WorldWideScience

Sample records for chinese materia medica

  1. [A accurate identification method for Chinese materia medica--systematic identification of Chinese materia medica].

    Science.gov (United States)

    Wang, Xue-Yong; Liao, Cai-Li; Liu, Si-Qi; Liu, Chun-Sheng; Shao, Ai-Juan; Huang, Lu-Qi

    2013-05-01

    This paper put forward a more accurate identification method for identification of Chinese materia medica (CMM), the systematic identification of Chinese materia medica (SICMM) , which might solve difficulties in CMM identification used the ordinary traditional ways. Concepts, mechanisms and methods of SICMM were systematically introduced and possibility was proved by experiments. The establishment of SICMM will solve problems in identification of Chinese materia medica not only in phenotypic characters like the mnorphous, microstructure, chemical constituents, but also further discovery evolution and classification of species, subspecies and population in medical plants. The establishment of SICMM will improve the development of identification of CMM and create a more extensive study space.

  2. [Substance basis research on Chinese materia medica is one of key scientific problems of inheriting, development and innovation of Chinese materia medica].

    Science.gov (United States)

    Yang, Xiu-wei

    2015-09-01

    The compound Chinese materia medica is the medication pattern of the traditional Chinese medicine for the disease prevention and treatment. The single Chinese materia medica (mostly in decoction pieces) is the prescription composition of the compound Chinese materia medica. The study of the effective substance basis of Chinese materia medica should be based on the chemical compositions of the compound Chinese materia medica as an entry point considering the different status of "Monarch, Minister, Assistant, and Guide" for a certain single Chinese materia medica in the different compound Chinese materia medica while substance basis research of a certain single Chinese materia medica should be a full component analysis as well as both stable and controllable quality. Substance basis research on Chinese materia medica is one of key scientific problems of inheriting, development and innovation of Chinese materia medica.

  3. [Management of Chinese materia medica market based on information asymmetry].

    Science.gov (United States)

    Yang, Guang; Wang, Nuo; Guo, Lan-Ping; Wang, Yong-Yan; Huang, Lu-Qi; Liu, Jin-Xin

    2013-12-01

    Pharmaceutical market is a typical market with information asymmetry, and which can lead to "lemons" problem. In all developed countries, firms must receive regulatory approval to market a pharmaceutical product. Such administrative department including SFDA, EMA, FDA and so on. Chinese materia medica is a special part of pharmaceutical market in China. The management of Chinese materia medica is a special challenge in China.

  4. [Probe into monitoring mechanism of Chinese materia medica resources].

    Science.gov (United States)

    Zhang, Xiao-Bo; Li, Da-Ning; Guo, Lan-Ping; Lu, Jian-Wei; Sun, Li-Ying; Huang, Lu-Qi

    2013-10-01

    Focusing on the problems of Chinese materia medica resources,and combining with the national Chinese materia medica resources survey, the paper probes into monitoring mechanism of Chinese materia medica resources. The establishment of the monitoring mechanism needs one organization and management agencies to supervise and guide monitoring work, one network system to gather data information, a group of people to perform monitoring work, a system of technical methods to assure monitoring work scientific and practical, a series of achievements and products to figure out the methods for solving problems, a group of monitoring index system to accumulate basic data, and a plenty of funds to keep normal operation of monitoring work.

  5. [Consideration for understanding and developing Chinese materia medica].

    Science.gov (United States)

    Yin, Zhong

    2008-02-01

    To understand and develop Chinese materia medica is a matter not only dealing with progresses of science and technology but also with that of bio-science. In the area of life-science, the activity of human life-science is the most complicated one which is far away to be satisfactorily explained with existing knowledge of science. Therefore, it is much insufficient to explain and qualify the interreaction between Chinese materia medica and process of human-life with knowledge of general science and non-fully developed bioscience. To understand and develop Chinese materia medica is also matter dealing with many issues of social science. In terms of epistemology, it is necessary to consider how to make some social adjustment for scientific practice and drug registration of Chinese materia medica, under precondition of balance among science, life-science, technology, ethics and philosophy.

  6. The current global status of Chinese materia medica.

    Science.gov (United States)

    Liu, Xinmin; Zou, Jiangqiang; Sheng, Zhixiang; Su, Guangqiang; Chen, Shilin

    2009-10-01

    The Chinese government has recently established a national project to improve the standards of Chinese Materia Medica (CMM) products, particularly regarding their quality control and safety evaluation, in order to promote modernization and increase international trade. In 2006, the global sales value of Chinese medicinal products increased to 20 billion US$, and the export value of CMM was up to more than 1 billion US$. However, the standard of these products still needs to be improved to meet the more stringent requirements of the international markets. Over the past decade we have witnessed the increasing growth in popularity of health foods and herbal medicinal products, especially Chinese Materia Medica products (CMM).

  7. [Construction of biopharmaceutics classification system of Chinese materia medica].

    Science.gov (United States)

    Liu, Yang; Wei, Li; Dong, Ling; Zhu, Mei-Ling; Tang, Ming-Min; Zhang, Lei

    2014-12-01

    Based on the characteristics of multicomponent of traditional Chinese medicine and drawing lessons from the concepts, methods and techniques of biopharmaceutics classification system (BCS) in chemical field, this study comes up with the science framework of biopharmaceutics classification system of Chinese materia medica (CMMBCS). Using the different comparison method of multicomponent level and the CMMBCS method of overall traditional Chinese medicine, the study constructs the method process while setting forth academic thoughts and analyzing theory. The basic role of this system is clear to reveal the interaction and the related absorption mechanism of multicomponent in traditional Chinese medicine. It also provides new ideas and methods for improving the quality of Chinese materia medica and the development of new drug research.

  8. [Study on sociocultural history of therapeutic efficacy and processing of chinese materia medica].

    Science.gov (United States)

    Zheng, Jin-Sheng

    2006-10-01

    The historical evolving examples of the confirmation of therapeutic efficacy of some Chinese materia medica, the social fashion of using medicine, and the processing methods of Chinese materia medica indicate that the social trend of thoughts, customs and economic factors in different ages affected the various aspects of Chinese materia medica. So, Chinese materia medica possesses very outstanding social and cultural features. Not all the actions of Chinese materia medica recorded came from the experiences of doctors. The understanding level to the nature in different ages decides what kind of drugs they would accept. There are three kinds of drug processing in ancient times: effective medicinal processing, fantastic Taoist processing and invalid trading processing. Based on the study of sociocultural history of therapeutic efficacy and processing of Chinese materia medica. It is crucial that the history and medical literature research on Chinese materia medica and pharmacy should be raised to the position as important as clinical and experiment researches.

  9. [Elementary exploration of the origin and development of marine Chinese materia medica].

    Science.gov (United States)

    Guan, Hua-Shi; Fu, Xian-Jun; Wu, Qiang-Ming; Wang, Chang-Yun; Wang, Yu; Jiang, Deng-Zhao

    2009-05-01

    According to archaeological discoveries, humans began to make use of marine natural resources early in the Palaeolithic era. In the Spring and Autumn period and Warring States period, they began to use marine life as medicines and also had simple cognitions on their efficacy and processing. In the Qin and Han dynasties, people further deepened the understanding of the marine Chinese materia medica and created prescriptions making use of marine drugs. In the Tang and Song period, the number of marine Chinese materia medica species and corresponding prescriptions apparently increased. The cognitions of the property, flavor, efficacy as well as the compatible principle of marine Chinese materia medica was further deepened and the scope of their treatment also significantly expanded. In the Ming and Qing dynasties, the cognition of the marine Chinese materia medica was mainly the conclusions of the previous experience. After the founding of the People's Republic of China (PRC), with the development of science and technologies, the ability of exploiting and utilizing the marine Chinese materia medica by people dramatically increased, and the species of marine Chinese materia medica reached more than one thousand. However, the development of marine Chinese materia medica is confronted with new problems; although the number of species of marine Chinese materia medica increased, the understanding of their property and flavor is obviously lagging behind, which seriously affects the clinical application of marine Chinese materia medica.

  10. [Ecological agriculture: future of Good Agriculture Practice of Chinese materia medica].

    Science.gov (United States)

    Guo, Lan-ping; Zhou, Liang-yun; Mo, Ge; Wang, Sheng; Huang, Lu-qi

    2015-09-01

    Based on the ecological and economic problems in Good Agriculture Practice (GAP) of Chinese material medica, we introduced the origin, concept, features and operative technology of eco-agriculture worldwide, emphasizing its modes on different biological levels of landscape, ecosystem, community, population, individual and gene in China. And on this basis, we analyzed the background and current situation of eco-agriculture of Chinese materia medica, and proposed its development ideas and key tasks, including: (1) Analysis and planning of the production pattern of Chinese material medica national wide. (2) Typical features extraction of regional agriculture of Chinese materia medica. (3) Investigation of the interaction and its mechanism between typical Chinese materia medica in each region and the micro-ecology of rhizosphere soil. (4) Study on technology of eco-agriculture of Chinese materia medica. (5) Extraction and solidification of eco-agriculture modes of Chinese materia medica. (6) Study on the theory of eco-agriculture of Chinese materia medica. Also we pointed out that GAP and eco-agriculture of Chinese material medica are both different and relative, but they are not contradictory with their own features. It is an irresistible trend to promote eco-agriculture in the GAP of Chinese material medica and coordinate ecological and economic development.

  11. [Application of zebrafish model organism in the research of Chinese materia medica].

    Science.gov (United States)

    Chen, Lei; Liu, Yi; Liang, Sheng-Wang

    2012-04-01

    Zebrafish has become an important model organism in many fields of biomedical studies and been increasingly used in Chinese materia medica studies in recent years. This article summarized the achievements and prospect for zebrafish as a pharmacological and toxicological tool in the study and development of Chinese materia medica.

  12. Review of adverse reactions to injections of Chinese materia medica.

    Science.gov (United States)

    Bian, Zhaoxiang; Shang, Hongcai; Cheng, Chungwah; Wu, Taixiang; Li, Youping; Zhang, Boli

    2010-05-01

    Using Chinese Materia Medica (CM) as injections is an innovation that is proving effective in extensive clinical use in Mainland China. However, recent reports have focused on adverse reactions, ignoring the considerable successes of these preparations. In order to achieve balance in the media and in the minds of the public, we suggest the first step is to clarify the concepts of and differences between adverse drug reactions (ADR) and adverse events (AE) for all concerned-the public, medical practitioners, government officials, and lawmakers. Second, the State Food and Drug Administration should raise the requirements for Chinese Materia Medica Injection (CMI) registration and license approval and emphasize the importance of evidence-based CMI development and evidence-based CMI license approval. Thirdly, drug companies and institutions should reinforce basic research about the quality control of herbs and CMI-drug interactions. Fourth, the Government should clarify the legal responsibilities for CMI approval agencies, CMI developers, medical doctors, and patients. Fifth, the medical association and Government should enhance training for health care professionals concerning the usage of CMIs. And finally sixth, State Food and Drug Administration should monitor the content and quality of the directions for use of CMI.

  13. [Application of synthetic biology to sustainable utilization of Chinese materia medica resources].

    Science.gov (United States)

    Huang, Lu-Qi; Gao, Wei; Zhou, Yong-Jin

    2014-01-01

    Bioactive natural products are the material bases of Chinese materia medica resources. With successful applications of synthetic biology strategies to the researches and productions of taxol, artemisinin and tanshinone, etc, the potential ability of synthetic biology in the sustainable utilization of Chinese materia medica resources has been attracted by many researchers. This paper reviews the development of synthetic biology, the opportunities of sustainable utilization of Chinese materia medica resources, and the progress of synthetic biology applied to the researches of bioactive natural products. Furthermore, this paper also analyzes how to apply synthetic biology to sustainable utilization of Chinese materia medica resources and what the crucial factors are. Production of bioactive natural products with synthetic biology strategies will become a significant approach for the sustainable utilization of Chinese materia medica resources.

  14. [Research on nature of Chinese materia medica in view of genetic relationship].

    Science.gov (United States)

    Yang, Hong-Jun; Tang, Shi-Huan; Huang, Lu-Qi; Xiao, Pei-Gen

    2008-12-01

    In this paper, based on analyzing the status quo and key problem of research on nature of Chinese materia medica, we propose the thinking of research on nature of Chinese materia medica in view of genetic relationship. Namely, according to the cue of documents arrangement and data excavation, in certern scope of genetic relationship, difinite the common pharmaco-effect of the same nature of drug, and analyze the chemical composition correlated the nature of drug, further more, reveal the related regularity of nature of Chinese materia medica-pharmaco-effect- chemical composition. Linking the nature of Chinese materia medica, pharmaco-effect and chemical composition will provide original thinking and view angle to break through the key problem of research on nature of Chinese materia medica.

  15. The classification and application of toxic Chinese materia medica.

    Science.gov (United States)

    Liu, Xinmin; Wang, Qiong; Song, Guangqing; Zhang, Guangping; Ye, Zuguang; Williamson, Elizabeth M

    2014-03-01

    Many important drugs in the Chinese materia medica (CMM) are known to be toxic, and it has long been recognized in classical Chinese medical theory that toxicity can arise directly from the components of a single CMM or may be induced by an interaction between combined CMM. Traditional Chinese Medicine presents a unique set of pharmaceutical theories that include particular methods for processing, combining and decocting, and these techniques contribute to reducing toxicity as well as enhancing efficacy. The current classification of toxic CMM drugs, traditional methods for processing toxic CMM and the prohibited use of certain combinations, is based on traditional experience and ancient texts and monographs, but accumulating evidence increasingly supports their use to eliminate or reduce toxicity. Modern methods are now being used to evaluate the safety of CMM; however, a new system for describing the toxicity of Chinese herbal medicines may need to be established to take into account those herbs whose toxicity is delayed or otherwise hidden, and which have not been incorporated into the traditional classification. This review explains the existing classification and justifies it where appropriate, using experimental results often originally published in Chinese and previously not available outside China.

  16. [Discuss on effect of physical environmental factors on nature of Chinese materia medica].

    Science.gov (United States)

    Tang, Shihuan; Yang, Hongjun; Huang, Luqi

    2010-01-01

    Nature of Chinese materia medica is the nucleus in the theory of Chinese material medica, according to the recognition of Traditional Chinese Medicine, which is the character of the drug related on curative effect. Nature and efficacy of a drug is through the medical material, then, physical environment, including the temperature, humidity, atmospheric water, wind, topography, soil, micro-organism, and so on, influence the growth and development of the medical meterial. In this paper, we researched the explanation on nature of Chinese materia medica in the medical books of past dynasties, combined with the modem research, analyzed the relationship between generative reception and physical environmental factors, and discussed the effect of physical environmental factors on nature of Chinese materia medica. We indicated that the formation of Chinese materia medical nature is that the drug receptive the change of physical environmental factors, and resulted by the synthetic action of the factors, such as climate, soil, biology, topography, etc.

  17. Chinese Marine Materia Medica Resources: Status and Potential

    Directory of Open Access Journals (Sweden)

    Xiu-Mei Fu

    2016-03-01

    Full Text Available Chinese marine materia medica (CMMM is a vital part of traditional Chinese medicine (TCM. Compared with terrestrial TCM, CMMM, derived from specific marine habitats, possesses peculiar chemical components with unique structures reflecting as potent pharmacological activities, distinct drug properties and functions. Nowadays, CMMM appears to be especially effective in treating such difficult diseases as cancers, diabetes, cardio-cerebrovascular diseases, immunodeficiency diseases and senile dementia, and therefore has become an important medicinal resource for the research and development of new drugs. In recent years, such development has attracted wide attention in the field of medicine. In this study, the CMMM resources in China were systematically investigated and evaluated. It was found that the historic experiences of Chinese people using CMMM have continuously accumulated over a period of more than 3600 years, and that the achievements of the research on modern CMMM are especially outstanding. By June 2015, 725 kinds of CMMMs from Chinese coastal sea areas have been identified and recorded, covering 1552 organisms and minerals. More than 3100 traditional prescriptions containing CMMMs have been imparted and inherited. However, the number of CMMMs is less than the 8188 terrestrial TCMs, from more than 12,100 medicinal terrestrial plants, animals and minerals. In the future, the research and development of CMMM should focus on the channel entries (TCM drug properties, compatibility, effective ingredients, acting mechanisms, drug metabolism and quality standard. This study reveals the high potential of CMMM development.

  18. Chinese Marine Materia Medica Resources: Status and Potential.

    Science.gov (United States)

    Fu, Xiu-Mei; Zhang, Meng-Qi; Shao, Chang-Lun; Li, Guo-Qiang; Bai, Hong; Dai, Gui-Lin; Chen, Qian-Wen; Kong, Wei; Fu, Xian-Jun; Wang, Chang-Yun

    2016-03-03

    Chinese marine materia medica (CMMM) is a vital part of traditional Chinese medicine (TCM). Compared with terrestrial TCM, CMMM, derived from specific marine habitats, possesses peculiar chemical components with unique structures reflecting as potent pharmacological activities, distinct drug properties and functions. Nowadays, CMMM appears to be especially effective in treating such difficult diseases as cancers, diabetes, cardio-cerebrovascular diseases, immunodeficiency diseases and senile dementia, and therefore has become an important medicinal resource for the research and development of new drugs. In recent years, such development has attracted wide attention in the field of medicine. In this study, the CMMM resources in China were systematically investigated and evaluated. It was found that the historic experiences of Chinese people using CMMM have continuously accumulated over a period of more than 3600 years, and that the achievements of the research on modern CMMM are especially outstanding. By June 2015, 725 kinds of CMMMs from Chinese coastal sea areas have been identified and recorded, covering 1552 organisms and minerals. More than 3100 traditional prescriptions containing CMMMs have been imparted and inherited. However, the number of CMMMs is less than the 8188 terrestrial TCMs, from more than 12,100 medicinal terrestrial plants, animals and minerals. In the future, the research and development of CMMM should focus on the channel entries (TCM drug properties), compatibility, effective ingredients, acting mechanisms, drug metabolism and quality standard. This study reveals the high potential of CMMM development.

  19. Authentication of Chinese Materia Medica decoction dregs, part 1: comparison of morphological and microscopic features of four Chinese Materia Medica before and after decoction.

    Science.gov (United States)

    Wong, Lailai; Liang, Zhitao; Chen, Hubiao; Zhao, Zhongzhen

    2011-04-01

    Chinese Materia Medica (CMM) decoction dregs are the residues of medicinal materials after decoction. Accurate identification of CMM in decoction dregs will be helpful for exploring the causes of poisoning or other medical incidents arising after the ingestion of CMM decoctions. To determine how decoction affects the characteristics used to authenticate specific CMM, a systematic study was carried out. In this study, two pairs of Materia Medica that are commonly confused-namely, Baizhu (Atractylodis Macrocephalae Rhizoma) and Cangzhu (Atractylodis Rhizoma), Baishao (Paeoniae Alba Radix) and Chishao (Paeoniae Rubra Radix)-were chosen for investigation. Each pair of Materia Medica has similar morphology in appearance, but they have different functions in Chinese clinic. After decoction, with regard to gross morphological characters, the results showed that bark and wood could be easily distinguished. The striation of vessels and fibers became more prominent because of the contraction of parenchymatous cells, but the lignified cells did not. As for the microscopic characteristics, the cells with thickened walls, such as stone cells and fibers, were basically stable. Most of the parenchymatous cells were broken. Crystals of calcium oxalate showed no changes as they were insoluble in water. Starch granules were gelatinized and aggregated in parenchymatous cells. Inulins were substantially reduced in number as they dissolved in water during decoction. According to these changes in morphological and microscopic characteristics after decoction, the dregs of two pairs of Materia Medica could be distinguished.

  20. [Hypothesis and application of bimolecular marking methods in Chinese materia medica].

    Science.gov (United States)

    Huang, Lu-qi; Qian, Dan; Deng, Chao

    2015-01-01

    Based on the current shortage of genuine/false authentication and quality evaluation in the molecular identification, and the weak functional gene research in the establishment of two-dimensional molecular markering methods for Chinese materia medica, the authors proposed a new method, the bimolecular marking methods (BIMM) for Chinese materia medica, combining DNA marker and metabolomics marker, that could simultaneously research the species and quality differences at the molecular level at the present stage. The authors introduced the concept, principle, methods, and technical process of BIMM, and summarized the technical advantages in this paper. Meanwhile, the application of BIMM in the identification of multiple sources of Chinese materia medica, years-identification, different locations, elite germplasm research, discovery of new drugs resources, protection of new varieties was also discussed. As a supplement of two-dimensional molecular markering method for Chinese materia medica, BIMM would not only expand connotation of identification of Chinese materia medica but also provide another effective way for quality evaluating.

  1. [Textual research on adulteration of Chinese materia medica in ancient China].

    Science.gov (United States)

    Xie, Jin; Wang, De-Qun

    2013-09-01

    By investigating the mainstream works of herbal classics of successive ages, it is found that adulteration of Chinese materia medica appeared early in ancient China. The main methods of adulteration was producing fraud medicines in the Northern-Southern Dynasties, fake medicines began to appear in the Tang Dynasty, and status of adulteration of Chinese materia medica ran unchecked since the Ming and Qing Dynasty. By statistics, there were 76 kinds of adulteration varieties before the Republican period. The main varieties were precious drugs, animal drugs and artifacts. Commonly methods used in the process included forging and adulterating, dealing with 11 kinds and 68 kinds respectively. Adulteration probably lead to the result of imposing the changes of the used medicinal parts of Herba Pogostemonis; Radix Aconiti Lateralis prepared by adding salt, Radix Angelica Sinensis processed by wine, and Radix Astragalis seu Hedysaris processed with bee honey. However, the root cause of adulteration in Chinese materia medica was the dissociation of professional physician and pharmacist, resulting in the ignorance of medical practitioners became unable to recognize Chinese materia medica; and the immorality of medicinal merchants. Besides, rating the quality of materia medica based on its producing areas without differentiating the false from the genuine may also contribute to this result passively.

  2. [The application of metabonomics in modern studies of Chinese materia medica].

    Science.gov (United States)

    Chen, Hai-Bin; Zhou, Hong-Guang; Yu, Xiao-Yi

    2012-06-01

    Metabonomics, a newly developing subject secondary to genomics, transcriptomics, and proteomics, is an important constituent part of systems biology. It is believed to be the final direction of the systems biology. It can be directly applied to understand the physiological and biochemical states by its "metabolome profile" as a whole. Therefore, it can provide a huge amount of information different from those originating from other "omics". In the modernization of Chinese materia medica research, the application of metabonomics methods and technologies has a broad potential for future development. Especially it is of important theoretical significance and application value in holistic efficacies evaluation, active ingredients studies, and safety research of Chinese materia medica.

  3. [Important application of intestinal transporters and metabolism enzymes on gastrointestinal disposal of active ingredients of Chinese materia medica].

    Science.gov (United States)

    Bi, Xiaolin; Du, Qiu; Di, Liuqing

    2010-02-01

    Oral drug bioavailability depends on gastrointestinal absorption, intestinal transporters and metabolism enzymes are the important factors in drug gastrointestinal absorption and they can also be induced or inhibited by the active ingredients of Chinese materia medica. This article presents important application of intestinal transporters and metabolism enzymes on gastrointestinal disposal of the active ingredients of Chinese materia medica, and points out the importance of research on transport and metabolism of the active ingredients of Chinese materia medica in Chinese extract and Chinese medicinal formulae.

  4. [Essential procedure and key methods for survey of traditional knowledge related to Chinese materia medica resources].

    Science.gov (United States)

    Cheng, Gong; Huang, Lu-qi; Xue, Da-yuan; Zhang, Xiao-bo

    2014-12-01

    The survey of traditional knowledge related to Chinese materia medica resources is the important component and one of the innovative aspects of the fourth national survey of the Chinese materia medica resources. China has rich traditional knowledge of traditional Chinese medicine (TCM) and the comprehensive investigation of TCM traditional knowledge aims to promote conservation and sustainable use of Chinese materia medica resources. Building upon the field work of pilot investigations, this paper introduces the essential procedures and key methods for conducting the survey of traditional knowledge related to Chinese materia medica resources. The essential procedures are as follows. First is the preparation phrase. It is important to review all relevant literature and provide training to the survey teams so that they have clear understanding of the concept of traditional knowledge and master key survey methods. Second is the field investigation phrase. When conducting field investigations, survey teams should identify the traditional knowledge holders by using the 'snowball method', record the traditional knowledge after obtaining prior informed concerned from the traditional knowledge holders. Researchers should fill out the survey forms provided by the Technical Specification of the Fourth National Survey of Chinese Materia Medica Resources. Researchers should pay particular attention to the scope of traditional knowledge and the method of inheriting the knowledge, which are the key information for traditional knowledge holders and potential users to reach mutual agreed terms to achieve benefit sharing. Third is the data compilation and analysis phrase. Researchers should try to compile and edit the TCM traditional knowledge in accordance with intellectual property rights requirements so that the information collected through the national survey can serve as the basic data for the TCM traditional knowledge database. The key methods of the survey include regional

  5. [Research progress on standards of commodity classes of Chinese materia medica and discussion on several key problems].

    Science.gov (United States)

    Yang, Guang; Zeng, Yan; Guo, Lan-Ping; Huang, Lu-Qi; Jin, Yan; Zheng, Yu-Guang; Wang, Yong-Yan

    2014-05-01

    Standards of commodity classes of Chinese materia medica is an important way to solve the "Lemons Problem" of traditional Chinese medicine market. Standards of commodity classes are also helpful to rebuild market mechanisms for "high price for good quality". The previous edition of commodity classes standards of Chinese materia medica was made 30 years ago. It is no longer adapted to the market demand. This article researched progress on standards of commodity classes of Chinese materia medica. It considered that biological activity is a better choice than chemical constituents for standards of commodity classes of Chinese materia medica. It is also considered that the key point to set standards of commodity classes is finding the influencing factors between "good quality" and "bad quality". The article also discussed the range of commodity classes of Chinese materia medica, and how to coordinate standards of pharmacopoeia and commodity classes. According to different demands, diversiform standards can be used in commodity classes of Chinese materia medica, but efficacy is considered the most important index of commodity standard. Decoction pieces can be included in standards of commodity classes of Chinese materia medica. The authors also formulated the standards of commodity classes of Notoginseng Radix as an example, and hope this study can make a positive and promotion effect on traditional Chinese medicine market related research.

  6. [Differences of bi-directional regulative effects between acu-moxibustion and Chinese materia medica interventions].

    Science.gov (United States)

    Cao, Xin; Yu, Zhi; Xu, Bin

    2012-10-01

    Bi-directional regulation is referred to a balancing effect of both acu-moxibustion and Chinese materia medica interventions when the human body is experiencing a hyperactivity or hypoactivity due to abnormal intrinsic or external factors. In the present paper, the authors analyze their identical and different characteristics from: 1) definition; 2) characters of regulative effects of acu-moxibustion therapy: A) differentiation of meridian and zangfu-organs being the basis of treatment, B) four factors (acupoint-location, body's functional state, acupoint-formula and needle-manipulation techniques) dependant, C) entirety regulation, and D) centrotaxis modulation; 3) characters of Chinese materia medica intervention: including a) correspondence between the drug property and the syndrome being the basis of the regulative effect, b) multi-factors [components (antagonist and agonist), combination, dosages and processing quality of Chinese materia medica, and functional state of the human body] dependant, c) entirety regulation, and d) both centrotaxis and deviation adjustment. In one word, the bi-directional regulation effect is one of the basic characteristics of both acu-moxibustion and Chinese materia medica in clinical practice, but their basis and modes for inducing effects are different.

  7. [Application of bioassay in quality control of Chinese materia medica-taking Radix Isatidis as an example].

    Science.gov (United States)

    Yan, Dan; Ren, Yongshen; Luo, Jiaoyang; Li, Hanbing; Feng, Xue; Xiao, Xiaohe

    2010-10-01

    Bioassay, which construct the characteristics consistents with Chinese medical science, is the core mode and methods for the quality control of Chinese materia medica. Taking the bioassay of Radix Isatidis as an example, the contribution, status and application of bioassay in the quality control of Chinese materia medica were introduced in this article, and two key issue (the selection of reference and measurement methods) in the process of establishing bioassay were also explained. This article expects to provide a reference for the development and improvement of the bioassay of Chinese materia medica in a practical manipulation level.

  8. Industry Development and Health of Chinese Materia Medica and Natural Products

    Institute of Scientific and Technical Information of China (English)

    Tianjin Press of Chinese Herbal Medicines

    2010-01-01

    @@ In order to push forward the research and development of innovative drugs, to re-exploit large species, and to invent healthy product, Tianjin Pharmaceutical Association, Tianjin Plant Association, and Tianjin Press of Chinese Herbal Medicines sponsored the meeting “Circum-Bohai Industry Development and Health of Chinese Materia Medica and Natural Products”. It will be held during May 28-30, 2010. Some famous experts will be invited to make speeches and to communicate with participants.

  9. [Data validation methods and discussion on Chinese materia medica resource survey].

    Science.gov (United States)

    Zhang, Yue; Ma, Wei-Feng; Zhang, Xiao-Bo; Zhu, Shou-Dong; Guo, Lan-Ping; Wang, Xing-Xing

    2013-07-01

    From the beginning of the fourth national survey of the Chinese materia medica resources, there were 22 provinces have conducted pilots. The survey teams have reported immense data, it put forward the very high request to the database system construction. In order to ensure the quality, it is necessary to check and validate the data in database system. Data validation is important methods to ensure the validity, integrity and accuracy of census data. This paper comprehensively introduce the data validation system of the fourth national survey of the Chinese materia medica resources database system, and further improve the design idea and programs of data validation. The purpose of this study is to promote the survey work smoothly.

  10. [Study on early-warning of Chinese materia medica price base on ARMA model].

    Science.gov (United States)

    Chang, Feng; Mao, Yang-Dui

    2014-05-01

    This study sets up an early-warning system framework of Chinese materia medica price, using price index as early warning indicator to establish black early-warning model, with indicator of price index volatility and limit line of "price principal". The research divides warning degree into 5 parts named negative heavy warning, negative light warning, no warning, positive light warning and positive heavy warning, with 5 corresponding lights to describe the change level of the medicine price. Then make an early-warning empirical research based on Chengdu Chinese materia medica price index from December in 2010 to October in 2013. ARMA model is applied to forecast index and the result of early-warning is analyzed, and finally farmer households, companies, customers and the government are recommended respectively.

  11. Status and Trends of GAP Base Construction of Chinese Materia Medica in Guangdong Province

    Institute of Scientific and Technical Information of China (English)

    DING Ping; LAI Xiao-ping; XU Hong-hua; DU Qin; WANG Jian-gang; YING Ge; LIAO Hui-jun; DAI Lei; SHAO Yan-hua

    2012-01-01

    It is one of the key points for modernization and internationalization of traditional Chinese medicines to construct the Good Agricultural Practice (GAP) base of Chinese materia medica (CMM).GAP helps to minimize contamination and improve the quality of CMM during the plantation and the production of Chinese crude drugs.In this article,the status and development of CMM production bases of GAP in Guangdong Province,China,are presented.The suggestions upon the problems during the development of GAP for Chinese crude drugs are also provided.

  12. [Current situation of toxicity classification of Chinese materia medica and its research thoughts].

    Science.gov (United States)

    Sun, Wenyan; Hou, Xiujuan; Wang, Bin; Zhu, Yuelan; Zhang, Shuofeng; Chang, Hongsheng; Sun, Jianning

    2012-08-01

    Toxicity of Chinese materia medica (CMM) is an important part of Chinese herbal nature theory. In clinical application, the dosage, time limitation and compatibility of CMM is mainly determined by toxicity. At present, there is no uniform toxicity classification standard for the evaluation of Chinese herbal toxicity. Therefore, it is significant to research toxicity classification of CMM. The current situation of toxicity classification of CMM is reviewed in this paper, and proposed research thoughts are as follows: the measurement of toxicity parameters, the confirmation of poisoning target organs, the investigation on toxic mechanism by serum pharmacology and toxicokinetics, the comprehensive evaluation on toxicity based on quantitative theory.

  13. [Principles for molecular identification of traditional Chinese materia medica using DNA barcoding].

    Science.gov (United States)

    Chen, Shi-Lin; Yao, Hui; Han, Jian-Ping; Xin, Tian-Yi; Pang, Xiao-Hui; Shi, Lin-Chun; Luo, Kun; Song, Jing-Yuan; Hou, Dian-Yun; Shi, Shang-Mei; Qian, Zhong-Zhi

    2013-01-01

    Since the research of molecular identification of Chinese Materia Medica (CMM) using DNA barcode is rapidly developing and popularizing, the principle of this method is approved to be listed in the Supplement of the Pharmacopoeia of the People's Republic of China. Based on the study on comprehensive samples, the DNA barcoding systems have been established to identify CMM, i.e. ITS2 as a core barcode and psbA-trnH as a complementary locus for identification of planta medica, and COI as a core barcode and ITS2 as a complementary locus for identification of animal medica. This article introduced the principle of molecular identification of CMM using DNA barcoding and its drafting instructions. Furthermore, its application perspective was discussed.

  14. [Status and future of natural resource for Chinese materia medica].

    Science.gov (United States)

    Ma, Xiao-jing; Guo, Juan; Tang, Jin-fu; Ma, Xiao-hui; Ma, Ying; Dai, Zhu-bo; Guo, Lan-ping; Huang, Lu-qi

    2015-05-01

    For thousands of years, the natural resource for Chinese materiamedica has been the foundation of the traditional Chinese medicine industry, which provides abundant medicine for human. In recent years, increasing demands and irrational exploitation led to a lot of problems such as rapid decrease of traditional Chinese herbs reserves, low quality of medicine and dismishing traditional cultures. These restricted the development of the traditional Chinese medicine. To solve these problems, scientists have done much work on investigating traditional Chinese medicine resources, exploring the metabolic pathway of bioactive ingredients, cultivating new varieties, and carrying out synthetic biology. These studies provided a theoretical basis for sustainable utilizationand future developmentof traditional Chinese medicine resources.

  15. Feature Extraction of Chinese Materia Medica Fingerprint Based on Star Plot Representation of Multivariate Data

    Institute of Scientific and Technical Information of China (English)

    CUI Jian-xin; HONG Wen-xue; ZHOU Rong-juan; GAO Hai-bo

    2011-01-01

    Objective To study a novel feature extraction method of Chinese materia medica (CMM) fingerprint. Methods On the basis of the radar graphical presentation theory of multivariate, the radar map was used to figure the non-map parameters of the CMM fingerprint, then to extract the map features and to propose the feature fusion. Results Better performance was achieved when using this method to test data. Conclusion This shows that the feature extraction based on radar chart presentation can mine the valuable features that facilitate the identification of Chinese medicine.

  16. Traditional Chinese materia medica: a retrospect and prospect

    Directory of Open Access Journals (Sweden)

    Dong-Lu Bay

    1991-01-01

    Full Text Available For thousands of years, traditional medicine and remedies have been practed and used in the fight against disease in China. They have proved to be valuable and the distillate of vast historical experience based on field-tested human experiments, long-term observations and clinical trials. The Chinese people belive that traditional medicine is consistent with theirown culture. Endowed with a unique theoretical system and provided outstanding clinical results, traditional Chinese medicine continues to play an important role in helping the Chinese nation flourish. The recent study of traditional medicinal plants in Chine has given us confidence that what was recorded in ancient medical literature through empirical observations is indeed still coindicent with the concepts of modern chemistry, pharmacology and medicine. The task of revealing what is valid and efficacious should be retained, and what is mythic and invalid should be discarded in traditional Chinese medicine may require scientific research lasting for several generations. Therfore, multidisciplinary cooperation and international collaboration in this field would be essential. Systematic coordination of work in traditional medicine by word organizations, national governments, private foundations and individual scientists is a requisite as well.

  17. A unique issue in the standardization of Chinese materia medica: processing.

    Science.gov (United States)

    Zhao, Zhongzhen; Liang, Zhitao; Chan, Kelvin; Lu, Guanghua; Lee, Eko Lai Mei; Chen, Hubiao; Li, Lin

    2010-12-01

    Processing of Chinese Materia Medica (CMM) is a pharmaceutical technique to fulfill the different requirements of therapy, dispensing and making preparations according to traditional Chinese medicine theory. The aims of processing are to enhance the efficacy and/or reduce the toxicity of crude drugs. Those processed products are named as decoction pieces, which are used in clinics. Therefore, there is a close relationship between processing, safety, and efficacy of Chinese medicines. Some toxicity or side effects are caused by improper processing methods and some are due to improper combination of herbal mixtures. Standardization of processing methods for Chinese herbs is as important as authentication to maintain their quality and ensure their safe use. The objective of this paper is to review the literature covering the current situation and problems of CMM processing as well as recent progress in research in this area. A summary of the most urgent work needed is proposed.

  18. Authentication of Chinese Materia Medica decoction dregs. Part II: comparison before and after decoction of four Chinese Materia Medica that mainly comprise storage tissue.

    Science.gov (United States)

    Wong, Lailai; Liang, Zhitao; Chen, Hubiao; Zhao, Zhongzhen

    2012-02-01

    Authentication of Chinese Materia Medica (CMM) decoction dregs is important for ensuring the efficacy and safety of CMM when they are used in decoction. If someone got worse or poisoned after taking a decoction while the formula is appropriate, the authentication of CMM dregs is the effective method to explore the reasons. Therefore, a systematic study on the authentication of CMM dregs was carried out. In this study, two pairs of easily confused CMM dregs, Fenge (Puerariae Thomsonii Radix) and Shanyao (Dioscoreae Rhizoma), Dihuang (Rehmanniae Radix) and Huangjing (Polygonati Rhizoma), which mostly comprise storage tissues, were investigated by comparing the morphological and microscopic characteristics. Fenge and Shanyao contain abundant starch granules. After decoction their dregs were hard, nonstarchy and horn-like. Fully gelatinized starch granules were found in the powder of Fenge dregs while incompletely gelatinized starch granules were occasionally found in the Shanyao dregs. In contrast, Dihuang and Huangjing contain water-soluble sugars. After decoction, their dregs were hard and brittle. Their parenchymatous cells were shrunken and unknown crystals were found under microscope. Hence, the morphological and microscopic characteristics of CMM before and after decoction were different, and different changes in the CMM dregs can be illustrated by the different nature of their ergastic substance. These differences could be used to authenticate CMM dregs.

  19. [Key content and formulation of national Chinese materia medica resources survey at county level].

    Science.gov (United States)

    Lu, Jian-Wei; Zhang, Xiao-Bo; Li, Hai-Tao; Guo, Lan-Ping; Zhao, Run-Huai; Zhang, Ben-Gang; Sun, Li-Ying; Huang, Lu-Qi

    2013-08-01

    According to National Census for Water, National Population Census, National Land and Resources Survey, and work experience of experimental measures for national Chinese materia medica resources(CMMR) survey,the national CMMR survey at the county level is the key point of whole survey, that includes organization and management, field survey, sorting data three key links. Organization and management works of national CMMR survey needs to finish four key contents, there are definite goals and tasks, practicable crew, preparation directory, and security assurance. Field survey works of the national CMMR survey needs to finish five key contents, there are preparation works for field survey, the choice of the key survey area (samples), fill in the questionnaire, video data collection, specimen and other physical collection. Sorting data works of the national CMMR survey needs to finish tree key contents, there are data, specimen and census results.

  20. PAT: From Western solid dosage forms to Chinese materia medica preparations using NIR-CI.

    Science.gov (United States)

    Zhou, Luwei; Xu, Manfei; Wu, Zhisheng; Shi, Xinyuan; Qiao, Yanjiang

    2016-01-01

    Near-infrared chemical imaging (NIR-CI) is an emerging technology that combines traditional near-infrared spectroscopy with chemical imaging. Therefore, NIR-CI can extract spectral information from pharmaceutical products and simultaneously visualize the spatial distribution of chemical components. The rapid and non-destructive features of NIR-CI make it an attractive process analytical technology (PAT) for identifying and monitoring critical control parameters during the pharmaceutical manufacturing process. This review mainly focuses on the pharmaceutical applications of NIR-CI in each unit operation during the manufacturing processes, from the Western solid dosage forms to the Chinese materia medica preparations. Finally, future applications of chemical imaging in the pharmaceutical industry are discussed.

  1. [Impacts of multicomponent environment on solubility of puerarin in biopharmaceutics classification system of Chinese materia medica].

    Science.gov (United States)

    Hou, Cheng-Bo; Wang, Guo-Peng; Zhang, Qiang; Yang, Wen-Ning; Lv, Bei-Ran; Wei, Li; Dong, Ling

    2014-12-01

    To illustrate the solubility involved in biopharmaceutics classification system of Chinese materia medica (CMMBCS) , the influences of artificial multicomponent environment on solubility were investigated in this study. Mathematical model was built to describe the variation trend of their influence on the solubility of puerarin. Carried out with progressive levels, single component environment: baicalin, berberine and glycyrrhizic acid; double-component environment: baicalin and glycyrrhizic acid, baicalin and berberine and glycyrrhizic acid and berberine; and treble-component environment: baicalin, berberin, glycyrrhizic acid were used to describe the variation tendency of their influences on the solubility of puerarin, respectively. And then, the mathematical regression equation model was established to characterize the solubility of puerarin under multicomponent environment.

  2. [Formulation of technical specification for national survey of Chinese materia medica resources].

    Science.gov (United States)

    Guo, Lan-Ping; Lu, Jian-Wei; Zhang, Xiao-Bo; Zhao, Run-Huai; Zhang, Ben-Gang; Sun, Li-Ying; Huang, Lu-Qi

    2013-04-01

    According to the process of the technical specification (TS) design for the fourth national survey of the Chinese materia medica resources (CMMR), we analyzed the assignment and objectives of the national survey and pointed out that the differences about CMMR management around China, the distribution of CMMR and their habitat, the economic and technological level, and even enthusiasm and initiative of the staff, etc. are the most difficult points for TS design. And we adopt the principle of combination of the mandatory and flexibility in TS design. We fixed the key points which would affect the quality of national survey first, then proposed the framework of TS which including 3 parts of organization and 11 parts of technique itself. The framework will serve and lead the TS preparation, which will not only provide an action standard to the national survey but will also have a profound influence to the popularization and application of the survey technology of CMMR. [Key words

  3. [Real-time detection of quality of Chinese materia medica: strategy of NIR model evaluation].

    Science.gov (United States)

    Wu, Zhi-sheng; Shi, Xin-yuan; Xu, Bing; Dai, Xing-xing; Qiao, Yan-jiang

    2015-07-01

    The definition of critical quality attributes of Chinese materia medica ( CMM) was put forward based on the top-level design concept. Nowadays, coupled with the development of rapid analytical science, rapid assessment of critical quality attributes of CMM was firstly carried out, which was the secondary discipline branch of CMM. Taking near infrared (NIR) spectroscopy as an example, which is a rapid analytical technology in pharmaceutical process over the past decade, systematic review is the chemometric parameters in NIR model evaluation. According to the characteristics of complexity of CMM and trace components analysis, a multi-source information fusion strategy of NIR model was developed for assessment of critical quality attributes of CMM. The strategy has provided guideline for NIR reliable analysis in critical quality attributes of CMM.

  4. [Investigation on pattern of quality control for Chinese materia medica based on famous-region drug and bioassay--the work reference].

    Science.gov (United States)

    Yan, Dan; Xiao, Xiaohe

    2011-05-01

    Selection and standardization of the work reference are the technical issues to be faced with in the bioassay of Chinese materia medica. Taking the bioassay of Coptis chinensis. as an example, the manufacture process of the famous-region drugs extraction was explained from the aspects of original identification, routine examination, component analysis and bioassay. The common technologies were extracted, and the selection and standardization procedures of the work reference for the bioassay of Chinese materia medica were drawn up, so as to provide technical support for constructing a new mode and method of the quality control of Chinese materia medica based on the famous-region drugs and bioassay.

  5. Research and Development of New Chinese Materia Medica for Treatment of Refractory Hematopathy by Establishment and Application of Multiple Technique Platforms

    Institute of Scientific and Technical Information of China (English)

    GAO Rui-lan

    2007-01-01

    @@ Research Objective andOverview It is necessary to find effective Chinese materia medica (CMM)for the treatment of refractory hematopathy as commonly used prednisone, androgen and immune suppression agents often demonstrate poor efficacy and serious side effects.

  6. Advances and challenges in screening traditional Chinese anti-aging materia medica.

    Science.gov (United States)

    Li, Chun-Sheng; Deng, Hong-Bin; Li, Dian-Dong; Li, Zhao-He

    2013-04-01

    To provide a better service for senior health care, we summarized screening studies of traditional Chinese anti-aging materia medica (TCAM). We collected and analyzed literature of TCAM screening studies using the lifespan test and animal models of aging from 1984 to 2012. We found 26 screening methods for TCAM, and 153 single herbs or active ingredients of TCAM that have been screened out during the past 28 years. The cell lifespan test, the fruit fly lifespan test, and D-galactose aging model were the most widely used and intensively studied screening methods. However, the method for establishing the D-galactose aging model needs to be standardized, and the D-galactose aging model cannot completely be a substitute for the normal aging mouse model. Great success has been achieved in screening studies in TCAM. To further improve screening studies in TCAM, we suggest that the D-galactose aging model be incorporated into the lifespan test in the New Drugs of Traditional Chinese Medicine Research Guide.

  7. [Applications and approved projectsof general program, young scientist fund and fund for less developedregion of national natural science funds in discipline of Chinese materia medica, NSFC in 2012].

    Science.gov (United States)

    Huang, Ming-Qing; Han, Li-Wei; Wu, Xiu-Hong; Bi, Ming-Gang; Shang, Hong-Cai; Liu, Yun-Fang; He, Wei-Ming; Li, Dan-Dan; Dong, Yan; Wang, Chang-En

    2013-01-01

    The applications accepted and approved by general program, young scientist fund and fund for less developed region of national natural science funds in the discipline of Chinese materia medica, NSFC in 2012 have been introduced. The research contents of the funded projects in the popular research areas have been summarized and the problems in the applications have been analyzed to give a reference to the scientists in the field of Chinese materia medica.

  8. What has been overlooked on study of Chinese materia medica in the West?

    Science.gov (United States)

    Liu, Willow J H

    2015-07-01

    Chinese materia medica (CMM), including Chinese herbal, animal, and mineral medicine, has been widely researched in the past century for their biological and pharmacological activities. However, their mechanism and clinical efficacy studies did not always give expected results. For example, the most commonly used Chinese herb for menstrual disorders, Radix Angelicae sinensis, showed neither estrogenic nor progesteronic activity in laboratory and clinical studies. Its efficacy should not be denied simply based on such results, because it is mostly used together with other herbs in formulae. Moreover, its regulation on menstruation may take effect through other mechanisms, such as regulation of blood circulation. The key difference of Chinese medicine (CM) from conventional medicine is its unique holistic view on human body and diseases. CMM is mostly applied in clinic in the form of formulae. Study on individual CMM, simply using methods for development of conventional drugs, is unable to thoroughly reveal the power of CMM formulae. The reason may partly result from improper design due to the lack understanding about application principle of CMMs in CM, and/or to current lack of knowledge about the causes of some symptoms and diseases. This paper will introduce the importance of qi and blood in CM etiology and pathology, Zheng differentiation, formulation of CMMs, and explain why one formula can treat different diseases and one disease can be treated with different formulae. Examples in the paper will demonstrate that proper studies on Zheng and its corresponding clinically proven formulae could help scientists find new direction to explain and treat symptoms and diseases that so far modern medicine has been unable to, provided that the designer properly understands CM theories, etiology and pathology of CM, as well as modern medicine. Strategy suggestions about research methods for CMM and its formulae will be given at the end.

  9. [Rapid assessment of critical quality attributes of Chinese materia medica (II): strategy of NIR assignment].

    Science.gov (United States)

    Pei, Yan-Ling; Wu, Zhi-Sheng; Shi, Xin-Yuan; Zhou, Lu-Wei; Qiao, Yan-Jiang

    2014-09-01

    The present paper firstly reviewed the research progress and main methods of NIR spectral assignment coupled with our research results. Principal component analysis was focused on characteristic signal extraction to reflect spectral differences. Partial least squares method was concerned with variable selection to discover characteristic absorption band. Two-dimensional correlation spectroscopy was mainly adopted for spectral assignment. Autocorrelation peaks were obtained from spectral changes, which were disturbed by external factors, such as concentration, temperature and pressure. Density functional theory was used to calculate energy from substance structure to establish the relationship between molecular energy and spectra change. Based on the above reviewed method, taking a NIR spectral assignment of chlorogenic acid as example, a reliable spectral assignment for critical quality attributes of Chinese materia medica (CMM) was established using deuterium technology and spectral variable selection. The result demonstrated the assignment consistency according to spectral features of different concentrations of chlorogenic acid and variable selection region of online NIR model in extract process. Although spectral assignment was initial using an active pharmaceutical ingredient, it is meaningful to look forward to the futurity of the complex components in CMM. Therefore, it provided methodology for NIR spectral assignment of critical quality attributes in CMM.

  10. Effects of Chinese Materia Medica-Fubao Danggui Jiao on experimental endometriosis.

    Science.gov (United States)

    Sun, Xing; Chen, Lijue; Zeng, Fanbo

    2011-01-01

    The objective of this paper was to investigate the effects of a Chinese Materia Medica variant -Fubao Danggui Jiao (FDJ)-on experimental endometriosis. An endometriosis model was created by virtue of auto-transplantation of endometrial tissue onto rats' abdominal walls. The implants were allowed to grow for 30 days until the successful completion of the model. After that, forty endometriotic rats were randomly divided into four study groups and given different treatments: (1) negative control group (water, 2ml/kg, per os); (2) FDJ-A group (FDJ, 2ml/kg, per os); (3) FDJ-B group (FDJ, 4ml/kg, per os); (4) Danazol group (70mg/kg, per os). After 30 days with treatments, the volumes of endometriotic implants in each rat were measured. The implants and normal uterine horns were removed for routine histological examination. FDJ caused significant decreases in volumes of the surviving endometriotic implants, with two different doses having statistically equivalent effects. Upon histological examination, FDJ was observed to cause regression of epithelium and stroma of endometriotic implants. FDJ had revealed promising therapeutic effects on endometriosis.

  11. [Research on Zhang's collated edition of Lei gong pao zhi lun (Master Lei's Discourse on Processing of Chinese Materia Medica)].

    Science.gov (United States)

    Cheng, Li

    2010-05-01

    Lei gong pao zhi lun (Master Lei's Discourse on Processing of Chinese Materia Medica) collated by Zhang Ji, and printed by Zhang's Yisheng Tang in Chengdu in 1932 was the first collated edition. Its original edition was not Jing shi zheng lei bei ji ben cao (Classified Materia Medica from Historical Classics for Emergency) of the Song Dynasty, but was Xiu shi zhi nan (Instruction for Drug Processing) and Lei gong pao zhi yao xing jie (Explanation on Master Lei's Properties of Drugs Processing) of the Qing Dynasty. The contents of this collated edition was far from Lei gong pao zhi lun with many mistakes, and was not the best edition to study Lei gong pao zhi lun.

  12. [The significance of drawing on experience of experimental study on Chinese materia medica during the Republican period].

    Science.gov (United States)

    Li, Nan; Wan, Fang

    2015-05-01

    During the period of the Republic of China, researches of experiments on Chinese materia medica developed extensively with the scientific process of Chinese medicine. Although the technology standard was relatively low and the reference value, limited. The experiences, positive or negative, obtained at that time still has reference significance to today's Chinese medicine scientific research. The notion that traditional Chinese medical and scientific research be conducted under the guidance of TCM theory; valuable experience contained in the ancient literature of traditional Chinese medicine be collected; and the transformation capacity of scientific research be elevated, has been accepted by modern TCM professionals. If you go back to the history, it can be seen that this notion was summarized through repeated practice during the critical moment of traditional Chinese medicine, which should be emphasized and its understanding deepened at any time.

  13. [Good agricultural practice (GAP) of Chinese materia medica (CMM) for ten years: achievements, problems and proposals].

    Science.gov (United States)

    Guo, Lan-Ping; Zhang, Yan; Zhu, Shou-Dong; Wang, Gui-Hua; Wang, Xiu; Zhang, Xiao-Bo; Chen, Mei-Lan; He, Ya-Li; Han, Bang-Xing; Chen, Nai-Fu; Huang, Lu-Qi

    2014-04-01

    This paper aims to summarize the achievements during the implementation process of good agricultural practice (GAP) in Chinese Materia Medica (CMM), and on basis of analyzing the existing problems of GAP, to propose further implementation of GAP in TCM growing. Since the launch of GAP in CMM growing ten years ago, it has acquired great achievements, including: (1) The promulgation of a series of measures for the administration of the GAP approval in the CMM growing; (2) The expanded planting area of CMM; (3) The increased awareness of standardized CMM growing among farmers and enterprises; (4) The establishment of GAP implementation bases for CMM growing; (5) The improvement of theory and methodology for CMM growing; (6) The development of a large group of experts and scholars in GAP approval for CMM production. The problems existing in the production include: (1) A deep understanding of GAP and its certification is still needed; (2) The distribution of the certification base is not reasonable; (3) The geo-economics effect and the backward farming practices are thought to be the bottlenecks in the standardization of CMM growing and the scale production of CMM; (4) Low comparative effectiveness limits the development of the GAP; (5) The base of breeding improved variety is blank; (6) The immature of the cultivation technique lead to the risk of production process; (7) The degradation of soil microbial and the continuous cropping obstacle restrict the sustainable development of the GAP base. To further promote the health and orderly GAP in the CMM growing, the authors propose: (1) To change the mode of production; (2) To establish a sound standard system so as to ensure quality products for fair prices; (3) To fully consider the geo-economic culture and vigorously promote the definite cultivating of traditional Chinese medicinal materials; (4) To strengthen the transformation and generalization of basic researches and achievements, in order to provide technical

  14. [Analysis of projects funded by NSFC in field of processing Chinese materia medica in recent five years].

    Science.gov (United States)

    Chen, Lei; Xia, Xing; He, Bo-sai; Hah, Li-wei

    2015-05-01

    The general situation of the approved and concluded projects of National Natural Science Foundation of China in the field of processing Chinese Materia Medica in recent five years has been reviewed. The progresses and achievements of some projects have been summarized in accordance with research area such as the processing principle, the processing technology, quality evaluation, toxicity and safety evaluation, etc. The researchers and project support units of the funded projects have been analyzed, and the problems of the applications have been also summarized.

  15. [Study on supply and demand relation based on two stages division of market of Chinese materia medica].

    Science.gov (United States)

    Yang, Guang; Guo, Lan-Ping; Wang, Nuo; Zeng, Yan; Huang, Lu-Qi

    2014-01-01

    The complex production processes and long industrial chain in traditional Chinese medicine (TCM) market result in difficulty in Chinese market microstructure research. Based on the defining the logical relationships among different concepts. This paper divides TCM market into two stages as Chinese materia medica resource market and traditional Chinese Patent Medicines market. Under this foundation, we investigated the supply capacity, approaching rules and motivation system of suppliers in TCM market, analyzed the demand situation in the perspective of demand side, and evaluated the purchasing power in terms of population profile, income, and insurance. Furthermore we also analyzed the price formation mechanism in two stages of TCM market. We hope this study can make a positive and promotion effect on TCM market related research.

  16. 中药DNA条形码鉴定体系及研究方向%Identification System and Perspective for DNA Barcoding Traditional Chinese Materia Medica

    Institute of Scientific and Technical Information of China (English)

    陈士林; 庞晓慧; 姚辉; 韩建萍; 罗焜

    2011-01-01

    近年来,中药DNA条形码分子鉴定得到快速发展,加快了中药鉴定标准化的进程.通过中药DNA条形码鉴定研究,我国首次提出将ITS2序列作为药用植物鉴定的通用条形码序列,并建立以ITS2为核心、psbA -trnH为补充序列的植物类药材DNA条形码鉴定体系和以COI序列为核心、ITS2为辅助序列的动物类药材DNA条形码鉴定体系,为中药DNA条形码鉴定的发展奠定了坚实基础.本文结合课题组研究工作就构建中药DNA条形码鉴定体系进行了综述,包括中药DNA条形码序列的筛选确定、中药DNA条形码鉴定流程和中药DNA条形码鉴定数据库系统构建,并介绍了中药DNA条形码鉴定的研究方向.%DNA barcoding in Traditional Chinese Materia Medica has developed rapidly in recent years, which accelerates the progress of standardization in identifying Traditional Chinese Materia Medica. Chen et al. First proposed that ITS2 locus can be used as the standard barcode for identifying medicinal plant species based on an extensive study on DNA barcoding in Traditional Chinese Materia Medica. Meanwhile, the systems for barcoding medicinal plants based on a two-locus combination of ITS2+psbA-trnH and for authenticating medicinal animals based on COI+ITS2 have been established, providing a basis for the development of DNA barcoding in Traditional Chinese Materia Medica. In this review, we summarize the establishment of the system for barcoding Traditional Chinese Materia Medica, including the selection and determination of DNA barcodes, the identification process of DNA barcoding in Traditional Chinese Materia Medica and building the database system of DNA barcoding in Traditional Chinese Materia Medica. Moreover, we describe the perspective for further research on DNA barcoding in Traditional Chinese Materia Medica.

  17. [Investigation on pattern and methods of quality control for Chinese materia medica based on dao-di herbs and bioassay - bioassay for Coptis chinensis].

    Science.gov (United States)

    Yan, Dan; Xiao, Xiao-he

    2011-05-01

    Establishment of bioassay methods is the technical issues to be faced with in the bioassay of Chinese materia medica. Taking the bioassay of Coptis chinensis Franch. as an example, the establishment process and application of the bioassay methods (including bio-potency and bio-activity fingerprint) were explained from the aspects of methodology, principle of selection, experimental design, method confirmation and data analysis. The common technologies were extracted and formed with the above aspects, so as to provide technical support for constructing pattern and method of the quality control for Chinese materia medica based on the dao-di herbs and bioassay.

  18. [Effect of multicomponent environment on intestinal permeability of puerarin in biopharmaceutics classification system of Chinese materia medica].

    Science.gov (United States)

    Liu, Yang; Wang, Gang; Dong, Ling; Tang, Ming-Min; Zhu, Mei-Ling; Dong, Hong-Huant; Hou, Cheng-Bo

    2014-12-01

    The evaluation of permeability in biopharmaceutics classification system of Chinese materia medica (CMMBCS) requires multicomponent as a whole in order to conduct research, even in the study of a specific component, should also be put in the multicomponent environment. Based on this principle, the high content components in Gegen Qinlian decoction were used as multicomponent environmental impact factors in the experiment, and the relevant parameters of intestinal permeability about puerarin were measured with using in situ single-pass intestinal perfusion model, to investigate and evaluate the intestinal permeability of puerarin with other high content components. The experimental results showed that different proportions of baicalin, glycyrrhizic acid and berberine had certain influence on intestinal permeability of puerarin, and glycyrrhizic acid could significantly inhibit the intestinal absorption of puerarin, moreover, high concentration of berberine could promote the absorption of puerarin. The research results indicated that the important research ideas of permeability evaluation in biopharmaceutics classification system of Chinese materia medica with fully considering the effects of other ingredients in multicomponent environment.

  19. [Inheritance on and innovation of traditional Chinese medicine (TCM) flavor theory and TCM flavor standardization principle flavor theory in Compendium of Materia Medica].

    Science.gov (United States)

    Zhang, Wei; Zhang, Rui-xian; Li, Jian

    2015-12-01

    All previous literatures about Chinese herbal medicines show distinctive traditional Chinese medicine (TCM) flavors. Compendium of Materia Medica is an influential book in TCM history. The TCM flavor theory and flavor standardization principle in this book has important significance for modern TCM flavor standardization. Compendium of Materia Medica pays attention to the flavor theory, explain the relations between the flavor of medicine and its therapeutic effects by means of Neo-Confucianism of the Song and Ming Dynasties. However,the book has not reflected and further developed the systemic theory, which originated in the Jin and Yuan dynasty. In Compendium of Materia Medica , flavor are standardized just by tasting medicines, instead of deducing flavors. Therefore, medicine tasting should be adopted as the major method to standardize the flavor of medicine.

  20. Chinese Marine Materia Medica. By Huashi Guan and Shuguang Wang. Shanghai Scientific and Technical Publishers, China Ocean Press, and Chemical Industry Press: Shanghai, Beijing, China, 2009; Hardback, 7064 pp; ¥ 2920; ISBN 978-7-5323-9958-1/R•2707; ISBN 978-7-5323-9973-4/R•2708; ISBN 978-7-1220-6012-9

    OpenAIRE

    Peter Proksch

    2014-01-01

    China is one of the first countries to use marine materia medica for treating diseases. Ancient books on Chinese herbology, such as Shennong Bencaojing (Shennong’s Classic of Materia Medica), Xinxiu Bencao (Newly Revised Materia Medica) and Bencao Gangmu (Compendium of Materia Medica), have detailed more than 110 marine herbs and thousands of marine herbal formulas (including those for Chinese food therapy). A great deal of information on marine herbs and their applications in medicine, colle...

  1. [Applications and spproved projects of general program, young scientist fund and fund for less developed region of national natural science funds in discipline of Chinese materia medica, NSFC in 2011].

    Science.gov (United States)

    Han, Liwei; Wang, Yueyun; He, Wenbin; Zhang, Junjie; Bi, Minggang; Shang, Hongcai; Shang, Deyang; Wang, Chang'en

    2012-03-01

    The applications accepted and approved by general program, young scientist fund and fund for less developed region of national natural science funds in the discipline of Chinese materia medica, NSFC in 2011 have been introduced. The character and problems in these applications have been analyzed to give a reference to the scientists in the field of Chinese material medica.

  2. 疼痛的中药药理研究概况%Reviews of Pharmacological Studies on Chinese Materia Medica of Pain

    Institute of Scientific and Technical Information of China (English)

    王晔; 王丹巧

    2013-01-01

      目的整理与总结有关疼痛的中药药理研究概况与进展。方法查阅中医古典医籍及近二十年来有关疼痛的中药药理研究文献,进行整理和总结。结果通过对相关文献的查阅与总结,认识中药药理研究在疼痛领域所取得的进展及其中存在的问题。结论对疼痛的认识与治疗水平随着中药药理研究的深入不断提高,但受科学发展水平和研究者认知水平的局限,仍存在一些问题亟待解决。%Objective To summarize the pharmacological studies and advances on Chinese materia medica of pain. Method Check and summarize traditional Chinese medical classics and literatures of pharmacological studies on Chinese materia medica of pain during the last twenty years. Result Both progress and problems exist in the field of pharmacological studies on Chinese materia medica of pain. Conclusion With the progress of pharmacological studies on Chinese materia medica of pain, the understanding and the treatment of pain is improving, while because of the limit of scientific development level at that time or the understanding level of researchers, some problems still remain to be solved.

  3. [A glance at the property of acupoints--analysis on functions of acupoints in view of actions of Chinese materia medica].

    Science.gov (United States)

    Wang, Jun; Zhao, Ji-ping

    2008-08-01

    The acupoint is one of the basic elements of the acupuncture prescription. Just as thinking over different properties of every Chinese materia medica in a prescription, we should also sufficiently consider the characteristics of each acupoint in a prescription of acupuncture or moxibustion. Chinese materia medica have their own action-tendencies of lifting, lowering, floating and sinking, properties of cold, hot, warm and cool, five flavors of sour, bitter, sweet, acrid and salty, target-meridian distribution, different toxicity and actions, etc. What are the properties of acupoints? The authors of the present paper summarize them by simulating the characters of Chinese materia medica. It is found that acupoints also have functions in regulating lifting, lowering, floating and sinking of Qi, inducing cold and heat effects, producing different needling sensations; and pertain to different meridians (meridian distribution). And acupoint stimulation may produce adverse effects under certain specific conditions, etc. Full understanding of the properties of acupoints is definitely helpful in improving clinical therapeutic effects and shortening therapeutic courses by reasonably selecting and combining related acupoints.

  4. [Applications and prospects of on-line near infrared spectroscopy technology in manufacturing of Chinese materia medica].

    Science.gov (United States)

    Li, Yang; Wu, Zhi-Sheng; Pan, Xiao-Ning; Shi, Xin-Yuan; Guo, Ming-Ye; Xu, Bing; Qiao, Yan-Jiang

    2014-10-01

    The quality of Chinese materia medica (CMM) is affected by every process in CMM manufacturing. According to multi-unit complex features in the production of CMM, on-line near infrared spectroscopy (NIR) is used as an evaluating technology with its rapid, non-destructive and non-pollution etc. advantages. With the research in institutions, the on-line NIR applied in process analysis and control of CMM was described systematically, and the on-line NIR platform building was used as an example to clarify the feasibility of on-line NIR technology in CMM manufacturing process. Then, from the point of application by pharmaceutical companies, the current on-line NIR research on CMM and its production in pharmaceutical companies was relatively comprehensively summarized. Meanwhile, the types of CMM productions were classified in accordance with two formulations (liquid and solid dosage formulations). The different production processes (extraction, concentration and alcohol precipitation, etc. ) were used as liquid formulation diacritical points; the different types (tablets, capsules and plasters, etc.) were used as solid dosage formulation diacritical points, and the reliability of on-line NIR used in the whole process in CMM production was proved in according to the summary of literatures in recent 10 years, which could support the modernization of CMM production.

  5. 临床导向的创新中药研究%Clinically-oriented Innovation of Chinese Materia Medica

    Institute of Scientific and Technical Information of China (English)

    肖红斌; 刘丹; 刘艳秋; 张良晓

    2013-01-01

    It is a key task in traditional Chinese medicine (TCM) modernization and internationalization to develop Chinese Materia Medica (CMM) with the clear component, interaction mechanism and controllable quality based on the inheritance of TCM theories and characteristics of systematic regulation & individual treatment according to TCM syndrome. With the upsurge of translational medicine, the novel methods of metabonomics and other-omics will be married with the plentiful TCM clinical experiences according to the regulation of translational medicine, i. e., from the clinical trial to laboratory research and back to clinical therapies for patients. Undoubtedly, this research mode of translational medicine will provide fresh inspiration for inheritance and development of traditional Chinese medicine.%继承传统中医药理论和中药整体调理、辨证施治治疗特色,发展成分明确、机理清楚、质量可控的创新中药是中药现代化的主要任务.在当前转化医学提出的国际化背景下,发挥传统中药丰富临床经验的优势,结合现代“组学”等整体研究的思路,探寻临床观察-实验验证-临床检验的转化医学研究模式,将为传统中药的继承和发展提供新思路,为创新中药的开发提供新方法.

  6. An improved association-mining research for exploring Chinese herbal property theory: based on data of the Shennong's Classic of Materia Medica.

    Science.gov (United States)

    Jin, Rui; Lin, Zhi-jian; Xue, Chun-miao; Zhang, Bing

    2013-09-01

    Knowledge Discovery in Databases is gaining attention and raising new hopes for traditional Chinese medicine (TCM) researchers. It is a useful tool in understanding and deciphering TCM theories. Aiming for a better understanding of Chinese herbal property theory (CHPT), this paper performed an improved association rule learning to analyze semistructured text in the book entitled Shennong's Classic of Materia Medica. The text was firstly annotated and transformed to well-structured multidimensional data. Subsequently, an Apriori algorithm was employed for producing association rules after the sensitivity analysis of parameters. From the confirmed 120 resulting rules that described the intrinsic relationships between herbal property (qi, flavor and their combinations) and herbal efficacy, two novel fundamental principles underlying CHPT were acquired and further elucidated: (1) the many-to-one mapping of herbal efficacy to herbal property; (2) the nonrandom overlap between the related efficacy of qi and flavor. This work provided an innovative knowledge about CHPT, which would be helpful for its modern research.

  7. Practice and thought of MOOC for Chinese materia medica%中药学MOOC课程的制作实践与思考

    Institute of Scientific and Technical Information of China (English)

    刘四军; 刘步平; 吴庆光

    2015-01-01

    目的:大规模开放在线课程(Massive Open Online Course,MOOC)近年来受到国际教育界的高度关注,对高等教育正在产生着广泛而深远的影响。以传统医学的基础学科中药学作为切入点,对中药学MOOC制作进行实践与探索。方法通过中药学授课老师团队的研讨,在对整个中药学知识点进行梳理、模块化、单元化的基础上,组建MOOC拍摄团队,对课程进行视频制作、发表、互动以及管理,并总结了制作过程中遇到的问题。结果在团队合作的基础上,开发了中药学MOOC课程,从而改进互动方式和课程,使教学更有效。结论MOOC可能是未来教育资源建设的聚焦点,制作优质的MOOC资源是首当其冲的问题。%Objective Massive open online course (MOOC) has received close attention in the international educational world in recent years, and has brought about wide and far-reaching influence on higher education. This paper explored and practiced production of MOOC by taking Chinese materia medica as an entry point. Methods Research was conducted by Chinese materia medica teaching team to find out knowledge points for teaching in different modules and units. Shooting team was also organized for video producing, issuing, interaction and management. Problems in the course of production were summarized. Results Online course of Chinese materia medica might contribute to interactive mode of teaching and result in more effective teaching. Conclusion MOOC can be the focus of the future construction of educational resources. Production of high-quality MOOC resources is the most important issue to be considered.

  8. [Revision to origin of northern Artemisia argyi in Compendium of Materia Medica (Bencao gangmu)].

    Science.gov (United States)

    Huang, Lu-qi; Qiu, Le

    2014-12-01

    The origin of northern Artemisia argyi recorded in Compendium of Materia Medica(Bencao gangmu) is Fudao(Chinese characters) in Tangyin county, While there is only Fudao(Chinese characters) instead of Fudao(Chinese characters). Whether indeed Fudao(Chinese characters) is Fudao(Chinese characters)? By reviewing the genuine evolution of A. argyi, doing textual research on Fudao(Chinese characters) and combing with field survey data of national census of Chinese Materia Medica resources, this paper concluded that the word Fudao(Chinese characters) firstly emerged in Figure Canon of Chinese Materia Medica(Bencao tujing) of Susong in Song dynasty and was applied in later generations, but the implication was not clear, then emerged both Tangyin and Fudao(Chinese characters) in Compendium of Materia Medica(Bencao gangmu). The place Fudao(Chinese characters) is one of the graves of Bianque, that existed from Shang and Zhou dynasty and never changed until now, the A. argyi of Tangyin was famous from the grave of Bianque in Fudao(Chinese characters), which could infer that Lishizhen considered Fudao (Chinese characters) was Fudao(Chinese characters) indeed, and the origin of northern A. argyi was Fudao(Chinese characters) in Tangyin county.

  9. [Influence of compendium of Materia Medica on the materia medica in the late period of the Chosun Dynasty].

    Science.gov (United States)

    Oh, Chae-Kun

    2012-08-31

    In this paper, I investigated the influence of Compendium of Materia Medica (CM) on Records for Rural Life of Chosun Gentlemen (RRC), and refuted Miki Sakae's opinion, CM did not have much impact on the Materia Medica in the late period of the Chosun Dynasty. When Li Shizhen published CM, it resulted in a shift of mainstream of Materia Medica in Eastern Asia from Classified Emergency Materia Medica to CM and a new categorizing system of Materia Medica by CM led to the division of Materia Medica into medicine and natural history. It is obvious that doctors of the Chosun Dynasty also adopted the latest achievements of Materia Medica by CM, but so far there have been few studies to clarify this. Seo yugu was a scholar of the Realist School of Confucianism during the late period of the Chosun Dynasty, and RRC is his representative work. RRC is a massive encyclopedia of natural history that covers vast areas of science from agriculture, floriculture, writing and drawing, architecture, diet, and medicine, among others which absorbed the achievements of CM, the best Materia Medica book at that time. Miki Sakae also highly regarded the encyclopedic knowledge of RRC, but devalued the results of Materia Medica. He only described a part of RRC's Materia Medica, nurturing volume, on the view of life nurturing and mentioned that it had been strongly influenced by China. According to this study, a large portion of RRC, especially regarding Materia Medica, depends on CM. Seo yugu had accepted the categorizing system and new medicinal information of CM, at the same time he modified the categorizing system of CM practically by the subject of each volume of RRC. We can find many quotations of CM except the nurturing volume, but other books, Treasured Mirror of Eastern Medicine, Materia Medica for Relief of Famines are also quoted. Furthermore, Seo yugu emphasized the differences of natural environments between Chosun and China, and specified the editing criteria, "to be useful in

  10. Reflecting the Steps of Modernization of Chinese Materia Medica from the Papers in Chinese Traditional and Herbal Drugs in 2009

    Institute of Scientific and Technical Information of China (English)

    LIU Yan-ze; DAN Yang; PENG Yong; XIAO Pei-gen

    2010-01-01

    The papers in the journal of Chinese Traditional and Herbal Drugs in Vol.40,2009 are briefly reviewed in thecategories of chemical constituents,preparations and technologies,analysis and quality control,pharmacologicaland clinical studies,reviews,and finally healthy principles.Some comments,especially for hot topics have beenpersonally provided.

  11. Application of zebrafish model organism in the research of Chinese materia medica%模式生物斑马鱼在中药研究中的应用

    Institute of Scientific and Technical Information of China (English)

    陈磊; 刘怡; 梁生旺

    2012-01-01

    Zebra fish has become an important model organism in many fields of biomedical studies and been increasingly used in Chinese materia medica studies in recent years. This article summarized the achievements and prospect for zebrafish as a pharmacological and toxicological tool in the study and development of Chinese materia medica.%斑马鱼作为一种新的模式动物,已经在生物医学的诸多研究领域得到了广泛的应用.近年来,基于斑马鱼的中药相关研究越来越多.本文重点综述了斑马鱼应用于中药药理、毒理研究方面的成果和前景.

  12. [The introduction of compendium of materia medica and praxis in the late Joseon dynasty].

    Science.gov (United States)

    Oh, Chaekun; Kim, Yongjin

    2011-06-30

    Sakae Miki said Classified Emergency Materia Medica had been the dominant standard of herbology throughout Joseon Dynasty, and that Compendium of Materia Medica had only been accepted so lately that a few books used herbological result of it in the late Joseon Dynasty. But according to Visiting Old Beijing Diary written by Munjoong Seo in 1690, Compendium of Materia Medica was in fact introduced before the year 1712, the year Miki Sakae argued to be the year Compendium of Materia Medica was accepted to Joseon officially. Now, we can assume that the introducing year of Compendium of Materia Medica was faster than Miki Sakae's opinion by the following reasons; the effort of Joseon government and intellectuals to buy new books of Ming & Ching; the publishing year of the book for living in countryside regarded as the first citing literature of Compendium of Materia Medica. And the True Records of the Joseon Dynasty and many collections written by intellectuals in the 18th century show that the herbological knowledge from Compendium of Materia Medica had already spread to the corners of Joseon Dynasty. Thus we can make the following assumption: Classified Emergency Materia Medica and Compendium of Materia Medica had coexisted in the late Joseon Dynasty. Sakae Miki suggested 6 examples which used Compendium of Materia Medica in the late Joseon Dynasty. I reviewed two of them in this paper, Essentials of Materia Medica & Handbook of Prescriptions from Materia Medica. Essentials of Materia Medica quoted Compendium of Materia Medica briefly focusing clinical use, and Handbook of Prescriptions from Materia Medica also re-compiled Compendium of Materia Medica to practical use according to the form of Treasured Mirror of Eastern Medicine. It means that the results of Compendium of Materia Medica have been used positively, based on the herbology of materia medica from countryside. From this point of view, the hyphothesis there weren't any herbological progress after accepting

  13. Stability and accuracy assessment of identification of traditional Chinese materia medica using DNA barcoding: a case study on Flos Lonicerae Japonicae.

    Science.gov (United States)

    Hou, Dianyun; Song, Jingyuan; Shi, Linchun; Ma, Xiaochong; Xin, Tianyi; Han, Jianping; Xiao, Wei; Sun, Zhiying; Cheng, Ruiyang; Yao, Hui

    2013-01-01

    DNA barcoding is a novel molecular identification method that aids in identifying traditional Chinese materia medica using traditional identification techniques. However, further study is needed to assess the stability and accuracy of DNA barcoding. Flos Lonicerae Japonicae, a typical medicinal flower, is widely used in China, Korea, and other Southeast Asian countries. However, Flos Lonicerae Japonicae and its closely related species have been misused and traded at varying for a wide range of prices. Therefore, Flos Lonicerae Japonicae must be accurately identified. In this study, the ITS2 and psbA-trnH regions were amplified by polymerase chain reaction (PCR). Sequence assembly was performed using CodonCode Aligner V 3.5.4. The intra- versus inter-specific variations were assessed using six metrics and "barcoding gaps." Species identification was conducted using BLAST1 and neighbor-joining (NJ) trees. Results reveal that ITS2 and psbA-trnH exhibited an average intraspecific divergence of 0.001 and 0, respectively, as well as an average inter-specific divergence of 0.0331 and 0.0161. The identification efficiency of ITS2 and psbA-trnH evaluated using BLAST1 was 100%. Flos Lonicerae Japonicae was formed into one clade through the NJ trees. Therefore, Flos Lonicerae Japonicae can be stably and accurately identified through the ITS2 and psbA-trnH regions, respectively.

  14. Practice and Consideration of Bilingual Education in Chinese Materia Medica%中药学双语教学的初步实践与思考

    Institute of Scientific and Technical Information of China (English)

    张大威; 刘立; 李思; 赵文昌; 彭新生; 崔燎; 吴铁

    2014-01-01

    对广东医学院中药学课程双语教学改革的实践进行总结和探讨,针对双语教学中出现的问题和不足提出可行的改进方案,为中药学专业其他专业课程双语教学的开展提供参考。参与教学实践的学生对双语教学的目的及意义有清晰的认识,同时对双语教学提出了更高的要求。如何保证学生对专业基本理论的掌握,不削弱或影响对专业基础知识的讲解和记忆,如何培养一批对中医中药具有扎实的专业基础知识和深刻理解,在国际上可以深入浅出以英文准确表述中医药基本观点的中医药双语专业人才是值得深入探讨的问题。%The aim of this paper is to review the teaching practice of bilingual education in Chinese Materia Medica in School of Chinese Medicine, Guangdong Medical College and propose possible solutions to problems in bilingual education pro-gram, in order to provide reference for the development of bilingual teaching in pharmaceutical professional and other profession-al courses. Students involved in the bilingual teaching program have a clear understanding of the purpose and meaning of the bilingual education program, while they expect more from bilingual education. It is worthy of further exploration to ensure that students master the general concepts of the course without weakening the understanding and absorbing of basic principles and contents, and to train a group of professionals that can gain solid foundation of professional knowledge and deep understanding of Traditional Chinese Medicine in the international community and correctly present the basic ideas and general concepts of Chinese medicine to English audience.

  15. Authentication of Polygonati Odorati Rhizoma and other two Chinese Materia Medica of the Liliaceae family by pharmacognosy technique with GC-MS analysis.

    Science.gov (United States)

    Liu, Yingjiao; Liu, Canhuang; Yu, Yafei; Xu, Bei; Gong, Limin; Zeng, Xiaoyan; Xiao, Lan; Cheng, Qilai; Liu, Tasi

    2015-02-01

    Yuzhu (Polygonati Odorati Rhizoma), Kangdingyuzhu (Polygonati Prattii Rhizoma), and zhugenqiyuzhu (Disporopsis Fuscopictae Rhizoma) are of the same family, but of different genera. They have all often used in Chinese Materia Medica (CMM) as Polygonati Odorati Rhizoma in China market. Three species of CMM are confused. For better application, we need to identify these plants accurately. This study use pharmacognosy technique and GC-MS analysis, three species of CMM were authenticated. In macroscopic characteristics, the fruit of Polygonati Odorati Rhizoma is blue-black, while the other two are maroon and dark purple orderly. Nodes of Polygonati Odorati Rhizoma are upward and light uplift, about 1 cm spacing, while the other are not. As for microscopic characteristics, the cortex of Polygonati Odorati Rhizoma only occupies about 1/5 of the radius of the transverse section with inconspicuous endodermis, which is much smaller than others. The type of vascular bundles of Polygonati Odorati Rhizoma is closed collateral, but the other is amphivasal. Raphides of calcium oxalate are scattered, but Raphides of the other two are like brooms and neat rows. GC-MS analysis of essential oil could provide different characteristics to distinguish three species. Twenty-three compounds were identified from essential oil of Polygonati Odorati Rhizoma and the main components were n-hexadecanoic acid (49.45%), while n-hexadecanoic acid of the other two are 23.92% and 9.45%. The content of n-hexadecanoic is strongly different. This research was aimed to establish a method by pharmacognosy and GC-MS analysis to identify three CMM and for providing scientifical data to ensure accuracy of origin of three species.

  16. 福建松溪县中药资源现状调查与分析%Survey and Analysis of Chinese Materia Medica Resources in Songxi County of Fujian Province

    Institute of Scientific and Technical Information of China (English)

    徐蔚; 韩静; 林燕华; 贺肇东; 周春权; 肖庆; 张继州; 胡娟

    2016-01-01

    目的:根据第四次全国中药资源普查试点工作要求,调查松溪县野生药用植物资源现状,为有效保护并合理利用当地中药资源提供科学依据。方法借助GPS 轨迹记录仪、单反相机等,采取样地、样线相结合的外业调查方法对该县药用植物资源展开调查记录。结果此次调查松溪县中草药资源142科,418属,共计615种,涉及国家重点调查品种85种,水生、耐盐中药资源33种。结论调查结果显示松溪县中药资源种类丰富,但部分品种蕴藏量有限,在开发利用的同时需注意加强保护以利于资源的可持续性。%Objective According to the requirements of the fourth national survey of Chinese materia medica resources, to investigate the medicinal plants in Songxi county and provide a scientific basis for the protection and utilization of the local resources. Methods Through the combination of sample-plot survey and line transect survey, the Chinese materia medica resources of Songxi County were investigated by the related equipment such as GPS position indicator, SLR camera and so on. Results There were 142 families, 418 genera and 615 species of Chinese materia medica resources recorded in the survey, including 85 species of national key investigated Chinese medicinal materials and 33 species of the medicinal plants which were aquatic or salt tolerant. Conclusion The results of the investigation in Songxi reveal that the Chinese materia medica resources of the county are rich in species diversity but some are inadequate in quantity, so it is necessary to maintain balance between the utilization and the conservation of the local resources for their sustainability.

  17. Study Progress on Pharmacodynamic Material Basis of Chinese Materia Medica%中药药效物质基础研究进展

    Institute of Scientific and Technical Information of China (English)

    郭倩; 田成旺; 任涛; 张铁军

    2015-01-01

    Study on pharmacodynamic material basis of Chinese materia medica (CMM) is one of the key points of CMM modern research. It is also the core of ascertaining the overall efficacy and the function essence of CMM. It is an important basis for the safety, efficacy and quality control of CMM. However, since the multiple components, complex medical effects and interactions among effective components of CMM, the clarification of pharmacodynamic material basis has become a difficult question, which restricts the CMM modernization. Therefore, pharmacodynamic material basis of CMM has received widespread attention in the academic field. Many experts and scholars have done a lot of research and practice on this area. This article analyzed relevant literatures about pharmacodynamic material basis researches of CMM, and reviewed connotation, research thoughts and methods of CMM. It discussed some existing problems in current studies. The goal was to provide references for pharmacodynamic material basis of CMM.%中药药效物质基础研究是中药现代研究的关键点之一,是阐释中药整体功效及其作用本质的核心环节,是中药安全、有效和质量控制的重要基础.但由于中药多成分和药效作用的复杂性,以及中药各有效成分的协同作用,使得中药药效物质基础的阐明成为难题,制约着中医药的现代化进程.因此,中药药效物质基础目前已受到学术界的广泛重视,许多专家学者对此进行了大量的研究和实践.本文通过回顾、分析近年来中药药效物质基础研究的相关文献,综述了中药药效物质基础的内涵、研究思路和方法,并探讨了目前研究中存在的一些问题,以期对中药药效物质基础研究提供参考.

  18. Pharmacological research on Chinese materia medica in Modern China and TCM%近代中药药理研究与传统中医药学

    Institute of Scientific and Technical Information of China (English)

    赵际勐

    2012-01-01

    The experimental pharmacological research on Ma - Huang and Tang - Kuei (Danggui) by Chen Kokuei and his colleagues in 1923,is the proem of scientific research on Chinese materia medica (CMM) in China.In the 1930' s,a number of scientific research institutions were established in China,such as,the Institute of Physiology,National Academy of Peiping and the pharmaceutical laboratory of the experimental hygiene station,National Economic Council.Experts undertook extensive research on CMM.They injected the rough extractum or purified active constituent in laboratory animals to observe the characteristics of drugs and published a series of treatises.They made experimental objectives and selected experimental herbs according to TCM theory.Their inheritance and innovation in the research demonstrated better rationality than simultaneous overseas scholars to whom they were therefore superior.%1923年陈克恢等对于麻黄、当归的实验药理研究是我国近代中药药理研究的开端.20世纪30年代,国内相继建立起一批科研机构,如国立北平研究院生理学研究所、全国经济委员会卫生实验处药物研究室等,广泛地开展了中药的药理研究,将中药粗制浸膏或精制有效成分注入实验动物体内,观察药物作用的特点,陆续发表了多篇研究论文.在研究过程中,他们根据传统中医药知识确定实验目标,借鉴传统知识选用实验药材,在探索中继承和创新,表现出比同时期国外学者的自然药物实验研究更强的合理性和优越性.

  19. Four properties law of nature data of Chinese materia medica in "Chinese herbal medicine (CHM)"%《中华本草》药性数据中的四气规律

    Institute of Scientific and Technical Information of China (English)

    杨雪梅; 林端宜; 赖新梅; 陈梅姝; 黄璐琦

    2013-01-01

    目的:以四气为核心,分析中药药性数据中气与味、归经、毒性之间的相关关系,为中医临床用药、中药实验研究、中药新资源开发等提供理论线索和数据支持.方法:在对数据等级编码基础上,采用spearman等级相关法对《中华本草》中8 356味具有四气属性中药的药性规律进行分析.结果:四气与辛、甘2味存在显著正相关(P<0.01);与苦、淡2味存在显著负相关(P<0.01);与脾、胃、肾三经存在显著正相关(P<0.01);与大肠、心、膀胱、胆、小肠、肺六经(按相关性递减排序)存在显著负相关(P<0.01);与毒性之间存在显著正相关(P<0.01).结论:药性越“热”则越可能具有辛、甘2味,越常入脾、胃、肾三经,其毒性更大;药性越“寒”则越可能具有苦、淡2味,越常人大肠等六经.%Objective:In order to provide theoretical clues and data support for the use of Chinese medicine clinical drug,experimental study of Chinese materia medica and development of new resources of Chinese materia medica,the four properties as the core,the relationships of property,flavor,channel tropism and toxicity in nature data of Chinese materia medica were analyzed.Method:The spearman rank correlation method was employed to analyze 8 356 Chinese drugs with characteristic of four properties from "Chinese Herbal Medicine" based on data level coding.Result:It was discovered that four properties showed significant positive correlations with tastes of "pungent and sweet",channels of "spleen","stomach","kidney" and "toxicity",but also showed significant negative correlations with tastes of "bitter" and "hght" and six channels such as "large intestine","heart"," bladder","gallbladder","small intestine" and "lung" (in descending order of correlation) (P <0.01).Conclusion:It was indicated that the more hot the Chinese medicine nature,the more possible it contained "toxicity",tastes of "pungent" and "sweet",and the more

  20. Theoretical Analysis on Nature of Fixed and Itinerant Effects in Chinese Materia Medica%中药走守药性的理论探析

    Institute of Scientific and Technical Information of China (English)

    韦乃球; 邓家刚; 冼寒梅; 韦建信

    2015-01-01

    中药药性理论是祖国医药理论体系中的重要组成部分,是中国历代医家在长期的医疗实践中,以阴阳、五行、脏腑、经络、治则等中医理论为基础,根据药物的性质特征及患者用药之后的反应而高度概括的一种理性认识.自古以来,中药药性理论一直指导着中医临床的准确辨证施药,对中华民族的医疗保健和繁衍生息有着不可磨灭的贡献.中药药性理论是学习、研究、运用中药所必须掌握的基本理论知识,其概念内涵包括四气、五味、归经、升降浮沉、毒性、补泻、润燥、滑涩、刚柔、走守、峻缓等内容.可见,以走守概括中药的作用特征,亦是中药药性理论的组成内容之一.虽然历代医家对中药走守药性的论述尚显凌乱,但该药性对于阐释药物作用机理以及临床选药、配伍组方的指导意义却不容忽视.%Theory of Chinese materia medica (CMM) nature was an important part in traditional Chinese medicine (TCM) theoretical system. During the long term practice, based on TCM theories of yin and yang, five elements, zang-fu, meridian and treatment principle, herbal features and patients' reactions were highly summarized into recognition and understanding. Since ancient time, theory of CMM nature has always guided the accurate syndrome differentiation and medication in TCM clinical practice. It contributed to the healthcare and reproduction of Chinese people. Theory of CMM nature is the basic theoretical knowledge which must be mastered in the study and research. Its concepts contained four-qi, five tastes, channel tropism, ascending and descending, toxicity, tonification and reducing, moisture and dryness, smooth and astringent, softness and hardness, fixed and itinerant effect, strong and mild. Using fixed and itinerant effects in the summarization of CMM function is one of the components in CMM nature theories. Although discussions on this theory from practitioners

  1. Current research status of identification method for Chinese materia medica based on bionic olfaction%基于仿生嗅觉的中药材鉴别方法研究现状*

    Institute of Scientific and Technical Information of China (English)

    周华英; 李钟; 刘红秀

    2016-01-01

    概述了中药材“气味”鉴别的重要地位;综述了仿生嗅觉技术机理及其在中药材鉴别领域的研究现状,同时展望了仿生嗅觉技术在中药材领域的应用前景。%The importance of "odor" identification is introduced in this paper. Then the mechanism of the bionic olfactory technology,as well as the current research status about the identification of Chinese herbal medicines based on the technology is summarized;Lastly,some conclusions and application prospect about the bionic olfactory technology in the field of Chinese materia medica will be discussed.

  2. 自乳化释药系统在难溶性中药制剂中的应用%Self-emulsifying delivery systems and its application on preparations of poorly soluble Chinese materia medica

    Institute of Scientific and Technical Information of China (English)

    叶珍珍; 张建; 崔升淼

    2012-01-01

    自乳化释药系统可以提高难溶性药物的溶出度和生物利用度,在中药方面的应用具有良好的发展前景.文章综述自乳化释药系统的定义、特点、体内外质量评价指标、在难溶性中药制剂中的应用以及存在问题与对策.%The dissolution and the bioavailability of water-insoluble drugs can be improved by the utilization of serf-emulsifying delivery systems (SEDDS), so SEDDS has a promising application in the field of Chinese medicine. The definition, characterization, indexes in vivo and in vitro evaluations, application to preparations of poorly soluble Chinese materia medica, problems and countermeasures are reviewed.

  3. Chinese Marine Materia Medica. By Huashi Guan and Shuguang Wang. Shanghai Scientific and Technical Publishers, China Ocean Press, and Chemical Industry Press: Shanghai, Beijing, China, 2009; Hardback, 7064 pp; ¥ 2920; ISBN 978-7-5323-9958-1/R•2707; ISBN 978-7-5323-9973-4/R•2708; ISBN 978-7-1220-6012-9

    Directory of Open Access Journals (Sweden)

    Peter Proksch

    2014-01-01

    Full Text Available China is one of the first countries to use marine materia medica for treating diseases. Ancient books on Chinese herbology, such as Shennong Bencaojing (Shennong’s Classic of Materia Medica, Xinxiu Bencao (Newly Revised Materia Medica and Bencao Gangmu (Compendium of Materia Medica, have detailed more than 110 marine herbs and thousands of marine herbal formulas (including those for Chinese food therapy. A great deal of information on marine herbs and their applications in medicine, collected over thousands of years, has provided an important foundation for modern research in the area of marine drugs. Thanks to these records and references, the research and development of modern Chinese marine drugs continue to evolve and mature. Since the middle of the 20th century, special attention has been paid to traditional Chinese medicine, resulting in a significant increase in the number of newly discovered marine herbs. Comprehensive surveys in the past have also created a wealth of data on the pharmacology, chemistry, biology and ecology of marine medicinal bioresources. After thousands of years of research, historical references to traditional marine herbs are scattered throughout ancient books, local chronicles, medical books, or monographs on medicinal herbs. Unfortunately, there is no systematic way to collate or scientifically verify these references. Furthermore, during the last century, scientists around the world have accumulated large quantities of information on marine natural products, but these are also scattered throughout academic books and journals.

  4. Differences of Bi-directional Regulative Effects between Acu-moxibustion and Chinese Materia Medica Interventions%针灸和中药双向调节特征之异同

    Institute of Scientific and Technical Information of China (English)

    曹新; 余芝; 徐斌

    2012-01-01

    双向调节是指当机体由于内在或外在因素导致功能亢进或低下时,针灸和中药干预所发挥的平衡效应.通过分析针灸和中药的作用特点,认为针灸和中药的双向调节效应均为多向整体性调节的一种特殊表现,其效应的发挥都与机体的功能状态有关.由于二者治疗性质和作用途径不同,使二者双向效应发挥的基础和模式不同.双向调节是腧穴效应的个性体现,以经络辨证和脏腑辨证为基础;针灸的双向调节效应是多种因素共同作用的结果,其模式以趋中性调节为主.中药双向调节效应的发挥是建立在药证对应的基础上,其调整作用的产生是以所含的拮抗性成分为物质基础,作用模式包括趋中性调节和偏离性调节.%Bi-directional regulation is referred to a balancing effect of both acu-moxibustion and Chinese materia medica interventions when the human body is experiencing a hyperactivity or hypoactivity due to abnormal intrinsic or external factors. In the present paper, the authors analyze their identical and different characteristics from: 1) definitions 2) characters of regulative effects of acu-moxibustion therapy: A) differentiation of meridian and zangfu-organs being the basis of treatment, B) four factors (acupoint-location, body's functional state, acupoint-formula and needle-manipulation techniques) dependant, C) entirety regulation, and D) centrotaxis modulation; 3) characters of Chinese materia medica intervention: including a)correspondence between the drug property and the syndrome being the basis of the regulative effect, b) multi-factors [components (antagonist and agonist) , combination, dosages and processing quality of Chinese materia medica, and functional state of the human body] dependant, c) entirety regulation, and d) both centrotaxis and deviation adjustment. In one word, the bi-directional regulation effect is one of the basic characteristics of both acu-moxibustion and

  5. 基于PBL的海外留学生中药学教学模式%Teaching Mode of Chinese Materia Medica to Overseas Students in China Based on Problem-based Learning

    Institute of Scientific and Technical Information of China (English)

    王君明; 崔瑛; 贾玉梅

    2013-01-01

    As more and more overseas students to learn in China for knowledge and skills of Chinese medicine, teaching methods have become a hot topic commonly concerned by educators. Problem-based learning (PBL) is considered to be an excellent teaching philosophy and has already attracted much attention and applications in many domestic disciplines since it has been widely used in European and American countries. In the present paper, the authors have put forward a teaching mode of Chinese materia medica to overseas students in China based on PBL on the basis of years of teaching experience. This paper provides methodological guidance and ideas for reference for teaching Chinese materia medica for overseas students in China. Besides, the present paper also provides a meaningful reference for other subjects to carry out teaching abroad students in China.%  随着越来越多海外留学生来华学习中医药知识和技能,留学生教学方法优化改革已成为从事留学生中医药各科教学的教育工作者共同关心的话题.PBL(Problem-based Learning)被认为是一种优秀的教学方法,自从在欧美国家广泛应用以来,近年来也引起国内许多学科的关注及应用.作者结合海外留学生学习特点、PBL教学理念、中药学课程特点,并在PBL教学实践的基础上,首次提出了基于PBL的海外留学生中药学教学模式.本文将为中药学生或其他学科留学生课程的教学改革提供有意义的参考.

  6. Innovative Progress of the Separation & Purification Technologies in the Production of Chinese Materia Medica Preparation%中药制剂分离与纯化技术创新进展

    Institute of Scientific and Technical Information of China (English)

    陈秦娥; 梁金龙

    2012-01-01

    论述了深入研究中药制剂分离技术创新进展的意义,概述了固液分离技术在中药制剂中的重要作用,首次全面总结了14种制药分离与纯化主要设备的重大发展历程及创新特征,首次系统剖析了14种中药制剂提取分离与纯化高新技术原理特性和应用效果,首次研究阐明了现代中药制剂分离与纯化技术主要呈现的新老技术复合化、高技术超常化和新技术多样化三大发展趋势。%This paper discussed the significance of deep investigation on the innovative progress of separation & purification technologies in the production of Chinese materla medica preparation and summarized the important function of solid-liquid separation technology during the production process. Meanwhile, this study reviewed the momentous development course and innovative characteristics of the fourteen major separation & purification equipments, analyzed the principles and applies of separation & purification technologies systematically. It was clarified in the paper that compounding of old and new technologies, the practical application of high tech and the diversity of new tech were the three development trends on separation & purification technologies in the production of Chinese materia medica preparation nowadays.

  7. Authentication of the 31 species of toxic and potent Chinese materia medica by microscopic technique assisted by ICP-MS analysis, part 4: four kinds of toxic and potent mineral arsenical CMMs.

    Science.gov (United States)

    Li, Qin; Chu, Chu; Wang, Ya-Qiong; Chen, Hu-Biao; Li, Ping; Zhao, Zhong-Zhen

    2011-01-01

    Toxic and Potent Chinese Materia Medica (T/PCMM) is a special and very important category of Chinese medicines. They have long been used in traditional medical practice and are being used more and more widely throughout the world in recent years. As there may be many fatal toxic effects caused by misusing or confusion of T/PCMM, their quality and safety control arouse increasing attention internationally. Researches on the accurate identification to ensure the safe use of T/PCMM are acquired; however, there are few reports on authentication. We are carrying out a series of studies on 31 T/PCMM originating from plants, animals, minerals, and secreta. In our previous studies, we proved that modern microscopic authentication is a simple, fast, effective, low cost, and less toxic method for identifying animal, seed, and flower T/PCMM. In the present study, we focused on the authentication of four kinds of mineral arsenicals, including orpiment (mainly containing As₂S₃), realgar (mainly containing As₄S₄), arsenolite, and arsenic trioxide (mainly containing As₂O₃). We examined the macroscopic and microscopic characteristics of the above minerals and found that they all can be easily identified and authenticated by using light microscopy coupled with polarized microscopy. Moreover, the authentication results for arsenolite and arsenic trioxide are confirmed by ICP-MS analysis. We are sure that the morphological and microscopic characteristics indicated here are indispensable to establishing standards for these four mineral T/PCMMs.

  8. Importance of TCM Mindset Cultivation in the Education of Traditional Chinese Materia Medica Specialty at Agricultural and Forestry Universities%中医思维培养在农林院校中药专业教育中的重要性

    Institute of Scientific and Technical Information of China (English)

    史红专; 朱再标; 刘丽; 郭巧生; 王长林

    2014-01-01

    侧重于中药材生产的中药学相关专业的中医药基础课程培养目标和要求不同于传统中药学专业。本文从农林院校中药专业的教学目的、学生的生源、课程设置等角度着手,结合当前的教育体制和中医药学科特点,提出对农林院校中药专业学生进行中医思维培养的重要性。%The objective and request of course in Basis of traditional Chinese medicine (TCM)of Chinese materia medica relevant specialty which place emphasis on medicinal materials production differ from those of traditional Chinese materia medica specialty.In this review,we point out that it is of great importance for the students of Chinese materia medica specialty in agricultural and forestry universities to cultivate the TCM mindset,in the perspectives of teaching objectives,source of students,curriculum,and the present education system as well as the discipline characteristic of TCM.

  9. Progress of Experimental Study on Treatment of Psoriasis by Chinese Medicinal Monomer and Single or Compound Recipe in Chinese Materia Medica

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Psoriasis is a common,chronic,recurrent inflammatory skin disorder whose etiology is still unknown.It is believed that a multiple-gene inheritance is involved and it also involves various factors such as immunity,inflammation,cell proliferation,apoptosis,neural media,etc.Since cytokines are key mediators in inflammation,a number of Chinese medicines(CMs)have been reported to have certain antagonist effects on pro-inflammatory cytokines such as tumor necrosis factor-a(TNF-α),platelet active factor(PAF)and interleukin-8(IL-8).Some researches on CMs have made significant breakthroughs in psoriasis by intervening with cytokines.Abnormalities with keratinocyte proliferation and apoptosis are considered to be present in patients with psoriasis and a number of studies show that the mechanism of CMs on psoriasis may be through the inhibition of the keratinocyte proliferation and induction of apoptosis.Other studies also show that the inhibition of fibroblast-secreted cytokines could regulate keratinocyte proliferation and differentiation and reduce the level of Calcitonin gene-related peptide(CGRP)in plasma and in lesions so as to slow down the process of inflammation and proliferation in psoriasis.The most commonly used models for psoriasis are the scaled tails or the vaginal epithelium of mice in China.They were used to observe the histopathological changes after the model mice were treated with CMs with the inhibition on the mitosis of vaginal epithelium or promotion of granular layer in rat tail taken as the indices of clinical efficacy.A variety of signs occur in psoriasis patients with TCM blood-stasis syndrome type and the effect of CMs in activating blood circulation to remove blood stasis on psoriasis suggested that the mechanism of CMs may be partially correlated to hemorrheology and microcirculation.Along with the continuous development of the biosciences,some TCM theories for psoriasis have been confirmed by laboratory studies.However,the exploration into

  10. [The translation and its meanings of Materia Medica Part. I in the Jejungwon].

    Science.gov (United States)

    Park, Junhyoung; Park, Hyoungwoo

    2011-12-31

    For more systematic medical education, Dr. O. R. Avison translated medical textbooks into Korean since he took charge of Jejungwon in 1893. The first book he chose was Anatomy of the Human Body. He, however, failed to see it published after losing its manuscript twice. Instead, Materia Medica Part. I was brought into the world first in 1905, for which he translated Materia Medica and Therapeutics written by John Mitchell Bruce from the U. K. At that time, this book was in widespread use in the English-speaking world as a textbook for pharmacology. It is also assumed that Avison used it as a textbook for his classes in Canada before coming to Korea. For the publication of Materia Medica Part. I, Avison did not translate Bruce's original text in full, but translated only the selected passages. He followed a principle of using Korean alphabets (Hangeul) only, but in combination with Chinese characters, if necessary. He put pharmacological terms into existing Korean equivalents or newly coined words, but also borrowed many from Japanese terms. That's because Japan moved faster to introduce Western medicine than Korea did, so that many pharmacological terms could be defined and arranged more systematically in Japanese. Moreover, Japan took such a favorable stance in the state of international affairs that many of Japanese-style terms could be introduced into Korea in most fields including medicine. By translating Materia Medica Part. I in cooperation with his disciple KIM Pilsoon after Gray's Anatomy of the Human Body, Avison tried to lay groundwork for providing medical education in Korea based on the British-American medicine. It is assumed that he took an independent stance in selecting and translating Western medical textbooks on his own rather than simply accepting the existing Chinese translation of Western medical textbooks. Despite all his efforts, he might find it difficult to translate all the Western medical terms into Korean within a short period of time

  11. Five Flavors Law of Nature Data of Chinese Materia Medica in "Chinese Herbal Medicine"%《中华本草》药性数据中的五味规律

    Institute of Scientific and Technical Information of China (English)

    杨雪梅; 赖新梅; 陈梅妹; 林端宜

    2013-01-01

    目的 以五味为核心,分析中药药性数据中味与气、归经、毒性之间的相关关系,为中医临床用药、中药实验研究、中药新资源开发等提供药味理论的新线索和数据支持.方法 在对数据等级编码基础上,采用spearman 等级相关法对《中华本草》中8 366味具有五味属性中药的药性规律进行分析.结果 在P<0.01显著水平,酸味与肝、大肠、胃三经存在显著正相关,苦味与寒性肝、大肠、胆三经及毒性存在显著正相关,甘味与热性及肾、肺、脾等八经存在显著正相关,辛味与热性和脾、胃、肝、肺四经及毒性存在显著正相关,成味与肾、肝、心、肺四经存在显著正相关,淡味与寒性及膀胱、小肠二经存在显著正相关,涩味与大肠经存在显著正相关.结论 辛、甘二味属阳,苦、淡二味属阴.《内经》中归纳的“酸入肝”、“甘入脾”、“成入肾”规律获得大数据集验证,而“苦入心”理论未获数据支持,“辛入肺”规律仅获数据部分支持.辛、苦二味越重药物毒性越大,提示针对体质较弱、病情较轻的患者应谨慎使用辛、苦二味较重的药物.%Objective To provide theoretical clues and data support for the use of Chinese medicine clinical drug, experimental study and development of new resources of Chinese materia medica, by analyzing the relationships of property, flavor, channel tropism and toxicity in nature data of Chinese materia medica with five flavors as a core. Methods The spearman rank correlation method was employed to analyze the nature law of 8 366 Chinese drugs with characteristic of five flavors from "Chinese Herbal Medicine" based on data rank coding. Results On the significant level of P<0.01: sour showed significant positive correlations with three channels (liver, large intestine and stomach). Bitter showed significant positive correlations with cold and three channels (liver, large intestine and

  12. 参与式教学法在中药炮制学中的探索与实践%Exploration and Practice of Participation-Model Didactics on Processing Science of Chinese Materia Medica

    Institute of Scientific and Technical Information of China (English)

    王满元; 卢炜

    2014-01-01

    To assess the feasibility of the participation-model didactics on processing science of Chinese materia medica ,the effects of the teaching model were analysized and sumarized .The positive results verify the effectiveness of the didactics on developing students'creativity and improving their professional ability as well as transferable skills.Combination of participation-model didactics with traditional teaching model can help students improve their learning levels.%参与式教学法重视教学过程中“学”的因素,重视师生“对话”互动交流,有助于提高学生的综合能力与创新意识。该文归纳总结在中药炮制学课程中应用参与式教学的具体方法和实施途径。传统教学中加入参与式教学元素,两者有机结合,能够提高中药炮制学的教学质量。

  13. 知识网络图教学法在中药药理学教学中的运用%Application of knowledge network method in teaching pharmacology of Chinese materia medica

    Institute of Scientific and Technical Information of China (English)

    畅洪昇; 张硕峰; 孙文燕; 董世芬; 孙建宁

    2015-01-01

    针对中药药理学课程内容要素众多、教师教学困难、学生学习效果差的教学现状,本研究将知识网络图作为组织和设计课堂教学、教学效果评价的工具引入中药药理学的教学中。实践表明,该方法不仅可以突出教学内容的整体层次和内在关联,提高教学质量,而且可以激发学生对专业知识的学习兴趣,提高学生探索未知知识、完善知识结构的自主学习能力。%Aiming at the present teaching conditions, this paper attempted to apply knowledge network in the classroom teaching and teaching effectiveness evaluation of pharmacology of Chinese materia medica. Our practice shows that this method may help highlight overall level and internal relation of the teaching contents, improve teaching quality, stimulate students’interest in learning, and increase their self-dependent learning ability.

  14. A discussion on the reasons of differences between property and flavor of Chinese Materia Medica of ancient and modern times%古今中药性味不统一的原因探讨

    Institute of Scientific and Technical Information of China (English)

    张效霞; 王振国

    2009-01-01

    The property and flavor (four properties of cold, hot, warm, cool and five flavors of spicy, sweet, bitter, sour, salty)which marked the function and efficacy of Chinese Materia Medica had dif-ferent records in TCM ancient literature, even being completely opposite. By analyzing the reason, it mainly involves such aspects as different properties of soil and water, different harvesting seasons, incorrect nomen-clature not corresponding to reality, different angles, double properties and flavors, former mistakes and lat-ter corrections, different processing methods etc.%标示中药性能功效的性味(寒热温凉四气和辛甘苦酸咸五味),在中医文献中的记载并不一致,甚至截然相反.分析其原因,主要有水土质异、采收季节不同、名实讹误、角度不同、性味双重、前错后改、炮制方法等几个方面.

  15. Construction of biopharmaceutics classification system of Chinese materia medica%多成分体系下中药生物药剂学分类系统的构建分析

    Institute of Scientific and Technical Information of China (English)

    刘洋; 隗丽; 董玲; 朱美玲; 唐明敏; 张雷

    2014-01-01

    基于中药的多成分特点,借鉴化药领域的生物药剂学分类系统(biopharmaceutics classification system,BCS)理念、方法和技术,提出了中药生物药剂学分类系统(biopharmaceutics classification system of Chinese materia medica,CMMBCS)的科学框架.在学术思想阐述和理论分析的同时,构建了基于多成分层次差异比较法和中药整体CMMBCS研究法的方法流程,明确了该系统用于揭示中药多成分吸收的相互影响及相关机制的基础性作用,也为提高中药质量标准和开发中药新药提供了新的思路和方法.

  16. Technology, unit operation, transference, and process engineering of Chinese materia medica%中药生产工艺、单元操作、传递及过程工程学

    Institute of Scientific and Technical Information of China (English)

    刘明言; 张慧慧

    2011-01-01

    根据过程工程学的基本理论及发展历史、中药生产过程的发展现状,从系统工程角度分析了中药生产过程各环节的过程工程学特点,分析中药过程工程学这一更为宽广视野的概念,从新的视角对中药过程工程学的研究内容进行了阐述,并探讨了本领域的研究新进展.%According to the basic theories of process engineering and their developing histories, considering the development of pharmaceutical industry of Chinese materia medica (CMM), the process engineering features in all sectors of the CMM whole production process were discussed on the point of systematical engineering, and a wider concept of CMM process engineering was suggested. Its research contents were analyzed and lastest achievements were reviewed in this paper.

  17. The significance of drawing on experience of experimental study on Chinese materia medica during the Republican period%民国时期中药实验研究的借鉴意义

    Institute of Scientific and Technical Information of China (English)

    李楠; 万芳

    2015-01-01

    民国时期,随着中医药科学化进程,中药实验研究广泛开展.虽然当时技术水平相对落后,结论参考价值有限,但这一时期取得的经验和教训,对今天的中药科研工作仍具有借鉴意义.诸如挖掘古代中医药文献中所蕴藏的宝贵经验、中药科研工作应当在中医药理论指导下进行、提高科研成果转化能力等理念,已为当今中医药科研工作者所接受,而回顾历史可知,这些理念是在中医药生死存亡关头,通过前人的反复实践而总结形成的,到任何时候都应反复强调,深化理解.%During the period of the Republic of China,researches of experiments on Chinese materia medica developed extensively with the scientific process of Chinese medicine.Although the technology standard was relatively low and the reference value,limited.The experiences,positive or negative,obtained at that time still has reference significance to today' s Chinese medicine scientific research.The notion that traditional Chinese medical and scientific research be conducted under the guidance of TCM theory;valuable experience contained in the ancient literature of traditional Chinese medicine be collected;and the transformation capacity of scientific research be elevated,has been accepted by modern TCM professionals.If you go back to the history,it can be seen that this notion was summarized through repeated practice during the critical moment of traditional Chinese medicine,which should be emphasized and its understanding deepened at any time.

  18. 中药延缓衰老作用机制研究进展%Research progress on mechanism of delaying senility of Chinese materia medica in recent years

    Institute of Scientific and Technical Information of China (English)

    高会丽; 王丹巧

    2009-01-01

    近年来探讨中医药延缓衰老多种机制,寻找高效的延缓衰老药物已成为当前我国中医药领域研究的热点之一,并取得一定的进展.文章就近年来中药延缓衰老作用机制的研究进展进行综合分析.现代研究表明,中药及其复方可以通过抗自由基氧化,调节神经内分泌代谢,平衡免疫功能,延长细胞端粒长度和增强端粒酶活性,抗细胞DNA损伤以及调节与细胞增殖相关基因和蛋白的表达而达到延缓衰老目的.%Recently investigating mechanisms on delaying aging of traditional Chinese medicine(TCM) and discovering high effective related medicines have been become hot spot and have achieved some progress.This review comprehensively analyzed the mechanism of TCM on delaying senility in recent years.The modern researches have demonstrated that Chinese materia medica and compound formulas can retard aging process by anti-oxidant activity of free radical,modulating metabolism of neuroendocrine,balancing immunological function,prolonging telomere length and promoting telomerase activity in cells,anti-DNA damage of cells,and controlling expression of gene and protein involved in cell proliferation.

  19. Research progress and thinking on solidification nanosuspensions drug delivery system of Chinese materia medica%中药固体化纳米混悬给药系统的研究进展与思考

    Institute of Scientific and Technical Information of China (English)

    岳鹏飞; 万晶; 胡鹏翼; 郑琴; 王勇; 杨明

    2012-01-01

    纳米混悬给药系统为改善难溶性中药成分的溶解度和生物利用度提供了一条新的途径.研究具有再分散性能的固体化纳米混悬给药系统,是实现纳米混悬系统稳定化的理想选择,然而,固体化再分散后是否仍呈纳米状态,能否保持良好的再分散性,仍然是亟待解决的关键科学问题.主要综述了中药纳米混悬系统固体化的研究现状,并分析了纳米混悬系统固体化及其再分散稳定性的研究策略,以期“抛砖引玉”,进一步促进中药纳米混悬给药系统制剂理论的完善与发展.%Nanosuspensions (NS) drug delivery system is used as a novel approcah to improve the solubility and bioavailability of poorly soluble ingredients in Chinese materia medica (CMM). Studying on solid redispersibility nanosuspension drug delivery system is the main choice for stabilization of nanosuspension system. However, whether solid is still in nano state after redispersing or can keep good redispersibility is an urgent scientific point. This paper reviews the research status of nanosuspensions system solidification and analyzes the research strategy of nanosuspensions system solidification and redispersion stability in order to "initiate" further investigations and studies to promote and develop the theory of CMM nanosuspension drug delivery system.

  20. [The research on the edition of Daquanbencao (Complete Collection of Materia Medica)].

    Science.gov (United States)

    Li, Jian; Zhang, Wei; Zhang, Rui-xian

    2009-07-01

    Zhengleibencao (Classified Materia Medica) had been formed into several kinds of edition systems during its dissemination, among which there was the edition system of Daquanbencao (Complete Collection of Materia Medica). Daquanbencao was originally carved in the Jin dynasty, thereafter it was re-carved in the Yuan, Ming and Qing dynasties so as to form a series of editions such as the edition of Zhenyou in the second year of the Jin dynasty; the edition of the Zongwenshuyuan college in Dade renyan year of the Yuan dynasty; the WANG Qiu's carved edition of Shangyitang hall in the Ming dynasty; the carved edition of Jishanshuyuan, the Jishang mountain college in the Ming dynasty, the reprinted edition of PENG Duan-wu in the Ming dynasty, the supplementary edition of YANG Bi-da in the Qing dynasty;, and the carved edition of KE Feng-shi in the Qing dynasty. Among all the editions, Chongkanjingshizhengleidaquanbencao (Reprinted Classified Daquan Materia Medica from Historical Classics) was the representative one. As a representative of the above editions, the carved edition of WANG took the edition of the Zongwenshuyuan college of the Yuan dynasty as the original edition, but the images picture of materia medica adopted from the edition of Zhenghebencao (Materia Medica of the Zhenghe era).

  1. 基于道地药材和生物测定的中药质量控制模式与方法研究——工作参照物%Investigation on pattern of quality control for Chinese materia medica based on famous-region drug and bioassay——the work reference

    Institute of Scientific and Technical Information of China (English)

    鄢丹; 肖小河

    2011-01-01

    针对中药质量生物评价与控制中面临的重要技术问题--工作参照物的选择与标化,以黄连质量生物评价控制为例,从基原鉴定、常规检查、化学组分分析和生物测定等角度对其工作参照物(道地药材提取物)的研制过程进行阐释,凝炼共性技术,形成具有普适性的中药质量生物评价与控制用工作参照物的选择与标化流程,以期为构建基于道地药材和生物测定的中药质量控制模式与方法提供技术参考.%Selection and standardization of the work reference are the technical issues to be faced with in the bioassay of Chinese materia medica. Taking the bioassay of Coptis chinensis. as an example, the manufacture process of the famous-region drugs extraction was explained from the aspects of original identification, routine examination, component analysis and bioassay. The common technologies were extracted, and the selection and standardization procedures of the work reference for the bioassay of Chinese materia medica were drawn up, so as to provide technical support for constructing a new mode and method of the quality control of Chinese materia medica based on the famous-region drugs and bioassay.

  2. Discussing the Safety Application of Chinese Materia Medica in Patients with Cardiovascular Diseases%心血管病患者使用中药安全性探讨

    Institute of Scientific and Technical Information of China (English)

    张俭; 张敏州; 孔祥照

    2012-01-01

    随着中医药事业的发展,中药在国内外的使用越来越广泛,但是伴随而来的是缺乏安全性证据、自身制作工艺欠成熟、医务人员对毒性认识不足、公众误区等问题的日益严重,尤其对于心血管病患者,因此,需要我们心血管病科医师提高对中药制剂及其作用、副作用的认识,并且要监督及鉴别中药-西药的相互作用,同时要求科研工作者通过严格的实验设计评估中药的安全性和有效性,进一步提高中药的质量、安全性和有效性,严格制定产品说明规范,宣教引导临床医师和普通大众对中药的合理使用.%Along with the development of Chinese medicine and pharmacy ( CMP), Chinese materia medica (CMM) has been used more and more widely at home and abroad. But we have to confront worsening problems such as lack of safety evidence, immature self - formulation technologies, lack of knowledge about their toxicities, and public misunderstanding, especially for patients with cardiovascular disease (CVD). Therefore, we cardiovascular physicians are requested improve knowledge for CMM preparations and their effects and side effects, supervise and identify the interactions between CMM and Western medicine. Meanwhile, the researchers are also requested to assess the safety and efficacy of CMM through rigorous experimental designs, further improve the quality, safety, and efficacy of CMM, strictly formulate the specification of CMM products, guide the rational use of CMM by clinicians and the general public.

  3. Progress in microbiome and its application to pharmacological and toxicological research of traditional Chinese materia medica%肠道微生物组及其在中药药理毒理研究中的应用

    Institute of Scientific and Technical Information of China (English)

    邓红; 吴纯启; 江涛; 王全军

    2016-01-01

    微生物组是一新兴研究领域,其研究涉及人类健康、农业、生物能源和环境等领域。其中,肠道微生物组是近年研究的热点。已有研究表明,肠道菌群与消化道疾病(炎症性肠病)、代谢性疾病(2型糖尿病)、心脑血管疾病(帕金森征)等有关。中药常作为补益药而长期大量服用,其口服进入胃肠道后,肠道菌群可影响中药药理和毒理作用。本文主要综述了微生物组的基本概况、常用的检测技术及其与何首乌所致肝毒性、黄芩直接作用于肠道、泽泻所致肾毒性及小柴胡汤所致肺炎等为代表的几种毒性作用间的关系。%Microbiome is a novel research field related to human health,agriculture,bio-energy and the environment. Gut microbiome has received much attention from researchers recently. Studies have shown that gut flora is related to some diseases,such as digestive disease(inflammatory bowel disease),metabolic disease(type 2 diabetes), cardie-cerebral vascular disease(Parkinson disease). Traditional Chinese materia medica(TCMM) has long been used as a tonic and taken in a large amount. Gut flora has an effect on pharmacology and toxicology of TCMM after entering the gastroin⁃testinal tract. This article is intended to review recent researches on microbiome,common detection techniques and the relationship with hepatotoxicity induced by Polygonum multiflorum Thunb.,scutel⁃laria baicalensis that directly affects the intestinal tract,nephrotoxicity induced by Rhizoma Alismatis and pneumonia induced by Xiao-Chaihu-Tang.

  4. Studies on De Materia Medica of Dioscorides in the Islamic era

    Directory of Open Access Journals (Sweden)

    Vedat Yildirim, Rifat

    2013-06-01

    Full Text Available Pedanius Dioscorides was a Roman army surgeon in the first century A.D. His great work called De Materia Medica is widely accepted as the foremost pharmaceutical source of antiquity. Dioscorides was the originator of materia medica (pharmacology, and he took advantage of his extensive travels to study plants. Dioscorides was considered a major authority on simple drugs for sixteen centuries. De Materia Medica served as a corner stone for both western and eastern pharmaceutical and herbal writing, and was translated into Syriac, Arabic, and Persian, as well as Latin. The particular characteristic of medical therapy in the Medieval Period was the extensive employment of drugs of all kinds. For this reason, Dioscorides’ De Materia Medicawas not only studied closely, but it also became a text book that Turk-Islamic scientists frequently referred to in their writings.Pedanius Dioscórides fue médico cirujano en el ejército romano en el siglo I d.C. Su gran obra llamada De Materia Medica es conocida como la principal fuente de farmacopea de la antigüedad. Dioscórides fue el inventor de la materia medica, y aprovechó sus extensos viajes para dedicarse al estudio de las plantas. Dioscórides fue considerado una eminencia en el tema de las drogas de origen natural a lo largo de dieciséis siglos. De Materia Medica sirvió como piedra angular para los textos farmacéuticos y herbarios tanto en occidente como en oriente y fue traducida al siríaco, árabe y persa, además de al latín. La particular característica de la terapia médica en la época medieval fue el uso extensivo de todo tipo de drogas. Por esta razón, además de estudiarse minuciosamente, De Materia Medica de Dioscórides se convirtió también en un libro de texto al que frecuentemente hacían referencia los científicos turco-islámicos en sus escrituras.

  5. From Materia Medica to the Pharmacopoeia: Challenges of Writing the History of Drugs in India

    OpenAIRE

    Bhattacharya, Nandini

    2016-01-01

    Abstract Historians of indigenous medicine in colonial India have looked more closely at the changes, reinventions and reformulations of institutions of Ayurveda and Unani than at the cognitive content of the drugs themselves. The few historians who have examined the changing content of indigenous medicines have conceptualised the creation of materia medica of Indian drugs through two tropes: one of circulation (of specific drugs) through epistemological and geographic boundaries and the seco...

  6. Materia Socio Medica is Indexed in Pubmed and Archived in PubMed Central.

    Science.gov (United States)

    Masic, Izet

    2013-01-01

    Materia Socio Medica Journal has been accepted for archiving in PubMed Central from 2011. The journal started in 1993 as offi cial journal of Social Medicine Association of B&H. During last 3 years Mat Soc Med has included in almost all femous on-line databases (except WoS). All issues of Mat Soc Med published in 2012 are now visible on PubMed/PubMed Central.

  7. Investigation on Detection of Aflatoxins in Chinese Materia Medica and Pharmaceutical Intermediates Microbiological Contaminated by Immunoaffinity Column Clean-up Combined with Post-column Derivatization%免疫亲和柱净化HPLC柱后光化学衍生化法检测中药及染菌中药制剂中间体的黄曲霉毒素

    Institute of Scientific and Technical Information of China (English)

    胡一晨; 万丽; 范成杰; 吕维; 杨芳; 吉琅

    2012-01-01

    Objective; To establish a method to determine aflatoxins B,, B2, G1, G2 in Chinese Materia Medica and pharmaceutical intermediates microbiological contaminated by immunoaffinity column clean-up combined with post-column derivatization and HPLC-FD detection. Method: Using immunoaffinity column cleanup combined with post-column derivatization, the analytical method to detect aflatoxins B1 , B2, G,, G2 was established firstly, and then 14 kind of Chinese Materia Medica and pharmaceutical intermediates microbiological contaminated was detected respectively. Result: The method with the great linear concentration range of 0. 15-6.0 ng-mL-1 for aflatoxins G2, B2, and 0.5-20.0 ug·L-1'for G,, B, respectively, was stable and accurate. As a result, aflatoxins B,was detected in Chuanxiong Rhizoma and Platycladi Semen in the 14 kind of Chinese Materia Medica, while there were none of aflatoxins in the pharmaceutical intermediates made by Chuanxiong Rhizoma. Conclusion: The method established in this study was specific and accurate for the detection of aflatoxins in Chinese Materia Medica and pharmaceutical intermediates.%目的:采用免疫亲和柱净化,结合柱后光化学衍生化的高效液相色谱-荧光检测器建立同步检测常用中药材及染菌中药制剂中间体中的黄曲霉毒素B1,B2,G1,G2的方法.方法:采用免疫亲和柱净化洗脱结合柱后光化学衍生手段,建立黄曲霉毒素B1,B2,G1,G2的分析方法,并分别对14种中药材及染菌中药制剂中间体进行检测.结果:黄曲霉毒素B2和G2,B1和G1分别在0.15 ~ 6.0和0.5 ~20.0 ng·mL-1线性关系良好,方法准确稳定.所选的14种中药中川芎和柏子仁检测出黄曲霉毒素B1,而以染菌中药川芎所制备的5种提取物中均未检出黄曲霉毒素.结论:采用此方法检测常用中药材及其制剂中间体中的黄曲霉毒素无干扰性杂峰,结果准确可靠.

  8. Preparation technology for hydrogel cataplasm of Chinese materia medica in industrialization%中药水凝胶巴布剂产业化工艺技术攻关研究

    Institute of Scientific and Technical Information of China (English)

    李伟泽; 张光伟; 赵宁; 孔朋; 焦晓彪

    2012-01-01

    目的 通过对中药水凝胶巴布剂产业化过程中的技术难点进行攻关研究,为中药水凝胶巴布剂的产业化提供一种切实可行的制备工艺,以促进巴布剂的产业化发展.方法 采用设备满负荷规模生产中药水凝胶巴布剂,研究物料加入顺序、物料混合时间、静置条件(温度、湿度、时间)对于膏体涂布切割的难易程度和巴布剂的质量如凝胶强度、柔软性、黏性、残留、冷流与无纺布渗析等的影响规律;并通过3个不同的中药复方提取物进行验证.结果 保湿剂(甘油)加入真空搅拌器内,将骨架材料(聚丙烯酸钠)、填充剂(陶瓷粉)、交联剂(甘氨酸铝)、交联调节剂(EDTA)加入其中,在真空度-0.07MPa以下,搅拌5 min,得到甘油相;再将pH调节剂(柠檬酸)与皮肤增黏剂(聚维酮)的混合水溶液与中药提取物一次性加入到甘油相中,在真空度-0.07 MPa下,搅拌12 min,得到膏体:将膏体转移至涂布切割机上,进行涂布切割,得到半成品.将半成品置于湿度55%、温度30℃条件下,存放18h;再置于湿度75%、温度20℃条件下,存放12h,进行包装;包装后,置于阴凉处静置96 h,即可得到膏体柔软、黏性良好、膏面光洁平整且无渗析的中药水凝胶巴布剂.结论 本实验得到一种适合于中药水凝胶巴布剂产业化的制备工艺,将极大地促进中药水凝胶巴布剂的产业化进程.%To overcome the technological difficulty in the preparation of hydrogel cataplasm of Chinese materia medica (HCCMM) during the process of industrialization, and to provide a feasible preparation technology for HCCMM development of industrialization. Methods The experiment was carried out for the HCCMM scale production with the full-load equipment. The effects of the materials feeding order, mixing time, and static condition (temperature, humidity, and time) on the spreading and cutting of the paste and on the quality of cataplasm, such as gel

  9. Investigation on pattern and methods of quality control for Chinese materia medica based on Dao-di herbs and bioassay-bioassay for Coptis chinensis%基于道地药材和生物测定的中药质量控制模式与方法研究——黄连质量生物测定

    Institute of Scientific and Technical Information of China (English)

    鄢丹; 肖小河

    2011-01-01

    针对中药质量生物评价与控制中面临的重要技术问题--生物测定方法,以黄连质量生物评价与控制(抑菌活性)为代表性实例,从方法学内涵、选择原则、实验设计、数据分析等方面,对融合生物效价值和生物效应谱表征技术为一体的抑菌活性检测的新方法建立过程及应用进行阐释,以期为构建基于道地药材和生物测定的中药质量控制模式与方法提供技术参考.%Estaolishment of bioassay methods is the technical issues to be faced with in the bioassay of Chinese materia medica. Taking the bioassay of Coptis chinensis Franch as an example, the establishment process and application of the bioassay methods (including bio-potency and bio-activity fingerprint) were explained from the aspects of methodology, principle of selection, experimental design, method confirmation and data analysis. The common technologies were extracted and formed with the above aspects, so as to provide technical support for constructing pattern and method of the quality control for Chinese materia medica based on the Dao-di herbs and bioassay.

  10. [Preliminary investigation on the materia medica of the Zhuang ethnic group].

    Science.gov (United States)

    Rong, Xiao-Xiang; Li, Gui

    2013-09-01

    By Zhuang materia medica, it refers to application of medicines under the instructions of medical theory of Zhuang ethnic group. By studying the pronunciation of the Zhuang language for the terms "zhu yu", "bai jiu", and "mi gu" included in the shan hai jing nan shan jing (The Classic of Southern Mountain in Classic of Seas and Mountains) carried out by the Zhuang scholar Qin Bao-lin, it was concluded that the Zhuang minority already applied medicines early in the pre-Qin period. Through extensive cultural communication in different regions in the Wei-Jin-Southern-Northern Dynasties, the medicinal experiences of the Zhuang ethnic group appeared in ancient literature. The antidotes in Zhou hou fang (Handbook of Prescriptions for Emergency), for instance, were mostly coming from the Southern Ridge area. Since the Sui-Tang Dynasties, many materia medica recorded in the herbal works and regional gazetteers, and Annals such as the Guangxi Annals, Gazetteer of Nanning County, and Gazetteer of Liuzhou County, Gazetteer of Binzhou County etc., also carry medicines such as Cinnamom twigs and bark, and mangosteen etc., which are similar to those of the Zhuang medicines. In the Republican period, many manuscripts of Zhuang medicines appeared. After 1949, many institutions of Zhuang medicine were set up successively, including The Nanning Medical Institute, The Medical Institute of Wuzhou, The Medical Institute of Guilin. Systematic researches were also done, with publication of a series of works on Zhuang materia medica. Reformation of part of the prescription forms of Zhuang medicine were also accomplished.

  11. Identification of species and materia medica within Angelica L. (Umbelliferae) based on phylogeny inferred from DNA barcodes.

    Science.gov (United States)

    Yuan, Qing-Jun; Zhang, Bin; Jiang, Dan; Zhang, Wen-Jing; Lin, Tsai-Yun; Wang, Nian-He; Chiou, Shu-Jiau; Huang, Lu-Qi

    2015-03-01

    DNA barcodes have been increasingly used in authentication of medicinal plants, while their wide application in materia medica is limited in their accuracy due to incomplete sampling of species and absence of identification for materia medica. In this study, 95 leaf accessions of 23 species (including one variety) and materia medica of three Pharmacopoeia-recorded species of Angelica in China were collected to evaluate the effectiveness of four DNA barcodes (rbcL, matK, trnH-psbA and ITS). Our results showed that ITS provided the best discriminatory power by resolving 17 species as monophyletic lineages without shared alleles and exhibited the largest barcoding gap among the four single barcodes. The phylogenetic analysis of ITS showed that Levisticum officinale and Angelica sinensis were sister taxa, which indicates that L. officinale should be considered as a species of Angelica. The combination of ITS + rbcL + matK + trnH-psbA performed slight better discriminatory power than ITS, recovering 23 species without shared alleles and 19 species as monophyletic clades in ML tree. Authentication of materia medica using ITS revealed that the decoction pieces of A. sinensis and A. biserrata were partially adulterated with those of L. officinale, and the temperature around 80 °C processing A. dahurica decoction pieces obviously reduced the efficiency of PCR and sequencing. The examination of two cultivated varieties of A. dahurica from different localities indicated that the four DNA barcodes are inefficient for discriminating geographical authenticity of conspecific materia medica. This study provides an empirical paradigm in identification of medicinal plants and their materia medica using DNA barcodes.

  12. [Academic heritage of Jiu huang ben cao (Materia Medica for Relief of Famines) in Japan].

    Science.gov (United States)

    He, Huiling; Xiao, Yongzhi

    2014-11-01

    Jiu huang ben cao (Materia Medica for Relief of Famines) was the first monograph on famines herbal in the history of China, which creates a new research field of edible plants. Around the middle and late 17th century, Jiu huang ben cao was spread to Japan and aroused great attention of famous Japanese herbalists. Thus, all versions of different edition systems were circulated in Japan. Later, some famous Japanese scholar ssuccessively quoted texts of Jiu huang ben cao from the Nong zheng quan shu (Whole book on Agricultural Administration) spread in Japan, and block-printed it as an independent work. As a result, Jiu huang ben cao virtually circulated widely in Japan.

  13. From Materia Medica to the Pharmacopoeia: Challenges of Writing the History of Drugs in India.

    Science.gov (United States)

    Bhattacharya, Nandini

    2016-04-01

    Historians of indigenous medicine in colonial India have looked more closely at the changes, reinventions and reformulations of institutions of Ayurveda and Unani than at the cognitive content of the drugs themselves. The few historians who have examined the changing content of indigenous medicines have conceptualised the creation of materia medica of Indian drugs through two tropes: one of circulation (of specific drugs) through epistemological and geographic boundaries and the second, of marginalisation of certain other drugs either through a lack of textual legitimacy or the lack of the newly discovered 'active principles' within each drug. While these approaches have been useful, there is a case to be made for understanding the creation of formularies of Indian drugs in 19th and 20th centuries through the prism of medical praxis in India.

  14. Alshamel fi Sana’at Tebbi’at: A Comprehensive Book on the Materia Medica

    Science.gov (United States)

    Mosaffa-Jahromi, Maryam; Kiani, Hossein

    2016-01-01

    Background: Ala-al-din abu Al-Hassan Ali ibn Abi-Hazm al-Qarshi al-Dimashqi, known as Ibn al-Nafis (1210-1288 AD), was a Muslim Syrian physician primarily famous for being the first to describe the pulmonary circulation of the blood. The most voluminous of his books is Alshamel fi Sana’at tebbi’at, which is a comprehensive medical encyclopedia. It comprised 300 volumes of notes, from which only 80 volumes are published. His writings are cataloged in many libraries around the world. The aim of this review article, as a tribute to Ibn al-Nafis, was to introduce his valuable but neglected encyclopedia of Materia Medica. Methods: Ibn al-Nafis’ traditional approach in his “Alshamel fi Sana’at tebbi’at” book is studied in the present article. Results: Alshamel fi Sana’at tebbi’at covers three branches of knowledge. The first category is devoted to theoretical traditional medicine. The second is in four sections where much of it is not available yet. The third category is on Materia Medica covering the aspect of Unani medicine, from which only 28 volumes of the comprehensive book on the traditional medicine have been found so far. The latter, introduces mono-ingredient medications in alphabetical order. Each chapter, in several parts, is dedicated to the botanical characteristics and nature of each mono-ingredient medication. In addition, this book explains traditional pharmacokinetic of every single medication for each human body organs. Conclusion: Based on pharmaco-mechanistic perspective on Alshamel fi Sana’at tebbi’at, it could be considered as the main reference book on traditional medicine and pharmacy, worthy of revival. PMID:27516653

  15. Impacts of multicomponent environment on solubility of puerarin in biopharmaceutics classification system of Chinese materia medica%中药生物药剂学分类系统中多成分环境对葛根素溶解度的影响

    Institute of Scientific and Technical Information of China (English)

    侯成波; 汪国鹏; 张强; 杨文宁; 吕贝然; 隗丽; 董玲

    2014-01-01

    该研究针对中药生物药剂学分类系统(biopharmaceutics classification system of Chinese materia medica,CMMBCS)中的溶解度问题,实验考察人工制造的多成分环境对溶解度的影响,并利用所获数据进行数学建模总结相关规律.实验采用递进式设计,分别研究了单一成分背景(黄芩苷、小檗碱和甘草酸)、两成分背景(黄芩苷+甘草酸、黄芩苷+小檗碱和甘草酸+小檗碱)和三成分背景(黄芩苷+甘草酸+小檗碱)对葛根素溶解度影响的变化趋势,从而建立多成分环境对葛根素溶解度影响的数学回归模型方程.

  16. [Textual research on Costus root (Aucklandia lappa Decne) in the Sheng nong ben cao jing (Shennong's Classic of Materia Medica)].

    Science.gov (United States)

    Li, Guangyan; Wang, Dequn; Fang, Shiying; Xu, Maohong

    2014-05-01

    Aucklandia lappa Decne was first recorded in the Sheng nong ben cao jing (Shennong's Classic of Materia Medica). Through the textual research of herbal literature, it was found that the costus root in the Sheng nong ben cao jing perhaps was not the plant of Aucklandia lappa Decne of Compositae, but the eaglewood or Lignum Aquilasria Resinatum based on the comprehensive judgment of shape, taste, nature, and function etc. In the Sheng nong ben cao jing, it only includes costus root without the title of eaglewood, and Tao Hongjing recorded both herbs together in his Ming yi bie lu (Supplementary Records of Celebrated Physicians), which became a foreshadow of misunderstanding of the later generations. Beginning from the Tang ben cao (Materia Medica of the Tang Dynasty), the costus root was considered as the plant of Auckiandia lappa Decne from the Compostae with its profound influence until now.

  17. European Materia Medica in Historical Texts: Longevity of a Tradition and Implications for Future Use

    Science.gov (United States)

    De Vos, Paula

    2010-01-01

    Recent research in the area of new drug discovery has shown the continued promise of looking to natural products for bioactive compounds. Researchers have thus turned to traditional medicine, which is still used widely throughout the world and increasingly in industrialized countries as well, to provide clues as to which products to investigate. The oral traditions on which much of this medical knowledge rests, however, are unstable, prompting researchers to turn to textual sources for potential drugs. This study uses Mediterranean/European medical texts from the 5th century BC to the 19th century A.D. to compile a list of the most commonly used “simples” – or single action drug substances – used in therapeutics in traditional European medicine. It finds that traditional European materia medica was based on a Dioscordean tradition that lasted through the 19th century with remarkably little variation, but is significantly different from the present-day herbal pharmacopoeia as represented by the National Institutes of Health. The most prominent simples of that tradition can thus provide clues to further bioactive compounds that have not as of yet been fully exploited for their potential, but were clearly of great use in the past. PMID:20561577

  18. Progress of "cocktail" probe substrates approach and its application in studies of traditional Chinese materia medica on cytochrome P450 system%“cocktail"探针药物法及其在研究中药对细胞色素P450影响中的应用进展

    Institute of Scientific and Technical Information of China (English)

    候丛颂; 杨志宏; 孙晓波

    2013-01-01

    "Cocktail" probe substrates approach is a fast and high-speed method.It has been widely used to confirm drug metabolism pathways,evaluate drug-drug interactions,analyze drug metabolism phenotypes,optimize clinical drug programs and determine cytochrome P450 enzymes activity.This article reviewed characteristics of CYP450 enzymes,uniqueness of "cocktail" probe substrates,criteria for selection and the application to traditional Chinese materia medica to cytochrome P450 system.%“cocktail”(鸡尾酒)探针药物法作为一种快速、高通量的研究方法,目前已广泛应用于药物对细胞色素P450(CYP450)活性影响评估、药物代谢途径确认、药物-药物相互作用预测、药物代谢表型分析、临床用药方案优化等诸多研究方向.此方法具有独特的优势和广阔的应用前景.本文主要从CYP450同工酶的特性、“cocktail”探针药物法的特点、探针药物选择依据、“cocktail"探针药物法在中药对CYP450代谢酶影响中的应用进行综述.旨在较为系统地梳理相关研究进展,并为此方面的深入研究工作提供参考.

  19. 中药生物药剂学分类系统中多成分环境对葛根素渗透性的影响%Effect of multicomponent environment on intestinal permeability of puerarin in biopharmaceutics classification system of Chinese materia medica

    Institute of Scientific and Technical Information of China (English)

    刘洋; 王刚; 董玲; 唐明敏; 朱美玲; 董红环; 侯成波

    2014-01-01

    中药生物药剂学分类系统(biopharmaceutics classification system of Chinese materia medica,CMMBCS)中的渗透性评价,需多成分作为整体来开展研究,即使在研究具体某一成分时,也应将其放在多成分环境中审视.该实验以此为原则,将葛根芩连汤中的高含量成分作为多成分环境影响因素,考察葛根素的肠渗透性,运用在体肠单向灌流模型,对葛根素肠渗透性的相关参数进行测定,评价其他高含量成分对其肠渗透性的影响.实验结果表明不同比例的黄芩苷、甘草酸和小檗碱对葛根素的肠渗透性均有一定的影响,甘草酸能显著抑制葛根素的肠吸收,高浓度小檗碱会促进葛根素的吸收.该研究结果表明中药生物药剂学分类系统的渗透性评价充分考虑多成分环境中其他成分的影响是重要的研究思想.

  20. Term Selecting Research on Traditional Chinese Medicine and Related Disciplines for the Revision of Chinese Traditional Medicine and Materia Medica Subject Headings%《中国中医药学主题词表》中医药学及其相关学科类主题词修订选词研究

    Institute of Scientific and Technical Information of China (English)

    董燕; 刘静; 朱玲; 刘丽红; 李海燕

    2015-01-01

    Objective To confirm subject headings which are prepared to be added, deleted and modified in the class of traditional Chinese medicine and related disciplines (TG class) for the new edition of Chinese Traditional Medicine and Materia Medica Subject Headings (CTMMeSH). Methods Compiling principle, word frequency statistics and database retrieval results were considered. Other references, such as MeSH, were also used to help choose subject headings of TG class. Results In TG class, 35 subject headings were planned to be added, such as “medicine, traditional Korean”and“TCM constitution”;35 subject headings were planned to be deleted, such as“medicine, eastern tradition”and“meridians”;19 subject headings were planned to be modified, such as “four-constitution medicine” and “Minority Medicine”. The subject headings of “Minority Medicine”were unified to harmonize the problems of“TCM pharmacy”with other classes of subject terms. Conclusion Subject headings of TG class are chosen based on word frequency statistics. The word form are unified refer to regulation, teaching materials and documents, and should coordinate with subject headings of other classes.%目的:为新版《中国中医药学主题词表》(以下简称《词表》)的修订工作提供中医药学及其相关学科类(TG 类)拟新增、删除、修改的主题词。方法基于词表编制原则,根据词频统计和数据库检索结果,参考《医学主题词表》(MeSH)等相关资料,完成TG类主题词的修订。结果新版《词表》TG类主题词拟新增“医学,韩国传统”“中医体质类型”等35个主题词,拟删除“医学,东方传统”“经络带”等35个主题词,拟修改“四象医学”“民族医药学”等19个主题词。并统一“民族医药学”行文格式,协调“中医药学”与其他类主题词交叉的问题。结论 TG类主题词选词应基于词频统计,主题词的词形应规范描述

  1. [The Seongho () School's Study of the Ancient Learning () and Its Influence on the Debate about Materia Medica in the Late Joseon Dynasty].

    Science.gov (United States)

    Cho, Sung-San

    2015-08-01

    This study will determine the ways in which the ancient learning (gu xue, ) scholarship of the Seongho School, and its interest in the materia medica (ben cao xue, ) were related during the late Joseon period. The Seongho School centered its studies mainly on classical Chinese texts of the Han (206 BC-AD 220) and pre-Han (?-221 BC) (xian-qin lianghan, ) periods rather than those of the Tang and Song dynasties (618-1279). gu xue scholarship emerged during the Ming dynasty era (1368 -1644) as an alternative to the scholarly trends of the Song dynasty, which were dependent on Zhu Xi's (, 1130-1200) Neo-Confucianism and its interpretation of Han and pre-Han classical Chinese texts. This scholarly trend influenced Korean and Japanese literature, philosophy, and even medicine from the seventeenth through the nineteenth centuries. Focusing on Korean scholarship, we find a great deal of research regarding the influence of gu xue on Korean classical Chinese literature and Confucian philosophy in the late Joseon period; however, no study has examined how this style of scholarship influenced the field of medicine during the same period. This study will investigate how the intellectuals of the Seongho School, who did the most to develop gu xue among Joseon intellectuals, were influenced by this style of scholarship in their study of the materia medica. Jeong Yak-yong (1762-1836), the representative intellectual of the Seongho School, did not focus on complicated metaphysical medical theories, such as the Yin-Yang and Five Elements theory (yin yang wu xing shui, ) or the Five Movements and Six Atmospheres theory (wu yun liu qi shui, ). Instead, his interests lay in the exact diagnoses of diseases and meticulous herbal prescriptions which formed an essential part of the Treatise on Exogenous Febrile Disease (Shang han lun, ) written by Zhang Zhungjing (, 150-219) in the Han dynasty. The Treatise was compatible with the scholarly purpose of gu xue in that they both

  2. De materia medica versus codex alimentarius for the reinforcement of the gynecologic immune system: the case of endometriosis.

    Science.gov (United States)

    Vassiliadis, Simon

    2013-01-01

    Since the first Pharmacopoeia under the title "De Materia Medica," the importance of the utilization of plants and herbs has been an invaluable medicinal tool successfully employed for strengthening the immune system for combating a number of diseases in general, or assisting fertility and reproductive issues in particular. The beneficial use of herbal extracts, constituting the basis of modern medicines, is lately under the shadow of Codex Alimentarius that threatens, if not properly applied, serious immunity features rendering the host defenseless for intercepting harmful invaders, one of which is the mesenchymal endometriotic stem cell causing endometriosis.

  3. [Study on processing adjuvant medicines in Lei Gong's treatise on preparation and broiling of materia medica (Leigong Paozhi Lun)].

    Science.gov (United States)

    Zhang, Wei; Zhang, Ruixian

    2010-09-01

    There were 268 kinds of medicines recorded in the book of Lei Gong's Treatise on preparation and broiling of materia medica (Leigong Paozhi Lun). Among these medicines, 178 medicines were prepared with adjuvant medicines, including general and special compatible adjuvant medicines. These adjuvant medicines used in this book can be explained by the theory of "seven-relation compatibility". The author tried to explain the usage and their compatibility of these adjuvant medicines and put forward that attention should be paid to the changes in functions of medicines and the influences of society should be paid attention.

  4. 中药生物药剂学分类系统的多成分溶出评价方法在葛根芩连片中的应用%Application of multicomponent dissolution evaluation method of biopharmaceutics classification system of Chinese materia medica in Gegen Qinlian tablets

    Institute of Scientific and Technical Information of China (English)

    隗丽; 汪国鹏; 董玲; 唐明敏; 张雷; 朱美玲; 刘洋

    2014-01-01

    该研究是中药生物药剂学分类系统(biopharmaceutics classification system of Chinese materia medica,CMMBCS)用于中成药评价的实例,重点评估可能影响多成分吸收时序的溶出同步性问题.实验采用HPLC测定复方葛根芩连片中9种成分在不同溶出介质中不同时间点的累积溶出百分率,绘制体外溶出曲线,采用相似因子(f2)和聚类分析进行溶出曲线的相似性比较分析,结果表明在水介质中,峰7和峰8(黄芩苷)所代表的成分与2号参比峰(葛根素)相似性较差,相似因子均为43;在pH7.4介质中,峰7和峰8(黄芩苷)所代表的成分与2号参比峰(葛根素)相似性较差,相似因子分别为31和45;其他介质中各峰所代表的成分与2号参比峰(葛根素)均相似性较好.该实验表明峰3,4,5和6(小檗碱)所代表的成分与2号参比峰(葛根素)具有完全同步溶出的特性;峰1和峰9所代表的成分与2号参比峰(葛根素)具有基本完全同步溶出的特性;峰7和峰8(黄芩苷)所代表的成分与2号参比峰(葛根素)不具有同步溶出的特性.

  5. The Doctrine of Signatures, Materia Medica of Orchids, and the Contributions of Doctor - Orchidologists.

    Science.gov (United States)

    Pearn, John

    2012-12-01

    The heritage of medicine is written in many forms. One repository is to be found in the history of orchids, the world's largest family of flowering plants. Orchids were so named by Theophrastus (c.372-288 BC) who recorded their medicinal use as an aphrodisiac and the promoter of virility, in the context of the Doctrine of Signatures. Such use endured for millennia, and was recorded both by Paracelsus (1493-1551) and Linnaeus (1707-1778). The history of orchidology and medicine are entwined in four domains: (a) orchids and their historical materia medica, within the paradigm of the Doctrine of Signatures; (b) the enduring and extensive contemporary medicinal and culinary use of orchids such as Vanilla and salep extracts of Orchis; (c) the scientific contributions of doctors as orchidologists; and (d) the heritage of more than a hundred doctors' names in the scientific etymology of the Orchidaceae family. Prominent orchidologists have included the Scottish doctor-soldier and botanist, Robert Brown (1773-1858); the Director of the State Herbarium at Leyden and the Rijks Museum, Carl Ludwig Blume (1796-1862); and Dr William Sterling MD (1888-1967). Among the more than 1250 genus names (and 33,000 species) of orchids are the names of more than a hundred doctors, their lives and works perpetuated in the scientific etymology of this family of exotic, beautiful, flamboyant, intriguing and often expensive flowers. Generic names record the lives and works of such as Aristotle (384-322BC) in Aristotelia Loureiro 1790; Cadet de Gassicourt (1769-1821) in Cadetia Gaudichaud 1826; Sir Joseph Dalton Hooker (1817-1911) in Sirhookera O. Kuntze 1891; and Dr Theodore Daniel Vrydag Zynen (fl. 1820-1850) in Vrydagzynea Blume 1858. One of the principal horticultural genera of orchids, Brassavola, records the life and work of the Ferrara and Padua physician and botanist, Antonio Musa Brassavola (1500-1555). The first Slipper Orchid bred as a hybrid, Paphiopedilum harrisianum (by John

  6. [Classes of crude drugs and its distribution of producing area in the attached illustrations in Ben cao tu jing (Illustrated Classic of Materia Medica)].

    Science.gov (United States)

    Xu, T; Peng, H S

    2016-03-01

    Ben cao tu jing (Illustrated Classic of Materia Medica) is the earliest extant atlas book of materia medica in China, with 933 attached drawings. Among them, the largest portion, amounting to 670, are herbaceous plants, mostly commonly used, with definite marks of the origin producing areas, distributed across 149 administrative divisions(prefectures and counties) of the Song Dynasty, most of them in Northern area which were distributed denser than those in Southern area. The densest ones were located in Southern Shanxi, Eastern Sichuan and Eastern Anhui. In the attached drawings, the frequency of highest occurrence appeared in this Classic are three prefectures, Chuzhou, Shizhou and Guangzhou.

  7. Study on Modern Scientific Connotation of Bitter Taste Property of Chinese Materia Medica Based on Bitter Taste Receptors%基于苦味受体挖掘苦寒(味)中药药性的现代科学内涵*

    Institute of Scientific and Technical Information of China (English)

    戴丽; 霍海如; 隋峰; 姜廷良

    2015-01-01

    苦味受体属于G蛋白偶联受体,由25种亚型组成。苦味受体分布于口腔,介导哺乳动物的苦味觉;另外还存在于胃、肠管等口腔外消化系统,影响消化吸收及能量调控,在呼吸系统松弛呼吸道平滑肌,在心血管系统则发挥降压作用。而与现代苦味受体的最新进展惊人一致的,则是古老的中医药性味理论中的苦味中药或苦寒中药功效,如“泄”、“燥”、“坚”等特性,数千年来已广泛应用于消化、内分泌、呼吸、心血管等多系统疾病的治疗。因此,基于苦味受体环节,运用现代新技术、新方法,诠释中药苦味属性或苦寒药性的科学内涵,应是一条可行途径和新的研究模式,对于丰富和完善中药药性理论,促进中药的现代化和客观化具有重要作用。%Bitter taste receptors (BTRs) belong to the G protein-coupled receptors, which included 25 subtypes. BTRs, which were distributed in the oral cavity, mediated the bitter taste of mammalian. Furthermore, BTRs were also existed in the extra-oral digestive system such as the stomach and intestine to influence the digestion, absorption and energy regulation. It also can relax airway smooth muscles in the respiratory system and decrease blood pressure in the cardiovascular system. While being strikingly conformed to the latest advancements of BTRs, the efficacy of bitter taste property of Chinese materia medica (CMM) such as“excretion”,“dryness” and“strengthening” have been used in ancient theories of property and flavor in traditional Chinese medicine (TCM) for thousands of years in the treatment of multisystem diseases such as digestive, endocrine, respiratory and cardiovascular system. Therefore, applying modern techniques and new methods in the interpretation of the scientific connotation of bitter taste property of CMM based on BTRs should be a feasible way and a new research pattern. It played an important

  8. Thinking and primary practice on discovery of pharmacodynamic material basis of Chinese materia medica assisted by virtual screening method%虚拟筛选辅助揭示中药药效物质基础的思路与初步实践

    Institute of Scientific and Technical Information of China (English)

    杨文宇; 万德光; 杨鑫嵎

    2011-01-01

    基于多数常用中药的化学成分研究已很深入这一前提,尝试运用虚拟筛选方法辅助揭示中药药效物质基础,即把待研究中药所含的所有已确证结构的化学成分构建为分子库,与根据其功效而确定的各种靶点模型进行虚拟对接,筛选出理论活性成分后,再以药理实验数据进行验证,从而较全面地揭示代表相应功效的化学成分群.在初步的实践研究中,将由桑类中药510个化学成分构成的分子库分别与治疗消渴和利尿的靶点进行对接,结果显示:(1)对α-葡萄糖苷酶和碳酸酐酶Ⅻ有理论活性的成分分别远多于胰岛素受体和盐皮质激素受体;(2)部分化学成分对于α-舡葡萄糖苷酶的预测结果得到了文献实验数据的支持;(3)部分成分对多个靶点均显示较强的理论活性.虚拟筛选方法为阐释中药药效物质基础提供了新的视角和快捷途径.%Given in-depth study on the numerous chemical constituents from commonly used Chinese materia medica (CMM) whose pharmacodynamic material basis have not been completely clear yet, the tested virtual screening method has been used to reveal the pharmacodynamic material basis. It would be an unimaginable thing to experimentally evaluate the activity of every compound on all interrelated biomacromolecule targets one by one. In this study, the attempt of applying high-throughput virtual screening method to discover the therapeutically effective components, which represented corresponding active components in the given CMM, was developed. For the Chinese herb Sang (Morus alba) including Mori Folium, Mori Fructus, Mori Ramulus, and Mori Cortex, a molecular library consisted of their 510 known chemical components was docked with four target models related to antidiabetic and diuretic activity using Molegro software, respectively. It was shown that the numbers of components with theoretical activity on a-glucosidase and carbonic anhydrase XII were far

  9. [Study on carving workers of Chong xiu zheng he jing shi zheng lei bei yong ben cao (Revised Prepared Materia Medica Classified under Syndromes in Zhenghe Period) published by Huiming Xuan (Huiming Sanctum)].

    Science.gov (United States)

    Liang, Fei; Li, Jian; Zhang, Wei; Zhang, Rui-Xian

    2012-11-01

    The ancient carving workers have made a great contribution to the xylographic printing art in ancient China, so the studies on them are significant for a survey of ancient Chinese printing history, and for the identification of ancient Chinese books edition. Zheng lei ben cao published by Huiming Xuan (Huiming Sanctum) in the Jin and Yuan dynasties, which is the earliest extant edition of Zhenghe version system of Zheng lei ben cao and has important literature value. Thirty carving workers were involved in its printing process. On the whole, these workers had a relatively high technique and completed a remarkably fine work. In addition to lettering, 28 persons of them also made a total of 536 pages with 900 exquisite engraving illustrations on Chinese materia medica included in this book. Because of the high levels on carving, this precious book has been the representative of Pingshui edition, which has a great reputation but has very few works now.

  10. [Analysis of complexity in Chinese meteria medica industrial chain].

    Science.gov (United States)

    Liu, Ying; Li, Qi; Wang, Xiao-Fan

    2014-08-01

    Chinese meteria medica (CMM) chain is a long-span chain covering agriculture which mainly depends on the forces of nature as well as high-tech CMM industry, CMM expertise industry and fast developing CMM circulation industry. Imbalance among the development of these industries produces bottlenecks and hinders the operation of the entire production chain. After analyzing the structure of Chinese meteria medica industrial chain from the perspective of national economy industry, three industry classifications and differentiation of factor intensity, we conclude that the complex structure of CMM industry chain is attributable to these three aspects. And the complexity is mainly shown at complex industry, varied product types, different coordination of various industrial sections and different technical growth speed of varied industry. We propose that structural complexity is the natural property of the chain, which is the main reason of industry sector development imbalance and bottleneck. Results of this research could provide theoretical analysis for future research on the coordination of industrial chain and the efficiency of resource allocation.

  11. A theoretical and experimental study on the Fuzzy evaluation model of biological performance of Chinese materia medica with an either cold or hot herbal property%中药寒热药性表达模糊评价模式的理论与实验研究

    Institute of Scientific and Technical Information of China (English)

    金锐; 张冰; 刘小青; 薛春苗; 张倩; 李连珍; 赵茜; 李康

    2012-01-01

    OBJECTIVE: The concepts of cold and hot herbal properties in traditional Chinese medicine (TCM), reflecting the efficacy trends of medicinal herbs, have the Fuzzy characteristics. It is suited for the application of Fuzzy mathematics in research of herbal properties. For a comprehensive evaluation of herbal properties, this work constructed and made a practice of the Fuzzy discrimination model regarding the biological performance of Chinese materia medica.METHODS: Firstly, TCM formulas of cold or hot property were employed for setting the reference values and calculating the membership functions of cold and hot Fuzzy sets with Fisher discriminant. Then the model parameters of cold performance function (CPF) and hot performance function (HPF) were acquired. Second, the experimental data from studies on changes in multisystem indicators of animals given the classical cold formula (Sanhuang Fang) and hot formula (Jiangfugui Fang) were collected to calculate CPF and HPF. Then an experiment of administration of hot property herbs, Rougui (Cortex Cinnamomi) and Xianmao (Rhizoma Curculiginis), and cold property herbs, Huangbai (Cortex Phellodendri) and Zhizi (Fructus Gardeniae) to normal animals and animals with glucocorticoid-induced yang-deficiency or yin-deficiency state was designed. The relative changes in animal states were analyzed by the evaluation model to find the way in which herbal properties are represented.RESULTS: The HPF values of biological performance were higher than the CPF values in administration of Rougui to animals of normal (0. 528>0. 221), yang-deficiency (0. 203> -0. 490) and yin-deficiency (1.750 > -0.479) states, and in administration of Xianmao to animals of normal (0. 474> - 1. 601) and yang-deficiency (0. 288 > -1. 923) states, which represented the hot property. The HPF values of biological performance were lower than the CPF values in administration of Huangbai to animals of normal ( - 0. 870< 0.798) and yang-deficiency ( - 0.339<0. 194

  12. [Experience of treatment and understanding of impediment disease in Shen nong ben cao jing (Shen-ntonz's Classic of Materia Medica)].

    Science.gov (United States)

    Ding, Hongchang; Wang, Zhenrui

    2015-01-01

    As a book with significant historical materials for the research of impediment disease not to be ignored, Shen nong ben cao jing (Shennong's Classic of Materia Medica) contains, among its 365 kinds of materia medica, 75 kinds of medicines related to impediment disease. Among the latter ones, 51 are related to "damp impediment", "cold-damp impediment", "wind-cold-damp impediment", "wind impediment", "wind-damp impediment", and "cold impediment"; 16 are related to "laryngeal impediment", "general impediment", and "blood impediment"; 8 are related to "muscular impediment", "stomach impediment", "hernia-conglomeration impediment", "internal consumptive-thirst impediment", "wilting impediment", and "hemiplegic impediment". To systematically analyze the properties, tastes, and effects of these medicines and its related knowledge, and then further explore the overall recognition and their treating experience of the physicians at that period would not only enrich the historical research on impediment disease, but also offer much help and reference to the understanding and treatment of impediment for contemporary clinicians.

  13. The Establishment of Environmental Endocrine Disruptors Induced Precocious Puberty Macaca Fascicularis Model and the Intervention of Yin Nourishing Fire Purging Chinese Materia Medica%由环境内分泌干扰物引致食蟹猴性早熟疾病模型建立及滋阴泻火中药治疗干预的实验研究

    Institute of Scientific and Technical Information of China (English)

    朱琳; 蔡德培

    2012-01-01

    目的 建立灵长类--食蟹猴的由环境内分泌干扰物(environmental endocrine disruptors,EEDs)引致的性早熟疾病模型,验证滋阴泻火中药对EEDs拟雌激素活性的拮抗作用.方法 (1)不同月龄组青春前期雌性食蟹猴喂饲高、低剂量EEDs,通过观察EEDs拟雌激素作用,以确定最佳月龄、染毒剂量及染毒时间.(2)15只青春前期雌性食蟹猴随机分为染毒组、治疗组及对照组,每组5只.染毒组喂饲壬基酚(nonylphenol,4-NP)及双酚A(bisphenol,BPA),治疗组将染毒物质及滋阴泻火中药合剂同时喂饲,对照组喂饲溶剂玉米油.疗程4周.疗程完成时,检测血清雌激素水平、阴道脱落细胞成熟指数,取出子宫,测定其子宫湿重、子宫内膜及环形平滑肌厚度、子宫内膜上皮细胞及腺上皮细胞高度.结果 (1)20月龄为最佳染毒月龄,低剂量EEDs为最佳染毒剂量,4周为最佳染毒时间.(2)与对照组比较,染毒组血清雌激素水平明显升高,阴道脱落细胞成熟指数显著增加,子宫湿重、子宫内膜厚度及环形平滑肌厚度、子宫内膜上皮细胞及腺上皮细胞高度显著增加(P<0.05).与染毒组比较,治疗组上述指标均显著降低(P<0.05).结论 本研究成功地建立了灵长类--食蟹猴由EEDs引致性早熟的疾病模型,证实了EEDs具有显著的拟雌激素活性,并验证了滋阴泻火中药合剂对其拟雌激素活性具有显著的拮抗作用.%Objective To establish the environmental endocrine disruptors (EEDs) induced precocious puberty macaca fascicularis model, thus verifying the antagonism of yin nourishing fire purging Chinese materia medica (YNFPCMM) against the estrogenic effects. Methods (1) The female prepubescent monkeys at different months old were fed with high dose and low dose EEDs. By observing EEDs' estrogenic effects, the optimal age, the optimal exposure dose, and the optimal exposure time were determined. (2) Fifteen female prepubescent monkeys were

  14. Effects of Chinese Materia Medica Combined Chemotherapy on the Survivals of Stage Ⅱ and Ⅲ Colorectal Cancer%中医药联合化疗对大肠癌Ⅱ、Ⅲ期患者生存期的影响

    Institute of Scientific and Technical Information of China (English)

    吕仙梅; 郑坚; 朱莹杰; 顾缨

    2012-01-01

    Objective To study the effects of Chinese materia medica (CMM) combined chemotherapy on the recurrence, metastasis, and the disease free survival (DFS) of stage Ⅱ and Ⅲ colorectal cancer (CC) patients after radical cure. Methods Recruited were 366 inpatients and outpatients with stage Ⅱand Ⅲ colorectal cancer (CC) from Changhai Hospital, Second Military Medical University, and Tumor Department of Longhua Hospital, Shanghai University of Traditional Chinese Medicine from January 2002 to December 2008. A non-ran-domized concurrent control method was adopted. Patients were assigned to the combination group (treated by CMM + chemotherapy, 189 cases) and the chemotherapy group (177 cases) according to whether they were willing to receive the CMM treatment for more than 6 successive months. By using follow-ups at clinics, by letter, and by telephone, the DFS, 1-, 2-, 3-, and 5-year DFS ratios were observed. The correlations between DFS and the gender, age, tumor location, staging of clinical pathology, pathological type, chemotherapeutic cycle, radiotherapy, CMM treatment, end point event ( recurrence and metastasis) were analyzed. Results The recurrence or metastasis occurred in 145 cases (39. 61%) of the 366 patients. Of them, local recurrence occurred in 17 cases (11.72%), liver metastasis in 45 cases (31.03%), lung metastasis in 52 cases (35. 86%) ,and metastasis in other parts in 53 cases (36. 55%). Results of one-factor analysis showed six fac-tors such as the tumor location, pathological type, staging of clinical pathology, chemotherapeutic cycle, radio-therapy, and CMM treatment were correlated with the DFS, showing statistical difference (P<0. 01, P<0. 05).Results of multifactor analysis showed staging of clinical pathology, chemotherapeutic cycle, and CMM treatment were correlated with the DFS, showing statistical difference ( P<0. 01). Results of stratified study on the staging of clinical pathology indicated that the primary tumor location (P=0. 016

  15. Term Selecting Research on "Pharmaceutical Zoology and Botany" for the Revision of Chinese Traditional Medicine and Materia Medica Subject Headings%《中国中医药学主题词表》药用动植物学类主题词修订选词研究

    Institute of Scientific and Technical Information of China (English)

    朱玲; 刘静; 刘丽红; 董燕; 贾李蓉; 高博; 李海燕

    2015-01-01

    Objective To study term selecting principles and methods of subject terms in the class of"Pharmaceutical Zoology and Botany"for the new edition of TCM Materia Medica Subject Headings;To provide references for the revision.Methods Based on the compiling principles, word frequency of subject headings in TCM database were used as references. MeSH was referred to establish detail rules and regulations for revision of TB class.Results In TB class, 226 subject headings were planned to delete, such as "Apocynum Linn", "Piper betle Linn", "cetacean" and"dolphins";42 subject headings were planned to add, such as "Kalimerisindica", "Actinidiaceae" and "Squamata".Conclusion This revision formulated individual revision principles, proposed solutions for common problems, and basically completed adding and deleting of TB class and frame adjustment.%目的 研究《中国中医药学主题词表》药用动植物学类(TB类)主题词选词原则与方法,为其修订提供依据.方法 基于主题词表总体编制原则,以中国中医药数据库主题词标引词频为依据,参考医学主题词表(MeSH),确立TB类主题词修订细则.结果 本次修订拟删除罗布麻属、蒌叶胡椒、鲸目、海豚等226个主题词,拟增加马兰、猕猴桃科、有鳞目等42个主题词.结论 此次修订制定了药用动植物与中药类主题词结合考量等个性化修订原则,对常见问题提出了解决方案,基本完成原TB类主题词的增删及框架的调整.

  16. Advances of materia medica in adjusting Th1/Th2 cytokines balance%中药对Th1/Th2细胞因子平衡调节作用的研究进展

    Institute of Scientific and Technical Information of China (English)

    袁颖; 金素安; 何世民

    2011-01-01

    This paper reviews the regulating effects of materia medica on Th1/Th2 cytokine balance in autoimmune diseases, cancer, allergic diseases and different Chinese medicine syndromes.%概述中药对Th1/Th2平衡的调节作用,主要包括中药对自身免疫疾病Th1/Th2平衡的影响、对肿瘤Th1/Th2平衡的影响、对变态反应性疾病Th1/Th2平衡的影响以及对不同中医证型Th1/Th2平衡的影响等.

  17. Circulation and production of knowledge and scientific practices in southern America in the eighteenth century: an analysis of Materia medica misionera, a manuscript by Pedro Montenegro (1710).

    Science.gov (United States)

    Fleck, Eliane Cristina Deckmann; Poletto, Roberto

    2012-12-01

    The article analyzes a 1790 manuscript copy of Materia medica misionera, a book written in 1710 by a Jesuit, Pedro Montenegro. Alongside knowledge of a magical or religious nature, and exotic ingredients for the recipes, this work also contains the unmistakable presence of Hippocratic and Galenic conceptions and a growing empiricism, characteristic of the scientific transformations seen in the eighteenth century. The analysis of this work also prompts reflections about the diffusion, circulation and production of pharmacological and medical knowledge in the first half of the eighteenth century within the missions and colleges installed in the area that was the Jesuit Province of Paraguay, southern America.

  18. On the Natural Medical Features of Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    Zhu Ming; Gong Jiapei; Liu Yuanlong

    2007-01-01

    @@ Heaven-human-earth Pattern (HHE) regarded as a crucial conception of traditional Chinese medicine (TCM) has been applied extensively in TCM diagnostics, etiology, acupuncture therapeutics, materia medica and herbal formula, etc. It associates closely with Chinese classic cosmology.

  19. [Preliminary textual research on Zhijintang Sanctum re-revised version of Jinling edition of Ben cao gang mu (Compendium of Materia Medica)].

    Science.gov (United States)

    Zheng, Jinsheng

    2014-03-01

    The Zhijintang Sanctum version of the re-revised edition of Jinling edition of Ben cao gang mu (Compendium of Materia Medica)collected by Zhao Huiyuan of Baihe, Henan Province in 2008 was opted as one of the third batch of the National Directory of Rare Ancient Worksin 2010. On the second cover page (patent page), it is recorded as"Original Jiangxi version". However, it is investigated to find that most of its paper sheets were reprinted after the original Jinling version, only scores of paper sheets were supplemented block-printed, including the additional block-printed second preface and Li Jianyuan's submitted report of the Jiangxi version, the re-revised time of which should be after the Jiangxi edition, or 1603. The exact time can be determined only by checking it carefully against another Jinling re-revised version (the Sheyuantang Sanctum edition).

  20. Les gloses botaniques andalouses sur le manuscrit de Paris de la traduction arabe de la Materia Medica de Dioscorides

    Directory of Open Access Journals (Sweden)

    Ben Mrad, Ibrahim

    2009-12-01

    Full Text Available The following study focusses on a precious manuscript from the National Library in Paris, namely n.º 2849 of the Arabic manuscript collection. This is a manuscript of Andalusian origin of the Arabic translation of Materia Medica by Dioscorides, written in Syria at the beginning of the 13th century. Its margins are filled with glosses of synonymic nature, relating to the Greek terms of the plants described by the Greek pharmacologist and physician. These glosses, of Andalusian origin, offer a great terminological richness which is part of a large Arabic — mainly Andalusian — movement of revision and commentary of Materia Medica in Arabic. In the first part a general introduction to the manuscript is provided showing its significant value for a critical edition of the book, the glosses contained and, especially, of the Andalusian botanical glosses, insisting on their synonymic value and their terminological contribution. In a second part, a critical annotated edition of 44 glosses from the first maqāla of the book is proposed.

    Se aborda en este trabajo el estudio de un precioso manuscrito de la Biblioteca Nacional de París, el n.º 2849 de los fondos árabes. Se trata de un manuscrito de origen andalusí que contiene la traducción al árabe de la Materia Medica de Dioscórides, escrito en Siria a principios del siglo XIII, cuyos márgenes están repletos de glosas de naturaleza sinonímica, relativas a los nombres griegos que reciben las plantas descritas por la farmacología griega. Estas glosas son de orígen andalusí, y ofrecen una gran riqueza terminológica que se inscribe en un amplio movimiento árabe, y más concretamente andalusí, de revisión y comentario de la traducción árabe de la Materia Medica. En la primera parte de este estudio se ofrece una presentación general del manuscrito, mostrando su valor para una reedición crítica de la obra, de las glosas que contiene y

  1. Hartlaub & Trinks Pure Materia Medica: to save it or to lose it? La Materia Médica Pura de Hartlaub & Trinks: salvarla o perderla? A Matéria Médica Pura de Hartlaub & Trinks: salvá-la ou perdé-la?

    Directory of Open Access Journals (Sweden)

    Elias Carlos Zoby

    2003-01-01

    Full Text Available The Hartlaub’s & Trinks’ Materia Medica Pura (Reine Arzneimittellehre stands among few large collections of provings owned by the homeopaths. It has never been wholly translated to English, and perhaps to any other language. As a result, few people know and fewest have used it. However this materia medica was instrumental to make Hahnemann’s and Allen’s largest books. Any pathogenetic symptom is always a fact to which time only will add clearness and facility to understanding. Since it wasn’t translated, the homoeopathic repertories, written originally in English, don’t include a large part of its symptoms. Books that aren’t read and published tend to disappear and, in the case we are mentioning, a loss would be large to Homeopathy. The author compares the symptoms of materia medica and repertory. This research is made on original texts and afterwards compared to the translations. So he found, among the symptoms in Hartlaub & Trinks,many symptoms that aren’t in any other next, and connects it to some exemplary cases. Aspects that have been presented confirmed the importance of Hartlaub’s & Trinks’ Materia Medica Pura once it contains symptoms that are not presented in any other text, and correct those that were wrongly translated. The rescue stops being just a bibliophiler preciosity to show itself as a venture when one can find in its symptoms similarities with the patients. So Homeopathy presents itself in all its beauty and capacity of healing.

  2. 补肾疏肝中药联合针刺对体外受精-胚胎移植患者焦虑抑郁情绪及手术结局的影响%Effects of Acupuncture Combined Chinese Materia Medica for Tonifying Shen and Soothing Gan on the Anxiety and Depression of Patients with in vitro Fertilization and Embryo Transplantation and on the Treatment Outcomes

    Institute of Scientific and Technical Information of China (English)

    孙振高; 李婷婷; 连方; 张建伟; 郭琼; 孙金龙; 郭颖; 薛明玥; 张宁; 孟茜

    2012-01-01

    Objective To assess the effects of acupuncture combined Chinese materia medica for tonify-ing Shen and soothing Gan (CMMTSSG) on the anxiety and depression o1 patients with in vitro fertilization and embryo transplantation (IVF-ET), and to observe the treatment outcomes. Methods Totally 97 IVF-ET patients were randomly assigned to two groups, the acupuncture combined CMMTSSG (Group A, 51 cases) and the Western medicine treatment group (Group 3, 46 cases). The long protocol of iVF-ET in a mid tuteal phase was performed in all patients. Patients in Group A received acupuncture and CMMTSSG (Erzhi Tiangui Granule and Xiaoyao Granule) during the process of ovarian hyperstimulation, while those in Group B only received the rou-tines of IVF-ET. The improvement of Shen deficiency Gan depression syndrome (SDGDS) between alter and before treatment were observed in the two groups. The changes of self-rating anxiety scale (SAS) and Beck de-pression inventory (BDI) score were observed. The endometrial thickness, typing, and endometrial blood flow resistance index (Rl) on the day of injecting HCG, the number of retrieved oocytes, the rate of high quality oo-cytes, the fertilization rate, the rate of high quality embryos, and the clinical pregnancy rate were respectively compared between the two groups. Results The scores of SDGDS, SAS, and BDI were improved more obviously in Group A than in Group B, showing statistical difference (P0. 05). The proportion of type A en-dometrium was 74. 5% (38/51 cases) in Group A and 45. 7% (21/46 cases) in Group B, showing statistical differ-ence between the two groups (P0.05). The rate of high quality oocyte, the rate of high quality embryos, and the clinical pregnancy rate were all improved more significantly in Group A than in Group B, showing statistical difference between the two groups (P < 0. 05). Conclusions Acupuncture combined CM-MTSSG could obviously alleviate unfavorable emotions as anxiety and depression in patients with IVF

  3. Preliminary investigation on the materia medica of the Zhuang ethnic group%关于壮药的初步考察

    Institute of Scientific and Technical Information of China (English)

    容小翔; 李珪

    2013-01-01

    “壮药”是指在壮医理论指导下运用的药物.根据考古发现以及壮医学者覃保霖对《山海经·南山经》中“祝馀”、“白咎”、“迷谷”壮语发音的分析,可知在先秦时期,壮药即已存在.秦汉魏晋时期,随着区域间文化的广泛交流,壮族聚居地人民用药经验,在文献中不断体现,如《肘后方》中有关解毒药的记载,大多出自岭南.隋唐已降,本草文献和地方志中有不少记载与现今公认的壮药相似,如《广西通志》、《南宁府志》、《柳州府志》、《宾州志》等地方志中关于桂枝、肉桂、罗汉果等.民国时期,出现了不少有关壮药的手抄本.1949年之后,在党和政府的重视下,南宁医药研究所、梧州医药研究所、桂林医药研究所等机构相继成立,对壮医药进行系统的发掘整理,出版了一系列著作,还进行了部分壮药剂型的改革.%By Zhuang materia medica,it refers to application of medicines under the instructions of medical theory of Zhuang ethnic group.By studying the pronunciation of the Zhuang language for the terms "zhu yu"," bai jiu",and "mi gu" included in the shah hai jing nan shan jing (The Classic of Southern Mountain in Classic of Seas and Mountains) carried out by the Zhuang scholar Qin Bao-lin,it was concluded that the Zhuang minority already applied medicines early in the pre-Qin period.Through extensive cultural communication in different regions in the Wei-Jin-Southern-Northern Dynasties,the medicinal experiences of the Zhuang ethnic group appeared in ancient literature.The antidotes in Zhou hou fang (Handbook of Prescriptions for Emergency),for instance,were mostly coming from the Southern Ridge area.Since the Sui-Tang Dynasties,many materia medica recorded in the herbal works and regional gazetteers,and Annals such as the Guangxi Annals,Gazetteer of Nanning County,and Gazetteer of Liuzhou County,Gazetteer of Binzhou County etc.,also carry medicines such as

  4. 回药少尼子的本草考证%Research on Materia Medica of Hui Herbal Medicine ShaoNiZi

    Institute of Scientific and Technical Information of China (English)

    杨丽娟; 何婷; 高如宏

    2016-01-01

    According to the record in YanXingLu, prophet Mohammed said Hui medicine can cure many of disease. So we made a research on materia medica of Hui Herbal Medicine ShaoNiZi in Huihui prescriptions from several aspects, including Species research, historical records, origin, chemical composition, pharmacological ef-fects, traditional and modern medicine usage, and security as well, and found that it is the dry mature seed of the Ra-nunculaceae Nigella sativa L. Because of its wide therapeutic range, safety and non-toxic, it values to research.%《言行录》记载回药少尼子能够治疗许多疾病。因此本研究从品种考证、历史记载、产地、化学成分、药理作用、传统及现代医学用法、安全性等方面对《回回药方》中少尼子进行本草考证研究,确定其为毛茛科植物家黑种草 Nigella sativa L.的干燥成熟种子,其治疗范围极其广泛,且安全无毒,具有很大的研究价值。

  5. [Textual research on Guang dong xin yu (New Sayings of Guangdong) quoted in Ben cao gang mu shi yi (Supplements to Compendium of Materia Medica].

    Science.gov (United States)

    Zhang, Ruixian; Zhang, Wei; Li, Jian; Liang, Fei

    2014-05-01

    Altogether 15 terms for Guang dong xin yu (New Sayings of Guangdong) were used in Ben cao gang mu shi yi (Supplements to Compendium of Materia Medica), including Yue yu (Cantonese sayings), Chong yu (Sayings from Insect Drug), Jie yu (Sayings from Crustacean Drug), Xin yu (New Sayings), Yue hai xiang yu (Fragrant Sayings from Cantonese Region), Yue zhi mu yu (Sayings from Plants in Cantonese Annals), Guang dong suo yu (Trivial Sayings from Guangdong), Yue shan lu (Records of Cantonese Mountains), Yue lu (Cantonese Records), Jiao guang lu (Joint Guangdong Records), Yue cao zhi (Records of Cantonese Grasses), Guang guo lu (Records of Guangdong Fruits), Nan yue suo ji (Trivial Records of Southern Canton), Guang zhi (Guangdong Records), Yue zhi (Cantonese Records) etc. dealing with 57 sorts of drugs (with individual overlapping ones), the author of Xin yu was Qu Dajun, a surviving fogy of the Ming Dynasty actively involved in the activities to restore the old dynasty and resist the Qing Dynasty, and was persecuted in the literary inquisition in which his works were burnt so that Zhao Xuemin, when quoting his texts, had to go in a roundabout way.

  6. [Research practices of conversion efficiency of resources utilization model of castoff from Chinese material medica industrialization].

    Science.gov (United States)

    Duan, Jin-Ao; Su, Shu-Lan; Guo, Sheng; Liu, Pei; Qian, Da-Wei; Jiang, Shu; Zhu, Hua-Xu; Tang, Yu-Ping; Wu, Qi-Nan

    2013-12-01

    The industrialization chains and their products, which were formed from the process of the production of medicinal materials-prepared drug in pieces and deep processed product of Chinese material medica (CMM) resources, have generated large benefits of social and economic. However, The large of herb-medicine castoff of "non-medicinal parts" and "rejected materials" produced inevitably during the process of Chinese medicinal resources produce and process, and the residues, waste water and waste gas were produced during the manufactured and deep processed product of CMM. These lead to the waste of resources and environmental pollution. Our previous researches had proposed the "three utilization strategies" and "three types of resources models" of herb-medicine castoff according to the different physicochemical property of resources constitutes, resources potential and utility value of herb-medicine castoff. This article focus on the conversion efficiency of resources model and analysis the ways, technologies, practices, and application in herb-medicine cast off of the conversion efficiency of resources model based on the recycling economy theory of resources and thoughts of resources chemistry of CMM. These data may be promote and resolve the key problems limited the industrialization of Chinese material medica for long time and promote the realization of herb-medicine castoff resources utilization.

  7. 《救荒本草》在日本的传承%Academic heritage of Jiu huang ben cao (Materia Medica for Relief of Famines) in Japan

    Institute of Scientific and Technical Information of China (English)

    何慧玲; 肖永芝

    2014-01-01

    《救荒本草》是中国历史上第1部救荒类本草专著,开创了可食用植物研究的新领域.该书大约在17世纪中后叶传入日本,受到日本著名本草学家的重视,不同传本系统的版本都在日本流传.其后,一些日本名家先后从传到日本的《农政全书》中析出《救荒本草》的内容单独校刻刊行,使《救荒本草》在日本得以更广泛地流传.%Jiu huang ben cao (Materia Medica for Relief of Famines) was the first monograph on famines herbal in the history of China,which creates a new research field of edible plants.Around the middle and late 17th century,Jiu huang ben cao was spread to Japan and aroused great attention of famous Japanese herbalists.Thus,all versions of different edition systems were circulated in Japan.Later,some famous Japanese scholar ssuccessively quoted texts of Jiu huang ben cao from the Nong zheng quan shu (Whole book on Agricultural Administration) spread in Japan,and block-printed it as an independent work.As a result,Jiu huang ben cao virtually circulated widcly in Japan.

  8. Investigation on version and author of Zeng bu shi wu ben cao bei kao (Augmented Dietary Materia Medica for Investigation)%《增补食物本草备考》版本及作者考

    Institute of Scientific and Technical Information of China (English)

    郑洪; 廖春红

    2012-01-01

    Zeng bu shi wu ben cao bei kao,a masterpiece of Guangdong dietary materia medica works,has a variety of different versions.Based on our investigation on the existing versions,it is claimed that the statement in Zhong guo zhong yi gu ji zong mu (General Catalogues of Chinese Ancient Books),showing the first version of this book to be the version at the “renzi year of Emperor Yongzheng”,is wrong.We infer that the author of Zeng bu shi wu ben cao bei kao,HE Kejian and that of Sheng cao yao xing bei yao,HE Jian,is the same person.However,the former book is mainly a book on HE Ke-jian' s experiences sorted by HE Sheng-xuan on the basis of Shi wu ben cao hui zuan,and probably it maybe initially carved in 1738.%《增补食物本草备考》为广东食物本草类著作的代表作,现有多种版本存世,经考察,《中国中医古籍总目》著录该书最早版本为“雍正壬子”之说有误.此书署名作者何克谏与《生草药性备要》署名作者何谏为同一人.此书系何省轩整理何克谏经验,以《食物本草会纂》为蓝本辑编而成,可能初刻于1738年.

  9. 《证类本草》征引北宋邢昺《尔雅疏》考%Study on Classified materia medica Quoting from Er'ya Subcommentary by Xing Bing in Northern Song Dynasty

    Institute of Scientific and Technical Information of China (English)

    周云逸

    2015-01-01

    Classified materia medica,a masterpiece on herbs in Northern Song Dynasty,quotes abun-dantly from Er'ya Subcommentary to explain in detail of plants and herbs,which draws attention from re-searchers. Prior to the Song Dynasty,literatures on herbs seldom refer to critical interpretation of ancient texts- the two were much isolated. Emperors in the Song Dynasty valued the importance of medicine and hired of-ficers to compile literatures on herbs,and they started quoting from critical interpretation of ancient books. Er'ya Subcommentary also quoted from traditional literatures on materia medica,representing active interaction of herbalism and critical interpretation of ancient literatures.%北宋本草学巨著《证类本草》,大量征引北宋训诂学巨著《尔雅疏》中的相关文献以助本草名物训诂,这一现象值得深入研究。在宋代之前,本草文献绝少引用训诂文献,呈现出本草学与训诂学隔绝的形态。宋代皇帝重视医药,儒臣受命编修本草文献,遂开始重视引用传统训诂学的成果以助益药物辨名;同时《尔雅疏》也大量引用传统本草文献以助训诂,体现了宋代本草学与宋代训诂学良性的互动关系。

  10. Translation and Transliteration of Plant names in Ḥunayn b. Iḥsāq´s and Iṣṭifān b. Bāsil´s Arabic version of Dioscorides, De materia medica

    Directory of Open Access Journals (Sweden)

    Touwaide, Alain

    2009-12-01

    Full Text Available This paper deals with the Arabic translation of De materia medica by the Greek author Dioscorides (1st century A.D., particularly the rendering of plant names, which were sometimes properly translated and sometimes transliterated from the Greek. According to a traditional interpretation, the transliteration strategy was used by the translators when they did not know the exact Arabic equivalent of the plant names. I re-examine this interpretation here taking into account the role of plant names in the Greek text and the Andalusian works of botanical lexicography. As a result, I propose to interpret transliterations as a mean used by translators to keep visible the structure of the work, in which plant names played a certain role.

    Este artículo se ocupa de la traducción árabe del texto griego del tratado De materia medica de Dioscórides (siglo I, especialmente de los fitónimos que, en unos casos, fueron traducidos al árabe y, en otros, transliterados del griego. Según la interpretación tradicional, la transliteración era una estrategia utilizada por los traductores cuando no conocían el equivalente exacto árabe de los nombres de las plantas. Se propone en este trabajo una revisión de esta interpretación, teniendo en cuenta el importante papel que los nombres de las plantas desempeñan en el texto griego, así como en las obras de los lexicógrafos y botánicos andalusíes, llegando a la conclusión de que las transliteraciones eran una técnica utilizada por los traductores para mantener visible la estructura general de la obra de Dioscórides, basada en gran parte en la nomenclatura de las plantas.

  11. 《神农本草经》木香考%Textual research on Costus root (Aucklandia lappa Decne) in the Sheng nong ben cao jing (Shennong's Classic of Materia Medica)

    Institute of Scientific and Technical Information of China (English)

    李光燕; 王德群; 方士英; 徐茂红

    2014-01-01

    Aucklandia lappa Decne was first recorded in the Sheng nong ben cao jing (Shennong's Classic ofMateria Medica).Through the textual research of herbal literature,it was found that the costus root in the Sheng nong ben cao jing perhaps was not the plant of Aucklandia lappa Decne of Compositae,but the eaglewood or Lignum Aquilasria Resinatum based on the comprehensive judgment of shape,taste,nature,and function etc.In the Sheng nong ben cao jing,it only includes costus root without the title of eaglewood,and Tao Hongjing recorded both herbs together in his Ming yi bie lu (Supplementary Records of Celebrated Physicians),which became a foreshadow of misunderstanding of the later generations.Beginning from the Tang ben cao (Materia Medica of the Tang Dynasty),the costus root was considered as the plant of Auckiandia lappa Decne from the Compostae with its profound influence until now.%中药木香最早记载于《神农本草经》.通过考察多种本草文献,发现《神农本草经》中的木香可能不是现代菊科木香类植物,而是沉香,因为从形态、气味、功效等方面综合判断,沉香与《本神农草经》中的木香相吻合.《神农本草经》中只有“木香”,而无“沉香”,陶弘景将“木香”与“沉香”一并记载于《名医别录》中,为后人的误识埋下了伏笔.自《唐本草》始认为“木香”主要为菊科的木香类草本植物,这种认识一直影响至今.马兜铃科藤本青木香在《唐本草》和《本草图经》等本草著作的“木香”条中均有记载,但不做“木香”药用的主流.

  12. History of Chinese medicinal wine.

    Science.gov (United States)

    Xia, Xun-Li

    2013-07-01

    Chinese medicinal wine is one type of a favorable food-drug product invented by Chinese ancestors for treating and preventing diseases, promoting people's health and corporeity, and enriching people's restorative culture. In the course of development of the millenary-old Chinese civilization, Chinese medicinal wine has made incessant progress and evolution. In different historical periods, Chinese medicinal wine presented different characteristics in basic wine medical applications, prescriptions, etc. There are many medical and Materia Medica monographs which have systemically and specifically reported on Chinese medicinal wine in past Chinese dynasties. By studying leading medical documents, this article made an outline review on the invention, development, and characteristics of Chinese medicinal wine.

  13. [Contention on the theory of processing techniques of Chinese materia medica in the Ming-Qing period].

    Science.gov (United States)

    Chen, Bin; Jia, Tianzhu

    2015-03-01

    On the basis of the golden stage of development of processing techniques of medicinals in the Song dynasty, the theory and techniques of processing in the Ming-Qing dynasties developed and accomplished further. The knowledge of some physicians on the processing of common medicinal, such as Radix rehmannia and Radixophiopogonis, was questioned, with new idea of processing methods put forward and argued against those insisting traditional ones, marking the progress of the art of processing. By reviewing the contention of technical theory of medicinal processing in the Ming-Qing period, useful references can be provided for the inheritance and development of the traditional art of processing medicinals.

  14. Latest Progress in Tianjin Press of Chinese Herbal Medicines

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

    <正>Four journals including Chinese Traditional and Herbal Drugs (CTHD), Chinese Herbal Medicines (CHM), Drugs & Clinic (DC), and Drug Evaluation Research (DER) are edited and published by Tianjin Press of Chinese Herbal Medicines. CTHD was first published in 1970 and has been playing a great role for Chinese materia medica (CMM), especially in its present modernization. CTHD has successively won several honors in recent years, such as the 2nd State

  15. On the natural medical features of traditional Chinese medicine.

    Science.gov (United States)

    Zhu, Ming; Gong, Jiapei; Liu, Yuanlong

    2007-06-01

    Heaven-human-earth Pattern (HHE) regarded as a crucial conception of traditional Chinese medicine (TCM) has been applied extensively in TCM diagnostics, etiology, acupuncture therapeutics, materia medica and herbal formula, etc. It associates closely with Chinese classic cosmology. Since ancient time of China, many cosmic phenomena have been introduced to prove or illustrate TCM theories. Moreover, the five-element theory has been proven to be in keeping with some modern approaches of life provenance and life evolution. As a result, Chinese materia medica develops in a way of a pure natural medicine. It is of great significance that by realizing the natural features, the public nowadays can understand TCM better in its scientific connotations.

  16. A novel strategy for the discrimination of gelatinous Chinese medicines based on enzymatic digestion followed by nano-flow liquid chromatography in tandem with orbitrap mass spectrum detection

    OpenAIRE

    Yang H.; Shen YP; Xu Y.; Maqueda AS; Zheng J; Wu QN; Tam JP

    2015-01-01

    Huan Yang,1,2 Yuping Shen,1 Ying Xu,1 Aida Serra Maqueda,2 Jie Zheng,1 Qinan Wu,3 James P Tam21Department of Chinese Materia Medica and Pharmacy, School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu, People’s Republic of China; 2Division of Structural Biology and Biochemistry, School of Biological Sciences, College of Science, Nanyang Technological University, Singapore; 3Department of Chinese Medicine Authentication, School of Pharmacy, Nanjing University of Chinese Medicine,...

  17. Research progress on interaction of Chinese materia medica with intestinal flora%中药与肠道菌群相互作用的研究进展

    Institute of Scientific and Technical Information of China (English)

    陈秀琴; 黄小洁; 石达友; 郭世宁

    2014-01-01

    肠道菌群对人和动物的健康至关重要,具有多种生理功能,一旦菌群失调就会导致各种疾病.中药多数是以口服的形式进入消化道,因此肠道内的微生物对中药的代谢发挥着重要的作用;同时,许多中药对肠道菌群的平衡产生影响.从疾病与肠道菌群状态的关系,中药对肠道菌群的调节作用,肠道菌群对中药代谢的影响以及宏基因组学等研究方法进行综述,为研究中药与肠道菌群相互影响提供参考.

  18. Exploring the Correlation Between Fecal Microbiota Transplantation and Chinese Materia Medica Jinzhi%粪菌移植与中药金汁的相关性探究

    Institute of Scientific and Technical Information of China (English)

    甘丽; 岳仁宋

    2015-01-01

    粪菌移植是一种对难辨梭状芽孢杆菌感染、炎症性肠炎等消化道疾病有较为显著疗效的治疗方法.研究表明,在其他肠外疾病的治疗上也有较好的前景.现代粪菌移植理论与中医粪便入药有不谋而合之妙.中药金汁与粪菌移植的粪菌液制备方法极为相似,故查阅文献以探讨二者的相关性.中药金汁同粪菌移植的粪菌液实为同一药物,金汁与粪菌移植的粪菌液均是由人粪便用水等稀释液稀释后,经滤过而制成,只是在运用方式、储存上有所不同.

  19. 中医药治疗病毒性心肌炎临床研究进展%Clinica Research Progress of Chinese Materia Medica for Virus Cadiomyositis

    Institute of Scientific and Technical Information of China (English)

    韩丽华; 王振涛; 尚东丽

    2002-01-01

    @@ 病毒性心肌炎是临床常见病、多发病,近年来其发病率呈上升趋势.西医对本病无特效疗法[1],而祖国医学注重整体调节,辨证治疗,显示出对本病治疗的良好前景.现将近年来中医药临床研究概况综述如下.

  20. Application advances on zebra-fish model in study on Chinese materia medica%斑马鱼在中药研究中的应用进展

    Institute of Scientific and Technical Information of China (English)

    赵崇军; 田敬欢; 王金凤; 马志强; 曹丹; 夏青; 李丹; 张文婷; 姜岩

    2015-01-01

    斑马鱼作为一种模式动物,已经被广泛应用于遗传学和发育生物学研究.近些年,斑马鱼的研究已经拓展和延伸到中药领域.作为一种整体动物模型,斑马鱼能够全面地检测、评估中药的活性和毒性,进而实现高通量筛选.概括介绍了斑马鱼模型的特点及其在中药毒性、活性物质筛选和中药代谢方面的研究进展.

  1. Treating alzheimer ’s disease with chinese materia medica%中医药治疗阿尔茨海默病

    Institute of Scientific and Technical Information of China (English)

    李浪辉; 黎海珍; 覃金玲; 梁萧; 马程辉

    2014-01-01

    目的:观察中药益智康脑丸补肾益脾健脑生髓的方法治疗阿尔茨海默病,观察其临床治疗疗效及对人体的安全性。方法:采用区组随机、对照、非盲法观察。分组:共观察300例,治疗组与对照组按2:1比例进行区组随机分组。治疗组脑萎缩丸,口服,每次3丸,每日3次。对照组脑复康片[天津金世制药有限公司生产,津卫药准字(1995)第002686号],口服,每次3片,每日3次,疗程:4周,观察期间不用其它治疗本病药物。结果:治疗组临床疗效总有效率为82%;对照组临床疗效总有效率为83%。各种症状、体征治疗后,均有明显改善,P0.05,治疗组与对照组比较无显著性,提示脑萎缩丸对脾肾两虚证痴呆有较好的临床疗效,与对照药相似。结论:临床症状疗效结果表明,各种症状治疗后均有明显改善,提示脑萎缩丸可明显改善脾肾两虚证痴呆的临床症状,与对照药相似。%Objective:To observe the clinical effects and safety of treating Alzheimer's disease with the Intelligence-promoting and Brain-restoring Pill which tonifys the kidney, benefits the spleen, strengthens the brain and generates the marrow. Methods: Open randomized control trail. Grouping: 300 cases were observed in the treatment group and the control group in a 2:1 ratio block randomization. Patients in the treatment group orally took Cerebral Atrophy Pill, 3 pills each time, 3 times a day. The control group took Piracetam tablets [Tianjin Jinshi Pharmaceutical Co., Jin Medical Permitment (1995) No. 002686 No.] orally, 3 tablets each time, 3 times a day. Duration of treatment:4 weeks. During the observation period other medications were not allowed. Results:The clinical total effective rate was 82%;control group total effective rate was 83%. Variety of symptoms and signs after treatment showed significant improvement, P0.05 which was not significant. It suggests that Cerebral Atrophy Pill has better clinical efficacy on treating dementia caused by spleen and kidney deficiency, which is similar to the medicine of the control group. Conclusion:the clinical effect shows that a variety of symptoms were significantly improved after treatment. It suggests that cerebral atrophy pills can significantly improve the clinical symptoms of dementia caused by spleen and kidney deficiency, which is similar to the medicine of the control group.

  2. Dosage forms of Chinese materia medica with anti-hepatic fibrosis action%抗肝纤维化中药制剂的研究概况

    Institute of Scientific and Technical Information of China (English)

    李凤前; 胡晋红

    2004-01-01

    目的:综述抗肝纤维化中药制剂的研究,说明进行其新剂型研究的意义.方法:针对中药治疗肝纤维化及中药制剂的特点,分析并阐述抗肝纤维化中药的常规制剂、缓控释制剂和靶向给药系统.结果:抗肝纤维化中药剂型各具特点,目前大多为常规制剂,新剂型的研究较少.结论:治疗肝纤维化的中药新剂型和新制剂具有很大的研究应用价值.

  3. 白芍的中药代谢特征谱研究%Studies on metabolism of Chinese materia medica of radix from Paeonia lactiflora Pall

    Institute of Scientific and Technical Information of China (English)

    潘艳丽; 董玲; 刘洋; 石任兵; 徐暾海; 翟华强; 赵保胜; 方敏; 汪国鹏

    2011-01-01

    Objective To research the metabolism of components in the Radix of Paeonia lactiflora Pall. Methods (①) we established the HPLC fingerprint of water extract of Paeonia lactiflora Pall. and real-time monitored the chemical composition. (②) We established the HPLC fingerprint of rats' serum samples from hepatic portal vein, serum samples from aorta abdominalis and samples of intestinal absorption of Paeonia lactiflora Pall. (③) On this basis, using the established methods, I-IPLC fingerprint spectrum of serum samples,the sample of herb, the sample after intestinal metabolism, rats' serum samples from hepatic portal vein and rats'serum samples from aorta abdominalis were analyzed and compared in order to infer the metabolism of components in the Radix of Paeonia lactiflora Pall. Results 24 compositions were detected, seven of which were metabolized by intestinal flora and could not be absorbed into blood; six of them could not be absorbed directedly into intestinal; eight new compounds were absorbed into blood after bowel metabolism while they were not detected in water extract in Paeonia lactiflora Pall. Conclusion We could infer the metabolic processes of chemicals of Paeonia lactiflora Pall. in oral administration with this method.%目的 探讨芍药Paeonia lactiflora Pall.的干燥根中紫外可检出成分在大鼠体内的代谢过程。方法 ①运用HPLC-DAD技术,建立白芍水提物化学成分特征谱,进行其中总体化学成分的并行即时监测;②采用门静脉采血、腹主动脉采血、离体外翻肠囊法,建立白芍水提物入血成分、血中成分及肠吸收成分特征谱;③在相同色谱条件下,分析比较大鼠门静脉入血成分、腹主动脉血中成分及肠吸收成分的化学成分特征谱,推断白芍水提取物中化学成分的代谢过程。结果在分析的24种成分中,白芍中的6种成分不能被肠直接吸收:8种成分可被肠道直接吸收入血;7种成分被肠道直接吸收入血前已被肠内菌群代谢;血中出现的8种成分在白芍水提取物中未能查见,推测其为肠代谢转化后新生的成分吸收入血。结论 本实验可判定整体用药时白芍所含化学成分的代谢过程。

  4. Exploration of 3D Printer Models in Teaching Identification of Chinese Meteria Medica%《中药鉴定学》性状教学引入3D 纸模型构建技术初探

    Institute of Scientific and Technical Information of China (English)

    车苏容; 苏碧丽; 魏政熙; 文琛; 曾松

    2013-01-01

    The characteristics of Chinese meteria medica is an important part in teaching the course of Identification of Chinese Meteria Medica.It needs the real materials to display during teaching which would easily be damaged or rotten , and some of them are very ex-pensive.The development of 3D technology which owns the advantages of high quality with reasonable price and visual display can be a potential teaching method to change the traditional teaching way .%《中药鉴定学》性状教学的是直观形态教学为主的学科,教学用药材样本易变质受损,部分药材价格昂贵。3D纸模型技术的发展,物美价廉、表现力强,具有诸多优势,成为一个潜力具大的教学手段,引入本学科的教学将对传统教学模式带来改变。

  5. [Discussion on strengthening yin of chinese herbs with bitter-flavor clinical traditional Chinese pharmacology noun terminology standardization research].

    Science.gov (United States)

    Liu, Xiao-Mei; Bao; Zhaorigetu; Zhuang, Xin-Ying; Que, Ling; Tian, Chang-Jiang

    2013-10-01

    Clinical traditional Chinese pharmacology is the subject that study of basic theory of traditional Chinese medicine, property of Chinese materia medica and clinical application. The study on the standardization research of the terminology of clinical traditional Chinese pharmacology is an important premise and foundation to standardization, modernization and internationalization, informationization construction of clinical traditional Chinese pharmacology and is also the important content of the subject construction. To provide some exploring ideas for clinical traditional Chinese pharmacology noun terminology standardization, this article elaborates the concept of strengthening Yin with bitter-flavor herbs in several aspects, such as connotation and the historical origin, the clinical application in the traditional, modern clinic application, and the modern basic research and so on.

  6. Ubi Materia, Ibi Geometria

    Science.gov (United States)

    2000-09-29

    ideal on the other, caused probably certain tension for Kepler during his later studies. Primamn contrarietatem Aristoteles in metaphysicis recipit itlam...quam ex materia aut occasione materiae, aut uidi materia, tbi geometrra. Itaque quam Aristoteles dixit primam con trarietatem sine medio inter idem et... Aristoteles .7 For example, in his study of the snowflake (Strena seu de Nine sexangula ([10]) ,s Kepler searches the reason and cause for the sixfold

  7. Research on the teaching methods of Traditional Chinese Medicine Identification highlighting the practical ability%探讨突出实践能力培养高素质人才的《中药鉴定学》学科教学方法

    Institute of Scientific and Technical Information of China (English)

    王红霞; 陈随清; 谢新年; 郑岩

    2011-01-01

    Highlight the practical ability of high-quality personnel, according to the Characteristics of identificology of Chinese materia medica and the social need in 21st century, the intellectuals are educated with reasonal knowledge structure, colorful macroscopical identification experience, who is good at making use of microscopical identification and chemical identification and modern analysis instrument to estimate identificology of Chinese materia medica.The problems during the prcocedure of identificology of chinese materia medica are integrated analyzed and sloved.%突出实践能力培养高素质人才,结合中药鉴定学的特点及社会的专业需求,以培养知识结构合理、全面的中药鉴定人才,既具有丰富的性状鉴别经验,又具有熟练利用显微鉴定及理化鉴定知识并且熟练应用现代分析仪器鉴定中药,分析解决中药鉴定512作中各种问题的人才为目标,对中药鉴定学教学方法进行综合分析与探讨.

  8. [A complexity analysis of Chinese herbal property theory: the multiple formations of herbal property].

    Science.gov (United States)

    Jin, Rui; Zhang, Bing

    2012-11-01

    Chinese herbal property theory (CHPT) is the fundamental characteristic of Chinese materia medica different from modern medicines. It reflects the herbal properties associated with efficacy and formed the early framework of four properties and five flavors in Shennong's Classic of Materia Medica. After the supplement and improvement of CHPT in the past thousands of years, it has developed a theory system including four properties, five flavors, meridian entry, direction of medicinal actions (ascending, descending, floating and sinking) and toxicity. However, because of the influence of philosophy about yin-yang theory and five-phase theory and the difference of cognitive approach and historical background at different times, CHPT became complex. One of the complexity features was the multiple methods for determining herbal property, which might include the inference from herbal efficacy, the thought of Chinese Taoist School and witchcraft, the classification thinking according to manifestations, etc. Another complexity feature was the multiselection associations between herbal property and efficacy, which indicated that the same property could be inferred from different kinds of efficacy. This paper analyzed these complexity features and provided the importance of cognitive approaches and efficacy attributes corresponding to certain herbal property in the study of CHPT.

  9. 我国中药出口 SWOT分析与战略选择——基于胃药的调查%SWOT Analysis and strategic choice for exporting Chinese materia medica based on investigation of gastric medicine

    Institute of Scientific and Technical Information of China (English)

    张丽莉; 高文远; 张铁军; 郑纯林; 闫娟娟

    2007-01-01

    随着经济全球化和国外对中药的认可,国外生产的"洋中药"因科技含量高、产品符合国际标准,大举进入国际医药市场,给我国中药产业带来了巨大的冲击.以治疗胃病的中药为例,对我国中药出口的优势(strengths)、劣势(weakness)、机遇(opportunities)和威胁(threats)进行具体分析,提出了发展我国中药出口的品牌战略、合作和营销战略,以期为我国中药企业产品出口提供借鉴.

  10. Discussion on Interaction of Virus and Immunity in Research of Anti-HIV/AIDS Chinese Materia Medica%中药抗HIV/AIDS研究中病毒与免疫关系的探讨

    Institute of Scientific and Technical Information of China (English)

    吕岫华; 刘伟; 李泽琳; 曾毅

    2007-01-01

    从人体是一个有机整体以及病毒与机体这对特殊矛盾统一体的角度,探讨了中药在抗HIV/AIDS研究中病毒与免疫之间的相互关系,一方面为寻找新的药物作用靶点拓宽思路,另一方面也为研究中药抗HIV/AIDS的繁杂机制提供科学根据.

  11. Study on Usage of Interactive Four-methods on Teaching of Subject of Chinese Materia Medica%中药学教学中"四法联动"的运用体会

    Institute of Scientific and Technical Information of China (English)

    段卫华

    2016-01-01

    中药学课程是中医药相关本科专业的核心课程之一.针对中医药相关专业的培养特点,以中药学大纲为指导,紧紧围绕培养学生的中医药思维,提高灵活运用知识的能力等多面来考虑设计教学,采用"四法联动"的教学方法提高教学效果是非常有必要的.

  12. Interaction of intestinal microecology and internal metabolism of effective ingredients from Chinese materia medica%肠道微生态与中药有效成分代谢的相互作用

    Institute of Scientific and Technical Information of China (English)

    陶金华; 狄留庆; 单进军; 毕肖林; 赵晓莉

    2008-01-01

    肠道微生态与中药有效成分的代谢之间的研究已经被国内外许多学者所关注,对其研究已得到创新性进展.综述甘草、芦荟、番泻叶以及芍药等几种中药有效成分在肠道菌群影响下的代谢过程和机制,并阐述了中药对肠道微生态系统的平衡、调理等作用的研究现状.

  13. Advances in studies on the interaction of Chinese materia medica and chemical drug%传统中药与化学药物的相互作用研究进展

    Institute of Scientific and Technical Information of China (English)

    陈建; 贾晓斌; 范晨怡

    2008-01-01

    药物的相互作用(drug interaction,DI)是指药物受合用,或先后使用的其他药物、内源性化学物质等影响,使药效发生变化的现象。药物中的成分相互促进、拮抗和影响,发生下述改变:一是增强功效,单味药之间通过改变溶出率、进行水解转化或形成新的复合物等提高治疗效果,如生脉散中化学成分的变化有利于其抗心肌缺血作用,二是降低功效,

  14. Construction of Project for laboratory SOP of Traditional Chinese medicine and Materia Medica%中医药实验室规范化操作规程(SOP)工程建设

    Institute of Scientific and Technical Information of China (English)

    中医现代化科技发展战略研究课题组

    2002-01-01

    本文提出了中医药实验室规范化操作(SOP)工程建设的重要意义、目标和发展思路,其主要任务为:1.实验全过程的SOP管理;2.技术资料的SOP;3.实验技术的SOP;4.仪器设备操作的SOP.

  15. Good agricultural practice (GAP) of Chinese materia medica (CMM) for ten years: achievements, problems and proposals%中药材规范化生产(GAP)10年:成果、问题与建议

    Institute of Scientific and Technical Information of China (English)

    郭兰萍; 张燕; 朱寿东; 王桂华; 王秀; 张小波; 陈美兰; 何雅莉; 韩邦兴

    2014-01-01

    该文旨在总结中药材GAP实施过程中取得的成果,在分析其存在问题的基础上,就中药材GAP的进一步推行提出建议.作者认为中药材GAP推行10年取得了很大成果,包括①颁布了中药材GAP认证的一系列管理办法;②中药材规模化面积不断扩大;③农民及企业规范化种植中药材的意识增强;④形成了一批中药材GAP基地;⑤中药材栽培理论和方法不断完善;⑥培养了一大批中药材GAP生产及认证的专家和学者.GAP生产中存在的问题主要包括:①对GAP及其认证的认识和理解亟需深化;②GAP认证基地布局不够合理;③地缘经济及小农经济耕作是中药材规范化和规模化生产的瓶颈;④比较效益偏低限制了GAP的发展;⑤优良品种选育基础空白;⑥栽培技术不成熟导致生产过程风险较大;⑦土壤微生态恶化及连作障碍制约了中药材GAP基地的可持续发展.为进一步促进中药材GAP健康有序发展,作者提出以下建议:①改变生产模式,全面推动中药材GAP生产;②建立健全中药材标准体系,推行中药材优质优价;③充分考虑地缘经济文化,大力推行中药材定向培育;④强化基础研究和成果转化推广,为中药材生产提供技术保障;⑤深化对GAP的理解,大力推行生态种植和精细农业克服连作障碍.作者认为,虽然仍面临大量管理和技术问题,但中药材GAP早已深入人心,并展现出巨大的前景.未来时日,随着人们对GAP认识理解的不断加深,以及科技的巨大进步,GAP生产将会不断与精准农业、生态农业等现代农业理论、方法及技术融合,并展现出更大的潜力和更广阔的前景.

  16. Effect of Chinese Materia medica on the growth performance and egg quality of laying duck%中药制剂对蛋鸭生产性能及蛋品质的影响

    Institute of Scientific and Technical Information of China (English)

    张磊

    2011-01-01

    研究了中药制剂健胃增蛋散对蛋鸭生产性能及蛋品质的影响.结果表明:该中药制剂具有提高产蛋率,降低料蛋比和降低蛋黄胆固醇含量的作用:试验组与对照组相比,产蛋率明显提高、料蛋比显著降低(P<0.05),其中蛋鸭料蛋比由2.74下降到2.35,降低14.23%,蛋黄胆固醇南49.38 mmol/L下降到32.49 mmol/L,降低34.20%.

  17. Main point of experimental design of children population pharmacokinetics in Chinese materia medica%中药儿童群体药动学试验设计要点

    Institute of Scientific and Technical Information of China (English)

    倪天庆; 胡思源; 司端运; 钟成梁

    2013-01-01

    儿童由于身体发育尚未完善,药物在体内分布代谢有其自身的特点,且在不同年龄、体质量区间的差别很大,使得儿童用药剂量不能简单地参考成人用药剂量进行折算.群体药动学是研究目标人群药物代谢参数的有效方法,尤其适用于儿童这一特殊群体,可有效避免经典药物代谢取血点多所带来的伤害,并可充分了解协变量影响因素的大小,可见掌握药物在儿童中的群体典型值意义重大.提出了中药在儿童群体中开展药动学研究的试验要点与技术方法.

  18. ESWL联合中药治疗肾结石的临床疗效观察%Effect of combination treatment of ESWL and traditional Chinese materia medica on renal lithiasis

    Institute of Scientific and Technical Information of China (English)

    许思怡; 羊梅; 王素嫩

    2011-01-01

    目的:探讨治疗肾结石的有效方法.方法:将2007年12月~2009年9月将收治的170例泌尿系结石患者经体外冲击波碎石术(ESWL)后,随机分为观察组(90例)、对照组(80例).两组患者碎石后常规给予止血、消炎、解痉,西药治疗2 d,观察组同时服用自拟排石汤治疗,1月后观察两组疗效.结果:现察组90例,痊愈80例(88.9%),显效8例(8.9%),无效2例(2.2%),总有效率为97.8%.从服药到结石排净,时间最短者1 d,最长者13 d,平均7.3 d达到治愈目的.对照组80例,痊愈56例(70.0%),显效12例(15.0%),无效12例(15.0%),总有效率为85.0%.观察组的治愈率与总有效率明显优于对照组(P<0.05).结论:ESWL配合中药排石,可以有效提高临床疗效,促进碎石后结石的排净,减少复发且无明显毒副作用,值得临床推广.

  19. 全蝎炮制的研究概况%Research on Pathogenic Factors and Pathogenesis of Primary Dysmenorrhea and Progress in Its Treatment with TCM and Chinese Materia Medica

    Institute of Scientific and Technical Information of China (English)

    滕坤; 李超英; 张海丰

    2003-01-01

    @@ 全蝎又名全虫,为钳蝎科动物东亚钳蝎Buthus martensii karsch的干燥体.性味辛、平;有毒,具有熄风镇痉、攻毒散结、通络止痛的功效.用于小儿惊风、抽搐痉挛、中风口喎、半身不遂、破伤风、风湿顽痹、偏正头痛、疮疡、瘰疬等症[1].药用价值高,临床应用广泛,现对其炮制方法作一综述,为进一步研究奠定基础.

  20. HPLC测定中药成分溶度参数的理论与实验研究%Theoretical and experimental studies on solubility parameters of multiple components for traditional Chinese materia medica with HPLC

    Institute of Scientific and Technical Information of China (English)

    贺福元; 周宏灏; 罗杰英; 邓凯文; 扶瑾; 皮凤娟; 吴德智; 戴儒文

    2008-01-01

    目的:创立HPLC测定中药成分溶度参数的理论与方法.方法:运用色谱理论及Hildebrand-Scatehard溶解度理论创立HPLC法测定化合物的溶度参数的数学表达式,用已知溶度参数的咖啡因验证该理论并对大黄类成分进行测定.HPLC条件,色谱柱为Alltech Apoll C18柱(4.6 mm×250 mm,5μm);流动相为乙腈-水,梯度洗脱;检测波长咖啡因270 nm,大黄类成分254 nm;柱温25℃;进样体积10μL.结果:建立了保留时间与溶度参数关联的数学表达式,用此测得咖啡因的溶度参数为28.31 J1/2·cm-3/2,与文献28.84 J1/2·cm-3/2基本一致,用此法测得芦荟大黄素、大黄酸、大黄素、大黄素甲醚的溶度参数依次为39.70 J1/2·cm-3/2,39.08 J1/2·cm-3/2,38.37 J1/2·cm-3/2,36.42 J1/2·cm-3/2.结论:HPLC法能同时测定多个成分的溶度参数,这为研究中药的配伍溶解规律,单味中药剂改工艺研究奠定理论基础.

  1. 第四次全国中药资源普查试点外业调查情况简报%Field Investigation Progress in the Fourth National Survey of Chinese Materia Medica Resources

    Institute of Scientific and Technical Information of China (English)

    黄璐琦; 陆建伟; 郭兰萍; 孙丽英; 张本刚; 张小波; 赵润怀

    2013-01-01

    第四次全国中药资源普查试点工作从2009年开始筹备,2011~2012年先后分3批在全国22个省(区、市)启动了655个县的中药资源普查试点.共有8 000多名来自不同学科的专业技术人员组成普查队,按照全国统一普查技术规范和进度要求,开展了广泛深入的外业实地调查,获得了大量普查基础数据.前期启动的10个省(区、市)已完成70%以上的普查试点任务.据统计,截至到2013年5月底,全国中药资源普查数据库收集到资源调查样方套3万个,涉及药用物种9 000种,其中普查重点品种429种,采集标本47 665份、药材样品2 944份,拍摄药用植物形态及生态照片54万张,收集民间和民族传统医药知识500条.

  2. 中药固体制剂吸湿性评价及其实践应用%Hygroscopic Evaluation and its Practical Application of Solid Preparation of Chinese Materia Medica

    Institute of Scientific and Technical Information of China (English)

    耿炤; 王伟

    2013-01-01

    从产品质量设计的角度,在文献综述及理论计算的基础上,以达到控制水分上限的平衡吸湿量对应的相对湿度,作为关键相对湿度(KRH)较临界相对湿度(CRH)更有实际意义;可通过计算明确相关的工艺操作时限、相关变更的有效性,以及内包装材料防潮性能要求;此外,目前药品内包装材料的防潮性能指标低,应制订相应的内控标准。%On the basis of QBD ,literature review and theoretical calculations ,hygroscopic was evaluated by absorbent balanced ;within defining indicators ,process control and storage parameters were calculated ;packaging material was then chosen .Relative humidity while preparation reached moisture equilibrium at the maximum water standard ,is called key relative humidity (KRH) ,which is more practical significance than CRH ;time limit of process operation ,effectiveness of changes and packaging material moisture-proof per-formance requirements can be calculated ;current standards of moisture-proof performance indicators of phar-maceutical packaging materials should be developed appropriate ,and internal control standards should be given .

  3. Materia strana romanzo scientifico

    CERN Document Server

    Gómez Cadenas, Juan José

    2012-01-01

    Nel Laboratorio europeo per la fisica delle particelle, il CERN di Ginevra, sta per vedere la luce uno dei più grandi progressi scientifici di tutti i tempi: la scoperta di un nuovo stato della materia, il cosiddetto "plasma di quark". La direttrice del CERN, Helena Le Guin, teme però che insieme al plasma si stiano formando grumi letali di materia strana, in grado di scatenare una reazione a catena che potrebbe distruggere l'intero pianeta. Mentre Helena cerca disperatamente di far fronte alla crisi, a Ginevra arrivano Irene de Ávila, una giovane e promettente fisica teorica, e il maggiore Héctor Espinosa, un militare americano assegnato alla sede dell'ONU per lavorare a un progetto ultrasegreto legato alla non proliferazione delle armi nucleari: inizia così un'appassionante vicenda in cui convergono rivalità scientifiche, peripezie personali e rischiose operazioni di spionaggio che porteranno i protagonisti fino in Iran.

  4. Brief Analysis of Teaching Model for the Processing of Chinese Materia in Our School%我校《中药炮制学》教学模式浅析

    Institute of Scientific and Technical Information of China (English)

    王艳; 窦志英; 王晖; 刘亚男; 李佳玮; 马琳

    2016-01-01

    目的:对我校《中药炮制学》理论教学和实验教学的运行情况进行总结,为《中药炮制学》教学模式的改革提供参考和借鉴.方法:采用教学软件、教学视频等现代化教学方法和手段丰富理论教学内容;运用理论联系实际的教学方法,激发学生学习兴趣;在教学中引入科研成果,培养学生科研思维.改变了实验教学以传统验证性实验为主的教学模式,增加了设计性实验的学时和分值;改变了传统的平时成绩评价方法,采用形成性评价方法进行评价.结果:学生在学习过程中既学会了理论知识,又培养了分析问题和解决问题的能力,变被动学习为主动学习,从而取得了满意的教学效果.结论:《中药炮制学》教学应转变传统观念,注重科研与教学相结合;提高设计性实验在实验教学中的地位,以激发学生的学习兴趣,增强学生的实践能力,提高教学质量.%OBJECTIVE:Tosum up the condition of theoretical teaching and experimental teaching of the Processing of Chinese Materia,and to provide referencefor the reform of teaching model of the Processing of Chinese Materia. METHODS:Teaching soft-ware,teaching video and other modelrn teaching methods were used to enrich the content in theory teaching;linking theory with practice was used to stimulate students'interest in learning;scientific research achievement was introduced in teaching to train stu-dents' scientific research thinking;the teaching model of traditional confirmative experiment teaching was reformed by increasing de-signing experiment hours and score;the traditional usual performance evaluation method was changed by replacing with evaluation method of formative,and it was used for evaluation. RESULTS:The students not only learned theoretical knowledge,but also cul-tivated their ability to analyze and solve problems,changing from passive learning to active learning,so that it has made satisfacto-ry teaching effect

  5. IMAGINARIO, MATERIA Y SIMBOLISMO

    OpenAIRE

    Garagalza Arrizabalaga, Luis José; Facultad de Filología de la Universidad del País Vasco (Vitoria, España).

    2012-01-01

    Presentamos en este artículo la obra de dos autores que han tomado enserio la potencia de la imaginación como capacidad constitutiva del serhumano y de su realidad social. Se trata de G. Santayana y de CorneliusCastoriadis, que desde tradiciones diversas coinciden en su revalorizaciónde la potencia creadora de la imaginación, que es puesta en conexión através de la “psique” con el esencial dinamismo de la materia, así como ensu irónico escepticismo en lo relativo al fundamento de los valoresd...

  6. [Melatonina: old molecule, new medicament].

    Science.gov (United States)

    Fernández-Tresguerres Hernández, Jesús A

    2008-01-01

    Melatonin is a hormone with indolaminic structure, produced in the pineal gland during darkness, with chronobiological activity that has been known for decades. It is a physiological inducer of sleep and for this indication has been developed as a drug since many years in many international pharmaceutical markets. It has also a relevant antinflammatory and antioxydant capacity that results in beneficial actions on the liver, on cardiovascular diseases, inflammatory processes, in osteoporosis and also in certain tumours. Its neuroprotective action gives founded expectancies of having potential positive effects in several neurodegenerative diseases like parkinson or Alzheimer. It has been recently approved as a drug in the European Medicament Agency (EMEA) and the Spanish Medicament Agency as well. Some of its more relevant pharmacological actions are reviewed.

  7. Traditional Chinese medicine for treatment of liver diseases:progress, challenges and opportunities

    Institute of Scientific and Technical Information of China (English)

    Chang-qing Zhao; Yang Zhou; Jian Ping; Lie-ming Xu

    2014-01-01

    Traditional Chinese medicine (TCM) is commonly used in treating liver diseases worldwide, especially in China. The advantages of using TCM for treatment of liver diseases include: protecting hepatocytes, inhibiting hepatic inlfammation and antiifbrosis in the liver. In this article, we introduce TCM herbal preparations from the Chinese materia medica (such as Fuzheng Huayu) that are typically used for the treatment of liver diseases. Literature surrounding the mechanisms of TCM therapy for treatment of liver diseases is presented and discussed. We propose that side effects of herbal compounds are often under-appreciated, and that more care should be taken in the prescription of potentially hepatotoxic medicines. Further, to deepen the understanding of TCM mechanisms, new techniques and methodologies must be developed. Future studies will lead to the enhancement of clinical outcomes of TCM. As complementary and alternative therapies, TCMs will play an expanding role in the future of liver disease treatment.

  8. [Study on characteristics of pharmacological effects of traditional Chinese medicines distributing along stomach meridian based on medicinal property combination].

    Science.gov (United States)

    Zhang, Bai-Xia; Gu, Hao; Guo, Hong-Ling; Ma, Li; Wang, Yun; Qiao, Yan-Jiang

    2014-07-01

    At present, studies on traditional Chinese medicine (TCM) properties are mostly restricted to a single or two kinds of medicinal properties, but deviated from the holism of the theoretical system of TCMs. In this paper, the characteristics of pharmacological effects of different property combinations of TCMs distributing in the stomach meridian were take as the study objective. The data of properties of TCMs distributing in the stomach meridian was collected from the Pharmacopoeia of the People's Republic of China (2005). The data of pharmacological effects of TCMs distributing in the stomach meridian was collected from all of literatures recorded in Chinese Journal Full-text Database (CNKI) since 1980, Science of Chinese Materia Medica (Yan Zhenghua, People's Medical Publishing House, 2006) and Clinical Science of Chinese Materia Medica (Gao Xuemin, Zhong Gansheng, Hebei Science and Technology Publishing House, 2005). The corresponding pharmacological effects of property combinations of TCMs distributing in the stomach meridian was mined by the method of association rules. The results of the association rules were consistent with the empirical knowledge, and showed that different medicinal property combinations had respective pharmacological characteristics, including differences and similarities in pharmacological effects of different medicinal property combinations. Medicinal property combinations with identical four properties or five tastes showed similar pharmacological effects; whereas medicinal property combinations with different four properties or five tastes showed differentiated pharmacological effects. However, medicinal property combinations with different four properties or five tastes could also show similar pharmacological effects. In this study, the medicinal property theory and the pharmacological effects of TCMs were combined to reveal the main characteristics and regularity of pharmacological effects of TCMs distributing in the stomach meridian

  9. Investigation on Food as Materia Medica Collected%《食品集》考辨

    Institute of Scientific and Technical Information of China (English)

    史献浩

    2014-01-01

    在明代中叶大量的养生著作中,吴江县医学训科吴禄的《食品集》是一部较有代表性的食疗医书.他以《食物本草》和《饮膳正要》为蓝本,根据自身医学实践的经验进行增删改定,指导吴中百姓日常生活中的安全饮食、健康养生.

  10. [Irrigants and intracanal medicaments in endodontics].

    Science.gov (United States)

    Zehnder, Matthias; Lehnert, Birgit; Schönenberger, Kathrin; Waltimo, Tuomas

    2003-01-01

    Modern, biologic root canal therapy should be performed with suitable irrigating solutions and intracanal medicaments. The goal of endodontic treatment is to free the treated tooth from infection and prevent reinfection as thoroughly as possible by means which do not put the organism at risk. In this review of the literature, an evidence-based concept for irrigation and medication of root canal systems is presented. Irrigants and medicaments are discussed with respect to their antimicrobial, tissue-dissolving and endotoxin-decontaminating capacity in relation to their systemic toxicity. Recent findings pertaining to interactions of root canal medicaments and irrigating solutions and their impact on a sound irrigating and medicating concept are discussed.

  11. 基因测序技术在中药质量研究中的应用(Ⅱ)——山药基原的DNA测序鉴别%Application of gene technology in quality control of Chinese materia medica Ⅱ.Identification of Chinese Rhizoma Dioscoreae by DNA sequencing

    Institute of Scientific and Technical Information of China (English)

    刘玉萍; 何报作; 曹晖

    2001-01-01

    目的分析正品山药Dioscorea polystachya Turcz.与地方习用品广山药D.persimilis Prain et Burkill、土山药D.japaonica Thunb.和方山药D.alata L.的核基因组18S rRNA基因序列,为山药基原鉴别及品质评价提供分子依据.方法采用PCR直接测序技术测定山药及其地方习用品的18S rRNA基因核苷酸序列并作序列同源性分析.结果山药、广山药和土山药的18S rRNA序列长度均为1 810 bp,而方山药为1 807 bp.根据排序比较,广山药与正品山药的18S rRNA序列完全相同,而与土山药和方山药的序列同源性分别为99.89%和97.51%.结论 DNA测序技术可成为山药基原鉴定准确而有效的分子方法.

  12. Challenges in Research and Development of Traditional Chinese Medicines

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    This review is briefly to recall the history of research and development (R&D) of Chinese materia medica (CMM) and to discuss the challenges of Chinese traditional and herbal medicines (CTHM) facing the modern science and technology. The R&D of CTHM is thought to be an important pathway for new drug discovery. Since1949, about 140 approved new drugs have been developed, among which about 80 originated directly or indirectly from medicinal plants. CTHM has gained interest from the international medical, biomedical, and pharmaceutical institutions as a valuable source of potential medicines. For the modernization of CMM and innovative research of CTHM, there are following challenges to be faced: (1) to evaluate the efficacy, pharmacological properties, action mechanism, and active chemical constituents; (2) to develop new methodologies for the quality and safety of CTHM; (3) to apply new "-omics" techniques to accelerate drug discoveries developed from CTHM; and (4) to apply international practices including good agricultural practice, good manufacturing practice, good laboratory practice, and good clinical practice in the R&D of CTHM.

  13. New Collection of Crude Drugs in Chinese Pharmacopoeia 2010 Ⅱ.Sankezhen (Berberis spp.)

    Institute of Scientific and Technical Information of China (English)

    DAN Yang; LIU Yan-ze; PENG Yong; QIAN Zhong-zhi; XIAO Pei-gen

    2011-01-01

    Sankezhen (Berberidis Radix) is a traditional Chinese materia medica,cold in nature and bitter in taste,for treating syndromes of liver,stomach,and large intestinal meridians,in which berberine and berbamine are the major pharmacological components.Sankezhen has been readmitted in Chinese Pharmacopoeia 2010 following the 1977 version as the roots of Berberis spp.e.g.B.soulieana,B.wilsonae,B.poiretii,B.vernae,etc.Recent studies showed that Berberis spp.were potential phytomedicines with multiple spectrums therapeutic effects and various pharmaceutical parts.Here we reviewed Sankezhen in traditional use and phytochemistry,and its major active components berberine and berbamine with potential bioactivities recently discovered,such as antitumor,antidiabetic,antihyperlipidemic,anti-arrhythmic,and neuro-protective activities.It is necessary to mature the quality assessment of Sankezhen as a new admission of Chinese Pharmacopoeia 2010.Other parts of Berberis spp.should be investigated to better develop this herb in medicinal usage.

  14. 药物潜在毒性发现技术及其在中药安全性评价中的应用展望%Research progress on discovery of drug potential toxicity and perspective on safety evaluation of Chinese materia medica

    Institute of Scientific and Technical Information of China (English)

    边育红; 庄朋伟; 王丽; 周慧芳; 张艳军

    2011-01-01

    随着科学技术的不断发展,人类发现新化合物的种类和数量不断增加,但这些化合物最终成为药品到上市销售是一个周期长、操作复杂、资金投入大且失败率很高的过程.因此,寻找能够确切、快速、敏感反映外源性化合物对生物体毒性作用的安全性评价模型已成为现代药学研究的热点.近年来不断涌现出应用各种先进的生物学手段及平台进行药物毒性评价的方法,这些方法在一定程度上克服了传统毒理学药物毒性评价的缺点,不仅为药物安全性评价及应用奠定了基础,同时也节约了大量的人力、物力和财力.就药物毒性预测及潜在毒性评价方法进行综述,并对其在中药安全性评价方面的应用前景进行展望.%Following the development of science and technology, the number and variety of newly discovered compounds are increasing. However, it is a long process for the new compounds to become clinic medicines into the market eventually as well as be costly and difficult to manipulate with high failure rate. So it has been a hot point of modern pharmacy to set up a precise, fast, and sensitive model to evaluate the toxic effect of exogenous compounds on bio-organism. In recent years, large members of advanced biological methods and platforms for evaluating the drug toxicity have been put into use constantly. These methods not only overcome the shortcomings of traditional toxicology and lay the foundation for drug safety evaluation, but also save a lot of mannal labour, material resources, and financial resources. In this paper, we are going to review on the methods of drug toxicity predetermination and potential toxicity evaluation and also give an overlook of their application on the safety evaluation of CMM.

  15. 小儿反复呼吸道感染中药新药临床试验设计与评价技术指南%Guideline on evaluation of new drug of Chinese materia medica for treatment of recurrent respiratory tract infections in children

    Institute of Scientific and Technical Information of China (English)

    中华中医药学会儿科分会临床评价学组

    2015-01-01

    《儿科常见疾病中药新药临床试验设计与评价技术指南》是中华中医药学会儿科分会临床评价学组制定的、指导儿科中药Ⅱ、Ⅲ期临床试验和上市后有效性再评价方案设计的、具有病种特色的系列临床评价技术指南,旨在推动儿科中药临床试验设计与评价水平的提高,并为临床提供安全有效的儿童用药.采用世界卫生组织(WHO)推荐的“共识会议法”和美国国立卫生研究院(NIH)发展共识方案(GPP)有关原则,国内全部18个国家药物临床试验机构中医儿科专业的临床儿科专家以及国内相关临床评价专家参加了急性上呼吸道感染、急性支气管炎、支气管哮喘、反复呼吸道感染、厌食、轮状病毒性肠炎、注意缺陷-多动障碍、抽动障碍、遗尿症、手足口病、湿疹11个儿科常见病种指南的起草或多次提出修改建议,历经3年反复完善,最终形成共识,并由中华中医药学会儿科分会于2013年10月发布.本指南从研究背景、研究目标、总体设计、诊断标准、受试者的选择、给药方案、安全性评价、有效性评价、试验流程、数据管理与统计分析、质量保证、相关伦理学要求、试验结束后的医疗措施、资料保存等方面阐述了小儿反复呼吸道感染中药新药临床试验的设计与评价技术要点,期望能为申办者与研究者在临床试验方案设计中提供指导.

  16. 治疗心力衰竭中药新药奇丹片的项目定量价值评估%Quantitative value evaluation of new drug Qidan Tablet project in Chinese materia medica with function of curing heart failure

    Institute of Scientific and Technical Information of China (English)

    闫凯; 李认书; 周水平; 李云飞; 孙鹤

    2012-01-01

    科学量化的新药项目价值评估方法是新药研发管理者决策的重要依据,影响着新药项目的命运.目前,我国对新药研发项目价值的定量评估研究尚不成熟,实物期权法的应用发展为此提供了新的方法.二叉树模型是实物期权法用于新药项目价值定量评估的模型之一,以治疗心力衰竭中药新药奇丹片为例,探讨如何运用二叉树模型对新药项目进行定量价值评估,包括模型中不确定性参数的确定、模型的构建以及评价步骤,旨在将二叉树模型引入新药项目的定量价值评估,推动我国新药研发项目管理中定量评价工具的运用,期望达成业界共识,为新药项目的管理、市场交易与谈判提供科学可行、易接受的方法与工具.

  17. Published papers about Salvia miltiorrhiza Bunge as a Chinese medicinal material

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Xu Cuihong, Shu Zhiming, Wang Yan, Miao Fang, Zhou ke. The accumulation rule of the main medicinal components in different organs of Salvia miltiorrhiza Bunge. and Salvia miltiorrhiza Bunge. f. alba. Lishizhen Medicine and Materia Medica Research, 2010, 21(09): 2129-2132. Email: miaofangmf@ 163,com

  18. Chinese medicinal herbs as source of antioxidant compounds--where tradition meets the future.

    Science.gov (United States)

    Matkowski, A; Jamiołkowska-Kozlowska, W; Nawrot, I

    2013-01-01

    Medicinal plants are an essential part of Traditional Chinese Medicine (TCM), an ancient complex therapy considered today as one of the most complete complementary medicine system. Chinese Herbal Medicines (CHM) listings included in Chinese Materia Medica cover more than 1500 plants and a great number of composite preparations. Recently, several TCM herbs have been included into European Pharmacopoeia and many more are on the waiting list. The efficiency of TCM is based on the reinforcing of an organism's natural healing power and the ability to restore the energy homoeostasis. A likely mechanism of at least some of the activities is interacting with redox balance and prevention of oxidative stress. During the past two decades, hundreds of crude herbs, extracts, and isolated compounds have been screened for their antioxidant properties in vitro and in vivo. Consequently, some of traditional Chinese herbs can be regarded as source of very efficient antioxidant compounds, and this activity could explain some of their therapeutic and preventive usefulness. In this review, we outline the recent achievements in the worldwide quest for more efficient antioxidants, with Chinese medicinal and food plants in the central point. Various classes of antioxidant compounds will be mentioned, such as polyphenols or terpenoids that can act either as direct reactive oxygen species scavengers, transition metal reducers and chelators, or as chain breaking antioxidants. Some methodological considerations will be also discussed, with emphasis on the potential importance of the results obtained with antioxidant assays for human health and disease prevention. In this context, several examples of selected, most promising Chinese medicinal plants will be also presented in more detail.

  19. Tendencias francesas en materia de dolo

    Directory of Open Access Journals (Sweden)

    Aude Denizot-Libreros

    2014-07-01

    Full Text Available Numerosos fallos recientes de la Corte de Casación francesa en materia de dolo han suscitado nuevas investigaciones en la materia. El dolo siempre ha sido una noción ambigua, objeto de un sinnúmero de discusiones. El propósito que se persigue consiste en ofrecer un panorama muy general de las tendencias francesas en esta materia. Estudiar estas tendencias, doctrinales y jurisprudenciales, implica confrontarse con varios temas espinosos, especialmente los de la reticencia, el dolo incidente y el dolo por parte del tercero. También se analiza el dolo con relación a otros conceptos: el error sobre el valor, el error inexcusable, y, en materia de sanción, tanto la pérdida de oportunidad como la noción de refacción del contrato. Entre debates doctrinales y vacilaciones jurisprudenciales, en este tema el derecho francés se caracteriza más por sus aproximaciones que por su rigor, delineando por contraste los impases a evitar.

  20. Creato un nuovo stato della materia

    CERN Multimedia

    Valsecchi, M C

    2004-01-01

    "Nei laboratori di tutto il mondo nascono continuamente nuovi materiali plastici, leghe di metallo, molecole progettate e assemblate atomo per atomo. I ricercatori dell'Istituto nazionale di fisica nucleare hanno fatto un passo in piu': manipolando i costituenti fondamentali dei nuclei atomici, hanno creato una nuova forma di materia, radicalmente diversa da quella che noi conosciamo" (1 page)

  1. Tendencias francesas en materia de dolo

    Directory of Open Access Journals (Sweden)

    Aude Denizot-Libreros

    2014-06-01

    Full Text Available Numerosos fallos recientes de la Corte de Casación francesa en materia de dolo han suscitado nuevas investigaciones en la materia. El dolo siempre ha sido una noción ambigua, objeto de un sinnúmero de discusiones. El propósito que se persigue consiste en ofrecer un panorama muy general de las tendencias francesas en esta materia. Estudiar estas tendencias, doctrinales y jurisprudenciales, implica confrontarse con varios temas espinosos, especialmente los de la reticencia, el dolo incidente y el dolo por parte del tercero. También se analiza el dolo con relación a otros conceptos: el error sobre el valor, el error inexcusable, y, en materia de sanción, tanto la pérdida de oportunidad como la noción de refacción del contrato. Entre debates doctrinales y vacilaciones jurisprudenciales, en este tema el derecho francés se caracteriza más por sus aproximaciones que por su rigor, delineando por contraste los impases a evitar.

  2. La rilevanza del concetto medico-legale di «complicanze» nei giudizi di responsabilità medica

    Directory of Open Access Journals (Sweden)

    Mirko Faccioli

    2015-12-01

    Full Text Available Con la pronuncia n. 13328 del 30 giugno 2015, la Corte di Cassazione si è occupata della rilevanza che nei giudizi di responsabilità civile medica deve attribuirsi al concetto di «complicanza», espressione con la quale – secondo la Suprema Corte – «la medicina clinica e la medicina legale designano solitamente un evento dannoso, insorto nel corso dell’iter terapeutico, che pur essendo astrattamente prevedibile, non sarebbe evitabile» e che, come tale, esclude la sussistenza della responsabilità in discorso. Affermando principi che, come meglio vedremo, sembrano porsi in distonia con il consolidato orientamento giurisprudenziale in materia, la pronuncia in esame ha sostenuto che «tale concetto è inutile nel campo giuridico.

  3. The journey,gain,and thought from engaging in the research of Chinese herbal medicines in China,Japan,and United States%The journey, gain, and thought from engaging in the research of Chinese herbal medicines in China, Japan, and United States

    Institute of Scientific and Technical Information of China (English)

    LIUYan-ze; DENG Zhu-ping

    2011-01-01

    Since early 80s of last century,Chinese herbal medicines focused on the isolation and structural identification of active/chemical compounds have being investigated,started the journey from Henan College of Traditional Chinese Medicine.After one year (1985~ 1986) advanced study in Prof.Jingxi Xie's laboratory in the Institute of Materia Medica,Chinese Academy of Medical Sciences in Beijing,further studies in Prof.Takuo Okuda's laboratory,Okayama University,Japan as a guest researcher from 1988 to 1992 opened a fresh and amazing gate of tannin chemistry.Near 10 years'investigation of tannins and related polyphenols from Chinese herbal medicines,supported by National Natural Science Foundation of China and other grants,some typical herbs containing tannins and related polyphenols as major active components have been in-depth studied,such as Loropetalum chinense,Epilobium angustifolium,Rhodmyrtus tomentosa,Lythrum salicaria,Epilobium pyrricholophum,Rodgersia podoph ylla,Punica granatum,Euphorbia humifusa,and Cornus of ficinalis etc.Hundreds of diversified tannins and related polyphenols have been isolated including monomer,dimmer,trimer of ellagitannins and C-glycosidic tannins etc.

  4. Medicaments as the possible cause of urticaria in children.

    Science.gov (United States)

    Balaban, Jagoda

    2002-09-01

    Medicaments are reported as the most common cause of urticaria. The objective of this study was to determine, by retrospective analysis of 132 pediatric patients treated at the Pulmonology and Allergology ward of the Department of Pediatrics, Banja Luka, over a 5-year period, the scope to which medicaments act as the possible cause of urticaria. Results of the study showed that the disease manifested mostly in male children (59.8), mainly of pre-school and school age rather than <1 year age group. Acute urticaria predominated, and it was recorded in 91.7% of cases. A medicament as the possible etiologic factor of acute urticaria was found in 29.8% of cases. Regarding chronic urticaria, in most cases the cause of disease remained unknown (63.6%), whereas a medicament and infection as the possible causal factors were found in 9.1% of cases. Before the occurrence of urticaria, 37 (28%) children took some medicament. Usually, these were antibiotics (45.9%), antipyretics (35.1%), or a combination of antibiotics and antipyretics (16.2%). Penicillin V, G or ampicillin were the most frequently used antibiotics (88.2%), whereas acetylsalicylic acid was the most frequently used antipyretic (53.8%). In 28% of the children suffering from acute urticaria, apart from taking some medicament, clinically manifested infection was also recorded, mostly of the respiratory system, so it could not be stated for sure whether the medicament or infection was the etiologic factor for the occurrence of disease. In only two cases it could be stated for sure that a medicament was the cause of urticaria, one acute and chronic urticaria each

  5. Combustión turbulenta de materia nuclear en materia extraña

    Science.gov (United States)

    Vucetich, H.

    La simulación numérica de supernovas tipo II muestra que los mecanismos físicos convencionales no son suficientes como para producir la explosión. La detonación de materia nuclear en materia extraña es un mecanismo físico capaz de proveer la energía faltante en las simulaciones. En esta comunicación se muestra que la turbulencia en el corazón compacto de una supernova, después del primer choque, es capaz de transformar una combustión lenta en una detonación. Se concluye que, si la materia extraña existe, todas las ``estrellas de neutrones'' son, en realidad, ``estrellas extrañas''.

  6. Tien 'stuks wintergezigten in Tartarijen op doek geschilderd' - Chinese exportwinterlandschappen in Museum Volkenkunde

    NARCIS (Netherlands)

    Poel, van der R.H.M.

    2011-01-01

    Onderzoek naar de herkomst van tien zeldzame Chinese exportwinterlandschappen in Rijksmuseum Volkenkunde in Leiden. Daarnaast worden de tien eind-18e, begin-19e-eeuwse hybride Chinese olieverfschilderingen nader beschouwd vanuit iconografisch oogpunt, compositie, technische toepassingen en materiaal

  7. Statistical modeling methods to analyze the impacts of multiunit process variability on critical quality attributes of Chinese herbal medicine tablets

    Directory of Open Access Journals (Sweden)

    Sun F

    2016-11-01

    Full Text Available Fei Sun,1 Bing Xu,1,2 Yi Zhang,1 Shengyun Dai,1 Chan Yang,1 Xianglong Cui,1 Xinyuan Shi,1,2 Yanjiang Qiao1,2 1Research Center of Traditional Chinese Medicine Information Engineering, School of Chinese Materia Medica, Beijing University of Chinese Medicine, 2Key Laboratory of Manufacture Process Control and Quality Evaluation of Chinese Medicine, Beijing, People’s Republic of China Abstract: The quality of Chinese herbal medicine tablets suffers from batch-to-batch variability due to a lack of manufacturing process understanding. In this paper, the Panax notoginseng saponins (PNS immediate release tablet was taken as the research subject. By defining the dissolution of five active pharmaceutical ingredients and the tablet tensile strength as critical quality attributes (CQAs, influences of both the manipulated process parameters introduced by an orthogonal experiment design and the intermediate granules’ properties on the CQAs were fully investigated by different chemometric methods, such as the partial least squares, the orthogonal projection to latent structures, and the multiblock partial least squares (MBPLS. By analyzing the loadings plots and variable importance in the projection indexes, the granule particle sizes and the minimal punch tip separation distance in tableting were identified as critical process parameters. Additionally, the MBPLS model suggested that the lubrication time in the final blending was also important in predicting tablet quality attributes. From the calculated block importance in the projection indexes, the tableting unit was confirmed to be the critical process unit of the manufacturing line. The results demonstrated that the combinatorial use of different multivariate modeling methods could help in understanding the complex process relationships as a whole. The output of this study can then be used to define a control strategy to improve the quality of the PNS immediate release tablet. Keywords: Panax

  8. Pulpotomy Medicaments used in Deciduous Dentition: An Update.

    Science.gov (United States)

    Al-Dlaigan, Yousef H

    2015-06-01

    The aim of this paper was to review the history and the scientific literature published on pulpotomy medicaments and to present the findings of these studies. The review showed that pulpotomy of primary teeth has been treated with many different techniques and medicaments, that some of these approaches are controversial and that their results have presented variables of success rates in term of clinical, radiographic and histologic observation. It is important that all clinicians, particularly for pediatric dentists, be up to date with the recent trends in this area of dental treatment for children.

  9. 民国中西药学汇通代表作《汉药新觉》考略%Textual research on the Han yao xin jue (New Recognition of Chinese Medicines), a representative book of amalgamation of Chinese and western pharmacy in the Republican period

    Institute of Scientific and Technical Information of China (English)

    陈仁寿

    2013-01-01

    郭若定《汉药新觉》为民国时期中西药学汇通的代表作,其上集曾被民国时期北平杂志《明日医药》连载,并刊有单行本.续集内容由其家属收藏,全书完整本于2010年由上海科学技术文献出版社出版,载药208种,以单味中药为主,并收部分复方药及西药.该书中西药学汇通思想,体现在3个方面:中西药物,兼收并蓄;衷中参西,继承创新;中西合参,旨在汇通.%Guo Ruo-ding's Han yao xin jue (New Recognition of Chinese Medicines) was the representative work of amalgamating Chinese and western pharmacy of the Republican period.Its first volume was published in Medicine Tomorrow in Peiping in installments,also with offprints; while the second volume was collected by his relatives.The whole book was published by the Shanghai Press of Science and Technology,carrying 208 kinds of Chinese materia medica mainly with individual drug descriptions,some compound prescriptions,and some western medicines.The amalgamating idea was expressed in three points:collection of both Chinese and western drugs; inheritance and creation with new idea of amalgamating Chinese and western medical systems; mutual consultation of Chinese and western medicine aiming at their amalgamation.

  10. Technology evaluation: TroVax, Oxford BioMedica.

    Science.gov (United States)

    Reinis, Milan

    2004-08-01

    TroVax, a gene-based tumor vaccine that uses a poxvirus vector to deliver the tumor antigen gene 5T4, is under development by Oxford BioMedica for the potential treatment of cancer. TroVax is undergoing phase II clinical trials.

  11. La realidad como materia novelable: Alejo Carpentier

    OpenAIRE

    Raquel Arias Careaga

    2007-01-01

    Desde que en 1897 Benito Pérez Galdós defendiera como materia prima legítima de la literatura «la vida misma, de donde el artista saca las ficciones que nos instruyen y embelesan» (Pérez Galdós, 1990: 159), el realismo como instrumento de indagación y análisis de la sociedad no ha dejado de crecer y expandirse. Realismo crítico, como este de Galdós, que implica una ampliación del concepto chato de «realidad», incluyendo en ella «recuerdos, sueños, imaginación, locura, símbolos» para contribui...

  12. Radiaciones ionizantes y efectos sobre la materia

    Directory of Open Access Journals (Sweden)

    Sandra Magaly Medina Araujo

    2002-01-01

    Full Text Available Las radiaciones ionizantes, además, de tener muchas aplicaciones benéficas tanto en el campo industrial como en los organismos vivientes, presentan también muchos efectos nocivos que se deben evitar, sobre todo cuando se trata de fuentes artificiales con las que pueden presentarse abusos en su utilización, especialmente en la parte clínica. Este artículo, el primero de una serie de divulgaciones acerca del tema, pretende dar a conocer las características y efectos sobre la materia, de las mencionadas radiaciones, así como algunas recomendaciones acerca del manejo y tralAS, tamiento de dichas radiaciones

  13. Effects of traditional Chinese medicine Fu Zheng decoction on the immunological function and clinical prognosis of the elderly patients with pneumonia.

    Science.gov (United States)

    Li, Hongqiang; Xu, Shumin; Cheng, Tingting; Tang, Lunxian; Bai, Jianwen; Lin, Minjia

    2015-01-01

    Pneumonia is one of the most serious infectious diseases for elderly people who have impaired organ functions and are more susceptible to infection. Elderly patients having pneumonia often need long-term hospitalization, leading to declined quality of life, and increase of financial burden to the society and their family. Therefore, studies on novel therapeutic strategies and the clinical prognosis of the pneumonia patients are imperative. In the present study, we found that the Chinese herbal medicine Fu Zheng decoction had great immunomodulatory effects during the recovery period of elderly pneumonia patients. Patients treated with combined treatment of Fu Zheng decoction and antibiotic had a faster decline of temperature and a more significant decrease of C reactive protein and inflammatory factors level, and it is easier for them to cough off phlegm, compared with the antibiotic only treatment. Furthermore, the inflammation absorption and the reduction of NK-cell proportion as well as the inflammatory factors were more remarkable in the patients taken Fu Zheng decoction. Especially, the Fu Zheng decoction treatment could decrease the duration of antibiotic treatment, which may help reduce the side effects of antibiotics. Our study also found that MyD88 might play a role in the immunomodulatory effect of Fu Zheng decoction. Our study provides novel insight for the further development of intravenous injection of Chinese materia medica preparation on the regulation of immune function.

  14. Chinese traditional medicine for induction of ovulation

    Institute of Scientific and Technical Information of China (English)

    肖碧莲

    2003-01-01

    This is a review paper of some effective recipes of Chinese traditional medicine usedin ovulation induction and treatment of gynecological diseases. Some clinical results bygynecologists using Chinese traditional medicine in combination with western medicineand results from research on traditional medicine with modern technology are presented.A list of frequently used traditional medicine for ovulation induction are selected from the famous Compendium of Materica Medica(本草纲目)by Li Shi-zhen(李时珍).

  15. Discoloration of Roots Caused by Residual Endodontic Intracanal Medicaments

    Directory of Open Access Journals (Sweden)

    Belinda Kuan-Jung Chen

    2014-01-01

    Full Text Available Aims. This study examined the extent to which intervisit corticosteroid-based antibiotic pastes (CAP medicaments contribute to staining of tooth structure after attempted removal by irrigation techniques. Methods. A total of 140 roots were prepared and the canals were filled with Ledermix paste (demeclocycline, Odontopaste (clindamycin, and Doxypaste (doxycycline. The pastes were removed after 2 or 4 weeks of storage in the dark using EDTA and NaOCl with either a 27-gauge-slotted needle or an EndoActivator (Dentsply. The roots were then exposed to an intense light source for 30 minutes each week and photographed after a further 1, 3, or 6 months. Digital images were standardized and data for changes in luminosity were analysed using repeated measures ANOVA and a post hoc test. Results. Removal of the medicament did not prevent later discolouration. There was no significant difference between the paste removal methods. Ledermix paste caused the greatest darkening compared to the untreated controls, for both application periods and both methods of removal. Doxypaste and Odontopaste caused less darkening than Ledermix. Conclusion. Medicaments that stain teeth may continue to discolour teeth despite best attempts to remove them. This study stresses the importance of material selection and minimising contact of Ledermix within the coronal aspects of teeth.

  16. Ancient Records and Modern Research on the Mechanisms of Chinese Herbal Medicines in the Treatment of Diabetes Mellitus

    Directory of Open Access Journals (Sweden)

    Hai-ming Zhang

    2015-01-01

    Full Text Available Over the past decades, Chinese herbal medicines (CHM have been extensively and intensively studied through from both clinical and experimental perspectives and CHM have been proved to be effective in the treatment of diabetes mellitus (DM. This study, by searching ancient records and modern research papers, reviewed CHM in terms of their clinical application and principal mechanism in the treatment of DM. We summarized the use of CHM mentioned in 54 famous ancient materia medica monographs and searched papers on the hypoglycemic effect of several representative CHM. Main mechanisms and limitations of CHM and further research direction for DM were discussed. On the basis of the study, we were led to conclude that TCM, as a main form of complementary and alternative medicine (CAM, was well recorded in ancient literatures and has less adverse effects as shown by modern studies. The mechanisms of CHM treatment of DM are complex, multilink, and multitarget, so we should find main hypoglycemic mechanism through doing research on CHM monomer active constituents. Many CHM monomer constituents possess noteworthy hypoglycemic effects. Therefore, developing a novel natural product for DM and its complications is of much significance. It is strongly significant to pay close attention to CHM for treatment of DM and its complications.

  17. A novel strategy for the discrimination of gelatinous Chinese medicines based on enzymatic digestion followed by nano-flow liquid chromatography in tandem with orbitrap mass spectrum detection

    Directory of Open Access Journals (Sweden)

    Yang H

    2015-08-01

    Full Text Available Huan Yang,1,2 Yuping Shen,1 Ying Xu,1 Aida Serra Maqueda,2 Jie Zheng,1 Qinan Wu,3 James P Tam21Department of Chinese Materia Medica and Pharmacy, School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu, People’s Republic of China; 2Division of Structural Biology and Biochemistry, School of Biological Sciences, College of Science, Nanyang Technological University, Singapore; 3Department of Chinese Medicine Authentication, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People’s Republic of ChinaAbstract: Gelatinous Chinese medicines made from mammalian skin or horn or reptile shell are a very important type of animal-derived Chinese medicine. They have been extensively used either as both hemopoietic and hemostatic agents to treat vertigo, palpitation, hematuria, and insomnia in traditional Chinese medicine clinics; consumed as a popular tonic for weaker persons such as the elderly or women after giving birth; or further manufactured to health supplements for certain populations. However, they cannot be discriminated from each other by only using the routine approach in the Chinese Pharmacopoeia, as it lacks enough specificity and, consequently, and the requirements can be met even by adding assayed ingredients. In this study, our efforts to differentiate three gelatinous Chinese medicines, Asini Corii Colla, Cervi Cornus Colla, and Testudinis Carapacis ET Plastri Colla, are presented, and a novel strategy based on enzymatic digestion followed by nano-flow liquid chromatography in tandem with orbitrap mass spectrum detector analysis is proposed herein. Fourteen diagnostic fragments identified from the digests of these medicines were exclusively selected for their discrimination. By taking advantage of the favorable features of this strategy, it is feasible and convenient to identify enzymatic-digested peptides originated from signature proteins in each medicine, which thus could be employed as potential

  18. El efecto de los neutrinos degenerados en la transición de materia nuclear a materia de quarks

    Science.gov (United States)

    Lugones, G.; Benvenuto, O. G.

    Se estudia la transicion de materia nuclear a materia de quarks en presencia de un gas degenerado de neutrinos electrónicos y muónicos. Se muestra que la presencia de los neutrinos hace que las densidades de desconfinamiento de quarks sean notablemente mayores que las encontradas en el caso en que no haya neutrinos presentes. Se discuten las posibles consecuencias de este efecto en explosiones de supernova y evolución de proto estrellas de neutrones.

  19. La realidad como materia novelable: Alejo Carpentier

    Directory of Open Access Journals (Sweden)

    Raquel Arias Careaga

    2007-12-01

    Full Text Available Desde que en 1897 Benito Pérez Galdós defendiera como materia prima legítima de la literatura «la vida misma, de donde el artista saca las ficciones que nos instruyen y embelesan» (Pérez Galdós, 1990: 159, el realismo como instrumento de indagación y análisis de la sociedad no ha dejado de crecer y expandirse. Realismo crítico, como este de Galdós, que implica una ampliación del concepto chato de «realidad», incluyendo en ella «recuerdos, sueños, imaginación, locura, símbolos» para contribuir a la formación de un «realismo total» (Rodríguez Puértolas, 2000, II: 93, al que se une también la asimilación de enseñanzas esenciales como la que representa la narrativa de Cervantes: La novelística de Galdós hunde sus raíces en el mejor Cervantes, como puede verse en su peculiar sentido del humor y de la ironía, en la concepción perspectivista de la realidad y en tantas otras cosas, algunas de ellas en verdad fundamentales. Así el concepto de la Naturaleza y sus relaciones dialécticas con el ser humano; así el Amor como elemento vital y animador del orden cósmico, muy alejado del idealismo vulgar romántico (Ibid., 93.

  20. Materia y Pobreza = Matter and Poverty

    Directory of Open Access Journals (Sweden)

    María Teresa Muñoz

    2013-10-01

    Full Text Available ResumenLa acumulación material es uno de los signos más identificables de la pobreza. El pobre vive apegado a la tierra, esa es su única posesión y a partir de ella construirá sus refugios, sus habitaciones, sus utensilios. Las construcciones de arcilla, de barro, moldeadas con gran abundancia de materia  se encuentran en los poblados primitivos, pero cualquier situación marcada por la extrema pobreza lo estará también por las acumulaciones de material. Resulta inimaginable una situación de pobreza que no implique la acumulación de materia y esto es particularmente evidente en las sociedades desarrolladas, donde un mendigo es reconocible por su montaña de ropas, calzado o enseres de todo tipo.Resulta, sin embargo, significativo que en los discursos de los ideólogos de la modernidad, la identificación de ésta con el advenimiento de una sociedad sin clases venga acompañada de una apelación a la pobreza, una nueva pobreza fría y sobria, propia de una habitación humana abierta y transparente, casi desnuda, e igualitaria para todos los hombres sin distinción de clases sociales. Así, la pobreza moderna estaría ligada al material, a los nuevos materiales, pero no es una condición impuesta, sino elegida, o al menos aceptada como inevitable por el nuevo hombre.La convivencia entre una pobreza de la acumulación material y una pobreza de ascetismo y renuncia es un hecho tanto en los discursos como en las obras de las vanguardias del siglo XX. La acumulación de materia informe y trabajada manualmente tiene lugar al mismo tiempo que la exhibición de la desnudez y la frialdad de los materiales producidos por la industria.  Y en ambos casos, se apela a la pobreza como última referencia para las obras que tratan de ser una expresión fiel de las aspiraciones de su época.Palabras clavemateria, pobreza, material, acumulación, modernidad, sociedadAbstractAccumulation of matter is one of the most recognizable signs of poverty. The poor

  1. Papers are welcome

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    Acta Pharmacologica Sinica (APS), the offical journal of the Chinese Pharmacological Society, is undertaken byShanghai Institute of Materia Medic.a, Chinese Academy of Sciences. The APS is listed in Biological Abstracts,Chemical Abstracts, Current Contents/Life Sciences, Excerpta Medica, Index Medicus, MEDLINE, Research Alert,Science Citation Index, SciSearch, Tropical Diseases Bulletin, and many other abstracting indexes.

  2. 76 FR 12308 - Listing Endangered and Threatened Species: 90-Day Finding on a Petition to List Six Species of...

    Science.gov (United States)

    2011-03-07

    ... listed as materia medica in traditional Chinese medicine: liver, ova, and bile (Han and Xu, 1992) as well... occurred (McDavitt, 2002). Indonesia enacted legislation to protect sawfishes (and five other...

  3. 中药“十八反”基层医院应用现状调查%Research on Application Status of Eighteen Incompatible Medicaments in Primary Hospital

    Institute of Scientific and Technical Information of China (English)

    于大猛; 瞿融; 范欣生; 杨杰

    2012-01-01

    To investigate application status of eighteen incompatible medicaments in primary hospital. We searched 78 ,238 recipes originated from a county hospital of traditional Chinese medicine and 9 health clinics in towns and townships between 2008 and 2011. All recipes containing eighteen incompatible medicaments were statistically analyzed. Two handred and fifty-five recipes containing eighteen incompatible medicaments were found. There were 198 recipes in aconite group and 57 recipes in radix glycyrrhizae group. No recipe in veratrinigri group was found. Radix Aooniti Lateralis preparata in combination with Rhizoma Pinelliae was the most common formula of all eighteen incompatible medicaments. Most clinicians hold a negative attitude to application of eighteen incompatible medicaments. Application of eighteen incompatible medicaments in primary hospital is objectively existent, and it is not absolutely contraindicated.%调查基层医院应用中药十八反的现状.检索某县级中医院及9所乡镇卫生院2008-2011年的处方78 238首,对其中含十八反药对的处方进行统计分析.结果表明共发现含十八反药对的处方255首,其中乌头组198首,甘草组57首,藜芦组0首,以附子半夏应用最多,并出现多组反药同用的情况,临床医生对十八反问题多持回避态度.中药十八反在基层医院的应用是客观存在的,并非绝对的禁总.

  4. LXY6090 – a novel manassantin A derivative – limits breast cancer growth through hypoxia-inducible factor-1 inhibition

    OpenAIRE

    Lai, Fangfang; Liu, Qian; LIU, Xiaoyu; Ji, Ming; Xie, Ping; Chen, Xiaoguang

    2016-01-01

    Fangfang Lai,1 Qian Liu,2 Xiaoyu Liu,3 Ming Ji,1 Ping Xie,3 Xiaoguang Chen1 1Department of Pharmacology, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 2Department of Pharmacology, National Institutes for Food and Drug Control, 3Department of Pharmacochemistry, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Be...

  5. LXY6090 – a novel manassantin A derivative – limits breast cancer growth through hypoxia-inducible factor-1 inhibition

    OpenAIRE

    Lai F; Liu Q; Liu X; Ji M; Xie P; Chen X

    2016-01-01

    Fangfang Lai,1 Qian Liu,2 Xiaoyu Liu,3 Ming Ji,1 Ping Xie,3 Xiaoguang Chen1 1Department of Pharmacology, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 2Department of Pharmacology, National Institutes for Food and Drug Control, 3Department of Pharmacochemistry, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Be...

  6. Juliano Moreira e a Gazeta Medica da Bahia

    OpenAIRE

    Jacobina, Ronaldo Ribeiro; Gelman,Ester Aida

    2008-01-01

    Estudos recentes sobre Juliano Moreira enfatizam sua obra no Rio de Janeiro (1903-1933), mas o objetivo central deste artigo é descrever sua contribuição na Gazeta Medica da Bahia, em período anterior (1893-1903). Descreve a trajetória dessa revista que serviu de veículo para as pesquisas originais da Escola Tropicalista Bahiana. Apresenta a produção de Moreira na Gazeta, em que ele surge como estudioso nas áreas de dermatologia, sifilografia e parasitologia, tendo identificado, pela primeira...

  7. Enhanced stability and antibacterial efficacy of a traditional Chinese medicine-mediated silver nanoparticle delivery system

    Directory of Open Access Journals (Sweden)

    Sun WJ

    2014-11-01

    Full Text Available Wenjie Sun,1,2,* Ding Qu,1,* Yihua Ma,1 Yan Chen,1,2 Congyan Liu,1 Jing Zhou11Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, 2Department of Pharmaceutics, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People’s Republic of China*These authors contributed equally to this workAbstract: Silver nanoparticles (AgNPs are widely used as antibacterial products in various fields. Recent studies have suggested that AgNPs need an appropriate stabilizer to improve their stability. Some antibacterial traditional Chinese medicines (TCMs contain various reductive components, which can not only stabilize AgNPs but also enhance their antimicrobial activity. In this study, we developed a series of novel AgNPs using a TCM extract as a stabilizer, reducing agent, and antimicrobial agent (TCM-AgNPs. A storage stability investigation of the TCM-AgNPs suggested a significant improvement when compared with bare AgNPs. Further, conjugation of TCMs onto the AgNP surface resulted in stronger antimicrobial potency on antibacterial evaluation using Pseudomonas aeruginosa, Staphylococcus epidermidis, and Staphylococcus aureus with minimum inhibitory concentration 50% (MIC50 ratios (and minimum bactericidal concentration 90% [MBC90] ratios of AgNPs to respective TCM-AgNPs as assessment indices. Among these, P. cuspidatum Sieb. et-conjugated AgNPs (P.C.-AgNPs had the advantage of a combination of TCMs and AgNPs and was studied in detail with regard to its synthesis and characterization. The extraction time, reaction temperature, and concentrations of AgNO3 and Polygonum cuspidatum Sieb. et extract were critical factors in the preparation of P.C.-AgNPs. Further, the results of X-ray diffraction and Fourier transform infrared spectroscopy indicated successful preparation of P.C.-AgNPs. In representative studies, P.C.-AgNPs showed a well-defined spherical shape, a homogeneous

  8. Anàlisi de la utilització de medicaments en població pediàtrica i adulta. utilització de medicaments en condicions no aprovades

    OpenAIRE

    Danés Carreras, Immaculada

    2015-01-01

    Els estudis d'utilització de medicaments permeten identificar els patrons d'ús dels medicaments en diferents poblacions, ja siguin adults o nens. Un aspecte és l’anàlisi de l’ús de medicaments en condicions diferents a les autoritzades a la fitxa tècnica. Aquesta tesi és una anàlisi de diferents aspectes de l’ús de medicaments en condicions no aprovades després que es publiqués el Reial Decret 1015/2009 del 19 de juny pel qual es regula la disponibilitat de medicaments en diferents situacions...

  9. Anàlisi de la utilització de medicaments en població pediàtrica i adulta utilització de medicaments en condicions no aprovades /

    OpenAIRE

    Danés Carreras, Immaculada; Vallano Ferraz, Antonio

    2015-01-01

    Els estudis d'utilització de medicaments permeten identificar els patrons d'ús dels medicaments en diferents poblacions, ja siguin adults o nens. Un aspecte és l'anàlisi de l'ús de medicaments en condicions diferents a les autoritzades a la fitxa tècnica. Aquesta tesi és una anàlisi de diferents aspectes de l'ús de medicaments en condicions no aprovades després que es publiqués el Reial Decret 1015/2009 del 19 de juny pel qual es regula la disponibilitat de medicaments en diferents situacions...

  10. Trazando la materia oscura con cúmulos globulares

    Science.gov (United States)

    Forte, J. C.

    Se describe la estrategia adoptada para mapear la distribución de materia oscura y bariónica en galaxias elípticas cuyos cúmulos globulares están siendo observados con los telescopios VLT y Gemini. Se ejemplifican los resultados con los datos obtenidos en el cúmulo de Fornax.

  11. Gas circundante a un halo de materia obscura

    Directory of Open Access Journals (Sweden)

    Guillermo Arreaga García

    2016-12-01

    Full Text Available Haciendo uso de la técnica SPH (Smooth Particle Hydrodynamic hidrodinámica con partículas suavizadas, realizamos la evolución dinámica de una región representativa del Universo observable. Comparamos los resultados de un modelo cosmológico representado por dos simulaciones, a saber: la de base, en la cual la proporción del número de partículas de materia obscura y de gas es de uno a uno; y la simulación modificada, en la cual aumentamos el número de partículas de gas con la técnica conocida como Particle splitting, mientras dejamos el número de partículas de materia obscura sin cambio como una primera aproximación. El propósito de tales simulaciones es comparar las propiedades de aglomeración del gas, tanto del original como del adicional, en torno a un halo de materia obscura escogido. En este trabajo, nos conformamos con hacer una comparación cualitativa mediante gráficas, en las cuales mostramos como resultado principal que el gas adicional sigue un patrón filamental de formación de cúmulos densos dirigidos hacia el halo de materia obscura escogido.

  12. A ten-year audit of traditional Chinese medicine and other natural product research published in the Chinese Medical Journal (2000-2009)

    Institute of Scientific and Technical Information of China (English)

    Richard A. Collins

    2011-01-01

    Background Clinical research encompasses a wide variety of disciplines. Traditional Chinese medicine (TCM) and natural product research have made great contributions to preventing and treating illness. The number and content of original research reports evaluating TCM and natural products have not previously been described. Information in this area will identify areas of relative strength and weakness in terms of knowledge gaps with respect to clinical conditions and natural product remedies.Methods Original research reports (i.e. original articles, brief reports, and research letters) published in the Chinese Medical Journal (CMJ) from January 2000 to December 2009 evaluating TCM and other natural products were reviewed.The United Kingdom Clinical Research Collaboration (UK-CRC) Health Research Classification System was used to analyze the type of health research conducted. Further analysis on the major illnesses addressed and the major herbal components utilized was conducted.Results One hundred and seventeen original research reports involving TCM or other natural products were identified,comprising 3.82% of the CMJ output in the period covered by this study. Of the different materia medica described in these reports, 74.4% were derived exclusively from plant material, 10.3% from animals, 3.4% from fungi, 1.7% from minerals, and 10.3% were of mixed (plant / animal / fungal / mineral) composition. Twelve herbs were investigated exclusively or were constituents of 66/87 (75.9%) of the plant-based materia medica investigated. Panax ginseng was the most commonly investigated herb or constituent (14/87, 16.1%), followed by Astragalus membranaceus (9/87, 10.3%),Coptis chinensis/Berberis spp. (7/87, 8.0%) and Rheum spp. (7/87, 8.0%). Four UK-CRC health categories accounted for the majority of TCM and other natural product research (cancer, 20.9%; cardiovascular, 19.2%; oral/gastrointestinal,9.8%; and inflammatory/immune, 9.0%). The most common research activity was

  13. 分析《中药学专论》教学改革,探讨研究生培养新思路%Analysis on Teaching Reform of Monography of Chinese Material Medica and Discussion on New Thoughts of Postgraduate Cultivation

    Institute of Scientific and Technical Information of China (English)

    王忠雷; 杨丽燕; 曾祥伟; 李朋收; 张小华

    2013-01-01

    随着研究生教育发展和竞争加剧,造就一批能够站在医药科技前沿的高层次创新型人才,已成为我国教育改革的当务之急.研究生课程改革作为教学改革中的关键环节之一,将成为研究生教学管理部门认真思考和亟待解决的重要课题.本文拟以北京中医药大学教学改革为切入点,来说明教学改革的必要性,并从校级课题的设置、名师大讲堂的引入、数据库建设、社会实践的设置、奖学金评定及考试方式改革等六个方面,分析探讨中药学专业研究生培养新思路,以期为今后的研究生教学改革提供些许参考.%Recently, along with the development of postgraduate education and more furious competition , cultivating a number of high level innovative talents who stand in the real medical science edge has become the top priority for the reform of Chinese education . As a key part in teaching reform, postgraduate curriculum reform will definitely become a vital issue for administration departments of post - graduate education to take serious consideration and purse proper solutions . This paper intends to take Monography of Chinese Medicine teaching reform conducted by Beijing University of Chinese Medicine as an example , to illustrate the necessity of teaching reform , analyze and discuss the new thoughts of postgraduate cultivation majoring in Chinese Medicine , from the aspects of the university discipline design, introduction of famous expert lectures , database construction , social practice, scholarship evaluation and examination methods , so as to provide some reference to the future graduate teaching reform .

  14. Nodule carbohydrate catabolism is enhanced in the Medicago truncatula A17-Sinorhizobium medicae WSM419 symbiosis

    Directory of Open Access Journals (Sweden)

    Estibaliz eLarrainzar

    2014-08-01

    Full Text Available The symbiotic association between Medicago truncatula and Sinorhizobium meliloti is a well-established model system in the legume-Rhizobium community. Despite its wide use, the symbiotic efficiency of this model has been recently questioned and an alternative microsymbiont, S. medicae, has been proposed. However, little is known about the physiological mechanisms behind the higher symbiotic efficiency of S. medicae WSM419. In the present study, we inoculated M. truncatula Jemalong A17 with either S. medicae WSM419 or S. meliloti 2011 and compared plant growth, photosynthesis, N2-fixation rates, and plant nodule carbon and nitrogen metabolic activities in the two systems. M. truncatula plants in symbiosis with S. medicae showed increased biomass and photosynthesis rates per plant. Plants grown in symbiosis with S. medicae WSM419 also showed higher N2-fixation rates, which were correlated with a larger nodule biomass, while nodule number was similar in both systems. In terms of plant nodule metabolism, M. truncatula-S. medicae WSM419 nodules showed increased sucrose-catabolic activity, mostly associated with sucrose synthase, accompanied by a reduced starch content, whereas nitrogen-assimilation activities were comparable to those measured in nodules infected with S. meliloti 2011. Taken together, these results suggest that S. medicae WSM419 is able to enhance plant carbon catabolism in M. truncatula nodules, which allows for the maintaining of high symbiotic N2-fixation rates, better growth and improved general plant performance.

  15. LaMedica - Eine multimediale online Lehr- und Lernplattform [

    Directory of Open Access Journals (Sweden)

    Stracke, Sylvia

    2006-02-01

    Full Text Available [english] The project LaMedica ( has as its aim the development of a multimedia teaching and learning platform, the compilation of contents for medicine and the implementation of these in the teaching process. An on-line author environment was created which supports a variety of didactic approaches: systematic and networked communication of knowledge, case-based learning, the creation of lectures and learning sequence checks. The teaching contents can be edited and illustrated, and are aimed in particular at students, doctors in continuing education and specialists. An on-line media databank supports the re-use and the exchange of contents on the basis of a content management system through the use of the Learning Objects Metadata standards (LOM. Funding is provided by the Federal Ministry for Education and Research (FKZ NM054A. [german] Das Projekt LaMedica ( hat zum Ziel, eine multimediale Lehr- und Lernplattform zu entwickeln, Inhalte für die Medizin zu erstellen und diese in die Lehre zu implementieren. Es wurde eine on-line Autorenumgebung geschaffen, die sehr unterschiedliche didaktische Ansätze unterstützt: systematische und vernetzte Wissensvermittlung, fallbasiertes Lernen, Erstellung von Vorlesungen und Lernerfolgskontrolle. Die Lehrinhalte können zielgruppenspezifisch aufbereitet und dargestellt werden und richten sich insbesondere an Studenten, Ärzte in der Weiterbildung und Fachärzte. Eine on-line Medien-Datenbank unterstützt die Wiederverwendung und den Austausch von Inhalten auf der Basis eines Content-Management-Systems durch Verwendung des Learning Objects Metadata Standards (LOM. Die Förderung erfolgt durch das BMBF (FKZ NM054A.

  16. 《中国药典》含吡咯里西啶生物碱的中药品种与用药安全%Pyrrolizidine alkaloids-containing Chinese medicines in the Chinese Pharmacopoeia and related safety concerns

    Institute of Scientific and Technical Information of China (English)

    汤俊; 服部征雄

    2011-01-01

    吡咯里西啶类生物碱是一类分布广泛的天然有毒生物碱,存在于许多中草药中,一些品种还被历版所收载.为了掌握(2010版)中含这类生物碱的中药品种的收载情况,本文进行了系统的整理和分析;同时,结合该类生物碱的研究现状及本实验室一些最新研究数据,探讨安全性问题与对策.结果发现新版药典一部现存9种药材品种(不包括饮片)含有肝毒吡咯里西啶类生物碱,并涉及数十种成方制剂;由于大多数品种缺乏该类成分的安全限量检查,其潜在的用药风险可能被忽视.建议开展相关基础研究和进行毒性评价,从而进一步提升相关品种的安全性控制水平,为临床安全用药提供保障.%It has been well-known that many medicinal plants used in traditional Chinese medicine contain hepatotoxic pyrrolizidine alkaloids (HPAs), and some even have been recorded in many editions of the Chinese Pharmacopoeia (ChP). In order to clarify the current status of these PAs-containing Chinese materia medica and proprietary Chinese formulae, the ChP 2010, the newest version, and the related safety issues were thoroughly investigated and analyzed on the current advances in research. Total nine crude drugs (not including the processed slices) were found to contain HPAs, which may be present in tens of Chinese proprietary drugs prepared with these crude drugs. Because of the lack of the alkaloid limitation in most monographs, their potential threats to human health may be underestimated. For this reason, attention should be drawn to the importance of the issue. The key point is to conduct the basic studies immediately on these PA-containing herbal plants or products, whose possible hazards need to be carefully assessed. Further efforts should also be made to elevate the criteria for quality control and ensure the drugs' safety in clinic for human health.

  17. Acta informatica medica is indexed in pubmed and archived in pubmed central.

    Science.gov (United States)

    Masic, Izet

    2013-03-01

    Acta Informatica Medica journal has been accepted for archiving in PubMed Central from 2011 onward. The journal started in 1993 as the official journal of the Society for Medical Informatics of Bosnia and Herzegovina. During the last 3 years, Acta Informatica Medica has een included in almost all prestigious online databases, including PubMed, Scopus and EMBASE. The 20th volume of the journal is fully international, with papers from 18 countries.

  18. Effects of dentin on the antimicrobial properties of endodontic medicaments.

    Science.gov (United States)

    Haapasalo, Markus; Qian, Wei; Portenier, Isabelle; Waltimo, Tuomas

    2007-08-01

    Successful treatment of apical periodontitis is dependent on the elimination of the infective microflora from the necrotic root canal system. Antimicrobial irrigating solutions and other locally used disinfecting agents and medicaments have a key role in the eradication of the microbes. While most if not all presently used disinfecting agents rapidly kill even the resistant microbes when tested in vitro in a test tube, the effectiveness of the same agents is clearly weaker in the in vivo conditions. Recent studies have given valuable information about the interaction of endodontic disinfecting agents with dentin and other compounds present in the necrotic root canal. As a result of such interactions the antimicrobial effectiveness of several of our key disinfectants may be weakened, or even eliminated under certain circumstances. Different disinfectants show different sensitivity to the action by the various potential inactivators, such as dentin, serum proteins, hydroxyapatite, collagen derived from different sources, and microbial biomass. This review is a summary of our present knowledge of the mostly negative interactions between endodontic disinfecting agents and the various compounds present in the root canal environment.

  19. Home Delivery Medicament Program: access, inactivity and cardiovascular risk

    Directory of Open Access Journals (Sweden)

    Roque da Silva Araújo

    Full Text Available ABSTRACT Objective: to verify causes of inactivity in the Home Delivery Medicament Program, as referred by users from a Primary Health Care Service in São Paulo, comparing them to the causes registered in the program and analyzing them in the theoretical model Concept of Access to Health. Methods: cross-sectional study, interviewing 111 inactive users; and documentary study in the program records. Results: half of the users did not know the condition of inactivity. Discrepancies were found between the user's and the program's information, observing different levels of agreement: Absence of physician and administrative staff member 0%; Transfer to other service 25%; Death 50%; Option to quit 50%; Address change 57% and Change in therapeutic schedule 80%. The users' feeling of accepting the program was observed. In the health access concept, inactivity can be explained in the information dimension, in the degree of asymmetry between the patient's and the health professional's knowledge, identified through the indicators: education, knowledge and information sources. Conclusions: due to the low education level, the user does not assimilate the information on the steps of the program flowchart, does not return for the assessment that guarantees its continuity. Consequently, (she stops receiving the medication and spends a long time without treatment, increasing the cardiovascular risk of hypertensive (92% of the sample, diabetic (44% and dyslipidemic patients (31%.

  20. Extraction, Modelling and Purification of Flavonoids from Citrus Medica Peel

    Directory of Open Access Journals (Sweden)

    M. Parvathi Nandan

    2015-12-01

    Full Text Available Soxhlet extraction technique is widely employed for the extraction and separation of chemical constituents in the medicinal plants. Citrus medica L commonly called as Citron belongs to family Rutaceae, is a slow-growing shrub. It is mainly cultivated for the production of edible fruits which are sour in taste like lime and lemon and the main content of a citron fruit is the thick rind, which is very adherent to the segments. From the phytochemical analysis the peel extract is rich source of phenols, flavonoids and alkaloids. The objective of present work is to develop a modelling equation for quercetin, rutin and kaempferol and the crude extract obtained by soxhlet extraction was further purified by solvent-solvent extraction and Column chromatography. Extraction was carried out by 80% methanol as a solvent Soxhlet extractor. Soxhlet extraction with methanol was carried out with varying time intervals, to evaluate modelling equation. The proposed modelling equation was Es = 0.0849(t + 7.0286 for Quercetin and Es = 0.0912(t + 25.971 for rutin, and Es = 0.0267(t + 7.3714 for Kaempferol. High yield was obtained for 180min of Soxhlet extraction with 80% methanol. Yield of quercetin, rutin and kaempferol after solvent-solvent extraction and column chromatography was 22.6µg/ml, 43.7µg/ml and 10.8µg/ml respectively. The proposed model showed good agreement with the experimental data.

  1. The effect of endodontic regeneration medicaments on mechanical properties of radicular dentin

    Science.gov (United States)

    Yassen, Ghaeth H.

    Endodontic regeneration treatment of necrotic immature teeth has gained popularity in recent years. The approach suggests a biological alternative to induce a continuous root development. In this project, three in vitro experiments were conducted to investigate the effect of three medicaments used in endodontic regeneration on mechanical properties and chemical structure of radicular dentin. In the first experiment, we investigated longitudinally the effect of medicaments on the indentation properties of the root canal surface of immature teeth using a novel BioDent reference point indenter. A significant difference in the majority of indentation parameters between all groups was found after one-week and one-month application of medicaments (p double antibiotic paste (DAP) > control > calcium hydroxide [Ca(OH)2]. The four-week exposure of dentin to TAP and DAP caused 43% and 31% increase in total indentation distance outcome, respectively. In the second experiment, we investigated longitudinally the effect of medicaments on the chemical structure of immature radicular dentin by measuring the phosphate/amide I ratios of dentin using Attenuated Total Reflection Fourier Transform Infrared Spectroscopy. Phosphate/amide I ratios were significantly different between the four groups after one week, two weeks and four week application of medicaments (p untreated dentin > DAP-treated dentin > TAP-treated dentin. In the third experiment, we investigated longitudinally the effect of medicaments on root fracture resistance and microhardness of radicular dentin. For the microhardness, the two-way interaction between group and time was significant (pintegrity of the superficial radicular dentin and significantly affected the indentation properties of the root canal surface. Furthermore, the three month intracanal application of medicaments significantly reduced the fracture resistance of roots.

  2. Study of contact dermatitis due to topical medicaments and cosmetics by patch testing

    Directory of Open Access Journals (Sweden)

    Vij Amit

    2007-01-01

    Full Text Available Background: Contact dermatitis is the most common immunological disorder encountered by the dermatologist and it arises when a person develops delayed type of hypersensitivity reaction to a substance coming in contact with his skin. The patch test is at present a helpful test for demonstrating contact type of allergy that identifies the cause of allergic contact dermatitis. Aim: To study the common topical medicaments and cosmetics capable of producing contact dermatitis and value of patch testing in these situations. Materials and Methods: One hundred patients suspected of having contact sensitivity to topical medicaments and common cosmetics were subjected to patch testing with the finished commercial product being used by the patient and the antigens of the Indian Standard Series and Cosmetic series kit. Results: Positivity with patch test of 96.65% was observed in patients with contact dermatitis to topical medicaments, whereas 85% of the patients with cosmetic dermatitis were tested positive. Among the cases with contact dermatitis to topical medicaments, Neomycin was tested positive in more number of patients and among the patients with cosmetic dermatitis; Kum-Kum powder and Fairness cream were tested positive in more number of patients. Conclusion: It is well known that topical medicaments are known to produce contact dermatitis; the cosmetics that are claimed to be very safe by their manufacturers do not stay much behind in doing so.

  3. The effect of carvacrol on Enterococcus faecalis as an intracanal medicament-Invitro study

    Directory of Open Access Journals (Sweden)

    Sharifian M.

    2009-08-01

    Full Text Available "nBackground and Aim: Researches have shown that bacteria play the main role in development of pulpal and periapical diseases. Chemo-mechanical cleaning of infected root-canal system can not remove all of the microorganisms. Thus interappointment medicaments are necessary to aid this goal. Calcium hydroxide is one of the most useful medicaments in root canal therapy, but this medicament can not eliminated all of the bacteria in root canal system. Carvacrol is an edible plant extract that has antimicrobial and anti-inflammatory effects. If this extract is effective against endodontic bacteria, it can be used as an root canal medicament. "nMaterials and Methods: In this experimental study, Initially, MIC and MBC of carvacrol detected with Macro broth dilution method and determined as 0.3% and 0.6%, respectively. After that, 30 single root and single canal extracted human teeth were used in this study. The number of specimens determined in a pilot study on 4 extracted teeth. After preparation to apical size # 30 with hand and rotary instruments, teeth were randomly divided into two experimental and two control groups. After culturing Enterococcus faecalis in prepared canals, we used emulsion of 0.6% carvacrol and calcium hydroxide in two A and B experimental groups for 7 days as the intracanal medicament. Microbial samples obtained before and after experiment. Then, canals with negative culture selected to obtain dentinal shaving to culture. Data obtained from microbiological samples analyzed with kruskal-wallis and Bonferroni tests. "nResults: Results of this study showed that emulsion of 0.6% carvacrol has no significant difference with calcium hydroxide in elimination enterococcus faecalis after 7 days dressing (p>0.05. "nConclusion: Carvacrol can be used as an intrappointment intracanal medicament.

  4. Variations of {sup 57}Fe hyperfine parameters in medicaments containing ferrous fumarate and ferrous sulfate

    Energy Technology Data Exchange (ETDEWEB)

    Oshtrakh, M. I., E-mail: oshtrakh@mail.utnet.ru; Novikov, E. G. [Ural Federal University (The former Ural State Technical University-UPI), Faculty of Physical Techniques and Devices for Quality Control (Russian Federation); Dubiel, S. M. [AGH University of Science and Technology, Faculty of Physics and Computer Science (Poland); Semionkin, V. A. [Ural Federal University (The former Ural State Technical University-UPI), Faculty of Physical Techniques and Devices for Quality Control (Russian Federation)

    2010-04-15

    Several commercially available medicaments containing ferrous fumarate (FeC{sub 4}H{sub 2}O{sub 4}) and ferrous sulfate (FeSO{sub 4}), as a source of ferrous iron, were studied using a high velocity resolution Moessbauer spectroscopy. A comparison of the {sup 57}Fe hyperfine parameters revealed small variations for the main components in both medicaments indicating some differences in the ferrous fumarates and ferrous sulfates. It was also found that all spectra contained additional minor components probably related to ferrous and ferric impurities or to partially modified main components.

  5. El electrón en la materia condensada

    Directory of Open Access Journals (Sweden)

    Rojo, Juan Manuel

    1997-10-01

    Full Text Available Not available.Se lleva a cabo una discusión sobre las características de los estados de los electrones en la materia condensada. Se analizan tres propiedades importantes de dichos estados: 1 el canje entre electrones, responsable del magnetismo, con énfasis en sistemas de interés actual como aglomerados pequeños y materiales amorfos; 2 el apareamiento entre electrones con una nota sobre la superconductividad a alta temperatura y 3 el túnel de electrones, mostrándose algunos ejemplos recientes de la aplicación del túnel al estudio a escala atómica de fenómenos de superficie.

  6. Effects of different intra canal medicaments on the push out bond strength of endodontic sealers

    Science.gov (United States)

    Shakouie, Sahar; Shahi, Shahriar; Samiei, Mohammad; Milani, Amin-Salem; Reyhani, Mohammad-Frough; Paksefat, Sara; Eskandarinekhad, Mahsa

    2017-01-01

    Background One of the essential properties of the root canal sealers is the adhesion to root canal dentin and their higher bond strength decreases the microleakage. The aim of the present study was to compare the effect of Different Intracanal medicaments on the push out bond strength of AH26 and MTA Fillapex sealers. Material and Methods A total of 104 one-rooted extracted human teeth were divided into 4 (n=26) experimental groups. After the cleaning and shaping, the root canals were filled with Ca(OH)2, triantibiotic paste (TAP), Metapex or 2% chlorhexidine gel for two weeks. Then, intracanal medicaments were rinsed away and the samples in the sub-groups were obturated with gutta-percha and AH26 or MTA Fillapex sealers. After two weeks incubation, 2-mm-thick middle section of each root was then subjected to push-out testing. Data were analyzed with two-way ANOVA and LSD test. Results With all the intracanal medicaments, the overall mean of bond strength values were significantly higher with AH26 compared to MTA Fillapex (pendodontic sealers was not negative. Key words:AH26, medicament, MTA Fillapex, push-out bond. PMID:28298989

  7. Chemical Composition and in Vitro Antimicrobial, Cytotoxic, and Central Nervous System Activities of the Essential Oils of Citrus medica L. cv. 'Liscia' and C. medica cv. 'Rugosa' Cultivated in Southern Italy.

    Science.gov (United States)

    Aliberti, Luigi; Caputo, Lucia; De Feo, Vincenzo; De Martino, Laura; Nazzaro, Filomena; Souza, Lucéia Fátima

    2016-09-18

    Citrus medica cv. 'liscia' and C. medica cv. 'rugosa' are two taxa of citron, belonging to the biodiversity of South Italy, in particular of Amalfi Coast, in the Campania region. The chemical composition of the essential oils (EOs) from fruit peels of both C. medica cultivars was studied by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) analyses. In all, 100 compounds were identified, 82 for C. medica cv. 'liscia', accounting for 91.4% of the total oil, and 88 for C. medica cv. 'rugosa', accounting for 92.0% of the total oil. Monoterpene hydrocarbons are the main constituents in both oils of C. medica cv. 'liscia' (79.1%) and C. medica cv. 'rugosa' (80.2%). In both oils, limonene (67.2%-62.8%) and camphene (8.5%-10.9%) are the main constituents. The antimicrobial activity of the EOs was assayed against some bacterial strains: Bacillus cereus (DSM 4313), Bacillus cereus (DSM 4384), Staphylococcus aureus (DSM 25693), Pseudomonas aeruginosa (ATCC 50071), and Escherichia coli (DSM 8579). Low concentrations of C. medica cv. 'rugosa' EO showed an inhibitory effect on P. aeruginosa and higher concentrations inhibited more B. cereus (4384) and E. coli than S. aureus. The cytotoxicity of the EO was evaluated against SH-SY5Y cell line. The influence of the EO on the expression of adenylate cyclase 1 (ADCY1) was also studied. The antimicrobial activity registered confirm their traditional uses as food preserving agents and led us to hypothesize the possible use of these oils as antimicrobials. The alterations in ADCY1 expression suggested a role for limonene in effects on the central nervous system.

  8. Chemical Composition and in Vitro Antimicrobial, Cytotoxic, and Central Nervous System Activities of the Essential Oils of Citrus medica L. cv. ‘Liscia’ and C. medica cv. ‘Rugosa’ Cultivated in Southern Italy

    Directory of Open Access Journals (Sweden)

    Luigi Aliberti

    2016-09-01

    Full Text Available Citrus medica cv. ‘liscia’ and C. medica cv. ‘rugosa’ are two taxa of citron, belonging to the biodiversity of South Italy, in particular of Amalfi Coast, in the Campania region. The chemical composition of the essential oils (EOs from fruit peels of both C. medica cultivars was studied by gas chromatography (GC and gas chromatography-mass spectrometry (GC-MS analyses. In all, 100 compounds were identified, 82 for C. medica cv. ‘liscia’, accounting for 91.4% of the total oil, and 88 for C. medica cv. ‘rugosa’, accounting for 92.0% of the total oil. Monoterpene hydrocarbons are the main constituents in both oils of C. medica cv. ‘liscia’ (79.1% and C. medica cv. ‘rugosa’ (80.2%. In both oils, limonene (67.2%–62.8% and camphene (8.5%–10.9% are the main constituents. The antimicrobial activity of the EOs was assayed against some bacterial strains: Bacillus cereus (DSM 4313, Bacillus cereus (DSM 4384, Staphylococcus aureus (DSM 25693, Pseudomonas aeruginosa (ATCC 50071, and Escherichia coli (DSM 8579. Low concentrations of C. medica cv. ‘rugosa’ EO showed an inhibitory effect on P. aeruginosa and higher concentrations inhibited more B. cereus (4384 and E. coli than S. aureus. The cytotoxicity of the EO was evaluated against SH-SY5Y cell line. The influence of the EO on the expression of adenylate cyclase 1 (ADCY1 was also studied. The antimicrobial activity registered confirm their traditional uses as food preserving agents and led us to hypothesize the possible use of these oils as antimicrobials. The alterations in ADCY1 expression suggested a role for limonene in effects on the central nervous system.

  9. De las nulidades contractuales y el arbitramento en materia administrativa

    Directory of Open Access Journals (Sweden)

    Jesús David Orozco Vanegas

    2003-01-01

    Full Text Available Cuando en un contrato se pacta la cláusula compromisoria, entendemos que las partes sustraen de la competencia del conocimiento de lajusticia (ordinaria o administrativa la resolución de los eventuales conflictos que surjan de la interpretación, ejecución o liquidación del mismo. En el caso de la contratación administrativa, la ley autoriza expresamente su implementación, pero no puede entenderse que ésta es absoluta, y por el contrario, es necesario establecer límites a su aplicación, ya que no se puede olvidar que en este caso una de las partes contratantes es el Estado, que tiene ciertas prerrogativas y facultades que le son propias a su calidad, en las cuales se compromete el orden jurídico y el ejercicio del poder público, M aspectos sobre los cuales no se puede disponer. En este ensayo se abordan sólo algunos de los aspectos e inconvenientes que tiene el arbitramento en materia Adminis- trativa, sobre todo en los casos en que se discute sobre los vicios o defectos del contrato como acto jurídico

  10. Gratis toegang tot duizenden uren fim-en tv-materiaal

    NARCIS (Netherlands)

    Westera, Wim

    2009-01-01

    Westera, W. (2008). Gratis toegang tot duizenden uren film- en tv-materiaal. Presentatie gehouden voor op de Onderwijsdag van de Open Universiteit Nederland. December, 4, 2008, Heerlen, Nederland: Open Universiteit Nederland.

  11. La legislación más relevante en materia de adicciones

    OpenAIRE

    Cobas Cobiella, María Elena

    2005-01-01

    El presente trabajo tiene como objetivo, exponer sucintamente, y acotada cronológicamente, la legislación más destacada en materia de adicción, con especial referencia al alcoholismo, tabaquismo y drogas. Igualmente se expondrán aquellos elementos comunes y principios que identifica la legislación estatal, y las legislacio­nes autonómicas en la materia.

  12. Comparison of antibacterial efficacy of intracanal medicaments in multiple visit pulpectomies in primary molars-an in vivo study

    Directory of Open Access Journals (Sweden)

    Lele G

    2010-03-01

    Full Text Available Antibacterial efficacy of formocresol, 2% gluteraldehyde and iodine-potassium iodide was assessed by obtaining cultures at consecutive appointments in multiple visit pulpectomies in primary molars. Formocresol and 2% gluteraldehyde were more effective as intracanal medicaments and caused significant reduction in the counts of aerobic and anaerobic microorganisms, thereby supporting the need for placing intracanal medicaments with antibacterial properties, in multiple visit pulpectomies in primary molars.

  13. Antimicrobial Activity of Endodontic Medicaments and Vehicles using Agar Well Diffusion Method on Facultative and Obligate Anaerobes

    Science.gov (United States)

    Bhat, Kishore G; Sogi, Suma

    2016-01-01

    Aims The aim of this study was to determine the relative antimicrobial effectiveness of these endodontic medicaments and various vehicles using an agar well diffusion assay. Materials and methods Double Antibiotic Paste(DAP), modified DAP, 2% Chlorhexidine gluconate and their combination with four vehicles namely Polyethylene glycol 400 (PEG), Propylene glycol (PG), combinations of PG with PEG and lastly Glycerine were tested using agar well diffusion assay. The minimum bactericidal concentration was noted against four standard strains of organisms ie Streptococcus mutans ATCC( American Type Culture Collection) 25175, Staphylococcus aureus ATCC 12598, Enterococcus faecalis ATCC 35550 and Eschericia coli ATCC 25922. Successful endodontic therapy depends upon thorough disinfection of root canals. In some refractory cases, routine endodontic therapy is not sufficient, so intracanal medicaments are used for proper disinfection of canals. Issues of resistance, limited spectrum of activity and lack of antifungal properties, the hunt for the ideal intracanal medicament continues. In this regard, the vehicles used to form the pastes play a supportive role by forming the appropriate consistency for placement and may dramatically influence their chemical characteristics like their solubility and diffusion. Thus, inorder to use safer and equally effective intracanal medicaments, Chlorhexidine gluconate is being unveiled in this study. Results The difference between the four vehicles when combined with the same endodontic medicament studied above is nonsignificant (NS) except against Porphyromonas gingivalis. Propylene glycol is significantly effective than Glycerine when used with DAP ie C+M medicament combination. (p = 0.029) Conclusion 2% chlorhexidine gluconate and modified DAP can definitely replace DAP and triple antibiotic paste as end-odontic medicaments with chlorhexidine having an added advantage of bactericidal action, substantivity, biocompatibility, low toxicity

  14. Endodontic 'solutions' part 1: a literature review on the use of endodontic lubricants, irrigants and medicaments.

    Science.gov (United States)

    Good, Melissa; El, Karim Ikhlas A; Hussey, David L

    2012-05-01

    Endodontic lubricants, irrigants and medicaments help prepare and disinfect root canal systems (RCS) but primary and secondary cases involve different microbes and therefore it is unlikely that one protocol will be effective for both case types. Each individual 'solution' or sequence of'solutions' could play a significant role in each case type, but there are no detailed published guidelines in existence. To help inform clinical practice it was decided to undertake a literature review followed by a UK and Republic of Ireland wide audit on current endodontic'solution' usage within dental schools. The literature review was undertaken under the following headings: pre-op oral rinse; file lubricants; root canal irrigants and intracanal medicaments and provides an evidence base for protocol development for both primary and retreatment cases.The audit project and the protocols developed from the findings of both the literature review and audit will be presented in Part 2.

  15. Culture Technology of Citrus medica var.sarcodactylis%佛手丰产栽培技术

    Institute of Scientific and Technical Information of China (English)

    邹文武; 朱雯

    2014-01-01

    文章介绍了佛手的生物学特性、种苗繁育、栽植技术和主要病虫害防治等,为佛手栽培种植提供技术指导。%Cultrue technology of Citrus medica var.sarcodactylis was introduced in this article,which in-cluding technology in seedling breeding,planting and method of main disease and pest control.

  16. Physicochemical Properties and Fungitoxicity of the Essential Oil of Citrus medica L. against Groundnut Storage Fungi

    OpenAIRE

    2008-01-01

    The in vitro antifungal effect of the essential oil of Citrus medica L. on storage fungi of Arachis hypogea L. stored for 6 months was evaluated using the disc diffusion agar method. The oil exhibited a wide spectrum of fungitoxicity, inhibiting all 14 fungus species tested. Thus, the oil can be exploited as a fumigant against storage fungi for the preservation of stored legume seeds due to its wide range of activity, non-phytotoxicity, and long-term persistence of fungitoxicity.

  17. Yeast α-Glucosidase Inhibitory Phenolic Compounds Isolated from Gynura medica Leaf

    Directory of Open Access Journals (Sweden)

    Chao Tan

    2013-01-01

    Full Text Available Gynura medica leaf extract contains significant amounts of flavonols and phenolic acids and exhibits powerful hypoglycemic activity against diabetic rats in vivo. However, the hypoglycemic active constituents that exist in the plant have not been fully elaborated. The purpose of this study is to isolate and elaborate the hypoglycemic activity compounds against inhibition the yeast α-glucosidase in vitro. Seven phenolic compounds including five flavonols and two phenolic acids were isolated from the leaf of G. medica. Their structures were identified by the extensive NMR and mass spectral analyses as: kaempferol (1, quercetin (2, kaempferol-3-O-β-D-glucopyranoside (3, kaempferol-3-O-rutinoside (4, rutin (5, chlorogenic acid (6 and 3,5-dicaffeoylquinic acid methyl ester (7. All of the compounds except 1 and 3 were isolated for the first time from G. medica. Compounds 1–7 were also assayed for their hypoglycemic activity against yeast α-glucosidase in vitro. All of the compounds except 1 and 6 showed good yeast α-glucosidase inhibitory activity with the IC50 values of 1.67 mg/mL, 1.46 mg/mL, 0.38 mg/mL, 0.10 mg/mL and 0.53 mg/mL, respectively.

  18. Effects of Chinese herbs on multiple ion channels in isolated ventricular myocytes

    Institute of Scientific and Technical Information of China (English)

    LI Ning; MA Ke-juan; WU Xiang-feng; SUN Qi; ZHANG Yi-hui; PU Jie-lin

    2007-01-01

    Background Shensong Yangxin (SSYX) is one of the compound recipe of Chinese materia medica. This study was conducted to investigate the effects of SSYX on sodium current (INa), L-type calcium current (ICa,L), transient outward potassium current (Ito), delayed rectifier current (IK), and inward rectifier potassium currents (IK1) in isolated ventricular myocytes.Methods Whole cell patch-clamp technique was used to study ion channel currents in enzymatically isolated guinea pig or rat ventricular myocytes.Results SSYX decreased peak INa by (44.84±7.65)% from 27.21±5.35 to 14.88±2.75 pA/pF (n=5, P<0.05). The medicine significantly inhibited the ICa,L. At concentrations of 0.25, 0.50, and 1.00 g/100 mi, the peak ICa,L was reduced by(19.22±1.10)%, (44.82±6.50)% and (50.69±5.64)%, respectively (n=5, all P<0.05). SSYX lifted the Ⅰ-Ⅴ curve of both INa and ICa,L without changing the threshold, peak and reversal potentials. At the concentration of 0.5%, the drug blocked the transient component of Ito by 50.60% at membrane voltage of 60 mV and negatively shifted the inactive curve and delayed the recovery from channel inactivation. The tail current density of IK was decreased by (30.77±1.11)% (n=5,P<0.05) at membrane voltage of 50 mV after exposure to the medicine and the time-dependent activity of IK was also inhibited. Similar to the effect on IK, the SSYX inhibited IK1 by 33.10% at the test potential of -100 mV with little effect on reversal potential and the rectification property.Conclusions The experiments revealed that SSYX could block multiple ion channels such as INa ICa,L, Ik, Ito and IK1,which may change the action potential duration and contribute to some of its antiarrhythmic effects.

  19. La pericia medico-legal en materia penal juvenil

    Directory of Open Access Journals (Sweden)

    Ronald Salazar Murillo

    1999-09-01

    Full Text Available La reforma recién ocurrida en materia penal juvenil en Costa Rica reconoce al menor su personalidad jur{idica, le hace justicia, le otorga responsabilidad por sus acciones, para lo cual se ha diseñado un Sistema Penal Juvenil de fin pedagógico, educativo y formativo delmenor infractor y por ello puede ser objeto de peritación médicolegal, pericias físicas sobre su cuerpo y exámenes psicosociales. Interesa en la pericia f{isica establecer laedad del menor, especialmente en un país de alta inmigración indocumentada comoel nuestro donde diferencias de tan solo un mes pueden producir la aplicación o no de la Ley. Toda pericia debe respeta el pudor, evitar la revictimización y ser realizada por peritos forenses deseablemente. Es de interés también la constatación de la capacidad de culpabilidad, el grado de desarrollo y responsabiliadad de dirigir sus acciones e ilustrar al Juez y a las partes aacerca de las eventuales sanciones a imponer.The new reformation made in the Costa Rican Juvenile Law recognizes the legal personality of the minor, it makes him justice and gives him more responsability for his actions .For all these it has been design a Juvenile Law System with pedagogic, educative and formative ends for the minor transgressor , therefore it can be the object of medico-legal expertize, physical aspects like his body, his tests and psicoanalisis. The porpouse of physical expertize is to establish the age of the minor specially in a high undocumented migration country like ours, where differences of only a months can produce the aplication or not of the law. All the expertizes must respect the dignity, avoid the victimazation once again and be done by forensic experts by their own will. It is also important in medico-legal expertize the constation of capacity of guiltiness, the degree of development and responsability to direct their actions , and ilustrate to the judge and the parties, about the eventuals sanctions to impone.

  20. Identification of Sinorhizobium (Ensifer) medicae based on a specific genomic sequence unveiled by M13-PCR fingerprinting.

    Science.gov (United States)

    Dourado, Ana Catarina; Alves, Paula I L; Tenreiro, Tania; Ferreira, Eugénio M; Tenreiro, Rogério; Fareleira, Paula; Crespo, M Teresa Barreto

    2009-12-01

    A collection of nodule isolates from Medicago polymorpha obtained from southern and central Portugal was evaluated by M13-PCR fingerprinting and hierarchical cluster analysis. Several genomic clusters were obtained which, by 16S rRNA gene sequencing of selected representatives, were shown to be associated with particular taxonomic groups of rhizobia and other soil bacteria. The method provided a clear separation between rhizobia and co-isolated non-symbiotic soil contaminants. Ten M13-PCR groups were assigned to Sinorhizobium (Ensifer) medicae and included all isolates responsible for the formation of nitrogen-fixing nodules upon re-inoculation of M. polymorpha test-plants. In addition, enterobacterial repetitive intergenic consensus (ERIC)-PCR fingerprinting indicated a high genomic heterogeneity within the major M13- PCR clusters of S. medicae isolates. Based on nucleotide sequence data of an M13-PCR amplicon of ca. 1500 bp, observed only in S. medicae isolates and spanning locus Smed_3707 to Smed_3709 from the pSMED01 plasmid sequence of S. medicae WSM419 genome's sequence, a pair of PCR primers was designed and used for direct PCR amplification of a 1399-bp sequence within this fragment. Additional in silico and in vitro experiments, as well as phylogenetic analysis, confirmed the specificity of this primer combination and therefore the reliability of this approach in the prompt identification of S. medicae isolates and their distinction from other soil bacteria.

  1. de distribución de materia orgánica

    Directory of Open Access Journals (Sweden)

    Tomasa Rodríguez Hernández

    2007-01-01

    Full Text Available En el presente trabajo se analizan los costos de explotación del sistema mecanizado de distribución de materia orgánica, para diferentes combinaciones del conjunto distribuidor y transporte (denominado coeficiente de serviciaje. Se modeló analíticamente el proceso tecnológico mediante el sistema automatizado «SMDMO», determinándose los costos horarios (peso/h y por unidad de área trabajada (peso/ha, contemplando los costos por concepto de salario, amortización, reparación - mantenimientos, combustible y materia orgánica. Los resultados brindaron que los menores costos por unidad de área se obtuvieron para un coeficiente de serviciaje de 0,8 con 75,76 peso/ha, siendo los costos horarios dependientes en gran medida de lo gastado por concepto de materia orgánica

  2. Populismo Punitivo y ejecución en materia penal juvenil en Costa Rica

    OpenAIRE

    Burgos, Álvaro

    2014-01-01

    El presente artículo desarrolla, en primer lugar, la problemática de la desigualdad social como antesala del aumento de la violencia y el delito, y dentro de este contexto, la situación de vulnerabilidad de la población menor de edad. Se analiza el impacto del llamado populismo punitivo sobre la materia penal juvenil, y se advierte sobre la necesidad de la prevención del delito por encima de su represión, más aún en esta materia, donde deben primar principios reconocidos en importantes instru...

  3. Medical Business Ethics in the XXI century; Deontologia medica del siglo XXI

    Energy Technology Data Exchange (ETDEWEB)

    Moya Pueyo, V.

    2009-07-01

    Since ancient times the medical professional practice included moral rules in order to assure a correct approach of capital problems. These rules evolve and are now gathered in the Deontological Codes watching the Constitution and other higher Laws. There has been an increase of interest for none strictly clinical matter since the appearance of the term Bioethics. The book Deontologia medica en el siglo XXI tackles problems of first interest in the present times, thru statistics and analysis, trying to help the medical doctors that have to take ethic decisions. (Author)

  4. Mente e Materia. Fisiologia dell'anima nella tradizione galenica tardo-rinascimentale (1575-1625)

    OpenAIRE

    Bigotti, Fabrizio

    2012-01-01

    La tesi si sviluppa intorno alla diffusione ed alla tradizione del trattato galenico Quod animi mores nell'età tardo Rinascimentale. Dalla derivazione fisiologica degli stati psichici e delle scelte morali alla teoria degli elementi ed alla fisiognomica medica, il trattato di Galeno rappresenta l'esempio di un testo chiave della discussione scientifica e culturale della prima età moderna. Intorno a problemi da esso sollevati ruotano, infatti, le principali tesi dei medici e filosofi sulla nat...

  5. [Hypochondria sine materia as a psychosomatic problem: a model of hypochondriac disorders realized in the cutaneous sphere].

    Science.gov (United States)

    Smulevich, A B; Dorozhenok, I Iu; Romanov, D V; L'vov, A N

    2012-01-01

    Hypochondria sine materia is a disorder with physical complains corresponding to no any somatic diagnosis. Hypochondria sine materia is a more complicated psychopathological condition compared to hypochondria cum materia. Hypochondria sine materia could be diagnosed not only in psychiatry, but mainly in general medicine. It is especially prevalent in dermatology. As a result of analysis of hypochondriac disorders involving cutaneous sphere in patients without dermatological diseases, a binary model of psychodermatological syndromes presenting with hypochondria sine materia in dermatology was developed. The binary structure of the psychodermatological syndromes includes secondary psychiatric symptoms based on primary coenesthesiopathic phenomena. The heterogeneous psychodermatological syndromes (cutaneous organ neurosis, impulsive excoriations syndrome, circumscripta hypochondria, coenesthesiopathic paranoia) could be arranged in a continuum of consecutively worsening conditions from neurotic to psychotic severity register. The syndromes differ in clinical and social prognosis requiring different approach to diagnosis and treatment.

  6. Pectin extraction from Citron peel (Citrus medica Linn. and its use in food system

    Directory of Open Access Journals (Sweden)

    Rojanakorn, T.

    2006-11-01

    Full Text Available Screening experiments using 25-1 fractional factorial design showed that pH, temperature, and extracting time were the main factors affecting the amount and quality of extracted pectin from Citrus medica Linn. Optimum condition of pectin extraction was studied using central composite design (CCD. Mathematical models relating pH, temperature and extracted time to amount of extracted pectin, equivalent weight, methyl content and anhydrogalacturonic acid content were established. Based on the mathematics models, the condition of pH 2, 100ºC and 105 min was found to be the optimum conditions for pectin extraction from Citrus medica Linn. Mathematical and experimental results were verified. The use of extracted pectin as a gelling agent in pineapple jam revealed no significant difference in gel consistency compared to that of commercial pectin grade 150 (p>0.05. However, the commercial pectin had a higher liking score on the spreadability, texture and overall liking. As a stabilizer in chocolate pasteurised milk, 0.2% of the extracted pectin was required to prevent precipitation of chocolate powder with the similar viscosity obtained from 0.06% κ-carageenan

  7. Growth inhibition of Struvite crystals in the presence of juice of Citrus medica Linn.

    Science.gov (United States)

    Chauhan, C K; Joshi, M J

    2008-10-01

    Struvite, one of the components of urinary stone grows rapidly forming "staghorn-calculi", is a painful urological disorder. It is necessary to study the growth-inhibition of Struvite crystals. This in vitro study has been carried out in the presence of the juice of Citrus medica Linn. by using single diffusion gel growth technique. Sodium metasilicate solution of specific gravity 1.05 and an aqueous solution of ammonium dihydrogen phosphate of 0.5 M concentration were mixed so that the pH value 7.0 could be set. After the gelation, supernatant solutions comprising of pure 1.0 M Magnesium acetate (control solution) as well as mixed with the different concentrations of the juice were gently poured on the set gels. From the study of growth-inhibition behavior of Struvite crystals, it was found that Citrus medica Linn. inhibits the growth of the crystals. This study may be used for formulating the strategy for prevention or dissolution of Struvite.

  8. A Traditional Chinese Medicine Research on the Principal Antidepressive Effect in Kaixin Jieyu Prescription Based on Uniform Distribution%基于均匀设计的开心解郁方抗抑郁主效应中药筛选研究

    Institute of Scientific and Technical Information of China (English)

    潘菊华; 郑军; 王彦云; 雷小明; 李多娇; 陈朝; 黄世敬

    2014-01-01

    目的:筛选开心解郁方中抗抑郁的主效应中药。方法采用 U11(1110)均匀设计表和使用表,将开心解郁方(人参、巴戟天、赤芍、远志、柴胡、枳实)设成11个剂量配伍组,加上阳性药组(地西泮)和阴性对照组,共13组,实验小鼠按体质量随机分组。连续给药14 d 后分别进行悬尾实验、强迫游泳实验和自主活动实验。结果以悬尾测试的不动时间百分比(Y1)为因变量,以 X1~X6为自变量,拟合多元非线性回归分析,Y1=1.1331-0.8423×X1+0.4382×X3-0.7129×X6,提示人参、枳实具有明显抗抑郁作用;赤芍具有促进抑郁的作用。以强迫游泳的不动时间(Y2)为因变量,以 X1~X6为自变量拟合多元非线性回归分析,Y2=167.69-2.99×X12-2.14×X1-1.65×X6,提示人参、枳实具有明显的抗抑郁作用。小鼠自主活动测试显示,X1~X6对小鼠自主活动指数(Y3)无显著影响,提示开心解郁方的抗抑郁作用与中枢兴奋性无关。结论人参和枳实是开心解郁方中抗抑郁的主效应中药。%Objective To pick up the Chinese materia medica with principal antidepressive effect in Kaixin Jieyu prescription based on uniform distribution. Methods 11 groups of concerted application with different dosages of six simplex Chinese materia medica (X 1-X 6) of Kaixin Jieyu prescription were arranged by the designlist and sustentacular table of U11(1110). Positive and negative control groups were also formed. Mice were randomized into 13 groups according to body weight and fed with medicine 14 d and estimated by tail suspension test, forced swim test and autonomic activities test. Results Relationship of percentage of immovability time (Y 1) in the tail suspension test and X 1-X 6 were analyzed with multivariant non-linear regression analysis and resulted in Y 1=1.133 1-0.842 3×X 1+0.438 2×X 3-0.712 9×X 6. It indicated that both Radix Ginseng and Fructus Aurantii Immaturus had obvious

  9. I “bancomat” vaticani e la nuova “questione romana” in materia finanziaria

    Directory of Open Access Journals (Sweden)

    Antonio Fuccillo

    2013-02-01

    Full Text Available Contributo sottoposto a valutazioneSOMMARIO: 1. La recente vicenda dei “bancomat” vaticani bloccati dalla Procura della Repubblica di Roma - 2. Trasparenza finanziaria Vs. indipendenza della Santa Sede - 3. La normativa in materia di misure per il contrasto al riciclaggio e i riflessi sulla libertà religiosa dei fedeli nello Stato Città del Vaticano.

  10. Los frutos de las cactáceas y su potencial como materia prima

    OpenAIRE

    Patricia Esquivel

    2004-01-01

    Los frutos de las Cactáceas y su potencial como materia prima. Se presenta información sobre las características generales, así como usos actuales y potenciales de los miembros más importantes, desde un punto de vista comercial, de la familia de las cactáceas.

  11. de distribución de materia orgánica

    Directory of Open Access Journals (Sweden)

    Héctor Rafael de las Cuevas Milán

    2007-01-01

    Full Text Available En el trabajo se fundamentan teóricamente los indicadores de explotación en el sistema mecanizado de distribución de materia orgánica, brindándose resultados de aplicación real.

  12. Evaluation and comparison of white mineral trioxide aggregate and formocresol medicaments in primary tooth pulpotomy: Clinical and radiographic study

    Directory of Open Access Journals (Sweden)

    Cheranjeevi Jayam

    2014-01-01

    Full Text Available Aim: The primary aim of the following study is to evaluate and secondary aim is to compare clinically and radiographically the success of using white mineral trioxide aggregate (MTA versus formocresol (FC medicament for primary tooth pulpotomy. Materials and Methods: A total of 100 teeth were selected for pulpotomy; of which 50 teeth underwent FC pulpotomy and 50 teeth underwent pulpotomy with white MTA. Out of 100 treated teeth, 82 teeth (42 FC and 40 MTA teeth were available at the end of 24 months for evaluation. 4 failures were found in FC group at 1 st month evaluation and no failures were found in white MTA group. A statistical analysis was performed to evaluate the overall success rate of study and individual success rates of medicaments. Overall success rate of the study was 95%, success rate of FC group was 90.48% and success rate of MTA group was 100%. Results: MTA produced better results as pulpotomy medicament in comparison to FC. The superior success obtained in the present study was matching other studies mentioned in the literature. Conclusion: MTA seems to be a promising pulpotomy medicament for future use.

  13. Experimental studies on radioprotection of the bladder wall by means of medicaments (experiments on 17 female domestic cats)

    Energy Technology Data Exchange (ETDEWEB)

    Pust, R.; Weidner, W.; Rothauge, C.F.; Ernst, H.

    1982-11-01

    The radioprotective effect of Cortisone, Bepanthen and Actihaemyl during a telecobalt irradiation of the bladder with a focal dose of 60 Gy was investigated in 17 female domestic cats. Different clinical and radiological and especially focally shaped modifications were caused by the administration of these medicaments. The modifications are discussed in detail.

  14. Comparison of Endodontic Medicaments on Bond Strength of Fiber Post to Root Dentin Using Resin Cement

    Directory of Open Access Journals (Sweden)

    Maryam Zare Jahromi

    2017-03-01

    Full Text Available Statement of the Problem: Endodontic irrigants and medicaments may affect the bond strength of intracanal posts to root dentin. Purpose: The aim of this study was to compare the effect of calcium hydroxide (Ca(OH2 and 2% chlorhexidine gel (CHX on bond strength of fiber post cemented with resin cement to root dentin. Materials and Method: This in vitro experimental study was conducted on 36 mandibular premolars. Canals were prepared using the step back technique. After root canal irrigation, the teeth were divided into three groups of 12. Ca(OH2 paste and CHX gel were used as intracanal medicaments in the first and second groups respectively. No intracanal medicament was used in the third group (control group. Access cavities were then sealed and the teeth were incubated for one week. The root canals were then filled using gutta percha and AH26 sealer and the teeth were incubated for 72 hours. Tooth crowns were then cut at the level of the cementoenamel junction and intracanal posts were placed. The teeth were mounted in auto-polymerizing acrylic resin, and incubated for one week .They were then sectioned into 1.5mm thick slices from their coronal surface using a fully automated cutting machine, and subjected to push-out test until failure. The load at debonding was recorded and data were analyzed using one-way ANOVA, post-hoc test and t-test. The coronal margin of the root was at the level of the surface of acrylic resin in the mold. Results: The mean bond strength was 4.45 MPa in the Ca(OH2, 2.45 MPa in the CHX and 2.48 MPa in the control group. The difference in this regard was statistically significant among groups (p= 0.04. The Ca(OH2 group had significant differences with the CHX and control groups (p= 0.03 and p= 0.02, respectively. The difference between the CHX and control groups was not significant (p= 0.974. Conclusion: Based on the results, Ca(OH2 increased the bond strength of fiber post to root dentin but 2% CHX had no effect on

  15. Comparison of Endodontic Medicaments on Bond Strength of Fiber Post to Root Dentin Using Resin Cement

    Science.gov (United States)

    Zare Jahromi, Maryam; Barekatain, Mehrdad; Ravanbod, Shirin; Ranjbarian, Parisa; Kousehlar, Sara

    2017-01-01

    Statement of the Problem: Endodontic irrigants and medicaments may affect the bond strength of intracanal posts to root dentin. Purpose: The aim of this study was to compare the effect of calcium hydroxide (Ca(OH)2) and 2% chlorhexidine gel (CHX) on bond strength of fiber post cemented with resin cement to root dentin. Materials and Method: This in vitro experimental study was conducted on 36 mandibular premolars. Canals were prepared using the step back technique. After root canal irrigation, the teeth were divided into three groups of 12. Ca(OH)2 paste and CHX gel were used as intracanal medicaments in the first and second groups respectively. No intracanal medicament was used in the third group (control group). Access cavities were then sealed and the teeth were incubated for one week. The root canals were then filled using gutta percha and AH26 sealer and the teeth were incubated for 72 hours. Tooth crowns were then cut at the level of the cementoenamel junction and intracanal posts were placed. The teeth were mounted in auto-polymerizing acrylic resin, and incubated for one week .They were then sectioned into 1.5mm thick slices from their coronal surface using a fully automated cutting machine, and subjected to push-out test until failure. The load at debonding was recorded and data were analyzed using one-way ANOVA, post-hoc test and t-test. The coronal margin of the root was at the level of the surface of acrylic resin in the mold. Results: The mean bond strength was 4.45 MPa in the Ca(OH)2, 2.45 MPa in the CHX and 2.48 MPa in the control group. The difference in this regard was statistically significant among groups (p= 0.04). The Ca(OH)2 group had significant differences with the CHX and control groups (p= 0.03 and p= 0.02, respectively). The difference between the CHX and control groups was not significant (p= 0.974). Conclusion: Based on the results, Ca(OH)2 increased the bond strength of fiber post to root dentin but 2% CHX had no effect on bond

  16. Survey of Current Experimental Studies of Effects of Traditional Chinese Medicine on Peripheral Nerve Regeneration

    Institute of Scientific and Technical Information of China (English)

    WU Qun-li; LIANG Xiao-chun

    2006-01-01

    The repairing and regeneration of peripheral nerves is a very complex biological and cytological process, its mechanism is unclear so far, and thus results in the lack of specific and effectual therapy and medicament. Chinese herbs and their effective components have their own inimitable predominance in promoting peripheral nerve regeneration, such as their multi-factorial, multi-target and multi-functional action, abundant source, inexpensive, etc. In this paper, the experimental studies reported in recent 5 years concerning the effects of Chinese herbs or their active components on peripheral nerve repairing and regeneration are reviewed in respects of the integral level, cellular level, molecular level and gene level.

  17. Information for Authors

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    1 General Asian Journal ofAndrology (AJA) is the official publication of the Asian Society of Andrology sponsored by the Shanghai Institute of Materia Medica,Chinese Academy of Sciences.The Journal has been included in 11 international indexing systems,including BIOSIS,CAB Abstracts,CAB Health,Chemical Abstracts,Current Contents/

  18. 酶反应提取技术在中药化学成分提取中的应用%Application Progress on Enzymatic Extraction Technology in Extraction of Chemical Compositions of Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    王忠雷; 杨丽燕; 曾祥伟; 李朋收; 张小华

    2013-01-01

    酶反应提取技术(生物酶解提取技术)是利用酶反应所具有高度专一性的特点,通过适当的酶选择性地破坏植物细胞壁,使植物细胞内的成分更容易溶解、扩散的原理而应用于中药有效成分提取的新技术.该技术不但具有条件温和、易除杂质、节约能耗、浸出率高、设备简易、减少热敏成分降解等优势,而且具有应用于大规模工业化生产的潜力.其应用前景十分广阔,已经广泛用于中药多糖类、生物碱类、黄酮类、皂苷类、蛋白质类、有机酸类等成分的提取.我们就该技术的应用进展及方法特点做一系统性概述,以期新技术能够更加合理而有效的应用于中药化学成分的提取.%Enzymatic extraction technology is based on the highly specific feature of enzyme, which is used to destroy the plant cell wall selectively, making active components inside plant cell more easily to dissolve and spread. Based on the above principle, this new technique is being broadly used in the aspects of TCMs extraction. This technology not only has the advantage of mild conditions、removing impurity easily、saving energy consumption、ratio high leaching、simple equipment and reducing degradation of thermal ingredient, but also has the potential of large — scale industrial production. It has been widely used in the extraction of chemical compositions of Chinese medicine,including polysaccharides、alkaloids、flavonoids、saponins、proteins、organic acids,et al. This article has made a systematic exposition to this technology' s application progress and method characteristics,so as to make new technology can be more reasonable and effective in active components extraction of Chinese Materia Medica.

  19. Studies of beneficial interactions between active medicaments and excipients in pharmaceutical formulations.

    Science.gov (United States)

    Kalinkova, G N

    1999-09-30

    A review of "up to date" research findings leading to new concepts of the pharmaceutical formulations and their interactions has been presented. The rational approaches to the excipients choice as well as to their interactions with medicaments have been shown as a basis for modern modelling of pharmaceutical formulations. The importance of complexation, hydrogen bonding, ion-dipole, dipole-dipole and van der Waals attractions as the tools which can modify the physicochemical, pharmacological or pharmacokinetical behaviour of the medicaments has been emphasised. In vivo studies (carried out in healthy human subjects-volunteers, in beagle dogs, in rats etc.) and in vitro studies (on excised human skin, hairless mouse skin etc.) as well as studies of chemical stability and bioavailability serve also as a proof of these interactions. Therefore, excipients are important components of pharmaceutical formulations and they can take an active part in the improvement of the characteristics of formulations (but they may also reduce the effectiveness of some preparations). In this context, the so called active and inactive ingredients in pharmaceutical formulations are inexact, old and "out-of date". Their further use is only conventional. In conclusion, among the various modern techniques applied the combination of infrared spectroscopy and X-ray diffraction has been estimated as the most successful in proving the interactions between drugs and excipients. Finally, pharmaceutical formulations and their interactions have constituted a diverse and rapidly expanding field of Pharmacy (Pharmaceutical Technology, Pharmaceutical Industry and Pharmaceutical Sciences) which covers a wide range of numerical topics within an unified framework.

  20. Population genomics of the facultatively mutualistic bacteria Sinorhizobium meliloti and S. medicae.

    Science.gov (United States)

    Epstein, Brendan; Branca, Antoine; Mudge, Joann; Bharti, Arvind K; Briskine, Roman; Farmer, Andrew D; Sugawara, Masayuki; Young, Nevin D; Sadowsky, Michael J; Tiffin, Peter

    2012-01-01

    The symbiosis between rhizobial bacteria and legume plants has served as a model for investigating the genetics of nitrogen fixation and the evolution of facultative mutualism. We used deep sequence coverage (>100×) to characterize genomic diversity at the nucleotide level among 12 Sinorhizobium medicae and 32 S. meliloti strains. Although these species are closely related and share host plants, based on the ratio of shared polymorphisms to fixed differences we found that horizontal gene transfer (HGT) between these species was confined almost exclusively to plasmid genes. Three multi-genic regions that show the strongest evidence of HGT harbor genes directly involved in establishing or maintaining the mutualism with host plants. In both species, nucleotide diversity is 1.5-2.5 times greater on the plasmids than chromosomes. Interestingly, nucleotide diversity in S. meliloti but not S. medicae is highly structured along the chromosome - with mean diversity (θ(π)) on one half of the chromosome five times greater than mean diversity on the other half. Based on the ratio of plasmid to chromosome diversity, this appears to be due to severely reduced diversity on the chromosome half with less diversity, which is consistent with extensive hitchhiking along with a selective sweep. Frequency-spectrum based tests identified 82 genes with a signature of adaptive evolution in one species or another but none of the genes were identified in both species. Based upon available functional information, several genes identified as targets of selection are likely to alter the symbiosis with the host plant, making them attractive targets for further functional characterization.

  1. Condensación de Bose-Einstein. El quinto estado de la materia

    Directory of Open Access Journals (Sweden)

    Gloria Peñaloza

    2006-01-01

    Full Text Available Se presenta una introducción al fenómeno sorprendente de condensación de la materia a temperaturas cercanas al cero absoluto. Este fenómeno está basado en los fundamentos cuánticos de la materia. Sus principales descubridores teóricos fueron S.Bose y A. Einstein. Se inicia con un poco de historia, para luego analizar el comportamiento físico del problema. Posteriormente se abordan algunos aspectos relevantes de sus aplicaciones tecnológicas, apartir de los resultados de investigación de los grupos enbezados por Eric Cornell (NIST, Carl Wieman (Universidad de Colorado y Wolfgang Ketterle (MIT.

  2. Caracterización de algunas materias primas nacionales empleadas en alimentos para animales

    Directory of Open Access Journals (Sweden)

    Alvaro E. Obando R.

    2009-07-01

    Full Text Available El objeto de este trabajo fue desarrollar especificaciones y normalizar la nomenclatura de las materias primas colombianas más utilizadas en la fabricación de alimentos concentrados para animales. Se estudiaron los siguientes productos básicos: arroz , sorgo, maíz, trigo y torta de soya, con sus respectivos subproductos, los cuales constituyen el 84% del volumen de demanda. El muestreo, efectuado a nivel nacional, comprendió 55 fabricas que representan cerca de un 90% de la producción nacional. Las especificaciones se hicieron con base en el análisis proximal incluyendo el 99.7% de la población, (X±3S. Se optimizó ei tamaño muestral utilizando un sistema estadístico secuencial. Algunas materias primas son reportadas por primera vez.

  3. 《本草纲目》中有关植物果实与鸟类之间的生态关系%A preliminary study on ecological relationship between fruits and birds found in Compendium of Materia Medica

    Institute of Scientific and Technical Information of China (English)

    李新华

    2004-01-01

    李时珍的是我国古代伟大的本草学巨著,该书除了在中医药学、药用植物学、本草考证等方面的杰出成就外,在生态学方面也提供了许多有价值的科学资料.考察了中有关鸟类对梧桐(Firmiana simplex)、楝(Melia azedarach)和乌桕(Sapium sebiferum)等9种植物果实的取食作用,以及鸟类取食果实对植物的影响等内容记载,并结合现代研究资料,分析了有关植物果实与鸟类之间的生态关系.

  4. [Deciphering the argots of the names of materia medica and its dosage in the Yi lin kou pu liu zhi mi shu (A Secret Medical Book of Six Therapies in Rhymes of Medical Professionals)].

    Science.gov (United States)

    Zhou, Jian; Lin, Shiyi; Liu, Shijue

    2014-11-01

    Yi lin kou pu liu zhi mi shu (A Secret Medical Book of Six Therapies in Rhymes of Medical Professionals) was additionally compiled, supplemented and annotated by Zhou Sheng, a famous doctor of the Qing Dynasty, based on Yi lin kou pu (Rhymes of Medical Professionals) which was composed by Lu Qi. The book contains four volumes in total, dealing mainly with the miscellaneous diseases of internal medicine, as well as external medicine, gynecology, and pediatrics etc. The syndrome differentiation and treatment, prescriptions and medications in this book has its own characteristic with rather high academic value and practical significance. There were 20 drug names were deciphered by the argots, for instance, "you che" was the argot of golden thread, and "wu yue (May)" was the argot of medicinal evodia fruit, etc. In addition, the argots were often used to decipher numerals and quantifiers, for example, "su, qi, zi, qi, man" referring to 1, 2, 3, 4, 5 respectively, and "huo, pu, xiang, feng, lai" referring to 6, 7, 8, 9, 10 respectively, and "qing","zhong","xi" referring to qian, liang and fen respectively. Hence, deciphering of these argots could help to understand and apply these prescriptions correctly.

  5. Classification of Chinese herbs based on the cluster analysis of delayed luminescence.

    Science.gov (United States)

    Pang, Jingxiang; Yang, Meina; Fu, Jialei; Zhao, Xiaolei; van Wijk, Eduard; Wang, Mei; Liu, Yanli; Zhou, Xiaoyan; Fan, Hua; Han, Jinxiang

    2016-03-01

    Traditional Chinese material medica are an important component of the Chinese pharmacopeia. According to the traditional Chinese medicinal concept, Chinese herbal medicines are classified into different categories based on their therapeutic effects, however, the bioactive principles cannot be solely explained by chemical analysis. The aim of this study is to classify different Chinese herbs based on their therapeutic effects by using delayed luminescence (DL). The DL of 56 Chinese herbs was measured using an ultra-sensitive luminescence detection system. The different DL parameters were used to classify Chinese herbs according to a hierarchical cluster analysis. The samples were divided into two groups based on their DL kinetic parameters. Interestingly, the DL classification results were quite consistent with classification according to the Chinese medicinal concepts of 'cold' and 'heat' properties. In this paper, we show for the first time that by using DL technology, it is possible to classify Chinese herbs according to the Chinese medicinal concept and it may even be possible to predict their therapeutic properties.

  6. Biochemia Medica has started using the CrossCheck plagiarism detection software powered by iThenticate.

    Science.gov (United States)

    Supak-Smolcić, Vesna; Simundić, Ana-Maria

    2013-01-01

    In February 2013, Biodhemia Medica has joined CrossRef, which enabled us to implement CrossCheck plagiarism detection service. Therefore, all manuscript submitted to Biodchemia Medica are now first assigned to Research integrity editor (RIE), before sending the manuscript for peer-review. RIE submits the text to CrossCheck analysis and is responsible for reviewing the results of the text similarity analysis. Based on the CrossCheck analysis results, RIE subsequently provides a recommendation to the Editor-in-chief (EIC) on whether the manuscript should be forwarded to peer-review, corrected for suspected parts prior to peer-review or immediately rejected. Final decision on the manuscript is, however, with the EIC. We hope that our new policy and manuscript processing algorithm will help us to further increase the overall quality of our Journal.

  7. Informática Medica: Sistemas de Información y Estándares en Salud

    OpenAIRE

    González Salamea, Carlos G

    2003-01-01

    La informática médica hace relación a la lógica de la atención en salud, aunque la primera imagen que nos viene a la mente es la de un ordenador con sus programas de agenda medica, historia clínica, consulta de bibliografía mediante textos o de guías de práctica clínica, en esta ocasión el interés se centra en el manejo de la información como insumo fundamental en la practica medica. El término informática esta vinculado fuertemente a la tecnología de la computación, pero ante el acelerado gr...

  8. Genome sequence of Ensifer medicae strain WSM1369; an effective microsymbiont of the annual legume Medicago sphaerocarpos.

    Science.gov (United States)

    Terpolilli, Jason; Garau, Giovanni; Hill, Yvette; Tian, Rui; Howieson, John; Bräu, Lambert; Goodwin, Lynne; Han, James; Liolios, Konstantinos; Huntemann, Marcel; Pati, Amrita; Woyke, Tanja; Mavromatis, Konstantinos; Markowitz, Victor; Ivanova, Natalia; Kyrpides, Nikos; Reeve, Wayne

    2013-12-20

    Ensifer medicae WSM1369 is an aerobic, motile, Gram-negative, non-spore-forming rod that can exist as a soil saprophyte or as a legume microsymbiont of Medicago. WSM1369 was isolated in 1993 from a nodule recovered from the roots of Medicago sphaerocarpos growing at San Pietro di Rudas, near Aggius in Sardinia (Italy). WSM1369 is an effective microsymbiont of the annual forage legumes M. polymorpha and M. sphaerocarpos. Here we describe the features of E. medicae WSM1369, together with genome sequence information and its annotation. The 6,402,557 bp standard draft genome is arranged into 307 scaffolds of 307 contigs containing 6,656 protein-coding genes and 79 RNA-only encoding genes. This rhizobial genome is one of 100 sequenced as part of the DOE Joint Genome Institute 2010 Genomic Encyclopedia for Bacteria and Archaea-Root Nodule Bacteria (GEBA-RNB) project.

  9. Volatile and Flavonoid Composition of the Peel of Citrus medica L. var. Corsican Fruit for Quality Assessment of Its Liqueur

    Science.gov (United States)

    Venturini, Nicolas; Barboni, Toussaint; Curk, Franck; Costa, Jean

    2014-01-01

    Summary The volatile and flavonoid compositions of the peel of Citrus medica L. var. Corsican fruits cultivated in Corsica were studied according to the maturity of the citron fruits measured using growing degree-days. Quantitative variation with the stage of development of the fruit was observed using gas chromatography, gas chromatography-mass spectrometry, and liquid chromatography-mass spectrometry/mass spectrometry. Thirty volatile compounds were identified in the peel essential oil. Limonene and γ-terpinene were the major compounds. The volatile compositions of commercial citron liqueurs were also characterized by high amounts of monoterpene hydrocarbons with the same two major components. The main flavonoid components of citron fruits and derived liqueurs were rutin and neohesperidin. This chemical characterization can be used for quality assessment of food products from C. medica var. Corsican. PMID:27904313

  10. Things Chinese.

    Science.gov (United States)

    Law, Yip Wang

    Presented in this booklet are brief descriptions of items and activities that are symbolic of Chinese culture. Some of the items and activities described include a traditional Chinese child's outfit, dolls, sandalwood fans, writing and printing materials and techniques, toys and crafts, a Chinese abacus, and eating utensils. Several recipes for…

  11. Evaluation and comparison of white mineral trioxide aggregate and formocresol medicaments in primary tooth pulpotomy: Clinical and radiographic study

    OpenAIRE

    Cheranjeevi Jayam; Malay Mitra; Jiban Mishra; Bhaswar Bhattacharya; Biswanath Jana

    2014-01-01

    Aim: The primary aim of the following study is to evaluate and secondary aim is to compare clinically and radiographically the success of using white mineral trioxide aggregate (MTA) versus formocresol (FC) medicament for primary tooth pulpotomy. Materials and Methods: A total of 100 teeth were selected for pulpotomy; of which 50 teeth underwent FC pulpotomy and 50 teeth underwent pulpotomy with white MTA. Out of 100 treated teeth, 82 teeth (42 FC and 40 MTA teeth) were available at the end o...

  12. Clinical and radiographic comparison of various medicaments used for pulpotomy in primary molars: A randomized clinical trial

    OpenAIRE

    2016-01-01

    Objective: To evaluate and compare the efficacy of ferric sulfate, glutaraldehyde, and mineral trioxide aggregate (MTA) as pulpotomy medicaments in primary molars. Materials and Methods: This was a perspective randomized clinical trial. A total of 90 molars from 42 children aged 4–8 years were selected for pulpotomy procedure. Teeth were randomly divided into three equal groups of 30 teeth each. Teeth in Group I were intended to be treated with ferric sulfate, Group II were intended to be tre...

  13. Green synthesis of copper nanoparticles by Citrus medica Linn. (Idilimbu) juice and its antimicrobial activity.

    Science.gov (United States)

    Shende, Sudhir; Ingle, Avinash P; Gade, Aniket; Rai, Mahendra

    2015-06-01

    We report an eco-friendly method for the synthesis of copper nanoparticles (CuNPs) using Citron juice (Citrus medica Linn.), which is nontoxic and cheap. The biogenic copper nanoparticles were characterized by UV-Vis spectrophotometer showing a typical resonance (SPR) at about 631 nm which is specific for CuNPs. Nanoparticles tracking analysis by NanoSight-LM20 showed the particles in the range of 10-60 nm with the concentration of 2.18 × 10(8) particles per ml. X-ray diffraction revealed the FCC nature of nanoparticles with an average size of 20 nm. The antimicrobial activity of CuNPs was determined by Kirby-Bauer disk diffusion method against some selected species of bacteria and plant pathogenic fungi. It was reported that the synthesized CuNPs demonstrated a significant inhibitory activity against Escherichia coli followed by Klebsiella pneumoniae, Pseudomonas aeruginosa, Propionibacterium acnes and Salmonella typhi. Among the plant pathogenic fungi tested, Fusarium culmorum was found to be most sensitive followed by F. oxysporum and F. graminearum. The novelty of this work is that for the first time citron juice was used for the synthesis of CuNPs.

  14. Complete genome sequence of the Medicago microsymbiont Ensifer (Sinorhizobium) medicae strain WSM419

    Energy Technology Data Exchange (ETDEWEB)

    Reeve, Wayne [Murdoch University, Perth, Australia; Chain, Patrick S. G. [Lawrence Livermore National Laboratory (LLNL); O' Hara, Graham [Murdoch University, Perth, Australia; Ardley, Julie [Murdoch University, Perth, Australia; Nandesena, Kemanthi [Murdoch University, Perth, Australia; Brau, Lambert [Murdoch University, Perth, Australia; Tiwari, Ravi [Murdoch University, Perth, Australia; Malfatti, Stephanie [Lawrence Livermore National Laboratory (LLNL); Kiss, Hajnalka [Los Alamos National Laboratory (LANL); Lapidus, Alla L. [U.S. Department of Energy, Joint Genome Institute; Copeland, A [U.S. Department of Energy, Joint Genome Institute; Nolan, Matt [U.S. Department of Energy, Joint Genome Institute; Land, Miriam L [ORNL; Hauser, Loren John [ORNL; Chang, Yun-Juan [ORNL; Ivanova, N [U.S. Department of Energy, Joint Genome Institute; Mavromatis, K [U.S. Department of Energy, Joint Genome Institute; Markowitz, Victor [U.S. Department of Energy, Joint Genome Institute; Kyrpides, Nikos C [U.S. Department of Energy, Joint Genome Institute; Gollagher, Margaret [Murdoch University, Perth, Australia; Yates, Ron [Murdoch University, Perth, Australia; Dilworth, Michael [Murdoch University, Perth, Australia; Howieson, John [Murdoch University, Perth, Australia

    2010-01-01

    Ensifer (Sinorhizobium) medicae is an effective nitrogen fixing microsymbiont of a diverse range of annual Medicago (medic) species. Strain WSM419 is an aerobic, motile, non-spore forming, Gram-negative rod isolated from a M. murex root nodule collected in Sardinia, Italy in 1981. WSM419 was manufactured commercially in Australia as an inoculant for annual medics during 1985 to 1993 due to its nitrogen fixation, saprophytic competence and acid tolerance properties. Here we describe the basic features of this organism, together with the complete genome sequence, and annotation. This is the first report of a complete genome sequence for a microsymbiont of the group of annual medic species adapted to acid soils. We reveal that its genome size is 6,817,576 bp encoding 6,518 protein-coding genes and 81 RNA only encoding genes. The genome contains a chromosome of size 3,781,904 bp and 3 plasmids of size 1,570,951 bp, 1,245,408 bp and 219,313 bp. The smallest plasmid is a feature unique to this medic microsymbiont.

  15. A acetamida de pirrolidona como medicação auxiliar no tratamento da paralisia cerebral

    Directory of Open Access Journals (Sweden)

    Francisca Salete Pinheiro Chagas Ribeiro

    1976-06-01

    Full Text Available Vinte crianças, com diagnóstico de paralisia cerebral (PC e sob tratamento clássico, fisioterápico e pedagógico, receberam piracetam (acetamida de pirrolidona como medicação auxiliar. O objetivo foi melhorar os problemas de espasticidade, apredizagem, neurolabilidade, visando a um rendimento melhor do tratamento global da PC. O grupo medicado foi comparado com um grupo controle de 20 crianças que só eram objeto do tratamento habitual. A comparação mostrou resultados favoráveis no grupo medicado. A droga foi administrada na dose de 80 mg/kg/dia durante 10 semanas. Os critérios de avaliação dos resultados foram psicológicos, clínico, fisioterápico e pedagógico. A droga foi administrada em nova forma de apresentação: solução, para uso oral, a 6%.

  16. Phenotypic and genetic diversity in Sinorhizobium meliloti and S. medicae from drought and salt affected regions of Morocco

    Directory of Open Access Journals (Sweden)

    Udupa Sripada M

    2010-01-01

    Full Text Available Abstract Background Sinorhizobium meliloti and S. medicae are symbiotic nitrogen fixing bacteria in root nodules of forage legume alfalfa (Medicago sativa L.. In Morocco, alfalfa is usually grown in marginal soils of arid and semi-arid regions frequently affected by drought, extremes of temperature and soil pH, soil salinity and heavy metals, which affect biological nitrogen fixing ability of rhizobia and productivity of the host. This study examines phenotypic diversity for tolerance to the above stresses and genotypic diversity at Repetitive Extragenic Pallindromic DNA regions of Sinorhizobium nodulating alfalfa, sampled from marginal soils of arid and semi-arid regions of Morocco. Results RsaI digestion of PCR amplified 16S rDNA of the 157 sampled isolates, assigned 136 isolates as S. meliloti and the rest as S. medicae. Further phenotyping of these alfalfa rhizobia for tolerance to the environmental stresses revealed a large degree of variation: 55.41%, 82.16%, 57.96% and 3.18% of the total isolates were tolerant to NaCl (>513 mM, water stress (-1.5 MPa, high temperature (40°C and low pH (3.5, respectively. Sixty-seven isolates of S. meliloti and thirteen isolates of S. medicae that were tolerant to salinity were also tolerant to water stress. Most of the isolates of the two species showed tolerance to heavy metals (Cd, Mn and Zn and antibiotics (chloramphenicol, spectinomycin, streptomycin and tetracycline. The phenotypic clusters observed by the cluster analysis clearly showed adaptations of the S. meliloti and S. medicae strains to the multiple stresses. Genotyping with rep-PCR revealed higher genetic diversity within these phenotypic clusters and classified all the 157 isolates into 148 genotypes. No relationship between genotypic profiles and the phenotypes was observed. The Analysis of Molecular Variance revealed that largest proportion of significant (P Conclusion High degree of phenotypic and genotypic diversity is present in S

  17. Materia prima

    OpenAIRE

    La Croce, Ernesto

    1986-01-01

    La originalidad del esquema aristotélico está dada por la postulación del sustrato, que al asegurar la permanencia del proceso permite resolver las célebres aporías que el cambio y el movimiento habían despertado entre los griegos. Ahora bien, cuando se tra­ta de un cambio accidental (alteración, aumento o translación), el sustrato material se ex­hibe a nuestra percepción con toda evidencia. Porque, siendo accidentales la forma que se abandona y la forma que se acoge, entonces su correlato ma...

  18. Diagramas de energía, fuerza y materia = Diagrams of energy, force and matter

    Directory of Open Access Journals (Sweden)

    Josep Maria Montaner

    2013-10-01

    Full Text Available ResumenEn este ensayo se va a tratar sobre arquitectura a partir de la definición de forma como “estructura esencial e interna, como construcción del espacio y de la materia”. Para ello, podemos establecer, como punto de partida, que el proceso de la arquitectura va de la energía, las fuerzas y la materia hacia la forma. Por tanto, teorizar sobre la forma en arquitectura nos lleva a reflexionar sobre tres fenómenos previos a su configuración: la energía, las fuerzas y la materia. Para seguir estos procesos físicos es útil remitirse al pensamiento postestructuralista de Gilles Deleuze y Félix Guattari, especialmente a su texto Mil Mesetas. Capitalismo y esquizofrenia (1980 y a conceptos como “rizoma” y “agenciamiento” y, sobre todo, utilizar la herramienta interpretativa y creativa del “diagrama”.Palabras claveenergía, fuerza, materia, forma, Deleuze, GuattariAbstractThis essay will deal on architecture from the defi nition of form as "critical and internal structure  as construction of space and matter." For that, we can establish, as a starting point, that the process of architecture goes from energy, forces and matter to form. Thus, theorizing about form in architecture leads us to refl ect on three prior phenomena to its confi guration: energy, forces and matter. To follow these physical processes is useful to refer the poststructuralist thought´s Gilles Deleuze and Felix Guattari, especially his text A Thousand Plateaus. Capitalism and Schizophrenia (1980 and concepts such as "rhizome" and "assemblage" and, above all, to use the creative and interpretative tool of "diagramme".Key wordsenergy, force, matter, form, Deleuze, Guattari

  19. Aprendizaje estratégico en la universidad. Una materia para aprender a aprender

    OpenAIRE

    Gargallo López, Bernardo; Campos Aparicio, Carmen

    2013-01-01

    Diseñamos una asignatura de libre elección de cuatro créditos, denominada “Estrategias de aprendizaje y técnicas de estudio para estudiantes universitarios”. En este trabajo se valoran sus efectos sobre las estrategias de aprendizaje, los enfoques de aprendizaje y el rendimiento académico de estudiantes universitarios. Se usó para ello un diseño preexperimental con pretest y postest, tomándose medidas antes de comenzar la docencia de la materia y después de finalizarla. Los alumnos fueron ent...

  20. Hacia un sistema unitario europeo en materia de ley aplicable a las sucesiones internacionales

    OpenAIRE

    Lafuente Sánchez, Raúl

    2013-01-01

    Una de las consecuencias de la creciente movilidad de los ciudadanos en la Unión Europea es el aumento exponencial de sucesiones que presentan una dimensión internacional. La sucesión de estos nacionales de la Unión se plantea cuanto menos compleja, debido a la disparidad legislativa existente en materia de sucesiones y la inseguridad jurídica que provoca la multiplicidad de regímenes jurídicos en el ámbito del Derecho internacional privado de sucesiones en la Unión Europea. El nuevo Reglamen...

  1. El control de las omisiones del poder público en materia de Derechos fundamentales.

    OpenAIRE

    Gavara de Cara, Juan Carlos

    2007-01-01

    En este trabajo se analizan las consecuencias del control de las omisiones del poder público en materia de derechos fundamentales, tanto en relación con la actividad del poder legislativo como de los poderes ejecutivo y judicial tras la reciente reforma de la Ley Orgánica del Tribunal Constitucional. Particularmente se examinan las posibilidades de articular un control de carácter material de la insuficiencia normativa de la ley a través del principio de defecto de protección de los...

  2. LA MATERIA DE MÚSICA EN EL TRATAMIENTO DE ALUMNOS DE SECUNDARIA CON TDAH

    OpenAIRE

    Violero-López, Ana Pilar

    2013-01-01

    El presente estudio, propone la materia de música en Educación Secundaria como alternativa terapéutica para ayudar a los alumnos con TDAH a afrontar este trastorno. El trastorno por déficit de atención e hiperactividad (TDAH), afecta entorno al 3-7% de la población infantil, en su mayoría varones. A pesar de que este porcentaje se encuentra por debajo de otros trastornos infantiles, los expertos calculan que por cada aula hay un alumno afectado con TDAH. Aunque durante la adolesce...

  3. Reconocimiento de certificaciones y decisiones judiciales en materia de estado civil

    OpenAIRE

    1998-01-01

    Comentario a la Sentencia del Tribunal de Justicia de las Comunidades Europeas, de 2 de Diciembre de 1997 (Asunto C-336/1994), Eftalia Dafeki c. Landesversicherungsanstalt Württemberg. Se analiza la compatibilidad con el Derecho comunitario de la legislación alemana que, en materia de eficacia de certificaciones extranjeras sobre estado civil, no les reconoce presunción de exactitud alguna –cosa que sí hace con las nacionales– y las somete a la libre apreciación de las autoridades alemanas...

  4. Materias primas vs materia gris

    Directory of Open Access Journals (Sweden)

    Fabio Aldemar Gómez Sierra

    2008-10-01

    Full Text Available Los alimentos y los combustibles, en la última década, sobre pasaron el límite de la demanda; la causa no es sólo la evolución demográfica, ni el cambio climático, también es el efecto de las emergentes y poderosas economías asiáticas, especialmente la China, que está aumentando la exigencia energética y consume más y mejores alimentos; 500 millones de ciudadanos chinos están en capacidad de requerirlos y de viajar por el mundo como turistas.

  5. Arbitraje en América Latina. Consideraciones en materia de inversiones

    Directory of Open Access Journals (Sweden)

    Natasha Suñé

    2015-03-01

    Full Text Available Los países de América Latina atravesaron distintas etapas en relación a su postura frente al arbitraje. Fueron, en distintos período de tiempo, precursores, reticentes e innovadores ante este medio alternativo de solución de controversias, y hoy deberían encontrar un posicionamiento común. Quizá como respuesta a las deficiencias de los sistemas multilaterales o frente a un desequilibro entre los intereses de los países desarrollados y en desarrollo, se vislumbra una necesidad de adecuación de los métodos de resolver conflictos a un mecanismo más equitativo y representativo de distintos intereses. Ante esta realidad son los países de la región quienes deben posicionarse y negociar con una única voz. Más aún en relación a las consideraciones particulares en materia de inversiones que debieran emprender en los próximos años. Para analizar la temática del arbitraje en América Latina, dividiremos en etapas históricas los posicionamientos frente a este mecanismos de solución de disputas (precursora, reticente e innovadora para luego analizar el estado actual, los desafíos que enfrenta la región en materia de inversiones y las perspectivas futuras.

  6. Concepto y trascendencia del derecho de aprovechamiento en materia de aguas (Propiedad y Aprovechamiento

    Directory of Open Access Journals (Sweden)

    Enrique Guerra Daneri

    2013-12-01

    Full Text Available La disciplina de las aguas se encuentra estructurada jurídicamente, sólo en base a dos derechos: el de propiedad y el de aprovechamiento. La caracterización que posee el agua como cosa, impide que puedan ejercerse otros derechos sobre ella.El punto de partida para explicar este fenómeno, radica en que el agua responde a dos hechos técnicos que ofician como fuente material o factor de calificación jurídica: el principio de territorialidad y la unidad del ciclo hidrológico. Estos dan motivo a su comportamiento universal y en ellos se asienta su disciplina, más allá de la regulación particular que cada derecho positivo quiera desarrollar, imponiendo una política en la materia.  En síntesis, el agua es un bien cuyas particularidades determinan que en definitiva, el derecho de propiedad sea desplazado en su trascendencia patrimonial por otro derecho que ocupa su lugar en jerarquía e individualidad: el derecho de aprovechamiento. Sin embargo y a pesar de los sólidos fundamentos que lo sustentan, la identidad de este derecho parece todavía opacada por los reflejos de una propiedad, que en materia de aguas, es inoperante.       

  7. Erros de medicação: quem foi? Medication errors: who is responsible?

    Directory of Open Access Journals (Sweden)

    Mário Borges Rosa

    2003-09-01

    Full Text Available Novas tecnologias diagnósticas e terapêuticas são cada vez mais utilizadas, melhorando a qualidade assistencial e aumentando a expectativa de vida; entretanto, a atenção à saúde vem se tornando mais cara e complexa. Os eventos adversos relacionados à assistência, especialmente os erros, são cada vez mais conhecidos, discutidos e julgados em tribunais. Os profissionais de saúde, devido à sua formação, não estão preparados para lidar com os erros, pois estes estão associados à vergonha, ao medo e às punições. A abordagem dos erros no sistema de saúde é, geralmente, feita de forma individualista, considerando os erros como atos inseguros cometidos por pessoas desatentas, desmotivadas e com treinamento deficiente. Quando o erro ocorre, a tendência é escondê-lo, perdendo-se oportunidade importante de aprendizado. Existe outro modo de lidar com erros, a visão sistêmica, que na sua aplicação apresenta bons resultados em setores como aviação, anestesia e sistemas de distribuição de medicamentos por dose unitária. Os sistemas possuem graus variados de segurança e devem levar em conta, na sua construção e funcionamento, as limitações humanas. Em relação ao uso dos medicamentos, uma mudança de paradigma é necessária, pois não basta um medicamento ter qualidade garantida, mas o seu processo de utilização também deve ser seguro. Os erros de medicação, que são por definição evitáveis, são atualmente um sério problema de saúde pública, levando a perdas de vidas e desperdício importante de recursos financeiros. A abordagem sistêmica dos erros de medicação poderá revelar as falhas do processo, sendo possível implementar melhorias, diminuindo, assim, a ocorrência desses eventos.New diagnostic and therapeutic technologies are used with growing frequency, improving the quality of medical assistance and increasing life expectancy. Health care, however, is becoming progressively more expensive and

  8. Effect of intracanal medicaments on push-out bond strength of Smart-Seal system

    Directory of Open Access Journals (Sweden)

    Vibha Hegde

    2015-01-01

    Full Text Available Aim: To evaluate the effects of calcium hydroxide (CH, triple and double antibiotic pastes (DAPs on the bond strength of Smart-Seal obturation, C-points with Endosequence Bio-ceramic (BC sealer to the root canal dentin. Materials and Methods: Sixty-four freshly extracted single-rooted human mandibular premolars were de-coronated and prepared using rotary Pro-taper system with full sequence till F3. The specimens were randomly divided into a control group (without intracanal dressing and 3 experimental groups that received an intracanal dressing with either CH, DAP, or triple antibiotic paste (TAP (n = 16. The intracanal dressing was removed after 3 weeks by rinsing with 10 mL 17% ethylenediaminetetraacetic acid, followed by 10 mL 3% sodium hypochlorite. The root canals were then obturated with C-points and Endosequence BC sealer. A push-out test was used to measure the bond strength between the root canal dentin and the obturating system. The data were analyzed using two-way analysis of variance and Tukey post-hoc test. Results: The push-out bond strength values were significantly affected by the intracanal medicaments (P 0.05. In the middle and apical third, the bond strength of the TAP group was higher than those of the CH and DAP groups (P < 0.05. Conclusions: The DAP and CH did not affect the bond strength of the novel hydrophilic obutrating system. TAP improved the bond strength of Smart-Seal system in the middle and apical thirds.

  9. Alfalfa microsymbionts from different ITS and nodC lineages of Ensifer meliloti and Ensifer medicae symbiovar meliloti establish efficient symbiosis with alfalfa in Spanish acid soils.

    Science.gov (United States)

    Ramírez-Bahena, Martha-Helena; Vargas, Margarita; Martín, María; Tejedor, Carmen; Velázquez, Encarna; Peix, Álvaro

    2015-06-01

    Alfalfa (Medicago sativa L.) is an important crop worldwide whose cropping in acid soils is hampered by the poor nodulation and yield commonly attributed to the sensitivity of its endosymbionts to acid pH. In this work, we isolated several acid-tolerant strains from alfalfa nodules in three acid soils in northwestern Spain. After grouping by RAPD fingerprinting, most strains were identified as Ensifer meliloti and only two strains as Ensifer medicae according to their 16S-23S intergenic spacer (ITS) sequences that allowed the differentiation of two groups within each one of these species. The two ITS groups of E. meliloti and the ITS group I of E. medicae have been previously found in Medicago nodules; however, the group II of E. medicae has been only found to date in Prosopis alba nodules. The analysis of the nodC gene showed that all strains isolated in this study belong to the symbiovar meliloti, grouping with the type strains of E. meliloti or E. medicae, but some harboured nodC gene alleles different from those found to date in alfalfa nodules. The strains of E. medicae belong to the symbiovar meliloti which should be also recognised in this species, although they harboured a nodC allele phylogenetically divergent to those from E. meliloti strains. Microcosm experiments showed that inoculation of alfalfa with selected acid-tolerant strains significantly increased yields in acid soils representing a suitable agricultural practice for alfalfa cropping in these soils.

  10. Application of Translational Medicine Concept in Chinese Materia Medica:Effect and Mechanism of Mahuang and Wuweizi on Pulmonary Fibrosis

    Institute of Scientific and Technical Information of China (English)

    QIN Hai-zhi; DONG Wei-tao

    2015-01-01

    Objective:To explore the effect and mechanism of Mahuang (Herba Ephedra) and Wuweizi (Schisandra Chinesis) on pulmonary ifbrosis based on translation medicine theory. Methods: Totally 90 Wistar rats were divided into 6 groups. Pulmonary ifbrosis models of rats were established by drip of bleomycin A5 through trachea while sham-operation group was infused with equivalent normal saline instead of bleomycin A5 into trachea. Sham-operation group and negative control group were performed with normal saline gavage while positive control group with subcutaneous injection of hydrocortisone, Mahuang group and Wuweizi group with gavage of Mahuang and Wuweizi concentrated decoction, respectively, whereas combined group was treated with gavage of Mahuang concentrated decoction during the ifrst 7 days and with Wuweizi concentrated decoction in the ensuing 21 days. On the 7th day and 28th day, pulmonary alveolitis and fibrosis in different groups were observed and the expression levels of serum vascular endothelial growth factor (VEGF), angiopoietin-2 (Ang-2), thrombospondin-1 (TSP-1), monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein-1α (MIP-1α) were detected and compared. Results: All models of groups were successfully established. Compared with negative control group, the levels of VEGF, Ang-2, MCP-1 and MIP-1α decreased in different degrees but TSP-1 increased in other groups after medication for 7 days and 28 days. Conclusion: Mahuang and Wuweizi have intervention effects on pulmonary fibrosis, the mechanism of which might be related to the inhibition of excessive angiogenesis through inhibiting the expression of MCP-1 and MIP-1α, lowering the level of proangiogenic factors (Ang-2 and BEGF), and enhancing the level of angiogenesis inhibiting factor (TSP-1).

  11. Mourning for renowned pharmacologist Professor Geng-Tao Liu

    Institute of Scientific and Technical Information of China (English)

    Lian-Sheng Ma

    2010-01-01

    At 22:08 h on February 27, 2010, Professor Geng-Tao Liu, a renowned pharmacologist affiliated with the Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing, an academician of the Chinese Academy of Engineering, a doctoral tutor, and a member of World Journal of Gastroenterology (WJG) Editorial Board, passed away at Peking Union Medical College Hospital, at the age of 77 years (Figure 1).

  12. PISA: n??meros, estandarizaci??n de la conducta y la alquimia de las materias escolares

    OpenAIRE

    Popkewitz, Thomas S.

    2013-01-01

    Este art??culo examina la red de pr??cticas que confieren inteligibilidad a la organizaci??n del conocimiento de las materias escolares que hace PISA. El programa PISA es tratado como un acontecimiento hist??rico. Su estudio consiste en hacer visible los principios que ordenan y clasifican los objetos ???vistos??? y que act??an sobre el ???conocimiento pr??ctico??? de las materias escolares. La pol??tica de PISA, a mi juicio, son los principios que rigen lo que los chicos deber??a...

  13. Nuevos datos sobre el uso de materia colorante durante el Neolítico antiguo en las comarcas centrales valencianas

    Directory of Open Access Journals (Sweden)

    Pablo García Borja

    2006-01-01

    Full Text Available La caracterización mineralógica de materias colorantes procedentes de los yacimientos valencianos de la Cova de l'Or, la Cova de la Sarna y la Cova Fosca de la Vall d'Ebo demuestra el uso de dos tipos de materia colorante durante el Neolítico Antiguo: Hematites y Cinabrio. Las características y distribución geográfica de cada una de ellas nos remiten a dos estrategias distintas de obtención y. probablemente. de utilización de las mismas.

  14. Parámetros de Transferencia de Materia en el Secado de Frutas Mass Transfer Parameters in Fruit Drying

    OpenAIRE

    Ferreira, Sebastião R.; Antônio R. S Costa

    2009-01-01

    Se desarrolló un modelo analítico para obtención de parámetros de transferencia de materia en el secado de frutas. El modelo considera la disminución del radio de las frutas durante el proceso de secado. Con el modelo matemático se predice simultánemente el coeficiente externo de transferencia de materia k m y la difusividad de agua en los frutos D AB. Para probar el modelo se obtuvo en forma expermental datos de masa de agua M A en la fruta versus el tiempo de secado t, además del radio inic...

  15. 中医拔火罐疗法与临床护理观察%Observation of the traditional Chinese medicine cupping therapy and clinical nursing

    Institute of Scientific and Technical Information of China (English)

    周秀玲; 梁凤珍

    2013-01-01

    中医拔火罐疗法,是祖国医学遗产之一,拔罐法又名“火罐气”“吸筒疗法”,古称“角法”。是以杯罐作工具,借热力排去其中的空气产生负压,将罐吸着于皮肤,造成瘀血现象的一种疗法。在马王堆汉墓出土的帛书《五十二病方》中就有记载,历代中医文献中论述颇多。如《本草纲目拾遗》中说:“罐得火气合于肉,即牢不可脱,……肉上起红晕,罐中有水气出,风寒尽出”这是对拔罐法应用的记载。拔火罐是一种中医外治疗法,这种疗法可以逐寒祛湿、疏通经络、祛除瘀滞、行气活血、消肿止痛、拔毒泻热,具有调整人体的阴阳平衡、解除疲劳、增强体质的功能,从而达到扶正祛邪、治愈疾病的目的。许多疾病都可以采用拔火罐疗法进行治疗。因此,在临床中得到广泛应用。%Chinese medicine cupping therapy, is one of the legacy of Chinese medicine, cupping also known as "gas" and "cupping", cal ed "angle method". Is the jar as a tool, by thermal venting air negative pressure tank, the adsorption on the skin, a phenomenon caused by blood stasis therapy. In the Mawangdui of silk manuscripts unearthed "fifty-two party" were recorded in ancient literature of TCM, there are a lot of discussions. Such as "supplement to compendium of Materia Medica" said: "the tank was anger in meat, which is inseparable from,. . . Red meat, tank with water, cold as wel as "the cupping method records. Cupping is a kind of external therapy of traditional Chinese medicine, this therapy can by cold and dampness, dredge main and col ateral channels, removing blood stasis, promoting circulation of Qi and blood, acetanilide detumescence, Sida Xiere, can adjust the balance of yin and Yang, body lifting fatigue, enhance physical function, so as to achieve the purpose of curing diseases, pathogen. Many diseases can be used cupping therapy. Therefore, widely used in

  16. Effect of Calcium Hydroxide Based Intracanal Medicaments on the Apical Sealing Ability of Resin Based Sealer and Guttapercha Obturated Root Canals

    Science.gov (United States)

    Sumanthini, MV; Shenoy, Vanitha U; Bodhwani, Mohit A

    2017-01-01

    Introduction Calcium Hydroxide (CH) is one of the most commonly used intracanal medicaments which can be used with various vehicles. Aim The aim of this in vitro study was to evaluate the effect of three CH based intracanal medicaments on the apical sealing ability of AH Plus – guttapercha obturation. Materials and Methods Crowns of 100 extracted single rooted human teeth were sectioned at the Cemento-Enamel Junction (CEJ) to a standardized length. The root canals were instrumented upto ISO size 40 using step back technique and the specimens were randomly divided into two control and four experimental groups. The control groups were not medicated. Specimens in positive control group (Group I) were obturated with guttapercha without placing sealer and in negative control group (Group II) were obturated with guttapercha and AH Plus sealer. Among the experimental groups, specimens of Group III were not medicated while groups IV, V and VI were medicated with CH-saline, CH-2% Chlorhexidine (CHX) and Vitapex respectively for a period of 14 days. The medicaments were removed from the specimens and the teeth were obturated with AH Plus sealer and guttapercha using lateral compaction technique. The specimens were immersed in India ink dye, demineralized and diphanized. The extent of dye penetration was assessed using a 10X stereomicroscope. Data obtained was statistically analyzed by one-way ANOVA (p<0.05) followed by Post-hoc Tukey test. Results Amongst the three CH medicaments, CH-2% CHX when used as an intracanal medicament showed a significantly higher microleakage as compared to the other groups with p<0.001. The microleakage values between the remaining groups were not statistically significant. Conclusion Under the conditions of this study it was concluded that all groups with or without intracanal medicament showed apical leakage. The vehicle used to carry CH may significantly influence the apical sealing ability of guttapercha – AH Plus obturated canals. PMID

  17. Delimitación jurisprudencial del principio constitucional de unidad de materia legislativa

    Directory of Open Access Journals (Sweden)

    Manuel Alberto Restrepo-Medina

    2010-03-01

    Full Text Available El principio de unidad de materia legislativa es uno de los ejes fundamentales del proceso de formación de la ley, y su observancia constituye un parámetro para la determinación jurisdiccional de la validez jurídica, en la medida en que, de una parte, se verifique la existencia de coherencia y armonía en el producto normativo por la conexidad entre sus partes, y de otra parte, a partir del cumplimiento de ese mínimo, se respete la libertad de configuración del Congreso en razón de la legitimidad democrática de la cual está investido para ejercer su función legislativa.

  18. Aprendizaje cooperativo en la materia dirección de producción y operaciones

    Directory of Open Access Journals (Sweden)

    Eloísa Díaz-Garrido

    2013-11-01

    Full Text Available En el presente estudio se analizan los resultados de implantar el aprendizaje cooperativo en un grupo de estudiantes que cursan la asignatura Dirección de Producción, en el segundo curso del Grado de Administración y Dirección de Empresas de la Universidad Rey Juan Carlos (Madrid-España. Si bien la asignatura ya está adaptada al Espacio Europeo de Educación Superior (EEES y se desarrolla aplicando metodologías activas orientadas al proceso de enseñanza-aprendizaje, se ha optado por aplicar un método de enseñanza diferente. La experiencia desarrollada ha permitido obtener interesantes resultados, los alumnos perciben haber mejorado sus capacidades de comunicación, sus competencias intelectuales asociadas a la materia y profesionales asociadas con el trabajo en equipo.

  19. La ejecución de las resoluciones administrativas en materia tributaria

    OpenAIRE

    Martínez Giner, Luis Alfonso

    2008-01-01

    El presente trabajo aborda las cuestiones más controvertidas de la ejecución de las resoluciones administrativas en materia tributaria. Tratándose de uno de los asuntos que más relevancia están adquiriendo en los últimos tiempos en el ámbito tributario, lo cierto es que su régimen jurídico plantea muchas dudas interpretativas y en ocasiones lagunas de difícil resolución. El autor tras una reflexión sobre el alcance y sentido jurídico de la ejecución de resoluciones administrativas analiza crí...

  20. Comparative Study between the "Lista de Encabezamientos de Materia" by Gloria Escamilla and the "Library of Congress Subject Heading" List.

    Science.gov (United States)

    Alvarez, Fernando

    This study shows to what extent Gloria Escamilla's "Lista de Encabezamientos de Materia," the only published Mexican subject heading list, is equivalent to the Library of Congress subject headings (LCSH). A LCSH heading sample is obtained from OCLC's Online Union Catalog. Using the EPIC search from OCLC, 1947 bibliographic records were…

  1. Clinical and radiographical evaluation of mineral trioxide aggregate, biodentine and propolis as pulpotomy medicaments in primary teeth

    Science.gov (United States)

    Rakesh, Kumar; Richa, Khanna

    2015-01-01

    Objectives The purpose of this study was to evaluate the efficacy of mineral trioxide aggregate (MTA), Biodentine and Propolis as pulpotomy medicaments in primary dentition, both clinically and radiographically. Materials and Methods A total of 75 healthy 3 to 10 yr old children each having at least one carious primary molar tooth were selected. Random assignment of the pulpotomy medicaments was done as follows: Group I, MTA; Group II, Biodentine; Group III, Propolis. All the pulpotomized teeth were evaluated at 3, 6, and 9 mon clinically and radiographically, based on the scoring criteria system. Results The clinical success rates were found to be similar among the three groups at 3 and 6 mon where as a significant decrease in success rate was observed in Group III (84%) compared to both Group I (100%) and Group II (100%) at 9 mon. Radiographic success rates over a period of 9 mon in Groups I, II, and III were 92, 80, and 72%, respectively. Conclusions Teeth treated with MTA and Biodentine showed more favorable clinical and radiographic success as compared to Propolis at 9 mon follow-up. PMID:26587413

  2. Genome sequence of Ensifer medicae Di28; an effective N2-fixing microsymbiont of Medicago murex and M. polymorpha.

    Science.gov (United States)

    Garau, Giovanni; Terpolilli, Jason; Hill, Yvette; Tian, Rui; Howieson, John; Bräu, Lambert; Goodwin, Lynne; Han, James; Reddy, Tbk; Huntemann, Marcel; Pati, Amrita; Woyke, Tanja; Mavromatis, Konstantinos; Markowitz, Victor; Ivanova, Natalia; Kyrpides, Nikos; Reeve, Wayne

    2014-01-01

    Ensifer medicae Di28 is an aerobic, motile, Gram-negative, non-spore-forming rod that can exist as a soil saprophyte or as a legume microsymbiont of Medicago spp. Di28 was isolated in 1998 from a nodule recovered from the roots of M. polymorpha growing in the south east of Sardinia (Italy). Di28 is an effective microsymbiont of the annual forage legumes M. polymorpha and M. murex and is capable of establishing a partially effective symbiotic association with the perennial M. sativa. Here we describe the features of E. medicae Di28, together with genome sequence information and its annotation. The 6,553,624 bp standard draft genome is arranged into 104 scaffolds of 104 contigs containing 6,394 protein-coding genes and 75 RNA-only encoding genes. This rhizobial genome is one of 100 sequenced as part of the DOE Joint Genome Institute 2010 Genomic Encyclopedia for Bacteria and Archaea-Root Nodule Bacteria (GEBA-RNB) project.

  3. Genome sequence of Ensifer medicae strain WSM1115; an acid-tolerant Medicago-nodulating microsymbiont from Samothraki, Greece.

    Science.gov (United States)

    Reeve, Wayne; Ballard, Ross; Howieson, John; Drew, Elizabeth; Tian, Rui; Bräu, Lambert; Munk, Christine; Davenport, Karen; Chain, Patrick; Goodwin, Lynne; Pagani, Ioanna; Huntemann, Marcel; Mavrommatis, Konstantinos; Pati, Amrita; Markowitz, Victor; Ivanova, Natalia; Woyke, Tanja; Kyrpides, Nikos

    2014-06-15

    Ensifer medicae strain WSM1115 forms effective nitrogen fixing symbioses with a range of annual Medicago species and is used in commercial inoculants in Australia. WSM1115 is an aerobic, motile, Gram-negative, non-spore-forming rod. It was isolated from a nodule recovered from the root of burr medic (Medicago polymorpha) collected on the Greek Island of Samothraki. WSM1115 has a broad host range for nodulation and N2 fixation capacity within the genus Medicago, although this does not extend to all medic species. WSM1115 is considered saprophytically competent in moderately acid soils (pH(CaCl2) 5.0), but it has failed to persist at field sites where soil salinity exceeded 10 ECe (dS/m). Here we describe the features of E. medicae strain WSM1115, together with genome sequence information and its annotation. The 6,861,065 bp high-quality-draft genome is arranged into 7 scaffolds of 28 contigs, contains 6,789 protein-coding genes and 83 RNA-only encoding genes, and is one of 100 rhizobial genomes sequenced as part of the DOE Joint Genome Institute 2010 Genomic Encyclopedia for Bacteria and Archaea-Root Nodule Bacteria (GEBA-RNB) project.

  4. Avances en materia de regulación mercantil y civil del comercio electrónico en México y los aspectos fiscales del establecimiento permanente

    OpenAIRE

    V. Ma. Antonieta Martin Granados

    2002-01-01

    A pesar de que en México se han realizado adiciones a la legislación en materia civil y mercantil relacionadas con el uso de medios electrónicos como instrumentos para realizar actos jurídicos, éstas resultan insuficientes, pues nada se ha hecho en materia procesal, penal y laboral, entre otras. En este trabajo se presentan, en materia fiscal, algunas consideraciones acerca del concepto de establecimiento permanente tanto en la legislación mexicana como en el Convenio Modelo (CM) de la Organi...

  5. 明晰报告中医药随机对照试验中中药的毒副作用%Transparently reporting adverse effects of traditional Chinese medicine interventions in randomized control1ed trials

    Institute of Scientific and Technical Information of China (English)

    郑颂华; 卞兆祥; 李幼平; David Moher; 吴泰相; Simon Dagenais; 李静; 李廷谦

    2008-01-01

    中药虽取诸天然,但亦可含对人体有害的物质,因此,近年来中药的毒副作用越来越受到关注.中药毒副作用可以分为不可预期类、使用不当类、中药"污染"类、品种混乱类和中西药物相互作用类等.使用不"-3类包括处方不遵从中医药理论、过量使用、炮制及制剂方法不当和配伍不当等;中药"污染"类包括重金属、农药残留及中药产品被化学药物成分"污染".中药的毒副作用,必须明晰报告.过高或过低估计中药的毒副作用,都会误导临床医生及患者.我们建议在中医药随机对照试验报告规范中,报告副作用时,应包括以下方面:研究药物毒副作用的背景资料、针对副作用的特异性结局评估指标;毒副作用的详细内容及其诠释.%Although all Chinese materia medica (CMM) come from nature,CMM interventions have both therapeutic effects and adverse effects (AEs).Normally,AEs in randomized controlled trial (RCT) with traditional Chinese medicine (TCM) could be divided into five types as follows:1)AEs under proper TCM principles and guidelines,such as the toxicity (acute and chronic) and allergy;2) AEs due to improper usage without following TCM principles,involving Without following the TCM therapeutic principles.over-dosage.improper processing and preparation methods,improper formula strategy,etc;3)AEs due to contamination ln CMM,such as heavy metal and pesticides contaminations in Chinese herbal medicine jnterventions,and intentional or unintentional contamination With drug(s);4)AEs due to replacement of CMMs;5)AEs due to drug-herb interaction.AEs of TCM should be treated properly.Overestimation or underestimation about AEs of TCM intervention Will bring a wrong message to patients and health care providers.In order to give readers a more comprehensive Understanding about the safety issue of Study intervention,Consolidated Standards of Reporting Trials (CONSORT) for TCM should involve the backg round

  6. An automated method for the determination of deoxyribonuclease activity as exemplified by fractionation of the components of the medicament Varidase.

    Science.gov (United States)

    Locke, I C; Ramsey, M P; Hill, S S; Carpenter, B G

    1993-01-01

    The activity of most deoxyribonuclease enzymes can be monitored by measuring the change in absorbance at 260 nm which accompanies the breakdown of the double-stranded structure of native DNA. An automated method for determining deoxyribonuclease activity, based on such an absorbance change, which can overcome problems of inhibition arising from the presence of inorganic cations, is described. Variations in inorganic cation concentration is a particular problem when measuring the activity of chromatographic fractions eluted via a salt gradient. A comparison is made between the automated and a manual method for the assay of deoxyribonuclease active constituents, of the medicament 'Varidase', eluted from a Cellex-D (Bio-Rad Laboratories Ltd) anionic exchange resin using a 0.05-1.0 M sodium chloride gradient.

  7. Twenty years of society of medical informatics of b&h and the journal acta informatica medica.

    Science.gov (United States)

    Masic, Izet

    2012-03-01

    In 2012, Health/Medical informatics profession celebrates five jubilees in Bosnia and Herzegovina: a) Thirty five years from the introduction of the first automatic manipulation of data; b) Twenty five years from establishing Society for Medical Informatics BiH; c) Twenty years from establishing scientific and professional journal of the Society for Medical Informatics of Bosnia and Herzegovina "Acta Informatica Medica"; d) Twenty years from establishing first Cathdra for Medical Informatics on biomedical faculties in Bosnia and Herzegovina and e) Ten years from the introduction of "Distance learning" in medical curriculum. All of the five mentioned activities in the area of Medical informatics had special importance and gave appropriate contribution in the development of Health/Medical informatics in Bosnia And Herzegovina.

  8. LAS RELACIONES ENTRE LOS TRIBUNALES INTERNACIONALES Y LOS TRIBUNALES NACIONALES EN MATERIA DE DERECHOS HUMANOS: EXPERIENCIAS EN LATINOAMÉRICA

    Directory of Open Access Journals (Sweden)

    Néstor P. Sagüés

    2003-01-01

    Full Text Available El autor analiza la relación entre los tribunales nacionales e internacionales o supranacionales con competencia jurisdiccional vinculante en materia de derechos humanos, considerando la existencia de tres posiciones en la materia: la posición conflictual de la declaración de inejecutabilidad, la posición del seguimiento nacional y la del margen de apreciación.The author analyzes the relationship between national and international or supranational courts with binding jurisdiction over matters of human rights, reviewing three positions in this subject: the conflict perspective of declaration of non-executability, the position of national follow-up, and the doctrine of margin of appreciation.

  9. El uso de las redes 2.0 como herramienta de conquista del interés por la materia

    OpenAIRE

    Fernández-Coca, Antonio

    2016-01-01

    Presentamos el caso práctico llevado a cabo con la materia que enseña a dibujar a mano alzada a alumnos que vienen con un dominio nulo o prácticamente nulo del dibujo. La asignatura “Expresión Gráfica en Edificación” es una materia troncal en los estudios de Grado en Ingeniería en Edificación. En ella los alumnos aprenden a dibujar planos arquitectónicos empleando solamente su propia mano, lápiz y papel. Los alumnos llegan sin saber dibujar, sin entender que dibujar es un lenguaje más con var...

  10. Proposta per a la governança de risc de la falsificació de medicaments amb una eina de diagnosi basada en lògica difusa

    OpenAIRE

    Bargalló, Manel,

    2016-01-01

    La falsificació de medicaments és un problema inherent a la mateixa existència dels medicaments. Existeixen estudis de l'OMS que indiquen que en alguns països en vies de desenvolupament, entre el deu i el trenta per cent de les medicines que es venen poden ser falses, mentre que no arriba a l'u per cent en els països occidentals. Però darrerament s'ha detectat un augment significatiu d'incidents de falsificació de medicaments en els països desenvolupats, la qual indica que el model clàssic re...

  11. Un modelo general de eyección de materia estelar

    Science.gov (United States)

    Rotstein, N. O.

    Posiblemente, la más directa y dramática evidencia de la pérdida de masa por parte de diferentes objetos astrofísicos la constituye el fenómeno de eyección persistente de materia. En el caso particular de las estrellas, las características y los mecanismos que impulsan a sus atmósferas externas hacia el medio interestelar varían a lo largo del diagrama evolutivo. En parte por este motivo, en parte por las dificultades matemáticas involucradas, es muy difícil elaborar un modelo que pueda dar cuenta de los diferentes mecanismos que originan e impulsan el viento estelar. Cabe entonces preguntarse si es posible desarrollar un único modelo en el que estos mecanismos puedan ser considerados (y variados) como parámetros externos que responden a las características de cada región de la secuencia evolutiva. La respuesta es que, en función de la geometría del campo electromagnético involucrado, todo depende de la simetría del problema. En este trabajo se presenta el análisis detallado de una de tales simetrías, discutiendo en particular los resultados obtenidos a la luz de las observaciones disponibles.

  12. Enjuiciamiento y crítica vigente en materia del ordenamiento de alimentos

    Directory of Open Access Journals (Sweden)

    Teresa Cornejo Fava

    1972-12-01

    Full Text Available En la primera parte de este Capitulo, hemos sistematizado de un modo diferente las normas relativas al derecho alimentario, que en el ordenamiento nacional se hallan diseminadas en diversos cuerpos de leyes,en el intento de lograr mayor coherencia en el conjunto.En este segundo sub-capítulo, haremos un enjuiciamientode aquellas normas, con el objeto de poner en relieve algunas de sus características y eventualmente de sus vacíos y deficiencias. Antes de iniciar esta labor, dos advertencias nos parecen oportunas: a Lade que, dada la amplitud de la materia, habremos de limitarnos a tres áreas de crítica, a saber, la de la implementación de las disposiciones constitucionales,la de las contradicciones reales o aparentes que presenta el ordenamiento vigente, y la de las deficiencias que nos parece advertir en un número de las disposiciones legales más importantes; y b La de que, de momento, no cuestionamos el sistema dentro del cual se institucionaliza actualmente en el Perú la relación alimentaria, cuestión ésta de mucha trascendencia,acerca de la cual diremos algo más adelante.

  13. Historia and materia: the philosophical implications of Francis Bacon's natural history.

    Science.gov (United States)

    Giglioni, Guido

    2012-01-01

    This article examines the philosophical implications underlying Bacon's views on historical knowledge, paying special attention to that variety of historical knowledge described by Bacon as "natural." More specifically, this article explores the interplay of history (historia) and fable (fabula). In the sphere of thought, fabula is the equivalent to materia in nature. Both are described by Bacon as being "versatile" and "pliant." In Bacon's system of knowledge, philosophy, as the domain of reason, starts from historiae and fabulae, once memory and the imagination have fulfilled their cognitive tasks. This means that, for Bacon, there is no such thing as a pure use of reason. He advocates a kind of reason that, precisely because it is involved with matter's inner motions (its "appetites," in Bacon's characteristic language), is constitutively 'impure'. The article shows how the terms historia and fabula cover key semantic areas in defining Bacon's philosophy: historia may mean "history" as well as "story,"fabula "myth" as well "story". In both cases, we can see significant oscillations from a stronger meaning (close to those of matter and nature) to a weaker one (connected to wit and imagination), as if the power of nature decreases moving from histories and myths to stories. On the other hand, there are cases in which Bacon seems to stick to a diachronic view of the meaning of fables and histories, such that the transition from myths to history, especially natural history, is described as a collective effort towards reality and enlightenment.

  14. La materia dei sogni Sbirciatina su un mondo di cose soffici (lettore compreso)

    CERN Document Server

    Piazza, Roberto

    2010-01-01

    Dall’aria che respiriamo ai cibi di cui ci nutriamo, dai vestiti che indossiamo ai detersivi con cui li laviamo, dai colori con cui dipingiamo agli schermi su cui li guardiamo, la nostra realtà quotidiana brulica di cose troppo piccole per essere viste, ma pur sempre enormi rispetto ai mattoni di cui è fatto il mondo, gli atomi e le molecole. Oltre ad essere alla radice di molte tecnologie di oggi e di domani, questi piccoli personaggi, ingredienti primari di quelli che gli scienziati chiamano "materiali soffici", "sistemi sovramolecolari", o " fluidi complessi", ci permettono anche di esplorare i segreti con cui la materia si organizza spontaneamente, perché anche la Vita altro non è se non l’apoteosi di questa incredibile "Terra di Mezzo", a metà strada tra le molecole e l’Uomo. Sfruttando l’esperienza scientifica accumulata dall’autore nel corso di molti anni, questo libro si propone di guidare il lettore attraverso un lungo, ma non troppo faticoso viaggio nel mondo delle nanoparticelle, dei...

  15. Una perspectiva internacional sobre la formación en materia de seguridad y salud en el trabajo

    Directory of Open Access Journals (Sweden)

    Félix Martín Daza

    Full Text Available El presente artículo tiene el propósito de explorar algunos de los retos más importantes de la formación en la seguridad y salud en el trabajo de los diferentes grupos interesados, así como para presentar los lineamientos de la Organización Internacional del Trabajo en esta materia.

  16. La reforma de las humanidades y la enseñanza de las materias filosóficas en secundaria

    Directory of Open Access Journals (Sweden)

    José María VINUESA ANGULO

    2013-11-01

    Full Text Available Este artículo trata de valorar el probable significado y consecuencias para las materias filosóficas de la reforma de las humanidades en curso dentro de la educación secundaria. El análisis parte de la premisa de que un incremento del horario destinado a cualquier materia (también, por supuesto, a las filosóficas sólo pervivirá si se hace patente que los contenidos programados tienen capacidad formativa y cierto interés para los alumnos. En otro caso, más allá del inicial ordenancismo curricular, cualquier materia (también las filosóficas corre el riesgo de ser completamente erradicada de los Planes de estudio con posterioridad. Se trata de una reflexión a medio plazo, que no trata de discutir lo obvio: las ventajas gremiales a corto plazo que, para el colectivo de profesores de Filosofía, representa el incremento de las horas lectivas que se les adjudican en la reforma. Como elementos auxiliares para esa reflexión, el artículo pasa revista a tres reformas paradigmáticas de las humanidades en la enseñanza secundaria española, intenta dilucidar sus auténticos motivos y procura poner de manifiesto sus consecuencias. Una vez analizadas las reformas de 1845, ?866 y 1938, no es nada optimista la conclusión general respecto a las reformas históricas de las humanidades ni tampoco se alientan grandes expectativas con referencia a lo que la enseñanza de las materias filosóficas puede esperar de su revisión en el contexto de la reforma de las humanidades.

  17. Cosa Juzgada Constitucional Sui Generis y su Efecto en las Sentencias del Tribunal Constitucional en materia de Inaplicabilidad e Inconstitucionalidad

    Directory of Open Access Journals (Sweden)

    Emilio Alfonso Garrote Campillay

    2012-01-01

    Full Text Available En el presente trabajo se abordara la cosa juzgada constitucional y su efecto en las sentencias del Tribunal Constitucional, en materia de inaplicabilidad e inconstitucionalidad. Proponemos una cosa juzgada constitucional sui generis o cosa decidida, en atención a las particularidades que presenta esta institución en el ámbito del Derecho Constitucional, por ende no nos ceñiremos al concepto tradicional del Derecho Procesal Civil.

  18. NCG56/31: Reglamento de R??gimen Interno del Departamento de Electromagnetismo y F??sica de la Materia

    OpenAIRE

    Universidad de Granada

    2012-01-01

    Reglamento de R??gimen Interno del Departamento de Electromagnetismo y F??sica de la Materia. Aprobado en sesi??n extraordinaria del Consejo de Gobierno de la Universidad de Granada celebrada el 20 de febrero de 2012.

  19. PISA: números, estandarización de la conducta y la alquimia de las materias escolares

    Directory of Open Access Journals (Sweden)

    Thomas S. Popkewitz

    2013-01-01

    Full Text Available Este artículo examina la red de prácticas que confieren inteligibilidad a la organización del conocimiento de las materias escolares que hace PISA. El programa PISA es tratado como un acontecimiento histórico. Su estudio consiste en hacer visible los principios que ordenan y clasifican los objetos “vistos” y que actúan sobre el “conocimiento práctico” de las materias escolares. La política de PISA, a mi juicio, son los principios que rigen lo que los chicos deberían conocer, cómo ese conocimiento se hace posible, y el estudio de la inclusión y exclusión incorporadas en estas prácticas. La primera parte analiza históricamente la transformación de los números en “hechos”, una presunción que posibilita las comparaciones de PISA. En la segunda parte, dirige la atención a los principios de las materias escolares que ordenan y clasifican los “hechos” de las mediciones de PISA.

  20. Chinese Dream

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    The general managers of South Korean auto giants Hyundai and Kia have high hopes for the growing Chinese auto market. Both companies went through a painstaking period as the financial crisis first roared across the globe. Jin Shan-fa, General Manager of Hyundai Motor Group

  1. Soluciones concluidas en el MERCOSUR en materia de jurisdicción internacional: Análisis de los protocolos de Buenos Aires sobre jurisdicción internacional en materia contractual y de San Luis en materia de resp. civil emergente de accidentes de tránsito

    Directory of Open Access Journals (Sweden)

    Eduardo Tellechea Bergman

    2015-10-01

    Full Text Available Contenido: Precisiones.  La jurisdicción en las relaciones privadas internacionales en el MERCOSUR. Necesidad de una regulación común a todos los estados parte. Protocolo de Buenos Aires sobre jurisdicción internacional en materia contractual. Protocolo de San Luis sobre responsabilidad civil emergente de accidentes de tránsito

  2. First-order Derivative Spectrophotometry for the Determination of Vitamin C in Medicament

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    A novel method for the determination of vitamin C(Vc) is proposed in this article. After the reaction with Folin-Ciocalteau reagent at ambient temperature, Vc solution was scanned at 750-1100 nm, and its first-order derivative spectrum were obtained from the original spectrum. The values of derivative selected at 995 nm were used for determination. It was proved that Vc could quickly react with Folin-Ciocalteau reagent within 5 min and the product was quite stable for a long time. The conditions required for this method is not very complicated, its precision and accuracy are similar to those of the iodometric titration described in Chinese Pharmacopoeia, and the limit of detection is 0.312μg/mL. The determination of the results of vitamin C tablet, pill, and injection demonstrates that this method has wide pharmaceutical applications.

  3. Chinese Geography through Chinese Cuisine

    Science.gov (United States)

    Lipman, Jonathan

    2010-01-01

    China has the world's largest population, now over 1.3 billion, but its land area (much of it high mountains or desert) is about the same as that of the United States, which has less than one-fourth as many people. So Chinese farmers have learned to use every inch of their fertile land intensively. Pressure on the land has required extremely…

  4. REMOCION DE LA MATERIA ORGANICA Y TOXICIDAD EN AGUAS RESIDUALES HOSPITALARIAS APLICANDO OZONO

    Directory of Open Access Journals (Sweden)

    DAYANA GRISALES PENAGOS

    2012-01-01

    Full Text Available Las aguas residuales hospitalarias se consideran como una de las principales fuentes de contaminantes emergentes, resultado de las diferentes actividades que allí se realizan y la excreción de las sustancias por los pacientes. Estudios han demostrado que estos componentes no son fácilmente removidos por medio de procesos de tratamiento convencionales como las plantas de tratamiento que emplean procesos biológicos. En este sentido el propósito de este trabajo consistió en evaluar la degradación de la materia orgánica presente en aguas hospitalarias reales aplicando ozono en diferentes condiciones de pH (3,0, 6,7, 10. Para esto se analizaron los valores de la UV254, la relación de biodegradabilidad DQO/DBO5 y el color (VIS436. Adicional a esto, se realizó un ensayo de toxicidad aguda, utilizando bulbos de cebolla común (Allium cepa L. Los resultados mostraron que con una dosis aplicada de ozono de 187 mgO3/h y valores de pH=10 la biodegradabilidad se aumento en un 70% y la toxicidad aguda se redujo en 62%, mientras que para valores de pH =3,0, se favoreció la remoción de la UV254 y el color. La aplicación de ozono demostró ser una alternativa viable para tratar efluentes hospitalarios como pretratamiento de un proceso biológico.

  5. Concepto de “materia laboral” Vigencia material de la ley Nº 18.572

    Directory of Open Access Journals (Sweden)

    Mario Garmendia Arigón

    2014-01-01

    Full Text Available El artículo 7º de la Ley de Abreviación de los Procesos Laborales (Nº 18.572, del 13 de setiembre de 2009 define el “Ámbito de aplicación” utilizando la siguiente fórmula: “Con excepción de lo establecido en normas que prevean procedimientos especiales, en materia laboral el proceso se regirá por lo previsto en esta ley”.Es de hacer notar que el artículo 7º tiene una ubicación incorrecta dentro de la estructura general de la ley 18.572, pues aparece dentro del “Capítulo IV”, intitulado “Proceso laboral ordinario”, cuando, en realidad, su contenido no refiere solamente a esta última estructura procesal, sino a todas las disposiciones procesales consagradas en la ley. (…El análisis que se desarrolla a continuación está centrado, precisamente, en dicha expresión y, en particular, en la vinculación que existe entre el artículo 7º y el artículo 2º de la ley 18.5724, con el propósito de desentrañar si la aplicabilidad de las estructuras procesales que se consagraron en dicha ley queda sólo restringida a las Sedes laborales o si, por el contrario, corresponde entender  que las mismas también deben ser aplicadas por tribunales no pertenecientes a la jurisdicción laboral.

  6. Synthesis of Dithiocarbamate Derivatives of Quinazolinone and Their in vitro Antitumor Activity

    Institute of Scientific and Technical Information of China (English)

    CAO Sheng-Li; FENG Yu-Ping; WAN Rong; LI Run-Tao

    2003-01-01

    @@ Because of the essential role of thymidylate synthase (TS) in DNA biosynthesis, [1] many TS inhibitors have been designed for the treatment of cancer, [2] of which Raltitrexed has been successfully used for the first-line treat ment of advanced colorectal cancer. [3]Acknowledgements We thank National Center for pharmaceutical screening, Institute of Materia Medica, Chi-nese Academy of Medical Sciences, for in vitro antitumor activity screening.

  7. The Advances in Research on the Pharmacological Effects of Fructus Ligustri Lucidi

    Directory of Open Access Journals (Sweden)

    Zunting Pang

    2015-01-01

    Full Text Available Fructus Ligustri Lucidi is a well-known invigorator in Chinese materia medica with hepatoprotective effect, anticancer activity, antioxidant activity, and so on. And oleanolic acids are the major pharmacologically active components in Fructus Ligustri Lucidi. So it has great value in medical health, and may be developed to a complementary and alternative medicine through further research. In this paper, the advances in research on pharmacological effects of Fructus Ligustri Lucidi were summarized by reviewing the recent related literature.

  8. Information for Authors

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    General Asian Journal ofAndrology (AJA) is the official publication of the Asian Society of Andrology sponsored by the Shanghai Institute of Materia Medica, Chinese Academy of Sciences. The Joumal has been included in 11 intemational indexing systems, including BIOSIS, CAB Abstracts, CAB Health, Chemical Abstracts, Current Contents/Clinical Medicine, EMBASE, Index Medicus, MEDLINE, PASCAL, Research Alert, and SCI Expanded. The Impact Factor is 1.064 and ranks third among the intemational andrology ioumals.

  9. Information for Authors

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    1 General Asian Journal of Andrology (AJA) is the official publication of the Asian Society of Andrology sponsored by the Shanghai Institute of Materia Medica, Chinese Academy of Sciences. The Journal has been included in 11 international indexing systems, including BIOSIS, CAB Abstracts, CAB Health, Chemical Abstracts, Current Contents/Clinical Medicine, EMBASE, Index Medicus, MEDLINE, PASCAL, Research Alert, and SCI Expanded. The Impact Factor is 0.827 and ranks third among the international andrology journals.

  10. Information for Authors

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    General Asian Journal ofAndrology (AJA) is the official publication of the Asian Society of Andrology sponsored by the Shanghai Institute of Materia Medica, Chinese Academy of Sciences. The Journal has been included in 11 international indexing systems, including BIOSIS, CAB Abstracts, CAB Health, Chemical Abstracts, Current Contents/Clinical Medicine, EMBASE, Index Medicus, MEDLINE, PASCAL, Research Alert, and SCI Expanded. The Impact Factor is 1.064 and ranks third among the international andrology journals.

  11. LEARNING CHINESE

    Institute of Scientific and Technical Information of China (English)

    1995-01-01

    Vocabulary: 银行 yin hang bank 邮局 you jǔ (you as in "slow") post office 电报 dian bao telegram 邮票 you piao (you as in "know") stamp 信 xin letter 信封 xin feng envelope 航空 hang kong airmail 包裹 bao guo parcel 元 yuan a unit of currency in China 人民币 ren min bi RMB (the name of Chinese currency)

  12. Chinese Weddings

    Institute of Scientific and Technical Information of China (English)

    1997-01-01

    ACCORDING to the Marriage Law of the People’s Republic of China, marital kinship is established and protected by law when a couple registers at tile local marriage registration office. The newly-weds usually hold a wedding feast in celebration at home or in a restaurant. The big red Chinese character, "Double Happiness," would be pasted on walls at the ceremonial hall to

  13. Ethnic Differences And Motivation Based On Maslow’s Theory At a MedicaL University

    Directory of Open Access Journals (Sweden)

    Jagmohni Kaur Sidhu

    2007-06-01

    Full Text Available Introduction: Motivation in Malaysia is to a largeextent influenced by the value system amongst allMalaysians. Being able to motivate employees is one ofthe important keys to the success of the organization.In this paper, an attempt was made to look into theneeds of employees in organizations and in particular,the needs based on Maslow’s theory on motivation. Subjects and Methods: Employees which consisted ofboth academic and administrative employees of theInternational Medical University (IMU were surveyedusing a standard questionnaire. The aim of this studywas to compare which levels of Maslow’s hierarchy ofneeds theory had been fulfilled and which needs wereyet to be fulfilled in the different ethnic groups at IMU. Results: Amongst the males, the Chinese and Indianethnic groups placed most emphasis on the esteem needsand on self-actualization needs. The Malay males gaveimportance to Safety needs. Amongst the female ethnicgroups, all three groups placed most importance on theesteem needs and self-actualization needs. The Chinesefemales scored the lowest for the Basic needs comparedto the Malay and Indian females. The Indian femalesscored the lowest for Social needs.Conclusion: Organisations should play an importantrole in the motivation of employees. Human resourcedevelopment is an integral part in the development ofits employees.

  14. Chinese Culture and Leadership.

    Science.gov (United States)

    Wong, Kam-Cheung

    2001-01-01

    Describes essential characteristics of Chinese philosophical tradition; Discusses Western perspectives on value leadership in education, particularly moral leadership. Discuses moral leadership from a Chinese philosophical perspective, especially Confucianism. Draws implications for using Chinese cultural and philosophical traditions to develop…

  15. CHINESE JOURNAL OF CHEMISTRY

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    @@Chinese Journal of Chemistry is an international journal published in English by the Chinese Chemical Society with its editorial office hosted by Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences.

  16. Određivanje sastava hlapljivih tvari i flavonoida u kori citrona (Citrus medica L. var. Corsican), za procjenu kakvoće likera

    OpenAIRE

    2014-01-01

    U radu je ispitan sastav hlapljivih tvari i flavonoida u kori citrona (Citrus medica L. var. Corsican) uzgojenog na Korzici, različitog stupnja zrelosti izračunatog pomoću sume aktivnih temperatura. Razlike u stupnju razvoja plodova kvantitativno su određene plinskom kromatografijom, plinskom kromatografijom u kombinaciji s masenom spektrometrijom, te tekućinskom kromatografijom praćenom tandemskom masenom spektrometrijom. Identificirano je 30 hlapljivih komponenata eteričnog ulja dobivenog i...

  17. Medicina en la Sociedad Contemporánea Y Educación Medica Continuada

    Directory of Open Access Journals (Sweden)

    Pablo Gómez Martinez

    1987-08-01

    Full Text Available

    Presentado en la ciudad de Lima
    en abril de 1987

    Señores Presidentes de las Academias de Medicina Latinoamericanas.
    Señor Presidente de la Academia Nacional de España.
    Señores Participantes de la IX Reunión Directiva de la ALANAM.

    Señoras y Señores.

    La Academia Nacional de Medicina de Colombia se reunió en varias ocasiones para comentar y discutir el documento suscrito en Buenos Aires el día 15 de noviembre de 1985 sobre el tema LA MEDICINA EN LA SOCIEDAD CONTEMPORANEA.

    Sus varias comisiones estudiaron cuidadosamente las condiciones actuales de la atención médica en el país para proponer medidas adecuadas y una política que permita su realización, cuyas conclusiones nos permitimos presentar a Uds. con la seguridad de que muchas de las fallas de que adolecen nuestros sistemas son comunes a la mayoría de los países latinoamericanos y podrían servir de base para adoptar una filosofía congruente y aceptable sobre la materia.

    Existe en Colombia la Ley 23 de, de Ética Profesional que dice así en su Artículo primero:

    “La medicina es una profesión que tiene como fin cuidar de la salud del hombre y propender por la prevención en las enfermedades el perfeccionamiento de la especie humana y el mejoramiento de los patrones de vida de la colectividad, sin distinción de nacionalidad, ni de orden económico, social, racial, político o religioso. El respeto por la vida y los fueros de la persona humana constituyen su esencia espiritual. Por consiguiente, el ejercicio de la medicina tiene implicaciones humanísticas que le son inherentes”.

    1°. La medicina tiene como objetivo ideal lograr el bienestar físico y espiritual del hombre. Debe, por lo tanto, orientar sus actividades a buscar el mejoramiento permanente de la

  18. The Chinese Banking System

    OpenAIRE

    2012-01-01

    The Chinese banking system is critical to the functioning of the Chinese economy, being the main conduit through which savings are allocated to investment opportunities. Banking activity in China has grown rapidly over the past decade in association with the expansion of the Chinese economy, and the Chinese banking system now includes some of the world’s largest banks. Chinese banks have become more commercially orientated over this period, although the Chinese Government retains considerable...

  19. Comparación de disolventes para la extracción de materias grasas en hígado

    Directory of Open Access Journals (Sweden)

    Carril González-Barros, S. T.

    1996-10-01

    Full Text Available The efficiency of different organic solvents for extraction the fat of pork and veal liver were compared. Soxhlet extraction for 8 hours with n-Hexane: dichloromethane (1:1 was selected. Cv% was 1.9%.

    Se compara la eficacia de extracción de la materia grasa con diferentes disolventes en hígado de cerdo y de ternera. Los resultados más satisfactorios se obtuvieron utilizando un soxhlet con una mezcla de hexano: diclorometano (50:50 durante 8 horas. Se obtuvo un Cv% de 1.9%.

  20. La cláusula general de competencia de los entes territoriales en materia económica

    Directory of Open Access Journals (Sweden)

    Aníbal Zárate

    2012-06-01

    Full Text Available Si la autonomía territorial con que cuentan los entes locales para la “gestión de sus intereses” permite fundar, vía una cláusula general de competencia, las iniciativas económicas locales, esta fórmula aparece sujeta a los límites constitucionales y legales sobre las modalidades de intervención local, como lo sugiere el respeto de las normas nacionales en materia de competencia económica.

  1. Rol del Tribunal Ambiental Administrativo: protección y prevención en materia ambiental

    OpenAIRE

    Rojas, Heilin; Graciela García, Ma.

    2008-01-01

    A través de este artículo, se pretende difundir la existencia de un órgano llamado "Tribunal Ambiental Administrativo" que tutela la legislación ambiental y los recursos naturales donde todo ciudadano, persona física o jurídica puede plantear denuncias cuando existan violaciones en esa materia. Además, se intenta resaltar los aportes que brinda, no solo para Costa Rica, sino a nivel mundial, debido a que la protección y la prevención es responsabilidad de todos. Los gobiernos, el Estado y sus...

  2. CARACTERIZACIÓN ESTRUCTURAL DE LA MATERIA ORGÁNICA DE TRES SUELOS PROVENIENTES DEL MUNICIPIO DE AQUITANIA BOYACÁ, COLOMBIA

    Directory of Open Access Journals (Sweden)

    Carmen S. Mosquera

    2010-09-01

    Full Text Available La materia orgánica del suelo puede variar considerablemente en su estructura, composición y conformación, de acuerdo con el origen y la edad de los materiales que la constituyen. En la presente investigación se procedió a caracterizar, mediante el empleo de la espectroscopia infrarroja y la resonancia magnética nuclear en estado sólido, dos suelos inceptisoles (I01 y I02 y un histosol (H03 destinados al cultivo de cebolla larga, en el municipio de Aquitania-Boyacá, Colombia, a dos profundidades: 0 - 10 y 40 - 50 cm. Según los espectros infrarrojos, se detectó la presencia de grupos OH (debida posiblemente a fenoles, ácidos carboxílicos o alcoholes, grupos aromáticos y alifáticos. Los espectros de 13C-RMN en estado sólido con CPMAS evidenciaron el siguiente orden respecto a la cantidad de carbonos que conforman la materia orgánica del suelo: H03-0 = 100 y H03 -40 = 88, I02-0 = 23 y I02-40 = 0, y finalmente I01-0 = 17 y I01-40 = 12, confirmándose la disminución de carbonos en la materia orgánica a través del perfil del suelo, y además se estableció que el carbón resonante en la región delta = 108-50 ppm de los espectros (N – y O-alquilos y acetales dominó en toda la MOS obtenida; le siguió el carbón aromático (delta = 168-108 ppm para los suelos I01-0 y H03-40, y el carbón alifático (delta = 0-50 ppm para los suelos I01-40, I02-0 y H03-0. Finalmente, el carbónC=O( delta= 220-162 ppm fue el menos dominante en la materia orgánica del suelo en todos los tres suelos caracterizados.

  3. La integración del Reglamento Europeo en materia sucesoria en el Derecho interregional español

    OpenAIRE

    LUIS GARAU JUANEDA

    2015-01-01

    Article 38 of the European Regulation on succession matters alow the non-application of this Regulation to internal conflicts of laws. This paper specifies in which cases we are dealing with an internal conflict of laws and why we must understand that Spain use this possibility. El artículo 38 del reglamento Europeo en materia sucesoria permite excluir de su aplicación los conflictos internos. En este trabajo se precisa en qué casos estamos ante un conflicto interno y por qué debemos ente...

  4. Análisis comparado en materia de obligaciones entre el derecho romano y el derecho moderno

    OpenAIRE

    Luz María Martínez R. de C.; Flor María ávila H de P.

    2008-01-01

    Se realiza un estudio dogmático de los conceptos antiguo y moderno de la "obligación", con especial referencia al Derecho romano, así como a las fuentes y clasificación de las mismas. Del mismo modo, se analiza la influencia del derecho romano en el Código civil venezolano, en materia de obligaciones. En este sentido, la definición romana ha predominado en el Derecho Moderno, incluso en la actualidad se puede afirmar que ha permanecido incólume dentro sus concepciones fundamentales. El método...

  5. La integración del Reglamento Europeo en materia sucesoria en el Derecho interregional español

    Directory of Open Access Journals (Sweden)

    LUIS GARAU JUANEDA

    2015-09-01

    Full Text Available Article 38 of the European Regulation on succession matters alow the non-application of this Regulation to internal conflicts of laws. This paper specifies in which cases we are dealing with an internal conflict of laws and why we must understand that Spain use this possibility. El artículo 38 del reglamento Europeo en materia sucesoria permite excluir de su aplicación los conflictos internos. En este trabajo se precisa en qué casos estamos ante un conflicto interno y por qué debemos entender que España se acoge a esta posibilidad

  6. Herramientas de estudio utilizadas por alumnos de ciencias de la salud en la materia de Anatomía

    OpenAIRE

    Erik Narváez-Hernández; Elvira Ivonne Murillo-Rábago

    2014-01-01

    Introducción : l as herramientas de estudio varían de acuerdo al acceso a la tecnología y pre - supuesto de la Facultad, en Anatomía el uso de modelos virtuales y videos en línea, son una realidad con cada vez mayor uso. Objetivo : Conocer las herramientas de estudio más utilizadas por alumnos que cursaron la materia de Anatomía g eneral en cuanto a tiempo de estudio, tecnología de la información que utilizan, libros preferidos, uso de modelos anatómicos y utilidad de las disecciones. Método ...

  7. EFECTO DEL INJERTO Y NUTRICIÓN DE TOMATE SOBRE RENDIMIENTO, MATERIA SECA Y EXTRACCIÓN DE NUTRIMENTOS

    OpenAIRE

    Heriberto Godoy Hernández; Javier Z. Castellanos Ramos; Gabriel Alcántar González; Manuel Sandoval Villa; José de Jesús Muñoz Ramos

    2009-01-01

    En México la superficie de tomate (Lycopersicon esculentum Mill.) en invernadero ha crecido de forma acelerada. La mayor parte se cultiva en suelo, sin el uso de materia orgánica y con plantas sin injertar, lo que en condiciones de monocultivo suele generar serios problemas de patógenos en la raíz. Una tecnología amigable con el medio ambiente es el uso de portainjertos resistentes a los patógenos del suelo. Es de esperar que esta técnica de producción con plantas de mayor sistema radicular p...

  8. Predicción de precios de materias primas por medio del seguimiento de indicadores económicos

    OpenAIRE

    Gómez Gómez, Daniel

    2015-01-01

    La predicción del comportamiento de la economía mundial se ha hecho más compleja con la globalización de las últimas décadas -- Al tener acceso a información en vivo, todos los fenómenos económicos se transmiten fácilmente de un lado del planeta al otro, afectando los mercados e industrias a un mayor ritmo que anteriormente -- Además de esto, esta sinergia ha llevado a una alta volatilidad de precios de las materias primas -- Sin embargo, existen métodos que permiten hacer un acercamiento a e...

  9. La cláusula general de competencia de los entes territoriales en materia económica

    Directory of Open Access Journals (Sweden)

    Aníbal Rafael Zárate Pérez

    2012-07-01

    Full Text Available Si la autonomía territorial con que cuentan los entes locales para la “gestión de sus intereses” permite fundar, vía una cláusula general de competencia, las iniciativas económicas locales, esta fórmula aparece sujeta a los límites constitucionales y legales sobre las modalidades de intervención local, como lo sugiere el respeto de las normas nacionales en materia de competencia económica.

  10. Caracterización de la materia orgánica en suelos y sedimentos de ambientes estuarinos

    OpenAIRE

    Santín Nuño, Cristina

    2008-01-01

    Los ambientes estuarinos, transicionales entre el medio acuático y terrestre, presentan unas características propias e irrepetibles además de cumplir un elevado número de funciones ecológicas y ambientales. Entre estas se puede destacar la de sus suelos y sedimentos como sumideros de carbono atmosférico. La elevada productividad de sus comunidades vegetales, en conjunción con condiciones geoquímicas que favorecen la lenta descomposición de la materia orgánica, hace que estos suelos y sediment...

  11. La summa divisio iuris público-privado y la integración normativa en materias administrativas y civiles

    Directory of Open Access Journals (Sweden)

    Alejandro Vergara Blanco

    2014-06-01

    Full Text Available La neo-moderna legislación administrativa ha incorporado la necesidad de clasificar la normativa toda en pública o privada, para identificar las normas que, en caso de vacíos (lagunas, cabe aplicar supletoriamente en materia de concesiones de obras públicas y de contratación administrativa. El presente estudio tiene como finalidad ofrecer algunos elementos de análisis de esta nueva situación del esquema normativo chileno.

  12. La summa divisio iuris público-privado y la integración normativa en materias administrativas y civiles

    Directory of Open Access Journals (Sweden)

    Alejandro Vergara Blanco

    2014-07-01

    Full Text Available La neo-moderna legislación administrativa ha incorporado la necesidad de clasificar la normativa toda en pública o privada, para identificar las normas que, en caso de vacíos (lagunas, cabe aplicar supletoriamente en materia de concesiones de obras públicas y de contratación administrativa. El presente estudio tiene como finalidad ofrecer algunos elementos de análisis de esta nueva situación del esquema normativo chileno.

  13. Análisis cognitivo de situaciones problema con sistemas de ecuaciones algebraicas en el contexto del balance de materia

    OpenAIRE

    Elia Trejo Trejo; Patricia Camarena Gallardo

    2011-01-01

    En este artículo se informa una investigación en la que se realiza un análisis cognitivo a un grupo de enfoque, donde los estudiantes de una carrera técnica universitaria abordan los sistemas de ecuaciones algebraicas lineales en el contexto del balance de materia en situaciones problema de mezclas químicas. El análisis cognitivo del grupo de enfoque se fundamenta en las teorías de los Campos Conceptuales y en la Matemática en el Contexto de las Ciencias. Para el análisis se atienden, en part...

  14. A comparative evaluation of ProRoot mineral trioxide aggregate and Portland cement as a pulpotomy medicament

    Directory of Open Access Journals (Sweden)

    Dipti Bhagat

    2016-01-01

    Full Text Available Introduction: Recently, some studies have compared mineral trioxide aggregate (MTA with portland cement (PC, concluding that the principle ingredients of PC are similar to those of MTA. The purpose of the present study was to evaluate the biocompatibility of PC as a pulpotomy medicament. Materials and Methods: Thirty premolars that scheduled for extraction for therapeutic reasons were randomly assigned to two experimental groups: ProRoot MTA (PMTA and PC. After isolation and pulp exposure, pulpotomy was carried out and pulps were dressed with PMTA and PC. After 6 months, the teeth were extracted and prepared for histological analysis based on Cox et al. criteria. The data were analyzed by Z-test of proportion with 1% of allowed error. Results: No statistically significant difference was found between the two groups with respect to inflammatory response, soft tissue organization, and dentine bridge formation (P > 0.05. Conclusions: PC was associated with similar favorable biological response to pulpotomy treatment as PMTA. The findings of this study support the idea that PC can be considered a cheaper substitute to MTA.

  15. Contact sensitization in venous eczema: Preliminary results of patch testing with Indian standard series and topical medicaments

    Directory of Open Access Journals (Sweden)

    Jindal Rashmi

    2009-01-01

    Full Text Available Background and Aims: Elimination of allergens/topical medications causing contact dermatitis in venous eczema, which poses a significant problem in its chronicity and treatment, provides the basis for better therapeutic outcome. Our objective was to determine the pattern of contact sensitization in venous eczema patients in Himachal Pradesh (India. Methods: Thirty-four patients (M:F, 31:3 and 10 controls (M:F, 6:4 were patch tested with Indian standard series and 10 commonly used topical medicaments. Results: Positive patch test results were seen in 50% (M:F, 16:1 of the patients. Common allergens were Fragrance mix (15%, p-phenylendiamine (15%, nickel (9%, wool alcohol (9%, chinoform (9%, balsum of Peru (5%, cobalt chloride (5%, potassium dichromate (3%, epoxy resin (3%, thiuram mix (3% and formaldehyde (3%. Only sisomycin and miconazole among the topical medications elicited a positive patch test reaction in 3 and 5% patients, respectively. Neomycin contact sensitivity was not seen in any of the patients. One patient who had exacerbation of venous eczema following accidental application of topical diclofenac showed a positive patch test reaction to it. Conclusions: Patch test should be used to identify the topical agents that may be responsible for perpetuation or aggravation of eczema, especially in patients who do not improve despite adequate treatment of other underlying cause(s.

  16. A medicação prescrita na internação hospitalar: o conhecimento do cliente

    Directory of Open Access Journals (Sweden)

    Ana Carolina Guidorizzi Zanetti

    2003-12-01

    Full Text Available Erros no processo de administração de medicamentos são preocupações de enfermeiros e a sua ocorrência pode ser minimizada com a orientação do cliente quanto à terapia medicamentosa. Este estudo descritivo, teve como objetivo identificar o grau de informação de clientes hospitalizados, acerca dos medicamentos que lhes são prescritos. A metodologia utilizada foi a exploratória-descritiva. Foram entrevistados 76 clientes adultos, hospitalizados, entre 18 a 60 anos, sendo 69,7% do sexo feminino. Destacou-se dentre outros, que 28% não apresentavam conhecimento acerca do nome do primeiro medicamento prescrito e 55% não souberam referir a dosagem. Detectou-se um número razoável de clientes que desconheciam a medicação prescrita ou tinham conhecimento incorreto. Faz-se necessário a conscientização dos profissionais de enfermagem quanto à importância da orientação ao cliente acerca dos medicamentos durante a internação.

  17. 药用植物灵菊七的染色体核型研究%Study on Chromosomal Karyotypes of Medicinal Plant Gynura medica

    Institute of Scientific and Technical Information of China (English)

    范三微; 董丽辉; 凌庆枝; 屠晓玮; 林芝; 高莉莉; 魏兆军

    2012-01-01

    [目的]研究药用植物灵菊七(Gynura medica)的细胞染色体特点,并对其染色体核型进行分析.[方法]以灵菊七幼苗茎尖为材料,从上午6:30~10:30,每隔20 min取材一次,采用常规制片技术制片,显微镜观察中期分裂相细胞,对染色体完全分散开的细胞进行染色体计数及核型分析.[结果]在染色体分散良好的102个中期分裂相细胞中,有96.08%含20条染色体,3.92%含40条染色体;同时结果表明上午7:50~9:30取材较佳.[结论]G.medica为二倍体植物,体细胞含有10对染色体,核型公式为2n=2x=20 m,染色体核型属于1A型.该研究结果为国内首次报道.%[Objective] To study the chromosomal characteristics and karyotypes of G. medica[Method] Stem tip of G. medica seedlings were collected every 20 rain from 6:30 to 10:30 am, and all materials were treated and squashed for investigating chromcsouud number and karyotypcs analysis. [Result] In tote/102 stem tip cells in metaphase, 96.08% of cells are with 20 chromosomes, and 3.92% of cells are with 40 chromosomes. The optimal time for sampling was from 7:50 to 9:30 am. [Conclusion] G. medica is the diploid plant with 20 chromo-somcs. Karyotype analysis gets formula 2n = 2x = 20 re,and all 10 pairs of chromosomes belong to type IA. The article reported the chromo- somes characteristics of G. medica for the first time in China.

  18. Absolutely Chinese

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    <正>Ink painting animation - an exquisite art form that ends up in a museum Little Tadpole Looking for Mummy Little Tadpole Looking for Mummy, China’s first ink painting animation, was produced in 1961. With innovation in painting, photography and production technology, it was the first effort at ’animating’ ink paintings. Fishes, shrimps, frogs and crabs in the film resemble those in Qi Baishi’s works. By any shot, it’s an animated painting of fishes and insects, one that is suffused with a taste of Chinese ink-and-wash painting.

  19. ‘Usi’ e ‘abusi’ nel diritto: Una riflessione critica sulla normativa in materia di analisi genetiche

    Directory of Open Access Journals (Sweden)

    Salardi Silvia

    2013-01-01

    Full Text Available Al centro di questo contributo vi è l’analisi eticogiuridica degli atti normativi disciplinanti le analisi genetiche in vari contesti, ad esempio, ricerca medica, terapia, medicina legale e così dicendo. Lo scopo è di mettere in evidenza i valori ai quali sono state improntate alcune risposte normative. Pertanto, dopo una ricognizione delle varie tipologie di analisi genetiche e dei loro possibili impieghi, il presente lavoro confronta i testi normativi internazionali, europei e nazionali (Austria, Francia, Germania, Svizzera, al fine di individuare la strada percorsa e da percorrere per salvaguardare il più possibile certi valori ritenuti fondamentali per la preservazione sia dell’autonomia individuale, sia dell’eguaglianza tra i consociati. Si concluderà che non tutte le norme che disciplinano le analisi genetiche possono considerarsi rispettose dei diritti fondamentali garantiti a tutti gli individui.

  20. Chinese letterkunde. Een inleiding

    NARCIS (Netherlands)

    Idema, Wilt; Haft, Lloyd

    2005-01-01

    De Chinese cultuur mag zich verheugen in een groeiende belangstelling. Chinese films bereiken in Nederland een steeds omvangrijker publiek en ook de moderne Chinese literatuur, die sinds de jaren tachtig een grote bloei doormaakt, wordt door veel liefhebbers op de voet gevolgd. Chinese Letterkunde b

  1. Unapal-Dorado, nuevo cultivar de zapallo con alto contenido de materia seca para consumo en fresco

    Directory of Open Access Journals (Sweden)

    Vallejo Cabrera Franco Alirio

    2010-06-01

    Full Text Available A partir de tres cruzamientos dialélicos entre poblaciones con diferente grado de endocría (S0 x S0; S1 x S1; S2 x S2 se seleccionaron 11 familias promisorias teniendo en cuenta el contenido de materia seca, producción por planta y calidad de fruto para consumo en fresco. Se realizaron dos ciclos de recombinación genética y selección ínter e intrapoblacional. Se escogieron cuatro familias las cuales fueron evaluadas en un ensayo de rendimiento en el Centro Experimental de la Universidad Nacional de Colombia sede Palmira (Ceunp. La familia de mejor desempeño se evaluó comparativamente con otras seis, incluyendo el testigo comercial Unapal Bolo Verde, en pruebas regionales, en tres localidades del Valle del Cauca, durante dos semestres consecutivos (2008 B- 2009A. Por su excelente comportamiento en producción (15 kg/planta, contenido de materia seca (> 16%, 3.5 kg/fruto y 5 frutos/planta y calidad de fruto para consumo en fresco, esta familia originó la nueva variedad de zapallo, conocida con el nombre comercial Unapal-Dorado.

  2. Unapal-Dorado, nuevo cultivar de zapallo con alto contenido de materia seca para consumo en fresco

    Directory of Open Access Journals (Sweden)

    Franco Alirio Vallejo C

    2010-04-01

    Full Text Available A partir de tres cruzamientos dialélicos entre poblaciones con diferente grado de endocría (S0 x S0; S1 x S1; S2 x S2 se seleccionaron 11 familias promisorias teniendo en cuenta el contenido de materia seca, producción por planta y calidad de fruto para consumo en fresco. Se realizaron dos ciclos de recombinación genética y selección ínter e intrapoblacional. Se escogieron cuatro familias las cuales fueron evaluadas en un ensayo de rendimiento en el Centro Experimental de la Universidad Nacional de Colombia sede Palmira (Ceunp. La familia de mejor desempeño se evaluó comparativamente con otras seis, incluyendo el testigo comercial Unapal Bolo Verde, en pruebas regionales, en tres localidades del Valle del Cauca, durante dos semestres consecutivos (2008 B- 2009A. Por su excelente comportamiento en producción (15 kg/planta, contenido de materia seca (> 16%, 3.5 kg/fruto y 5 frutos/planta y calidad de fruto para consumo en fresco, esta familia originó la nueva variedad de zapallo, conocida con el nombre comercial Unapal-Dorado.

  3. Il ripensamento e la ridistribuzione suggeriti ai sistemi giuridici liberaldemocratici dalla naturale metamorfosi della domanda di libertà in materia religiosa

    Directory of Open Access Journals (Sweden)

    Sara Domianello

    2011-04-01

    Full Text Available Testo, corredato delle note, dell’intervento al secondo Convegno nazionale di studio dell’A.D.E.C. “Libertà religiosa tra declino o superamento dello Stato nazionale” (Macerata, 28-30 ottobre 2010, destinato alla pubblicazione degli Atti.SOMMARIO: 1. La retromarcia da ingranare (ovvero: il ripensamento circa l’opportunità di trasferire interamente la tutela dei diritti di libertà fondamentali dall’attività parlamentare a quella giurisprudenziale in senso lato – 2. La ristrutturazione da avviare (ovvero: la ridistribuzione delle competenze in materia di pubblico intervento a garanzia dei diritti di libertà in materia religiosa – 3. Il dato da cui muovere (ovvero: la metamorfosi della domanda di libertà in materia religiosa nei sistemi liberaldemocratici.

  4. Management of Chinese restaurant

    OpenAIRE

    Cui , Longbo

    2009-01-01

    With Chinese economy developing rapidly, the Chinese restaurant is under the spotlight, but the management of Chinese restaurant is weak at the moment, especially on the service management, which is an important part of service management in the Chinese restaurant. On the other hand, the managers of Chinese restaurant should pay more attention on the service management for instance brand, service innovation. Service management is core and essential concept for every service company recently, ...

  5. Importancia de las asignaturas y materias del currículum en la formación de los profesionales de enfermería

    OpenAIRE

    Pérez Cañaveras, Rosa María; Juan Herrero, Joaquín de

    1994-01-01

    La relevancia de los contenidos del currículum ha sido objeto de estudio en Medicina, sin embargo no hay datos publicados referentes a las asignaturas y materias en la carrera de Enfermería. El objetivo de este trabajo es determinar el grado de importancia relativa que un buen número de asignaturas y materias de los actuales curricula de Enfermería, tienen en la formación de dichos profesionales. Este objetivo adquiere mayor relevancia dada la progresiva puesta en marcha de los nuevos planes ...

  6. Evaluación de fuentes de materia orgánica fecal como inóculo en la producción de metano

    OpenAIRE

    Olivia García-Galindo; Aurelio Pedroza-Sandoval; José Antonio Chávez-Rivero; Ricardo Trejo-Calzada; Ignacio Sánchez-Cohen

    2015-01-01

    Las energías alternativas están tomando auge ante los altos costos de los hidrocarburos fósiles y el impacto ambiental. El objetivo de este estudio fue determinar la mejor fuente de materia orgánica fecal como inóculo inicial a diferentes temperaturas en la producción de metano. Se establecieron reactores Batch de 1 000 ml en condiciones in vitro , a los cuales se les adicionó materia orgánica fecal y una solución microbiana como inóculo inicial. Se usó un diseño en ...

  7. Incorporación de la dinámica grupal en la materia resolución de problemas y algoritmos

    OpenAIRE

    2004-01-01

    Siguiendo nuestra línea de investigación que apunta al desarrollo de plataformas de educación a distancia y teniendo como meta el dictado del Profesorado en Informática para Enseñanza Media a distancia, hemos trabajado en diversas herramientas y propuestas metodológicas que utilizan la Dinámica Grupal y que tienden a mejorar el proceso de enseñanzaaprendizaje de la s materias de dicha carrera. Tomamos como punto de partida la materia Resolución de Problemas y Algoritmos y desarrollamos una...

  8. 热者寒之细胞中药学初探%Exploring cytological effect of Chinese material medica by treating hot syndrome with cold drugs

    Institute of Scientific and Technical Information of China (English)

    王征; 张宁; 王翠玲; 刘竹兰; 刘建利

    2015-01-01

    Objective To test whether the traditional therapeutic rule“to treat hot syndrome with cold drugs”can ap-ply to the hot syndrome cell model which was established with hot drugs. Methods Five hot herbal drugs white Peper (50 μg / mL),Piper longum L.(50 μg / mL),Alpinia officinarum Hance(100 μg / mL),Evodia rutaecarpa(Juss. ) Benth(10 μg / mL)and Cinnamomum cassia presl.(20 μg / mL)were used to treat the cell to induce hot model. Then three cold herbal drugs Coptis Chinensis Franch,Povygonum cuspidatum sieb,et. Zucc and Cynanchum atratum Bge. 5- 800 μg / mL were used to reverse models. Result Three cold herbal drugs could completely cure the hot syndrome and the results were in accordance with that obtained on animal model. Conclusion The traditional therapeutic rule“to treat hot symptom with cold drug”can apply on cell model.%目的:用热药造热证细胞模型,研究“热者寒之”的基本治则对于细胞来说是否适用。方法分别用白胡椒50μg / mL、荜菝50μg / mL、高良姜100μg / mL、吴茱萸10μg / mL、肉桂20μg / mL 进行造模,再以黄连、虎杖、白薇3味寒药分5~800μg / mL 8个浓度梯度分别进行逆转。结果黄连、虎杖和白薇对5种热药所造模型可以完全逆转,这与动物实验结果一致。结论“热者寒之”这一中医基本治则在细胞水平上是适用的,并将丰富细胞中药学的内容。

  9. Comparative Evaluation of Propolis, Metronidazole with Chlorhexidine, Calcium Hydroxide and Curcuma Longa Extract as Intracanal Medicament Against E.faecalis– An Invitro Study

    Science.gov (United States)

    Nair, Rashmi; Asrani, Hemant

    2015-01-01

    Introduction The increase of potential side effects and safety concerns of conventional medicaments have led to the recent popularity of herbal alternative medications. The herbal products are known for its high antimicrobial activity, biocompatibility, anti-inflammatory and antioxidant properties. Aim The purpose of this study was to investigate and compare the effectiveness of Propolis, Metronidazole with Chlorhexidine gel, Curcuma Longa and Calcium Hydroxide for elimination of E.faecalis bacteria in extracted teeth samples. Materials and Methods Ninety extracted single rooted intact teeth were taken for the study. Decoronation, removal of apices and chemomechanical preparation was done for all samples. These sterilized samples were then contaminated with pure culture of E.faecalis under laminar flow. The samples were incubated for a period of 21 days. The infected samples were assigned to 5 groups: Group I- Propolis; Group II- Metronidazole with Chlorhexidine gel; Group III- Calcium hydroxide; Group IV- Curcuma Longa; and control group- Saline. Efficacy of newer intracanal medicaments against E.faecalis were carried out in the samples at the end of 1, 2 & 5 days for each group with the help of colorimeter. Student paired t-test, ANOVA and multiple tukey test were used for statistical analysis. Results The value of optical density was statistically significant in all groups when compared to that of control group. Group I (Propolis) produced better antimicrobial efficacy followed by Chlorhexidine Metronidazole combination, Curcuma Longa and Calcium hydroxide. Conclusion Within the limitations of this study, it can be concluded that Propolis showed better antimicrobial properties against E.faecalis than other medicaments. PMID:26673857

  10. Sentimentos de profissionais de enfermagem após a ocorrência de erros de medicação

    OpenAIRE

    Santos,Jânia Oliveira; Silva,Ana Elisa Bauer de Camargo; Munari,Denize Bouttelet; Miasso,Adriana Inocenti

    2007-01-01

    OBJETIVO: Conhecer os sentimentos dos profissionais de enfermagem que cometeram erro de medicação. MÉTODOS: Estudo descritivo, qualitativo, realizado com 15 profissionais de enfermagem de um hospital universitário de Goiânia. Os dados foram coletados através de entrevistas semi-estruturadas, gravadas e analisadas segundo os pressupostos de Bardin. RESULTADOS: Os resultados mostraram que os sentimentos mais comuns são pânico, desespero, medo, culpa, vergonha, entre outros. Adotam, como estraté...

  11. Nuevos desarrollos en la cooperación jurídica internacional en materia civil y comercial

    Directory of Open Access Journals (Sweden)

    Ignacio Goicoechea

    2016-05-01

    Full Text Available El propósito de este trabajo es señalar el desarrollo que ha tenido la Cooperación Jurídica Internacional en los últimos tiempos. Destacando su vínculo con la protección de los derechos humanos y el desarrollo de los negocios internacionales, y presentando las nuevas herramientas que se están utilizando en esta materia para hacerla más rápida y eficiente. Finalmente se alienta a los actores a que las utilicen de la forma más amplia y creativa posible, y cuando resulte apropiado se legisle de manera de facilitar un mayor uso y amplia difusión de las mismas.

  12. La acción del Estado colombiano en materia de derechos humanos: un camino en construcción

    Directory of Open Access Journals (Sweden)

    Patricia Herrera Kit

    2010-11-01

    Full Text Available El presente documento se constituye en un avance de investigación cuyo enfoque está guiado por el interés de indagar sobre la función que desempeñan los derechos humanos en el Estado colombiano. De esta forma, a partir de la revisión del proceso de positivización e internacionalización de los derechos humanos y las dificultades que éste experimenta en la esfera internacional, el documento avanza en analizar algunos de los elementos que caracterizan la respuesta del Estado colombiano en la materia a partir de la Constitución de 1991.

  13. Análisis de las Relaciones Bilaterales entre México Y Estados Unidos en materia de lucha antidrogas, durante el periodo 2006–2010

    OpenAIRE

    2011-01-01

    Monografia de Grado sobre la cooperación bilateral entre Mexico y Estados Unidos en materia de seguridad desde el 2006 al 2010. Análisis a las políticas del gobierno de Felipe Calderon, George W. Bush y Barack Obama.

  14. Happy (Chinese) New Year!

    Science.gov (United States)

    Johnson, Georgia G.

    1979-01-01

    Suggestions are made for a classroom celebration of Chinese New Year, including discussion of the Chinese calendar and customs, a short list of appropriate children's stories, and food ideas, including a recipe for fortune cookies. (SJL)

  15. Scanorama in Chinese

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ Scanorama, the SAS on-board magazine,is now also available in Chinese. Table-tennis star,J-O Waldner, Scandinavian design and delicious Norwegian seafood are what SAS Chinese customers can read about while sitting on board SAS flights on the Copenhagen - Beijing and Copenhagen-Shanghai routes. The magazine uses the written Chinese language that is read by nearly one billion mainland Chinese.

  16. On Chinese Character

    Institute of Scientific and Technical Information of China (English)

    杨文娟

    2016-01-01

    Just as the long history of our country, Chinese characters also have their long histories through thousands of years. There have been many great scientific works or documents studying on the origin of Chinese characters. From them, it can easily be found that each Chinese character has its own history. If we study on the history of a specific Chinese character, its motivation will be found.

  17. Sequential cloud-point extraction for toxicological screening analysis of medicaments in human plasma by high pressure liquid chromatography with diode array detector.

    Science.gov (United States)

    Madej, Katarzyna; Persona, Karolina; Wandas, Monika; Gomółka, Ewa

    2013-10-18

    A complex extraction system with the use of cloud-point extraction technique (CPE) was developed for sequential isolation of basic and acidic/neutral medicaments from human plasma/serum, screened by HPLC/DAD method. Eight model drugs (paracetamol, promazine, chlorpromazine, amitriptyline, salicyclic acid, opipramol, alprazolam and carbamazepine) were chosen for the study of optimal CPE conditions. The CPE technique consists in partition of an aqueous sample with addition of a surfactant into two phases: micelle-rich phase with the isolated compounds and water phase containing a surfactant below the critical micellar concentration, mainly under influence of temperature change. The proposed extraction system consists of two chief steps: isolation of basic compounds (from pH 12) and then isolation of acidic/neutral compounds (from pH 6) using surfactant Triton X-114 as the extraction medium. Extraction recovery varied from 25.2 to 107.9% with intra-day and inter-day precision (RSD %) ranged 0.88-1087 and 5.32-17.96, respectively. The limits of detection for the studied medicaments at λ 254nm corresponded to therapeutic or low toxic plasma concentration levels. Usefulness of the proposed CPE-HPLC/DAD method for toxicological drug screening was tested via its application to analysis of two serum samples taken from patients suspected of drug overdosing.

  18. 植物药对他克莫司血药浓度的影响%Influence of planta medica on the blood concentration of tacrolimus

    Institute of Scientific and Technical Information of China (English)

    逄晓云; 沈金芳

    2009-01-01

    他克莫司是一种器官移植患者广泛使用的免疫抑制剂,大大提高了患者的生活质量和生存率.目前,越来越多的学者关注到西药和他克莫司的相互作用,然而,关于植物药与其相互作用的系统研究很少.本文就植物药与他克莫司的相互作用进行探讨.%Tacrolimus is an widely used immuno-suppressant in organ transplant patients for anti-rejection , and the quality of life and survival rate are greatly enhanced. At present, a growing number of scholars concerned with drug interactions of Western medicine and tacrolimus. However, the impact of planta medica on it was rarely systematically overviewed. This article explored the interaction of planta medica and tacrolimus.

  19. TRADITIONAL CHINESE HERBAL MEDICINE

    NARCIS (Netherlands)

    ZHU, YP; WOERDENBAG, HJ

    1995-01-01

    Herbal medicine, acupuncture and moxibustion, and massage and the three major constituent parts of traditional Chinese medicine. Although acupuncture is well known in many Western countries, Chinese herbal medicine, the mos important part of traditional Chinese medicine, is less well known in the We

  20. Chinese restaurant syndrome

    Directory of Open Access Journals (Sweden)

    Balachandran C

    1991-01-01

    Full Text Available A 24-year-old Chinese student with history of recurrent attacks of flushing with burning and dryness of face of 4 years duration showed exacerbation of the symptoms after oral provocation with 1 mg of Chinese salt. Patient was treated with 50 mg pyridoxine daily and restriction of the Chinese salt in diet with moderate improvement.

  1. Chinese Lunar Calendar

    Institute of Scientific and Technical Information of China (English)

    方陵生

    2005-01-01

    @@ Background and Concept The Chinese animal signs2 are a 12-year cycle used for dating the years. They represent a cyclical concept of time, rather than the Western linear concept of time. The Chinese Lunar Calendar is based on the cycles of the moon, and is constructed in a different fashion than the Western solar calendar3. In the Chinese calendar, the beginning of the year falls somewhere between late January and early February. The Chinese have adopted the Western calendar since 1911,but the lunar calendar is still used for festive occasions such as the Chinese New Year. Many Chinese calendars will print both the solar dates and the Chinese lunar dates.

  2. Chinese Wrestling,Chinese Traditional Spirit to Be Succeeded

    Institute of Scientific and Technical Information of China (English)

    Sun Yongjian; Guo Yan

    2006-01-01

    @@ Chinese Wrestling which has been exercised for thousands of years, has a history of as long as the Chinese People China's Foreign Trade exclusively interviewed 72-year old Mr. Li Baoru, Head of the Chinese Wrestling Team. He stressed: "Chinese Wrestling will not become extinct, because it is the symbol of the Chinese Spirit."

  3. Disinfection of dentinal tubules with two different formulations of calcium hydroxide as compared to 2% chlorhexidine: As intracanal medicaments against Enterococcus faecalis and Candida albicans: An in vitro study

    Directory of Open Access Journals (Sweden)

    Dakshita Joy Vaghela

    2011-01-01

    Full Text Available Aim: To evaluate the disinfection of dentinal tubules using calcium hydroxide with propylene glycol and calcium hydroxide with iodoform in silicone oil, as compared to 2% chlorhexidine gel. Materials and Methods: The antimicrobial efficacy of the medicaments against E.faecalis and C.albicans were assessed in vitro, using a dentinal tubule model at depths of 200 μm and 400 μm in extracted single rooted teeth. Saline was taken as the negative control (Group I Results: All three medicaments used in this study exerted antibacterial and antifungal activity. Group II (calcium hydroxide with propylene glycol and Group IV (2% chlorhexidine gel had the highest antimicrobial activity and the differences between their antibacterial activities were not statistically significant. Group III (calcium hydroxide with iodoform in silicone oil and Group IV had the highest antifungal activity and the differences between their antifungal activities were not statistically significant. The inhibition of growth at 200 μm and 400 ΅m was uniform, with no statistical difference. Conclusions: Two percent chlorhexidine gel was effective against both E.faecalis and C.albicans. Calcium hydroxide with propylene glycol was the most effective intracanal medicament along with 2% chlorhexidine against E.faecalis, whereas, calcium hydroxide with iodoform in silicone oil was the most effective intracanal medicament along with 2% chlorhexidine against C.albicans.

  4. Fatores preditores e conseqüências clínicas do uso de múltiplas medicações entre idosos atendidos em um serviço ambulatorial de saúde mental

    Directory of Open Access Journals (Sweden)

    Almeida Osvaldo P.

    1999-01-01

    Full Text Available OBJETIVO: Investigar o padrão de uso de medicamentos, polifarmácia e uso impróprio de medicações entre indivíduos com 60 anos ou mais atendidos no serviço ambulatorial de saúde mental da Santa Casa de São Paulo, Brasil. MÉTODOS: Cento e oitenta e quatro pacientes atendidos de forma consecutiva foram avaliados sistematicamente quanto à dosagem e tempo de utilização de medicamentos na semana que antecedeu a consulta médica. A presença de sintomas físicos e psicológicos foi avaliada com a escala Saftee-Up simplificada. O uso impróprio de medicamentos foi avaliado através dos critérios de Stuck modificado. RESULTADOS: O número médio de medicações consumidas por paciente foi de 2,46 - 41,3% dos entrevistados utilizavam três ou mais medicamentos e 10,9% utilizavam cinco ou mais medicações por dia. Antidepressivos (42,4%, drogas anti-hipertensivas (32,6% e benzodiazepínicos (21,2% eram as medicações mais freqüentemente utilizadas. Pacientes utilizando três ou mais medicações apresentavam escores mais elevados na escala Saftee-Up (p=0,007. Análise de regressão logística indicou que os escores da Saftee-Up eram influenciados de forma significativa pelo número de diagnósticos clínicos (OR=1,85, p=0,030, mas não pela idade (OR=0,99, p=0,732, sexo (OR=0,67, p=0,317, número de diagnósticos psiquiátricos (OR=0,77, p=0,533 ou de medicações (OR=1,18, p=0,258. Trinta e quatro idosos (18,5% vinham utilizando pelo menos uma medicação considerada imprópria. CONCLUSÕES: É importante que os psiquiatras estejam cientes das diretrizes internacionais para prescrição de drogas e participem ativamente para reduzir os riscos associados à polifarmácia e uso impróprio de medicamentos em idosos.

  5. Relación entre el poder ejecutivo y el poder legislativo en materia de política exterior, el caso de Vicente Fox (2000-2006)

    OpenAIRE

    Roberto Rafael Reyes Díaz

    2012-01-01

    Este documento tiene por objetivo presentar la interrelación en materia de política exterior entre el poder ejecutivo y el poder legislativo durante el periodo 2000-2006. En ésta se manifestó una compleja relación entre poderes derivada de las facultades constitucionales de cada institución que participa en la elaboración, ejecución y evaluación de la política exterior. Además, se expondrá el control legislativo en la materia a través de los resultados del análisis de comparecencias, puntos d...

  6. Relación entre el poder ejecutivo y el poder legislativo en materia de política exterior, el caso de Vicente Fox (2000-2006

    Directory of Open Access Journals (Sweden)

    Roberto Rafael Reyes Díaz

    2012-01-01

    Full Text Available Este documento tiene por objetivo presentar la interrelación en materia de política exterior entre el poder ejecutivo y el poder legislativo durante el periodo 2000-2006. En ésta se manifestó una compleja relación entre poderes derivada de las facultades constitucionales de cada institución que participa en la elaboración, ejecución y evaluación de la política exterior. Además, se expondrá el control legislativo en la materia a través de los resultados del análisis de comparecencias, puntos de acuerdos e iniciativas de modificaciones jurídicas para el consenso de la política internacional.

  7. Utilización de cenizas volantes y mineralizadores como materia prima en la fabricación de cemento

    Directory of Open Access Journals (Sweden)

    Palomo Sánchez, Ángel

    1983-03-01

    Full Text Available In this research the process of formation of a low energy clinker is studied, when fly-ashes (rich in sulphates and lime and fluorspar are used as raw materials (fly-ashes replaces to the tradicional raw mix partially. The availability of those fly-ashes is shown since clinker at 1.340 °C is obtained. The mineralogical composition, mineralizer capacity and temperature of formation of the new liquid phase is studied.

    En el presente trabajo se estudia el proceso de formación de un clínker de bajo consumo energético, empleando como materia prima cenizas volantes sulfocálcicas (en sustitución parcial del crudo tradicional y fluorita. Se demuestra la validez de dichas cenizas volantes, obteniendo clínker a 1.340 °C. Se estudia la composición mineralógica, capacidad de mineralización y temperatura de formación de la nueva fase líquida.

  8. Conocimiento previo y comprensión lectora en un texto de materia teológica

    Directory of Open Access Journals (Sweden)

    Silvia Méndez Anchía

    2007-01-01

    Full Text Available Estudio el libro Cristología, fe de Jesús, fe cristiana, de Francisco Avendaño Herrera (San José: UNED, 2002, para determinar cómo influyen los conocimientos previos del estudiantado (asociados con una perspectiva tradicionalista en su comprensión lectora del conocimiento nuevo que presenta el texto de Avendaño. Recolecté los datos mediante observación participante en las tutorías del curso de Cristología en que se utiliza el texto (programa de Teología a Distancia de la UNED y la UNA, ambas instituciones de educación superior de Costa Rica. Analizo los resultados con base en tres posibles formas de lectura: autoritaria, negociada y competente. Concluyo señalando un predominio de la lectura autoritaria y negociada, que puede explicarse por la función social de la religión en la construcción de la realidad de los sujetos, razón por la cual estos parecen resistirse a comprender un conocimiento nuevo que les genera incertidumbre en su visión de mundo en materia religiosa. Emito, finalmente, una serie de recomendaciones sobre cambios que, con base en los resultados de este estudio, podrían introducirse en una nueva edición del libro analizado.

  9. OXIDACIÓN DE MATERIA ORGÁNICA PERSISTENTE EN AGUAS RESIDUALES INDUSTRIALES MEDIANTE TRATAMIENTOS ELECTROQUÍMICOS

    Directory of Open Access Journals (Sweden)

    Ivonne Linares-Hernández

    2011-01-01

    Full Text Available El objetivo de esta investigación fue implementar un sistema electroquímico, mediante tratamientos de electrocoagulación, empleando electrodos de hierro y oxidación anódica directa (OAD, empleando electrodos de diamante dopados con boro (DDB, para tratar aguas residuales provenientes de una planta de tratamiento que recibe las descargas de 144 empresas de diferentes giros, de la zona industrial Toluca-Lerma, México. Los resultados de estos tratamientos, indicaron una remoción del 99% de la demanda química de oxígeno (DQO, 99% de color y 97% de turbidez, en un tiempo de 2 h. En el sistema acoplado, la electrocoagulación removió las partículas coloidales y suspendidas y la OAD, permitió la degradación de materia orgánica persistente. Se determinó la cantidad de lodos generados en el sistema y se caracterizaron por microscopia electrónica de barrido y análisis elemental. Se concluye que los métodos electroquímicos resultan ser aplicables y eficientes en la degradación compuestos que no son fácilmente biodegradables.

  10. Análisis comparado en materia de obligaciones entre el derecho romano y el derecho moderno

    Directory of Open Access Journals (Sweden)

    Luz María Martínez R. de C.

    2008-05-01

    Full Text Available Se realiza un estudio dogmático de los conceptos antiguo y moderno de la "obligación", con especial referencia al Derecho romano, así como a las fuentes y clasificación de las mismas. Del mismo modo, se analiza la influencia del derecho romano en el Código civil venezolano, en materia de obligaciones. En este sentido, la definición romana ha predominado en el Derecho Moderno, incluso en la actualidad se puede afirmar que ha permanecido incólume dentro sus concepciones fundamentales. El método utilizado es el descriptivo y documental. Se concluye que las definiciones de las obligaciones en el Derecho Moderno se limitan a reproducir los principios inspiradores romanos y que nuestro Código civil recibió una fuerte influencia del Proyecto Franco-Italiano de las Obligaciones, en el cual se desarrolló el concepto y los efectos de determinadas figuras productoras de obligaciones.

  11. CHIRAL FIELD IDEAS FOR A THEORY OF MATTER IDEAS DE CAMPO QUIRAL PARA UNA TEORÍA DE LA MATERIA

    Directory of Open Access Journals (Sweden)

    Héctor Torres-Silva

    2008-11-01

    Full Text Available In this paper, a chiral approach is used for developing a unified theory of electromagnetic and gravity fields. The photons which satisfy Maxwell's equations for an electromagnetic wave are taken as the basic physical components. The goal of the theory is to unify the phenomena of relativistic invariance, wave mechanics and pair creation with Maxwell's equation to obtain an electromagnetic field theory of matter. With this theory some aspects of GPS (Global Positioning Systems systems are discussed.En este trabajo, para el desarrollo de una teoría unificada de campos electromagnéticos y gravitacionales se usa un método quiral. Los fotones que satisfacen las ecuaciones de Maxwell, para una onda electromagnética se consideran como componentes físicos básicos. El objetivo de esta teoría es unificar el fenómeno de la invarianza relativística, mecánica de onda y la creación del par electrón positrón, con las ecuaciones de Maxwell, para obtener una teoría de la materia totalmente electromagnética. Considerando esta teoría se discuten algunos aspectos de los sistemas GPS (Global Positioning Systems.

  12. TRANSPORTE DE MATERIA ORGÁNICA A LO LARGO DE UN RÍO TROPICAL DE MONTAÑA EN LA SIERRA NEVADA DE SANTA MARTA (COLOMBIA

    Directory of Open Access Journals (Sweden)

    Cesar Enrique TAMARIS TURIZO

    2015-01-01

    Full Text Available En los ríos tropicales, la materia orgánica es la principal fuente de energía para las comunidades que allí habitan. Las principales proporciones de materia orgánica se encuentra la materia orgánica particulada gruesa (MOPG y la materia orgánica particulada fina (MOPF. Por lo anterior, en este trabajo se evaluó el transporte de la MOPG, la MOPF y su relación con algunas variables físicas y químicas en tres tramos de un gradiente altitudinal de los 50 msnm hasta los 1700 msnm durante un ciclo diario en el río Gaira (Sierra Nevada de Santa Marta. Para lo cual se realizaron muestreos mensuales entre los meses de marzo a junio del 2008. Se detectaron diferencias significativas en la deriva de MOPG entre las estaciones, siendo la estación 2 (parte media durante el primer muestreo, la que registró los valores más altos reportados para todo el estudio (474 kg m -3 y la estación 3 mostró la menor biomasa derivante (0.26 kg m -3 . La MOPF registró valores similares durante todos los muestreos (0.58 – 6.34 g m -3 . Sin embargo, se detectaron diferencias significativas en los muestreos tres y cuatro. Con el aumento de las lluvias, descendió el transporte de MOPG. Una relación inversa entre la velocidad del agua y el transporte de MOPG (rs = -0,70; n = 12; p < 0,05 se registró, mientras que la MOPF, presentó valores constantes. Los resultados de este trabajo coinciden parcialmente con lo registrado en la literatura, lo cual indica que las dinámicas de transporte de MO están relacionadas con las variaciones ambientales locales.

  13. Efectos Jurídicos del Uso Excesivo de Facultades del Poder Ejecutivo delegadas por el Legislativo, en Materia de Salud

    OpenAIRE

    Ticona Román, Óscar Favio

    2015-01-01

    En la presente tesis, expondremos el problema del uso excesivo de facultades que realiza el Poder Ejecutivo, cuando este solicita al Legislativo el otorgamiento de facultades para normar decretos legislativos para ciertos puntos de trascendencia, esta vez referente al Sector Salud. En efecto, mediante Ley Nro. 30073, el Legislativo otorga facultades al Ejecutivo para que legisle sobre determinadas materias, entre éstas el de fortalecimiento del sistema nacional de salud, ...

  14. Estudio comparado sobre igualdad de género en materia laboral: los casos de alemania, kazajstán y méxico.

    OpenAIRE

    Sigmond Ballestros, Karen; Cernas Díaz, Luis Antonio; Bambrila Paz, Carlos

    2013-01-01

    El propósito de esta investigación es proveer al lector una visión comparativa del progreso en materia de igualdad de género plasmado en el contenido de las leyes laborales, a través del espíritu normativo de las Constituciones y las principales normas de la República Federal de Alemania, la República de Kazajstán y México.

  15. Propuestas de reforma a la Ley Federal del Trabajo en materia de condiciones de trabajo y salud laboral, sustentadas en instrumentos internacionales suscritos por México

    OpenAIRE

    Karina Trejo Sánchez

    2009-01-01

    Por mandato constitucional, la observancia de los tratados internacionales es obligatoria. En estos términos, si las disposiciones de nuestro derecho interno consagran menores prerrogativas para los trabajadores en materia de condiciones de trabajo y salud laboral, es menester que las disposiciones de dichos instrumentos internacionales sean incorporadas a la Ley Federal del Trabajo para otorgar más garantías a los trabajadores.

  16. Lista de encabezamientos de materia de la Red de Bibliotecas del Consejo Superior de Investigaciones Científicas (España)

    OpenAIRE

    González Sereno, Elvira; Soria González, Inocencia

    1996-01-01

    El Consejo Superior de Investigaciones Científicas (CSIC) es el organismo público de investigación más importante de España por su volumen de recursos y actividades. Su quehacer científico se caracteriza por la multidisciplinariedad. La lista de encabezamientos de materia de la Red de Bibliotecas del CSIC pretende dar respuesta a los usuarios presentando cada vez nuevas ediciones mejoradas y aumentadas.

  17. Citrus medica L. cv Diamante (Rutaceae) peel extract improves glycaemic status of Zucker diabetic fatty (ZDF) rats and protects against oxidative stress.

    Science.gov (United States)

    Menichini, Francesco; Tundis, Rosa; Loizzo, Monica R; Bonesi, Marco; D'Angelo, Danila; Lombardi, Pietro; Mastellone, Vincenzo

    2016-12-01

    This study aimed to investigate the antidiabetic, antilipidaemic and antioxidant activities of Citrus medica cv Diamante (Rutaceae) hydroalcoholic (CD) peel extract in Zucker diabetic fatty (ZDF) rats. The ability of CD to protect against oxidative stress was investigated by using different in vitro assays and in vivo by using the reactive oxygen metabolites-derived compounds (d-ROMs) test and the biological antioxidant potential test (BAP). Two different doses of CD extract (300 and 600 mg/kg/die) were administered at ZDF rats for 4 weeks. CD reduced cholesterol and triglycerides levels. A dose-dependent effect on body weight and serum glucose levels was observed. A decrease of d-ROMs and an increase of BAP were recorded by using the dose of 600 mg/kg. The extract inhibited lipid peroxidation (IC50 value of 0.23 mg/ml). These findings suggest as an efficient phytotherapeutic approach in combating hyperlipidaemic and hyperglycaemic disorders.

  18. Recovery e medicação: Perspectivas e percepções de indivíduos com experiência de doença mental

    OpenAIRE

    Mendes, Carla Sofia Almeida e

    2008-01-01

    Dissertação de Mestrado em Psicologia Comunitária Sendo notória a pertinência das questões relacionadas com a saúde mental dada a sua elevada incidência à escala mundial, surgem novos debates em torno do conceito emergente de recovery. A relação entre a medicação psiquiátrica e o recovery é um tema complexo e controverso, estando a área da saúde mental repleta de relatos que salientam o valor dos medicamentos no recovery e, em simultâneo, de opiniões que testemunham uma posição contrária à...

  19. Espacio y materia en la percepción poética y artística de José Ángel Valente

    Directory of Open Access Journals (Sweden)

    Ching Yu Lin

    2015-04-01

    Full Text Available La poesía de José Ángel Valente plantea temáticas fundamentales sobre el  espacio y la materia, conjugando voz poética y pensamiento artístico y filosófico. Nos revela el sentido de las formas del arco y del círculo a través de la sabiduría taoísta y del Zen. Compone poemas para responder al concepto de materia de artistas españoles, tales como Eduardo Chillida, Luis Fernández y Antoni Tàpies. Desde la perspectiva ética, en el poema «Hibakusha», la materia de Valente ofrece experiencias acústicas, que constituyen un espacio de la memoria histórica y una representación del ser humano. Nos invita a escuchar el espacio material y corporal, destruido por bombas atómicas.

  20. CHINESE OF HUMANITY

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    A discussion of chinese curriculum of primary school under the background of new curriculum reform Mao xinjuan Feng haiying [Abstract] in recent years, Chinese learning received more and more attention by people article mainly from the national studies this course concepts, the curriculum reform of elementary school curriculum requirements and how to effective implementation of primary national studies course several aspects under the background of curriculum reform of Chinese primary curriculum the new school

  1. A pré-medicação com midazolam antes de secção cesariana não tem efeitos adversos no neonato

    Directory of Open Access Journals (Sweden)

    Ahmet Can Senel

    2014-01-01

    Full Text Available Como todos os pacientes cirúrgicos, pacientes obstétricas também sentem estresse e ansieda de operatórios. Isso pode ser prevenido se forem passadas à paciente informações detalhadas sobre sua operação e se forem administrados medicamentos farmacológicos pré-operatórios. Devido aos efeitos depressivos dos sedativos nos neonatos, os medicamentos farmacológicos são omitidos, especialmente em pacientes obstétricas. A literatura contém poucos estudos concernentes ao uso de midazolam no pré-operatório em pacientes de secção cesariana (C/S. Nosso objetivo nesse estudo foi ajudar nossas pacientes passando por cirurgia C/S. Um grupo agendado para C/S eletiva recebeu midazolam 0,025 mg kg−1 por via intraveno sa; o outro grupo recebeu salina. A ansiedade materna foi avaliada com o uso dos escores da Amsterdam Preoperative Anxiety and Information Scale (APAIS (Escala de Ansiedade e Informação Pré-operatória de Amsterdam, e os neonatos foram avaliados por Apgar e pelo instrumento Neonatal Neurologic and Adaptive Capacity Score (NACS (Escore Neurológico e de Capacidade Adaptativa do Neonato. Em conclusão, os pacientes pré-medicados com midazolam 0,025 mg kg−1 medicação tiveram escores de ansiedade significativamente baixos, sem qualquer efeito adverso nos neonatos. Portanto, midazolam pode, com segurança, ser utilizado como agente de pré-medicação na cirurgia C/S.

  2. Funcionamento intelectual em pacientes pediátricos com epilepsia: comparação de crianças controladas com medicação, não controladas com medicação e controladas com cirurgia Intellectual functioning in pediatric patients with epilepsy: a comparison of medically controlled, medically uncontrolled and surgically controlled children

    Directory of Open Access Journals (Sweden)

    Cecília Souza-Oliveira

    2010-10-01

    Full Text Available OBJETIVO: Comparar o quociente intelectual (QI em três grupos de crianças com epilepsia: 1 controlados com medicação, 2 não controlados com medicação e 3 controlados com cirurgia. MÉTODOS: Noventa e oito pacientes pediátricos, com idades entre 6 e 12 anos, foram selecionados de dezembro de 2007 a julho de 2008. A Escala de Inteligência Wechsler para Crianças - terceira edição (WISC-III foi utilizada para a avaliação neuropsicológica dos pacientes. Os resultados foram relacionados com a síndrome epiléptica, a etiologia da epilepsia, o tratamento medicamentoso, a idade do paciente no início da epilepsia e a duração da epilepsia. RESULTADOS: Os escores da WISC foram significativamente melhores no grupo controlado com medicação quando comparados aos do grupo não controlado com medicação. O grupo controlado com medicação obteve um desempenho significativamente melhor na maioria dos subtestes da WISC quando comparado ao grupo não controlado com medicação: vocabulário, aritmética, compreensão, memória de dígitos, completar figuras, arranjo de figuras e cubos. Um número significativamente maior de pacientes com epilepsia idiopática e uso de monoterapia foi observado no grupo controlado com medicação quando comparado ao grupo não controlado. O grupo controlado com cirurgia não apresentou diferença significativa no desempenho do QI quando comparado ao grupo controlado com medicação. CONCLUSÕES: As crianças com um bom controle de crises tiveram um melhor desempenho no QI geral, verbal e de execução quando comparadas às crianças com epilepsia refratária. Esses resultados podem ser influenciados por fatores clínicos como o uso de monoterapia, o tipo de droga antiepiléptica utilizada, a síndrome epiléptica e a etiologia da epilepsia. A cirurgia de epilepsia pode causar um impacto positivo no desempenho cognitivo das crianças que ficaram livres de crises após o procedimento cirúrgico.OBJECTIVE: To

  3. FROM THE CHINESE PRESS

    Institute of Scientific and Technical Information of China (English)

    1998-01-01

    Equality and harmony are mainstream in Chinese marriage. The conclusion was made by a systematic investigation in 1996 on love and marriage relations between couples in Shanghai, Harbin, Guangdong, Gansu and other regions. Six thousand couples were surveyed in a multi-period, separated level probability sampling; the research was conducted by the study group, "Marriage quality during the period of Chinese social

  4. About Chinese Characters

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The Chinese pictographs for 土 tǔ (earth) are "(?)", "(?)" and "(?)", reflecting the Chinese people of remote antiquity’s understanding of earth. They divided it into two layers, upper and subterranean, and used the "二" in "土" to represent both layers, the central "(?)" representing the plants that

  5. Not Your Father's Chinese

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    The government's first annual report on the evolution of the Chinese language contains some surprisesThe Chinese people are proud of their language, which they consider the most essential part of their civilization of 5,000 years. The charm of the language includes its ideographic writing system, in which the structure of the characters is directly related

  6. Danish-accented Chinese

    DEFF Research Database (Denmark)

    Wang, Lei; Sloos, Marjoleine 莱娜; Zhang, Chun

    In search for a linguistic basis for the education of Chinese as a foreign language CFL in Denmark, we set up a new line of investigation into CFL. This research focuses on the phonetics and phonology of Mandarin Chinese as compared to Danish. Considering the sound systems of both languages, we...

  7. Predicate Movements in Chinese

    Science.gov (United States)

    Shou-hsin, Teng

    1975-01-01

    The movements of such higher predicates as time, locative, and complementation verbs are studied, and Tai's Predicate Placement Constraint is rejected as an incorrect account of predicate movements in Chinese. It is proposed, on the other hand, that there is only leftward movement involving predicates in Chinese. (Author)

  8. Why I Learn Chinese

    Institute of Scientific and Technical Information of China (English)

    Keltoum; Otamani

    2013-01-01

    <正>I am eighteen years old. I have learned Chinese at the FFCA NordPas-de Calais for three years. I will continue to study Chinese during my five-year university life and try to get a job dealing with China in the future. I became interested in China at the age of 13, and my interest grew year by year.

  9. Doorway to Chinese Civilization

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Xi’an,the ancient Chinese capital and modern day metropolis,offers an exciting array of historic attractions and tourist charms The long and extensive history of Xi’an,an ancient Chinese capital,has endowed it with an abundant variety of cultural sites and artifacts,including the

  10. Chinese Conversation Structure

    Institute of Scientific and Technical Information of China (English)

    LIU Yan

    2016-01-01

    This paper aims to describe the features of Chinese conversation structure. Specifically speaking, the structure will be analyzed from the following four aspects:openings and pre-sequence, adjacency pairs, pre-closing and closing. Generally speak-ing, Chinese conversation structure is similar to English conversation structure. But still a lot of differences are found due to cul-tural factors.

  11. Courting Chinese Investors

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Inviting Chinese business delegations. Participating in trade fairs in China.Building an industrial park for Chinese investors. Poland is doing all theseand more to attract investment from China, according to Krzysztof Szumski,Poland ’s Ambassador to Chi

  12. AfricaonChineseDream

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

    At the opening of the 2013 Understanding and Cooperation Dialogue held by the Chinese Association for International Understanding (CAFIU) on July 23 in Beijing, former President of the Federal Repub-lic of Nigeria Olusegun Obasanjo expounded on his understanding of the Chinese dream and its implications for Africa. The ful text of his thoughts follow.

  13. Chinese Children's Songs.

    Science.gov (United States)

    Kwok, Irene, Comp.

    Singing can be an enjoyable and effective way to motivate children to learn a second language. This booklet consists of contemporary and folk songs that are related to Chinese festivals, transportation, the family, seasons, Christmas and other topics. Each page gives the music to a song with the words in Chinese and in English. The songs are…

  14. Modern Chinese History Studies

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    Famous Foreign Scholars' Lecture Tours in China Around the May Fourth Movement and Changes in Chinese Intellectual Circles From 1919 to 1924, John Dewey and four other famous foreign scholars came to China on lecture tours. These tours were great cultural undertakings to spread Western learning to the East after the First World War. The lectures these schol- ars gave helped to deepen the thoughts of Chinese people, and at the same time encouraged the diversification and evolution of Chinese intellectual circles. Firstly, the lectures hastened the birth of a contemporary Chinese wave of reflection on mo- dernity, and provided a basis for the theoretical views and cultural appeals of Liang Qichao and other members of the socalled "Orient Culture Faction," thereby increasing the tension intrinsic to the development of the New Culture Movement and to the expansion of intellectual horizons in Chinese intellectual circles.

  15. Study on Translating Chinese into Chinese Sign Language

    Institute of Scientific and Technical Information of China (English)

    徐琳; 高文

    2000-01-01

    Sign language is a visual-gestural language mainly used by hearing impaired people to communicate with each other. Gesture and facial expression are important grammar parts of sign language. In this paper, a text-based transfor mation method of Chinese-Chinese sign language machine translation is proposed.Gesture and facial expression models are created. And a practical system is im plemented. The input of the system is Chinese text. The output of the system is "graphics person" who can gesticulate Chinese sign language accompanied by facial expression that corresponds to the Chinese text entered so as to realize automatic translation from Chinese text to Chinese sign language.

  16. The Danger of Chinese Exceptionalism

    DEFF Research Database (Denmark)

    Li, Xin

    2016-01-01

    In the movement of Chinese indigenous management research, a sort of ‘Chinese exceptionalism’ (as critiqued by Peng, 2005: 133) seems to have been emerging, namely, some Chinese scholars see Chinese culture, philosophy, and way of thinking are unique and cannot be accounted for by some...

  17. Research in Ancient Chinese Language

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    JIANG Ji-cheng, A Brief Study of Arabian-Chinese Diaphone in Huihui Prescription Abstract: Based on meterials of Arabian- Chinese diaphone in Huihui Prescription, this paper studies all Chinese phonetic initials and finals in Yuan dynasty, including 21 initials and 34 finals. Key Words: Huihui Prescription, Arabian- Chinese diaphone, transferred sound, International Phonetic Alphabet

  18. Performing "Chinese-ness" in Singkawang

    NARCIS (Netherlands)

    Ong, C.E.; Ormond, M.E.; Sulianti, Dian

    2017-01-01

    Through an examination of two festivals – Qing Ming and Cap Go Meh – in the town of Singkawang in Indonesian Borneo (Kalimantan), we show how Singkawang-bound Chinese Indonesian tourists and their Singkawang-based relatives produce a diasporic heritage network through ‘moorings’ generated by both tr

  19. Interações farmacológicas entre medicações clínicas e psiquiátricas Drug interactions among clinical and psychiatric drugs

    Directory of Open Access Journals (Sweden)

    Marco Antonio Marcolin

    2004-01-01

    Full Text Available INTRODUÇÃO/JUSTIFICATIVA: Estudos apontam as reações adversas graves (ADR como uma das seis causas de morte em pacientes hospitalizados nos EUA, sendo que das ADR, a mais freqüente inclui as Interações Medicamentosas (IM. MÉTODOS: foram cruzadas 20 medicações mais utilizadas em andares clínicos do Hospital Universitário São Lucas da PUCRS com 14 medicações mais utilizadas no Ambulatório de Depressão do HSL-PUCRS; pesquisou-se no Medline e Lilacs a partir de 1990. RESULTADOS: foram encontradas diversas IM com muitas das medicações estudadas, envolvendo freqüentemente o Sistema Citocromo P450. CONCLUSÕES: conclui-se que a atualização sobre as medicações utilizadas em nossa prática clínica vai muito além dos efeitos esperados e efeitos colaterais mais freqüentes.BACKGROUND/JUSTIFICATION: Studies point up the serious adverse reactions (ADR as one of the six main causes of death of hospitalized patients in the United States. The most frequent ADR include the drug interaction. METHODS: twenty most used medications were compared, in a certain period of time, at the clinical sector of São Lucas Universitary Hospital of PUC-RS, to the fourteen most used ones at the Ambulatório de Depressão (ADe of the same hospital. The research gathered information published since 1990 in Medline and Lilacs. RESULTS: several drug interactions were found among many of the studied medications, often involving the Cytochrome P450 System. CONCLUSION: the update of the medication on clinic use goes further than the expected results or the most frequent collateral effects.

  20. Vitalismo - Materia - Affermazione

    Directory of Open Access Journals (Sweden)

    Rosi Braidotti

    2015-12-01

    Full Text Available This paper (transcription of a lesson given in Bologna on October 21, 2014 is centred in the discussion of the recent book of Braidotti, The Posthuman. It touches the issues of digital 'second life', genetically modified food, advanced prosthetics, robotics and reproductive technologies as facets of our globally linked and technologically mediated societies. From the discussion of the model of Humanism, passing through the question “are women human?”, she poses several questions about the meaning of our specie, also examining several forms of violence and injus-­‐‑ tice of current societies.

  1. IPP (INNOVACIÓN EN PRODUCTOS Y PROCESOS PARA EL SECTOR DE LAS MATERIAS PRIMAS MINERALES Y ENERGÉTICAS

    Directory of Open Access Journals (Sweden)

    CORREA ESPINAL ALEXANDER

    2010-05-01

    Full Text Available Este articulo proscrita los resultados del proyecto ce Investigación IPP (Innovación ce Procesos y Productos que plantea un análisis profundo y sistémico de las cadenas productivas, basado en el estudio de la productividad y los procesos. Este proyecto se trabajo en 4 fases: Inteligencia, Experimentación. Innovación y Apropiación tecnológica. Estas etapas están dirigidas al mejoramiento continuo ce los procesos, de los productos ce la organización y de las interacciones entre los actores de la cadena productiva de las materias primas minerales y energéticas. En la fase de inteligencia, se estudiaron las características, las ecesidades. el mercado y el entorno de la cadena productiva que son el resultado del aprovechamiento de los recursos naturales y del ambiente En la segunda fase, se caracterizó la formulación, diseño c implantación ce prototipos de procesos y productos que emulen el comportamiento del proceso en un sistema real y sean amigables con el medio ambiente. Teniendo en cuenta las dos primeras fases, la tercera se caracterizó por la formulación y el diseño ce nuevos procesos y productos que mejoren la eficiencia y la productividad. En la última fase del proyecto, se planteó el servicio de apropiación tecnológica que busca transferir innovación y conocimiento de punta a la cadena. Finalmente el resultado ce IPP es la propuesta de un centro de innovación y tecnología en la Universidad Nacional de Colombia, que garantizará la apropiación y adecuación de las soluciones a las cadenas productivas, siendo una innovación para el sector de la minería, los materiales y la energía, y teniendo como principios, productos y procesos amigables con el ambiente.

  2. Modelo de jerarquización de zonas prioritarias de recepción de subvenciones en materia de turismo rural en Andalucia

    OpenAIRE

    Francisco Javier Blancas Peral; Guerrero Casas, Flor María

    2005-01-01

    El objetivo de este trabajo es establecer una jerarquía de actuación pública que determine las zonas prioritarias de recepción de subvenciones en materia de Turismo Rural en Andalucía. Para ello, presentamos un modelo de jerarquización zonal multicriterio que utiliza como procedimiento de ordenación el método PROMETHEE II. Una vez definidos los elementos del problema de decisión (objetivo global, criterios de decisión y alternativas) y determinados los pesos relativos otorgados por el ce...

  3. Tecnologías para el aprovechamiento del gas producido por la digestión anaeróbica de la materia orgánica

    OpenAIRE

    Hernández A., Luis Alfredo

    2011-01-01

    El aprovechamiento energético del gas metano, compuesto principal del biogás, subproducto gaseoso producido de la fermentación anaeróbica de la materia orgánica, en forma sólida o soluble, constituye un factor importante que complementa las bondades tenológicas para la implantación y desarrollo de sistemas de tratamiento de residuos orgánicos mediante la digestión anaeróbica. El presente artículo muestra las bondades técnicas y operativas en la implementación de tecnologías para el aprovecham...

  4. Integración de Jatropha curcas L. en agroecosistemas como materia prima para biodiesel en la región centro de Chiapas, México.

    OpenAIRE

    Solís Guzmán, Blanca Flor

    2012-01-01

    Jatropha curcas L. es una opción de importancia en Chiapas como materia prima para biodiesel y se han establecido alrededor de 10 mil hectáreas, aún con escasa información como cultivo. El objetivo de este trabajo fue determinar el potencial de integración de J. curcas en agroecosistemas de la Región Centro de Chiapas, México. Esta investigación se realizó en tres etapas de 2008 a 2011. Primero se determinaron áreas potenciales con el programa ArcView GIS Ver. 3.2®, en dos escenarios: 1) pend...

  5. Distribución espacial del contenido de materia orgánica de los suelos agrícolas de Zapopan, Jalisco

    OpenAIRE

    Daniel Ibarra Castillo; José Ariel Ruiz Corral; José Germán Flores Garnica; Diego R. González Eguiarte

    2007-01-01

    El objetivo de la presente investigación fue determinar la distribución espacial del contenido de materia orgánica (MO), variable asociada con la fertilidad en los suelos agrícolas, del municipio de Zapopan, Jalisco, México. Se realizaron muestreos georreferenciados de suelo, para su posterior análisis en laboratorio y determinación del contenido de MO. Los resultados del análisis se capturaron en una hoja de cálculo electrónica (Microsoft Excel) para integrar una base de datos georreferenc...

  6. Caracterización estructural de la materia orgánica de tres suelos provenientes del municipio de aquitania boyacá, colombia

    OpenAIRE

    Mosquera, Carmen S.; Martínez, María J.; Guerrero, Jairo A.; Hansen, Eddy W.

    2010-01-01

    La materia orgánica del suelo puede variar considerablemente en su estructura, composición y conformación, de acuerdo con el origen y la edad de los materiales que la constituyen. En la presente investigación se procedió a caracterizar, mediante el empleo de la espectroscopia infrarroja y la resonancia magnética nuclear en estado sólido, dos suelos inceptisoles (I01 y I02) y un histosol (H03) destinados al cultivo de cebolla larga, en el municipio de Aquitania-Boyacá, Colombia, a dos profundi...

  7. La distancia entre la legislación vigente en materia de violencia de género y su aplicación

    OpenAIRE

    Moreno Cuerva, Luisa Pilar

    2016-01-01

    En la presente tesis se aborda el fenómeno de la violencia de género desde una perspectiva psicosocial y jurídica, con la intención de dejar constancia de la distancia que existe entre la legalidad vigente en materia de violencia de género y su aplicación. Con esta finalidad: Se analiza el tratamiento que ha dado el derecho a esta problemática social en el ámbito internacional, en España y en la Comunidad Autónoma de Cataluña. Se revisan las reformas penales introducidas en Espa...

  8. Recuperación de materias primas secundarias procedentes de residuos de aparatos eléctricos y electrónicos (RAEES)

    OpenAIRE

    Giménez San Andrés, Gerard

    2016-01-01

    Estudiar la viabilidad técnica y económica de la recuperación de materias primas secundarias, procedentes de los residuos de aparatos eléctricos y electrónicos. Para ello el proyecto se centrara en unos determinados tipos de RAEES y en la recuperación de ciertos materiales empleando unas tecnologías determinadas. Algunos de los factores que se tendrán en cuenta para realizar el análisis técnico y económico son el grado de recuperación, los recursos necesarios para lograrlo y la diferencia de ...

  9. Estudio del rendimiento académico en la asignatura Economía de la empresa a partir de los resultados obtenidos en otras materias

    OpenAIRE

    Etchart Iparraguirre, Leire

    2012-01-01

    Según las palabras del economista John Maynard Keynes, “el economista debe poseer una rara combinación de dotes. Debe ser, de algún modo, matemático, historiador, estadista y filósofo”. Haciéndose eco de estas palabras, en este trabajo, se pretende estudiar el rendimiento académico en la asignatura Economía de la Empresa, así como en cada una de las áreas en las que se divide, a partir de los resultados obtenidos en otras materias como Historia, Filosofía, Matemáticas, Idiomas,...

  10. Tratamiento de aguas residuales urbanas para la eliminación de nitrógeno y materia orgánica mediante un sistema SBR.

    OpenAIRE

    Pelaz Pérez, Lara

    2013-01-01

    La eliminación biológica de nitrógeno en aguas residuales, a partir de reactores discontinuos secuenciales o SBR (Sequencing Batch Reactors) es un proceso que da buenos resultados. Este trabajo muestra los resultados experimentales del proceso de tratamiento de un agua residual urbana de elevado contenido en nitrógeno amoniacal y baja materia orgánica fácilmente biodegradable. Toda la experimentación tuvo una duración de 355 días. Se ha optimizado la duración de cada ciclo ...

  11. Simulación de un sistema de fangos activados en discontinuo para la eliminación de materia orgánica y nutrientes

    OpenAIRE

    José Manga; Germán Escaf; Nury Logreira; Jaime García

    2003-01-01

    Se ha desarrollado un simulador para el sistema de fangos activados en discontinuo (Sequencing Batch Reactor o SBR), que permite el estudio de los procesos para la eliminación de la materia orgánica y nutrientes. El simulador incluye el modelo Nº 2d de fangos activados (ASM2d) propuesto por la International Water Association (IWA). Además, en fase de sedimentación, se incluye un modelo exponencial o de Vesinlind para la separación de los sólidos en suspensión del licor mezcla. ...

  12. Principales retos de la negociación de un tratado de libre comercio con Estados Unidos: Disciplinas en materia de inversión

    OpenAIRE

    Sergio Gómez Lora; Jaime Zabludovsky

    2005-01-01

    El Tratado de Libre Comercio de América del Norte (TLCAN) incluyó, por primera ocasión en un tratado de libre comercio (TLC), disciplinas de amplio alcance en materia de inversión, además de un mecanismo a través del cual un inversionista puede demandar a un Estado por violación del nivel de protección previsto en el acuerdo. El tema es una alta prioridad en la agenda estadounidense de negociaciones comerciales internacionales y ha sido incorporado en los tratados de libre comercio que este p...

  13. EFICIENCIA DE REMOCION DE MATERIA ORGÁNICA DE AGUAS RESIDUALES PORCINAS CON BIODIGESTORES EN EL ESTADO DE YUCATÁN, MEXICO

    OpenAIRE

    W. Trejo Lizama; L. B. Vázquez González; A. J Uicab; J. Castillo Caamal; A. Caamal Maldonado; R. Belmar Casso; R. Santos Ricalde

    2014-01-01

    En la crianza intensiva de cerdos en el estado de Yucatán, se establecieron 62 biodigestores en los últimos 10 años. Sin embargo la complejidad del proceso de biodigestión anaerobia conlleva dificultades para alcanzar la eficiencia esperada. El objetivo del presente trabajo fue determinar la eficiencia de remoción de materia orgánica de aguas residuales porcinas con biodigestores en el estado de Yucatán. Se visitaron 15 granjas porcinas en el estado de Yucatán, entrevistando al productor sobr...

  14. Morfología, Estructura y Función de Órganos y Sistemas del Cuerpo Humano: el reto de integrar materias y profesorado

    OpenAIRE

    2012-01-01

    En el grado de medicina de la UEM desde hace tres años se está llevando a cabo un modelo de docencia integrada que engloba las materias de Anatomía II, Histología II y Fisiología II. Los objetivos son impartir una docencia que integre los aspectos morfológicos y funcionales del cuerpo humano por sistemas con un enfoque orientado a la clínica, homogeneizar los criterios de evaluación y la metodología docente entre el profesorado, diseñar un temario que agrupe los aspectos esenciales de los con...

  15. "Autoridad responsable. Legitimación para interponer el recurso de revisión en el amparo indirecto en materia civil y mercantil."

    OpenAIRE

    Medina Treviño, Susana

    2011-01-01

    Hoy por hoy en el campo del derecho ha tomado auge la búsqueda, el análisis y la reflexión del conocimiento. Por ello, los furistas no hemos enfrentado al esclarecimiento de la premisa: Debido a la falibilidad de los fallos y la imposibilidad de la autoridad responsable para interponer el recurso de revisión en el amparo indirecto en materia civil y mercantil, realmente la principal finalidad del juicio de amparo es la Constitucionalidad de los actos de autoridad. Esto es, verdaderamente habl...

  16. LA EDUCACIÓN AMBIENTAL EN EL BACHILLERATO: EL CASO DE LOS DOCENTES QUE IMPARTEN LA MATERIA DE ECOLOGÍA, PUEBLA-TLAXCALA (MÉXICO

    Directory of Open Access Journals (Sweden)

    Adelina Espejel Rodríguez

    2012-01-01

    Full Text Available Los diferentes problemas que ocurren en el medio educativo han sido abordados desde diversos enfoques de análisis. Esta diversidad disciplinaria se deriva de la complejidad de situaciones estudiadas y es resultado de la dificultad en la definición de "lo educativo" como un campo metodológico y teórico (Bertely, 2004. Una de estas situaciones complejas es la Educación Ambiental (EA, que atañe a esta investigación. El objetivo de este artículo es conocer los alcances y las limitaciones de la práctica de la EA para promover y construir una conciencia ambiental entre alumnos del Bachillerato, así como, estimular iniciativas proambientales. La aproximación metodológica adoptada es la Etnografía Institucional (EI aplicada a la Educación Ambiental, la cual permitirá por un lado retratar la realidad lo más fidedigna posible, y por otro lado, adoptar este retrato a otras situaciones que ocurren en contextos institucionales similares. Entre los resultados encontramos que: (a los docentes no tienen el perfil deseable para enseñar el curso de Ecología y ellos no tienen los conocimientos ambientales básicos; (b el programa de estudios en la materia de Ecología ha sido creado de manera superficial y muy general; (c el curso de Ecología es nominal y (d la materia de Ecología es impartida en periodos de tiempo cortos y regida por una modalidad preferentemente teórica que práctica. En general, las limitaciones formativas de los docentes y las debilidades de los contenidos programáticos de la materia restringen abordar con interés y dimensionar la problemática ambiental. En consecuencia, se genera en el alumnado una formación sin actitudes y valores ambientales. El profesorado fracasa en su intención de lograr generar estudiantes con conciencia ambiental, propósito central de la materia de Ecología.

  17. Diseño de la bodega de materia prima del área de calzado en una industria plástica

    OpenAIRE

    Moreno, Paulina; Abad Morán, Jorge Fernando

    2009-01-01

    La presente tesis se enfoca dentro de la Bodega de Materia Prima del Área de Calzado en una Industria Plástica, la cual presenta problemas como: pasillos no identificados, todos los productos no están codificados, mezcla de productos de alta y baja rotación, stock de productos obsoletos, productos almacenados en otras áreas, no tiene un sistema de manejo y manipuleo. El objetivo principal es organizar los materiales en la bodega, minimizando los tiempos muertos y reduciendo la congestión en ...

  18. Evolución histórica y perspectivas actuales en las relaciones hispano-marroquíes en materia de pesca

    OpenAIRE

    2010-01-01

    La pesca ha constituido tradicionalmente uno de los apartados más relevantes en las relaciones comerciales hispano-marroquíes. Dichas relaciones se han venido materializando en sendos acuerdos de cooperación en materia de pesca cuyos condicionantes han evolucionado desde una clara posición de dominio por parte de España en los primeros acuerdos hacia una situación actual en la que la complejidad a la hora de satisfacer las demandas del reino de Marruecos hace inviable la consecución futura de...

  19. Modificación legislativa en materia de seguros en la República de Cuba. Comentarios al Decreto-Ley 263

    OpenAIRE

    Vigil Iduate, Alejandro; Universidad de La Habana

    2009-01-01

    Recién firmado el Decreto-Ley 263, del Contrato de Seguro, el que realiza una modificación sustancial en la legislación cubana al derogar lo establecido en la materia, en el Código Civil y Código de Comercio, y recoge los principios fundamentales del seguro, adecuando la legislación a las nuevas condiciones existentes en la República de Cuba, atemperada a las nuevas concepciones y corrientes doctrinales que refuerzan la función social del seguro. Se impone una primera aproximación a la normat...

  20. Referencias al aparato digestivo en los textos de materia médica impresos en España durante el Renacimiento y recuperados en bibliotecas digitales.

    OpenAIRE

    León Molina, Joaquín

    2013-01-01

    La tesis pretende identificar referencias al aparato digestivo en textos de materia médica impresos en España durante el Renacimiento. Describe el marco histórico, incluyendo la medicina de la época. Partiendo de la bibliografía se identifican autores y textos impresos en los albores de la imprenta y se intenta recuperar en bibliotecas digitales. Se estima, a priori, que al menos el 75% de los textos identificados deberían poder ser recuperados en la Red Informática Mundial y que al menos el ...

  1. Descripción y análisis de las reescrituras y versiones de la materia cidiana al servicio de la mediación lectora

    OpenAIRE

    Aldo Daparte Jorge

    2013-01-01

    La proliferación de una «literatura en segundo grado» (Genette) en los siglos XX y XXI es una prueba inequívoca del relieve que han adquirido factores del sistema literario distintos del producto, de manera singular el mercado, el consumidor y las interferencias con otros sistemas. Tomando como ejemplo la materia cidiana, en general, y el Cantar de Mio Cid, en particular, se aplican los instrumentos de análisis sobre la intertextualidad y la paratextualidad propuestos por Genette, complementa...

  2. Cultural Characteristics of Chinese Cuisine:From Contrastive Studies of English and Chinese

    Institute of Scientific and Technical Information of China (English)

    乞聪妮

    2014-01-01

    Chinese cuisine plays an important role in Chinese culture. The paper illustrates the features of Chinese cuisine in Chi-nese dish naming from different perspectives, and analyze them from contrastive studies of English and Chinese.

  3. Chinese remainder codes

    Institute of Scientific and Technical Information of China (English)

    ZHANG Aili; LIU Xiufeng

    2006-01-01

    Chinese remainder codes are constructed by applying weak block designs and the Chinese remainder theorem of ring theory.The new type of linear codes take the congruence class in the congruence class ring R/I1 ∩ I2 ∩…∩ In for the information bit,embed R/Ji into R/I1 ∩ I2 ∩…∩ In,and assign the cosets of R/Ji as the subring of R/I1 ∩ I2 ∩…∩ In and the cosets of R/Ji in R/I1 ∩ I2 ∩…∩ In as check lines.Many code classes exist in the Chinese remainder codes that have high code rates.Chinese remainder codes are the essential generalization of Sun Zi codes.

  4. Chinese Remainder Codes

    Institute of Scientific and Technical Information of China (English)

    张爱丽; 刘秀峰; 靳蕃

    2004-01-01

    Chinese Remainder Codes are constructed by applying weak block designs and Chinese Remainder Theorem of ring theory. The new type of linear codes take the congruence class in the congruence class ring R/I1∩I2∩…∩In for the information bit, embed R/Ji into R/I1∩I2∩…∩In, and asssign the cosets of R/Ji as the subring of R/I1∩I2∩…∩In and the cosets of R/Ji in R/I1∩I2∩…∩In as check lines. There exist many code classes in Chinese Remainder Codes, which have high code rates. Chinese Remainder Codes are the essential generalization of Sun Zi Codes.

  5. Chinese implicit leadership theory.

    Science.gov (United States)

    Ling, W; Chia, R C; Fang, L

    2000-12-01

    In a 1st attempt to identify an implicit theory of leadership among Chinese people, the authors developed the Chinese Implicit Leadership Scale (CILS) in Study 1. In Study 2, they administered the CILS to 622 Chinese participants from 5 occupation groups, to explore differences in perceptions of leadership. Factor analysis yielded 4 factors of leadership: Personal Morality, Goal Efficiency, Interpersonal Competence, and Versatility. Social groups differing in age, gender, education level, and occupation rated these factors. Results showed no significant gender differences, and the underlying cause for social group differences was education level. All groups gave the highest ratings to Interpersonal Competence, reflecting the enormous importance of this factor, which is consistent with Chinese collectivist values.

  6. Ancient Chinese Dress

    Institute of Scientific and Technical Information of China (English)

    1992-01-01

    Chinese archaeologists discov- ered in Zhoukoudian on theoutskirts of Beijing the firstneedle made by Chinese about 18,000years ago.It was about 82 mm longand 3.3 mm in diameter,polishedcarefully and had a hole,showing thatthe Chinese of that time had masteredthe skill of polishing and drilling andcould make clothes ont of animalskins.It Is recorded in The Book of Rites(one of the Confucian classics,includ- ing essays on rites and etiquette of theQin and Han dynasties),compiled byDai Sheng of the Western Han Dy- nasty(206 B.C.-A.D.24),that therehad been no flax or silk in the pastand people wore animal skins or feathers as clothes.That proves that appa-rel appeared earlier than textiles in theChinese culture.

  7. CHINESE OF HUMANITY

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    The feature and development direction of ecological garden city; The problem and countermeasures in urban construction audio-visual file management task;Youth network moral education is imperative;A shallow discussion about moral education penetration in Chinese classroom;

  8. Chinese Female Creativity

    Institute of Scientific and Technical Information of China (English)

    VALERIE; SARTOR

    2011-01-01

    "Many foreigners mistakenly believe that Chinese women are creatively oppressed,that they have been oppressed for centuries," Teacher Yang said,glancing at me wryly."That’s correct," I replied, lifting my eyebrows.

  9. FROM THE CHINESE PRESS

    Institute of Scientific and Technical Information of China (English)

    1994-01-01

    Compiled by the Central Document Compiling Committee of the Chinese Communist Party (CPC), the third volume of the Selected Works of Deng Xiaoping was published by the People’s Publishing House and was issued nationwide on November 2, 1993.

  10. The Chinese Olympic Committee

    Institute of Scientific and Technical Information of China (English)

    余信波

    2008-01-01

    The Chinese Olympic Committee (COC) is a non-governmental,non-profit national sports organization of a mass character,with the objective of developing sports and promoting the Olympic Movement in the country.

  11. Ancient Chinese Architecture

    Institute of Scientific and Technical Information of China (English)

    1993-01-01

    CHINESE people have accu-mulated a great deal ofexperience in architecture,constantly improving building ma-terials and thus creating uniquebuilding styles.The history of ancient Chinesearchitechtural development can be

  12. Expats rank Chinese cities

    Institute of Scientific and Technical Information of China (English)

    By Lv Dong

    2012-01-01

    Beijing, April The results of the "2011 Amazing China- The Most Attractive Chinese Cities for Foreigners" election are released. Expats choose Beijing, Shanghai, Tianjin and other cities as Chinas 10 most attractive cities for foreigners.

  13. Chinese Ecosystem Research Network

    Institute of Scientific and Technical Information of China (English)

    Huang Tieqing; Liu Jian; Chen Panqin; Fu Bojie

    2002-01-01

    The article analyzes the development of the Chinese Ecosystem Research Network, and its mission, mandate, and management mechanisms, with examples of research, demonstration and consultation for policy-setting.

  14. Traditional Chinese Biotechnology

    Science.gov (United States)

    Xu, Yan; Wang, Dong; Fan, Wen Lai; Mu, Xiao Qing; Chen, Jian

    The earliest industrial biotechnology originated in ancient China and developed into a vibrant industry in traditional Chinese liquor, rice wine, soy sauce, and vinegar. It is now a significant component of the Chinese economy valued annually at about 150 billion RMB. Although the production methods had existed and remained basically unchanged for centuries, modern developments in biotechnology and related fields in the last decades have greatly impacted on these industries and led to numerous technological innovations. In this chapter, the main biochemical processes and related technological innovations in traditional Chinese biotechnology are illustrated with recent advances in functional microbiology, microbial ecology, solid-state fermentation, enzymology, chemistry of impact flavor compounds, and improvements made to relevant traditional industrial facilities. Recent biotechnological advances in making Chinese liquor, rice wine, soy sauce, and vinegar are reviewed.

  15. The Chinese Politeness Scale

    Institute of Scientific and Technical Information of China (English)

    王喜凤

    2012-01-01

    In order to make sense of what is said in an interaction,we have to look at various factors which relate to social distance and closeness.Generally,these factors include the specific situation language takes place,the relative status of the two participants,the message being delivered and finally the age of the participants.In this article,the Chinese Politeness Scale,based on Chinese social values and tradition,will be explained and demonstrated in detail.

  16. Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    2009013 Clinical observation on treatment of active rheumatoid arthritis with Chinese herbal medicine. SHENG Zhenghe(盛正和), et al.Dept TCM, 5th Affili Hosp, Guangxi Med Univ, Guangxi 545001. Chin J Integr Tradit West Med 2008;28(11):990-993. Objective To study the efficacy and safety of Chinese drugs for expelling evil-wind, removing dampness, promoting blood circulation and invigorating yin in treating active rheumatoid arthritis (RA).

  17. The Magic of Chinese

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    One of the world's oldest languages appears to have a vibrant futureClassical Greek and Latin, two languages that share an ancient history with Chinese, have been threatened with extinction, being used primarily in classic books or for special purposes. Chinese, on the other hand, is thriving as more and more people develop an interest in learning the language, and its charm has been noticed by linguists.

  18. Chinese New Year

    Institute of Scientific and Technical Information of China (English)

    王芳

    2005-01-01

    The Chinese New Year is now known as the Spnng Festival because it starts trom the beginning otspring. Though there are some sayings about its origin (起源), all agree that the word Nian, which inmodern Chinese means “year”, was originally the name of a beast (野兽) that started to eat people thenight before the beginning of a new year.

  19. Clinical Study on Treatment of Infantile Rotaviral Enteritis with Guava Leaf

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    [1]Thillainayagam AV, Dias JA, Salim AFM, et al. Glucose polymer in the fluid therapy of acute diarrhea: studies in a model of rotavirus infection in neonatal rats. Clin Sci 1994;86∶460-477.[2]Haffejec IE. The epidemiology of rotavirus infections: A global perspective. J Pediatric Gastroenterology and Nutrition 1995;20∶275-286.[3]WEI LB, LU RH, CHEN BT. The effect of guava leaf in antagonizing rotavirus in vitro. World Chinese J Digestion 1999;7(1)∶895-897.[4]Ministry of Health of PRC. Guidance on Principle of Clinical Research of Chinese New Drugs. 1st ed. Beijing: 1993,126-128, 227-229.[5]LI JL, LU JB, CHEN FL. Thin layer scanning of guaijaverin in guava leaf. J Chinese Materia Medica 1999,24(suppl)∶24-25.[6]LI JL, LU JB, CHEN FL. Analysis of volatile oil in gauva leaf by GC-MS. J Chinese Materia Medica 1999;22(2)∶79-80.[7]Paul A. Host factor associated with protection against rotavirus disease: The skies are clearing. J of Infectious Dis 1996;174(suppl)∶59-64.

  20. Alternativas de medicação intracanal em casos de necrose pulpar com lesão periapical = Intracanal medication indicated for pulpal necrosis with apical osteites

    Directory of Open Access Journals (Sweden)

    Fachin, Elaine Vianna Freitas

    2006-01-01

    Full Text Available Trata-se de estudo in vivo em pacientes portadores de dentes monorradiculares apresentando necrose pulpar com lesão periapical. O objetivo foi avaliar radiograficamente a efetividade de 4 diferentes curativos de demora (PMCC, gel de clorexidina 2%, pasta de hidróxido de cálcio e hipoclorito de sódio1%. O tratamento endodôntico foi padronizado em todos os elementos através da técnica escalonada e irrigação com hipoclorito de sódio 1%. Para a medicação intracanal, os pacientes foram separados aleatoriamente em 4 grupos que receberam um dos medicamentos listados. Após 7 dias, os canais foram obturados e submetidos a controle radiográfico aos 3, 6 e 9 meses em que se mediu com precisão a diminuição do diâmetro radiolúcido apical. Os resultados mais satisfatórios ocorreram após o uso do PMCC, seguido pelo hidróxido de cálcio, clorexidina 2% e, por último, hipoclorito de sódio 1%

  1. Insights into the history of a bacterial group II intron remnant from the genomes of the nitrogen-fixing symbionts Sinorhizobium meliloti and Sinorhizobium medicae.

    Science.gov (United States)

    Toro, N; Martínez-Rodríguez, L; Martínez-Abarca, F

    2014-10-01

    Group II introns are self-splicing catalytic RNAs that act as mobile retroelements. In bacteria, they are thought to be tolerated to some extent because they self-splice and home preferentially to sites outside of functional genes, generally within intergenic regions or in other mobile genetic elements, by mechanisms including the divergence of DNA target specificity to prevent target site saturation. RmInt1 is a mobile group II intron that is widespread in natural populations of Sinorhizobium meliloti and was first described in the GR4 strain. Like other bacterial group II introns, RmInt1 tends to evolve toward an inactive form by fragmentation, with loss of the 3' terminus. We identified genomic evidence of a fragmented intron closely related to RmInt1 buried in the genome of the extant S. meliloti/S. medicae species. By studying this intron, we obtained evidence for the occurrence of intron insertion before the divergence of ancient rhizobial species. This fragmented group II intron has thus existed for a long time and has provided sequence variation, on which selection can act, contributing to diverse genetic rearrangements, and to generate pan-genome divergence after strain differentiation. The data presented here suggest that fragmented group II introns within intergenic regions closed to functionally important neighboring genes may have been microevolutionary forces driving adaptive evolution of these rhizobial species.

  2. Chemical composition and bioactivity of Citrus medica L. cv. Diamante essential oil obtained by hydrodistillation, cold-pressing and supercritical carbon dioxide extraction.

    Science.gov (United States)

    Menichini, Federica; Tundis, Rosa; Bonesi, Marco; de Cindio, Bruno; Loizzo, Monica R; Conforti, Filomena; Statti, Giancarlo A; Menabeni, Roberta; Bettini, Ruggero; Menichini, Francesco

    2011-04-01

    The chemical composition of the essential oil of Citrus medica L. cv. Diamante peel obtained by hydrodistillation, cold-pressing and supercritical carbon dioxide extraction techniques was determined by GC/MS analysis. Forty-six components were fully characterised. Limonene and γ-terpinene were the major components of the oils obtained by hydrodistillation (HD) and cold-pressing (CP), while citropten was the major constituent in the oil obtained by supercritical carbon dioxide extraction (SFE). Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities were evaluated. The essential oil obtained by hydrodistillation exerted the highest inhibitory activity against BChE (IC₅₀ value of 154.6 µg mL⁻¹) and AChE (IC₅₀ value of 171.3 µg mL⁻¹. Interestingly, the oil obtained by cold-pressing exhibited a selective inhibitory activity against AChE. The essential oils have also been evaluated for the inhibition of NO production in LPS induced RAW 264.7 macrophages. The oil obtained by hydrodistillation exerted a significant inhibition of NO production with an IC₅₀ value of 17 µg mL⁻¹ (IC₅₀ of positive control 53 µg mL⁻¹).

  3. Erros de medicação: estudo descritivo das classes dos medicamentos e medicamentos de alta vigilância

    Directory of Open Access Journals (Sweden)

    Elena Bohomol

    2014-04-01

    Full Text Available Este estudo objetivou apresentar as classes dos medicamentos envolvidos nos erros de medicação ocorridos em Unidade de Terapia Intensiva e identificar aqueles que são classificados como medicamentos de alta vigilância. Métodos: A população foi composta pelas fichas de ocorrências de erros que constavam em um banco de dados de uma investigação prévia. Foi realizada uma análise secundária das informações disponíveis Resultados: Foram identificados 305 eventos, obtendo-se média de 6,9 ocorrências por paciente. Verificaram-se 73 medicamentos distribuídos em 33 classes de acordo com sua ação predominante, sendo os mais frequentes: antibióticos (25,2%, redutores de acidez gástrica (19,0% e anti-hipertensivos (9,2%. Foram identificadas 37 (12,1% ocorrências com medicamentos de alta vigilância, que corresponderam às cinco classes, e a dos anestésicos venosos foi predominante (43,3%. Conclusão: Estes tipos de medicamentos são usados frequentemente nas unidades intensivas e devem ter um monitoramento acurado, uma vez que podem causar danos maiores se o seu uso for incorreto.

  4. Secretory Cavity Development and Its Relationship with the Accumulation of Essential Oil in Fruits of Citrus medica L. var. sarcodactylis (Noot.) Swingle

    Institute of Scientific and Technical Information of China (English)

    She-Jian Liang; Hong Wu; Xuan Lun; Dong-Wen Lu

    2006-01-01

    The developmental types of secretory cavities in Citrus remain controversial. The relationship between secretory cavity development and the accumulation of essential oil in fruits of Citrus species is also unknown. In order to develop better insights into these problems, histological, histochemical, and cytochemical methods were used to investigate secretory cavity development and the accumulation of essential oil at different developmental stages of fruits of Citrus medica L. var. sarcodactylis (Noot.) Swingle.The results indicate that the secretory cavity of the variety seemed to originate from an epidermal cell and a subepidermal cell. These two cells underwent successive divisions, resulting in the formation of two parts: (i) a conical cap; and (ii) a globular gland. The formation of the lumen was schizolysigenous. Regular changes in the size of vacuoles and the accumulation of essential oil were revealed during the process of secretory cavity development. In addition, when fruits were a light yellow or golden color, the structure of secretory cavities was well developed and the content of essential oil in a single fruit reached a maximum. It would be most appropriate to collect the fruit as a medicinal material at this time.

  5. Chinese Advertising and Advanced Chinese Culture

    Institute of Scientific and Technical Information of China (English)

    Liu Fan

    2006-01-01

    @@ Chinese advertising has long been inseparable from the Chinese national culture from late Shang Dynasty and early Zhou Dynasty when Jiang Ziya beat sword to spread sound to the 21st century when the badge of Beijing 2008 Olympic Games sweeps the whole world. With cultural trait as one of its fundamental character,advertising naturally becomes one of the most important cultural industries in contemporary era. In recent years because of prevalent theme, "Rediscover the Brilliance of Ancient Cities," promoted by the 39th IAA World Congress and the 12th China Advertising Festival held in China, Beijing and Xi'an, two ancient cities, had been splendidly presented to the whole world.

  6. El acceso por materias en los catálogos en línea: análisis comparativo de interfaces

    Directory of Open Access Journals (Sweden)

    Marcos, Mari Carmen

    2004-03-01

    Full Text Available An analysis of a sample of interfaces of OPACs is presented, particularly those aspects that concern the search that more difficulties raises: the access by subjects. The chosen sample includes twenty catalogues of university libraries of Spain and Latin America in Spanish and with different systems. The studied points are the subject access from the first screen of the catalogue, the search process, the presentation of the set of results obtained, the information given on each recovered document and the reformulation of the search. Screen captures are shown as a representative example of the different aspects analyzed.

    Se presenta un análisis de una muestra de interfaces de OPACs, concretamente se atiende a los aspectos que atañen a la búsqueda que más dificultades plantea: el acceso por materias. La muestra elegida comprende veinte catálogos de bibliotecas universitarias de España y Latinoamérica en lengua española y con diferentes sistemas informáticos. Los puntos estudiados son el acceso por materias desde la pantalla de inicio del catálogo, el proceso de la consulta, la presentación del conjunto de resultados obtenido, la información que se da de cada documento recuperado y la reformulación de la consulta. Se acompañan capturas de pantalla como ejemplo representativo de los distintos aspectos analizados.

  7. La gestión de las materias primas silíceas en el Pirineo Occidental: la ocupación Magdaleniense de Berroberria (Urdax, Navarra

    Directory of Open Access Journals (Sweden)

    Irantzu ELORRIETA BAIGORRI, Antonio TARRIÑO VINAGRE

    2016-01-01

    Full Text Available La cueva de Berroberria es uno de los yacimientos más representativos del Magdaleniense en el Pirineo Occidental. Se presentan en este caso los resultados del estudio de procedencia de las materias primas líticas empleadas por los grupos del Magdaleniense Medio (alrededor de 14500 cal. BC. La metodología propuesta incluye análisis petrológicos y mineralógicos, mediante los que se identifican los principales afloramientos de sílex de los que se abastecieron. Se ha constatado así la explotación mayoritaria de los recursos silíceos más cercanos, como es el sílex de Flysch, junto con la de recursos regionales, como los sílex de Tercis o Chalosse, y siendo minoritarios pero de gran interés los aportes de materias primas extra-regionales de posible procedencia noraquitana. La gestión de cada una de estas rocas, al igual que su representación, es diferente; pero concuerda con la dinámica observada para esta cronología.

  8. EVALUACIÓN DE MATERIAS PRIMAS EN UNA PLANTA DE BENEFICIO DE ARENA DE SILICE PARA AUMENTAR LA EFICIENCIA ENERGÉTICA DEL PROCESO DE MOLIENDA

    Directory of Open Access Journals (Sweden)

    BEATRIZ ÁLVAREZ-RODRÍGUEZ

    2013-01-01

    Full Text Available El presente trabajo tiene por objetivo primordial optimizar el consumo energético y reducir la contaminación ambiental asociada, por la liberación de CO2, en una planta de micronización de sílice. La metodología empleada consiste en aplicar la teoría de Bond para la selección de materias primas a tratar en la mencionada planta, la cual dependiendo de las necesidades actuales opera con dos tamaños de molienda d100, 50 y 75μm. Los ensayos experimentales se llevaron a cabo sobre muestras tomadas en la planta, teniendo en cuenta que las tres materias primas son de distinta procedencia y de similares características químicas y mineralógicas. Del análisis de los resultados obtenidos se concluye que el consumo energético de la planta puede reducirse hasta algo más de un 30% en ambos tamaños y evitando las emisiones de CO2 en 293,83 kg y 128,86 kg por hora de funcionamiento respectivamente.

  9. Ahorro de agua y materia prima en los procesos de pelambre y curtido del cuero mediante precipitación y recirculación de aguas

    Directory of Open Access Journals (Sweden)

    SANDRA AGUDELO A.

    2007-01-01

    Full Text Available El principio del proceso de recuperación de cromo, consiste en precipitar el cromo contenido en el licor residual como hidróxido utilizando un álcali; este precipitado se separa por sedimentación y se disuelve nuevamente con ácido sulfúrico. De los resultados obtenidos, se observaron porcentajes de remoción superiores al 99%. Con la recirculación directa de aguas de pelambre fue posible obtener ahorros de agua del 64% y ahorros en materia prima del 32 %, además, con una adecuada selección del tamizador es posible recircular el agua un número máximo de tres veces, sin afectar la calidad del producto final. Así mismo, se comprobó la viabilidad de la recirculación directa de aguas de curtido, con ahorros de materia prima del 17%. Con medidas de este tipo, prácticas y fáciles de implementar, la industria del curtido del cuero podría disminuir considerablemente la contaminación, operar de una forma mas segura y con mayor eficiencia de producción.

  10. Imágenes del átomo: un producto del esfuerzo científico por comprender la estructura de la materia

    Directory of Open Access Journals (Sweden)

    P. Cabrera

    2009-10-01

    Full Text Available En este escrito mostramos algunas de las representaciones del constituyente básico de la materia, siendo todas creaciones del intelecto humano, y no por ello son cuentos de hadas, por el contrario se encuentran basados en valores numéricos y datos experimentales, avalados por teorías aceptadas, no obstante al estar ubicadas en diferentes momentos históricos, suplían solo las necesidades de la época. Así pues, haciendo una revisión del concepto, se abarca la idea de átomo desde las ultimas concepciones de la mecánica clásica, su transición en lo que se conoce como una mezcla entre la mecánica clásica y cuántica (mecánica cuántica de antaño, y la nueva representación que implico la visión de la mecánica cuántica, en adición a esto y haciendo alusión al título, mostraremos un nuevo constituyente básico de la materia desarrollado a través de la manipulación del hombre denominados puntos cuánticos.

  11. Una fuente potencial de conflictos jurídicos: la mala praxis en materia de incorporación de la normativa en el Mercosur

    Directory of Open Access Journals (Sweden)

    Alejandro Pastori

    2014-10-01

    Full Text Available Los comentarios que se desarrollan en este arÚculo, tienen por finalidad el planteo y análisis de la falta de certeza que existe en materia de vigencia de la normativa del Mercado Común del Sur (MERCOSUR, como consecuencia, esencialmente, de la mala praxis de los Estados en cumplir con las disposiciones en materia de incorporación de la normativa MERCOSUR. Esta circunstancia, que por cierto no beneficia al proceso de integración en su conjunto, se traduce en la posibilidad cierta de conflictos entre Estados o particulares, por lo que creemos de interés el estudio del tema.Aclaramos que no constituye objeto de este trabajo ahondar en el hecho comprobado de la omisión de los Estados Parte de proceder a la incorporación de las normas y en la necesidad de que activen sus procedimientos internos,a estos efectos, sino el analizar las consecuencias jurídicas de las eventuales desviaciones, por parte de éstos, en la aplicación de las disposiciones vinculadas al procedimiento de incorporación de las normas MERCOSUR. A este último aspecto únicamente es al que nos referimos entonces con la expresión "mala praxis". 

  12. UNAPAL –Abanico 75: nuevo cultivar de zapallo con alto contenido de materia seca en el fruto para fines agroindustriales

    Directory of Open Access Journals (Sweden)

    Estrada Salazar Edgar Iván

    2010-09-01

    Full Text Available A partir de tres cruzamientos dialélicos entre poblaciones de zapallo, con diferente grado de endocría (S0 x S0, (S1 x S1 y (S2 x S2, se seleccionaron dos híbridos y dos líneas de zapallo, por su alto contenido de materia seca en fruto y producción por planta. Con los genotipos seleccionados se formaron siete poblaciones híbridas, que se estabilizaron genéticamente mediante cruzamientos fraternales y se evaluaron en diferentes ambientes del Valle del Cauca. Se seleccionó la población 1, que presentó una producción por planta entre 29 - 32 kg; peso promedio del fruto entre 5 -6 kg.; 4 -5 frutos por planta; 24 -26% de materia seca en el fruto; formato globular acostillado de color externo verde intenso y color de pulpa amarillo intenso a naranja (12 a 15 abanico de Roche. Esta población fue registrada en el Instituto Colombiano Agropecuario ICA con el nombre de UNAPAL-Abanico-75.

  13. Cribado de microorganismos y materias primas para intensificar la producción de enzimas celulasas en fermentación en estado sólido

    Directory of Open Access Journals (Sweden)

    Gualberto León-Revelo

    2015-01-01

    Full Text Available En el presente trabajo, se llevó a cabo el cribado de hongos filamentosos y la evaluación de las principales materias primas del medio de cultivo para intensificar la producción de enzimas celulasas en Fermentación en Estado Sólido (FES. Entre los microorganismos estudiados, Aspergillus niger presenta la máxima expresión de enzimas celulasas extracelulares con fracción de halo de hidrólisis de 0,5 a las 24 horas. El estudio de concentración de inóculo y las materias primas mostró la mayor actividad, de 51,3 IU/gMs y productividad de 2,13 IU/gMs*h en el tiempo 24 horas, cuando se inocula una concentración de hifas de 28 g/kgMs, sulfato de amonio (0,14 % p/v y extracto de levadura (0,73 % p/v como fuente de nitrógeno inorgánico y orgánico, lactosa (5 g/L como fuente de carbono y afrecho cervecero como material lignocelulósico.

  14. Determinación de materia orgánica y hierro en rocas pizarrosas mediante medición de su coloración

    Directory of Open Access Journals (Sweden)

    Encinas, M.

    1990-08-01

    Full Text Available The study of several Palaeozoic shales has allowed to establish a definite correlation between organic matter, or iron content, and colour (as determined with a reflectometer. Hyperbolic curves obtained by plotting the data, show correlation coefficients above 0.9. Colour in rocks is inf!uenced by carbonate content whereas reflectivity is increased by it. Use of a reflectometer, or the Munsell chart of colours, is then proposed as an easy, fast and accurate enough method of estimating organic matter or iron content on this type of pelitic rocks.El análisis de diferentes pizarras paleozoicas ha permitido establecer una correlación positiva entre el contenido en materia orgánica, así como en hierro, y su coloración, medida con un reflectómetro. . Las curvas que mejor se ajustan a los datos obtenidos son las de tipo hiperbólico, con coeficientes de correlación superiores a 0,9. La presencia de carbonatos influye notablemente en el color de las rocas, aumentando los valores de reflectividad. Se propone la utilización de un reflectómetro, o de la carta de colores de Munsell, como un método fácil, rápido y bastante preciso para estimar el porcentaje de materia orgánica y de hierro en este tipo de rocas pelíticas.

  15. Effects of Shensong Yangxin capsule on pacemaker channels encoded by human HCN4 gene

    Institute of Scientific and Technical Information of China (English)

    SUN Li-ping; LI Ning; WU Yi-ling; PU Jie-lin

    2010-01-01

    @@ Shensong Yangxin (SSYX) is one of the compound recipes of Chinese materia medica including 12ingredients such as Panax ginseng, dwarf lilyturf tuber,nardostachys root, etc. Small-scale randomized multi-centre clinical trials suggested that SSYX reduced the number of ventricular extrasystoles in patients with or without structural heart disease.1 Besides excellent antiarrhythmic efficacy,2 SSYX also improved bradycardia in some patients, which was evidenced by animal studies3 as well. However, the antiarrhythmic mechanisms of SSYX have not been fully understood.Our previous studies have explored effect of SSYX on many channels except hyperpolarization-activated cation channel encoded by human hHCN4 gene.4

  16. HPLC Fingerprint and LC/MS/MS Identification of the Active Components in Radix Salviae Miltiorrhizae

    Institute of Scientific and Technical Information of China (English)

    HU,Ping; LIANG,Qiong-Lin; LUO,Guo-An; JIANG,Zhi-Hong

    2004-01-01

    @@ Radix Salviae Miltiorrhizae (丹参, RSM), an important Chinese Materia Medica, is widely used for cardiovascular diseases in China. Phenolic compounds[1] and diterpenoids[2] which are the major constituents of RSM have been reported to protect myocardium against ischemia-induced derangement, protect neural cells against injuries caused by anoxia,inhibit platelet aggregation, reduce hepatic fibrosis and depress the activities of HIV-1.[3] For the purposes of establishing quality standard of RSM and studying the relationship between the pharmacological activities and quantities of constituents, we conducted studies on HPLC fingerprint and LC-MS-MS identification of the active constituents of RSM.

  17. DEVELOPMENT OF ACUPUNCTURE TREATMENT AND CLINICAL RESEARCH OF THREATENED ABORTION

    Institute of Scientific and Technical Information of China (English)

    LI Jing-xia; XIE Gan-gong

    2005-01-01

    In the present paper, the authors review recent development of acupuncture treatment of threatened abortion from 1) clinical application of "Linggui Bafa"(灵龟八法Eight Methods of Intelligent Turtle), 2) body acupoints, and 3) acupuncture combined with Chinese materia medica, and clinical study from 1) effect of acupuncture on the blood flow of uterus, and 2) effect of acupuncture on plasma progesterone level. In addition, acupuncture therapy is also used to help women in gestation and can effectively raise the pregnant rate. "Linggui Bafa" is rather effective in preventing threatened abortion and should be studied further.

  18. Conocimiento previo y comprensión lectora en un texto de materia teológica

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    Méndez Anchía, Silvia

    2007-12-01

    Full Text Available Resumen: Estudio el libro Cristología, fe de Jesús, fe cristiana, de Francisco Avendaño Herrera (San José: UNED, 2002, para determinar cómo influyen los conocimientos previos del estudiantado (asociados con una perspectiva tradicionalista en su comprensión lectora del conocimiento nuevo que presenta el texto de Avendaño. Recolecté los datos mediante observación participante en las tutorías del curso de Cristología en que se utiliza el texto (programa de Teología a Distancia de la UNED y la UNA, ambas instituciones de educación superior de Costa Rica. Analizo los resultados con base en tres posibles formas de lectura: autoritaria, negociada y competente. Concluyo señalando un predominio de la lectura autoritaria y negociada, que puede explicarse por la función social de la religión en la construcción de la realidad de los sujetos, razón por la cual estos parecen resistirse a comprender un conocimiento nuevo que les genera incertidumbre en su visión de mundo en materia religiosa. Emito, finalmente, una serie de recomendaciones sobre cambios que, con base en los resultados de este estudio, podrían introducirse en una nueva edición del libro analizado.Abstract: I have studied Francisco Avendaño-Herrera’s book Cristología, fe de Jesús, fe cristiana («Christology, the faith of Jesus, the faith of Christendom» (San Jose: UNED, 2002 to determine how the students’ prior knowledge (associated with a traditionalistic outlook influences their reading comprehension of such new knowledge as could be acquired from Avendaño-Herrera’s book. I collected the data through observation while attending tutoring sessions at the Christology course where the text is used (under the distance education programme in theology of both, UNED and UNA, which are Costa Rican higher education institutions. I analysed the results based on the possibility to do an authoritarian, a negotiated, and a competent reading. In conclusion, may I point to a

  19. Aspectos a considerar en una actualización de la normativa nacional en materia de legionelosis

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    Eduardo Forján Lozano

    2016-03-01

    Full Text Available Objetivo: En España, el vigente Real Decreto 865/2003 establece una serie de medidas destinadas a la prevención de la legionelosis que inciden especialmente en el mantenimiento de las instalaciones de riesgo relacionadas con la proliferación y transmisión de Legionella. Este trabajo pretende revisar determinados aspectos estructurales, de mantenimiento, operacionales y documentales que, desde el punto de vista del Control Oficial, podrían ser incluidos en una futura nueva norma que pudiera ser más efectiva, si cabe, en la prevención y control de la legionelosis en las instalaciones de riesgo. Materiales y Métodos: Se ha utilizado la normativa nacional vigente en materia de la legionelosis, documentación técnica de apoyo, otras normativas de aplicación en países de la Unión Europea, así como servicios en línea de información científica (ISI Web of Knowledge y bases de datos de bibliografía médica (MEDLINE PubMed. Resultados y Discusión: Tras más de una década en vigor, es necesario que ciertos aspectos técnicos de las instalaciones de riesgo en la transmisión de la legionelosis sean revisados y adecuados al conocimiento actual y a la experiencia adquirida. Entre ellos se encuentran la clasificación de riesgo de las instalaciones, aspectos técnicos y operacionales de los sistemas de agua fría de consumo humano y caliente sanitaria, de los equipos de enfriamiento evaporativos, de los sistemas de agua climatizada y de los procedimientos de toma de muestras. Por último, se discute sobre la inclusión de técnicas analíticas basadas en la Biología Molecular (qPCR como método oficial en la determinación de Legionella. Conclusiones: Una posible nueva normativa sobre prevención y control de la legionelosis debe contemplar una clasificación de las instalaciones en función del riesgo, que recoja las de reciente aparición que han sido asociadas a brotes. También deberá contar con anexos sobre las medidas preventivas

  20. El Poder Judicial de la Federación como Actor Determinante en la Implementación de las Políticas Públicas en Materia de Competencia Económica en México

    OpenAIRE

    Ruiz García, José R.

    2016-01-01

    La presente investigación, titulada El Poder Judicial de la Federación como actor determinante en la implementación de las políticas públicas en materia de competencia económica en México, es resultado de considerar que existen muy pocos estudios que contemplan y analizan el papel determinante y preponderante que tiene el Poder Judicial de la Federación para reorientar y rediseñar por parte de los órganos reguladores, las diversas políticas públicas en materia de competencia económica que se ...