine groups may enable focused bioprospecting for discovery of novel anticancer drugs derived from marine bioresources. PMID:28191021

  20. tudy on Diagnosis and Treatment of Infectious Multiple Organ Dysfunction Syndrome by Integrated Traditional Chinese and Western Medicine

    Institute of Scientific and Technical Information of China (English)

    张淑文; 任爱民; 张丽霞; 王红; 毕铭华; 李昂; 次秀丽; 王彦; 齐文杰; 王宝恩

    2001-01-01

    Objective: To explore the diagnostic and therapeutic approach of integrated traditional Chinese and western medicine (TCM-WM) on infectious multiple organs dysfunction syndrome/multiple system and organ failure (MODS/MSOF) for elevating the successful rate of rescuing the patients. Methods: Diagnosis with western medicine and Syndrome Differentiation of TCM in 225 in-patients of acute infectious disease complicated with MODS/MSOF were conducted, and TCM treatment, based on western medical comprehensive treatment, was given to observe the effect and explore the mechanism of the TCM-WM therapy. Results: Up to the end of 1998, 161 cases of the 225 cases were successfully cured and 64 died, the mortality being 28.4%. Among them, 58 out of 140 cases of MSOF died, the mortality was accounted for 41.4%. In 106 cases conformed to the diagnostic criteria of MSOF proposed by Professor Knaus WA, USA, 52 cases were cured successfully and 54 died, the mortality being 50.94%. Conclusion:TCM-WM treatment could elevate the therapeutic effect in treating MODS, the mechanism might be through improving the hemodynamic and hemorrheologic condition of patients to relieve nail-fold microcirculation disorder; influencing the levels of cytokine and inflammatory mediator, so as to alleviate the systemic inflammatory reaction, it might also abate the inhibited condition of gastro-intestinal motility, alleviate the intestinal flora imbalance, prevent intestinal bacteria and endotoxin malposition, and protect cells from peroxidation.

  1. Systems-Pharmacology Dissection of Traditional Chinese Medicine Compound Saffron Formula Reveals Multi-scale Treatment Strategy for Cardiovascular Diseases

    Science.gov (United States)

    Liu, Jianling; Mu, Jiexin; Zheng, Chunli; Chen, Xuetong; Guo, Zihu; Huang, Chao; Fu, Yingxue; Tian, Guihua; Shang, Hongcai; Wang, Yonghua

    2016-01-01

    Cardiovascular diseases (CVDs) have been regarding as “the world’s first killer” of human beings in recent years owing to the striking morbidity and mortality, the involved molecular mechanisms are extremely complex and remain unclear. Traditional Chinese medicine (TCM) adheres to the aim of combating complex diseases from an integrative and holistic point of view, which has shown effectiveness in CVDs therapy. However, system-level understanding of such a mechanism of multi-scale treatment strategy for CVDs is still difficult. Here, we developed a system pharmacology approach with the purpose of revealing the underlying molecular mechanisms exemplified by a famous compound saffron formula (CSF) in treating CVDs. First, by systems ADME analysis combined with drug targeting process, 103 potential active components and their corresponding 219 direct targets were retrieved and some key interactions were further experimentally validated. Based on this, the network relationships among active components, targets and diseases were further built to uncover the pharmacological actions of the drug. Finally, a “CVDs pathway” consisted of several regulatory modules was incorporated to dissect the therapeutic effects of CSF in different pathological features-relevant biological processes. All this demonstrates CSF has multi-scale curative activity in regulating CVD-related biological processes, which provides a new potential way for modern medicine in the treatment of complex diseases. PMID:26813334

  2. Effects of Traditional Chinese Medicine on Chemotherapy-Induced Myelosuppression and Febrile Neutropenia in Breast Cancer Patients

    Directory of Open Access Journals (Sweden)

    Huan Tian

    2015-01-01

    Full Text Available Title. Chemotherapy-induced myelosuppression lowers the quality of life in breast cancer patients and causes many complications. Traditional Chinese Medicine (TCM is a widely used complementary and alternative medicine therapies. Objective. To study whether TCM can reduce the incidence of chemotherapy-induced leukopenia, neutropenia, and febrile neutropenia (FN in breast cancer patients. Methods. The data were analyzed retrospectively between patients who received TCM treatment (group 1, n=453 and patients who did not receive TCM treatment (group 2, n=359. Significant risk factors associated with the occurrence of chemotherapy-induced leukopenia, neutropenia, and FN were identified using multivariate analysis. Propensity score-matched patients were analyzed to adjust for any baseline differences. Results. Group 1 patients had a significantly lower rate of chemotherapy-induced severe leukopenia, neutropenia, and FN, compared with group 2 (43% versus 71%, P<0.0001, 72% versus 78%, P=0.005, 6% versus 24%, P<0.0001, resp.. Multivariate analysis revealed that chemotherapy regimens containing anthracyclines combined with paclitaxel or docetaxel were the most significant predictor. Subgroup analysis indicated that TCM treatment showed benefit in relieving chemotherapy-induced leukopenia and FN in most chemotherapy regimens. Conclusions. TCM treatment could lower the risk of severe chemotherapy-induced leukopenia, neutropenia, and FN in breast cancer patients.

  3. Assessment of effects of a formula used in the traditional Chinese medicine (Buzhong Yi Qi Wan) on the morphologic and osmotic fragility of red blood cells

    OpenAIRE

    Tania S. Giani; Paoli,Severo de; Presta,Giuseppe A.; Adalgisa I. Maiworm; Santos-Filho, Sebastião D.; Fonseca,Adenilson S.; Bernardo-Filho, Mario

    2007-01-01

    Buzhong Yi Qi Wan (BYQW) is a combination of some medicinal herbs widely used in traditional Chinese medicine to treat blood, spleen and stomach disorders. Morphometric analysis and osmotic fragility assay have been used to evaluate changes on membrane integrity of red blood cells. The aim of this work was to evaluate the effect of an aqueous BYQW extract on the morphology and osmotic fragility of red blood cells. Blood samples were treated with BYQW extract, quantitative/qualitative morpholo...

  4. Study of Controlling Acute Hemorrhage from Esophageal Varices Rupture with Technique of Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Objective: To find a method for inducing Chinese drugs to adhere to the esophageal mucosa to control bleeding from ruptured esophageal varices. Methods: The site and time that the Chinese drugs adhere to esophageal mucosa were observed in 30 healthy volunteers under the specific condition of standing and lying posture. Seventy episodes bled with ruptured esophageal varices patients (treated group 36 episodes in 25 patients and control group 34 episodes in 27 patients) suffering from cirrhosis of liver were treated by the technique of drug adhesion. Results: (1) The adhesion of Chinese hemostatic drugs remained in the lower segment of esophagus for more than 15 minutes in lying posture, longer than that in standing posture (P0.05). Conclusion: This drug adhesion technique provides a new approach to control hemorrhage from ruptured esophageal varices.

  5. Published the papers of HPLC-MS analysis—Traditional Chinese medicine

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Medicinal materials Ma Chenchen, Li Bailin, Ou Jie, Wang Jing, Zhao Junhong. Detection of N-acyl-homoserine lactones class signal molecules of quorum sensing secreted by bacteria using high performance liquid chromatography-mass spectrometry/ mass spect

  6. Survey of Current Experimental Studies of Effects of Traditional Chinese Medicine on Peripheral Nerve Regeneration

    Institute of Scientific and Technical Information of China (English)

    WU Qun-li; LIANG Xiao-chun

    2006-01-01

    The repairing and regeneration of peripheral nerves is a very complex biological and cytological process, its mechanism is unclear so far, and thus results in the lack of specific and effectual therapy and medicament. Chinese herbs and their effective components have their own inimitable predominance in promoting peripheral nerve regeneration, such as their multi-factorial, multi-target and multi-functional action, abundant source, inexpensive, etc. In this paper, the experimental studies reported in recent 5 years concerning the effects of Chinese herbs or their active components on peripheral nerve repairing and regeneration are reviewed in respects of the integral level, cellular level, molecular level and gene level.

  7. Speciation analysis of iron in traditional Chinese medicine by flame atomic absorption spectrometry.

    Science.gov (United States)

    Li, Shun-Xing; Deng, Nan-Sheng

    2003-04-24

    In view of octanol, a long-chain alkanol, resembled as the configuration of carbohydrate and adipose in human body, the octanol-solubility and water-solubility were used to define the species of iron in medicine, to identify the lipophily and bioavailability of coordinated iron complex, and octanol-water system was adopted to study the distribution of iron in decoction of eight single medicines and compatibility of semen persicae and flos carthami in stomach and intestine. To study the effect of compatibility of medicines, the different acidity of stomach and intestine on the species of iron in phytomedicine decoction, the total concentration, octanol- and water-solubility concentration of iron in medicinal materials or decoctions under gastric and intestinal acidity, were determined, respectively, by flame atomic absorption spectrometry, analyzed and compared. The different acidity of digestive site, the different composition of medicine, and the compatibility of medicines, have greatly affected the species of iron, the pharmacological activity of coordinated iron complex in decoctions. Such factors, especially the concentration of octanol-solubility iron, could be the basis of the dosage to avoid iron overload.

  8. 从生物全息律谈中西医解剖学的相对统一%Anatomic Relative consistence of Western Medicine with Traditional Chinese Medicine in View of Biological Holographic Law

    Institute of Scientific and Technical Information of China (English)

    张勇; 唐业宁

    2001-01-01

    There is an essential distinction,which results from different starting points in the investigation of human body,between traditional Chinese medicine and western medicine in theory. Following up reverse route of study,investigations in traditional Chinese medicine and western medicine are usually carried out at different anatomic levels.In the present paper the comparative analysis of the fundamentals of traditional Chinese medicine and western medicine has been performed in view of biological holographic law,and their consistence has been examined from the viewpoint of anatomy. A new idea to study the fundamental theory of the combination of traditional Chinese medicine and western medicine has been proposed.%中医和西医在理论上存在着本质的区别,两者的区别在于各自对人体研究的起点不同,在研究思路上呈现逆向过程,且各自研究人体不同的解剖层次。这里运用生物全息律的观点和方法,对中西医基础理论进行比较分析,从解剖学角度探讨其统一性,为中西医结合基础理论的研究提出了一个新的思路。

  9. Influence of Vinegar and Wine Processing on the Alkaloid Content and Composition of the Traditional Chinese Medicine Corydalis Rhizoma (Yanhusuo

    Directory of Open Access Journals (Sweden)

    Hongwei Wu

    2014-08-01

    Full Text Available Corydalis Rhizoma is the dried tuber of Corydalis yanhusuo W.T. Wang which is used in traditional Chinese medicine for pain relief and blood activation. Before being used in the clinics, C. yanhusuo is traditionally processed through dry-frying or frying with vinegar, wine or salt. In this study, eleven alkaloids from Corydalis Rhizoma, namely protopine (1, α-allocryptopine (2, tetrahydrocolumbamine (3, coptisine (4, palmatine (5, berberine (6, dehydrocorydaline (7, d,l-tetrahydropalmatine (8, tetrahydroberberine (9, corydaline (10 and tetrahydrocoptisine (11 were simultaneously quantified using a newly developed high performance liquid chromatography-diode array detector (HPLC-DAD method. The influence of vinegar and wine processing on the content of the main alkaloids of Corydalis Rhizoma was investigated. For this purpose, two common formulations with clinical application, namely the water decoction of Corydalis Rhizoma and its formula Jin Ling Zi San (combination of Corydalis Rhizoma and Toosendan Fructus were studied. In the two water decoctions, wine and vinegar processing increased the amount of tertiary alkaloids. The differences were more pronounced for Jin Ling Zi San, in which case the content of all tertiary alkaloids (compounds 1, 2, 3, 8, 9, 10, 11 was increased by wine processing.

  10. 《国医旬刊》及其中西医汇通理念%Ten-day Periodical of Traditional Chinese Medicine and its concept of confluence of Chinese and west-ern medicine

    Institute of Scientific and Technical Information of China (English)

    张孙彪; 王尊旺

    2016-01-01

    厦门国医专门学校1934年7月创办的《国医旬刊》,在近代中西医交会之际,刊载了众多中医师以西医知识阐释传统中医的文章,开启了当地中医界探索中西医汇通的学术路径.该刊坚持"发扬国医学术""融贯中西学说"的办刊理念,破除"科学"迷信,树立中医信念,用西医解剖知识佐证中医气化与脏腑理论,正视中西医差异,力戒盲目汇通,表现出学术的继承性和时代的进步性.所刊论说虽失之于穿凿附会、过誉中医之长,但对中西医汇通所做的探索和留下的经验,应能帮助当代学人更好地处理中西医学的关系,更加自觉地应对未来的挑战.%The Ten-day Periodical of Traditional Chinese Medicine, a TCM Journal founded by the Xiamen Professional School of Traditional Chinese Medicine in July 1934, had published a lot of essays writ-ten by many TCM physicians that interpret the concept of traditional Chinese medicine by western medicine, offering the academic way of probing confluence of Chinese and Western Medicine in Xiamen. The aim of the Journal includes "developing TCM academy" and the"confluence of TCM with western medicine", the exploration of TCM and the penetration of Chinese and western medicine, and getting rid of blind faith on"science" to set up the belief of TCM and to prove the ideas of visceral theory and its gasification by the an-atomical knowledge of western medicine. The Journal envisaged the difference between the TCM and WM, avoided blind convergence, representing the academic inheritance and progress of the era. Although the es-says published might have made a forced analogy by over-praising TCM, however, its exploration and con-vergence of TCM and the experiences are helpful to modern scholars to properly manage the relation of TCM and WM to face the future challenge consciously.

  11. Traditional Chinese Medicine from a macro point of view-application of system theory

    Institute of Scientific and Technical Information of China (English)

    LI Zhen

    2011-01-01

    System concept is the core(essence) of TCM. Base on system concept, we will much easier to learn TCM text book and successful clinical cases of 5000 years experience. It is the key to improve effective rate. As an individual treatment approach, this complementary medicine of conventional medicine play more and more important role in our modem life. TCM treatment should be involved not only in our early stage but also in our daily life. This can reduce national medical cost and improve residents' health condition significantly.

  12. Post-modernization of traditional Chinese medicine%中医应适当后现代化

    Institute of Scientific and Technical Information of China (English)

    严暄暄; 阿清湖

    2012-01-01

    后现代主义认为知识是社会构建的结果,是一定文化、社会背景下的阶段性认知.因而,中医也是一种被构建的“话语”.后现代主义提供了一种新的思路来重新阐释中医,思辨中医的科学性与现代化、西化、中西医之异同与结合、中医的未来发展等中医界里经典命题.笔者认为中医应适当地后现代化,摆脱唯科学主义和动物实验方法的桎梏,清醒地认识到中医西化背后的文化霸权的影响,消除简单的二元对立,回归中医的普世价值,积极而审慎地把中医发展成后现代医学.%Post-modernism claims that knowledge is the outcome of social construction which is conducted in the context of certain culture and social history. In this sense, traditional Chinese medicine (TCM) also should be considered as a 'discourse' . Post-modernism offers an innovative thinking way to interpret TCM and to work out its related classical puzzles about scientificalness, modernization, westernization, integration with Western Medicine, and the future development. The author advocates the post-modernization of TCM to get rid of the drawbacks of scientism and animal experimental researches, to overcome the oversimplified dualism, to unveil the effects of intellectual hegemony on westernization of TCM, to recall the ultimate values of TCM, and to properly transform TCM into a post-modernized medicine.

  13. Two Traditional Chinese Medicines Curcumae Radix and Curcumae Rhizoma: An Ethnopharmacology, Phytochemistry, and Pharmacology Review

    Science.gov (United States)

    Zhou, Yang; Xie, Meng; Song, Yan; Wang, Wenping; Zhao, Haoran; Tian, Yuxin; Wang, Yan; Bai, Shaojuan; Zhao, Yichen; Chen, Xiaoyi; She, Gaimei

    2016-01-01

    Curcumae Rhizoma, known as Ezhu (Chinese: 莪术), and Curcumae Radix, known as Yujin (Chinese: 郁金), are different plant parts coming from three same species according to China Pharmacopoeia. Actually, they are used in different ways in TCM clinical treatment. Curcumae Rhizoma is mainly used as antitumor drug, while Curcumae Radix has been used as antidepressant and cholagogue. Curcumae Rhizoma and Curcumae Radix are confused in variety and source, even in clinical trials by some nonprofessional workers. So it is important for us to make them clear. This review is aimed at summarizing the ethnopharmacology, phytochemical, and pharmacological differences between Curcumae Radix and Curcumae Rhizoma by SciFinder, CNKI, and so on, to use them exactly and clearly. Further studies on Curcumae Rhizoma and Curcumae Radix can lead to the development of new drugs and therapeutics for various diseases on the basis of the TCM theory. PMID:27057197

  14. 中医药消费者信心指数研究%Research on Consumer Confidence Index of Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    邱鸿钟; 闫志来; 梁瑞琼

    2016-01-01

    该研究首先提出了中医药消费者信心指数的概念,并利用全球知名网络调查平台(调查星)进行随机调查所获得的数据,建立了由满意指数和预期指数两个维度构成的中医药消费者信心指数模型,结果显示,中医药消费者信心指数调查问卷设计合理,方法可行,结论合理,为中医药消费市场调查提供了一个方便实用的分析工具。%At first, this paper puts forward the concept of consumer confidence index of traditional Chinese medicine, and use the global well-known network platform (survey) data obtained by the random survey, established by the satisfaction in-dex and expectations index two dimensions of consumer confidence index model of traditional Chinese medicine.The results showed, Consumer confidence index survey of Chinese medicine questionnaire design is reasonable, the method is feasible and reasonable conclusion, for the consumer market survey of traditional Chinese medicine provides a convenient and prac-tical analysis tools.

  15. 治疗哮喘中药有效成分研究%Research on Effective Ingredients of Traditional Chinese Medicine in Asthma Treatment

    Institute of Scientific and Technical Information of China (English)

    侯光菡; 郭宏伟; 邓家刚

    2012-01-01

    近年来,中药有效成分在治疗哮喘方面取得了许多成果,中药化学成分十分复杂,在治疗哮喘中显示多种药理机制.文章归纳和分析了治疗哮喘中药的有效成分,并对不同类型中药的有效成分的作用机制进行了总结,以期找到相同类型有效成分作用机制的共性.%In recent year, the effective ingredients of traditional Chinese medicine have reached many achievements in asthma treatment. The chemical composition of the traditional Chinese medicine is complicated that it shows a lot of pharmacological mechanisms in the treatment of asthma. This paper summarizes and analyzes the effective ingredients for the treatment of asthma in Chinese medicine, and the mechanism of the effective ingredients in different kinds of traditional Chinese medicine are summarized. In order to finrt the mechanism of the same tapy effective ingredients in common.

  16. WHO西太区与世界中医药学会联合会中医名词术语国际标准比较研究:内科疾病(一)%Comparative study on WHO Western Pacific Region and World Federation of Chinese Medicine Societies international standard terminologies on traditional medicine: Diseases in Internal Medicine (Part 1)

    Institute of Scientific and Technical Information of China (English)

    李照国

    2012-01-01

    Currently in English translation of terms concerning diseases in traditional Chinese medicine (TCM),three major approaches are often used,namely,literal translation,loan words from modern medicine and transliteration.

  17. The Traditional Medicine and Modern Medicine from Natural Products.

    Science.gov (United States)

    Yuan, Haidan; Ma, Qianqian; Ye, Li; Piao, Guangchun

    2016-04-29

    Natural products and traditional medicines are of great importance. Such forms of medicine as traditional Chinese medicine, Ayurveda, Kampo, traditional Korean medicine, and Unani have been practiced in some areas of the world and have blossomed into orderly-regulated systems of medicine. This study aims to review the literature on the relationship among natural products, traditional medicines, and modern medicine, and to explore the possible concepts and methodologies from natural products and traditional medicines to further develop drug discovery. The unique characteristics of theory, application, current role or status, and modern research of eight kinds of traditional medicine systems are summarized in this study. Although only a tiny fraction of the existing plant species have been scientifically researched for bioactivities since 1805, when the first pharmacologically-active compound morphine was isolated from opium, natural products and traditional medicines have already made fruitful contributions for modern medicine. When used to develop new drugs, natural products and traditional medicines have their incomparable advantages, such as abundant clinical experiences, and their unique diversity of chemical structures and biological activities.

  18. Analysis of influence factors on pharmacological action of Traditional Chinese Medicine%影响中药药理作用的因素分析

    Institute of Scientific and Technical Information of China (English)

    周二付

    2015-01-01

    对中药药理作用产生影响的因素有很多,如环境因素、机体因素以及药物因素.本文详细的对中药药理作用的影响因素进行探讨和分析,为我国现代医疗科学研究中药药理提供科学高效的价值意义,旨在为同行业者提供一个参考依据.%There are many factors that influence the pharmacological effects of Traditional Chinese Medicine, such as environmental factors and organic factors, drug factors. It investigated and analyzed the influential factors on Chinese medicine pharmacological effects with the value significance in order to provide scientific and efficient Chinese medicine for pharmacological research of modern medical science and provide a reference for the industry.

  19. 中医证候的结构化研究%Structural Study on Syndromes of Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    孙喜灵; 姜伟炜; 张晓林; 刘琳; 王斌胜; 王云慧; 刘孟安

    2013-01-01

    Based on the theory of topological structure within the syndrome of Traditional Chinese Medicine, the high order multi and nonlinear structure of syndromes can be cracked, and the panorama of complex and changeable syndrome can be shown, revealing dynamic evolving of syndromes sub-sets, inter-changing between main and secondary symptoms, precise correspondence with prescriptions and medicines, and the scientific connotation of dynamic evocating rule. Using syndrome structured theory to analyze ancient medical records, formula as well as clinical research data, can deepen our understanding of Chinese medicine formula, enrich knowledge of health care and illness prevention, so as to promote treatment based on syndrome differentiation and TCM theory development.%基于证候理论内蕴拓扑结构的理论和方法,可以破解证候高阶多维的非线性结构,展现证候复杂多变的全貌,阐明证候动态演化过程中子集合的衍生规律,以及证候动态演化子集合主症与次症的变化规律,实现证候动态演化子集合与治则治法和方药的精准对应,揭示出证候动态演化规律的科学内涵.运用证候结构化的理论数据,通过古代名医医案和方剂证候分析的文献数据,以及临床案例证候的数据,可以实现中医理法方药知识的创新,带动养生保健和预防知识的创新,从而促进辨证论治水平的大幅度提高,促进中医学理论的发展.

  20. Screening of Natural Antioxidants from Traditional Chinese Medicinal Plants Associated with Treatment of Rheumatic Disease

    OpenAIRE

    Hua-Bin Li; Feng-Lin Song; En-Qin Xia; Yuan Zhang; Xiang-Rong Xu; Lei Kuang; Ren-You Gan

    2010-01-01

    In order to find new sources of natural antioxidants, the antioxidant capacities of 50 medicinal plants associated with treatment of rheumatic diseases were systemically evaluated using the ferric-reducing antioxidant power (FRAP) and Trolox equivalent antioxidant capacity (TEAC) assays, and their total phenolic contents were measured by the Folin–Ciocalteu method. Their antioxidant activities of some of these plants were analyzed for the first time. The FRAP and TEAC assay results suggested ...

  1. 中药预防自然流产的研究进展%Research progress on prevention and treatment of natural abortion with traditional Chinese medicine

    Institute of Scientific and Technical Information of China (English)

    王平; 刘善新; 孙铁锋; 王杰

    2015-01-01

    Western medicine considers that abortion related to genetic factors,maternal factors,immunefactors and other factors. Traditional Chinese medicine believes that the kidney is the most fundamental factors of abortion. This paper gave a review of spontaneous abortion mainly from natural abortion pathogenesis,treatment,and prevention methods,which provided a direction for traditional Chinese medicine in the treatment of spontaneous abortion.%西医认为自然流产多与遗传因素、母体因素、免疫因素以及其他因素有关。中医认为肾虚是流产最根本的因素。本文主要从自然流产的发病机制、治疗方法以及防护方法进行阐述,为开发中医中药治疗自然流产提供方向。

  2. The Investigation on Traditional Chinese Medicine Treatment of External Humeral Epicondylitis%肱骨外上髁炎的中医治疗探析

    Institute of Scientific and Technical Information of China (English)

    李春光

    2015-01-01

    Objective The Traditional Chinese medicine treatment of external humeral epicondylitis is to be investigated. Methods Choose 42 patients of external humeral epicondylitis who are treated in hospital from September 2013 to October 2014 and cure them with traditional Chinese medicine treatment, including both internal and external traditional Chinese medicine treatment as wel as non-drug therapy. And then observe the treatment efficiency. Results With the treatment of acupuncture,massage,external application as wel as oral-taking of traditional Chinese medicine,al of 42 patients’ il ness symptoms have been relieved; thus,such a treatment approach is quite effective and it has statistic value(P<0.05).Conclusion Traditional Chinese medicine treatment is conducive to eliminating spasm of joints and its surround tissue,in addition,it is effective to cure inflammation and restore the stress and tension balance of elbow,therefore,the traditional Chinese medicine treatment of external humeral epicondylitis is quite worthy to be clinical y promoted and applied.%目的:探讨肱骨外上髁炎的中医治疗探析。方法选取2013年9月~2014年10月我院接诊的42例肱骨外上髁炎患者,全部采用中医治疗方法,包括中药内治、中药外治以及非药物疗法,观察患者的治疗效果。结果42例患者经过中医针灸、推拿、中药外敷、中药内服等治疗后症状缓解,治疗效果显著,有统计学意义(P<0.05)。结论中医治疗肱骨外上髁炎能够解除关节与周围组织的痉挛,消除炎症,恢复肘关节的应力和张力平衡。

  3. Indispensable value of clinical trials in the modernization of traditional Chinese medicine: 12 years' experience at CUHK and future perspectives.

    Science.gov (United States)

    Liang, Willmann; Yew, David T; Hon, Kam Lun; Wong, Chun Kwok; Kwok, Timothy C Y; Leung, Ping Chung

    2014-01-01

    The last decade has seen a wealth of information reporting the beneficial effects of Chinese herbal medicines. While a lot more studies were done using in vitro and in vivo research platforms, much fewer investigations were conducted according to evidence-based requirements in clinical settings. The Institute of Chinese Medicine at the Chinese University of Hong Kong (CUHK) has had the opportunity to collaborate with clinicians over the years to initiate and conduct dozens of clinical trials investigating and verifying the therapeutic values of Chinese herbs in selected disease conditions. Of the many disorders, we chose to focus on those that are known for their difficulties achieving perfect results with conventional treatment methods. Examples include non-healing ulcers, allergic conditions, degenerative diseases and cancer. Protective effects of the herbs in such chronic diseases as coronary artery disease and osteoporosis were also part of our focus. Even in healthy individuals and those recovering from chemotherapy, Chinese herbs could help with the immune system and were studied in our clinical trials as well. This paper aims to highlight the important findings from these clinical studies while at the same time, stressing the indispensable value of clinical trials in modernizing the use of Chinese herbs in present-day medicine.

  4. Systematic Evaluation on Clinical Efficacy of External Application of Traditional Chinese Medicine in Treatment of Breast Hyperplasia

    Directory of Open Access Journals (Sweden)

    Yan-hong Lyu

    2015-12-01

    Full Text Available Abstract Objective: To evaluate the clinical efficacy of external application of traditional Chinese medicine (TCM in the treatment of breast hyperplasia. Methods: Randomized controlled clinical trial literatures on external application of TCM in the treatment of breast hyperplasia published in PubMed, Excerpta Medica Database (EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL , China National Knowledge Infrastructure Database (CNKI and Chinese Biomedical Abstract Database (CBM from January 2000 to August 2015 were retrieved, and screened by researchers to data extraction. RevMan 5.3 was applied for Meta analysis. Results: A total of 15 clinical trials with 2 107 patients with breast hyperplasia were included, in which 1 151 were divided into treatment group treated with external application of TCM while 956 into control group. Meta analysis indicated that the clinical response rate and clinical symptom score improvement (lump size as well as serum levels of estradiol (E2, progesterone (P and prolactin (PRL in treatment group were superior to the control group and the differences were statistically significant (P<0.05. Although external application of TCM had a tendency of alleviating clinical symptom (lump pain, hardness and range as well as complicated symptoms, there was no statistically significant difference between two groups (P>0.05. Conclusion: External application of TCM, to some extent, can improve the clinical efficacy in the treatment of breast hyperplasia, and it is necessary to carry out higher-quality, multicenter, large-scale, prospective and double-blind clinical experiments for further validation.

  5. Traditional chinese medicine Xuebijing treatment is associated with decreased mortality risk of patients with moderate paraquat poisoning.

    Directory of Open Access Journals (Sweden)

    Ping Gong

    Full Text Available Paraquat poisoning causes multiple organ injury and high mortality due to severe toxicity and lack of effective treatment. Xuebijing (XBJ injection, a traditional Chinese medicine preparation of five Chinese herbs (Radix Salviae Miltiorrhiae, Rhizoma Chuanxiong, Flos Carthami, Angelica Sinensis and Radix Paeoniae Rubra, has an anti-inflammatory effect and is widely used in the treatment of sepsis. This retrospective study was designed to evaluate the effects of XBJ combined with conventional therapy on mortality risk of patients with acute paraquat poisoning. Out of 68 patients, 27 were treated with conventional therapy (control group and 41 were treated with intravenous administration of XBJ (100 ml, twice a day, up to 7 days plus conventional therapy (XBJ group. Vital organ function, survival time within 28 days and adverse events during the treatment were reviewed. Results indicated that XBJ treatment significantly increased median survival time among patients ingesting 10-30 ml of paraquat (P=0.02 compared with the control group. After adjustment for covariates, XBJ treatment was associated significantly with a lower mortality risk (adjusted HR 0.242, 95% CI 0.113 to 0.516, P=0.001 compared with the control group. Additionally, compared with Day 1, on Day 3 the value of PaO2/FiO2 was significantly decreased, and the values of serum alanine aminotransferase, creatinine and troponin T were significantly increased in the control group (all P<0.05, but these values were significant improved in the XBJ group (all P<0.05. Only one patient had skin rash with itch within 30 minutes after injection and no severe adverse events were found in the XBJ group. In conclusion, XBJ treatment is associated with decreased mortality risk of patients with moderate paraquat poisoning, which may be attributed to improved function of vital organs with no severe adverse events.

  6. Effectiveness of traditional Chinese medicine as an adjunct therapy for Parkinson's disease: a systematic review and meta-analysis.

    Directory of Open Access Journals (Sweden)

    Guoxin Zhang

    Full Text Available Idiopathic Parkinson disease (PD is a common neurodegenerative disease that seriously hinders limb activities and affects patients' lives. We performed a meta-analysis aiming to systematically review and quantitatively synthesize the efficacy and safety of traditional Chinese medicine (TCM as an adjunct therapy for clinical PD patients.An electronic search was conducted in PubMed, Cochrane Controlled Trials Register, China National Knowledge Infrastructure, Chinese Scientific Journals Database and Wanfang data to identify randomized trials evaluating TCM adjuvant therapy versus conventional treatment. The change from baseline of the Unified Parkinson's Disease Rating Scale score (UPDRS was used to estimate the effectiveness of the therapies.Twenty-seven articles i