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Sample records for chinese male volunteers

  1. Effect of tamsulosin on the pharmacokinetics of dutasteride in Chinese male healthy volunteers.

    Science.gov (United States)

    Li, Huafang; Yang, Jiansong; Zhao, Hongxin; Fossler, Michael J; Wang, Chunrong

    2015-11-01

    The purpose of this study was to evaluate the effect of tamsulosin (0.2 mg) on the pharmacokinetics of dutasteride (0.5 mg) in a group of healthy Chinese male volunteers. This was an open-label, single-sequence, 3-period, drug-drug interaction phase 1 study. Twenty-four healthy Chinese male volunteers were enrolled and administered a single dose of 0.5 mg dutasteride and, following a 28- to 30-day washout period, 0.2 mg tamsulosin once daily for 7 days. On day 5, subjects received 0.2 mg tamsulosin coadministered with 0.5 mg dutasteride. Serum dutasteride and tamsulosin concentrations were monitored. In the presence or absence of tamsulosin, there were no apparent changes in dutasteride AUC and Cmax . Adverse events reported were mild to moderate in intensity and resolved by the end of the study. In healthy Chinese male volunteers, tamsulosin 0.2 mg at steady state had no apparent effect on dutasteride pharmacokinetics. Dutasteride and tamsulosin when administered alone or in combination were well tolerated.

  2. Pharmacokinetics and bioequivalence studies of galantamine hydrobromide dispersible tablet in healthy male Chinese volunteers.

    Science.gov (United States)

    Zhang, Li-jun; Fang, Xiao-ling; Li, Xue-ning; Wang, Qing-song; Han, Li-mei; Zhang, Zhi-wen; Sha, Xian-yi

    2007-03-01

    A randomized, two-way, crossover study was conducted in 18 healthy male Chinese volunteers to compare pharmacokinetics profiles of galantamine hydrobromide dispersible tablet with that of conventional tablet. A single oral dose of 10 mg galantamine was administrated to each volunteer. Plasma concentrations of galantamine were determined by a validated high-performance liquid chromatography (HPLC) method with fluorescence detection, which allowed 1 ng/mL to be assayed as the lowest quantifiable concentration. From plasma concentrations, AUC(0-->t) (the area under the plasma concentration-time curve from time 0 to the last sampling time, 32 hr), AUC(0-->infinity) (the area under the plasma concentration-time curve from time 0 to infinity), t((1/2)) (elimination of half-life of the terminal log linear phase), C(max) (maximum plasma drug concentration) and T(max) (time to reach C(max)) were evaluated through noncompartmental pharmacokinetic analysis. AUC(0-->t) and AUC(0-->infinity) were calculated by the linear-log trapezoidal rule method. C(max) and T(max) were obtained directly from the plasma concentration-time curve. Analysis of variance was carried out using logarithmically transformed AUC(0-->t), AUC(0-->infinity) and C(max). As far as AUC(0-->t), AUC(0-->infinity) and C(max) were concerned, there was no statistically significant difference between the test and reference formulations. Ninety percent confidence intervals (90% CI) for the ratio of AUC(0-->t), AUC(0-->infinity) and C(max) values for the test and reference formulations were 100.4-107.8%, 99.0-107.2% and 87.5-111.3%, respectively. As the 90% CIs of AUC(0-->t), AUC(0-->infinity) and C(max) were entirely within 80-125%, two formulations were considered bioequivalent.

  3. Effect of St. John's wort supplementation on the pharmacokinetics of bupropion in healthy male Chinese volunteers.

    Science.gov (United States)

    Lei, H-P; Yu, X-Y; Xie, H-T; Li, H-H; Fan, L; Dai, L-L; Chen, Y; Zhou, H-H

    2010-04-01

    The objective of this study was to investigate the effects of continuous St. John's wort administration on single-dose pharmacokinetics of bupropion, a substrate of cytochrome P450 (CYP) 2B6, in healthy Chinese volunteers. Eighteen unrelated healthy male subjects participated in this study. The single-dose pharmacokinetics of bupropion and hydroxybupropion were determined before (control) and after a long-term period of St. John's wort intake (325 mg, three times a day for 14 days). Plasma concentrations of bupropion and hydroxybupropion were determined before and at 0.5, 1, 2, 3, 4, 5, 6, 8, 10, 12, 24, 36, 48, 60 and 72 h after dosing. St. John's wort treatment decreased the area under the concentration versus time curve extrapolated to infinity of bupropion in healthy volunteers from 1.4 microg.h ml(-1) (95% confidence interval [CI] = 1.2-1.6 microg.h ml(-1)) after bupropion alone to 1.2 microg.h ml(-1) (95% CI = 1.1-1.3 microg.h ml(-1)) during St. John's wort treatment. St. John's wort treatment increased the oral clearance of bupropion from 108.3 l h(-1) (95% CI = 95.4-123.0 l h(-1)) to 130.0 l h(-1) (95% CI = 118.4-142.7 l h(-1)). No change in the time to peak concentration (t(max)) and the blood elimination half-life (t(1/2)) of bupropion was observed between the control and St. John's wort-treated phases. However, the half-life of hydroxybupropion between two phases had a significant difference by a Student's t test after logarithmic transformation. St. John's wort treatment decreased the half-life of hydroxybupropion from 26.7 h (95% CI = 23.8-29.9 h) to 24.4 h (95% CI = 21.9-27.3 h). St. John's wort decreased, to a statistically significant extent, the plasma concentrations of bupropion, probably mainly by increasing the clearance of bupropion.

  4. Effects of quercetin on pharmacokinetics of cefprozil in Chinese-Han male volunteers.

    Science.gov (United States)

    Jia, Fei-Fei; Tan, Zhi-Rong; McLeod, Howard L; Chen, Yao; Ou-Yang, Dong-Sheng; Zhou, Hong-Hao

    2016-10-01

    1. The primary objective of this study was to evaluate the effects of quercetin on the pharmacokinetics of cefprozil. The secondary objective was to evaluate the safety of the combined use of cefprozil and quercetin. 2. An open-label, two-period, crossover phase I trial among 24 Han Chinese male subjects was conducted. Participants were given 500 mg of quercetin orally once daily for 15 d followed by single dose of cefprozil (500 mg) on day 15. Serum concentrations of cefprozil were then measured in all participants on day 15. A 15-d washout period was then assigned after which a 500 mg dose of cefprozil was administered and measured in the serum on day 36. 3. All subjects completed the trial, and no serious adverse events were reported. We measured mean serum concentrations of cefprozil in the presence and absence of quercetin in all participants. The maximum serum concentration of cefprozil in the presence of quercetin was 8.18 ug/ml (95% CI: 7.55-8.81) versus a maximum cefprozil concentration of 8.35 ug/ml (95% CI: 7.51-9.19) in the absence of quercetin. We conclude that the concurrent use of quercetin has no substantial effect on serum concentrations of orally administered cefprozil. 4. Co-administration of quercetin showed no statistically significant effects on the pharmacokinetics of cefprozil in healthy Chinese subjects.

  5. Pharmacokinetics and bioequivalence of lorazepam tablets in Chinese healthy volunteers

    Institute of Scientific and Technical Information of China (English)

    Xiang-junQIU; Guo-xinHU; Jian-gangWANG; Zong-shunDAI

    2004-01-01

    AIM: To study the pharmacokinetics and bioequivalence of lorazepam tablets in Chinese healthy volunteers. METHODS:Twenty Chinese healthy male volunteers were involved in the study. Each subject received a single dose of 3 mg Lorazepam tested formulation (T, Hubei Zhongtian Airbeck Pharmaceutical Limited Company) or Lorazepam reference formulation (R, Thailand Atlatic Pharmaceutical Limited Company) with a random-

  6. Pharmacokinetics study of amoxycillin and clavulanic acid (8:1)--a new combination in healthy Chinese adult male volunteers using the LC-MS/MS method.

    Science.gov (United States)

    Zhang, Juanhong; Wang, Yinfu; Xie, Hua; Wang, Rong; Jia, Zhengping; Men, Xiandong; Xu, Liting; Zhang, Qiang

    2013-04-01

    New oral granules of amoxicillin and clavulanic acid in 8:1 ratio have recently been developed and approved to conduct clinical trial in China. To date, there has been no report studying the pharmacokinetic characteristics of amoxicillin and clavulanic acid in man. Therefore, it is urgent to investigate the pharmacokinetic properties of amoxicillin and clavulanic acid in man. The aim of the study was to assess the pharmacokinetic properties of amoxicillin and clavulanic acid in 8:1 with different dosage in healthy volunteers and provide support for this drug to obtain marketing authorization in China. A liquid chromatography-tandem mass spectrometry method for determining the concentration of amoxicillin and clavulanic acid in human plasma was developed and applied to this open-label, single- and multiple-dose Pharmacokinetics study. Subjects were randomized to receive a single dose of 1, 2, and 4 pouches of the test granulation of amoxicillin and clavulanic acid in 8:1 ratio (amoxicillin is 250 mg and clavulanic acid is 31.25 mg per pouch). In the single-dose phase, blood samples were collected before dosing and at 0.25, 0.5, 0.75, 1, 1.5, 2, 2.5, 3, 5, 8, 12, and 24 h after drug administration. In the multiple-dose phase, samples were obtained before drug administration on days 1, 2, 3, and 4 to determine the Cmin of amoxicillin and clavulanic acid. In the 4th day, samples were collected from 0.25 to 24 h after drug administration. Profiles of the concentration-time curves of amoxicillin and clavulanic acid were best fitted to two-compartment model. In this group of healthy Chinese subjects, the pharmacokinetics of amoxicillin fitted the linear dynamic feature at doses of 250,500 and 1,000 mg, and not obviously about clavulanic acid at doses of 31.25, 62.5, and 125 mg. The t 1/2 of single dose and multidoses were (1.45 ± 0.12) and (1.44 ± 0.26) h of amoxicillin and (1.24 ± 0.23) and (1.24 ± 0.17) of clavulanic acid, respectively; The AUC0-24 of single dose

  7. BIOAVAILABILITY AND PHARMACOKINETICS OF ANASTROZOLE IN HEALTHY MALE VOLUNTEERS

    Institute of Scientific and Technical Information of China (English)

    安富荣; 崔岚; 刘晓琰; 王平全; 祝德秋; 曹惠明

    2002-01-01

    Objective To evaluate bioavailability and pharmacokinetics of domestic and imported anastrozole tablets. Methods Twenty Chinese healthy male volunteers were enrolled in a randomized crossover study with a single oral dose of 2mg of the two formulations respectively. The anastrozole in plasma was measured by gas chromatography with electron-capture detection. The linear range was 1. 325 ~ 106ng /ml plasma. The extraction recovery rates for plasma concentration of 5.3, 21.2 and 53. Ong/ml were 76.8% ,87.0% and 78.7%, respectively. Inter-day and intra-day precisions of the method were < 9%. Area under concentration-time curve ( AUCo t) , maximum plasma concentration (Cmax) and reach peak time (Tmax) were evaluated by variance analysis and two one-side t-test . Results A two-compartment model was adopted in anastrozole plasma concentration-time data analysis. The main pharmacokinetic parameters of domestic and imported anastrozloe tablets such as Cmax , Tmax, AUCo - t and T1/2β were (36.5 ± 6.9)ng/ml and (35.6 ± 9.4)ng/ml, (1.56-±0.41)hand(1.53 ±0.49)h, (1403.6 ± 321.2)ng'h/mland (1371.6±329.4)ng'h/mi, (42.57 ± 10.15)h and (43.41 ± 8.59)h, respectively, and there were no significant differences between the two formulations. Conclusion Domestic and imported anastrozole tablets were of bioequivalence.The relative bioavailability of the domestic tablet was (102.7 ± 5.6)%.

  8. Departure Ceremony for Chinese International Friendship Volunteers Held in Beijing

    Institute of Scientific and Technical Information of China (English)

    An; Xin

    2013-01-01

    <正>The CPAFFC launched the"Program of Chinese International Friendship Volunteers"in 2012.On July 18 this year,it joined with the Program’s organizer,Zhongxie Human Resource Consulting Center(Zhongxie HR),to

  9. Bioequivalence Study of Donepezil Hydrochloride Tablets in Healthy Male Volunteers

    OpenAIRE

    Supanimit Teekachunhatean; Sukit Roongapinun; Nutthiya Hanprasertpong; Siriluk Aunmuang; Noppamas Rojanasthien

    2012-01-01

    The objective of this study was to investigate the bioequivalence of two formulations of 5 mg donepezil HCL tablets: Tonizep as the test and Aricept as the reference. The two products were administered as a single oral dose according to a randomized two-phase crossover with a 3-week washout period in 20 healthy Thai Male volunteers. After drug administration, serial blood samples were collected over a period of 216 hours. Plasma donepezil concentrations were measured by high performance liqui...

  10. Population pharmacokinetics of olprinone in healthy male volunteers

    Directory of Open Access Journals (Sweden)

    Kunisawa T

    2014-03-01

    Full Text Available Takayuki Kunisawa,1 Hidefumi Kasai,2 Makoto Suda,2 Manabu Yoshimura,3 Ami Sugawara,3 Yuki Izumi,3 Takafumi Iida,3 Atsushi Kurosawa,3 Hiroshi Iwasaki3 1Surgical Operation Department, Asahikawa Medical University Hospital, Hokkaido, Japan; 2Clinical Study Management Division, Bell Medical Solutions Inc, Tokyo, Japan; 3Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical University, Hokkaido, Japan Background: Olprinone decreases the cardiac preload and/or afterload because of its vasodilatory effect and increases myocardial contractility by inhibiting phosphodiesterase III. Purpose: The objective of this study was to characterize the population pharmacokinetics of olprinone after a single continuous infusion in healthy male volunteers. Methods: We used 500 plasma concentration data points collected from nine healthy male volunteers for the study. The population pharmacokinetic analysis was performed using the nonlinear mixed effect model (NONMEM® software. Results: The time course of plasma concentration of olprinone was best described using a two-compartment model. The final pharmacokinetic parameters were total clearance (7.37 mL/minute/kg, distribution volume of the central compartment (134 mL/kg, intercompartmental clearance (7.75 mL/minute/kg, and distribution volume of the peripheral compartment (275 mL/kg. The interindividual variability in the total clearance was 12.4%, and the residual error variability (exponential and additive were 22.2% and 0.129 (standard deviation. The final pharmacokinetic model was assessed using a bootstrap method and visual predictive check. Conclusion: We developed a population pharmacokinetic model of olprinone in healthy male adults. The bootstrap method and visual predictive check showed that this model was appropriate. Our results might be used to develop the population pharmacokinetic model in patients. Keywords: phosphodiesterase III inhibitor, men, pharmacokinetic model

  11. Validation of the Beliefs against Volunteering Scale among Chinese Adolescents in Hong Kong

    Science.gov (United States)

    Law, Ben M. F.; Shek, Daniel T. L.

    2011-01-01

    Participation in volunteer service is an indicator of quality of life. This study attempts to validate the Beliefs Against Volunteering Scale (BAV), an assessment of the negative beliefs about volunteerism among Chinese adolescents in Hong Kong. The BAV was administered to 5,946 Chinese adolescents. The BAV and its subscales were found to be…

  12. Characteristics of volunteers and non-volunteers for voluntary counseling and HIV testing among unmarried male undergraduates.

    Science.gov (United States)

    Adewole, D A; Lawoyin, T O

    2004-06-01

    The 2001 HIV sero-prevalence survey in Nigeria revealed a rate of 5.8 percent with those under the age of 25 years having the highest prevalence rate. Most University students fall within this age group. This study is part of a larger study on the sexual behavior of youths and young adults and was designed to compare the characteristics of volunteers and non-volunteers for voluntary confidential counseling and HIV testing (VCT) among males. Six hundred and nine male undergraduate students were randomly selected and enrolled for the study. Data were collected using a pre-tested questionnaire. Of the 609, 51 (8.3%) volunteered to have their blood screened for HIV. All volunteers who received pre-test counseling went for the HIV test. Volunteers were significantly older than the non-volunteers (Pmothers who had completed secondary education (P<0.00001, (P=0.02). Among the 51 volunteers, 8 (15.7%) tested positive. Those who tested positive were less likely to have lived with parents, and were all sexually experienced. Those who screened positive were also more likely to be currently sexually active and to have fathers with low level of education. Three (5.9%) of volunteers did not return for results and posttest counseling. One of the three was positive for HIV. Of those who tested positive, 3 (37.5%) reported not using the condom at all, while the rest were using it only occasionally. VCT among the youths is possible however, small numbers encountered in the study is a limitation and there is a need to replicate this study using larger numbers. Tertiary institutions should provide VCT services for the students where they can be counseled appropriately and continuously throughout their stay in the institution. This hopefully will reduce the number of new HIV cases seen.

  13. Volunteering

    OpenAIRE

    Hustinx, Lesley; Handy, Femida; Cnaan, Ram A

    2010-01-01

    In recent decades, there has been a burgeoning interest in the study of volunteering, and the number of publications devoted to volunteering has grown exponentially. In this chapter, we examine emerging theories and new directions in volunteering research. First, we discuss multi-level perspectives that try to understand volunteering in complex interaction with the organizational and institutional context. Next, we present process-oriented approaches that focus on the experience of volunteeri...

  14. Safety of a New Compact Male Intermittent Catheter: Randomized, Cross-Over, Single-Blind Study in Healthy Male Volunteers

    DEFF Research Database (Denmark)

    Bagi, Per; Hannibalsen, Jane; Permild, Rikke

    2011-01-01

    Introduction: A new compact male intermittent catheter was compared with a regular intermittent male catheter in terms of safety and acceptability. Methods: In this randomized, single-blind, cross-over study, healthy male volunteers were catheterized twice with a compact catheter and twice with a...

  15. Family influence on volunteering intention and behavior among Chinese adolescents in Hong Kong.

    Science.gov (United States)

    Law, Ben M F; Shek, Daniel T L

    2009-01-01

    Based on the responses of 5,946 adolescents (mean age = 14.77), the relationships among family influence, adolescents' volunteering intention, and volunteering behavior in a Chinese context were examined. A 9-item Chinese Family Influence on Adolescent Volunteerism Scale (C-FIAV) was used to measure nine kinds of influence of the family (such as family support) which could be subsumed under two underlying domains (positive family influence and extrinsic family influence). Results showed that family support, family belief, and family modeling were positively associated with both intention and behavior. Family reward and coercion were negatively associated with both intention and behavior. Family belief in volunteerism was the most critical factor. Grade and gender differences were found only in the associations between family influence and volunteering intention. Path models showed that positive and extrinsic family influence had an effect on volunteering behavior directly or via the mediation of volunteering intention. Implications and limitations are discussed.

  16. Quantification of toy sword kinematics with male pediatric volunteers.

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    Beeman, Stephanie M; Rowson, Steven; Duma, Stefan M

    2014-01-01

    While extensive research in toy safety has been performed, data is unavailable with regard to the kinematics of toy swords. To improve upon design criteria, knowledge of a child’s physical capacity is essential. The purpose of this study was to quantify the linear and angular velocities generated by children swinging toy swords. A total of 36 male subjects, ages 4-14 years old, each participated in one trial. Subjects were instructed to swing a toy sword as fast and hard as possible for ~10 seconds. A Vicon motion analysis system was used to capture subject and sword kinematics. Peak linear and angular sword velocities were calculated. A strong correlation was identified between age and velocity. The 8-14 year old males were not significantly different. The 4 year old males generated significantly lower velocities than the 8-14 year old males. The 6 year old males produced significantly lower velocities than the 10- 14 year old males. It was concluded that age had a significant effect on the linear and angular velocities generated by children. The trends observed within this study likely result from typical pediatric and adolescent development. By accounting for the physical capabilities of a specific population, toys can be designed with decreased inherent risks of injury.

  17. PHARMACOKINETICS OF OXYMATRINE IN 18 CHINESE VOLUNTEERS BY INTRA-MUSCULAR ROUTE

    Institute of Scientific and Technical Information of China (English)

    费艳秋; 孙黎; 刘晓琰; 安富荣; 王平全; 祝德秋; 施安国

    2002-01-01

    Objective To establish a method for determining oxynatrine in human plasma and to study the pharmacokinetics of matrine injection. Methods 18 healthy male volunteers were injected a single dose of 300mg matrine intra-musclularly. The serum concentrations of oxymatrine were determined by HPLC. Data of serum level-time were disposed with 3P87 software. Results The serum concentration-time curves of the oxymatrine appeared to fit two-compartment open model. The major pharmacokinetic parameters of oxynatrine were: Cmax (4.18 ± 1.28)mg/L, Tmuax (23.68 ± 8.89)min, T1 /2α ( 32 .13 ± 9.56)min, T1 /2β (130.40 ±43.66)min, CL (0.35 ± 0. 27 ) L /min , K (0. 0066 ± 0. 0055 ) /min , AUC (613.05 ± 173 . 69 ) min @mg /L. Conclusion The present study provides pharmacokinetics of matrine injection in healthy Chinese volunteers.

  18. The study of bioavailability and bioequivalence of oseltamivir in Chinese health volunteers

    Institute of Scientific and Technical Information of China (English)

    LI Jing-lai; CUI Meng-cun; WANG Xiao-ying; QIAO Jian-zhong; YUAN Su-lan; ZHANG Zhen-qing; RUAN Jin-xiu; ZHONG Wu; LI Song

    2008-01-01

    Objective To evaluate the bioavailability and bioequivalence of oseltamivir capsule in Chinese health male volunteers. Methods A randomized, two period, two treatment, two sequence crossover bioequivalence trial was designed, 24 Chinese health volunteers were randomly divided into two groups, each group was orally given single dose oseltamivir phosphate (tamifla) or AMMS 607 capsule. The active metabolite oseltamivir carboxylate of oseltamivir in the plasma were determined by liquid chromatographic-tandem mass spectrometric (LC-MS/MS) method. The pharmacokinetics parameters and relative bioavailability were calculated to evaluate the bioequivalence of AMMS 607 and tamifla. Results Cmax of the AMMS 607 and tamifla were 602.07±153.27 ng·mL-1 and 620.09±132.39 ng·mL-1 respectively; tmax were 4.2± 1.1 h and 4.8±1.0 h; t1/2β were 6.60±0.87 h and 6.61±0.83 h;MRT were 10.00±1.77 h and 10.40 ±1.62 h; AUC0-24 were 6285.88±1083.66 ng·h·mL-1 and 6546.01±1199.32 ng·h·mL-1; Compared with the reference of tamifla capsule, the bioavailability F0-tn of AMMS 607 capsule was 99.5±27.7 %. The main pharmacokinetics parameters of AUC0-24, Cmax and Tmax showed no statistically significant difference between the two capsules. Conclusions The AMMS 607 capsule and tamifla capsule are bioequivalent.

  19. Rapid response to lipids profile and leukocyte gene expression after rosuvastatin administration in Chinese healthy volunteers

    Institute of Scientific and Technical Information of China (English)

    HUA Cong-xiao; LI Yi-shi; LIU Yu-qing; LIU Hong; LI Na; WU Ying; XU Li; HUANG Yi-ling

    2008-01-01

    Background Statins are potent lipid-lowering agents widely used in medicaI practice.There has been growing evidence suggesting the pleiotropic effects of statins In addition to the lipid-lowering effect.However,it is still unclear how rapidly the beneficial effects of statins occur.The transcriptome of peripheral blood cells can be used as a sensor to drug therapy.The purpose of the study was to investigate the acute effects of rosuvastatin both on lipids profile and gene expression of peripheral leukocytes following therapy with a single dose of rosuvastatin.Methods Thirty healthy Chinese male volunteers were enrolled.The serum lipids,high-sensitivity C-reactive protein,and plasma fibrinogen were determined before and 72 hours after administration of 20 mg of rosuvastatin.The differentially expressed genes of peripheral leukocytes after administration of rosuvastatin were screened using human oligonucleotide microarray gene expression chips.Then four of the differentially expressed genes including ATM,CASP8,IL8RB and S100B were verified by real-time polymerase chain reaction(PCR).Results Rosuvastatin decreased both serum total cholesterol and low-density lipoprotein cholesterol significantly 72 hours after administration of a single dose of 20 mg rosuvastatin.However,no significant changes occurred in blood high-density lipoprotein cholesterol,triglycerides,C-reactive protein and fibrinogen after the treatment.A total of 24 genes were differentially expressed after the treatment.They were involved in important cell biological processes such as cytokine-cytokine receptor interaction,apoptosis signaling,etc.Conclusions Rosuvastatin rapidly modulates the serum lipids and affects the gene expression of peripheral leukocytes in healthy volunteers.This finding provides some new clues for further studies on its potential pleiotropic effects.

  20. Pharmacokinetic Properties of Single- and Multiple-Dose Pitavastatin Calcium Tablets in Healthy Chinese Volunteers

    Directory of Open Access Journals (Sweden)

    Zhu Luo, MD

    2015-12-01

    Conclusions: In healthy Chinese volunteers, single dosing of 1 mg, 2 mg, and 4 mg pitavastatin resulted in linear plasma pharmacokinetic properties. Compared with single dosing, multiple dosing of pitavastatin showed different distribution and elimination characteristics. Sex did not appear to affect the pharmacokinetic properties of pitavastatin. Chictr.org identifier: ChiCTR-OO-13004294.

  1. Immigrants as Active Citizens: Exploring the Volunteering Experience of Chinese Immigrants in Vancouver

    Science.gov (United States)

    Guo, Shibao

    2014-01-01

    Despite the fact that immigration has played an important role in transforming Canada into an ethno-culturally diverse and economically prosperous nation, immigrants themselves are often criticised as passive citizens. This study attempts to deconstruct this myth by investigating the volunteering experiences of Chinese immigrants in Vancouver. The…

  2. Beliefs about Volunteerism, Volunteering Intention, Volunteering Behavior, and Purpose in Life among Chinese Adolescents in Hong Kong

    OpenAIRE

    2009-01-01

    The relationships among beliefs about volunteerism, volunteering intention, volunteering behavior, and purpose in life were examined in this study. A total of 5,946 participants completed a series of scales, including the Revised Personal Functions of Volunteerism Scale, Volunteering Intention Scale, and Purpose in Life Scale. The results showed that participants whose purpose in life had different levels also had varied prosocial beliefs about volunteerism, volunteering intention, and volunt...

  3. REPORT OF HLA DISTRIBUTION IN 2315 VOLUNTEER DONORS OF CHINESE BONE MARROW BANK FROM NORTHWEST CHINA

    Institute of Scientific and Technical Information of China (English)

    Jin Tianbo; Gao Ya; Zhang Hongbo; Zhao Junhai; Lai Jianghua; Lai Shuping; Li Shengbin

    2005-01-01

    Objective To report the HLA data of volunteer donors of Chinese bank from Northwest China and characterize the distribution of HLA genes in Northwest China. Methods HLA-A, B antigens of 2315 volunteer donors were examined by the method of microlymphocytetoxicity (MLT) test .The antigen frequencies(AF) were assessed by directly counting; and based on that gene frequencies(GF) were calculated. HLA data from other population were collected and distribution characteristics were compared. With the raw data, Hardy-Weinberg equilibrium, statistical parameters of forensic medicine interest for HLA were computed. Results A total of 18 specific antigens were detected in HLA-A and the most frequent antigen was A2 . AF and GF were 0.5136 and 0.3026, respectively. A total of 42 specific antigens were detected in HLA-B and the most frequent antigen was A13. Its AF and GF were 0.1978 and 0.1044, respectively. The heterozygosity(H), polymorphism information content(PIC), discrimination power(DP) and probability of paternity exclusion (PPE) of HLA-A were 0.8215, 0.8212, 0.9356 and 0.7798 accordingly; while H,PIC, DP and PPE of HLA-B were 0.9322, 0.9322, 0.9878 and 0.9528. Conclusion The polymorphism of HLA-A,B genes is characteristic in Chinese. In this research, the genetic trait of HLA in 2315 volunteers is consistent with Northern Han population.

  4. Beliefs about volunteerism, volunteering intention, volunteering behavior, and purpose in life among Chinese adolescents in Hong Kong.

    Science.gov (United States)

    Law, Ben M F; Shek, Daniel T L

    2009-09-01

    The relationships among beliefs about volunteerism, volunteering intention, volunteering behavior, and purpose in life were examined in this study. A total of 5,946 participants completed a series of scales, including the Revised Personal Functions of Volunteerism Scale, Volunteering Intention Scale, and Purpose in Life Scale. The results showed that participants whose purpose in life had different levels also had varied prosocial beliefs about volunteerism, volunteering intention, and volunteering behavior. Purpose in life was associated more strongly with prosocial value function than with other types of beliefs (except understanding function). When different beliefs are grouped, the correlation between purpose in life and other-serving beliefs was higher than that between purpose in life and self-serving beliefs. Purpose in life was also associated with volunteering intention and behavior. Path analyses showed that purpose in life predicted volunteering behavior via beliefs and intention. While other-serving beliefs predicted volunteering behavior directly, self-serving beliefs did not have such direct effect.

  5. Beliefs about Volunteerism, Volunteering Intention, Volunteering Behavior, and Purpose in Life among Chinese Adolescents in Hong Kong

    Directory of Open Access Journals (Sweden)

    Ben M. F. Law

    2009-01-01

    Full Text Available The relationships among beliefs about volunteerism, volunteering intention, volunteering behavior, and purpose in life were examined in this study. A total of 5,946 participants completed a series of scales, including the Revised Personal Functions of Volunteerism Scale, Volunteering Intention Scale, and Purpose in Life Scale. The results showed that participants whose purpose in life had different levels also had varied prosocial beliefs about volunteerism, volunteering intention, and volunteering behavior. Purpose in life was associated more strongly with prosocial value function than with other types of beliefs (except understanding function. When different beliefs are grouped, the correlation between purpose in life and other-serving beliefs was higher than that between purpose in life and self-serving beliefs. Purpose in life was also associated with volunteering intention and behavior. Path analyses showed that purpose in life predicted volunteering behavior via beliefs and intention. While other-serving beliefs predicted volunteering behavior directly, self-serving beliefs did not have such direct effect.

  6. Acquirement of a new male sterile germplasm of Chinese jujube

    Institute of Scientific and Technical Information of China (English)

    WANG Jiurui; LIU Ling; LIU Mengjun; ZHOU Junyi

    2007-01-01

    A male sterile germplasm of Chinese jujube(Ziziphus jujuba Mill.),named 'male sterile No.1'(JMS1),was firstly identified from a natural population through studies of pollen amount and vitality and its anatomy.Its microspores got massed and then disaggregated after the tetrad stage during pollen development.Then its anthers became empty,or only pollen vestiges remained in the yellow buds.The pollen became abortive after the tetrad stage.Hypertrophy and hyperplasia of tapetum at the tetrad stage were related to pollen abortion.In view of its moderate could be used as a worthwhile female parent in the cross breeding of Chinese jujube.

  7. Comparative pharmacokinetic and pharmacodynamic evaluation of branded and generic formulations of meloxicam in healthy male volunteers

    Directory of Open Access Journals (Sweden)

    Del Tacca M

    2013-07-01

    Full Text Available Mario Del Tacca,1,2 Giuseppe Pasqualetti,3 Giovanni Gori,1 Pasquale Pepe,1 Antonello Di Paolo,2 Marianna Lastella,2 Ferdinando De Negri,1 Corrado Blandizzi2 1Clinical Pharmacology Centre for Drug Experimentation, Pisa University Hospital, 2Department of Clinical and Experimental Medicine, 3Geriatrics Unit, University of Pisa, Pisa, Italy Purpose: The primary aim of the present study was to assess the pharmacokinetic bioequivalence between a generic formulation of meloxicam 15 mg tablets (Meloxicam Hexal and its respective brand product (Mobic, in order to verify whether the generic product conforms to the regulatory standards of bioequivalence in the postmarketing setting. As a secondary exploratory aim, the pharmacodynamic effects of the two formulations were also evaluated by means of rating scales following hyperalgesia induced by cutaneous freeze injury. Subjects and methods: A single 15 mg dose of generic or branded meloxicam tablets was administered to 24 healthy male volunteers in a crossover fashion. Plasma samples, collected for 24 hours after dosing, were assayed for meloxicam concentration by a validated high-performance liquid chromatography method. Results: The analysis of pharmacokinetic parameters did not show any significant difference between the two meloxicam formulations: the 90% confidence intervals fell within the acceptance range of 80%–125% (0.84–1.16 for area under the curve [0–24], and 0.89–1.23 for peak concentration. No difference in the pharmacodynamic end point was observed between the two groups. Conclusion: The pharmacokinetic profiles of the two meloxicam formulations confirm the regulatory criteria for bioequivalence; pharmacodynamic data indicate a similar antihyperalgesic effect. The two formulations can be used interchangeably in the clinical setting. Keywords: meloxicam, pharmacokinetics, healthy volunteers, generic drug, bioequivalence, postmarketing

  8. Pharmacokinetic study of inosiplex tablets in healthy Chinese volunteers by hyphenated HPLC and tandem MS techniques

    Institute of Scientific and Technical Information of China (English)

    Mo Chen; Yuan Zhang; Xiao-Ting Que; Ya Ding; Lin Yang; Ai-Dong Wen; Tai-Jun Hang

    2013-01-01

    Inosiplex is a compound formulation composed of inosine and p-acetaminobenzoic acid (PABA) salt of N,N-dimethylamino-2-propanol (DIP). This study was to investigate the clinical plasma pharmacokinetic properties of DIP and PABA after single and multiple oral doses of inosiplex tablets in healthy Chinese volunteers. The established LC/MS/MS method for plasma DIP determination had a linear range of 0.02-10 mg/mL, and the HPLC method for plasma PABA determination had a linear range of 0.05-40 mg/mL. Linear pharmacokinetic characteristics were found with single oral doses of 0.5, 1.0 and 2.0 g. No obvious accumulation effects were observed for DIP and PABA.

  9. Fluorescence detection of tramadol in healthy Chinese volunteers by high-performance liquid chromatography and bioequivalence assessment.

    Science.gov (United States)

    Zhou, Xiao; Liu, Ji

    2015-01-01

    This study developed a revised high-performance liquid chromatography fluorescence method to determine plasma tramadol concentration, and thereby to examine the bioequivalence of two tramadol formulations among healthy male Chinese volunteers. The study used a double-blind, randomized, 2×2 crossover-design principle. Calculated pharmacokinetic parameters for both formulations were consistent with previous reports. According to the observation of vital signs and laboratory measurement, no subjects had any adverse reactions. The geometric mean ratios (90% confidence interval) of the test drug/reference drug for tramadol were 100.2% (95.3%-103.4%) for the area under the plasma concentration-time curve (AUC) from time zero to the last measurable concentration, 99.6% (94.2%-102.7%) for the AUC from administration to infinite time, and 100.8% (93.1%-106.4%) for maximum concentration. For the 90% confidence intervals of the test/reference AUC ratio and maximum concentration ratio of tramadol, both were in the acceptance range for bioequivalence. According to the two preparations by pharmacokinetic parameter statistics, the half-life, mean residence time, and clearance values showed no significant statistical differences. Therefore, the conclusion of this study was that the two tramadol formulations (tablets and capsules) were bioequivalent.

  10. Fluorescence detection of tramadol in healthy Chinese volunteers by high-performance liquid chromatography and bioequivalence assessment

    Directory of Open Access Journals (Sweden)

    Zhou X

    2015-02-01

    Full Text Available Xiao Zhou, Ji Liu Department of Anesthesia, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China Abstract: This study developed a revised high-performance liquid chromatography fluorescence method to determine plasma tramadol concentration, and thereby to examine the bioequivalence of two tramadol formulations among healthy male Chinese volunteers. The study used a double-blind, randomized, 2×2 crossover-design principle. Calculated pharmacokinetic parameters for both formulations were consistent with previous reports. According to the observation of vital signs and laboratory measurement, no subjects had any adverse reactions. The geometric mean ratios (90% confidence interval of the test drug/reference drug for tramadol were 100.2% (95.3%–103.4% for the area under the plasma concentration–time curve (AUC from time zero to the last measurable concentration, 99.6% (94.2%–102.7% for the AUC from administration to infinite time, and 100.8% (93.1%–106.4% for maximum concentration. For the 90% confidence intervals of the test/reference AUC ratio and maximum concentration ratio of tramadol, both were in the acceptance range for bioequivalence. According to the two preparations by pharmacokinetic parameter statistics, the half-life, mean residence time, and clearance values showed no significant statistical differences. Therefore, the conclusion of this study was that the two tramadol formulations (tablets and capsules were bioequivalent. Keywords: tramadol hydrochloride, in vitro release, pharmacokinetic, bioequivalence, fluorescence detector

  11. Pharmacokinetics of terazosin enantiomers in healthy Chinese male subjects.

    Science.gov (United States)

    Liu, Man; Zhang, Dan; Yang, Man; Zhao, Ting; Wang, Xiaolin; Zhang, Yanan; Han, Jing; Liu, Huichen

    2012-12-01

    The purpose of this study was to elucidate the pharmacokinetics of terazosin enantiomers in healthy Chinese male subjects. After a single oral dose of 2-mg terazosin, the plasma concentrations of terazosin enantiomers were measured over the course of 48 h in 12 healthy subjects. The plasma concentrations of (+)-(R)-terazosin at all time points were higher than those of (-)-(S)-terazosin. The area under the plasma concentration-time curve (AUC(0-∞) ) and maximum plasma concentration of (+)-(R)-terazosin were significantly greater than those of the (-)-(S)-terazosin (P < 0.01, respectively). The R/S ratio of AUC(0-∞) of terazosin was 1.68. For the first time, it was proven that the pharmacokinetics of terazosin was stereoselective in healthy Chinese male subjects.

  12. Toxicokinetics and acute effects of MTBE and ETBE in male volunteers.

    Science.gov (United States)

    Johanson, G; Nihlén, A; Löf, A

    1995-12-01

    Methyl tertiary butyl ether (MTBE) is widely used in gasoline as an oxygenator and octane enhancer. There is also an interest in using the ethyl tertiary butyl (ETBE) and methyl tertiary amyl (TAME) ethers. We measured the blood, water, and olive oil/air partition coefficients in vitro of MTBE, ETBE, TAME and tertiary butyl alcohol (TBA), a metabolite of MTBE and ETBE. The results indicate similar uptake and distribution behavior for the three ethers and a slight affinity for fatty tissues. The partition coefficients of TBA indicate that this metabolite is not excreted via the lungs to any great extent and that it is preferentially distributed in body water. Further, we exposed 10 healthy male volunteers to MTBE vapor at 5, 25 and 50 ppm for 2 h during light physical exercise. Uptake and disposition were studied by measuring MTBE and TBA in inhaled and exhaled air, blood and urine. Low uptake, high post-exposure exhalation, and low blood clearance indicate slow metabolism of MTBE relative to many other solvents. A low recovery of TBA in urine (below 1% of uptake) indicates further metabolism of TBA. The concentration of MTBE and TBA in blood was proportional to exposure level suggesting linear kinetics up to 50 ppm. The half life of 7-10 h in blood and urine indicates that TBA would be more suitable than the parent compound as a biomarker for MTBE exposure. Subjective ratings (discomfort, irritative symptoms, CNS effects) and eye (redness, tear film break-up time, conjunctival damage, blinking frequency) and nose (peak expiratory flow, acoustic rhinometry, inflammatory markers in nasal lavage) measurements indicated no or minimal effects of MTBE.

  13. Safety and pharmacokinetics of dicloxacillin in healthy Chinese volunteers following single and multiple oral doses

    Directory of Open Access Journals (Sweden)

    Wu GL

    2015-10-01

    Full Text Available Guolan Wu, Yunliang Zheng, Huili Zhou, Xingjiang Hu, Jian Liu, You Zhai, Meixiang Zhu, Lihua Wu, Jianzhong Shentu Research Center for Clinical Pharmacy, State Key Laboratory for Diagnosis and Treatment of Infectious Disease, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China Background: Dicloxacillin, a semisynthetic isoxazolyl penicillin antibiotic, has antimicrobial activity against a wide variety of gram-positive bacteria including Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumonia, Streptococcus epidermidis, Streptococcus viridans, Streptococcus agalactiae, and Neisseria meningitidis. The objective of this study was to evaluate the safety and pharmacokinetic profile of dicloxacillin after single and multiple oral dose in healthy Chinese volunteers.Methods: A single-center, open-label, randomized, two-phase study was conducted in 16 subjects. In the single-dose phase, subjects were randomly assigned to receive single doses of 0.25, 0.5, 1.0, and 2.0 g of dicloxacillin sodium capsule in a 4-way crossover design with a 5-day washout period between administrations. In the multiple-dose phase, subjects were assigned to receive 0.25 or 0.5 g every 6 hours for 3 days in a 2-way crossover design. Plasma and urine pharmacokinetic samples were assayed by a validated high-performance liquid chromatography-tandem mass spectrometry method. Pharmacokinetic parameters were calculated and analyzed statistically. Safety assessments were conducted throughout the study.Results: Following a single oral dose of 0.25–2.0 g dicloxacillin sodium, the maximum plasma drug concentration (Cmax and the corresponding values for the area under the concentration–time curve from 0 to 10 hours (AUC0–10 h increased in a dose-proportional manner. The mean elimination half-life (t1/2 was in the range of 1.38–1.71 hours. Dicloxacillin was excreted in its unchanged form via the kidney, with no

  14. Bioequivalence study of a generic Risperidone (Iperdal® in healthy Thai male volunteers

    Directory of Open Access Journals (Sweden)

    Werawath Mahatthanatrakul

    2008-05-01

    Full Text Available The objective of this study was to compare the rate and extent of absorption of a generic risperidone (Iperdal® with a reference formulation (Risperdal® when given orally. The study was an open label, randomized, two-period, two-sequence,single dose cross-over design with a 2 weeks washout period in 16 healthy Thai male volunteers. Single oral dose of two 2-mg tablets of risperidone were administered and serial blood samples were collected from the antecubital vein before and at0.17, 0.33, 0.5, 0.75, 1.0, 1.5, 2.0, 3.0, 4.0, 6.0, 8.0, 12, 24 and 48 hours post dose. Risperidone plasma concentrations were assayed using a validated High Performance Liquid Chromatographic (HPLC-UV method modified from Avenosoet al. (2000. Pharamcokinetic parameters i.e. Cmax, AUC0à48 and Tmax were analyzed by noncompartment analysis. Variations of the data were analyzed by “Two Way Analysis of Variance” (ANOVA. Statistics were tested as stated in USP 28 guidelinefor bioequivalence study. The maximum concentration (Cmax, ng/ml of risperidone for the innovator and the generic product were 31.11±17.24 (range 5.64-56.78 and 32.58±19.77 (range 5.29-84.56 ng/ml, respectively. The area under theplasma concentration-time curve (AUC0®48 of the innovator and the generic product were 160.64±152.89 (range 18.57- 550.32 and 144.03±127.37 (range 16.27-456.0 ng.hr/ml, respectively. The time to maximum concentration (Tmax of theinnovator and the generic product were 0.97±0.41(range 0.5-2 and 1.02±0.32 (range 0.5-1.5 hr, respectively. The 90% confidence interval of the ratio of the ln-transformed of Cmax and AUC0à48 of both preparations were 89.39-112.99% and80.02-107.28% respectively which were within the acceptance range of 80.00-125.00%. Therefore, it can be concluded that both preparations used in this study are bioequivalent in terms of both the rate and extent of absorption.

  15. Bioequivalence study of two imatinib formulations after single-dose administration in healthy Korean male volunteers.

    Science.gov (United States)

    Jung, J A; Kim, N; Yang, J-S; Kim, T-e; Kim, J-R; Song, G-S; Kim, H; Ko, J W; Huh, W

    2014-12-01

    Imatinib mesylate is effective for chronic myeloid leukaemia and gastrointestinal tumours. We aimed to evaluate the pharmacokinetics of a 200-mg imatinib tablet compared to 2×100-mg imatinib tablets in order to meet the regulatory requirements for marketing in Korea.An open-label, randomized, single-dose, 2-period, 2-treatment cross-over study was conducted in 28 healthy Korean male volunteers. Subjects were administered a 200-mg imatinib tablet and 2×100-mg imatinib tablets under a fasting state according to a randomly assigned order with a 2-week wash-out period. Serial blood samples were collected up to 72 h post-dose. The pharmacokinetic parameters were calculated using non-compartmental methods.A total of 28 subjects were enrolled and 23 subjects completed the study. There were no serious adverse events during the study. 23 mild to moderate adverse events were reported (11 events with 200-mg imatinib vs. 12 events with 2×100-mg imatinib) and subjects recovered without sequelae. The Cmax value was 922.8±318.8 μg/L at 3.15 h for 200-mg imatinib tablet, and 986.3±266.0 μg/L at 2.91 h for the 2×100-mg imatinib tablet. The AUClast of 200-mg and 2×100-mg tablets were 13 084.3±39.1 and 14 131.7±3 826.2 h · μg/L, respectively. The geometric mean ratios (90% confidence intervals) for Cmax and AUClast were 0.9121 (0.8188, 1.0161) and 0.9558 (0.8685, 1.0519), respectively.A newly developed 200-mg imatinib tablet was bioequivalent to 2×100-mg imatinib tablets in healthy Korean subjects. A single-dose of either of the 2 formulations was generally well tolerated.

  16. Bioequivalence study of two losartan formulations administered orally in healthy male volunteers.

    Science.gov (United States)

    Bienert, Agnieszka; Brzezińiski, Rafał; Szałek, Edyta; Dubai, Vitali; Grześkowiak, Edmund; Dyderski, Stanisław; Drobnik, Leon; Wolc, Anna; Olejniczak-Rabinek, Magdalena

    2006-01-01

    The bioavailability of a new losartan preparation (2-butyl-4-chloro-1-[p-(o-1H-tetrazol-5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt, CAS 114798-26-4) was compared with the reference preparation of the drug in 24 healthy male volunteers, aged between 19 and 32. The open, randomized, single-blind two-sequence, two-period crossover study design was performed. Under fasting conditions, each subject received a single oral dose of 100 mg losartan as a test or reference formulation. The plasma concentrations of losartan and its active metabolite were analyzed by a rapid and sensitive HPLC method with UV detection. The pharmacokinetic parameters included AUC0-36h, AUC0-infinity, Cmax, t1/2, and Ke. Values of AUC0-infinity demonstrate nearly identical bioavailability of losartan from the examined formulations. The AUC0-infinity of losartan was 2019.92+/-1002.90 and 2028.58+/-837.45 ng x h/ml for the test and reference formulation, respectively. The AUC0-infinity of the metabolite was 10851.52+/-4438.66 and 11041.18 +/-5015.81 ng x h/ml for test and reference formulation, respectively. The maximum plasma concentration (Cmax) of losartan was 745.94+/-419.75 ng/ml for the test and 745.74+/-329.99 ng/ml for the reference product and the Cmax of the metabolite was 1805.77+/-765.39 and 1606.22 +/-977.22 ng/ml for the test and reference product, respectively. No statistical differences were observed for Cmax and the area under the plasma concentration-time curve for both losartan and its active metabolite. 90 % confidence limits calculated for Cmax and AUC from zero to infinity (AUC0-infinity) of losartan and its metabolite were included in the bioequivalence range (0.8-1.25 for AUC). This study shows that the test formulation is bioequivalent to the reference formulation for losartan and its main active metabolite.

  17. 美洛昔康在中国健康受试者体内的药物动力学研究%PHARMACOKINETICS OF MELOXICAM IN HEALTHY CHINESE VOLUNTEERS

    Institute of Scientific and Technical Information of China (English)

    徐海燕; 钟大放; 肇丽梅; 张逸凡; 张宝军

    2001-01-01

    AIM To assess the pharmacokinetic profile of single doses of meloxicam in healthy Chinese volunteers. METHODS The plasma concentrations of meloxicam after an oral dose of 15 mg to twenty healthy male volunteers were analized by means of a validated HPLC method. The pharmacokinetic parameters were subjected to Shapiro-Wilk test to determine whether these data were fitted to a normal distribution. RESULTS The twenty volunteers can be classified into extensive metabolizers and poor metabolizers according to pharmacokinetic parameters. The main parameters in the two groups obtained were as follows: T1/2 were 21±4 and 38±9 h, AUC0-∞ were 49±10 and 110±8 μg*h*mL-1, respectively. Even the AUC data in extensive metabolizers were 1.7 times as that reported in White volunteers following the same doses of meloxicam. CONCLUSION There were significant individual differences in the pharmacokinetics of meloxicam in Chinese volunteers, which may be due to the genetic polymorphism of CYP2C9.

  18. Symptoms, prostate volume, and urodynamic findings in elderly male volunteers without and with LUTS and in patients with LUTS suggestive of benign prostatic hyperplasia

    NARCIS (Netherlands)

    Eckhardt, MD; van Venrooij, GEPM; Boon, TA

    2001-01-01

    Objectives. To estimate the differences in symptoms, prostate volume, and urodynamic variables of symptom-free elderly volunteers, volunteers with lower urinary tract symptoms (LUTS), and urologic patients with LUTS suggestive of benign prostatic hyperplasia. Methods. The study included 14 male volu

  19. Pharmacokinetics and bioequivalence studies of cefteram pivoxil in healthy Chinese volunteers.

    Science.gov (United States)

    Wei, Fangmi; Zhu, Rong; Zhao, Wenhui; Yang, Jing; Cai, Zheng; Hu, Qin

    2009-01-01

    A simple, sensitive and specific method has been developed for the determination of cefteram in human plasma. Sample preparation was accomplished through protein precipitation with 20% trichloroacetic acid (v/v) and chromatographic separation was performed on a C18 column at 25 degrees C. The mobile phase consisted of methanol-aqueous 20 mM ammonium acetate (18:82, v/v) at flow rate of 1.0 mL/min. Wavelength was set at 235 nm. The lower limit of quantification was 0.04 microg/mL and the assay exhibited a linear range of 0.04-3.2 microg/mL (r=0.9996). The relative recoveries of cefteram from human plasma at three different concentrations were more than 90%. The method was successfully applied to investigate the bioequivalence between two kinds of cefteram pivoxil preparations (test vs reference) in 24 healthy Chinese volunteers. After a single 100 mg dose for the test and reference product, the resulting means of major pharmacokinetic parameters such as AUC(0-t), AUC(0-infinity), Cmax and Tmax of cefteram pivoxil were 4.75 +/- 1.35 vs 4.76 +/- 1.29 microg h/mL, 4.89 +/- 1.36 vs 4.91 +/- 1.29 microg h/mL, 1.65 +/- 0.45 vs 1.73 +/- 0.45 microg/mL and 1.48 +/- 0.59 vs 1.73 +/- 0.45 h, respectively, indicating that these two kinds of preparations were bioequivalent.

  20. Effects of GUASHA on Heart Rate Variability in Healthy Male Volunteers under Normal Condition and Weightlifters after Weightlifting Training Sessions

    Directory of Open Access Journals (Sweden)

    Xingze Wang

    2015-01-01

    Full Text Available Objectives. This paper aims at exploring the effects of GUASHA on heart rate variability between healthy volunteers under normal condition and weightlifters after training sessions. Methods. Ten healthy male volunteers under normal condition and 15 male weightlifters after weightlifting training sessions were recruited into two groups. Electrocardiography was recorded before and immediately after 20-minute GUASHA. HRV was calculated in both the time domain and the frequency domain. Results. Stress index was reduced, while standard deviation of N-N intervals (SDNN, proportion derived by dividing the number of interval differences of successive N-N intervals greater than 50 ms, and root mean square of successive differences (RMSSD were enhanced after GUASHA therapy in the two groups. The changes in SDNN and RMSSD were higher in the healthy men group than in the weightlifters group. In addition, low frequency was decreased whereas high frequency was significantly increased in healthy men after the GUASHA session. Conclusions. GUASHA therapy facilitates the parasympathetic nervous activity and modulates the balance between parasympathetic and sympathetic activities in both healthy men under normal condition and weightlifters after training sessions as indicated. Although the changes of the HRV parameters were similar in both groups, the responsiveness was more pronounced in healthy men than in male weightlifters.

  1. The Area of Secondary Hyperalgesia following Heat Stimulation in Healthy Male Volunteers

    DEFF Research Database (Denmark)

    Hansen, Morten Sejer; Wetterslev, Jørn; Pipper, Christian Bressen;

    2016-01-01

    -individual variation in secondary hyperalgesia elicited by brief thermal sensitization (45°C for 3 min) in healthy volunteers. MATERIAL AND METHODS: Fifty healthy volunteers were included. Areas of secondary hyperalgesia following brief thermal sensitization were investigated by 2 observers on 4 experimental days......, with a minimum interval of 7 days. Additionally, heat pain detection threshold and pain during thermal stimulation (45°C for 1 min.), and the psychological tests Pain Catastrophizing Scale and Hospital Anxiety and Depression Score were applied. RESULTS: For areas of secondary hyperalgesia, an intra...... and above the 3rd quartile considering all included participants. Heat pain detection threshold predicted area of secondary hyperalgesia with an adjusted R2 of 0.20 (P = 0.0006). CONCLUSIONS: We have demonstrated a low intra-individual, and a high inter-individual variation in thermally induced secondary...

  2. Pharmacokinetic and bioequivalence studies of trospium chloride after a single-dose administration in healthy Chinese volunteers.

    Science.gov (United States)

    Zhang, R; Yuan, G; Li, R; Liu, X; Wei, C; Wang, B; Gao, H; Guo, R

    2012-05-01

    The study aimed to compare and evaluate the bioequivalence of a new generic preparation of trospium chloride (CAS NO:10405-02-4) capsule (20 mg, test) and the available import tablet (20 mg , reference) for the requirement of state regulatory criteria in China. A randomized- sequence, 2-period crossover study was conducted in 20 healthy Chinese male volunteers in the fasted state. Blood samples were collected before and 1, 2, 3, 4, 5, 6, 7, 8, 12, 24, 36, 48, 60 h after administration of a single oral dose of 40 mg trospium chloride capsules or tablets, followed by a 7-day washout period. The concentration of trospium chloride was determined by a LC-MS/MS method. Drug And Statistical-Version 2.0 was used to calculate the pharmacokinetics parameters and assess bioequivalence of the two preparations. It was considered bioequivalent if the 90% CIs of the mean ratios (test: reference) for Cmax, AUC0-t and AUC0-∞ were within the range from 80% to 125%, respectively. The main pharmacokinetics parameters of test and reference were as follows: t1/2 was (15.11 ± 3.24) h and (16.00 ± 3.96) h; Tmax was (4.0 ± 1.2) h and (4.1 ± 0.9) h; Cmax was (3.76 ± 1.87) ng·mL - 1 and (3.70 ± 1.89) ng·mL - 1; AUC0-t was (33.51 ± 14.39) ng·mL - 1·h and (33.33 ± 14.88) ng·mL - 1·h, and the AUC0-∞ was (35.20 ± 14.88) ng·mL - 1·h and (35.16±15.17) ng·mL - 1·h. The ratios (test: reference) for Cmax, AUC0-t, and AUC0-∞ were 94.0%~111.7%, 96.4%~106.8%, and 96.1%~105.3%, respectively. No significant differences in pharmacokinetic parameters were found between preparations and periods (p>0.05). No obvious adverse events were monitored throughout the study based on clinical parameters and patient reports.

  3. Non-invasive assessment of phosphate metabolism and oxidative capacity in working skeletal muscle in healthy young Chinese volunteers using 31P Magnetic Resonance Spectroscopy

    Directory of Open Access Journals (Sweden)

    Ming Li

    2016-07-01

    Full Text Available Background. Generally, males display greater strength and muscle capacity than females while performing a task. Muscle biopsy is regarded as the reference method of evaluating muscle functions; however, it is invasive and has sampling errors, and is not practical for longitudinal studies and dynamic measurement during excise. In this study, we built an in-house force control and gauge system for quantitatively applying force to quadriceps while the subjects underwent 31P Magnetic Resonance Spectroscopy (31P-MRS; our aim was to investigate if there is a sex difference of phosphate metabolite change in working muscles in young heathy Chinese volunteers. Methods. Volunteers performed knee-extending excises using a force control and gauge system while lying prone in a Philips 3T Magnetic Resonance (MR scanner. The 31P-MRS coil was firmly placed under the middle of the quadriceps . 31P-MRS measurements of inorganic phosphate (Pi, phosphocreatine (PCr and adenosine triphosphate (ATP were acquired from quadriceps while subjects were in a state of pre-, during- and post-exercise. The PCr, Pi, PCr/Pi, PCr/ATP, pH, work/energy cost ratio (WE, kPCr and oxidative capacity were compared between males and females. Results. A total of 17 volunteers underwent the study. Males: N = 10, age = 23.30 ± 1.25years; females: N = 7, age = 23.57 ± 0.79 years. In this study, males had significantly greater WE (16.33 ± 6.46 vs. 7.82 ± 2.16, p = 0.002 than females. Among PCr, Pi, PCr/Pi, PCr/ATP, pH, kPCr and oxidative capacity at different exercise status, only PCr/Pi (during-exercise, males = 5.630 ± 1.647, females = 4.014 ± 1.298, p = 0.047, PCr/ATP (during-exercise, males =1.273 ± 0.219, females = 1.523 ± 0.167, p = 0.025, and ATP (post-exercise, males = 24.469 ± 3.911 mmol/kg, females = 18.353 ± 4.818 mmol/kg, p = 0.035 had significant sex differences. Males had significantly greater PCr/Pi, but less PCr/ATP than females during exercise, suggesting males had

  4. Muscle activity during stance phase of walking: comparison of males with transfemoral amputation with osseointegrated fixations to nondisabled male volunteers.

    Science.gov (United States)

    Pantall, Annette; Ewins, David

    2013-01-01

    A recent development in prosthetics is the osseointegrated fixation (OF), with improvements in comfort, fatigue, hip movement, and ease of prosthetic attachment reported. However, little information is available regarding muscle function. This study reports on selected gait parameters of the residual limb during the stance phase of level overground walking, focusing on muscle activity. Five males with transfemoral amputation (TFA) with OFs were recruited. Ground reaction force (GRF), lower-limb kinematics, and surface electromyography (sEMG) from residual-limb muscles were recorded. sEMG data were also collected from a group of 10 nondisabled male subjects. Interstance variability of gait parameters was assessed by coefficient of multiple correlations. Repeatability of GRF and hip kinematics was high, whereas repeatability of the sEMG was low for four of the five individuals with TFA. Interstance variability of the sEMG for gluteus medius (GMED) was significantly greater in the group with TFA. The main difference in sEMG between the groups was the phase, with GMED and adductor magnus displaying greater differences than their counterparts in the nondisabled group. Results demonstrate that muscles in the residual limb retain aspects of their previous functional pattern.

  5. Muscle activity during stance phase of walking: Comparison of males with transfemoral amputation with osseointegrated fixations to nondisabled male volunteers

    Directory of Open Access Journals (Sweden)

    Annette Pantall, DO(UK, PhD

    2013-07-01

    Full Text Available A recent development in prosthetics is the osseointegrated fixation (OF, with improvements in comfort, fatigue, hip movement, and ease of prosthetic attachment reported. However, little information is available regarding muscle function. This study reports on selected gait parameters of the residual limb during the stance phase of level overground walking, focusing on muscle activity. Five males with transfemoral amputation (TFA with OFs were recruited. Ground reaction force (GRF, lower-limb kinematics, and surface electromyography (sEMG from residual-limb muscles were recorded. sEMG data were also collected from a group of 10 nondisabled male subjects. Interstance variability of gait parameters was assessed by coefficient of multiple correlations. Repeatability of GRF and hip kinematics was high, whereas repeatability of the sEMG was low for four of the five individuals with TFA. Interstance variability of the sEMG for gluteus medius (GMED was significantly greater in the group with TFA. The main difference in sEMG between the groups was the phase, with GMED and adductor magnus displaying greater differences than their counterparts in the nondisabled group. Results demonstrate that muscles in the residual limb retain aspects of their previous functional pattern.

  6. Effects of grapefruit juice on cortisol metabolism in healthy male Chinese subjects.

    Science.gov (United States)

    Xiao, Ya-Jie; Hu, Miao; Tomlinson, Brian

    2014-12-01

    Grapefruit juice (GFJ) inhibits intestinal CYP3A4 activity and it has been suggested that GFJ may also inhibit renal 11β-hydroxysteroid dehydrogenase 2 (11β-HSD2), which converts cortisol to cortisone. This study examined the effect of GFJ on the urinary excretion of cortisol, cortisone and 6β-hydroxycortisol (6β-OHC) and their ratios to asses these effects. Healthy male Chinese subjects took single doses of GFJ (200, 400, and 600 mL, respectively) at weekly intervals. Urine was collected over 24 h the day before and following GFJ intake. Subsequently, volunteers drank 400 mL GFJ for 7 days and urine was collected from 0 to 4 h daily. GFJ had dose-dependent effects on increasing cortisol excretion (P cortisol to cortisone (P cortisol (P cortisol. It increased the ratio of cortisol to cortisone and this appeared largely due to increased cortisol excretion related to impaired CYP3A4-mediated cortisol metabolism although a true inhibitory effect on 11β-HSD2 in the kidney cannot be excluded.

  7. Effects of a milk product, fermented by Lactobacillus acidophilus and with fructo-oligosaccharides added, on blood lipids in male volunteers

    NARCIS (Netherlands)

    Schaafsma, G.; Meuling, W.J.A.; Dokkum, W. van; Bouley, C.

    1998-01-01

    Objective: To investigate in adult male volunteers the effect of a new fermented milk product, fermented by Lactobacillus acidophilus and with fructo-oligosaccharides added, on blood lipids. Design: Randomized placebo-controlled double-blind two-way cross over trial with two treatment periods of thr

  8. Effects of improved fat meat products consumption on emergent cardiovascular disease markers of male volunteers at cardiovascular risk.

    Science.gov (United States)

    Celada, Paloma; Sánchez-Muniz, Francisco J; Delgado-Pando, Gonzalo; Bastida, Sara; Rodilla, Manuel Espárrago; Jiménez-Colmenero, Francisco; Olmedilla-Alonso, Begoña

    2016-12-01

    High meat-product consumption has been related to cardiovascular disease (CVD). However, previous results suggest the benefits of consuming improved fat meat products on lipoprotein-cholesterol and anthropometric measurements. Present study aims to assess the effect of consuming different Pâté and Frankfurter formulations on emergent CVD biomarkers in male volunteers at increased CVD risk. Eighteen male volunteers with at least two CVD risk factors were enrolled in a sequentially controlled study where different pork-products were tested: reduced-fat (RF), omega-3-enriched-RF (n-3RF), and normal-fat (NF). Pork-products were consumed during 4-week periods separated by 4-week washout. The cardiometabolic index (CI), oxidized low density lipoproteins (oxLDL), apolipoproteins (Apo) A1 and B, homocysteine (tHcys), arylesterase (AE), C-reactive Protein (CRP), tumor necrotic factor-alpha (TNFα), and lipoprotein (a) (Lp(a)) were tested and some other related ratios calculated. AE, oxLDL and Lp(a), AE/HDLc, LDLc/Apo B, and AE/oxLDL rate of change were differently affected (P<0.01) by pork-products consumption. RF increased (P < 0.05) AE, AE/HDLc and AE/oxLDL ratios and decreased TNFα, tHcys; n-3RF increased (P < 0.001) AE, AE/HDLc and AE/oxLDL ratios and decreased (P < 0.05) Lp(a); while NF increased (P<0.05) oxLDL and Lp(a) levels. In conclusion, RF and n-3RF products affected positively the level of some emergent CVD markers. The high regular consumption of NF-products should be limited as significantly increased Lp(a) and oxLDL values. The high variability in response observed for some markers suggests the need to perform more studies to identify targets for RF- and n-3RF-products. Graphical Abstract Emergent CVD markers.

  9. Rapid and Sensitive LC-MS/MS Method for Quantification of Fexofenadine in Human Plasma——Application to a Bioequivalence Study in Chinese Volunteers

    Institute of Scientific and Technical Information of China (English)

    TENG Guo-sheng; TENG Le-sheng; WU Yi; TANG Yun-biao; LIU Lan-ying; GU Jing-kai

    2007-01-01

    A rapid and sensitive liquid chromatography-tandem mass spectrometry method(LC-MS/MS) was developed and validated for the quantification of fexofenadine in human plasma, to conduct comparative bioavailability studies. Human plasma was extracted with a mixture of dichloromethane-diethyl ether( volume ratio 2:3) in a basic environment and the extract was separated on a C18 column with a mobile phase consisting of acetonitrile-methanol-10 mmol/L amspectrometry in the multiple-reaction-monitoring(MRM) mode. The linearity was within a range of 1-1000 ng/mL.The intra- and inter-day precision were <4.1% and <4.8%, respectively, and the accuracy was in the range of 95.0%-105%. The method was applied to the quantification of fexofenadine human plasma from 20 healthy male Chinese volunteers, according to a single dose, randomized, two-way crossover design with a two-week washout period. The mean values of major pharmacokinetic parameters of ρmax, AUC0-48, AUC0-∞, tmax, and t1/2 were determined from the plasma concentration. The analysis of variance(ANOVA) did not show any significant difference between the two products of fexofenadine and 90% confidence intervals fell within the acceptable range for bioequivalence.

  10. Determination of risperidone in human plasma by HPLC-MS/MS and its application to a pharmacokinetic study in Chinese volunteers

    Institute of Scientific and Technical Information of China (English)

    Ming-zhu HUANG; Jian-zhong SHENTU; Junc-hun CHEN; Jian LIU; Hui-li ZHOU

    2008-01-01

    This study presents a rapid, specific and sensitive liquid chromatography/tandem mass spectrometry (LC-MS/MS) assay for determination of risperidone (RIS) in human serum using paroxetine as an internal standard (IS). An Alltima-C 18separation. The analysis was performed by selected reaction monitoring (SRM) method, and the peak area of the m/z 411.3→ 191.1 transition for RIS was measured versus that of the m/z 330.1→192.1 transition for IS to generate the standard curves. The assay linearity of RIS was confirmed over the range 0.25~50.00 ng/ml and the limit of quantitation was 0.05 ng/ml. The linear range corresponds well with the serum concentrations of the analytes obtained in clinical pharmacokinetic studies. Intraday and interday relative standard deviations were 1.85%~9.09% and 1.56%~4.38%, respectively. The recovery of RIS from serum was in the range of 70.20%~84.50%. The method was successfully applied to investigate the bioequivalence between two kinds of tablets (test versus reference products) in 18 healthy male Chinese volunteers. The result suggests that two formulations are bioequivalent.

  11. A rapid and sensitive LC-MS/MS method for determination of lercanidipine in human plasma and its application in a bioequivalence study in Chinese healthy volunteers.

    Science.gov (United States)

    Li, Xiaobing; Shi, Fuguo; He, Xiaojing; Jian, Lingyan; Ding, Li

    2016-09-05

    A rapid and highly sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed and validated for the determination of lercanidipine (LER) in human plasma. The plasma sample was deproteinized with methanol after addition of diazepam (internal standard, IS) and separated on a 38°C Hedera ODS-2 analytical column with a mobile phase of methanol and 5mM ammonium acetate buffer solution containing 0.1% formic acid at an isocratic flow rate of 400μL/min. The detection was performed on an API 4000 tandem mass spectrometer coupled with electrospray ionization (ESI) source in positive ESI mode. Quantification was conducted by multiple reaction monitoring (MRM) of the transitions of m/z 612.2→280.2 for LER and m/z 285.1→193.1 for IS, respectively. The method exhibited high sensitivity (LLOQ of 0.015ng/mL) and good linearity over the concentration range of 0.015-8.0ng/mL. No matrix effect and carry-over effect were observed. The values on both the occasions (intra- and inter-day) were all within 15% at three concentration levels. This robust method was successfully applied in a bioequivalence study to evaluate the pharmacokinetics of LER in 59 healthy male Chinese volunteers after a single oral administration of 10mg LER.

  12. Influence of food on the oral bioavailability of deramciclane from film-coated tablet in healthy male volunteers.

    Science.gov (United States)

    Drabant, Sándor; Nemes, Katalin Balogh; Horváth, Viola; Tolokán, Antal; Grézal, Gyula; Anttila, Markku; Gachályi, Béla; Kanerva, Harri; Al-Behaisi, Samar; Horvai, George; Klebovich, Imre

    2004-11-01

    The effect of a high-fat meal on the oral bioavailability of deramciclane 30 mg tablet was evaluated in 18 healthy male volunteers in a randomised, single dose, two-way crossover study. The drug was administered following an overnight fast or a standardised high-fat breakfast. The plasma concentrations of deramciclane and N-desmethylderamciclane were determined by using a validated HPLC-MS -MS/MS method. An effect of food on the bioavailability was indicated if the 90% confidence interval (CI) for the ratio of geometric means of fed and fasted treatments was not contained in the equivalence limit of 0.8-1.25 for AUC and C(max). The ratios of the mean C(max) and AUC(0-infinity) values of deramciclane were 1.24 (90% CI 1.12-1.38) and 1.31 (90% CI 1.21-1.41) in fed versus fasted subjects, which overlapped but exceeded the equivalence limit. In contrast to the parent compound, the 90% CI of the mean ratios for AUC(0-infinity) and C(max) of N-desmethylderamciclane were within the predefined range. The 24 and 31% increase in C(max) and AUC(0-infinity) of deramciclane, respectively, under fed condition is modest and probably has no clinical significance since it is relatively small compared to the inter-individual variability of these parameters.

  13. The Effect of Chronic Alprazolam Intake on Memory, Attention, and Psychomotor Performance in Healthy Human Male Volunteers

    Directory of Open Access Journals (Sweden)

    Zahid Sadek Chowdhury

    2016-01-01

    Full Text Available Alprazolam is used as an anxiolytic drug for generalized anxiety disorder and it has been reported to produce sedation and anterograde amnesia. In the current study, we randomly divided 26 healthy male volunteers into two groups: one group taking alprazolam 0.5 mg and the other taking placebo daily for two weeks. We utilized the Cambridge Neuropsychological Test Automated Battery (CANTAB software to assess the chronic effect of alprazolam. We selected Paired Associates Learning (PAL and Delayed Matching to Sample (DMS tests for memory, Rapid Visual Information Processing (RVP for attention, and Choice Reaction Time (CRT for psychomotor performance twice: before starting the treatment and after the completion of the treatment. We found statistically significant impairment of visual memory in one parameter of PAL and three parameters of DMS in alprazolam group. The PAL mean trial to success and total correct matching in 0-second delay, 4-second delay, and all delay situation of DMS were impaired in alprazolam group. RVP total hits after two weeks of alprazolam treatment were improved in alprazolam group. But such differences were not observed in placebo group. In our study, we found that chronic administration of alprazolam affects memory but attentive and psychomotor performance remained unaffected.

  14. Orally given gastroprotective capsaicin does not modify aspirin-induced platelet aggregation in healthy male volunteers (human phase I examination).

    Science.gov (United States)

    Sandor, B; Papp, J; Mozsik, Gy; Szolcsanyi, J; Keszthelyi, Zs; Juricskay, I; Toth, K; Habon, Tamas

    2014-12-01

    Capsaicin is a well-known component of red pepper. Recent studies have shown that capsaicin could prevent gastric ulcer provoked by various NSAID-s like acetylsalicylic acid (ASA). Primary objective of this human clinical phase I trial was to investigate whether two different doses of capsaicin co-administered with ASA could alter the inhibitory effect of ASA on platelet aggregation. 15 healthy male subjects were involved in the study and treated orally with 400 μg capsaicin, 800 μg capsaicin, 500 mg ASA, 400 μg capsaicin+500 mg ASA and 800 μg capsaicin+500 mg ASA. Blood was drawn before and 1, 2, 6 and 24 hours after the drug administration. After that epinephrine induced platelet aggregation was measured by optical aggregometry. Between treatments, volunteers had a 6-day wash-out period. Our results showed that capsaicin had no effect on platelet aggregation, while as expected, ASA monotherapy resulted in a significant and clinically effective platelet aggregation inhibition (p ≤ 0.001). The combined ASA-capsaicin therapies reached equivalent effectiveness in platelet aggregation inhibition as ASA monotherapy. Our investigation proved that capsaicin did not influence the inhibitory effect of ASA on platelet aggregation, thus the capsaicin-ASA treatment would combine the antiplatelet effect of ASA with the possible gastroprotection of capsaicin.

  15. A Biomechanical Analysis of the Techniques of Elite Chinese Male Long Jumpers

    Institute of Scientific and Technical Information of China (English)

    郑亦华; 叶永延; 黄敏

    1991-01-01

    The purpose of this paper was to make sport-biomechunical analysis of the techniques of chinese elite male long jumpers. By using the data obtained from the computer processing of the film motion analyzer,authors found that the horizontal velocity of the chinese athltes is higher than that of the foreign athletes.But the vertical velocity , on the contrary ,of the chinese athletes is lower than that of the foreign athletes.This is perhaps the reason why the results of the chinese long jumpers have not been satisfactory.

  16. A low TSH profile predicts olanzapine-induced weight gain and relief by adjunctive topiramate in healthy male volunteers.

    Science.gov (United States)

    Evers, Simon S; van Vliet, André; van Vugt, Barbara; Scheurink, Anton J W; van Dijk, Gertjan

    2016-04-01

    Second generation antipsychotics, like olanzapine (OLZ), have become the first line drug treatment for patients with schizophrenia. However, OLZ treatment is often associated with body weight (BW) gain and metabolic derangements. Therefore, the search for prospective markers for OLZ's negative side effects as well as adjunctive treatments to inhibit these has been of major interest. The aim of this study was to investigate in healthy male volunteers (age: 36 ± 11 years; BW: 84 ± 12 kg; BMI=25.5 ± 2.5) whether adjunctive topiramate (TPM) administration opposes OLZ-induced weight gain over the course of 14 days treatment. In addition, we investigated behavioral, endocrine and metabolic characteristics as underlying and potentially predictive factors for weight regulation and/or metabolic derangements associated with OLZ and TPM treatment. While adjunctive TPM indeed reduced OLZ-induced weight gain (PTPM. Using multiple regression analysis, BW gain was the key factor explaining metabolic disturbances (e.g., plasma insulin- LDL interaction: PTPM treatment, nor its circulating levels, contributed to variation observed in ΔBW. In a second multiple regression analysis, we observed that a low baseline thyrotropin profile (TSHAUC) before the start of drug treatment was associated with an increase in ΔBW over the course of drug treatment (PTPM treatment did attenuate OLZ induced BW gain (PTPM treatment blocking OLZ-induced ΔBW gain. Others have shown that OLZ-induced BW gain is associated with improvement in brief psychiatric rating scores (BPRS); adjunctive TPM treatment may be a solution specifically for those subjects susceptible to OLZ-induced rapid weight gain who-on a therapeutic level-benefit most of OLZ treatment.

  17. SERUM URIC ACID LEVELS OF HEALTHY CAUCASIAN, CHINESE AND HAIDA INDIAN MALES IN BRITISH COLUMBIA.

    Science.gov (United States)

    FORD, D K; DEMOS, A M

    1964-06-06

    Because previous studies have shown that serum uric acid levels are higher in members of the Filipino and Maori races than in Caucasians, and because gout seemed unexpectedly common in the Chinese population of Vancouver, a study of serum uric acid levels in Caucasian, Chinese and Haida Indian males was undertaken. The serum uric acid levels of 200 Caucasian, 100 Chinese and 237 Haida Indian males were determined by the ultraviolet spectrophotometric method of Dubbs, which gives a result 0.5 mg. % below that of the more commonly employed method of Grayzel. The mean level of the Caucasians was 4.55 mg. % and that of the Haida Indians 4.41 mg. %; in contrast, the Chinese mean was 5.44 mg. %, a significantly higher figure than the means of the other two groups. No explanation for this finding can be given at present.

  18. Liquid Chromatography-Electrospray Quadrupole Linear Ion Trap Mass Spectrometric Method for Quantitation of Domperidone in Chinese Healthy Volunteers

    Institute of Scientific and Technical Information of China (English)

    WU Yi; CHU Yang; ZHANG Yun-hui; WU Dan; GU Jing-kai

    2007-01-01

    A rapid, sensitive, and accurate method based on LC/MS/MS was developed and validated for the determination of domperidone in human plasma. Domperidone and internal standard, tramadol, were extracted from plasma with diethyl ether-dichloromethane(60: 40, volume ratio) and separated by reversed-phase HPLC with methanol-water-ammonia solution(80: 20: 0.2, volume ratio) as the mobile phase. Detection was carried out via multiple-reaction monitoring(MRM) on a Q-trapTM LC/MS/MS system(Q-trapTM). The assay result was linear over a concentration range of 0.1-30 ng/mL with a limit of quantitation (LOQ) of 0.1 ng/mL. The inter- and intra-day precision levels were within 7.52% and 12. 9%, respectively, whereas the accuracy was within a range of 87. 3%-114%. This method has been successfully applied to evaluate the pharmacokinetics of domperidone in Chinese healthy volunteers given an oral dose of 10 mg.

  19. Determination of ifenprodil by LC–MS/MS and its application to a pharmacokinetic study in healthy Chinese volunteers

    Directory of Open Access Journals (Sweden)

    Jing Yang

    2013-05-01

    Full Text Available This paper reports the development and validation of an assay for ifenprodil based on liquid chromatography–tandem mass spectrometry (LC–MS/MS and its application to a pharmacokinetic study involving single and multiple intravenous infusions to healthy Chinese volunteers. After sample preparation of plasma by liquid–liquid extraction with ethyl acetate, the analyte and internal standard, urapidil, were separated by reversed phase chromatography in a run time of 4 min and detected by positive ion electrospray ionization followed by multiple reaction monitoring of the precursor-to-product ion transitions at m/z 326.2→308.1 for ifenprodil and m/z 388.4→205.3 for IS. The assay was linear in the concentration range 0.2–50.0 ng/mL with recovery >76.4%. In the pharmacokinetic study of single intravenous infusions of 5, 10 and 15 mg ifenprodil, peak plasma concentrations and areas under the plasma concentration–time curve were both linearly related to dose. In the pharmacokinetic study of multiple once daily intravenous infusions of 10 mg ifenprodil for 7 days, pharmacokinetic parameters were similar to those after the single dose showing that ifenprodil does not accumulate on repeated administration.

  20. Is sexual ornamentation an honest signal of male quality in the Chinese grouse (Tetrastes sewerzowi?

    Directory of Open Access Journals (Sweden)

    Chen Yang

    Full Text Available We examined the variation in sexual ornamentation of male Chinese grouse (Tetrastes sewerzowi in the Gansu Province, China, seeking to identify factors involved in whether ornament size and brightness are honest signals of male quality. Compared to unmated males, mated males had significantly larger and redder combs and, although they did not have significantly larger territories, they defended them more vigorously. Mated males had significantly higher blood carotenoid and testosterone levels, significantly better body condition, and significantly lower parasite loads than unmated males. Our findings are thus consistent with the hypothesis that comb size and color are honest signals of better male quality in the grouse, mediated through lower parasite loads and/or higher testosterone levels.

  1. A replicate designed bioequivalence study to compare two fixed-dose combination products of artesunate and amodiaquine in healthy chinese volunteers.

    Science.gov (United States)

    Liu, Yun; Hu, Chaoying; Liu, Gangyi; Jia, Jingying; Yu, Chen; Zhu, Jianmin; Zheng, Qingsi; Zhang, Kanyin E

    2014-10-01

    Artesun-Plus is a fixed-dose combination antimalarial agent containing artesunate and amodiaquine. The current study was conducted to compare the pharmacokinetic and safety profiles of Artesun-Plus and the WHO-designated comparator product Artesunate Amodiaquine Winthrop. To overcome the high intrasubject variability of artesunate, the study applied a two-sequence and four-period crossover (2 by 4), replicate study design to assess bioequivalence between the two products in 31 healthy male Chinese volunteers under fasting conditions. The results showed that the values of the geometric mean ratios of maximum concentration of drug in plasma (Cmax) and area under the concentration-time curve from time zero to the last blood sample collection (AUC0-last) for the artesunate component in the test and reference products were 95.9% and 93.9%, respectively, and that the corresponding 90% confidence intervals were 84.5% to 108.7% and 87.2% to 101.1%, while the geometric mean ratios for the amodiaquine component in the test and reference products were 95.0% and 100.0%, respectively, and the corresponding 90% confidence intervals were 86.7% to 104.1% and 93.5% to 107.0%. In conclusion, bioequivalence between the two artesunate and amodiaquine fixed-dose combination products was demonstrated for both components. The study also confirmed high intrasubject variability, especially for artesunate: the coefficients of variation (CV) of Cmax values for the test and reference products were 39.2% and 43.7%, respectively, while those for amodiaquine were 30.6% and 30.2%, respectively.

  2. Differences Between Lovastatin and Simvastatin Hydrolysis in Healthy Male and Female Volunteers: Gut Hydrolysis of Lovastatin is Twice that of Simvastatin

    Directory of Open Access Journals (Sweden)

    Tom B. Vree

    2003-01-01

    Full Text Available The aim of this pharmacokinetic evaluation was to show the effect of the extra methyl group in simvastatin on esterase hydrolysis between lovastatin and simvastatin in male and female volunteers. This study was based on the plasma concentration-time curves and the pharmacokinetics of lovastatin and simvastatin with its respective active metabolite statin-β-hydroxy acid obtained from two different bioequivalence studies, each with 18 females and 18 males. Results were: 1-The group of female volunteers showed a higher yield of the active metabolite β-hydroxy acid than the group of males (p < 0.002 for both lovastatin and simvastatin. This difference was not related to the body weight of both groups. 2-In the male/female groups, subject-dependent yield of active metabolite β-hydroxy acid was demonstrated, which was independent of the formulation. The variation in plasma/liver hydrolysis resulted in a fan-shaped distribution of data points when the AUCt lovastatin was plotted vs. that of the β-hydroxy acid metabolite. In the fan of data points, subgroups could be distinguished, each showing a different regression line and with a different Y-intercept (AUCtβ-hydroxy acid. 3-Lovastatin hydrolysis was higher than simvastatin hydrolysis. 4-It was possible to discriminate between hydrolysis of both lovastatin and simvastatin by plasma/liver or tissue esterase activity.

  3. Effects of meta-chlorophenylpiperazine on neuroendocrine and behavioral responses in male schizophrenic patients and normal volunteers.

    Science.gov (United States)

    Maes, M; Meltzer, H Y

    1996-10-16

    Functional alterations in the central serotonergic system, including presynaptic and postsynaptic function, have been reported in schizophrenia. Recently, there have been conflicting reports that the increase in plasma cortisol or prolactin concentrations induced by meta-chlorophenylpiperazine (mCPP) was significantly blunted in schizophrenic patients compared with normal volunteers. Studies of the behavioral effects of mCPP, a serotonin (5-HT) receptor partial agonist with high affinity for 5-HT1C binding sites, have also yielded conflicting results in schizophrenic patients. The purpose of this study was to examine plasma levels of prolactin and cortisol, body temperature, and behavioral responses to mCPP and placebo in a single-blind study in 25 schizophrenic and 15 normal men. No differences either between schizophrenic patients and normal volunteers or between paranoid and undifferentiated/residual subtypes of schizophrenia were found in mCPP-induced prolactin, cortisol, or temperature responses. Schizophrenic patients and normal volunteers reported significant increases in feeling calm and feeling strange of comparable magnitude following mCPP. No significant differences between normal volunteers and schizophrenic patients were found in post-mCPP behavioral ratings, such as anxiety, irritability, depression, restlessness, or arousal.

  4. Hair as an indicator of the body content of polonium in humans: Preliminary results from study of five male volunteers

    DEFF Research Database (Denmark)

    Rääf, C.L.; Holstein, H.; Holm, E.

    2015-01-01

    -consuming radiochemical preparation before alpha spectrometric determination. In order to find a more simple and less labor intensive method hair has been used as a bioindicator and investigated in this study. The relationship between intake and excretion in hair has been estimated in five volunteers who ingested...

  5. Lack of Male-Female Differences in Disposition and Esterase Hydrolysis of Ramipril to Ramiprilat in Healthy Volunteers after a Single Oral Dose

    Directory of Open Access Journals (Sweden)

    Tom B. Vree

    2003-01-01

    Full Text Available The objective of this study was to identify differences in disposition and esterase hydrolysis of ramipril between male and female volunteers. Plasma concentration and area under the concentration-time curve until the last measured concentration (AUCt data of ramipril and its active metabolite ramiprilat (-diacid were obtained from a randomised, cross-over bioequivalence study in 36 subjects (18 females and 18 males. Participants received a single 5-mg oral dose of two different formulations of ramipril (Formulation I and II. Plasma ramipril and ramiprilat concentrations were determined according to validated methods involving liquid chromatography-mass spectrometry. A total number of 2 � 34 available plasma concentration-time curves of both the parent drug and the metabolite could be analysed, and variations (50�100% coefficient of variation [CV] in plasma concentrations of both parent drug and metabolite were found. With both the formulations, the mean plasma concentrations-time curves of males and females were identical. The groups of female and male volunteers showed similar yields (AUCt = mg.h/L of the metabolite ramiprilat (p = 0.37; however, females showed a higher AUCt/kg than males (p = 0.046. This difference was solely attributed to the difference in body weight between males and females (p = 0.00049. In both male and female groups, a subject-dependent yield of active metabolite ramiprilat was demonstrated, which was independent of the formulation.There is a large variation in the ramiprilat t1/2β (50�60% CV. There is a group of subjects who showed a t1/2β of approximately 80 h (15% CV, and two apparent groups with a longer t1/2βfor each formulation (124 h, 22.5% CV; 166 h, 21.6% CV, respectively, p = 0.0013. This variation in the terminal half-life of ramiprilat is not sex related. In all three groups of half-lives, the corresponding Cmax values (mean � SD of ramiprilat in males and females were identical. Thus, with

  6. The Area of Secondary Hyperalgesia following Heat Stimulation in Healthy Male Volunteers: Inter- and Intra-Individual Variance and Reproducibility.

    Directory of Open Access Journals (Sweden)

    Morten Sejer Hansen

    Full Text Available Clinical pain models can be applied when investigating basic physiologic pain responses in healthy volunteers. Several pain models exist; however, only few have been adequately validated. Our primary aim with this prospective study was to investigate the intra- and inter-individual variation in secondary hyperalgesia elicited by brief thermal sensitization (45°C for 3 min in healthy volunteers.Fifty healthy volunteers were included. Areas of secondary hyperalgesia following brief thermal sensitization were investigated by 2 observers on 4 experimental days, with a minimum interval of 7 days. Additionally, heat pain detection threshold and pain during thermal stimulation (45°C for 1 min., and the psychological tests Pain Catastrophizing Scale and Hospital Anxiety and Depression Score were applied.For areas of secondary hyperalgesia, an intra-observer intra-person correlation of 0.85, 95% CI [0.78, 0.90], an intra-observer inter-person correlation of 0.03, 95% CI [0.00, 0.16], and a coefficient of variation of 0.17, 95% CI [0.14, 0.21] was demonstrated. Four percent of the study population had areas of secondary hyperalgesia both below the 1st and above the 3rd quartile considering all included participants. Heat pain detection threshold predicted area of secondary hyperalgesia with an adjusted R2 of 0.20 (P = 0.0006.We have demonstrated a low intra-individual, and a high inter-individual variation in thermally induced secondary hyperalgesia. We conclude that brief thermal sensitization produce secondary hyperalgesia with a high level of reproducibility, which can be applied to investigate different phenotypes related to secondary hyperalgesia in healthy volunteers.clinicaltrials.gov NCT02166164.

  7. Ethnic differences in body composition and obesity related risk factors: study in Chinese and white males living in China.

    Directory of Open Access Journals (Sweden)

    Dong Wang

    Full Text Available The purpose of this cross-sectional observational study was to identify ethnic differences in body composition and obesity-related risk factors between Chinese and white males living in China. 115 Chinese and 114 white male pilots aged 28-63 years were recruited. Fasting body weight, height and blood pressure were measured following standard procedures. Whole-body and segmental body composition were measured using an 8-contact electrode bioimpedance analysis (BIA system. Fasting serum glucose, fasting plasma total cholesterol (TC, high-density lipoprotein (HDL cholesterol, and triglycerides (TG were assessed using automatic biochemistry analyzer. After adjusting for age and body mass index (BMI, Chinese males had significantly higher percentage of body fat (PBF both with respect to whole body (Chinese: 23.7%±0.2% vs. Whites: 22.4%±0.2% and the trunk area (Chinese: 25.0%±0.3% vs. Whites: 23.2%±0.3% compared to their white counterparts. At all BMIs, Chinese males had significantly higher fasting glucose levels (Chinese: 5.7±1.0 mmol/L vs. Whites: 5.2±1.0 mmol/L but lower high-density lipoprotein levels (Chinese: 0.8±1.0 mmol/L vs. Whites: 1.0±1.0 mmol/L than white males. In addition, a marginally significantly higher diastolic blood pressure was found among Chinese men than that among white men (Chinese: 80±1.0 mmHg vs. Whites: 77±1.0 mmHg. Chinese males had more body fat and a greater degree of central fat deposition pattern than that seen in white males in the present study. Furthermore, data on blood pressure, fasting glucose and blood lipids suggest that Chinese men may be more prone to obesity-related risk factors than white men.

  8. High risk genetic factor in Chinese patients with idiopathic male infertility:deletion of DAZ gene copy on Y chromosome

    Institute of Scientific and Technical Information of China (English)

    杨元; 肖翠英; 张思仲; 张思孝; 黄明孔; 林立

    2004-01-01

    @@ Idiopathic azoospermia or oligozoospermia affects approximately 2%-4% of all married males. Recently studies have confirmed that the deletion of DAZ in AZFc region of Y chromosome may be one of the important genetic aetiologies of Caucasian male infertility. To determine the relationship between DAZ gene deletion and idiopathic male infertility in Chinese population, we analysed the DAZ gene copy number of AZFc region in patients with idiopathic azoospermia or oligozoospermia, as well as fertile Chinese men.

  9. Efficacy of FurosapTM, a novel Trigonella foenum-graecum seed extract, in Enhancing Testosterone Level and Improving Sperm Profile in Male Volunteers

    Science.gov (United States)

    Maheshwari, Anuj; Verma, Narsingh; Swaroop, Anand; Bagchi, Manashi; Preuss, Harry G.; Tiwari, Kiran; Bagchi, Debasis

    2017-01-01

    Background: Dietary fiber rich fenugreek (Trigonella foenum-graecum) seeds have exhibited cardioprotective, hypolipidemic and other health benefits. Furosap (FS), an innovative, patented, 20% protodioscin-enriched extract was developed in our laboratory from fenugreek seeds. This study examined the free and total testosterone levels, sperm profile and morphology, sexual health, mood and mental alertness, and broad spectrum safety parameters of FS in 50 male volunteers following supplementation over a period of 12 weeks. Methods: Institutional Review Board (IRB) and other regulatory approvals were obtained for our study. This one-arm, open-labelled, multi-center study was conducted in 50 male volunteers (age: 35 to 65 years) over a period of 12 weeks to determine the efficacy of FS (500 mg/day/subject) on free and total testosterone levels, sperm profile, sperm morphology, libido and sexual health, mood and mental alertness, and broad spectrum safety parameters. Results: Free testosterone levels were improved up to 46% in 90% of the study population. 85.4% of the study population showed improvements in sperm counts. Sperm morphology improved in 14.6% of volunteers. Majority of the subjects enrolled in the study demonstrated improvements in mental alertness and mood. Furthermore, cardiovascular health and libido were significantly improved. Extensive safety parameters were evaluated which included blood chemistry data. No significant changes were observed in serum lipid function, cholesterol, triglyceride, HDL and LDL levels, hemogram (CBC), hepatotoxicity and nephrotoxicity. Conclusion: Overall, the results demonstrate that FS, enriched in 20% protodioscin, is safe and effective in attenuating testosterone levels, healthy sperm profile, mental alertness, cardiovascular health and overall performance in human subjects. PMID:28138310

  10. Histological Subtypes of Lung Cancer in Chinese Males from 2000 to 2012

    Institute of Scientific and Technical Information of China (English)

    ZOU Xiao Nong; LIN Dong Mei; WAN Xia; CHAO Ann; FENG Qin Fu; DAI Zhen; YANG Gong Huan; LV Ning

    2014-01-01

    Objective To characterize the histological and epidemiological features of male lung cancer patients in China. Methods The demographic and histological information about male lung cancer patients identified from 2000-01-01 to 2012-12-31, was collected from the Cancer Hospital of the Chinese Academy of Medical Sciences. Relative frequencies (RF) were estimated for major histological subtypes and compared according to the years of diagnosis and birth. Results The RF of adenocarcinoma (ADC) increased from 21.96% to 43.36% and the RF of squamous cell carcinoma (SCC) decreased from 39.11% to 32.23% from 2000 to 2012 in the 15 427 male lung cancer patients included in this study (Z=17.909, P Conclusion The increased RF of ADC in male lung cancer patients highlights the need for further investigation of the etiologic factors of these tumors. Smoke-free policies rather than modifying tobacco products should be enforced.

  11. Effects of Red Palm Oil on Serum Lipids and Plasma Carotenoids Level in Chinese Male Adults

    Institute of Scientific and Technical Information of China (English)

    JIAN ZHANG; CHUN-RONG WANG; AN-NA XUE; KE-YOU GE

    2003-01-01

    Objective Effects of red palm oil on major plasma carotenoids, tocopherol, retinol and serumlipids were evaluated when used in Chinese diet. Methods Red palm oil group (RPO) composed of 20 male subjects(aged 18-32) and soybean oil group (SBO) composed of 22 male subjects (aged18-32). Dietary fat provided about 28% of total calories, and the test oil accounted for about 60% of total dietary fat. In the 3 weeks of pretest period, diets were prepared with soybean oil, and then in the next 6 weeks subjects in each group consumed the diet prepared by test oil. Results Plasmaα-carotene, β-carotene and lycopene concentration of RPO group significantly increased at the time of interim (21 days) and of the end (42 days) (P<0.05), and α-tocopherol concentration significantly increased at the time of the end (42 days) in this study. Though Chinese plasma retinol level was relatively low when compared with that of Westerners, red palm oil diet showed no significant effect on adult Chinese plasma retinol level. Serum concentration of total cholesterol, triglyceride, high density lipoprotein cholesterol, apolipoprotein AI and apolipoprotein B of all subjects showed no significant changes in RPO group during the study. Conclusions The data in our study suggest that red palm oil is a good source of carotenoids and vitamin E when used in Chinese diet preparation, and it can significantly increase plasma concentration of α-carotene, β-carotene, lycopene andα-tocopherol.

  12. A high-carbohydrate diet lowered blood pressure in healthy Chinese male adolescents.

    Science.gov (United States)

    Zhu, Xingchun; Lin, Jia; Song, Yongyan; Liu, Hui; Zhang, Rongrong; Fan, Mei; Li, Yuanhao; Tian, Rong; Fang, Dingzhi

    2014-04-01

    Different diets consumed by individuals of different ethnicities, gender, and age may cause changes in blood pressure. The current study sought to investigate changes in blood pressures after consumption of a high-carbohydrate (high-CHO) diet by healthy Chinese adolescents. As a population, the Chinese consume a diet with a high carbohydrate content and they have a low incidence of hypertension and coronary artery disease. Dietary data were collected using a 3-day diet diary. Subjects were 672 high school students who were divided into a high-CHO diet group (≥ 55% carbohydrates) and a non-high-CHO diet group (blood pressure (SBP), and diastolic blood pressure (DBP) were measured. Body mass index (BMI), waist-to-hip ratio (WHR), pulse pressure (PP), and mean arterial pressure (MAP) were calculated. Results indicated that males had a higher BMI, glucose level, SBP, DBP, PP, and MAP than females. When diet was taken into account, males in the non-high-CHO diet group had a higher SBP and PP than females. Males in the high-CHO diet group had a higher glucose level than females. Males in the high-CHO diet group had a lower SBP (p = 0.004) and PP (p = 0.002) than males in the non-high-CHO diet group and females in the high-CHO diet group had a lower glucose level (p = 0.003) than females in the non-high-CHO diet group. After adjusting for age, BMI, WHR, heart rate, the total daily energy intake, and the intake of vitamin C, calcium, sodium, potassium and magnesium, significant differences in SBP and PP were noted in males. These results indicate that male adolescents consuming a high-CHO diet had a lower SBP and PP than males consuming a non-high-CHO diet.

  13. 泛昔洛韦片在中国健康人体的生物等效性%Bioequivalence of famciclovir tablets in Chinese healthy volunteers

    Institute of Scientific and Technical Information of China (English)

    郭韶洁; 王淑民; 武峰; 李嘉静; 周辉; 赵秀丽

    2012-01-01

    目的 评价2种国产泛昔洛韦片在中国健康人体的生物等效性.方法 20名健康男性受试者随机交叉单剂量口服泛昔洛韦片试验药物或对照药物,各500 mg.用高效液相色谱法测定血浆中喷昔洛韦浓度;用DAS 2.0软件计算药代动力学参数,并对2种药物进行生物等效性评价.结果 试验药物和对照药物的药代动力学参数:Cmax分别为(2.60±0.53)和(3.50 ±0.84)mg·L-1;Tmax 分别为(0.99±0.45)和(2.50±0.23)h;t1/2分别为(2.52±0.32)和(2.50±0.23);AUC0-t分别为(9.10±1.61)和(9.61±1.70)mg·h·L-1.AUC0-t、AUC0-∞、Cmax的90%可信区间分别为90.7%~ 99.0%、90.9%~99.6%和70.4%~ 80.6%.试验药物相对于对照药物的生物利用度F为(95.29±9.85)%.结论 试验药物和对照药物生物等效.%Objective To evaluate the bioequivalent of test tablet and reference tablet of famciclovir in Chinese volunteers. Method In self -control and two - way crossover design, 20 healthy male volunteers were divided into two groups at random. Each subject was given 500 mg of the test tablet and reference tablet of famciclovir respectively at single dose. Plasma concentrations of penciclovir ( active metabolin) were determined by HPLC method. The pharmacokinetic parameters were calculated with DAS statistic software, the bioequivalent of famciclovir tablet evaluated as well. Results The main pharmacokinetic parameters of famciclovir test tablet and reference tablet were as follows: C^ ( 2. 60 ± 0. 53 ) , ( 3. 50 ±0.84) mg·L-1; Tmax,(0. 99 ±0.45), (2.50±0.23) h ; t1/2(2.52 ±0.32),(2. 50 ±0. 23) h; AUC0_t(9. 10 ±1.61), (9.61 ±1.70)mg ? H ? L~ , respectively. The relative bioavailability of famciclovir test tablet was (95. 29 ± 9. 85)% . Conclusion The test tablet and reference tablet of famciclovir were bioequivalent.

  14. 盐酸托莫西汀胶囊的人体生物等效性%Study on bioequivalence of atomoxetine hydrochloride capsules in Chinese healthy volunteers

    Institute of Scientific and Technical Information of China (English)

    李国成; 陈楚雄; 林建荣; 温预关

    2011-01-01

    OBJECTIVE To study the bioequivalence of atomoxetine hydrochloride capsules in Chinese healthy volunteers.METHODS 20 mg test preparation and reference preparation were given to 20 male healthy volunteers in randomized two-way crossover design for the pharmacokinetic and relative bioavailability study.Plasma concentrations of atomoxetine were determined by HPLC-MS/MS.RESULTS The main pharmacokinetic parameters of the two preparation were: Cmax (257.1 ± 57.8) μg· L-1 and(260.6 ± 51.6)μg·L-1 ,tmax(1.6 0.9)h and (1.5 ± 1.0) h,t1/2 (3.5 ± 1.3)h and (3.3 ± 1.2)h, AUC0-24 (939.8 ± 179.2) μg · L - 1 · h and (983.6 ± 177.3 ) μg · L - 1 · h, AUC0-∞ (965.2 ± 174.8) μg · L - 1 · h and ( 993.8 ± 170.5 ) μg · L - 1 · h respectively.The mean relative bioavailability of test preparation vs reference preparation were (95.6 ± 16.9)%.CONCLUSION The statistical analysis shows the two prparations are bioequivalent.%目的:研究国产盐酸托莫西汀胶囊的人体生物等效性.方法:20名健康男性志愿者按2×2交叉试验方案设计,分别口服受试制剂和参比制剂各20 mg,并采集24 h内动态血标本;用HPLC-MS-MS法测定血浆中托莫西汀浓度,计算药动学参数,并判定2种制剂的生物等效性.结果:受试制剂和参比制剂的主要药动学参数Cmax分别为(257.1±57.8)μg·L-1和(260.6±51.6)μg·L-1,tmax分别为(1.6±0.9)h和(1.5±1.0)h,t1/2分别为(3.5±1.3)h和(3.3±1.2)h,AUC0-24分别为(939.8±179.2)μg·L-1·h和(983.6±177.3)μg·L-1·h,AUC0-∞分别为(965.2±174.8)μg·L-1·h和(993.8±170.5)μg·L-1·h,2种制剂主要药动学参数经对数转换后进行方差分析及双单侧t检验,并计算90%置信区间,表明2种制剂生物等效,受试制剂的人体生物利用度为(95.6±16.9)%.结论:2种制剂生物等效.

  15. 吡喹酮片的人体生物等效性%Study on bioequivalence of praziquantel tablets in Chinese healthy volunteers

    Institute of Scientific and Technical Information of China (English)

    李国成; 刘春霞; 伍俊研; 温预关

    2011-01-01

    OBJECTIVE To study the bioequivalence of praziquantel tablets in Chinese healthy volunteers. METHODS 1 g test preparation and reference preparation were given to 20 male healthy volunteers in randomized two-way crossover design for the pharmacokinetic and relative bioavailability study. Plasma concentrations of praziquantel were determined by HPLC-MS/MS. RESULTS The main pharmacokinetie parameters of the two preparation were:Cmax(253.7± 77. 9)μg· L-1 and (250. 6 ±71.6)μg·L-1,tmax(0.93 ±0.23)h and (0.94±0. 23)h,t1/2(2.9± 1.1)h and (2.3±0. 7)h, AUC0-10(644.4± 244.9)μg·L-1 ·h and (709. 7 ± 270. 0 )μg·L-1·h, AUC0-∞ (723. 4± 267. 6 ) μg · L - 1 · h and ( 753. 4 ± 284. 5 ) μg· L - 1 · μg·L - 1·h respect ively. The mean relative bioavailability of test preparation vs reference preparation were (95. 9 ± 15. 8) %. CONCLUSION The statistical analysis shows that the two prparations are bioequivalent.%目的:研究国产吡喹酮片的人体生物等效性.方法:20名健康男性志愿者按2×2交叉试验方案设计,分别口服受试制剂和参比制剂各1g,并采集10h内动态血标本;用HPLC-MS/MS法测定血浆中吡喹酮浓度,计算药动学参数,并判定两种制剂的生物等效性.结果:受试制剂和参比制剂的主要药动学参数Cmax分别为(253.7±77.9)μg·L-1和(250.6±71.6)μg·L-1,tmax分别1为(0.9±0.2)h和(0.9±0.2)h,t1/2=分别为(2.±1.1)h和(2.3±0.7)h.AUC0-10分别为(644.4±244.9)μg·L-1·h和(709.7±270.0)μg·L-1·h,AUC0-∞分别为(723.4±267.6)μg·L-1·h和(753.4±284.5)μg·L-1·h,两制剂主要药动学参数经对数转换后进行方差分析及双单侧t检验,并计算90%置信区间,表明两种制剂生物等效,受试制剂的人体生物利用度为(95.9±15.8)%.结论:两种制剂生物等效.

  16. Pharmacokinetics of leflunomide in Chinese healthy volunteers%来氟米特在中国健康志愿者的药代动力学

    Institute of Scientific and Technical Information of China (English)

    李俊; 姚宏伟; 金涌; 张运芳; 李常玉; 李元海; 徐叔云

    2002-01-01

    目的:研究来氟米特在中国健康志愿者的药代动力学.方法:18名健康志愿者随机分为三组,分别单剂量口服来氟米特(20,40,60mg);6名健康志愿者多剂量口服来氟米特20 mg/d,连续30 d.高效液相色谱法检测来氟米特活性代谢物(A77126).结果:A771726的血药浓度变化符合一级吸收的一房室模型.单剂量口服来氟米特(20,40,60mg)的主要药动学参数为:T1/2,ke(h):211±18,170±24,252±26;Tmax(h):13±12,13±4,9±5;Cmax(mg/L):2.0±0.5,5.2±0.6,6.7±1.5;AUC(mg@h@L-1):647±137,1344±191,2555±907.口服来氟米特20 mg@d-1,连续30 d,血药浓度达到稳态水平.平均谷浓度为32.01-39.72 mg/L.Cmax,Tmax和AUC0-24分别为(41.5±2.4)mg/L,(307±75)h和(22099±1234)mg@h@L-1.结论:本品口服吸收快,消除慢.口服20 mg@d-1,连续30 d,血药浓度达到稳态水平.在所试剂量范围内,A771726的血药浓度变化符合一级吸收的一房室模型.%AIM: To study the pharmacokinetics of leflunomide in Chinese healthy volunteers. METHODS: A single (20, 40, and 60 mg) and 30-d-repeated (20 mg/d) oral doses of leflunomide were performed on 18 (12 males and 6 females) and 6 ( 4 males and 2 females) Chinese healthy volunteers respectively. A771726, the active metabolite of leflunomide, in serum was determined by high performance liquid chromatography (HPLC). Data were analyzed by a 3p97 program on a Legend computer.RESULTS: Serum concentration curves of A771726 in single and repeated oral administration of leflunomide conformed to one compartment model of the first order absorption. Leflunomide was absorbed rapidly with T1 2.ka of between 1.15 h and 2.23 h in single oral administration. The major pharmacokinetic parameters of A771726 in 20, 40, and 60 mg groups were T1/2,ke(h):211± 18, 170 ± 24, 252 ± 26; Tmax(h): 13 ± 12,13±4, 9±5; Cmax(mg/L): 2.0±0.5, 5.2±0.6,6.7±1.5; AUC (mg@h@L-1): 647±137, 1344±191,2555 ± 907, respectively. In repeated oral administration, steady state

  17. The effect of acute exogenous melatonin on P50 suppression in healthy male volunteers stratified for low and high gating levels

    DEFF Research Database (Denmark)

    Ucar, Ebru; Lehtinen, Emilia K; Glenthøj, Birte Y

    2012-01-01

    Sensory gating is frequently found to be disturbed in patients with schizophrenia. In addition, a disruption of the circadian rhythm together with a low nocturnal melatonin output is regularly found in these patients. Since there is some evidence that a brief period of sleep normalizes sensory...... gating in schizophrenia patients, it is conceivable that their disrupted melatonin level may contribute to the deficits in P50 suppression. In this initial study, the effects of acutely administered melatonin on sensory gating in healthy subjects were investigated. In a double-blind placebo......-controlled crossover design, 21 healthy male volunteers were administered melatonin (4 mg) or placebo, after which they were tested in a P50 suppression paradigm. In the group as a whole, melatonin did not affect P50 suppression. However, melatonin increased the P50 ratio in the individuals with high baseline...

  18. Cytological Observation of Microsporogenesis in Male-Sterile Lines of Chinese Pink (Dianthus chinensis L.)

    Institute of Scientific and Technical Information of China (English)

    FU Xiao-peng; HU Jin-yi; HU Hui-rong; BAO Man-zhu

    2008-01-01

    This study addressed the differences in microsporogenesis between male sterile and fertile lines of Chinese pink. The microsporogenesis processes of male sterile and fertile lines were histologically examined in squashed pollen grains and in paraffin embedded sections. A stable male-sterile line (H-37B) was obtained following six generations of inbreeding in a self-fertile line, followed by two generations of backcrossing. In the corresponding fertile line, development of the mature pollen grains was followed through the initiation of the sporogenous cell, microsporocyte formation, and the tetrad developmental period. In the male-sterile line, abortion of the developing pollen grains was observed to take place at various stages, namely, sporogenous cell growth, mother cell meiosis, and tetrad transformation to the uninuclear state. The pollen grains of the fertile line were spheroid, turgid, and viable. By contrast, the male-sterile line produced pollen that was irregular in shape, empty, and nonviable. The abortion of the microspore in the male-sterile line appeared to relate to abnormal growth of the tapetum layer.

  19. Catechol-O-methyltransferase val158met genotype determines effect of reboxetine on emotional memory in healthy male volunteers

    Science.gov (United States)

    Gibbs, Ayana A.; Bautista, Carla E.; Mowlem, Florence D.; Naudts, Kris H.; Duka, Dora T.

    2014-01-01

    Background Catechol-O-methyltransferase (COMT) metabolizes catecholamines in the prefrontal cortex (PFC). A common polymorphism in the COMT gene (COMT val158met) has pleiotropic effects on cognitive and emotional processing. The met allele has been associated with enhanced cognitive processing but impaired emotional processing relative to the val allele. Methods We genotyped healthy, white men in relation to the COMT val158met polymorphism. They were given a single 4 mg dose of the selective noradrenaline reuptake inhibitor (NRI) reboxetine or placebo in a randomized, double-blind between-subjects model and then completed an emotional memory task 2 hours later. Results We included 75 men in the study; 41 received reboxetine and 34 received placebo. In the placebo group, met/met carriers did not demonstrate the usual memory advantage for emotional stimuli that was observed in val carriers. Reboxetine restored this emotional enhancement of memory in met/met carriers, but had no significant effect in val carriers. Limitations We studied only men, thus limiting the generalizability of our findings. We also relied on self-reported responses to screening questions to establish healthy volunteer status, and in spite of the double-blind design, participants were significantly better than chance at identifying their intervention allocation. Conclusion Emotional memory is impaired in healthy met homozygotes and selectively improved in this group by reboxetine. This has potential translational implications for the use of reboxetine, which is currently licensed as an antidepressant in several countries, and edivoxetine, a new selective NRI currently in development. PMID:24467942

  20. An association study of HFE gene mutation with idiopathic male infertility in the Chinese Han population

    Institute of Scientific and Technical Information of China (English)

    Xiao-Ying Yu; Xu Ma; Bin-Bin Wang; Zhong-Cheng Xin; Tao Liu; Ke Ma; Jian Jiang; Xiang Fang; Li-Hua Yu; Yi-Feng Peng

    2012-01-01

    Mutations in the haemochromatosis gene (HFE) influence iron status in the general population of Northern Europe,and excess iron is associated with the impairment of spermatogenesis.The aim of this study is to investigate the association between three mutations (C282Y,H63D and S65C) in the HFE gene with idiopathic male infertility in the Chinese Han population.Two groups of Chinese men were recruited:444 infertile men (including 169 with idiopathic azoospermia) and 423 controls with proven fertility.The HFEgene was detected using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.The experimental results demonstrated that no C282Y or S65C mutations were detected.Idiopathic male infertility was not significantly associated with heterozygous H63D mutation (odds ratio=0.801,95% confidence interval=0.452-1.421,X2=0.577,P=0.448).The H63D mutation frequency did not correlate significantly with the serum luteinizing hormone (LH),follicle-stimulating hormone (FSH) and testosterone (T) levels in infertile men (P=0.896,P=0.404 and P=0.05,respectively).Our data suggest that the HFE H63D mutation is not associated with idiopathic male reproductive dysfunction.

  1. Association of nicotinic acetylcholine receptor subunit alpha-4 polymorphisms with smoking behaviors in Chinese male smokers

    Institute of Scientific and Technical Information of China (English)

    CHU Cheng-jing; YANG Yan-chun; WEI Jin-xue; ZHANG Lan

    2011-01-01

    Background It has been reported that the nicotinic acetylcholine receptor subunit a4 gene (CHRNA4) might be associated with smoking behaviors in the previous studies. Up to now, there are few reports on the relationship between CHRNA4 and smoking initiation. In this study, we tried to explore the role of two polymorphisms in CHRNA4 (rs 1044396 and rs 1044397) in smoking initiation and nicotine dependence in Chinese male smokers.Methods Nine hundred and sixty-six Chinese male lifetime nonsmokers and smokers were assessed by the Fagerstr(o)m test for nicotine dependence (FTND), smoking quantity (SQ) and the heaviness of smoking index (HSI). All subjects were divided into four groups based on their tobacco use history and the FTND scores. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed to find two polymorphisms of CHRNA4 in these subjects.Results The x2 test showed that rs1044396 was significantly associated with smoking initiation (x2=4.65, P=0.031),while both rs1044396 and rs1044397 were significantly associated with nicotine dependence (x2=5.42, P=0.020; x2=758,P=0.005). Furthermore, the T-G (3.9%) haplotype of rs1044396-rs1044397 showed significant association with smoking initiation (x2=6.30, P=0.012) and the C-G haplotype (58.9%) remained positive association with nicotine dependence (x2=8.64, P=0.003) after Bonferroni correction. The C-G haplotype also significantly increased the HSI (P=0.002) and FTND scores (P=0.001) after Bonferroni correction.Conclusion These findings suggest that CHRNA4 may be associated with smoking initiation and the C-G haplotype of rs1044396-rs1044397 might increase the vulnerability to nicotine dependence in Chinese male smokers.

  2. New oxygenated himachalenes in male-specific odor of the Chinese windmill butterfly, Byasa alcinous alcinous.

    Science.gov (United States)

    Ômura, Hisashi; Noguchi, Taro; Nehira, Tatsuo

    2016-01-01

    Male adults of the Chinese windmill Byasa alcinous alcinous (Papilionidae) are well known to have a strong musk-like odor, in which two oxygenated himachalene compounds, together with six sesquiterpene hydrocarbons, were newly discovered. γ-Himachalen-4-yl acetate (1) was the predominant compound isolated from the solvent extract of the males. The structure of 1 was determined using MS and NMR, and its relative configuration was established as 1S*,4R*,6R* by NOE analysis with the help of quantum mechanical computation. Interestingly, the amount of 1 in males increased until 7 days after eclosion, suggesting that this compound is involved in sexual maturation for mating. Another new compound was identified as γ-himachalen-4-ol (2) by comparison with the retention time and mass spectrum of the hydrolysate of 1. Since males of other papilionid species have general volatiles omnipresent in plants and insects, the presence of species-specific volatiles in males is characteristic of B. alcinous alcinous.

  3. Growth hormone (GH) activity is associated with increased serum oestradiol and reduced Anti-Müllerian Hormone in healthy male volunteers treated with GH and a GH antagonist

    DEFF Research Database (Denmark)

    Andreassen, M; Frystyk, Jan; Faber, J;

    2013-01-01

    Growth hormone (GH) and insulin-like growth factor I (IGF-I) receptors are present on pituitary gonadotrophs and on testicular Leydig and Sertoli cells. Thus, the GH/IGF-I system may modulate the pituitary-gonadal axis in males. This is a randomized cross-over study. Eight healthy male volunteers...... (mean age 35, range 29-46 years) were treated with GH for 3 weeks (1st week 0.01, 2nd week 0.02, 3rd week 0.03 mg/day/kg) or a GH receptor antagonist (Pegvisomant) (1st week 10, last 2 weeks 15 mg/day), separated by 8 weeks of washout. Before and after the two treatment periods, concentrations...... of luteinizing hormone (LH), follicle-stimulating hormone, testosterone, oestradiol, sex hormone-binding globulin, inhibin B and Anti-Müllerian Hormone (AMH) were measured. During GH treatment, IGF-I increased [(median (IQR)] 166 (162-235) vs. 702 (572-875) μg/L, p

  4. Cognitive behavioral therapy to reduce overt aggression behavior in Chinese young male violent offenders.

    Science.gov (United States)

    Chen, Chen; Li, Chun; Wang, Hong; Ou, Jian-Jun; Zhou, Jian-Song; Wang, Xiao-Ping

    2014-01-01

    This 9-week study was designed to determine whether a commercial cognitive-behavioral training program could effectively reduce overt aggression behavior in Chinese young male violent offenders. Sixty-six participants were randomly assigned to receive routine intervention alone (control group) or routine intervention plus Williams LifeSkills Training (WLST group) in a 1:1 ratio. The primary outcome was change scores on the Modified Overt Aggression Scale (MOAS) from baseline to one week following end of training. Secondary outcomes were change scores on the Barratt Impulsiveness Scale-11 (BIS-11) and Cook-Medley Hostility Scale (CMHS). There were significant between-group differences in change of MOAS total score (P young male violent offenders.

  5. Sensitive and Rapid Quantification of Felodipine by High-performance Liquid Chromatography-tandem Mass Spectrometry(HPLC-MS/MS) and Its Pharmacokinetics in Healthy Chinese Volunteers

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    To investigate the pharmacokinetics of felodipine in the plasma of healthy Chinese volunteers, 30 healthy volunteers received a single oral dose of 5 mg of extended release felodipine tablets. The felodipine was extracted from the matrix with a liquid-liquid extract procedure and analyzed by high-performance liquid chromatography-tandem mass spectrometry in the multiple reaction monitoring(MRM) mode using an electrospray ion source with positive ion detection. The method was validated over a felodipine concentration range of 0.05-10.00 ng/mL in human plasma. Its main pharmacokinetic parameters values were: ρmax=(1.67±0.84) ng/mL, occurring at (3.93±2.49) h; the plasma elimination half-life: (23.08±9.48) h and the area under the plasma concentration versus time curve: (29.94±14.39) ng·h/mL. The validation results demonstrated that this method showed a satisfactory precision and accuracy across the calibration range. The procedure involved minimal drug administration, sample preparation, and a 2.5-min chromatographic run time. It was well suited to clinical studies of the drug involving large numbers of samples.

  6. Short-term sleep deprivation with nocturnal light exposure alters time-dependent glucagon-like peptide-1 and insulin secretion in male volunteers.

    Science.gov (United States)

    Gil-Lozano, Manuel; Hunter, Paola M; Behan, Lucy-Ann; Gladanac, Bojana; Casper, Robert F; Brubaker, Patricia L

    2016-01-01

    The intestinal L cell is the principal source of glucagon-like peptide-1 (GLP-1), a major determinant of insulin release. Because GLP-1 secretion is regulated in a circadian manner in rodents, we investigated whether the activity of the human L cell is also time sensitive. Rhythmic fluctuations in the mRNA levels of canonical clock genes were found in the human NCI-H716 L cell model, which also showed a time-dependent pattern in their response to well-established secretagogues. A diurnal variation in GLP-1 responses to identical meals (850 kcal), served 12 h apart in the normal dark (2300) and light (1100) periods, was also observed in male volunteers maintained under standard sleep and light conditions. These findings suggest the existence of a daily pattern of activity in the human L cell. Moreover, we separately tested the short-term effects of sleep deprivation and nocturnal light exposure on basal and postprandial GLP-1, insulin, and glucose levels in the same volunteers. Sleep deprivation with nocturnal light exposure disrupted the melatonin and cortisol profiles and increased insulin resistance. Moreover, it also induced profound derangements in GLP-1 and insulin responses such that postprandial GLP-1 and insulin levels were markedly elevated and the normal variation in GLP-1 responses was abrogated. These alterations were not observed in sleep-deprived participants maintained under dark conditions, indicating a direct effect of light on the mechanisms that regulate glucose homeostasis. Accordingly, the metabolic abnormalities known to occur in shift workers may be related to the effects of irregular light-dark cycles on these glucoregulatory pathways.

  7. Pharmacokinetic interaction between udenafil and dapoxetine: a randomized, open-labeled crossover study in healthy male volunteers

    Directory of Open Access Journals (Sweden)

    Kim YH

    2015-02-01

    Full Text Available Yo Han Kim,1 Hee Youn Choi,1 Shi Hyang Lee,1 Hae Sun Jeon,1 Hyeong-Seok Lim,1 Mi Young Bahng,2 Kyun-Seop Bae1 1Department of Clinical Pharmacology and Therapeutics, Asan Medical Center, College of Medicine, University of Ulsan, 2Clinical Development Department, Dong-A ST Co, Ltd, Seoul, Republic of Korea Background: “Udenafil” is a phosphodiesterase-5 inhibitor indicated for erectile dysfunction. “Dapoxetine” is a serotonin transport inhibitor indicated for premature ejaculation. The aim of the study reported here was to investigate the pharmacokinetic drug interaction between udenafil and dapoxetine in healthy male subjects. Methods: An open-label, three-treatment, six-sequence, three-period crossover study was performed in healthy male subjects. In varying sequences, each subjects received single oral doses of udenafil 200 mg, dapoxetine 60 mg, and both treatments. The periods were separated by a washout period of 7 days. Serial blood samples were collected up to 48 hours after dosing. The plasma concentrations of udenafil and dapoxetine were determined using a validated liquid chromatography-tandem mass spectrometry method. Pharmacokinetic parameters were obtained by non-compartmental analysis. Tolerability was assessed throughout the study. Results: Twenty-three healthy subjects completed the study. The geometric mean ratios of the area under the plasma concentration–time curve from time 0 to last measurable time point and measured peak plasma concentration for udenafil were 0.923 (90% confidence interval [CI]: 0.863–0.987 and 0.864 (90% CI: 0.789–0.947, respectively. The geometric mean ratios of the area under the plasma concentration–time curve from time 0 to last measurable time point and measured peak plasma concentration for dapoxetine were 1.125 (90% CI: 1.044–1.213 and 0.837 (90% CI: 0.758–0.925, respectively. There were no serious adverse events reported, and none of the subjects dropped out due to adverse events

  8. Single whole-body cryostimulation procedure versus single dry sauna bath: comparison of oxidative impact on healthy male volunteers.

    Science.gov (United States)

    Sutkowy, Paweł; Woźniak, Alina; Rajewski, Paweł

    2015-01-01

    Exposure to extreme heat and cold is one of the environmental factors whose action is precisely based on the mechanisms involving free radicals. Fluctuations in ambient temperature are among the agents that toughen the human organism. The goal of the study was to evaluate the impact of extremely high (dry sauna, DS) and low (whole-body cryostimulation, WBC) environmental temperatures on the oxidant-antioxidant equilibrium in the blood of healthy male subjects. The subjects performed a single DS bath (n = 10; 26.2 ± 4.6 years) and a single WBC procedure (n = 15; 27.5 ± 3.1 years). In the subjects' blood taken immediately before and 20 min after the interventions, the activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) and the concentration of thiobarbituric acid reactive substances in erythrocytes (TBARSer) and blood plasma (TBARSpl) were determined. Single WBC and DS procedures induced an increase in the activity of SOD and GPx, as well as SOD and CAT, respectively. The SOD activity was higher after WBC than after DS. Extremely high and low temperatures probably induce the formation of reactive oxygen species in the organisms of healthy men and, therefore, disturb the oxidant-antioxidant balance.

  9. Single Whole-Body Cryostimulation Procedure versus Single Dry Sauna Bath: Comparison of Oxidative Impact on Healthy Male Volunteers

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    Paweł Sutkowy

    2015-01-01

    Full Text Available Exposure to extreme heat and cold is one of the environmental factors whose action is precisely based on the mechanisms involving free radicals. Fluctuations in ambient temperature are among the agents that toughen the human organism. The goal of the study was to evaluate the impact of extremely high (dry sauna, DS and low (whole-body cryostimulation, WBC environmental temperatures on the oxidant-antioxidant equilibrium in the blood of healthy male subjects. The subjects performed a single DS bath (n=10; 26.2 ± 4.6 years and a single WBC procedure (n=15; 27.5 ± 3.1 years. In the subjects’ blood taken immediately before and 20 min after the interventions, the activity of superoxide dismutase (SOD, catalase (CAT, and glutathione peroxidase (GPx and the concentration of thiobarbituric acid reactive substances in erythrocytes (TBARSer and blood plasma (TBARSpl were determined. Single WBC and DS procedures induced an increase in the activity of SOD and GPx, as well as SOD and CAT, respectively. The SOD activity was higher after WBC than after DS. Extremely high and low temperatures probably induce the formation of reactive oxygen species in the organisms of healthy men and, therefore, disturb the oxidant-antioxidant balance.

  10. Genetic variants in TP53 and MDM2 associated with male infertility in Chinese population

    Institute of Scientific and Technical Information of China (English)

    Cong Huang; Wei Liu; Gui-Xiang Ji; Ai-Hua Gu; Jian-Hua Qu; Ling Song; Xin-Ru Wang

    2012-01-01

    The TP53,a transcriptional regulator and tumor suppressor,is functionally important in spermatogenesis.MDM2 is a key regulator of the p53 pathway and modulates p53 activity.Both proteins have been functionally linked to germ cell apoptosis,which may affect human infertility,but very little is known on how common polymorphisms in these genes may influence germ cell apoptosis and the risk of male infertility.Thus,this study was designed to test whether three previously described polymorphisms 72Arg>Pro (rs1042522) and the Ex2+ 19C>T (rs2287498) in TP53,and the 5' untranslated region (5' UTR) 309T>G (rs937283) in MDM2,are associated with idiopathic male infertility in a Chinese population.The three polymorphisms were genotyped using OpenArray assay in a hospital-based case-control study,including 580 infertile patients and 580 fertile controls.Our analyses revealed that TP53 Ex2+ 19C>T and MDM2309T>G polymorphisms are associated with mate infertility.Furthermore,we detected a nearly statistically significant additive interaction between TP53 rs2287498 and MDM2 rs937283 for the development of male.infertility (Pinteraction=0.055).In summary,this study found preliminary evidence,demonstrating that genetic variants in genes of the TP53 pathway are risk factors for male infertility.

  11. Possible association between serotonin transporter promoter region polymorphism and extremely violent crime in Chinese males.

    Science.gov (United States)

    Liao, Ding-Lieh; Hong, Chen-Jee; Shih, Hao-Ling; Tsai, Shih-Jen

    2004-01-01

    The neurotransmitter, serotonin, has been implicated in aggressive behavior. The serotonin transporter (5-HTT), which reuptakes serotonin into the nerve terminal, plays a critical role in the regulation of serotonergic function. Previous western reports have demonstrated that the low-activity short (S) allele of the 5-HTT gene-linked polymorphic-region (5-HTTLPR) polymorphism is associated with aggressive behavior and associated personality traits. In the present study, we investigated this 5-HTTLPR genetic polymorphism in a group of Chinese males who had been convicted for extremely violent crime (n = 135) and a normal control group (n = 111). The proportion of S-allele carriers was significantly higher in the criminal group than in the controls (p = 0.006). A significant association was not demonstrated for the relationship between the 5-HTTLPR polymorphism and antisocial personality disorder, substance abuse or alcohol abuse in the criminal group. Our findings demonstrate that carriage of the low-activity S allele is associated with extremely violent criminal behavior in Chinese males, and suggests that the 5-HTT may be implicated in the mechanisms underlying violent behaviors.

  12. Genetic Analysis of IL-17 Gene Polymorphisms in Gout in a Male Chinese Han Population.

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    Zheng Zhou

    Full Text Available Interleukin (IL-17 is a proinflammatory cytokine mainly secreted by activated T helper 17 cells and involved in inflammatory immune responses. This study aimed to investigate the association between IL-17 variants as well as serum IL-17 levels with gout in male Chinese Han individuals. A total of 1,101 male gout patients and 1,239 ethic-matched controls were enrolled. Genetic distributions of three variants (rs2275913 in IL-17A, rs763780 in IL-17F, and rs4819554 in IL-17RA were detected by real-time polymerase chain reaction using the Taqman probe method. The plasma concentrations of IL-17A and IL-17F were measured in 228 gout patients and 198 controls that came from above samples by an enzyme-linked immunosorbent assay. No significant differences were observed in the genetic distribution of these polymorphisms between cases and controls (rs2275913: χ2 = 0.15, p = 0.928 by genotype, χ2 = 0.14, p = 0.711 by allele; rs763780: χ2 = 2.24, p = 0.326 by genotype, χ2 = 0.26, p = 0.609 by allele; rs4819554: χ2 = 1.79, p = 0.409 by genotype, χ2 = 1.46, p = 0.227 by allele. Levels of serum IL-17A and IL-17F were significantly decreased in gout patients (both p0.05. Although the genetic variants in IL-17 we studied in this research do not appear to be involved in the development of gout in male Chinese Han individuals, the IL-17 cytokine family may participate in gouty inflammation in an undefined way, which requires further validation.

  13. Effect of cigarette smoking on clinical outcomes of hospitalized Chinese male smokers with acute myocardial infarction

    Institute of Scientific and Technical Information of China (English)

    ZHANG Hong; SUN Shuai; TONG Lin; LI Rui; CAO Xiang-hong; ZHANG Bian-hua; ZHANG Lin-hu; HUANG Jin-xi; MA Chang-sheng

    2010-01-01

    Background Smoking is known to be a strong risk factor for premature atherosclerosis, acute myocardial infarction (AMI) and sudden cardiac death. According to a cross-sectional survey conducted in 2000-2001 in China, the prevalence of smoking among the Chinese men was 60.2%, the highest prevalence in the world. Up to date, the relationship between smoking and AMI in Chinese male smokers is still unclear. This study analyzed the baseline characteristics for male smokers hospitalized with AMI and investigated the effect of cigarette smoking on their clinical outcomes.Methods A total of 890 men aged 18 years or over with AMI were prospectively recruited from 1 January 2007 to 31 December 2009 from Shanxi Provincial People's Hospital. Patients were grouped into smokers and nonsmokers. The relationships between baseline characteristics and clinical outcomes were tested using either the chi-square test for trend for discrete variables or analysis of variance for continuous variables.Results Smokers accounted for 66.7% (594), more than twice of nonsmokers (296 (33.3%)), and were averaged 7 years younger ((56.61±11.44) vs. (63.61±11.62) years, P <0.001). Smokers had the higher rate of TIMI flow grade 2 or 3 after thrombolytic therapy (42.4 % vs. 24.5%, P=0.002), 1 vessel disease (25.5% vs. 14.5%, P=0.003) than nonsmokers.Smokers had better in-hospital outcome with lower in-hospital mortality rate than nonsmokers (6.2% vs. 10.8%,P=0.023).Conclusions Male smokers suffered from AMI in this study presented an average of 7 years earlier than nonsmokers and were more than twice as likely to have AMI as nonsmokers in China. Smoking appeared to result in earlier infarction,especially ST elevated myocardial infarction in otherwise healthier patients who are likely to survive.

  14. Association of single nucleotide polymorphism Rs2236518 in PRDM16 gene with BMI in Chinese males

    Institute of Scientific and Technical Information of China (English)

    Hua YUE; Jin-wei HE; Yao-hua KE; Hao ZHANG; Chun WANG; Wei-wei HU; Jie-mei GU

    2013-01-01

    PRD1-BF-1-RIZ1 homologous domain containing protein-16 (PRDM16) is a cell-autonomous transcriptional component that stimulates the development of brown fat cells.The aim of this study was to investigate the contribution of genetic variants of PRDM16 to obesity-related phenotype variations in Chinese.Methods:A total of 3204 subjects (consisting of 400 male-offspring nuclear families,401 female-offspring nuclear families,and 729 unrelated older males) were recruited.Ten tag single nucleotide polymorphisms (SNPs) within the PRDM16 gene were genotyped using multiplex quantitative real-time PCR by Taqman assay.Body compositions were measured by dual-energy X-ray absorptiometry (DXA).The associations of the SNPs with the obesity-related phenotypes were analyzed using the quantitative transmission disequilibrium test (QTDT),GLM-ANOVA and PLINK statistical methods.Results:Rs2236518 was the only SNP that was associated with BMI in young (aged 20-40 years) males (P=0.011) using QTDT,and in the older men (aged 50-80 years) (P=0.03) using GLM-ANOVA.No significant associations were detected in the females.Nor was a relationship found between any haplotype and obesity-related phenotypes.When PLINK was used,no significant relationship was detected between 10 SNPs and obesity-related phenotypes in any of the studied cohorts.Conclusion:Rs2236518 is associated with BMI in the young males (using QTDT),and the older males (using GLM-ANOVA).However,the result is not confirmed using PLINK.The discrepancy needs to be further addressed.

  15. Mental health status and related characteristics of Chinese male rural-urban migrant workers.

    Science.gov (United States)

    Yang, Tingzhong; Xu, Xiaochao; Li, Mu; Rockett, Ian R H; Zhu, Waner; Ellison-Barnes, Alejandra

    2012-06-01

    To explore mental health status and related characteristics in a sample of Chinese male rural-urban migrants. Subjects were 1,595 male rural-urban migrant workers selected though a multi-stage sample survey conducted in two cities (Hangzhou and Guangzhou). Data were collected by means of a self-administered questionnaire. Both life and work stressors were examined. Stress and mental health status were measured by the Chinese Perceived Stress Scale (CPSS) and the Chinese Health Questionnaire (CHQ), respectively. Unconditional logistic regression analysis was performed to identify factors associated with probable mental disorders. There are approximately 120 million rural-urban migrants in China. The prevalence of probable mental disorders in the sample population was 24.4% (95% CI: 23.3-25.5%), which was higher than among urban residents (20.2%, 95% CI: 18.8-21.7%). Logistic regression analysis revealed that five characteristics were positively associated with risk for probable mental disorders: originating in the South (OR = 2.00; 95% CI = 1.02, 4.00), higher life stress (OR = 7.63; 95% CI = 5.88, 10.00), staying in the city for 5-9 months each year (OR = 2.56; 95% CI = 1.67, 3.85), higher work stress (OR = 2.56; 95% CI = 1.96, 3.33), and separation from wife (OR = 2.43; 95% CI = 1.61, 3.57). Employment in machinery and transportation (OR = 0.54; 95% CI = 0.36, 0.81) and higher self-worth (OR = 0.42; 95% CI = 0.28, 0.62) were negatively associated. Findings support an urgent need to develop specific policies and programs to address mental health problems among Chinese rural-urban migrants.

  16. Pharmacokinetics and bioavailability study of two ondansetron oral soluble film formulations in fasting healthy male Chinese volunteers

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    Zhu YB

    2015-08-01

    Full Text Available Yubing Zhu,1 Qian Zhang,1 Jianjun Zou,2 Meng Wan,1 Zheng Zhao,1 Junrong Zhu1 1Department of Pharmacy, 2Laboratory of Clinical Pharmacology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China Background: Ondansetron oral soluble film is designed to be applied on top of the tongue without requiring water to aid dissolution or swallowing, which is especially fitting for nausea and vomiting patients.Purpose: This study was conducted to compare the bioavailability of two 8 mg ondansetron oral soluble film formulations.Patients and methods: This randomized, open-label, two-period crossover study was performed under fasting conditions. A total of ten eligible subjects were randomly assigned at a 1:1 ratio to receive a single 8 mg dose of the test and reference ondansetron oral soluble film formulations, followed by a 1-week washout period and administration of the alternate formulation. The concentrations of ondansetron were assayed using an liquid chromatograph-mass spectrometer/mass spectrometer (LC-MS/MS method. For analysis of pharmacokinetic properties, including the peak concentration of Tmax (Cmax, AUC from time 0 (baseline to t hours (AUC0–t, and AUC from baseline to infinity (AUC0–∞, blood samples were obtained at intervals over the 24-hour period after studying drug administration. Tolerability was assessed by monitoring vital signs and laboratory tests (hematology, blood biochemistry, hepatic function, and urinalysis and by questioning subjects about adverse events.Results: The mean (standard derivation [SD] relative bioavailability was 96.5 (23.7%. The 90% confidence intervals (CIs for the log-transformed ratios of Cmax and AUC0–t were 84.71%–103.28% and 91.38%–108.60%, respectively (P>0.05. Similar results were found for the data without log-transformation. No statistically significant differences were found based on analysis of variance. No significant adverse events occurred or were reported during the study.Conclusion: As the 90% CIs based on the differences between the test and reference formulation were within the 80%–125% range for both the Cmax and AUC0–t, we concluded that the two formulations were bioequivalent with respect to the rate or the extent of absorption. Both formulations are well tolerated. Keywords: ondansetron, oral soluble film, LC-MS/MS, bioequivalence  

  17. Factors influencing Chinese male's willingness to undergo circumcision: a cross-sectional study in western China.

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    Xiaobo Yang

    Full Text Available BACKGROUND: Male circumcision (MC has been shown to reduce the risk of female to male transmission of HIV. The goal of this survey was to explore the acceptability of MC among the Chinese and to identify factors associated with circumcision preference. METHODS: A cross-sectional survey was conducted between September 2009 and December 2010. We interviewed 2,219 male community participants, from three high HIV prevalence provinces in western China. A structured questionnaire was used to collect data on MC knowledge, willingness to accept MC, reasons to accept or refuse MC, and sexual behaviors and health. For those who refused MC, a health education intervention providing information on the benefits of circumcision was conducted. We used multiple logistic regression models to identify factors associated with the acceptability of MC. RESULTS: Of the respondents (n = 2,219, 44.6% (989/2,219 reported they would accept MC for the following reasons: promotion of female partners' hygiene (60.3%, redundant foreskin (59.4%, prevention of penile cancer (50.2%, enhanced sexual pleasure (41.4%, and protection against HIV and STDs (34.2%. The multivariable logistic regression showed that five factors were associated with MC willingness: long foreskin (OR = 15.98, residing in Xinjiang province (OR = 3.69, being younger than 25 (OR = 1.60, knowing hazards of redundant foreskin (OR = 1.78, and having a friend who underwent circumcision (OR = 1.36. CONCLUSION: The acceptability of male circumcision was high among the general population in China. Our study elucidates the factors associated with circumcision preference and suggests that more health education campaigns about positive health effects are necessary to increase the MC rate in China.

  18. A Qualitative Study on Chinese Canadian Male Immigrants' Perspectives on Stopping Smoking: Implications for Tobacco Control in China.

    Science.gov (United States)

    Mao, Aimei; Bottorff, Joan L; Oliffe, John L; Sarbit, Gayl; Kelly, Mary T

    2016-04-19

    China has the largest number of smokers in the world; more than half of adult men smoke. Chinese immigrants smoke at lower rates than the mainstream population and other immigrant groups do. This qualitative study was to explore the influence of denormalization in Canada on male Chinese immigrant smoking after migration. Semistructured interviews were conducted with 22 male Chinese Canadian immigrants who were currently smoking or had quit smoking in the past 5 years. The study identified that, while becoming a prospective/father prompted the Chinese smokers to quit or reduce their smoking due to concern of the impacts of their smoking on the health of their young children, changes in smoking were also associated with the smoking environment. Four facilitators were identified which were related to the denomormalized smoking environment in Canada: (a) the stigma related to being a smoker in Canada, (b) conformity with Canadian smoking bans in public places, (c) the reduced social function of smoking in Canadian culture, and (d) the impact of graphic health messages on cigarette packs. Denormalization of tobacco in Canada in combination with collectivist values among Chinese smokers appeared to contribute to participants' reducing and quitting smoking. Although findings of the study cannot be claimed as generalizable to the wider population of Chinese Canadian immigrants due to the small number of the participants, this study provides lessons for the development of tobacco control measures in China to reverse the current prosmoking social environment.

  19. Improved sexual behavior in male rats treated with a Chinese herbal extract: hormonal and neuronal implications

    Institute of Scientific and Technical Information of China (English)

    Paola Zanoli; Augusta Benelli; Manuela Zavatti; Marianna Rivasi; Claudia Baraldi; Mario Baraldi

    2008-01-01

    Aim: To investigate the influence of an extract obtained from five Chinese medicinal plants on sexual behavior of adult male rats. Methods: The extract was administered at doses of 30, 60 and 120 mg/kg by oral gavage, acutely (one time, 45 rain before mating test) or subchronically (daily for 10 days) in sexually potent and sexually sluggish/impo-tent rats. Sexual behavior, serum levels of luteinizing hormone (LH) and testosterone (T) were evaluated in treated rats and compared with controls receiving vehicle. The effect of the extract on central dopaminergic neurotransmis-sion was assessed in the nucleus accumbens using a microdialysis technique. Results: In sexually potent rats, both acute and subchronic treatment with the extract dosed at 30 and 60 mg/kg reduced mount latency and intromission latency. In sluggish/impotent rats, the acutely administered extract at the dose of 60 mg/kg shortened ejaculation latency, whereas subchronically administered at the doses of 30 and 60 mg/kg, reduced mount, intromission and ejaculation latencies, increasing also the percentage of mounting and ejaculating rats. The extract dosed at 60 mg/kg significantly increased LH and T following acute and subchronic administration and increased 3,4-dihydroxyphenylacetic acid levels in the nucleus accumbens, 30 rain after the acute administration. Conclusion: The improvement in both appetitive and consummatory components of sexual behavior observed in male rats treated with the extract could be scribed to increased serum T level in parallel with the activation of the central dopaminergic system.

  20. Pharmacokinetics, safety and tolerability of L-3-n-butylphthalide tablet after single and multiple oral administrations in healthy Chinese volunteers

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    Meng Wang

    2015-09-01

    Full Text Available L-3-n-butylphthalide (L-NBP is a naturally occurring antioxidant, which can be used for the treatment of acute ischemic stroke and vascular dementia. This study evaluated the safety, tolerability and pharmacokinetics of L-NBP tablets in healthy Chinese volunteers. This was a single-center, randomized, double-blind, placebo-controlled, single- and multiple-dose study. Subjects were assigned to receive a single dose of L-NBP tablet at either 80, 160, 320, or 480 mg (n=40, or multiple doses of 160 mg twice daily for 7 days (n=12. Plasma samples were analyzed with LC-MS/MS. Pharmacokinetic parameters of L-NBP were calculated using non-compartmental analysis with WinNonlin software. Statistical analysis was performed using SPSS software. All adverse events (AEs were mild and of limited duration; AEs in this study occurred less frequently and more mildly than AEs listed for the DL-NBP soft capsule. No serious adverse event (SAE, death or withdrawal from the study was observed. In the single-dose study, Cmax was reached at about 1 h, and the mean t1/2 was approximately 13.76 h. Area under curve (AUC and Cmax increased with dose escalation, but dose proportionality was not observed over the range of 160 to 480 mg. In the multiple-dose study, the steady-state was reached within 3 days with slight accumulation. In summary, the L-NBP tablet was well tolerated in healthy Chinese subjects. Slight accumulation appeared after repeated doses.

  1. The Effect of Yokukansan, a Traditional Herbal Preparation Used for the Behavioral and Psychological Symptoms of Dementia, on the Drug-Metabolizing Enzyme Activities in Healthy Male Volunteers.

    Science.gov (United States)

    Soraoka, Hiromi; Oniki, Kentaro; Matsuda, Kazuki; Ono, Tatsumasa; Taharazako, Kosuke; Uchiyashiki, Yoshihiro; Kamihashi, Ryoko; Kita, Ayana; Takashima, Ayaka; Nakagawa, Kazuko; Yasui-Furukori, Norio; Kadowaki, Daisuke; Miyata, Keishi; Saruwatari, Junji

    2016-01-01

    The concomitant use of herb and prescription medications is increasing globally. Herb-drug interactions are therefore a clinically important problem. Yokukansan (YKS), a Japanese traditional herbal medicine, is one of the most frequently used herbal medicines. It is effective for treating the behavioral and psychological symptoms of dementia. We investigated the potential effects of YKS on drug-metabolizing enzyme activities in humans. An open-label repeat-dose study was conducted in 26 healthy Japanese male volunteers (age: 22.7±2.3 years) with no history of smoking. An 8-h urine sample was collected after a 150-mg dose of caffeine and a 30-mg dose of dextromethorphan before and after the administration of YKS (2.5 g, twice a day for 1 week). The activities of cytochrome P450 (CYP) 1A2, CYP2D6, CYP3A, xanthine oxidase (XO) and N-acetyltransferase 2 (NAT2) were assessed based on the urinary metabolic indices of caffeine and dextromethorphan, and the urinary excretion ratio of 6β-hydroxycortisol to cortisol. There were no statistically significant differences in the activities of the examined enzymes before or after the 7-d administration of YKS. Although further studies assessing the influence of YKS on the pharmacokinetics and pharmacodynamics of the substrates of the drug-metabolizing enzymes are needed to verify the present results, YKS is unlikely that a pharmacokinetic interaction will occur with concomitantly administered medications that are predominantly metabolized by the CYP1A2, CYP2D6, CYP3A, XO and NAT2.

  2. Whole body sodium MRI at 3T using an asymmetric birdcage resonator and short echo time sequence: first images of a male volunteer

    Science.gov (United States)

    Wetterling, Friedrich; Corteville, Dominique M.; Kalayciyan, Raffi; Rennings, Andreas; Konstandin, Simon; Nagel, Armin M.; Stark, Helmut; Schad, Lothar R.

    2012-07-01

    Sodium magnetic resonance imaging (23Na MRI) is a non-invasive technique which allows spatial resolution of the tissue sodium concentration (TSC) in the human body. TSC measurements could potentially serve to monitor early treatment success of chemotherapy on patients who suffer from whole body metastases. Yet, the acquisition of whole body sodium (23Na) images has been hampered so far by the lack of large resonators and the extremely low signal-to-noise ratio (SNR) achieved with existing resonator systems. In this study, a 23Na resonator was constructed for whole body 23Na MRI at 3T comprising of a 16-leg, asymmetrical birdcage structure with 34 cm height, 47.5 cm width and 50 cm length. The resonator was driven in quadrature mode and could be used either as a transceiver resonator or, since active decoupling was included, as a transmit-only resonator in conjunction with a receive-only (RO) surface resonator. The relative B1-field profile was simulated and measured on phantoms, and 3D whole body 23Na MRI data of a healthy male volunteer were acquired in five segments with a nominal isotropic resolution of (6 × 6 × 6) mm3 and a 10 min acquisition time per scan. The measured SNR values in the 23Na-MR images varied from 9 ± 2 in calf muscle, 15 ± 2 in brain tissue, 23 ± 2 in the prostate and up to 42 ± 5 in the vertebral discs. Arms, legs, knees and hands could also be resolved with applied resonator and short time-to-echo (TE) (0.5 ms) radial sequence. Up to fivefold SNR improvement was achieved through combining the birdcage with local RO surface coil. In conclusion, 23Na MRI of the entire human body provides sub-cm spatial resolution, which allows resolution of all major human body parts with a scan time of less than 60 min.

  3. LC-MS/MS determination and urinary excretion study of seven alkaloids in healthy Chinese volunteers after oral administration of Shuanghua Baihe tablets.

    Science.gov (United States)

    Cheng, Minlu; Liu, Ruijuan; Wu, Yao; Gu, Pan; Zheng, Lu; Liu, Yujie; Ma, Pengcheng; Ding, Li

    2016-01-25

    An LC-MS/MS method was developed and validated for the simultaneous determination of magnoflorine, berberrubine, jatrorrhizine, coptisine, epiberberine, palmatine and berberine in human urine. The sample preparation procedure involved the four-fold dilution of the urine samples with acetonitrile/water (1:3, v/v). The chromatographic separation was achieved on a Hedera ODS-2 column under gradient elution at a flow rate of 0.4 mL/min with acetonitrile and water containing 0.5% formic acid as the mobile phase. The mass detection was performed in the positive mode. Calibration curves of the seven alkaloids showed good linearity (correlation coefficients>0.9973) over their concentration ranges. To meet the requirements of urinary excretion study for each alkaloid in human, the lower limit of quantification was set at different values from 0.05063 ng/mL to 2.034 ng/mL for the seven alkaloids, respectively. The intra- and inter-batch precision and accuracy were all within ± 15%. No matrix effect was observed for the analytes. The validated method was applied to the excretion study for the seven alkaloids in healthy Chinese volunteers after oral administration of Shuanghua Baihe tablets. The average 72 h cumulative urinary excretion of magnoflorine, berberrubine, jatrorrhizine, coptisine, epiberberine, palmatine and berberine accounted for 1.81%, 0.27%, 0.29%, 0.046%, 0.027%, 0.010% and 0.021% of the respective administered dose.

  4. 中美大学生志愿服务激励机制的比较研究%A Comparative Study of the Inspirational Mechanism of Volunteer Services Between Chinese and American College Students

    Institute of Scientific and Technical Information of China (English)

    龙永红

    2011-01-01

    从来源上看,国家的合法性认同、高校的创新管理、志愿组织与志愿者之间的关系是大学生志愿服务激励机制的重要方面。中美大学生志愿服务激励机制的比较结果表明:志愿服务是一种“有限自愿”行为,需要强化国家在法律规章合法性建构方面的主导性,提升大学生志愿服务在国家社会生活中的显著度;大学生志愿服务行动呈“弥散分布结构”,需要高校建立统一认证考评体系,并将其纳入课程学分、就业指标与素质教育的框架;志愿组织培育好与志愿者的关系,以平等沟通与深度参与方式开发志愿服务的多元活动网络,有助于从内在的满足感与成就感方面激发大学生的志愿热情。%The inspirational mechanism of volunteer services among college students originates from the recognition of the legitimacy from state, the creative management in higher educational institutions and the relationship between the volunteer organizations and volunteers. The comparison of the inspirational mechanism of volunteer services between Chinese and American college students shows that volunteer services is a kind of limited voluntary behaviors, which means that state power should take the leadership in the construction of a legalized framework of laws and regulations so as to highlight the importance of volunteer services of college students in the social life of the whole country. The scattered structure of volunteer service of college students determines that higher educational institutions should establish a unified evaluation and testing system to include it in the framework of course credits, employment target and quality education. The volunteer organizations are supposed to cultivate its relationship with volunteers to expand the diversification of volunteer activities by equal communication and deep involvement, which stimulates the passion of volunteers by meeting their internal

  5. Relationship of carotid intima-media thickness and duration of vegetarian diet in Chinese male vegetarians

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    Liu Chang-Qin

    2011-09-01

    Full Text Available Abstract Objective Many studies have shown that vegetarian diet has beneficial effects on the prevention of cardiovascular diseases. However, the effect of vegetarian diet on carotid intima-media thickness (IMT, as well as the association between IMT and duration of vegetarian diet, are still unclear. The present study aims to investigate the influence of duration of vegetarian diet on cardiovascular risk factors, and more importantly on IMT among Chinese vegetarians. Methods One hundred and seventy-one Chinese male vegetarians were screened for metabolic profile, cardiovascular risk and carotid IMT. They were compared with 129 age-matched omnivores recruited from a community-based health project. The effects of confounding factors were adjusted by stepwise logistic regression analysis. Results Compared to the omnivores, the vegetarians had lower BMI, weight, systolic blood pressure and diastolic blood pressure. Also, the levels of triglyceride, total cholesterol, HDL-Cholesterol, LDL-Cholesterol, ApoA1, ApoB, uric acid, albumin and γ-glutamyltransferase were significantly reduced in vegetarians. Omnivores had significantly higher fasting blood glucose than that of vegetarians. However, there were no differences in fasting insulin, C-reactive protein and HOMA-IR between the two groups. IMT was thinner in the vegetarian group than in the omnivore group (0.59 ± 0.16 vs. 0.63 ± 0.10 cm, P 11 years, those in tertile 1 ( Conclusion A decrease in multiple cardiovascular risk factors such as BMI, blood pressure and lipid profile was associated with vegetarian diet. Moreover, taking a low-calorie, low-protein, or vegetarian diet might have great beneficial effects on IMT through improved lipid profile, and the beneficial effects appeared to be correlated with the duration of vegetarian diet.

  6. Chinese female breast cancer patients show a better overall survival than their male counterparts

    Institute of Scientific and Technical Information of China (English)

    XIA Liang-ping; ZHOU Fei-fei; GUO Gui-fang; WANG Fang; WANG Xi; YUAN Zhong-yu; ZHANG Bei

    2010-01-01

    Backgroud It is not clear if there is a difference in prognosis between male breast cancer (MBC) and female breast cancer (FBC) patients. The aim of this study was to compare the prognosis of MBC and FBC patients in China and the prognosis of MBC and their corresponding postmenopausal FBC patients.Methods Thirty-five MBC patients who were treated at the Sun Yat-sen University Cancer Center between 1969 and 2004 were enrolled in the study. Seventy FBC patients who were matched with the MBC patients for TNM stage, year of diagnosis, and age at diagnosis were simultaneously enrolled in the study. A second group comprising 18 MBC patients and their corresponding 36 matched postmenopausal FBC patients were also enrolled. The whole group and the postmenopausal groups were compared for five- and ten-year survivals. Results All the factors that could potentially affect prognosis were comparable among the groups except more FBC than MBC patients underwent endocrine therapy and a modified radical mastectomy. The 5- and 10-year survivals in the whole group were 81.6% and 60.3% for men and 90.7% and 73.5% for women (P=0.02). The 5- and 10-year survival in the postmenopausal group was 82.5% and 100% for men and 66.0% and 85.9% for women (P=0.159).Conclusions Chinese FBC patients had a better prognosis than Chinese MBC patients. However, MBC patients and their corresponding postmenopausal FBC patients had a similar prognosis.

  7. Polymorphisms of alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 and colorectal cancer risk in Chinese males

    Institute of Scientific and Technical Information of China (English)

    Chang-Ming Gao; Keitaro Matsuo; Nobuyuki Hamajima; Kazuo Tajima; Toshiro Takezaki; Jian-Zhong Wu; Xiao-Mei Zhang; Hai-Xia Cao; Jian-Hua Ding; Yan-Ting Liu; Su-Ping Li; Jia Cao

    2008-01-01

    AIM: To evaluate the relationship between drinking and polymorphisms of alcohol dehydrogenase 2 (ADH2) and/or aldehyde dehydrogenase 2 (ALDH2) for risk of colorectal cancer (CRC) in Chinese males.METHODS: A case-control study was conducted in 190 cases and 223 population-based controls.ADH2 Arg47His (G-A) and ALDH2 Glu487Lys (G-A) genotypes were identified by PCR and denaturing high-performance liquid chromatography (DHPLC).Information on smoking and drinking was collected and odds ratio (OR) was estimated.RESULTS: The ADH2 A/A and ALDH2 G/G genotypes showed moderately increased CRC risk. The age- and smoking-adjusted OR for ADH2 A/A relative to G/A and G/G was 1.60 (95% CI=1.08-2.36), and the adjusted OR for ALDH2 G/G relative to G/A and A/A was 1.79 (95% CI=1.19-2.69). Significant interactions between ADH2,ALDH2 and drinking were observed. As compared to the subjects with ADH2 G and ALDH2 A alleles, those with ADH2 A/A and ALDH2 G/G genotypes had a significantly increased OR (3.05, 95% CI= 1.67-5.57). The OR for CRC among drinkers with the ,4DH2 A/A genotype was increased to 3.44 (95% CI= 1.84-6.42) compared with non-drinkers with the ADH2 G allele. The OR for CRC among drinkers with theALDH2 G/G genotype was also increased to 2.70 (95% CI= 1.57-4.66) compared with non-drinkers with the ALDH2 A allele.CONCLUSION: Polymorphisms of the ADH2 and ALDH2 genes are significantly associated with CRC risk. There are also significant gene-gene and geneenvironment interactions between drinking and ADH2 and ALDH2 polymorphisms regarding CRC risk in Chinese males.

  8. Pharmacokinetic comparison of sustained- and immediate-release formulations of cilostazol after multiple oral doses in fed healthy male Korean volunteers

    Directory of Open Access Journals (Sweden)

    Kim YH

    2015-07-01

    Full Text Available Yo Han Kim,1 Jong-Lyul Ghim,2 Jin Ah Jung,2 Sang-Heon Cho,3 Sangmin Choe,4 Hee Youn Choi,1 Kyun-Seop Bae,1 Hyeong-Seok Lim1 1Department of Clinical Pharmacology and Therapeutics, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, 2Department of Clinical Pharmacology, Inje University, Busan Paik Hospital, Busan, 3Department of Clinical Pharmacology, Inha University Hospital, Inha University School of Medicine, Incheon, 4Clinical Trials Center, Pusan National University Hospital, Busan, Republic of Korea Background: A new extended-release form of cilostazol has recently been developed. This study was conducted to compare the pharmacokinetic characteristics of sustained-release (SR and immediate-release (IR formulations of cilostazol after multiple oral doses in healthy male Korean volunteers.Methods: This was an open-label, randomized, multiple-dose, crossover study conducted in 30 healthy Korean subjects. In each treatment period, subjects received oral doses of 200 mg SR formulation every 24 hours or 100 mg IR formulation every 12 hours for 5 consecutive days in a fed state, with a washout period of 9 days. The plasma concentrations of cilostazol and its metabolites were determined using a validated liquid chromatography-tandem mass spectrometry method. The area under the plasma concentration–time curve within a dosing interval (AUCT, the measured peak plasma concentration at steady state (Cmax,ss, and the time to reach Cmax,ss (tmax,ss were analyzed using a noncompartmental method. Results: A total of 24 healthy male subjects completed the study. The mean (standard deviation [SD] AUCT (96–120 hours values for SR and IR were 27,378.0 (10,301.6 ng·h/mL and 27,860.3 (7,152.3 ng·h/mL, respectively. The mean (SD Cmax,ss values were 2,741.4 (836.0 ng/mL and 2,051.0 (433.2 ng/mL, respectively. The median tmax,ss values were 8.0 hours and 4.0 hours, respectively. The geometric mean ratios (90% confidence intervals of

  9. A sensitive LC-MS/MS method for analysis of pericyazine in presence of 7-hydroxypericyazine and pericyazine sulphoxide in human plasma and its application to a comparative bioequivalence study in Chinese healthy volunteers.

    Science.gov (United States)

    Cai, Hua Lin; Deng, Yang; Fang, Ping Fei; Cao, SiSi; Hou, Zhen Yan; Wu, Yan Qin; Chen, Xue Jiao; Yan, Miao; Zhang, BiKui

    2017-02-20

    A robust and highly sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the determination of pericyazine in human plasma. The plasma sample was alkalized with sodium hydroxide solution and handled by liquid-liquid extraction with ethyl acetate after adding perphenazine as an internal standard (IS). The analytes were separated on an Ultimate™ AQ-C18 analytical column at 40°C, with a gradient elution consisting of A (aqueous phase: 5mM ammonium acetate buffer solution containing 0.1% formic acid) and B (organic phase: acetonitrile) at a flow rate of 0.350mL/min. The detection was conducted on an API 4000 tandem mass spectrometer coupled with electrospray ionization (ESI) source in positive ion mode. The multiple reaction monitoring (MRM) transitions, m/z 366.5>142.4 for pericyazine, m/z 382.5>142.4 for its 7-hydroxy and sulphoxide metabolites and m/z 404.3>171.3 for IS were chosen to achieve high selectivity in the simultaneous analyses. The method exhibited great improvement in sensitivity (LLOQ of 0.021ng/mL) and good linearity over the concentration range of 0.021-9.90ng/mL. The intra- and inter-day precision, accuracy, and stability results were within the acceptable limits and no matrix effect was observed. This method was successfully applied in a bioequivalence study to evaluate the pharmacokinetics in 20 healthy male Chinese volunteers. Additional exploratory analyses of 7-hydroxy and sulphoxide metabolites of pericyazine in the same samples suggest that the unchanged drug is predominant in the plasma and suitable for the bioequivalence comparison after a single oral administration of 10mg pericyazine.

  10. Cigarette smoking and cognitive function in Chinese male schizophrenia: a case-control study.

    Directory of Open Access Journals (Sweden)

    Xiang Yang Zhang

    Full Text Available Schizophrenic patients have higher smoking rates than the general population. Studies show that smoking may be a form of self-medication in an attempt to alleviate cognitive deficits in schizophrenic patients of European background. This study examined the relationships between smoking and cognitive deficits in Chinese schizophrenic patients, which have previously received little systemic study. We recruited 580 male chronic patients meeting DSM-IV criteria for schizophrenia and 175 male control subjects who were matched on age and education. The subjects completed a detailed cigarette smoking questionnaire, the Fagerstrom Test for Nicotine Dependence (FTND, and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS. Patients also were rated on the Positive and Negative Symptom Scale (PANSS, the Simpson and Angus Extrapyramidal Symptom Rating Scale (SAES, and the Abnormal Involuntary Movement Scale (AIMS. All five RBANS subscales except for the Visuospatial/Constructional index showed significantly lower cognitive performance for schizophrenics than normal controls. The schizophrenic smokers scored lower than the schizophrenic non-smokers on the RBANS total score and the Visuospatial/Constructional and Immediate Memory indices. Similarly, the control smokers scored lower than the control non-smokers on the RBANS total score and the Immediate Memory index . Also, the schizophrenic smokers consistently performed the poorest on the cognitive domains of the RBANS. Among the schizophrenic patients, smokers displayed significantly fewer negative symptoms than non-smokers. Using multivariate regression analysis the following variables were independently associated with the RBANS total score: years of education, PANSS negative symptom score, age at schizophrenia onset, and number of hospitalizations. Our results show that smoking is associated with significant cognitive impairment in both schizophrenic patients and normal controls

  11. Acceptability of early infant male circumcision among chinese parents: strategy implications of HIV prevention for china

    Directory of Open Access Journals (Sweden)

    Pan Lianjun

    2012-09-01

    Full Text Available Abstract Background Recent evidence has confirmed that circumcision can be performed as a preventive strategy for HIV and early infant male circumcision (EIMC is regarded to be safer than circumcision in adulthood; however, limited data are available in the literature about EIMC in China. Therefore, the present study was designed to determine the willingness and attitudes of Chinese parents on newborn male circumcision so as to provide data for exploring the feasibility of implementing EIMC as an HIV prevention strategy in China. Methods Simple random sampling was used to draw participants from parents who had a newborn son delivered at Nanjing Maternity and Child Health Care Hospital, which is affiliated to Nanjing Medical University, between March and December 2010. A questionnaire was used to determine general medical knowledge or information about circumcision, attitudes about EIMC, and level of decision-making on circumcision for the newborn son. Results Data derived from 558 responses were analyzed and the ratio of respondents was 56.3% for fathers and 43.6% for mothers. Of the respondents, 34.4% agreed to circumcise their newborn son, and the level of agreement was 3.25 ± 1.17 (range, 1–5 with “1” being “reluctantly agree” and “5” being “very strongly agree”. The major reason for EIMC was for health (44.8%, followed by doctor’s advice (31.2%. The major reason not to agree to EIMC was concern about pain (50.5%, followed by the risk of the procedure (23.5%. Conclusion The willingness and acceptability of EIMC in China is low and the parents of newborn sons are usually not very affirmative when making a decision on such a procedure, suggesting that significant effort will be needed if EIMC is to be implemented as an HIV prevention strategy for China.

  12. 盐酸特拉唑嗪分散片的人体生物利用度%Bioavailability of terazosin hydrochloride dispersible tablets in Chinese healthy volunteers

    Institute of Scientific and Technical Information of China (English)

    张志涛; 李见春; 蒋志文

    2009-01-01

    OBJECTIVE To study the relative bioequivalence of terazosin HCI dispersible tablets and its domestic convention-al tablets in Chinese healthy volunteers. METHODS A single oral dose of 2 mg terazosin HC1 was randomly given to 20 healthy volunteers in two-way cross-over design. Plasma concentration of terazosin HCI was determined by HPLC-fluoremetry method. Pharmacokinetics parameters were calculated. The bioequivalence of the two preparations was calculated by analysis of variance and two one side t-test. RESULTS After oral administration, the main pharmacokinetics parameters of test and reference CONCLUSION The two preparations were bioequivalent.%目的:研究盐酸特拉唑嗪分散片和国产普通片的人体生物等效性.方法:20名健康男性受试者自身交叉单剂量口服盐酸特拉唑嗪分散片和国产普通片,采用高效液相色谱-荧光法测定血浆药物浓度,计算药动学参数,以方差分析与双向单侧t检验进行统计学分析.结果:盐酸特拉唑嗪分散片和国产普通片的Gmax分别为(29.8±9.3)μg·L-1和(31.0±9.8)μg·L-1,tmax分别为(0.8±0.1)h和(1.5±0.9)h,AUC0→t分别为(325.9±75.5)μg·h·L-1和(362.3±105.6)μg·h·L-1.盐酸特拉唑嗪分散片的相对生物利用度为(91.5±26.6)%.结论:2种制剂具有生物等效性.

  13. Student Volunteering in China and Canada:Comparative Perspectives

    OpenAIRE

    Lesley Hustinx; Cnaan, Ram A; Femida Handy

    2012-01-01

    While many of the theoretical frameworks for volunteering have beendeveloped and empirically tested in the West, our understanding of volunteering in non-Western countries, such as China, is relatively limited. Nevertheless, in recent decades enormous efforts have been made by the Chinese government to encourage and support volunteering among its citizens, especially youth. Chinese youth are volunteering in greater numbers in response to these initiatives. Given the strongly state-led nature ...

  14. Moral Disengagement as Mediator and Moderator of the Relation Between Empathy and Aggression Among Chinese Male Juvenile Delinquents.

    Science.gov (United States)

    Wang, Xingchao; Lei, Li; Yang, Jiping; Gao, Ling; Zhao, Fengqing

    2017-04-01

    The link between empathy and aggression is well documented; yet, studies examining potential mechanisms that explain this association are limited. In the present study, we tested the relation between empathy and aggression and examined both the mediating and moderating effects of moral disengagement on this relation among Chinese male juvenile delinquents. Three hundred and fifty-seven male juvenile delinquents from one Chinese juvenile correctional facility completed the interpersonal reactivity index, the moral disengagement scale and the aggression questionnaire. The results indicated that moral disengagement partially mediated the influence of empathy on aggression. Moreover, moral disengagement moderated the relation between empathy and aggression. Specifically, there was a significant negative relation between empathy and aggression at low levels of moral disengagement. However, at high levels of moral disengagement, the relation between empathy and aggression was non-significant. The significance and limitations of the results are discussed.

  15. 氟氯西林钠胶囊在中国健康人体的药代动力学%Pharmacokinetics of Flucloxacillin Capsules in Chinese Healthy Volunteers

    Institute of Scientific and Technical Information of China (English)

    李忠亮; 王晓波; 袭荣刚; 张治然

    2012-01-01

    Objective To study the pharmacokinetics of a single dose of flucloxacillin capsules in Chinese healthy volunteers. Methods Twenty-four healthy volunteers were divided into three groups by 3 x 3. design. The drug concentration of the plasma sample from the twenty-four volunteers after taking 0. 25,0. 5,1 g flucloxacillin was determined by HPLC. The pharmacokinetic parameters were calculated by DAS software and were statistically analyzed by SPSS software. Results The healthy volunteers were given a single dose of flucloxacillin of 0.25,0. 5,1 g, respectively. The main pharmacokinetic parameters were as follows: C max was (8.29 ±0.51),(15.93 ±4.21), (30.62 ±9.63) μg/ml, tmax was (0.96 ±0.05),(0.93 ±0.07),(1.03 ±0.06) h, t l/2 was (1.24 ±0.06) ,(1.53 ±0.29),(1.55 ±0.28) h, AUC0.l0was (30.52 ±9.17),(60.64 ±13.26),(118.39 ±19.38) μg ·h/ml, CL/F was (9.03 ±0.61) ,(9.61 ±0.84), (9.52 ±0.82)L/h. respectively. The main pharmacokinetic parameters CMAXAUC0-10.AUC0-∞ were in direct proportion to the dose. There was no singnificant difference in Ka, Ke, t max, t1/2 and CL/F between the three groups by analysis of variance. Conclusion The pharmacokinetics of flucloxacillin at different dosage in healthy volunteers conforms to the linear dynamic feature. The plasma concentration-time curve of flucloxacillin is fitted to a two-compartment open model.%目的 研究健康受试者单次口服氟氯西林钠胶囊的药代动力学特征.方法 健康受试者24名,按3×3拉丁方设计,分别单次口服氟氯西林钠胶囊0.25、0.5、1g后,采用HPLC法测定血浆中氟氯西林的浓度.用DAS软件程序进行数据处理,用SPSS软件对不同性别药代动力学参数进行统计分析,求算药代动力学参数.结果 3个不同剂量组氟氯西林的主要药代动力学参数:Cmax分别为(8.29±0.51)、(15.93±4.21)、(30.62±9.63)μg/ml,tmax分别为(0.96±0.05)、(0.93±0.07)、(1.03±0.06)h,t 1/2分别为(1.24±0.06)、(1.53±0.29)、(1.55 ±0

  16. Inter- and Intra-individual Variability in the Pharmacokinetics of Agomelatine Tablets in Chinese Healthy Male Subjects.

    Science.gov (United States)

    Wang, X-l; Du, A-h; Zhang, D; Meng, L-j; Liu, M; Zhang, L-n; Zhao, H-n; Liu, H-c

    2015-10-01

    Agomelatine is an antidepressant with a unique action mechanism differing from conventional antidepressants. The high inter- and intra-individual variability of agomelatine was previously reported, but no exact data values about the inter- and intra-individual variability in AUC and Cmax were mentioned. The current study aimed to determine and evaluate the inter- and intra-individual variability in AUC and Cmax of agomelatine tablets in Chinese healthy male subjects, providing useful information for designing bioequivalence studies of agomelatine. Each of 12 Chinese healthy male subjects received a 25-mg agomelatine tablet on 2 separate periods, and plasma samples were collected up to 24 h after dose and analyzed for agomelatine. Inter- and intra-individual variability in the pharmacokinetic parameters (Cmax, AUC0-t and AUC0-∞) of agomelatine was assessed. High variations in the plasma concentrations of agomelatine could be observed at each sampling time between the different subjects and in one subject on different periods. The inter-individual CVs of Cmax, AUC0-t and AUC0-∞ were 102.20%, 131.74% and 130.59%, respectively. The intra-individual CVs of Cmax, AUC0-t and AUC0-∞ were 84.34%, 49.61% and 50.83%, respectively. The results showed high inter- and intra-individual variability in the pharmacokinetics of agomelatine in Chinese healthy male subjects, and the intra-individual variability at CV>80% should be considered in the design of bioequivalence studies.

  17. Establishment of the population pharmacokinetics model of sibutramine in Chinese healthy volunteers%中国健康人群西布曲明的群体药动学模型的建立

    Institute of Scientific and Technical Information of China (English)

    陈晓晶; 李中东; 丁俊杰; 施孝金; 徐一新

    2012-01-01

    目的 建立中国人群中西布曲明的群体药动学模型.方法 20例男性健康志愿者口服10 mg西布曲明,于服药后0 ~24 h采集13个采样点采血,采用已验证的HPLC法测定血药浓度.采用非线性混合效应模型(NONMEM)进行群体药动学分析,估算药动学参数.以直观预测检验( Visual predictive check,VPC)和正态预测分布误差(Normalized predictive distribution error,NPDE),Bootstrap法进行模型性能评估.结果 以有吸收时滞的一级吸收和消除的二房室模型为西布曲明的基础药动学模型.协变量筛选未见体重、年龄可显著影响模型参数.残差模型选择指数模型.西布曲明群体药动学参数V1,V2,CL,Q,Ka,Tlag的典型值分别为:7.85 L、2.03 L、1.08 L/h、0.289 L/h、1.95/h、0.187 h;个体间变异分别为42.8%、48.2%、38.5%、27.1%、56.8%和17.8%.Bootstrape、拟合优度、VPC和NPDE的评价结果均表明模型稳定,预测结果可靠.结论 用非线性混合效应模型法建立的中国人群中西布曲明的群体药动学模型,结果稳定.%Objective To develop the population pharmacokinetics model of sibutramine ( SIB) in Chinese healthy volunteers. Methods Twenty male healthy volunteers were enrolled into the study. 13 blood sampling were drawn after administration of 10 mg SIB within 24 h. The plasma samples for SIB concentration were analyzed using validated HPLC/MS method. The population pharmacokinetics was characterized by non-linear mixed effects model (NONMEM). Visual predictive check (VPC) and normalized predictive distribution error ( NPDE) were used to evaluate the predictive ability of the model. The reliability and stability of the population pharmacokinetic model developed was further assessed by a nonparametric bootstrap procedure. Results A two-compartment pharma-cokinetic model with first-order absorption and elimination was used to describe the concentration-time data. The weight and age had no significant

  18. Association between 5-hydroxytryptamine transporter gene-linked polymorphic region and smoking behavior in Chinese males

    Institute of Scientific and Technical Information of China (English)

    CHU Shui-lian; XIAO Dan; WANG Chen; JING Hang

    2009-01-01

    Background Tobacco use is the major risk factor for numerous health problems. However, only 5% of smokers can successfully quit without therapy owing to the highly addictive properties of nicotine. The serotoninergic system may be involved in smoking behavior because nicotine increases brain serotonin secretion, nicotine withdrawal decreases serotonin levels, and a selective serotonin reuptake inhibitor antagonizes the response to nicotine withdrawal. Serotonin transporter (5-HTT) is the most important protein, as it adjusts the serotonin concentration in the synaptic cleft. There is a polymorphism in the upstream regulatory region of the 5-HTT gene, named 5-hydroxytryptamine transporter gene-Iinked poyymorphic region (5-HTTLPR). Compared with the L allele, the S allele of the polymorphism is associated with decreased transcription efficiency of the 5-HTT gene. In this study, we investigated the relationship between this gene polymorphism and smoking behavior in Chinese males.Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed to find 5-HTTLPR gene polymorphisms in 144 smokers and 135 age-matched healthy non-smokers. A questionnaire was completed in all recruited subjects.Results The proportion of L/L (15.3% vs 5.2%) and S/L (50.0% vs 33.3%) genotypes was significantly higher in the smokers than that in the non-smokers (χ2=21.9; P <0.01). The odds ratio (OR) adjusted by age, education, effects of family members and friends who smoke, and alcohol intake was 2.9 (95%CI 1.78-4.80). In smokers, the number of cigarettes/day (L/L vs S/L vs S/S: 28+12 vs 20±8 vs 16±6, χ2=18.5, P <0.01), smoking index (L/L vs S/L vs S/S.. 561±446vs 393±341 vs 237+901, χ2=12.5, P <0.01) and score on the Fagerstrom test for nicotine dependence (FTND) (L/L vs S/L vs S/S. 7.8±1.6 vs 6.2±9.5 vs 3.5±9.1, χ2=48.3, P <0.01) were significantly higher in smokers with an L/L or S/L genotype than that in the smokers with the S/S genotype

  19. Contribution of Myostatin gene polymorphisms to normal variation in lean mass, fat mass and peak BMD in Chinese male offspring

    Institute of Scientific and Technical Information of China (English)

    Hua YUE; Miao LI; Yu-juan LIU; Song-hua WU; Zhen-lin ZHANG; Jin-wei HE; Hao ZHANG; Chun WANG; Wei-wei HU; Jie-mei GU; Yao-hua KE; Wen-zhen FU; Yun-qiu HU

    2012-01-01

    Myostatin gene is a member of the transforming growth factor-β (TGF-β) family that negatively regulates skeletal muscle growth.Genetic polymorphisms in Myostatin were found to be associated with the peak bone mineral density (BMD) in Chinese women.The purpose of this study was to investigate whether Myostatin played a role in the normal variation in peak BMD,lean mass (LM),and fat mass (FM) of Chinese men.Methods:Four hundred male-offspring nuclear families of Chinese Han ethnic group were recruited.Anthropometric measurements,includingthe peak BMD,body LM and FM were measured using dual-energy X-ray absorptiometry (DXA).The single nucleotide polymorphisms (SNPs) studied were tag-SNPs selected by sequencing.Both rs2293284 and +2278G>A were genotyped using TaqMan assay,and rs3791783 was genotyped with PCR-restriction fragment length polymorphism (RFLP) analysis.The associations of the SNPs with anthropometfic variations were analyzed using the quantitative transmission disequilibrium test (QTDT).Results:Using QTDT to detect within-family associations,neither single SNP nor haplotype was found to be associated with peak BMD at any bone site.However,rs3791783 was found to be significantly associated with fat mass of the trunk (P<0.001).Moreover,for within-family associations,haplotypes AGG,AAA,and TGG were found to be significantly associated with the trunk fat mass (all P<0.001).Conclusion:Our results suggest that genetic variation within Myostatin may play a role in regulating the variation in fat mass in Chinese males.Additionally,the Myostatin gene may be a candidate that determines body fat mass in Chinese men.

  20. 丙泊酚注射液在中国健康志愿者中的药动/药效学研究%Pharmacokinetics/pharmacodynamics evaluation of two injection formulations of propofol in Chinese healthy volunteers

    Institute of Scientific and Technical Information of China (English)

    陈琳瑶; 周星辰; 郭歆; 苏桃; 程泽能

    2012-01-01

    Propofol is a widely used intravenous anesthetic agent.Few pharmacokinetic (PK) and pharmacodynamic (PD) information of propofol is available in a Chinese population.The aim of the study is to evaluate PK and PD characteristics,assessing the therapeutic equivalence between two injection formulations of propofol in Chinese healthy volunteers.METHODS:Twenty-four healthy male volunteers were enrolled in a randomized,double-blinded,crossover study,receiving a 2 mg/kg bolus injection of test or reference formulation in two study arms.Plasma propofol concentration was determined by a validated HPLC-Flu method.PD parameters,Bispectral Index (BIS) and A-line ARX Index (AAI),were recorded by EEG monitor till 15 min postdose.In addition,times to onset of and emergence from hypnosis were observed.RESULTS:Twenty-three subjects accomplished the trial.The mean values of C tmax,AUC0-t,AUC0-∞ of test and reference formulations were 2.284 and 2.452 mg/L; 4 and 4min; 0.706 and 0.423 mg · h · L-1 ; 0.471 and 0.506 mg · h · L-1,respectively.The mean values of PD parameters of test and reference formulations were as follows:BISmin,51 and 53,respectively; AAImin,18 and 20 ; BISAUC0-15min,373.4 and 342.7; AAIAUC0-15min,892.5 and 850.5.The 90% CIs for the logarithmic transformations of C AUC0-t,AUC0-∞,BISAUC0-15min,BISmin,AAIAUC0-15min,AAImin (0.795-0.999,0.838-0.985,0.861-0.989,1.023-1.151,0.865-1.025,0.999-1.099,0.826-1.008,respectively) were within the bioequivalence acceptance limits.No serious adverse events occurred in the trial.CONCLUSION:Results indicated that no significant difference was found between test and reference formulations of,propofol in the aspects of pharmacokinetic and pharmacodynamic.Both formulations were well tolerated.Therefore,we believe that the two injection formulations of propofol are therapeutic equivalence in Chinese healthy volunteers.%目的:丙泊酚是临床上广泛使用的短效静脉麻醉药,本文通过研究丙泊酚的药动学和

  1. Cigarette smoking in male patients with chronic schizophrenia in a Chinese population: prevalence and relationship to clinical phenotypes.

    Directory of Open Access Journals (Sweden)

    Xiang Yang Zhang

    Full Text Available The high prevalence of smoking in schizophrenia of European background may be related to smoking's reducing clinical symptoms and medication side effects. Because smoking prevalence and its associations with clinical phenotypes are less well characterized in Chinese than European patients with schizophrenia, we assessed these smoking behaviors using clinician-administered questionnaires and the Fagerstrom Test for Nicotine Dependence (FTND in 776 Chinese male schizophrenia and 560 control subjects. Patients also were rated on the Positive and Negative Symptom Scale (PANSS, the Simpson and Angus Extrapyramidal Symptom Rating Scale (SAES, and the Abnormal Involuntary Movement Scale (AIMS. We found that the schizophrenia patients had a higher lifetime incidence of smoking (79% vs 63%, were more likely to be heavy smokers (61% vs 31%, and had lower smoking cessation rates (4% vs 9% (all p0.05 than the non-smoking patients. These results suggest that Chinese males with schizophrenia smoke more frequently than the general population. Further, smokers with schizophrenia may display fewer negative symptoms and possibly less parkinsonism than non-smokers with schizophrenia.

  2. 赴泰汉语教师志愿者心理濡化研究%A Qualitative Study of the Psychological Acculturation of Chinese Volunteer Teachers in Thailand

    Institute of Scientific and Technical Information of China (English)

    安然; 魏先鹏

    2012-01-01

    目前为我国汉语国际推广项目而工作的外派汉语教师志愿者已达万人,但是学界对该群体的关注却很有限。本研究以泰国汉语教师志愿者为研究对象,采用深度访谈的方法,考察赴泰汉语教师志愿者心理濡化过程和结果。发现影响志愿者的心理濡化因素有心理预期、社会支持、人际交流、他人期望等,这些因素交汇于“交流”,在交流基础之上的自我效能感和成就感,则是心理濡化这一结果的初级表现,全球化心态则是高级表现。汉语教师志愿者的心理濡化过程中,体现出集体主义、孝道观念和人际关系和谐理念中国文化价值观。%Through in-depth interviews, this study focuses on Chinese volunteer teachers" psychologi- cal acculturation in terms of its process and results. It has proved that such factors as psychological expectations, social support, interpersonal communication and others" expectation will affect these volunteers' adaptation, which finds full expression in "communication". With is, self efficacy and ful- fillment are the initial expression of such psychological acculturation while the global mindset is its fi- nal expression. Some Chinese cultural values, such as collectivism, filial piety and harmony, are em- bodied in the process of Chinese volunteer teachers" psychological acculturation.

  3. Genetic polymorphism of interleukin-6 influences susceptibility to HBV-related hepatocellular carcinoma in a male Chinese Han population.

    Science.gov (United States)

    Tang, Shengli; Yuan, Yufeng; He, Yueming; Pan, Dingyu; Zhang, Yongxi; Liu, Yuanyuan; Liu, Quanyan; Zhang, Zhonglin; Liu, Zhisu

    2014-04-01

    As a multifunctional cytokine, interleukin-6 (IL-6) plays a key role in chronic inflammation as well as tumor growth and progression of hepatitis B virus (HBV) infection. Recent studies have implicated that single nucleotide polymorphism (SNP) -572C>G (rs1800796) located within the promoter region of IL-6 gene was associated with susceptibility to several diseases. Here, a case-control study was undertaken to investigate the association between this polymorphism and HBV-related hepatocellular carcinoma (HCC) susceptibility in a Chinese Han population. A total of 900 patients with chronic HBV infection, including 505 HBV-related HCC patients and 395 HBV infected patients without HCC were enrolled, and rs1800796 polymorphism was genotyped by the TaqMan method and DNA sequencing technology. The results indicated no significant association between rs1800796 polymorphism and the risk of HBV-related HCC in all subjects; however, a significant difference was identified in male subjects. Under the dominant model, male subjects with the G allele (CG/GG) have higher susceptibility to HBV-related HCC than those with CC genotype after adjusting confounding factors (P=0.012, odds ratio [OR] 1.68, 95% confidence interval [95% CI] 1.15-2.42). Our results suggested that rs1800796 polymorphism of IL-6 gene was associated with susceptibility to HBV-related HCC in a male Chinese Han population.

  4. Association of ALOX15 gene polymorphisms with obesity-related phenotypes in Chinese nuclear families with male offspring

    Institute of Scientific and Technical Information of China (English)

    Yao-hua KE; Chun WANG; Yun-qiu HU; Miao LI; Yu-juan LIU; Wen-zhen FU; Zhen-lin ZHANG; Wen-jin XIAO; Jin-wei HE; Hao ZHANG; Jin-bo YU; Wei-wei HU; Jie-mei GU; Gao GAO; Hua YUE

    2012-01-01

    Aim:Genetic variation in ALOX12,which encoded human 12-lipoxygenase,was found to be associated with fat mass in young Chinese men.The objective of this study was to investigate the relationship between single nucleotide polymorphisms (SNPs) and haplotypes in the ALOX15 gene and obesity-related phenotypes in Chinese nuclear families with male offspring.Methods:We recruited 1,296 subjects from 427 nuclear families with male offspring and genotyped five SNPs (rs9894225,rs748694,rs2619112,rs2619118,and rs916055) in the ALOX15 gene locus.The total fat mass (TFM),trunk fat mass (tFM),leg fat mass (LFM) and arm fat mass (AFM) were measured using dual-energy X-ray absorptiometry (DXA).The percentage of fat mass (PFM) was the ratio of TFM and body weight.The association between SNPs and haplotypes of ALOX15 and obesity-related phenotypic variation was measured using quantitative transmission disequilibrium test (QTDT).Results:Using QTDT to measure family-based genetic association,we found that rs916055 had a statistically significant association with PFM (P=0.038),whereas rs916055 had a marginal but statistically insignificant association with tFM (P=0.093).The multipleparameter 1000 permutations test agreed with the family-based association results:both showed that rs916055 had a statistically significant association with PFM (P=0.033).Conclusion:rs916055 in ALOX15 gene was significantly associated with the percentage of fat mass in Chinese nuclear families with male offspring in the family-based association study using QTDT approach.

  5. 国产盐酸托莫西汀胶囊在健康人体的生物等效性%Bioequivalence of atomoxetine hydrochloride in Chinese health volunteers

    Institute of Scientific and Technical Information of China (English)

    魏计超; 刘西哲; 于洋; 侯艳宁

    2015-01-01

    Objective To establish a method for determination of atomoxetine plasma concentration by HPLC-MS/MS and study the bioavailability and bioequivalence of atomoxetine capsule in Chinese health male volunteers. Methods A randomized,two periods,crossover bioequivalence trial was designed. 24 healthy volunteers were randomly divided into two groups,and they were given a single oral dose of the tested atomoxetine capsule and reference atomoxetine capsule 20mg re-spectively. The concentrations of atomoxetine in plasma were determined by a valid LC-MS/ MS method. The pharmacokinetic parameters and relative bioavailability were processed by DAS 2. 1. 1 program to evaluate the bioequivalence of test and refer-ence capsule. Results The pharmacokinetic parameters of the test and reference capsules were as follows:Cmax were(232. 5 ± 86. 9)and(222. 8 ± 101. 1)ng/ ml;tmax were(1. 17 ± 1. 14)and(1. 27 ± 1. 09)h;t1 / 2 were(3. 55 ± 1. 33)and(3. 38 ± 1. 20)h;AUC0 - t were(1610 ± 1329)and(1575 ± 1301)ng·ml - 1 ·h - 1;AUC0 - ∞ were(1683 ± 1466)and(1634 ± 1392)ng·ml - 1 ·h - 1 ,respectively. The relative bioavailability of the test capsules was(104. 9 ± 14. 3)% . Conclusion The two preparations were bioequivalence.%目的:建立人血浆中托莫西汀浓度的 HPLC-MS/ MS 测定方法,研究国产盐酸托莫西汀胶囊在中国健康男性志愿者的主要药动学参数及与参比制剂的生物等效性。方法采用两试剂双周期交叉试验设计,24名健康受试者分别单剂量口服受试制剂和参比制剂20mg,采用 LC-MS/ MS 法测定血浆中托莫西汀的浓度,DAS 2.1.1软件计算药动学参数并考察生物等效性。结果受试制剂和参比制剂在受试者体内的药动学参数如下:Cmax 分别为(232.5±86.9)和(222.8±101.1)ng/ ml;tmax 分别为(1.17±1.14)和(1.27±1.09)h;t1/2分别为(3.55±1.33)和(3.38±1.2)h;AUC0- t分别为(1610±1329)和(1575±1301)ng·ml -1·h -1;AUC0

  6. Pharmacokinetics and Bioequivalence of Domestic Olanzapine Tablets in Healthy Chinese Volunteers%国产奥氮平片的人体药动学和生物等效性研究

    Institute of Scientific and Technical Information of China (English)

    俞凌燕; 楼洪刚; 阮邹荣; 江波; 陈金亮

    2012-01-01

    目的 评价国产奥氮平片在中国健康人体中的药动学及生物等效性.方法 采用双周期交叉试验设计,20名健康男性受试者单次口服国产和进口奥氮平片5 mg,采用LC-MS/MS测定奥氮平血药浓度,计算两制剂的主要药动学参数和生物利用度,并进行生物等效性评价.结果 国产和进口奥氮平片的主要药动学参数如下:tmax分别为(4.25±1.33)和(4.55±1.10)h,ρmax分别为(9.62±1.79)和(9.69±2.18)ng·mL-1,t1/2分别为(31.71±6.87)和(32.46±5.67)h,AUC0-t分别为(327.19±60.55)和(324.39±70.84)ng·h·mL-1,AUC0-∞分别为(354.44±74.58)和(350.70±80.94)ng·h·mL-1.受试制剂的相对生物利用度F0-t为(102.93±18.22)%,F0-∞为(103.30±20.75)%,经统计分析,各药动学参数均无显著性差异(P>0.05)结论 两种奥氮平制剂在体内过程相似,两制剂人体生物等效,临床上可以替换使用.%OBJECTIVE To study the pharmacokinetics and bioequivalence of domestic olanzapine tablets in healthy Chinese volunteers. METHODS A single oral dose of 5 mg olanzapine tablets was given to 20 healthy male volunteers in a randomized cross-over study. The concentrations of olanzapine in plasma were determined by LC-MS/MS method. The pharmacokinetie parameters and relative bioavailability were calculated by DAS. Then the bioequivalence of two formulations was evaluated. RESULTS The pharmacokinetie parameters of domestic and imported formulations were as follows ;tmax (4. 25 ±1.33) and (4.55 ± 1. 10) h, pmax(9.62 ± 1.79) and (9. 69 ±2. 18) ng·mL-1, t1/2 (31.71 ±6.87) and (32.46+5.67) h, AUC0-t, ( 327. 19 ± 60. 55 ) and (324. 39 ± 70. 84) ng·h·mL-1 , and AUC 0-∞ (354.44 ±74. 58) and (350. 70 ± 80. 94) ng·h·ml-1 , respectively. The relative bioavailability was ( 102. 93 ±18. 22 ) % for F0-t and ( 103. 30 ± 20. 75 ) % for F0-x. There was no significant difference between the two preparations (P >0. 05). CONCLUSION The two preparations are bioequivalent and can

  7. 更昔洛韦分散片和胶囊在健康人体中的生物等效性%Bioequivalence of ganciclovir dispersible tablets and capsules in Chinese healthy volunteers

    Institute of Scientific and Technical Information of China (English)

    刘茜; 邓琳琳; 赵辉; 张旭; 刘洋

    2011-01-01

    目的 研究更昔洛韦分散片和胶囊在人体内的生物等效性.方法 采用双交叉随机自身对照试验设计,20名健康受试者分别单剂量口服更昔洛韦胶囊和分散片1 000 mg后,采用HPLC法测定血药浓度,DAS2.0软件计算药动学参数,并进行等效性检验.结果 更昔洛韦分散片和胶囊的主要药动学参数:pmax分别为(0.58±0.18)和(0.60±0.20)mg·L-1,Tmax分别为(3.0±0.4)和(3.2±0.4)h,t1/2分别为(4.6±1.3)和(4.6±0.8)h,AUC0-t分别为(2.8±0.8)和(3.2±1.2)mg·h·L-1,更昔洛韦分散片和胶囊的平均相对生物利用度为(96±28)%.结论 更昔洛韦分散片和胶囊在人体内生物等效.%AIM To evaluate the bioequivalence of ganciclovir dispersible tablets and capsules in Chinese healthy volunteers.METHODS In a randomized, crossover and self-controlled study, 20 male healthy volunteers were administered with a single oral dose of test and reference preparations containing 1 000 mg ganciclovir, respectively.The plasma concentrations of ganciclovir were determined by HPLC-UV.The pharmacokinetic parameters were calculated and the bioequivalence of the two preparations was evaluated by DAS software 2.0.RESULTS The main pharmacokinetic parameters of the ganciclovir dispersible tablets and capsules were as follows: pmax were (0.58 ± 0.18) and (0.60 ± 0.20) mg·L-1, τmax were (3.0 ± 0.4) and (3.2 ± 0.4) h, t1/2 were (4.6 ± 1.3) and (4.6 ± 0.8) h, AUC0-t were (2.8 ± 0.8) and (3.2 ± 1.2) mg·h·L-1.The relative bioavailability of ganciclovir dispersible tablets was (96 ± 28) %.CONCLUSION Ganciclovir dispersible tablets and capsules are bioequivalent.

  8. 盐酸西替利嗪咀嚼片的人体生物等效性%Study on bioequivalence of cetirizine hydrochioride chewable tablets in Chinese healthy volunteers

    Institute of Scientific and Technical Information of China (English)

    温预关; 廖日房; 李佑辉; 马崔

    2009-01-01

    目的:对国产盐酸西替利嗪咀嚼片和普通片进行生物等效性考察.方法:20名健康男性志愿者按2×2交叉试验方案设计,分别口服受试制剂和参比制剂各10 mg,并采集36 h内动态血标本;采用高效液相色谱-质谱法测定血浆中西替利嗪浓度,计算药动学参数,并判定两种制剂是否生物等效.结果:受试制剂和参比制剂的主要药动学参数Cmax分别为(210.0±28.3)μg·L-1和(215.3±39.2)μg·L-1,tmax分别为(1.6±0.3)h和(1.60±0.20)h,AUC0-36分别q(1 545.5±441.5)μg·L-1.h和(1 547.4±451.1)μg·L-1·h,AUC0-∞分别为(1 633.4±479.0)μg·L-1·h和(1 624.0±478.6)μ·L-1·h,t1/2(ke)分别为(9.2±3.4)和(8.4±2.0)h,两制剂主要药动学参数经对数转换后进行方差分析及双单侧t检验,并计算90%置信区间,表明两种制剂生物等效,受试制剂的人体生物利用度为(100.3±12.0)%.结论:两种制剂生物等效.%OBJECTIVE To study the bioequivalence of cetirizine hydrochloride test preparation and reference preparation in Chinese healthy volunteers. METHODS 10 mg test preparation and reference preparation were given to 20 male healthy volun-teers in randomized two-way crossover design for the pharmacokinetic and relative bioavailability study. Plasma concentrations of cetirizine was determined by HPLC/MS. RESULTS The main pharmacokinetics parameters of the two preparations were: Cmax(210.0±28.3)μg·L-1 and (215.3±39.2)μg·L-1,tmax ,(1.60±0.20)h,AUC0-36 and (1 545.5±441.5)μg·L-1hand (1 547.4±451.1)μg·L-1·h,AUC0-∞(1 633.4±479.0)μg·L-1·h and (1 624.0±478.6)μ·L-1·h,t1/2(ke)(9. 2±3. 4)and 8. 4±2. 0)h, respectively. The mean relative bioavailability of test preparation vs reference preparation were (100.3±12. 0)%. CONCLUSION The statistical analysis shows that the two prparations are bioequivalent.

  9. Study on Bioequivalence of Cefdinir Capsules in Chinese Healthy Volunteers%头孢地尼胶囊在健康人体的生物等效性研究

    Institute of Scientific and Technical Information of China (English)

    陈芬; 朱超然; 翟学佳; 冯霞; 邓桂萍; 郭卿; 蒋立芬; 吕永宁

    2015-01-01

    目的:评价健康人餐后服用两种头孢地尼胶囊的生物等效性。方法24例男性健康志愿者餐后随机交叉单剂量口服头孢地尼胶囊受试制剂或参比制剂,头孢地尼体内血药浓度采用液相色谱-质谱串联( LC-MS/MS)法测定,药动学参数及等效性采用药动学软件DAS计算和评价。结果受试制剂和参比制剂的主要药动学参数如下:AUCt分别为(4.35±1.09)和(4.12±1.22)μg��h��mL-1,AUC0-∞分别为(4.53±1.12)和(4.53±1.73)μg��h��mL-1,t1/2分别为(1.74±0.29)和(2.13±1.65) h,tmax分别为(4.44±0.86)和(4.54±1.16) h,Cmax分别为(900±250)和(876±269) ng��mL-1。结论头孢地尼胶囊受试制剂与参比制剂具有生物等效性。%Objective To evaluate postprandial pharmacokinetics and bioequivalence of two preparations of cefdinir capsules in Chinese healthy volunteers. Methods In a two-way cross-over study, 24 healthy male volunteers were divided into two groups randomly and a single dose of cefdinir capsules of test and reference preparation were administered orally, respectively.The concentration in plasma was determined by LC-MS/MS. Pharmacokinetic parameters and bioequivalence were calculated and evaluated by DAS. Results The main pharmacokinetic parameters of test and reference were as follows: AUCt (4.35±1.09) μg��h��mL-1 and (4.12±1.22) μg��h��mL-1, AUC0-∞(4.53±1.12) and (4.53±1.73) μg��h��mL-1, t1/2 (1.74±0.29) h and (2.13±1.65) h, tmax(4.44±0.86) h and (4.54 ±1.16) h, Cmax(900±250) ng��mL-1 and (876±269) ng��mL-1 . Conclusion The test and reference preparation of cefdinir capsules are bioequivalent.

  10. CAG-repeat variant in the polymerase γ gene and male infertility in the Chinese population: a meta-analysis.

    Science.gov (United States)

    Liu, Shu-Yuan; Zhang, Chang-Jun; Peng, Hai-Ying; Yao, Yu-Feng; Shi, Lei; Chen, Jin-Bao; Lin, Ke-Qin; Yu, Liang; Shi, Li; Huang, Xiao-Qin; Sun, Hao; Chu, Jia-You

    2011-03-01

    Several studies have reported a relationship between the length of the CAG-repeat in the polymerase γ (POLG) gene and male infertility. However, other studies have not reproduced this result. In our study, the POLG-CAG-repeat length was analyzed in 535 healthy individuals from six Chinese Han populations living in different provinces. The frequencies of 10-CAG alleles and genotypes were high (97.38 and 94.13%, respectively), with no significant difference among the six Chinese Han populations. Furthermore, we determined the distribution of the POLG-CAG-repeat in 150 infertile men and 126 fertile men. Our study suggested that the distributions of POLG-CAG-repeat alleles and genotypes were not significantly different between infertile (95.67 and 92.67%, respectively) and fertile men (97.22 and 94.44%, respectively). In a subsequent meta-analysis, combining our data with data from previous studies, a comparison of the CAG-repeat alleles in fertile versus infertile men showed no obvious risk for male infertility associated with any particular allele (pooled odds ratio (OR)=0.94; 95% confidence interval (CI): 0.60-1.48). The significance level was not attained with any of the following genetic models: homozygote comparison (not 10/not 10 versus 10/10: OR=1.34; 95% CI: 0.66-2.72), heterozygote comparison (10/not 10 versus 10/10: OR=1.04; 95% CI: 0.78-1.38), dominant model comparison (not 10/not 10+10/not 10 versus 10/10: OR=1.08; 95% CI: 0.79-1.47) and recessive genetic comparison (not 10/not 10 versus 10/not 10+10/10: OR=1.31; 95% CI: 0.68-2.55). In conclusion, there is no significant difference of the frequencies of POLG-CAG-repeat variants among six Chinese Han populations, and this polymorphism may not be associated with Chinese male infertility. On the basis of a meta-analysis, there is no obvious association between CAG-repeat variants of the POLG gene and male infertility.

  11. An autoregressive integrated moving average model for short-term prediction of hepatitis C virus seropositivity among male volunteer blood donors in Karachi, Pakistan

    Institute of Scientific and Technical Information of China (English)

    Saeed Akhtar; Shafquat Rozi

    2009-01-01

    AIM: To identify the stochastic autoregressive integrated moving average (ARIMA) model for short term forecasting of hepatitis C virus (HCV) seropositivity among volunteer blood donors in Karachi, Pakistan. METHODS: Ninety-six months (1998-2005) data on volunteer blood donors tested at four major blood banks in Karachi, Pakistan were subjected to ARIMA modeling. Subsequently, a fitted ARIMA model was used to forecast HCV seropositive donors for 91-96 mo to contrast with observed series of the same months. To assess the forecast accuracy, the mean absolute error rate (%) between the observed and predicted HCV seroprevalence was calculated. Finally, a fitted ARIMA model was used for short-term forecasts beyond the observed series. RESULTS: The goodness-of-fit test of the optimum ARIMA (2,1,7) model showed non- s igni f icant autocorrelations in the residuals of the model. The forecasts by ARIMA for 91-96 mo closely followed the pattern of observed series for the same months, with mean monthly absolute forecast errors (%) over 6 mo of 6.5%. The short-term forecasts beyond the observed series adequately captured the pattern in the data and showed increasing tendency of HCV seropositivity with CONCLUSION: To curtail HCV spread, public health authorities need to educate communities and health care providers about HCV transmission routes based on known HCV epidemiology in Pakistan and its neighboring countries. Future research may focus on factors associated with hyperendemic levels of HCV infection.

  12. Male reproductive health research needs and research agenda: Asian and Chinese perspective

    Institute of Scientific and Technical Information of China (English)

    Yi-FeiWANG

    1999-01-01

    Research that addresses male re-productive health should assist in the development of reproductive health programmaes and policy; identify and test new leads in nude contraceptive technology; establish effective male involvement initiatives which are likely to have a positive impact on the reproductive health of men and women; guide the allocation of health care reources to ensure cost-effectiveness of interventions; generate new knowledge, develop diagnustic technology in reproductive health and offer optimal treatment/care regimens. In considering the needs and demands of nude reproductive health research in Asia and the Pacific, the following six research topics are recommended as the priority research areas: male contraceptive technology; nude reproductive health behaviour and male adolescent reproductive health; male reproductive aging including male menopause and other diseases; male RTIs, STDs, HIV/AIDS; prevalence, management and prevention of nude infertility; environment and semen quality and other male reproductive problems. One of the major challenges now facing us is the elaburation of a comprehensive, yet realistic male reproductive health research agenda that reflect the needs and demands of Asian developing countries. To this end, to make use of an interdisciplinary approach is of strategic importance. The most creative insights and productive leads are likely to emerge from a research team that is inteldisciplinary especially in the field of reproductive health. ( Asian J Androl 1999 Jun; 1: 13-20)

  13. Genome editing reveals dmrt1 as an essential male sex-determining gene in Chinese tongue sole (Cynoglossus semilaevis)

    Science.gov (United States)

    Cui, Zhongkai; Liu, Yun; Wang, Wenwen; Wang, Qian; Zhang, Ning; Lin, Fan; Wang, Na; Shao, Changwei; Dong, Zhongdian; Li, Yangzhen; Yang, Yingming; Hu, Mengzhu; Li, Hailong; Gao, Fengtao; Wei, Zhanfei; Meng, Liang; Liu, Yang; Wei, Min; Zhu, Ying; Guo, Hua; Cheng, Christopher H. K.; Schartl, Manfred; Chen, Songlin

    2017-01-01

    Chinese tongue sole is a marine fish with ZW sex determination. Genome sequencing suggested that the Z-linked dmrt1 is a putative male determination gene, but direct genetic evidence is still lacking. Here we show that TALEN of dmrt1 efficiently induced mutations of this gene. The ZZ dmrt1 mutant fish developed ovary-like testis, and the spermatogenesis was disrupted. The female-related genes foxl2 and cyp19a1a were significantly increased in the gonad of the ZZ dmrt1 mutant. Conversely, the male-related genes Sox9a and Amh were significantly decreased. The dmrt1 deficient ZZ fish grew much faster than ZZ male control. Notably, we obtained an intersex ZW fish with a testis on one side and an ovary on the other side. This fish was chimeric for a dmrt1 mutation in the ovary, and wild-type dmrt1 in the testis. Our data provide the first functional evidence that dmrt1 is a male determining gene in tongue sole. PMID:28205594

  14. Cutural Predictors of Self-Esteem: A Study of Chinese American Female and Male Young Adults.

    Science.gov (United States)

    Tsai, Jeanne L.; Ying, Yu-Wen; Lee, Peter Allen

    2001-01-01

    Domains of cultural orientation such as language, social affiliation, and cultural pride, were examined in Chinese American college students (N=353) to see how they related to self-esteem. Cultural orientation significantly predicted self-esteem differences. Cultural predictors of self-esteem varied by gender; self-esteem was mainly related to…

  15. Polymorphisms of angiotensin-converting enzyme 2 gene confer a risk to lone atrial fibrillation in Chinese male patients

    Institute of Scientific and Technical Information of China (English)

    WANG Shu-xia; TAO Tao; FU Zhi-qing; XIE Xiang-zhu; WANG Hao; WANG Yu-tang

    2013-01-01

    Background Growing epidemiologic evidence has indicated that genetics can predispose individuals to the occurrence of lone atrial fibrillation (AF).The angiotensin-converting enzyme 2 (ACE2) gene has been established to be associated with hypertension and left ventricular hypertrophy.The objective of our study was to investigate the association of ACE2 gene polymorphisms with lone AF.Methods A total of 265 consecutive lone AF patients and 289 healthy controls were successfully investigated.The polymorphisms rs2106809 and rs2285666 were genotyped by polymerase chain reaction (PCR) and direct sequencing.A Logistic regression model was used to determine the odds ratio (OR) and 95% confidence intervals (CI) of variations of ACE2 for lone AF.Results The T allele of rs2106809 conferred an increased risk for lone AF (OR 1.24,95% CI 1.01-1.52,P=0.03) in males after adjustment for conventional risk factors.SNP at rs2285666 in males was not significantly different between AF patients and controls.No association was found between the two polymorphisms in the female population with lone AF.After (36.3±4.5) months of follow-up,the end point data were obtained:death (cardiac and noncardiac),ischemic stroke,and heart failure.In the male subgroup,the associations between rs2106809 T male carriers and combined end points including ischemic stroke,heart failure,and death in our study were of significance (OR 3.6,95% CI 1.0-13.1,P=0.04).Conclusions The results indicate that polymorphism at ACE2 gene is associated with male lone AF in a Chinese Han population.Lone AF males who carry the rs2106809 T allele are associated with adverse cardiac events.

  16. Construction of Chinese adult male phantom library and its application in the virtual calibration of in vivo measurement

    Science.gov (United States)

    Chen, Yizheng; Qiu, Rui; Li, Chunyan; Wu, Zhen; Li, Junli

    2016-03-01

    In vivo measurement is a main method of internal contamination evaluation, particularly for large numbers of people after a nuclear accident. Before the practical application, it is necessary to obtain the counting efficiency of the detector by calibration. The virtual calibration based on Monte Carlo simulation usually uses the reference human computational phantom, and the morphological difference between the monitored personnel with the calibrated phantom may lead to the deviation of the counting efficiency. Therefore, a phantom library containing a wide range of heights and total body masses is needed. In this study, a Chinese reference adult male polygon surface (CRAM_S) phantom was constructed based on the CRAM voxel phantom, with the organ models adjusted to match the Chinese reference data. CRAMS phantom was then transformed to sitting posture for convenience in practical monitoring. Referring to the mass and height distribution of the Chinese adult male, a phantom library containing 84 phantoms was constructed by deforming the reference surface phantom. Phantoms in the library have 7 different heights ranging from 155 cm to 185 cm, and there are 12 phantoms with different total body masses in each height. As an example of application, organ specific and total counting efficiencies of Ba-133 were calculated using the MCNPX code, with two series of phantoms selected from the library. The influence of morphological variation on the counting efficiency was analyzed. The results show only using the reference phantom in virtual calibration may lead to an error of 68.9% for total counting efficiency. Thus the influence of morphological difference on virtual calibration can be greatly reduced using the phantom library with a wide range of masses and heights instead of a single reference phantom.

  17. Volunteers in Education.

    Science.gov (United States)

    Cone, Richard; Johnson, Judith

    The results of nine studies evaluating the effectiveness of volunteer programs in the schools were reviewed in an attempt to answer three questions: What is the value of volunteers to schools? Why do people volunteer to work in classrooms? What is the effect of volunteering on the volunteer? The studies involved were originally intended to…

  18. Pharmacokinetics on tramadol/acetaminophen combination tablets in Chinese healthy volunteers%曲马氨酚片的人体药物动力学研究

    Institute of Scientific and Technical Information of China (English)

    戴维; 梁建英

    2009-01-01

    To stury the pharmacokinetie of tramadol and aeetaminophen in healthy volunteers. Methods Totally 20 healthy adult male volunteers participated in the study were randomly assigned to 2 treatment groups and were given respectively the dose of one and two pills by oral administration. Serum was separated and the concentrations of tramadol and acetaminophen in human serum were determined by HPLC using fluorescence and UV detector. The values of concentration were directly detected, and AUC was calculated by linear trapezoid method. Results The main pharmacokinetie parameters of tramadol and acetaminophen of 2 dosages groups were as follow: Tramadol: AUC_(0-24h)(ng · h· mL~(-1)) were 2 724. 89 ± 1 016.54 and 1 361.61 + 441. 79; AUC_(0-∞)(ng·h·mL~(-1)) were3 065.49±1 190.66 and 1 555.04±582.51; t_(max)(h) were 1.8±0.75 and 1.9±0.57; t_(t/2)(h) were 7.34±1.39and7.63±2.02; Kel(h~(-1)) were 0. 098±0. 019 and 0. 097± 0.027; Cl_r(mL · min~(-1)) were 31.84±13.65 and 30.03 ± 9.20; MRT(h) were 7.62 ± 1.07 and 7.77 ± 0.75. Acetaminophen. AUC_(0-24h)(μg · h · mL~(-1)) were 40.28 ± 10.36 and 18.37 ± 3.84 ; AUC_(0-∞)(μg · h · mL~(-1)) were 41.63 ± 10. 96 and 18. 81 ± 4.06; t_(max)(h) were 0. 9 ± 0.46 and 0. 9 ± 0. 39; t_(t/2)(h) were5.39 ± 1. 16 and 4. 96 ± 1.03; Kel(h~(-1)) were 0. 13 ± 0. 03 and 0. 15 ± 0. 03; Clr (mL · min~(-1)) were 17.17 ± 4.57 and 18.42 ± 3.89; MRT(h) were 4.86 ± 0.48 and 4.50 ± 0.53. Conclusions No significant difference in pharmacokinetic parameters, such as t_(max), t_(t/2), Ke,Cl, MRT,AUC_(0-t)/dose, AUC_(0-∞)/dose and C_(max)/dose are shown between these two dose groups and a linear pharmacokinetic is featured.%目的 测定曲马氨酚片中曲马多和对乙酰氨基酚的药动学参数.方法 采用高效液相色谱法分别测定20名健康志愿者口服曲马氨酚片(2个剂量组:1片和2片,每组10名)后血清中的药物浓度,进行药动学分析.结果 2组健康志愿者口服曲马氨酚片

  19. 硫酸氢氯吡格雷片的人体生物等效性%The bioequivalence of clopidogrel hydrogen sulfate tablets in Chinese healthy volunteers

    Institute of Scientific and Technical Information of China (English)

    舒成仁; 卫乐乐; 黄露; 黎维勇

    2012-01-01

    OBJECTIVE To study the bioequivalence of clopidogrel hydrogen sulfate tablets. METHODS 30 healthy male volunteers were administered 150 mg clopidogrel hydrogen shlfate tablets orally in a randomized crossover design. The drug concentrations in the plasma samples were determined by an HPLC-MS/MS method. With use of DAS software the pharmaco-kinetic parameters were calculated and the bioequivalence of the two preparations was evaluated. RESULTS The main pharma-cokinetic parameters of the test and reference preparations were as follows;/?, were(0. 98 ± 0. 34) h and(0. 86 ± 0. 36) h;Cmax were(8 994. 7 + 3 515. 6) ng·mL-1 and(9 677. 0±3 838. 1) ng·mL-1 ;t1/t2 were(7. ()± 2. 4) h and(7. 0+1. 8) h; AUG41-24 were (31 670. 1 ± 13 545. 7) ng·h·mL-1 and(32 887. 4 ± 14 907. 5) ng·h·mL-1; AUG were(34 096. 8 + 14 482. 3) ng·h·mL-1 and(35 550. 4+16 455.5) ng·h·mL-1. The relative bioavailability of the test tablet was(97. 7 + 16. 6)%. CONCLUSION The two preparations are bioequivalent.%目的:研究硫酸氢氯吡格雷片受试制剂与参比制剂的人体生物等效性.方法:30名健康男性志愿者随机交叉单剂量口服硫酸氢氯吡格雷试验片或对照片1 50 mg,采用高效液相色谱-串联质谱(HPLC-MS/MS)法测定血浆中氯吡格雷羧酸代谢产物浓度.用DAS软件计算两者的药动学参数,并评价其生物等效性.结果:受试制剂与参比制剂的tmax分别为(0.98±0.34)、(0.86±0.36) h;Cmax分别为(8 994.7±3 515.6)、(9 677.0±3 838.1)ng·mL-1;t1/2分别为(7.0±2.4)、(7.0±1.8)h;AUG0-24分别为(31 670.1±13 545.7)、(32 887.4±14 907.5)ng·h·mL-1;AUG0→∞分别为(34 096.8±14 482.3)、(35 550.4±16 455.5)ng·h·mL-1.受试制剂的相对生物利用度为(97.7±16.6)%.结论:2种制剂具有生物等效性.

  20. Dose conversion coefficients for Chinese reference adult male and female voxel phantoms from idealized neutron exposures

    CERN Document Server

    Liu, Huan; Qiu, Rui; Yang, Yue; Pan, Yu-Xi; Liu, Li-Ye

    2015-01-01

    A new set of fluence-to-dose conversion coefficients based on the Chinese reference adult voxel phantoms CRAM and CRAF are presented for six idealized external neutron exposures from 10-8 MeV to 20 MeV. The voxel phantoms CRAM and CRAF were adjusted from the previous phantoms CNMAN and CNWM respectively, and the masses of individual organs have been adjusted to the Chinese reference data. The calculation of organ-absorbed doses and effective doses were performed with the Monte Carlo transport code MCNPX. The resulting dose conversion coefficients were compared with those published in ICRP Publication 116, which represents the reference Caucasian. The organ-absorbed dose conversion coefficients of most organs are in good agreement with the results in ICRP Publication 116, however, obvious discrepancies are observed for some organs and certain geometries. For neutrons with energies above 2 MeV, the effective dose conversion coefficients of Chinese reference adult are almost identical to those of ICRP Publicatio...

  1. Phthalates in Commercial Chinese Rice Wines: Concentrations and the Cumulative Risk Assessment to Adult Males in Shanghai.

    Science.gov (United States)

    Huang, Yue; Lu, Wen Wei; Chen, Bo; You, Jie; Wu, Min; Li, Shu Guang

    2014-10-01

    The concentrations of 16 phthalates in 164 commercial Chinese rice wines (CRW) were detected by GC-MS, and consumption data on CRW in different packaging types was investigated from 634 adult males in Shanghai using a food frequency questionnaire. Based on the principles of probabilistic modelling and cumulative risk assessment, the exposure and health risk of phthalates from CRW to adult males in Shanghai was evaluated. DMP, DEP, DIBP, DnBP, BBP, and DEHP were detected in the samples, the range of detection frequency of individual phthalates varied from 6.10% for BBP to 15.24% for DIBP, and the detected concentrations were 51.06-200.34 ng/mL. All the respondents consumed CRW, 90.69% of them consumed CRW 0.01-49.9 mL/d, the minimum value of the average daily intake of CRW was 6.25 mL/d, the median was 13.72 mL/d and the maximum was 300 mL/d. The median exposure level of the 6 detected Phthalates to adult males in Shanghai were 6.58-7.10 ng/(d•kg), and the maximum exposure level were 137.38-540.47 ng/(d•kg). The cumulative exposure health risk index (HI) based on the median and maximum exposure level of the 6 Phthalates (DMP, DEP, DIBP, DnBP, BBP, and DEHP) were 0.001147 and 0.063396, both were far less than 1. In conclusion, CRW were generally consumed by the adult males in Shanghai, although multiple phthalates were detected in commercial CRW, health risk of such exposure levels from commercial CRW to the target adult males in Shanghai was very low.

  2. Why Volunteer? Understanding Motivations for Student Volunteering

    Science.gov (United States)

    Holdsworth, Clare

    2010-01-01

    The profile of volunteering in English Higher Education (HE) has been enhanced in recent years through various initiatives that have not only funded activities, but have sought to expand the range of volunteering opportunities available to students and recognise the contribution that volunteering can make to students' employability. This expansion…

  3. Volunteering and Volunteers: Benefit-Cost Analyses

    Science.gov (United States)

    Handy, Femida; Mook, Laurie

    2011-01-01

    This article examines the phenomenon of volunteering from a benefit-cost perspective. Both the individual making a decision to volunteer and the organization making a decision to use volunteer labor face benefits and costs of their actions, yet these costs and benefits almost always remain unarticulated, perhaps because the common perception of…

  4. 盐酸伊伐布雷定片人体药动学研究%Pharmacokinetics of ivabradine in Chinese healthy volunteers

    Institute of Scientific and Technical Information of China (English)

    郑丽云; 郭歆; 余鹏; 刘智; 马岳惠; 尹援华; 罗茜; 程泽能

    2013-01-01

    目的:研究盐酸伊伐布雷定片在中国健康志愿者中的单次及连续多次给药药动学特征.方法:12例受试者采用随机开放二重3×3拉丁方试验设计,研究单次及连续多次给药药动学特征;采用LC MS/MS法测定血浆中伊伐布雷定及其活性代谢产物S-18982的药物浓度.药动学参数采用WinNonlin软件计算.结果:单次(5、10、15 mg)给药后伊伐布雷定的主要药动学参数:Cmax分别为(19±10)、(47±24)、(79±41) μg/L,tmax分别为(0.7±0.5)、(0.6±0.3)、(0.5±0.1)h;AUGast分别为(58±32)、(138±83)、(189±115) μg·h·L-1;AUCinf分别为(59±32)、(140±84)、(191±116) μg·h·L-1;其活性代谢产物S-18982的主要药动学参数:Cmax分别为(3.1±1.2)、(7.9±2.8)、(15.0±5.4) μg/L;tmax分别为(1.1±0.8),(0.8±0.4),(0.6±0.1)h;AUQlast分别为(17±8)、(47±19)、(76±29) μg·h·L-1;AUCinf分别为(20±8)、(52±21),(85±30) μg·h·L-.连续多次给药5 mg后伊伐布雷定的主要药动学参数:Cmax(20±7)μg/L; tmax(1.0±0.7) h; AUClast(67±32) μg·h·L-1;AUCmf(69±33) μg· h· L-1;其活性代谢产物S-18982的主要药动学参数:Cmax(4.5±1.3)μg/L;tm.(1.1±0.8) h; AUCkt(34 ± 11) μg· h·L-1; AUCinf (39 ±13) μg·h·L-1.结论:单次5~15 mg给药后,伊伐布雷定的体内过程符合一级线性动力学过程,代谢产物S-18982的体内过程呈非线性;连续多次5 mg给药后,母药和代谢产物的血药浓度第5天可达稳态,母药在体内无蓄积,代谢产物存在蓄积现象.%AIM: To investigate the pharma cokinetics of ivabradine at single doses or multi ple doses in Chinese healthy volunteers. METH ODS : This open, random and doubled 3X3 latin clinical trial involved 12 healthy volunteers, who received three single doses and then multiple do ses. The concentration of ivabradine and its ac tive metabolite S-18982 in plasma were measured by liquid chromatography/tandem mass spec trometry and the pharmacokinetic

  5. α1A肾上腺素受体阻滞剂坦洛新在男性节育中的研究%Assessment of tamsulosin as a potential male contraceptive in healthy volunteers

    Institute of Scientific and Technical Information of China (English)

    刘运兴

    2016-01-01

    目的:探讨α1A 肾上腺素受体阻滞剂坦洛新在男性节育中的有效性和安全性。方法80名受试者随机分为2组(A 组和 B 组),按依次交叉的方式给予安慰剂和坦洛新(单次口服剂量为0.4 mg 或0.8 mg),每次给药之间有7天的间歇期。每次给药后4~6小时,评估每个受试者的射精情况,同时记录性欲和坦洛新的不良反应。结果服用0.8 mg 坦洛新后,所有受试者均发生了不射精症;服用0.4 mg 的坦洛新后,有功能的精子密度及有功能的精子总数显著减少,未出现明显的不良反应,服药前后及不同剂量各研究组均未出现性欲、性高潮的减退。结论α1A 肾上腺素受体阻滞剂坦洛新有男性抗生育的效果,可作为安全、有效、可逆的男性节育药。%Objective:To investigated the effectiveness and safety of tamsulosin as a potential male contraceptive. Methods:Eighty healthy male volunteers were enrolled. This study was in a placebo controlled,randomized and crossover de-sign. We administered placebo andtamsulosin(at a single oral dose of 0. 4mg or 0. 8mg)sequentially in a crossover manner in order to eliminate bias among drugs and doses. The volunteers were equally divided into two groups(A and B). Ejacu-latory profiles were assessed by masturbation 4 - 6 h after each administration,including conventional semen analysis and sperm count in midstream urine after ejaculation(in case of anejaculation). Libido and adverse effects of tamsulosin were onserved. Seven days after the last administration,endpoint ejaculatory profiles were evaluated in all volunteers by masturba-tion. Results:Anejaculation occurred in all subjects after taking 0. 8mg of tamsulosin. Total functional sperm count was sig-nificantly reduced in the subjects after taking 0. 4 mg of tamsulosin. All of the volunteers didn ˊt have a decrease in libido. Conclusion:Our results imply that tamsulosin has the effect of the male

  6. A rapid LC-ESI-MS/MS method for the quantitation of choline, an active metabolite of citicoline: Application to in vivo pharmacokinetic and bioequivalence study in Indian healthy male volunteers.

    Science.gov (United States)

    Sarkar, Amlan Kanti; Ghosh, Debotri; Haldar, Dhiman; Sarkar, Pradipta; Gupta, Bhaswati; Dastidar, Sujata Ghosh; Pal, Tapan Kumar

    2012-12-01

    A rapid, simple, and sensitive high performance liquid chromatography-tandem mass spectrometry method (LC-ESI-MS/MS) was developed and validated for the determination and pharmacokinetic investigation of choline (CL), active metabolite of citicoline in human plasma using metformin (MF) as IS. The chromatographic separation was performed on a reversed-phase Phenomenx Gemini C18 column with a mobile phase of methanol:water (containing 10mM ammonium formate) (9:1, v/v). The calibration curves were linear over the range of 0.05-5μg/ml. The validated LC-ESI-MS/MS method was successfully applied for the evaluation of pharmacokinetic parameters and bioequivalence study of test and reference control release (CR) tablet preparation of citicoline 1000mg after a single oral administration to all 12 healthy male volunteers.

  7. Surveys of serum reproductive hormone levels and the prevalence rates of late onset of hypogonadism in Chinese aging males

    Institute of Scientific and Technical Information of China (English)

    Zhou Shan-jie; Li Xian-kun; Lu Wen-hong; Liang Xiao-wei; Yuan Dong; Li Hong; Gu Yi-qun; Zhang Bao-long; Ji Yu-dang; Wang Can-gang

    2011-01-01

    Objective:To investigate the change patterns of reproductive hormones in serum of aging males and the difference among male age brackets and the prevalence rates of late onset of hypogonadism (LOH) in males in Chinese middle and aging males.Methods:Subjects included 1,498 men aged 40 to 69 from a county,and the serum reproductive hormones of 434 subjects were measured and calculated.In addition,the prevalence rates of LOH were analyzed by cut-off point of total testosterone (TT) and free testosterone (cFT),and screening scales (a questionnaire of androgen deficiency in the aging males (ADAM) and a scale of aging males' symptoms (AMS)).TT,cFT,bio-available testosterone (Bio-T),luteinizing hormone (LH),sex hormone binding globulin (SHBG),testosterone secretion index (TSI),free testosterone index (FTI),the positive rates of LOH screening,androgen deficiency rates and the clinical prevalence rates of LOH were measured or calculated.Results:The serum TT levels did not change significantly with male aging while serum LH and SHBG levels gradually increased,but cFT,Bio-T,TSI and FTI levels gradually decreased with male aging.There was very significant difference in other six parameters of reproductive hormones (P<0.01),except for serum TT among the four age brackets(P>0.05).There was no correlation between serum TT levels and aging,LH levels(P>0.05).However,there was significantly a positive correlation between serum LH,SHBG and age (P<0.01),while there were negative correlation between cFT,Bio-T,TSI,FTI and age,LH levels (P<0.01).Moreover,SHBG level was positively correlated with LH level (P<0.01).Utilizing the Questionnaire of ADAM and AMS to screen subjects aged 40 to 69 years,mean positive rates of LOH screening were 80.77% and 32.34% respectively.Mean androgen deficiency rates were 14.02% and 43.69%by using TT and cFT cut-off point.In addition,mean LOH clinical prevalence rates of subjects on positive questionnaire results were 37.85% and 15.42

  8. 雷贝拉唑在健康志愿者体内的药动学及生物利用度研究%The pharmacokinetics and bioavailability of rabeprazole in healthy Chinese volunteers

    Institute of Scientific and Technical Information of China (English)

    吴德芹; 陈安九; 王永庆; 王德旺; 张宏文; 李子艳

    2012-01-01

    Objective;To investigate the pharmacokinetics and bioavailability of rabeprazole in healthy Chinese volunteers. Methods; A total of 20 male subjects were recruited and randomly assigned at the beginning of the study to receive a single dose of rabeprazole (20 mg) administrated either intravenously or orally. Following a 7-day washout period,all subjects received another 20 mg dose via the alternate route. Intravenous dose was given in constant infusion over 30 min,and the oral dose was given in two 10 mg tablets. Results; In intravenous administration,the terminal half-life was (62.4 ± 10.7) min;the Cmax was (1 308.6 ± 266.4) ng/ml;the total body clearance was (0.21±0.05) L/min;the AUC0-T and AUCo-∞ were (99.6 ± 21.9) mg-min/L and (102.4 ± 23.3) mg-min/L,re-spectiyely. In oral administration,the half-life was (64.2 ± 15.5) min; the Cmax was (508.3 ± 180.2) ng/ml;Tmax was attained at about 229.5 min;the total body clearance was (0.31 ± 0.10) L/min;the AUC0-T and AUC0-∞ were (69.5 ± 20.0) mg·min/L and (70.6 ± 20.2) mg·min/L,respectively. Conclusion; The bioavailability of rabeprazole was estimated to be 70.1% in healthy Chinese volunteers. The total body clearance after oral administration was significantly higher than that after intravenous administration (P < 0.01).%目的:研究健康志愿者单次口服和静脉输注雷贝拉唑20 mg后药动学特征及生物利用度.方法:20名男性健康志愿者,随机分成2组.第1周期分别接受单剂量静脉输注20 mg(输注时间30 min)和单次口服给药(2片,10 mg/片);经7d清洗期后,2组志愿者接受交叉给药.结果:雷贝拉唑静脉给药后药动学参数如下:t1/2为(62.4±10.7)min,Cmax为(1 308.6±266.4)ng/ml,总清除率为(0.21±0.05)L/min,AUC0-r和AUC0-∞分别为(99.6±21.9) mg· min/L和(102.4±23.3) mg·min/L.口服给药后t1/2为(64.2±15.5)min,Cmax为(508.3±180.2) ng/ml,Tmax为229.5 min,Cl为(0.31±0.10)L/min,AUC0-r和AUC0-∞分别为(69.5±20.0) mg· min/L和(70

  9. PHARMACOKINETIC AND BIOEQUIVALENCE COMPARISON BETWEEN EXTENDED RELEASE CAPSULES OF VENLAFAXINE HYDROCHLORIDE 150MG: AN OPEN LABEL, BALANCED, RANDOMIZED-SEQUENCE, SINGLE-DOSE, TWO-PERIOD CROSSOVER STUDY IN HEALTHY INDIAN MALE VOLUNTEERS

    Directory of Open Access Journals (Sweden)

    I.Sarath chandiran

    2011-03-01

    Full Text Available This bioequivalence study was designed to determine the pharmacokinetic, bioavailability and bioequivalence of Venlafaxine HCl 150 mg Extended Release Capsules in comparison with Effexor®-XR 150mg Extended Release Capsules after single dose administration under fed conditions in 20 healthy adult male subjects. Therefore the design of an open label, balanced, randomized, two-sequence, single dose, two way crossover study with a washout period of at least 7 days was used.Each volunteer received a 150 mg capsule of the reference or test drug respectively. On the day of dosing, blood samples were collected before dosing and at various time points up to 72 hours after dosing. Analysis of venlafaxine and its metabolite O-Desmethylvenlafaxine concentrations was performed using a validated liquid chromatography with tandem mass spectrometry (LC-MS/MS method. The pharmacokinetic parameters including Cmax, AUC0-t, AUC0-inf, Tmax, t1/2 and Kel were analyzed using the non-compartmental model. Drug safety and tolerability were assessed.The pharmacokinetic parameters including Cmax, AUC0-t, AUC0-inf, Tmax, t1/2 and Kel were analyzed using the non-compartmental model. Drug safety and tolerability were assessed. The primary pharmacokinetic parameters (Cmax, AUC0-t and AUC0-inf 90%CI were within the 80 to 125% interval required for bioequivalence as stipulated in the current regulations of the USFDA acceptance criteria. The geometric mean ratios (Test/Reference between the two products of extended-release venlafaxine capsule under fed condition were 104.91% (92.86%-118.53% and 114.41% (103.43%-124.55% for Cmax ratios, 102.24% (95.95%-108.94% and 105.27% (96.76%-114.53% for AUC0-t ratios and 101.66% (95.73%-107.97% and 104.71% (96.13%-114.05% for AUC0-inf ratios of Venlafaxine and its metabolite O-Desmethylvenlafaxine (ODV respectively. 20 volunteers had completed both treatment periods. There was no significant difference of the Tmax parameter between the two

  10. Effects of ZK 93,426, a beta-carboline benzodiazepine receptor antagonist on night sleep pattern in healthy male volunteers.

    Science.gov (United States)

    Duka, T; Goerke, D; Fichte, K

    1995-01-01

    The beta-carboline ZK 93,426, a benzodiazepine-antagonist with weak inverse agonist activity, was administered intravenously to human volunteers at a dose of 0.04 mg/kg when they initially reached slow-wave sleep during their night's sleep. Eight subjects, subjected to half a night of sleep withdrawal, took part in the study, which was performed according to a double-blind, placebo-controlled, cross-over design. Sleep parameters as determined by electroencephalography, actometry (wrist actometer) and temperature (rectal thermometer) were monitored for the whole night. Vital functions (blood pressure and heart rate) as well as subjectively experienced effects via visual analogue scales were evaluated and blood samples for hormone plasma level estimation were taken before and after sleep. ZK 93,426 was well tolerated. Sleep parameters were reduced under the influence of the drug indicating a stimulant effect. Slow wave sleep (sleep stages 3 and 4) was significantly reduced in favour of light sleep stages 1 and 2 during the first 30 min after the administration of ZK 93,426 (P = 0.02). In keeping with these findings subjects exhibited a significantly (P < 0.02) elevated number and intensity of movements during the first 90 min after the beta-carboline injection. Effects on self-ratings, in body temperature and on hormonal changes were not found. It is assumed that the benzodiazepine-antagonist ZK 93,426 is able to induce activation and disturb sleep via modulation of GABAergic transmission mainly by benzodiazepine receptor blocking properties.(ABSTRACT TRUNCATED AT 250 WORDS)

  11. An overview of male reproductive studies of boron with an emphasis on studies of highly exposed Chinese workers

    DEFF Research Database (Denmark)

    Scialli, Anthony R; Bonde, Jens Peter; Brüske-Hohlfeld, Irene;

    2010-01-01

    Boron treatment of rats, mice, and dogs has been associated with testicular toxicity, characterized by inhibited spermiation at lower dose levels and a reduction in epididymal sperm count at higher dose levels. The no-adverse-effect level for reproductive effects in male rats is 17.5mg B/kg bw....../day. Earlier studies in human workers and populations have not identified adverse effects of boron exposure on fertility, but outcome measures in these studies were relatively insensitive, based mainly on family size and did not include an evaluation of semen end points. A recent study of nearly 1000 men...... working in boron (B) mining or processing in Liaoning province in northeast China has been published in several Chinese and a few English language papers. This study included individual assessment of boron exposure, interview data on reproductive experience and semen analysis. Employed men living...

  12. The Association between Polymorphism of CARD8 rs2043211 and Susceptibility to Arteriosclerosis Obliterans in Chinese Han Male Population

    Directory of Open Access Journals (Sweden)

    Kun Zhang

    2017-01-01

    Full Text Available Background and aims: Cholesterol crystals have been shown to cause inflammation. As a response to cholesterol crystal accumulation, the NLRP3 inflammasome is activated to produce IL-1β which eventually leads to atherosclerotic lesions. As a part of innate immunity, CARD8 is involved in the modulation of above mentioned inflammatory activities. The primary objective of this study was to investigate the association between polymorphism of CARD8 rs2043211 and susceptibility to arteriosclerosis obliterans (ASO in Chinese Han male population. Methods: 758 male arteriosclerosis obliterans patients and 793 male controls were genotyped for rs2043211 with the TaqMan allele assays. Fasting blood-glucose (FBG, total cholesterol (TC, triglycerides (TG, urea nitrogen, creatinine, Serum uric acid, high density lipoprotein, low density lipoprotein, ALT, AST, and IL-1β in the blood were detected for all subjects. Clinical data were recorded to analyze the genotype-phenotype. Independent samples t-test was used to perform the comparisons between two groups. Odds ratios (ORs with 95% confidence intervals (CIs were calculated to measure the strength of relationship in the genotype distribution and allele frequencies between patients and controls. The analysis of variance was used for a genotype-phenotype analysis of the ASO patients. Results: The genotypic and allelic frequencies in the ASO group were significantly different from that in the control group (P = 0.014 by genotype, P = 0.003 by allele. Those carrying the genotype TT had a higher risk for ASO than those carrying the genotype AA (OR = 1.494, 95%CI1.131-1.974, P = 0.005.The difference was also significant after the adjustment for the history of smoking, TC, LDL, fasting blood glucose, systolic blood pressure and BMI(OR = 1.525, 95%CI1.158-2.009, P = 0.003. Conclusion: Our finding suggests that the polymorphism of CARD8 rs2043211 is probably associated with the development of ASO in Chinese Han male

  13. Pharmacokinetics of doxapram in Chinese Hui and Han healthy volunteers%多沙普仑在中国回族和汉族健康人体内的药动学

    Institute of Scientific and Technical Information of China (English)

    肖勇; 程佳; 郭涛; 夏东亚; 郑谊; 郭红亮

    2011-01-01

    Objective:To investigate the pharmacokinetics of doxapram in Chinese Hui and Han healthy volunteers. Methods:Ten Hui volunteers and ten Han volunteers were given a single dose of 50 mg doxapram by intravenous infusion. The concentration of doxapram in plasma was determined by HPLC method, and the pharmacokinetic parameters were calculated by DAS 2. 0 software. ResultS:The main pharmacokinetic parameters of Hui volunteers were as follows: cmax 48±0. 46) μg/ml, t1/2β(3. 91±2.05) h,Vd(l. 35±0.45) L/kg,AUC0-12 (3. 02±0. 56)μg · h · ml-1 ,AUC0-∞(3. 49 + 0. 73) μg · h · ml-1. The main pharmacokinetic parameters of Han volunteers were as follows: cmax( 55±0. 52) μg/ml,t1/2β(3. 87 + 2. 17) h,Vd(l. 35± 0. 96) L/kg,AUC0-12(3. 51±1. 26)μg· h · ml-1, AUC0-∞ (4. 06±l. 44) μg · h· ml-1. Conclusion:There were no significant differences in the pharmacokinetic parameters of doxapram between Chinese Hui and Han healthy volunteers.%目的:研究汉族和回族健康受试者单次静脉滴注盐酸多沙普仑后的药动学.方法:回族和汉族健康受试者各10名,单次静脉滴注盐酸多沙普仑50 mg,定时采血,用HPLC法测定多沙普仑血药浓度,DAS 2.0软件计算药动学参数.结果:回族受试者的主要药动学参数为:cmax(1.48±0.46) μg/ml、t1/2β(3.91±2.05) h、Vd(1.35±0.45) L/kg、AUC0~12(3.02±0.56) μg·h·ml-1、AUC0~∞(3.49±0.73) μg·h·ml-1.汉族受试者的主要药动学参数为:cmax(1.55±0.52) μg/ml、t1/2β(3.87±2.17) h、Vd(1.35±0.96) L/kg、AUC0~12(3.51±1.26) μg·h·ml-1、AUC0~∞(4.06±1.44) μg·h·ml-1.结论:经统计学分析,回族和汉族健康受试者单次静脉滴注盐酸多沙普仑后药动学参数的差异无统计学意义.

  14. Polymorphisms of alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 and esophageal cancer risk in Southeast Chinese males

    Institute of Scientific and Technical Information of China (English)

    Jian-Hua Ding; Su-Ping Li; Hai-Xia Cao; Jian-Zhong Wu; Chang-Ming Gao; Ping Su; Yan-Ting Liu; Jian-Nong Zhou; Jun Chang; Gen-Hong Yao

    2009-01-01

    AIM: To evaluate the impact of alcohol dehydrogenase-2 (ADH2) and aldehyde dehydrogenase-2 (ALDH2) polymorphisms on esophageal cancer susceptibility in Southeast Chinese males. METHODS: Two hundred and twenty-one esophageal cancer patients and 191 healthy controls from Taixing city in Jiangsu Province were enrolled in this study. ADH2 and ALDH2 genotypes were examined by polymerase chain reaction and denaturing highperformance liquid chromatography. Unconditional logistic regression was used to calculate the odds ratios (OR) and 95% confidence interval (CI). RESULTS: The ADH G allele carriers were more susceptible to esophageal cancer, but no association was found between ADH2 genotypes and risk of esophageal cancer when disregarding alcohol drinking status. Regardless of ADH2 genotype, ALDH2G/A or A/A carriers had significantly increased risk of developing esophageal cancer, with homozygous individuals showing higher esophageal cancer risk than those who were heterozygous. A significant interaction between ALDH2 and drinking was detected regarding esophageal cancer risk; the OR was 3.05 (95% CI: 1.49-6.25). Compared with non-drinkers carrying both ALDH2 G/G and ADH2 A/A, drinkers carrying both ALDH2 A allele and ADH2 G allele showed a significantly higher risk of developing esophageal cancer (OR = 8.36, 95% CI: 2.98-23.46).CONCLUSION: Both ADH2 G allele and ALDH2 A allele significantly increase the risk of esophageal cancer development in Southeast Chinese males. ALDH2 A allele significantly increases the risk of esophageal cancer development especially in alcohol drinkers. Alcohol drinkers carrying both ADH2 G allele and ALDH2 A allele have a higher risk of developing esophageal cancer.

  15. Association of Sleep Duration, Sleep Quality and Shift-Work Schedule in Relation to Hypertension Prevalence in Chinese Adult Males: A Cross-Sectional Survey

    Science.gov (United States)

    Lu, Kai; Chen, Jia; Wang, Li; Wang, Changying; Ding, Rongjing; Wu, Shouling; Hu, Dayi

    2017-01-01

    Background: Previous studies indicated that measurement of sleep only by duration and quality may be biased. This study aimed to investigate the interactive association of self-reported sleep duration, quality and shift-work schedule with hypertension prevalence in Chinese adult males. Methods: A total of 4519 Chinese adult males (≥18 years) were enrolled into the cross-sectional survey. Sleep attributes were measured from the responses to the standard Pittsburgh Sleep Quality Index and relevant questions in a structured questionnaire survey. The association of sleep duration, quality and shift-work schedule with hypertension prevalence was analyzed using multivariate logistic regression, considering the interaction between them or not. Results: Taking the potential interaction of the three aspects of sleep into consideration, only short sleep duration combined with poor sleep quality was found to be related to hypertension prevalence in Chinese adult males (odds ratio (OR): 1.74, 95% confidence interval (CI): 1.31–2.31), which could be modified by occasional and frequent shift-work schedule (OR: 1.43, 95% CI: 1.05–1.95; OR: 1.97, 95% CI: 1.40–2.79). Conclusions: Short sleep duration was not associated with the prevalence of hypertension in Chinese adult males unless poor sleep quality exists, which could be further modified by shift-work schedule. Assessment of sleep by measuring sleep duration only was not sufficient when exploring the association of sleep with hypertension. PMID:28230809

  16. Social Bond and Self-Reported Nonviolent and Violent Delinquency: A Study of Traditional Low Risk, At-Risk, and Adjudicated Male Chinese Adolescents

    Science.gov (United States)

    Chan, Heng Choon Oliver; Chui, Wing Hong

    2015-01-01

    Background: Little is known about the level of social bond elements and their effects on delinquency among nonadjudicated (traditional low and at-risk school-aged) and adjudicated Chinese male adolescents. Objective: Using a large adolescent sample (N = 1,177) from Hong Kong and Macau, this study aims to distinguish the level of social bond…

  17. Floral Biology of Chinese Jujube (Ziziphus jujube Mill. I: The Formation of Microspores and Development of Male Gametes

    Directory of Open Access Journals (Sweden)

    Feng Zou

    2015-08-01

    Full Text Available Ziziphus jujube Mill is an economically important fruit tree, cultivated on marginal lands on a commercial scale, especially in China. In order to elucidate the microsporogenesis and male gametogenesis formation in Chinese jujube, a cultivar named ‘Lizao’ was employed for microscopy analysis. The results are showed that ‘Lizao’ was four ventricles in each anther and the anther wall was 4 to 5 layers. Its primary anther wall consisted of the epidermis, 1-2 layers endothecium, middle and glandular tapetum layers. The development of the anther wall conformed to the basic type. The meiosis in the microspore mother cells were belonged to a simultaneous type and most of the microspores were arranged in a tetrahedron shape in the tetrads. In the later May, the shape of pollen was a triangular germination vale with three germinal furrow and the mature pollen was of 2-cell type. Floral emergence and development lasted for 1 months-from later April to later May. Based our results, we did not find the abnormal male flower in the Z. jujube ‘Lizao’, suggesting that microsporogensis development may not be factors in the low seed production in the Z. jujube. This study provides the basis for understanding the biological mechanism regulating sexual reproduction, thus expanding the prospects for Z. jujube breeding programs and for further molecular and genetic studies of this species.

  18. A yang-promoting Chinese herbal suppository preparation enhances the antioxidant status of red cells in male human subjects.

    Science.gov (United States)

    Mak, D H F; Chiu, P Y; Poon, M K T; Ng, T T L; Chung, Y K; Lam, B Y H; Du, Y; Ko, K M

    2004-07-01

    In the 16-week pilot study, the effect of a Yang-promoting Chinese herbal suppository preparation (VI-28) on the red cell antioxidant status was examined in 31 healthy male subjects aged 41-66 years old. VI-28 treatment for 12 weeks (one suppository (0.3 g) daily for week 1-4; one every 2 days for week 5-8; one every 3 days for week 9-12) produced a time/dose-dependent alteration in red cell antioxidant status. The VI-28-induced change is characterized by a slight depletion in cellular reduced glutathione (GSH) level and a decrease in susceptibility to peroxide-induced lipid peroxidation as well as increases in catalase (CAT) and Cu-Zn-superoxide dismutase (SOD) activities. While a reversal trend of change was observed in cellular GSH level, the susceptibility to lipid peroxidation as well as the CAT activity after the cessation of treatment for 4 weeks, the SOD activity exhibited a protracted increase. The results indicate that VI-28 treatment enhances red cell antioxidant status in male subjects. The beneficial effect of VI-28 treatment on red cells may re fl ect a corresponding change in antioxidant status of peripheral tissues.

  19. Pharmacokinetics of high-dose buprenorphine following single administration of sublingual tablet formulations in opioid naïve healthy male volunteers under a naltrexone block.

    Science.gov (United States)

    McAleer, Sarah D; Mills, Richard J; Polack, Torsten; Hussain, Tanweer; Rolan, Paul E; Gibbs, Alan D; Mullins, Frank G P; Hussein, Ziad

    2003-10-24

    Sublingual buprenorphine formulations have been developed as treatments for opioid dependence. In three studies, opioid naïve healthy male subjects received Subutex tablets (buprenorphine 2 and 8 mg [N=27] or 12 and 16 mg [N=27]) or Suboxone (two formulations) tablets (buprenorphine 8 mg/naloxone 2 mg [N=36]) sublingually, under a naltrexone block for assessment of buprenorphine pharmacokinetics and tablet disintegration times. Plasma buprenorphine was quantified up to 72 h post-dose using a sensitive LC-MS/MS assay. Mean Cmax values ranged from 1.6 to 6.4 ng/ml and tmax from 0.5 to 3 h. Concentrations declined bi-exponentially and fluctuations after a meal suggested enterohepatic recirculation of buprenorphine. The terminal half-life was approximately 26 h (range 9-69). Cmax and AUC appeared to increase in proportion to Subutex dose over 8-16 mg. The Suboxone formulations were bioequivalent. The least squares mean (90% CI) treatment ratio for Cmax was 1.00 (0.92-1.10) and AUC was 1.00 (0.95-1.06). Median times of disintegration were similar for all doses and formulations (range 6-12 min). Sublingual buprenorphine, up to 40 times the 400 microg analgesic dose, was well tolerated in these opioid naïve subjects, as administration of naltrexone 50-150 mg was sufficient to attenuate anticipated adverse effects in this population of subjects.

  20. Psychophysical determination of load carrying capacity for a 1-h work period by Chinese males.

    Science.gov (United States)

    Wu, S P; Chen, C C

    2001-09-15

    This study used the psychophysical approach to examine the effects of container width, the presence or absence of container handles, and different load-carrying frequencies and distances on the maximum acceptable weight carried and the resulting response (heart rate and rating of perceived exertion) by well-conditioned males for a 1-h work period. After training, 12 male subjects performed a load-carrying task at knuckle height. Each subject performed 30 different carrying combinations. The conditions examined were container width, from 15.2 to 55.9 cm; carrying frequency, from 1 carry to 5 carries/min; and carrying distance from 1 to 6 m. The results were compared with prior studies and led to the following conclusions: (1) the use of container handles leads to the subjects carrying a significantly higher maximum acceptable weight than when containers do not have handles, which differs from the results of a previous study by Morrissey and Liou; (2) there were significant reductions in the maximum acceptable carrying weight with increases in container width, frequency and distance; (3) the presence or absence of container handles, different frequencies and load-carrying distances had significant effects on heart rate, although the effect of container width was not significant. In addition, the various frequencies and distances for load carrying had significant interaction effects on heart rate; (4) the effects of various frequencies and load-carrying distances on the rating of perceived exertion were statistically significant. The most stressed body parts were the wrists and arms.

  1. Heat pain detection threshold is associated with the area of secondary hyperalgesia following brief thermal sensitization: a study of healthy male volunteers

    Science.gov (United States)

    Hansen, Morten Sejer; Wetterslev, Jørn; Pipper, Christian Bressen; Asghar, Mohammad Sohail; Dahl, Jørgen Berg

    2017-01-01

    Introduction The area of secondary hyperalgesia following brief thermal sensitization (BTS) of the skin and heat pain detection thresholds (HPDT) may both have predictive abilities in regards to pain sensitivity and clinical pain states. The association between HPDT and secondary hyperalgesia, however, remains unsettled, and the dissimilarities in physiologic properties suggest that they may represent 2 distinctively different pain entities. The aim of this study was to investigate the association between HPDT and BTS-induced secondary hyperalgesia. Methods A sample of 121 healthy male participants was included and tested on 2 separate study days with BTS (45°C, 3 minutes), HPDT, and pain during thermal stimulation (45°C, 1 minute). Areas of secondary hyperalgesia were quantified after monofilament pinprick stimulation. The pain catastrophizing scale (PCS) and hospital anxiety and depression scale (HADS) were also applied. Results A significant association between HPDT and the size of the area of secondary hyperalgesia (p<0.0001) was found. The expected change in area of secondary hyperalgesia due to a 1-degree increase in HPDT was estimated to be −27.38 cm2, 95% confidence interval (CI) of −37.77 to −16.98 cm2, with an R2 of 0.19. Likewise, a significant association between HADS-depression subscore and area of secondary hyperalgesia (p=0.046) was found, with an estimated expected change in secondary hyperalgesia to a 1-point increase in HADS-depression subscore of 11 cm2, 95% CI (0.19–21.82), and with R2 of 0.03. We found no significant associations between secondary hyperalgesia area and PCS score or pain during thermal stimulation. Conclusion HPDT and the area of secondary hyperalgesia after BTS are significantly associated; however, with an R2 of only 19%, HPDT only offers a modest explanation of the inter-participant variation in the size of the secondary hyperalgesia area elicited by BTS. PMID:28184167

  2. Effect of the potent CYP2D6 inhibitor sarpogrelate on the pharmacokinetics and pharmacodynamics of metoprolol in healthy male Korean volunteers.

    Science.gov (United States)

    Cho, Doo-Yeoun; Bae, Soo Hyeon; Lee, Joeng Kee; Park, Jung Bae; Kim, Yang-Weon; Lee, Sukhyang; Oh, Euichaul; Kim, Bom-Taeck; Bae, Soo Kyung

    2015-03-01

    1. Recently, we demonstrated that sarpogrelate is a potent and selective CYP2D6 inhibitor in vitro. Here, we evaluated the effect of sarpogrelate on the pharmacokinetics and pharmacodynamics of metoprolol in healthy subjects. 2. Nine healthy male subjects genotyped for CYP2D6*1/*1 or *1/*2 were included in an open-label, randomized, three treatment-period and crossover study. A single oral dose of metoprolol (100 mg) was administered with water (treatment A) and sarpogrelate (100 mg bid.; a total dose of 200 mg and treatment B), or after pretreatment of sarpogrelate for three days (100 mg tid.; treatment C). Plasma levels of metoprolol and α-hydroxymetoprolol were determined using a validated LC-MS/MS method. Changes in heart rate and blood pressure were monitored as pharmacodynamic responses to metoprolol. 3. Metoprolol was well tolerated in the three treatment groups. In treatment B and C groups, the AUCt of metoprolol increased by 53% (GMR, 1.53; 90% CI, 1.17-2.31) and by 51% (1.51; 1.17-2.31), respectively. Similar patterns were observed for the increase in Cmax of metoprolol by sarpogrelate. However, the pharmacodynamics of metoprolol did not differ significantly among the three treatment groups. 4. Greater systemic exposure to metoprolol after co-administration or pretreatment with sarpogrelate did not result in clinically relevant effects. Co-administration of both agents is well tolerated and can be employed without the need for dose adjustments.

  3. Effects of nanoscale quantum dots in male Chinese loaches (Misgurnus anguillicaudatus):Estrogenic interference action,toxicokinetics and oxidative stress

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Quantum dots (QDs) have received more and more attention as a novel example of nanocrystals due to their unique fluorescent characteristics. Recently, the toxicity and the potential environmental effects of QDs have become a research hotspot. In this work, in vivo endocrine disrupting effect, toxicokinetics and oxidative stress of QDs were characterized following the intraperitoneal dosing in Chinese loaches. Vitellogenin (Vtg) levels induced by E2 decreased significantly when administrated with the mixture of QDs and E2, which was consistent with the observations of histopathology in testes. The release of free Cd2+ from QDs and the non-specific adsorption of E2 by QDs might be the joint factors contributing to the inhibition of Vtg expression induced by E2 in the male Chinese loaches. In the muscle, bone, intestines, blood and testis, CdSe QDs reached the maximal concentration (Cmax) in approximately 1-h postinjection and subsequently presented downtrend with the prolonged time. Whereas, there were even increasing tendencies of CdSe QDs’ concentrations in the liver and kidney. It is educible that CdSe QDs can be persistent at least for 7 days, indicating the overall half-life of CdSe QDs in the fish body is very long. The measurement of hepatic superoxide dismutase (SOD) activity and reduced glutathione (GSH) content indicate that QDs have smaller effects on the antioxidative system of the organisms compared with free Cd2+ due to the effective prevention of the release of Cd by PEG coating of QDs. The comprehensive evaluation of QDs’ toxicity in the present study provides an essential and general framework towards more focused research on the elucidation of the biological effects of QDs in vivo.

  4. Effects of nanoscale quantum dots in male Chinese Ioaches (Misgurnus anguillicaudatus): Estrogenic interference action, toxicokinetics and oxidative stress

    Institute of Scientific and Technical Information of China (English)

    LI HongCheng; LUO WenRu; TAO Yong; WU Yuan; LV XueFei; ZHOU QunFang; JIANG GuiBin

    2009-01-01

    Quantum dots (QDs) have received more and more attention as a novel example of nanocrystals due to their unique fluorescent characteristics. Recently, the toxicity and the potential environmental effects of QDs have become a research hotspot. In this work, in vivo endocrine disrupting effect, toxicokinetics and oxidative stress of QDs were characterized following the intraperitoneal dosing in Chinese Ioaches. Vitellogenin (Vtg) levels induced by E2 decreased significantly when administrated with the mixture of QDs and E2, which was consistent with the observations of histopathology in testes. The release of free Cd~(2+) from QDs and the non-specific adsorption of E2 by QDs might be the joint factors contributing to the inhibition of Vtg expression induced by E2 in the male Chinese Ioaches. In the muscle, bone, intestines, blood and testis, CdSe QDs reached the maximal concentration (Cmax) in approximately 1-h postinjection and subsequently presented downtrend with the prolonged time. Whereas, there were even increasing tendencies of CdSe ODs' concentrations in the liver and kidney. It is educible that CdSe QDs can be persistent at least for 7 days, indicating the overall half-life of CdSe QDs in the fish body is very long. The measurement of hepatic superoxide dismutase (SOD) activity and reduced glutathione (GSH) content indicate that QDs have smaller effects on the antioxidative system of the organisms compared with free Cd~(2+) due to the effective prevention of the release of Cd by PEG coating of QDs. The comprehensive evaluation of QDs' toxicity in the present study provides an essential and general framework towards more focused research on the elucidation of the biological effects of QDs in vivo.

  5. Functional Polymorphisms of the ABCG2 Gene Are Associated with Gout Disease in the Chinese Han Male Population

    Directory of Open Access Journals (Sweden)

    Danqiu Zhou

    2014-05-01

    Full Text Available Background: Gout is a common type of arthritis that is characterized by hyperuricemia, tophi and joint inflammation. Genetic variations in the ABCG2 gene have been reported to influence serum uric acid levels and to participate in the pathogenesis of gout, but no further data have been reported in the Han Chinese population. Methods: Peripheral blood DNA was isolated from 352 male patients with gout and 350 gout-free normal male controls. High-resolution melting analysis and Sanger sequencing were performed to identify the genetic polymorphisms V12M, Q141K and Q126X in the ABCG2 gene. Genotype and haplotype analyses were utilized to determine the disease odds ratios (ORs. A prediction model for gout risk using ABCG2 protein function was established based on the genotype combination of Q126X and Q141K. Results: For Q141K, the A allele frequency was 49.6% in the gout patients and 30.9% in the controls (OR 2.20, 95% confidence interval (CI: 1.77–2.74, p = 8.99 × 10−13. Regarding Q126X, the T allele frequency was 4.7% in the gout patients and 1.7% in the controls (OR 2.91, 95% CI: 1.49–5.68, p = 1.57 × 10−3. The A allele frequency for V12M was lower (18.3% in the gout patients than in the controls (29% (OR 0.55, 95% CI 0.43–0.71, p = 2.55 × 10−6. In the order of V12M, Q126X and Q141K, the GCA and GTC haplotypes indicated increased disease risk (OR = 2.30 and 2.71, respectively. Patients with mild to severe ABCG2 dysfunction accounted for 78.4% of gout cases. Conclusion: The ABCG2 126X and 141K alleles are associated with an increased risk of gout, whereas 12M has a protective effect on gout susceptibility in the Han Chinese population. ABCG2 dysfunction can be used to evaluate gout risk.

  6. Associations between sitting time and non-alcoholic fatty liver diseases in Chinese male workers: a cross-sectional study

    Science.gov (United States)

    Wei, Huili; Qu, Hua; Wang, Hang; Deng, Huacong

    2016-01-01

    Objectives Various studies have revealed a close association between sedentary behaviour and metabolic diseases, yet the association between sedentary time and non-alcoholic fatty liver disease (NAFLD) remains unclear. In this study, we investigated the association between sitting time and NAFLD in a Chinese male population and explored its underlying mechanism. Study design A cross-sectional study. Setting Chongqing, China. Participants Our study included 2054 male participants; all of the participants were of Han nationality. Primary outcome measures Sitting time was assessed using a self-reported questionnaire concerning the time devoted to sitting behaviour. Various clinical and demographic biomarkers were measured. Logistic regression analyses were used to investigate the ORs and the 95% CIs between sitting time and NAFLD. Results We found a higher proportion of NAFLD across the tertiles of sitting time (p trend=0.003). Multivariate linear regression analyses showed sitting time independently correlated with homoeostasis model assessment for insulin resistance (HOMA-IR), alanine aminotransferase, γ-glutamyl transpeptidase, body mass index, triglyceride and the high-sensitive C reactive protein (hsCRP) (all p7.1 hours/day) was associated with a higher prevalence of NAFLD (OR 1.09; 95% CI (1.04 to 1.67)) after adjusting for confounders. However, this association was insignificant after further adjusting for hsCRP (OR 1.03; 95% CI (0.92 to 1.84)). Conclusions Sitting time was positively associated with the prevalence of NAFLD, and this association might be affected by inflammation. PMID:27609847

  7. Distribution pattern of left-ventricular myocardial strain analyzed by a cine MRI based deformation registration algorithm in healthy Chinese volunteers

    Science.gov (United States)

    Liu, Hong; Yang, Dan; Wan, Ke; Luo, Yong; Sun, Jia-Yu; Zhang, Tian-Jing; Li, Wei-Hao; Greiser, Andreas; Jolly, Marie-Pierre; Zhang, Qing; Chen, Yu-Cheng

    2017-01-01

    The cine magnetic resonance imaging based technique feature tracking-cardiac magnetic resonance (FT-CMR) is emerging as a novel, simple and robust method to evaluate myocardial strain. We investigated the distribution characteristics of left-ventricular myocardial strain using a novel cine MRI based deformation registration algorithm (DRA) in a cohort of healthy Chinese subjects. A total of 130 healthy Chinese subjects were enrolled. Three components of orthogonal strain (radial, circumferential, longitudinal) of the left ventricle were analyzed using DRA on steady-state free precession cine sequence images. A distinct transmural circumferential strain gradient was observed in the left ventricle that showed universal increment from the epicardial to endocardial myocardial wall (epiwall: −15.4 ± 1.9%; midwall: −18.8 ± 2.0%; endowall: −22.3 ± 2.3%, P < 0.001). Longitudinal strain showed a similar trend from epicardial to endocardial layers (epiwall: −16.0 ± 2.9%; midwall: −15.6 ± 2.7%; endowall: −14.8 ± 2.4%, P < 0.001), but radial strain had a very heterogeneous distribution and variation. In the longitudinal direction from the base to the apex of the left ventricle, there was a trend of decreasing peak systolic longitudinal strain (basal: −23.3 ± 4.6%; mid: −13.7 ± 7.3%; apical: −13.2 ± 5.5%; P < 0.001). In conclusion, there are distinct distribution patterns of circumferential and longitudinal strain within the left ventricle in healthy Chinese subjects. These distribution patterns of strain may provide unique profiles for further study in different types of myocardial disease. PMID:28349989

  8. Effect of Dynamic Platform Lateral Step-Up versus Stable Platform Lateral Step-Up Weight Bearing Exercise in Hip Abductor Strengthening on Healthy Male Volunteers - Randomized Clinical Trial

    Directory of Open Access Journals (Sweden)

    Jagatheesan Alagesan

    2011-07-01

    Full Text Available Objective & Background: To determine the effect of the dynamic platform lateral step-up and stable platform lateral step-up weight bearing standing exercise in strengthening of hip abductor. Many researchers have reported that strengthening of hip muscles as important component especially hip abductors in lower extremity rehabilitation program. Study Design: Single blinded randomized comparative clinical trial. Methodology: Sixty five healthy college going male subjects (Age group of 18 – 24 years volunteered for this study. They were randomly assigned to one of the 2 groups. One group received the dynamic platform lateral step-up and the other received stable platform lateral step-up weight bearing standing exercise. The strength measurements were recorded using hand held dynamometer. Results: The results indicate that both groups had a positive effect on the outcome measures. The strength of hip abductors in dynamic platform group improved from a mean value (SD of 19.47(3.59 to 26.93(3.19 and in stable platform group from 19.07(2.32 to 22.67(2.46. Significant difference is also observed between the two groups at p value .05. Conclusion: The study shows that dynamic platform lateral step-up exercise is more beneficial than stable platform lateral step-up weight bearing standing exercise in improving hip abductor muscle strength.

  9. Volunteering, income and health

    Science.gov (United States)

    Detollenaere, Jens; Willems, Sara

    2017-01-01

    Separate literatures have related volunteering to health gains and income gains. We study the association between volunteering, income and health within one statistical framework. A state-of-the-art mediation analysis is conducted on data concerning the health, volunteering and sociodemographic characteristics of 42926 individuals within 29 European countries. We find that volunteering is positively associated to self-rated health. This association is partially mediated by household income. PMID:28273163

  10. Intergenerational Transmission of Volunteering

    NARCIS (Netherlands)

    Bekkers, René

    2007-01-01

    In this article, I investigate the strength of intergenerational transmission of volunteering for non-profit associations in The Netherlands. Data from the Family Survey of the Dutch Population 2000 reveal that there are significant relations between current volunteering and parental volunteering in

  11. My Volunteer Life

    Institute of Scientific and Technical Information of China (English)

    FengAi

    2004-01-01

    SEVERAL years ago, I read a notice soliciting volunteer teachers to work in the west.It caught my interest and I clipped it. Upon graduation in August 2000, 1 postponed my graduate stud-ies in sociology and joined the Fudan Team of China Youth Volunteer Aid.My one-year volunteer life began in

  12. Kinetics of di(2-ethylhexyl) phthalate (DEHP) and mono(2-ethylhexyl) phthalate in blood and of DEHP metabolites in urine of male volunteers after single ingestion of ring-deuterated DEHP

    Energy Technology Data Exchange (ETDEWEB)

    Kessler, Winfried, E-mail: kessler@helmholtz-muenchen.de [Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, D-85764 Neuherberg (Germany); Numtip, Wanwiwa [Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, D-85764 Neuherberg (Germany); Völkel, Wolfgang; Seckin, Elcim [Department of Chemical Safety and Toxicology, Bavarian Health and Food Safety Authority, Pfarrstrasse 3, D-80538 München (Germany); Csanády, György A. [Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, D-85764 Neuherberg (Germany); Institut für Toxikologie und Umwelthygiene, Technische Universität München, München (Germany); Pütz, Christian [Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, D-85764 Neuherberg (Germany); and others

    2012-10-15

    The plasticizer di(2-ethylhexyl) phthalate (DEHP) is suspected to induce antiandrogenic effects in men via its metabolite mono(2-ethylhexyl) phthalate (MEHP). However, there is only little information on the kinetic behavior of DEHP and its metabolites in humans. The toxikokinetics of DEHP was investigated in four male volunteers (28–61 y) who ingested a single dose (645 ± 20 μg/kg body weight) of ring-deuterated DEHP (DEHP-D{sub 4}). Concentrations of DEHP-D{sub 4}, of free ring-deuterated MEHP (MEHP-D{sub 4}), and the sum of free and glucuronidated MEHP-D{sub 4} were measured in blood for up to 24 h; amounts of the monoesters MEHP-D{sub 4}, ring-deuterated mono(2-ethyl-5-hydroxyhexyl) phthalate and ring-deuterated mono(2-ethyl-5-oxohexyl) phthalate were determined in urine for up to 46 h after ingestion. The bioavailability of DEHP-D{sub 4} was surprisingly high with an area under the concentration-time curve until 24 h (AUC) amounting to 50% of that of free MEHP-D{sub 4}. The AUC of free MEHP-D{sub 4} normalized to DEHP-D{sub 4} dose and body weight (AUC/D) was 2.1 and 8.1 times, that of DEHP-D{sub 4} even 50 and 100 times higher than the corresponding AUC/D values obtained earlier in rat and marmoset, respectively. Time courses of the compounds in blood and urine of the volunteers oscillated widely. Terminal elimination half-lives were short (4.3–6.6 h). Total amounts of metabolites in 22-h urine are correlated linearly with the AUC of free MEHP-D{sub 4} in blood, the parameter regarded as relevant for risk assessment. -- Highlights: ► After DEHP intake, DEHP and MEHP in blood show oscillating time courses. ► Dose-related blood levels of DEHP are 50 times higher in humans than in rats. ► Dose-related blood levels of free MEHP are 2 times higher in humans than in rats. ► Elimination of DEHP and its metabolites is short with half-lives of 4.3-6.6 h.

  13. 大白菜雄性不育系MS200712的研究简报%Brief Report on Chinese Cabbage Male Sterile Line MS200712

    Institute of Scientific and Technical Information of China (English)

    张德双; 张凤兰; 余阳俊; 赵岫云; 于拴仓; 汪维红; 苏同兵; 卢桂香

    2014-01-01

    Creation and abortive mechanism of new male sterile lines are hot-topics on Chinese cabbage breeding.F1 hybrid crossing Brassica allohexaploid(AABBCC,n=27),which owns A,B and C chromosomes simultaneously,with Chinese cabbage variety of‘Jinchun’was obtained.Then the F1 as a male parent was crossed with Chinese cabbage variety of‘Yihe No. 5’.Thus male sterile MS200712 was founded due to multi-parents crossing.MS200712 owned yellow petal and light-yellow anther.The anthers were regressive,which were 100% male sterility.Stigma of MS200712 was normal and nectaries were vigor. Meanwhile 832172,male parent of‘Beijingnew No. 3’was crossed with MS200712,and male sterile MS20071208-916 was obtained.%以芸薹属异源六倍体AABBCC为母本,以大白菜品种金春为父本进行杂交,获得F1(AABBCC×AA);再以大白菜品种义和5号为母本,与F1进行杂交,在多亲本杂交后代中获得大白菜雄性不育系MS200712。该不育系花瓣为黄色,花药浅黄色、退化、败育彻底,柱头正常,蜜腺发达。同时,利用北京新3号的父本832172与雄性不育系MS200712进行回交,获得了转育的MS20071208-916不育系。

  14. Volunteers in Sport Organizations

    Directory of Open Access Journals (Sweden)

    VESNA CILERDZIC

    2010-01-01

    Full Text Available The research is done in order to describe student’s attitudes on volunteering in sport. The sample consists of 231 students from Serbia, average age 21,06±3,12years. They were from eight colleges and faculties. For nominal and ordinal variables, frequencies were determined. Many of examined students have volunteering experiences. The results confirm that students believe that we live in a society which his generally thought only to its own benefit; they think that volunteering can not solve the problems in society; that people do not have enough experience with volunteering and people do not have time to volunteering; volunteering is for young people; in their family and among friends, there are no volunteers; everyone could be volunteer only if that wishes; do not believe that volunteering is a waste of time and it helps in future career. The prevalent number of students, regardless of the Faculty which they belong, rarely volunteered in areas outside of sport. Results also shows that students from sport faculties have less experience in volunteering in sport than students from other faculties, but this difference is not dramatic.

  15. Bioequivalence assessment of meloxicam granules in Chinese healthy volunteers%美洛昔康颗粒剂的人体生物等效性评价

    Institute of Scientific and Technical Information of China (English)

    李佩琼; 林明琴; 王九辉; 吴秀琼

    2011-01-01

    Aim To evaluate the bioequivalence of meloxicam granules in healthy volunteers. Methods The randomized crossover and self-control study was conducted in 20 healthy volunteers. They were treated with a single oral dose of 15mg of meloxicam granules or a single oral dose of control drug (meloxicam tablets). The meloxicam concentrations in plasma were detected by RP-HPLC. Results The mean Tmax was (3.3 ±1.6) h for meloxicam granules and (4.7±1.1)h for meloxicam tablets;the mean Cmax was (0.652±0.109) and (0.532± 0.106)μg/mL respectively;T1/2 was(26.56±11.29)and (26.87±9.99) h respectively; AUC0 96 was (20.083±6.182) and (18.767±6.165)μg·h/mL respectively;AUC0 ∞was (23.901±8.624) and (22.452±7.548)μg·h/mL respectively;The relative bioavailability of meloxicam granules was (113.8±35.5 )%. Conclusion The meloxicam orally suspension is bioequivalent to the meloxicam tablets.%目的 评价健康人口服美洛昔康颗粒的生物等效性.方法 20名健康男性志愿者随机交叉单剂量口服美洛昔康颗粒或美洛昔康片15mg后,采用RP-HPLC紫外分析法检测血药浓度.结果美洛昔康颗粒及美洛昔康片的Tmax分别为(3.3±1.6)和(4.7±1.1)h;Cmax分别为(0.652±0.109)μg/h·mL和(0.532±0.106)μg/h·mL;T1/2分别为(26.56±11.29)h和(26.87±9.99)h;AUCo→96分别为(20.083±6.182)μg/h·mL和(18.767±6.165)μg/h·mL;AUCo→分别为(23.901±8.624)μg/h·mL和(22.452±7.548)μg/h·mL;美洛昔康颗粒的相对生物利用度F为(113.8±35.5)%.结论 美洛昔康颗粒与美洛昔康片具有生物等效性.

  16. An LC-MS/MS method for simultaneous determination of cefprozil diastereomers in human plasma and its application for the bioequivalence study of two cefprozil tablets in healthy Chinese volunteers.

    Science.gov (United States)

    Liu, Min; Ma, Jing-Yi; Zhang, Yanan; Wang, Xiaolin; Zhao, Hongna; Du, Aihua; Yang, Man; Meng, Lingjie; Deng, Ming; Liu, Huichen

    2016-03-01

    A rapid and sensitive liquid chromatography-tandem mass spectrometric method was developed for the first time and validated for the determination of cefprozil diastereomers in human plasma. The plasma samples were prepared by protein precipitation using acetonitrile. Detection was performed using an electronic spray ion source in the negative ion mode, operating in the multiple reaction monitoring of the transitions m/z 388.0 to m/z 205.0 for cefprozil diastereomers and m/z 346.1 to m/z 268.1 for cephalexin (the internal standard). The calibration curves of cis-cefprozil and trans-cefprozil were linear in the ranges 0.125-16.0 µg/mL and 0.0403-1.72 µg/mL, respectively. The lower limits of quantification of cis- and trans-cefprozil were 0.125 and 0.0403 µg/mL in human plasma, respectively. The intra- and inter-day precisions of cis- and trans-cefprozil were all bioequivalence study of two cefprozil formulations in 24 healthy Chinese volunteers. The two cefprozil tablets were bioequivalent by measurement of cis-, trans- and total cefprozil. We suggest that the bioequivalence of cefprozil formulations can be evaluated only using cis-cefprozil as the analyte in future studies.

  17. Pharmacokinetics of compound famotidine chewing tablets in Chinese healthy volunteers after a single oral dose administration%单剂量复方法莫替丁咀嚼片在健康人体的药代动力学

    Institute of Scientific and Technical Information of China (English)

    刘丽京; 李素霞; 孙莉; 邓艳萍

    2015-01-01

    Objective To evaluate the pharmacokinetics of single dose of compound famotidine chewing tablets in Chinese healthy volunteers . Methods The study was designed as an open , randomized , parallel and single-dose single cycle study .Thirty healthy volunteers were divided into three groups .The drug concentrations of plasma sample from the vo-lunteers after taking 20 , 30 and 40 mg famotidine were determined by HPLC.The pharmacokine-tic parameters were calculated by 3P97 soft-ware.Results The healthy volunteers were given single dose of famoti-dine with 20, 30 and 40 mg, respectively.The main pharmacokinetic pa-rameters were as follows:Cmax were (68.94 ±15.34 ), (100.34 ±31.95 ), (98.82 ±42.87)ng? mL-1, tmax were (1.70 ±0.42), (1.75 ±0.35), (1.60 ±0.52 ) h, t1/2Ke were (2.88 ±0.48), ( 2.86 ±0.68 ), (3.61 ±0.42)h, AUC0-15 were (345.99 ±98.99), (448.50 ±104.02 ), (478.84 ±200.98 ) ng? h? mL-1.Conclusion The plasma concentra-tion-time curve fits one compartment model .The safe dose was 20-40 mg.%目的 评价中国健康志愿者单剂量口服复方法莫替丁咀嚼片后的药代动力学. 方法 按开放、随机、平行、单次、单周期试验设计. 30名健康受试者,男女各半,分为3组,分别单次口服复方法莫替丁咀嚼片20,30,40 mg后,用HPLC法测定血浆中法莫替丁的浓度,用3 P97软件计算药代动力学参数. 结果 单剂量口服复方法莫替丁咀嚼片后,20,30,40 mg组法莫替丁的主要药代动力学参数:Cmax分别为(68.94 ±15.34),(100.34 ±31.95),(98.82 ±42.87)ng? mL-1;tmax分别为( 1.70 ±0.42 ), ( 1.75 ±0.35 ), ( 1.60 ±0.52 ) h;t1/2Ke 分别为(2.88 ±0.48), ( 2.86 ± 0.68 ), ( 3.61 ± 0.42 ) h; AUC0-15 分 别 为(345.99 ±98.99),(448.50 ±104.02 ), (478.84 ±200.98 ) ng? mL-1 ? h.结论 复方法莫替丁咀嚼片的血药浓度-时间曲线符合一室模型,其剂量在20~40 mg是安全的.

  18. Bioequivalence of two lansoprazole delayed release capsules 30 mg in healthy male volunteers under fasting, fed and fasting-applesauce conditions: a partial replicate crossover study design to estimate the pharmacokinetics of highly variable drugs.

    Science.gov (United States)

    Thota, S; Khan, S M; Tippabhotla, S K; Battula, R; Gadiko, C; Vobalaboina, V

    2013-11-01

    An open-label, 2-treatment, 3-sequence, 3-period, single-dose, partial replicate crossover studies under fasting (n=48), fed (n=60) and fasting-applesauce (n=48) (sprinkled on one table spoonful of applesauce) modalities were conducted in healthy adult male volunteers to evaluate bioequivalence between 2 formulations of lansoprazole delayed release capsules 30 mg. In all the 3 studies, as per randomization, either test or reference formulations were administered in a crossover manner with a required washout period of at least 7 days. Blood samples were collected adequately (0-24 h) to determine lansoprazole plasma concentrations using a validated LC-MS/MS analytical method. To characterize the pharmacokinetic parameters (Cmax, AUC0-t, AUC0-∞, Tmax, Kel and T1/2) of lansoprazole, non-compartmental analysis and ANOVA was applied on ln-transformed values. The bioequivalence was tested based on within-subject variability of the reference formulation. In fasting and fed studies (within-subject variability>30%) bioequivalence was evaluated with scaled average bioequivalence, hence for the pharmacokinetic parameters Cmax, AUC0-t and AUC0-∞, the 95% upper confidence bound for (μT-μR)2-θσ2 WR was ≤0, and the point estimates (test-to-reference ratio) were within the regulatory acceptance limit 80.00-125.00%. In fasting-applesauce study (within-subject variability<30%) bioequivalence was evaluated with average bioequivalence, the 90% CI of ln-transformed data of Cmax, AUC0-t and AUC0-∞ were within the regulatory acceptance limit 80.00-125.00%. Based on these aforesaid statistical inferences, it was concluded that the test formulation is bioequivalent to reference formulation.

  19. Statin myalgia is not associated with reduced muscle strength, mass or protein turnover in older male volunteers, but is allied with a slowing of time to peak power output, insulin resistance and differential muscle mRNA expression.

    Science.gov (United States)

    Mallinson, Joanne E; Marimuthu, Kanagaraj; Murton, Andrew; Selby, Anna; Smith, Kenneth; Constantin-Teodosiu, Dumitru; Rennie, Michael J; Greenhaff, Paul L

    2015-03-01

    Statins are associated with muscle myalgia and myopathy, which probably reduce habitual physical activity. This is particularly relevant to older people who are less active, sarcopaenic and at increased risk of statin myalgia. We hypothesised that statin myalgia would be allied to impaired strength and work capacity in older people, and determined whether differences aligned with divergences in lean mass, protein turnover, insulin sensitivity and the molecular regulation of these processes. Knee extensor strength and work output during 30 maximal isokinetic contractions were assessed in healthy male volunteers, nine with no statin use (control 70.4 ± 0.7 years) and nine with statin myalgia (71.5 ± 0.9 years). Whole body and leg glucose disposal, muscle myofibrillar protein synthesis (MPS) and leg protein breakdown (LPB) were measured during fasting (≈5 mU l(-1) insulin) and fed (≈40 mU l(-1) insulin + hyperaminoacidaemia) euglyceamic clamps. Muscle biopsies were taken before and after each clamp. Lean mass, MPS, LPB and strength were not different but work output during the initial three isokinetic contractions was 19% lower (P < 0.05) in statin myalgic subjects due to a delay in time to reach peak power output. Statin myalgic subjects had reduced whole body (P = 0.05) and leg (P < 0.01) glucose disposal, greater abdominal adiposity (P < 0.05) and differential expression of 33 muscle mRNAs (5% false discovery rate (FDR)), six of which, linked to mitochondrial dysfunction and apoptosis, increased at 1% FDR. Statin myalgia was associated with impaired muscle function, increased abdominal adiposity, whole body and leg insulin resistance, and evidence of mitochondrial dysfunction and apoptosis.

  20. 盐酸利托君片在中国健康人体的生物等效性%Bioequivalence of ritodrine hydrochloride tablets in Chinese healthy volunteers

    Institute of Scientific and Technical Information of China (English)

    张佳丽; 吴华; 潘世芬; 王鹤尧

    2012-01-01

    目的 评价2种国产盐酸利托君片在中国健康人体的生物等效性.方法 22名健康女性受试者随机交叉单剂量口服盐酸利托君片试验药物或对照药物,各10 mg.用高效液相色谱-串联质谱法测定血浆中盐酸利托君浓度;用DAS2.0软件计算药代动力学参数,并对2种药物进行生物等效性评价.结果 试验药物和对照药物的主要药代动力学参数:Cmax分别为(5.71±1.83)和(5.61±2.03)ng·mL-1;Tmax分别为(0.54±0.45)和(0.46 ±0.24) h;t1/2分别为(3.64±3.99)和(4.25±4.02)h;AUC0-t分别为(12.31±5.20)和(12.01±5.42)h·ng·mL-1.AUC0-t、AUC0-∞、Cmax的90%可信区间分别为95.8%~111.6%、92.3% ~ 118.9%和95.4% ~ 108.2%.试验药物相对于对照药物的生物利用度F为(105.3±19.96)%.结论 试验药物和对照药物生物等效.%Objective To evaluate the bioequivalence of two preparations of ritodrine hydrochloride tablets. Methods A single oral dose of 10 mg test and reference ritodrine hydrochloride tablets were given to 22 female healthy volunteers in a randomized crossover study. The concentrations of ritodrine hydrochloride were determined by HPLC - MS /MS method. The pharmacokinetic paramters and relative bioavailability were calculated by DAS 2. 0 software, then the bioequivalence was judged. Results The main pharmacokinetic parameters of two preparations were as follows; CmaXwere (5.71 ±1.83), (5.61 ±2.03) ng · mL-1, Tmax were (0. 54 ±0. 45), (0. 46 ±0. 24) h, t1/2were(3. 64 ±3. 99), (4. 25 ±4.02) h, AUC0_t were(12. 31 ±5.20), (12.01 ±5.42) h · ng · mL -1, respectively. The relative bioavailability of test tablets was (105. 3 ± 19. 96) % . The 90% Cis for the ratios of AUC0_t, Cmax were 95. 8% - 111. 6% , 95.4% - 108. 2% , respectively. Conclusion The results demonstrated that the two preparations were bioequivalent.

  1. T allele at site 6007 of bone morphogenetic protein-4 gene increases genetic susceptibility to ossification of the posterior longitudinal ligament in male Chinese Han population

    Institute of Scientific and Technical Information of China (English)

    MENG Xiang-long; WANG Hao; YANG Hui; HAI Yong; TIAN Bao-peng; LIN Xin

    2010-01-01

    Background Several candidate genes of ossification of the posterior longitudinal ligament (OPLL) susceptibility have been identified, but their polymorphisms account for only a small percent of the total variance. Bone morphogenetic protein-4 (BMP4) is a potent ectopic ossification inducing factor. BMP4 protein and mRNA are present in cells from OPLL patients, but not non-OPLL controls. A single nucleotide polymorphism of 6007C>T(rs17563) of BMP4 has been reported to affect bone density in postmenopausal women. Thus, BMP4 may function in OPLL development. Appropriately, the relationship between BMP4 polymorphisms and OPLL was investigated.Methods A case-control association study investigated the genetic etiology in 179 OPLL patients and 298 non-OPLL controls. Extent of OPLL was analyzed by radiologic examinations. Whether single nucleotide polymorphism (SNP) of -5826G>A(rs1957860) 5′ of the transcription start site and 6007C>T(rs17563) in exon 4 of the BMP4 gene were statistically associated with genetic susceptibility to OPLL in Chinese Han subjects was assessed.Results A significant statistical difference in genotype of 6007C>T polymorphism between male OPLL patients and male controls was evident, and the frequency of "TT" genotype in male OPLL patients was significantly higher than in male controls (P=0.039). The frequency of the "T" allele was also significantly higher in male OPLL subjects than in male controls (P=0.014, 0R=1.57). A significant difference was also observed between the 6007C>T polymorphism and the number of ossified cervical vertebrae in OPLL patients, while no statistical difference was apparent between the -5826G>A polymorphism and OPLL occurrence.Conclusions The T allele in the 6007C>T polymorphism may be a risk factor for male Han Chinese with ossification of the posterior longitudinal ligament in the cervical spine. Chinese Han male patients with CT and TT 6007C>T genotypes have a genetic susceptibility to OPLL and more extensive OPLL in

  2. Validity and clinical utilization of the Chinese version of the Gotland Male Depression Scale at a men’s health polyclinic

    Directory of Open Access Journals (Sweden)

    Chu CL

    2014-09-01

    Full Text Available Chun-Lin Chu,1–3 Yu Chen,1,3,4 Kun-Hao Jiang,1,3,5 Jiun-Liang Chen,1,3,5 Chin-Pang Lee,1–3 Yeuk-Lun Chau,1,2 Ching-Yen Chen1–3 1Men’s Health Center, 2Department of Psychiatry, Chang Gung Memorial Hospital at Linkou, 3School of Medicine, Chang Gung University, 4Department of Urology, 5Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan Introduction: Symptoms of depression in males, such as aggression and irritability, are different from those in females. However, there are no adequate scales for detecting possible diagnoses in the Chinese population. The aim of this study was to assess whether the Chinese version of the Gotland Male Depression Scale (CV-GMDS could identify male depression as effectively as the English version. Materials and methods: A total of 231 male outpatients were sampled from a men’s health polyclinic. We used questionnaires to evaluate the characteristics and mood status of participants, including the CV-GMDS, the Chinese version of the Beck Depressive Inventory II (CV-BDI-II, and the Chinese version of the Aging Males’ Symptoms (CV-AMS scale. Cronbach’s α-coefficient and Levene’s test were used to investigate internal consistency and homogeneity, respectively. External validity was evaluated using Spearman’s correlation coefficient. A factor analysis was conducted to evaluate the conceptual structure of the CV-GMDS, and a regression analysis was used to determine the relationship of the CV-AMS scale with the CV-GMDS and CV-BDI-II. Results: The mean age of the 231 participants was 46.1 years (standard deviation 11.0. Of the participants, 36.8% (n=85 were found to have depression according to the CV-GMDS and 34.6% (n=80 according to the CV-BDI-II. The internal consistency of the CV-GMDS was demonstrated by a Cronbach’s α of 0.933, and the test of homogeneity revealed a P-value of 0.762. The external validity for the CV-GDMS and CV-BDI-II was demonstrated

  3. 氨酚曲马多片在中国健康志愿者体内的药动学研究%Pharmacokinetics of tramadol hydrochloride-paracetamol tablets in Chinese healthy volunteers

    Institute of Scientific and Technical Information of China (English)

    孙莉; 周芬; 范华莹; 梁军成; 刘丽京; 邓艳萍

    2011-01-01

    目的:研究氨酚曲马多片在中国健康志愿者体内的药动学.方法:12名健康志愿者,男女各半,采用3×3拉丁方设计,分别顿服氨酚曲马多片(盐酸曲马多37.5 mg+对乙酰氨基酚325 mg)1,2,3片.反相HPLC-UV法检测对乙酞酰基酚、曲马多及其代谢物Ml的含量,并采用3 P97药动学软件估算药动学参数,C_max和T_max采用实测值计算,AUC_o-tn采用梯形法计算.结果:口服不同剂量氨酚曲马多片后,对乙酰氨基酚、曲马多及其代谢物Ml药-时曲线拟合结果均符合一室模型,各剂量组的C_max和AUC_o-24随剂量增加而增大.结论:在给药剂量范围内氨酚曲马多单次给药后的C_max和AUC_o-24与剂量的线性关系尚不能得出明确结论.%Objective: To investigate the pharmacokinetics of tramadol hydrochloride-paracetamol tablets in Chinese healthy volunteers. Methods: 12 volunteers (6 men and 6 women) were divided into six groups by 3 ×3 design, and administered with single dose of 1, 2 and 3 tables in 3 cross periods. The concentrations of paracetamol, tramadol and its metabalite O-desmethyltramadol (M1) were determined by high performance liquid chromatography (HPLC). The pharmacokinetic parameters were calculated using 3P97 software. Results: The concentration-time curves of paracetamol, tramadol and M1 were described by one-compartment open model. The pharmacokinetics parameters such as Cmax and AUC0-24 were proportionally increased with doses. Conclusion: There is no clear conclusions that the process of tramadol hydrochloride-paracetamol tablets in the dose range 1 ~ 3 tables in human body fits linear dynamic feature.

  4. 不同厂家米非司酮片的人体药动学比较%Pharmacokinetics of four preparations of mifepristone in healthy Chinese volunteers

    Institute of Scientific and Technical Information of China (English)

    董瑞谦; 滕艳妮; 俆延华; 郭瑞臣

    2012-01-01

    OBJECTIVE To study the pharmacokinetics of four different preparations of mifepristone tablets in healthy female Chinese subjects, METHODS Forty subjects were randomly divided into four groups with ten in each group, given respectively a single oral dose of 75 mg of four different preparations of mifepristone tablets. A series of blood were collected in 96 h. And mifepristone was extracted using ethyl acetate and determined by high performance liquid chromatography. Pharmacokinetics parameters were calculated by Drug and Statistical Software Version 2. 0. RESULTS The pharmacokinetics parameters after a single dose of 75 mg four preparations of mifepristone tablets were as follows :Cmax was (1. 57 ± 0. 36) μg ·mL-1 , (1.7 ±0.7) μg·mL·1, (1.4 ±0,4) μg·mL-1 and (1.6 ±0.5) μg·mL-1; t max was (0. 70 ± 0. 26) h, (1.0 ±0.6) h, (1.0 ± 0.6) hand (0.80 ±0.35) h; t1/2 was (26. 1 ±7.6) h, (26. 7 ±5. 2) h, (27. 1±6.4) h and (28. 9 ± 7. 4) h; AUC0-96 was (20. 3 ±5. 1) μg·mL-1 ·h, (20. 5 ±6. 4) μg·mL-1·h, (18. 1 ±8. 7) μg·mL-1·h and (20. 7 ±7. 4) μg·mL-1 ·h respectively. The relative bioavailability of mifepristone tablet B, C, D to mifepristone tablet A was 101. 1 % ,89. 4%and 101. 8%. CONCLUSION There was no significant difference among the pharmacokinetics of four different preparations of mifepristone tablets in healthy female Chinese subjects.%目的:进行A、B、C、D4厂家米非司酮片健康女性受试者体内的药动学比较研究.方法:40名健康女性受试者随机分为4组,每组10人,分别服用4个不同厂家生产的米非司酮片75 mg,于不同时间抽取肘静脉血,经液液萃取,采用高效液相色谱法测定米非司酮经时血浓度,DAS 2.0计算米非司酮药动学参数.结果:A、B、C、D4厂家米非司酮片的Cmax分别为(1.57±0.36)μg·mL-1、(1.7±0.7)μg·mL-1、(1.4±0.4)μg·mL-1和(1.6±0.5)μg·mL-1;tmax分别为(0.70±0.26)h、(1.0±0.6)h、(1.0±0.6)h和(0.80±0.35)h;t1/2

  5. 中国健康男性受试者单次口服盐酸伊伐布雷定前后心率与血药浓度的变化%Pharmacokinetics of single oral dose of ivabradine hydrochloride and effect on heart rate in healthy male volunteers

    Institute of Scientific and Technical Information of China (English)

    许莉; 蒋娟娟; 谢爽; 娄莹; 王莉; 庞会敏; 田蕾; 李一石

    2013-01-01

    Objective:To investigated the pharmacokinetics of single oral dose of ivabradine hydrochloride and evaluate its effect on heart rate in healthy male Chinese volunteers.Methods:Thirty-six volunteers were randomized to 3 groups:ivabradine 5 mg(n =12),10 mg(n =12),and 20 mg(n =12).Blood samples were collected at 0.25,0.5,0.75,1,1.5,2,4,6,8,12,and 24 h,and heart rates were recorded at 2,6,12,and 24 h after single dose administration of ivabradine.The plasma concentrations of invabradine were determined by HPLC-MS/ MS method.Results:After single dose administration,the Cmax was (9.67 ±4.55),(23.1 ± 13.0),and (46.9 ± 18.5) ng· mL-1 for 5,10,and 20 mg hydrochloride ivabradine respectively,Tmax was (1.0 ± 0.5),(1.0 ± 0.4),and (0.9 ± 0.5) h respectively.Resting heart rate was reduced at 2 h and returned to baseline at 6 h.The maximum decrease percentage of heart rate was (5.27 ± 10.96) %,(5.86 ± 12.50) %,and (10.17 ± 8.90) %,respectively.There was a significant lag time between peak plasma concentration of ivabradine and maximum bradycardic effect.The peak plasma concentration of ivabradine appeared at 45 min to 1 h after administration,while the maximum decrease of heart rate appeared at 2 h.Conclusion:This study shows that ivabradine could decrease the Chinese male healthy volunteer resting heart rate in a dose-dependent effect.%目的:评价中国健康受试者单次口服盐酸伊伐布雷定后血药浓度的变化及对心率的影响.方法:36例受试者随机分为3组,分别单次口服伊伐布雷定5,10,20 mg(每组n=12),在规定的时间内采集血样(药前,药后0.25,0.5,0.75,1,1.5,2,4,6,8,12,24 h)和测量心率(药前,药后2,6,12,24 h).采用HPLC-MS/MS法测定血浆中的盐酸伊伐布雷定浓度.结果:受试者单次口服盐酸伊伐布雷定5,10,20 mg后,达峰浓度Cmax分别为(9.67±4.55),(23.1±13.0),(46.9±18.5) ng·mL-1,达峰时间Tmax分别为(1.0±0.5),(1.0±0.4)和(0.9±0.5)h.单次服药后2h,

  6. The CFTR polymorphisms poly-T, TG-repeats and M470V in Chinese males with congenital bilateral absence of the vas deferens

    Institute of Scientific and Technical Information of China (English)

    Wu-Hua Ni; Lei Jiang; Qian-Jin Fei; Jian-Yuan Jin; Xu Yang; Xue-Feng Huang

    2012-01-01

    Congenital bilateral absence of the vas deferens (CBAVD) is a frequent cause of obstructive azoospermia,and mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene have also been frequently identified in patients with CBAVD.However,the distribution of the CFTR polymorphisms M470V,poly-T,TG-repeats and F508del mutation in the Chinese CBAVD population with presumed low cystic fibrosis (CF) frequency remains to be evaluated.Samples obtained from 109 Chinese infertile males with CBAVD and 104 normal controls were analyzed for the presence of CFTR (TG)m(T)n,M470V and F508del by PCR amplification followed by direct sequencing.Our study showed that the F508del mutation was not found in our patients.The 5T mutation was present with high frequency in Chinese CBAVD patients and IVS8-5T linked to either 12 or 13 TG repeats was highly prevalent among CBAVD patients (97.22% of 72 cases and 96.91% of 97 alleles with IVS8-5T).Moreover,a statistically significant relationship between TG12-5T-V470 haplotype and CBAVD was detected.This study indicated that the CFTR polymorphisms poly-T,TG-repeats and M470V might affect the process of CBAVD in the Chinese population.

  7. College Students' Volunteering: Factors Related to Current Volunteering, Volunteer Settings, and Motives for Volunteering

    Science.gov (United States)

    Moore, Erin W.; Warta, Samantha; Erichsen, Kristen

    2014-01-01

    Research has not explored the types of settings that college students prefer to volunteer for and how these settings might be influenced by personal factors (e.g., demographic, academic major, volunteering motivation, religiosity). Students from a Midwestern university (N = 406, 71.9% female) completed a survey that inquired about their…

  8. Committed Sport Event Volunteers

    Science.gov (United States)

    Han, Keunsu; Quarterman, Jerome; Strigas, Ethan; Ha, Jaehyun; Lee, Seungbum

    2013-01-01

    The purpose of this study was to investigate the relationships among selected demographic characteristics (income, education and age), motivation and commitment of volunteers at a sporting event. Three-hundred and five questionnaires were collected from volunteers in a marathon event and analyzed using structural equation modeling (SEM). Based on…

  9. Volunteering and Organizational Diversity

    DEFF Research Database (Denmark)

    Henriksen, Lars Skov; Rosdahl, David

    2008-01-01

    be explained by the same set of mechanisms and social theories. Hence, few analyses of determinants of volunteering try to break down the dependent variable into different types (Janoski and Wilson 1995; Grønbjerg and Never 2004). In many cases this is probably also due to a lack of sufficient data...... others work for ‘interest organizations' who try to influence policies and improve the conditions of their own membership. However, the common denominator is the effort to improve the welfare of others. Our third type called ‘societal volunteering' comprises the more ideological and political kind...... volunteering (Wilson and Musick 1997, 1998, 1999; Janoski and Wilson 1995). The model starts from the preposition that volunteer work is a productive activity. The fact that volunteer work is freely undertaken, uncommodified and unpaid does not make it unproductive (Wilson and Musick 1997:694). The idea...

  10. 盐酸伊伐布雷定对中国健康受试者的心率及QTc间期的影响%Impact of hydrochloride ivabradine on the heart rate and QTc interval of healthy Chinese volunteers

    Institute of Scientific and Technical Information of China (English)

    谢爽; 娄莹; 许莉; 景林德; 王冬雪; 闫丽荣; 李一石

    2013-01-01

    Objective To evaluate the impact of hydrochloride ivabradine on the heart rate and QTc interval after single and multiple doses in healthy Chinese volunteers.Methods Thirty-six volunteers were randomized into three groups:ivabadine 5 mg group (n =12,group 1)、10 mg group (n =12,group 2) and 20 mg group (n =12,group3).Each volunteer received single dose of ivabradine on day 1 and day 8,and was given ivabradine twice daily from day 3 to day 7.Results Resting heart rate was reduced from (62.67±5.68)bpm to (59.75±6.52) bpm in group1,(67.00±7.11) bpm to (62.75±8.35) bpm in group2,(59.75±6.52)bpm to (56.50±3.92)bpm in group3 at 2 hours after single dose administration and back to baseline after 6 hours.After 5 days continuous medication,the maximum heart rate (21.27±4.32) bpm,(26.74±5.21) bpm and (55.51±6.38)bpm in 3 groups respectively,the minimum heart rate was lowered (3.60±0.78) bpm,(3.25±0.52) bpm and (3.78 ± 0.43) bpm,the average heart rate was lowered (12.31 ± 1.43) bpm,(12.34± 1.29) bpm and (20.32±2.78)bpm,the total heart rate was reduced (9838.46±900.42)bpm,(11345.27+1213.54)bpm and (25461.46±2746.78)bpm.The QTc interval was decreased and demonstrated time-and dose-dependent.Phosphene-like mild transient visual symptoms were the most frequently reported adverse events.Conclusion Ivabradine at the doses of 5 mg to 20 mg bid was well tolerated and could decrease resting heart rate and QTc interval in healthy Chinese volunteers.%目的 评价单次及连续服用盐酸伊伐布雷定对中国健康受试者心率及QTc间期的影响.方法 36例受试者均分为3个剂量组,第1、8天单次口服相应剂量伊伐布雷定片5 mg(低剂量组)、10 mg(中剂量组)、20 mg(高剂量组);第3~7天连续5d,每次口服伊伐布雷定片相应剂量5、10、20 mg,每日2次.观察受试者心率、QTc间期的变化及不良事件的发生情况.结果 单次服药后2h,3组受试者心率均较服药前下降[(62.67±5.68)次/min对(59.75±6

  11. Investigation of pharmacokinetic data of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin revealed from single and multiple oral dose studies with a hypericum extract containing tablet in healthy male volunteers.

    Science.gov (United States)

    Schulz, Hans-Ulrich; Schürer, Michael; Bässler, Dagmar; Weiser, Dieter

    2005-01-01

    Hypericins, hyperforin and flavonoids are discussed as the main components contributing to the antidepressant action of St. John's wort (Hypericum perforatum). Therefore, the objective of the two open phase I clinical trials was to obtain pharmacokinetic data of these constituents from a hypericum extract containing tablet: hypericin, pseudohypericin, hyperforin, the flavonoid aglycone quercetin, and its methylated form isorhamnetin. Each trial included 18 healthy male volunteers who received the test preparation, containing 900 mg dry extract of St John's wort (STW 3-VI, Laif 900), either as a single oral dose or as a multiple once daily dose over a period of 14 days. Concentration/time curves were determined for the five constituents, for 48 h after single dosing and for 24 h on day 14 at the end of 2 weeks of continuous daily dosing. After single dose intake, the key pharmacokinetic parameters were determined as follows: Hypericin: Area under the curve (AUC(0-infinity)) = 78.33 h x ng/ml, maximum plasma concentration (Cmax) = 3.8 ng/ml, time to reach Cmax (tmax) = 7.9 h, and elimination half-life (t1/2) = 18.71 h; pseudohypericin: AUC(0-infinity) = 97.28 h x ng/ml, Cmax = 10.2 ng/ml, tmax = 2.7 h, t1/2 = 17.19 h; hyperforin: AUC(0-infinity) = 1550.4 h x ng/ml, Cmax = 122.0 ng/ml, tmax = 4.5 h, t1/2 = 17.47 h. Quercetin and isorhamnetin showed two peaks of maximum plasma concentration separated by about 3-3.5 h. Quercetin: AUC(0-infinity) = 417.38 h x ng/ml, Cmax (1) = 89.5 ng/ml, tmax (1) = 1.0 h, Cma (2) = 79.1 ng/ml, tmax (2) = 4.4 h, t1/2 = 2.6 h; isorhamnetin: AUC(0-infinity) = 155.72 h x ng/ml, Cmax (1) = 12.5 ng/ml, tmax (1) = 1.4 h, Cmax (2) = 14.6 ng/ml, tmax (2) = 4.5 h, t1/2 = 5.61 h. Under steady state conditions reached during multiple dose administration similar results were obtained. Further pharmacokinetic characteristics calculated from the obtained data were the mean residence time (MRT), the lag-time, the peak-trough fluctuation (PTF), the

  12. 中国男性皮肤及其化妆品市场特点%Characteristics of Chinese male skin and cosmetic market

    Institute of Scientific and Technical Information of China (English)

    毕永贤; 何聪芬

    2012-01-01

    This paper discussed the characteristics and differences between male and female skin of different parts in different ages. Based on the analysis of different types of male skin, feature targeted skin care for male was suggested. The physical, psychological and behavioral characteristics of Chinese male cosmetic consumers were investigated. According to the recent changes of the male cosmetic market in China, the author explored current problems and analyzed the reasons for their existence.%从不同皮肤部位及不同年龄阶段论述了男性与女性皮肤的差异及特点,通过分析不同类型的男性皮肤进而有针对性地进行护理。论述了中国男士化妆品消费者的生理、心理与行为特征,根据近年来中国男性化妆品市场发生的变化,分析其存在的问题及其原因。

  13. 盐酸度洛西汀肠溶胶囊在健康人体的药代动力学%Pharmacokinetics of duloxetine hydroehloride enteric capsules in Chinese healthy volunteers

    Institute of Scientific and Technical Information of China (English)

    张慧; 邱相君; 楼旦; 王增寿

    2012-01-01

    Objective To study the pharmacokinetics of duloxetine hydroehloride enteric capsules in healthy volunteers. Methods Ten healthy volunteers (five males and five females) received 60 mg duloxe-tine hydroehloride enteric capsules at a single oral dose. The concentra-tions of duloxetine in plasma were determined by HPLC. The pharmaco-kinetic parameters were calculated by DAS program. Results After a single dose of 60 mg duloxetine hydroehloride enteric capsules, the phar-macokinetic parameters for duloxetine were as follows; Cmax was (58. 74 ±7. 25) μg · L-1, Tmax was ( 6. 10 ± 0. 74) h, t1/2(ke) was (15. 79 ±1.17) h, AUC0-72 was (1423.01 ±157.29) μg · h · L-1. Conclusion Duloxetine was fitted to a one - compartment model with first absorption.%目的 研究盐酸度洛西汀胶囊(抗抑郁药)在健康人体内的药代动力学.方法 10名健康受试者,男女各半,单剂量口服盐酸度洛西汀肠溶胶囊60 mg.用高效液相色谱法测定血浆中度洛西汀的浓度;用DAS 2.0计算药代动力学参数.结果 度洛西汀的主要药代动力学参数:Cmax 为(58.74±7.25) μg·L-1,Tmax 为(6.10±0.74)h,t1/2(ke)为(15.79±1.17)h,AUCo-72为(1423.01±157.29)μg·h·L-1.结论 洛西汀在健康人体内符合一级吸收的一室模型.

  14. Human volunteer study with PGME: Eye irritation during vapour exposure

    NARCIS (Netherlands)

    Emmen, H.H.; Muijser, H.; Arts, J.H.E.; Prinsen, M.K.

    2003-01-01

    The objective of this study was to establish the possible occurrence of eye irritation and subjective symptoms in human volunteers exposed to propylene glycol monomethyl ether (PGME) vapour at concentrations of 0, 100 and 150 ppm. Testing was conducted in 12 healthy male volunteers using a repeated

  15. My volunteer work

    Institute of Scientific and Technical Information of China (English)

    卫子辰

    2015-01-01

    <正>As we all know,being a volunteer can help us learn many things,such as new skills,staying active,improving our social skills,accumulating work experience,making new friends with those who have the same topic,helping us grow more rapidly...I can still recall the days when I worked as a volunteer in a hospital in my city.The unforgetable experience was not only a volunteer work,but also a small society to me.It was in the summer vocation after high school entrance examination,when I had nothing to do but to play computer

  16. Volunteering, Happiness and Public Policy

    OpenAIRE

    2012-01-01

    Is the activity of volunteering something that benefits the volunteer as well as the recipient of the volunteer's activities? We analyze this relationship and apply matching estimators to the large- scale British Household Panel Survey (BHPS) data set to estimate the causal impact of volunteering on happiness. We take into account personality traits that could jointly determine volunteering behaviour and happiness. We find that the causal impact of volunteering on happiness is positive and in...

  17. The relationships among perceived organizational support, intention to remain, career success and self-esteem in Chinese male nurses

    OpenAIRE

    2015-01-01

    Aim: The purpose of this study was to investigate the relationships among perceived organizational support, intention to remain, career success and self-esteem in male nurses in China. Background: Recently, turnover is considered increasingly more normal. Male nurses could be stabilized by improving their perceived organizational support, career success and self-esteem. Design: A cross-sectional design was used in the present study. Method: 405 full-time male Registered Nurses, from ...

  18. NASTEP Volunteer Request (CSA) -

    Data.gov (United States)

    Department of Transportation — Allows users to add themselves to a Service Area wide ?volunteer for emergency duty? list (was created after Gulf Coast Hurricanes). Approval and email by managers,...

  19. The Effective Volunteer Teacher

    OpenAIRE

    2013-01-01

    This publication provides information for volunteer teachers of adults and older youth on how to conduct an effective presentation. Topics include focus of presentation, characteristics of the learners, teaching methods, visual aides and evaluations.

  20. 苯扎贝特在中国汉族和藏族健康人体内的药动学初探%Pharmacokinetics of bezafibrate in Chinese Han and Tibetan healthy volunteers

    Institute of Scientific and Technical Information of China (English)

    李忠亮; 张治然; 袭荣刚

    2012-01-01

    Objective To determine the pharmacokinetics of bezafibrate tablets after a single oral dose in Han and Tibetan healthy volunteers. Methods Ten healthy Han volunteers and 10 healthy Tibetan volunteers enrolled in the study. Each subject received a single dose of 400 mg bezafibrate tablets. The plasma concentration was determined by HPLC. The pharmacokinetic parameters were calculated by DAS and statistically analyzed by SPSS. Results The main pharmacokinetic parameters of Chinese Han were as follows: Cmax (11.33±3.02) μg · mL-1, tmax (1.96±0. 21) h, t1/2 (2.05±0.37) h, AUC0-12 (40. 54± 11. 25) μg · H · mL-1, and AUC0-∞ (46. 63 ±12. 42) μg · H · mL-1. The main pharmacokinetic parameters of Tibetan were as follows- C (11.17±3. 26) μg · mL-1, tmax(2. 05±0. 32) h, t1/2 (2.04±0.31) h, AUC0-12 (38.25±9.74) μg · H · mL-1, and AUC0-∞ (44. 52± 10. 35) vg · H · mL-1. Conclusion The plasma concentration-time curve of bezafibrate fits a two-compartment open model. Due to the small number of volunteers in the trial, further research is needed.%目的 研究汉族和藏族健康志愿者单剂量口服苯扎贝特片的药物动力学.方法 健康志愿者20名(其中汉族和藏族各10名,男女各半),单剂量口服笨扎贝特片400 mg,采用HPLC法测定血浆中苯扎贝特的含量.用DAS软件程序进行数据处理,用SPSS软件对不同性别药动学参数进行统计分析.结果 受试者单剂量口服400 mg苯扎贝特片后,汉族健康志愿者的主要药动学参数:Gmax为(11.33±3.02)μg·mL-1,tamx为(1.96±0.21)h,t1/2为(2.05±0.37)h,AUC0-12为(40.54±11.25)μg·h·mL-1;AUC0~∞为(46.63±12.42)μg·h·mL-1.藏族健康志愿者的主要药动学参数:Cmax为(11.17±3.26)μg·mL-1,tmax为(2.05±0.32)h,t1/2为(2.04±0.31)h,AUC0~12为(38.25±9.74)μg·h·mL-1; AUC0-∞为(44.52±10.35)μg·b·mL-1.结论 健康志愿者单剂量口服苯扎贝特片的体内药动学过程符合二室开放模型.由于样本数太少,

  1. Institutional Facilitation in Sustained Volunteering among Older Adult Volunteers

    Science.gov (United States)

    Tang, Fengyan; Morrow-Howell, Nancy; Hong, Songiee

    2009-01-01

    As more nonprofit organizations rely on older adult volunteers to provide services, it is important to retain volunteers for an extended period of time to ensure service quality and the beneficial outcomes of volunteering. Nonprofit organizations are positioned to facilitate older adult volunteers' role performance. Based on an institutional…

  2. Wasted Resources: Volunteers and Disasters

    Science.gov (United States)

    2009-12-01

    included using proven human resource management techniques, to include screening and providing handbooks of what to expect before volunteers are...the relief & recovery stages.  Operates volunteer centers to serve as clearing houses for relief teams. American Radio Relay League ( ARRL ...cellular and other infrastructure-dependent systems.  ARRL volunteers act as communications volunteers with local public safety organizations. In

  3. A yang-invigorating Chinese herbal formula enhances mitochondrial functional ability and antioxidant capacity in various tissues of male and female rats.

    Science.gov (United States)

    Leung, Hoi Yan; Chiu, Po Yee; Poon, Michel K T; Ko, Kam Ming

    2005-01-01

    The practice of traditional Chinese medicine (TCM) always emphasizes the prevention of diseases and delaying the onset of senility. In this regard, the maintenance of a balance of Yin and Yang-two opposing components involved in life activities as exemplified by the antagonistic action of the sympathetic and parasympathetic nervous systems-is essential in achieving a healthy condition. Previous studies have shown that long-term treatment with a Yang-invigorating Chinese herbal formula (VI-28) could increase red cell CuZn-superoxide dismutase (SOD) activity in male human subjects. In the present study, we examined the effects of chronic VI-28 treatment (80 and 240 mg/kg/day for 30 days) on red cell CuZn-SOD activity as well as mitochondrial functional ability and antioxidant components in various tissues of male and female rats. The results indicated that VI-28 treatment increased red cell CuZn-SOD activity as well as mitochondrial ATP generation capacity, reduced glutathione and alpha-tocopherol levels, and Mn-SOD activity in brain, heart, liver, and skeletal muscle tissues in both male and female rats to varying extents. The VI-28?induced increase in mitochondrial antioxidant capacity in various tissues was evidenced by the significant reduction in the extent of reactive oxygen species generation assessed by in vitro measurement. The red cell CuZn-SOD activities correlated positively with tissue mitochondrial antioxidant component levels/activity. The beneficial effect of VI-28 treatment on mitochondrial functional ability and antioxidant capacity may have clinical implications in the prevention of age-related diseases.

  4. Study on Pharmacokinetics of Cetirizine/Pseudoephedrine Extended - Release Tablet in Chinese Volunteers%西替伪麻缓释片在中国志愿者体内的药代动力学研究

    Institute of Scientific and Technical Information of China (English)

    胡岳江; 张志涛; 蒋志文

    2011-01-01

    Objective To study the pharmacokinetics of Cetirizine/Pseudoephedrine Extended - Release Tabiet in Chinese volunteers. Methods Tweenty - four healthy volunteers were divided into 2 groups to receive orally a single dose of Cetirizine/Pseudoephedrine Extended - Release Tablet 1 or 2 pills respectively. Then 12 volunteers of the total each received 2 tablets per day for 5 consecutive days. The concentrations of cetirizine and pseudoephedrine in human plasma were determined simultaneously by LC - MS/MS method. Results The main pharmacokinetic parameters of cetirizine of 2 groups after single -dose were as follows: Cmax were (134. 5 ±22. 0)μg/L and (290. 9±47.4) μg/L; AUC0 -36 h were (1 369. 3±314. 9) μg · h/L and (2 403. 0±304. 9) μg · h/L, respectively. The main pharmacokinetic parameters of pseudoephedrine were as follows: Cmax were (434. 2 ±95. 0) μg/L and (932. 5 ±280. 8) μg/L; AUC0-36 h were (6 160. 7 ±1 477. 4) and (12 871.4± 4 863. 2)μg · h/L, respectively. The main pharmacokinetic parameters of cetirizine and pseudoephedrine after multi - doses were as follows: Cav were (135. 6 ±23. 4) μg/L and (417. 9 ± 126. 0) μg/L; Tmax were (0. 9 ±0. 5)h and (4. 1 ± 1. 7) h; AUss were (1 626. 7±280. 8) μg ·h/L and (5 015. 0 ± 1511. 8) μg · h/L; DF were 1. 3 ±0. 2 and 0. 7±0. 2, R were 1. 3 ± 0. 1 and 1. 2±0. 1 ,respectively. Conclusion The method was proved to be rapid, sensitive, accurate and convenient. There were no accumulations in vivo after multiple oral doses. Pseudoephedrine had extended - release character from the test tablet.%目的 研究中国健康志愿者口服西替伪麻缓释片的药动学过程.方法 将24名志愿者随机均分为高剂量组和中剂量组,分别单次口服西替伪麻缓释片1片和2片;单次给药结束1周后,中剂量组12名受试者连续5 d每天口服2片,采用液相色谱-串联质谱法同时测定人血浆中西替利嗪和伪麻黄碱的质量浓度.结果 西替利嗪单次给药

  5. 盐酸美金刚片在中国健康人体的生物等效性%Study on the bioequivalence of memantine hydrochloride tablets in Chinese healthy volunteers

    Institute of Scientific and Technical Information of China (English)

    郑恒; 周华; 任丽; 钱振宇; 彭彦

    2012-01-01

    目的:评价国产与进口盐酸美金刚片在中国健康人体的生物等效性.方法:20名健康男性受试者随机交叉单剂量口服受试制剂或参比制剂盐酸美全刚片各10 mg.用高效液相色谱-串联质谱法测定血浆中美金刚浓度;用DAS3.0软件计算药动学参数,并对两种药物进行生物等效性评价.结果:受试制剂和参比制剂的主要药动学参数:Cmax分别为(18.1±3.8)和(20.3±4.2)ng·mL-1;tmax分别为(12.7±15.1)和(8.8±3.0)h;t1/2分别为(60.8±15.5)和(61.4±19.2)h;AUC0-t分别为(1748.6±338.9)和(1720.2±317.3)ng·h·mL-1.AUC0-t、AUC0-∞、Cmax的90%置信区间分别为89.8%~105.6%、89.7%~106.1%、84.8%~93.9%.受试制剂相对生物利用度F0-t为(95.5±2.9)%.结论:受试制剂与参比制剂具有生物等效性.%OBJECTIVE To evaluate the bioequivalence of two preparations of memantine hydrochloride in healthy volunteers. METHODS A single oral dose of 10 mg test preparation or reference preparation memantine hydrochloride tablets were given to 20 male healthy volunteers in a randomized crossover study. The concentrations of memantine were determined by HPLC-MS/MS method. The pharmacokinetic parameters and relative bioavailability were calculated by DAS 3. 0 software, and then the bioequivalence was judged. RESULTS The main pharmacokinetic parameters of test preparation and reference preparation were as follows: Cmax was (18. 1 ±3.8), (20. 3 ±4. 2) ng·mL-1; t max was (12. 7 ± 15. 1), (8.8 ± 3.0) h; t1:2 was (60.8 + 15.5), (61. 4 ± 19.2) h; AUC0-t was (1 748. 6 ± 338. 9). (1 720. 2 ± 317. 3) ng·h· mL-1 , respectively. The 90% CIs for the ratios of AUG0-T、AUG0-∞ ,C max were 89. 8% ~1()5. 6%,89. 7%~106. 1%,84. 8%~93. 9%, respectively. The relative bioavailability of test preparation was (95.5 ±2. 9)%. CONCLUSION The results demonstrated that the two preparations were bioequivalent.

  6. Be a Volunteer

    Institute of Scientific and Technical Information of China (English)

    吴世纪

    2016-01-01

    I’m writing to recommend myself as a volunteer for"Help You Know More about Lianyungang".I’m a student in Class 1,Grade 7.I like English and I’m good at it.I am also good at sports.I am good with my classmates and teachers.I have plenty of free time after school.I also know Lianyungang well.I’d like to be a volunteer because it’s a good chance for me to help others.I can help the tourists

  7. The presence of human papillomavirus and Epstein-Barr virus in male Chinese lichen sclerosus patients: a single center study

    Directory of Open Access Journals (Sweden)

    Yumeng Zhang

    2016-01-01

    Full Text Available This study aimed to investigate the presence of human papillomavirus and Epstein-Barr virus in male lichen sclerosus patients. We extracted DNA from formalin-fixed paraffin-embedded foreskin tissue blocks of 47 male LS patients and 30 healthy men and performed real-time PCR test to detect HPV and EBV. None of the 47 LS patients and 30 healthy men had detectable HPV infection. EBV was detected in 18 LS patients (38.3% and four healthy men (13.3%, the difference is significant (P < 0.05. Tissue blocks with significant inflammatory reaction tend to have higher EBV load. HPV has no significant relationship with LS. Male LS patients have higher EBV infection rate, but the role of EBV in the pathogenesis of LS needs further investigate.

  8. Are the Aging Male's Symptoms (AMS) scale and the Androgen Deficiency in the Aging Male (ADAM) questionnaire suitable for the screening of late-onset hypogonadism in aging Chinese men?

    Science.gov (United States)

    Chen, Wei; Liu, Zhi-Yong; Wang, Lin-Hui; Zeng, Qin-Song; Wang, Hui-Qing; Sun, Ying-hao

    2013-09-01

    The Aging Male's Symptoms (AMS) scale and the Androgen Deficiency in the Aging Male (ADAM) questionnaire have been widely used for screening men suspected of late-onset hypogonadism (LOH). We evaluated the consistency of the two questionnaires with sex hormone levels. A total of 985 men completed the two questionnaires, as well as an analysis of the serum levels of total testosterone (TT), bioavailable testosterone (BT), luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2), prolactin (PRL) and sex hormone-binding globulin (SHBG). No correlation was observed between any hormone level and the psychological or somatic section of the AMS score, whereas the sexual section was correlated with the levels of FT, LH, FSH, SHBG and BT. Significant correlations were observed between the result of the two questionnaires and these hormone levels. When LOH was defined as TT AMS scale were 54.0% and 41.2% compared with 78.7% and 14.8% for the ADAM questionnaire. Several sex hormone levels correlated with the two questionnaires, but neither of these questionnaires had sufficient sensitivity and specificity. It is necessary to provide a new questionnaire applicable to the Chinese population to screening LOH.

  9. Retired RNs: perceptions of volunteering.

    Science.gov (United States)

    Cocca-Bates, Katherine C; Neal-Boylan, Leslie

    2011-01-01

    A qualitative study was done to explore the perceptions of volunteering among retired registered nurses (RNs) in Kansas. Participants were volunteers in formal nursing roles or were using their nursing knowledge and experience in non-nursing roles, such as church work. Regardless of the type of volunteer position, retired RNs reported that they use what they have learned as nurses when they volunteer. Volunteering benefits include enhanced self-worth, intellectual stimulation, reduced social isolation, and opportunities to help others. Increased paperwork, new technology, difficulty finding nursing-specific volunteer opportunities, resistance from health care organizations, and a lack of respect for what these nurses know are challenges and barriers to volunteering. Retired RNs have accumulated years of clinical nursing experience and can be helpful to employed nurses. Health care organizations should launch targeted efforts to recruit and utilize retired RN volunteers. Health care professionals who care for older adults should recommend volunteering as a healthful endeavor.

  10. Call for volunteers

    CERN Multimedia

    2008-01-01

    CERN is calling for volunteers from all members of the Laboratory for organizing the two exceptional Open days.CERN is calling for volunteers from all members of the Laboratory’s personnel to help with the organisation of these two exceptional Open Days, for the visits of CERN personnel and their families on the Saturday and above all for the major public Open Day on the Sunday. As for the 50th anniversary in 2004, the success of the Open Days will depend on a large number of volunteers. All those working for CERN as well as retired members of the personnel can contribute to making this event a success. Many guides will be needed at the LHC points, for the activities at the surface and to man the reception and information points. The aim of these major Open Days is to give the local populations the opportunity to discover the fruits of almost 20 years of work carried out at CERN. We are hoping for some 2000 volunteers for the two Open Days, on the Saturday from 9 a.m. to ...

  11. Making room for volunteers

    DEFF Research Database (Denmark)

    Nielsen, Rasmus Kleis

    2012-01-01

    that is singleminded in its instrumental pursuit of victory can thus be less effective than one that is more accommodating- a campaign that makes room for volunteers by accepting that, unlike staffers, they come to politics with a different perspective and conception of what is and ought to be going on....

  12. Volunteers who care

    NARCIS (Netherlands)

    Jeroen Devilee

    2008-01-01

    Original title: Vrijwillig verzorgd. Everyone knows them: volunteers from churches and other civil-society organisations who visit the chronically sick, lonely elderly and other people in need. This service is provided from a wide array of organisations. Unfortunately, it is by no means always clea

  13. Novel FGFR1 and KISS1R Mutations in Chinese Kallmann Syndrome Males with Cleft Lip/Palate

    Directory of Open Access Journals (Sweden)

    Hao Xu

    2015-01-01

    Full Text Available Kallmann syndrome (KS is characterized by isolated hypogonadotropic hypogonadism (IHH with anosmia and is sometimes associated with cleft lip/palate (CLP. In order to describe the clinical features, genetic etiology, and treatment outcome of KS males with CLP, we performed genetic screening for 15 known causal IHH genes (KAL1, FGFR1, NELF, FGF8, CHD7, WDR11, SEMA3A, KISS1R, KISS1, PROKR2, PROK2, TAC3, TACR3, GNRH1, and GNRHR in four KS with CLP patients and six IHH patients without CLP. Two novel heterozygous missense mutations in FGFR1, (NM_001174066: c.776G>A (p.G259E and (NM_001174066: c.358C>T (p.R120C, were identified in a 23-year-old KS male with cleft lip and an 18-year-old KS patient with cleft lip and palate, dental agenesis, and high arched palate, respectively. These two mutations were not presented in their healthy parents and 200 normal controls. One novel heterozygous missense mutation in KISS1R, (NM_032551: c.587C>A (p.P196H, was identified in an 18-year-old KS male with cleft lip and dental agenesis who developed sperm after being treated with gonadotropin. This mutation was also presented in his healthy father and grandfather. These results have implications for the diagnosis, genetic counseling, and treatment of KS and CLP males with mutations in FGFR1 gene.

  14. Measurement of Some Physiological and Biochemical Indexes of the Antisense Fragment of CYP86MF Gene Transgenic Male Sterile Plantlets in Chinese Cabbage-Pak-Choi

    Institute of Scientific and Technical Information of China (English)

    YU Xiao-lin; CAO Jia-shu; DONG De-kun

    2003-01-01

    In order to study the mechanism of the transgenic male sterility induced by the antisense fragment of gene CYP86MF, some physiological and biochemical indexes were compared between the transgenic plantlets of Chinese cabbage-pak-choi (Brassica campestris L. ssp. chinensis Makino) and their controls.Results showed that there was significant difference between content of the endogenous hormones in leaves and floral buds. GA3 contents in leaves of the transgenic plantlets of B. campestris L. ssp. chinensis Makino cv.Shanghai-qing and cv. Youqing were reduced by 31.72 and 46.88% respectively as compared with those of their controls, and GA3 contents in floral buds of them were reduced by 62.92 and 80.57 % respectively. In addition, ZT contents in leaves of cv. Shanghai-qing and cv. Youqing were reduced by 11.81 and 181.20%respectively as compared with those of their controls and those in floral buds were reduced by 105.94 and 128.75% respectively. But, ABA content in transgenic plantlets was significantly higher than that in nontransgenic plantlets. However, differences among respiratory rate and cyanide-resistant respiratory rate, the photosynthesic rate and the content of total flavones in floral buds were not significant. In this study, the results indicated that the gene CYP86MF might be one of the key functional genes to control fertility of Chinese cabbage.

  15. Breeding of Nuclear Male Sterile Line in Qingmaye Type of Chinese cabbage%青麻叶结球白菜雄性不育系的转育

    Institute of Scientific and Technical Information of China (English)

    闻凤英; 宋连玖; 王玉龙; 刘晓晖; 赵冰; 丘玉秀

    2001-01-01

    The male sterile line 3A was being used as a source o f male sterility,the fertile line Qingmaye Hei227 as goal parent,the gene of m ale sterility was transferred to the Qingmaye type of Chinese cabbage by crossi ng,self,sibling and test crossing.The male sterile line of Qingmaye type S10 w as obtained,its sterility percent and degree were all 100%,its nectary and see d were all normal.Its horticultural characters were same as Qingmaye type.The co mbining ability of S10 and its combinations was tested.The transferring me thod of genetic male sterile line was discussed.%利用核型雄性不育系3A作为不育源,以青麻叶材料黑227为目标亲本,经过杂交、自交、兄妹交、测交等转育手段,将雄性不育基因转育到青麻叶结球白菜上,获得了青麻叶类型雄性不育系S10,其不育株率和不育度均为100%,蜜腺正常,结籽正常,农艺性状与青麻叶类型结球白菜基本相同。对育成的雄性不育系S10进行了配合力测定,并对所配组合做了品比试验。

  16. Investigation into the association between P2RX7 gene polymorphisms and susceptibility to primary gout and hyperuricemia in a Chinese Han male population.

    Science.gov (United States)

    Ying, Ying; Chen, Yong; Li, Zhen; Huang, Haiyan; Gong, Qiongyao

    2017-02-27

    The purpose of this study was to investigate the relationship between P2RX7 gene single nucleotide polymorphisms and primary gout and hyperuricemia in a Chinese Han male population. The genetic distributions of the single nucleotide polymorphisms (SNPs) rs2230911, rs208294, rs435309, rs28360447, rs1718119, rs28360457, and rs3751143 in P2RX7 were detected in 293 primary gout patients, 187 hyperuricemia patients and 269 controls using SNaPshot technology. Statistical analyses were implemented using SPSS version 20.0. The genetic distributions of each group were tested for Hardy-Weinberg equilibrium (HWE). T test, analysis of variance, rank sum test and Chi-square test were measured to assess differences in clinical data and polymorphisms among groups. Logistic regression was used to assess susceptibility to disease with odds ratios (ORs) and 95% confidence intervals (95% CIs). SHEsis software was used to calculate linkage disequilibrium blocks and haplotype association risk. P  .05). In the comparison between primary gout and control, the frequencies of rs2230911 genotypes were significantly different (P = .002), and allele G was associated with a higher risk of primary gout than allele C [OR (95% CI) = 1.755 (1.278, 2.410), P  .0167). Similarly, there were no obvious differences in the other two polymorphisms among the three groups (P > .05). Our results reveal that P2RX7 rs2230911 may be associated with primary gout risk in a Chinese Han male population and allele G may be a susceptibility factor for primary gout.

  17. Association of an Exon SNP of SLC2A9 Gene with Hyperuricemia Complicated with Type 2 Diabetes Mellitus in the Chinese Male Han Population.

    Science.gov (United States)

    Xing, Shi-Chao; Wang, Xu-Fu; Miao, Zhi-Min; Zhang, Xue-Zhi; Zheng, Jun; Yuan, Ying

    2015-04-01

    Several recent genome-wide association studies and following studies have identified that genetic variants of SLC2A9 are associated with hyperuricemia (HUA) and diabetes mellitus (DM). Here, we set to investigate whether the exon 9 of SLC2A9 gene variations is associated with HUA complicated with Type 2 DM (T2DM) in the Chinese male Han population. The present study was designed to study rs2280205 polymorphism in exon 9 of SLC2A9 in 232 Chinese male subjects. Rs2280205 locus was genotyped in 52 T2DM subjects, 65 HUA subjects, 55 subjects with HUA complicated with T2DM, as well as 60 control subjects in this study. DNA from peripheral blood was purified and amplified by polymerase chain reaction (PCR). The PCR products were then digested by restriction enzyme MSPI, and part of PCR products was sequenced and analyzed. There was no significant difference in the levels of cholesterol, creatinine, and urea nitrogen between the Control Group and the HUA group. There was also no significant difference in levels of cholesterol between the DM group and Control Group. No significant difference in cholesterol and uric acid was observed between the HUA group and the HUA accompanied with DM group (P > 0.05). However, there was no statistical significance in the genotype frequency in these groups (P > 0.01). Results of the present study suggest that the exon 9 of SLC2A9 gene 109C/T polymorphism is not associated with HUA and diabetes in population living in the coastal area of Shandong province, China.

  18. Pharmacokinetic interaction between cefaclor and bromhexine in healthy Chinese volunteers%头孢克洛与溴己新在中国健康人体内药动学环节的相互作用

    Institute of Scientific and Technical Information of China (English)

    龚倩; 胡哲益; 黄志壮; 王黎青; 刘文芳; 郭歆; 曹伟; 王霆; 程泽能

    2007-01-01

    目的:研究头孢克洛和溴己新在中国健康成人体内药动学环节的相互作用.方法:采用3×3拉丁方试验设计,12名健康受试者在不同周期内分别多剂量口服头孢克洛片、盐酸溴己新片或头孢克洛片加盐酸溴己新片,周期间洗脱时间(Wash-out)为14 d.血及尿样中头孢克洛浓度采用HPLC-UV法测定,溴己新浓度采用HPLC-MS法测定.结果:将合并给予头孢克洛及溴己新组与单独给予头孢克洛组的主要药动学参数进行比较.头孢克洛的Cmax,AUC0-6(梯形面积)经对数转化后进行方差分析,结果表明二者均无统计学差异,双单侧t检验表明,两参数均落在各自相应的90%可信区间内,合用与单独使用相比,头孢克洛生物等效.tmax经Mann-Whitney检验,结果表明两组间无统计学差异.其他药动学参数(如:Vd/F,t1/2,Clr及MRT等)进行方差分析,结果显示:Vd/F有统计学差异,其他参数无统计学差异.将合并给予头孢克洛和溴己新组与单独给予溴己新组的主要药动学参数进行比较.溴己新的主要药动学参数Cmax,AUC0-24(梯形面积)经对数转化后进行方差分析,结果表明二者无统计学差异,双单侧t检验表明,两参数均落在各自相应的90%可信区间内,合用与单独使用相比,溴己新生物等效.tmax经Mann-Whitney检验,结果表明无统计学差异.其他药动学参数(如:Vd/F,t1/2,Clr及MRT)进行方差分析,参数均无统计学差异.结论:联合服用盐酸溴己新片与头孢克洛,药物的吸收、代谢及排泄不受影响;头孢克洛的表观分布容积高于单用头孢克洛,这可能是两药药效学协同作用的药动学基础.%Objective To determine the pharmacokinetic interaction between cefalor and bromhexine in healthy Chinese volunteers. Methods Twelve subjects received a cefaclor (CEF) treatment, a bromhexine (BHX) treatment, and a co-treatment of CEF and BHX with a 3 × 3 Latin square design. The wash-out time between

  19. Pharmacokinetics of Prulifloxacin Tablets in Chinese Healthy Volunteers%健康人单次和多次口服普卢利沙星片的药动学研究

    Institute of Scientific and Technical Information of China (English)

    陈坤明; 全淑花; 江海燕; 贺毅; 邱相君; 胡国新

    2009-01-01

    OBJECTIVE To investigate the pharmacokinetics of prulifloxacin tablets in Chinese healthy volunteers after a single dose and multiple doses. METHODS Using crossover design, a single dose of 200, 400, 600 mg of prulifloxacin tablets and multiple doses of 400 mg were given to each of 10 healthy volunteers. The concentrations of NM394, an active metabolite of prulifloxacin in plasma, were determined by HPLC. The pharmacokinetic parameters were calculated by DAS2.0 programme. RESULTS The elimination half life and the mean residence time of single dose were obtained and the means of ρ_(max), AUC_(0-t), and AUC_(0-∞) had a good linear relationship with the dose. The obtained pharmacokinetic parameters of prulifloxacin tablets in multiple doses of 400 mg group were as follows: AUC_(0-36)~(ss) (15.69±3.20) mg·h·L~(-1), AUC_(0-∞)~(ss) (16.38±3.34) mg·h·L~(-1), t_(1/2a)(1.28±0.58) h, t_(1/2β) (7.95±3.28) h. CONCLUSION The differences of the main pharmacokinetic parameters of t_(1/2), V/F and CL/F between each group were not significant and drug accumulation was not found. There was no drug accumulation and prulifloxacin showed good safety.%目的 研究健康受试者单次和多次口服普卢利沙星片后的药动学过程.方法 采用多周期试验设计,10名健康受试者单次po(200,400,600mg)和多次po(400mg)普卢利沙星片;采用HPLC测定普卢利沙星活性代谢物噻丁啶-喹啉羧酸衍生物(NM394)的血药浓度.用DAS2.0程序计算主要药动学参数,并进行统计分析.结果 健康志愿者单次及多次口服普卢利沙星片后,其活性代谢物NM394符合一级吸收一级消除的二室模型.主要药动学参数:单次给药低、中、高3种剂量普卢利沙星血浆活性代谢物NM394的消除半衰期及体内平均驻留时间相近,ρ_(max)、AUC_(0-t)和AUC_(0-∞)均值与剂量呈良好的线性;多次给药ρ_(av)~(ss)为(1.02±0.18)mg·L~(-1),DF为(2.174±0.48),AUC_(0-36)~(ss)为(15.69±3.20)mg·h·L~(-1

  20. 屈螺酮炔雌醇片在中国健康女性的生物等效性研究%Bioequivalence study of drospirenone and ethinylestradiol tablets in Chinese healthy volunteers

    Institute of Scientific and Technical Information of China (English)

    杨周生; 郭歆; 刘智; 封敏素; 苏桃; 陈爱巧; 程航; 郭韧

    2015-01-01

    Objective To evaluate the bioavailability of drospirenone and ethinylestradiol tablets, and to assess its bioequivalence in Chinese healthy volunteers.Methods A two drugs, two periods, crossover trial was designed, a single oral dose of subject drug and 6 mg drospirenone-0.06 mg ethinyloestradiol was given to thirty-four healthy female volun-teers, respectively.The concentrations of drospirenone and ethinylestra-diol in plasma were determined by HPLC-MS/MS.The pharmacokine-tic parameters of drospirenone and ethinylestradiol were calculated and analyzed by WinNonlin 6.1 software.Results The main pharmacokinet-ics parameters of drospirenone in subject drug and reference drug were as follow:Cmax were (69.6 ±16.6), (71.6 ±15.9)μg・ L-1, tmax were (1.6 ±0.7 ) , ( 1.5 ±0.7 ) h, AUClast were ( 845.2 ±229.1 ) , (831.3 ±217.8)μg・ L-1 ・ h, AUCinf were ( 968.6 ±233.3 ), (965.5 ±243.1)μg・ L-1・ h;t1/2 were (30.8 ±5.9) and(31.8 ±7.2) h, the relative bioavailability of subject drug were as follow: Flast was (102.4 ±14.0)%, Finf was (101.6 ±13.2)%.The main pharmacokinetics parameters of ethinyloestradiol in subject drug and reference drug were as follow: : Cmax were (139.6 ±49.7), (131.0 ± 45.1) ng・ L-1, tmax were (1.6 ±0.4), (1.7 ±0.5) h, AUClast were (1256.3 ±408.3), (1205.6 ±440.7) ng・ L-1・ h, AUCinf were (1420.9 ±429.8), (1403.3 ±495.3)ng・ L-1・ h; t1/2 were (12.4 ±3.1), (13.5 ±5.6)h, the relative bioavail-ability of subject drug were as follow:Flast was (110.3 ±34.0)%, Finf was (107.2 ±31.7)%.Conclusion Subject drug and reference drug have bioequivalence.%目的:研究屈螺酮炔雌醇片的生物利用度,评价其生物等效性。方法用两药物、两周期、交叉试验设计。34名健康女性受试者随机分为2组,单剂量口服试验药物或参比药物2片。用HPLC-MS/MS法分别测定血浆中屈螺酮及炔雌醇的浓度,用Phoenix WinNonlin 6.1软件计算屈螺酮及炔雌醇的药代动力

  1. 液相色谱-质谱联用法测定人血浆中多潘立酮及其在健康中国志愿者中的药物动力学%Determination of domperidone in human plasma by LC-MS and itspharmacokinetics in healthy Chinese volunteers

    Institute of Scientific and Technical Information of China (English)

    吴民淑; 高凌; 蔡晓辉; 王广基

    2002-01-01

    AIM: To determine the concentration of domperidone inhuman plasma and investigate its pharmacokinetics inChinese male volunteers following oral administration of asingle dose of the medicine 20 mg. METHODS:Plasma samples were processed by liquid-liquid extractionand a liquid chromatographic-mass spectrometric assaywas developed for the determination of domperidone inhuman plasma. RESULTS: Assay linearity wasobtained in the range of 0.52 - 154.5 μg/L ( r =0.9999). The recovery of domperidone from humanplasma was more than 75 %. The intraday and interdayrelative standard deviations (RSD) for the lowestconcentration examined (0.52 μg/L) were 9.4 % and7.6 %, respectively. The method was utilized to deter-mine the concentration of domperidone in Chinese malevolunteers. The concentration-time curve was fitted to atwo-compartnent model. Its main pharmacokineticparameters were: Tmax = (0.8 ± 0.7) h, Cmax=(50±32) μg/L, T1/2 = ( 7.8 ± 1.6) h. CONCLUSION:The method described in this report was of high sensitivityand selectivity for accurate determination of the plasmaconcentration of domperidone in human.1 Correspondence to Prof WANG Guang-Ji, PhD.Phn 86-25-327-1544. Fax 86-25-330-2827.E-mail gjwang@ mailbox. cpu. edu. cn%目的:测定人血浆中多潘立酮的浓度,并研究在中国志愿者中单剂量口服20 mg后的药物动力学过程.方法:用液-液萃取法提取血浆中药物.采用液相色谱-质谱联用分析手段,建立测定人血浆中多潘立酮浓度的分析方法.结果:多潘立酮在0.52-154.5μ/L浓度范围内线性良好(r=0.9999),其在人血浆中的回收率大于75%,低浓度(0.52 μg/L)的日内、日间差异分别为9.4%和7.6%.多潘立酮的血药浓度-经时曲线符合二房室模型,其主要药物动力学参数为:Tmax=(0.8±0.7)h,Cmax=(50±32)μ/L T1/2=(7.8±1.6)h.结论:本方法专属性强,灵敏度高,可准确测定多潘立酮在人血浆中的浓度.

  2. Clinical utility of the UPOINT phenotype system in Chinese males with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS: a prospective study.

    Directory of Open Access Journals (Sweden)

    Zhigang Zhao

    Full Text Available BACKGROUND: Recent data showed that a six-domain UPOINT is a flexible and responsive new classification system that has the clinical applicability in CP/CPPS. However, the utility of UPOINT algorithm in men in China with CP/CPPS has not been comprehensively studied. For international validation and adoption, we evaluated this clinical phenotype system for a large cohort of Chinese CP/CPPS patients and correlated it with patient symptoms and erectile dysfunction (ED. We also investigated the addition of an ED domain in regard to symptom correlation. METHODS: A total of 389 Chinese males with CP/CPPS were prospectively collected and classified in each domain of the UPOINT system. Symptom severity was measured using the NIH-CPSI and IPSS. The erectile function was evaluated using the IIEF-5. Clinically relevant associations were calculated. RESULTS: The percentage of patients positive for each domain was 54.0%, 42.1%, 41.9%, 20.8%, 26.7%, and 40.4% for the Urinary, Psychosocial, Organ-specific, Infection, Neurological/systemic, and Tenderness, respectively. There were significant correlations between the number of positive UPOINT domains and total NIH-CPSI (r = 0.706, p<0.001, IPSS (r = 0.682, p<0.001 and IIEF-5 scores (r = 0.631, P = 0.007 in Chinese cohort. Except for patients age, symptom duration was associated with a significantly greater number of positive domains (r = 0.638, P  = 0.005. After adding an ED domain to create a modified UPOINT system, the correlation between the number of phenotypic domains and symptom severity was improved (0.706 to 0.844, p<0.001. CONCLUSIONS: The clinical applicability of using UPOINT phenotyping system has been validated in the Chinese patients with CP/CPPS. In our cohort, the number of positive domains was also correlated with ED symptoms and the significant association between the number of UPOINT domains and NIH-CPSI scores was further refined by adding a domain for ED. Our

  3. Differential Expression Analysis of Genic Male Sterility A/B Lines in Chinese Cabbage-Pak-Choi(Brassica Campestris ssp. chinensis Makino)

    Institute of Scientific and Technical Information of China (English)

    WANG Yong-qin; CAO Jia-shu; FU Qing-gong; YU Xiao-lin; YE Wan-zhi; XIANG Xun

    2003-01-01

    To determine differential expression of genic male sterility A/B lines in Chinese cabbage-pakchoi (Brassica campestris ssp. chinensis Makino var. communis Teen et Lee), we used the RNA fingerprinting technique, cDNA-AFLP analysis, in different developmental stages and different tissues. While no obvious differential expressions were observed in rosette leaves, florescence leaves, and scapes, some differential expressions were found in alabstrums of A/B lines and among leaves, scapes and alabstrums. We analyzed the alabstrums collected in different developmental stages with 10 primer combinations. We got a unique band between middle size alabstrums and large alabstrums in B line in one of the ten pair primers, and in another one pair, one band reflecting a higher gene-expression level in A line than that in B line was obtained. No unique bands were found with the other primer combinations. The bands reflecting different gene-expression level were confirmed by Northern hybridization. The results indicated that cDNA-AFLP was a suitable tool for studying differential expression of genic male sterility in plants. SDS-polyacrylamide gel electrophoresis patterns of soluble proteins further verified the difference in A/B lines.

  4. 大白菜细胞核雄性不育基因向卵圆型大白菜'60'的转育%Introgression of genic male sterile gene of Chinese cabbage into ovate ecotype Chinese cabbage variety '60'

    Institute of Scientific and Technical Information of China (English)

    关雪松; 许明

    2009-01-01

    根据大白菜复等位基因遗传假说,运用合成转育模式将大白菜'189'细胞核雄性不育基因转入基因型为msms的卵圆型白菜'160'中,获得了卵圆型白菜'160'的新甲型'两用系'及相应的不育系和保持系.%Based on the Multiple Allele Hypothesis of genie male sterility, the synthesis transferring method was used to transfer the gene of male sterility into the orbicular-ovate type Chinese cabbage variety '160', whose genotypes were msms by crossing, inbreeding, sibling and test crossing. New AB lines type I,new male sterile lines and their corresponding temporary maintainer lines of Chinese cabbage variety '160' were obtained from the transferred progenies of the Chinese cabbage variety '189'.

  5. Volunteering and the State

    OpenAIRE

    Hackl, Franz; Halla, Martin; Pruckner, Gerald J.

    2009-01-01

    This paper explores the capability of the state to affect the individual’s decision to work for free. For this purpose we combine individual-level data from the European and World Values Survey with macroeconomic and political variables for OECD member countries. Empirically we identify three channels for crowding out of voluntary labor. Firstly, an increase in public social expenditure decreases the probability that the individual will volunteer (fiscal crowding out). Secondly, a political c...

  6. Recruiting and Supporting Latino Volunteers.

    Science.gov (United States)

    Hobbs, Beverly B.

    This booklet is intended to help volunteer recruiters better understand characteristics of the Latino community that might impact volunteering. It also suggests strategies or steps to use in successfully recruiting and supporting Latino volunteers. Information is based on a study of Latinos and volunteerism conducted in Oregon in 1999. The…

  7. Special Report: Volunteers in Libraries

    Science.gov (United States)

    Savage, Noel

    1976-01-01

    Many New York librarians view volunteers as a serious job threat; their unions back them in their opposition to volunteers; and some administrators are afraid to launch volunteer programs during the budget crunch because of their probably adverse effect on staff morale. (Author)

  8. Enhancing Leadership Skills in Volunteers

    Science.gov (United States)

    Lockett, Landry L.; Boyd, Barry

    2012-01-01

    This article describes how professionals leading volunteers can purposefully work toward developing the "leadership identity" of individual volunteers. These concepts and the application of them are presented in the context of Cooperative Extension volunteer groups. Specific methods of developing the leadership identity and capacity of individual…

  9. Together we have fun: native-place networks and sexual risk behaviours among Chinese male rural-urban migrants.

    Science.gov (United States)

    Yang, Xiaozhao Yousef; Kelly, Brian C; Yang, Tingzhong

    2016-05-01

    Some scholars argue that the maintenance of social networks contributes to the lower prevalence of deviant behaviours and fewer adverse health effects among migrants. But others suggest that if migrants are embedded in homogeneous networks, such networks may enable the formation of a deviant subculture that promotes risk taking. Facing this dilemma, the present study investigates how native-place networks influence sexual risk behaviours (SRBs), specifically the pursuit of commercial sex and condomless sex with sex workers, for male rural-urban migrants. Using a multi-stage sample of 1,591 male rural-urban migrants from two major migrant-influx cities within China, we assessed migrants' general friend network ties and native place networks (townsmen in migrants' local networks) and tested their associations with SRBs. Multiple logistic regression analyses indicate that native-place network ties are associated with paying for sex (OR = 1.33, p rural-urban migrants are associated with SRBs because homogenous networks may serve as a platform for the emergence of a deviant subculture that promotes risk behaviours. A Virtual Abstract of this paper is available at: https://www.youtube.com/watch?v=3Wg20I6j8XQ.

  10. Strategy on the Competitive Power Development of Chinese Male Curling Team As the Results of Chinese Male Curling Team for the 2014 Winter Olympic Games in Sochi%中国冰壶男队竞技实力发展的策略--以2014年索契冬奥会中国冰壶男队比赛为例

    Institute of Scientific and Technical Information of China (English)

    马永俊; 许水生; 刘庆闯; 蒋立; 牛晓暹; 郭慧秋

    2014-01-01

    Competitive power of Chinese Male Curling Team is the most important guarantee of performance. Using the methods of literature,video observation and data analysis,this paper has an attribution analysis of the performance of Chinese Male Curling Team for the 2014 Winter Olympics in Sochi, it thinks the Chinese Male Curling Team performed well in the 2014 Winter Olympics in Sochi,has the power of world team,the specialization degree to create excellent successful experience for tacit teamwork, international training ways and teams,main factors restricting the power of Chinese Male Curling Team is the key ball is improperly handled,psychological quality is not enough good and lack of reserved talents. Chinese Male Curling Team has the ability for competing with the best team,but there is a certain distance from the world champion,in order to create a better,more stable performance,need to continue to take the international route,from cultivating the technical and tactical style of their team,strengthening psychological training and transportation and training talents to improve the overall competitive power.%中国冰壶男队的竞技实力是获得比赛成绩的最重保证。运用文献资料法、录像观察法和数据分析法对2014年索契冬奥会的中国冰壶男队比赛成绩进行归因分析,认为中国冰壶男队在2014年索契冬奥会的表现优异,已经具备世界强队的实力,创造优异成绩的成功经验为默契的团队配合、国际化的训练路线和队伍的专业化程度,制约中国冰壶男队实力的主要因素为运动员临场关键球处理不妥、心理素质不过硬和优秀后备人才匮乏。中国冰壶男队虽然已经具备了与头号强队同场竞技的能力,但要夺得世界冠军还有一定的距离,为了能够创造更好的、更稳定的成绩,需要继续走国际化路线,从培养自己队伍的战术技术风格、加强竞赛心理的训练及后备人才的培养与输

  11. Directional Transfer of a Genetic Male Sterile Line Derived from Flowering Chinese Cabbage ' Ever-Green'%‘四季油青’菜心核基因雄性不育系定向转育研究

    Institute of Scientific and Technical Information of China (English)

    王慧; 周鹏; 王玉刚; 冯辉

    2012-01-01

    为选育菜心雄性不育系解决其杂种优势利用中的制种手段问题,以复等位基因遗传的小白菜核基因雄性不育系‘00S107’为不育源,采用连续回交转育园艺学性状的同时,测交筛选基因型的方法,向‘四季油青’菜心中转育核不育基因,育成了不育株率和不育度均为100%的菜心核基因雄性不育系‘GMS203’.用菜心不育系试配的杂交组合,经品种比较试验筛选出2个综合性状优良的强优势组合.利用本项研究设计的核不育系定向转育方案,实现了不育性和园艺学性状的同时转育.%In order to create a procedure for utilization of heterosis in flowering Chinese cabbage, a breeding method for genetic male sterile line was carried out in the experiment. A multiple allele male sterile line of Chinese cabbage '00S107' was used as a source of male sterility, and recurrent backcrossing method was employed to transfer horticultural characters while the genotype was identified through test cross to transfer the male sterility to a male fertile line ' Ever-Green' of flowering Chinese cabbage. A new genetic male sterile line of flowering Chinese cabbage with 100% of male sterile plants and 100% of male sterility ' GMS203' was bred. The new male sterile line was applied to develop hybrid combinations. Two excellent combinations were selected through variety compare test. Based on the directional transfer program designed by the research according to the genetic characteristics of the male sterility, the male sterility and horticultural characters could be transferred simultaneously.

  12. Volunteers in the experience economy

    DEFF Research Database (Denmark)

    Gudiksen, Sune Klok

    2012-01-01

    and discussed. The Questions addressed is how to enlist, motivate and reward volunteers a long the way and how to manage and guide volunteers. Furthermore what kind of special relationship does the volunteer have in the making of the experience design and in the experience of that design. This paper combines......The use of volunteers is becoming more visible and important in the experience economy also in the light of the financial crisis. From a management perspective within both public and private organizations the use of volunteers is an important element partly because they strengthen the brand...... economy volunteers create a new set of dimensions, because they shift between being part of the experience producer and being one of the experience consumers. Volunteers are becoming increasingly more important in the experience economy as they contribute to the overall experience for users or customers...

  13. Pharmacokinetics of metformin hydrochloride and glipizide in fixed-dose combination in healthy Chinese volunteers%盐酸二甲双胍格列吡嗪胶囊的健康人体药动学研究

    Institute of Scientific and Technical Information of China (English)

    马智宇; 曲斌; 丁娅; 宋敏; 杭太俊

    2012-01-01

    Objective: To investigate the clinical plasma pharmacokinetics of metformin hydrochloride ( MET) and glipizide(GLP) in healthy Chinese volunteers post oral administration of fixed -dose combination capsules, each contains 250 mg metformin hydrochloride and 2. 5 mg glipizide. Methods;20 healthy Chinese volunteers were randomly divided into two groups. Group I was administrated with two incremental oral fixed -dose combination capsules(250 mg MET/2. 5 mg GLP, 750 mg MET/7. 5 mg GLP), respectively. Glipizide tablets(5 mg) , metformin hydrochloride capsules(500 mg), and fixed -doses combination capsules(500 mg MET/5 mg GLP) , were given to Group H with three - period, crossover study design, and multiple oral fix - doses combination capsules were also given to thisgroup. HPLC - UV was used for the determination of metformin and LC - MS/MS for glipizide. The main pharmaco-kinetic parameters and the statistic analysis results were evaluated by DAS 2.0 software. Results: After single oral dose of three incremental fixed -dose combination capsules (250 mg MET/2.5 mg GLP, 500 mg MET/5 mg GLP, 750 mg MET/7.5 mg GLP) and multiply oral doses of the fixed -dose combination capsules(500 mg MET/5 mg GLP), the main pharmacokinetic parameters of metformin hydrochloride were as follows; Cmax were (718 ± 122), (1179 ±308), (1494 ±174) and (979 ±268) ng·mL-1; Tmax were (1.7 ±0.63), (3.4 ±0.94), (2.4 ±0.70) and (3.9 ±1.4) h; AUC0_t, were (4519 ±606), (8646 ±2757), (10040 ±1501) and (8965 ±2200) ng · h · mL-1; t1/2 were (3.46 ±0. 34), (4.74 ±0. 80), (4.90 ± 1.42) and (4.99 ±0. 58) h, respectively. The main pharmacokinetic parameters of glipizide were as follows; Cmax were (294 ±63.4), (432 ±98.7), (641 ±76. 5) and (273 ±51.5) ng · mL-1; Tmax were (1.8 ±0.54), (1.9±0.78), (1.9±0.47) and (4.0±2.0) h; AUC0_t were (1642 ±340), (2788 ±994), (3508 ±758) and (2841 ± 1003) ng · h · mL-1; t1/2 were (4.04 ±0.53), (4.70 ±0.75), (3. 88 ±0. 77) and (6.46 ±5. 83

  14. Volunteer Team Management

    OpenAIRE

    Monych, Maria

    2015-01-01

    This thesis looked into volunteer team management in a project in AIESEC in Finland through the action research method. AIESEC in Finland is a non-profit non-government organization with a purpose of “peace and fulfilment of humankinds potential” through development of the youth’s future leadership. AIESEC was not a commissioning party; the project was the basis for the thesis without the supervision of the company. The thesis is based on a project that the author was in charge of, in ...

  15. Volunteers in the Heat

    Institute of Scientific and Technical Information of China (English)

    Li Zhijian

    2011-01-01

    BORN in a quiet city in south China,He Yulan's childhood memo-ries were right out of a traditional Chinese ink and wash painting:leaves swinging in the breeze,a crystal-clear river running through the town.Then last November she moved to Cameroon.

  16. Technical Performance and Enlightenment of Chinese Curling Male Team in 2014 World Championship%中国男子冰壶队在2014年世锦赛技术表现与启示

    Institute of Scientific and Technical Information of China (English)

    李洪臣; 许水生; 刘庆闯; 蒋立; 郭慧秋

    2014-01-01

    According to the tactical degree Chinese Curling Male Team in 2014 World Championships, analyzing the problems with the methods of literature,video observation,mathematical statistics. The results showed:In the world championships,the developing of Chinese team on the whole team and personal technology tends to be normal,performance is also relatively ideal,but immature competition psychology,unstable technology,Chinese male team ,many faults technology are found in Chinese male team. In order to get better performance of Chinese curling team,suggest Chinese curling male team to have an actively technical and tactical training;Strengthen the psychological training of competition,to create conditions for the realization of "translate practice to games". In addition, Reserved talents gaps of Chinese curling sports,the government should provide good conditions to help improve the level of professional curling talents,strengthen the construction of reserved talents for curling, supply new talents for Chinese curling team.%针对中国冰壶男队在2014年世锦赛中的技战术水平的发挥程度,采用文献资料法、录像观察法、数理统计法对比赛中出现的问题进行剖析。结果显示:本次世锦赛中,中国队在全队和个人技术上的发挥趋于正常,成绩也相对理想,但是中国男队存在竞赛心理不成熟、技术发挥不稳定、关键球失误频繁等问题。为了中国冰壶男队能够取得更好的成绩,建议中国冰壶男队积极进行技战术训练;加强竞赛心理训练,创造条件实现“以赛代练”。另外,我国的冰壶运动后备人才匮乏,政府应该提供良好条件帮助提高专业冰壶运动人才水平,加强冰壶运动后备人才建设,为冰壶国家队供给全新人才。

  17. Challenges in volunteering from cancer care volunteers perspectives.

    Science.gov (United States)

    Kamaludin, Kauthar Mohamad; Muhammad, Mazanah; Wahat, Nor Wahiza Abdul; Ibrahim, Rahimah

    2013-01-01

    The involvement of non-government organizations (NGOs) and support groups has helped strengthen public health services in addressing cancer care burden. Owing to the contribution of volunteers in cancer care, this article documents a qualitative study that examined challenges in attracting and retaining cancer care volunteers as part of the effort to develop a volunteer recruitment model. Data were collected through three focus group discussions involving 19 cancer support group members in Malaysia. Findings of the study revealed that mobility and locality appeared to be significant in Malaysian context, while the need for financial support and time flexibility are challenges faced by cancer support groups to attract and retain volunteers. The findings imply that cancer care initiatives can benefit from more local volunteers but at the same time these volunteers require flexibility and financial support to sustain their engagement.

  18. Characteristics of complex chromosomal rearrangement in Chinese male carriers and its impact on male fertility%中国男性复杂染色体重排特征及携带者生育情况分析

    Institute of Scientific and Technical Information of China (English)

    陈英剑; 张玮玮; 吴艳花; 孙晓明; 包慧; 胡成进

    2014-01-01

    目的:探讨中国人群中男性复杂染色体重排(CCR)携带者CCR类型及特征,并分析其对男性生育的影响.方法:用G带技术对因生育问题就诊的患者外周血淋巴细胞进行核型分析.检索1984年1月至2013年11月CNKI以及万方数据库有关CCR的文献,对有生育信息的男性CCR携带者的CCR类型及生育情况进行统计、分析.结果:1 625对夫妇中共检出男性CCR 2例;数据库中检索到有生育信息的男性CCR携带者47例.49例CCR中有3方重排17例(34.7%),双重双向易位17例(34.7%),特殊CCR 15例(30.6%),3种类型的发生率无明显差别(P>0.05).对临床资料的分析发现19例(38.8%)男性CCR携带者表现无精或少精子症导致的不育,其余30例(61.2%)男性CCR携带者的妻子共妊娠87次,自然流产或胚胎停育66次,占75.9%,畸胎死胎、早夭畸形儿8次(9.2%),生育表型正常后代13个(14.9%).对CCR累及的染色体及断裂点分析发现,累及6、7、8、11和16号染色体的CCR多出现不良妊娠,而累及10和14号染色体的CCR主要表现为生精障碍;断裂点1p22,1q25,2q31,2q33,5p13,5q35,6q23,8q13和20p13出现3次以上,其中断裂点1p22主要见于生精障碍者,断裂点2q31,5q35,和8q13多见反复流产.结论:CCR非常少见,表型正常的男性CCR携带者多因存在生育问题而被发现.男性CCR携带者不育的机率高、妻子出现异常妊娠的风险高,生育正常孩子的机会很小.此外,CCR累及的染色体及断裂点位置影响携带者的生育能力,某些染色体断裂点位置可能在配子形成过程中起关键作用.%Objective:To analyze the characteristics of complex chromosomal rearrangement (CCR) in Chinese male carriers and its influence on male fertility.Methods:Using the G band technique,we conducted karyotype analysis on the peripheral blood lymphocytes of 1 625 Chinese males with reproductive problems.We also searched CNKI and Wanfang database for CCR-related literature

  19. 大学生汉字自由联想的性别差异的实验研究%Experimental Study on Differences in the Free Association of Chinese Characters between Male and Female College Students

    Institute of Scientific and Technical Information of China (English)

    张建英; 姚本先

    2012-01-01

    目的:了解大学生汉字自由联想的性别差异.方法:运用实验法对110名大学生的汉字自由联想进行分析.结果:(1)男女大学生对音联和字联的回忆率存在差异;(2)男女大学生对感觉情绪词的回忆率存在差异;(3)男女大学生对反映心理的关键字的回忆率存在差异;(4)男女大学生自由联想汉字的偏旁部首存在差异.结论:汉字自由联想法可以用来分析大学生的思维、个性和心理健康状况.%Aim: to probe the differences in the free association of Chinese characters between male and female college students. Method: analyzing the free association of Chinese characters among 110 college students by an experimental study. Results: (l)There is difference in recall rale of thyme association and word association between male and female college students; (2)There is difference in recall rate of identifying emotional words between male and female college students; (3)There is difference in recall rate of key words reflecting psychological world between male and female college students; (4)There is difference in free association of radicals of Chinese characters between male and female college students. Conclusion: the free association of Chinese characters can be applied to analyze the college students' thoughts, personalities and psychological health status.

  20. Active oxygen metabolism in the floral buds and leaves of the new cytoplasm male sterile(CMS)line and its maintainer line of non-heading Chinese cabbage

    Institute of Scientific and Technical Information of China (English)

    YUAN Jianyu; HOU Xilin; ZHANG Changwei; YE Fan

    2007-01-01

    The cytoplasm male sterile(CMS)line and its maintainer line of the newly-bred non-heading Chinese cabbage were taken as experimental materials.The production rate of superoxide anion radical(O2-),contents of malondialdehyde(MDA)and hydrogen peroxide(H2O2),and the activities of superoxide dismutase(SOD),peroxidase(POD),catalase(CAT)as well as ascorbate peroxidase(APX)were determined in buds of different developmental stages and leaves during vegetative and florescence stages.As showed by the results,there were higher levels of MDA and H2O2 contents,higher 02- production rate and higher activities of SOD,POD,and CAT in the buds of the CMS lines than that in the buds of the fertile lines,while the APX activity was different from the other three enzymes above.There were differences in activities of protective enzymes in leaves but no significant differences in MDA contents and O2- production rate,which showed that the differences in metabolism of active oxygen between CMS and its maintainer were mainly apparent in reproductive organs.

  1. Evaluation of drug-drug interaction between henagliflozin, a novel sodium-glucose co-transporter 2 inhibitor, and metformin in healthy Chinese males.

    Science.gov (United States)

    Wang, Liupeng; Wu, Chunyong; Shen, Lu; Liu, Haiyan; Chen, Ying; Liu, Fang; Wang, Youqun; Yang, Jin

    2016-08-01

    1. Henagliflozin is a novel sodium-glucose transporter 2 inhibitor and presents a complementary therapy to metformin for patients with T2DM due to its insulin-independent mechanism of action. This study evaluated the potential pharmacokinetic drug-drug interaction between henagliflozin and metformin in healthy Chinese male subjects. 2. In open-label, single-center, single-arm, two-period, three-treatment self-control study, 12 subjects received 25 mg henagliflozin, 1000 mg metformin or the combination. Lack of PK interaction was defined as the ratio of geometric means and 90% confidence interval (CI) for combination: monotherapy being within the range of 0.80-1.25. 3. Co-administration of henagliflozin with metformin had no effect on henagliflozin area under the plasma concentration-time curve (AUC0-24) (GRM: 1.08; CI: 1.05, 1.10) and peak plasma concentration (Cmax) (GRM: 0.99; CI: 0.92, 1.07). Reciprocally, co-administration of metformin with henagliflozin had no clinically significant on metformin AUC0-24 (GRM: 1.09, CI: 1.02, 1.16) although there was an 11% increase in metformin Cmax (GRM 1.12; CI 1.02, 1.23). All monotherapies and combination therapy were well tolerated. 4. Henagliflozin can be co-administered with metformin without dose adjustment of either drug.

  2. Breeding and Utilization of the Genetic Male Sterile Line in Milk Chinese Cabbage%奶白菜核基因雄性不育系的选育与利用

    Institute of Scientific and Technical Information of China (English)

    徐巍; 冯辉

    2013-01-01

    In order to resolve the problem that cross breeding and production of hybrid in milk Chinese cabbage. According to the hypothesis of multiple allele inherited genetic male sterile, A genetic male sterile line of Chinese cabbage with green stipe 00S107 was used as a source of male sterility,and methods of continuous backcross-ing and identifying of the genotypes were applied to transfer the male sterile line of milk Chinese cabbage. Hybridized combinations were obtained by the male sterile line as female parent cross with excellent self-line and we analysed the hybrid vigor. A new genetic male sterile line GMS3 with 100% male sterile plants and 100% male sterility was obtained. Two excellent hybridized combinations GMS3 × B1 ,GMS3×B2 were selected, whieh is uniform and superior to CK in yield. Directional transfer model which transfer sterile gene and horticultural characters at the same time resolved the puzzle that breeding and utilization of the genetic male sterile line in milk Chinese cabbage.%为解决奶白菜杂交种生产中的杂交制种手段问题,配制优良杂交种.以核不育“复等位基因遗传”假说为指导,以青梗白菜核基因雄性不育系00S107作不育源,采用连续回交转育同时测交鉴定基因型的方法,定向转育奶白菜核基因雄性不育系.并利用转育成的不育系与奶白菜优良自交系配制杂交组合,进行了杂种优势分析.选育出园艺学性状与目标品系相似,具有100%不育株率和不育度的奶白菜核基因雄性不育系GMS3,筛选出2个产量高、整齐度高的优异杂交组合GMS3×B1、GMS3×B2.定向转育模式兼顾了不育基因和园艺学性状的转育,解决了奶白菜核不育系转育和利用的难题.

  3. Glycemic index and glycemic load of selected Chinese traditional foods

    Institute of Scientific and Technical Information of China (English)

    Stephen; Heung-sang; Wong

    2010-01-01

    AIM:To determine the glycemic index(GI)and glycemic load(GL)values of Chinese traditional foods in Hong Kong.METHODS:Fifteen healthy subjects(8 males and 7 females)volunteered to consume either glucose or one of 23 test foods after 10-14 h overnight fast.The blood glucose concentrations were analyzed immediately before,15,30,45,60,90 and 120 min after food consumption using capillary blood samples.The GI value of each test food was calculated by expressing the incremental area under the blood glucose respon...

  4. Volunteers in the Heat

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Teaehing Chinese in Cameroon BORN in a quiet city stu- in south China,He Yulove lan’s childhood memo-Peng ries were right out of-five a traditional Chinesenese ink and wash painting:une, leaves swinging in the!" breeze,a crystal-clear river running through the town.Then last Noson’s vember she moved to d for Cameroon,the

  5. Psychosocial Differences between Elderly Volunteers and Non-Volunteers.

    Science.gov (United States)

    Hunter, K.I.; Linn, Margaret W.

    1980-01-01

    Volunteer workers over sixty-five were compared to retired elderly who did not engage in work activity. Volunteers had significantly higher degree of life satisfaction, stronger will to live, and fewer symptoms of depression, anxiety, and somatization. No differences were found on demographics or background. (Author)

  6. Volunteering for charity: pride, respect, and the commitment of volunteers.

    Science.gov (United States)

    Boezeman, Edwin J; Ellemers, Naomi

    2007-05-01

    This study builds upon and extends the social-identity-based model of cooperation with the organization (T. R. Tyler, 1999; T. R. Tyler & S. L. Blader, 2000) to examine commitment and cooperative intent among fundraising volunteers. In Study 1, structural equation modeling indicated that pride and respect related to the intent to remain a volunteer with an organization, and that this relation was mediated primarily by normative organizational commitment. In Study 2, structural equation modeling indicated that the perceived importance of volunteer work was related to pride, that perceived organizational support related to the experience of respect, and that pride and respect mediated the relation between perceived importance and support on the one hand and organizational commitment on the other. Overall, the results suggest that volunteer organizations may do well to implement pride and respect in their volunteer policy, for instance to address the reliability problem (J. L. Pearce, 1993).

  7. The consideration of emotional intelligence abilities in event volunteers

    Directory of Open Access Journals (Sweden)

    Reza Andam

    2012-09-01

    Full Text Available The measurement of emotional intelligence abilities is one of the new subjects and important in human behavior studies. According to this matter, purpose of this research is consideration of emotional intelligence abilities in public sport events volunteers in 2011. For this purpose, Bradbury and Cruise's standard questionnaire was completed by present volunteers in event (n=80. The results indicated that 4 levels of emotional intelligence in volunteers are higher than expectational average significantly (p<0.01. Also, priority of emotional intelligence abilities indicated that self-awareness is first priority and social awareness, relationship management and self-management are second, third and fourth priorities in volunteers. Finally, in the basis of parameter, results stated that there is no difference between male and female volunteers emotional intelligence in first Olympia of public sport. According to results of present research and advantages of attention to emotional intelligence and human behavior in organizations, it recommended sport events managers to be more sensitive relative to human behavior abilities in human behavior abilities in human resource (volunteers under his management. At least, result of this meditation in student's sport is recruitment and development of motivated volunteers for continuous attendance in sport events.

  8. To volunteer or not to volunteer? A cross-country study of volunteering

    OpenAIRE

    Sardinha, Boguslawa Maria Barszczak; Pires, Cesaltina Pacheco

    2011-01-01

    Comunicação apresentada em 5th Annal Meeting of the Portuguese Economic Journal - Aveiro, 8-9 July 2011 This paper uses data from the 4th wave of the European Values Survey (EVS) to inves- tigate the factors that in uence the decision to participate in volunteering activities, con- sidering both volunteering in general as well as volunteering in particular types of activities. Like previous studies we include several socioeconomic and demographic variables. However our study al...

  9. The influence of physique on dose conversion coefficients for idealised external photon exposures: a comparison of doses for Chinese male phantoms with 10th, 50th and 90th percentile anthropometric parameters.

    Science.gov (United States)

    Lv, Wei; He, Hengda; Liu, Qian

    2017-03-22

    For evaluating radiation risk, the construction of anthropomorphic computational phantoms with a variety of physiques can help reduce the uncertainty that is due to anatomical variation. In our previous work, three deformable Chinese reference male phantoms with 10th, 50th and 90th percentile body mass indexes and body circumference physiques (DCRM-10, DCRM-50 and DCRM-90) were constructed to represent underweight, normal weight and overweight Chinese adult males, respectively. In the present study, the phantoms were updated by correcting the fat percentage to improve the precision of radiological dosimetry evaluations. The organ dose conversion coefficients for each phantom were calculated and compared for four idealized external photon exposures from 15 keV to 10 MeV, using the Monte Carlo method. The dosimetric results for the three deformable Chinese reference male phantom (DCRM) phantoms indicated that variations in physique can cause as much as a 20% difference in the organ dose conversion coefficients. When the photon energy was physiques. Hence, it is difficult to predict the conversion coefficients of the phantoms from the anthropometric parameters alone. Nevertheless, the complex organ conversion coefficients presented in this report will be helpful for evaluating the radiation risk for large groups of people with various physiques.

  10. Managing Library Volunteers, Second Edition

    Science.gov (United States)

    Driggers, Preston; Dumas, Eileen

    2011-01-01

    Volunteers are essential to a successful library program--and at a time when deep budget cuts are the norm, there are many libraries that depend on the help of dedicated volunteers, who do everything from shelving books to covering the phones. Whether these are friends, trustees, or community members, managing them effectively is the key to…

  11. My Days as a Volunteer

    Institute of Scientific and Technical Information of China (English)

    顾晓玲; 杨梦倩; 许文侠; 陈丽敏; 陈丽琼; 陈昊; 李雯

    2009-01-01

    Volunteer, a word derived from Latin, carries the meaning of "will". A volunteer is someone who works for a community or for the benefit of environment. There are various forms of voluntary work including "serving food at the local homeless shelter,

  12. 中国不同性别亚健康人群差异分析%Sub-health status in male and female Chinese populations

    Institute of Scientific and Technical Information of China (English)

    王秀; 何裕民

    2012-01-01

    Objective To explore different sub-health status between populations of different gender. Methods A cross-sectional study was conducted to analyze sub-health status of 13 439 people in 8 provinces in China. Results Sub-health status of male was much more expressed in sexual life( male:5. 22 ± 1.06,femal:4.92 ±0. 96), while female was much more expressed in physical and psychological symptoms ( physical symptoms score for male: 104. S3 ± 20.47, for female; 110.27 ±20.90:psychological score for male:53.63 ±8.04,for female:55. 89 ±7. 88;P0.05). For somatic symptoms, the men had a hypo-immunity and were susceptible to cold or with a longer period of the disease compared to the woman (P < 0.001). While women felt tired easily and frequently had digestive problem, poor sleep, autonomic nervous disorders, allergy, aging apperance, a variety of pain or discomfort, constipation, and frequent drug usage (P < 0.001). In psychological symptoms, women showed more depression, anxiety problem,memory loss,and severe stress than men(P<0.001 for all). There was a significant difference in sexual satisfaction score between the men and the women with sub-health (P <0.01) and the men were more likely to worry about sexuality than women (P < 0. 01). Conclusion The symptoms of sub-health are different between men and-women in Chinese population.%目的 探讨不同性别亚健康状态人群症状表现差异.方法 采用流行病学横断面调查方法对中国8个省市13 439名各类人群进行亚健康状态调查分析.结果 男、女性亚健康症状性生活得分分别为(5.22±1.06)、(4.92±0.96)分,躯体症状分别为(104.53±20.47)、(110.27±20.90),心理方面分别为(53.63±8.04)、(55.89±7.88)分,差异均有统计学意义(P<0.01);社会适应性方面差异无统计学意义(P>0.05);在躯体症状方面,男性免疫力低下,易患有感冒或感冒不易痊愈;与男性比较,女性易感到疲劳,消化系统不适多见,睡眠差,多有植

  13. Genetic polymorphisms in cytochrome P4502E1,alcohol and aldehyde dehydrogenases and the risk of esophageal squamous cell carcinoma in Gansu Chinese males

    Institute of Scientific and Technical Information of China (English)

    Yan-Mei Guo; Qin Wang; Yan-Zhen Liu; Huei-Min Chen; Zhi Qi; Qing-Hong Guo

    2008-01-01

    AIM:To evaluate the association between genetic polymorphisms in CYP2E1,ALDH2 and ADHIB and the risk of esophageal squamous cell carcinoma (ESCC) in a high risk area of Gansu province,in Chinese males.METHODS:A case-control study was conducted to investigate the genetic polymorphisms of these enzymes (CYP2EI*cl/*c2,ALDH2*I/*2 and ADHIB "1/'1genotypes).A total of 80 esophageal cancer cases and 480 controls were recruited.RESULTS:Compared with controls,cases had a greater prevalence of heavier alcohol consumption (53.8% vs 16.2%) and a higher proportion of alcohol drinkers with > 30 drink-years (28.8% vs 13.5%).Heavier alcohol consumption and alcohol drinking with > 30 drink-years increased the risk of ESCC,with ORs (95% CI)of 3.20 (1.32-9.65) and 1.68 (0.96-3.21).CYP2E1(*cl/*cl),ALDH2 ('1/'2) and ADHIB (*1/*1) genotype frequencies were higher among patients with squamous cell carcinomas,at a level close to statistical significance (P = 0.014; P = 0.094; P = 0.0001 respectively).There were synergistic interactions among alcohol drinking and ALDH2,ADHIB and CYP2E1 genotypes.The risk of the ESCC in moderate-to-heavy drinkers with an inactive ALDH2 encoded by ALDH2*I/*2 as well as ADHIB encoded by ADHIB "1/'1 and CYP2E1 encoded by CYP2E1 *cl/*cl was higher than that in the never/rare-to-light drinkers with an active ALDH2 ('1/'1 genotype)as well as ADHIB ('1/'2 + *2/*2) and CYP2E1 (*c1/*c2+ *c2/*c2) genotypes,with a statistically significant difference; ORs (95% CI) of 8.58 (3.28-22.68),27.12(8.52-70.19) and 7.64 (2.82-11.31) respectively.The risk of the ESCC in moderate-to-heavy drinkers with ALDH2('1/'2) combined theADHIB ('1/'1) genotype orALDH2('11"2) combined the CYP2E1 (*cl/*cl) genotype leads to synergistic interactions,higher than drinkers with ALDH2 (* 1/* 1) + ADHIB ('1/'2 + *2/*2),ALDH2 (* 1/* 1)+ CYP2E1 (*cl/*c2 + *c2/*c2) respectively,ORs (95%CI) of 7.46 (3.28-18.32) and 6.82 (1.44-9.76) respectively.Individuals with the ADHIB combined the CYP2E1genotype

  14. 注射用头孢他啶/他唑巴坦(3∶1)在中国健康人体的单剂量药代动力学研究%Pharmacokinetics of ceftazidime/tazobactam (3∶1) after single intravenous infusion administration in Chinese healthy volunteers

    Institute of Scientific and Technical Information of China (English)

    孙路路; 单爱莲; 吕媛

    2012-01-01

    目的 评价单剂量头孢他啶/他唑巴坦注射剂(3∶1)在中国健康人体的药代动力学.方法 12名健康男性受试者先后接受单方头孢他啶1800 mg、他唑巴坦600 mg和复方头孢他啶/他唑巴坦1800/600 mg,用高效液相色谱-紫外检测法测定血药浓度、尿液浓度,用DAS程序求药代动力学参数.结果 血药浓度-时间曲线符合二房室模型.主要药代动力学参数分别如下:给药后单方和复方头孢他啶的Cmax为( 130.64±12.05),(136.03±15.27) mg·L-1;t1/2β为(1.50±0.25),(1.36±0.62)h;AUC0-t为(271.26 ±44.23),(285.36±42.87)mg·h·L-1.单方和复方他唑巴坦的Cmax为(23.72±8.06),(24.52±6.86)mg·L-1;t1/2β为(0.85±0.36),(0.89±0.45)h;AUC0-t为(28.06±12.18),(30.41±13.74) mg·h·L-1.单方和复方头孢他啶24h累积排泄率分别为(73.8±18.5)%和(79.0±23.0)%;单方和复方他唑巴坦24 h尿药累积排泄率分别为(66.1±27.0)%和(66.2±36.5)%.结论 头孢他啶与他唑巴坦两药联合应用,并不影响它们各自的体内过程.%Objective To investigate pharmacokinetics of ceftazidime / tazobactam ( 3: 1) after single intravenous infusion administration in Chi-nese healthy volunteers. Methods Twelve healthy male volunteers re-ceived ceftazidime 1800 mg, tazobactam 600 mg and ceftazidime/ tazobactam 1800/600 mg. The concentrations of ceftazidime and tazobac-tam in plasma and urine were assayed by HPLC - UV method. The phar-macokinetic parameters of ceftazidime and tazobactam were caculated by DAS software. Results It was found that concentration - time curves of ceftazidime and tazobactam were fitted to two compartment model. The main pharmacokinetic parameters were as follows; ceftazidime in single and combination preparations Cmax were (130. 64 ± 12. 05) , (136. 03 ± 15.27) mg · L-1;t1/2β were (1. 50 ±0. 25), (1.36 ± 0. 62) h; AUC0-t were (271. 26 ±44. 23), (285. 36 ±42. 87) mg · h · L-1. Tazobactam in single and combination preparations

  15. 大白菜雄性不育复等位基因的发现与利用%Discovery and Utilization of the Multiple Allele Male Sterility in Chinese Cabbage

    Institute of Scientific and Technical Information of China (English)

    冯辉; 刘志勇; 李承彧; 王玉刚; 冀瑞琴

    2011-01-01

    The discovery and its verification of the Multiple Allele Male Sterility in Chinese Cabbage were reviewed. The utilization models for the multiple allele male sterile line was put forward. Progresses in the developments of the male sterile lines in the varieties and sub-varieties of Chinese cabbage, and mapping of the male sterile gene were presented.%介绍了大白菜雄性不育复等位基因的发现过程,以及"大白菜核基因雄性不育复等位基因遗传假说"的验证试验结果.提出了不育系的应用模式,介绍了品种、变种和亚种间复等位基因型雄性不育系转育研究结果,以及不育基因分子标记、定位及表达的研究进展.

  16. Volunteer Program for the WSIS

    CERN Multimedia

    2003-01-01

    PALEXPO, GENEVA, from 4 - 13 December Are you concerned by the digital divide between the North and the South? Would you like to contribute personally to the success of the World Summit on the Information Society (WSIS), in particular the activities of civil society? Join the team of volunteers and/or offer accommodation to an international volunteer! Contact: Charlotte (Project Coordinator WSIS) Kathy (Volunteer Coordinator) ICVolunteers PO Box 755 - CH-1211 Genève 4 Phone: +41 22 800 1436 - Fax: +41 22 800 14 37 E-mail: charlotte@icvolunteers.org kathy@icvolunteers.org For further information, please consult the website: http://www.icvolunteers.org

  17. What do women gain from volunteering? The experience of lay Arab and Jewish women volunteers in the Women for Women's Health programme in Israel.

    Science.gov (United States)

    Daoud, Nihaya; Shtarkshall, Ronny; Laufer, Neri; Verbov, Gina; Bar-El, Hagar; Abu-Gosh, Nasreen; Mor-Yosef, Shlomo

    2010-03-01

    Ambiguous feelings regarding women engaging in formal volunteering and concerns about their exploitation might explain the dearth of studies regarding the volunteering benefits specifically experienced by low socioeconomic status women. The current study examined benefits of volunteering among women participating in Women for Women's Health (WWH), a lay health volunteers (LHV) programme implemented in Jewish and Arab communities in Israel, and aiming at empowering such women to become active volunteers and promote health activities in their communities. Two years after the introduction of WWH in each community, all 45 Jewish and 25 Arab volunteers were contacted by phone and invited to participate in the focus group discussions. Five focus group discussions were conducted with 25/42 Jewish volunteers in 2003 and four with 20/25 Arab volunteers in 2005. The other volunteers could not attend the scheduled meetings or became inactive for personal reasons. Four benefit categories were identified in both ethnic groups: 1. Personal benefits of having increased knowledge, feeling self-satisfaction, mastering new skills and performing healthy behaviours; 2. Group-social benefits of social support and sense of cohesion; 3. Purposive benefits of achieving the WWH mission and goals; 4. Sociopolitical benefits of learning to accept the other and experiencing increased solidarity. However, the relatively less privileged Arab volunteers enumerated more benefits within the personal and purposive categories. They also identified the unique sociocultural category of improving women's status in the community by creating a legitimate space for women by public sphere involvement, traditionally solely a male domain. We conclude that volunteering in community-based health promotion programmes can be an empowering experience for lay women without being exploitative. Positive volunteering benefits will be even more discernable among underprivileged women who enjoy fewer opportunities in

  18. Validation of a HPLC-ESI MS/MS method for the determination of clonidine in human plasma and its application in a bioequivalence study in Chinese healthy volunteers.

    Science.gov (United States)

    Zhuang, Jialang; Chen, Jiangying; Wang, Xueding; Pang, Yin; Bi, Huichang; Huang, Lihui; Zeng, Guixiong; Liao, Xiaoxing; Ma, Zhongfu; Chen, Xiao; Zhong, Guoping; Huang, Min; Zhao, Xianglan

    2015-10-01

    A rapid and sensitive liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method to determine clonidine in human plasma was developed and fully validated. Sample preparation was involved an one-step extraction with diethyl ether. Donepezil was employed as the internal standard (IS). Chromatographic separation was performed on a Hypersil BDS C18 column (i.d. 2.1 × 50 mm, particle size 3μm) with a mobile phase of methanol-water (containing 0.1% formic acid; 60:40, v/v) at a flow rate of 200 μL/min. The peaks were detected by mass spectrometry using the electrospray ion source in selected reaction monitoring mode. The extraction recovery was 72.53-85.25%. The method was found to be linear in a concentration range of 0.02-6.00 ng/mL and the lower limit of quantification was 0.02 ng/mL. The within- and between-batch precisions at three concentrations were 4.33-16.47 and 7.24-17.24% with accuracies of -2.47-10.91 and 1.86-10.19%, respectively. This validated method was successfully used for a bioequivalence study of two clonidine transdermal patches on healthy volunteers. The results suggested that the test formulation of clonidine patch met the regulatory criterion for bioequivalence to the reference formulation, but a larger sample size should be needed for the estimation of bioequivalence.

  19. Brassica chinensis (L.) transformation of male steriliry from non-heading Chinese cabbage GMS%以不结球白菜细胞核基因雄性不育系向乌塌菜作物转育

    Institute of Scientific and Technical Information of China (English)

    南海龙

    2014-01-01

    试验根据大白菜复等位基因遗传假说,以不结球白菜细胞核基因雄性不育系为不育源,向乌塌菜作物中转育,并对细胞核雄性不育基因转育机制进行系统研究。获得如下结果:设计遗传转育模式,完成乌塌菜4个世代雄性不育的转育工作,获得含有乌塌菜基因型的甲型“两用系”、临时保持系和雄性不育系。%In this experiment, based on the multiple allele inheritance hypothesis of Chinese cabbage, male steriliry of non-heading Chinese cabbage GMS was transferred to Brassica chinensis (L.). The experiment has been systematically investigated the transformation mechanism of genetic male sterility. Results showed that four male sterile generations of Brassica chinensis (L.) could be achieved according to the inheritance transformation mode.

  20. 中国男子冰壶队与欧美强队扫冰技术能力对比--以2014男子冰壶世界锦标赛为例%Technical Ability Comparative of Sweeping of Chinese Curling Male Team and Euro-American Curling Strong Teams--An Example of 2014 World Curling Male Championship

    Institute of Scientific and Technical Information of China (English)

    马永俊; 牛晓暹; 臧荣海; 许水生

    2014-01-01

    冰壶运动中扫冰技术是对比赛过程产生影响的重要因素。利用文献资料、现场观察等研究方法,对2014男子冰壶世界锦标赛中国队与欧美强队扫冰技术能力进行对比分析,从中找出中国男子冰壶队与欧美强队在扫冰技术能力上的差别,提高中国男子冰壶队竞赛成绩。结果表明:扫冰技术在冰壶比赛中极为重要,对比赛的过程产生重要的影响;中国队与欧美强队相比扫冰技术能力相对较弱;在队投壶技术的稳定性方面中国队比欧美强要好。建议中国队在扫冰技术方面进行针对性训练,加强对冰壶运动轨迹产生影响因素的综合理解认识;增强扫冰技术团队配合能力;提高扫冰技术专项力量训练。%Sweeping is an important factor to influence a process of a game in curling,with the use the methods of literature,field observation and so on. By comparing analyzing on the sweeping technical ability of Chinese curling male team and Euro-American Curling strong teams,find out the difference of technical ability of Chinese curling male team and Euro-American Curling strong teams,to improve the performance of Chinese curling male team. The results show:sweeping technology is very important in curling competition,and have an important impact on the process of games;The sweeping technical ability of Chinese Team is relatively weak to Europe-American strong teams;The stability of throwing curling technology of Chinese Team is better than Europe-American strong teams. Suggest Chinese to have targeted training in sweeping technology, strengthen the comprehensive understanding of curling motion track;Enhance the cooperated ability of sweeping technology;Improve the special strength training of sweeping technology.

  1. Bioequivalence of metformin hydrochloride tablets in Chinese healthy volunteers%盐酸二甲双胍片在中国健康人体的生物等效性

    Institute of Scientific and Technical Information of China (English)

    邱相君; 孙永健; 刘涛; 刘心霞; 袁世英; 陈汇

    2012-01-01

    Objective To evaluate the bioequivalence of two domestic metformin hydrochloride tablets in healthy volunteers. Methods A single oral dose (1. 0 g of test and reference formulation) was given to 20 healthy volunteers in a randomized crossover study. The concentrations of metformin hydrochloride in plasma were determined by HPLC. The bio-availability and bioequivalence of two formulations were evaluated by DAS 2. 0 software, then the bioequivalence was judged. Results After a single dose, the pharmacokinetic parameters for tested and reference metformin hydrochloride were as follows: Cmax were (2. 83 ± 0. 53 ), (2.57±0.57) mg , L-1; Twere (1.55 ±0. 39) , (t. 63 ±0. 36) h; t1/2 were ( 3. 70 + 1. 76), (3. 36 ± 0. 72) h; AUC0_24 were (10. 20 ± 1. 95), (9. 71 ± 2. 56) mg · h · L-1, respectively. The 90% confidential interval of AUC0-24, AUC0-∞ and Cmax of test formulation were 99. 1% -114.6% , 99. 1% -113. 8% and 100.6% -110.4% , respectively. The relative bioavailability of test to reference formulation was (108. 3 ± 20. 5 ) % . Conclusion The test and reference metformra hydrochloride were bioequivalence.%目的 评价2种国产盐酸二甲双胍片(口服降糖药)在中国健康人体的生物等效性.方法 20名健康男性受试者随机交叉单剂量口服盐酸二甲双胍片试验药物和对照药物,各1.0 g.用高效液相色谱法测定血浆中盐酸二甲双胍的浓度,用DAS 2.0软件计算药代动力学参数,并对2种药物进行生物等效性评价.结果 试验药物和对照药物的主要药代动力学参数如下:Cmax为(2.83±0.53),(2.57±0.57) mg· L-1;Tmax为(1.55±0.39),(1.63±0.36)h;t1/2为(3.70±1.76),(3.36±D.72) h;AUC0-24为(10.20±1.95),(9.71±2.56) mg·h·L-1.AUC0-24、AUC0-∞、Cmax的90%可信区间分别为99.1% ~114.6%、99.1% ~ 113.8%和100.6%~110.4%.试验药物相对于对照药物的生物利用度F为(108.3±20.5)%.结论 试验药物和对照药物生物等效.

  2. 花心大白菜核基因雄性不育系的创制%Studies on Breeding of Genetic Male Sterile Line in Chinese cabbage (Brassica rapa ssp.Pekinensis)

    Institute of Scientific and Technical Information of China (English)

    杨宁; 王昊; 冯辉

    2011-01-01

    以白菜核基因雄性不育系(Msms)为不育源,以花心大白菜宫古花蕊Y02(MsfMsf)为轮回亲本,采用连续回交,杂交和自交的转育方法,成功地将不育基因转入到可育品系YO2中,育成了不育度和不育株率均为100%,植物学性状与Y02相近的新核不育系GMS4.%A multiple allele inherited genetic male sterile line of Chinese cabbage was used as the source of male sterility, backcrossing, crossing and selfing were applied to transfer the male sterility to male fertile line Y02. The new male sterile line GMS4, which contained similar botanical characters with Y02 and the sterility frequency and sterility degree were all 100%, was obtained successfully.

  3. Studies on the Breeding of the Genetic Male Sterility Lines of‘Heiye’Chinese Cabbage with Anti-Clubroot%‘黑叶’大白菜抗根肿病雄性不育系转育研究

    Institute of Scientific and Technical Information of China (English)

    李林; 沈向群; 郭艳锋; 王菲菲; 洪雅婷; 陈永浩

    2013-01-01

    In order to breed new Chinese cabbage variety with anti-clubroot, according to the genetic hypothesis of multi-allele and the conclusion that the anti-clubroot is controlled by a dominant nuclear gene in Chinese cabbage, the resistant gene against clubroot disease and the sterile genes were transferred to‘Heiye’ Chinese cabbage with cycle male parents using anti-clubroot sterile plants of AB lines (type Ⅰ) of Chinese cabbage as resistance resources and infertility resources. By means of crossing, consecutive backcrossing, self-crossing, test cross, sib-mating and resistance inoculation screening, etc., anti-clubroot new AB lines (type Ⅰ) and temporary maintainer lines of‘Heiye’Chinese cabbage were achieved. Breeding the male sterility lines of‘Heiye’Chinese cabbage with anti-clubroot can lay the foundation for selection of new varieties in anti-clubroot.%为选育抗根肿病大白菜新品种,根据“复等位基因”遗传假说及大白菜对根肿病的抗性由1对显性核基因控制的结论,以抗根肿病大白菜甲型雄性不育“两用系”的不育株为抗源和不育源,以‘黑叶’大白菜为轮回父本,经过杂交、连续回交、自交、测交、兄妹交和抗病接种筛选鉴定等方法,将抗根肿病基因和核不育基因导入‘黑叶’大白菜中,获得抗根肿病‘黑叶’大白菜新甲型雄性不育“两用系”和“临时保持系”。抗根肿病的大白菜雄性不育系的育成,为抗根肿病新品种选育提供参考。

  4. Exploring Volunteering of Committed Young Catholics

    Science.gov (United States)

    Webber, Ruth

    2012-01-01

    This article reports on a study of volunteer levels of Catholics from various World regions who attended an international youth Catholic festival. Volunteering levels, types of volunteering, reason for volunteering, Catholic group membership and pro-social values are analysed. An online survey was administered five months after the Festival to…

  5. Volunteering among Young People. Fact Sheet

    Science.gov (United States)

    Lopez, Mark Hugo; Marcelo, Karlo Barrios

    2007-01-01

    This fact sheet presents information on the frequency of volunteering, trends in volunteering, and the organizations for which young people volunteer, utilizing data from multiple sources. Unlike many surveys, it shows that volunteering rates among young people are generally higher than they are among adults 26 and older. Findings of the Civic and…

  6. Volunteering Among Young People. CIRCLE Fact Sheet.

    Science.gov (United States)

    Lopez, Mark Hugo

    2004-01-01

    Volunteering rates among young people are generally higher than they are among adults 26 and older. However, measuring volunteer rates among all adults is a difficult task. In recent years, efforts at measuring volunteering have produced widely different estimates, largely because of the methods employed to measure volunteering. For example, the…

  7. Volunteering among High School Students. Fact Sheet

    Science.gov (United States)

    Marcelo, Karlo Barrios

    2007-01-01

    This fact sheet explores volunteering among high school students, ages 16-18. Overall, volunteering among high school students was down slightly in 2006 as compared to 2005. Additional information includes types of volunteer organizations and activities, and ways that high school students become involved in these activities. Volunteer rate vary by…

  8. Parallel Volunteer Learning during Youth Programs

    Science.gov (United States)

    Lesmeister, Marilyn K.; Green, Jeremy; Derby, Amy; Bothum, Candi

    2012-01-01

    Lack of time is a hindrance for volunteers to participate in educational opportunities, yet volunteer success in an organization is tied to the orientation and education they receive. Meeting diverse educational needs of volunteers can be a challenge for program managers. Scheduling a Volunteer Learning Track for chaperones that is parallel to a…

  9. Knowledge and Attitude of Iranian Red Crescent Society Volunteers in Dealing with Bioterrorist attacks

    Directory of Open Access Journals (Sweden)

    Seyed Ali Bahreini Moghadam

    2016-01-01

    Full Text Available Introduction: Bioterrorism is a worldwide problem and has been the focus of attention during recent decades. There is no precise information on the knowledge, attitude, and preparedness of Iranian Red Crescent volunteers in dealing with bioterrorism. Therefore, the present study aimed to evaluate the above-mentioned parameters in Mahabad Red Crescent Society volunteers. Methods: In this prospective cross-sectional study, the knowledge of 120 volunteers was evaluated and rated as poor, moderate, and good. In addition, attitude of the volunteers and preparedness of Mahabad Red Crescent Society was rated as inappropriate and appropriate using a questionnaire. Results: The mean age of volunteers was 32.0 ± 8.2 years (62.5% male. 2 (1.7% volunteers had good knowledge while 94 (78.3% had no knowledge regarding bioterrorist attack management. Only 1 (0.8%  volunteer had appropriate attitude and 6 (5.0% stated their preparedness for being sent out to the crisis zone. 116 volunteers (96.7% indicated that Mahabad Red Crescent Society has an inappropriate level of preparedness to encounter bioterrorist attacks. Conclusion: The findings of the present study showed poor knowledge and inappropriate attitude of Mahabad Red Crescent Society volunteers in encountering probable bioterrorist attacks. Furthermore, the Red Crescent Society of this town had an inappropriate level of preparedness in the field of bioterrorism from the viewpoint of the studied volunteers.

  10. Pharmacokinetics of oral and intravenous melatonin in healthy volunteers

    DEFF Research Database (Denmark)

    Andersen, Lars Peter Holst; Werner, Mads Utke; Rosenkilde, Mette Marie

    2016-01-01

    BACKGROUND: The aim was to investigate the pharmacokinetics of oral and iv melatonin in healthy volunteers. METHODS: The study was performed as a cohort crossover study. The volunteers received either 10 mg oral melatonin or 10 mg intravenous melatonin on two separate study days. Blood samples were...... collected at different time points following oral administration and short iv infusion, respectively. Plasma melatonin concentrations were determined by RIA technique. Pharmacokinetic analyses were performed by "the method of residuals" and compartmental analysis. The pharmacokinetic variables: k a, t 1....../2 absorption, t max, C max, t 1/2 elimination, AUC 0-∞, and bioavailability were determined for oral melatonin. C max, t 1/2 elimination, V d, CL and AUC 0-∞ were determined for intravenous melatonin. RESULTS: Twelve male volunteers completed the study. Baseline melatonin plasma levels did not differ...

  11. 紫菜薹核基因雄性不育系的创制与利用%Breeding and Utilization of the Genetic Male Sterile Line in Purple Stalk Chinese Cabbage

    Institute of Scientific and Technical Information of China (English)

    冯辉; 娄广学

    2011-01-01

    以复等位基因遗传的白菜核基因雄性不育系00S107为不育源,采用连续回交转育同时测交筛选基因型的方法,向紫菜薹自交系XA500中转育核不育基因,育成了园艺学性状与XA500相近,不育株率和不育度均达到100%的紫菜薹雄性不育系GMS500.用该不育系配成的杂交组合整齐一致,园艺学性状优异,单位面积产量显著高于对照品种'紫婷11号'.%In order to solve the problems in the transfer and utilization of genie male sterile line in purple stalk Chinese cabbage, '00S107' which is a multiple allele inherited genetic male sterile line was used as a source of male sterility in Brassica campestris L. Ssp. Chinensis var. Purpurca Hort. Methods of crossing and backcrossing were applied to transfer the male sterility to a male fertile line' XA500' - A new genetic male sterile line 'GMS500' with 100% of male sterile plants was obtained, which was similar to 'XA500' in horticultural characteristics. An excellent hybridized combination was developed, which is uniform and superior to 'Ziting 11' in yield.

  12. Personality Traits and Motives for Volunteering

    OpenAIRE

    Marija Juzbasic; Tena Vukasovic Hlupic

    2015-01-01

    The aim of this study was to test the possibility of predicting volunteer motives based on five-factor model of personality in a sample of 159 volunteers from Zagreb, Osijek and Split. Data was collected using IPIP-300 personality questionnaire and Volunteer Functions Inventory. Results indicate that Croatian volunteers are agreeable, conscientious, altruistic, dutiful, and moral persons with artistic interests. Their most salient motives for volunteering are understanding and values. Hierarc...

  13. North Central Region 4-H Volunteers: Documenting Their Contributions and Volunteer Development

    Science.gov (United States)

    Nippolt, Pamela Larson; Pleskac, Sue; Schwartz, Vicki; Swanson, Doug

    2012-01-01

    Documenting volunteer contributions strengthens Extension partnerships with volunteers. A team of North Central Region 4-H volunteer specialists collaborated to conduct a study of 4-H volunteer contributions and impacts related to working with youth within the 4-H program. Over three thousand (3,332) 4-H volunteers from throughout the 12-state…

  14. Bioequivalence of paracetamol and dihydrocodeine tatrate capsules in Chinese healthy volunteers%氨酚双氢可待因胶囊在健康人体的生物等效性

    Institute of Scientific and Technical Information of China (English)

    邱相君; 王淑英; 刘涛; 袁世英; 刘心霞; 陈汇

    2011-01-01

    Objective To study the bioequivalence of paracetamol and dihydrocodeine tartrate capsules in healthy volunteers.Methods A single oral dose of tested and reference formulation were given to 20 healthy volunteers in a randomised crossover study.The concentrations of acetaminophen and dihydrocodeine in plasma were determined by HPLC, respectively.The pharmacokinetic parameters were calculated and the bioavailability and bioequivalence of acetaminophen and dihydrocodeine were evaluated by DAS program.Results After a single dose, the pharmacokinetic parameters for acetaminophen were as follows: Cmax were (9.06 ±2.05) and (9.15 ±2.50) mg· L-1; AUC0-14were (34.46 ±7.49) and (35.91 ±7.01) mg · h · L-1; AUC0-∞ were (35.66 ±7.86) and (37.24 ± 7.56) mg· h · L- 1 for tested and reference formulation, respectively.The relative bioavailability was (97.17 ± 19.09)%The pharmacokinetic parameters for dihydrocodeine were as follows:Cmax were (61.84 ±9.84) and (58.33 ±6.79) μg · L-1; AUC0-14 were (289.23 ±31.30) and (281.56 ±25.91) μg · h · L-1; AUC0-∞ were (304.83 ±32.95) and (298.45 ±29.15) μg · h · L-1 for tested and reference formulation, respectively.The relative bioavailability was ( 103.58 ± 15.09) %.Conclusion The results of the statistic analysis showed that the two formulations were bioequivalence.%目的 研究氨酚双氢可待因胶囊(解热镇痛药)在健康人体的生物等效性.方法 健康志愿者 20 名随机双交叉分别单剂量口服氨酚双氢可待因胶囊(试验制剂)和氨酚双氢可待因片(参比制剂);分别于服药后 14 h 内,多点抽取静脉血;用高效液相色谱法分别测定血浆中对乙酰氨基酚和双氢可待因的浓度;用 DAS 程序计算相对生物利用度并评价 2 种制剂生物等效性.结果 单剂量口服氨酚双氢可待因胶囊和片剂后,血浆中对乙酰氨基酚的 Cmax 分别为(9.06±2.05),(9.15±2.50)mg·L-1;AUC0-14分别为(34.46±7.49),(35.91±7.01)mg·h·L-1

  15. 厄贝沙坦氢氯噻嗪胶囊在健康人体的生物等效性%Bioequivalence of irbesartan and hydrochlorothiazide capsules in Chinese healthy volunteers

    Institute of Scientific and Technical Information of China (English)

    邱相君; 刘涛; 袁世英; 刘心霞; 陈汇

    2011-01-01

    Objective To study the bioequivalence of irbesartan and hydrochlorothiazide capsules in healthy volunteers. Methods A single o-ral dose of test and reference formulations were given to 22 healthy volunteers in a randomised crossover study. The concentrations of irbesartan and hydrochlorothiazide in plasma were determined by HPLC, respectively. The pharmacokinetic parameters were calculated and the bioavailability and bioequivalence of irbesartan and hydrochlorothiazide were evaluated by DAS program, respectively. Results After a single dose, the pharmacokinetic parameters of irbesartan for test and reference formulations were as follows; Cmax were (2.61 ±0. 62) and (2. 57 ±0.46) mg · L-1; AUC0-36 were (15. 14±3.43) and (15.39 ±3.91) mg · H · L-1; AUC0_∞ were (16. 37 ±3.42) and (16. 80 ±4. 28) mg · H · L-1, respectively. The relative bioavailability of irbesartan was (100.75 ± 19.42)%. The pharmacokinetic parameters of hydrochlorothiazide for test and reference formulations were as follows: Cmax were (162.51 ±27.55) and (168.18 ±25.71) μg · L-1; AUC0-36 were (1115.41 ±147.34) and (1144.15 ±171.62)μg · H · L-1; AUC0-∞ were (1212.68 ± 160.77) and (1252.75 ±211.27) μg · H · L-1, respectively. The relative bioavailability of hydrochlorothiazide was(98. 53 ± 13. 35)%. Conclusion The results of the statistic analysis showed that the two formulations were bioequiv-alence.%目的 研究厄贝沙坦氢氯噻嗪胶囊(抗高血压药)在健康人体的生物等效性.方法 22名健康志愿者,随机双交叉单剂量口服厄贝沙坦氢氯噻嗪胶囊(试验制剂)和厄贝沙坦氢氯噻嗪片(参比制剂),剂量为厄贝沙坦300 mg、氢氯噻嗪25 mg.分别于服药后36 h内,多点抽取静脉血,用高效液相色谱法分别测定血浆中厄贝沙坦和氢氯噻嗪的浓度.用DAS程序计算相对生物利用度,并评价2种制剂生物等效性.结果 单剂量口服厄贝沙坦氢氯噻嗪胶囊和片剂后的药代动力学

  16. More than Volunteering: Active Citizenship through Youth Volunteering

    Science.gov (United States)

    Learning and Skills Network (NJ1), 2007

    2007-01-01

    This pack aims to provide materials to help all those involved in youth volunteering and post-16 citizenship education to ensure that there are some citizenship learning outcomes from these valuable experiences. The pack has been produced by the Post-16 Citizenship Support Programme to help the integration of citizenship education into post-16…

  17. 蜜腺发达Ogura晚抽薹不结球白菜雄性不育系的鉴定%Evaluation of Late - bolting Ogura Chinese Cabbage Male Sterile Lines with Developed Nectar Gland

    Institute of Scientific and Technical Information of China (English)

    孙艳; 刘维信

    2011-01-01

    By comparing of bumble bee visiting and staying time on flowers of Ogura non - heading Chinese cabbage male sterile lines, two plants were identified and selected as they attracted more bumble bee visiting. Nectar gland size, flowering, and pod set of these two plants were further determined. The results showed that the two selected plants all had developed nectar glands, flowered and set pod normally. This finding set a well foundation for breeding out elite late -bolting Ogura male sterile lines in non -heading Chinese cabbage.%本试验以Ogura晚抽薹不结球白菜薹ms等为材料,通过观察和比较熊蜂对不同白菜品种访花次数和访花滞留时间的差异,选择出能吸引熊蜂访花且访花滞留时间长的Ogura薹ms植株.对选择出植株的蜜腺大小和开花结实特性进行了进一步鉴定,结果表明选出的薹ms株蜜腺发达,开花结实正常,为选育优良晚抽薹胞质不结球白菜雄性不育系奠定了基础.

  18. Comparative study on 3-point shot rate of Chinese male basketball team in Beijing Olympic Games%北京奥运会中国男篮3分球命中率比较研究

    Institute of Scientific and Technical Information of China (English)

    刘光鼎

    2012-01-01

    By means of literature reviews,video observation,data statistics and comparative analysis,the article systematically summarizes the 3-point shot scores of Chinese male basketball team in the Man Basketball Match of the 29th Olympic Games,such as the scores of the whole team,the guards,the forwards,and the centers.The scores are compared and analyzed with those of the opponents.The aim of article is to find out the problems that lie in the development of the Chinese male basketball team.%采用文献资料法、录像观察法、数理统计法、比较分析法等对第29届奥运会男子篮球赛中国男篮的6场比赛中,中国男篮全队整体3分球得分;后卫3分球得分;前锋3分球得分;中锋3分球得分等进行全面系统地总结,并与对手的情况进行对比与分析,希望从中找出制约我国男子篮球队发展的问题.

  19. Perceived Multiple Intelligences among Male and Female Chinese Gifted Students in Hong Kong: The Structure of the Student Multiple Intelligences Profile

    Science.gov (United States)

    Chan, David W.

    2006-01-01

    This study examined the structure of perceived multiple intelligences of 1,464 Chinese gifted students using the Student Multiple Intelligences Profile. To evaluate whether perceived multiple intelligences could be applied adequately across boys and girls, a model hypothesizing different degrees of equivalence across the two gender groups was…

  20. Interaction between oral ciprofloxacin and caffeine in normal volunteers.

    OpenAIRE

    Healy, D P; Polk, R E; Kanawati, L; Rock, D T; Mooney, M L

    1989-01-01

    The influence of multiple doses of ciprofloxacin on the disposition of caffeine and its major metabolite, paraxanthine, was investigated in healthy volunteers. Ten xanthine-free, fasting males were given 100 mg of caffeine orally 24 h before being given ciprofloxacin and again with the third dose of ciprofloxacin (750 mg administered every 12 h). Blood samples were serially collected after both doses of caffeine and after the first and last doses of ciprofloxacin. Ciprofloxacin significantly ...

  1. Immediate hematological toxicity of linezolid in healthy volunteers with different body weight: a phase I clinical trial.

    Science.gov (United States)

    Cai, Yun; Chai, Dong; Falagas, Matthew E; Vouloumanou, Evridiki K; Wang, Rui; Guo, Daihong; Bai, Nan; Liang, Beibei; Liu, Youning

    2012-04-01

    Linezolid is an important therapeutic option for infections from multi-drug resistant Gram-positive pathogens. However, prolonged linezolid treatment (>14 days) is considered to increase the risk of hematological adverse events. We aimed to evaluate the hematological safety profile of an i.v. single dose of linezolid in healthy volunteers of different body weight. We conducted a phase I clinical trial involving 20 healthy male Chinese volunteers that received an i.v. single dose of linezolid (600 mg). The study participants were assigned to two groups: low-weight (LW) group: 50 kg weight ≤55 kg and high-weight (HW) group: ≥80 kg. A significant decrease in the hemoglobin (Hb) levels and red blood cell (RBC) count was observed at the end of administration of the study drug in both groups. White blood cell (WBC) count was simultaneously decreased in the HW group. In the LW group, Hb levels and RBC count were also significantly decreased at 5, 7 and 24 h. In the HW group, both values were significantly decreased at 5 h. At 48 h all values were normal. The observed decreases were numerically higher in the LW group compared with the HW group. Yet, no statistical significance was noted. No difference was observed in the platelet count in both the groups. Our findings suggest that linezolid-associated hematological toxicity may also occur shortly after the i.v. administration of the drug in both LW and HW healthy volunteers. Early initiated continuous monitoring of hematological values and linezolid dosage adjustment for body weight are recommended.

  2. Pharmacokinetics study of Fexofenadine/Pseudoephedrine Sustained-release Tablets in healthy Chinese volunteers%非索伪麻缓释片在人体内的药动学研究

    Institute of Scientific and Technical Information of China (English)

    杨静; 宋薇; 王钊; 鹿成韬; 丁一; 周伦; 丁莉坤; 李健康; 文爱东

    2013-01-01

    Objective To study the pharmacokinetics of fexofenadine and pseudoephedrine hydrochloride in human after a single and multiple oral dose of Fexofenadine/Pseudoephedrine Sustained-release Tablets and to assess the sustain-release characteristics of pseudoephedrine hydrochloride compared with the conventional preparation of pseudoephedrine hydrochloride and Chlorphenamine Maleate Capsules .Methods An oral single dose and multiple doses of Fexofenadine/Pseudoephedrine Sustained-release Tablets were given to 12 healthy volunteers sequentially ,respectively .A two-period crossover design was used in the comparison study of the conventional formulation and the sustain-release formulation .An LC/MS/MS method was used for the determination of fexo-fenadine and pseudoephedrine hydrochloride in human plasma .Results After a single dose administration of Fexofenadine/Pseudo-ephedrine Sustained-release Tablets ,the main pharmacokinetic parameters were as follows :Cmax (133 ± 44)μg · L -1 ,tmax (2 .2 ± 1 .4) h ,AUC0-t (1 088 ± 288)μg · h · L -1 and t1/2 (9 .97 ± 2 .14) h for fexofenadine and Cmax (319 ± 47)μg · L -1 ,tmax (4 .0 ± 1 .4) h ,AUC0-t (4 046 ± 857)μg · h · L -1 and t1/2 (5 .81 ± 0 .93) h for pseudoephedrine hydrochloride .After the multiple doses admin-istration of Fexofenadine/Pseudoephedrine Sustained-release Tablets ,the main pharmacokinetic parameters were as follows :Cmax (464 ± 95)μg · L -1 ,tmax (1 .1 ± 0 .4) h ,AUC0-t (3 005 ± 425)μg · h · L -1 and t1/2 (9 .81 ± 2 .12) h for fexofenadine and Cmax (381 ± 54)μg · L -1 ,tmax (3 .1 ± 1 .0) h ,AUC0-t (4 608 ± 802)μg · h · L -1 and t1/2 (5 .78 ± 0 .47) h for pseudoephedrine hydrochlo-ride .The 90% confidence interval of AUC and Cmax of pseudoephedrine hydrochloride of the sustained-release formulation were 99 .6%-119 .3% and 77 .6%-94 .7% ,respectively .The tmax was prolonged significantly .Conclusion After administration of Fexo-fenadine/Pseudoephedrine Sustained-release Tablets

  3. Freshman year mental health symptoms and level of adaptation as predictors of Internet addiction: a retrospective nested case-control study of male Chinese college students.

    Science.gov (United States)

    Yao, Bin; Han, Wei; Zeng, Lingxia; Guo, Xiong

    2013-12-15

    A retrospective nested case-control study was designed to explore whether freshman year mental health status and level of adaptation are predictors of Internet addiction. The study cohort was 977 college students at a university in northwest China. In the first college year, the students' mental health status and adaptation level were assessed using the Chinese College Student Mental Health Scale (CCSMHS) and the Chinese College Student Adjustment Scale (CCSAS). In the following 1-3 years, 62 Internet-addicted subjects were identified using Young's 8-item diagnostic questionnaire. Controls were matched for demographic characteristics. Using logistic regression analysis, freshman year mental health status, including factors such as somatization, anxiety, depression and self-contempt, and freshman year adaptive problems were found to be causal factors and predictors of Internet addiction. Freshman with features of depression, learning maladaptation and dissatisfaction could be an important target-intervention population for reducing Internet addiction.

  4. LC-MS/MS法测定我国健康受试者48h内伊伐布雷定和去甲伊伐布雷定的尿排泄率%LC-MS/MS determination of 48-h urine excretion rates of ivabradine and N-desmethylivabradine in healthy Chinese volunteers

    Institute of Scientific and Technical Information of China (English)

    鹿成韬; 陈敏纯; 贾艳艳; 宋颖; 杨静; 丁莉坤; 李雪晴; 周伦; 文爱东

    2012-01-01

    Objective: To determine urine excretion properties of ivabradine and N-desmethylivabradine in healthy Chinese volunteers after single and multiple doses of ivabradine hydrochloride tablets.Methods: Ten volunteers were orally administered with a single and multiple 5 mg doses of ivabradine hydrochloride tablets, respectively.Urine samples were collected pre-dose and at the different post-dose intervals during 48 h.The volume of u-rine was recorded.The urine concentrations of ivabradine and N-desmethylivabradine were detected by a LC-MS/ MS method, and the urine excretion rate was calculated.Results: The mean cumulative urinary excretion rates of ivabradine and N-desmethylivabradine up to 48 h were (14.03 ±4.65)% and (2.02 ± 0.44 ) % after single doses, and (22.63 ±4.01)% and (3.60 ± 1.12)% after multiple doses.Conclusion: The LC-MS/MS method is simple, accurate, sensitive and specific for determination of ivabradine and its active metabolite N-desniethylivabra-dine in human urine.After taking orally, there was less than 30% urine excretion of ivabradine and N-desmethyliv-abradine in healthy volunteers.%目的:研究健康受试者单次和多次口服盐酸伊伐布雷定片后,伊伐布雷定和其活性代谢产物去甲伊伐布雷定的尿排泄特征.方法:10例健康受试者单次和多次口服盐酸伊伐布雷定片5 mg.在服药前以及服药后48 h内分不同时间段采集尿样,记录尿液体积,用LC-MS/MS检测尿液中伊伐布雷定和去甲伊伐布雷定的浓度,计算伊伐布雷定和去甲伊伐布雷定的平均累计排泄率.结果:受试者单次口服盐酸伊伐布雷定片后,尿液中伊伐布雷定48 h的平均累积排泄率为(14.03±4.65)%;去甲伊伐雷定的平均累积排泄率为(2.02±0.44)%.受试者多次口服盐酸伊伐布雷定片,尿液中伊伐布雷定48 h的平均累积排泄率为(22.63±4.01)%;去甲伊伐雷定的平均累积排泄率为(3.60±1.12)%.结论:本研究所建立的LC-MS/MS方

  5. 定向转育卵圆生态型大白菜雄性不育系的研究%Directional Breeding of An Oval-ecotype Male Sterile Line of Chinese Cabbage(Brassica campestris L. ssp. pekinensis)

    Institute of Scientific and Technical Information of China (English)

    谭翀; 郭瑛琪; 岳艳玲

    2014-01-01

    [目的]探究大白菜定向转育卵圆生态型雄性不育系的方法。[方法]以大白菜核不育"复等位基因遗传假说"为理论依据,以甲型两用系‘AB12’为不育供体品系,以卵圆生态型可育品系‘06048’为待转育品系,采用杂交、回交、兄妹交和测交的方法,按照定向转育方案将核不育基因定向转育。[结果]各世代育性分离比率与理论相一致,成功育成了一种不育株率100%的具有‘06048’园艺性状的新核不育系,实现了核不育基因和园艺特性的同时转育。[结论]该研究成果验证此定向转育方案是可行的,进一步为基因型为 msms的其他园艺性状的大白菜定向转育提供理论基础,也可以推广应用到整个芸薹属其它经济作物中,极大的拓宽了优良核不育基因的实际应用范围。%Objective] The study aimed to explore the method for directional breeding of a male-sterile line in oval-ecotype Chinese cabbage. [Method] Based on "Multiple Al ele Hypothesis of Genic Male Sterile Chinese Cabbage", an inbred line ‘06048’ of oval ecotype was used as the receptor, and male fertile plant of ‘AB12’ was used as the donor line. Crossing, backcross, selfing, testcross and sibling were ap-plied to transfer the multiple al eles under the directional genetic model. [Result] Segregation ratio of every generation was consistent with theoretical value. A new male sterile line with 100% male sterility and ‘06048’ horticultural traits was ob-tained successful y, which accomplished the transfer of male sterile multiple al ele and horticultural characters of receptor line at the same time. [Conclusion] The re-search verifies that the model of directional transfer is feasible, provides a theoreti-cal basis for the directional transfer of Chinese cabbage with other horticultural traits whose genotype is msms. The model can also be applied to other Brassica crops, to generate genetic male sterile lines

  6. Spermatogenous Analysis of Chinese Giant Salamander Males Which Are Induced to Spawn%人工催产后雄性中国大鲵产精状况分析

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

      为探索中国大鲵的繁殖特点,人工催产20尾雄性亲鲵,催产率达90%,但产活力精子雄鲵的比例只有20%,表明大鲵雄性不育的比例高达80%;对产出精子研究显示,大鲵活力精子在不同硬度水体中的存活时间不同。适应硬度范围内,大鲵活力精子存活时间随水体硬度升高而缩短,当水体硬度为0.41 mmol/L 时,大鲵精子最长存活161 s ;硬度为3.14 mmol/L 时,大鲵精子最长存活65 s ,开展大鲵人工繁殖时,应关注雄性不育及水体硬度对受精率的影响。%Twenty Chinese giant salamander A ndrias davidianus males were artificially induced to spawn , with spawning success of 90% .However ,only 20% of the male spawners were found to release the vital sperm ,indicates that 80% of the male spawners were of sterile males . The vitality test showed that survival period of the sperm motility was different in the water with different hardness . The survival period of the sperm motility was found to be decreased with increase in water hardness within water hardness of 0 .17 ~ 2 .136 mmol/L .The salamander sperm showed the longest life span (161 s) at water hardness of 0 .41 mmol/L .On the contrary ,the minimal survival period (65 .4 s )was observed in the sperm at water hardness in the 3 .14 mmol/L .So we should pay attention to the problem of male sterile and effects of water hardness on fertility when we carry out artificial reproduction of Chinese giant salamander .

  7. 大白菜隐性细胞核雄性不育恢复基因BrMsf3的标记%SRAP Marker Analysis of Recessive Genic Male Sterile Restoring Gene in Chinese Cabbage

    Institute of Scientific and Technical Information of China (English)

    张慧; 张淑江; 李菲; 章时蕃; 孙日飞

    2011-01-01

    对一大白菜隐性细胞核雄性不育系454AB的恢复基因BrMsf3进行了SRAP标记,构建包含320个单株的分离群体,筛选SRAP标记1 128个,筛选出与恢复基因BrMsf3连锁的2个标记BMe10SA4和M52K2,与恢复基因BrMsf3的遗传距离为4.35 cM和7.74 cM.%Genic male sterility lines were widely used in F1 seed production in Chinese cabbage ( Brassica rapa L. ssp. pekinensis ) . A recessive genic male sterile line 454AB which contained 320 individuals was constructed for this study. SRAP techniques and bulked segregant analysis ( BSA ) were used to screen markers linked to the RGMS restoring gene. Among the 1 128 primer combinations, only BMel0SA4 and M52K2 showed polymorphism between bulks of male sterile and fertile. The genic distances between restoring gene with BMe10SA4 and M52K2 were 4.35 cM and 7.74 cM, respectively.

  8. Towards trusted volunteer grid environments

    CERN Document Server

    Khemakhem, Maher; University, Sousse; Tunisia,; University, Manouba; Tunisia),; 10.5121/ijcnc.2010.2207

    2010-01-01

    Intensive experiences show and confirm that grid environments can be considered as the most promising way to solve several kinds of problems relating either to cooperative work especially where involved collaborators are dispersed geographically or to some very greedy applications which require enough power of computing or/and storage. Such environments can be classified into two categories; first, dedicated grids where the federated computers are solely devoted to a specific work through its end. Second, Volunteer grids where federated computers are not completely devoted to a specific work but instead they can be randomly and intermittently used, at the same time, for any other purpose or they can be connected or disconnected at will by their owners without any prior notification. Each category of grids includes surely several advantages and disadvantages; nevertheless, we think that volunteer grids are very promising and more convenient especially to build a general multipurpose distributed scalable enviro...

  9. Comparison of Methods for Transferring Genetic Male Sterile Lines of Orange Head Chinese Cabbage with Anti-clubroot%桔红心大白菜抗根肿病不育系转育方法比较

    Institute of Scientific and Technical Information of China (English)

    耿新翠; 沈向群; 李林; 李茜; 陈永浩

    2012-01-01

    以普通心抗根肿病甲型“两用系”和桔红心自交系LH为试材,通过杂交、回交和系内交等方法研究了桔红心与普通心的遗传关系、桔红心自交系抗性和育性的基因型.试验结果表明:桔红心对普通心表现为一对隐性基因控制的简单遗传,桔红心自交系的抗性和育性基因型分别为rr和msms;提出了桔红心大白菜抗根肿病雄性不育系的两种转育模式,其中系内交模式比回交模式提前一代得到新的不育系;在第二代筛选桔红心性状时,对子叶法、球心色法和花色法三种方法进行了比较,子叶法不但在幼苗期就可以筛选到桔红心性状,而且抗性调查和育性鉴定的群体最小,是三种方法中最理想的.%Taking the genetic male sterile AB lines (type 1) of yellow head Chinese cabbage with anti -clubroot and orange head Chinese cabbage lines (LH) as the test materials, the genetic relations between the head colors of orange and yellow and the genotypes of clubroot - resistance and fertility of orange head lines were studied through cross, backcross and sibling mate. The experimental results indecated clearly that orange to yellow was controlled by a pair of recessive genes, and rr and msms were the anti-cluhroot genotype and fertile genotype of LH. In the light of these, this study proposed two models of transferring genetic male sterile lines of orange head Chinese cabbage with anti-clubroot, among which model ( 2) could get genetic male sterile lines in the fourth generation, but model ( 1) in the fifth generation. Although orange plants will be sifled out in the second generation using cotyledon method, head color method or flower color method, cotyledon method will be the best one, for in this way orange plants can be screened in the seedling stage, and survey groups of resistance and fertility will be smaller than other methods.

  10. A psychophysical evaluation of NIOSH Lifting Equation in a Chinese young male population: a pilot study%最大可接受提举重量的研究

    Institute of Scientific and Technical Information of China (English)

    肖国兵; 梁友信

    2008-01-01

    Objective To determine the maximum acceptable weight of lift (MAWL) in a Chinese young male population, and examine whether the revised weight limit recommended by the US. National Institute for Occupational Safety and Health can be used for Chinese workers. Methods Eleven young male college students participated in the experiment. The psychophysical approach was used to determine the MAWL with the different frequencies of lift, the heart rate and the self-evaluation. The weight was lifted from the floor to the worktable (760mm). The results were compared with the recommended weight limit (RWL) and the MAWL by Snook. Results The MAWL of young male was 34.1kg while the MAWL with frequency of 1, 4 and 8/min was 17.4, 14.7 and 12.2kg respectively. The overall MAWL were lower than RWL of NIOSH and the results of Snook. Conclusion The NIOSH 1991 equation such as load constant and frequency multiple should be revised when the NIOSH limits is used in Chinese population.%目的 探讨中国青年男性的最大可接受提举重量,验证美国职业安全卫生研究所(NIOSH)提出的提举重量限值能否在中国应用.方法 11名年轻男性大学生参加试验.通过心理物理学方法,获得不同提举频率下的最大可接受提举重量、心率和用力自我感受,提举高度为从地面到工作台(760mm).结果 与NIOSH建议值和美国利宝集团研究结果进行比较.结果 年轻男性的一次最大可接受提举重量为34.1kg,而1、4、8次/min的最大可接受提举重量则分别为17.4、14.7、12.2 kg.结果 明显低于NIOSH的推荐限值.结论 应用NIOSH提举公式时应作调整,如降低提举重量常数和提举频率系数等.

  11. 76 FR 20215 - National Volunteer Week, 2011

    Science.gov (United States)

    2011-04-12

    ... real and lasting impact on the lives of millions of women and men across the globe. Last year, nearly... they see a need. During National Volunteer Week, we celebrate the profound impact of volunteers and... week by volunteering in service projects across our country and pledging to make service a part...

  12. The Contribution of Social Resources To Volunteering.

    Science.gov (United States)

    Wilson, John; Musick, Marc

    1998-01-01

    Outlines a theory of how social capital contributes to volunteering, hypothesizing that social capital has a stronger effect on volunteering among people with more human capital and socioeconomic status. Specifies a test (of the effects) of social capital on volunteering and discusses the findings (of the test) in detail. (CMK)

  13. Student Volunteering in English Higher Education

    Science.gov (United States)

    Holdsworth, Clare; Quinn, Jocey

    2010-01-01

    Volunteering in English higher education has come under political scrutiny recently, with strong cross-party support for schemes to promote undergraduate volunteering in particular. Recent targeted initiatives and proposals have sought to strengthen both the role of volunteering in higher education and synergies between higher education and…

  14. Nurses' perceptions of hospice palliative care volunteers.

    Science.gov (United States)

    Claxton-Oldfield, Stephen; Hastings, Emily; Claxton-Oldfield, Jane

    2008-01-01

    A total of 50 nurses (hospital and home care) responded to a survey designed to measure: (1) their attitudes toward, and knowledge of, hospice palliative care volunteers; (2) the types of tasks they felt it was appropriate for volunteers to perform; and (3) how valuable they felt different members of the hospice palliative care team are. In addition, they were asked to respond to some open-ended questions (eg, "Do you feel that it is appropriate for hospice palliative care volunteers to know patient medical information?"). The nurses' responses to the "Attitude/Knowledge" part of the survey revealed that they generally held positive attitudes toward volunteers. The majority of the nurses felt that it was appropriate for volunteers to perform most of the tasks listed, except for hands-on patient care. Nurses rated the value of nurses, family members, doctors, and pharmacists significantly higher than volunteers. Fifty-three percent of the nurses felt that volunteers should know patient medical information, and 77% thought that volunteers should have the opportunity to provide input regarding patient care. Also, 75% of the nurses felt that volunteers made their jobs easier, and 56% felt that volunteers should be included in team meetings. When asked to list the topics covered in a hospice palliative care volunteer training program, 73% of the nurses indicated that they were not sure or did not know what topics were covered, indicating a lack of knowledge regarding volunteer training.

  15. Engaged anthropology and corporate volunteering

    Directory of Open Access Journals (Sweden)

    Natália Blahová

    2015-12-01

    Full Text Available The aim of this paper is to present engaged anthropology and its methodological tools with a specific perspective of the research field and the position of the researcher with regard to research subjects. The study focuses on corporate volunteering as one of the forms of collaboration between the non-profit and the private sectors seeking solutions to social problems and community development. Volunteering projects contribute to the interlinking of the knowledge, skills, experience and resources of corporate employees and the representatives of the non-profit or the public sector. It is a part of the philanthropic strategy of companies which are willing to present themselves as entities responsible towards the environment in which they run their business, and towards their employees, partners and customers. Engaged anthropology can bring, through its methodological tools, a new perspective of corporate volunteering. Community-based participatory research on the process of knowledge creation includes all partners on an equal basis and identifies their unique contribution to problem solution and community development.

  16. The Understanding of Volunteer Tourism

    OpenAIRE

    Arbuzova, K. I.; Арбузова, К. И.

    2012-01-01

    The article considers the notion of volunteer tourism. The author identifies the main meaning of the term, considers the main problems of volunteer tourism and identifies relevant of volunteer tourism. В статье рассматривается понятие волонтерского туризма. Автор статьи определяет основные значения термина, рассматривает основные проблемы волонтерского туризма и определяет значимость волонтерского туризма....

  17. Bioequivalence assessment of amoxicillin by limited sampling strategy in Chinese healthy volunteers%LSS法估算中国健康志愿者口服阿莫西林的生物等效性

    Institute of Scientific and Technical Information of China (English)

    陈丽芳; 焦建杰; 张才丽; 娄建石

    2012-01-01

    Objective To develop limited sampling strategy ( LSS) for estimating bioequivalence of amoxicillin. Methods Twenty male healthy subjects were enrolled in this bioequivalence study. All subjects were divided into two groups randomly and administered orally reference and test formulation of 500 mg amoxicillin. The blood concentrations of amoxicillin were determined by the validated HPLC method. A multiple linear regression analysis was developed for estimating Cmax and AUC0_t using the amoxicillin concentration of the reference formulation to develop LSS models. The LSS models were internally validated by the Jackknife meth od. The models were also externally validated by bioequivalence assessment of the test amoxicillin formulation based on LSS derived Cmax and AUC0-t values, The results were compared with those obtained using traditional method. Results The results indicate: several models for these parameters estimation met the predefined criteria. Validation tests indicated that most informative sampling points C1, C3 and C1 ,C2,C4 provided accurate estimations of the parameters AUC0-1, ( prediction error < 1% , absolute percentage < 10% ) ,And C1 ,C1.5 and C1.5 ,C2,C6 provided accurate estimations of the parameters Cmax ( prediction error < 2% , absolute percentage < 9%) . The combination of C1.5, C2, C6 might be chosen as sampling hours for predicting AUC0-t, and Cmax according to requirement. It is according with classical assessment. Conclusion The bioequivalence assessment results showed that LSS models provided correct assessment of bio equivalence between two amoxicillin preparations. The method is accurant and can be considered desirable for amoxicil lin bioequivalence study.%目的 用有限采样法(LSS)估算口服阿莫西林的生物等效性.方法 20名健康志愿者口服阿莫西林参比药物和受试药物500 mg后采集若干时间点血浆样品,用高效液相色谱法测定阿莫西林血药浓度,用经典方法计算药代动力学参

  18. Research on the Somatotype Features of Chinese Elite Male Taekwondo Athletes%中国优秀男子跆拳道运动员体型特征研究

    Institute of Scientific and Technical Information of China (English)

    高炳宏; 赵秋蓉; 刘德皓

    2001-01-01

    30 elite male athletes who won the first four places at different body weight at the 1997 Chinese national taekwondo championship were taken as subjects for somatotype study. The aim is to better understand their somatotype features and provide basis for reasonable athlete selection and scientific training. The results showed that the somatotype of Chinese male taekwondo athletes was featured by well-proportioned stature, well-developed muscles and skeletons, and low subcutaneous fat. With the rising of body weight, the somatotype of male athletes transforms from derio-mesomorph to mesomorph. Compared with athletes of other sports in and out of China, taekwondo male athletes' somatotype shows some remarkable characteristics.%本文对1997全国跆拳道锦标赛男子各级别前4名运动员(共30名)的体型进行测定研究,旨在了解运动员体型的现状、特点和某些规律性特征,为科学选材,合理选择级别,提出客观依据。结果如下:我国优秀男子跆拳道运动员的体型具有一定的规律性特征,即体型分布相对较为集中,其体型特征为:体型匀称,肌肉、骨骼较为发达,体脂%低,身材较高大,其体型3因子均值为2.12~4.41~3.18;随级别升高,体型由外胚叶性—中胚叶型向中胚叶型转变;与国内外其它项目比较,体型有自身特点:3因子均值不大,差值较小,体型匀称。

  19. Effects of gibberellin A4/7, 6-benzylaminopurine and chlormequat chloride on the number of male and female strobili and immature cones in Chinese Pine (Pinus tabuliformis) with foliar sprays

    Institute of Scientific and Technical Information of China (English)

    ZHAO Peng; FAN Jun-feng; ZHANG Shuo-xin; HUANG Zhong-lian; YANG Pei-hua; MA Zhen-hua; Keith E. Woeste

    2011-01-01

    Three kinds of plant growth regulators, gibberellinA (GA),6-benzylaminopurine (BA), and chlormequat chloride (CCC), wereevaluated for their ability to promote strobilus and cone production in aChinese pine (Pinus tabuliformis Carr.) clonal seed orchard. Treatments(0, 250, 500, or 1000 mg-L) were applied during three periods (June-July, July-August and August-September) in 2005. Of the three plantgrowth regulators, GA was the best for promoting flower and coneproduction. Trees sprayed with GA(500 mg·L) from June to Septem-ber had significantly more female strobili and immature cones than con-trols and other treatments (p≤0.0001). The best time to apply GA was inJune. BA at 500 mg.L significantly increased female flower and imma-ture cone production, compared to other treatments and controls(p≤0.0001), while promotion of male strobili was unchanged. Chlorme-quat chloride at 1000 mg.L significantly increased the number of malestrobili, compared to the other treatments (P≤0.0001). Spraying CCC at500 mg.L significantly increased the number of female strobili, com-pared to controls (p0.05). These results are important for improving seed productionand seed orchard management of Chinese pine.

  20. Volunteer Tourism in Japan: Its Potential in Transforming “Non-volunteers” to Volunteers

    OpenAIRE

    Yoda, Mami

    2010-01-01

    This paper explores the potential of volunteer tourism to transform “non-volunteers” to volunteers in Japan. Volunteer tourism is defined as travel to a location outside the immediate vicinity of daily life in order to engage in organized volunteer activities. In-depth interviews and a survey were conducted to the employees of Haagen-Dazs Japan, Inc., who participated to volunteer tours to the Kiritappu Wetland Trust in Hokkaido. The study closely examines the motivations of the participants...

  1. Study on breeding and utilization of genetic male sterile line in dwarf Chinese cabbage%矮脚黄白菜核基因雄性不育系的创制与利用

    Institute of Scientific and Technical Information of China (English)

    王昊; 杨宁; 冯辉

    2011-01-01

    A directional transfer program was designed by using multiple allele inherited genetic male-sterile line AB01 and its temporary maintainer line B01 as source of male sterility, and recurrent backcrossing was employed to transfer botanical traits, while the genotype was identified through test cross. Following the procedure, the male sterile gene was successfully transferred to the target parent "Y", the inbred line of Jinguan in dwarf Chinese cabbage. A new male sterile line GMS401, which is similar to Y on botanical traits with 100% male sterility and 100% male sterile plants, was bred. The results showed that GMS401 as the female parent, the hybridized combinations GMS401×D1 and GMS401× D2 were finally obtained and they were excellent in horticultural characters and uniformity. In addition, the yield of the combinations was apparently higher than that of CK.%以复等位基因遗传的早熟大白菜雄性不育“两用系”AB01和“临时保持系”B01为试材,设计定向转育方案,采用连续回交转育性状的同时,测交筛选基因型的方法,向源自金冠的矮脚黄白菜自交系Y中转育雄性不育基因,育成了不育株率和不育度均为100%、园艺学性状与自交系Y相近的矮脚黄白菜核基因雄性不育系GMS401.结果表明,用GMS401试配的杂交组合(GMS401×D1)和(GMS401×D2)整齐度高,园艺学性状优异,产量显著高于对照品种南京矮脚黄和抗病矮脚黄.

  2. The CFTR M470V, Intron 8 Poly-T, and 8 TG-Repeats Detection in Chinese Males with Congenital Bilateral Absence of the Vas Deferens

    Directory of Open Access Journals (Sweden)

    Qiang Du

    2014-01-01

    Full Text Available Purpose. To evaluate the significance of molecular detection of cystic fibrosis transmembrane conductance regulator (CFTR M470V, intron 8 poly-T, and intron 8 TG-repeats in congenital bilateral absence of the vas deferens (CBAVD. Methods. Eighty-nine male patients with CBAVD and 103 healthy males were included in this study. Polymerase chain reaction was performed to amplify the polymorphic regions using primers from conserved regions. M470V was genotyped using real-time PCR by cycling probe. The exon 9 DNA sequence was determined using an automated sequencer. TG-repeats and poly-T were identified by direct sequencing analysis. Results. The 5T allele distribution was 0.32, 0.66 for 7T, and 0.02 for 9T in CBAVD males, respectively. In contrast, the 5T allele distribution was 0.03, 0.96 for 7T, and 0.01 for 9T in healthy control. Study of the polymorphisms of the upstream of exon 9 revealed a higher frequency of 5T allele in the CBAVD males. All cases with TG13T5 haplotype and TG12T5 homozygous led to CBAVD. The CFTR TG12T5-V470 variant haplotype was associated with CBAVD. Conclusion. The 5T allele of intron 8 of CFTR has clinically significant association with CBAVD. TG13T5 and TG12T5 homozygously led to CBAVD, and TG12T5-V470 may also lead to CBAVD.

  3. A genome-wide association and gene-environment interaction study for serum triglycerides levels in a healthy Chinese male population.

    Science.gov (United States)

    Tan, Aihua; Sun, Jielin; Xia, Ning; Qin, Xue; Hu, Yanling; Zhang, Shijun; Tao, Sha; Gao, Yong; Yang, Xiaobo; Zhang, Haiying; Kim, Seong-Tae; Peng, Tao; Lin, Xiaoling; Li, Li; Mo, Linjian; Liang, Zhengjia; Shi, Deyi; Huang, Zhang; Huang, Xianghua; Liu, Ming; Ding, Qiang; Trent, Jeffrey M; Zheng, S Lilly; Mo, Zengnan; Xu, Jianfeng

    2012-04-01

    Triglyceride (TG) is a complex phenotype influenced by both genetic and environmental factors. Recent genome-wide association studies (GWAS) have identified genes or loci affecting lipid levels; however, such studies in Chinese populations are limited. A two-stage GWAS were conducted to identify genetic variants that were associated with TG in a Chinese population of 3495 men. Gene-environment interactions on serum TG levels were further investigated for the seven single nucleotide polymorphisms (SNPs) that were studied in both stages. Two previously reported SNPs (rs651821 in APOA5, rs328 in LPL) were replicated in the second stage, and the combined P-values were 9.19 × 10(-26) and 1.41 × 10(-9) for rs651821 and rs328, respectively. More importantly, a significant interaction between aldehyde dehydrogenase 2 (ALDH2) rs671 and alcohol consumption on serum TG levels were observed (P = 3.34 × 10(-5)). Rs671 was significantly associated with serum TG levels in drinkers (P = 1.90 × 10(-10)), while no association was observed in non-drinkers (P > 0.05). For drinkers, men carrying the AA/AG genotype have significantly lower serum TG levels, compared with men carrying the GG genotype. For men with the GG genotype, the serum TG levels increased with the quantity of alcohol intake (P = 1.28 × 10(-8) for trend test). We identified a novel, significant interaction effect between alcohol consumption and the ALDH2 rs671 polymorphism on TG levels, which suggests that the effect of alcohol intake on TG occurs in a two-faceted manner. Just one drink can increase TG level in susceptible individuals who carry the GG genotype, while individuals carrying AA/AG genotypes may actually benefit from moderate drinking.

  4. 中国男子跳远运动员起跳不同时相的运动学参数%Study on different kinematic parameters during the take-off phase of Chinese male broad jump athletes

    Institute of Scientific and Technical Information of China (English)

    马俊明; 周巧玲; 朱咏贤

    2003-01-01

    目的中国优秀男子跳远运动员起跳中不同时相速度变化特征的研究 ,对提高跳远成绩提供理论价值.方法采用现场定点高速摄影、影片分析以及数理统计等方法,通过对 8名优秀男子跳远运动员 A, B两组起跳阶段不同时相身体重心水平速度和垂直速度的变化与着板角、起跳缓冲和蹬伸阶段膝角变化的比较分析.结果成绩较好时,缓冲阶段身体重心水平速度的减小和垂直速度的增加相对较大;蹬伸阶段身体重心水平速度略有回升、垂直速度保持增加的态势,而且,离板瞬间身体重心水平速度和垂直速度都呈现出相对较大的趋势.结论中国优秀男子跳远运动员起跳缓冲阶段身体重心水平速度减小和垂直速度增加之间存在着密切关系.%Aim To study the velocity variations of take-off phase of Chinese male elite broad jump athletes so as to lay a theoretical basis for the improvement of broad jump results.Methods High-speed camera photography and method of film analysis were used to record and analyze the jumping results of 7 male elite Chinese broad jump athletes. The optimal results of these 8 athletes were included in group A,and the worst results in group B.The variations of the body center gravity horizontal velocity and vertical velocity, and the variations of the landing board angle of the jumping foot, buffer and knee angle during the taking off phase were compared and analyzed between A and B groups.Results The decrease of the horizontal velocity and the increase of the vertical velocity were more remarkable in the group A than in the group B during the buffer phase.The Chinese male elite long jumpers tended to incline to a small landing angle when the taking-off foot touched the board coordinated with obvious knee angle variations during the buffer and taking-off phases The horizontal velocity and vertical velocity of the athletes' body center gravity inclined to the tendency of

  5. 20 CFR 10.730 - What are the conditions of coverage for Peace Corps volunteers and volunteer leaders injured...

    Science.gov (United States)

    2010-04-01

    ... Corps volunteers and volunteer leaders injured while serving outside the United States? 10.730 Section... Corps volunteers and volunteer leaders injured while serving outside the United States? (a) Any injury sustained by a volunteer or volunteer leader while he or she is located abroad shall be presumed to...

  6. Effect of CYP2C19 genetic polymorphism on pharmacokinetic characterstics and 5-hydroxyl metabolic pathway of lansoprazole in Chinese volunteers%CYP2C19基因多态性对中国人体内兰索拉唑药代动力学及其5-羟基代谢通路的影响

    Institute of Scientific and Technical Information of China (English)

    严非; 夏春华; 熊玉卿

    2011-01-01

    AIM: To investigate the effect of CYP2C19 polymorphism on pharmacokinetic characteristics and 5-hydroxyl metabolic pathway of lansoprazole in Chinese subjects. METH-ODS: Twelve healthy subjects were typed by u-sing RFLP-PCR method. After intravenous drip 30 mg lansoprazole, the plasma concentrations of lansoprazole in subjects were determined byLC-MS method. The pharmacokinetic parameters of lansoprazole and AUClpz/AUC5-Ohlpz were calculated and compared between different groups. RESULTS-. After all the subjects were given 30 mg lansoprazole, it found that the AUCo-,, AUCo-(x), CLz, ( AUCLpz/ AUC5-oh)0-t, and (AUCLpZ/AUC5-oh)0-∞ of the mutant types were equivalent to 2.381, 2.572, 0. 428, 3. 602 and 4. 083-fold as those of the wild types, respectively. CONCLUSION: The CYP2C19 genetic polymorphism, which has significant influence on the pharmacokinetic characteristics of the lansoprazole in Chinese volun-teers (P<0. 05), has very significant influence on the 5-hydroxyl metabolic pathway of the lansoprazole (P<0. 01). The result suggests that CYP2C19 genetic polymorphism is one of the important factors leading to individual concentration differences of the lansoprazole and has a better relevance with the 5-hydroxyl metabolic pathway.%目的:研究CYP2C19基因多态性对中国人体内兰索拉唑药代动力学及其5-羟基代谢通路的影响.方法:采用RFLP-PCR方法对12名健康受试者进行CYP2C19基因多态性检测,并采用液相色谱-质谱法(LC-MS)检测兰索拉唑体内血药浓度并计算相关的药代动力学参数,比较不同基因型受试者之间主要药代动力学参数以及AUCLpz/AUC5-oH LPZ 比 值(AUGansoprazole/AUC5-hydroxylansoprazole,此参数用以评价5-羟基代谢的标准)的差异.结果:12名健康受试者在给予30 mg兰索拉唑后,发现突变型个体AUC0-t、AUC0-∞、CLz、(AUCLPZ/AUC5-OHLPZ)0-t、(AUCLPZ/AUC5-OH LPZ)0-.∞分别相当于野生型个体的2.381、2.572、0.428、3.602、4.083

  7. Post-Event Volunteering Legacy: Did the London 2012 Games Induce a Sustainable Volunteer Engagement?

    Directory of Open Access Journals (Sweden)

    Niki Koutrou

    2016-11-01

    Full Text Available The hosting of the London 2012 Olympic Games was seen as an opportunity to harness the enthusiasm of the 70,000 volunteers involved and to provide a post-event volunteer legacy. A total of 77 individuals who had acted as volunteers in London 2012 were contacted approximately four years after the Games and agreed to complete a web-based open-ended survey. The participants were asked to indicate their level of current volunteering engagement and whether volunteering at the Games had an impact on their current volunteering levels. The study found that the London Olympics were the first volunteer experience for most of the volunteers who completed the survey, with the main motivation to volunteer being anything related to the Olympic Games. Just over half of the respondents are currently volunteering. Lack of time is shown to be the main barrier towards further volunteering commitment. Only half of respondents had been contacted by a volunteering scheme after London 2012. The implications of the findings for a potential volunteering legacy are then explored.

  8. The Effect of Volunteer Work on Employability

    DEFF Research Database (Denmark)

    Petrovski, Erik; Dencker-Larsen, Sofie; Holm, Anders

    In addition to benefiting others, volunteer work is argued to supply volunteers themselves with skills, reputation, and social connections that increase overall employability. We test this hypothesized link between volunteer work and employability with a high-quality 2012 Danish survey sample of 1......,796 individuals of working age. The survey data is linked to administrative registers with individual level data on unemployment. A combination of detailed controls, lagged dependent variables, and instrumental variable regression is used in order to determine cause and effect. Our findings show that volunteers...

  9. Pain perception in healthy volunteers

    DEFF Research Database (Denmark)

    Janum, Susanne; Nielsen, Signe T; Werner, Mads U;

    2016-01-01

    We aimed to study the relationship between pain perception and cytokine release during systemic inflammation. We present a randomized crossover trial in healthy volunteers (n = 17) in 37 individual trials. Systemic inflammation was induced by an i.v. bolus of Escherichia coli LPS (2 ng/kg) on two...... separate trial days, with or without a nicotine patch applied 10 h previously. Pain perception at baseline, and 2 and 6 h after LPS was assessed by pressure algometry and tonic heat stimulation at an increasing temperature (45-48℃) during both trials. Compared with baseline, pain pressure threshold...... was reduced 2 and 6 h after LPS, while heat pain perception was accentuated at all testing temperatures after 2 but not 6 h. The magnitude of changes in pain perception did not correlate to cytokine release. No effect of transdermal nicotine or training status was observed. In conclusion, LPS administration...

  10. The Awareness of Gender Care in Chinese Male Magazines%中国男性杂志中的性别关怀意识

    Institute of Scientific and Technical Information of China (English)

    陈宁

    2012-01-01

    近年来,以男性为明确服务受众的男性杂志正面临着前所未有的商业和文化机遇。在性别观照的广度和深度上此类杂志表现出快速生长期特有的两重性。杂志突破了传统文化对两性特质的规约,多样的生活方式和审美取向得到了尊重和肯定,充满个性色彩的男性媒介形象日益丰富;但是,性别窠臼仍表现出强大的现实干预力量:夸大男性的性能力、贬低女性的职业能力并将之物质化、迷恋暴力细节等现象普遍存在,模式化的性别形象塑造正成为男性杂志创新性发展的瓶颈。%In recent years, male magazine, whose audience is specifically men, is facing unprecedented economic and cul- tural opportunities in rapid growth period. This type of magazines shows particular duality in extent and depth in the growth period in the aspect of gender observation. The magazines break the stipulations on men in traditional culture. Living methods and aesthetic appreciation in diversity get respect and affirmation. The male media images full of individuality become more and more colorful. However, the set pattern of sex displays powerful intervention in reality, paying special attention to men potency and womenprofessional capacity and materializes it, and being infatuated with violent details. The stereotype shaping of men proves to be the bottleneck in the innovation development of male magazines.

  11. Motivations and Benefits of Student Volunteering: Comparing Regular, Occasional, and Non-Volunteers in Five Countries

    Directory of Open Access Journals (Sweden)

    Karen Smith

    2010-01-01

    Full Text Available Programmes targeting student volunteering and service learning are part of encouraging civic behaviour amongst young people. This article reports on a large scale international survey comparing volunteering amongst tertiary students at universities in Australia, Canada, New Zealand, the United Kingdom, and the United States of America. The data revealed high rates of student volunteering and the popularity of occasional or episodic volunteering. There were strong commonalities in student volunteering behaviour, motivations and benefits across the five Western predominately English-speaking countries. Altruism and self-orientated career motivations and benefits were most important to students; however volunteering and non-volunteering students differed in the relative value they attached to volunteering for CV-enhancement and social factors.

  12. The Analysis of Chinese Excellent Male Weightlifting Athletes' Action%我国优秀男子举重运动员动作技术分析

    Institute of Scientific and Technical Information of China (English)

    陈玉霞; 孙明运

    2012-01-01

    利用高速摄像系统进行同步动作拍摄,运用生物力学的方法,对我国优秀男子举重运动员的关节点的坐标、速度、相关角度、位移数据进行解析和处理,并和国际优秀男选手技术进行比较,找到差距,提出问题,供教练员、运动员改进技术参考。结果发现:该队员人杠距为7.931cm,超出了查阅文献得到的优秀举重运动员杠铃与队员距离在4-7 cm之间的范围,发力时间比其他优秀队员发力时间短;发力后使杠铃获得上升的最大速度低于其他优秀运动员。%In virtue of screening in three - dimensional high - speed way, by means of sports biomechanical, this study test analy- ses the coordinates of joint points, speed, related angles, and the displacement data of excellent male weightlifting athletes, tries to find the difference between the international best male athletes, and provides technical reference for coaches. The results show that: the distance is 7. 931 cm between the body and the bar of barbell, beyond the 4 - 7cm range of the distance of excellent lifter which we find in literature, and there is a shorter force time of this player than other excellent lifters ; moreover, the maximum in- creasing rate after the force time is lower than other elite athletes.

  13. Study on the Effects of Different Chinese Medical Compounds on Male Kayak Athletes%复方中药调节男子皮艇运动员身体机能状态的研究

    Institute of Scientific and Technical Information of China (English)

    屈金亭

    2011-01-01

    目的:探讨复方中药对男子皮艇运动员冬训大负荷训练后身体机能状态的调节效果.方法:选取处于冬训大负荷训练期间的河南男子皮艇运动员18名,随机分为实验组和对照组.实验组内服复方中药,对照组给予安慰剂,分别在服药前和服药后的第8d、第15d、第22 d、第29 d清晨取静脉血测定血红蛋白、肌酸激酶、尿素氮和睾酮,并于实验前后测试运动员3000m全力跑的运动成绩.结果:血红蛋白在实验组逐渐上升,对照组在实验结束后出现下降;肌酸激酶在对照组先上升后维持不变,实验组先上升后逐渐下降;尿素氮在对照组升高,实验组先上升后下降;睾酮在对照组逐渐下降,实验组逐渐升高;实验组3000 m全力跑成绩显著提高.结论:该中药方剂对调节运动员大负荷训练后的身体机能状态具有良好作用.%Aims:To observe the effects of Chinese medicine on male kayak athletes. Methods: eighteen male Henan male kayak athletes were randomly divided into experimental group and control group. The experiment was conducted in winter training. The experimental group administrated orally Chinese medicine, the 50 ml oral liquids were taken after lunch and supper. The elbow venous blod were drawn before breakfast before administration, on the eigth day, on the fifteenth day, on the twenty-second day, on the twenty-ninth day after administration, then hemoglobin (HB), creatine kinase (CK), Urea nitrogen (BUN), testosterone (T) were examined. Meanwhile, the achivement of 3000 meters run was tested before and after experiment. Results:The HB of experimental group rose and control group decreased;the CK of control group rose,keeping the status, the CK of experimental group rose before decline; the BUN of control group rose,the BUN of experimental group rose before decline; the T of experimental group rose and control group decreased; the achivement of 3000 meters run of experimental group

  14. The Volunteering Legacy of London 2012 Games. A Pilot Study.

    OpenAIRE

    2016-01-01

    The hosting of the London 2012 Olympic Games was seen as an opportunity to harness the enthusiasm of the 70000 volunteers involved and to provide a volunteer legacy post event. A total of 77 London 2012 volunteers completed a web-based open-ended survey. The participants were asked to indicate their level of current volunteering engagement and whether volunteering at the Games had an impact on their current volunteering levels. The study found that the London Olympics were the first volunteer...

  15. Motivations and Benefits of Student Volunteering: Comparing Regular, Occasional, and Non-Volunteers in Five Countries

    OpenAIRE

    Karen Smith; Kirsten Holmes; Debbie Haski-Leventhal; Cnaan, Ram A; Femida Handy; Brudney, Jeffrey L

    2010-01-01

    Programmes targeting student volunteering and service learning are part of encouraging civic behaviour amongst young people. This article reports on a large scale international survey comparing volunteering amongst tertiary students at universities in Australia, Canada, New Zealand, the United Kingdom, and the United States of America. The data revealed high rates of student volunteering and the popularity of occasional or episodic volunteering. There were strong commonalities in student volu...

  16. Do monetary rewards undermine intrinsic motivations of volunteers? Some empirical evidence for Italian volunteers

    OpenAIRE

    Fiorillo, Damiano

    2007-01-01

    Empirical studies show that intrinsic motivations increase the volunteer labour supply. This paper studies how monetary rewards to volunteers affect their intrinsic motivations. Using a sample of Italian volunteers, allowing to distinguish the type of volunteer, the paper shows that monetary rewards (extrinsic motivations) influence positively the choice to donate voluntary hours, while a low intrinsic motivation seems to decrease hours per week. Moreover, monetary rewards increase the hours ...

  17. Chinese and Foreign Elite Male 10 km Race Walking Athletes Race Walking Technology Comparative Analysis%中外优秀男子10公里竞走运动员竞走技术对比分析

    Institute of Scientific and Technical Information of China (English)

    叶小芳; 游永豪; 张阳; 周浩祥

    2015-01-01

    Research purposes:the analysis of Chinese and foreign elite male 10 km race walking athletes race walking technology characteristics and differences of from the perspective of technical movement analysis for the 2014 World Cup in the iaaf race walk-ing man 10 kilometers of Chinese and foreign excellent athletes in the match technique for diagnosis and analysis, and compari-son, to find the advantages and disadvantages of walkers walking technology in China, to provide the accurate movement technical reference for the coaches and athletes and suggestion. The main research method is motion technology film and image analytical method. Results:1) the Chinese athletes Gao Wen-kui gradually changed the traditional technology and characteristics of high frequency "small step", but the step increase led to a lower frequency. About basic step amplitude balance and center of gravity is moving fast. Leng Xiao but remains the technical features of high frequency"small step", and around the step amplitude unbal-ance, center of gravity move slower. 2) Gao Wenkui and foul Leng Xiao long hang time and close to the critical value. 3) on the top of the head fluctuation, Chinese athletes is better than foreign athletes. 4) compared with the foreign excellent athletes, the ankle of the walker stretching amplitude is smaller. 5) Gao Wenkui right leg touchdown instant knee Angle is not in conformity with the naked eye can be observed. 6) when the Chinese athletes in the vertical support the technical features of the knee joint Angle "the bow". Suggested our country athletes pay attention to the optimized combination of step length and step frequency, strictly control the hang time, to strengthen the ankle exercises.%研究目的:分析中外优秀男子10公里竞走运动员竞走技术的特点和差异.主要研究方法:运动技术拍摄和图像解析法.研究结果:1)中国运动员高文魁左右迈步幅度基本平衡,重心移动速度较快.冷晓左右迈步幅度不

  18. The Association between Baseline Subjective Anxiety Rating and Changes in Cardiac Autonomic Nervous Activity in Response to Tryptophan Depletion in Healthy Volunteers.

    Science.gov (United States)

    Hsiao, Chih Yin; Tsai, Hsin Chun; Chi, Mei Hung; Chen, Kao Chin; Chen, Po See; Lee, I Hui; Yeh, Tzung Lieh; Yang, Yen Kuang

    2016-05-01

    The aim of this study was to investigate the influence of serotonin on anxiety and autonomic nervous system (ANS) function; the correlation between subjective anxiety rating and changes of ANS function following tryptophan depletion (TD) in healthy volunteers was examined. Twenty-eight healthy participants, consisting of 15 females and 13 males, with an average age of 33.3 years, were recruited.Baseline Chinese Symptom Checklist-90-Revised and ANS function measurements were taken. TD was carried out on the testing day, and participants provided blood samples right before and 5 hours after TD. ANS function, somatic symptoms, and Visual Analogue Scales (VASs) were determined after TD. Wilcoxon signed rank test and Spearman ρ correlation were adapted for analyses of the results.The TD procedure reduced total and free plasma tryptophan effectively. After TD, the sympathetic nervous activity increased and parasympathetic nervous activity decreased. Baseline anxiety ratings positively correlated with post-TD changes in sympathetic nervous activity, VAS ratings, and physical symptoms. However, a negative correlation with post-TD changes in parasympathetic nervous activity was found.The change in ANS function after TD was associated with the severity of anxiety in healthy volunteers. This supports the fact that the effect of anxiety on heart rate variability is related to serotonin vulnerability. Furthermore, it also shows that the subjective anxiety rating has a biological basis related to serotonin.

  19. 大白菜细胞核雄性不育甲型“两用系”细胞学观察%Cytology Observation of Anther for Genic Male Sterility of AB Line Chinese Cabbage

    Institute of Scientific and Technical Information of China (English)

    许明; 郑鹏婧; 张欣; 毕高熵

    2012-01-01

    以大白菜细胞核雄性不育甲型“两用系”为材料,对其可育与不育株的花器结构进行比较,并进行细胞学观察来明确该雄性不育类型的败育时期及败育原因.结果表明,大白菜细胞核雄性不育甲型“两用系”可育株的萼片长、花瓣长、花瓣宽、雄蕊长和雌蕊长都极显著高于不育株对应部位;不育植株和可育植株花蕾大小与花发育时期相对应;不育花蕾在2.5 mm后就已经败育,败育时期可能发生在减数分裂后期到四分体时期,该时期绒毡层细胞液膨大、呈现液泡化,将四分体挤压到药室的中间,致使四分体大量发育异常,小孢子得不到营养,不能形成正常的小孢子,导致小孢子完全解体,在开花前败育.%In this experiment, the materials are genic male sterility of AB Line Chinese cabbage. Comparisons between sterile flower and fertile flower on flower organic structure in Chinese cabbage, and cytology observation of anther, to find out the stage and reason of abortion. The results showed that: the sepal length, petal length, petal width, the stamens length of fertile plants and sterile plants in Chinese cabbage are very obviously different; development of anther was observed by using acid carmine staining and paraffin section method, stertility has been aborted after 2. 5 mm, abortion may occur during after meiosis stage to tetrad stage, tapetal cells showed vacuolation and crushed tetrad into central parts during this period. A large number of tetrads become abnormal, microspore development can not enough space and nutrition. Finally, microspores completely resolved and cause abortion before flowering.

  20. A Guide for Co-ordinators of Volunteers and Volunteer Services in Schools.

    Science.gov (United States)

    Freund, Janet W., Comp.

    This manual for those responsible for matching teacher requests and student needs to volunteer services is applicable to a variety of school volunteer programs but concentrates on the type of volunteer service which evolved from the Winnetka, Illinois, project in which older citizens in the community form a "talent pool" to work to enrich the…

  1. Bioequivalence Study of Atorvastatin Tablets in Healthy Pakistani Volunteers.

    Science.gov (United States)

    Mohammad, Sohail; Arshad, Usman; Abbass, Nasir; Parvez, Irfan; Abbas, Ghulam; Mahmood, Wajahat

    2015-01-01

    A two way, randomized cross-over bioequivalence study was conducted to analyse the rate and extent of absorption of atorvastatin after a single dose of 80 mg atorvastatin as atorvastatin calcium tablets. The study was carried out using healthy male volunteers (N = 24). A high performance liquid chromatography method was employed to determine the level of drug in human plasma. It was concluded that the test and the reference drug exhibited comparable values of pharmacokinetic parameters. It was also concluded that since there was no significant difference between the rate and extent of absorption of the drug from the test and the reference formulations: these two formulations could thus be declared bioequivalent.

  2. [Male contraception].

    Science.gov (United States)

    Demoulin, A

    1984-04-01

    Among the reasons why male hormonal contraception has lagged behind female methods are the necessity of preserving virility, the fact that spermatogenesis is a continuous process, the need to control secondary effects and toxicity, and the requirement that modes of administration be acceptable to both partners. Among currently available reversible mehtods, withdrawal is undoubtedly the most ancient. It is still widespread but cannot be recommended because of its limited effectiveness. The condom is used by about 10% of couples worldwide as a principal or temporary method, but its inter-ference with sensation has limited its acceptance. Condoms are nevertheless highly effective when used with a spermicide. Various androgens are currently under investigation. High doses of testosterone can induce azoospermia without affecting libido but their side effects may be serious. The use of combinations of steroids permits doses to be reduced and offers promise for the future. The combination of oral medroxyprogesterone acetate and percutaneous testosterone is one of the better approaches; the combination is effective and nontoxic but has the disadvantage of percutaneous administration. Gossypol, a pigment extracted from the cotton plant, has been used as a contraceptive in China with a reported efficacy of 99.89%, recovery of fertility within 3 months, and no effect on future fertility. However, its toxicity appears to be significant in the animal and its reversibility is uncertain. A search is on for analogs which would preserve the contraceptive effects while eliminating toxic effects. Several gonadotropin releasing hormone (GnRH) analogs under investigation for their interference with spermatogenesis have given promising results. Several chemicals tested for contraceptive effects have had unacceptably high toxicity. Chinese investigators have reported good results with various physical methods of interfering with sperm production, but their reversibility and innocuity

  3. Meaningful Commitment: Finding Meaning in Volunteer Work

    Science.gov (United States)

    Schnell, Tatjana; Hoof, Matthias

    2012-01-01

    This study tests the hypothesis that volunteer work is associated with various aspects of meaning making by employing a multi-dimensional model of meaning operationalized by the "Sources of Meaning and Meaning in Life Questionnaire" ("SoMe"). An empirical study comparing 168 volunteers with a representative sample of the general population (N =…

  4. Skill Development for Volunteering in Rural Communities

    Science.gov (United States)

    Kilpatrick, Sue; Stirling, Christine; Orpin, Peter

    2010-01-01

    This paper examines the skills required of volunteers in the voluntary sector organisations that operate in three rural Tasmanian communities. It reports how volunteers acquire those skills and reveals the challenges faced by voluntary sector organisations in rural communities whose industries and, following from this, community members have a…

  5. Sumatriptan and cerebral perfusion in healthy volunteers.

    Science.gov (United States)

    Scott, A K; Grimes, S; Ng, K; Critchley, M; Breckenridge, A M; Thomson, C; Pilgrim, A J

    1992-04-01

    1. The effect of sumatriptan on regional cerebral perfusion was studied in healthy volunteers. 2. Intravenous sumatriptan (2 mg) had no detectable effect on regional cerebral perfusion as measured using a SPECT system with 99technetiumm labelled hexemethylpropyleneamineoxime. 3. Sumatriptan had no effect on pulse, blood pressure or ECG indices. 4. All six volunteers experienced minor adverse effects during the intravenous infusion.

  6. Training Shelter Volunteers to Teach Dog Compliance

    Science.gov (United States)

    Howard, Veronica J.; DiGennaro Reed, Florence D.

    2014-01-01

    This study examined the degree to which training procedures influenced the integrity of behaviorally based dog training implemented by volunteers of an animal shelter. Volunteers were taught to implement discrete-trial obedience training to teach 2 skills (sit and wait) to dogs. Procedural integrity during the baseline and written instructions…

  7. Corporate volunteering - motivation for voluntary work

    Directory of Open Access Journals (Sweden)

    Debora Azevedo

    2008-07-01

    Full Text Available Nowadays, when the welfare state is a responsibility of the entire society, organizations in the private sector assume co-responsibility for social issues. They are also pressured by the challenges presented by technological advances and the globalization , involving new parameters and requirements for quality. In this context, the concept of Corporate Social Responsibility (RSC emerges as an option for solutions to the issues related to the company and the whole community. Among the actions of the RSC is the Corporate Volunteering-program, which aims to promote / encourage employes to do voluntary work. A central issue when talking about volunteering is the withdrawal of these (SILVA and FEITOSA, 2002; TEODÓSIO, 1999 and, in accordance with the Community Solidarity (1997, one of the possible causes for the withdrawal is the lack of clarity as to the motives and expectations that lead the person to volunteer themselves. This study uses qualitative research and triangulation of feedback from volunteers, coordinators of volunteers and social organizations, to present a framework from which it is possible to analyze the various motivations for the volunteer work. Key words: Corporate Volunteering program. Volunteering. Corporate social responsibility.

  8. Volunteer map data collection at the USGS

    Science.gov (United States)

    Eric, B. Wolf; Poore, Barbara S.; Caro, Holly K.; Matthews, Greg D.

    2011-01-01

    Since 1994, citizen volunteers have helped the U.S. Geological Survey (USGS) improve its topographic maps. Through the Earth Science Corps program, citizens were able to "adopt a quad" and collect new information and update existing map features. Until its conclusion in 2001, as many as 300 volunteers annotated paper maps which were incorporated into the USGS topographic-map revision process.

  9. Student Volunteering in England: A Critical Moment

    Science.gov (United States)

    Darwen, Jamie; Rannard, Andrea Grace

    2011-01-01

    Purpose: The purpose of this paper is to present the current state of student volunteering in English universities, and show how it contributes to some of the core activities of higher education, including teaching and learning, employability, and public engagement. The paper goes on to describe challenges currently faced by student volunteering,…

  10. Senior Volunteers: Helping Hands & Willing Workers.

    Science.gov (United States)

    Wessely, Michael

    1995-01-01

    Volunteers and other community-based assistants can relieve some of the financial burden brought on by school-budget cutbacks. This publication describes how enlisting the help of senior volunteers and workers benefits both children and seniors, and it presents some guidelines for implementation of intergeneration programs. The programs provide…

  11. Matching Expectations for Successful University Student Volunteering

    Science.gov (United States)

    Paull, Megan; Omari, Maryam; MacCallum, Judith; Young, Susan; Walker, Gabrielle; Holmes, Kirsten; Haski-Leventha, Debbie; Scott, Rowena

    2017-01-01

    Purpose: The purpose of this paper is to demonstrate the importance of expectation formation and matching for university student volunteers and their hosts. Design/methodology/approach: This research involved a multi-stage data collection process including interviews with student volunteers, and university and host representatives from six…

  12. The Origin of Chinese Characters

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    女 (nü) is a pictograph. InChinese it means female, theopposite of male. In ancientChinese, women had low socialstatus which is reflected in theshape of the character. 女 in theOracle-Bone Script looks like a

  13. The comparison of self esteem between volunteer and non volunteer students in universities sport in Iran

    Directory of Open Access Journals (Sweden)

    Reza Andam.

    2012-03-01

    Full Text Available Studies three concepts of transformational, transactional and laissez-faire leaderships as three independent and individual dimensions. This field study is descriptive and correlative. Statistical population of this study is the volunteer students in universities' sport associations of 10 regions of the country. Among 73 universities, 17 had active sport associations. Based on Morgan table, 231 students were selected as statistical sample (n=231 from which the results of 208 questionnaires were analyzed. Bass and Avolio (1995 Multifactor Leadership Questionnaire (MLQ was used to measure managers' leadership style of the universities' sport administrations. This questionnaire includes 41 questions with 5-value Lickert scale (1=never to 5=always. Choosing satisfaction from experiencing as the most important dimension of satisfaction shows volunteers' high level of satisfaction from experiences they have acquired in universities sport associations. The reason of this fact is that sport activity in the association is long term in nature. Sport association provides the students an opportunity to experience and use their experiences in their sport and work life. This study illustrates that girls are more satisfied than boys in all satisfaction dimensions (especially acquiring experience, career, commitment, and material in sport associations. Researches show that female students' satisfaction is more than male students' satisfaction and women's job satisfaction is more than men's job satisfaction. Thus, the higher degree of job satisfaction and experiencing in female students seems more justifying. Also, it's been cleared that sport students were more satisfied than other students in all satisfaction dimensions (especially acquiring experience, career, purposeful, and commitment

  14. HLA-B67 may be a male-specific HLA marker of susceptibility to relapsed childhood ALL in Hong Kong Chinese and HLA-A33 or HLA-B17 signifies a higher presentation leukocytosis: A retrospective analysis on 53 transplant candidates (1989-2003).

    Science.gov (United States)

    Ng, Margaret H L; Lau, K M; Hawkins, B R; Chik, K W; Chan, Natalie P H; Wong, W S; Tsang, K S; Shing, Matthew M K; Li, C K

    2006-08-01

    We performed a retrospective analysis on the human leukocyte antigen (HLA) data of 53 consecutive Chinese patients with high-risk childhood acute lymphoblastic leukemia (ALL) diagnosed from 1989 to 2003. A significantly higher frequency of HLA-B67 in the male relapse group of patients [OR, 23.08; 95% CI, 5.31-100.36; p = 0.0042; for statistical significance after Bonferroni correction (Bc) p (Bc) B17 (p < 0.001) signifies higher leukocytosis at presentation. Taken together, our findings support the involvement of HLA in Chinese high-risk childhood ALL.

  15. Safety evaluation of saffron (Crocus sativus) tablets in healthy volunteers.

    Science.gov (United States)

    Modaghegh, Mohammad-Hadi; Shahabian, Masoud; Esmaeili, Habib-Allah; Rajbai, Omid; Hosseinzadeh, Hossein

    2008-12-01

    Saffron (Crocus sativus) stigma tablets were evaluated for short-term safety and tolerability in healthy adult volunteers. The study was a double-blind, placebo-controlled design consisting of a 1 week treatment of saffron tablets. Volunteers were divided into 3 groups of 10 each (5 males and 5 females). Group I received placebo; groups 2 and 3 received 200 and 400mg saffron tablets, respectively, for 7 days. General measures of health were recorded during the study such as hematological, biochemical and electrocardiographic parameters done in pre- and post-treatment periods. Clinical examination showed no gross changes in all volunteers after intervention. Saffron with higher dose (400mg) decreased standing systolic blood pressure and mean arterial pressures significantly. Saffron decreased slightly some hematological parameters such as red blood cells, hemoglobin, hematocrit and platelets. Saffron increased sodium, blood urea nitrogen and creatinine. This study showed that saffron tablets may change some hematological and biochemical parameters. However, these alterations were in normal ranges and they were not important clinically.

  16. Personality Traits and Motives for Volunteering

    Directory of Open Access Journals (Sweden)

    Marija Juzbasic

    2015-07-01

    Full Text Available The aim of this study was to test the possibility of predicting volunteer motives based on five-factor model of personality in a sample of 159 volunteers from Zagreb, Osijek and Split. Data was collected using IPIP-300 personality questionnaire and Volunteer Functions Inventory. Results indicate that Croatian volunteers are agreeable, conscientious, altruistic, dutiful, and moral persons with artistic interests. Their most salient motives for volunteering are understanding and values. Hierarchical regression analysis confirmed that the five-factor model personality traits independently predict 17% of protective motive variance, 12% of values motive, 18% of career motive, 10% of understanding motive, and 12% of enhancement motive. Social motive was not explained by personality traits.

  17. Association of L-FABP T94A and MTP I128T polymorphisms with hyperlipidemia in Chinese subjects.

    Science.gov (United States)

    Tian, Yingying; Li, Hui; Wang, Shanbo; Yan, Jin; Chen, Zhiheng; Li, Zhenyu; Feng, Han; Zhou, Honghao; Ouyang, Dongsheng

    2015-03-01

    The purpose of this study was to evaluate the relation between the L-FABP T94A and MTP I128T polymorphisms and hyperlipidemia in Chinese subjects. We recruited 390 volunteers: 201 hyperlipidemic and 189 healthy volunteers. The L-FABP T94A and MTP I128T polymorphisms were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Anthropometry, lipid profile, and liver function of the subjects were determined. We observed that male carriers of the L-FABP A94 allele had significantly higher body weight (P = 0.012), higher body mass index (BMI) (P = 0.014), and higher plasma triacylglycerol levels (TAG) (P = 0.033) and lower ratios of high-density lipoprotein cholesterol (HDL-C) to total cholesterol (TC) (P = 0.008) than T94 homozygotes. The MTP T128 allele was associated with significantly lower serum TC (P L-FABP T94A polymorphisms can affect serum lipid levels in the Chinese population. The MTP T128 allele offers protection against hyperlipidemia in the Chinese population.

  18. Organizational Support and Volunteering Benefits for Older Adults

    Science.gov (United States)

    Tang, Fengyan; Choi, Eunhee; Morrow-Howell, Nancy

    2010-01-01

    Purpose: This study tested a theoretical model of volunteering benefits and examined the mechanism through which volunteering benefits older adults. Design and Methods: This is a 2-wave study of 253 older adult volunteers serving in 10 volunteer programs. Older volunteers completed the mailed surveys in 2005 and 2006. Structural equation modeling…

  19. Top Ten Myths and Realities of Working with Teen Volunteers.

    Science.gov (United States)

    Shoemaker, Kellie

    1998-01-01

    Discusses misconceptions about teen volunteers in public libraries: teens who hang out make good volunteers; teens who apply want to work; parents aren't important; incorporating volunteers is easy; enthusiasm means commitment; volunteers will tell you if they don't enjoy the job; non-performers are easy to fire; teens volunteer because they need…

  20. 45 CFR 1217.6 - Roles of volunteers.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Roles of volunteers. 1217.6 Section 1217.6 Public... VISTA VOLUNTEER LEADER § 1217.6 Roles of volunteers. VISTA volunteer leaders may have the following roles: (a) Primary contact with VISTA volunteers on personal and administrative matters. (b) Aid...

  1. Program Evaluation of "Young at Heart": Examining Elderly Volunteers' Generativity.

    Science.gov (United States)

    Scott, Jean Pearson; Reifman, Alan; Mulsow, Miriam; Feng, Du

    2003-01-01

    Elderly volunteers in the Young at Heart child care program (n=14), Meals on Wheels (n=14), other volunteer activities (n=24), and nonvolunteers (n=49) were compared. Although child-care volunteers were expected to score highest in generativity, volunteers in other activities did, followed by Young at Heart volunteers. (Contains 10 references.)…

  2. Clinical characteristics and follow-up of 5 young Chinese males with gonadotropin-releasing hormone deficiency caused by mutations in the KAL1 gene

    Directory of Open Access Journals (Sweden)

    Juan Li

    2016-02-01

    Full Text Available Isolated gonadotropin-releasing hormone (GnRH deficiency (IGD pertains to a group of genetic disorders consisting of anosmic hypogonadotropic hypogonadism (Kallmann syndrome, KS and normosmic idiopathic hypogonadotropic hypogonadism (nIHH. KS is genetically heterogeneous. We hereby present 5 young male patients with GnRH deficiency caused by mutations in the KAL1 gene. Their ages ranged from 9 months to 16 years. They were referred to our department for an endocrine consultation for micropenis. Hormone assays showed low circulating gonadotropins and testosterone. Molecular studies revealed KAL1 mutations in all cases, three reported nonsense sequence variants in the KAL1 gene were detected in 4 patients, respectively (c.784C > T (p.Arg 262*, c.1267C > T (p.Arg423*, and c.1270C > T (p.Arg424*, and one patient harbored a novel hemizygous sequence variant [c.227G > A (p.Trp76*]. Only one patient presented short stature without growth hormone deficiency and anosmia. Another patient had bilateral eyelid ptosis, trichiasis, and refractive error. This is the first report on the co-occurrence of a KAL1 gene mutation and tent-like upper lip in four patients. All of our cases had normal olfactory bulbs and showed no renal agenesis, cleft lip/palate, and hearing impairment. These cases expand our knowledge of the phenotype associated with KAL1 sequence variations, although the precise mechanism by which KAL1 gene influences the development of this phenotype is still unknown.

  3. LC-MS-MS analysis of 2-pyridylacetic acid, a major metabolite of betahistine: application to a pharmacokinetic study in healthy volunteers.

    Science.gov (United States)

    Chen, X Y; Zhong, D F; Duan, J L; Yan, B X

    2003-12-01

    1. A sensitive liquid chromatographic-tandem mas spectrometric assay was developed and validated to determine the major metabolite of betahistine, 2-pyridylacetic acid, in human plasma. 2. The analyte was extracted from plasma samples by liquid-liquid extraction and analysed using liquid chromatography-tandem mass spectrometry with an electrospray ionization interface. The method has a lower limit of quantitation of 1 ng ml(-1) fir a 0.5-ml plasma aliquot. The intra- and interday precision (relative standard deviation), calculated from quality control (QC) samples, was less than 10%. Accuracy as determined from QC samples was within +/-7%. 3. The validated method was successfully applied to a pharmacokinetic study of betahistine in healthy volunteers. After oral administration of a single dose of 24 mg betahistine mesylate to 20 healthy Chinese male volunteers, Cmax was 339.4 ng ml(-1) (range 77.3-776.4 ng ml(-1)). The t(1/2) was 5.2 h (range 2.0(-1)-11.4h). The AUC(0-t) obtained was 1153.5 ng ml(-1) h (range 278.5-3150.8 ng ml(-1)). The disposition of the metabolite exhibited a marked interindividual variation. 4. The plasma concentrations of the parent drug were less than 0.5 ng ml(-1), suggesting that it undergoes almost complete first-pass metabolism. The reported two active metabolites were not detected in the plasma of any volunteer. Although there is no evidence that the major metabolite has pharmacological activity, the clinical importance of 2-pyridylacetic acid in humans should be reinvestigated.

  4. Volunteers for Researchers’ Night wanted

    CERN Multimedia

    Katarina Anthony

    2015-01-01

    Every year, on the last Friday of September, the European Researchers’ Night (see here) takes place in about 300 cities all over Europe - promoting research in engaging and fun ways for the general public. This year, CERN will be participating once again, hosting dozens of events across the Balexert shopping centre – and we’ll need YOUR help to make the celebration a success.   From film screenings and celebrity Q&A sessions to “Ask a Researcher” and build-your-own LEGO LHC events, this year’s Researchers’ Night is going to be jam-packed! The fun will kick off prior to the night itself with a mock-up of the LHC tunnel installed in the central court of the Balexert shopping centre, 8-12 September*. CERN people will be on hand to speak to shoppers about the LHC, and to encourage them to participate in Researchers’ Night! The CERN organisers are recruiting volunteers and support staff for Researchers’ ...

  5. Dexamethasone prolongs local analgesia after subcutaneous infiltration of bupivacaine microcapsules in human volunteers

    DEFF Research Database (Denmark)

    Holte, Kathrine; Werner, Mads U; Lacouture, Peter G;

    2002-01-01

    BACKGROUND: The addition of small amounts of dexamethasone to extended-release formulations of bupivacaine in microcapsules has been found to prolong local analgesia in experimental studies, but no clinical data are available. METHODS: In a double-blinded study, 12 healthy male volunteers were ra...

  6. Analysis of rear-end impact response using mathematical human modeling and volunteer tests

    NARCIS (Netherlands)

    Meijer, R.; Hoof, J.F.A.M. van; Ono, K.; Kaneoka, K.

    2001-01-01

    At TNO multi-directional mathematical human body models have been developed. The objective of this study was to simulate the rigid seat and standard seat JARI rear-impact sled tests using the MADYMO 50th percentile male model. The head and neck response of this human model and the volunteers were co

  7. Acute cortisol administration modulates EEG alpha asymmetry in volunteers : relevance to depression

    NARCIS (Netherlands)

    Tops, M; Wijers, AA; van Staveren, ASJ; Bruin, KJ; Den Boer, JA; Meijman, TF; Korf, J

    2005-01-01

    The acute effects of cortisol (35 mg) administration in 11 healthy male volunteers on resting frontal EEG asymmetry measured in the alpha band were investigated, using a within-subjects double-blind design. Results were indicative of a relative increase of right frontal activity with cortisol. This

  8. Motivations for Deceased Organ Donation Among Volunteers in China: A Qualitative Research Study.

    Science.gov (United States)

    Yin, Zhike; Liu, Shan; Yan, Jin; Liu, Jia

    2016-06-09

    BACKGROUND To align with guiding principles on human organ and tissue transplantation published by the World Health Organization (WHO), the Red Cross Society of China (RCSC) launched a new nationwide organ donation program in 2010 to recruit organ donation volunteers. Despite severe shortage of donated organs, there is a very low rate of volunteering for organ donation among the Chinese population (only 0.03 donors per million population) in the national program. Motivating organ donation is the key to the success of organ transplantation in China. MATERIAL AND METHODS Semi-structured 45- to 60-min interviews were conducted among 34 volunteers. Data analysis was performed with Nvivo 8.0 software. RESULTS Six motivations for organ donation were identified: helping others/altruism, fulfilling long-cherished wishes, reducing the burdens, making the best use of everything, giving back to society, and life extension. Factors affecting the motivation of organ donation among volunteers in China included traditional values, personal experiences, role model effect, family support, and problems in the donation system. Possible strategies to improve organ donation included fostering a scientific concept of the body and death, focusing donation promotion efforts on certain groups, and simplifying the process of organ donation. CONCLUSIONS There are multiple reasons for Chinese people to register for organ donation, with helping others as the central motivation.

  9. Comparative bioequivalence study of leflunomide tablets in Indian healthy volunteers.

    Science.gov (United States)

    Agarwal, S; Das, A; Ghosh, D; Sarkar, A K; Chattaraj, T K; Pal, T K

    2012-03-01

    The pharmacokinetics of teriflunomide [CAS No. 163451-81-8], the metabolite of leflunomide [CAS No. 75706-12-6] has been evaluated in adult human volunteers after oral administration of tablet formulation. However, no published data is available regarding the bioavailability of this in the Indian population. In light of the above, a study was designed to carry out a bioequivalence study of 2 preparations of leflunomide 20 mg in healthy Indian male volunteers.24 healthy male volunteers (age, 25±4.1 years; weight, 57.58±7.01 kg) were enrolled in this study. Each subject received a test and reference formulation in a single dose, fasting 2 period, 2 way crossover study with a wash out period of 4 weeks. Analysis of teriflunomide from plasma samples was done by a simple and sensitive HPLC method using UV detection developed in our laboratory. An analysis of variance was performed on the pharmacokinetic parameters Cmax, AUC0-t, AUC0-∞ using GLM procedures in which sources of variation were subject, formulation, and period.The results indicated that there are no statistically significant differences between the 2 products in either the mean concentration-time profiles or in the obtained pharmacokinetic parameters. 90% confidence limits for the log transformed data of Cmax, AUC0-t, AUC0-∞. were within the acceptable range of 0.80-1.25.The results indicate that the 2 products are bioequivalent in terms of rate and extent of drug absorption. Both the preparations were well tolerated with no adverse reactions throughout the study.

  10. Becoming an Older Volunteer: A Grounded Theory Study

    Directory of Open Access Journals (Sweden)

    Janet Witucki Brown

    2011-01-01

    Full Text Available This Grounded Theory study describes the process by which older persons “become” volunteers. Forty interviews of older persons who volunteered for Habitat for Humanity were subjected to secondary content analysis to uncover the process of “becoming” a volunteer. “Helping out” (core category for older volunteers occurs within the context of “continuity”, “commitment” and “connection” which provide motivation for volunteering. When a need arises, older volunteers “help out” physically and financially as health and resources permit. Benefits described as “blessings” of volunteering become motivators for future volunteering. Findings suggest that older volunteering is a developmental process and learned behavior which should be fostered in older persons by personally inviting them to volunteer. Intergenerational volunteering projects will allow older persons to pass on knowledge and skills and provide positive role modeling for younger volunteers.

  11. 'Making a Difference': Volunteer Tourism and Development,

    OpenAIRE

    Butcher, Jim; Smith, Peter

    2010-01-01

    Abstract: \\ud \\ud In recent decades there has been a boom in international volunteer tourism, mainly in the form of the growth of gap-year companies offering placements, linked to conservation and community well-being goals. This paper makes two points: firstly, it argues that the growth of volunteer tourism is in part a product of the politics of the current period – the decline of grand narratives and the growth of ‘life political’ alternative forms of agency. Hence volunteer tourism, motiv...

  12. 75 FR 20891 - National Volunteer Week, 2010

    Science.gov (United States)

    2010-04-21

    ... nothing in return. The American story is a story of volunteers--of patriots who fought for our founding... Americans are answering that call. From mentoring a student and feeding the homeless, to rebuilding after...

  13. Monitoring and Evaluation of Volunteer Tourism

    DEFF Research Database (Denmark)

    Taplin, Jessica; Dredge, Dianne; Scherrer, Pascal

    2014-01-01

    in the project planning and implementation cycles of volunteer tourism organisations and destination managements. However, they can be both value-laden and politically charged, making an understanding of context, purpose and various approaches to monitoring and evaluation important. Drawing from evaluation......The rapid expansion and commercialisation of the volunteer tourism sector and the potential for negative impacts on host communities have put the sector under increasing scrutiny. Monitoring and evaluation are key aspects of sustainable tourism planning and management, and play important roles...... highlights the important influence of context (the issue the volunteer tourism programme is addressing, the nature of the intervention, the setting, the evaluation context and the decision-making context), and identifies four dimensions of volunteer tourism (stakeholders, organisations, markets...

  14. Measuring the Dollar Value of Volunteering.

    Science.gov (United States)

    Ironmonger, Duncan

    1998-01-01

    Describes the use of sample surveys to estimate the amount of time spent volunteering. States that it is necessary to estimate the number of hours involved and to establish an appropriate value per hour. (SK)

  15. Volunteering Internationally: Why, Where and How.

    Science.gov (United States)

    Frost, David E; Kelly, Nancy A

    2015-12-01

    Oral health volunteers have an important role in addressing oral health care shortages around the world, but to be effective they need to understand and prepare for the challenges of working overseas.

  16. 小白菜不育系应用防虫网熊蜂制种效果初探%Use of Bumblebee for Hybrid Seed Production of Chinese Cabbage Based on Male Sterile Lines in Insect-proof Net Cage

    Institute of Scientific and Technical Information of China (English)

    韦武青; 马志; 宋春; 叶小松; 沈新华; 王浩挻; 高伟

    2011-01-01

    2009-2010年采用熊蜂在镇江市蔬菜研究所防虫网内进行小白菜雄性不育系制种.结果表明,利用熊蜂授粉能显著提高制种产量,熊蜂授粉种子产量较本地蜜蜂授粉种子产量提高146.7%,较人工辅助授粉种子产量提高15.9%;熊蜂制种较人工辅助授粉种子纯度提高3.5%;利用熊蜂在防虫网内进行小白菜不育系制种是可行的.%The use of bumblebee in seed production of Chinese cabbage male-sterile line in insect-proof net cage has been tested at Zhenjiang Vegetable Institute during 2009-2010. The results showed that bumblebee can significantly improve bybrid seed production based on Chinese cabbage male-sterile line. The hybrid seed yield was 246.7% of local honey bees and 115.9% of hand pollination. The hybrid seed purity also increased 3.5% compared with hand pollination. It is practical to use bumblebee for hybrid seed production base on male sterile lines of Chinese cabbage in insect-proof net cages.

  17. Holding on to what you have got: keeping hospice palliative care volunteers volunteering.

    Science.gov (United States)

    Claxton-Oldfield, Stephen; Jones, Richard

    2013-08-01

    In all, 119 hospice palliative care volunteers from 3 community-based hospice programs completed the Volunteer Retention Questionnaire (VRQ), a 33-item survey designed for this study. The VRQ asks volunteers to rate the importance of each item to their decision to continue volunteering. The items that received the highest mean importance ratings included enjoying the work they do, feeling adequately prepared/trained to perform their role, and learning from their patients' experiences/listening to their patients' life stories. Being recognized (eg, pins for years of service or being profiled in the hospice newsletter), receiving phone calls/cards from their volunteer coordinator on special occasions, and being reimbursed for out-of-pocket expenses were among the items that received the lowest mean importance ratings. Suggestions for improving volunteer retention are provided.

  18. 大学生志愿者评价体系调查与研究--以北京中医药大学为例%The Investigation and Research College Student Volunteer Service Evaluation Mechanism--Take Beijing University of Chinese Medicine for Example

    Institute of Scientific and Technical Information of China (English)

    常江梦; 李享; 刘娜娜; 李智鹏

    2015-01-01

    Today for colege students especialy medical colege students, because everyone has a social practice work, volunteer service has become a part of university life essential. However because it is in the colege student, social experience, service skils, etc. there is a lack of, colege students volunteer service in the end in the society produce what kind of impact remains to be studied, the volunteer service exits both advantages and disadvantages, society and universities for volunteer service evaluation mechanism is deficient and even blank, which is not good for improving the enthusiasm of volunteers to take part in the volunteer service. According to the survey, this paper discusses the above several aspects, put forward reasonable suggestions for volunteer service evaluation mechanism.%当今对于高校大学生特别是医学院学生来说,因每个人都有社会实践任务,志愿服务已成为大学生活中必不可少的一部分。然而由于处于学生时代的大学生,社会经验、服务技能等方面存在欠缺,大学生的志愿服务到底在社会产生怎样的影响仍有待研究,志愿服务优缺点并存,社会及高校针对志愿服务评价机制更是存在欠缺甚至空白,不利于提高志愿者参与志愿服务的热情和进行志愿服务的质量。该文将根据所做调查,就以上几方面展开论述,以期为志愿者服务评价机制提出合理建议。

  19. Motivations, Death Anxiety, and Empathy in Hospice Volunteers in France.

    Science.gov (United States)

    Garbay, Meriem; Gay, Marie-Claire; Claxton-Oldfield, Stephen

    2015-08-01

    This study examined the motivations for volunteering of hospice volunteers in France. In addition, their levels of death anxiety and empathy were measured and compared with those of French non-hospice volunteers and non-volunteers. Three questionnaires-the Inventory of Motivations for Hospice Palliative Care Volunteerism (IMHPCV), the Templer/McMordie Death Anxiety Scale, and the Interpersonal Reactivity Index-were sent via an Internet link to 2 hospice volunteer associations and to non-hospice volunteers and non-volunteers (only the hospice volunteers received the IMHPCV). Altruistic motives had the most influence on the respondents' decision to become a hospice volunteer. French hospice volunteers scored significantly lower on 3 categories of motives on the IMHPCV compared to a sample of Canadian hospice palliative care volunteers (study 2), suggesting that cultural differences may be involved. No significant differences were found in levels of death anxiety or empathy between the 3 groups of respondents of the study.

  20. Stability of Tactics and Psychology is the Key to Decide the Placing of Chinese Male Curling Team in 2014 Sochi Winter Olympics-Analyzing Tactics Level of Chinese Male Curling Team in 2013 World Curling Championship%战术和心理稳定性是决定中国男子冰壶队2014年索契冬奥会名次的关键--2013年冰壶世锦赛中国冰壶男队技战术水平分析

    Institute of Scientific and Technical Information of China (English)

    李洪臣; 许水生; 苏和; 吴月滨

    2013-01-01

    The stability of tactics and psychology is the key to decide the placing of Chinese male curling team in the 2014 Winter Olympics in Sochi .With the methods of literature , logic inference and data analysis , the paper has an analysis of Chinese male curling team's technique and tactics level in 2013 World Curling Championship .The results show that Chinese male curling team and individual technique have played well in the World Championship , the performance of is very good , but there are some problems which are unrea-sonable tactics , unstable four bases and forcing a bad key .The paper points out that Chinese male curling team should pay attention to train tactics ideas and improve four bases athletes'ability of keeping stability , in order to improve the overall performance and lay a good foundation for another success in 2014 Winter Olym-pics in Sochi , Russia .%战术和心理稳定性是决定中国男子冰壶队2014年索契冬奥会名次的关键。采用文献资料法、逻辑推理法和数据分析法,对2013年冰壶世锦赛中国冰壶男队技战术水平进行分析,研究结果表明此次世锦赛上中国冰壶男队在全队和个人冰壶技术上都有出色的发挥,成绩也相对较理想,但是也存在战术不合理和四垒不稳定,关键球处理不到位等情况;指出中国冰壶男队应该重视战术意识的培养和提高四垒队员保持稳定状态的能力,从而提高冰壶队整体成绩,为在2014年俄罗斯索契冬奥会上再创佳绩打好基础。

  1. Age dependent white matter lesions and brain volume changes in healthy volunteers

    DEFF Research Database (Denmark)

    Christiansen, P; Larsson, H B; Thomsen, C

    1994-01-01

    The brain of 142 healthy volunteers aged 21 to 80 years were investigated using MR imaging. The number and size of the white matter hyperintensity lesions (WMHL) in the cerebral hemispheres were determined. Furthermore, the volume of the cerebral hemispheres and of the lateral ventricles...... was measured. An almost linear increase in the number of volunteers with WMHL was seen with aging for males and females. With aging a significant decrease in the volume of the cerebral hemispheres was found for males, and a significant increase in the volume of the lateral ventricles was seen for both males...... and females. Our results suggest that with aging central atrophy increases more (relatively) than cortical atrophy. No correlation was found between the decreasing volume of the cerebral hemispheres and the increasing number and size of WMHL, nor between the increasing volume of the lateral ventricles...

  2. Neighbourly Acts--Volunteering, Social Capital and Democracy.

    Science.gov (United States)

    Wilkinson, Jennifer; Bittman, Michael

    2002-01-01

    Robert Putnam's view of social capital considers the decline in volunteering as a crisis for democracy. However, data on volunteering in Australia from 1974-1997 indicate that there is likely to be a significant increase in total volunteer hours. Beyond the contribution to democratic society, the values implicit in volunteering increase the…

  3. Characteristics of the Essence of Volunteering in Psychology

    Science.gov (United States)

    Shagurova, Angelina Alexandrovna; Ivanovna, Efremova Galina; Aleksandrovna, Bochkovskaya Irina; Denisenko, Sergey Ivanovich; Valerievich, Tarasov Mihail; Viktorovna, Nekrasova Marina; Potutkova, Svetlana Anatolievna

    2016-01-01

    The article discusses the basic ideas of volunteering; it analyzes the data of psychological studies on social activity and it highlights the importance of studying the motivational part of volunteering. The conclusion on structure and content of volunteering is made. Key focus is on the fact that volunteering is of particular importance in the…

  4. Male Infertility

    Science.gov (United States)

    ... the urethra. Chromosome defects. Inherited disorders such as Klinefelter's syndrome — in which a male is born with ... or major abdominal or pelvic surgery Having a history of undescended testicles Being born with a fertility ...

  5. The White Lion Volunteer Program in South Africa: A Study of Volunteer Needs

    Directory of Open Access Journals (Sweden)

    Boretti Tanya

    2014-01-01

    Full Text Available Volunteer tourists are motivated to participate in volunteer programs due to their need to ‘do something different’, ‘see another culture’ and ‘to escape’, amongst others. The research aims to determine the internal and external factors that motivate individuals to participate in the Tsau! Global White Lion Protection Trust’s (GWLPT volunteer program. Maslow’s theory of human motivation and Frankl’s study of human behaviour are used to explore intrinsic factors whereas extrinsic or macro environmental factors of influence are also investigated. A mixed method approach with focus group discussions and an online survey is followed. A background to the volunteer program is presented with the activities available to volunteers. The key findings indicate that most volunteers are young females that volunteer for a minimum of two weeks; are internally motivated to ‘give back and be useful’ and ‘to work with the white lions’ for the purpose of self-actualisation. External motivation is mainly social in terms of concern about the well-being of the lions, and South Africa being an economically affordable destination. The GWLPT strives to fulfil the needs of volunteers, especially intrinsic needs associated with self-actualisation and self-transcendence.

  6. Male sexuality.

    Science.gov (United States)

    Ginsberg, Terrie B

    2010-05-01

    It should be recognized that sexuality in the aging male is of such import that a complete sexual history must be performed. By taking a complete sexual history, facts can be obtained that will allow for appropriate focus relating to a holistic evaluation and will enable us to dispel antiquated sexual myths pertaining to the aging male. If initiated by the history taker, questions concerning sexuality may be discussed more comfortably by the patient. Erectile dysfunction, male sexual response cycle, testosterone, sexually transmitted diseases, human immunodeficiency virus, long-term illness, along with religion and culture are explored in this article with the aim of improving one's knowledge base, self reflection, and awareness of the importance of male sexuality. A complete understanding and appreciation of the aging male's medical history, surgical history, social history, and emotional history as well as his sexual, cultural, and religious concepts will allow the health care provider to better analyze information, and to recommend and provide appropriate advice and treatment to the aging male patient.

  7. 国产复方利福平片与进口 rifater在中国志愿者的药动学与相对生物利用度的研究%Studies on the pharmacokinetics and relative bioavailability of domestic compound rifampin tablet and imported rifater in Chinese volunteers

    Institute of Scientific and Technical Information of China (English)

    洪诤; 王浴生; 夏培元; 王正荣

    2001-01-01

    本试验对12名男性志愿受试者签署知情同意书,按随机双交叉设计口服国产复方利福平片(华北制药康欣有限公司研制,含利福平120mg,异烟肼80mg,吡嗪酰胺250mg)与相同处方的美国进口rifater片各4片后,定时抽取血样并分别对利福平、异烟肼和吡嗪酰胺的血药浓度和药代动力学参数进行比较.血药浓度用HPLC法检测,用3P87和NDST程序,按非室模型进行药代动力学分析,结果表明,口服国产复方利福平片(又称异福酰胺片)和进口rifater片各4片后,利福平的AUC分别为(73.90±23.41)与(72.84±25.58)mg·h/L,Cmax为(16.7±3.6)与(16.6士3.6)mg/L,Tmax为(1.8士0.3)与(1.8土0.2)h;异烟肼的AUC分别(40.74±16.11)与(43.26±17.99)mg·h/L,Cmax为(9.9±3.4)与(10.0±2.8)mg/L,Tmax为(1.7±0.4)与(1.7±0.4)h;吡嗪酰胺的AUC分别为(499.35士194.35)与(515.69±198.931)mg·h/L,Cmax为(40.4士13.2)与(40.6土12.4)mg/L,Tmax为(1.6±0.4)与(1.6±0.4)h.以进口的rifater片为100%,华北制药康欣有限公司提供的利福平三联片口服后三成分的相对生物利用度:利福平为101.45%-异烟肼为94.17%和吡嗪酰胺为96.83%.结果提示,对结核病患者国产复方利福平片的治疗剂量与疗程可以与进口rifater相同.%ABSTRACT The ingredients of domestic antituberculous compound rifampin tablets (CRFP) were the same as US-made rifater (USRF) which is composed of rifampin (R) 120mg, isoniazid (H) 80mg and pyrazinamide (P) 250mg. Twelve Chinese healthy volunteers [(20.9±1.0)y, (61.9±3.5)kgJ participating in this study after providing informed consent were given a single dose of 4 tablets orally according to a double-cross design. The plasma drug concentrations of each ingredient were measured by HPLC assay individually. The plasma concentration-time curves of them could be well described by an open one compartment model.Results revealed that the pharmacokinetic parameters of R, H, and P in CRFP and USRF were very similar.AUC: R, (73

  8. THE STUDY OF SELF-CONCEPT BETWEEN VOLUNTEER AND NON-VOLUNTEER STUDENTS IN SPORT OF UNIVERSITIES

    Directory of Open Access Journals (Sweden)

    Reza Andam

    2013-03-01

    Full Text Available Understanding personality characteristics of volunteers are important for their recruitment and retention in sport associations. This study compared self-concept as a personality characteristic between volunteer and non-volunteer students in sport associations. The method of this research was survey and descriptive. The statistical population consisted of volunteer and non-volunteer students in sport associations of Iran universities. Two hundred and fifty two students (120 volunteers and 132 non-volunteers from 10 universities were selected as subjects by using random clustered sampling method. Pyryt and Mandaglio Self Perceived Survey (PMSPS was used to collect the data. The content and face reliability of questionnaire was checked and confirmed. Cronbach’s alpha coefficient was used to test the reliability of the questionnaire (alfa=0.90. Independent t test and U Mann-Whitney test were used for comparison of the factors between volunteers and non-volunteers. Findings of this study indicated that there was a significant difference between volunteer and non-volunteer students in social and athletic self-concept. The mean of scientific and value factors were higher in volunteers than non-volunteers, however, they were not statistically significant. We concluded that the nature of sport (active and sport volunteering (social encourage students who have higher self-concept for volunteering. Moreover, the characteristics of sport associations can increase self-concept in sport volunteers.

  9. The relationship between volunteer tourism and development in Thailand

    OpenAIRE

    Kontogeorgopoulos, Nick

    2014-01-01

    Short-term international voluntary service is frequently linked to development discourse in the literature on volunteer tourism and the marketing materials of organizations that offer short-term volunteer opportunities. This paper explores the relationship between volunteer tourism and development in Thailand, and assesses the role played by development in the motivations and experiences of volunteers. Based on interviews with 55 volunteer tourists in the northern Thai province of Chiang Mai,...

  10. Volunteer Computing Experience with ATLAS@Home

    CERN Document Server

    Cameron, David; The ATLAS collaboration; Bourdarios, Claire; Lan\\c con, Eric

    2016-01-01

    ATLAS@Home is a volunteer computing project which allows the public to contribute to computing for the ATLAS experiment through their home or office computers. The project has grown continuously since its creation in mid-2014 and now counts almost 100,000 volunteers. The combined volunteers' resources make up a sizable fraction of overall resources for ATLAS simulation. This paper takes stock of the experience gained so far and describes the next steps in the evolution of the project. These improvements include running natively on Linux to ease the deployment on for example university clusters, using multiple cores inside one job to reduce the memory requirements and running different types of workload such as event generation. In addition to technical details the success of ATLAS@Home as an outreach tool is evaluated.

  11. Volunteer Computing Experience with ATLAS@Home

    CERN Document Server

    Bourdarios, Claire; The ATLAS collaboration; Cameron, David; Filip\\v{c}i\\v{c}, Andrej

    2016-01-01

    ATLAS@Home is a volunteer computing project which allows the public to contribute to computing for the ATLAS experiment through their home or office computers. The project has grown continuously since its creation in mid-2014 and now counts almost 100,000 volunteers. The combined volunteers' resources make up a sizeable fraction of overall resources for ATLAS simulation. This paper takes stock of the experience gained so far and describes the next steps in the evolution of the project. These improvements include running natively on Linux to ease the deployment on for example university clusters, using multiple cores inside one task to reduce the memory requirements and running different types of workload such as event generation. In addition to technical details the success of ATLAS@Home as an outreach tool is evaluated.

  12. Volunteered Cloud Computing for Disaster Management

    Science.gov (United States)

    Evans, J. D.; Hao, W.; Chettri, S. R.

    2014-12-01

    Disaster management relies increasingly on interpreting earth observations and running numerical models; which require significant computing capacity - usually on short notice and at irregular intervals. Peak computing demand during event detection, hazard assessment, or incident response may exceed agency budgets; however some of it can be met through volunteered computing, which distributes subtasks to participating computers via the Internet. This approach has enabled large projects in mathematics, basic science, and climate research to harness the slack computing capacity of thousands of desktop computers. This capacity is likely to diminish as desktops give way to battery-powered mobile devices (laptops, smartphones, tablets) in the consumer market; but as cloud computing becomes commonplace, it may offer significant slack capacity -- if its users are given an easy, trustworthy mechanism for participating. Such a "volunteered cloud computing" mechanism would also offer several advantages over traditional volunteered computing: tasks distributed within a cloud have fewer bandwidth limitations; granular billing mechanisms allow small slices of "interstitial" computing at no marginal cost; and virtual storage volumes allow in-depth, reversible machine reconfiguration. Volunteered cloud computing is especially suitable for "embarrassingly parallel" tasks, including ones requiring large data volumes: examples in disaster management include near-real-time image interpretation, pattern / trend detection, or large model ensembles. In the context of a major disaster, we estimate that cloud users (if suitably informed) might volunteer hundreds to thousands of CPU cores across a large provider such as Amazon Web Services. To explore this potential, we are building a volunteered cloud computing platform and targeting it to a disaster management context. Using a lightweight, fault-tolerant network protocol, this platform helps cloud users join parallel computing projects

  13. Pulsar Discovery by Global Volunteer Computing

    Science.gov (United States)

    Knispel, B.; Allen, B.; Cordes, J. M.; Deneva, J. S.; Anderson, D.; Aulbert, C.; Bhat, N. D. R.; Bock, O.; Bogdanov, S.; Brazier, A.; Camilo, F.; Champion, D. J.; Chatterjee, S.; Crawford, F.; Demorest, P. B.; Fehrmann, H.; Freire, P. C. C.; Gonzalez, M. E.; Hammer, D.; Hessels, J. W. T.; Jenet, F. A.; Kasian, L.; Kaspi, V. M.; Kramer, M.; Lazarus, P.; van Leeuwen, J.; Lorimer, D. R.; Lyne, A. G.; Machenschalk, B.; McLaughlin, M. A.; Messenger, C.; Nice, D. J.; Papa, M. A.; Pletsch, H. J.; Prix, R.; Ransom, S. M.; Siemens, X.; Stairs, I. H.; Stappers, B. W.; Stovall, K.; Venkataraman, A.

    2010-09-01

    Einstein@Home aggregates the computer power of hundreds of thousands of volunteers from 192 countries to mine large data sets. It has now found a 40.8-hertz isolated pulsar in radio survey data from the Arecibo Observatory taken in February 2007. Additional timing observations indicate that this pulsar is likely a disrupted recycled pulsar. PSR J2007+2722’s pulse profile is remarkably wide with emission over almost the entire spin period; the pulsar likely has closely aligned magnetic and spin axes. The massive computing power provided by volunteers should enable many more such discoveries.

  14. Pulsar Discovery by Global Volunteer Computing

    CERN Document Server

    Knispel, B; Cordes, J M; Deneva, J S; Anderson, D; Aulbert, C; Bhat, N D R; Bock, O; Bogdanov, S; Brazier, A; Camilo, F; Champion, D J; Chatterjee, S; Crawford, F; Demorest, P B; Fehrmann, H; Freire, P C C; Gonzalez, M E; Hammer, D; Hessels, J W T; Jenet, F A; Kasian, L; Kaspi, V M; Kramer, M; Lazarus, P; van Leeuwen, J; Lorimer, D R; Machenschalk, A G Lyne B; McLaughlin, M A; Messenger, C; Nice, D J; Papa, M A; Pletsch, H J; Prix, R; Ransom, S M; Siemens, X; Stairs, I H; Stappers, B W; Stovall, K; Venkataraman, A

    2010-01-01

    Einstein@Home aggregates the computer power of hundreds of thousands of volunteers from 192 countries to "mine" large data sets. It has now found a 40.8 Hz isolated pulsar in radio survey data from the Arecibo Observatory taken in February 2007. Additional timing observations indicate that this pulsar is likely a disrupted recycled pulsar. PSR J2007+2722's pulse profile is remarkably wide with emission over almost the entire spin period; the pulsar likely has closely aligned magnetic and spin axes. The massive computing power provided by volunteers should enable many more such discoveries.

  15. Experimental rhinovirus infection in human volunteers exposed to ozone

    Energy Technology Data Exchange (ETDEWEB)

    Henderson, F.W.; Dubovi, E.J.; Harder, S.; Seal, E. Jr.; Graham, D.

    1988-05-01

    We studied 24 young adult male volunteers experimentally inoculated with type 39 rhinovirus to determine whether the course of viral infection was modified by exposure to moderate levels of ozone (0.3 ppm for 6 h per day) over the 5 days after virus inoculation. No differences in rhinovirus titers in nasal secretions, recruitment of neutrophils into nasal secretions, levels of interferon in nasal lavage fluid, in vitro lymphocyte proliferative responses to rhinovirus antigen, or levels of convalescent serum neutralizing antibody to type 39 rhinovirus were demonstrated in relation to ozone exposure. The level and pattern of ozone exposure used in this experiment had no demonstrable adverse effects on the immune responses necessary to limit and terminate rhinovirus infection of the upper respiratory tract.

  16. Comparison of 24-hour urinary citrate excretion in stone formers and healthy volunteers

    Directory of Open Access Journals (Sweden)

    Mohammad Taghi Goodarzi

    2012-01-01

    Full Text Available Low urinary citrate excretion is a risk factor in stone formers (SF. This study aimed to measure the urinary citrate excretion in SF and healthy volunteers at our center from 12 June 2008 to 20 August 2009. There were 28 SF patients (18 males and ten females and 27 (18 males and nine females age-matched healthy adult volunteers who participated in this study. Both groups had a similar living environment, extrinsic factors, diet and genetic descent. After collecting 24-h urine, citrate was measured using an enzymatic kit. Routine urinalysis and 24-h creatinine and uric acid were also performed. There was a significant difference in urinary citrate excretion level among SF (mean 310, SD 260 mg/L and normal volunteer subjects (mean 800, SD 300 mg/L. By applying the previously defined normal values (320 mg/24 h of urinary citrate in the local population, 43% of the SF in our study group was hypocitric, and none among the controls. We conclude that prevalence of hypocitraturia in stone formers was higher than that in healthy volunteers in our population.

  17. BOINC service for volunteer cloud computing

    Science.gov (United States)

    Høimyr, N.; Blomer, J.; Buncic, P.; Giovannozzi, M.; Gonzalez, A.; Harutyunyan, A.; Jones, P. L.; Karneyeu, A.; Marquina, M. A.; Mcintosh, E.; Segal, B.; Skands, P.; Grey, F.; Lombraña González, D.; Zacharov, I.

    2012-12-01

    Since a couple of years, a team at CERN and partners from the Citizen Cyberscience Centre (CCC) have been working on a project that enables general physics simulation programs to run in a virtual machine on volunteer PCs around the world. The project uses the Berkeley Open Infrastructure for Network Computing (BOINC) framework. Based on CERNVM and the job management framework Co-Pilot, this project was made available for public beta-testing in August 2011 with Monte Carlo simulations of LHC physics under the name “LHC@home 2.0” and the BOINC project: “Test4Theory”. At the same time, CERN's efforts on Volunteer Computing for LHC machine studies have been intensified; this project has previously been known as LHC@home, and has been running the “Sixtrack” beam dynamics application for the LHC accelerator, using a classic BOINC framework without virtual machines. CERN-IT has set up a BOINC server cluster, and has provided and supported the BOINC infrastructure for both projects. CERN intends to evolve the setup into a generic BOINC application service that will allow scientists and engineers at CERN to profit from volunteer computing. This paper describes the experience with the two different approaches to volunteer computing as well as the status and outlook of a general BOINC service.

  18. The Benefits of Volunteering for Psychology Students

    Science.gov (United States)

    Bromnick, Rachel; Horowitz, Ava; Shepherd, Daniel

    2012-01-01

    Within the current economic climate students are seen as needing more than a degree to succeed in securing graduate employment. One way that students chose to enhance their employability is through engaging in voluntary work. In this empirical study, undergraduate psychology students' reasons for volunteering are explored within the context of…

  19. International Volunteering: Employability, Leadership and More

    Science.gov (United States)

    Rothwell, Andrew; Charleston, Brandon

    2013-01-01

    Purpose: The purpose of this paper is to investigate the experiences of individuals in transition between education and work during international volunteering expeditions. While it was expected that outcomes might include employability enhancement and skill development, the authors aimed to clarify what the main factors were, examine employability…

  20. Dynamics of Volunteering in Older Europeans

    Science.gov (United States)

    Hank, Karsten; Erlinghagen, Marcel

    2010-01-01

    Purpose: To investigate the dynamics of volunteering in the population aged 50 years or older across 11 Continental European countries. Design and Methods: Using longitudinal data from the first 2 waves of the Survey of Health, Ageing and Retirement in Europe, we run multivariate regressions on a set of binary-dependent variables indicating…

  1. The Invention and Institutionalization of Volunteer Centers

    DEFF Research Database (Denmark)

    Lorentzen, Håkon; Henriksen, Lars Skov

    2014-01-01

    This article presents and explains differences in governmental implementation strategies of volunteer centers in Norway and Denmark. In the first part, we describe the emergence of centers, focusing on shifting policies and governmental initiatives. The second part aims at explaining the observed...

  2. Pulsar discovery by global volunteer computing

    NARCIS (Netherlands)

    Knispel, B.; Allen, B.; Cordes, J.M.; Deneva, J.S.; Anderson, D.; Aulbert, C.; Bhat, N.D.R.; Bock, O.; Bogdanov, S.; Brazier, A.; Camilo, F.; Champion, D.J.; Chatterjee, S.; Crawford, F.; Demorest, P.B.; Fehrmann, H.; Freire, P.C.C.; Gonzalez, M.E.; Hammer, D.; Hessels, J.W.T.; Jenet, F.A.; Kasian, L.; Kaspi, V.M.; Kramer, M.; Lazarus, P.; van Leeuwen, J.; Lorimer, D.R.; Lyne, A.G.; Machenschalk, B.; McLaughlin, M.A.; Messenger, C.; Nice, D.J.; Papa, M.A.; Pletsch, H.J.; Prix, R.; Ransom, S.M.; Siemens, X.; Stairs, I.H.; Stappers, B.W.; Stovall, K.; Venkataraman, A.

    2010-01-01

    Einstein@Home aggregates the computer power of hundreds of thousands of volunteers from 192 countries to mine large data sets. It has now found a 40.8-hertz isolated pulsar in radio survey data from the Arecibo Observatory taken in February 2007. Additional timing observations indicate that this pul

  3. Things Chinese.

    Science.gov (United States)

    Law, Yip Wang

    Presented in this booklet are brief descriptions of items and activities that are symbolic of Chinese culture. Some of the items and activities described include a traditional Chinese child's outfit, dolls, sandalwood fans, writing and printing materials and techniques, toys and crafts, a Chinese abacus, and eating utensils. Several recipes for…

  4. Individual and Social Predictors of Prosocial Behaviour among Chinese Adolescents in Hong Kong

    Directory of Open Access Journals (Sweden)

    Frank H.Y. Lai

    2015-05-01

    Full Text Available Based on the human ecological model, this study hypothesized that individual competence in empathy, prosocial moral reasoning, and social influence from parents, peers, and school are the key determinants of prosocial behaviour among Chinese adolescents in Hong Kong. We recruited a sample of high school students who engaged in volunteering activities regularly (N = 580. They completed a self-administrated questionnaire designed to measure prosocial behaviour and its hypothesized predictors using a number of standardized instruments. The results of multiple regression show that social influence factors, including peer, school, and parent influence, are strong predictors of helping intention and prosocial behaviour, while individual competence factors like empathy and prosocial moral reasoning are not. Male participants had higher empathy scores and helping intention than males, perceived their parents as more helpful, and their schools as more supportive of prosocial behaviour. However, the significant predictors of prosocial behaviour and helping intention were similar across gender. The findings indicate that social influence is strongly linked to prosocial behaviour. This implies that socialization and social support for prosocial norms and behaviour can exert a powerful influence on the behaviour of young people in a Chinese population.

  5. 我国成年男性居民不同身体部位最大力量特征研究%Study on Characteristics of Maximal Muscle Forces of Different Body Parts of Chinese Adult Male Residents

    Institute of Scientific and Technical Information of China (English)

    武东明; 江崇民; 蔡睿

    2015-01-01

    目的:针对我国成年男性不同身体部位最大力量的现状进行相关分析和探究,并探索随年龄的增长最大力量的衰退规律以及日常锻炼习惯与最大力量衰退规律之间的关系。方法:从北京、上海、山东、江苏、江西各选择一个单位抽取相应年龄组人群按照《ACSM 的运动测试与处方指导手册》的测试方法进行上肢、下肢、腰腹部和背部1 RM 测试。结果:普通人群各部位最大绝对力量从大到小依次为:下肢肌肉、背部肌肉、腹部肌肉和上肢肌肉,且各年龄组之间排序相同;上肢、腹部肌肉的相对力量约与自身体重相同,下肢和背部肌肉的相对力量约为自身体重的1.5倍;锻炼习惯对身体各部位最大力量的保持产生积极影响。结论:我国男性居民身体各部位最大力量呈现出随年龄的增长而逐渐下降的趋势,其中有锻炼习惯人群通过日常体育锻炼提高了身体各部位最大肌肉力量基础值,一定程度上掩盖了随年龄增长而产生的身体素质下降趋势;实验数据还反映出身体各部位最大力量下降幅度最大所处的年龄组不尽相同,建议在相应年龄组进行针对性力量训练,通过提高相关部位最大力量的基础值来缓冲因最大力量快速下降而造成的不便。%Objective :Based on the current situation of maximal muscle forces of different body parts of Chinese adult males ,the objective of this study was to make relevant analysis and to explore the law of the decline of maximal forces with the increase of age as well as the correla‐tion between this law and daily exercise habits .Methods :According to ACSMExercise Test and Prescription Instruction Manual ,upper limb ,lower limb ,waist and abdomen and back 1RM tests were carried out on the corresponding age groups of each unit in Beijing ,Shanghai ,Shan‐dong ,Jiangsu and Jiangxi respectively .Results :The maximal

  6. 利用分子标记辅助选育白菜薹复等位基因型雄性不育系%The Directional Transfer of a Multiple-allele Male Sterile Line in Chinese Cabbage by using Molecular Marker-assisted Selection

    Institute of Scientific and Technical Information of China (English)

    王秋实; 刘志勇; 张曦; 冯辉

    2013-01-01

    In order to create an approach for utilization of heterosis in Chinese cabbage (Brassica campestris ssp. chinenesis L.), a breeding method for multiple-allele male sterile line and a“directional transfer program”was designed and carried out in the experiment. A multiple-allele male sterile line of Chinese cabbage“Wangzi”was used as a resource of male sterility, and an inbred line of Chinese cabbage was the target line. Recurrent backcr-ossing method was employed to transfer male sterility and horticultural characters while the genotype was iden-tified through molecular marker-assisted selection. The GSSR1, which is closely linked to the male sterility gene“Ms”, was chosen from 26 pairs of SSR primers to apply in the selection. GSSR1 also could select the fertile gene“ms”and the fertile restoration gene“Msf”. After three times recurrent backcrossing, a new genetic male sterile line of Chinese cabbage with 100%of male sterile plants and 100%of male sterility, BGMS-3, was bred. The new male sterile line was applied to develop hybrid combinations, and then one excellent combination of C3 was selected from six combinations.%为解决白菜薹杂种优势利用中的杂交制种手段问题,以大白菜复等位基因型雄性不育系为不育源,设计定向转育方案,采用连续回交的方法转育不育性和农艺性状,同时利用分子标记辅助选择目标基因型植株,向白菜薹自交系中转育不育基因,创制白菜薹雄性不育系。通过26对SSR引物的筛选鉴定,获得与显性雄性不育基因Ms紧密连锁、且同样可以标记同一位点恢复基因Msf和可育基因ms的分子标记GSSR1。经过3个世代的回交转育,创制出了具有100%不育度和100%不育株率的白菜薹复等位基因型雄性不育系BGMS-3。以BGMS-3为母本,与6个白菜薹自交系杂交,筛选出1个强优势组合C3。

  7. Who will volunteer? Analysing individual and structural factors of volunteering in Swiss sports clubs.

    Science.gov (United States)

    Schlesinger, Torsten; Nagel, Siegfried

    2013-01-01

    This article analyses the conditions influencing volunteering in sports clubs. It focuses not only on individual characteristics of volunteers but also on the corresponding structural conditions of sports clubs. It proposes a model of voluntary work in sports clubs based on economic behaviour theory. The influences of both the individual and context levels on the decision to engage in voluntary work are estimated in different multilevel models. Results of these multilevel analyses indicate that volunteering is not just an outcome of individual characteristics such as lower workloads, higher income, children belonging to the sports club, longer club memberships, or a strong commitment to the club. It is also influenced by club-specific structural conditions; volunteering is more probable in rural sports clubs whereas growth-oriented goals in clubs have a destabilising effect.

  8. CAG-repeat variant in the polymerase γ gene and male infertility in the Chinese population: a meta-analysis%DNA聚合酶γ基CAG-三核苷酸多态性与中国人群男性不育的相关性研究及元分析

    Institute of Scientific and Technical Information of China (English)

    Shu-Yuan Liu; Xiao-Qin Huang; Hao Sun; Jia-You Chu; Chang-Jun Zhang; Hai-Ying Peng; Yu-Feng Yao; Lei Shi; Jin-Bao Chen; Ke-Qin Lin; Liang Yu; Li Shi

    2011-01-01

    Several studies have reported a relationship between the length of the CAG-repeat in the polymerase γ(POLG)gene and male infertility.However,other studies have not reproduced this result.In our study,the POLG-CAG-repeat length was analyzed in 535 healthy individuals from six Chinese Han populations living in different provinces.The frequencies of 10-CAG alleles and genotypes were high(97.38 and 94.13%,respectively),with no significant difference among the six Chinese Han populations.Furthermore,we determined the distribution of the POLG-CAG-repeat in 150 infertile men and 126 fertile men.Our study suggested that the distributions of POLG-CAG-repeat alleles and genotypes were not significantly different between infertile(95.67 and 92.67%,respectively)and fertile men(97.22 and 94.44%,respectively).In a subsequent meta-analysis,combining our data with data from previous studies,a comparison of the CAG-repeat alleles in fertile versus infertile men showed no obvious risk for male infertility associated with any particular allele(pooled odds ratio(OR)=0.94; 95% confidence interval(CI):0.60-1.48).The significance level was not attained with any of the following genetic models: homozygote comparison(not 10/not 10 versus 10/10:OR=1.34; 95% CI:0.66-2.72),heterozygote comparison(10/not 10 versus 10/10: OR=1.04; 95% CI:0.78-1.38),dominant model comparison(not 10/not 10+10/not 10 versus 10/10: OR=1.08; 95% CI: 0.79-1.47)and recessive genetic comparison(not 10/not 10 versus 10/not 10+10/10:OR=1.31; 95% CI:0.68-2.55).In conclusion,there is no significant difference of the frequencies of POLG-CAG.repeat variants among six Chinese Han populations,and this polymorphism may not be associated with Chinese male infertility.On the basis of a meta-analysis,there is no obvious association between CAG-repeat variants of the POLG gene and male infertility.

  9. Stress and Burnout: Concerns for the Hospice Volunteer.

    Science.gov (United States)

    Glass, J. Conrad, Jr.; Hastings, Janice L.

    1992-01-01

    Sources of stress for hospice volunteers are environmental, ideological, and personal. Attention to volunteer stress and burnout involves defining job requirements and responsibilities, frequent communication and feedback, stress management techniques, flexibility in assignments, and opportunities to verbalize emotions. (SK)

  10. Long-term dietary supplementation with a yang-invigorating Chinese herbal formula increases lifespan and mitigates age-associated declines in mitochondrial antioxidant status and functional ability of various tissues in male and female C57BL/6J mice.

    Science.gov (United States)

    Ko, Kam Ming; Chiu, Po Yee; Leung, Hoi Yan; Siu, Ada Hoi Ling; Chen, Na; Leong, Eriol Pou Kwan; Poon, Michel K T

    2010-01-01

    To investigate whether Vigconic 28 (VI-28), a Yang-invigorating Chinese herbal formula, could affect survival of aging animals, male and female C57BL/6J mice were given a VI-28-supplemented diet (0.05 and 0.5%, wt/wt) starting at 36 weeks of age, until death. VI-28 dietary supplementation at 0.05% significantly increased median lifespans of both male and female mice as compared to controls. Survival enhancement was associated with protection against age-associated impairments in mitochondrial antioxidant status and functional ability in various tissues. In conclusion, VI-28 could retard the aging process in mice, probably by mitigating age-associated declines in mitochondrial antioxidant status and functional ability in tissues.

  11. [Features of emotional stability in volunteers of gerontology programs].

    Science.gov (United States)

    Dolgova, V I

    2014-01-01

    The paper presents an analysis of the characteristics of emotional stability in volunteers of gerontology programs (among the students of the Faculty of Psychology), depending on the structure of their life meaning and values, personal factors and professional important qualities. It is shown that the emotional stability of volunteers determines the main directions to explore the potential of the psyche of volunteers; modeling appropriate professiogram; organization of volunteer work in a particular program.

  12. Molecular helpers wanted... Call for volunteers!

    CERN Document Server

    2008-01-01

    The Task Force in charge of the organization of the LHC Inauguration is looking for 40 volunteers to support the team of molecular cooks directed by international chef Ettore Bocchia. The "molecular" volunteers will help in the preparation of liquid nitrogen ice-cream. Your help is requested from 12h to 18h on October 21st. Your participation in a general rehearsal on October 20th is also required - (the time of the rehearsal will be communicated at a later moment). Dress code: black pants and shoes, long sleeved white shirt. Do not miss this opportunity to take part in an extraordinary event! For further information and to enrol, contact: mailto:Catherine.Brandt@cern.ch

  13. The volunteer programme ‘Night Ravens’:

    DEFF Research Database (Denmark)

    Larsen, Britt Østergaard; Bendix Kleif, Helle; Kolodziejczyk, Christophe

    2015-01-01

    are based on a longitudinal data set containing socio-demographic information on all 585 postcode districts in Denmark and quarterly records of six different categories of reported crimes in the years 2001–2010.We apply a difference-in-difference design and compare development in crime rates in districts...... with NR organizations to districts without NR organizations. The results show no difference in the crime rates between Danish postcode districts with and without the NR programme. Hence, we cannot identify positive effects of situational crime prevention when evaluating this Scandinavian volunteer......The volunteer programme ‘Night Ravens’ (NR) was founded in Sweden in 1987 and has, over the years, developed into a Scandinavian concept covering large areas of Sweden, Denmark, Norway, Greenland and the Faroe Islands. The NR programme is a crime prevention initiative with adults walking...

  14. 中国男性青年军人对同性恋者及其服兵役的态度%Attitudes of Chinese young male military personnel toward homosexuality in the army

    Institute of Scientific and Technical Information of China (English)

    阎同军; 王焕林; 王彦彦; 毕银花

    2009-01-01

    目的 评价中国男性青年军人对同性恋者及同性恋者服兵役的态度.方法 随机整群抽取1368名南京军区陆军某部现役男性青年军人,采用军人对男/女同性恋者的态度量表(ATLG)(中文版)及军人对军队中的同性恋者的态度量表(ATHM)(中文版)进行测最,并对其结果进行统计分析.结果 ATLG量表最低分22,最高分80,平均(45.59±7.90)分;ATHM量表最低分14,最高分为53,平均(29.43±6.56)分;中国男性青年军人对男、女同性恋者均持否定的态度,尤其对男同性恋者更加反感(t=7.212,P=0.000);未发现ATLG量表、ATHM量表评分与年龄、军龄、职别、是否独生子女及受教育程度存在相关;ATLG评分与ATHM评分间存在正相关(r=0.491,P<0.01).结论 中国当代军人对同性恋者服役的态度既表示轻度支持,存在较高的宽容度,同时又感到与同性恋者在一起"不舒服",且这种反感多表现在道德及社会舆论范畴.%Objective To assess attitudes of Chinese young male military personnel with regard to homosexuality and homosexuality served in the army. Methods 1368 enlisted military personnel from Nanjing Military Region chosen hy random cluster sampling were tested and analyzed by Military Personnel' s Attitudes Toward Lesbian and Gay men Scale ( ATLG) and Military Personnel' s Attitudes Toward Homosexuals in the Military Scale (ATHM). Results The summed scores on the ATLG scale ranged from 22 to 80 (45. 59 ± 7. 90) , and the summed scores on the ATHM scale ranged from 14 to 53 (29.43 ± 6. 56). Attitudes of the present sample toward lesbians and gay men in general were found to be negative, especially toward gay men(t = 7.212, P = 0.000). There was no relation found between scale scores and the demographic variables such as age, length of military service, official rank, education , while the Pearson correlation coefficients between ATLG scores and ATHM scores was high(r=0.491, P<0.01). Conclusion Attitudes toward

  15. Correlation between Seasonal Changes in Territory Behavior and Fecal Testosterone Level in Captive Male Chinese Water Deer (Hydropotes inermis)%圈养雄獐领域行为和粪便睾酮水平变化的关系

    Institute of Scientific and Technical Information of China (English)

    余晓俊; 陈珉; 张恩迪; 张志明; 叶建华; 裴恩乐; 袁晓

    2013-01-01

    By the method of focal sampling, instantaneous scan sampling and all-occurrence recoding, we observed six territory behaviors, included fighting, threatening, displacing, chasing, forehead scrap-marking and defecating-marking, of 6 captive male Chinese Water Deer (Hydropotes inermis) from August 2011 to April 2012 in the Huaxia Park of Pudong, Shanghai. The fecal testosterones were analyzed by radio-immunoassays to investigate the correlation between hormone and territory behaviors. The results indicated that there were significant differences in fighting, threatening, displacing, chasing, and defecating-marking among months (P< 0. 05, one-way ANOVA analysis). The deer spent significantly more time on all of the six behaviors in November. There were significant differences in fighting, threatening, forehead scrap-marking and defecating-marking between estrus ( from October 2011 to January 2012) and non-estrus ( September 2011 , from February 2012 to April 2012) ( P < 0. 05, Independent samples T test) . The deer spent significantly more time on all of the six behaviors in estrus. In estrus, the fecal testosterone concentration level increased obviously than in non-estrus, and it reached the highest level in December (51. 16 ±9. 85 ng/g). The fecal testosterone levels were closely correlated with threatening, forehead scrap-marking, defecating-marking and fighting.%2011年8月到2012年4月间,在上海市浦东新区华夏公园獐重引入试点,采用目标取样、扫描取样和全事件记录法,对圈养条件下6只成体雄獐(Hydropotes inermis)的6种领域行为进行观察,并利用放射免疫分析法(RIA)测定雄獐粪便中的睾酮水平变化.结果表明,雄獐的许多领域行为发生频次表现出明显的月间变化,包括打斗、威胁、取代、追逐和粪尿标记;擦额标记行为频次虽月间差异不显著,但与其他领域行为一样在11月份出现频次峰值.发情期(2011年10月~2012年1月)和非发情期(2011

  16. 非洛地平缓释片在中国健康男性的生物等效性%Bioequivalence of felodipine extended release tablets in Chinese healthy male subjects

    Institute of Scientific and Technical Information of China (English)

    许俊羽; 赵侠; 孙严彤; 顾景凯; 王梓凝; 张冬梅; 周颖; 梁雁; 崔一民

    2013-01-01

    目的 评价2种非洛地平缓释片在健康中国男性人体的生物等效性.方法 用双交叉设计,24名健康男性受试者随机分为2组,单剂量口服非洛地平缓释片试验药物或对照药物5mg,用液相色谱-串联质谱法测定血浆非洛地平血药浓度,用DAS 2.0软件计算药代动力学参数.结果 试验药物与对照药物的Cmax分别为(2.15±1.37),(1.67±0.87) ng·mL-1;Tmax分别为(5.40±3.42),(5.85±4.84)h;t1/2分别为(16.51±5.82),(18.78±8.16)h;AUCo-72h分别为(37.68±22.05),(34.71±20.88)ng·h·mL-1;AUCo-∞分别为(39.90±23.64),(37.93±23.75)ng·h·mL-1;Cmax、AUCo-r2h和AUCo-∞的90%可信区间分别为109.6% ~ 141.6%,99.2% ~120.2%和96.2% ~117.8%.两制剂的Tmax非参数法检验差异无统计学意义.试验药物对于对照药物的平均相对生物利用度F为(114.0±33.7)%.结论 2种非洛地平缓释片剂在中国健康男性受试者体内具有生物等效性.%Objective To evaluate the bioequivalence of the two felo-dipine extended release tablets in Chinese healthy male subjects. Methods A single oral dose 5 mg of test and reference felodipine extended release tablets were given to 24 subjects according to an open randomized crossover design. The concentrations of felodipine in plasma were determined by LC - MS/MS. The pharmacokinetic parameters were calculated and the bioequivalence was compared by DAS 2. 0. Results The main pharmacokinetic parameters of felodipine of the test and reference preparations were as follows:Cmax were (2. 15 ± 1. 37) and (1. 67 ±0. 87) ng · mL-1; Tmax were (5. 40 ±3.42), (5. 85 ±4. 84) h; t1/2 were (16. 51 ±5.82) and (18.78 ±8. 16) h; AUC0-72hwere (37.68 ±22.05) and (34.71 ±20.88) ng · H · mL-1; AUC0_. Were (39. 90 ± 23. 64) and (37. 93 ±23. 75) ng · H · mL-1. The 90% confidential interval of Cmax, AUC0-72h and AUC0_∞ of tested formulation were 109. 6% ~ 141. 6% , 99. 2% ~ 120. 2 % and 96. 2% ~ 117. 8% . There was no

  17. Religion, Inclusive Individualism, and Volunteering in Europe

    OpenAIRE

    Storm, Ingrid

    2015-01-01

    A well supported finding in social science is that religiosity is associated with pro-social behaviours such as volunteering, but the religious decline in Europe characterising the latter part of the twentieth century has not been accompanied by decline in voluntary participation. This period is also associated with a sharp increase in the moral emphasis on individual autonomy and inclusiveness over social norms and traditions. In this analysis of the European Values Study (2008–2010), I exam...

  18. Will Natural Resources Professionals Volunteer to Teach Youth?

    Science.gov (United States)

    Smith, Sanford S.; Finley, James C.; San Julian, Gary J.

    2010-01-01

    A unique approach to volunteer marketing research involved a mail survey with natural resources professionals from across Pennsylvania. Previous work identified this group as a source of potential volunteers for the 4-H youth natural resources program. The results give insights into those most likely to volunteer to teach youth through 4-H…

  19. The impact of volunteering in hospice palliative care.

    Science.gov (United States)

    Claxton-Oldfield, Stephen; Claxton-Oldfield, Jane

    2007-01-01

    The goal of this study was to examine the impact of hospice palliative care work on volunteers' lives. In-depth interviews were conducted with 23 direct-patient care volunteers. More than half of the volunteers became involved in hospice palliative care because of their own experiences with family members and/or friends who have died. Most of the volunteers reported that they were different now or had changed in some way since they have been volunteering (e.g., they had grown in some way, have learned how to keep things in perspective). In addition, most of the volunteers felt that their outlook on life had changed since they started volunteering (e.g., they were more accepting of death, and they learned the importance of living one day at a time). Volunteers reported doing a number of different things to prevent compassion fatigue or burnout (e.g., reading a book, listening to music, talking to others, and taking time off from volunteering). Most of the volunteers said that they would tell anyone who might be thinking of volunteering in hospice palliative care that it is a very rewarding activity and/or that they should try it. Finally, many of the volunteers offered suggestions for doing things differently in their programs.

  20. The Impact of Various Personal and Social Characteristics on Volunteering.

    Science.gov (United States)

    Hughes, Philip; Black, Alan

    2002-01-01

    Analysis of Australian Community Survey data (n=6,242) identified three categories of volunteer involvement: assisting those who need help, serving the wider community, and being involved in volunteer groups. Volunteers in each category had different characteristics. Key influences were having resources to contribute, existence of recruitment…

  1. Motivations of Volunteer Leaders in an Extension Exercise Program

    Science.gov (United States)

    Washburn, Lisa T.; Cornell, Carol E.; Traywick, LaVona; Felix, Holly C.; Phillips, Martha

    2015-01-01

    This article describes findings from a qualitative study of volunteer leaders in the StrongWomen strength training program in Arkansas. The study explored reasons volunteers initially agreed to serve, perceptions of volunteer role, and motivations for continuing to lead strength training groups long-term. Findings suggest a combination of factors…

  2. Assessing Changes in Virginia Master Gardener Volunteer Management

    OpenAIRE

    Dorn, Sheri T.

    1999-01-01

    ASSESSING CHANGES IN VIRGINIA MASTER GARDENER VOLUNTEER MANAGEMENT Sheri T. Dorn ABSTRACT Master Gardener (MG) volunteers are nonpaid, education partners with Virginia Cooperative Extension (VCE). VCE MGs have assisted Extension agents in meeting VCE's educational goals and mission by following the Sustainable Landscape Management educational program objectives within the VCE Plan of Work. Local MG volunteer programs must be managed appropriately so that vol...

  3. Classroom Volunteers: Uh-Oh! or Right On!

    Science.gov (United States)

    Wachter, Joanne C.

    Noting that volunteer programs succeed only with careful forethought and maintenance, this book is designed to provide information necessary to create and operate a successful volunteer program in an elementary school setting. Steps in thinking about volunteers in innovative ways, recruitment, training, maintaining program effectiveness, and…

  4. Canadian Youth Volunteering Abroad: Rethinking Issues of Power and Privilege

    Science.gov (United States)

    Ngo, Mai

    2013-01-01

    This paper discusses the role of institutions in the ethical engagement of Canadian youth volunteers abroad. In recent years, researchers and practitioners in the international field have questioned the ethics of volunteering as part of development, with scrutiny on who actually benefits from volunteering initiatives. Since the 1960s, over 65,000…

  5. An Evaluation of the Use of Volunteers as Parent Educators.

    Science.gov (United States)

    Ganong, Lawrence H.; Coleman, Marilyn

    1983-01-01

    Assessed the effectiveness of trained volunteers in leading parent education programs. Compared volunteer and professionally led groups in an ongoing extension-sponsored parenting program. Urban/rural comparisons were also made. There were no significant differences between volunteer and professionally led groups on child gains or parent…

  6. The Motivation to Volunteer: A Systemic Quality of Life Theory

    Science.gov (United States)

    Shye, Samuel

    2010-01-01

    A new approach to volunteer motivation research is developed. Instead of asking what motivates the volunteer (accepting "any" conceptual category), we ask to what extent volunteering rewards the individual with each benefit taken from a complete set of possible benefits. As a "complete set of benefits" we use the 16 human functioning modes…

  7. ATLAS@Home looks for CERN volunteers

    CERN Multimedia

    Rosaria Marraffino

    2014-01-01

    ATLAS@Home is a CERN volunteer computing project that runs simulated ATLAS events. As the project ramps up, the project team is looking for CERN volunteers to test the system before planning a bigger promotion for the public.   The ATLAS@home outreach website. ATLAS@Home is a large-scale research project that runs ATLAS experiment simulation software inside virtual machines hosted by volunteer computers. “People from all over the world offer up their computers’ idle time to run simulation programmes to help physicists extract information from the large amount of data collected by the detector,” explains Claire Adam Bourdarios of the ATLAS@Home project. “The ATLAS@Home project aims to extrapolate the Standard Model at a higher energy and explore what new physics may look like. Everything we’re currently running is preparation for next year's run.” ATLAS@Home became an official BOINC (Berkeley Open Infrastructure for Network ...

  8. Pharmacokinetics of diltiazem hydrochloride delay-onset sustained-release pellet capsules in healthy volunteers

    Directory of Open Access Journals (Sweden)

    Xi-Qing Yan

    2013-03-01

    Full Text Available The pharmacokinetics (PK of ordinary tablets and sustained release capsules of diltiazem hydrochloride in human clinical trials had been studied. The PK of diltiazem hydrochloride delay-onset sustained-release pellet capsules, a new dosage form, has not been reported, although it is very important to clinical use. In this paper, we investigated the PK of diltiazem hydrochloride delay-onset sustained-release pellet capsules and the food influence in Chinese healthy volunteers. The PK parameters indicated that the diltiazem hydrochloride delay-onset sustained-release pellet capsules appeared marked characteristics of delayed and controlled release. An opened-label, randomized and parallel clinical trial was conducted in 36 Chinese healthy volunteers with single oral dose (90 mg, 180 mg or 270 mg and a multiple oral dose (90 mg d-1×6 d administration. The effect of food on the PK of one single oral dose (360 mg was investigated in 24 healthy Chinese volunteers. Plasma diltiazem concentration was determined by reversed-phase high-performance liquid chromatography (RP-HPLC and the main pharmacokinetic parameters were analyzed by PKSolver (Ver 2.0. All clinical studies were conducted in the Clinical Pharmacological Center (No. JDX1999064 of Xiangya Hospital Affiliated Central South University, China. The PK parameters suggested that the new formulation had marked characteristics of delayed and controlled release of diltiazem, and food intake did not alter significantly diltiazem pharmacokinetic parameters.Embora a farmacocinética (PK do cloridrato de diltiazem nas formas de comprimidos de liberação imediata e cápsulas de liberação modificada em ensaios clínicos já tenha sido relatada, a pesquisa da PK do cloridrato de diltiazem na forma de cápsulas com peletes de liberação retardada e sustentada ainda é muito importante. Neste trabalho, propusemos avaliar a farmacocinética do cloridrato de diltiazem administrado através desta nova forma

  9. Exercise increases endostatin in circulation of healthy volunteers

    Directory of Open Access Journals (Sweden)

    Makey Ian

    2004-01-01

    Full Text Available Abstract Background Physical inactivity increases the risk of atherosclerosis. However, the molecular mechanisms of this relation are poorly understood. A recent report indicates that endostatin, an endogenous angiostatic factor, inhibits the progression of atherosclerosis, and suggests that reducing intimal and atherosclerotic plaque tissue neovascularization can inhibit the progression atherosclerosis in animal models. We hypothesize that exercise can elevate the circulatory endostatin level. Hence, exercise can protect against one of the mechanisms of atherosclerosis. Results We examined treadmill exercise tests in healthy volunteers to determine the effect of exercise on plasma levels of endostatin and other angiogenic regulators. Oxygen consumption (VO2 was calculated. Plasma levels of endostatin, vascular endothelial growth factor (VEGF, and basic fibroblast growth factor (bFGF were determined using ELISA. The total peak VO2 (L in 7 male subjects was 29.5 ± 17.8 over a 4–10 minute interval of exercise. Basal plasma levels of endostatin (immediately before exercise were 20.3 ± 3.2 pg/ml, the plasma levels increased to 29.3 ± 4.2, 35.2 ± 1.8, and 27.1 ± 2.2 ng/ml, at 0.5, 2, and 6 h, respectively, after exercise. There was a strong linear correlation between increased plasma levels of endostatin (% and the total peak VO2 (L related to exercise (R2 = 0.9388; P Conclusions The results suggest that circulating endostatin can be significantly increased by exercise in proportion to the peak oxygen consumption under physiological conditions in healthy volunteers. These findings may provide new insights into the molecular links between physical inactivity and the risk of angiogenesis dependent diseases such as atherosclerosis.

  10. Clinical Trials in Male Hormonal Contraception

    Directory of Open Access Journals (Sweden)

    Nieschlag E

    2011-01-01

    Full Text Available Research has established the principle of hormonal male contraception based on suppression of gonadotropins and spermatogenesis. All hormonal male contraceptives use testosterone, but only in East Asian men can testosterone alone suppress spermatogenesis to a level compatible with contraceptive protection. In Caucasians, additional agents are required of which progestins are favored. Clinical trials concentrate on testosterone combined with norethisterone, desogestrel, etonogestrel or depot-medroxyprogesterone acetate. The first randomized, placebo-controlled clinical trial performed by the pharmaceutical industry demonstrated the effectiveness of a combination of testosterone undecanoate and etonogestrel in suppressing spermatogenesis in volunteers.

  11. Determination of Mirtazapine in Human Plasma by HPLC-MS and Bioavailability of Newly Developed Mirtazapine Tablets in Healthy Volunteers

    Institute of Scientific and Technical Information of China (English)

    LIRong-shan; DINGLi; JIANLong-hai; XIAOHong

    2004-01-01

    Aim To estabhsh a sensitive and specific liquid chromatography-mass spectrometry method for determination of mirtazapine in human plasma and evaluation of its relative bioavailabihty. Methods After being alkalized by 25% ammonia, mirtazapine in the plasma was extracted with n-hexane. Desloratadine was used as internal standard (IS). Solutes were separated on a C18 column with a mobile phase of methanol-ammonium acetate buffer (pH3.5) (75:25). The flow rate of the mobile phase was 1 mL·min-1. Detection was performed on an electrospray ionization (ESI) mass spectrometer and operated in selected ion monitoring (SIM) and positive-ionization mode using target ionsat m/z 266.2 for mirtazapine and m/z 311.2 for the IS. The fragmentor voltage was 90 V. A randomized cross-over study was performed in 20 healthy volunteers. In the two study periods, twenty healthy Chinese male subjects received a single oral dose of mirtazapine 30 mg. Results The calibration curve was linear over the range of 0.3-200 ng·mL-1. The limit of quantitation was 0.1 ng·mL-1. The paramneters for mirtazapine test tablet and reference tablet were as follows.. T1/2 ( 24.7±4.1 ) and (23.6±4.3) h, Tmax (1.6±0.8) and (1.5±0.8) h, Cmax (95.9±29.8) and (91.9±26.7) ng·mL-1, respectively. Conclusion The estabhshed HPLC-MS method is rapid, sensitive and specific for the detemtination of mirtazapine in human plasma. The relative bioavailability was 100.0%±10.8%.

  12. Safety Evaluation of Crocin (a constituent of saffron Tablets in Healthy Volunteers

    Directory of Open Access Journals (Sweden)

    Amir Houshang Mohamadpour

    2013-01-01

    Full Text Available Objective(s: Crocin is the chemical ingredient primarily responsible for the color of saffron. It has different pharmacological effects such as antioxidant, anticancer and memory improving activities. Crocin tablets were evaluated for short-term safety and tolerability in healthy adult volunteers. Materials and Methods: The study was a randomized, double-blind, placebo-controlled design consisting of one month treatment of crocin tablets. Volunteers who fulfilled inclusion and exclusion criteria were randomized into 2 groups of 22 each (males and females and received 20 mg crocin tablets or placebo. General measures of health were recorded during the study such as hematological, biochemical, hormonal and urinary parameters in pre and post-treatment periods. Results: No major adverse events were reported during the trial. Crocin tablets did not change the above parameters except that it decreased amylase, mixed white blood cells and PTT in healthy volunteers after one month. Conclusion: This clinical safety evaluation showed a relatively safe and normal profile for crocin in healthy volunteers at the given doses within the trial period.

  13. The stingy hour: how accounting for time affects volunteering.

    Science.gov (United States)

    DeVoe, Sanford E; Pfeffer, Jeffrey

    2010-04-01

    These studies examined how the practice of accounting for one's time-so that work can be billed or charged to specific clients or projects-affects the decision to allocate time to volunteer activities. Using longitudinal data collected from law students transitioning to their first jobs, Study 1 showed that exposure to billing time diminished individuals' willingness to volunteer, even after controlling for attitudes about volunteering held before entering the workforce as well as the individual's specific opportunity costs of volunteering time. Studies 2-5 experimentally manipulated billing time and confirmed its causal effect on individuals' willingness to volunteer and actual volunteering behavior. Study 5 showed that the effect of exposure to billing time on volunteering occurred above and beyond any effects on general self-efficacy or self-determination. Individual differences moderated the effects of billing, such that people who did not value money as much were less affected.

  14. Widely Assumed but Thinly Tested: Do Employee Volunteers' Self-Reported Skill Improvements Reflect the Nature of Their Volunteering Experiences?

    Science.gov (United States)

    Jones, David A

    2016-01-01

    An increasing number of companies use corporate volunteering programs (CVPs) to support and coordinate their employees' efforts to serve their communities. Among the most frequently touted benefits of such programs to sponsoring companies and employee volunteers alike is the opportunities for employees to develop tangible work-related skills through their volunteering activities. Evidence for skill development through volunteering, however, is mostly limited to the expressed beliefs of corporate leaders and employee volunteers. This study was designed to contribute to this largely anecdotal literature by testing hypotheses about the extent to which employee volunteers' self-reported skill development reflects the characteristics of the volunteers and their volunteering experiences. Study participants were 74 employee volunteers who completed a service apprenticeship managed by a U.S.-based nonprofit called Citizen Schools that partners with middle schools to extend the learning day with a combination of academic support, enrichment, and youth development activities. Data were obtained via the nonprofit's records, and surveys completed by employee volunteers before and after their service experience, including measures used to assess self-reported improvements in each of 10 work-related skills: communicating performance expectations, leadership, mentorship, motivating others, project management, providing performance feedback, public speaking and presenting, speaking clearly, teamwork, and time management. Support was found for several hypothesized effects suggesting that employees who practiced specific skills more often during their volunteering experience reported greater improvements in those skills. Improvements in some skills were higher among employee volunteers who completed a greater number of pre-volunteering preparation courses, and the effects of preparation courses were moderated by the employee volunteers' self-efficacy about improving their work

  15. Dietary Supplement with a Combination of Rhodiola Crenulata and Ginkgo Biloba Enhances the Endurance Performance in Healthy Volunteers

    Institute of Scientific and Technical Information of China (English)

    张樟进; 童瑶; 邹军; 陈佩杰; 虞定海

    2009-01-01

    Objective:To determine whether the ingestion of a herbal supplement called Rhodiola-Gingko Capsule(RGC) would enhance the endurance performance of healthy volunteers and change relevant hormones in a favorable manner.Methods:Seventy healthy male volunteers(age ranges from 18 to 22 years old) were randomly assigned to RGC group(35 cases,each capsule containing 270 mg herbal extracts,4 capsules per day) or placebo group(35 cases,equivalent placebo preparation) for 7 weeks using computerproduced digital ran...

  16. 不结球白菜雄性不育系及其保持系花药发育的细胞学观察%Cytological Observation of Anther Development between the Male Sterile Line and Its Maintainer Line in Non-heading Chinese Cabbage

    Institute of Scientific and Technical Information of China (English)

    朱红芳; 侯瑞贤; 李晓锋; 朱玉英; 侯喜林

    2011-01-01

    以不结球白菜(Brassica campestris ssp.chinensis Makino)雄性不育系及其保持系为试验材料,选择不同发育阶段的花蕾,取其花药,制成石蜡切片和超薄切片,经染色后在电子显微镜下观察.结果表明,不结球白菜雄性不育系与保持系的花药发育有明显的不同:不育系花药发育受阻于花粉母细胞分化期,形成1~3个药室,并形成正常的四分体小孢子,此时细胞组织逐步解体,形成空腔花药;最后向内皱缩;保持系花粉母细胞能形成正常的四分体,进而形成小孢子,最终形成充满正常花粉粒的花药.%Buds selected at different developmental stages of a new germplasm sterile male of non-heading Chinese cabbage and its maintainer lines were studied. Anthers were collected,made into paraffin sections, stained, and observed by electron microscopy. Results show that non-heading Chinese cabbage sterile male lines and maintainer lines exhibited quite different anther development. Male sterile lines in relation to anther development were inhibited at the stage of archesporial cell, produced only 1 -3 anther sacs, and formed normal sporogenous cells. The cells gradually disintegrated,formated cavity,and finally shrunk inward. The maintainer archesporial cells formed normal anther sacs, formed sporogenous cell, and ultimately formed anthers with normal pollen.

  17. Volunteering as a means to an equal end? The impact of a social justice function on intention to volunteer.

    Science.gov (United States)

    Jiranek, Patrick; Kals, Elisabeth; Humm, Julia Sophia; Strubel, Isabel Theresia; Wehner, Theo

    2013-01-01

    In the present study, we combined components of the theory of planned behavior and the functional approach to predict the social sector volunteering intention of nonvolunteers (N = 513). Moreover, we added a new other-oriented "social justice function" to the Volunteer Functions Inventory of Clary and colleagues (1998), which contains mainly self-oriented functions. We distinguished the social justice function from the other five measured volunteer functions in confirmatory factor analysis, and showed its incremental validity in predicting intention to volunteer beyond established constructs such as self-efficacy, subjective norm, and the five volunteer functions. This study suggests that emphasizing potential social justice improvements by means of volunteering may attract new volunteers.

  18. Stereoselective disposition of flurbiprofen in normal volunteers.

    OpenAIRE

    Knadler, M P; Brater, D C; Hall, S. D.

    1992-01-01

    1. The concentrations of the R- and S-enantiomers of flurbiprofen and its metabolites were measured in plasma and urine following the oral administration of 50 mg racemic flurbiprofen to six normal volunteers. 2. The AUC and half-life of the R-enantiomer were significantly lower than the corresponding S-enantiomer values reflecting the greater clearance of R-flurbiprofen (20.42 +/- 4.71 vs 16.12 +/- 3.60 ml min-1). 3. Ex vivo protein binding studies indicated that the percent unbound of R-flu...

  19. Male Osteoporosis

    Directory of Open Access Journals (Sweden)

    Meltem Esenyel

    2004-03-01

    Full Text Available Osteoporosis in men is now recognized as an increasingly important public health issue. About 30 % of hip fractures and 20 % of vertebral fractures occur in men. In the present study, we examined 19 men who did not have major risk factors that might affect bone mass. Parathormone(PTH, osteocalcin (marker of bone formation, OC and deoxypyridinoline (marker of bone resorption, DPD were measured. The bone mineral density (BMD measurements in 16 men were performed by dual-energy X-ray absorbtiometry (DXA from lumbar spine (L2-4, and left hip. Bone density at each site was categorized as osteoporosis or osteopenia according to World Health Organization (WHO criteria. In 19 patients with a mean age of 69 years, PTH levels were in the normal range except one patient. OC levels were elevated in %42.1 and DPD levels were elevated in 74 % of patients. L2-4 T score was osteoporotic (25% in 4 patients and osteopenic (25% in 4 patients. Femur Ward’s T score was osteoporotic (37.5% in 7 patients and osteopenic (37.5% in 7 patients. Osteoporosis is a significant problem in older men. Increased awareness for the risk factors of male osteoporosis is an important issue. Early diagnosis and treatment would help to reduce morbidity and mortality resulting from osteoporotic fractures.

  20. Uses and biases of volunteer water quality data

    Science.gov (United States)

    Loperfido, J.V.; Beyer, P.; Just, C.L.; Schnoor, J.L.

    2010-01-01

    State water quality monitoring has been augmented by volunteer monitoring programs throughout the United States. Although a significant effort has been put forth by volunteers, questions remain as to whether volunteer data are accurate and can be used by regulators. In this study, typical volunteer water quality measurements from laboratory and environmental samples in Iowa were analyzed for error and bias. Volunteer measurements of nitrate+nitrite were significantly lower (about 2-fold) than concentrations determined via standard methods in both laboratory-prepared and environmental samples. Total reactive phosphorus concentrations analyzed by volunteers were similar to measurements determined via standard methods in laboratory-prepared samples and environmental samples, but were statistically lower than the actual concentration in four of the five laboratory-prepared samples. Volunteer water quality measurements were successful in identifying and classifying most of the waters which violate United States Environmental Protection Agency recommended water quality criteria for total nitrogen (66%) and for total phosphorus (52%) with the accuracy improving when accounting for error and biases in the volunteer data. An understanding of the error and bias in volunteer water quality measurements can allow regulators to incorporate volunteer water quality data into total maximum daily load planning or state water quality reporting. ?? 2010 American Chemical Society.

  1. Exsanguination of lower limbs in healthy male subjects

    DEFF Research Database (Denmark)

    Blond, Lars; Kirketerp-Møller, Klaus; Sonne-Holm, Stig

    2002-01-01

    Gamma camera technique was used to assess the effectiveness of various exsanguination methods in 12 healthy male volunteers given an autologous injection of 99mTc-labeled erythrocytes. The methods used included elevation alone, Esmarch bandage, gauze bandage, and the Pomidor roll-cuff. The median...

  2. The effect of 8 days of strict bed rest on the incretin effect in healthy volunteers

    DEFF Research Database (Denmark)

    Nielsen, Signe Tellerup; Harder-Lauridsen, Nina Majlund; Benatti, Fabiana Braga

    2016-01-01

    Bed rest and physical inactivity are the consequences of hospital admission for many patients. Physical inactivity induces changes in glucose metabolism, but its effect on the incretin effect, which is reduced in, e.g., Type 2 diabetes, is unknown. To investigate how 8 days of strict bed rest...... affects the incretin effect, 10 healthy nonobese male volunteers underwent 8 days of strict bed rest. Before and after the intervention, all volunteers underwent an oral glucose tolerance test (OGTT) followed by an intravenous glucose infusion (IVGI) on the following day to mimic the blood glucose profile...... difference between the area under the curve for the insulin response during the OGTT and that of the corresponding IVGI, respectively. Concentrations of glucose, insulin, C-peptide, and GIP measured during the OGTT were higher after the bed rest intervention (all P

  3. Lower limb ischaemia and reperfusion injury in healthy volunteers measured by oxidative and inflammatory biomarkers

    DEFF Research Database (Denmark)

    Halladin, N. L.; Busch, Sarah Victoria Ekeløf; Alamili, M.;

    2015-01-01

    antagonist (IL-1Ra), IL-6, IL-10, TNF-receptor (TNF-R)I, TNF-RII and YKL-40. RESULTS: We found no significant increase in MDA in the muscle biopsies after reperfusion. Plasma levels of oxidative and pro- and anti-inflammatory parameters showed no significant differences between baseline and after reperfusion...... at any sampling time. CONCLUSION: Twenty minutes of lower limb ischaemia does not result in an ischaemia-reperfusion injury in healthy volunteers, measurable by oxidative and pro- and anti-inflammatory biomarkers in muscle biopsies and in the systemic circulation....... these interfering factors of surgery is, therefore, useful to test the potential of antioxidant and cytokine-modulatory treatments.The aim of this study was to characterize a human ischaemia-reperfusion model with respect to oxidative and inflammatory biomarkers. MATERIALS AND METHODS: Ten male volunteers were...

  4. Bioequivalence studies of two brands of meloxicam tablets in healthy Pakistani volunteers.

    Science.gov (United States)

    Hasan, Syed Muhammad Farid; Shoaib, Muhammad Harris; Hassan, Fouzia; Rehman, Inam-Ur

    2009-04-01

    The pharmacokinetic parameters of two oral formulations of meloxicam tablets were compared in a randomized, single oral dose; two treatments cross over design in 12 healthy male volunteers belonging to Pakistan under fasting conditions. After an overnight fast, the volunteers received 30 mg meloxicam and the blood samples were collected up to 96 hours and drug concentrations were determined by a validated HPLC method. Various pharmacokinetic parameters were determined from the plasma concentration-time curves of both formulations. The 90% confidence intervals obtained by analysis of variance were 87-94% for C(max) and 88-97% for AUC(0-t), that fell well within the acceptance range of 80-125%. Also, no significant difference (a=0.05, Wilcoxon Signed rank test) were detected between T(max) of both formulations. The two formulations were well tolerated and no adverse effect was reported during the study.

  5. 2008 LHC Open Days Training for volunteers

    CERN Multimedia

    2008-01-01

    Information and training sessions are being organised for Open Day volunteers. The Open Days Organising Committee is offering information and training sessions every Thursday in March from 2.00 p.m. to 3.30 p.m. in the Main Building Auditorium. The first session will be on Thursday 6 March. It is important that volunteers attend these sessions to familiarise themselves with the practical arrangements for the two Open Days and with the main messages to be conveyed to the general public in order to make the event a success. General information will be given out at each session, followed by information on a specific theme. The sessions will be organised as follows: 2.00 - 2.45 p.m. : first part - general information 2.45 - 3.30 p.m. : second part - specific information * 6 March - specific theme "How to answer questions about the fears surrounding the LHC" * A different theme will be addressed at each session. The themes of subsequent sessions (13 , 20, 27 March and 3 Ap...

  6. BOINC service for volunteer cloud computing

    CERN Document Server

    Høimyr, N; Buncic, P; Giovannozzi, M; Gonzalez, A; Harutyunyan, A; Jones, P L; Karneyeu, A; Marquina, M A; Mcintosh, E; Segal, B; Skands, P; Grey, F; Lombraña González, D; Zacharov, I; CERN. Geneva. IT Department

    2012-01-01

    Since a couple of years, a team at CERN and partners from the Citizen Cyberscience Centre (CCC) have been working on a project that enables general physics simulation programs to run in a virtual machine on volunteer PCs around the world. The project uses the Berkeley Open Infrastructure for Network Computing (BOINC) framework. Based on CERNVM and the job management framework Co-Pilot, this project was made available for public beta-testing in August 2011 with Monte Carlo simulations of LHC physics under the name "LHC@home 2.0" and the BOINC project: "Test4Theory". At the same time, CERN's efforts on Volunteer Computing for LHC machine studies have been intensified; this project has previously been known as LHC@home, and has been running the "Sixtrack" beam dynamics application for the LHC accelerator, using a classic BOINC framework without virtual machines. CERN-IT has set up a BOINC server cluster, and has provided and supported the BOINC infrastructure for both projects. CERN intends to evolve the setup i...

  7. Evolutionary stability in the asymmetric volunteer's dilemma.

    Directory of Open Access Journals (Sweden)

    Jun-Zhou He

    Full Text Available It is often assumed that in public goods games, contributors are either strong or weak players and each individual has an equal probability of exhibiting cooperation. It is difficult to explain why the public good is produced by strong individuals in some cooperation systems, and by weak individuals in others. Viewing the asymmetric volunteer's dilemma game as an evolutionary game, we find that whether the strong or the weak players produce the public good depends on the initial condition (i.e., phenotype or initial strategy of individuals. These different evolutionarily stable strategies (ESS associated with different initial conditions, can be interpreted as the production modes of public goods of different cooperation systems. A further analysis revealed that the strong player adopts a pure strategy but mixed strategies for the weak players to produce the public good, and that the probability of volunteering by weak players decreases with increasing group size or decreasing cost-benefit ratio. Our model shows that the defection probability of a "strong" player is greater than the "weak" players in the model of Diekmann (1993. This contradicts Selten's (1980 model that public goods can only be produced by a strong player, is not an evolutionarily stable strategy, and will therefore disappear over evolutionary time. Our public good model with ESS has thus extended previous interpretations that the public good can only be produced by strong players in an asymmetric game.

  8. Growing Your Career through Volunteering and Leadership

    Science.gov (United States)

    O'Riordan, C. A.; Meth, C.

    2007-12-01

    From giving your first paper at a scientific meeting to chairing committees that make multi-million dollar decisions, scientific organizations provide critical opportunities for growing your career. Many organizations support student activities by providing travel grants and fellowships - an important first step towards joining the larger scientific community. Beyond these standard opportunities, organizations also provide opportunities for students interested in gaining leadership experience, a skill not typically acquired in graduate science programs. For example, the Consortium for Leadership's Schlanger Ocean Drilling Fellowship provides research funds to graduate students, but also introduces the fellows to the communication skills needed to become successful members of their scientific community. Beyond student opportunities, volunteering provides mid-career and established scientists further experience in leadership. Opportunities exist in advising government science policy, guiding large-scale research programs, organizing large scientific meetings, and serving on non-profit boards. The variety of volunteer and leadership opportunities that are available give scientists at all stages of their career a chance to expand and diversify their experience, leading to new successes.

  9. Do monetary rewards crowd out intrinsic motivations of volunteers? Some empirical evidence for Italian volunteers

    OpenAIRE

    Damiano Fiorillo

    2009-01-01

    The paper studies the determinants of regular volunteering departing from previous literature on extrinsic and intrinsic motivations. It contributes to the literature investigating the role of monetary rewards to influence intrinsic motivation. Using a simple framework that allows me to study the effect of monetary rewards on intrinsic motivation, the paper shows, controlling for endogenous bias, that monetary rewards crowd-out intrinsic motivation.

  10. Studies on Anther Development of 4x Sexual Polyploidization Male Sterile Lines in Non-heading Chinese Cabbage%有性多倍化白菜四倍体雄性不育花药发育的解剖学研究

    Institute of Scientific and Technical Information of China (English)

    钟程; 田鑫; 张蜀宁; 张文华

    2012-01-01

    [目的]对有性多倍化雄性不育系花药的败育时期和方式进行研究,为雄性不育基础研究提供理论依据.[方法]以同源四倍体白菜为母本,以秋水仙素诱导筛选出含2n配子较高的二倍体为父本杂交获得四倍体不育系及其保持系为材料,采用常规石蜡切片法对其花药进行解剖学研究,观察其花药的败育时期.[结果]退化的雄蕊可分为4种类型,均败育于孢原细胞分化期,始终处在孢原细胞期,无绒毡层与花粉母细胞的分化,不形成药室,属孢子体败育型.[结论]有性多倍化白菜四倍体雄性不育的4种类型都是孢子体败育型.%[Objective]Cytological investigation on microsporogenesis of male sterility of sexual polyploidizationmale sterile lines in non-heading Chinese cabbage were studied to provide theoretical basis for the male sterility. [Method]Anther anatomical structure and development were observed using a light microscope through paraffin slices on the production of Ax CMS by sexual polyploidization and its maintainer line in Chinese cabbage. Abortion stage of 4x CMS was observed. [Jiesult] There were four types in the degraded stamens. The abortion of stamen occurred at the stage of archesporial cell differentiation,at which there was no differentiation of fibrous layer,tapetum and microspore mother cell. It belonged to non-sporange cytoplasmic male sterility. [Conclusion]Four types of the 4x sexual polyploidization CMS lines in non-heading Chinese cabbage were sporophyte abortion.

  11. A randomized controlled trial to promote volunteering in older adults.

    Science.gov (United States)

    Warner, Lisa M; Wolff, Julia K; Ziegelmann, Jochen P; Wurm, Susanne

    2014-12-01

    Volunteering is presumed to confer health benefits, but interventions to encourage older adults to volunteer are sparse. Therefore, a randomized controlled trial with 280 community-dwelling older German adults was conducted to test the effects of a theory-based social-cognitive intervention against a passive waiting-list control group and an active control intervention designed to motivate physical activity. Self-reports of weekly volunteering minutes were assessed at baseline (5 weeks before the intervention) as well as 2 and 6 weeks after the intervention. Participants in the treatment group increased their weekly volunteering minutes to a greater extent than participants in the control groups 6 weeks after the intervention. We conclude that a single, face-to-face group session can increase volunteering among older community-dwelling adults. However, the effects need some time to unfold because changes in volunteering were not apparent 2 weeks after the intervention.

  12. Does volunteering moderate the relation between functional limitations and mortality?

    Science.gov (United States)

    Okun, Morris A; August, Kristin J; Rook, Karen S; Newsom, Jason T

    2010-11-01

    Previous studies have demonstrated that functional limitations increase, and organizational volunteering decreases, the risk of mortality in later life. However, scant attention has been paid to investigating the joint effect of functional limitations and organizational volunteering on mortality. Accordingly, we tested the hypothesis that volunteering moderates the relation between functional limitations and risk of mortality. This prospective study used baseline survey data from a representative sample of 916 non-institutionalized adults 65 years old and older who lived in the continental United States. Data on mortality were extracted six years later from the National Death Index. Survival analyses revealed that functional limitations were associated with an increased risk of dying only among participants who never or almost never volunteered, suggesting that volunteering buffers the association between functional limitations and mortality. We conclude that although it may be more difficult for older adults with functional limitations to volunteer, they may receive important benefits from doing so.

  13. Thoracic costotransverse joint pain patterns: a study in normal volunteers

    Directory of Open Access Journals (Sweden)

    Wainner Robert S

    2008-10-01

    Full Text Available Abstract Background Pain referral patterns of asymptomatic costotransverse joints have not been established. The objective of this study was to determine the pain referral patterns of asymptomatic costotransverse joints via provocative intra-articular injection. Methods Eight asymptomatic male volunteers received a combined total of 21 intra-articular costotransverse joint injections. Fluoroscopic imaging was used to identify and isolate each costotransverse joint and guide placement of a 25 gauge, 2.5 inch spinal needle into the costotransverse joint. Following contrast medium injection, the quality, intensity, and distribution of the resultant pain produced were recorded. Results Of the 21 costotransverse joint injections, 16 (76% were classified as being intra-articular via arthrograms taken at the time of injection, and 14 of these injections produced a pain sensation distinctly different from that of needle placement. Average pain produced was 3.3/10 on a 0–10 verbal pain scale. Pain was described generally as a deep, dull ache, and pressure sensation. Pain patterns were located superficial to the injected joint, with only the right T2 injections showing referred pain 2 segments cranially and caudally. No chest wall, upper extremity or pseudovisceral pains were reported. Conclusion This study provides preliminary data of the pain referral patterns of costotransverse joints. Further research is needed to compare these findings with those elicited from symptomatic subjects.

  14. THE POTENTIAL OF EMPLOYEES ONLINE VOLUNTEERING IN ROMANIA

    OpenAIRE

    2013-01-01

    We have started our research based on the hypothesis that although the concept of online volunteering has a history of more than 30 years (Cravens, 2006) it seems not to be very well known and used in Romania. One the other site, Corporate Social Responsibility programs have gained popularity in our country in recent years and we were interested in analysing the connection existing between the three concepts of CSR – Corporate Volunteering – Online Volunteering along with their impact in the ...

  15. Offer of outgoing volunteer tourism in the Czech Republic

    OpenAIRE

    Bryndová, Karolína

    2015-01-01

    Bachelor thesis describes outgoing volunteer tourism in the Czech Republic through volunteer organizations that offer projects mainly for young people as a meaning leisure activity, but also organizations that are involved in rescue operations during various natural disasters and other emergencies. It then also describes types of projects as well as positive and negative impacts, benefits, and problems of international volunteering. Final survey identifies a profile of participants of these p...

  16. Networking for philanthropy: increasing volunteer behavior via social networking sites.

    Science.gov (United States)

    Kim, Yoojung; Lee, Wei-Na

    2014-03-01

    Social networking sites (SNSs) provide a unique social venue to engage the young generation in philanthropy through their networking capabilities. An integrated model that incorporates social capital into the Theory of Reasoned Action is developed to explain volunteer behavior through social networks. As expected, volunteer behavior was predicted by volunteer intention, which was influenced by attitudes and subjective norms. In addition, social capital, an outcome of the extensive use of SNSs, was as an important driver of users' attitude and subjective norms toward volunteering via SNSs.

  17. Leaving home: how older adults prepare for intensive volunteering.

    Science.gov (United States)

    Cheek, Cheryl; Piercy, Kathleen W; Grainger, Sarah

    2015-03-01

    Using the concepts in the Fogg Behavioral Model, 37 volunteers aged 50 and older described their preparation for intensive volunteering with faith-based organizations. Their multistage preparation process included decision points where respondents needed to choose whether to drop out or continue preparation. Ability was a stronger determinant of serving than motivation, particularly in terms of health and finances. This model can facilitate understanding of the barriers to volunteering and aid organizations in tailoring support at crucial points for potential older volunteers in intensive service.

  18. Towards a Production Volunteer Computing Infrastructure for HEP

    Science.gov (United States)

    Høimyr, N.; Marquina, M.; Asp, T.; Jones, P.; Gonzalez, A.; Field, L.

    2015-12-01

    Following the successful inclusion of virtualisation to volunteer computing for theory simulations back in 2011, the use of volunteer computing with BOINC and CernVM has been extended to cover simulations for the LHC experiments ATLAS, CMS and LHCb. This paper describes the status of the BOINC volunteer computing platform at CERN used for LHC@home and how it has been designed to address a heterogeneous environment of different user communities with different computing infrastructure. The aim of the recent developments is to provide a volunteer computing platform that the experiments can build upon to exploit opportunistic resources. Furthermore, new developments of common solutions to span user authentication domains are explained.

  19. Occlusal status in Asian male adults : Prevalence and ethnic variation

    NARCIS (Netherlands)

    Soh, J; Sandham, John; Chin, Yeen

    2005-01-01

    The purpose of this study was to determine the occlusal status in young Asian male adults of three ethnic groups. Study models of a sample of male army recruits (N = 339, age 1722 years) with no history of orthodontic treatment were assessed. The ethnic proportions of the sample were Chinese 76.1% (

  20. A Systems Perspective on Volunteered Geographic Information

    Directory of Open Access Journals (Sweden)

    Victoria Fast

    2014-12-01

    Full Text Available Volunteered geographic information (VGI is geographic information collected by way of crowdsourcing. However, the distinction between VGI as an information product and the processes that create VGI is blurred. Clearly, the environment that influences the creation of VGI is different than the information product itself, yet most literature treats them as one and the same. Thus, this research is motivated by the need to formalize and standardize the systems that support the creation of VGI. To this end, we propose a conceptual framework for VGI systems, the main components of which—project, participants, and technical infrastructure—form an environment conducive to the creation of VGI. Drawing on examples from OpenStreetMap, Ushahidi, and RinkWatch, we illustrate the pragmatic relevance of these components. Applying a system perspective to VGI allows us to better understand the components and functionality needed to effectively create VGI.

  1. AVOCLOUDY: a simulator of volunteer clouds

    DEFF Research Database (Denmark)

    Sebastio, Stefano; Amoretti, Michele; Lluch Lafuente, Alberto

    2015-01-01

    providers. The relationship between users and providers is defined by a service-level agreement, where the non-fulfillment of its terms is regulated by the associated penalty fees. Therefore, it is important that the providers adopt proper monitoring and managing strategies. Despite their reduced......, with the purpose to ‘green’ them. Indeed, the combination of data center and volunteer resources, managed by agents, allows one to obtain a more robust and scalable cloud computing platform. The increased challenges in designing such a complex system can benefit from a simulation-based approach, to test autonomic...... management solutions before their deployment in the production environment. However, currently available simulators of cloud platforms are not suitable to model and analyze such heterogeneous, large-scale, and highly dynamic systems. We propose the AVOCLOUDY simulator to fill this gap. This paper presents...

  2. When Volunteering Breeds Trust – and When it Does Not A Panel Study of the Volunteering – Trust Relationship

    OpenAIRE

    Bekkers, René

    2006-01-01

    It is a common belief that participation in voluntary associations makes citizens more trusting of others. This paper reports longitudinal analyses of volunteering and trust on the Giving in the Netherlands Panel Study (2002-2004; n=1246) refuting this belief. I find that volunteering has little positive impact on trust because social experiences of volunteers in organizations are not always positive. A second reason is that values are relatively stable over the life course. Finally, there ar...

  3. Body Image Concerns in College-Aged Male Physical Education Students: A Descriptive Inquiry

    Science.gov (United States)

    Olson, Michele S.; Esco, Michael R.; Willifo, Hank

    2009-01-01

    The purpose of this study was to examine body image concerns in college-aged male physical education majors. Sixty volunteers completed validated body image instruments including two-dimensional figure drawings. In general, the sample reported that they preferred a larger, more muscular physique reflective of male images that currently abound the…

  4. Investing in volunteering: measuring social returns of volunteer recruitment, training, and management

    OpenAIRE

    G. Manetti; M. Bellucci; E.Como; L. Bagnoli

    2014-01-01

    In this paper we analyze the costs and benefits of the investments that non-profit organizations (NPOs) make for the recruitment, training, and management of volunteers. Our main research question is whether we can apply the Social Return on Investment (SROI) to the identification and quantification of social returns in monetary terms. We believe that the “SROI of volunteering” may represent an effective instrument of internal control for NPOs for improving efficiency and sustainability. In o...

  5. Mé Féin nó an Pobal: Social Processes and Connectivity in Irish Volunteering

    Directory of Open Access Journals (Sweden)

    Marie Claire Van Hout

    2011-01-01

    Full Text Available Ireland has a longstanding history of diverse volunteer action (Volunteering Ireland, 2010a. Ireland’s current economic recession has impacted on the community and voluntary sector, with frequent contraction in staff numbers and incomes, and increasing reliance on volunteer participation (Harvey, 2012. This study utilised social capital theory to garner a phenomenological understanding of the contribution of volunteering to perceived social capital amongst Irish volunteers and host organisation representatives. A convenience sample of 28 participants (17 volunteers and 11 organisation representatives was interviewed. A shift in personal and social definitions of volunteering were described, with informal volunteering increasingly replaced by structured, formalized and regulated volunteer placements. Volunteers described their experiences as contributing to increased personal well being and sense of purpose, development of friendships and meeting new people. The volunteer participants identified volunteering activity as a specified community need, providing work related experiences, fulfillment in free time and opportunity for up-skilling. Integration of volunteers into the organisation’s workforce was described as dependent on duration, intensity of interaction and scope of volunteer contributions. Power differentials and a lack of trust between volunteers and staff, was described, as was a lack of volunteer recognition staff. Subsequently, some volunteers identified and aligned themselves within the wider social volunteer network rather than their host organisation. The research reflected an emergent consumerist approach to volunteering and underscores the need to preserve informal social networks of community volunteers, alongside the development of more formalized work specific routes for volunteering in Ireland.

  6. Three Steps to Engage Volunteers in Membership Marketing

    Science.gov (United States)

    Rossell, Tony

    2011-01-01

    There is a big world out there, and volunteers can make a significant impact in helping one reach out to others and grow his/her PTA membership. In fact, word-of-mouth marketing tied for the top spot as the most effective method of new member recruitment in Marketing General's 2010 Membership Marketing Benchmarking Report. So getting volunteers'…

  7. National context, religiosity and volunteering: Results from 53 countries

    NARCIS (Netherlands)

    Ruiter, S.; Graaf, N.D. de

    2006-01-01

    To what extent does the national religious context affect volunteering? Does a religious environment affect the relation between religiosity and volunteering? To answer these questions, this study specifies individual level, contextual level, and cross-level interaction hypotheses. The authors test

  8. The Impact of Institutional Mission on Student Volunteering

    Science.gov (United States)

    Sullivan, Susan Crawford; Ludden, Alison Bryant; Singleton, Royce A., Jr.

    2013-01-01

    This study examined patterns and predictors of volunteering among students at a liberal arts college with an institutional culture that strongly promotes community service. Results showed that predictors varied across four different types of volunteering: community service, social action, religious service, and service to the college. Year in…

  9. National Context, Religiosity, and Volunteering : Results from 53 Countries

    NARCIS (Netherlands)

    Ruiter, Stijn; Graaf, Nan Dirk de

    2008-01-01

    To what extent does the national religious context affect volunteering? Does a religious environment affect the relation between religiosity and volunteering? To answer these questions, this study specifies individual level, contextual level, and cross-level interaction hypotheses. The authors test

  10. The Association of Childhood Personality Type with Volunteering during Adolescence

    Science.gov (United States)

    Atkins, Robert; Hart, Daniel; Donnelly, Thomas M.

    2005-01-01

    Using a longitudinal design, we investigated the relation of childhood personality type to volunteering during adolescence. We hypothesized that participants with more adaptive personality functioning during childhood would be more likely to volunteer during adolescence and that membership in social organizations would mediate the relation of…

  11. 75 FR 56501 - Information Collection; Land Management Agency Volunteer Surveys

    Science.gov (United States)

    2010-09-16

    ... exists regarding volunteering in general, there is very little rigorous, academic research on volunteering as it applies to LMAs, largely because there is no reliable, uniform, and comprehensive data... management values and objectives; and will facilitate further application of findings. The exact number...

  12. School Volunteer Program. A Two-Year Evaluation Report.

    Science.gov (United States)

    Bartholomew Consolidated School Corp., Columbus, IN.

    This report evaluates a volunteer program established in the Bartholomew Consolidated School Corporation in Columbus, Indiana. Areas identified for evaluation were (1) the fulfillment or achievement of program objectives; (2) measurable differences in volunteers' attitudes toward the schooling process and parenting skills, as well as their…

  13. 28 CFR 548.14 - Community involvement (volunteers, contractors).

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Community involvement (volunteers... Community involvement (volunteers, contractors). (a) The institution's chaplain may contract with representatives of faith groups in the community to provide specific religious services which the chaplain...

  14. Volunteers as Products of a Zoo Conservation Education Program

    Science.gov (United States)

    Bixler, Robert D.; Joseph, Stephanie L.; Searles, Vicki M.

    2014-01-01

    Zoos embrace docents/volunteers as a means of interpreting the threats to wildlife and biodiversity to visitors. To accomplish this, zoos provide docents' education, training, and work experience. Docents themselves also engage in solitary and social wildlife experiences outside of their volunteer obligations. This study examined what…

  15. Who Benefits from Volunteering? Variations in Perceived Benefits

    Science.gov (United States)

    Morrow-Howell, Nancy; Hong, Song-Iee; Tang, Fengyan

    2009-01-01

    Purpose: The purpose of this study was to document the benefits of volunteering perceived by older adults and to explain variation in these self-perceived benefits. Design and Methods: This is a quantitative study of 13 volunteer programs and 401 older adults serving in those programs. Program directors completed telephone interviews, and older…

  16. Volunteers as Products of a Zoo Conservation Education Program

    Science.gov (United States)

    Bixler, Robert D.; Joseph, Stephanie L.; Searles, Vicki M.

    2014-01-01

    Zoos embrace docents/volunteers as a means of interpreting the threats to wildlife and biodiversity to visitors. To accomplish this, zoos provide docents' education, training, and work experience. Docents themselves also engage in solitary and social wildlife experiences outside of their volunteer obligations. This study examined what motivates…

  17. Leveraging Telehealth to Bring Volunteer Physicians Into Underserved Communities.

    Science.gov (United States)

    Uscher-Pines, Lori; Rudin, Robert; Mehrotra, Ateev

    2016-11-28

    Many disadvantaged communities lack sufficient numbers of local primary care and specialty physicians. Yet tens of thousands of physicians, in particular those who are retired or semiretired, desire meaningful volunteer opportunities. Multiple programs have begun to use telehealth to bridge the gap between volunteer physicians and underserved patients. In this brief, we describe programs that are using this model and discuss the promise and pitfalls. Physician volunteers in these programs report that the work can be fulfilling and exciting, a cutting-edge yet convenient way to remain engaged and contribute. Given the projected shortfall of physicians in the United States, recruiting retired and semiretired physicians to provide care through telehealth increases the total supply of active physicians and the capacity of the existing workforce. However, programs typically use volunteers in a limited capacity because of uncertainty about the level and duration of commitment. Acknowledging this reality, most programs only use volunteer physicians for curbside consults rather than fully integrating them into longitudinal patient care. The part-time availability of volunteers may also be difficult to incorporate into the workflow of busy safety net clinics. As more physicians volunteer in a growing number of telehealth programs, the dual benefits of enriching the professional lives of volunteers and improving care for underserved communities will make further development of these programs worthwhile.

  18. 美国文学中华人男性刻板形象的后殖民解构%The Deconstruction of Chinese Male Stereotypic Image in American Literature

    Institute of Scientific and Technical Information of China (English)

    程昊

    2014-01-01

    两百年来,美国华人男性为美国的发展做出了巨大的贡献,然而在美国主流文化中,他们被描述成卑劣低下、愚昧无知、狡猾邪恶,难以同化的异教徒,甚至被“女性化”阉割的“他者”刻板形象。%In the past two hundred years,Chinese men have made a great contribution to the development of the USA.Whereas,their contribution is seldom mentioned in American mainstream society and they are depicted as the stereotypic image which is inferior,illit-erate,vicious,unassimilated and “castrated”.This thesis focuses on the deconstruction of the reasons which form this stereotypic im-age.

  19. The pharmacokinetic characters of simvastatin after co-administration with Shexiang Baoxin Pill in healthy volunteers' plasma.

    Science.gov (United States)

    Tao, Jianfei; Jiang, Peng; Peng, Chengcheng; Li, Min; Liu, Runhui; Zhang, Weidong

    2016-07-15

    To investigate the effect of Shexiang Baoxin Pill (SBP), a tranditional Chinese medicine, on the pharmacokinetic (PK) parameters of simvastatin in healthy volunteers' plasma, a quantitative method was developed using an Agilent G6410A rapid performance liquid chromatography (RPLC) coupled with triple quadrupole mass spectrometry system. The established method was rapid with high extraction recovery and successfully applied for the determination of simvastatin in plasma of 16 healthy volunteers. The results demonstrated that the MRT(0-∞), T1/2 and Tmax value of simvastatin were significantly decreased, while the AUC(0-t) and Cmax values of smivastatin were increased by SBP. The pharmacokinetic study demonstrated that the metabolism parameters of simvastatin could be affected by SBP and the potential drug-drug interaction should be noted in the future clinical practice.

  20. Reference values for cardiopulmonary exercise testing in healthy volunteers: the SHIP study.

    Science.gov (United States)

    Koch, B; Schäper, C; Ittermann, T; Spielhagen, T; Dörr, M; Völzke, H; Opitz, C F; Ewert, R; Gläser, S

    2009-02-01

    Cardiopulmonary exercise testing (CPET) is a widely applied clinical procedure. The aim of the present study was to acquire a comprehensive set of reference values for cardiopulmonary responses to exercise and to evaluate possible associations with sex, age and body mass index (BMI). A standardised progressive incremental exercise protocol on a cycle ergometer was applied to 1,708 volunteers of a cross-sectional epidemiologic survey, called "Study of Health in Pomerania". Individuals with cardiopulmonary disorders, or echocardiographic or lung function pathologies, were excluded. The influence of potential confounding factors, such as smoking, taking beta-blockers, hypertension, diastolic dysfunction, BMI and physical activity, were analysed for their influencing power. Reference values of CPET parameters were determined by regression analyses. Of the volunteers, 542 current smokers and obese individuals were excluded for not being representative of a healthy population. The final sample size was 534 (253 males), with age 25-80 yrs. The current study provides a representative set of reference values for CPET parameters based on age and weight. Sex and age have a significant influence on exercise parameters. While addressing the problem of a selection bias, the current study provides the first comprehensive set of reference values obtained in a large number of healthy volunteers within a population-based survey.

  1. Normative values of pulmonary function testing in Chinese adults

    Institute of Scientific and Technical Information of China (English)

    郑劲平; 钟南山

    2002-01-01

    Objectives To compare the difference in pulmonary function between Caucasians and Chinese and assess the best reference values of pulmonary function for Chinese adults. Methods Values for pulmonary function were predicted by tests on 4773 Chinese healthy subjects (male: 2560, female: 2213, aged 15-78 years) in six parts (north, northeast, northwest, east, southwest and south) of China. Prediction equations of the European Community for Steel and Coal (ECSC), other equations for overseas Chinese or for Caucasians were also selected. The regression coefficients of forced vital capacity (FVC), forced expiratory volume in one second (FEV1), FEV1/FVC, total lung capacity (TLC) and residual volume (RV) were summarized. Results ECSC predictions were closer to the Chinese ones than other selected equations. Comparison with ECSC predictions showed that on average the values for FVC, FEV1 were 5.3% smaller in Chinese males and 3.3% smaller in Chinese females, with the maximal differences in south China and the minimal differences in North China. RV and TLC in Chinese were lower than in Caucasians (males 4.8%, 5.5%, respectively; females 8.7% and 6.0%, respectively). Conversion factors were given for adjusting ECSC equations to fit Chinese. Conclusions For predicting values of pulmonary function in Chinese, we suggest to use the equations reported here. Alternatively, ECSC regression equations may be used with appropriate conversion factors.

  2. Municipality and Neighborhood Influences on Volunteering in Later Life.

    Science.gov (United States)

    Dury, Sarah; Willems, Jurgen; De Witte, Nico; De Donder, Liesbeth; Buffel, Tine; Verté, Dominique

    2016-06-01

    This article explores the relationships between municipality features and volunteering by older adults. In the literature, strong evidence exists of the influence of place on older people's health. However, the question how neighborhoods and municipalities promote or hinder volunteer participation remains under-explored. Data for the research are derived from the Belgian Aging Studies. We estimate logistic multilevel models for older individuals' engagement in volunteering across 141 municipalities in Belgium (N = 67,144). Analysis shows that neighborhood connectedness, neighborhood satisfaction, home ownership, and presence of services predict voluntary engagement at older ages. The findings support that perceptions and quality of social resources that relate to neighborhoods may be important factors to explain volunteering among older adults. Moreover, the findings suggest that volunteering in later life must be considered within a broader framework.

  3. "Communication is everything:" The experiences of volunteers who use AAC.

    Science.gov (United States)

    Trembath, David; Balandin, Susan; Stancliffe, Roger J; Togher, Leanne

    2010-06-01

    The aim of this study was to explore the impact that using augmentative and alternative communication (AAC) had on the experiences of 24 adults with lifelong disabilities who worked as volunteers. This research forms part of a larger qualitative study of volunteering amongst adults who use AAC. Based on in-depth interviews and grounded theory analysis, the results indicate that communication is central to successful volunteering and, in particular, that access to AAC has the potential to provide valuable support to individuals with complex communication needs who want to volunteer. However, a number of barriers must be addressed in order for this potential to be achieved. Strategies for promoting and supporting adults who use AAC and want to volunteer are discussed.

  4. Gender and religious differences associated with volunteering in later life.

    Science.gov (United States)

    Manning, Lydia K

    2010-01-01

    The purpose of this study is to use a nationally representative sample of older adults in the United States to investigate the effect gender and religiosity has on volunteer behavior in later life. This study looks specifically at the gender and religious differences associated with volunteering in later life. Accounting for gender and religious differences, more specifically, this study examines the assumption that older women are more likely to volunteer in later life as opposed to men, and that gender is a better predictor than being religious for the likelihood of occupying a volunteer role in later life. This study poses questions about the differences in gender and religiosity associated with volunteering in later life; the results indicate there is more work to be done as we conduct research that is clearer about how volunteerism and religiosity are measured in relation to gender, and the overall impact these differences have for older women and their respective communities.

  5. Predicting professional quality of life among professional and volunteer caregivers.

    Science.gov (United States)

    Avieli, Hila; Ben-David, Sarah; Levy, Inna

    2016-01-01

    This study is one of the few that has compared volunteers' professional quality of life (PQL), which includes secondary traumatic stress (STS), burnout, and compassion satisfaction (CS), to those of professional caregivers. In addition, the research compared the ethical behavior of volunteers with that of professional therapists and examined the connection between years of experience, ethical behavior, and PQL. One hundred eighty-three volunteers and professional caregivers filled out a sociodemographic questionnaire, an Ethical Behavior Questionnaire and the Professional Quality of Life (ProQOL) questionnaire. The results indicated that professional caregivers report lower levels of STS and burnout, and higher levels of CS and ethical behavior compared with volunteer caregivers. Moreover, the findings suggest that ethical behavior correlates with STS, burnout, and CS. Ethical behavior has a protective value for mental health caregivers. The discussion emphasizes the value of a professional code of ethics and ethical training for professional and volunteering caregivers.

  6. English Training for College Student Volunteers at Sports Events

    Institute of Scientific and Technical Information of China (English)

    LIU Wei

    2014-01-01

    This paper studies English training for student volunteers at large scale sports events with a comprehensive investigation of the undergraduate student volunteers from Capital University of Physical Education who have taken part in large scale sports events. By examining the current volunteer training situation, the author finds that there is a sever lack of professional and system-atical English training for student volunteers at large scale sports events. The study shows focusing on sports events knowledge and requirements of the volunteers’specific job is crucial to the service level of the volunteers. The study concludes that the problem can be solved by developing new course books, innovating new flexible training methods, and offering more comprehensive training content. The recommended training methods include intensive group training, computer aided teaching, task training and on-the-spot training to make them fit their work soon.

  7. Volunteers and Ex-Volunteers: Paths to Civic Engagement Through Volunteerism Voluntarios y Ex Voluntarios: Perfiles de Participación Ciudadana a Través del Voluntariado

    Directory of Open Access Journals (Sweden)

    Elena Marta

    2010-11-01

    Full Text Available The study described is part of a broader longitudinal and multi-methodological research project aimed at investigating volunteerism in young people, in order to understand the reasons for the initial choice to volunteer but, more specifically, the reasons to sustain or quit voluntary involvement, as well as the effects of volunteerism. Eighteen volunteers and 18 ex-volunteers, 50% male and 50% female, aged between 22 and 29 years old, from 2 regions in northern Italy (Lombardy and Emilia Romagna participated in in-depth interviews. The paper-and-pencil analysis of the interview pointed to the emergence of several core categories: motivations to volunteer, relations within the organization, influence of family, and effects of volunteerism, especially as related to the process of identity and citizenship construction. On the basis of these categories, 4 typologies were identified: 2 with respect to volunteers (producers of active citizenship and volunteers for personal necessity and 2 related specifically to ex-volunteers (ex-volunteers witnesses for solidarity and active citizenship and ex-volunteers by chance.El estudio descrito es parte de un proyecto de investigación longitudinal y multi-metodológico más amplio sobre el voluntariado juvenil, realizado con el propósito de entender las razones que tuvieron los jóvenes para elegir el voluntariado y, específicamente, las razones para mantener o abandonar el compromiso, así como los efectos de dicho voluntariado. Participaron en entrevistas en profundidad 18 voluntarios y 18 ex-voluntarios, 50% hombres y 50% mujeres, entre 22 y 29 años de edad, de 2 regiones del norte de Italia (Lombardía y Emilia Romagna. El análisis de la entrevista de lápiz y papel permitió trazar varias categorías centrales: las motivaciones al voluntariado, las relaciones dentro de la organización, la influencia de la familia y los efectos del propio voluntariado, especialmente en relación con el proceso de

  8. Pharmacokinetics of GW433908, a prodrug of amprenavir, in healthy male volunteers.

    Science.gov (United States)

    Falcoz, Christine; Jenkins, Julian M; Bye, Carole; Hardman, Timothy C; Kenney, Kathy B; Studenberg, Scott; Fuder, H; Prince, William T

    2002-08-01

    These two Phase I, open-label, single-dose, randomized, crossoverstudies in 40 healthymale subjects investigated the pharmacokinetic and safety profiles of various formulations of the amprenavir prodrug GW433908 in the presence and absence of food compared with amprenavir capsules. GW433908 is a phosphate ester prodrug of the antiretroviral protease inhibitor amprenavir, with improved solubility over the parent molecule and a potential for reduced pill burden on current dosing regimens. The calcium salt of the prodrug, GW433908G, was selected for further investigation, as it appeared to offer the greatest potential for the development of new drug formulations. In the fasting state, (1) GW433908G tablet and suspension were bioequivalent in terms of both AUC and Cmax, and (2) GW433908G tablet and suspension were bioequivalent to amprenavir capsules for AUC; however, Cmax was lower with GW433908G. After a high-fat meal compared with fasting, (1) the bioavailability of GW433908G suspension was decreased by 20% and Cmax by 41%, and (2) for GW433908G tablets, there was no influence on AUC(12% lower Cmax). After a low-fat meal compared with fasting, (1) there was bioequivalence for GW433908G tablets, but (2) bioavailability was decreased by 23% for amprenavir capsules (Cmax was also lower, by 46%). Overall, for GW433908G and amprenavir capsules, food had a negligible influence on plasma concentration at 12 hours postdose (C12). Whether administered as tablets or suspension, GW433908G pharmacokinetics was only slightly affected by food. GW433908G tablets were well tolerated and delivered plasma amprenavir concentrations equivalent to the recommended therapeutic amprenavir dose but with fewer tablets. The possibility of a lower pill burden offered by GW433908 may be of clinical benefit in the treatment of HIV infection.

  9. Central nervous system effects of haloperidol on THC in healthy male volunteers

    NARCIS (Netherlands)

    Liem-Moolenaar, Marieke; te Beek, Erik T; de Kam, Marieke L; Franson, Kari L; Kahn, René S; Hijman, Ron; Touw, Daan; van Gerven, Joop M A

    2010-01-01

    In this study, the hypothesis that haloperidol would lead to an amelioration of Δ9-tetrahydrocannabinol (THC)-induced 'psychotomimetic' effects was investigated. In a double-blind, placebo-controlled, partial three-way crossover ascending dose study the effects of THC, haloperidol and their combinat

  10. Single-dose oral pharmacokinetics of three formulations of thalidomide in healthy male volunteers.

    Science.gov (United States)

    Teo, S K; Colburn, W A; Thomas, S D

    1999-11-01

    Thalidomide was recently approved in the United States for the treatment of erythema nodosum leprosum, a complication of leprosy. The present study determined the bioequivalence and pharmacokinetics of Celgene's commercial and clinical trial thalidomide formulations and the Brazilian Tortuga formulation in an open-label, single-dose, three-way crossover design. Seventeen healthy subjects were given 200 mg of thalidomide on three occasions, and blood samples were collected over 48 hours. Pharmacokinetic parameters were determined using compartmental methods for the two Celgene formulations and using noncompartmental methods for all three formulations. All subjects reported adverse events, none of which was serious or unexpected. Celgene formulations were bioequivalent when comparing Cmax, tmax, and AUC. There was significant variability in plasma levels from the Tortuga formulation, giving a mean profile that was distinctly different from the two Celgene formulations with a lower Cmax value and a longer terminal phase. The lower Cmax was probably due to slower absorption. The terminal rate constant for the Tortuga formulation was significantly less, giving rise to a terminal half-life of 15 hours compared to about 5 to 6 hours for the Celgene formulations. Confidence intervals for Cmax between the Tortuga and the Celgene formulations were outside the 80% to 125% range, indicating a lack of bioequivalence. Extent of absorption, as measured by AUC0-infinity, was approximately equal for all three formulations. Terminal half-life for Tortuga was two to three times longer compared to the Celgene formulations and is clear evidence for absorption rate limitations. The two Celgene formulations showed similar pharmacokinetic parameters with profiles that were best described by a one-compartment model with first-order absorption and elimination. The authors conclude that Celgene's clinical trial and commercial thalidomide formulations are similar to each other and distinctly different from the Tortuga formulation and that all three formulations exhibited absorption rate-limited elimination.

  11. The Challenge of Volunteering Frequency in Croatia--Can Volunteers Contribute to the Social Capital Development Once a Year?

    Science.gov (United States)

    Culum, Bojana; Forcic, Gordana

    2008-01-01

    Volunteering is one of the strongest elements of shaping democratic change within the society. It is also an essential element in citizenship development and in re-establishing a sense of community. Volunteering empowers individuals, builds solidarity, encourages participation and protects vulnerable groups against social and economic…

  12. When Volunteering Breeds Trust – and When it Does Not A Panel Study of the Volunteering – Trust Relationship

    NARCIS (Netherlands)

    Bekkers, René

    2006-01-01

    It is a common belief that participation in voluntary associations makes citizens more trusting of others. This paper reports longitudinal analyses of volunteering and trust on the Giving in the Netherlands Panel Study (2002-2004; n=1246) refuting this belief. I find that volunteering has little pos

  13. Socialising adolescent volunteering : How important are parents and friends? Age dependent effects of parents and friends on adolescents' volunteering behaviours

    NARCIS (Netherlands)

    Van Goethem, Anne A J; van Hoof, Anne; van Aken, Marcel A G; Orobio de Castro, Bram; Raaijmakers, Quinten A W

    2014-01-01

    This study examined the relative importance of best friend's and parents' volunteering and civic family orientation (combined with open family communication) in adolescent volunteering, and the moderating effect of age. Results, involving 698 adolescents (M age. = 15.19; SD= 1.43), revealed that ado

  14. Socialising adolescent volunteering: how important are parents and friends? Age dependent effects of parents and friends on adolescents' volunteering behaviours

    NARCIS (Netherlands)

    van Goethem, A.A.J.; van Hoof, A.; van Aken, M.A.G.; Orobio de Castro, B.; Raaijmakers, Q.A.W.

    2014-01-01

    This study examined the relative importance of best friend's and parents' volunteering and civic family orientation (combined with open family communication) in adolescent volunteering, and the moderating effect of age. Results, involving 698 adolescents (M age = 15.19; SD = 1.43), revealed that ado

  15. Measuring the Impacts of a Volunteer-Based Community Development Program in Developing Volunteers' Leadership Skills

    Science.gov (United States)

    Meier, Amy; Singletary, Loretta; Hill, George

    2012-01-01

    This article summarizes the results of an evaluation of the impacts of a community development program to develop leadership skills in its adult volunteers. The evaluation featured 20 questions about leadership skills learned as a result of volunteer experiences. Data analysis strategies beyond a simple means ranking resulted in evidence…

  16. Study on Differences in Spermatogenic Suppression between Azoospermic and Oligozoospermic Responders Treated with Levonorgestrel Implant Plus Testosterone Undecanoate Injectable in Chinese Men

    Institute of Scientific and Technical Information of China (English)

    Si-tian LIU; You-lun GUI; W.J. Bremner; Er-sheng GAO; Chang-hai HE

    2003-01-01

    Objective To investigate possible causes resulting in the differences in the spermatogenesis suppression on individual treated with levonorgestrel (LNG) implants and testosterone undecanoate(TU) injectable Methods Totally 21 Chinese male volunteers were given treatment with LNG implants (four rods, 75 mg/rod) and intramuscular injection of TU (500 mg, bimonthly for 3 times). According to the effects of treatment, they were divided into two groups, namely, azoospermia group (group A) and oligozoospermia group (group 0). Then seminal FSH, LH, T and estradiol (E2)were determined by immunoenzymetric assay, while seminal and serum dihydrotachysterol (DHT)and serum sex hormone binding globulin (SHBG) were by radioimmunoassay, and seminal transferrin (Tf) by scatter turbidimetry assay.Results Seminal FSH, LH and serum DHT, SHBG, FTI (T/SHBG × 100) levels were significantly lower in group A than in group O, while higher seminal concentrations of E2 were observed in azoospermia group.Conclusion The differences in the spermatogenic suppression in Chinese men might be attributed to different rate of peripheral androgen metabolism, variations in serum SHBG levels,5a-reductase activity and individual aromatase activity during LNG plus TU administration. In addition, seminal sex hormones might be more sensitive indexes to assess the extent of feedback inhibition on hypothalamus-pituitary-testis with exogenous testosterone plus progestogen in the efficacy hormone male contraceptive trials.

  17. Using volunteered geographic information to visualize ...

    Science.gov (United States)

    Volunteered geographic information (VGI), specifically geotagged photographs available from social media platforms, is a promising technology that can be utilized to identify public values for ecosystem goods and services in a defined geographic area. VGI can help researchers indirectly survey and report on the values and preferences of communities involved in restoration and revitalization projects. We are using geotagged images from three social media platforms: Flickr, Instagram, and Panaramio. Images are obtained for the neighborhoods to the St. Louis River in the Duluth, MN and analyzed along several dimensions including the spatial distribution of images from each platform and the types and frequencies of social values and ecosystem service depicted. This study will demonstrate a method for translating the values of ecosystem goods and services as captured in social media into spatially-explicit data. Study outcomes are the incorporation of social media-derived indicators of ecosystems services into City of Duluth’s Comprehensive Planning and community revitalization efforts, habitat restoration in a Great Lakes Area of Concern, and the USEPA’s Office of Research and Development Sustainable and Healthy Community research. Not applicable

  18. A Method for Analyzing Volunteered Geographic Information ...

    Science.gov (United States)

    Volunteered geographic information (VGI) can be used to identify public valuation of ecosystem services in a defined geographic area using photos as a representation of lived experiences. This method can help researchers better survey and report on the values and preferences of stakeholders involved in rehabilitation and revitalization projects. Current research utilizes VGI in the form of geotagged social media photos from three platforms: Flickr, Instagram, and Panaramio. Social media photos have been obtained for the neighborhoods next to the St. Louis River in Duluth, Minnesota, and are being analyzed along several dimensions. These dimensions include the spatial distribution of each platform, the characteristics of the physical environment portrayed in the photos, and finally, the ecosystem service depicted. In this poster, we focus on the photos from the Irving and Fairmount neighborhoods of Duluth, MN to demonstrate the method at the neighborhood scale. This study demonstrates a method for translating the values expressed in social media photos into ecosystem services and spatially-explicit data to be used in multiple settings, including the City of Duluth’s Comprehensive Planning and community revitalization efforts, habitat restoration in a Great Lakes Area of Concern, and the USEPA’s Office of Research and Development. This poster will demonstrate a method for translating values expressed in social media photos into ecosystem services and spatially

  19. Prediction of psilocybin response in healthy volunteers.

    Directory of Open Access Journals (Sweden)

    Erich Studerus

    Full Text Available Responses to hallucinogenic drugs, such as psilocybin, are believed to be critically dependent on the user's personality, current mood state, drug pre-experiences, expectancies, and social and environmental variables. However, little is known about the order of importance of these variables and their effect sizes in comparison to drug dose. Hence, this study investigated the effects of 24 predictor variables, including age, sex, education, personality traits, drug pre-experience, mental state before drug intake, experimental setting, and drug dose on the acute response to psilocybin. The analysis was based on the pooled data of 23 controlled experimental studies involving 409 psilocybin administrations to 261 healthy volunteers. Multiple linear mixed effects models were fitted for each of 15 response variables. Although drug dose was clearly the most important predictor for all measured response variables, several non-pharmacological variables significantly contributed to the effects of psilocybin. Specifically, having a high score in the personality trait of Absorption, being in an emotionally excitable and active state immediately before drug intake, and having experienced few psychological problems in past weeks were most strongly associated with pleasant and mystical-type experiences, whereas high Emotional Excitability, low age, and an experimental setting involving positron emission tomography most strongly predicted unpleasant and/or anxious reactions to psilocybin. The results confirm that non-pharmacological variables play an important role in the effects of psilocybin.

  20. Prediction of psilocybin response in healthy volunteers.

    Science.gov (United States)

    Studerus, Erich; Gamma, Alex; Kometer, Michael; Vollenweider, Franz X

    2012-01-01

    Responses to hallucinogenic drugs, such as psilocybin, are believed to be critically dependent on the user's personality, current mood state, drug pre-experiences, expectancies, and social and environmental variables. However, little is known about the order of importance of these variables and their effect sizes in comparison to drug dose. Hence, this study investigated the effects of 24 predictor variables, including age, sex, education, personality traits, drug pre-experience, mental state before drug intake, experimental setting, and drug dose on the acute response to psilocybin. The analysis was based on the pooled data of 23 controlled experimental studies involving 409 psilocybin administrations to 261 healthy volunteers. Multiple linear mixed effects models were fitted for each of 15 response variables. Although drug dose was clearly the most important predictor for all measured response variables, several non-pharmacological variables significantly contributed to the effects of psilocybin. Specifically, having a high score in the personality trait of Absorption, being in an emotionally excitable and active state immediately before drug intake, and having experienced few psychological problems in past weeks were most strongly associated with pleasant and mystical-type experiences, whereas high Emotional Excitability, low age, and an experimental setting involving positron emission tomography most strongly predicted unpleasant and/or anxious reactions to psilocybin. The results confirm that non-pharmacological variables play an important role in the effects of psilocybin.

  1. The impact of volunteer mentoring schemes on carers of people with dementia and volunteer mentors: a systematic review.

    Science.gov (United States)

    Smith, Raymond; Greenwood, Nan

    2014-02-01

    This systematic review aims to examine the differences and similarities between the various types of volunteer mentoring (befriending, mentoring and peer support) and to identify the benefits for carers and volunteers. Literature searching was performed using 8 electronic databases, gray literature, and reference list searching of relevant systematic reviews. Searches were carried out in January 2013. Four studies fitted the inclusion criteria, with 3 investigating peer support and 1 befriending for carers. Quantitative findings highlighted a weak but statistically significant (P =.04) reduction in depression after 6 months of befriending. Qualitative findings highlighted the value carers placed on the volunteer mentors' experiential similarity. Matching was not essential for the development of successful volunteer mentoring relationships. In conclusion, the lack of need for matching and the importance of experiential similarity deserve further investigation. However, this review highlights a lack of demonstrated efficacy of volunteer mentoring for carers of people with dementia.

  2. Psychological characteristics of Swedish mandatory enlisted soldiers volunteering and not volunteering for international missions: an exploratory study.

    Science.gov (United States)

    Rydstedt, Leif W; Osterberg, Johan

    2013-04-01

    The purpose of this study was to assess personality traits, psychological fitness, and hardiness among conscript soldiers volunteering for international missions (n = 146), by comparing them with conscripts from the same year class and unit who did not apply for international missions (n = 275). The sample consisted of all mandatory enlisted soldiers assigned to a supply and maintenance regiment. There were no demographic differences between the groups. The volunteers reported greater stress tolerance, concern for others, extraversion, and self-confidence than the non-volunteers. There were no differences between the groups in orderliness, temper instability, or independence. Volunteers repeatedly reported greater psychological fitness for military missions and greater hardiness over the period of military service compared to the non-volunteers.

  3. Synergy of Volunteer Measurements and Volunteer Computing for Effective Data Collecting, Processing, Simulating and Analyzing on a Worldwide Scale

    CERN Document Server

    Gordienko, Nikita; Fedak, Gilles; Gordienko, Yuri

    2015-01-01

    The paper concerns the hype idea of "Citizen Science" and the related paradigm shift: to go from the passive "volunteer computing" to other volunteer actions like "volunteer measurements" under guidance of scientists. They can be carried out by ordinary people with standard computing gadgets (smartphone, tablet, etc.) and the various standard sensors in them. Here the special attention is paid to the system of volunteer scientific measurements to study air showers caused by cosmic rays. The technical implementation is based on integration of data about registered night flashes (by radiometric software) in shielded camera chip, synchronized time and GPS-data in ordinary gadgets: to identify night "air showers" of elementary particles; to analyze the frequency and to map the distribution of "air showers" in the densely populated cities. The project currently includes the students of the National Technical University of Ukraine "KPI", which are compactly located in Kyiv city and contribute their volunteer measur...

  4. 我军现役人员口腔健康现状的变化和发展%Prevalence of caries and periodontal diseases among Chinese male military personnel: a 15 year longitudinal study

    Institute of Scientific and Technical Information of China (English)

    郭静; 李刚; 王胜朝; 胡轶; 杨文晔; 刘芸; 王娟娟; 吉兆华

    2012-01-01

    目的:调查15年期间我军男性现役人员龋病、牙周病的流行状况和变化趋势.方法:1993、2008年利用抽样调查方法、2003年利用捷径调查方法对全军具有代表性的陆军、海军、空军等军种男性现役人员的龋病、牙周疾病状况进行口腔健康检查.结果:15年期间我军的龋病、牙周疾病的患病率和强度显著下降,海军龋齿患病率和活动性龋病高于陆军和空军.结论:15年期间我军男性现役人员口腔健康状况稳步提高,还需进一步改善海军的口腔卫生勤务保障能力.%ABM: To investigate the prevalence of caries and periodontal diseases among armed forces in China during fifteen years. METHODS; Male active duty armed forces personnel in China were examined for dental caries and periodontal diseases using sampling survey or pathfinder survey method in 1993, 2003 and 2008. RESULTS: Prevalence rate and intensity of dental caries and periodontal diseases of male active duty armed forces personnel decreased significantly during the fifteen years examined. Prevalence of dental caries in navy was higher than that in other armed forces. CONCLUSION: Oral health of male active duty armed forces personnel in China improves steadily, yet dental services in navy need to be further improved.

  5. Male pattern baldness

    Science.gov (United States)

    Alopecia in men; Baldness - male; Hair loss in men; Androgenetic alopecia ... Male pattern baldness is related to your genes and male sex hormones. It usually follows a pattern of receding hairline and ...

  6. The impact of selective and non-selective non-steroid anti-inflammatory drugs on secondary hemostasis in healthy volunteers

    DEFF Research Database (Denmark)

    Schjerning, Ole; Larsen, Torben B; Damkier, Per

    2009-01-01

    inhibitors could affect the secondary hemostasis and by that increase the risk of cardiovascular events in a population at high risk. METHODS: An open-label randomized cross-over study was performed in 20 healthy male volunteers. The study consisted of two periods of each 21 days with medication, either...

  7. Development of Chinese adult male mathematical phantom and external radiation dose calculations%中国数字人体男性数学模型建立及外辐射模拟

    Institute of Scientific and Technical Information of China (English)

    孙文娟; 谢添武; 韩道; 刘谦

    2013-01-01

    基于“中国数字人男一号”高分辨人体结构数据集,通过最小包围盒方法获取中国数字人体男性体素模型各器官空间位置和尺寸信息,建立了中国数字人体男性数学模型,并通过变形实现了不同身高模型的构建.采用蒙特卡罗方法进行了不同能量下光子中子的外部辐射模拟.通过结果对比发现,数学模型与体素模型模拟结果趋势一致,但器官位置和质量对剂量影响较大,低能级下尤为明显.对于不同身高模型,小型个体剂量大于大型个体,深层器官剂量较浅层器官对器官尺寸更为敏感.数学模型定义简单,存储空间小,有利于人体辐射剂量的快速计算.%A new mathematical phantom, the Chinese MIRD (CMIRD), was developed based on the high-resolution data set of Visible Chinese Human (VCH). The position and size of organs were obtained from the voxel-based VCH model, using the minimal 3D bounding box method. According to the equations of the ORNL adult phantom, the original CMIRD based on that anatomic information was constructed and the method of proportional deformation was adopted in order to compare the external radiation dose of different height models for different radiation directions and particles with MCNPX. The stimulation results obtained from CMIRD present comparable to those published dose values. The analysis of the discrepancies indicates that the shape, location and mass of organs have great influence on radiation dose especially at low energies. The comparison of the effective doses for models with different size shows that the size of the model is important, and the smaller models receive larger doses. Also, the deeper organs present more sensitive to the organ size than the shallower ones. In addition, the mathematical model is superior in speed of the radiation dose calculation, which requires simpler definition and less memory space.

  8. Effects of tai chi qigong on psychosocial well-being among hidden elderly, using elderly neighborhood volunteer approach: a pilot randomized controlled trial

    OpenAIRE

    Chan AW; Yu DS; Choi KC

    2017-01-01

    Aileen WK Chan, Doris SF Yu, KC Choi The Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR Purpose: To test the feasibility and preliminary effectiveness of a tai chi qigong program with the assistance of elderly neighborhood volunteers in strengthening social networks and enhancing the psychosocial well-being of hidden elderly. Patients and methods: “Hidden elderly” is a term used to describe older adults w...

  9. Chinese Dream

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    The general managers of South Korean auto giants Hyundai and Kia have high hopes for the growing Chinese auto market. Both companies went through a painstaking period as the financial crisis first roared across the globe. Jin Shan-fa, General Manager of Hyundai Motor Group

  10. Genetic and environmental influences on Chinese language and reading abilities

    OpenAIRE

    Bonnie Wing-Yin Chow; Connie Suk-Han Ho; Simpson Wai-Lap Wong; Waye, Mary M. Y.; Bishop, Dorothy V M

    2011-01-01

    This study investigated the etiology of individual differences in Chinese language and reading skills in 312 typically developing Chinese twin pairs aged from 3 to 11 years (228 pairs of monozygotic twins and 84 pairs of dizygotic twins; 166 male pairs and 146 female pairs). Children were individually given tasks of Chinese word reading, receptive vocabulary, phonological memory, tone awareness, syllable and rhyme awareness, rapid automatized naming, morphological awareness and orthographic s...

  11. Effects of chlorophyll and chlorophyllin on low-dose aflatoxin B(1) pharmacokinetics in human volunteers.

    Science.gov (United States)

    Jubert, Carole; Mata, John; Bench, Graham; Dashwood, Roderick; Pereira, Cliff; Tracewell, William; Turteltaub, Kenneth; Williams, David; Bailey, George

    2009-12-01

    Chlorophyll (Chla) and chlorophyllin (CHL) were shown previously to reduce carcinogen bioavailability, biomarker damage, and tumorigenicity in trout and rats. These findings were partially extended to humans, where CHL reduced excretion of aflatoxin B(1) (AFB(1))-DNA repair products in Chinese unavoidably exposed to dietary AFB(1). However, neither AFB(1) pharmacokinetics nor Chla effects were examined. We conducted an unblinded crossover study to establish AFB(1) pharmacokinetic parameters among four human volunteers, and to explore possible effects of CHL or Chla cotreatment in three of those volunteers. For protocol 1, fasted subjects received an Institutional Review Board-approved dose of 14C-AFB(1) (30 ng, 5 nCi) by capsule with 100 mL water, followed by normal eating and drinking after 2 hours. Blood and cumulative urine samples were collected over 72 hours, and 14C- AFB(1) equivalents were determined by accelerator mass spectrometry. Protocols 2 and 3 were similar except capsules also contained 150 mg of purified Chla or CHL, respectively. Protocols were repeated thrice for each volunteer. The study revealed rapid human AFB(1) uptake (plasma k(a), 5.05 + or - 1.10 h(-1); T(max), 1.0 hour) and urinary elimination (95% complete by 24 hours) kinetics. Chla and CHL treatment each significantly impeded AFB(1) absorption and reduced Cmax and AUCs (plasma and urine) in one or more subjects. These initial results provide AFB(1) pharmacokinetic parameters previously unavailable for humans, and suggest that Chla or CHL co-consumption may limit the bioavailability of ingested aflatoxin in humans, as they do in animal models.

  12. Improving remote sensing flood assessment using volunteered geographical data

    Directory of Open Access Journals (Sweden)

    E. Schnebele

    2013-03-01

    Full Text Available A new methodology for the generation of flood hazard maps is presented fusing remote sensing and volunteered geographical data. Water pixels are identified utilizing a machine learning classification of two Landsat remote sensing scenes, acquired before and during the flooding event as well as a digital elevation model paired with river gage data. A statistical model computes the probability of flooded areas as a function of the number of adjacent pixels classified as water. Volunteered data obtained through Google news, videos and photos are added to modify the contour regions. It is shown that even a small amount of volunteered ground data can dramatically improve results.

  13. The headache-inducing effect of cilostazol in human volunteers

    DEFF Research Database (Denmark)

    Birk, S; Kruuse, Christina; Petersen, K.A.;

    2006-01-01

    healthy volunteers were included in a double-blind, randomized, crossover study. Placebo or cilostazol (200 mg p.o.) was administered on two separate study days. Headache was scored on a verbal rating scale (0-10) and mechanical pain thresholds were measured with von Frey hairs. The median peak headache...... score 0-16 h postdose was 0 (range 0-2) after placebo and 3.5 (range 0-7) after cilostazol (P = 0.003). The median headache curve peaked at 6-9 h postdose. The headaches induced were usually bilateral and pulsating. Nausea occurred in two volunteers, photo- and phonophobia were not seen. Two volunteers...

  14. Volunteering in the maternity services: for whose benefit?

    Science.gov (United States)

    Hall, Jennifer

    2013-01-01

    In recent years volunteers have become part of the maternity services to support midwives in the UK. Future midwifery students are being expected to have gained such experience when applying for courses. They are providing significant support for women in relation to breastfeeding and in other supportive roles. However this article aims to explore what volunteers are doing, questions whether the recent shortage of midwives is leading to volunteers being asked to take on tasks that are beyond their unpaid status and asks who is really benefiting from this role.

  15. Influence of Youth Volunteering on Socialization and Development of Competences

    Directory of Open Access Journals (Sweden)

    Valdas Pruskus

    2014-06-01

    Full Text Available Volunteering is one of manifestations of citizenship. It indicates the individual’s quality in terms of citizenship and the readiness to take an active part in public activities. The current paper analyses the phenomenon of volunteering (its place and role in ensuring public development and sustainability. The influence of volunteer - ing on the youth socialization and personal development of competences (in particular, social, professional and communicative is disclosed in the article. The article also highlights the motives and factors that promote and prevent the youth participation in voluntary activities.

  16. ATLAS@Home: Harnessing Volunteer Computing for HEP

    CERN Document Server

    Cameron, David; The ATLAS collaboration

    2015-01-01

    The ATLAS collaboration has setup a volunteer computing project called ATLAS@home. Volunteers running Monte-Carlo simulation on their personal computer provide significant computing resources, but also belong to a community potentially interested in HEP. Four types of contributors have been identified, whose questions range from advanced technical details to the reason why simulation is needed, how Computing is organized and how it relates to society. The creation of relevant outreach material for simulation, event visualization and distributed production will be described, as well as lessons learned while interacting with the BOINC volunteers community.

  17. Antithrombin III: biodistribution in healthy volunteers.

    Science.gov (United States)

    Knot, E A; de Jong, E; ten Cate, J W; Gie, L K; van Royen, E A

    1987-12-18

    Five healthy volunteers were injected intravenously with 73-90 uCi purified human 131I-Antithrombin III (AT III), specific biological activity 5.6 U/mg. The tracer data were analysed using a three compartment model. The plasma radioactivity half life was 66.2 +/- 1.2 (sem) h, the fractional catabolic rate constant of the plasma pool was 0.025 +/- 0.002 (sem) h-1. These data were comparable with those described in the literature. Because of the difficulty in translating the mathematical analysis of various compartments into the biological model, biodistribution was monitored by a gamma camera linked to a DEC PDP 11/34 computer system. Dynamic and static images were obtained at fixed time intervals following the injection of 131I-AT III. Whole body scanning at intervals between the time of injection (t = 0) and t = 24.5 h showed 131I-AT III distribution over the heart, lungs, liver, spleen and great vessels. Dynamic scanning was performed over the heart, spleen and liver. Overlayed frames in the first ten minutes after the 131I-AT III injection showed the following radioactivity expressed as percentage of the injected dose; 5.9% +/- 0.3 (sem) over the heart, 10.6% +/- 0.9 (sem) over the liver and 1.1% +/- 0.1 (sem) over the spleen. A slower decline of the radioactivity between t = 0 and t = 24 h; (19%) was measured over the liver compared with the radioactivity disappearance over the heart region. This shows, in combination with the fact that the radioactivity disappearance over the heart was identical with the radioactivity decline measured in the plasma samples that retention of 131I-AT III occurred in the liver.(ABSTRACT TRUNCATED AT 250 WORDS)

  18. Pharmacogenetics of healthy volunteers in Puerto Rico.

    Science.gov (United States)

    Claudio-Campos, Karla; Orengo-Mercado, Carmelo; Renta, Jessicca Y; Peguero, Muriel; García, Ricardo; Hernández, Gabriel; Corey, Susan; Cadilla, Carmen L; Duconge, Jorge

    2015-12-01

    Puerto Ricans are a unique Hispanic population with European, Native American (Taino), and higher West African ancestral contributions than other non-Caribbean Hispanics. In admixed populations, such as Puerto Ricans, genetic variants can be found at different frequencies when compared to parental populations and uniquely combined and distributed. Therefore, in this review, we aimed to collect data from studies conducted in healthy Puerto Ricans and to report the frequencies of genetic polymorphisms with major relevance in drug response. Filtering for healthy volunteers or individuals, we performed a search of pharmacogenetic studies in academic literature databases without limiting the period of the results. The search was limited to Puerto Ricans living in the island, excluding those studies performed in mainland (United States). We found that the genetic markers impacting pharmacological therapy in the areas of cardiovascular, oncology, and neurology are the most frequently investigated. Coincidently, the top causes of mortality in the island are cardiovascular diseases, cancer, diabetes, Alzheimer's disease, and stroke. In addition, polymorphisms in genes that encode for members of the CYP450 family (CYP2C9, CYP2C19, and CYP2D6) are also available due to their relevance in the metabolism of drugs. The complex genetic background of Puerto Ricans is responsible for the divergence in the reported allele frequencies when compared to parental populations (Africans, East Asians, and Europeans). The importance of reporting the findings of pharmacogenetic studies conducted in Puerto Ricans is to identify genetic variants with potential utility among this genetically complex population and eventually move forward the adoption of personalized medicine in the island.

  19. A lateral cephalometric study of sella turcica in Southern Chinese

    OpenAIRE

    Mohamed Makhbuol, MZB; Wong, RWK; Rabie, ABM

    2012-01-01

    The dimensions of sella might be associated with pathological conditions, yet data related to these are scanty. This study is to quantitatively investigate the dimensions of sella in southern Chinese population. This retrospective pilot study consists 150 randomly selected Chinese lateral cephalometric radiographs (50 females and 100 males) presented to PPDH for Orthod...

  20. Study of Histological Mechanism of Lost Bone of Male Rats Eunuch Prevented and Treated by Chinese Herb Tonifying Kidney%补肾中药防治去睾大鼠骨丢失的组织学机理研究

    Institute of Scientific and Technical Information of China (English)

    黄海; 成羿; 朱杭; 陈红梅; 章煜铭

    2001-01-01

    To study the histological mechanism of the lost bone of male rats eunuch prevented and treated by Chinese herb tonifying kidney. Methods:Selecting ten-month old male rats as pathological model. Whose testicles have been cut away, then dividing them into three groups as the following: normal group, pathological group, Chinese herb tonifying kidney group. After feeding them drugs for 12 weeks. We kill them and choose L1 and L2 to make bone slices without decalcification, meanwhile, determinate diverse bone indexes and superficial indexes of bone morphological metrology and make ANOVA. Results: ①AII bone indexes in the pathological group are smaller than that in normal one (P<0.05). All superficial index prove: osteoclast index decrease; osteoblast index increase, bone transformation become faster than before. ②)All bone indexes of Chinese herb tonifying kidney group are higher than that of pathological group (P<0.05). The superficial indexes are reversed, some osteoblastic cells are particularly active, under which bonemoid substance stands out from the peripheral static superface. Conclusions: Chinese herb tonifying kidney has three aspects of histological mechanism to prevent and treat senile osteoporosis: ①double effects of restraining bone absorption and promoteing bone formation, ②reduce bone transformation, improve bone quality, ③the short circuit effect during bone reconstruction.%目的:探讨补肾中药防治去睾大鼠骨丢失的组织学机理。方法:选用10月龄大鼠行去睾术作为病理模型。分组为:正常组、病理组和补肾中药组。用药12周后处死取腰1~2脊椎,作不脱钙骨切片,测定骨形态计量学各骨量参数和表面参数。各组参数作方差分析,显著性检验。结果:①病理组骨量参数小于正常组(P<0.05);表面参数显示:成骨参数减少、破骨参数增加、骨转换加快(P<0.05)。②补肾中药组骨量参数高于病理组(P<0.05);表