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Sample records for chinese male volunteers

  1. Effect of tamsulosin on the pharmacokinetics of dutasteride in Chinese male healthy volunteers.

    Science.gov (United States)

    Li, Huafang; Yang, Jiansong; Zhao, Hongxin; Fossler, Michael J; Wang, Chunrong

    2015-11-01

    The purpose of this study was to evaluate the effect of tamsulosin (0.2 mg) on the pharmacokinetics of dutasteride (0.5 mg) in a group of healthy Chinese male volunteers. This was an open-label, single-sequence, 3-period, drug-drug interaction phase 1 study. Twenty-four healthy Chinese male volunteers were enrolled and administered a single dose of 0.5 mg dutasteride and, following a 28- to 30-day washout period, 0.2 mg tamsulosin once daily for 7 days. On day 5, subjects received 0.2 mg tamsulosin coadministered with 0.5 mg dutasteride. Serum dutasteride and tamsulosin concentrations were monitored. In the presence or absence of tamsulosin, there were no apparent changes in dutasteride AUC and Cmax . Adverse events reported were mild to moderate in intensity and resolved by the end of the study. In healthy Chinese male volunteers, tamsulosin 0.2 mg at steady state had no apparent effect on dutasteride pharmacokinetics. Dutasteride and tamsulosin when administered alone or in combination were well tolerated. PMID:27137714

  2. Comparative fasting bioavailability and pharmacokinetic properties of 2 formulations of glucosamine hydrochloride in healthy Chinese adult male volunteers.

    Science.gov (United States)

    Wu, H; Liu, M; Wang, S; Zhao, H; Yao, W; Feng, W; Yan, M; Tang, Y; Wei, M

    2012-08-01

    Glucosamine (CAS 66-84-2) hydrochloride is an amino monosaccharide indicated for the treatment of arthrosis, especially osteoarthritis of the knee joint. This study was conducted to assess and compare the pharmacokinetic (PK) properties, bioavailability of a newly developed dispersible tablet formulation (test) of glucosamine hydrochloride with those of an established branded capsule formulation (reference) in healthy Chinese adult male volunteers.This single-dose, randomized, open-label, 2-period crossover study was conducted in 18 healthy Chinese adult male volunteers under fasting condition. Plasma samples were collected at pre-specified times over a 12-h period following administration in each period and analyzed the plasma glucosamine concentrations by Liquid Chromatography coupled with Tandem Mass Spectrometry (LC/MS/MS) method. The mean (SD) PK parameters of Cmax, Tmax, AUC0-12, and AUC0-∞ after administration of the test and reference formulations were, respectively, as follows: Cmax, 907.01 (444.22) vs. 944.40 (429.89) ng/mL, Tmax, 3.03 (0.95) vs. 3.30 (0.99) hours, AUC0-12, 2891.41 (1352.30) vs. 2889.69 (925.48) ng/mL/h, and AUC0-∞, 3029.90 (1321.36) vs. 3091.87 (870.36) ng/mL/h. The mean (SD) t1/2 was 1.10 (0.52) hours for the test formulation and 1.50 (1.17) hours for the reference formulation. On ANOVA, neither period nor sequence effects were observed for any PK properties. The relative bioavailability of the test formulation was 98.3% assessed by AUC0-12. The 90% CIs of glucosamine for the log-transformed ratios of Cmax, AUC0-12, and AUC0-∞ were 78.4-113.9%, 80.8-108.5% and 80.8-105.8%, respectively, meeting the predetermined criteria for bioequivalence of SFDA. PMID:22791244

  3. Pharmacokinetics and bioequivalence of lorazepam tablets in Chinese healthy volunteers

    Institute of Scientific and Technical Information of China (English)

    Xiang-junQIU; Guo-xinHU; Jian-gangWANG; Zong-shunDAI

    2004-01-01

    AIM: To study the pharmacokinetics and bioequivalence of lorazepam tablets in Chinese healthy volunteers. METHODS:Twenty Chinese healthy male volunteers were involved in the study. Each subject received a single dose of 3 mg Lorazepam tested formulation (T, Hubei Zhongtian Airbeck Pharmaceutical Limited Company) or Lorazepam reference formulation (R, Thailand Atlatic Pharmaceutical Limited Company) with a random-

  4. Pharmacokinetics and Bioequivalence of Two Formulations of Febuxostat 40-Mg and 80-Mg Tablets: A Randomized, Open-Label, 4-Way Crossover Study in Healthy Chinese Male Volunteers

    Science.gov (United States)

    Luo, Zhu; Nan, Feng; Miao, Jia; Chen, Zhihui; Li, Mei; Liang, Maozhi

    2016-01-01

    The present study aimed to investigate the pharmacokinetic properties of febuxostat in healthy Chinese male volunteers and evaluate whether the two formulations of febuxostat 40-mg and 80-mg tablets are bioequivalent. A randomized, open-label, 4-way crossover study was conducted in healthy Chinese male volunteers under fasting conditions. 24 eligible subjects were randomized in a 1:1:1:1 ratio to receive a single dose of test or reference formulation of febuxostat 40-mg or 80-mg tablet. The washout period between each administration was 1 week. Plasma febuxostat was quantified by a validated liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. Tolerability was evaluated by monitoring adverse events, physical examinations, 12-lead ECG and laboratory tests. After single-dosing of 1 tablet of 40-mg febuxostat, the pharmacokinetic parameters of test and reference formulations were: Tmax 1.22±0.87 and 1.85±1.03 h, Cmax 1689.16±461.31 and 1613.80±608.43 ng·mL-1, AUC0-t 5139.87±1349.28 and 5517.91±2024.26 ng·mL-1·h, AUC0−∞ 5263.06±1339.16 and 5640.48±2040.22 ng·mL-1·h, t1/2 4.82±2.61 and 4.85±1.78 h, respectively. After single-dosing of 1 tablet of 80-mg febuxostat, the pharmacokinetic parameters of test and reference formulations were: Tmax 1.71±1.21 and 2.23±1.55 h, Cmax 2744.47±1157.44 and 2998.17±1200.13 ng·mL-1, AUC0-t 9634.03±2768.25 and 10467.95±3501.65 ng·mL-1·h, AUC0−∞ 9834.32±2730.51 and 10626.63±3504.08 ng·mL-1·h, t1/2 6.25±2.44 and 5.46±1.65 h, respectively. For single-dosing of 1 tablet of 40-mg febuxostat, 90% CIs for the test/reference ratio of AUC0-t, AUC0−∞ and Cmax were 89.79 to 102.55, 90.14 to 102.56 and 93.99 to 129.63, respectively. For single-dosing of 1 tablet of 80-mg febuxostat, 90% CIs for the test/reference ratio of AUC0-t, AUC0−∞ and Cmax were 86.67 to 100.00, 87.50 to 100.51 and 79.48 to 105.99, respectively. This single dose study revealed similar pharmacokinetic properties in

  5. Bioequivalent Evaluation of Two Brands of Losartan/Hydrochlorothiazide Compound Tablets in Healthy Chinese Male Volunteers%两种氯沙坦/氢氯噻嗪复方片剂的人体生物等效性评价

    Institute of Scientific and Technical Information of China (English)

    杨平; 李琳; 孙进; 何仲贵

    2006-01-01

    目的 评价两种氯沙坦/氢氯噻嗪(50 mg/12.5 mg)复方片剂在中国男性健康志愿者体内的生物等效性.方法 本研究采用随机、开放、双周期交叉设计,洗净期为7天.20名男性健康志愿者先后单剂量口服氯沙坦/氢氯噻嗪(50 mg/12.5 mg)受试及参比制剂.血药浓度由已确证的HPLC-ESI-MS法测定.结果 双单侧检验结果显示,氯沙坦的AUC0-12及Cmax的90%置信区间分别为86% - 112%及89% - 134%,氢氯噻嗪分别为85% - 100%及75% - 102%,均在中国药典所规定的可接受范围内.结论 两种速释氯沙坦/氢氯噻嗪复方片剂生物等效.%Aim To evaluate the bioequivalence of two brands of losartan/hydrochlorothiazide (50 mg/12.5 mg) compound tablets in healthy Chinese male volunteers. Methods An open, randomized, single-dose, two-period cross-over study with a wash-out period of 7 d was conducted. Twenty healthy male volunteers were given a single dose 50 mg losartan/12.5 mg hydrochlorothiazide of either test (T) or reference (R) compound tablets, respectively. Blood samples were collected up to 48 h after oral administration. The concentrations of losartan and hydrochlorothiazide in plasma were determined by a validated HPLC-ESI-MS method. Results In the case of losartan, the 90% confidence intervals of two one-side test for percent ratios with a significant level (α) of 0.05 were 86% - 112% for AUC0-12 and 89% - 134% for Cmax, respectively, which were within the interval proposed in the Chinese Pharmacopoeia, 80% - 125% of AUC and 70% - 143% of Cmax, respectively. Similarly, the 90% confidence intervals for percent ratios were 85% - 100% and 75% - 102% for hydrochlorothiazide, both of which fell into the accepted interval. Conclusion Two immediate-release compound tablets of losartan/hydrochlorothiazide are bioequivalent from a statistical standpoint in the extent and rate of absorption from the single-dose study in healthy Chinese male volunteers.

  6. BIOAVAILABILITY AND PHARMACOKINETICS OF ANASTROZOLE IN HEALTHY MALE VOLUNTEERS

    Institute of Scientific and Technical Information of China (English)

    安富荣; 崔岚; 刘晓琰; 王平全; 祝德秋; 曹惠明

    2002-01-01

    Objective To evaluate bioavailability and pharmacokinetics of domestic and imported anastrozole tablets. Methods Twenty Chinese healthy male volunteers were enrolled in a randomized crossover study with a single oral dose of 2mg of the two formulations respectively. The anastrozole in plasma was measured by gas chromatography with electron-capture detection. The linear range was 1. 325 ~ 106ng /ml plasma. The extraction recovery rates for plasma concentration of 5.3, 21.2 and 53. Ong/ml were 76.8% ,87.0% and 78.7%, respectively. Inter-day and intra-day precisions of the method were < 9%. Area under concentration-time curve ( AUCo t) , maximum plasma concentration (Cmax) and reach peak time (Tmax) were evaluated by variance analysis and two one-side t-test . Results A two-compartment model was adopted in anastrozole plasma concentration-time data analysis. The main pharmacokinetic parameters of domestic and imported anastrozloe tablets such as Cmax , Tmax, AUCo - t and T1/2β were (36.5 ± 6.9)ng/ml and (35.6 ± 9.4)ng/ml, (1.56-±0.41)hand(1.53 ±0.49)h, (1403.6 ± 321.2)ng'h/mland (1371.6±329.4)ng'h/mi, (42.57 ± 10.15)h and (43.41 ± 8.59)h, respectively, and there were no significant differences between the two formulations. Conclusion Domestic and imported anastrozole tablets were of bioequivalence.The relative bioavailability of the domestic tablet was (102.7 ± 5.6)%.

  7. Pharmacokinetics of ambroxol and clenbuterol tablets in healthy Chinese volunteers

    OpenAIRE

    Yang, Yong-Ge; Song, Li-Xue; Jiang, Nan; Xu, Xue-Ting; Di, Xiao-Hui; Zhang, Mei

    2015-01-01

    Objective: To investigate the pharmacokinetics of Ambroxol and Clenbuterol Tablets in Chinese healthy volunteers after a single or multiple dosages oral administration. Methods: A total of 9 healthy adult subjects were given Ambroxol and Clenbuterol Tablets in a single dosage or multiple dosages respectively. LC/MS/MS were used for the determination of Ambroxol and Clenbuterol of in plasma. The important pharmacokinetic parameters were calculated by DAS 2.0 software (compartment model). Resul...

  8. Bioequivalence Study of Donepezil Hydrochloride Tablets in Healthy Male Volunteers

    OpenAIRE

    Supanimit Teekachunhatean; Sukit Roongapinun; Nutthiya Hanprasertpong; Siriluk Aunmuang; Noppamas Rojanasthien

    2012-01-01

    The objective of this study was to investigate the bioequivalence of two formulations of 5 mg donepezil HCL tablets: Tonizep as the test and Aricept as the reference. The two products were administered as a single oral dose according to a randomized two-phase crossover with a 3-week washout period in 20 healthy Thai Male volunteers. After drug administration, serial blood samples were collected over a period of 216 hours. Plasma donepezil concentrations were measured by high performance liqui...

  9. Population pharmacokinetics of olprinone in healthy male volunteers

    Directory of Open Access Journals (Sweden)

    Kunisawa T

    2014-03-01

    Full Text Available Takayuki Kunisawa,1 Hidefumi Kasai,2 Makoto Suda,2 Manabu Yoshimura,3 Ami Sugawara,3 Yuki Izumi,3 Takafumi Iida,3 Atsushi Kurosawa,3 Hiroshi Iwasaki3 1Surgical Operation Department, Asahikawa Medical University Hospital, Hokkaido, Japan; 2Clinical Study Management Division, Bell Medical Solutions Inc, Tokyo, Japan; 3Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical University, Hokkaido, Japan Background: Olprinone decreases the cardiac preload and/or afterload because of its vasodilatory effect and increases myocardial contractility by inhibiting phosphodiesterase III. Purpose: The objective of this study was to characterize the population pharmacokinetics of olprinone after a single continuous infusion in healthy male volunteers. Methods: We used 500 plasma concentration data points collected from nine healthy male volunteers for the study. The population pharmacokinetic analysis was performed using the nonlinear mixed effect model (NONMEM® software. Results: The time course of plasma concentration of olprinone was best described using a two-compartment model. The final pharmacokinetic parameters were total clearance (7.37 mL/minute/kg, distribution volume of the central compartment (134 mL/kg, intercompartmental clearance (7.75 mL/minute/kg, and distribution volume of the peripheral compartment (275 mL/kg. The interindividual variability in the total clearance was 12.4%, and the residual error variability (exponential and additive were 22.2% and 0.129 (standard deviation. The final pharmacokinetic model was assessed using a bootstrap method and visual predictive check. Conclusion: We developed a population pharmacokinetic model of olprinone in healthy male adults. The bootstrap method and visual predictive check showed that this model was appropriate. Our results might be used to develop the population pharmacokinetic model in patients. Keywords: phosphodiesterase III inhibitor, men, pharmacokinetic model

  10. Fluorescence detection of tramadol in healthy Chinese volunteers by high-performance liquid chromatography and bioequivalence assessment

    OpenAIRE

    Zhou X; Liu J

    2015-01-01

    Xiao Zhou, Ji Liu Department of Anesthesia, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China Abstract: This study developed a revised high-performance liquid chromatography fluorescence method to determine plasma tramadol concentration, and thereby to examine the bioequivalence of two tramadol formulations among healthy male Chinese volunteers. The study used a double-blind, randomized, 2×2 crossover-design principle. Calculat...

  11. Safety of a New Compact Male Intermittent Catheter: Randomized, Cross-Over, Single-Blind Study in Healthy Male Volunteers

    DEFF Research Database (Denmark)

    Bagi, Per; Hannibalsen, Jane; Permild, Rikke; Stilling, Sine; Looms, Dagnia K

    2011-01-01

    Introduction: A new compact male intermittent catheter was compared with a regular intermittent male catheter in terms of safety and acceptability. Methods: In this randomized, single-blind, cross-over study, healthy male volunteers were catheterized twice with a compact catheter and twice with a...

  12. The study of bioavailability and bioequivalence of oseltamivir in Chinese health volunteers

    Institute of Scientific and Technical Information of China (English)

    LI Jing-lai; CUI Meng-cun; WANG Xiao-ying; QIAO Jian-zhong; YUAN Su-lan; ZHANG Zhen-qing; RUAN Jin-xiu; ZHONG Wu; LI Song

    2008-01-01

    Objective To evaluate the bioavailability and bioequivalence of oseltamivir capsule in Chinese health male volunteers. Methods A randomized, two period, two treatment, two sequence crossover bioequivalence trial was designed, 24 Chinese health volunteers were randomly divided into two groups, each group was orally given single dose oseltamivir phosphate (tamifla) or AMMS 607 capsule. The active metabolite oseltamivir carboxylate of oseltamivir in the plasma were determined by liquid chromatographic-tandem mass spectrometric (LC-MS/MS) method. The pharmacokinetics parameters and relative bioavailability were calculated to evaluate the bioequivalence of AMMS 607 and tamifla. Results Cmax of the AMMS 607 and tamifla were 602.07±153.27 ng·mL-1 and 620.09±132.39 ng·mL-1 respectively; tmax were 4.2± 1.1 h and 4.8±1.0 h; t1/2β were 6.60±0.87 h and 6.61±0.83 h;MRT were 10.00±1.77 h and 10.40 ±1.62 h; AUC0-24 were 6285.88±1083.66 ng·h·mL-1 and 6546.01±1199.32 ng·h·mL-1; Compared with the reference of tamifla capsule, the bioavailability F0-tn of AMMS 607 capsule was 99.5±27.7 %. The main pharmacokinetics parameters of AUC0-24, Cmax and Tmax showed no statistically significant difference between the two capsules. Conclusions The AMMS 607 capsule and tamifla capsule are bioequivalent.

  13. Orally administered moxifloxacin prolongs QTc in healthy Chinese volunteers: a randomized, single-blind, crossover study

    OpenAIRE

    Chen, Qian; Liu, Yan-Mei; Liu, Yun; Mendzelevski, Boaz; Chanter, Dennis; Pu, Hua-hua; Liu, Gang-yi; Weng, Onglee; Hu, Chao-Ying; Wang, Wei; Yu, Chen; Jia, Jing-Ying

    2015-01-01

    Aim: To investigate the QT/QTc effects of orally administered moxifloxacin in healthy Chinese volunteers. Methods: This was a single-blinded, randomized, single-dose, placebo-controlled, two-period cross-over study. A total of 24 healthy Chinese volunteers were enrolled, randomly assigned to two groups: one group received moxifloxacin (400 mg, po) followed by placebo with a 7-d interval, another group received placebo followed by moxifloxacin with a 7-d interval. On the days of dosing, 12-lea...

  14. Pharmacokinetics of single-dose cefmetazole following intramuscular administration of cefmetazole sodium to healthy male volunteers.

    OpenAIRE

    Ko, H; Novak, E.; Peters, G R; Bothwell, W M; Hosley, J D; Closson, S K; Adams, W.J.

    1989-01-01

    The tolerance and pharmacokinetics of cefmetazole were studied in healthy male volunteers who received a placebo (sterile saline) or a single dose of cefmetazole sodium intramuscularly. Drug-treated volunteers received one of four doses, 0.375, 0.750, 1, or 2 g. The drug was well tolerated, with no adverse medical events or laboratory changes observed during the study that could affect the pharmacokinetic interpretation of the data. Cefmetazole concentrations were determined by using a specif...

  15. Developing an Older Adult Volunteer Program in a New York Chinese Community: An Evidence-Based Approach.

    Science.gov (United States)

    Mui, Ada C; Glajchen, Myra; Chen, Huajuan; Sun, Juanjuan

    2013-06-01

    This study reports the results of a pilot volunteer project for older Chinese immigrants and documents benefits for both volunteers and caregiver recipients. Using a social marketing approach, the volunteer project was designed as a social model to promote better health among older Chinese immigrants in New York City. The packaging of this health promotion project as a volunteer program was based on a strengths perspective. In the program, 18 older Chinese immigrants were trained to provide support and referral to family caregivers of ill relatives in the Chinese community. At 6 months, outcomes were evaluated for both volunteers and caregivers. The older volunteers perceived benefits associated with volunteering, specifically, a greater sense of well-being and satisfaction with life. In addition, the majority of volunteers felt empowered by training and volunteering (100 %), felt the skills they learned improved communication with their own families (90 %), and reported physical and emotional health benefits (61 %). At the same time, caregivers reported stress reduction following volunteer support. Findings suggest that a volunteer program model may be an effective health promotion intervention for older Chinese immigrants. PMID:23645945

  16. Immigrants as Active Citizens: Exploring the Volunteering Experience of Chinese Immigrants in Vancouver

    Science.gov (United States)

    Guo, Shibao

    2014-01-01

    Despite the fact that immigration has played an important role in transforming Canada into an ethno-culturally diverse and economically prosperous nation, immigrants themselves are often criticised as passive citizens. This study attempts to deconstruct this myth by investigating the volunteering experiences of Chinese immigrants in Vancouver. The…

  17. Pharmacokinetics of artemether and dihydroartemisinin in healthy Pakistani male volunteers treated with artemether-lumefantrine.

    OpenAIRE

    Tarning Joel; Najmi Muzammil H; Ali Shabana; Lindegardh Niklas

    2010-01-01

    Abstract Background Artemether-lumefantrine is one of the most widely used anti-malarial drug combinations in the world with excellent tolerability and cure rates in adult and paediatric patients with uncomplicated falciparum malaria. The aim of this study was to evaluate the pharmacokinetics of artemether and its active metabolite, dihydroartemisinin, in healthy Pakistani volunteers. Methods Twelve healthy male Pakistani subjects, aged 20 to 50, were recruited into the study. A fixed oral co...

  18. REPORT OF HLA DISTRIBUTION IN 2315 VOLUNTEER DONORS OF CHINESE BONE MARROW BANK FROM NORTHWEST CHINA

    Institute of Scientific and Technical Information of China (English)

    Jin Tianbo; Gao Ya; Zhang Hongbo; Zhao Junhai; Lai Jianghua; Lai Shuping; Li Shengbin

    2005-01-01

    Objective To report the HLA data of volunteer donors of Chinese bank from Northwest China and characterize the distribution of HLA genes in Northwest China. Methods HLA-A, B antigens of 2315 volunteer donors were examined by the method of microlymphocytetoxicity (MLT) test .The antigen frequencies(AF) were assessed by directly counting; and based on that gene frequencies(GF) were calculated. HLA data from other population were collected and distribution characteristics were compared. With the raw data, Hardy-Weinberg equilibrium, statistical parameters of forensic medicine interest for HLA were computed. Results A total of 18 specific antigens were detected in HLA-A and the most frequent antigen was A2 . AF and GF were 0.5136 and 0.3026, respectively. A total of 42 specific antigens were detected in HLA-B and the most frequent antigen was A13. Its AF and GF were 0.1978 and 0.1044, respectively. The heterozygosity(H), polymorphism information content(PIC), discrimination power(DP) and probability of paternity exclusion (PPE) of HLA-A were 0.8215, 0.8212, 0.9356 and 0.7798 accordingly; while H,PIC, DP and PPE of HLA-B were 0.9322, 0.9322, 0.9878 and 0.9528. Conclusion The polymorphism of HLA-A,B genes is characteristic in Chinese. In this research, the genetic trait of HLA in 2315 volunteers is consistent with Northern Han population.

  19. Sociocultural Influences on Body Image Concerns of Young Chinese Males

    Science.gov (United States)

    Jackson, Todd; Chen, Hong

    2008-01-01

    This research assessed the extent to which sociocultural factors implicated in explanations of weight dissatisfaction among young Western females extend to sources of body image concern in emerging adult and adolescent males from the People's Republic of China. In Study 1, 219 Mainland Chinese male university students completed measures of stature…

  20. Population pharmacokinetics and pharmacodynamics of bivalirudin in young healthy Chinese volunteers

    OpenAIRE

    Zhang, Dong-Mei; Wang, Kun; Zhao, Xia; Li, Yun-fei; Zheng, Qing-shan; Wang, Zi-ning; Cui, Yi-min

    2012-01-01

    Aim: To investigate the population pharmacokinetics (PK) and pharmacodynamics (PD) of bivalirudin, a synthetic bivalent direct thrombin inhibitor, in young healthy Chinese subjects. Methods: Thirty-six young healthy volunteers were randomly assigned into 4 groups received bivalirudin 0.5 mg/kg, 0.75 mg/kg, and 1.05 mg/kg intravenous bolus, 0.75 mg/kg intravenous bolus followed by 1.75 mg/kg intravenous infusion per hour for 4 h. Blood samples were collected to measure bivalirudin plasma conce...

  1. Acquirement of a new male sterile germplasm of Chinese jujube

    Institute of Scientific and Technical Information of China (English)

    WANG Jiurui; LIU Ling; LIU Mengjun; ZHOU Junyi

    2007-01-01

    A male sterile germplasm of Chinese jujube(Ziziphus jujuba Mill.),named 'male sterile No.1'(JMS1),was firstly identified from a natural population through studies of pollen amount and vitality and its anatomy.Its microspores got massed and then disaggregated after the tetrad stage during pollen development.Then its anthers became empty,or only pollen vestiges remained in the yellow buds.The pollen became abortive after the tetrad stage.Hypertrophy and hyperplasia of tapetum at the tetrad stage were related to pollen abortion.In view of its moderate could be used as a worthwhile female parent in the cross breeding of Chinese jujube.

  2. 阿托伐他汀在中国健康男性志愿者体内的药代动力学及生物等效性%Pharmacokinetics and bioequivalence of atorvastatin calcium tablets in healthy male Chinese volunteers

    Institute of Scientific and Technical Information of China (English)

    沈懿; 张逸凡; 陈笑艳; 郭丽霞; 钟大放

    2012-01-01

    healthy male Chinese volunteers after single oral administration.Methods This randomized sequence,open-label,two-period crossover study with a one-week washout period between doses was performed in 24 fasting healthy Chinese males.They were randomly assigned to receive 20 mg of either the test ( national made) or reference (imported) formulation orally.The blood samples were collected over a 72-hour period.Plasma concentrations of parent atorvastatin (AT),ortho-hydroxy-atorvastatin (o-OAT)and para-hydroxy-atorvastatin (p-OAT) were simultaneously determined using the validated liquid chromatography-tandem mass spectrometry method,the bioequivalence was also evaluated throughout the study.Results The main pharmacokinetic parameters of test and reference formulations were as follows:the values of Cmax for AT were ( 10.6 ± 11.9 ) μg/L and ( 10.6 + 9.8 ) μg/L,t1/2z were ( 11.4 ± 3.9 ) h and ( 11.4 ± 5.3 ) h,AUC0-t were (54.2 ± 37.4) μg · h - 1 · L- 1 and (51.7 ± 34.1 ) μg · h -1 · L- 1,respectively.The values of Cmax for o-OAT were (7.8 ±4.5) μg/L and (7.6 ±4.3) μg/L,t1/2z were (12.3 ±4.2) h and ( 11.9 ± 3.4) h,AUC0-t were (96.8 ± 48.2) μg · h - 1 · L- 1 and (92.3 ± 44.4) μg · h - 1 · L - 1,respectively.The values of Cmax for p-OAT were (0.5 ±+ 0.4 ) μg/L and (0.4 + 0.3 ) μg/L,t1/2z were ( 18.4 + 12.4 ) h and (23.3±17.8) h,AUC0-t were (15.9+12.3) μg· h-1 · L-1 and (13.8+8.11) μg· h-1 · L-1,respectively.The relative bioavailability of AT and o-OAT in test formulation were ( 105.3 ± 20.7 ) % and ( 107.8 ±23.2)%,respectively.The 90% confidence interval of the test/reference geometric mean ratios of AUC0-t for AT and o-OAT were (97.7 - 110.5)% and (98.3 - 111.3)%,Cmax for AT and o-OAT were (75.8- 114.0)% and (90.6 -122.9)%,they were all located within the bioequivalence criteria range (80% -125% for AUC,and 70% - 143% for Cmax ).Conclusion The result demonstrated that two formulations were bioequivalent.

  3. Pharmacokinetics and Pharmacodynamics of Intranasal Insulin Spray (Nasulin™) Administered to Healthy Male Volunteers:

    Science.gov (United States)

    Leary, Andrew C.; Dowling, Muiris; Cussen, Kathleen; O'Brien, Jackie; Stote, Robert M.

    2008-01-01

    Background The pharmacokinetics and pharmacodynamics of a Bentley Pharmaceuticals proprietary intranasal (IN) insulin formulation (Nasulin™) were studied in healthy volunteers. Methods Thirteen fasting healthy male volunteers received five doses of medication (one dose of 4 international units [IU] subcutaneous (SC) regular insulin and four doses of 25 IU IN insulin) at least 48 h apart. Serum insulin, serum C-peptide, and plasma glucose were measured in the 4 h after dosing. Profiles were compared for IN insulin spray following administration into the dominant nostril (more open at time of dosing) and into the nondominant nostril (less open at time of dosing). Results The formulation was generally well tolerated. A rise in serum insulin levels accompanied by a decrease in plasma glucose was seen following all doses. For IN doses, peak insulin levels were generally attained in 10–20 min and remained elevated for approximately 40–50 min; the resultant effect on glucose peaked at 40 min and waned approximately 2 h postdosing. As reported in other studies, the interindividual response to insulin was variable. The comparative absorption of IN insulin relative to SC insulin was 12.0% (dominant nostril) or 15.4% (nondominant nostril) over 2 h. This increased somewhat if sneezers and volunteers with moderately blocked nostrils were removed from the analysis. Conclusions This IN formulation was generally well tolerated and relatively well absorbed. While both insulin data (maximal plasma concentration and area under the plasma concentration time curve) and glucose data (% fall) support a trend toward better absorption from the nondominant nostril, this did not reach statistical significance. Nasulin can be administered without reference to the nasal cycle. PMID:19885293

  4. Bioequivalence of two recombinant granulocyte colony-stimulating factor formulations in healthy male volunteers.

    Science.gov (United States)

    Hernández-Bernal, Francisco; García-García, Idrian; González-Delgado, Carlos A; Valenzuela-Silva, Carmen; Soto-Hernández, Ramón; Ducongé, Jorge; Cervantes-Llano, Majel; Blanco-Garcés, Elizabeth; Rodríguez, Víctor; García-Vega, Yanelda; Bello-Rivero, Iraldo; Olivera-Ruano, Lourdes; López-Saura, Pedro

    2005-05-01

    To evaluate the equivalence of the pharmacokinetic, pharmacodynamic and safety properties of two recombinant G-CSF formulations in healthy male volunteers, a standard 2-way randomized crossover double-blind study, with a 3 week washout period, was conducted. A single 300 microg G-CSF dose was administered subcutaneously. Hebervital (Heber Biotec, Havana, formulation A) and Neupogen (Hoffmann-La Roche S.A, formulation B) were compared. Twenty-four healthy male volunteers were included. The serum G-CSF level was measured by enzyme immunoassay (EIA) during the first 36 h after administration. Absolute neutrophils (ANC), white blood cells (WBC) and CD34+ cells counts were the pharmacodynamic variables measured up to 120 h. Other clinical and laboratory determinations were used as safety criteria. The pharmacokinetic parameters for formulation A and B were very close to each other (i.e. AUC, 235.9 vs 270.0 ng.h/ml; C(max), 29.2 vs 33.4 ng/ml; T(max), 4.2 vs 4.7 h; half-life, 3.2 vs 2.8 h; CL, 260.9 vs 277.2 ml/h; V(d), 1.2 vs 1.1 l; and MRT, 7.58 vs 7.38 h). The confidence intervals for the means ratio of all these parameters were within or very close to the 0.8-1.25 acceptance range. The pharmacodynamics showed high similarity since ANC and WBC had the same profiles for both products and no differences were detected for the estimated parameters. The CD34+ cells count increments were evident for both formulations in a similar way as well. The treatments were well tolerated. Registered adverse events were similar; back/spine pain was the most frequent. According to the overall results these formulations could be considered as clinically comparable. PMID:15799006

  5. Pharmacokinetic study of inosiplex tablets in healthy Chinese volunteers by hyphenated HPLC and tandem MS techniques

    Institute of Scientific and Technical Information of China (English)

    Mo Chen; Yuan Zhang; Xiao-Ting Que; Ya Ding; Lin Yang; Ai-Dong Wen; Tai-Jun Hang

    2013-01-01

    Inosiplex is a compound formulation composed of inosine and p-acetaminobenzoic acid (PABA) salt of N,N-dimethylamino-2-propanol (DIP). This study was to investigate the clinical plasma pharmacokinetic properties of DIP and PABA after single and multiple oral doses of inosiplex tablets in healthy Chinese volunteers. The established LC/MS/MS method for plasma DIP determination had a linear range of 0.02-10 mg/mL, and the HPLC method for plasma PABA determination had a linear range of 0.05-40 mg/mL. Linear pharmacokinetic characteristics were found with single oral doses of 0.5, 1.0 and 2.0 g. No obvious accumulation effects were observed for DIP and PABA.

  6. Fluorescence detection of tramadol in healthy Chinese volunteers by high-performance liquid chromatography and bioequivalence assessment

    Directory of Open Access Journals (Sweden)

    Zhou X

    2015-02-01

    Full Text Available Xiao Zhou, Ji Liu Department of Anesthesia, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China Abstract: This study developed a revised high-performance liquid chromatography fluorescence method to determine plasma tramadol concentration, and thereby to examine the bioequivalence of two tramadol formulations among healthy male Chinese volunteers. The study used a double-blind, randomized, 2×2 crossover-design principle. Calculated pharmacokinetic parameters for both formulations were consistent with previous reports. According to the observation of vital signs and laboratory measurement, no subjects had any adverse reactions. The geometric mean ratios (90% confidence interval of the test drug/reference drug for tramadol were 100.2% (95.3%–103.4% for the area under the plasma concentration–time curve (AUC from time zero to the last measurable concentration, 99.6% (94.2%–102.7% for the AUC from administration to infinite time, and 100.8% (93.1%–106.4% for maximum concentration. For the 90% confidence intervals of the test/reference AUC ratio and maximum concentration ratio of tramadol, both were in the acceptance range for bioequivalence. According to the two preparations by pharmacokinetic parameter statistics, the half-life, mean residence time, and clearance values showed no significant statistical differences. Therefore, the conclusion of this study was that the two tramadol formulations (tablets and capsules were bioequivalent. Keywords: tramadol hydrochloride, in vitro release, pharmacokinetic, bioequivalence, fluorescence detector

  7. Comparative pharmacokinetic and pharmacodynamic evaluation of branded and generic formulations of meloxicam in healthy male volunteers

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    Del Tacca M

    2013-07-01

    Full Text Available Mario Del Tacca,1,2 Giuseppe Pasqualetti,3 Giovanni Gori,1 Pasquale Pepe,1 Antonello Di Paolo,2 Marianna Lastella,2 Ferdinando De Negri,1 Corrado Blandizzi2 1Clinical Pharmacology Centre for Drug Experimentation, Pisa University Hospital, 2Department of Clinical and Experimental Medicine, 3Geriatrics Unit, University of Pisa, Pisa, Italy Purpose: The primary aim of the present study was to assess the pharmacokinetic bioequivalence between a generic formulation of meloxicam 15 mg tablets (Meloxicam Hexal and its respective brand product (Mobic, in order to verify whether the generic product conforms to the regulatory standards of bioequivalence in the postmarketing setting. As a secondary exploratory aim, the pharmacodynamic effects of the two formulations were also evaluated by means of rating scales following hyperalgesia induced by cutaneous freeze injury. Subjects and methods: A single 15 mg dose of generic or branded meloxicam tablets was administered to 24 healthy male volunteers in a crossover fashion. Plasma samples, collected for 24 hours after dosing, were assayed for meloxicam concentration by a validated high-performance liquid chromatography method. Results: The analysis of pharmacokinetic parameters did not show any significant difference between the two meloxicam formulations: the 90% confidence intervals fell within the acceptance range of 80%–125% (0.84–1.16 for area under the curve [0–24], and 0.89–1.23 for peak concentration. No difference in the pharmacodynamic end point was observed between the two groups. Conclusion: The pharmacokinetic profiles of the two meloxicam formulations confirm the regulatory criteria for bioequivalence; pharmacodynamic data indicate a similar antihyperalgesic effect. The two formulations can be used interchangeably in the clinical setting. Keywords: meloxicam, pharmacokinetics, healthy volunteers, generic drug, bioequivalence, postmarketing

  8. Pharmacokinetics of Lidocaine Hydrochloride Metabolized by CYP3A4 in Chinese Han Volunteers Living at Low Altitude and in Native Han and Tibetan Chinese Volunteers Living at High Altitude.

    Science.gov (United States)

    Zhang, Juanling; Zhu, Junbo; Yao, Xingchen; Duan, Yabin; Zhou, Xuejiao; Yang, Meng; Li, Xiangyang

    2016-01-01

    To investigate the pharmacokinetics of lidocaine hydrochloride metabolized by cytochrome P450 3A4 (CYP3A4) in Chinese Han volunteers living at low altitude (LA) and in native Han and Tibetan Chinese volunteers living at high altitude, lidocaine hydrochloride 10 mg was given by intramuscular injection to 3 groups: Han volunteers living at LA, and native Han and Tibetan volunteers living at a high altitude. Blood samples were collected before the (baseline) study drug was given and at 0.25, 0.5, 1.0, 1.5, 2.0, 3.0, 4.0, 6.0, 8.0 h after study drug administration. Lidocaine hydrochloride in plasma was determined by RP-HPLC. Pharmacokinetics parameters of lidocaine hydrochloride showed that there were no significant difference between the native Han and Tibetan volunteers, but the t1/2 was 29.8 and 29.8% higher in 2 groups, respectively, than in the LA group. To study related mechanism, the effects of exposure to chronic high-altitude hypoxia (CHH) on the activity and expression of CYP3A1 were examined in rats. Rats were divided into LA, chronic moderate altitude hypoxia, and CHH groups. CHH caused significant decreases in the activity and protein and mRNA expression of rat CYP3A1 in vivo. This study found significant changes in the disposition of lidocaine hydrochloride in native healthy Tibetan and Han Chinese subjects living at a high altitude in comparison to healthy Han Chinese subjects living at LA, it might be due to significant decreases in the activity and protein and mRNA expression of CYP3A4 under CHH condition. PMID:26730802

  9. Safety and pharmacokinetics of dicloxacillin in healthy Chinese volunteers following single and multiple oral doses

    Directory of Open Access Journals (Sweden)

    Wu GL

    2015-10-01

    Full Text Available Guolan Wu, Yunliang Zheng, Huili Zhou, Xingjiang Hu, Jian Liu, You Zhai, Meixiang Zhu, Lihua Wu, Jianzhong Shentu Research Center for Clinical Pharmacy, State Key Laboratory for Diagnosis and Treatment of Infectious Disease, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China Background: Dicloxacillin, a semisynthetic isoxazolyl penicillin antibiotic, has antimicrobial activity against a wide variety of gram-positive bacteria including Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumonia, Streptococcus epidermidis, Streptococcus viridans, Streptococcus agalactiae, and Neisseria meningitidis. The objective of this study was to evaluate the safety and pharmacokinetic profile of dicloxacillin after single and multiple oral dose in healthy Chinese volunteers.Methods: A single-center, open-label, randomized, two-phase study was conducted in 16 subjects. In the single-dose phase, subjects were randomly assigned to receive single doses of 0.25, 0.5, 1.0, and 2.0 g of dicloxacillin sodium capsule in a 4-way crossover design with a 5-day washout period between administrations. In the multiple-dose phase, subjects were assigned to receive 0.25 or 0.5 g every 6 hours for 3 days in a 2-way crossover design. Plasma and urine pharmacokinetic samples were assayed by a validated high-performance liquid chromatography-tandem mass spectrometry method. Pharmacokinetic parameters were calculated and analyzed statistically. Safety assessments were conducted throughout the study.Results: Following a single oral dose of 0.25–2.0 g dicloxacillin sodium, the maximum plasma drug concentration (Cmax and the corresponding values for the area under the concentration–time curve from 0 to 10 hours (AUC0–10 h increased in a dose-proportional manner. The mean elimination half-life (t1/2 was in the range of 1.38–1.71 hours. Dicloxacillin was excreted in its unchanged form via the kidney, with no

  10. Effects of acute tryptophan depletion on executive function in healthy male volunteers

    Directory of Open Access Journals (Sweden)

    Young Allan H

    2003-08-01

    Full Text Available Abstract Background Neurocognitive impairment is frequently described in a number of psychiatric disorders and may be a direct consequence of serotonergic dysfunction. As impairments in executive functions are some of the most frequently described, the purpose of this study was to examine the performance of normal volunteers on a range of executive tasks following a transient reduction of central serotonin (5-HT levels using the method of acute tryptophan depletion (ATD. Methods Fifteen healthy male subjects participated in a within-subject, double-blind, counterbalanced crossover study. ATD was induced by ingestion of a 100 g amino-acid drink. Executive function was evaluated using the Wisconsin Card Sorting Test, Stroop, Verbal Fluency and Trail Making. Visual analogue scales were administered to assess mood. Results Plasma free and total tryptophan concentrations were significantly reduced by the depleting drink (P P = 0.027, with no effect on subjective ratings of mood. Interaction effects between drink and the order of drink administration were observed on most neurocognitive tests. Conclusions The improvement in simple motor speed/ attention following ATD is in keeping with the ascribed role of 5-HT in the cortex, however performance on tests of executive function is not robustly altered. The presence of interaction effects on most tasks suggests that subtle changes may occur but are masked, possibly by simple learning effects, in the context of a crossover design. This has implications for the design of future studies, particularly those examining executive functions.

  11. A pharmacoscintigraphic study of three time-delayed capsule formulations in healthy male volunteers.

    Science.gov (United States)

    McConville, Jason T; Hodges, Lee-Ann; Jones, Tamara; Band, Janet P; O'Mahony, Bridget; Lindsay, Blythe; Ross, Alistair C; Florence, Alastair J; Stanley, Adrian J; Humphrey, Michael J; Wilson, Clive G; Stevens, Howard N E

    2009-11-01

    Three time-delayed capsule (TDC) formulations were investigated in a pharmacoscintigraphic study, using a three-way crossover design in eight healthy male volunteers. Additionally, the pulsed release of a TDC was investigated with time-lapse photography, using a nondisintegrating riboflavin tablet. The photographic study indicated how the release characteristics of the TDC relied on the erosion of a tablet containing hypromellose (HPMC). Each TDC was duel radio labelled with indium-111 and technetium-99 m DTPA complexes, to observe drug release scintigraphically (theophylline was a marker compound). Three formulations, having in vitro dissolution release times of 1.8, 2.9 or 4.0 h were shown to compare favourably with mean in vivo scintigraphic release times of 2.7, 3.0 and 4.0 h for each formulation containing 20, 24 or 35% (w/w) HPMC concentrations respectively. An increase in HPMC concentration was associated with a delayed technetium release time, and followed the same rank order as the in vitro dissolution study. Observed radiolabel dispersion always occurred in the small intestine. In conclusion, the study established that the TDC performs and demonstrates an in vitro-in vivo correlation. Additionally, time and site of release were accurately visualized by gamma scintigraphy, and confirmed with determination of theophylline absorption. PMID:19387976

  12. The disposition of bupropion and its metabolites in healthy male volunteers after single and multiple doses.

    Science.gov (United States)

    Posner, J; Bye, A; Dean, K; Peck, A W; Whiteman, P D

    1985-01-01

    The pharmacokinetics of bupropion and 3 of its basic metabolites were determined in 8 young, healthy, male volunteers after single and multiple oral doses of bupropion. Plasma profiles were obtained: 1) after a single 100 mg oral dose of bupropion hydrochloride, 2) following administration of 100 mg 8-hourly for 14 days and 3) again after a single 100 mg dose 14 days later. Plasma concentrations of the parent drug and metabolites were determined by high-performance liquid chromatography. Saliva secretion and pupil diameters were measured, subjective assessments of sleep made using visual analogue scales and side effects, blood counts and biochemistry were monitored. After the first dose mean elimination half lives (t1/2) of bupropion, and metabolites I and II were 8, 19 and 19 h respectively. On repeated administration there was little accumulation of the parent drug and no evidence for induction of its own metabolism. Accumulation of I was consistent with its rate of elimination after single doses while that of II was greater than predicted with prolongation of t1/2 to 35 h. Metabolite III was barely detectable after single doses but its accumulation on multiple dosing was consistent with its long half life (35 h) determined on occasion 2. Saliva secretion was significantly reduced during the multiple dosing period but there were no complaints of dry mouth. Subjective assessments of sleep were not significantly altered though one subject reported vivid dreams. There were no other adverse reactions. PMID:3932079

  13. Stereoselectivity in metabolic 3-reduction of tibolone in healthy Chinese female volunteers

    Institute of Scientific and Technical Information of China (English)

    Ming ZUO; Ming-jie GAO; Zhen LIU; Lei CAI; Geng-li DUAN

    2005-01-01

    Aim: To investigate the stereoselectivity in human metabolic 3-reduction oftibolone. Methods: Twenty healthy Chinese female volunteers were given a singleoral dose of tibolone (2.5 mg), and serial blood samples were collected aftertreatment. The plasma concentrations of the two pharmacologically active 3-hydroxyl metabolites of tibolone, 3α-hydroxyl-7-methyl- norethynodrel (3α-HMN)and 3β-hydroxyl-7-methyl- norethynodrel (3β-HMN) in plasma were determinedby using a validated liquid chromatography-mass spectrometry (LC-MS) method.Results: The apparent elimination half-life (T1/2) of 3α-HMN was 1.43±0.52 h, andthat of 3β-HMN was 1.53±0.60 h. Maximum plasma concentrations (Cmax) werefound to be 8.75±4.36 μg/L for 3α-HMN and 3.59±1.81 μg/L for 3β-HMN. Areash-1. L-1 for 3α-HMN and 9.89±4.93 μg.h-1. L-1 for 3β-HMN. Conclusion: Stereoselective differences exist in the pharmacokinetics of tibolone metabolism in humans.

  14. Metabolic fate of radiolabeled prostaglandin D2 in a normal human male volunteer

    International Nuclear Information System (INIS)

    50 microCi of [3H]prostaglandin D2 tracer (100 Ci/mmol) was infused intravenously into a normal human male volunteer. 75% of the infused radioactivity was excreted into the urine within 5 h. This urine was added to urine obtained from two mastocytosis patients with marked overproduction of prostaglandin D2. Radiolabeled prostaglandin D2 urinary metabolites were chromatographically isolated and purified and subsequently identified by gas chromatography-mass spectrometry. 25 metabolites were identified. 23 of these compounds comprising 37% of the recovered radioactivity had prostaglandin F-ring structures, and only two metabolites comprising 2.7% of the recovered radioactivity retained the prostaglandin D-ring structure. The single most abundant metabolite identified was 9,11-dihydroxy-15-oxo-2,3,18,19-tetranorprost-5-ene-1,20-dioic acid which was isolated in a tricyclic form as a result of formation of a lower side chain hemiketal followed by lactonization of the terminal carboxyl and the hemiketal hydroxyl. Different isomeric forms of several prostaglandin F-ring metabolites were identified. An isomer of prostaglandin F2 alpha was also excreted intact into the urine as a metabolite of prostaglandin D2. 15 PGF-ring compounds were treated with n-butylboronic acid and 13 failed to form a boronate derivative, suggesting that the orientation of the hydroxyl group at C-11 in these 13 metabolites is beta. This study documents that prostaglandin D2 is metabolized to prostaglandin F-ring metabolites in vivo in humans. These results also bring into question the accuracy of quantifying prostaglandin F2 alpha metabolites as a specific index of endogenous prostaglandin F2 alpha biosynthesis, as well as quantifying urinary prostaglandin F2 alpha as an accurate index of renal production of prostaglandin F2 alpha

  15. Metabolic fate of radiolabeled prostaglandin D2 in a normal human male volunteer

    Energy Technology Data Exchange (ETDEWEB)

    Liston, T.E.; Roberts, L.J. 2d.

    1985-10-25

    50 microCi of (TH)prostaglandin D2 tracer (100 Ci/mmol) was infused intravenously into a normal human male volunteer. 75% of the infused radioactivity was excreted into the urine within 5 h. This urine was added to urine obtained from two mastocytosis patients with marked overproduction of prostaglandin D2. Radiolabeled prostaglandin D2 urinary metabolites were chromatographically isolated and purified and subsequently identified by gas chromatography-mass spectrometry. 25 metabolites were identified. 23 of these compounds comprising 37% of the recovered radioactivity had prostaglandin F-ring structures, and only two metabolites comprising 2.7% of the recovered radioactivity retained the prostaglandin D-ring structure. The single most abundant metabolite identified was 9,11-dihydroxy-15-oxo-2,3,18,19-tetranorprost-5-ene-1,20-dioic acid which was isolated in a tricyclic form as a result of formation of a lower side chain hemiketal followed by lactonization of the terminal carboxyl and the hemiketal hydroxyl. Different isomeric forms of several prostaglandin F-ring metabolites were identified. An isomer of prostaglandin F2 alpha was also excreted intact into the urine as a metabolite of prostaglandin D2. 15 PGF-ring compounds were treated with n-butylboronic acid and 13 failed to form a boronate derivative, suggesting that the orientation of the hydroxyl group at C-11 in these 13 metabolites is beta. This study documents that prostaglandin D2 is metabolized to prostaglandin F-ring metabolites in vivo in humans. These results also bring into question the accuracy of quantifying prostaglandin F2 alpha metabolites as a specific index of endogenous prostaglandin F2 alpha biosynthesis, as well as quantifying urinary prostaglandin F2 alpha as an accurate index of renal production of prostaglandin F2 alpha.

  16. Comparative bioavailability study of two cefixime formulations administered orally in healthy male volunteers.

    Science.gov (United States)

    Zakeri-Milani, Parvin; Valizadeh, Hadi; Islambulchilar, Ziba

    2008-01-01

    The bioavailability of a new cefixime ((6R,7R)-7-[(Z)-2-(2-amino-4-thiazolyl)-2-(carboxymethoxyimino) acetamido]-8-oxo-3-vinyl-5-thia-1-azabicyclo-[4,2,0]-oct-2-ene-2-carboxylic acid, CAS 79350-37-1) tablet preparation (Loprax) was compared with that of a reference preparation of the drug in 24 healthy male volunteers. The trial was designed as an open, randomized, single-blind, two-sequence, two-period crossover study. Under fasting conditions, each subject received a single oral dose of 400 mg cefixime tablet as a test or reference formulation on 2 treatment days. The treatment periods were separated by a one-week washout period. The plasma concentrations of the drug were analyzed by a rapid and sensitive HPLC method with UV detection. The pharmacokinetic parameters included AUC0-24h, AUC0-infinity, Cmax, t1/2, and Ke. The mean AUC0-infinity of cefixime was 45008.7 +/- 10989.9 and 45221.3 +/- 2155.7 n x h/ml for the test and reference formulation, respectively. The maximum plasma concentration (Cmax) of cefixime was on average 4746.9 +/- 1284 ng/ml for the test and 4726.3 +/- 1206.9 ng/ml for the reference product. No statistical differences were observed for Cmax and the area under the plasma concentration-time curve for test and reference tablets. The calculated 90% confidence intervals based on the ANOVA analysis for the mean test/reference ratios of Cmax, AUC0-infinity and AUC0-24h of cefixime were in the bioequivalence range (94%-112%). Therefore, the two formulations were considered to be bioequivalent. PMID:18412024

  17. 美洛昔康在中国健康受试者体内的药物动力学研究%PHARMACOKINETICS OF MELOXICAM IN HEALTHY CHINESE VOLUNTEERS

    Institute of Scientific and Technical Information of China (English)

    徐海燕; 钟大放; 肇丽梅; 张逸凡; 张宝军

    2001-01-01

    AIM To assess the pharmacokinetic profile of single doses of meloxicam in healthy Chinese volunteers. METHODS The plasma concentrations of meloxicam after an oral dose of 15 mg to twenty healthy male volunteers were analized by means of a validated HPLC method. The pharmacokinetic parameters were subjected to Shapiro-Wilk test to determine whether these data were fitted to a normal distribution. RESULTS The twenty volunteers can be classified into extensive metabolizers and poor metabolizers according to pharmacokinetic parameters. The main parameters in the two groups obtained were as follows: T1/2 were 21±4 and 38±9 h, AUC0-∞ were 49±10 and 110±8 μg*h*mL-1, respectively. Even the AUC data in extensive metabolizers were 1.7 times as that reported in White volunteers following the same doses of meloxicam. CONCLUSION There were significant individual differences in the pharmacokinetics of meloxicam in Chinese volunteers, which may be due to the genetic polymorphism of CYP2C9.

  18. Results of feeding trials of irradiated diets in human volunteers: Summary of the Chinese studies

    International Nuclear Information System (INIS)

    Following extensive chemical analyses and animal experimentation, which have shown that irradiated foods are safe, the Chinese researchers have carried out 8 well controlled experiments involving human volunteers consuming irradiated foods for 7 to 15 weeks periods. There were 17 to 70 test subjects in each experiment, and the total number of subjects was 439. Each clinical test in all the experiments failed to discern any significant difference between the control groups and the test groups consuming irradiated foods. Seven of the eight experiments involved investigations of chromosomal aberrations in a total of 382 individuals. Some of these experiments included freshly irradiated wheat in the diet. No significant difference between the number of chromosomal aberrations in the control groups and the test groups could be discerned in any of the seven experiments, either when evaluated individually or when all seven were pooled together. When all the experiments were pooled together, the average number of polyploidy at the beginning of the tests, before the exposure to irradiated foods, was 0.22% and 0.36% for the control and experimental groups respectively and after the exposure to the irradiated foods the polyploidy was 0.29% and 0.26% in the control and in the experimental groups respectively. The standard deviation of the mean value, 0.28%, was 0.23%. The relative increase in polyploidy in the control group, 0.29%-0.22%=+0.07%, and the relative decrease in the polyploidy in the experimental group, 0.26%-0.36%=-0.10% is statistically insignificant. In separate experiments it was shown that irradiation significantly reduces carcinogenic nitrosamines found in many foods confirming similar observation at U.S. Army Natick Laboratories in the 70's. (author). 51 refs, 2 tabs

  19. Bioequivalence study of a generic Risperidone (Iperdal® in healthy Thai male volunteers

    Directory of Open Access Journals (Sweden)

    Werawath Mahatthanatrakul

    2008-05-01

    Full Text Available The objective of this study was to compare the rate and extent of absorption of a generic risperidone (Iperdal® with a reference formulation (Risperdal® when given orally. The study was an open label, randomized, two-period, two-sequence,single dose cross-over design with a 2 weeks washout period in 16 healthy Thai male volunteers. Single oral dose of two 2-mg tablets of risperidone were administered and serial blood samples were collected from the antecubital vein before and at0.17, 0.33, 0.5, 0.75, 1.0, 1.5, 2.0, 3.0, 4.0, 6.0, 8.0, 12, 24 and 48 hours post dose. Risperidone plasma concentrations were assayed using a validated High Performance Liquid Chromatographic (HPLC-UV method modified from Avenosoet al. (2000. Pharamcokinetic parameters i.e. Cmax, AUC0à48 and Tmax were analyzed by noncompartment analysis. Variations of the data were analyzed by “Two Way Analysis of Variance” (ANOVA. Statistics were tested as stated in USP 28 guidelinefor bioequivalence study. The maximum concentration (Cmax, ng/ml of risperidone for the innovator and the generic product were 31.11±17.24 (range 5.64-56.78 and 32.58±19.77 (range 5.29-84.56 ng/ml, respectively. The area under theplasma concentration-time curve (AUC0®48 of the innovator and the generic product were 160.64±152.89 (range 18.57- 550.32 and 144.03±127.37 (range 16.27-456.0 ng.hr/ml, respectively. The time to maximum concentration (Tmax of theinnovator and the generic product were 0.97±0.41(range 0.5-2 and 1.02±0.32 (range 0.5-1.5 hr, respectively. The 90% confidence interval of the ratio of the ln-transformed of Cmax and AUC0à48 of both preparations were 89.39-112.99% and80.02-107.28% respectively which were within the acceptance range of 80.00-125.00%. Therefore, it can be concluded that both preparations used in this study are bioequivalent in terms of both the rate and extent of absorption.

  20. Upper Gastrointestinal Symptoms Are More Frequent in Female than Male Young Healthy Japanese Volunteers as Evaluated by Questionnaire

    Science.gov (United States)

    Kawakubo, Hiroharu; Tanaka, Yuichiro; Tsuruoka, Nanae; Hara, Megumi; Yamamoto, Koji; Hidaka, Hidenori; Sakata, Yasuhisa; Shimoda, Ryo; Iwakiri, Ryuichi; Kusano, Motoyasu; Fujimoto, Kazuma

    2016-01-01

    Background/Aims Upper gastrointestinal symptoms are more frequent and severe in female than in male outpatients in Japan. This study compared the upper gastrointestinal symptoms between healthy male and female young adult volunteers using a questionnaire. Methods In total, 581 third-grade medical students at Saga Medical School aged 22 to 30 years underwent upper gastrointestinal endoscopy and completed a questionnaire (frequency scale for symptoms of gastroesophageal reflux disease) from 2007 to 2013. Of these 581 students, 298 who were negative for Helicobacter pylori infection and had no particular lesions on endoscopic examination were enrolled in the present evaluation. A symptom was defined as positive when the subject evaluated the frequency of the symptom as sometimes, often, or always. Results The subjects comprised of 163 males (average age, 23.7 years) and 135 females (average age, 23.1 years). Upper gastrointestinal symptoms were more frequent in the females (75 of 135, 55.6%) than males (69 of 163, 42.3%; P eating meals). Of the 144 subjects (69 males and 75 females) who complained of these symptoms, the females complained of dysmotility symptoms more often than did the males, but this was not true for reflux symptoms. Conclusions This study suggests that females develop upper gastrointestinal symptoms more frequently than do males among the young healthy Japanese population. PMID:26755685

  1. Beta-endorphin (1-31) in the plasma of male volunteers undergoing physical exercise.

    Science.gov (United States)

    Harbach, H; Hell, K; Gramsch, C; Katz, N; Hempelmann, G; Teschemacher, H

    2000-08-01

    beta-Endorphin is an opioid peptide representing the C-terminal 31 amino acid residue fragment of proopiomelanocortin (POMC). The release of beta-endorphin from the pituitary into the cardiovascular compartment under physical or emotional stress has been frequently reported. However, besides beta-endorphin (1-31), nine acetylated or non-acetylated beta-endorphin analogues exist - in addition to N-terminally elongated beta-endorphin derivatives such as beta-lipotropin (beta-LPH). Since conventional radioimmunoassays (RIAs) and even commercially available two site-RIAs pick up at least some of those beta-endorphin derivatives, only "beta-endorphin immunoreactive materials" and not authentic beta-endorphin have been determined in those studies. We have developed a highly specific two site-RIA for beta-endorphin (1-31), which does not cross-react with all beta-endorphin derivatives known to occur as yet. Using this RIA as well as further assays for determination of beta-endorphin (1-31), beta-endorphin immunoreactive material (IRM), ACTH and Cortisol in the plasma of 14 volunteers upon intensive physical exercise, we found authentic beta-endorphin only in about 50% of the plasma samples, representing therein only a minor portion of the beta-endorphin IRM. PMID:10840168

  2. A rapid and sensitive LC-MS/MS method for determination of lercanidipine in human plasma and its application in a bioequivalence study in Chinese healthy volunteers.

    Science.gov (United States)

    Li, Xiaobing; Shi, Fuguo; He, Xiaojing; Jian, Lingyan; Ding, Li

    2016-09-01

    A rapid and highly sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed and validated for the determination of lercanidipine (LER) in human plasma. The plasma sample was deproteinized with methanol after addition of diazepam (internal standard, IS) and separated on a 38°C Hedera ODS-2 analytical column with a mobile phase of methanol and 5mM ammonium acetate buffer solution containing 0.1% formic acid at an isocratic flow rate of 400μL/min. The detection was performed on an API 4000 tandem mass spectrometer coupled with electrospray ionization (ESI) source in positive ESI mode. Quantification was conducted by multiple reaction monitoring (MRM) of the transitions of m/z 612.2→280.2 for LER and m/z 285.1→193.1 for IS, respectively. The method exhibited high sensitivity (LLOQ of 0.015ng/mL) and good linearity over the concentration range of 0.015-8.0ng/mL. No matrix effect and carry-over effect were observed. The values on both the occasions (intra- and inter-day) were all within 15% at three concentration levels. This robust method was successfully applied in a bioequivalence study to evaluate the pharmacokinetics of LER in 59 healthy male Chinese volunteers after a single oral administration of 10mg LER. PMID:27232153

  3. Rapid and Sensitive LC-MS/MS Method for Quantification of Fexofenadine in Human Plasma——Application to a Bioequivalence Study in Chinese Volunteers

    Institute of Scientific and Technical Information of China (English)

    TENG Guo-sheng; TENG Le-sheng; WU Yi; TANG Yun-biao; LIU Lan-ying; GU Jing-kai

    2007-01-01

    A rapid and sensitive liquid chromatography-tandem mass spectrometry method(LC-MS/MS) was developed and validated for the quantification of fexofenadine in human plasma, to conduct comparative bioavailability studies. Human plasma was extracted with a mixture of dichloromethane-diethyl ether( volume ratio 2:3) in a basic environment and the extract was separated on a C18 column with a mobile phase consisting of acetonitrile-methanol-10 mmol/L amspectrometry in the multiple-reaction-monitoring(MRM) mode. The linearity was within a range of 1-1000 ng/mL.The intra- and inter-day precision were <4.1% and <4.8%, respectively, and the accuracy was in the range of 95.0%-105%. The method was applied to the quantification of fexofenadine human plasma from 20 healthy male Chinese volunteers, according to a single dose, randomized, two-way crossover design with a two-week washout period. The mean values of major pharmacokinetic parameters of ρmax, AUC0-48, AUC0-∞, tmax, and t1/2 were determined from the plasma concentration. The analysis of variance(ANOVA) did not show any significant difference between the two products of fexofenadine and 90% confidence intervals fell within the acceptable range for bioequivalence.

  4. Determination of risperidone in human plasma by HPLC-MS/MS and its application to a pharmacokinetic study in Chinese volunteers

    Institute of Scientific and Technical Information of China (English)

    Ming-zhu HUANG; Jian-zhong SHENTU; Junc-hun CHEN; Jian LIU; Hui-li ZHOU

    2008-01-01

    This study presents a rapid, specific and sensitive liquid chromatography/tandem mass spectrometry (LC-MS/MS) assay for determination of risperidone (RIS) in human serum using paroxetine as an internal standard (IS). An Alltima-C 18separation. The analysis was performed by selected reaction monitoring (SRM) method, and the peak area of the m/z 411.3→ 191.1 transition for RIS was measured versus that of the m/z 330.1→192.1 transition for IS to generate the standard curves. The assay linearity of RIS was confirmed over the range 0.25~50.00 ng/ml and the limit of quantitation was 0.05 ng/ml. The linear range corresponds well with the serum concentrations of the analytes obtained in clinical pharmacokinetic studies. Intraday and interday relative standard deviations were 1.85%~9.09% and 1.56%~4.38%, respectively. The recovery of RIS from serum was in the range of 70.20%~84.50%. The method was successfully applied to investigate the bioequivalence between two kinds of tablets (test versus reference products) in 18 healthy male Chinese volunteers. The result suggests that two formulations are bioequivalent.

  5. Variability in the pharmacokinetics and pharmacodynamics of low dose aspirin in healthy male volunteers.

    Science.gov (United States)

    Benedek, I H; Joshi, A S; Pieniaszek, H J; King, S Y; Kornhauser, D M

    1995-12-01

    Data describing the pharmacokinetics and pharmacodynamics of low dose aspirin (acetylsalicylic acid; ASA) are limited. This single-center study was designed to determine the rate and extent of oral absorption of 80-mg ASA tablets in healthy, young male subjects and to assess the intra- and inter-subject variability of ASA pharmacokinetics and platelet aggregation effects. Ten subjects each received a single, open-label, oral 80-mg ASA dose on three separate days. Each dose was separated by a 2-week washout interval. Blood samples for pharmacokinetic determinations of ASA and its metabolite, salicylic acid (SA) and platelet aggregation studies were obtained at scheduled timepoints before and up to 24 hours after each dose. Peak plasma ASA levels of 1 microgram/mL were achieved within 30 minutes. Peak plasma SA levels of approximately 4 micrograms/mL were attained in 1 hour. The terminal half-lives (t1/2) of ASA and SA were 0.4 and 2.1 hours, respectively. Both ASA and SA pharmacokinetics and the platelet aggregation response to ASA exhibited considerable intra- and inter-subject variability. Inhibition of platelet aggregation was found to relate with ASA area under the plasma concentration versus time curve (AUC). PMID:8750369

  6. The effect of Ginkgo biloba on memory in healthy male volunteers.

    Science.gov (United States)

    Moulton, P L; Boyko, L N; Fitzpatrick, J L; Petros, T V

    2001-07-01

    The purpose of this study was to investigate possible effects of Ginkgo biloba, a widely used herbal extract, on memory. This study incorporated a double-blind, placebo-controlled design, which used 30 healthy male subjects in each of two groups. The treatment group received two 60-mg tablets of BioGinkgo (27/7) [corrected] daily for 5 days, while the placebo group received a placebo. On the fifth day, after a 2-h waiting period, all subjects were given the Sternberg Memory Scanning Test [Q. J. Exp. Psychol. 27 (1975) 1.], a reaction time control test, the vocabulary and digit span subtests of the WAIS-R [Wechsler D. Manual for the Wechsler adult intelligence scale - revised. New York: Psychological Corporation, 1981.], a reading span test [J. Verbal Learn. Verbal Behav. 19 (1980) 450.] and a prose recall test [Discourse Proc. 13 (1990) 387.]. Blood pressure, heart rate and side effects were also monitored throughout the study. Nonsignificant results were found on all interactions involving treatment group on all tests except the Sternberg Memory Scanning Test. The extract appeared to be safe but largely ineffective in enhancing memory. PMID:11495672

  7. Effects of a milk product, fermented by Lactobacillus acidophilus and with fructo-oligosaccharides added, on blood lipids in male volunteers

    NARCIS (Netherlands)

    Schaafsma, G.; Meuling, W.J.A.; Dokkum, W. van; Bouley, C.

    1998-01-01

    Objective: To investigate in adult male volunteers the effect of a new fermented milk product, fermented by Lactobacillus acidophilus and with fructo-oligosaccharides added, on blood lipids. Design: Randomized placebo-controlled double-blind two-way cross over trial with two treatment periods of thr

  8. The Effect of Chronic Alprazolam Intake on Memory, Attention, and Psychomotor Performance in Healthy Human Male Volunteers

    Directory of Open Access Journals (Sweden)

    Zahid Sadek Chowdhury

    2016-01-01

    Full Text Available Alprazolam is used as an anxiolytic drug for generalized anxiety disorder and it has been reported to produce sedation and anterograde amnesia. In the current study, we randomly divided 26 healthy male volunteers into two groups: one group taking alprazolam 0.5 mg and the other taking placebo daily for two weeks. We utilized the Cambridge Neuropsychological Test Automated Battery (CANTAB software to assess the chronic effect of alprazolam. We selected Paired Associates Learning (PAL and Delayed Matching to Sample (DMS tests for memory, Rapid Visual Information Processing (RVP for attention, and Choice Reaction Time (CRT for psychomotor performance twice: before starting the treatment and after the completion of the treatment. We found statistically significant impairment of visual memory in one parameter of PAL and three parameters of DMS in alprazolam group. The PAL mean trial to success and total correct matching in 0-second delay, 4-second delay, and all delay situation of DMS were impaired in alprazolam group. RVP total hits after two weeks of alprazolam treatment were improved in alprazolam group. But such differences were not observed in placebo group. In our study, we found that chronic administration of alprazolam affects memory but attentive and psychomotor performance remained unaffected.

  9. The bioavailability of Tamoplex (tamoxifen). Part 2. A single dose cross-over study in healthy male volunteers.

    Science.gov (United States)

    Guelen, P J; Stevenson, D; Briggs, R J; de Vos, D

    1987-10-01

    Tamoxifen and N-desmethyltamoxifen plasma concentrations were determined in a single dose cross-over study with Tamoplex and Nolvadex at the dose height of 40 mg in 18 healthy male volunteers with a wash-out period of at least 140 days. ANOVA, power analysis and novel bioequivalence tests on AUC, Cmax and tcmax, including a non-parametric one, demonstrated bioequivalence of Tamoplex and Nolvadex 10 mg tablets. The mean AUC ( +/- SD) values of tamoxifen after administration of Tamoplex or Nolvadex tablets were 1076 +/- 265 and 1131 +/- 301 h ng ml-1, respectively. ANOVA on the AUC values gave a p value of 0.450 with a power of 0.85 and a 95% confidence interval of 81.8-108.5% was obtained. The 0.8 power test showed a determined difference of 18.9%, whereas the actual difference was 4.9%. Interindividual and intraindividual variation was assessed. The pharmacokinetic data, well established for 34 hr, constitute a basis for further studies on tamoxifen distribution, elimination and metabolism. PMID:3441162

  10. A low TSH profile predicts olanzapine-induced weight gain and relief by adjunctive topiramate in healthy male volunteers.

    Science.gov (United States)

    Evers, Simon S; van Vliet, André; van Vugt, Barbara; Scheurink, Anton J W; van Dijk, Gertjan

    2016-04-01

    Second generation antipsychotics, like olanzapine (OLZ), have become the first line drug treatment for patients with schizophrenia. However, OLZ treatment is often associated with body weight (BW) gain and metabolic derangements. Therefore, the search for prospective markers for OLZ's negative side effects as well as adjunctive treatments to inhibit these has been of major interest. The aim of this study was to investigate in healthy male volunteers (age: 36 ± 11 years; BW: 84 ± 12 kg; BMI=25.5 ± 2.5) whether adjunctive topiramate (TPM) administration opposes OLZ-induced weight gain over the course of 14 days treatment. In addition, we investigated behavioral, endocrine and metabolic characteristics as underlying and potentially predictive factors for weight regulation and/or metabolic derangements associated with OLZ and TPM treatment. While adjunctive TPM indeed reduced OLZ-induced weight gain (Phormones revealed that individuals with a low plasma TSH profile were also those that were most sensitive to adjunctive TPM treatment blocking OLZ-induced ΔBW gain. Others have shown that OLZ-induced BW gain is associated with improvement in brief psychiatric rating scores (BPRS); adjunctive TPM treatment may be a solution specifically for those subjects susceptible to OLZ-induced rapid weight gain who-on a therapeutic level-benefit most of OLZ treatment. PMID:26802597

  11. Determination of ifenprodil by LC–MS/MS and its application to a pharmacokinetic study in healthy Chinese volunteers

    Directory of Open Access Journals (Sweden)

    Jing Yang

    2013-05-01

    Full Text Available This paper reports the development and validation of an assay for ifenprodil based on liquid chromatography–tandem mass spectrometry (LC–MS/MS and its application to a pharmacokinetic study involving single and multiple intravenous infusions to healthy Chinese volunteers. After sample preparation of plasma by liquid–liquid extraction with ethyl acetate, the analyte and internal standard, urapidil, were separated by reversed phase chromatography in a run time of 4 min and detected by positive ion electrospray ionization followed by multiple reaction monitoring of the precursor-to-product ion transitions at m/z 326.2→308.1 for ifenprodil and m/z 388.4→205.3 for IS. The assay was linear in the concentration range 0.2–50.0 ng/mL with recovery >76.4%. In the pharmacokinetic study of single intravenous infusions of 5, 10 and 15 mg ifenprodil, peak plasma concentrations and areas under the plasma concentration–time curve were both linearly related to dose. In the pharmacokinetic study of multiple once daily intravenous infusions of 10 mg ifenprodil for 7 days, pharmacokinetic parameters were similar to those after the single dose showing that ifenprodil does not accumulate on repeated administration.

  12. Liquid Chromatography-Electrospray Quadrupole Linear Ion Trap Mass Spectrometric Method for Quantitation of Domperidone in Chinese Healthy Volunteers

    Institute of Scientific and Technical Information of China (English)

    WU Yi; CHU Yang; ZHANG Yun-hui; WU Dan; GU Jing-kai

    2007-01-01

    A rapid, sensitive, and accurate method based on LC/MS/MS was developed and validated for the determination of domperidone in human plasma. Domperidone and internal standard, tramadol, were extracted from plasma with diethyl ether-dichloromethane(60: 40, volume ratio) and separated by reversed-phase HPLC with methanol-water-ammonia solution(80: 20: 0.2, volume ratio) as the mobile phase. Detection was carried out via multiple-reaction monitoring(MRM) on a Q-trapTM LC/MS/MS system(Q-trapTM). The assay result was linear over a concentration range of 0.1-30 ng/mL with a limit of quantitation (LOQ) of 0.1 ng/mL. The inter- and intra-day precision levels were within 7.52% and 12. 9%, respectively, whereas the accuracy was within a range of 87. 3%-114%. This method has been successfully applied to evaluate the pharmacokinetics of domperidone in Chinese healthy volunteers given an oral dose of 10 mg.

  13. Pharmacokinetics of levosulpiride after single and multiple intramuscular administrations in healthy Chinese volunteers

    Directory of Open Access Journals (Sweden)

    Chuting Gong

    2014-10-01

    Full Text Available The main purpose of this study was to evaluate the pharmacokinetics of levosulpiride in humans after single and multiple intramuscular injections. Six males and six females received single dose of either 25 mg or 50 mg levosulpiride, or multiple doses of 25 mg every 12 h for 5 consecutive days. In the single 25 mg study, the mean peak plasma concentration (Cmax was 441 ng/mL, the mean area under the concentration–time curve from 0 to 36 h (AUC0–36 was 1724 ng h/mL, and the mean elimination half-life (t1/2 was 7.0 h. In the single 50 mg study, the mean Cmax was 823 ng/mL, the mean AUC0–36 was 3748 ng·h/mL, and the mean t1/2 was 6.8 h. After multiple doses of 25 mg levosulpiride, the average plasma concentration (Cav was 136 ng/mL, the fluctuation index (DF was 3.60, and the accumulation ratio (R was 1.2. Levosulpiride injections appeared to be well tolerated by the subjects, and can be used for successive administration.

  14. Pharmacokinetic profile of cefbuperazone in healthy Chinese volunteers after single and multiple drip intravenous infusion by HPLC-MS/MS.

    Science.gov (United States)

    Liu, Dongbo; Geng, Taohua; Wang, Yiya; Ding, Li

    2016-09-10

    A selective and reproducible HPLC-MS/MS method was developed and fully validated for the determination of cefbuperazone in human plasma and urine. Samples were prepared using protein precipitation and separated on a Zorbax Eclipse Plus C18 column (2.1×50mm, 3.5μm). The API-4000 mass spectrometer was operated under multiple reaction monitoring mode (MRM) using the electrospray ionization technique. Linearity was achieved from 0.250 to 250μg/mL in plasma and 20.0-5000μg/mL in urine. The method was successfully applied to a pharmacokinetic study of cefbuperazone in healthy Chinese volunteers after drip intravenous infusion of 0.5, 1.0, 2.0g cefbuperazone sodium injection. Cefbuperazone reached a maximum concentration (Cmax) of 44.7±8.1μg/mL, 86.7±12.7μg/mL and 168±14μg/mL in 0.5, 1.0 and 2.0g dose groups respectively, at 60min after the start of infusion. The half-life (t1/2) was between 1.8-1.9h, and the elimination constant (kel) was between 0.36-0.39h(-1). The results proved that cefbuperazone showed linear pharmacokinetic profile in the dose range of 0.5-2.0g without gender difference. Drug accumulation was not observed. Cefbuperazone reached the maximum excretion rate in urine 2h after the start of infusion. About 60.0% of the administered drug was excreted via urine as unchanged form within 12h. The cumulative excretion of cefbuperazone after single drip intravenous infusion was proportional to the administered dose within the range from 0.5g to 2.0g. PMID:27394175

  15. Reproducibility of and correspondence among different hepcidin forms in blood and urine and their relationships to iron status in healthy, male Guatemalan volunteers observed over 9 weeks

    OpenAIRE

    Schuemann, K.; Solomons, N.W.; Laarakkers, C.M.; Romero-Abal, M.E.; Kroll, S.; Weiss, G.; Swinkels, D. W.

    2011-01-01

    BACKGROUND/AIMS: Prohepcidin and the active form hepcidin-25 are two variants of the peptide hormone hepcidin for iron homoeostasis. Their regulatory role and usefulness as biomarkers of the iron status are uncertain. Our aim is to describe the intra-individual variance of serum and urinary hepcidin-25 and prohepcidin concentrations, the mutual associations of the 4 hepcidin formats, and their correspondence with iron status variables in male Guatemalan volunteers. METHODS: Eight healthy adul...

  16. Ethnic differences in body composition and obesity related risk factors: study in Chinese and white males living in China.

    Directory of Open Access Journals (Sweden)

    Dong Wang

    Full Text Available The purpose of this cross-sectional observational study was to identify ethnic differences in body composition and obesity-related risk factors between Chinese and white males living in China. 115 Chinese and 114 white male pilots aged 28-63 years were recruited. Fasting body weight, height and blood pressure were measured following standard procedures. Whole-body and segmental body composition were measured using an 8-contact electrode bioimpedance analysis (BIA system. Fasting serum glucose, fasting plasma total cholesterol (TC, high-density lipoprotein (HDL cholesterol, and triglycerides (TG were assessed using automatic biochemistry analyzer. After adjusting for age and body mass index (BMI, Chinese males had significantly higher percentage of body fat (PBF both with respect to whole body (Chinese: 23.7%±0.2% vs. Whites: 22.4%±0.2% and the trunk area (Chinese: 25.0%±0.3% vs. Whites: 23.2%±0.3% compared to their white counterparts. At all BMIs, Chinese males had significantly higher fasting glucose levels (Chinese: 5.7±1.0 mmol/L vs. Whites: 5.2±1.0 mmol/L but lower high-density lipoprotein levels (Chinese: 0.8±1.0 mmol/L vs. Whites: 1.0±1.0 mmol/L than white males. In addition, a marginally significantly higher diastolic blood pressure was found among Chinese men than that among white men (Chinese: 80±1.0 mmHg vs. Whites: 77±1.0 mmHg. Chinese males had more body fat and a greater degree of central fat deposition pattern than that seen in white males in the present study. Furthermore, data on blood pressure, fasting glucose and blood lipids suggest that Chinese men may be more prone to obesity-related risk factors than white men.

  17. 非布司他在健康受试者体内的尿药排泄特征%Study on Urinary Excretion Characteristics of Febuxostat in Healthy Chinese Volunteers

    Institute of Scientific and Technical Information of China (English)

    周颖; 丁黎; 刘筱雪; 黄瑶; 马鹏程; 冷晔; 王聪

    2011-01-01

    目的 建立人尿样中非布司他浓度的液相色谱-质谱联用(LC-MS)测定法,并研究健康中国受试者口服非布司他片后非布司他的尿药排泄特征.方法 尿液样品酸化后用乙酸乙酯提取,进行LC-MS分析.色谱柱为Hedera ODS-2,流动相为甲醇-10 mmol·L-1的醋酸按水溶液(含0.05%甲酸)(70:30).12名健康受试者分别单次口服非布司他片80 mg(规格:80 mg)后,测定尿药浓度,计算尿药排泄参数,并进行统计分析.结果 12名健康受试者口服80 mg非布司他后,48 h内的尿药累积排泄量为(2.684±0.838) mg,累积排泄率为((3.4±1.0)%.男性与女性受试者间的累积排泄量和最大排泄速率无显著性差异.结论 非布司他在健康中国受试者体内的尿药排泄参数与已有文献报道的结果基本一致,且不存在性别差异.%OBJECTIVE To develop an LC-MS method for the determination of febuxostat in human urine sample, and to investigate the urinary excretion characteristics of febuxostat in healthy Chinese volunteers. METHODS After acidification, the urine sample was extracted with ethyl acetate and separated on a Hanbon Hedera ODS-2- C18 column, with a mobile phase of 10 inmol ? L-1 ammonium acetate buffer solution containing 0. 05% formic acid-methanol (30= 70). Twelve healthy volunteers were given single oral dose of 80 mg febuxostat The concentrations of febuxostat in urine were determined, and the pharmacokinetic parameters of febuxostat were calculated and compared between male and female volunteers by statistical analysis. RESULTS The accumulated amount of febuxostat excreted in urine in 48 h was (2. 684 ±0. 838 )mg. The accumulated excretion rate was (3.4 ± 1.0)%. The urinary excretion characteristics of febuxostat had no significant difference between the male and the female volunteers. CONCLUSION The urinary excretion characteristics of febuxostat in healthy Chinese volunteers is consistent with those reported in literature. There is no

  18. Histological Subtypes of Lung Cancer in Chinese Males from 2000 to 2012

    Institute of Scientific and Technical Information of China (English)

    ZOU Xiao Nong; LIN Dong Mei; WAN Xia; CHAO Ann; FENG Qin Fu; DAI Zhen; YANG Gong Huan; LV Ning

    2014-01-01

    Objective To characterize the histological and epidemiological features of male lung cancer patients in China. Methods The demographic and histological information about male lung cancer patients identified from 2000-01-01 to 2012-12-31, was collected from the Cancer Hospital of the Chinese Academy of Medical Sciences. Relative frequencies (RF) were estimated for major histological subtypes and compared according to the years of diagnosis and birth. Results The RF of adenocarcinoma (ADC) increased from 21.96% to 43.36% and the RF of squamous cell carcinoma (SCC) decreased from 39.11% to 32.23% from 2000 to 2012 in the 15 427 male lung cancer patients included in this study (Z=17.909, P Conclusion The increased RF of ADC in male lung cancer patients highlights the need for further investigation of the etiologic factors of these tumors. Smoke-free policies rather than modifying tobacco products should be enforced.

  19. Effects of Red Palm Oil on Serum Lipids and Plasma Carotenoids Level in Chinese Male Adults

    Institute of Scientific and Technical Information of China (English)

    JIAN ZHANG; CHUN-RONG WANG; AN-NA XUE; KE-YOU GE

    2003-01-01

    Objective Effects of red palm oil on major plasma carotenoids, tocopherol, retinol and serumlipids were evaluated when used in Chinese diet. Methods Red palm oil group (RPO) composed of 20 male subjects(aged 18-32) and soybean oil group (SBO) composed of 22 male subjects (aged18-32). Dietary fat provided about 28% of total calories, and the test oil accounted for about 60% of total dietary fat. In the 3 weeks of pretest period, diets were prepared with soybean oil, and then in the next 6 weeks subjects in each group consumed the diet prepared by test oil. Results Plasmaα-carotene, β-carotene and lycopene concentration of RPO group significantly increased at the time of interim (21 days) and of the end (42 days) (P<0.05), and α-tocopherol concentration significantly increased at the time of the end (42 days) in this study. Though Chinese plasma retinol level was relatively low when compared with that of Westerners, red palm oil diet showed no significant effect on adult Chinese plasma retinol level. Serum concentration of total cholesterol, triglyceride, high density lipoprotein cholesterol, apolipoprotein AI and apolipoprotein B of all subjects showed no significant changes in RPO group during the study. Conclusions The data in our study suggest that red palm oil is a good source of carotenoids and vitamin E when used in Chinese diet preparation, and it can significantly increase plasma concentration of α-carotene, β-carotene, lycopene andα-tocopherol.

  20. A qualitative study of Chinese male sexual minority students navigating heterosexism in Hong Kong secondary schools

    OpenAIRE

    Kwok, Kan, Diana; 郭勤

    2011-01-01

    This phenomenological qualitative study is informed by integrated theories including a social constructionist perspective on human sexuality, sexual identity development models, heterosexism with theoretical support of minority stress model and feminist theory. The aim was to uncover the lived experiences of 20 male sexual minority students navigating heterosexism in secondary schools, within the socio-cultural context of Hong Kong Chinese society. Due to the invisibil...

  1. Effect of grapefruit juice and food on the pharmacokinetics of pirfenidone in healthy Chinese volunteers: a diet-drug interaction study.

    Science.gov (United States)

    Hu, Jinqing; Shang, Dewei; Xu, Xinwen; He, Xiuling; Ni, Xiaojia; Zhang, Ming; Wang, Zhanzhang; Qiu, Chang; Deng, Shuhua; Lu, Haoyang; Zhu, Xiuqing; Huang, Wencan; Wen, Yuguan

    2016-06-01

    1. Ingestion of grapefruit juice and food could be factors affecting the pharmacokinetics of pirfenidone, a promising drug for treatment of idiopathic pulmonary fibrosis. 2. A randomized, open-label, three-period crossover study was carried out in 12 healthy Chinese male volunteers who were randomized to one of the three treatments: pirfenidone tablets (0.4 g) were orally administered to fasted or fed subjects, or with grapefruit juice. The washout period was 7 d. 3. Significantly reduced maximum plasma concentration (Cmax, 5.0 5 ± 1.39 versus 10.9 0 ± 2.94 mg·L(- 1)), modestly affected area-under-the-plasma concentration-time curve (AUC) from time zero to 12 h post dosing (AUC0-12 h, 21.8 9 ± 6.47 versus 26.1 6 ± 7.32 mg·h·L(- 1)) and delayed time to reach Cmax (Tmax) were observed in fed group compared with fasted group. Similar effects on Cmax (5.8 2 ± 1.23 versus 10.9 0 ± 2.94 mg·L(- 1)) and AUC0-12 h (modest but not statistically significant, 24.4 4 ± 7.40 versus 26.1 6 ± 7.32 mg·h·L(- 1)) were observed for grapefruit juice compared to fasted subjects. 4. Co-administration of pirfenidone with grapefruit juice resulted in modestly reduced overall oral absorption and significantly reduced peak concentrations compared to fasting, which was similar to effect of food ingestion. No adverse events were observed in the study, but relatively dramatic reduction of peak concentrations should raise concerns for clinical efficacy and safety. PMID:26407124

  2. 泛昔洛韦片在中国健康人体的生物等效性%Bioequivalence of famciclovir tablets in Chinese healthy volunteers

    Institute of Scientific and Technical Information of China (English)

    郭韶洁; 王淑民; 武峰; 李嘉静; 周辉; 赵秀丽

    2012-01-01

    目的 评价2种国产泛昔洛韦片在中国健康人体的生物等效性.方法 20名健康男性受试者随机交叉单剂量口服泛昔洛韦片试验药物或对照药物,各500 mg.用高效液相色谱法测定血浆中喷昔洛韦浓度;用DAS 2.0软件计算药代动力学参数,并对2种药物进行生物等效性评价.结果 试验药物和对照药物的药代动力学参数:Cmax分别为(2.60±0.53)和(3.50 ±0.84)mg·L-1;Tmax 分别为(0.99±0.45)和(2.50±0.23)h;t1/2分别为(2.52±0.32)和(2.50±0.23);AUC0-t分别为(9.10±1.61)和(9.61±1.70)mg·h·L-1.AUC0-t、AUC0-∞、Cmax的90%可信区间分别为90.7%~ 99.0%、90.9%~99.6%和70.4%~ 80.6%.试验药物相对于对照药物的生物利用度F为(95.29±9.85)%.结论 试验药物和对照药物生物等效.%Objective To evaluate the bioequivalent of test tablet and reference tablet of famciclovir in Chinese volunteers. Method In self -control and two - way crossover design, 20 healthy male volunteers were divided into two groups at random. Each subject was given 500 mg of the test tablet and reference tablet of famciclovir respectively at single dose. Plasma concentrations of penciclovir ( active metabolin) were determined by HPLC method. The pharmacokinetic parameters were calculated with DAS statistic software, the bioequivalent of famciclovir tablet evaluated as well. Results The main pharmacokinetic parameters of famciclovir test tablet and reference tablet were as follows: C^ ( 2. 60 ± 0. 53 ) , ( 3. 50 ±0.84) mg·L-1; Tmax,(0. 99 ±0.45), (2.50±0.23) h ; t1/2(2.52 ±0.32),(2. 50 ±0. 23) h; AUC0_t(9. 10 ±1.61), (9.61 ±1.70)mg ? H ? L~ , respectively. The relative bioavailability of famciclovir test tablet was (95. 29 ± 9. 85)% . Conclusion The test tablet and reference tablet of famciclovir were bioequivalent.

  3. Situation and Constitute Factors of Chinese University Volunteer Team%我国高校志愿者团队现状及构成因素

    Institute of Scientific and Technical Information of China (English)

    贾方; 包磊; 李娜

    2015-01-01

    In the early 1990s, the Communist Youth League system based volunteer corps of universities is becoming an im-portant part of the community volunteer organizations and civil coexistence, over the north and south, has become a national volunteer organization. With the 2008 Olympic Games volunteer team of volunteer opportunities, the rapid development and expansion, the university team of volunteers increasingly standardized, voluntary service to a number of areas to expand the scope of charitable, environmental protection, fire protection, stadium and so on. With the increase in the number of univer-sities and university voluntary associations of quantity, the development of university volunteer team there have been some problems, but also face many difficulties. Such as social support system is relatively backward, lack of national security laws and regulations, voluntary organizations universities lack self-construction, management mechanism is not perfect, funding and other operational difficulties, and therefore be analyzed from the current situation of volunteer team building, problem summary, constituting factor analysis, master of college students in our volunteer team, and can foster the development of Chinese Universities volunteer team building and student volunteers capabilities.%20世纪90年代初以共青团系统为主的我国高校志愿团逐渐成为与民间社区志愿者组织并存的一个重要组成部分,遍布大江南北,成为全国性志愿者组织。志愿者团队随着2008年奥运志愿的契机,迅速发展、壮大,高校志愿者队伍日趋规范化,志愿服务范畴拓展到了慈善、环保、消防、赛场等多个领域。随着高校志愿社团数量和大学生数量的增多,高校志愿者团队的发展出现了一些问题,也面临很多困难。例如社会支持体系相对落后、国家保障性法律法规的缺失、高校志愿服务组织自身建设不足、管理机制不健全、资金

  4. The Area of Secondary Hyperalgesia following Heat Stimulation in Healthy Male Volunteers: Inter- and Intra-Individual Variance and Reproducibility.

    Directory of Open Access Journals (Sweden)

    Morten Sejer Hansen

    Full Text Available Clinical pain models can be applied when investigating basic physiologic pain responses in healthy volunteers. Several pain models exist; however, only few have been adequately validated. Our primary aim with this prospective study was to investigate the intra- and inter-individual variation in secondary hyperalgesia elicited by brief thermal sensitization (45°C for 3 min in healthy volunteers.Fifty healthy volunteers were included. Areas of secondary hyperalgesia following brief thermal sensitization were investigated by 2 observers on 4 experimental days, with a minimum interval of 7 days. Additionally, heat pain detection threshold and pain during thermal stimulation (45°C for 1 min., and the psychological tests Pain Catastrophizing Scale and Hospital Anxiety and Depression Score were applied.For areas of secondary hyperalgesia, an intra-observer intra-person correlation of 0.85, 95% CI [0.78, 0.90], an intra-observer inter-person correlation of 0.03, 95% CI [0.00, 0.16], and a coefficient of variation of 0.17, 95% CI [0.14, 0.21] was demonstrated. Four percent of the study population had areas of secondary hyperalgesia both below the 1st and above the 3rd quartile considering all included participants. Heat pain detection threshold predicted area of secondary hyperalgesia with an adjusted R2 of 0.20 (P = 0.0006.We have demonstrated a low intra-individual, and a high inter-individual variation in thermally induced secondary hyperalgesia. We conclude that brief thermal sensitization produce secondary hyperalgesia with a high level of reproducibility, which can be applied to investigate different phenotypes related to secondary hyperalgesia in healthy volunteers.clinicaltrials.gov NCT02166164.

  5. Tolerability, pharmacokinetics and pharmacodynamics of CMAB001, an anti-CD11a antibody, in Chinese healthy volunteers and psoriatic patients

    Institute of Scientific and Technical Information of China (English)

    Xian-ping LI; Ya-jun GUO; Jing LI; Heng YAN; BO ZHOU; Bo-hua LI; Wei-zhu QIAN; Sheng HOU; Hao WANG; Fei HAO

    2012-01-01

    Aim:To evaluate the pharmacokinetics (PK),pharmacodynamics (PD) and primary tolerability of an anti-CD11a monoclonal antibody (CMAB001) in Chinese healthy volunteers and psoriatic patients.Methods:Two open-label studies were conducted.One was a parallel-group,single-center,dose-escalation test,including 24 healthy adult volunteers from 18 to 45 years in age.All subjects randomly received a single subcutaneous injection dose of 0.5,1.0,or 2.0 mg/kg.The other was a multiple-dose study:10 adult psoriatic patients were administered weekly subcutaneous injections of 1.0 mg/kg for 7 weeks.Results:CMAB001 was well tolerated in the single- and multiple-dose studies.Slow absorption was observed in both studies.In the single-dose study,the concentration of CMAB001 reached its highest level 2 d later after the injection,and the Cmax increased in an approximate dose-proportionate manner,while the area under curve (AUC) showed much greater than dose-proportionate increase.In the multiple-dose study,the steady-state serum concentration level was attained following the 4th injection.Conclusion:CMAB001 exhibited a nonlinear pharmacokinetic profile over the dose range from 0.5 to 2.0 mg/kg,and was well tolerated in healthy volunteers and psoriatic patients.

  6. Bioequivalence evaluation of secnidazole tablets in healthy male volunteers%塞克硝唑片剂健康人体生物等效性研究

    Institute of Scientific and Technical Information of China (English)

    师少军; 李忠芳; 万元胜; 陈华庭; 曾繁典

    2007-01-01

    AIM: To compare the bioavailability of the test and reference formulation of secnidazole (2 g) tablets under fasting conditions. METHODS: This bioequivalence study was carried out in 20 healthy male Chinese volunteers according to a single dose, two-sequence, crossover randomized design. Fifteen blood samples per period were collected over 96 h, and plasma secnidazole concentrations were determined by locally validated high performance liquid chromatography (HPLC) assay and pharmacokinetic parameters were analyzed by the non-compartmental and compartmental methods. RESULTS: Plasma concentration-time profiles were adequately described by a one-compartment open model with first-order absorption. The main pharmacokinetic parameters of secnidazole test and reference tablets were as follows: tmax were (2.30±1.06) and (2.28±1.10) h, Cmax were (49.63±6.35) and (46.17±4.24) mg/L, t1/2 were (28.84±3.41) and (29.05±4.01) h, AUC0-96 were (1832.06±180.15) and (1847.14±204.14) mg·h-1·L-1, respectively. The relative bioavailability of test tablets was (99.99±11.92)%. CONCLUSION: The results indicate that the two formulations of secnidazole tablets are bioequivalent in the rate and extent of absorption.%目的:研究塞克硝唑试验片与参比片的生物利用度,并进行生物等效性评价.方法:20名健康男性志愿者单剂量口服塞克硝唑试验或参比制剂各2 g;采用反相高效液相色谱法测定其血药浓度.结果:人体药动学研究表明,口服塞克硝唑片的药-时曲线符合一级吸收的单房室模型.试验片与参比片的主要药代动力学参数:tmax分别为(2.30±1.06)和(2.28±1.10) h;Cmax分别为(49.63±6.35)和(46.17±4.24) mg/L;t1/2 分别为(28.84±3.41)和(29.05±4.01) h;AUC0-96 分别为(1832.06±180.15)和(1847.14±204.14) mg·h-1·L-1;相对生物利用度为(99.99±11.92)%.结论:塞克硝唑片两种制剂具有生物等效性.

  7. Cytological Observation of Microsporogenesis in Male-Sterile Lines of Chinese Pink (Dianthus chinensis L.)

    Institute of Scientific and Technical Information of China (English)

    FU Xiao-peng; HU Jin-yi; HU Hui-rong; BAO Man-zhu

    2008-01-01

    This study addressed the differences in microsporogenesis between male sterile and fertile lines of Chinese pink. The microsporogenesis processes of male sterile and fertile lines were histologically examined in squashed pollen grains and in paraffin embedded sections. A stable male-sterile line (H-37B) was obtained following six generations of inbreeding in a self-fertile line, followed by two generations of backcrossing. In the corresponding fertile line, development of the mature pollen grains was followed through the initiation of the sporogenous cell, microsporocyte formation, and the tetrad developmental period. In the male-sterile line, abortion of the developing pollen grains was observed to take place at various stages, namely, sporogenous cell growth, mother cell meiosis, and tetrad transformation to the uninuclear state. The pollen grains of the fertile line were spheroid, turgid, and viable. By contrast, the male-sterile line produced pollen that was irregular in shape, empty, and nonviable. The abortion of the microspore in the male-sterile line appeared to relate to abnormal growth of the tapetum layer.

  8. Hair as an indicator of the body content of polonium in humans: preliminary results from study of five male volunteers

    International Nuclear Information System (INIS)

    The radionuclide 210Po is of importance from a radiation protection view and has properties that cause special problems when attempting to determine the body content in humans. Estimates have traditionally been made from either urine and/or fecal samples, which require a time-consuming radiochemical preparation before alpha spectrometric determination. In order to find a more simple and less labor intensive method hair has been used as a bioindicator and investigated in this study. The relationship between intake and excretion in hair has been estimated in five volunteers who ingested radioactive polonium (209Po as a bio-tracer for 210Po) in well determined quantities. Four of the volunteers were given 5–10 Bq 209Po in a single intake (acute intake) and one volunteer has ingested a daily intake of 58.7 mBq 209Po for a period of 180 d. Human hair was found to reflect the daily clearance of ingested polonium peaking at 0.001–0.01% d−1 of the ingested amount, thereafter decreasing mono-exponentially, corresponding to a biological half-time of 10–20 days. For the case of protracted intake a mono-exponential build-up was observed with a half-time of 40 ± 5 d. In addition, after cessation of intake, a short-term component (74%) with a biological half-time of 16 ± 4 d, and a long-term component (26%) with a half-time of 93 ± 53 d were observed. It is concluded that hair can be used to detect not only the amount of ingested polonium but also whether the intake was protracted or acute. - Highlights: • After single intakes polonium is excreted in hair with biological half-times (range 15–30 days). • Polonium concentration vs position in hair strand reflects the intake history of subject. • For acute intakes peak hair concentration or daily excretion can be related to the amount of intake. • Protracted intakes of polonium result in an increase in Po concentration in hair, reaching equilibrium after 180 days. • Bi-exponential decay of

  9. Association of nicotinic acetylcholine receptor subunit alpha-4 polymorphisms with smoking behaviors in Chinese male smokers

    Institute of Scientific and Technical Information of China (English)

    CHU Cheng-jing; YANG Yan-chun; WEI Jin-xue; ZHANG Lan

    2011-01-01

    Background It has been reported that the nicotinic acetylcholine receptor subunit a4 gene (CHRNA4) might be associated with smoking behaviors in the previous studies. Up to now, there are few reports on the relationship between CHRNA4 and smoking initiation. In this study, we tried to explore the role of two polymorphisms in CHRNA4 (rs 1044396 and rs 1044397) in smoking initiation and nicotine dependence in Chinese male smokers.Methods Nine hundred and sixty-six Chinese male lifetime nonsmokers and smokers were assessed by the Fagerstr(o)m test for nicotine dependence (FTND), smoking quantity (SQ) and the heaviness of smoking index (HSI). All subjects were divided into four groups based on their tobacco use history and the FTND scores. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed to find two polymorphisms of CHRNA4 in these subjects.Results The x2 test showed that rs1044396 was significantly associated with smoking initiation (x2=4.65, P=0.031),while both rs1044396 and rs1044397 were significantly associated with nicotine dependence (x2=5.42, P=0.020; x2=758,P=0.005). Furthermore, the T-G (3.9%) haplotype of rs1044396-rs1044397 showed significant association with smoking initiation (x2=6.30, P=0.012) and the C-G haplotype (58.9%) remained positive association with nicotine dependence (x2=8.64, P=0.003) after Bonferroni correction. The C-G haplotype also significantly increased the HSI (P=0.002) and FTND scores (P=0.001) after Bonferroni correction.Conclusion These findings suggest that CHRNA4 may be associated with smoking initiation and the C-G haplotype of rs1044396-rs1044397 might increase the vulnerability to nicotine dependence in Chinese male smokers.

  10. Hair as an indicator of the body content of polonium in humans: Preliminary results from study of five male volunteers

    DEFF Research Database (Denmark)

    Rääf, C.L.; Holstein, H.; Holm, E.;

    2015-01-01

    The radionuclide 210Po is of importance from a radiation protection view and has properties that cause special problems when attempting to determine the body content in humans. Estimates have traditionally been made from either urine and/or fecal samples, which require a time-consuming radiochemi......The radionuclide 210Po is of importance from a radiation protection view and has properties that cause special problems when attempting to determine the body content in humans. Estimates have traditionally been made from either urine and/or fecal samples, which require a time......-consuming radiochemical preparation before alpha spectrometric determination. In order to find a more simple and less labor intensive method hair has been used as a bioindicator and investigated in this study. The relationship between intake and excretion in hair has been estimated in five volunteers who ingested...

  11. The relationship between air layers and evaporative resistance of male Chinese ethnic clothing.

    Science.gov (United States)

    Wang, Faming; Peng, Hui; Shi, Wen

    2016-09-01

    In this study, the air layer distribution and evaporative resistances of 39 sets of male Chinese ethnic clothing were investigated using a sweating thermal manikin and the three-dimensional (3D) body scanning technique. Relationships between the evaporative resistance and air layers (i.e., air gap thickness and air volume) were explored. The results demonstrated that the clothing total evaporative resistance increases with the increasing air gap size/air volume, but the rate of increase gradually decreases as the mean air gap size or the total air volume becomes larger. The clothing total evaporative resistance reaches its maximum when the average air gap size and the total air volume are 41.6 mm and 69.9 dm(3), respectively. Similar general trends were also found between local mean air gap size and clothing local evaporative resistance at different body parts. However, different body parts show varied rates of increase and decrease in the local evaporative resistance. The research findings provide a comprehensive database for predicting overall and local human thermal comfort while wearing male Chinese ethnic clothing. PMID:27184328

  12. The effect of acute exogenous melatonin on P50 suppression in healthy male volunteers stratified for low and high gating levels

    DEFF Research Database (Denmark)

    Ucar, Ebru; Lehtinen, Emilia K; Glenthøj, Birte Y;

    2012-01-01

    Sensory gating is frequently found to be disturbed in patients with schizophrenia. In addition, a disruption of the circadian rhythm together with a low nocturnal melatonin output is regularly found in these patients. Since there is some evidence that a brief period of sleep normalizes sensory...... gating in schizophrenia patients, it is conceivable that their disrupted melatonin level may contribute to the deficits in P50 suppression. In this initial study, the effects of acutely administered melatonin on sensory gating in healthy subjects were investigated. In a double-blind placebo......-controlled crossover design, 21 healthy male volunteers were administered melatonin (4 mg) or placebo, after which they were tested in a P50 suppression paradigm. In the group as a whole, melatonin did not affect P50 suppression. However, melatonin increased the P50 ratio in the individuals with high baseline...

  13. Genetic variants in TP53 and MDM2 associated with male infertility in Chinese population

    Institute of Scientific and Technical Information of China (English)

    Cong Huang; Wei Liu; Gui-Xiang Ji; Ai-Hua Gu; Jian-Hua Qu; Ling Song; Xin-Ru Wang

    2012-01-01

    The TP53,a transcriptional regulator and tumor suppressor,is functionally important in spermatogenesis.MDM2 is a key regulator of the p53 pathway and modulates p53 activity.Both proteins have been functionally linked to germ cell apoptosis,which may affect human infertility,but very little is known on how common polymorphisms in these genes may influence germ cell apoptosis and the risk of male infertility.Thus,this study was designed to test whether three previously described polymorphisms 72Arg>Pro (rs1042522) and the Ex2+ 19C>T (rs2287498) in TP53,and the 5' untranslated region (5' UTR) 309T>G (rs937283) in MDM2,are associated with idiopathic male infertility in a Chinese population.The three polymorphisms were genotyped using OpenArray assay in a hospital-based case-control study,including 580 infertile patients and 580 fertile controls.Our analyses revealed that TP53 Ex2+ 19C>T and MDM2309T>G polymorphisms are associated with mate infertility.Furthermore,we detected a nearly statistically significant additive interaction between TP53 rs2287498 and MDM2 rs937283 for the development of male.infertility (Pinteraction=0.055).In summary,this study found preliminary evidence,demonstrating that genetic variants in genes of the TP53 pathway are risk factors for male infertility.

  14. The effect of acute alcohol intoxication on gut wall integrity in healthy male volunteers; a randomized controlled trial.

    Science.gov (United States)

    de Jong, W J; Cleveringa, A M; Greijdanus, B; Meyer, P; Heineman, E; Hulscher, J B

    2015-02-01

    The aim of the study is to determine the effect of acute alcohol consumption on enterocytes. Chronic alcohol consumption has been known to induce a decrease in gut wall integrity in actively drinking alcoholics and patients with alcohol-induced liver disease. Data on the extent of the damage induced by acute alcohol consumption in healthy human beings is scarce. Studies show that heavy incidental alcohol consumption is a growing problem in modern society. Data on this matter may provide insights into the consequences of this behavior for healthy individuals. In a randomized clinical trial in crossover design, 15 healthy volunteers consumed water one day and alcohol the other. One blood sample was collected pre-consumption, five every hour post-consumption, and one after 24 h. Intestinal fatty acid binding protein (I-FABP) was used as a marker for enterocyte damage. Liver fatty acid binding protein (L-FABP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyl transferase (GGT) were used as markers for hepatocyte damage. Lipopolysaccharide binding protein (LBP) and soluble CD14 (sCD14) were used as a measure of translocation. Interleukin-6 (IL-6) was used to assess the acute inflammatory response to endotoxemia. Alcohol consumption caused a significant increase in serum I- and L-FABP levels, compared to water consumption. Levels increased directly post-consumption and decreased to normal levels within 4 h. LBP, sCD14, and IL-6 levels were not significantly higher in the alcohol group. Moderate acute alcohol consumption immediately damages the enterocyte but does not seem to cause endotoxemia. PMID:25559494

  15. Association of single nucleotide polymorphism Rs2236518 in PRDM16 gene with BMI in Chinese males

    Institute of Scientific and Technical Information of China (English)

    Hua YUE; Jin-wei HE; Yao-hua KE; Hao ZHANG; Chun WANG; Wei-wei HU; Jie-mei GU

    2013-01-01

    PRD1-BF-1-RIZ1 homologous domain containing protein-16 (PRDM16) is a cell-autonomous transcriptional component that stimulates the development of brown fat cells.The aim of this study was to investigate the contribution of genetic variants of PRDM16 to obesity-related phenotype variations in Chinese.Methods:A total of 3204 subjects (consisting of 400 male-offspring nuclear families,401 female-offspring nuclear families,and 729 unrelated older males) were recruited.Ten tag single nucleotide polymorphisms (SNPs) within the PRDM16 gene were genotyped using multiplex quantitative real-time PCR by Taqman assay.Body compositions were measured by dual-energy X-ray absorptiometry (DXA).The associations of the SNPs with the obesity-related phenotypes were analyzed using the quantitative transmission disequilibrium test (QTDT),GLM-ANOVA and PLINK statistical methods.Results:Rs2236518 was the only SNP that was associated with BMI in young (aged 20-40 years) males (P=0.011) using QTDT,and in the older men (aged 50-80 years) (P=0.03) using GLM-ANOVA.No significant associations were detected in the females.Nor was a relationship found between any haplotype and obesity-related phenotypes.When PLINK was used,no significant relationship was detected between 10 SNPs and obesity-related phenotypes in any of the studied cohorts.Conclusion:Rs2236518 is associated with BMI in the young males (using QTDT),and the older males (using GLM-ANOVA).However,the result is not confirmed using PLINK.The discrepancy needs to be further addressed.

  16. Student volunteering - gender differences

    OpenAIRE

    Helga Maškarin Ribarić; Lorena Dadić; Martina Nađ

    2014-01-01

    Purpose – A high unemployment rate of young highly-educated people as a consequence of economic crisis is one of the main problems the Croatian economy is facing today. In order to increase their future competitiveness on the labour market, students are encouraged to involve themselves in different types of volunteering activities. The purpose of this paper is to determine if there are differences in attitudes towards volunteering between male and female students. These differences should be ...

  17. Growth hormone (GH) activity is associated with increased serum oestradiol and reduced Anti-Müllerian Hormone in healthy male volunteers treated with GH and a GH antagonist

    DEFF Research Database (Denmark)

    Andreassen, M; Frystyk, Jan; Faber, J;

    2013-01-01

    Growth hormone (GH) and insulin-like growth factor I (IGF-I) receptors are present on pituitary gonadotrophs and on testicular Leydig and Sertoli cells. Thus, the GH/IGF-I system may modulate the pituitary-gonadal axis in males. This is a randomized cross-over study. Eight healthy male volunteers...... luteinizing hormone (LH), follicle-stimulating hormone, testosterone, oestradiol, sex hormone-binding globulin, inhibin B and Anti-Müllerian Hormone (AMH) were measured. During GH treatment, IGF-I increased [(median (IQR)] 166 (162-235) vs. 702 (572-875) μg/L, p <0.001) together with oestradiol [(mean ± SD...... (160-290) vs. 106 (97-157) μg/L, p = 0.001) and oestradiol (86 ± 28 vs. 79 ± 25 pm, p = 0.060) decreased. No significant changes or trends in the other reproductive hormones occurred during the two treatment regimens. GH/IGF-I activity was positively associated with serum oestradiol, suggesting that GH...

  18. Pharmacokinetic interaction between udenafil and dapoxetine: a randomized, open-labeled crossover study in healthy male volunteers

    Directory of Open Access Journals (Sweden)

    Kim YH

    2015-02-01

    Full Text Available Yo Han Kim,1 Hee Youn Choi,1 Shi Hyang Lee,1 Hae Sun Jeon,1 Hyeong-Seok Lim,1 Mi Young Bahng,2 Kyun-Seop Bae1 1Department of Clinical Pharmacology and Therapeutics, Asan Medical Center, College of Medicine, University of Ulsan, 2Clinical Development Department, Dong-A ST Co, Ltd, Seoul, Republic of Korea Background: “Udenafil” is a phosphodiesterase-5 inhibitor indicated for erectile dysfunction. “Dapoxetine” is a serotonin transport inhibitor indicated for premature ejaculation. The aim of the study reported here was to investigate the pharmacokinetic drug interaction between udenafil and dapoxetine in healthy male subjects. Methods: An open-label, three-treatment, six-sequence, three-period crossover study was performed in healthy male subjects. In varying sequences, each subjects received single oral doses of udenafil 200 mg, dapoxetine 60 mg, and both treatments. The periods were separated by a washout period of 7 days. Serial blood samples were collected up to 48 hours after dosing. The plasma concentrations of udenafil and dapoxetine were determined using a validated liquid chromatography-tandem mass spectrometry method. Pharmacokinetic parameters were obtained by non-compartmental analysis. Tolerability was assessed throughout the study. Results: Twenty-three healthy subjects completed the study. The geometric mean ratios of the area under the plasma concentration–time curve from time 0 to last measurable time point and measured peak plasma concentration for udenafil were 0.923 (90% confidence interval [CI]: 0.863–0.987 and 0.864 (90% CI: 0.789–0.947, respectively. The geometric mean ratios of the area under the plasma concentration–time curve from time 0 to last measurable time point and measured peak plasma concentration for dapoxetine were 1.125 (90% CI: 1.044–1.213 and 0.837 (90% CI: 0.758–0.925, respectively. There were no serious adverse events reported, and none of the subjects dropped out due to adverse events

  19. Single Whole-Body Cryostimulation Procedure versus Single Dry Sauna Bath: Comparison of Oxidative Impact on Healthy Male Volunteers

    Directory of Open Access Journals (Sweden)

    Paweł Sutkowy

    2015-01-01

    Full Text Available Exposure to extreme heat and cold is one of the environmental factors whose action is precisely based on the mechanisms involving free radicals. Fluctuations in ambient temperature are among the agents that toughen the human organism. The goal of the study was to evaluate the impact of extremely high (dry sauna, DS and low (whole-body cryostimulation, WBC environmental temperatures on the oxidant-antioxidant equilibrium in the blood of healthy male subjects. The subjects performed a single DS bath (n=10; 26.2 ± 4.6 years and a single WBC procedure (n=15; 27.5 ± 3.1 years. In the subjects’ blood taken immediately before and 20 min after the interventions, the activity of superoxide dismutase (SOD, catalase (CAT, and glutathione peroxidase (GPx and the concentration of thiobarbituric acid reactive substances in erythrocytes (TBARSer and blood plasma (TBARSpl were determined. Single WBC and DS procedures induced an increase in the activity of SOD and GPx, as well as SOD and CAT, respectively. The SOD activity was higher after WBC than after DS. Extremely high and low temperatures probably induce the formation of reactive oxygen species in the organisms of healthy men and, therefore, disturb the oxidant-antioxidant balance.

  20. Plasma riboflavin is a useful marker for studying riboflavin requirement in Chinese male adults.

    Science.gov (United States)

    Guo, Changjiang; Wei, Jingyu; Gao, Weina; Pu, Lingling; Tang, Zhenchuang; Li, Lingyan

    2016-06-01

    Urinary riboflavin excretion and erythrocyte glutathione reductase activation coefficient are frequently applied in determining riboflavin requirement. Previously, we found that plasma riboflavin is a sensitive marker in the assessment of riboflavin status in rat models. Here, we hypothesize that plasma riboflavin is a useful maker in studying riboflavin requirement. This study examines the changes of fasting plasma riboflavin and urinary riboflavin excretion in response to different riboflavin intake levels in Chinese male adults. The estimated average requirement (EAR) of riboflavin was extrapolated. Seventy-eight participants were randomly divided into the control and 5 riboflavin-supplemented groups. A 6-week riboflavin supplementation was performed at the doses of 0, 0.2, 0.4, 0.6, 0.8, or 1.0 mg daily. The energy expenditure was 15.4 ± 1.9 MJ/d, as estimated by the 24-hour physical activity recording method. Dietary riboflavin intake was 1.0 ± 0.2 mg/d, based on chemical analysis. The fasting plasma riboflavin was increased significantly in a dose-dependent manner when the supplemented riboflavin exceeded 0.4 mg/d and the EAR of riboflavin was suggested to be between 1.3 and 1.5 mg/d. In addition, we found a significant increase in fasting urinary riboflavin excretion when the supplemented riboflavin exceeded 0.6 mg/d. The critical point was calculated as 1.4 mg/d, based on the intersecting point of the 2 regression lines at lower and higher riboflavin intakes. These findings demonstrate that plasma riboflavin is a sensitive marker for riboflavin status, and the EAR of riboflavin for Chinese male adults is 1.4 mg. PMID:27188899

  1. Factors influencing Chinese male's willingness to undergo circumcision: a cross-sectional study in western China.

    Directory of Open Access Journals (Sweden)

    Xiaobo Yang

    Full Text Available BACKGROUND: Male circumcision (MC has been shown to reduce the risk of female to male transmission of HIV. The goal of this survey was to explore the acceptability of MC among the Chinese and to identify factors associated with circumcision preference. METHODS: A cross-sectional survey was conducted between September 2009 and December 2010. We interviewed 2,219 male community participants, from three high HIV prevalence provinces in western China. A structured questionnaire was used to collect data on MC knowledge, willingness to accept MC, reasons to accept or refuse MC, and sexual behaviors and health. For those who refused MC, a health education intervention providing information on the benefits of circumcision was conducted. We used multiple logistic regression models to identify factors associated with the acceptability of MC. RESULTS: Of the respondents (n = 2,219, 44.6% (989/2,219 reported they would accept MC for the following reasons: promotion of female partners' hygiene (60.3%, redundant foreskin (59.4%, prevention of penile cancer (50.2%, enhanced sexual pleasure (41.4%, and protection against HIV and STDs (34.2%. The multivariable logistic regression showed that five factors were associated with MC willingness: long foreskin (OR = 15.98, residing in Xinjiang province (OR = 3.69, being younger than 25 (OR = 1.60, knowing hazards of redundant foreskin (OR = 1.78, and having a friend who underwent circumcision (OR = 1.36. CONCLUSION: The acceptability of male circumcision was high among the general population in China. Our study elucidates the factors associated with circumcision preference and suggests that more health education campaigns about positive health effects are necessary to increase the MC rate in China.

  2. Pharmacokinetics and bioavailability study of two ondansetron oral soluble film formulations in fasting healthy male Chinese volunteers

    Directory of Open Access Journals (Sweden)

    Zhu YB

    2015-08-01

    Full Text Available Yubing Zhu,1 Qian Zhang,1 Jianjun Zou,2 Meng Wan,1 Zheng Zhao,1 Junrong Zhu1 1Department of Pharmacy, 2Laboratory of Clinical Pharmacology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China Background: Ondansetron oral soluble film is designed to be applied on top of the tongue without requiring water to aid dissolution or swallowing, which is especially fitting for nausea and vomiting patients.Purpose: This study was conducted to compare the bioavailability of two 8 mg ondansetron oral soluble film formulations.Patients and methods: This randomized, open-label, two-period crossover study was performed under fasting conditions. A total of ten eligible subjects were randomly assigned at a 1:1 ratio to receive a single 8 mg dose of the test and reference ondansetron oral soluble film formulations, followed by a 1-week washout period and administration of the alternate formulation. The concentrations of ondansetron were assayed using an liquid chromatograph-mass spectrometer/mass spectrometer (LC-MS/MS method. For analysis of pharmacokinetic properties, including the peak concentration of Tmax (Cmax, AUC from time 0 (baseline to t hours (AUC0–t, and AUC from baseline to infinity (AUC0–∞, blood samples were obtained at intervals over the 24-hour period after studying drug administration. Tolerability was assessed by monitoring vital signs and laboratory tests (hematology, blood biochemistry, hepatic function, and urinalysis and by questioning subjects about adverse events.Results: The mean (standard derivation [SD] relative bioavailability was 96.5 (23.7%. The 90% confidence intervals (CIs for the log-transformed ratios of Cmax and AUC0–t were 84.71%–103.28% and 91.38%–108.60%, respectively (P>0.05. Similar results were found for the data without log-transformation. No statistically significant differences were found based on analysis of variance. No significant adverse events occurred or were reported during the study.Conclusion: As the 90% CIs based on the differences between the test and reference formulation were within the 80%–125% range for both the Cmax and AUC0–t, we concluded that the two formulations were bioequivalent with respect to the rate or the extent of absorption. Both formulations are well tolerated. Keywords: ondansetron, oral soluble film, LC-MS/MS, bioequivalence  

  3. Improved sexual behavior in male rats treated with a Chinese herbal extract: hormonal and neuronal implications

    Institute of Scientific and Technical Information of China (English)

    Paola Zanoli; Augusta Benelli; Manuela Zavatti; Marianna Rivasi; Claudia Baraldi; Mario Baraldi

    2008-01-01

    Aim: To investigate the influence of an extract obtained from five Chinese medicinal plants on sexual behavior of adult male rats. Methods: The extract was administered at doses of 30, 60 and 120 mg/kg by oral gavage, acutely (one time, 45 rain before mating test) or subchronically (daily for 10 days) in sexually potent and sexually sluggish/impo-tent rats. Sexual behavior, serum levels of luteinizing hormone (LH) and testosterone (T) were evaluated in treated rats and compared with controls receiving vehicle. The effect of the extract on central dopaminergic neurotransmis-sion was assessed in the nucleus accumbens using a microdialysis technique. Results: In sexually potent rats, both acute and subchronic treatment with the extract dosed at 30 and 60 mg/kg reduced mount latency and intromission latency. In sluggish/impotent rats, the acutely administered extract at the dose of 60 mg/kg shortened ejaculation latency, whereas subchronically administered at the doses of 30 and 60 mg/kg, reduced mount, intromission and ejaculation latencies, increasing also the percentage of mounting and ejaculating rats. The extract dosed at 60 mg/kg significantly increased LH and T following acute and subchronic administration and increased 3,4-dihydroxyphenylacetic acid levels in the nucleus accumbens, 30 rain after the acute administration. Conclusion: The improvement in both appetitive and consummatory components of sexual behavior observed in male rats treated with the extract could be scribed to increased serum T level in parallel with the activation of the central dopaminergic system.

  4. LC-MS/MS determination and urinary excretion study of seven alkaloids in healthy Chinese volunteers after oral administration of Shuanghua Baihe tablets.

    Science.gov (United States)

    Cheng, Minlu; Liu, Ruijuan; Wu, Yao; Gu, Pan; Zheng, Lu; Liu, Yujie; Ma, Pengcheng; Ding, Li

    2016-01-25

    An LC-MS/MS method was developed and validated for the simultaneous determination of magnoflorine, berberrubine, jatrorrhizine, coptisine, epiberberine, palmatine and berberine in human urine. The sample preparation procedure involved the four-fold dilution of the urine samples with acetonitrile/water (1:3, v/v). The chromatographic separation was achieved on a Hedera ODS-2 column under gradient elution at a flow rate of 0.4 mL/min with acetonitrile and water containing 0.5% formic acid as the mobile phase. The mass detection was performed in the positive mode. Calibration curves of the seven alkaloids showed good linearity (correlation coefficients>0.9973) over their concentration ranges. To meet the requirements of urinary excretion study for each alkaloid in human, the lower limit of quantification was set at different values from 0.05063 ng/mL to 2.034 ng/mL for the seven alkaloids, respectively. The intra- and inter-batch precision and accuracy were all within ± 15%. No matrix effect was observed for the analytes. The validated method was applied to the excretion study for the seven alkaloids in healthy Chinese volunteers after oral administration of Shuanghua Baihe tablets. The average 72 h cumulative urinary excretion of magnoflorine, berberrubine, jatrorrhizine, coptisine, epiberberine, palmatine and berberine accounted for 1.81%, 0.27%, 0.29%, 0.046%, 0.027%, 0.010% and 0.021% of the respective administered dose. PMID:26519688

  5. Chinese female breast cancer patients show a better overall survival than their male counterparts

    Institute of Scientific and Technical Information of China (English)

    XIA Liang-ping; ZHOU Fei-fei; GUO Gui-fang; WANG Fang; WANG Xi; YUAN Zhong-yu; ZHANG Bei

    2010-01-01

    Backgroud It is not clear if there is a difference in prognosis between male breast cancer (MBC) and female breast cancer (FBC) patients. The aim of this study was to compare the prognosis of MBC and FBC patients in China and the prognosis of MBC and their corresponding postmenopausal FBC patients.Methods Thirty-five MBC patients who were treated at the Sun Yat-sen University Cancer Center between 1969 and 2004 were enrolled in the study. Seventy FBC patients who were matched with the MBC patients for TNM stage, year of diagnosis, and age at diagnosis were simultaneously enrolled in the study. A second group comprising 18 MBC patients and their corresponding 36 matched postmenopausal FBC patients were also enrolled. The whole group and the postmenopausal groups were compared for five- and ten-year survivals. Results All the factors that could potentially affect prognosis were comparable among the groups except more FBC than MBC patients underwent endocrine therapy and a modified radical mastectomy. The 5- and 10-year survivals in the whole group were 81.6% and 60.3% for men and 90.7% and 73.5% for women (P=0.02). The 5- and 10-year survival in the postmenopausal group was 82.5% and 100% for men and 66.0% and 85.9% for women (P=0.159).Conclusions Chinese FBC patients had a better prognosis than Chinese MBC patients. However, MBC patients and their corresponding postmenopausal FBC patients had a similar prognosis.

  6. Relationship of carotid intima-media thickness and duration of vegetarian diet in Chinese male vegetarians

    Directory of Open Access Journals (Sweden)

    Liu Chang-Qin

    2011-09-01

    Full Text Available Abstract Objective Many studies have shown that vegetarian diet has beneficial effects on the prevention of cardiovascular diseases. However, the effect of vegetarian diet on carotid intima-media thickness (IMT, as well as the association between IMT and duration of vegetarian diet, are still unclear. The present study aims to investigate the influence of duration of vegetarian diet on cardiovascular risk factors, and more importantly on IMT among Chinese vegetarians. Methods One hundred and seventy-one Chinese male vegetarians were screened for metabolic profile, cardiovascular risk and carotid IMT. They were compared with 129 age-matched omnivores recruited from a community-based health project. The effects of confounding factors were adjusted by stepwise logistic regression analysis. Results Compared to the omnivores, the vegetarians had lower BMI, weight, systolic blood pressure and diastolic blood pressure. Also, the levels of triglyceride, total cholesterol, HDL-Cholesterol, LDL-Cholesterol, ApoA1, ApoB, uric acid, albumin and γ-glutamyltransferase were significantly reduced in vegetarians. Omnivores had significantly higher fasting blood glucose than that of vegetarians. However, there were no differences in fasting insulin, C-reactive protein and HOMA-IR between the two groups. IMT was thinner in the vegetarian group than in the omnivore group (0.59 ± 0.16 vs. 0.63 ± 0.10 cm, P 11 years, those in tertile 1 ( Conclusion A decrease in multiple cardiovascular risk factors such as BMI, blood pressure and lipid profile was associated with vegetarian diet. Moreover, taking a low-calorie, low-protein, or vegetarian diet might have great beneficial effects on IMT through improved lipid profile, and the beneficial effects appeared to be correlated with the duration of vegetarian diet.

  7. Polymorphisms of alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 and colorectal cancer risk in Chinese males

    Institute of Scientific and Technical Information of China (English)

    Chang-Ming Gao; Keitaro Matsuo; Nobuyuki Hamajima; Kazuo Tajima; Toshiro Takezaki; Jian-Zhong Wu; Xiao-Mei Zhang; Hai-Xia Cao; Jian-Hua Ding; Yan-Ting Liu; Su-Ping Li; Jia Cao

    2008-01-01

    AIM: To evaluate the relationship between drinking and polymorphisms of alcohol dehydrogenase 2 (ADH2) and/or aldehyde dehydrogenase 2 (ALDH2) for risk of colorectal cancer (CRC) in Chinese males.METHODS: A case-control study was conducted in 190 cases and 223 population-based controls.ADH2 Arg47His (G-A) and ALDH2 Glu487Lys (G-A) genotypes were identified by PCR and denaturing high-performance liquid chromatography (DHPLC).Information on smoking and drinking was collected and odds ratio (OR) was estimated.RESULTS: The ADH2 A/A and ALDH2 G/G genotypes showed moderately increased CRC risk. The age- and smoking-adjusted OR for ADH2 A/A relative to G/A and G/G was 1.60 (95% CI=1.08-2.36), and the adjusted OR for ALDH2 G/G relative to G/A and A/A was 1.79 (95% CI=1.19-2.69). Significant interactions between ADH2,ALDH2 and drinking were observed. As compared to the subjects with ADH2 G and ALDH2 A alleles, those with ADH2 A/A and ALDH2 G/G genotypes had a significantly increased OR (3.05, 95% CI= 1.67-5.57). The OR for CRC among drinkers with the ,4DH2 A/A genotype was increased to 3.44 (95% CI= 1.84-6.42) compared with non-drinkers with the ADH2 G allele. The OR for CRC among drinkers with theALDH2 G/G genotype was also increased to 2.70 (95% CI= 1.57-4.66) compared with non-drinkers with the ALDH2 A allele.CONCLUSION: Polymorphisms of the ADH2 and ALDH2 genes are significantly associated with CRC risk. There are also significant gene-gene and geneenvironment interactions between drinking and ADH2 and ALDH2 polymorphisms regarding CRC risk in Chinese males.

  8. 中美大学生志愿服务激励机制的比较研究%A Comparative Study of the Inspirational Mechanism of Volunteer Services Between Chinese and American College Students

    Institute of Scientific and Technical Information of China (English)

    龙永红

    2011-01-01

    从来源上看,国家的合法性认同、高校的创新管理、志愿组织与志愿者之间的关系是大学生志愿服务激励机制的重要方面。中美大学生志愿服务激励机制的比较结果表明:志愿服务是一种“有限自愿”行为,需要强化国家在法律规章合法性建构方面的主导性,提升大学生志愿服务在国家社会生活中的显著度;大学生志愿服务行动呈“弥散分布结构”,需要高校建立统一认证考评体系,并将其纳入课程学分、就业指标与素质教育的框架;志愿组织培育好与志愿者的关系,以平等沟通与深度参与方式开发志愿服务的多元活动网络,有助于从内在的满足感与成就感方面激发大学生的志愿热情。%The inspirational mechanism of volunteer services among college students originates from the recognition of the legitimacy from state, the creative management in higher educational institutions and the relationship between the volunteer organizations and volunteers. The comparison of the inspirational mechanism of volunteer services between Chinese and American college students shows that volunteer services is a kind of limited voluntary behaviors, which means that state power should take the leadership in the construction of a legalized framework of laws and regulations so as to highlight the importance of volunteer services of college students in the social life of the whole country. The scattered structure of volunteer service of college students determines that higher educational institutions should establish a unified evaluation and testing system to include it in the framework of course credits, employment target and quality education. The volunteer organizations are supposed to cultivate its relationship with volunteers to expand the diversification of volunteer activities by equal communication and deep involvement, which stimulates the passion of volunteers by meeting their internal

  9. Acceptability of early infant male circumcision among chinese parents: strategy implications of HIV prevention for china

    Directory of Open Access Journals (Sweden)

    Pan Lianjun

    2012-09-01

    Full Text Available Abstract Background Recent evidence has confirmed that circumcision can be performed as a preventive strategy for HIV and early infant male circumcision (EIMC is regarded to be safer than circumcision in adulthood; however, limited data are available in the literature about EIMC in China. Therefore, the present study was designed to determine the willingness and attitudes of Chinese parents on newborn male circumcision so as to provide data for exploring the feasibility of implementing EIMC as an HIV prevention strategy in China. Methods Simple random sampling was used to draw participants from parents who had a newborn son delivered at Nanjing Maternity and Child Health Care Hospital, which is affiliated to Nanjing Medical University, between March and December 2010. A questionnaire was used to determine general medical knowledge or information about circumcision, attitudes about EIMC, and level of decision-making on circumcision for the newborn son. Results Data derived from 558 responses were analyzed and the ratio of respondents was 56.3% for fathers and 43.6% for mothers. Of the respondents, 34.4% agreed to circumcise their newborn son, and the level of agreement was 3.25 ± 1.17 (range, 1–5 with “1” being “reluctantly agree” and “5” being “very strongly agree”. The major reason for EIMC was for health (44.8%, followed by doctor’s advice (31.2%. The major reason not to agree to EIMC was concern about pain (50.5%, followed by the risk of the procedure (23.5%. Conclusion The willingness and acceptability of EIMC in China is low and the parents of newborn sons are usually not very affirmative when making a decision on such a procedure, suggesting that significant effort will be needed if EIMC is to be implemented as an HIV prevention strategy for China.

  10. Whole body sodium MRI at 3T using an asymmetric birdcage resonator and short echo time sequence: first images of a male volunteer

    International Nuclear Information System (INIS)

    Sodium magnetic resonance imaging (23Na MRI) is a non-invasive technique which allows spatial resolution of the tissue sodium concentration (TSC) in the human body. TSC measurements could potentially serve to monitor early treatment success of chemotherapy on patients who suffer from whole body metastases. Yet, the acquisition of whole body sodium (23Na) images has been hampered so far by the lack of large resonators and the extremely low signal-to-noise ratio (SNR) achieved with existing resonator systems. In this study, a 23Na resonator was constructed for whole body 23Na MRI at 3T comprising of a 16-leg, asymmetrical birdcage structure with 34 cm height, 47.5 cm width and 50 cm length. The resonator was driven in quadrature mode and could be used either as a transceiver resonator or, since active decoupling was included, as a transmit-only resonator in conjunction with a receive-only (RO) surface resonator. The relative B1-field profile was simulated and measured on phantoms, and 3D whole body 23Na MRI data of a healthy male volunteer were acquired in five segments with a nominal isotropic resolution of (6 × 6 × 6) mm3 and a 10 min acquisition time per scan. The measured SNR values in the 23Na-MR images varied from 9 ± 2 in calf muscle, 15 ± 2 in brain tissue, 23 ± 2 in the prostate and up to 42 ± 5 in the vertebral discs. Arms, legs, knees and hands could also be resolved with applied resonator and short time-to-echo (TE) (0.5 ms) radial sequence. Up to fivefold SNR improvement was achieved through combining the birdcage with local RO surface coil. In conclusion, 23Na MRI of the entire human body provides sub-cm spatial resolution, which allows resolution of all major human body parts with a scan time of less than 60 min. (paper)

  11. Association between 5-hydroxytryptamine transporter gene-linked polymorphic region and smoking behavior in Chinese males

    Institute of Scientific and Technical Information of China (English)

    CHU Shui-lian; XIAO Dan; WANG Chen; JING Hang

    2009-01-01

    Background Tobacco use is the major risk factor for numerous health problems. However, only 5% of smokers can successfully quit without therapy owing to the highly addictive properties of nicotine. The serotoninergic system may be involved in smoking behavior because nicotine increases brain serotonin secretion, nicotine withdrawal decreases serotonin levels, and a selective serotonin reuptake inhibitor antagonizes the response to nicotine withdrawal. Serotonin transporter (5-HTT) is the most important protein, as it adjusts the serotonin concentration in the synaptic cleft. There is a polymorphism in the upstream regulatory region of the 5-HTT gene, named 5-hydroxytryptamine transporter gene-Iinked poyymorphic region (5-HTTLPR). Compared with the L allele, the S allele of the polymorphism is associated with decreased transcription efficiency of the 5-HTT gene. In this study, we investigated the relationship between this gene polymorphism and smoking behavior in Chinese males.Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed to find 5-HTTLPR gene polymorphisms in 144 smokers and 135 age-matched healthy non-smokers. A questionnaire was completed in all recruited subjects.Results The proportion of L/L (15.3% vs 5.2%) and S/L (50.0% vs 33.3%) genotypes was significantly higher in the smokers than that in the non-smokers (χ2=21.9; P <0.01). The odds ratio (OR) adjusted by age, education, effects of family members and friends who smoke, and alcohol intake was 2.9 (95%CI 1.78-4.80). In smokers, the number of cigarettes/day (L/L vs S/L vs S/S: 28+12 vs 20±8 vs 16±6, χ2=18.5, P <0.01), smoking index (L/L vs S/L vs S/S.. 561±446vs 393±341 vs 237+901, χ2=12.5, P <0.01) and score on the Fagerstrom test for nicotine dependence (FTND) (L/L vs S/L vs S/S. 7.8±1.6 vs 6.2±9.5 vs 3.5±9.1, χ2=48.3, P <0.01) were significantly higher in smokers with an L/L or S/L genotype than that in the smokers with the S/S genotype

  12. Relative bioequivalence evaluation of two oral atomoxetine hydrochloride capsules: a single dose, randomized, open-label, 2-period crossover study in healthy Chinese volunteers under fasting conditions.

    Science.gov (United States)

    Shang, D-W; Guo, W; Zhou, F-C; Wang, X-P; Li, A-N; Zhang, L; Li, W-B; Lu, W; Wang, C-Y

    2013-11-01

    To evaluate the bioequivalence of a new formulation of atomoxetine hydrochloride (CAS 82248-59-7) capsules (test) and an available branded capsules (reference) after administration of a single 40 mg dose, randomized, open-label, 2-period crossover study was conducted in 22 healthy male Chinese subjects with a 1-week wash-out period. This study was designed for/the Honglin Pharmaceutical Co. Ltd and contracted to be done by the Beijing Anding Hospital in order to satisfy Chinese regulatory requirements to allow marketing of this generic product and performed according to the criteria of SFDA. Blood samples were collected before and 0.25, 0.5, 1, 1.5, 2, 3, 4, 6, 9, 12, 16 and 24 h after drug administration. Plasma concentrations were determined by high-performance liquid chromatography (HPLC) with UV detection. A non-compartmental method was used to calculate the pharmacokinetic parameters and evaluate bioequivalence of the 2 formulations. The 90% confidence interval (CI) of the ratios (test/reference) of atomoxetine for AUC0-24, AUC0-∞ and Cmax were 100.9% (93.6-108.8%), 103.1% (95.1-111.7%) and 105.2% (92.8-119.4%), respectively, which fell within the interval of 80-125% and 75-133%. No clinically significant changes or abnormalities were noted in laboratory data and vital signs. From these results it can be concluded that the test formulation of atomoxetine capsules met the regulatory criterion for bioequivalence to the reference formulation. PMID:23812961

  13. Personality characteristics of Chinese male batterers: An exploratory study of women's reports from a refuge sample of battered women in Hong Kong

    OpenAIRE

    Brownridge, DA; Chan, EKL

    2008-01-01

    This study examined the personality characteristics of Chinese male batterers in a cohort of 210 Chinese battered women drawn from a refuge in Hong Kong. Participants were interviewed using a standard questionnaire to examine the prevalence and incidence of violence they experienced. The incidence of battering in the preceding year was compared against the characteristics of male batterers using independent t tests. Logistic regression was preformed with the personality characteristics and ba...

  14. Contribution of Myostatin gene polymorphisms to normal variation in lean mass, fat mass and peak BMD in Chinese male offspring

    Institute of Scientific and Technical Information of China (English)

    Hua YUE; Miao LI; Yu-juan LIU; Song-hua WU; Zhen-lin ZHANG; Jin-wei HE; Hao ZHANG; Chun WANG; Wei-wei HU; Jie-mei GU; Yao-hua KE; Wen-zhen FU; Yun-qiu HU

    2012-01-01

    Myostatin gene is a member of the transforming growth factor-β (TGF-β) family that negatively regulates skeletal muscle growth.Genetic polymorphisms in Myostatin were found to be associated with the peak bone mineral density (BMD) in Chinese women.The purpose of this study was to investigate whether Myostatin played a role in the normal variation in peak BMD,lean mass (LM),and fat mass (FM) of Chinese men.Methods:Four hundred male-offspring nuclear families of Chinese Han ethnic group were recruited.Anthropometric measurements,includingthe peak BMD,body LM and FM were measured using dual-energy X-ray absorptiometry (DXA).The single nucleotide polymorphisms (SNPs) studied were tag-SNPs selected by sequencing.Both rs2293284 and +2278G>A were genotyped using TaqMan assay,and rs3791783 was genotyped with PCR-restriction fragment length polymorphism (RFLP) analysis.The associations of the SNPs with anthropometfic variations were analyzed using the quantitative transmission disequilibrium test (QTDT).Results:Using QTDT to detect within-family associations,neither single SNP nor haplotype was found to be associated with peak BMD at any bone site.However,rs3791783 was found to be significantly associated with fat mass of the trunk (P<0.001).Moreover,for within-family associations,haplotypes AGG,AAA,and TGG were found to be significantly associated with the trunk fat mass (all P<0.001).Conclusion:Our results suggest that genetic variation within Myostatin may play a role in regulating the variation in fat mass in Chinese males.Additionally,the Myostatin gene may be a candidate that determines body fat mass in Chinese men.

  15. A Frequency Weighting Contour for Chinese Young Males%中国男性青年坐姿Z轴振动频率计权曲线

    Institute of Scientific and Technical Information of China (English)

    彭绍平; 李盈忠; 韩宜保; 肖艳华

    2000-01-01

    目的获取中国男性青年坐姿Z轴振动的频率计权曲线.方法被试者为10名男性青年,身体健康.实验采用对偶法.标准激励为频率8 Hz、加速度1.0 m/s2的正弦振动,实验激励也是正弦振动,频率为4~80 Hz,共14种.被试者自然放松地坐在实验座椅上,座椅刚性地固定在振动台面上.被试者首先承受标准激励,获得一个振动感觉,然后承受实验激励,用信号调节与切换装置调节其强度,直到获得与标准激励相同的振动感觉为止.再用振动信号记录系统记录此时实验激励的振动加速度的均方根值.将记录的数据利用最小二乘和优化设计的方法拟合成振动频率计权曲线.结果所得到的振动频率计权在16~80 Hz显著地大于ISO 2631-1相应的频率计权(P<0.005),在其它频率上则无显著差异. 结论坐姿中国男性青年对16~80 Hz的Z轴振动比ISO 2631-1规定的更敏感.%Objective To obtain the frequency weighting contour for seated Chinese young males in z axis.Method 10 male volunteers served as the subjects.They were exposed to standard vibration stimulus (a sinusoidal vibration of 1.0 m/s2 at 8 Hz) and 14 kinds of sinusoidal experimental vibration stimuli at frequencies from 4 Hz to 80 Hz.The magnitude of the experimental vibration stimulus was changed by the subject through a signal condition and switching device made by ourselves to obtain an equal vibration sensation to the standard vibration.The data were fitted to the same form of the frequency weighting Wk of ISO 2631-1 with the least square method and optimization of parameters.Result Compared with ISO 2631-1,the frequencies weightings of Chinese young males at 16~80 Hz are significantly higher than those of ISO 2631-1(P<0.005),but there are no significant difference between two frequency weighting contours at other frequencies. Conclusion Chinese young males are more sensitive to vibration at 16~80 Hz in Z axis.

  16. Cigarette smoking in male patients with chronic schizophrenia in a Chinese population: prevalence and relationship to clinical phenotypes.

    Directory of Open Access Journals (Sweden)

    Xiang Yang Zhang

    Full Text Available The high prevalence of smoking in schizophrenia of European background may be related to smoking's reducing clinical symptoms and medication side effects. Because smoking prevalence and its associations with clinical phenotypes are less well characterized in Chinese than European patients with schizophrenia, we assessed these smoking behaviors using clinician-administered questionnaires and the Fagerstrom Test for Nicotine Dependence (FTND in 776 Chinese male schizophrenia and 560 control subjects. Patients also were rated on the Positive and Negative Symptom Scale (PANSS, the Simpson and Angus Extrapyramidal Symptom Rating Scale (SAES, and the Abnormal Involuntary Movement Scale (AIMS. We found that the schizophrenia patients had a higher lifetime incidence of smoking (79% vs 63%, were more likely to be heavy smokers (61% vs 31%, and had lower smoking cessation rates (4% vs 9% (all p0.05 than the non-smoking patients. These results suggest that Chinese males with schizophrenia smoke more frequently than the general population. Further, smokers with schizophrenia may display fewer negative symptoms and possibly less parkinsonism than non-smokers with schizophrenia.

  17. Pharmacokinetics of oxatomide tablets in healthy Chinese volunteers%奥沙米特片健康人体药代动力学

    Institute of Scientific and Technical Information of China (English)

    吴黎莉; 陈法; 徐兰芳; 隗慧林

    2011-01-01

    The pharmacokinetics of oxatomide tablets in healthy Chinese volunteers after single and multiple-dose oral administration and the effect of food on it were studied. Single-dose study was carried out according to a replicated 3×3 Latin square design, with 12 volunteers orally receiving test tablets in single dose of 30 mg, 60 mg and 120 mg, respectively. Blood samples were collected at specified time intervals up to 48 hours. The washout interval was 1 week. Multiple-dose study was carried out according to a 1-period design. Each volunteer orally received 30 mg oxatomide tablet twice daily (at 7:00 and 19: 00) until the morning of the 7 th day. Venous blood (4. 0 mL) was drawn at the 5th and 6th mornings before administration to make sure that the steady state has appeared. On the 7th day, blood samples were collected again following the pre-specified time points after the last dose up to 48 h. After a washout period of 1 week, food effect was studied out according to an open, randomized, 2-period crossover design. Oxatomide tablets (30 mg) were administered in fasting or eating state. The washout period was 1 week. Blood samples were collected at specified time intervals up to 48 hours. The plasma concentra-tion-curves of oxatomide in this pharmacokinetic study were determined by a validated HPLC-MS method. The main pharmacokinetic parameters were calculated by software DAS 2. 0. The validated method was proved to be simple, sensitive and rapid. The results exhibited that the absorption and disposition of oxatomide in human body followed the first order kinetics. There was no statistically significant difference between the phamacokinetic parameters of multiple- and single-dose study, which demonstrated that there was basically no accumulation of oxatomide in multiple-dose study. Food would affect the absorption rate of oxatomide, but not the extent of its absorption.%研究健康志愿者单次及多次口服奥沙米特片的药代动力学特征,并考察食

  18. Association of ALOX15 gene polymorphisms with obesity-related phenotypes in Chinese nuclear families with male offspring

    Institute of Scientific and Technical Information of China (English)

    Yao-hua KE; Chun WANG; Yun-qiu HU; Miao LI; Yu-juan LIU; Wen-zhen FU; Zhen-lin ZHANG; Wen-jin XIAO; Jin-wei HE; Hao ZHANG; Jin-bo YU; Wei-wei HU; Jie-mei GU; Gao GAO; Hua YUE

    2012-01-01

    Aim:Genetic variation in ALOX12,which encoded human 12-lipoxygenase,was found to be associated with fat mass in young Chinese men.The objective of this study was to investigate the relationship between single nucleotide polymorphisms (SNPs) and haplotypes in the ALOX15 gene and obesity-related phenotypes in Chinese nuclear families with male offspring.Methods:We recruited 1,296 subjects from 427 nuclear families with male offspring and genotyped five SNPs (rs9894225,rs748694,rs2619112,rs2619118,and rs916055) in the ALOX15 gene locus.The total fat mass (TFM),trunk fat mass (tFM),leg fat mass (LFM) and arm fat mass (AFM) were measured using dual-energy X-ray absorptiometry (DXA).The percentage of fat mass (PFM) was the ratio of TFM and body weight.The association between SNPs and haplotypes of ALOX15 and obesity-related phenotypic variation was measured using quantitative transmission disequilibrium test (QTDT).Results:Using QTDT to measure family-based genetic association,we found that rs916055 had a statistically significant association with PFM (P=0.038),whereas rs916055 had a marginal but statistically insignificant association with tFM (P=0.093).The multipleparameter 1000 permutations test agreed with the family-based association results:both showed that rs916055 had a statistically significant association with PFM (P=0.033).Conclusion:rs916055 in ALOX15 gene was significantly associated with the percentage of fat mass in Chinese nuclear families with male offspring in the family-based association study using QTDT approach.

  19. 国产盐酸托莫西汀胶囊在健康人体的生物等效性%Bioequivalence of atomoxetine hydrochloride in Chinese health volunteers

    Institute of Scientific and Technical Information of China (English)

    魏计超; 刘西哲; 于洋; 侯艳宁

    2015-01-01

    Objective To establish a method for determination of atomoxetine plasma concentration by HPLC-MS/MS and study the bioavailability and bioequivalence of atomoxetine capsule in Chinese health male volunteers. Methods A randomized,two periods,crossover bioequivalence trial was designed. 24 healthy volunteers were randomly divided into two groups,and they were given a single oral dose of the tested atomoxetine capsule and reference atomoxetine capsule 20mg re-spectively. The concentrations of atomoxetine in plasma were determined by a valid LC-MS/ MS method. The pharmacokinetic parameters and relative bioavailability were processed by DAS 2. 1. 1 program to evaluate the bioequivalence of test and refer-ence capsule. Results The pharmacokinetic parameters of the test and reference capsules were as follows:Cmax were(232. 5 ± 86. 9)and(222. 8 ± 101. 1)ng/ ml;tmax were(1. 17 ± 1. 14)and(1. 27 ± 1. 09)h;t1 / 2 were(3. 55 ± 1. 33)and(3. 38 ± 1. 20)h;AUC0 - t were(1610 ± 1329)and(1575 ± 1301)ng·ml - 1 ·h - 1;AUC0 - ∞ were(1683 ± 1466)and(1634 ± 1392)ng·ml - 1 ·h - 1 ,respectively. The relative bioavailability of the test capsules was(104. 9 ± 14. 3)% . Conclusion The two preparations were bioequivalence.%目的:建立人血浆中托莫西汀浓度的 HPLC-MS/ MS 测定方法,研究国产盐酸托莫西汀胶囊在中国健康男性志愿者的主要药动学参数及与参比制剂的生物等效性。方法采用两试剂双周期交叉试验设计,24名健康受试者分别单剂量口服受试制剂和参比制剂20mg,采用 LC-MS/ MS 法测定血浆中托莫西汀的浓度,DAS 2.1.1软件计算药动学参数并考察生物等效性。结果受试制剂和参比制剂在受试者体内的药动学参数如下:Cmax 分别为(232.5±86.9)和(222.8±101.1)ng/ ml;tmax 分别为(1.17±1.14)和(1.27±1.09)h;t1/2分别为(3.55±1.33)和(3.38±1.2)h;AUC0- t分别为(1610±1329)和(1575±1301)ng·ml -1·h -1;AUC0

  20. Study on Bioequivalence of Cefdinir Capsules in Chinese Healthy Volunteers%头孢地尼胶囊在健康人体的生物等效性研究

    Institute of Scientific and Technical Information of China (English)

    陈芬; 朱超然; 翟学佳; 冯霞; 邓桂萍; 郭卿; 蒋立芬; 吕永宁

    2015-01-01

    目的:评价健康人餐后服用两种头孢地尼胶囊的生物等效性。方法24例男性健康志愿者餐后随机交叉单剂量口服头孢地尼胶囊受试制剂或参比制剂,头孢地尼体内血药浓度采用液相色谱-质谱串联( LC-MS/MS)法测定,药动学参数及等效性采用药动学软件DAS计算和评价。结果受试制剂和参比制剂的主要药动学参数如下:AUCt分别为(4.35±1.09)和(4.12±1.22)μg��h��mL-1,AUC0-∞分别为(4.53±1.12)和(4.53±1.73)μg��h��mL-1,t1/2分别为(1.74±0.29)和(2.13±1.65) h,tmax分别为(4.44±0.86)和(4.54±1.16) h,Cmax分别为(900±250)和(876±269) ng��mL-1。结论头孢地尼胶囊受试制剂与参比制剂具有生物等效性。%Objective To evaluate postprandial pharmacokinetics and bioequivalence of two preparations of cefdinir capsules in Chinese healthy volunteers. Methods In a two-way cross-over study, 24 healthy male volunteers were divided into two groups randomly and a single dose of cefdinir capsules of test and reference preparation were administered orally, respectively.The concentration in plasma was determined by LC-MS/MS. Pharmacokinetic parameters and bioequivalence were calculated and evaluated by DAS. Results The main pharmacokinetic parameters of test and reference were as follows: AUCt (4.35±1.09) μg��h��mL-1 and (4.12±1.22) μg��h��mL-1, AUC0-∞(4.53±1.12) and (4.53±1.73) μg��h��mL-1, t1/2 (1.74±0.29) h and (2.13±1.65) h, tmax(4.44±0.86) h and (4.54 ±1.16) h, Cmax(900±250) ng��mL-1 and (876±269) ng��mL-1 . Conclusion The test and reference preparation of cefdinir capsules are bioequivalent.

  1. 更昔洛韦分散片和胶囊在健康人体中的生物等效性%Bioequivalence of ganciclovir dispersible tablets and capsules in Chinese healthy volunteers

    Institute of Scientific and Technical Information of China (English)

    刘茜; 邓琳琳; 赵辉; 张旭; 刘洋

    2011-01-01

    目的 研究更昔洛韦分散片和胶囊在人体内的生物等效性.方法 采用双交叉随机自身对照试验设计,20名健康受试者分别单剂量口服更昔洛韦胶囊和分散片1 000 mg后,采用HPLC法测定血药浓度,DAS2.0软件计算药动学参数,并进行等效性检验.结果 更昔洛韦分散片和胶囊的主要药动学参数:pmax分别为(0.58±0.18)和(0.60±0.20)mg·L-1,Tmax分别为(3.0±0.4)和(3.2±0.4)h,t1/2分别为(4.6±1.3)和(4.6±0.8)h,AUC0-t分别为(2.8±0.8)和(3.2±1.2)mg·h·L-1,更昔洛韦分散片和胶囊的平均相对生物利用度为(96±28)%.结论 更昔洛韦分散片和胶囊在人体内生物等效.%AIM To evaluate the bioequivalence of ganciclovir dispersible tablets and capsules in Chinese healthy volunteers.METHODS In a randomized, crossover and self-controlled study, 20 male healthy volunteers were administered with a single oral dose of test and reference preparations containing 1 000 mg ganciclovir, respectively.The plasma concentrations of ganciclovir were determined by HPLC-UV.The pharmacokinetic parameters were calculated and the bioequivalence of the two preparations was evaluated by DAS software 2.0.RESULTS The main pharmacokinetic parameters of the ganciclovir dispersible tablets and capsules were as follows: pmax were (0.58 ± 0.18) and (0.60 ± 0.20) mg·L-1, τmax were (3.0 ± 0.4) and (3.2 ± 0.4) h, t1/2 were (4.6 ± 1.3) and (4.6 ± 0.8) h, AUC0-t were (2.8 ± 0.8) and (3.2 ± 1.2) mg·h·L-1.The relative bioavailability of ganciclovir dispersible tablets was (96 ± 28) %.CONCLUSION Ganciclovir dispersible tablets and capsules are bioequivalent.

  2. Pharmacokinetics and Bioequivalence of Domestic Olanzapine Tablets in Healthy Chinese Volunteers%国产奥氮平片的人体药动学和生物等效性研究

    Institute of Scientific and Technical Information of China (English)

    俞凌燕; 楼洪刚; 阮邹荣; 江波; 陈金亮

    2012-01-01

    目的 评价国产奥氮平片在中国健康人体中的药动学及生物等效性.方法 采用双周期交叉试验设计,20名健康男性受试者单次口服国产和进口奥氮平片5 mg,采用LC-MS/MS测定奥氮平血药浓度,计算两制剂的主要药动学参数和生物利用度,并进行生物等效性评价.结果 国产和进口奥氮平片的主要药动学参数如下:tmax分别为(4.25±1.33)和(4.55±1.10)h,ρmax分别为(9.62±1.79)和(9.69±2.18)ng·mL-1,t1/2分别为(31.71±6.87)和(32.46±5.67)h,AUC0-t分别为(327.19±60.55)和(324.39±70.84)ng·h·mL-1,AUC0-∞分别为(354.44±74.58)和(350.70±80.94)ng·h·mL-1.受试制剂的相对生物利用度F0-t为(102.93±18.22)%,F0-∞为(103.30±20.75)%,经统计分析,各药动学参数均无显著性差异(P>0.05)结论 两种奥氮平制剂在体内过程相似,两制剂人体生物等效,临床上可以替换使用.%OBJECTIVE To study the pharmacokinetics and bioequivalence of domestic olanzapine tablets in healthy Chinese volunteers. METHODS A single oral dose of 5 mg olanzapine tablets was given to 20 healthy male volunteers in a randomized cross-over study. The concentrations of olanzapine in plasma were determined by LC-MS/MS method. The pharmacokinetie parameters and relative bioavailability were calculated by DAS. Then the bioequivalence of two formulations was evaluated. RESULTS The pharmacokinetie parameters of domestic and imported formulations were as follows ;tmax (4. 25 ±1.33) and (4.55 ± 1. 10) h, pmax(9.62 ± 1.79) and (9. 69 ±2. 18) ng·mL-1, t1/2 (31.71 ±6.87) and (32.46+5.67) h, AUC0-t, ( 327. 19 ± 60. 55 ) and (324. 39 ± 70. 84) ng·h·mL-1 , and AUC 0-∞ (354.44 ±74. 58) and (350. 70 ± 80. 94) ng·h·ml-1 , respectively. The relative bioavailability was ( 102. 93 ±18. 22 ) % for F0-t and ( 103. 30 ± 20. 75 ) % for F0-x. There was no significant difference between the two preparations (P >0. 05). CONCLUSION The two preparations are bioequivalent and can

  3. Association analysis of GABA receptor subunit genes on 5q33 with heroin dependence in a Chinese male population.

    Science.gov (United States)

    Loh, E W; Tang, N L S; Lee, D T S; Liu, S I; Stadlin, Alfreda

    2007-06-01

    GABAA receptor subunit genes clustered on 5q33 play a role in the development of alcoholism and methamphetamine use disorder without psychosis. The present study explored the possible contribution of the same subunit genes to the development of heroin dependence. Single nucleotide polymorphisms (SNPs) of the GABAA receptor subunits GABRB2, GABRA6, GABRA1, and GABRG2 were examined in 178 male Han Chinese heroin-dependent and 170 male control subjects. A significant difference in allele frequency for the SNP rs211014 in the GABAAgamma2 receptor subunit gene between cases and controls was identified (P = 0.015). A possible mechanism for the involvement of the GABA receptor subunit genes on 5q33 in the development of heroin dependence is discussed. PMID:17440936

  4. Genetic variation in BCL2 3'-UTR was associated with lung cancer risk and prognosis in male Chinese population.

    Directory of Open Access Journals (Sweden)

    Ping Xu

    Full Text Available OBJECTIVES: Bcl-2 is a critical apoptosis inhibitor with established carcinogenic potential, and can confer cancer cell resistance to therapeutic treatments by activating anti-apoptotic cellular defense. We hypothesized that genetic variants of BCL2 gene may be associated with lung cancer susceptibility and prognosis. METHODS: Three selected tagSNPs of BCL2 (rs2279115, rs1801018, and rs1564483 were genotyped in 1017 paired male Chinese lung cancer cases and controls by TaqMan assay. The associations of these variants with risk of lung cancer and overall survival of 242 male advanced non-small-cell lung cancer (NSCLC patients were separately investigated. RESULTS: Compared with the BCL2 3'UTR rs1564483GG genotype, the rs1564483GA, AA, and GA+AA genotypes were associated with significantly decreased susceptibilities of lung cancer in male Chinese (adjusted OR = 0.78, 0.73, and 0.76, P = 0.016, 0.038, and 0.007, respectively, while rs1564483A allele has a inverse dose-response relationship with lung cancer risk (P trend = 0.010. These effects were more evident in the elders, smokers, and subjects without family history of cancer (P trend = 0.017, 0.043 and 0.005, respectively. Furthermore, advanced NSCLC males carrying BCL2 rs1564483 GA+AA genotypes had significantly longer median survival time (Long-rank P = 0.036 and decreased death risk (adjusted HR = 0.69, P = 0.027 than patients with rs1564483GG genotype. These effects were more obvious in patients with smoking, stage IIIA, and in patients without surgery but underwent chemotherapy or radiotherapy (adjusted HR = 0.68, 0.49, 0.67, 0.69, 0.50, respectively, all P<0.05. CONCLUSION: The BCL2 3'UTR rs1564483A allele was associated with a decreased lung cancer risk and better survival for advanced NSCLC in male Chinese, which may offer a novel biomarker for identifying high-risk population and predicting clinical outcomes.

  5. 单剂量静滴头孢吡肟在中国五个民族人群中的药动学%Pharmacokinetcs of Single Dose Cefepime Injection in Chinese Han,Mongolia,Korean,Uigur,and Hui Healthy Volunteers

    Institute of Scientific and Technical Information of China (English)

    郭涛; 夏东亚; 段威; 赵龙山; 曾平; 肖勇; 赵东祥; 杨长青; 白音

    2012-01-01

    and compare the pharmacokinetics of cefepime in healthy volunteers of different Chinese nationalities (Han,Mongolia,Uigur,Korea,and Hui) and different genders,thus to provide instruction and help for using cefepime safely,rationaly and effectively in both ordinary clinic and remedy of battle wound. METHODS A single dose of 1. 0 g cefepime was given by intravenous infusion under fasting condition to ten healthy volunteers (five males and five females) of each Chinese nationality. Plasma samples were obtained before dosing and at various predetermined time points after the dosing,and the plasma concentrations were determined by a validated HPLC-UV method. The pharmacokinetic parameters were calculated by DAS2.0 software and were compared by SPSS11.5 software. RESULTS The PK parameters of cefepime in Han,Mongolia,Uigur,Korea and Hui nationalities after a single intravenous administration of 1.0 g were as follows · t1/2β (1. 97 ± 0. 20),(2. 10 ± 0. 33),(2.06 ± 0. 33),(2.40 ±0.65),and(1.94 ±0. 24) h; AUC0-∞ (139.69 ± 23. 78 ),( 153.92 ± 22.79),(165.58 ±24.49),(142.11 ±29.77),and (132.78 ±23. 79) mg · h · L-1 ;ρmax(68.75 ± 10.41) ,(78.22 ±13.87) ,(83.19 ± 10. 31) ,(73. 82 ±9.59),and(62.91 ±10.09) mg · L-1,respectively. The PK parameters of cefepime in 25 male volunteers and 25 female volunteers after a single intravenous administration of 1.0 g were as follows: t1/2β(2. 06 ±0.54)and(2. 13 ±0.44)h; AUC0-∞ (134. 06 ±22. 33)and( 158. 68 ±24. 85)mg · h· L-1;ρmax(66.94±9. 14)and(78.95±12.71)mg · L-1 respectively. Results of ANOVA and Kruskal-Wallis rank test showed that there were no significant differences in the PK parameters Vd,CL,InAUC,and t1/2β of different nationalities and in Vd and t1/2β of different genders,but there were significant differences in lnρmax of different nationalities and CL,InAUC,and lnρmaxof dif-ferent genders. Then,it was found there was high linear correlation( P <0. 01 ) between body weight and CL,InAUC and In

  6. Student Volunteering in China and Canada:Comparative Perspectives

    Directory of Open Access Journals (Sweden)

    Lesley Hustinx

    2012-01-01

    Full Text Available While many of the theoretical frameworks for volunteering have beendeveloped and empirically tested in the West, our understanding of volunteering in non-Western countries, such as China, is relatively limited. Nevertheless, in recent decades enormous efforts have been made by the Chinese government to encourage and support volunteering among its citizens, especially youth. Chinese youth are volunteering in greater numbers in response to these initiatives. Given the strongly state-led nature of volunteering in China, as opposed to the voluntary, more citizen-initiated nature of volunteering in Western societies, this paper seeks to understand the impact of these contextual differences on student volunteering. Using data from 1,892 questionnaires completed by university students in China and Canada, we examine differences in their volunteering. The findings clearly show the impact of the differences in sociopolitical structures that are reflected in the nature of students’ volunteer participation and perceived benefits.

  7. Male reproductive health research needs and research agenda: Asian and Chinese perspective

    Institute of Scientific and Technical Information of China (English)

    Yi-FeiWANG

    1999-01-01

    Research that addresses male re-productive health should assist in the development of reproductive health programmaes and policy; identify and test new leads in nude contraceptive technology; establish effective male involvement initiatives which are likely to have a positive impact on the reproductive health of men and women; guide the allocation of health care reources to ensure cost-effectiveness of interventions; generate new knowledge, develop diagnustic technology in reproductive health and offer optimal treatment/care regimens. In considering the needs and demands of nude reproductive health research in Asia and the Pacific, the following six research topics are recommended as the priority research areas: male contraceptive technology; nude reproductive health behaviour and male adolescent reproductive health; male reproductive aging including male menopause and other diseases; male RTIs, STDs, HIV/AIDS; prevalence, management and prevention of nude infertility; environment and semen quality and other male reproductive problems. One of the major challenges now facing us is the elaburation of a comprehensive, yet realistic male reproductive health research agenda that reflect the needs and demands of Asian developing countries. To this end, to make use of an interdisciplinary approach is of strategic importance. The most creative insights and productive leads are likely to emerge from a research team that is inteldisciplinary especially in the field of reproductive health. ( Asian J Androl 1999 Jun; 1: 13-20)

  8. Cutural Predictors of Self-Esteem: A Study of Chinese American Female and Male Young Adults.

    Science.gov (United States)

    Tsai, Jeanne L.; Ying, Yu-Wen; Lee, Peter Allen

    2001-01-01

    Domains of cultural orientation such as language, social affiliation, and cultural pride, were examined in Chinese American college students (N=353) to see how they related to self-esteem. Cultural orientation significantly predicted self-esteem differences. Cultural predictors of self-esteem varied by gender; self-esteem was mainly related to…

  9. Construction of Chinese adult male phantom library and its application in the virtual calibration of in vivo measurement

    Science.gov (United States)

    Chen, Yizheng; Qiu, Rui; Li, Chunyan; Wu, Zhen; Li, Junli

    2016-03-01

    In vivo measurement is a main method of internal contamination evaluation, particularly for large numbers of people after a nuclear accident. Before the practical application, it is necessary to obtain the counting efficiency of the detector by calibration. The virtual calibration based on Monte Carlo simulation usually uses the reference human computational phantom, and the morphological difference between the monitored personnel with the calibrated phantom may lead to the deviation of the counting efficiency. Therefore, a phantom library containing a wide range of heights and total body masses is needed. In this study, a Chinese reference adult male polygon surface (CRAM_S) phantom was constructed based on the CRAM voxel phantom, with the organ models adjusted to match the Chinese reference data. CRAMS phantom was then transformed to sitting posture for convenience in practical monitoring. Referring to the mass and height distribution of the Chinese adult male, a phantom library containing 84 phantoms was constructed by deforming the reference surface phantom. Phantoms in the library have 7 different heights ranging from 155 cm to 185 cm, and there are 12 phantoms with different total body masses in each height. As an example of application, organ specific and total counting efficiencies of Ba-133 were calculated using the MCNPX code, with two series of phantoms selected from the library. The influence of morphological variation on the counting efficiency was analyzed. The results show only using the reference phantom in virtual calibration may lead to an error of 68.9% for total counting efficiency. Thus the influence of morphological difference on virtual calibration can be greatly reduced using the phantom library with a wide range of masses and heights instead of a single reference phantom.

  10. Polymorphisms of angiotensin-converting enzyme 2 gene confer a risk to lone atrial fibrillation in Chinese male patients

    Institute of Scientific and Technical Information of China (English)

    WANG Shu-xia; TAO Tao; FU Zhi-qing; XIE Xiang-zhu; WANG Hao; WANG Yu-tang

    2013-01-01

    Background Growing epidemiologic evidence has indicated that genetics can predispose individuals to the occurrence of lone atrial fibrillation (AF).The angiotensin-converting enzyme 2 (ACE2) gene has been established to be associated with hypertension and left ventricular hypertrophy.The objective of our study was to investigate the association of ACE2 gene polymorphisms with lone AF.Methods A total of 265 consecutive lone AF patients and 289 healthy controls were successfully investigated.The polymorphisms rs2106809 and rs2285666 were genotyped by polymerase chain reaction (PCR) and direct sequencing.A Logistic regression model was used to determine the odds ratio (OR) and 95% confidence intervals (CI) of variations of ACE2 for lone AF.Results The T allele of rs2106809 conferred an increased risk for lone AF (OR 1.24,95% CI 1.01-1.52,P=0.03) in males after adjustment for conventional risk factors.SNP at rs2285666 in males was not significantly different between AF patients and controls.No association was found between the two polymorphisms in the female population with lone AF.After (36.3±4.5) months of follow-up,the end point data were obtained:death (cardiac and noncardiac),ischemic stroke,and heart failure.In the male subgroup,the associations between rs2106809 T male carriers and combined end points including ischemic stroke,heart failure,and death in our study were of significance (OR 3.6,95% CI 1.0-13.1,P=0.04).Conclusions The results indicate that polymorphism at ACE2 gene is associated with male lone AF in a Chinese Han population.Lone AF males who carry the rs2106809 T allele are associated with adverse cardiac events.

  11. Voices from a minority: experiences of chinese male nursing students in clinical practice.

    Science.gov (United States)

    Chan, Z C Y; Lui, C W; Cheung, K L; Hung, K K; Yu, K H; Kei, S H

    2013-07-01

    In Hong Kong, males constituted only about 10.2% of the nursing workforce in 2010. The learning experiences of male nursing students in Hong Kong during their clinical practicum have rarely been explored. If these students cannot maintain their psychological well-being and psychological health in formal education and clinical placements, then their physical health will also suffer. This ethnographic qualitative study gave male nursing students in Hong Kong a chance to voice their experiences during their clinical practicum. Selected through snowball sampling, 18 male nursing students from a local university participated in individual face-to-face semistructured interviews. The data were processed with content analysis. The findings indicated that male students not only received more support and understanding from male rather than female members of staff but endured a certain amount of oppression while working in female wards. According to the students' comments on nursing culture, the work climate of male nursing students could be improved by reorganizing the clinical placements and providing extra support to male nursing students. PMID:23339129

  12. Relationship of carotid intima-media thickness and duration of vegetarian diet in Chinese male vegetarians

    OpenAIRE

    Liu Chang-Qin; Yan Bing; Wang Li-Ying; Sun Su-Yun; Zhang Hui-Jie; Yang Shu-Yu; Zhang Wei; Li Xue-Jun

    2011-01-01

    Abstract Objective Many studies have shown that vegetarian diet has beneficial effects on the prevention of cardiovascular diseases. However, the effect of vegetarian diet on carotid intima-media thickness (IMT), as well as the association between IMT and duration of vegetarian diet, are still unclear. The present study aims to investigate the influence of duration of vegetarian diet on cardiovascular risk factors, and more importantly on IMT among Chinese vegetarians. Methods One hundred and...

  13. Dose conversion coefficients for Chinese reference adult male and female voxel phantoms from idealized neutron exposures

    CERN Document Server

    Liu, Huan; Qiu, Rui; Yang, Yue; Pan, Yu-Xi; Liu, Li-Ye

    2015-01-01

    A new set of fluence-to-dose conversion coefficients based on the Chinese reference adult voxel phantoms CRAM and CRAF are presented for six idealized external neutron exposures from 10-8 MeV to 20 MeV. The voxel phantoms CRAM and CRAF were adjusted from the previous phantoms CNMAN and CNWM respectively, and the masses of individual organs have been adjusted to the Chinese reference data. The calculation of organ-absorbed doses and effective doses were performed with the Monte Carlo transport code MCNPX. The resulting dose conversion coefficients were compared with those published in ICRP Publication 116, which represents the reference Caucasian. The organ-absorbed dose conversion coefficients of most organs are in good agreement with the results in ICRP Publication 116, however, obvious discrepancies are observed for some organs and certain geometries. For neutrons with energies above 2 MeV, the effective dose conversion coefficients of Chinese reference adult are almost identical to those of ICRP Publicatio...

  14. 硫酸氢氯吡格雷片的人体生物等效性%The bioequivalence of clopidogrel hydrogen sulfate tablets in Chinese healthy volunteers

    Institute of Scientific and Technical Information of China (English)

    舒成仁; 卫乐乐; 黄露; 黎维勇

    2012-01-01

    OBJECTIVE To study the bioequivalence of clopidogrel hydrogen sulfate tablets. METHODS 30 healthy male volunteers were administered 150 mg clopidogrel hydrogen shlfate tablets orally in a randomized crossover design. The drug concentrations in the plasma samples were determined by an HPLC-MS/MS method. With use of DAS software the pharmaco-kinetic parameters were calculated and the bioequivalence of the two preparations was evaluated. RESULTS The main pharma-cokinetic parameters of the test and reference preparations were as follows;/?, were(0. 98 ± 0. 34) h and(0. 86 ± 0. 36) h;Cmax were(8 994. 7 + 3 515. 6) ng·mL-1 and(9 677. 0±3 838. 1) ng·mL-1 ;t1/t2 were(7. ()± 2. 4) h and(7. 0+1. 8) h; AUG41-24 were (31 670. 1 ± 13 545. 7) ng·h·mL-1 and(32 887. 4 ± 14 907. 5) ng·h·mL-1; AUG were(34 096. 8 + 14 482. 3) ng·h·mL-1 and(35 550. 4+16 455.5) ng·h·mL-1. The relative bioavailability of the test tablet was(97. 7 + 16. 6)%. CONCLUSION The two preparations are bioequivalent.%目的:研究硫酸氢氯吡格雷片受试制剂与参比制剂的人体生物等效性.方法:30名健康男性志愿者随机交叉单剂量口服硫酸氢氯吡格雷试验片或对照片1 50 mg,采用高效液相色谱-串联质谱(HPLC-MS/MS)法测定血浆中氯吡格雷羧酸代谢产物浓度.用DAS软件计算两者的药动学参数,并评价其生物等效性.结果:受试制剂与参比制剂的tmax分别为(0.98±0.34)、(0.86±0.36) h;Cmax分别为(8 994.7±3 515.6)、(9 677.0±3 838.1)ng·mL-1;t1/2分别为(7.0±2.4)、(7.0±1.8)h;AUG0-24分别为(31 670.1±13 545.7)、(32 887.4±14 907.5)ng·h·mL-1;AUG0→∞分别为(34 096.8±14 482.3)、(35 550.4±16 455.5)ng·h·mL-1.受试制剂的相对生物利用度为(97.7±16.6)%.结论:2种制剂具有生物等效性.

  15. GEANT4 calculations of neutron dose in radiation protection using a homogeneous phantom and a Chinese hybrid male phantom.

    Science.gov (United States)

    Geng, Changran; Tang, Xiaobin; Guan, Fada; Johns, Jesse; Vasudevan, Latha; Gong, Chunhui; Shu, Diyun; Chen, Da

    2016-03-01

    The purpose of this study is to verify the feasibility of applying GEANT4 (version 10.01) in neutron dose calculations in radiation protection by comparing the calculation results with MCNP5. The depth dose distributions are investigated in a homogeneous phantom, and the fluence-to-dose conversion coefficients are calculated for different organs in the Chinese hybrid male phantom for neutrons with energy ranging from 1 × 10(-9) to 10 MeV. By comparing the simulation results between GEANT4 and MCNP5, it is shown that using the high-precision (HP) neutron physics list, GEANT4 produces the closest simulation results to MCNP5. However, differences could be observed when the neutron energy is lower than 1 × 10(-6) MeV. Activating the thermal scattering with an S matrix correction in GEANT4 with HP and MCNP5 in thermal energy range can reduce the difference between these two codes. PMID:26156875

  16. GEANT4 calculations of neutron dose in radiation protection using a homogeneous phantom and a Chinese hybrid male phantom

    International Nuclear Information System (INIS)

    The purpose of this study is to verify the feasibility of applying GEANT4 (version 10.01) in neutron dose calculations in radiation protection by comparing the calculation results with MCNP5. The depth dose distributions are investigated in a homogeneous phantom, and the fluence-to-dose conversion coefficients are calculated for different organs in the Chinese hybrid male phantom for neutrons with energy ranging from 1 x 10-9 to 10 MeV. By comparing the simulation results between GEANT4 and MCNP5, it is shown that using the high-precision (HP) neutron physics list, GEANT4 produces the closest simulation results to MCNP5. However, differences could be observed when the neutron energy is lower than 1 x 10-6 MeV. Activating the thermal scattering with an S matrix correction in GEANT4 with HP and MCNP5 in thermal energy range can reduce the difference between these two codes. (authors)

  17. An overview of male reproductive studies of boron with an emphasis on studies of highly exposed Chinese workers

    DEFF Research Database (Denmark)

    Scialli, Anthony R; Bonde, Jens Peter; Brüske-Hohlfeld, Irene; Culver, B Dwight; Li, Yanhong; Sullivan, Frank M

    2010-01-01

    Boron treatment of rats, mice, and dogs has been associated with testicular toxicity, characterized by inhibited spermiation at lower dose levels and a reduction in epididymal sperm count at higher dose levels. The no-adverse-effect level for reproductive effects in male rats is 17.5mg B/kg bw...... working in boron (B) mining or processing in Liaoning province in northeast China has been published in several Chinese and a few English language papers. This study included individual assessment of boron exposure, interview data on reproductive experience and semen analysis. Employed men living in the...... same community and in a remote community were used as controls. Boron workers (n=75) had a mean daily boron intake of 31.3mg B/day, and a subset of 16 of these men, employed at a plant where there was heavy boron contamination of the water supply, had an estimated mean daily boron intake of 125 mg B...

  18. Working Long Hours is Associated with Higher Prevalence of Diabetes in Urban Male Chinese Workers: The Rosai Karoshi Study.

    Science.gov (United States)

    Tayama, Jun; Li, Jue; Munakata, Masanori

    2016-02-01

    We investigated the relationship between number of weekly working hours and the prevalence of diabetes in the urban Chinese population. Data regarding anthropometric measurements, fasting blood glucose level and number of hours worked per week were collected from 2228 workers in Shanghai, China (Mage  = 44 years; 64% men). Participants were divided into three groups according to the number of hours worked per week (<45, 45-54 and ≥55), and multiple logistic regression analysis was conducted with diabetes as the dependent variable. Subjects with a HbA1c of 6.5% or above or those prescribed anti-diabetic medications were defined as having diabetes. The multivariate adjusted odds ratio for having diabetes was found to be significantly higher for those who worked ≥55 h per week compared with those who worked <45 h per week, but only for men. This finding indicates that working long hours could be a risk factor for diabetes in Chinese male workers. PMID:24789310

  19. Er-Xian Decoction, a traditional Chinese herbal formula, intervening early in hypothalamic-pituitary axis of male rats with delayed puberty

    OpenAIRE

    Zheng Zhu; LiHong Li; Xin Jin; JianWei Fang; DongFang Zhang

    2014-01-01

    Background: Er-Xian Decoction (EXD) is one of the traditional Chinese medicine (TCM) with unique effect on osteoporosis, menopausal syndrome and delayed puberty in China for many years. Objective: We aim to evaluate the potential activity of starting hypothalamic-pituitary-testicular (HPT) axis of male rats with delayed puberty. Materials and Methods : Delayed puberty model of male Sprague-Dawley (SD) rats were established with soy isoflavones (90 mg·kg -1 ) and were treated by EXD extract at...

  20. The tactical life model : reconfiguring the Chinese male body in performance and participatory art practice.

    OpenAIRE

    Ling, Yuen Fong

    2012-01-01

    This examination of recent art from China argues that the artist is increasingly returning the gaze, in which the seemingly problematic representation of the subservient body is a self-aware and nuanced presentation. Explored through the trials of a “British-Chinese” male artist’s tentative re-framing of his own body and its reproduction.

  1. Only male matrilineal relatives with Leber's hereditary optic neuropathy in a large Chinese family carrying the mitochondrial DNA G11778A mutation

    International Nuclear Information System (INIS)

    We report here the characterization of a five-generation large Chinese family with Leber's hereditary optic neuropathy (LHON). Very strikingly, six affected individuals of 38 matrilineal relatives (17 females/21 males) are exclusively males in this Chinese family. These matrilineal relatives in this family exhibited late-onset/progressive visual impairment with a wide range of severity, ranging from blindness to normal vision. The age of onset in visual impairment varies from 17 to 30 years. Sequence analysis of the complete mitochondrial genome in this pedigree revealed the presence of the G11778A mutation in ND4 gene and 29 other variants. This mitochondrial genome belongs to the Southern Chinese haplogroup B5b. We showed that the G11778A mutation is present at near homoplasmy in matrilineal relatives of this Chinese family but not in 164 Chinese controls. Incomplete penetrance of LHON in this family indicates the involvement of modulatory factors in the phenotypic expression of visual dysfunction associated with the G11778A mutation. However, none of other mtDNA variants are evolutionarily conserved and implicated to have significantly functional consequence. Thus, nuclear modifier gene(s) or environmental factor(s) seem to account for the penetrance and phenotypic variability of LHON in this Chinese family carrying the G11778A mutation

  2. Sexually transmitted diseases in homosexual and bisexual males from a cohort of human immunodeficiency virus negative volunteers (Project Horizonte, Belo Horizonte, Brazil

    Directory of Open Access Journals (Sweden)

    L Lignani Jr

    2000-12-01

    Full Text Available Sexually transmitted diseases (STD are very frequent in the whole world. Males who do not use a condom during their sexual relations are at great risk. We report cases of STD during six months of observation, among homosexual/bisexual males who participate in the Project Horizonte. There were 16 cases of genital warts, 6 cases of human immunodeficiency virus infection, 24 cases of unspecific urethritis, 28 cases of herpes simplex virus infection, 30 cases of syphilis, 58 cases of gonorrhea and 84 cases of pediculosis. We concluded that a condom must be used in all sexual relations and new counseling techniques are needed, to avoid this situation.

  3. Burden of disease resulting from chronic mountain sickness among young Chinese male immigrants in Tibet

    Directory of Open Access Journals (Sweden)

    Pei Tao

    2012-06-01

    Full Text Available Abstract Background In young Chinese men of the highland immigrant population, chronic mountain sickness (CMS is a major public health problem. The aim of this study was to measure the disease burden of CMS in this population. Methods We used disability-adjusted life years (DALYs to estimate the disease burden of CMS. Disability weights were derived using the person trade-off methodology. CMS diagnoses, symptom severity, and individual characteristics were obtained from surveys collected in Tibet in 2009 and 2010. The DALYs of individual patients and the DALYs/1,000 were calculated. Results Disability weights were obtained for 21 CMS health stages. The results of the analyses of the two surveys were consistent with each other. At different altitudes, the CMS rates ranged from 2.1-37.4%; the individual DALYs of patients ranged from 0.13-0.33, and the DALYs/1,000 ranged from 3.60-52.78. The age, highland service years, blood pressure, heart rate, smoking rate, and proportion of the sample working in engineering or construction were significantly higher in the CMS group than in the non-CMS group (p p  Conclusion The results show that CMS imposes a considerable burden on Chinese immigrants to Tibet. Immigrants with characteristics such as a higher residential altitude, more advanced age, longer highland service years, being a smoker, and working in engineering or construction were more likely to develop CMS and to increase the disease burden. Higher blood pressure and heart rate as a result of CMS were also positively associated with the disease burden. The authorities should pay attention to the highland disease burden and support the development and application of DALYs studies of CMS and other highland diseases.

  4. Floral Biology of Chinese Jujube (Ziziphus jujube Mill. I: The Formation of Microspores and Development of Male Gametes

    Directory of Open Access Journals (Sweden)

    Feng Zou

    2015-08-01

    Full Text Available Ziziphus jujube Mill is an economically important fruit tree, cultivated on marginal lands on a commercial scale, especially in China. In order to elucidate the microsporogenesis and male gametogenesis formation in Chinese jujube, a cultivar named ‘Lizao’ was employed for microscopy analysis. The results are showed that ‘Lizao’ was four ventricles in each anther and the anther wall was 4 to 5 layers. Its primary anther wall consisted of the epidermis, 1-2 layers endothecium, middle and glandular tapetum layers. The development of the anther wall conformed to the basic type. The meiosis in the microspore mother cells were belonged to a simultaneous type and most of the microspores were arranged in a tetrahedron shape in the tetrads. In the later May, the shape of pollen was a triangular germination vale with three germinal furrow and the mature pollen was of 2-cell type. Floral emergence and development lasted for 1 months-from later April to later May. Based our results, we did not find the abnormal male flower in the Z. jujube ‘Lizao’, suggesting that microsporogensis development may not be factors in the low seed production in the Z. jujube. This study provides the basis for understanding the biological mechanism regulating sexual reproduction, thus expanding the prospects for Z. jujube breeding programs and for further molecular and genetic studies of this species.

  5. α1A肾上腺素受体阻滞剂坦洛新在男性节育中的研究%Assessment of tamsulosin as a potential male contraceptive in healthy volunteers

    Institute of Scientific and Technical Information of China (English)

    刘运兴

    2016-01-01

    目的:探讨α1A 肾上腺素受体阻滞剂坦洛新在男性节育中的有效性和安全性。方法80名受试者随机分为2组(A 组和 B 组),按依次交叉的方式给予安慰剂和坦洛新(单次口服剂量为0.4 mg 或0.8 mg),每次给药之间有7天的间歇期。每次给药后4~6小时,评估每个受试者的射精情况,同时记录性欲和坦洛新的不良反应。结果服用0.8 mg 坦洛新后,所有受试者均发生了不射精症;服用0.4 mg 的坦洛新后,有功能的精子密度及有功能的精子总数显著减少,未出现明显的不良反应,服药前后及不同剂量各研究组均未出现性欲、性高潮的减退。结论α1A 肾上腺素受体阻滞剂坦洛新有男性抗生育的效果,可作为安全、有效、可逆的男性节育药。%Objective:To investigated the effectiveness and safety of tamsulosin as a potential male contraceptive. Methods:Eighty healthy male volunteers were enrolled. This study was in a placebo controlled,randomized and crossover de-sign. We administered placebo andtamsulosin(at a single oral dose of 0. 4mg or 0. 8mg)sequentially in a crossover manner in order to eliminate bias among drugs and doses. The volunteers were equally divided into two groups(A and B). Ejacu-latory profiles were assessed by masturbation 4 - 6 h after each administration,including conventional semen analysis and sperm count in midstream urine after ejaculation(in case of anejaculation). Libido and adverse effects of tamsulosin were onserved. Seven days after the last administration,endpoint ejaculatory profiles were evaluated in all volunteers by masturba-tion. Results:Anejaculation occurred in all subjects after taking 0. 8mg of tamsulosin. Total functional sperm count was sig-nificantly reduced in the subjects after taking 0. 4 mg of tamsulosin. All of the volunteers didn ˊt have a decrease in libido. Conclusion:Our results imply that tamsulosin has the effect of the male

  6. PHARMACOKINETIC AND BIOEQUIVALENCE COMPARISON BETWEEN EXTENDED RELEASE CAPSULES OF VENLAFAXINE HYDROCHLORIDE 150MG: AN OPEN LABEL, BALANCED, RANDOMIZED-SEQUENCE, SINGLE-DOSE, TWO-PERIOD CROSSOVER STUDY IN HEALTHY INDIAN MALE VOLUNTEERS

    Directory of Open Access Journals (Sweden)

    I.Sarath chandiran

    2011-03-01

    Full Text Available This bioequivalence study was designed to determine the pharmacokinetic, bioavailability and bioequivalence of Venlafaxine HCl 150 mg Extended Release Capsules in comparison with Effexor®-XR 150mg Extended Release Capsules after single dose administration under fed conditions in 20 healthy adult male subjects. Therefore the design of an open label, balanced, randomized, two-sequence, single dose, two way crossover study with a washout period of at least 7 days was used.Each volunteer received a 150 mg capsule of the reference or test drug respectively. On the day of dosing, blood samples were collected before dosing and at various time points up to 72 hours after dosing. Analysis of venlafaxine and its metabolite O-Desmethylvenlafaxine concentrations was performed using a validated liquid chromatography with tandem mass spectrometry (LC-MS/MS method. The pharmacokinetic parameters including Cmax, AUC0-t, AUC0-inf, Tmax, t1/2 and Kel were analyzed using the non-compartmental model. Drug safety and tolerability were assessed.The pharmacokinetic parameters including Cmax, AUC0-t, AUC0-inf, Tmax, t1/2 and Kel were analyzed using the non-compartmental model. Drug safety and tolerability were assessed. The primary pharmacokinetic parameters (Cmax, AUC0-t and AUC0-inf 90%CI were within the 80 to 125% interval required for bioequivalence as stipulated in the current regulations of the USFDA acceptance criteria. The geometric mean ratios (Test/Reference between the two products of extended-release venlafaxine capsule under fed condition were 104.91% (92.86%-118.53% and 114.41% (103.43%-124.55% for Cmax ratios, 102.24% (95.95%-108.94% and 105.27% (96.76%-114.53% for AUC0-t ratios and 101.66% (95.73%-107.97% and 104.71% (96.13%-114.05% for AUC0-inf ratios of Venlafaxine and its metabolite O-Desmethylvenlafaxine (ODV respectively. 20 volunteers had completed both treatment periods. There was no significant difference of the Tmax parameter between the two

  7. Observation on serum testosterone level cycles in a reared male chinese river dolphin (BAIJI)

    International Nuclear Information System (INIS)

    Objective: To study the biological significance of androgenic hormone level cycles in a reared male BAIJI dolphin. Methods: Serum testosterone levels were monthly determined with RIA in a reared BAIJI dolphin for 2 consecutive three years period(1996-98 and 2000-02). Blood samples were taken from the dorsal aspect of the tail between 10:00 to 11:00 a. m. around the 10th of each month. Results: Serum content of testosterone showed periodic changes with peaks yearly. In 1997, 1998, 1999, 2001, 2002 the peak was observed in April or May. In 2000 the peak were observed on July. Conclusion: The sexual glands of BAIJI dolphin were active from spring through autumn with a peak around April but inactive in winter. Our results suggested the BAIJI dolphin was a seasonally reproductively active animal. (authors)

  8. Effects of the genetic polymorphism CYP2 C19 on pharmacokinetics of citalopram in Chinese healthy volunteers%CYP2 C19遗传多态性对中国健康受试者西酞普兰代谢的影响

    Institute of Scientific and Technical Information of China (English)

    张丽娟; 田芳

    2014-01-01

    目的:研究中国健康男性受试者CYP2C19遗传多态性对西酞普兰体内代谢的影响。方法24名中国健康男性受试者空腹单次口服西酞普兰片20 mg,服药前采静脉血,乙二胺四乙酸( EDTA)抗凝,提取DNA,测定其基因型。分别在服药前和服药后一定时间点采静脉血各5 mL,离心取血浆,用HPLC-MS/MS法检测西酞普兰血药浓度,比较不同基因型受试者西酞普兰药代动力学的差异。结果2例受试者(8.33%)为CYP2C19慢代谢;10例为CYP2C19快代谢,其中纯合子12例(50%)、杂合子10例(41.67%)。西酞普兰的代谢受CYP2C19的基因多态性影响较大,但也可能受年龄和体重的影响。结论西酞普兰临床应用时应查明患者CYP2C19基因型,并参考其年龄、体重等情况给药。%Objective To investigate the effets of cytochrome CYP2C19 gene polymorphism on the pharmacokinetics of citalopram in Chinese healthy male volunteers.Methods Twenty-four Chinese healthy male volunteers were orally administered with a single dose of citalopram 20 mg.The venous blood samples were collected , using anticoagulantion EDTA to extract DNA, and the genotype was detected .The blood sam-ples(5 mL) from the bolunteers were collected before and after the ad-ministration of citalopram and plasma was taken .The plasma concentra-tion of citalopram was examined by HPLC -MS/MS method .The geno-type CYP2 C19 was measured by PCR -based sequencing.The measure-ments were performed by HPLC -MS/MS.Pharmacokinetic differences of citalopram on patients with different genotypes were compared .Results Two out of 24 volunteers were poor metabolizing genotype ( PM ) , and 22 were extensive metabolizers (EM).Among the EM 12 were homozy-gotes and 10 were heterozygotes.The pharmacokinetic of citalopram was largely influenced by CYP2 C19 genetic polymorphism , and also effected by the volunteers′age and weight.Conclusion The CYP2 C19 genotype of

  9. Does Pay Motivate Volunteers?

    OpenAIRE

    Bruno S. Frey; Götte, Lorenz

    1999-01-01

    Volunteer work is an increasingly large, yet ill-understood sector of the economy. We show that monetary rewards undermine the intrinsic motivation of volunteers. A unique data set from Switzerland allows us to assess the effects of financial rewards on the effort put into volunteer work. There is a fairly standard pattern regarding the volunteers reaction e.g. to more labor market work hours. But we obtain the puzzling result that, when rewarded, volunteers work less. These findings are in l...

  10. The management of volunteers

    OpenAIRE

    Simona Mihaela Haivas

    2009-01-01

    Volunteering is consider to be any activity intended to help others that is provided without obligation for which the volunteer does not receive pay or other material compensation. Given the role and the importance of volunteering as a productive resource, the non – profit organizations mainly driven by volunteers need to have a good management of these resources, which could be a tricky issue considering the lack of any financial rewards. After a short briefing of the role of volunteering an...

  11. Pressure/cross-sectional area relations in the proximal urethra of healthy males: the time dependent pressure response following forced dilation. Part IV: results in healthy volunteers

    DEFF Research Database (Denmark)

    Bagi, Per; Bøtker-Rasmussen; Kristensen, Jørgen Kvist

    2002-01-01

    The significance of the anatomical location and age on the urethral response to a sudden forced dilation was studied in 30 healthy males aged 23-85 years. The pressure decay after dilation was fitted with a double exponential function of the form: P(t) = P(equ) + P(alpha)e(-t/tau(alpha) + P......(beta)e(t/tau(beta) where P(t) is pressure at time t, P(equ) is equilibrium pressure after dilation, P(alpha) and P(beta) are pressure decay, and tau(alpha) and tau(beta) are time constants. The pressure response was highly affected by the location of the measurement, with the maximum values of the pressure components in...... the pressure decay following dilation proved significantly related to age in all urethral segments. The causal background for this correlation is uncertain, but may be discovered in age dependent changes in the periluminal tissue composition, or in changing neuromuscular activity in these structures....

  12. Genetic Variation in BCL2 3′-UTR Was Associated with Lung Cancer Risk and Prognosis in Male Chinese Population

    OpenAIRE

    Xu, Ping; Liu, Li; Wang, Jianzhong; Zhang, Kai; Hong, Xiaohua; Deng, Qifei; Xiang, Jingjun; Zhang, Xiaomin; He, Meian; WU, TANGCHUN; Guo, Huan

    2013-01-01

    Objectives Bcl-2 is a critical apoptosis inhibitor with established carcinogenic potential, and can confer cancer cell resistance to therapeutic treatments by activating anti-apoptotic cellular defense. We hypothesized that genetic variants of BCL2 gene may be associated with lung cancer susceptibility and prognosis. Methods Three selected tagSNPs of BCL2 (rs2279115, rs1801018, and rs1564483) were genotyped in 1017 paired male Chinese lung cancer cases and controls by TaqMan assay. The associ...

  13. My Volunteer Life

    Institute of Scientific and Technical Information of China (English)

    FengAi

    2004-01-01

    SEVERAL years ago, I read a notice soliciting volunteer teachers to work in the west.It caught my interest and I clipped it. Upon graduation in August 2000, 1 postponed my graduate stud-ies in sociology and joined the Fudan Team of China Youth Volunteer Aid.My one-year volunteer life began in

  14. Pharmacokinetics of tenofovir disoproxil fumarate capsule in Chinese volunteers%富马酸替诺福韦二吡呋酯胶囊在中国人体内的药代动力学

    Institute of Scientific and Technical Information of China (English)

    姜莉苑; 丁黎; 钟水生; 刘冰; 陈迪; 文爱东

    2013-01-01

    To investigate the pharmacokinetics of tenofovir disoproxil fumarate (TDF) capsule in Chinese volunteers.A phase Ⅰ,3-period study was performed in healthy Chinese subjects.12 Healthy subjects received either single 300 mg,multiple 300 mg and single 600 mg doses of TDF under fasted conditions,or received single 300 mg doses under fed condition.For 300 mg and 600 mg single administration of TDF,the cmax data were (305.4 ±96.4) and (590.0 ± 149.6) ng/mL,respectively,and the AUC0-72 h data were (2 396 ± 489) and (4 465 ±1 042) ng· h/mL,respectively.In the dose range of 300-600 mg,tenofovir demonstrated linear pharmacokinetic characteristics in Chinese volunteers.No significant gender difference in the pharmacokinetic parameters was found.High fat food decreased the absorption rate of tenofovir,but increased its exposure.In the multiple-dose study at 300 mg dose for 7 consecutive days,the degree of fluctuation (DF) was 2.7 ± 0.6,and the accumulation parameter (Rcmax) and (RAUC) were 1.3 ±0.3 and 1.7 ±0.4,respectively.Compared with the single dose administration,an increased exposure of 70% in AUC0-τ of tenofovir was observed after a multiple administration.%研究富马酸替诺福韦二吡呋酯胶囊在中国人体内的药代动力学特征.12名健康受试者依次进行低剂量(300mg)单、多次给药;高(600 mg)剂量单次给药和低剂量饮食影响单次给药的药代动力学试验,计算药代动力学参数.受试者单次口服300 mg和600 mg受试制剂后,替诺福韦的cmax分别为(305.4±96.4)和(590.0±149.6)ng/mL,AUC0-72h分别为(2 396±489)和(4 465±1 042) ng·h/mL,t1/2分别为(19.9±2.4)和(21.9±3.0)h.结果显示替诺福韦在300 ~ 600 mg剂量范围内呈现线性药代动力学特征,体内过程不受性别差异的影响.与空腹给药相比,高脂餐后给药的tmax延后1.6h,AUC0-72 h提高约32%.多次给药达稳态后,替诺福韦的稳态血药浓度波动度为2.7±0.6,累积常数Rcmax为1.3±0.3,RAUC为1

  15. 盐酸利托君片在中国健康人体的生物等效性%Bioequivalence of ritodrine hydrochloride tablets in Chinese healthy volunteers

    Institute of Scientific and Technical Information of China (English)

    张佳丽; 吴华; 潘世芬; 王鹤尧

    2012-01-01

    目的 评价2种国产盐酸利托君片在中国健康人体的生物等效性.方法 22名健康女性受试者随机交叉单剂量口服盐酸利托君片试验药物或对照药物,各10 mg.用高效液相色谱-串联质谱法测定血浆中盐酸利托君浓度;用DAS2.0软件计算药代动力学参数,并对2种药物进行生物等效性评价.结果 试验药物和对照药物的主要药代动力学参数:Cmax分别为(5.71±1.83)和(5.61±2.03)ng·mL-1;Tmax分别为(0.54±0.45)和(0.46 ±0.24) h;t1/2分别为(3.64±3.99)和(4.25±4.02)h;AUC0-t分别为(12.31±5.20)和(12.01±5.42)h·ng·mL-1.AUC0-t、AUC0-∞、Cmax的90%可信区间分别为95.8%~111.6%、92.3% ~ 118.9%和95.4% ~ 108.2%.试验药物相对于对照药物的生物利用度F为(105.3±19.96)%.结论 试验药物和对照药物生物等效.%Objective To evaluate the bioequivalence of two preparations of ritodrine hydrochloride tablets. Methods A single oral dose of 10 mg test and reference ritodrine hydrochloride tablets were given to 22 female healthy volunteers in a randomized crossover study. The concentrations of ritodrine hydrochloride were determined by HPLC - MS /MS method. The pharmacokinetic paramters and relative bioavailability were calculated by DAS 2. 0 software, then the bioequivalence was judged. Results The main pharmacokinetic parameters of two preparations were as follows; CmaXwere (5.71 ±1.83), (5.61 ±2.03) ng · mL-1, Tmax were (0. 54 ±0. 45), (0. 46 ±0. 24) h, t1/2were(3. 64 ±3. 99), (4. 25 ±4.02) h, AUC0_t were(12. 31 ±5.20), (12.01 ±5.42) h · ng · mL -1, respectively. The relative bioavailability of test tablets was (105. 3 ± 19. 96) % . The 90% Cis for the ratios of AUC0_t, Cmax were 95. 8% - 111. 6% , 95.4% - 108. 2% , respectively. Conclusion The results demonstrated that the two preparations were bioequivalent.

  16. Kinetics of di(2-ethylhexyl) phthalate (DEHP) and mono(2-ethylhexyl) phthalate in blood and of DEHP metabolites in urine of male volunteers after single ingestion of ring-deuterated DEHP

    International Nuclear Information System (INIS)

    The plasticizer di(2-ethylhexyl) phthalate (DEHP) is suspected to induce antiandrogenic effects in men via its metabolite mono(2-ethylhexyl) phthalate (MEHP). However, there is only little information on the kinetic behavior of DEHP and its metabolites in humans. The toxikokinetics of DEHP was investigated in four male volunteers (28–61 y) who ingested a single dose (645 ± 20 μg/kg body weight) of ring-deuterated DEHP (DEHP-D4). Concentrations of DEHP-D4, of free ring-deuterated MEHP (MEHP-D4), and the sum of free and glucuronidated MEHP-D4 were measured in blood for up to 24 h; amounts of the monoesters MEHP-D4, ring-deuterated mono(2-ethyl-5-hydroxyhexyl) phthalate and ring-deuterated mono(2-ethyl-5-oxohexyl) phthalate were determined in urine for up to 46 h after ingestion. The bioavailability of DEHP-D4 was surprisingly high with an area under the concentration-time curve until 24 h (AUC) amounting to 50% of that of free MEHP-D4. The AUC of free MEHP-D4 normalized to DEHP-D4 dose and body weight (AUC/D) was 2.1 and 8.1 times, that of DEHP-D4 even 50 and 100 times higher than the corresponding AUC/D values obtained earlier in rat and marmoset, respectively. Time courses of the compounds in blood and urine of the volunteers oscillated widely. Terminal elimination half-lives were short (4.3–6.6 h). Total amounts of metabolites in 22-h urine are correlated linearly with the AUC of free MEHP-D4 in blood, the parameter regarded as relevant for risk assessment. -- Highlights: ► After DEHP intake, DEHP and MEHP in blood show oscillating time courses. ► Dose-related blood levels of DEHP are 50 times higher in humans than in rats. ► Dose-related blood levels of free MEHP are 2 times higher in humans than in rats. ► Elimination of DEHP and its metabolites is short with half-lives of 4.3-6.6 h.

  17. Kinetics of di(2-ethylhexyl) phthalate (DEHP) and mono(2-ethylhexyl) phthalate in blood and of DEHP metabolites in urine of male volunteers after single ingestion of ring-deuterated DEHP

    Energy Technology Data Exchange (ETDEWEB)

    Kessler, Winfried, E-mail: kessler@helmholtz-muenchen.de [Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, D-85764 Neuherberg (Germany); Numtip, Wanwiwa [Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, D-85764 Neuherberg (Germany); Völkel, Wolfgang; Seckin, Elcim [Department of Chemical Safety and Toxicology, Bavarian Health and Food Safety Authority, Pfarrstrasse 3, D-80538 München (Germany); Csanády, György A. [Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, D-85764 Neuherberg (Germany); Institut für Toxikologie und Umwelthygiene, Technische Universität München, München (Germany); Pütz, Christian [Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, D-85764 Neuherberg (Germany); and others

    2012-10-15

    The plasticizer di(2-ethylhexyl) phthalate (DEHP) is suspected to induce antiandrogenic effects in men via its metabolite mono(2-ethylhexyl) phthalate (MEHP). However, there is only little information on the kinetic behavior of DEHP and its metabolites in humans. The toxikokinetics of DEHP was investigated in four male volunteers (28–61 y) who ingested a single dose (645 ± 20 μg/kg body weight) of ring-deuterated DEHP (DEHP-D{sub 4}). Concentrations of DEHP-D{sub 4}, of free ring-deuterated MEHP (MEHP-D{sub 4}), and the sum of free and glucuronidated MEHP-D{sub 4} were measured in blood for up to 24 h; amounts of the monoesters MEHP-D{sub 4}, ring-deuterated mono(2-ethyl-5-hydroxyhexyl) phthalate and ring-deuterated mono(2-ethyl-5-oxohexyl) phthalate were determined in urine for up to 46 h after ingestion. The bioavailability of DEHP-D{sub 4} was surprisingly high with an area under the concentration-time curve until 24 h (AUC) amounting to 50% of that of free MEHP-D{sub 4}. The AUC of free MEHP-D{sub 4} normalized to DEHP-D{sub 4} dose and body weight (AUC/D) was 2.1 and 8.1 times, that of DEHP-D{sub 4} even 50 and 100 times higher than the corresponding AUC/D values obtained earlier in rat and marmoset, respectively. Time courses of the compounds in blood and urine of the volunteers oscillated widely. Terminal elimination half-lives were short (4.3–6.6 h). Total amounts of metabolites in 22-h urine are correlated linearly with the AUC of free MEHP-D{sub 4} in blood, the parameter regarded as relevant for risk assessment. -- Highlights: ► After DEHP intake, DEHP and MEHP in blood show oscillating time courses. ► Dose-related blood levels of DEHP are 50 times higher in humans than in rats. ► Dose-related blood levels of free MEHP are 2 times higher in humans than in rats. ► Elimination of DEHP and its metabolites is short with half-lives of 4.3-6.6 h.

  18. Volunteers in Sport Organizations

    Directory of Open Access Journals (Sweden)

    VESNA CILERDZIC

    2010-01-01

    Full Text Available The research is done in order to describe student’s attitudes on volunteering in sport. The sample consists of 231 students from Serbia, average age 21,06±3,12years. They were from eight colleges and faculties. For nominal and ordinal variables, frequencies were determined. Many of examined students have volunteering experiences. The results confirm that students believe that we live in a society which his generally thought only to its own benefit; they think that volunteering can not solve the problems in society; that people do not have enough experience with volunteering and people do not have time to volunteering; volunteering is for young people; in their family and among friends, there are no volunteers; everyone could be volunteer only if that wishes; do not believe that volunteering is a waste of time and it helps in future career. The prevalent number of students, regardless of the Faculty which they belong, rarely volunteered in areas outside of sport. Results also shows that students from sport faculties have less experience in volunteering in sport than students from other faculties, but this difference is not dramatic.

  19. Characterization and expression profiling of MYB transcription factors against stresses and during male organ development in Chinese cabbage (Brassica rapa ssp. pekinensis).

    Science.gov (United States)

    Saha, Gopal; Park, Jong-In; Ahmed, Nasar Uddin; Kayum, Md Abdul; Kang, Kwon-Kyoo; Nou, Ill-Sup

    2016-07-01

    organ-specific expression data, we identified nine R2R3-MYBs that were constitutively expressed in male reproductive tissue, which may provide an important key for studying male sterility in Chinese cabbage. The extensive annotation and transcriptome profiling reported in this study will be useful for understanding the involvement of MYB genes in stress resistance in addition to their growth regulatory functions, ultimately providing the basis for functional characterization and exploitation of the candidate MYB genes for genetic engineering of Chinese cabbage. PMID:27038155

  20. The CFTR polymorphisms poly-T, TG-repeats and M470V in Chinese males with congenital bilateral absence of the vas deferens

    Institute of Scientific and Technical Information of China (English)

    Wu-Hua Ni; Lei Jiang; Qian-Jin Fei; Jian-Yuan Jin; Xu Yang; Xue-Feng Huang

    2012-01-01

    Congenital bilateral absence of the vas deferens (CBAVD) is a frequent cause of obstructive azoospermia,and mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene have also been frequently identified in patients with CBAVD.However,the distribution of the CFTR polymorphisms M470V,poly-T,TG-repeats and F508del mutation in the Chinese CBAVD population with presumed low cystic fibrosis (CF) frequency remains to be evaluated.Samples obtained from 109 Chinese infertile males with CBAVD and 104 normal controls were analyzed for the presence of CFTR (TG)m(T)n,M470V and F508del by PCR amplification followed by direct sequencing.Our study showed that the F508del mutation was not found in our patients.The 5T mutation was present with high frequency in Chinese CBAVD patients and IVS8-5T linked to either 12 or 13 TG repeats was highly prevalent among CBAVD patients (97.22% of 72 cases and 96.91% of 97 alleles with IVS8-5T).Moreover,a statistically significant relationship between TG12-5T-V470 haplotype and CBAVD was detected.This study indicated that the CFTR polymorphisms poly-T,TG-repeats and M470V might affect the process of CBAVD in the Chinese population.

  1. 莫西沙星在中国健康受试者体内的药代动力学研究%Pharmcokinetics of moxifloxacin in Chinese healthy volunteers

    Institute of Scientific and Technical Information of China (English)

    刘银萍; 秦玉花; 白楠; 唐铭婧; 王睿; 赵红伟

    2015-01-01

    Objective To study the pharmacokinetics of oral administra-tion of moxifloxacin in Chinese healthy volunteers .Methods The study was designed as an open , randomized , parallel and single -dose cycle study.The volunteers were administered with a single dose of moxifloxa-cin 400 mg for consistent four days , respectively.The plasma concentra-tions of moxifloxacin were determined by LC -MS/MS method. The pharmacokinetic parameters of moxifloxacin were calculated by WinNon-lin 5.2.1 software.Results Six subjects quit from the study , and the main pharmacokinetic parameters of the remaining 42 subjects were as follows:t1/2 was (11.71 ±3.53 ) h, Cmax was (0.51 ±0.19 ) ×10 -4 ng・ mL-1, tmax was(2.94 ±1.41) h, MRT0-24 hwas(18.02 ±4.45)h, CLz/F was ( 0.84 ± 0.75 ) × 10 -4 mL ・ h-1 , AUC0-24 h was (5.82 ±1.82 ) ×10 -4 ng・ mL-1・ h.Conclusion The characteristics of oral moxifloxacin 400 mg has shown a high blood concentration , long half-life time and it can be well tolerated.The doses adopted in foreign study is recommended .There was a gender difference in volunteers when with same dose of moxifloxacin .%目的:评价中国健康受试者连续4 d单剂量口服盐酸莫西沙星片400 mg的药代动力学。方法开放、随机、平行、单次、单周期试验设计。48名健康受试者,男女各半,单剂量口服盐酸莫西沙星片400 mg,连续4 d,用高效液相色谱串联质谱法测定血药浓度,用 WinNonlin 5.2.1程序计算药代动力学参数。结果有6例受试者中途退出,其余42名健康受试者口服莫西沙星后的主要药代动力学参数如下, t1/2为(11.71±3.53) h, Cmax为(0.51±0.19)×10-4 ng・ mL-1, tmax为(2.94±1.41) h, MRT 0-24 h为(18.02±4.45) h, CLz/F 为(0.84±0.75)×10-4 mL・ h-1,AUC0-24 h为(5.82±1.82)×10-4 ng・ mL-1・ h。结论我国健康受试者口服莫西沙星血药浓度高、半衰期长、耐受性好,可参照国外剂量,并且

  2. Social Volunteer Computing

    Directory of Open Access Journals (Sweden)

    Adam Mcmahon

    2011-08-01

    Full Text Available While both volunteer computing and social networks have proved successful, the merging of these two models is a new field: Social Volunteer Computing. A Social Volunteer Computing system utilizes the relationships within a social network to determine how computational resources flow towards tasks that need to be completed, and the results of these computations are added back into the social network as content. Such a system will provide scientists and artists a new facility to obtain computational resources and disseminate their work. RenderWeb 2.0, a prototype Social Volunteer Computing system, is introduced that allows animations created in Blender to be distributed and rendered within Facebook.

  3. The relationships among perceived organizational support, intention to remain, career success and self-esteem in Chinese male nurses

    OpenAIRE

    Jing-ying Liu; Ji-peng Yang; Yang Yang; Yan-hui Liu

    2015-01-01

    Aim: The purpose of this study was to investigate the relationships among perceived organizational support, intention to remain, career success and self-esteem in male nurses in China. Background: Recently, turnover is considered increasingly more normal. Male nurses could be stabilized by improving their perceived organizational support, career success and self-esteem. Design: A cross-sectional design was used in the present study. Method: 405 full-time male Registered Nurses, from ...

  4. Recruiting Today's Volunteer Corps.

    Science.gov (United States)

    Paresky, Susan S.

    1994-01-01

    College and university development officers are encouraged to adjust their expectations of volunteers to the current reality of graduates' schedules and commitments. Five barriers to volunteering (economic, time and distance, language and cultural, environmental, and competitive) are identified, and techniques for overcoming them are offered. (MSE)

  5. Effect of Chinese traditional medicine anti-fatigue prescription on the concentration of the serum testosterone and cortisol in male rats under stress of maximum intensive training

    International Nuclear Information System (INIS)

    Objective: To study the effect of chinese traditional medicine anti-fatigue prescription on the concentration of the serum testosterone (T) and cortisol (C) in male rats under the stress of maximum intensive training. Methods: Wistar male rat models of stress under maximum intensity training were established (n=40) and half of them were treated with Chinese traditional medicine anti-fatigue prescription twenty undisturbed rats served as controls. Testosterone and cortisol serum levels were determined with RIA at the end of the seven weeks' experiment. Results: Maximum intensive training would cause the level of the serum testosterone lowered, the concentration of the cortisol elevated and the ratio of T/C reduced. The serum T levels and T/C ratio were significantly lower and cortisol levels significantly higher in the untreated models than those in the treated models and controls (P<0.01). The levels of the two hormones were markedly corrected in the treated models with no significantly differences from those in the controls. However, the T/C ratio was still significantly lower than that in the controls (P <0.05) due to a relatively slightly greater degree of reduction of T levels. Conclusion: Anti-fatigue prescription can not only promote the recovery of fatigue after the maximum intensive training but also strengthen the anabolism of the rats. (authors)

  6. 苯扎贝特在中国汉族和藏族健康人体内的药动学初探%Pharmacokinetics of bezafibrate in Chinese Han and Tibetan healthy volunteers

    Institute of Scientific and Technical Information of China (English)

    李忠亮; 张治然; 袭荣刚

    2012-01-01

    Objective To determine the pharmacokinetics of bezafibrate tablets after a single oral dose in Han and Tibetan healthy volunteers. Methods Ten healthy Han volunteers and 10 healthy Tibetan volunteers enrolled in the study. Each subject received a single dose of 400 mg bezafibrate tablets. The plasma concentration was determined by HPLC. The pharmacokinetic parameters were calculated by DAS and statistically analyzed by SPSS. Results The main pharmacokinetic parameters of Chinese Han were as follows: Cmax (11.33±3.02) μg · mL-1, tmax (1.96±0. 21) h, t1/2 (2.05±0.37) h, AUC0-12 (40. 54± 11. 25) μg · H · mL-1, and AUC0-∞ (46. 63 ±12. 42) μg · H · mL-1. The main pharmacokinetic parameters of Tibetan were as follows- C (11.17±3. 26) μg · mL-1, tmax(2. 05±0. 32) h, t1/2 (2.04±0.31) h, AUC0-12 (38.25±9.74) μg · H · mL-1, and AUC0-∞ (44. 52± 10. 35) vg · H · mL-1. Conclusion The plasma concentration-time curve of bezafibrate fits a two-compartment open model. Due to the small number of volunteers in the trial, further research is needed.%目的 研究汉族和藏族健康志愿者单剂量口服苯扎贝特片的药物动力学.方法 健康志愿者20名(其中汉族和藏族各10名,男女各半),单剂量口服笨扎贝特片400 mg,采用HPLC法测定血浆中苯扎贝特的含量.用DAS软件程序进行数据处理,用SPSS软件对不同性别药动学参数进行统计分析.结果 受试者单剂量口服400 mg苯扎贝特片后,汉族健康志愿者的主要药动学参数:Gmax为(11.33±3.02)μg·mL-1,tamx为(1.96±0.21)h,t1/2为(2.05±0.37)h,AUC0-12为(40.54±11.25)μg·h·mL-1;AUC0~∞为(46.63±12.42)μg·h·mL-1.藏族健康志愿者的主要药动学参数:Cmax为(11.17±3.26)μg·mL-1,tmax为(2.05±0.32)h,t1/2为(2.04±0.31)h,AUC0~12为(38.25±9.74)μg·h·mL-1; AUC0-∞为(44.52±10.35)μg·b·mL-1.结论 健康志愿者单剂量口服苯扎贝特片的体内药动学过程符合二室开放模型.由于样本数太少,

  7. Bioequivalence of Clarithromycin soft capsules in healthy Chinese volunteers%克拉霉素软胶囊在中国健康人体的生物等效性研究

    Institute of Scientific and Technical Information of China (English)

    马萍; 李鹏飞; 王淑民; 汪娟; 王燕; 谢晓娟; 刘丽宏

    2012-01-01

    AIM: To evaluate the bioequivalence of Clarithromycin soft capsule in healthy Chinese volunteers. METHODS: A single oral doses of 0. 25 g Clarithromycin soft capsule and tablet (test and reference) were given to 20 healthy volunteers according to an open randomized crossover design. The concentrations of Clarithromycin in plasma were determined by LC-MS/MS. With the aid of BAPP2. 0.the bioequivalence of the test and reference preparation were calculated by analysis of variance, tow one sided t-test. RESULTS: The pharmacokinetic parameters of the two preparations were as follow ;tmax of test drug and reference drug were (2. 1 ± 0. 6),(2.0 + 0. 8)h, Cmax were(815 + 191),(800 ±200) ng/mL, t1/2 were (4. 0 + 0. 4)、 (3. 9 ± 0.5) h, AUC0-24, were (5612 ± 1283), (5246 ± 1375) ng·h·mL-1, AUC0-∞ were (5722 ± 1313),(5339± 1402) ng · h · mL-1 , respectively. The relative bioavailability of the test formulation were (110.5 + 23.9)%. CONCLUSION: The tested preparation was of bioequivalence to the reference preparation.%目的:评价受试制剂克拉霉素软胶囊与参比制剂克拉霉素片在中国健康人体中的生物等效性.方法:采用双周期随机交叉试验设计,入选20名男性健康受试者单剂空腹口服参比制剂和受试制剂0.25g,采用液相色谱-串联质谱法(LC-MS/MS)测定血浆中克拉霉素的浓度,经BAPP2.0软件处理参数,并进行双单侧t检验确定是否生物等效.结果:主要药代动力学参数:受试制剂和参比制剂克拉霉素的达峰时间tmax分别为(2.1±0.6)、(2.0±0.8)h;Cmax分别为(815±191)、(800±200)ng/mL;t1/2分别为(4.0±0.4)、(3.9±0.5)h;AUC0-24h分别为(5612±1283)、(5246±1375)ng·h·mL-1;AUC0-∝分别 为 (5722 ± 1313)、 (5339 ±1402) ng·h·mL-1.受试制剂与参比制剂的相对生物利用度为(110.5±23.9)%.结论:受试制剂克拉霉素软胶囊与参比制剂克拉霉素片生物等效.

  8. Male partners' attachment styles as predictors of women's coerced first sexual intercourse in Chinese college students' dating relationships.

    Science.gov (United States)

    He, Shanshan; Tsang, Sandra

    2014-01-01

    Attachment theory has great potential to help our understanding of the apparent contradiction between violence and intimacy. Yet very few studies applied this theory to explain or predict sexual coercion in the context of intimate relationships. This study examined the relation between male partners' attachment styles and women's coerced first sexual intercourse in dating relationships. There were 927 valid questionnaires collected by purposive snowball sampling in five main cities in China to college students who were currently in a romantic relationship. Results showed that in both male and female samples, male partners' anxious attachment style were significantly and positively predicted emotional manipulation coercive tactics. In the female sample, male partners' two attachment styles (anxious and avoidant) positively predicted violence threat tactics, and male partners' avoidant attachment style positively predicted defection threat tactics. The research hypothesis of this study has been successfully supported, and implications and limitations were discussed. PMID:25905127

  9. My volunteer work

    Institute of Scientific and Technical Information of China (English)

    卫子辰

    2015-01-01

    <正>As we all know,being a volunteer can help us learn many things,such as new skills,staying active,improving our social skills,accumulating work experience,making new friends with those who have the same topic,helping us grow more rapidly...I can still recall the days when I worked as a volunteer in a hospital in my city.The unforgetable experience was not only a volunteer work,but also a small society to me.It was in the summer vocation after high school entrance examination,when I had nothing to do but to play computer

  10. Positive resources for combating depressive symptoms among Chinese male correctional officers: perceived organizational support and psychological capital

    OpenAIRE

    Liu, Li; Hu, Shu; Wang, Lie; Sui, Guoyuan; Ma, Lei

    2013-01-01

    Background Although correctional officers (COs) clearly suffer from depression, positive resources for combating depression have been rarely studied in this population. The purpose of the study was to examine the associations of perceived organizational support (POS) and psychological capital (PsyCap) with depressive symptoms among Chinese COs. Methods A cross-sectional survey was conducted in a province of northeast China during March–April 2011. A self-administered questionnaire was distrib...

  11. NASTEP Volunteer Request (CSA)

    Data.gov (United States)

    Department of Transportation — Allows users to add themselves to a Service Area wide ?volunteer for emergency duty? list (was created after Gulf Coast Hurricanes). Approval and email by managers,...

  12. Volunteering and Organizational Diversity

    DEFF Research Database (Denmark)

    Henriksen, Lars Skov; Rosdahl, David

    2008-01-01

    understanding of why people donate some of their scarce time to different types of volunteering. The survey is based upon a random sample of 4.200 persons aged 16-85, drawn from the Central Population Register. The response rate was 75 percent and interviews were obtained through phone interviewing conducted...... with the characteristics of the Danish adult population suggests that the sample is representative as regards gender, age, and place of living. However, respondents with non-western citizenship are under-represented in the study. In the survey respondents were probed about formal volunteering within 14 different fields...... accomplish some desired end (Smith 1981:33). The question of why people volunteer is thus guided towards factors governing entry and exit from ‘the volunteer labour market' (Wilson and Musick 1999:244). The following three different forms of resources or capital are identified as being of crucial importance...

  13. 中国男性导演视角下的女性%The feminism of the Chinese male director’s perspective

    Institute of Scientific and Technical Information of China (English)

    刘君

    2013-01-01

      随着女性意识的觉醒,很多中国男性导演也开始了对这一领域的关注,所以男性导演视角下的女性也形形色色。男性导演采用女性视角阐述作品作为一种较为新奇的文化现象具有其独特的文化意义。本文通过对男性导演和女性导演关于女性视角的对比,阐述了男导演采用女性视角所体现的文化意义。%With the disenchantment of female consciousness, a lot of Chinese male directors also begin to pay much attention to this domain, and they adopt female perspective to their own works. Through the comparison of the male and female directors' opinions about female perspective, the essay analyses the same and different characteristics of female perspective which is adopted by male directors, and demonstrates the social significance of this phenomenon.

  14. Chronic Δ(9)-Tetrahydrocannabinol Administration Reduces IgE(+)B Cells but Unlikely Enhances Pathogenic SIVmac251 Infection in Male Rhesus Macaques of Chinese Origin.

    Science.gov (United States)

    Wei, Qiang; Liu, Li; Cong, Zhe; Wu, Xiaoxian; Wang, Hui; Qin, Chuan; Molina, Patricia; Chen, Zhiwei

    2016-09-01

    Delta9-tetrahydrocannabinol (Δ(9)-THC) is the major psychoactive component of the cannabis plant. Δ(9)-THC has been used in the active ingredient of Marinol as an appetite stimulant for AIDS patients. Its impact on progression of HIV-1 infection, however, remains debatable. Previous studies indicated that Δ(9)-THC administration enhanced HIV-1 infection in huPBL-SCID mice but seemingly decreased early mortality in simian immunodeficiency virus (SIV) infected male Indian-derived rhesus macaques. Here, we determine the chronic effect of Δ(9)-THC administration using 0.32 mg/kg or placebo (PBO), i.m., twice daily for 428 days on SIVmac251 infected male Chinese-derived rhesus macaques. Sixteen animals were divided into four study groups: Δ(9)-THC(+)SIV(+), Δ(9)-THC(+)SIV(-), PBO/SIV(+) and PBO/SIV(-) (n = 4/group). One-month after daily Δ(9)-THC or PBO administrations, macaques in groups one and three were challenged intravenously with pathogenic SIVmac251/CNS, which was isolated from the brain of a Chinese macaque with end-staged neuroAIDS. No significant differences in peak and steady state plasma viral loads were seen between Δ(9)-THC(+)SIV(+) and PBO/SIV(+) macaques. Regardless of Δ(9)-THC, all infected macaques displayed significant drop of CD4/CD8 T cell ratio, loss of CD4(+) T cells and higher persistent levels of Ki67(+)CD8(+) T cells compared with uninfected animals. Moreover, long-term Δ(9)-THC treatment reduced significantly the frequency of circulating IgE(+)B cells. Only one Δ(9)-THC(+)SIV(+) macaque died of simian AIDS with paralyzed limbs compared with two deaths in the PBO/SIV(+) group during the study period. These findings indicate that chronic Δ(9)-THC administration resulted in reduction of IgE(+)B cells, yet it unlikely enhanced pathogenic SIVmac251/CNS infection in male Rhesus macaques of Chinese origin. PMID:27109234

  15. Volunteering in sport clubs

    OpenAIRE

    Nagel, Siegfried; Schlesinger, Torsten

    2014-01-01

    Volunteers are the most important resource for non-profit sport clubs seeking to bolster their viability (e.g. sporting programs). Although many people do voluntary work in sport clubs, stable voluntary engagement can no longer be granted. This difficulty is confirmed by existing research across various European countries. From a club management point of view, a detailed understanding of how to attract volunteers and retain them in the long term is becoming a high priority. The purpose of thi...

  16. 盐酸美金刚片在中国健康人体的生物等效性%Study on the bioequivalence of memantine hydrochloride tablets in Chinese healthy volunteers

    Institute of Scientific and Technical Information of China (English)

    郑恒; 周华; 任丽; 钱振宇; 彭彦

    2012-01-01

    目的:评价国产与进口盐酸美金刚片在中国健康人体的生物等效性.方法:20名健康男性受试者随机交叉单剂量口服受试制剂或参比制剂盐酸美全刚片各10 mg.用高效液相色谱-串联质谱法测定血浆中美金刚浓度;用DAS3.0软件计算药动学参数,并对两种药物进行生物等效性评价.结果:受试制剂和参比制剂的主要药动学参数:Cmax分别为(18.1±3.8)和(20.3±4.2)ng·mL-1;tmax分别为(12.7±15.1)和(8.8±3.0)h;t1/2分别为(60.8±15.5)和(61.4±19.2)h;AUC0-t分别为(1748.6±338.9)和(1720.2±317.3)ng·h·mL-1.AUC0-t、AUC0-∞、Cmax的90%置信区间分别为89.8%~105.6%、89.7%~106.1%、84.8%~93.9%.受试制剂相对生物利用度F0-t为(95.5±2.9)%.结论:受试制剂与参比制剂具有生物等效性.%OBJECTIVE To evaluate the bioequivalence of two preparations of memantine hydrochloride in healthy volunteers. METHODS A single oral dose of 10 mg test preparation or reference preparation memantine hydrochloride tablets were given to 20 male healthy volunteers in a randomized crossover study. The concentrations of memantine were determined by HPLC-MS/MS method. The pharmacokinetic parameters and relative bioavailability were calculated by DAS 3. 0 software, and then the bioequivalence was judged. RESULTS The main pharmacokinetic parameters of test preparation and reference preparation were as follows: Cmax was (18. 1 ±3.8), (20. 3 ±4. 2) ng·mL-1; t max was (12. 7 ± 15. 1), (8.8 ± 3.0) h; t1:2 was (60.8 + 15.5), (61. 4 ± 19.2) h; AUC0-t was (1 748. 6 ± 338. 9). (1 720. 2 ± 317. 3) ng·h· mL-1 , respectively. The 90% CIs for the ratios of AUG0-T、AUG0-∞ ,C max were 89. 8% ~1()5. 6%,89. 7%~106. 1%,84. 8%~93. 9%, respectively. The relative bioavailability of test preparation was (95.5 ±2. 9)%. CONCLUSION The results demonstrated that the two preparations were bioequivalent.

  17. Institutional Facilitation in Sustained Volunteering among Older Adult Volunteers

    Science.gov (United States)

    Tang, Fengyan; Morrow-Howell, Nancy; Hong, Songiee

    2009-01-01

    As more nonprofit organizations rely on older adult volunteers to provide services, it is important to retain volunteers for an extended period of time to ensure service quality and the beneficial outcomes of volunteering. Nonprofit organizations are positioned to facilitate older adult volunteers' role performance. Based on an institutional…

  18. The presence of human papillomavirus and Epstein–Barr virus in male Chinese lichen sclerosus patients: a single center study

    Science.gov (United States)

    Zhang, Yumeng; Fu, Qiang; Zhang, Xiong

    2016-01-01

    This study aimed to investigate the presence of human papillomavirus and Epstein–Barr virus in male lichen sclerosus patients. We extracted DNA from formalin-fixed paraffin-embedded foreskin tissue blocks of 47 male LS patients and 30 healthy men and performed real-time PCR test to detect HPV and EBV. None of the 47 LS patients and 30 healthy men had detectable HPV infection. EBV was detected in 18 LS patients (38.3%) and four healthy men (13.3%), the difference is significant (P < 0.05). Tissue blocks with significant inflammatory reaction tend to have higher EBV load. HPV has no significant relationship with LS. Male LS patients have higher EBV infection rate, but the role of EBV in the pathogenesis of LS needs further investigate. PMID:26289401

  19. Measurement of Some Physiological and Biochemical Indexes of the Antisense Fragment of CYP86MF Gene Transgenic Male Sterile Plantlets in Chinese Cabbage-Pak-Choi

    Institute of Scientific and Technical Information of China (English)

    YU Xiao-lin; CAO Jia-shu; DONG De-kun

    2003-01-01

    In order to study the mechanism of the transgenic male sterility induced by the antisense fragment of gene CYP86MF, some physiological and biochemical indexes were compared between the transgenic plantlets of Chinese cabbage-pak-choi (Brassica campestris L. ssp. chinensis Makino) and their controls.Results showed that there was significant difference between content of the endogenous hormones in leaves and floral buds. GA3 contents in leaves of the transgenic plantlets of B. campestris L. ssp. chinensis Makino cv.Shanghai-qing and cv. Youqing were reduced by 31.72 and 46.88% respectively as compared with those of their controls, and GA3 contents in floral buds of them were reduced by 62.92 and 80.57 % respectively. In addition, ZT contents in leaves of cv. Shanghai-qing and cv. Youqing were reduced by 11.81 and 181.20%respectively as compared with those of their controls and those in floral buds were reduced by 105.94 and 128.75% respectively. But, ABA content in transgenic plantlets was significantly higher than that in nontransgenic plantlets. However, differences among respiratory rate and cyanide-resistant respiratory rate, the photosynthesic rate and the content of total flavones in floral buds were not significant. In this study, the results indicated that the gene CYP86MF might be one of the key functional genes to control fertility of Chinese cabbage.

  20. The characterisation of sexual behaviour in Chinese male university students who have sex with other men: A cross-sectional study

    Directory of Open Access Journals (Sweden)

    Zhang Dandan

    2008-07-01

    Full Text Available Abstract Background The risks for Chinese male university students who have sex with other men (MSM have not been compared with those for non-MSM students. This information is important for the development of targeted HIV prevention programmes for this population. Methods Sexually active MSM and non-MSM students were compared for demographic characteristics, sexual behaviour, and related psychosocial variables using bivariate analyses. The data were a subset drawn from a large-scale cross-sectional questionnaire survey of sexually active male students conducted at two universities in a large city in Zhejiang Province, China, in 2003. Results Of 1824 sexually active male students, 68 (3.7% reported having had sex with a man at least once; 33.8% of these 68 men had also had female partners. Compared with non-MSM students, MSM students were 3–6.5 times more likely to have had sexual encounters with casual or commercial sex partners and were three times less likely to have protected sex in the past year or during their lifetime. They were three to five times more likely to have had multiple partners and 15 times more likely to have had a sexually transmitted disease (STD. In addition, the MSM students knew half as much about HIV and had less condom-decision than did non-MSM students and were two times more accepting of commercial sex. However, the MSM students were twice as aware of the risks for HIV infection. Conclusion MSM composed 3–4% of the male sexually active university student population studied and was found to be at greater risk than non-MSM students for STD/HIV infection. There is an urgent need for STD/HIV programmes in university health services that take into consideration the sexuality and psychosocial issues of MSM students.

  1. Novel FGFR1 and KISS1R Mutations in Chinese Kallmann Syndrome Males with Cleft Lip/Palate

    Science.gov (United States)

    Xu, Hao; Niu, Yonghua; Wang, Tao; Liu, Simin; Xu, Hua; Wang, Shaogang; Liu, Jihong; Ye, Zhangqun

    2015-01-01

    Kallmann syndrome (KS) is characterized by isolated hypogonadotropic hypogonadism (IHH) with anosmia and is sometimes associated with cleft lip/palate (CLP). In order to describe the clinical features, genetic etiology, and treatment outcome of KS males with CLP, we performed genetic screening for 15 known causal IHH genes (KAL1, FGFR1, NELF, FGF8, CHD7, WDR11, SEMA3A, KISS1R, KISS1, PROKR2, PROK2, TAC3, TACR3, GNRH1, and GNRHR) in four KS with CLP patients and six IHH patients without CLP. Two novel heterozygous missense mutations in FGFR1, (NM_001174066): c.776G>A (p.G259E) and (NM_001174066): c.358C>T (p.R120C), were identified in a 23-year-old KS male with cleft lip and an 18-year-old KS patient with cleft lip and palate, dental agenesis, and high arched palate, respectively. These two mutations were not presented in their healthy parents and 200 normal controls. One novel heterozygous missense mutation in KISS1R, (NM_032551): c.587C>A (p.P196H), was identified in an 18-year-old KS male with cleft lip and dental agenesis who developed sperm after being treated with gonadotropin. This mutation was also presented in his healthy father and grandfather. These results have implications for the diagnosis, genetic counseling, and treatment of KS and CLP males with mutations in FGFR1 gene. PMID:26199944

  2. Motivations of German Hospice Volunteers: How Do They Compare to Nonhospice Volunteers and US Hospice Volunteers?

    Science.gov (United States)

    Stelzer, Eva-Maria; Lang, Frieder R

    2016-03-01

    We examined reasons of volunteering for hospice and nonhospice organizations in a study with 125 volunteers (22-93 years) from the United States and Germany. Motives of US and German hospice volunteers revealed similarities and few differences. Hospice volunteers are involved because they seek to help others, seek new learning experiences, seek social contacts, or seek personal growth. The US hospice volunteers reported motives related to altruistic concerns, enhancement, and social influence as more influential, while German hospice volunteers rated career expectations as being more important. Comparison of German hospice with nonhospice volunteers revealed stronger differences: German hospice volunteers scored higher on altruistic motives, while German nonhospice volunteers yielded higher scores on self-serving motives. Findings contribute to improved understanding of volunteering motivation and of activating or retaining hospice volunteers. PMID:25422517

  3. CHRNA3 rs6495308 Genotype as an Effect Modifier of the Association between Daily Cigarette Consumption and Hypertension in Chinese Male Smokers

    Directory of Open Access Journals (Sweden)

    Xiao-Ying Wu

    2015-04-01

    Full Text Available Cigarette smoking is an important risk factor for hypertension. However, the effects on hypertension of the interaction between smoking and the genotype of the nicotinic acetylcholine receptor gene are unclear. The purpose of this study is to determine whether the CHRNA3 rs6495308 genotype affects the association between daily cigarette consumption and hypertension. We recruited 947 male smokers in southern China and used a questionnaire administered in face to face interviews to obtain information on their socio-demographic characteristics and smoking behavior. Blood samples were collected to test for CHRNA3 rs6495308 genotype variations. Three blood-pressure measurements were taken for each participant, and the average values recorded. We found that, compared with light smoking (<15 cigarettes per day, heavy smoking (≥15 cigarettes per day yielded a greater risk of hypertension. We also observed that the interaction between daily cigarette consumption and the CHRNA3 rs6495308 genotype may affect hypertension. Heavy smokers with the homozygous mutant CHRNA3 rs6495308 genotype exhibited a significantly greater risk of hypertension than light smokers with wild-type CHRNA3 rs6495308 genotypes. The positive interaction between heavy smoking and the homozygous mutant CHRNA3 rs6495308 genotype was found to affect the likelihood of hypertension in Chinese male smokers.

  4. Differential Expression Analysis of Genic Male Sterility A/B Lines in Chinese Cabbage-Pak-Choi(Brassica Campestris ssp. chinensis Makino)

    Institute of Scientific and Technical Information of China (English)

    WANG Yong-qin; CAO Jia-shu; FU Qing-gong; YU Xiao-lin; YE Wan-zhi; XIANG Xun

    2003-01-01

    To determine differential expression of genic male sterility A/B lines in Chinese cabbage-pakchoi (Brassica campestris ssp. chinensis Makino var. communis Teen et Lee), we used the RNA fingerprinting technique, cDNA-AFLP analysis, in different developmental stages and different tissues. While no obvious differential expressions were observed in rosette leaves, florescence leaves, and scapes, some differential expressions were found in alabstrums of A/B lines and among leaves, scapes and alabstrums. We analyzed the alabstrums collected in different developmental stages with 10 primer combinations. We got a unique band between middle size alabstrums and large alabstrums in B line in one of the ten pair primers, and in another one pair, one band reflecting a higher gene-expression level in A line than that in B line was obtained. No unique bands were found with the other primer combinations. The bands reflecting different gene-expression level were confirmed by Northern hybridization. The results indicated that cDNA-AFLP was a suitable tool for studying differential expression of genic male sterility in plants. SDS-polyacrylamide gel electrophoresis patterns of soluble proteins further verified the difference in A/B lines.

  5. Er-Xian Decoction, a traditional Chinese herbal formula, intervening early in hypothalamic-pituitary axis of male rats with delayed puberty

    Directory of Open Access Journals (Sweden)

    Zheng Zhu

    2014-01-01

    Full Text Available Background: Er-Xian Decoction (EXD is one of the traditional Chinese medicine (TCM with unique effect on osteoporosis, menopausal syndrome and delayed puberty in China for many years. Objective: We aim to evaluate the potential activity of starting hypothalamic-pituitary-testicular (HPT axis of male rats with delayed puberty. Materials and Methods : Delayed puberty model of male Sprague-Dawley (SD rats were established with soy isoflavones (90 mg·kg -1 and were treated by EXD extract at doses of 5, 10 g·kg -1 or Testosterone undecanoate (TU for 8 weeks. Body weight, body length, testis weight, T, E 2 and luteinizing hormone (LH in serum, gonadotropin releasing hormone (GnRH in hypothalamus, follicle stimulating hormone (FSH and LH in pituitary gland were determined by ELISA. Immunohistochemistry was used to detect LH in pituitary gland . Results: Soy isoflavones could significantly decrease body weight, body length, testicular organ coefficient T in serum, GnRH in hypothalamus, FSH and LH in pituitary gland. Both of EXD and TU could improve the condition. E 2 and LH in serum of all groups were non-significance of difference (P > 0.05. The immunohistochemical results were well consistent with LH in pituitary gland. Conclusion: The results of the present research indicate that EXD extract is effective to start the HPT axis in puberty and can significantly improve sexual developmental inhibition caused by soy isoflavones.

  6. Call for volunteers

    CERN Multimedia

    2008-01-01

    CERN is calling for volunteers from all members of the Laboratory for organizing the two exceptional Open days.CERN is calling for volunteers from all members of the Laboratory’s personnel to help with the organisation of these two exceptional Open Days, for the visits of CERN personnel and their families on the Saturday and above all for the major public Open Day on the Sunday. As for the 50th anniversary in 2004, the success of the Open Days will depend on a large number of volunteers. All those working for CERN as well as retired members of the personnel can contribute to making this event a success. Many guides will be needed at the LHC points, for the activities at the surface and to man the reception and information points. The aim of these major Open Days is to give the local populations the opportunity to discover the fruits of almost 20 years of work carried out at CERN. We are hoping for some 2000 volunteers for the two Open Days, on the Saturday from 9 a.m. to ...

  7. Together we have fun: native-place networks and sexual risk behaviours among Chinese male rural-urban migrants.

    Science.gov (United States)

    Yang, Xiaozhao Yousef; Kelly, Brian C; Yang, Tingzhong

    2016-05-01

    Some scholars argue that the maintenance of social networks contributes to the lower prevalence of deviant behaviours and fewer adverse health effects among migrants. But others suggest that if migrants are embedded in homogeneous networks, such networks may enable the formation of a deviant subculture that promotes risk taking. Facing this dilemma, the present study investigates how native-place networks influence sexual risk behaviours (SRBs), specifically the pursuit of commercial sex and condomless sex with sex workers, for male rural-urban migrants. Using a multi-stage sample of 1,591 male rural-urban migrants from two major migrant-influx cities within China, we assessed migrants' general friend network ties and native place networks (townsmen in migrants' local networks) and tested their associations with SRBs. Multiple logistic regression analyses indicate that native-place network ties are associated with paying for sex (OR = 1.33, p youtube.com/watch?v=3Wg20I6j8XQ. PMID:26582759

  8. Volunteer bias in sex research :effects of variable stimuli content and intrusiveness of measurement

    OpenAIRE

    Lane, Mary Kathleen

    1988-01-01

    Previous studies of volunteer bias in sex research found that volunteers for such studies differed from nonâ volunteers in terms of reporting increased heterosexual experience; more liberal attitudes toward sex; increased exposure to commercialized erotica; and an increase in sexual trauma. The object of this study was to investigate the effects that varying the stimuli content (i.e. heterosexual vs gay male vs lesbian) of films used in sexual arousal studies would have on volunteer rate an...

  9. VOLUNTEERING IN EASTERN EUROPEAN COUNTRIES

    OpenAIRE

    Emilian M. DOBRESCU

    2011-01-01

    Around 100 million people residing in EU countries, so about 24 percent of the EU participate in volunteer activities. About 20 million volunteers live in countries from Eastern Europe, so they represent about 20 percent of the volunteers from EU countries. It is widely recognized the social and cultural dimension of volunteering, reflected in employment and social inclusion, education and training, active citizenship and mass sport. But the economic dimension of volunteerism, especially duri...

  10. Glycemic index and glycemic load of selected Chinese traditional foods

    Institute of Scientific and Technical Information of China (English)

    Stephen; Heung-sang; Wong

    2010-01-01

    AIM:To determine the glycemic index(GI)and glycemic load(GL)values of Chinese traditional foods in Hong Kong.METHODS:Fifteen healthy subjects(8 males and 7 females)volunteered to consume either glucose or one of 23 test foods after 10-14 h overnight fast.The blood glucose concentrations were analyzed immediately before,15,30,45,60,90 and 120 min after food consumption using capillary blood samples.The GI value of each test food was calculated by expressing the incremental area under the blood glucose respon...

  11. Enhancing Leadership Skills in Volunteers

    Science.gov (United States)

    Lockett, Landry L.; Boyd, Barry

    2012-01-01

    This article describes how professionals leading volunteers can purposefully work toward developing the "leadership identity" of individual volunteers. These concepts and the application of them are presented in the context of Cooperative Extension volunteer groups. Specific methods of developing the leadership identity and capacity of individual…

  12. Evaluation of drug-drug interaction between henagliflozin, a novel sodium-glucose co-transporter 2 inhibitor, and metformin in healthy Chinese males.

    Science.gov (United States)

    Wang, Liupeng; Wu, Chunyong; Shen, Lu; Liu, Haiyan; Chen, Ying; Liu, Fang; Wang, Youqun; Yang, Jin

    2016-08-01

    1. Henagliflozin is a novel sodium-glucose transporter 2 inhibitor and presents a complementary therapy to metformin for patients with T2DM due to its insulin-independent mechanism of action. This study evaluated the potential pharmacokinetic drug-drug interaction between henagliflozin and metformin in healthy Chinese male subjects. 2. In open-label, single-center, single-arm, two-period, three-treatment self-control study, 12 subjects received 25 mg henagliflozin, 1000 mg metformin or the combination. Lack of PK interaction was defined as the ratio of geometric means and 90% confidence interval (CI) for combination: monotherapy being within the range of 0.80-1.25. 3. Co-administration of henagliflozin with metformin had no effect on henagliflozin area under the plasma concentration-time curve (AUC0-24) (GRM: 1.08; CI: 1.05, 1.10) and peak plasma concentration (Cmax) (GRM: 0.99; CI: 0.92, 1.07). Reciprocally, co-administration of metformin with henagliflozin had no clinically significant on metformin AUC0-24 (GRM: 1.09, CI: 1.02, 1.16) although there was an 11% increase in metformin Cmax (GRM 1.12; CI 1.02, 1.23). All monotherapies and combination therapy were well tolerated. 4. Henagliflozin can be co-administered with metformin without dose adjustment of either drug. PMID:26608671

  13. Active oxygen metabolism in the floral buds and leaves of the new cytoplasm male sterile(CMS)line and its maintainer line of non-heading Chinese cabbage

    Institute of Scientific and Technical Information of China (English)

    YUAN Jianyu; HOU Xilin; ZHANG Changwei; YE Fan

    2007-01-01

    The cytoplasm male sterile(CMS)line and its maintainer line of the newly-bred non-heading Chinese cabbage were taken as experimental materials.The production rate of superoxide anion radical(O2-),contents of malondialdehyde(MDA)and hydrogen peroxide(H2O2),and the activities of superoxide dismutase(SOD),peroxidase(POD),catalase(CAT)as well as ascorbate peroxidase(APX)were determined in buds of different developmental stages and leaves during vegetative and florescence stages.As showed by the results,there were higher levels of MDA and H2O2 contents,higher 02- production rate and higher activities of SOD,POD,and CAT in the buds of the CMS lines than that in the buds of the fertile lines,while the APX activity was different from the other three enzymes above.There were differences in activities of protective enzymes in leaves but no significant differences in MDA contents and O2- production rate,which showed that the differences in metabolism of active oxygen between CMS and its maintainer were mainly apparent in reproductive organs.

  14. The European GWAS-identified risk SNP rs457717 within IQGAP2 is not associated with age-related hearing impairment in Han male Chinese population.

    Science.gov (United States)

    Luo, Huajie; Wu, Hao; Shen, Hailian; Chen, Haifeng; Yang, Tao; Huang, Zhiwu; Jin, Xiaojie; Pang, Xiuhong; Li, Lei; Hu, Xianting; Jiang, Xuemei; Fan, Zhuping; Li, Jiping

    2016-07-01

    This study aimed to test the association between the European GWAS-identified risk IQGAP2 SNP rs457717 (A>G) and age-related hearing impairment (ARHI) in a Han male Chinese (HMC) population. A total of 2420 HMC subjects were divided into two groups [group 70+: >70 years (n = 1306), and group 70-: ≤70 years (n = 1114)]. The participants were categorised into case and control groups according to Z high scores for group 70- and the severity of hearing loss and different audiogram shapes identified by K-means cluster analysis for group 70+. The IQGAP2 tagSNP rs457717 was genotyped in accordance with the different ARHI phenotypes. The genotype distributions of IQGAP2 (AA/AG/GG) were not significantly different between the case and control groups (P = 0.613 for group 70-; P = 0.602 for group 70+). Compared with genotype AA, the ORs of genotypes AG and GG for ARHI were not significantly different following adjustment for other environmental risk factors. We demonstrated that the IQGAP2 TagSNP rs457717 (A/G) was not associated with ARHI in HMC individuals. PMID:26187738

  15. Breeding and Utilization of the Genetic Male Sterile Line in Milk Chinese Cabbage%奶白菜核基因雄性不育系的选育与利用

    Institute of Scientific and Technical Information of China (English)

    徐巍; 冯辉

    2013-01-01

    In order to resolve the problem that cross breeding and production of hybrid in milk Chinese cabbage. According to the hypothesis of multiple allele inherited genetic male sterile, A genetic male sterile line of Chinese cabbage with green stipe 00S107 was used as a source of male sterility,and methods of continuous backcross-ing and identifying of the genotypes were applied to transfer the male sterile line of milk Chinese cabbage. Hybridized combinations were obtained by the male sterile line as female parent cross with excellent self-line and we analysed the hybrid vigor. A new genetic male sterile line GMS3 with 100% male sterile plants and 100% male sterility was obtained. Two excellent hybridized combinations GMS3 × B1 ,GMS3×B2 were selected, whieh is uniform and superior to CK in yield. Directional transfer model which transfer sterile gene and horticultural characters at the same time resolved the puzzle that breeding and utilization of the genetic male sterile line in milk Chinese cabbage.%为解决奶白菜杂交种生产中的杂交制种手段问题,配制优良杂交种.以核不育“复等位基因遗传”假说为指导,以青梗白菜核基因雄性不育系00S107作不育源,采用连续回交转育同时测交鉴定基因型的方法,定向转育奶白菜核基因雄性不育系.并利用转育成的不育系与奶白菜优良自交系配制杂交组合,进行了杂种优势分析.选育出园艺学性状与目标品系相似,具有100%不育株率和不育度的奶白菜核基因雄性不育系GMS3,筛选出2个产量高、整齐度高的优异杂交组合GMS3×B1、GMS3×B2.定向转育模式兼顾了不育基因和园艺学性状的转育,解决了奶白菜核不育系转育和利用的难题.

  16. Volunteers in the Heat

    Institute of Scientific and Technical Information of China (English)

    Li Zhijian

    2011-01-01

    BORN in a quiet city in south China,He Yulan's childhood memo-ries were right out of a traditional Chinese ink and wash painting:leaves swinging in the breeze,a crystal-clear river running through the town.Then last November she moved to Cameroon.

  17. Making room for volunteers

    DEFF Research Database (Denmark)

    Nielsen, Rasmus Kleis

    2012-01-01

    If campaigns do not accommodate this view, all but a hard core of regulars and fired-up partisans will drift away, leaving it for staffers and hired hands to do all the hard work of identifying voters, canvassing people by foot and by phone, and turning out the vote. [...] ironically, a campaign...... that is singleminded in its instrumental pursuit of victory can thus be less effective than one that is more accommodating- a campaign that makes room for volunteers by accepting that, unlike staffers, they come to politics with a different perspective and conception of what is and ought to be going on....

  18. Volunteer Team Management

    OpenAIRE

    Monych, Maria

    2015-01-01

    This thesis looked into volunteer team management in a project in AIESEC in Finland through the action research method. AIESEC in Finland is a non-profit non-government organization with a purpose of “peace and fulfilment of humankinds potential” through development of the youth’s future leadership. AIESEC was not a commissioning party; the project was the basis for the thesis without the supervision of the company. The thesis is based on a project that the author was in charge of, in ...

  19. Micro-volunteering and leadership in CPH Volunteers

    OpenAIRE

    Yankova, Kalina Boyanova; Gottlieb, Mikkel; Raya Prasai, Manuka; Shrestha Sainju, Romisha

    2016-01-01

    In recent years, there have been tremendous changes in the voluntary world. The technological revolution has opened up new possibilities for volunteering, both in terms of how people find opportunities, and how people actually carry out their volunteer activities. While these new types of volunteering are rapidly spreading around the world, it seems as if they have not yet received a solid foothold in Denmark, a country otherwise well known for their strong voluntary tradition. In addition, t...

  20. Volunteers in the Heat

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Teaehing Chinese in Cameroon BORN in a quiet city stu- in south China,He Yulove lan’s childhood memo-Peng ries were right out of-five a traditional Chinesenese ink and wash painting:une, leaves swinging in the!" breeze,a crystal-clear river running through the town.Then last Noson’s vember she moved to d for Cameroon,the

  1. 中国不同性别亚健康人群差异分析%Sub-health status in male and female Chinese populations

    Institute of Scientific and Technical Information of China (English)

    王秀; 何裕民

    2012-01-01

    Objective To explore different sub-health status between populations of different gender. Methods A cross-sectional study was conducted to analyze sub-health status of 13 439 people in 8 provinces in China. Results Sub-health status of male was much more expressed in sexual life( male:5. 22 ± 1.06,femal:4.92 ±0. 96), while female was much more expressed in physical and psychological symptoms ( physical symptoms score for male: 104. S3 ± 20.47, for female; 110.27 ±20.90:psychological score for male:53.63 ±8.04,for female:55. 89 ±7. 88;P0.05). For somatic symptoms, the men had a hypo-immunity and were susceptible to cold or with a longer period of the disease compared to the woman (P < 0.001). While women felt tired easily and frequently had digestive problem, poor sleep, autonomic nervous disorders, allergy, aging apperance, a variety of pain or discomfort, constipation, and frequent drug usage (P < 0.001). In psychological symptoms, women showed more depression, anxiety problem,memory loss,and severe stress than men(P<0.001 for all). There was a significant difference in sexual satisfaction score between the men and the women with sub-health (P <0.01) and the men were more likely to worry about sexuality than women (P < 0. 01). Conclusion The symptoms of sub-health are different between men and-women in Chinese population.%目的 探讨不同性别亚健康状态人群症状表现差异.方法 采用流行病学横断面调查方法对中国8个省市13 439名各类人群进行亚健康状态调查分析.结果 男、女性亚健康症状性生活得分分别为(5.22±1.06)、(4.92±0.96)分,躯体症状分别为(104.53±20.47)、(110.27±20.90),心理方面分别为(53.63±8.04)、(55.89±7.88)分,差异均有统计学意义(P<0.01);社会适应性方面差异无统计学意义(P>0.05);在躯体症状方面,男性免疫力低下,易患有感冒或感冒不易痊愈;与男性比较,女性易感到疲劳,消化系统不适多见,睡眠差,多有植

  2. Social media and community volunteering

    OpenAIRE

    Gulyás, A

    2015-01-01

    This seed project aimed to explore to what extent the transformative potentials of digital technologies, in particular social media, are being realised in relation to community volunteering. The project was funded by the Communities and Culture Network+ and Canterbury and Herne Bay Volunteer Centre was a project partner. The research explored how small non-profit organisations in the case study area of Canterbury district used social media for volunteering as well as how they have adopted the...

  3. Wasted resources volunteers and disasters

    OpenAIRE

    Souza, Andrew A.

    2009-01-01

    Approved for public release, distribution unlimited In the aftermath of the Oklahoma City bombing, a reported 12,000 volunteers arrived to help. Immediately after the 9/11 attacks, an estimated 30,000 volunteers converged on ground zero and the Pentagon. As the weather cleared following Hurricane Katrina, over 60,000 volunteers descended upon Lousiana, Alabama, Texas and Mississippi. These well-intentioned citizens were both a blessing and a curse. While offering assistance, they also ...

  4. Inhibitory effects of intravenous lansoprazole 30 mg and pantoprazole 40 mg twice daily on intragastric acidity in healthy Chinese volunteers: A randomized, open-labeled, two-way crossover study

    Science.gov (United States)

    Zhan, Xian-Bao; Guo, Xiao-Rong; Li, Zhao-Shen; Gong, Yan-Fang; Gao, Jun; Liao, Zhuan; Li, Zhen; Gao, Shen; Huang, Ling; Liu, Pei

    2012-01-01

    Summary Background Until now there has been no study that directly compares the effect of lansoprazole and pantoprazole administered intravenously on intragastric acidity. The aim of this study is to compare the effect of lansoprazole (30 mg) and pantoprazole (40 mg) administered intravenously on gastric acidity. Material/Methods Helicobacter pylori-negative healthy volunteers were recruited in this open-label, randomized, two-way crossover, single centre study. Lansoprazole at 30 mg or pantoprazole at 40 mg was intravenously administered twice daily for 5 consecutive days with at least a 14-day washout interval. Twenty-four-hour intragastric pH was continuously monitored on days 1 and 5 of each dosing period. Results Twenty-five volunteers completed the 2 dosing periods. The mean intragastric pH values were higher in subjects treated with lansoprazole than those with pantoprazole on both day 1 (6.41±0.14 vs. 5.49±0.13, P=0.0003) and day 5 (7.09±0.07 vs. 6.64±0.07, P=0.0002). Significantly higher percentages of time with intragastric pH >4 and pH >6 were found in the subjects treated with lansoprazole than those with pantoprazole on day 1 (pH >4, 87.12±4.55% vs. 62.28±4.15%, P=0.0012; pH >6, 62.12±4.12% vs. 47.25±3.76%, P=0.0216) and pH >6 on day 5 (76.79±3.77% vs. 58.20±3.77%, P=0.0025). Conclusions Intravenous lansoprazole produces a longer and more potent inhibitory effect on intragastric acidity than does intravenous pantoprazole. PMID:22293876

  5. Volunteering for charity: pride, respect, and the commitment of volunteers.

    Science.gov (United States)

    Boezeman, Edwin J; Ellemers, Naomi

    2007-05-01

    This study builds upon and extends the social-identity-based model of cooperation with the organization (T. R. Tyler, 1999; T. R. Tyler & S. L. Blader, 2000) to examine commitment and cooperative intent among fundraising volunteers. In Study 1, structural equation modeling indicated that pride and respect related to the intent to remain a volunteer with an organization, and that this relation was mediated primarily by normative organizational commitment. In Study 2, structural equation modeling indicated that the perceived importance of volunteer work was related to pride, that perceived organizational support related to the experience of respect, and that pride and respect mediated the relation between perceived importance and support on the one hand and organizational commitment on the other. Overall, the results suggest that volunteer organizations may do well to implement pride and respect in their volunteer policy, for instance to address the reliability problem (J. L. Pearce, 1993). PMID:17484556

  6. Pharmacokinetics of Oral Taurine in Healthy Volunteers

    OpenAIRE

    Mohammadreza Ghandforoush-Sattari; Siminozar Mashayekhi; Krishna, Channarayapatna V.; Thompson, John P.; Routledge, Philipp A.

    2010-01-01

    Taurine, a sulfur-containing amino acid, is a normal constituent of the human diet. Little is known of the pharmacokinetics of taurine in man after oral administration. We studied the pharmacokinetics of 4 g taurine in eight healthy male volunteers (median age 27.5, range 22–45) following orally administration in the fasting state in the morning. Blood samples were taken at regular intervals and plasma taurine concentration was measured by a modified HPLC method. Data were subjected to noncom...

  7. The consideration of emotional intelligence abilities in event volunteers

    Directory of Open Access Journals (Sweden)

    Reza Andam

    2012-09-01

    Full Text Available The measurement of emotional intelligence abilities is one of the new subjects and important in human behavior studies. According to this matter, purpose of this research is consideration of emotional intelligence abilities in public sport events volunteers in 2011. For this purpose, Bradbury and Cruise's standard questionnaire was completed by present volunteers in event (n=80. The results indicated that 4 levels of emotional intelligence in volunteers are higher than expectational average significantly (p<0.01. Also, priority of emotional intelligence abilities indicated that self-awareness is first priority and social awareness, relationship management and self-management are second, third and fourth priorities in volunteers. Finally, in the basis of parameter, results stated that there is no difference between male and female volunteers emotional intelligence in first Olympia of public sport. According to results of present research and advantages of attention to emotional intelligence and human behavior in organizations, it recommended sport events managers to be more sensitive relative to human behavior abilities in human behavior abilities in human resource (volunteers under his management. At least, result of this meditation in student's sport is recruitment and development of motivated volunteers for continuous attendance in sport events.

  8. My Days as a Volunteer

    Institute of Scientific and Technical Information of China (English)

    顾晓玲; 杨梦倩; 许文侠; 陈丽敏; 陈丽琼; 陈昊; 李雯

    2009-01-01

    Volunteer, a word derived from Latin, carries the meaning of "will". A volunteer is someone who works for a community or for the benefit of environment. There are various forms of voluntary work including "serving food at the local homeless shelter,

  9. Managing Library Volunteers, Second Edition

    Science.gov (United States)

    Driggers, Preston; Dumas, Eileen

    2011-01-01

    Volunteers are essential to a successful library program--and at a time when deep budget cuts are the norm, there are many libraries that depend on the help of dedicated volunteers, who do everything from shelving books to covering the phones. Whether these are friends, trustees, or community members, managing them effectively is the key to…

  10. The Effective Use of Volunteers.

    Science.gov (United States)

    Nichols, Scott G.

    1980-01-01

    If volunteers are to be effective, they must perform needed tasks, have a clear job description, a sense of importance, a schedule for completion, and an understood term of office. Identifying, recruiting, and training fund-raising volunteers are discussed. Annual giving specialists are classified as leaders, personal solicitors, class agents,…

  11. Bioequivalence of metformin hydrochloride tablets in Chinese healthy volunteers%盐酸二甲双胍片在中国健康人体的生物等效性

    Institute of Scientific and Technical Information of China (English)

    邱相君; 孙永健; 刘涛; 刘心霞; 袁世英; 陈汇

    2012-01-01

    Objective To evaluate the bioequivalence of two domestic metformin hydrochloride tablets in healthy volunteers. Methods A single oral dose (1. 0 g of test and reference formulation) was given to 20 healthy volunteers in a randomized crossover study. The concentrations of metformin hydrochloride in plasma were determined by HPLC. The bio-availability and bioequivalence of two formulations were evaluated by DAS 2. 0 software, then the bioequivalence was judged. Results After a single dose, the pharmacokinetic parameters for tested and reference metformin hydrochloride were as follows: Cmax were (2. 83 ± 0. 53 ), (2.57±0.57) mg , L-1; Twere (1.55 ±0. 39) , (t. 63 ±0. 36) h; t1/2 were ( 3. 70 + 1. 76), (3. 36 ± 0. 72) h; AUC0_24 were (10. 20 ± 1. 95), (9. 71 ± 2. 56) mg · h · L-1, respectively. The 90% confidential interval of AUC0-24, AUC0-∞ and Cmax of test formulation were 99. 1% -114.6% , 99. 1% -113. 8% and 100.6% -110.4% , respectively. The relative bioavailability of test to reference formulation was (108. 3 ± 20. 5 ) % . Conclusion The test and reference metformra hydrochloride were bioequivalence.%目的 评价2种国产盐酸二甲双胍片(口服降糖药)在中国健康人体的生物等效性.方法 20名健康男性受试者随机交叉单剂量口服盐酸二甲双胍片试验药物和对照药物,各1.0 g.用高效液相色谱法测定血浆中盐酸二甲双胍的浓度,用DAS 2.0软件计算药代动力学参数,并对2种药物进行生物等效性评价.结果 试验药物和对照药物的主要药代动力学参数如下:Cmax为(2.83±0.53),(2.57±0.57) mg· L-1;Tmax为(1.55±0.39),(1.63±0.36)h;t1/2为(3.70±1.76),(3.36±D.72) h;AUC0-24为(10.20±1.95),(9.71±2.56) mg·h·L-1.AUC0-24、AUC0-∞、Cmax的90%可信区间分别为99.1% ~114.6%、99.1% ~ 113.8%和100.6%~110.4%.试验药物相对于对照药物的生物利用度F为(108.3±20.5)%.结论 试验药物和对照药物生物等效.

  12. Bioequivalence of paracetamol and dihydrocodeine tatrate capsules in Chinese healthy volunteers%氨酚双氢可待因胶囊在健康人体的生物等效性

    Institute of Scientific and Technical Information of China (English)

    邱相君; 王淑英; 刘涛; 袁世英; 刘心霞; 陈汇

    2011-01-01

    Objective To study the bioequivalence of paracetamol and dihydrocodeine tartrate capsules in healthy volunteers.Methods A single oral dose of tested and reference formulation were given to 20 healthy volunteers in a randomised crossover study.The concentrations of acetaminophen and dihydrocodeine in plasma were determined by HPLC, respectively.The pharmacokinetic parameters were calculated and the bioavailability and bioequivalence of acetaminophen and dihydrocodeine were evaluated by DAS program.Results After a single dose, the pharmacokinetic parameters for acetaminophen were as follows: Cmax were (9.06 ±2.05) and (9.15 ±2.50) mg· L-1; AUC0-14were (34.46 ±7.49) and (35.91 ±7.01) mg · h · L-1; AUC0-∞ were (35.66 ±7.86) and (37.24 ± 7.56) mg· h · L- 1 for tested and reference formulation, respectively.The relative bioavailability was (97.17 ± 19.09)%The pharmacokinetic parameters for dihydrocodeine were as follows:Cmax were (61.84 ±9.84) and (58.33 ±6.79) μg · L-1; AUC0-14 were (289.23 ±31.30) and (281.56 ±25.91) μg · h · L-1; AUC0-∞ were (304.83 ±32.95) and (298.45 ±29.15) μg · h · L-1 for tested and reference formulation, respectively.The relative bioavailability was ( 103.58 ± 15.09) %.Conclusion The results of the statistic analysis showed that the two formulations were bioequivalence.%目的 研究氨酚双氢可待因胶囊(解热镇痛药)在健康人体的生物等效性.方法 健康志愿者 20 名随机双交叉分别单剂量口服氨酚双氢可待因胶囊(试验制剂)和氨酚双氢可待因片(参比制剂);分别于服药后 14 h 内,多点抽取静脉血;用高效液相色谱法分别测定血浆中对乙酰氨基酚和双氢可待因的浓度;用 DAS 程序计算相对生物利用度并评价 2 种制剂生物等效性.结果 单剂量口服氨酚双氢可待因胶囊和片剂后,血浆中对乙酰氨基酚的 Cmax 分别为(9.06±2.05),(9.15±2.50)mg·L-1;AUC0-14分别为(34.46±7.49),(35.91±7.01)mg·h·L-1

  13. Studies on the pharmacokietics and relative biovailability of clarithromycin tablets in healthy Chinese volunteers%中国志愿者口服克拉霉素片剂的药代动力学与相对生物利用度研究

    Institute of Scientific and Technical Information of China (English)

    洪诤; 尹华熙; 洪思佳; 王浴生

    2003-01-01

    健康志愿者9名采用三交叉设计分别口服500mg国产西安制药厂克拉霉素片剂A,丽珠制药厂克拉霉素片剂B(250mg/片)及进口克拉霉素片(KLACID,250mg/片).克拉霉素的血药浓度用微生物法进行测定.这三种制剂血药药浓度-时间过程十分相似,符合开放二室模型.片剂A、B与KALCID的药动学参数如下:Tmax分别为(2.06±0.30)、(2.11±0.42)及(1.89±0.33)h;Cmax分别为(2.47±0.30)、(2.63±0.25)及(2.64±0.33)mg/L;AUC分别为(21.50±3.53)、(19.10±2.39)及(19.92±2.63)mg·h/L.以KLACD作为参考标准(生物利用度为100%),A、B片剂的相对生物利用度分别为107.9%与95.9%.本试验的药动学参数与文献报道日本志愿者相仿,但与西方志愿者相比存在很大差异,值得进一步研究.%The pharmacokinetics of domestic clarithromycin tablet A (Xian Pharmaceuticals,250mg/tab), B (Lizhu Pharmaceutical Factory, 250mg/tab), and Italy-made clarithromycin (KLACID,250mg/tab) were determined after triple cross over administration 500mg orally in 9 healthy Chinese volunteers. The serum drug concentrations were measured by microbiological assay. The serum drug course of tablet A, B and KLACID were very similar and could be best described by an open two compartment model.The main pharmacokinetics parameters of A, B and KLACID were as follows: Tmax= (2. 06±0. 30), (2. 11 ±0.42) and (1.89±0. 33)h; Cmax= (2.47±0. 30), (2.63±0. 25) and (2.64±0. 33)mg/L; AUC = (21.50±were 107.9% and 95.9% compared with KLACID (100%, as reference standard). The Cmax and AUC data presented here were twice higher than that of the western volunteers, but generally in agreement with that of the Japanese volunteers. Such a big difference between eastern and western volunteers were worthy to be investigated.

  14. Comparative study on 3-point shot rate of Chinese male basketball team in Beijing Olympic Games%北京奥运会中国男篮3分球命中率比较研究

    Institute of Scientific and Technical Information of China (English)

    刘光鼎

    2012-01-01

    By means of literature reviews,video observation,data statistics and comparative analysis,the article systematically summarizes the 3-point shot scores of Chinese male basketball team in the Man Basketball Match of the 29th Olympic Games,such as the scores of the whole team,the guards,the forwards,and the centers.The scores are compared and analyzed with those of the opponents.The aim of article is to find out the problems that lie in the development of the Chinese male basketball team.%采用文献资料法、录像观察法、数理统计法、比较分析法等对第29届奥运会男子篮球赛中国男篮的6场比赛中,中国男篮全队整体3分球得分;后卫3分球得分;前锋3分球得分;中锋3分球得分等进行全面系统地总结,并与对手的情况进行对比与分析,希望从中找出制约我国男子篮球队发展的问题.

  15. Perceived Multiple Intelligences among Male and Female Chinese Gifted Students in Hong Kong: The Structure of the Student Multiple Intelligences Profile

    Science.gov (United States)

    Chan, David W.

    2006-01-01

    This study examined the structure of perceived multiple intelligences of 1,464 Chinese gifted students using the Student Multiple Intelligences Profile. To evaluate whether perceived multiple intelligences could be applied adequately across boys and girls, a model hypothesizing different degrees of equivalence across the two gender groups was…

  16. Bioequivalence of citalopram in Chinese healthy volunteers%西酞普兰片在中国健康受试者的人体生物等效性研究

    Institute of Scientific and Technical Information of China (English)

    樊鹏利; 赵宁民; 张海峰; 马爱玲; 王漪檬

    2016-01-01

    目的:研究2种西酞普兰在健康受试者体内的生物等效性。方法18例健康男性受试者随机分组,自身对照,单次口服西酞普兰片20 mg,测定西酞普兰的血浆浓度,用DAS 2.1软件计算药代动力学参数,并进行方差分析和生物等效性评价。结果试验药与对照药的tmax分别为(4.14±3.10),(3.53±2.05) h;Cmax分别为(32.46±8.29),(34.55±7.05) ng・ mL-1;t1/2分别为(46.99±10.72),(42.91±8.23) h;AUC0-t 分别为(1379.83±301.72),(1455.61±349.93) ng・ h・ mL-1;试验药相对于对照药的生物利用度为(96.00±13.10)%。结论建立的分析方法灵敏、快速、准确,试验药与对照药有生物等效性。%Objective To study the pharmacokinetics and bioequivalence of two citalopram preparations .Methods Eighteen healthy volunteers were randomly divided into two groups , whose plasma concentrations of citalopram were determined by UPLC -MS/MS method after single oral dose of 20 mg.The pharmacokinetic parameters were calculated by DAS 2.1.Results The main pharmacokinetic parameters of citalopram in test and reference preparations were as follows:tmax were (4.14 ±3.10), (3.53 ±2.05 ) h; Cmax were ( 32.46 ±8.29 ), ( 34.55 ±7.05 ) ng・ mL-1;t1/2 were ( 46.99 ±10.72 ) , ( 42.91 ±8.23 ) h; AUC0-t were (1379.83 ±301.72), (1455.61 ±349.93) ng・ h・ mL-1, respective-ly.The relative bioavailability of citalopram was ( 96.00 ±13.10 )%. Conclusion The method was proved to be accurate , rapid and sensitive;citalopram in the test preparations was bioequivalent to the reference .

  17. Pharmacokinetics of oral and intravenous melatonin in healthy volunteers

    DEFF Research Database (Denmark)

    Andersen, Lars P H; Werner, Mads U; Rosenkilde, Mette M;

    2016-01-01

    BACKGROUND: The aim was to investigate the pharmacokinetics of oral and iv melatonin in healthy volunteers. METHODS: The study was performed as a cohort crossover study. The volunteers received either 10 mg oral melatonin or 10 mg intravenous melatonin on two separate study days. Blood samples were...... collected at different time points following oral administration and short iv infusion, respectively. Plasma melatonin concentrations were determined by RIA technique. Pharmacokinetic analyses were performed by "the method of residuals" and compartmental analysis. The pharmacokinetic variables: k a, t 1....../2 absorption, t max, C max, t 1/2 elimination, AUC 0-∞, and bioavailability were determined for oral melatonin. C max, t 1/2 elimination, V d, CL and AUC 0-∞ were determined for intravenous melatonin. RESULTS: Twelve male volunteers completed the study. Baseline melatonin plasma levels did not differ...

  18. Knowledge and Attitude of Iranian Red Crescent Society Volunteers in Dealing with Bioterrorist attacks

    Directory of Open Access Journals (Sweden)

    Seyed Ali Bahreini Moghadam

    2014-09-01

    Full Text Available Introduction: Bioterrorism is a worldwide problem and has been the focus of attention during recent decades. There is no precise information on the knowledge, attitude, and preparedness of Iranian Red Crescent volunteers in dealing with bioterrorism. Therefore, the present study aimed to evaluate the above-mentioned parameters in Mahabad Red Crescent Society volunteers. Methods: In this prospective cross-sectional study, the knowledge of 120 volunteers was evaluated and rated as poor, moderate, and good. In addition, attitude of the volunteers and preparedness of Mahabad Red Crescent Society was rated as inappropriate and appropriate using a questionnaire. Results: The mean age of volunteers was 32.0 ± 8.2 years (62.5% male. 2 (1.7% volunteers had good knowledge while 94 (78.3% had no knowledge regarding bioterrorist attack management. Only 1 (0.8%  volunteer had appropriate attitude and 6 (5.0% stated their preparedness for being sent out to the crisis zone. 116 volunteers (96.7% indicated that Mahabad Red Crescent Society has an inappropriate level of preparedness to encounter bioterrorist attacks. Conclusion: The findings of the present study showed poor knowledge and inappropriate attitude of Mahabad Red Crescent Society volunteers in encountering probable bioterrorist attacks. Furthermore, the Red Crescent Society of this town had an inappropriate level of preparedness in the field of bioterrorism from the viewpoint of the studied volunteers.

  19. Volunteers - how to motivate and lead them

    OpenAIRE

    Sajo, Elise

    2014-01-01

    The aim of this thesis is to study the leadership of volunteers and its specific characteristics. The motivation of volunteers is studied and also how the leadership of volunteers is implemented in some volunteer organisations operating in Finland. The thesis also presents basic theories in human motivation and leadership styles to help identify suitable methods for the leadership of volunteers. The thesis process was conducted during the spring of 2014 and consisted of two parts. The fir...

  20. Volunteers in the experience economy

    DEFF Research Database (Denmark)

    Gudiksen, Sune Klok

    2012-01-01

    they help in the product development but also because they are seen as a cheap resource. From an employee perspective you often hear that it creates a sense of fear for cuts or loss of professionalism, but can also be seen as a helpful resource and dynamic element in the organization. In the Experience...... down, gathered and discussed. The Questions addressed is how to enlist, motivate and reward volunteers a long the way and how to manage and guide volunteers. Furthermore what kind of special relationship does the volunteer have in the making of the experience design and in the experience of that design....... This paper combines theories from psychology about motivational factors, game theories about rewards, business model theory about crowdsourcing and crowdfunding, user and customer experience theory with 25 interviews with experienced industry experts limited to the cultural sector and with relation to...

  1. Imipramine decreases oesophageal pain perception in human male volunteers

    OpenAIRE

    Peghini, P; Katz, P.; Castell, D

    1998-01-01

    Background—Visceral hyperalgesia is a hallmark of functional gastrointestinal disorders. Antidepressants improve symptoms in these patients, although their mode of action is unclear. Antidepressant, anticholinergic, and analgesic mechanisms have been proposed. 
Aims—To investigate whether imipramine, which has a visceral analgesic effect, increases pain thresholds to experimental visceral pain. 
Methods—Visceral perception for first sensation and pain was measured with intraoes...

  2. 45 CFR 1217.6 - Roles of volunteers.

    Science.gov (United States)

    2010-10-01

    ... communication of VISTA policies to VISTA volunteers. (c) Encourage and develop VISTA volunteer leadership and... VISTA VOLUNTEER LEADER § 1217.6 Roles of volunteers. VISTA volunteer leaders may have the...

  3. Results of feeding trials of irradiated diets in human volunteers: Summary of the Chinese studies at the FAO/IAEA Seminar for Asia and the Pacific on the practical application of food irradiation, Shanghai, People's Republic of China, 7-11 April 1986

    International Nuclear Information System (INIS)

    Following extensive chemical analyses and animal experimentation, which have shown that irradiated foods are safe, the Chinese researchers have carried out 8 well controlled experiments involving human volunteers consuming irradiated foods for 7 to 15 weeks periods. There were 17 to 70 test subjects in each experiment, and the total number of subjects was 439. Each clinical test in all the experiments failed to discern any significant difference between the control groups and the test groups consuming irradiated foods. Seven of the eight experiments involved investigations of chromosomal aberrations in a total of 382 individuals. Some of these experiments included freshly irradiated wheat in the diet. No significant difference between the number of chromosomal aberrations in the control groups and the test groups could be discerned in any of the seven experiments, either when evaluated individually or when all seven were pooled together. When all the experiments were pooled together, the average number of polyploidy at the beginning of the tests, before the exposure to irradiated foods, was 0.22% and 0.36% for the control and experimental groups respectively and after the exposure to the irradiated foods the polyploidy was 0.29% and 0.26% in the control and in the experimental groups respectively. The standard deviation of the mean value, 0.28%, was 0.23%. The relative increase in polyploidy in the control group, 0.29%-0.22%=+0.07%, and the relative decrease in the polyploidy in the experimental group, 0.26%-0.36%=-0.10% is statistically insignificant. In separate experiments it was shown that irradiation significantly reduces carcinogenic nitrosamines found in many foods confirming similar observation at U.S. Army Natick Laboratories in the 70's. (author). 51 refs, 2 tabs

  4. Volunteered Geographic Information in Wikipedia

    Science.gov (United States)

    Hardy, Darren

    2010-01-01

    Volunteered geographic information (VGI) refers to the geographic subset of online user-generated content. Through Geobrowsers and online mapping services, which use geovisualization and Web technologies to share and produce VGI, a global digital commons of geographic information has emerged. A notable example is Wikipedia, an online collaborative…

  5. Bioequivalence assessment of amoxicillin by limited sampling strategy in Chinese healthy volunteers%LSS法估算中国健康志愿者口服阿莫西林的生物等效性

    Institute of Scientific and Technical Information of China (English)

    陈丽芳; 焦建杰; 张才丽; 娄建石

    2012-01-01

    Objective To develop limited sampling strategy ( LSS) for estimating bioequivalence of amoxicillin. Methods Twenty male healthy subjects were enrolled in this bioequivalence study. All subjects were divided into two groups randomly and administered orally reference and test formulation of 500 mg amoxicillin. The blood concentrations of amoxicillin were determined by the validated HPLC method. A multiple linear regression analysis was developed for estimating Cmax and AUC0_t using the amoxicillin concentration of the reference formulation to develop LSS models. The LSS models were internally validated by the Jackknife meth od. The models were also externally validated by bioequivalence assessment of the test amoxicillin formulation based on LSS derived Cmax and AUC0-t values, The results were compared with those obtained using traditional method. Results The results indicate: several models for these parameters estimation met the predefined criteria. Validation tests indicated that most informative sampling points C1, C3 and C1 ,C2,C4 provided accurate estimations of the parameters AUC0-1, ( prediction error < 1% , absolute percentage < 10% ) ,And C1 ,C1.5 and C1.5 ,C2,C6 provided accurate estimations of the parameters Cmax ( prediction error < 2% , absolute percentage < 9%) . The combination of C1.5, C2, C6 might be chosen as sampling hours for predicting AUC0-t, and Cmax according to requirement. It is according with classical assessment. Conclusion The bioequivalence assessment results showed that LSS models provided correct assessment of bio equivalence between two amoxicillin preparations. The method is accurant and can be considered desirable for amoxicil lin bioequivalence study.%目的 用有限采样法(LSS)估算口服阿莫西林的生物等效性.方法 20名健康志愿者口服阿莫西林参比药物和受试药物500 mg后采集若干时间点血浆样品,用高效液相色谱法测定阿莫西林血药浓度,用经典方法计算药代动力学参

  6. Engaged anthropology and corporate volunteering

    Directory of Open Access Journals (Sweden)

    Natália Blahová

    2015-12-01

    Full Text Available The aim of this paper is to present engaged anthropology and its methodological tools with a specific perspective of the research field and the position of the researcher with regard to research subjects. The study focuses on corporate volunteering as one of the forms of collaboration between the non-profit and the private sectors seeking solutions to social problems and community development. Volunteering projects contribute to the interlinking of the knowledge, skills, experience and resources of corporate employees and the representatives of the non-profit or the public sector. It is a part of the philanthropic strategy of companies which are willing to present themselves as entities responsible towards the environment in which they run their business, and towards their employees, partners and customers. Engaged anthropology can bring, through its methodological tools, a new perspective of corporate volunteering. Community-based participatory research on the process of knowledge creation includes all partners on an equal basis and identifies their unique contribution to problem solution and community development.

  7. An Experience with Volunteers in Continuing Education.

    Science.gov (United States)

    Pillsworth, W. J.

    1986-01-01

    Offers examples of the use of volunteers in recreation and adult education programs. Describes Fanshawe College's local community advisory committees for continuing education centers. Identifies conditions for using volunteers effectively. Reviews Edison College's Talent Banking system which involves volunteers as visiting lecturers, career…

  8. The Effects of Implementation Intentions on Volunteer Firefighter Exercise Behavior: A Randomized Controlled Study

    OpenAIRE

    Hammer, Rodney L.

    2010-01-01

    The current study used a randomized control design to determine if an implementation intention intervention based on the Health Action Process Approach would increase exercise behavior in volunteer firefighters. One hundred forty-seven male and female volunteer firefighters from nine fire departments participated. The treatment group received a survey that prompted them to create exercise implementation intentions by describing "where," "when," and "how" they will exercise, while the control ...

  9. Bioavalaibility and pharmacokinetic comparison of two formulations of metformin 850 mg tablets in healthy Colombian volunteers

    OpenAIRE

    Gloria Holguín; Fanny Cuesta; Rosendo Archbold; Margarita Restrepo; Sergio Parra; Lina Peña; Blanca Montoya; Juan Carlos Ríos; Victoria Eugenia Toro; Adriana Ruiz

    2011-01-01

    urpose: The aim of this study was to compare the bioavailability of two formulations of metformin 850 mg tablets: Glucophage® from Merck Santè laboratories (reference product) and Metformin from Winthrop Pharmaceuticals de Colombia SA (test product) in healthy Colombian volunteers. Methods: A random, double blind, two-period, two-week wash out period, crossover study was performed in 24 healthy male and female volunteers for a single 850-mg dose of metformin tablets administrated with 240 ml ...

  10. Effect of allopurinol, sulphasalazine, and vitamin C on aspirin induced gastroduodenal injury in human volunteers.

    OpenAIRE

    McAlindon, M E; Muller, A F; Filipowicz, B; Hawkey, C J

    1996-01-01

    BACKGROUND--The mechanisms of aspirin induced gastroduodenal injury are not fully understood. Aspirin induces the release of reactive oxygen metabolites in animal models, which may contribute to mucosal injury. AIMS--To investigate the effects of aspirin administered with placebo or antioxidants on gastric mucosal reactive oxygen metabolite release and gastroduodenal injury in human volunteers. SUBJECTS--Fourteen healthy volunteers participated in the study (seven male; mean age 27 years, ran...

  11. Observation on Microstructure of Male Abortion in Chinese Cabbage%大白菜雄性败育的显微结构观察

    Institute of Scientific and Technical Information of China (English)

    王福青; 李敏; 曲咏梅

    2001-01-01

    通过对核质互作型雄性不育系169A和核雄性不育两用系88_3的细胞形态解剖学观察表明,两个不育系在开花时雄性细胞均表现100%的败育,花药的表皮细胞均具有生活力,但败育形式、时期、特点各异。169A败育发生于孢原细胞前后,以孢原细胞退化,或转变成薄壁细胞为主要特点。88_3败育从小孢子母细胞至二核花粉粒皆有发生,高峰期在四分体前后(约占80%),小孢子母细胞不能进入减数分裂和不能完成减数分裂及小孢子不能正常发育是败育的主要形式,但败育特点均是败育一旦发生便是急剧而彻底的解体或凝集成一团。%The morphological anatomical characters of the anthers from nucleo-cytoplasmic interaction male sterile line 169A and genic male sterile line 88-3 were observed. The results showed that the epidermal cells of the anther had viability,while the male sex cell of the two sterile lines appeared 100% abortion at blooming date, however,their abortion form,duration and characters were different.The abortion of 169A occurred before to behind of the sporogonia,whose important characterization was that the sporogonia degenerated or transformed into the parenchyma cells. The abortion of 88-3 ocurred from the microspore mother cells to pollen grains of two-nucleus,while the high peak stage of abortion(80%) occurred before and after the tetrad phase. The main abortion forms of 88-3 were that the microspore mother cells were not able to enter meiosis process and to finish meiosis,and the microspores were not able to develop normally.The same abortion character of the two male sterile lines was that the microspore mother cells and microspores sharply and thoroughly disintegrated or aggregated when abortion occurred.

  12. The Awareness of Gender Care in Chinese Male Magazines%中国男性杂志中的性别关怀意识

    Institute of Scientific and Technical Information of China (English)

    陈宁

    2012-01-01

    近年来,以男性为明确服务受众的男性杂志正面临着前所未有的商业和文化机遇。在性别观照的广度和深度上此类杂志表现出快速生长期特有的两重性。杂志突破了传统文化对两性特质的规约,多样的生活方式和审美取向得到了尊重和肯定,充满个性色彩的男性媒介形象日益丰富;但是,性别窠臼仍表现出强大的现实干预力量:夸大男性的性能力、贬低女性的职业能力并将之物质化、迷恋暴力细节等现象普遍存在,模式化的性别形象塑造正成为男性杂志创新性发展的瓶颈。%In recent years, male magazine, whose audience is specifically men, is facing unprecedented economic and cul- tural opportunities in rapid growth period. This type of magazines shows particular duality in extent and depth in the growth period in the aspect of gender observation. The magazines break the stipulations on men in traditional culture. Living methods and aesthetic appreciation in diversity get respect and affirmation. The male media images full of individuality become more and more colorful. However, the set pattern of sex displays powerful intervention in reality, paying special attention to men potency and womenprofessional capacity and materializes it, and being infatuated with violent details. The stereotype shaping of men proves to be the bottleneck in the innovation development of male magazines.

  13. The Analysis on the Factors of Chinese Male Basketball Team's Becoming World Strong Team%影响中国男篮成为世界强队的因素分析

    Institute of Scientific and Technical Information of China (English)

    林晗

    2012-01-01

    By means of literature review,video observation,statistics,comparison and other research methods,we do analysis on the disparity between Chinese basketball team and the World Champion from the following four areas: line-up structure,offensive ability,defensive ability,physical fitness and quality.The results show that the main reasons of the disparity lies in the overall unbalanced strength of the Chinese Basketball team,the lack of core competence.Recommendation: Chinese Male Basketball Team should reinforce the back line,promote the balanced development of the three locations,emphasize on speed,strength and other outbreaks of quality training to improve the use of technology under the strong confrontation.Moreover it should strengthen the defense pre-sentence,select defensive position properly,use of peer to defend and increase defensive intensity.%采用文献资料、录像观察、数理统计、比较等研究方法,从阵容结构、进攻能力、防守能力、体能与素质四个方面,对中国男篮与世界强队的差距进行分析。研究结果表明:中国男篮整体实力不均衡;进攻上投篮次数不足,命中率偏低,快攻得分与二次进攻得分较少;防守上抢断球能力偏弱,全场紧逼运用较少,防守强度不对等,是影响中国男篮成为世界强队的主要原因。建议:中国男篮应优先补强后卫线,促进中、前、后三位置的均衡发展;加强防守预判,积极利用同伴协防;重视速度、力量等爆发素质训练,提高强对抗下运用技术的能力。

  14. Association of L-FABP T94A and MTP I128T polymorphisms with hyperlipidemia in Chinese subjects.

    Science.gov (United States)

    Tian, Yingying; Li, Hui; Wang, Shanbo; Yan, Jin; Chen, Zhiheng; Li, Zhenyu; Feng, Han; Zhou, Honghao; Ouyang, Dongsheng

    2015-03-01

    The purpose of this study was to evaluate the relation between the L-FABP T94A and MTP I128T polymorphisms and hyperlipidemia in Chinese subjects. We recruited 390 volunteers: 201 hyperlipidemic and 189 healthy volunteers. The L-FABP T94A and MTP I128T polymorphisms were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Anthropometry, lipid profile, and liver function of the subjects were determined. We observed that male carriers of the L-FABP A94 allele had significantly higher body weight (P = 0.012), higher body mass index (BMI) (P = 0.014), and higher plasma triacylglycerol levels (TAG) (P = 0.033) and lower ratios of high-density lipoprotein cholesterol (HDL-C) to total cholesterol (TC) (P = 0.008) than T94 homozygotes. The MTP T128 allele was associated with significantly lower serum TC (P L-FABP T94A polymorphisms can affect serum lipid levels in the Chinese population. The MTP T128 allele offers protection against hyperlipidemia in the Chinese population. PMID:25663234

  15. 20 CFR 10.730 - What are the conditions of coverage for Peace Corps volunteers and volunteer leaders injured...

    Science.gov (United States)

    2010-04-01

    ... Corps volunteers and volunteer leaders injured while serving outside the United States? 10.730 Section... Corps volunteers and volunteer leaders injured while serving outside the United States? (a) Any injury sustained by a volunteer or volunteer leader while he or she is located abroad shall be presumed to...

  16. Motivations of Young Volunteers in Special Events

    OpenAIRE

    2008-01-01

    Volunteers are considered one of the main pillars of the special events. Motivations of volunteers have received a great attention from many organizations as they proved to be of a great value for human resources. Volunteering in special events bring different people together no matter what are their ethnics, origins, religion and economic standards. It also creates a sense of social harmony. The main issue of this research is to identify the motivations, needs and attitudes of young voluntee...

  17. Pain perception in healthy volunteers

    DEFF Research Database (Denmark)

    Janum, Susanne; Nielsen, Signe T; Werner, Mads U;

    2016-01-01

    We aimed to study the relationship between pain perception and cytokine release during systemic inflammation. We present a randomized crossover trial in healthy volunteers (n = 17) in 37 individual trials. Systemic inflammation was induced by an i.v. bolus of Escherichia coli LPS (2 ng/kg) on two...... separate trial days, with or without a nicotine patch applied 10 h previously. Pain perception at baseline, and 2 and 6 h after LPS was assessed by pressure algometry and tonic heat stimulation at an increasing temperature (45-48℃) during both trials. Compared with baseline, pain pressure threshold...... was reduced 2 and 6 h after LPS, while heat pain perception was accentuated at all testing temperatures after 2 but not 6 h. The magnitude of changes in pain perception did not correlate to cytokine release. No effect of transdermal nicotine or training status was observed. In conclusion, LPS administration...

  18. Motivations and Benefits of Student Volunteering: Comparing Regular, Occasional, and Non-Volunteers in Five Countries

    Directory of Open Access Journals (Sweden)

    Karen Smith

    2010-01-01

    Full Text Available Programmes targeting student volunteering and service learning are part of encouraging civic behaviour amongst young people. This article reports on a large scale international survey comparing volunteering amongst tertiary students at universities in Australia, Canada, New Zealand, the United Kingdom, and the United States of America. The data revealed high rates of student volunteering and the popularity of occasional or episodic volunteering. There were strong commonalities in student volunteering behaviour, motivations and benefits across the five Western predominately English-speaking countries. Altruism and self-orientated career motivations and benefits were most important to students; however volunteering and non-volunteering students differed in the relative value they attached to volunteering for CV-enhancement and social factors.

  19. Ohio 4-H Agents' and Volunteer Leaders' Perceptions of the Volunteer Leadership Development Program.

    Science.gov (United States)

    Kwarteng, Joseph A.; And Others

    1988-01-01

    This study found that six areas of volunteer leadership development are important to volunteers and 4-H agents. The areas are (1) recruiting, (2) training, (3) motivation, (4) recognition, (5) retention, and (6) supervision. (JOW)

  20. Do monetary rewards undermine intrinsic motivations of volunteers? Some empirical evidence for Italian volunteers

    OpenAIRE

    Fiorillo, Damiano

    2007-01-01

    Empirical studies show that intrinsic motivations increase the volunteer labour supply. This paper studies how monetary rewards to volunteers affect their intrinsic motivations. Using a sample of Italian volunteers, allowing to distinguish the type of volunteer, the paper shows that monetary rewards (extrinsic motivations) influence positively the choice to donate voluntary hours, while a low intrinsic motivation seems to decrease hours per week. Moreover, monetary rewards increase the hours ...

  1. Employer-supported volunteering benefits: gift exchange among employers, employees, and volunteer organizations

    OpenAIRE

    Booth, Jonathan E.; Park, Kyoung Won; Theresa M. Glomb

    2009-01-01

    Using gift exchange theory to explain the growing trend of employers offering employer-supported volunteering (ESV) benefits, this article discusses the creation of exchange relationships between the employer and employee and between the volunteer organization and employee. Hypotheses derived from the employee's perspective are tested with a nationally representative sample of volunteers (n=3,658). Findings suggest that ESV benefits are positively related to hours volunteered by the employee....

  2. More volunteers in football clubs. An evaluation of a method to increase the number of volunteers

    OpenAIRE

    Splinter, Mariëlle; Egli, Benjamin; Schlesinger, Torsten; Nagel, Siegfried

    2014-01-01

    An increasing number of clubs experience difficulties in recruiting and retaining sufficient numbers of volunteers to manage and staff their clubs (Lamprecht, Fischer, & Stamm, 2012). In order to facilitate volunteer recruitment, sport clubs need a specific strategy to recruit and retain volunteers for both formal positions and ad hoc tasks. Therefore, the intervention “More Volunteers in Football Clubs” was designed and its impact was evaluated in detail. The question this evaluation researc...

  3. Does It Pay to Volunteer? The Relationship Between Volunteer Work and Paid Work

    OpenAIRE

    Helene Jorgensen

    2013-01-01

    It is widely believed that volunteering will improve workers’ job prospects. The logic is that volunteering offers opportunities to expand work-related experience, develop new skills, and build a network of professional contacts. For young people with little history of paid employment it can also signal that a person would be a reliable and motivated employee. In spite of these widespread views about volunteering, surprisingly little research has been done on the effect of volunteering on emp...

  4. Volunteering with Newcomers: The Perspectives of Canadian- and Foreign-born Volunteers

    OpenAIRE

    Behnam Behnia

    2012-01-01

    Canadian- and foreign-born volunteers have contributed to the settlement of newcomers into Canadian society. Despite their important contribution, little has been reported about the experiences and perspectives of these volunteers. Using the information collected from face-to-face interviews with 60 Canadian- and foreign-born volunteers who support newcomers, this article discusses factors that motivate people to volunteer with newcomers. The study results revealed among other findings that (...

  5. Cardiovascular effects of cromakalim (BRL 34915) in healthy volunteers.

    OpenAIRE

    Fox, J S; Whitehead, E M; Shanks, R.G.

    1991-01-01

    1. The effect of oral doses of cromakalim 0.5, 1.0, 1.5 and 2.0 mg on several cardiovascular parameters was studied in healthy male volunteers. 2. In the first study, no dose of cromakalim reduced systolic or diastolic blood pressure in the supine or standing position. Reductions of diastolic blood pressure after exercise (P less than 0.01) were observed 4 h after administration of 2.0 mg. 3. There was a trend towards increased heart rate after 2.0 mg at all time intervals, and significant ch...

  6. The comparison of self esteem between volunteer and non volunteer students in universities sport in Iran

    Directory of Open Access Journals (Sweden)

    Reza Andam.

    2012-03-01

    Full Text Available Studies three concepts of transformational, transactional and laissez-faire leaderships as three independent and individual dimensions. This field study is descriptive and correlative. Statistical population of this study is the volunteer students in universities' sport associations of 10 regions of the country. Among 73 universities, 17 had active sport associations. Based on Morgan table, 231 students were selected as statistical sample (n=231 from which the results of 208 questionnaires were analyzed. Bass and Avolio (1995 Multifactor Leadership Questionnaire (MLQ was used to measure managers' leadership style of the universities' sport administrations. This questionnaire includes 41 questions with 5-value Lickert scale (1=never to 5=always. Choosing satisfaction from experiencing as the most important dimension of satisfaction shows volunteers' high level of satisfaction from experiences they have acquired in universities sport associations. The reason of this fact is that sport activity in the association is long term in nature. Sport association provides the students an opportunity to experience and use their experiences in their sport and work life. This study illustrates that girls are more satisfied than boys in all satisfaction dimensions (especially acquiring experience, career, commitment, and material in sport associations. Researches show that female students' satisfaction is more than male students' satisfaction and women's job satisfaction is more than men's job satisfaction. Thus, the higher degree of job satisfaction and experiencing in female students seems more justifying. Also, it's been cleared that sport students were more satisfied than other students in all satisfaction dimensions (especially acquiring experience, career, purposeful, and commitment

  7. Training Shelter Volunteers to Teach Dog Compliance

    Science.gov (United States)

    Howard, Veronica J.; DiGennaro Reed, Florence D.

    2014-01-01

    This study examined the degree to which training procedures influenced the integrity of behaviorally based dog training implemented by volunteers of an animal shelter. Volunteers were taught to implement discrete-trial obedience training to teach 2 skills (sit and wait) to dogs. Procedural integrity during the baseline and written instructions…

  8. Evaluating Presentation Skills of Volunteer Trainers.

    Science.gov (United States)

    Mohan, Donna K.

    A systematic method for evaluating the presentation skills of volunteer trainers would enable the discovery of hidden problems. It would also increase individual trainer skills and satisfaction and improve the overall effectiveness of the training program. A first step is to determine the general presentation skills a successful volunteer trainer…

  9. 75 FR 20891 - National Volunteer Week, 2010

    Science.gov (United States)

    2010-04-21

    ... United States of America the two hundred and thirty-fourth. (Presidential Sig.) [FR Doc. 2010-9415 Filed... natural disaster, volunteers are touching lives every day. Social entrepreneurs are pioneering innovative... national challenges. We are also investing in social innovation and volunteer management to give...

  10. Corporate volunteering - motivation for voluntary work

    Directory of Open Access Journals (Sweden)

    Debora Azevedo

    2008-07-01

    Full Text Available Nowadays, when the welfare state is a responsibility of the entire society, organizations in the private sector assume co-responsibility for social issues. They are also pressured by the challenges presented by technological advances and the globalization , involving new parameters and requirements for quality. In this context, the concept of Corporate Social Responsibility (RSC emerges as an option for solutions to the issues related to the company and the whole community. Among the actions of the RSC is the Corporate Volunteering-program, which aims to promote / encourage employes to do voluntary work. A central issue when talking about volunteering is the withdrawal of these (SILVA and FEITOSA, 2002; TEODÓSIO, 1999 and, in accordance with the Community Solidarity (1997, one of the possible causes for the withdrawal is the lack of clarity as to the motives and expectations that lead the person to volunteer themselves. This study uses qualitative research and triangulation of feedback from volunteers, coordinators of volunteers and social organizations, to present a framework from which it is possible to analyze the various motivations for the volunteer work. Key words: Corporate Volunteering program. Volunteering. Corporate social responsibility.

  11. A VNA-Organized Hospice Volunteer Program.

    Science.gov (United States)

    Dorang, Edith S.

    1981-01-01

    Factors contributing to the success of a hospice volunteer program, organized by a visiting nurse association, include patient involvement in defining agency expectations of a volunteer, careful selection of candidates, a well-planned training program, contractual agreements, and record-keeping. (CT)

  12. Personality Traits and Motives for Volunteering

    Directory of Open Access Journals (Sweden)

    Marija Juzbasic

    2015-07-01

    Full Text Available The aim of this study was to test the possibility of predicting volunteer motives based on five-factor model of personality in a sample of 159 volunteers from Zagreb, Osijek and Split. Data was collected using IPIP-300 personality questionnaire and Volunteer Functions Inventory. Results indicate that Croatian volunteers are agreeable, conscientious, altruistic, dutiful, and moral persons with artistic interests. Their most salient motives for volunteering are understanding and values. Hierarchical regression analysis confirmed that the five-factor model personality traits independently predict 17% of protective motive variance, 12% of values motive, 18% of career motive, 10% of understanding motive, and 12% of enhancement motive. Social motive was not explained by personality traits.

  13. Measuring the volume of caudate nucleus in healthy Chinese adults of the Han nationality on the high-resolution MRI

    International Nuclear Information System (INIS)

    Objective: To explore the normal range of the caudate nucleus' volume in Chinese adults of the Han nationality and provide morphological data for the construction of database for Chinese Standard Brain. Methods: This was a clinical multi-center study. One thousand Chinese healthy volunteers (age range =18 to 70) recruited from 16 hospitals were divided into 5 groups, i.e, Group A (age range = 18 to 30), B (age range =31 to 40), C (age range =41 to 50), D (age range =51 to 60), and E (age range =61 to 70). Each group contained 100 males and 100 females. All of the volunteers were scanned by MR using T1 weighted three-dimensional magnetization prepared rapid acquisition gradient echo sequence. The volume of caudate was measured manually using 3D volume analysis software. The difference of volumes of the caudate between male and female were analyzed by independent sample t-test, and among age groups by ANOVA. Pearson's correlation coefficient was used to characterize the relationship between volumes and age. The differences of measurements between left and right caudate nucleus were analyzed by paired t test. Results: (1) The mean volume of bilateral caudate nucleus in healthy Chinese adults was (10.973± 1.647) cm3. The mean volume of the the male's left and right caudate nucleus were (5.656±0.860) and (5.671±0.855) cm3 respectively,no significant differences were found between the volume of left and right caudate nucleus (t=1.230, P>0.05). The mean volume of the the female's left and right caudate nucleus were (5.287±0.774) and (5.331±0.766) cm3 respectively, and the right's was larger than the left's with significant differences (t=3.999, P<0.01); (2) Pearson correlation analysis showed a significant negative correlation between the nucleus volume and age (male and female's, left and right) (r=-0.561, -0.568, -0.548, -0.552, P<0.05). Conclusion: With high-resolution MRI and 3D volumetric analytic software (Midob), the volume of the caudate nucleus can be

  14. Pharmacokinetics of diltiazem hydrochloride delay-onset sustained-release pellet capsules in healthy volunteers

    OpenAIRE

    Xi-Qing Yan; Zhi-Gang Chen; Rong-Liang Wang; Jun Yang; Fang Ai; Yan-Juan Pan; Pei-Yong Qiu; Da-Xin Wang

    2013-01-01

    The pharmacokinetics (PK) of ordinary tablets and sustained release capsules of diltiazem hydrochloride in human clinical trials had been studied. The PK of diltiazem hydrochloride delay-onset sustained-release pellet capsules, a new dosage form, has not been reported, although it is very important to clinical use. In this paper, we investigated the PK of diltiazem hydrochloride delay-onset sustained-release pellet capsules and the food influence in Chinese healthy volunteers. The PK paramete...

  15. Volunteers for Researchers’ Night wanted

    CERN Multimedia

    Katarina Anthony

    2015-01-01

    Every year, on the last Friday of September, the European Researchers’ Night (see here) takes place in about 300 cities all over Europe - promoting research in engaging and fun ways for the general public. This year, CERN will be participating once again, hosting dozens of events across the Balexert shopping centre – and we’ll need YOUR help to make the celebration a success.   From film screenings and celebrity Q&A sessions to “Ask a Researcher” and build-your-own LEGO LHC events, this year’s Researchers’ Night is going to be jam-packed! The fun will kick off prior to the night itself with a mock-up of the LHC tunnel installed in the central court of the Balexert shopping centre, 8-12 September*. CERN people will be on hand to speak to shoppers about the LHC, and to encourage them to participate in Researchers’ Night! The CERN organisers are recruiting volunteers and support staff for Researchers’ ...

  16. Motivations for Deceased Organ Donation Among Volunteers in China: A Qualitative Research Study.

    Science.gov (United States)

    Yin, Zhike; Liu, Shan; Yan, Jin; Liu, Jia

    2016-01-01

    BACKGROUND To align with guiding principles on human organ and tissue transplantation published by the World Health Organization (WHO), the Red Cross Society of China (RCSC) launched a new nationwide organ donation program in 2010 to recruit organ donation volunteers. Despite severe shortage of donated organs, there is a very low rate of volunteering for organ donation among the Chinese population (only 0.03 donors per million population) in the national program. Motivating organ donation is the key to the success of organ transplantation in China. MATERIAL AND METHODS Semi-structured 45- to 60-min interviews were conducted among 34 volunteers. Data analysis was performed with Nvivo 8.0 software. RESULTS Six motivations for organ donation were identified: helping others/altruism, fulfilling long-cherished wishes, reducing the burdens, making the best use of everything, giving back to society, and life extension. Factors affecting the motivation of organ donation among volunteers in China included traditional values, personal experiences, role model effect, family support, and problems in the donation system. Possible strategies to improve organ donation included fostering a scientific concept of the body and death, focusing donation promotion efforts on certain groups, and simplifying the process of organ donation. CONCLUSIONS There are multiple reasons for Chinese people to register for organ donation, with helping others as the central motivation. PMID:27279558

  17. Condoms - male

    Science.gov (United States)

    Prophylactics; Rubbers; Male condoms; Contraceptive-condom; Contraception-condom; Barrier method-condom ... The male condom is a thin cover that fits over a man's erect penis . Condoms are made of: Animal ...

  18. Acute cortisol administration modulates EEG alpha asymmetry in volunteers : relevance to depression

    NARCIS (Netherlands)

    Tops, M; Wijers, AA; van Staveren, ASJ; Bruin, KJ; Den Boer, JA; Meijman, TF; Korf, J

    2005-01-01

    The acute effects of cortisol (35 mg) administration in 11 healthy male volunteers on resting frontal EEG asymmetry measured in the alpha band were investigated, using a within-subjects double-blind design. Results were indicative of a relative increase of right frontal activity with cortisol. This

  19. Source localization of sensory gating: a combined EEG and fMRI study in healthy volunteers

    DEFF Research Database (Denmark)

    Bak, Nikolaj; Glenthøj, Birte Yding; Rostrup, Egill;

    2011-01-01

    Reduced sensory gating appears to be among the core features in schizophrenia. The sources of sensory gating however are largely unknown. The aim of the current study was to identify these sources, with concurrent EEG and fMRI methodology. Twenty healthy male volunteers were tested with identical P...

  20. Measuring the volume of cingulate cortex in Chinese normal adults of the Han nationality on the high-resolution MRI

    International Nuclear Information System (INIS)

    Objective: To explore the normal range of cingulate cortex volumes of Chinese adults of the Han nationality and its relationship with age, which provide morphological data for the construction of database for Chinese Standard Brain. Methods: This is a clinical multi-center study. One thousand Chinese healthy volunteers (age range = 18 to 70) recruited from 15 hospitals were divided into 5 groups, i.e., Group A (age range = 18 to 30), B (age range =31 to 40), C (age range =41 to 50), D (age range =51 to 60), and E (age range =61 to 70). Each group contained 100 males and 100 females. All of the volunteers were scanned by MR using T1 weighted three-dimensional magnetization prepared rapid acquisition gradient echo sequence. Cingulate cortex volume (including bulk volume and the left/right volume) was measured semi-manually using 3D volume analysis software. Cingulate cortex volumes among age groups were compared by one-way ANOVA. Right and left cingulate cortex volumes between sexualities were analyzed by paired samples t test. The relationship between cingulate cortex volume and age was analyzed by Pearson correlations and regression analysis. Results: Cingulate cortex volumes of male and female were (20 347 ± 2504) and (19 432 ± 2184) mm3 respectively, and the male's was significantly larger than that of female's (two sample t'-test for independent samples, t'=6.156, P3 respectively, and those of female's were (10 064 ± 1407) and (9368 ± 1441) mm3 respectively. The volumes of cingulate cortex were significantly different between right and left in male or female (t=-12.960, -8.511, P3; right: (11212±1442), (11 096±1602), (11 040±1403), (10633±1638), (9604±1522) mm3] had statistical differences (F=16.738, 18.707, P3; right: (10 558± 1325), (10 266 ±1463), (10 100 ± 1497), (9779 ± 1304), (9617 ± 1254) mm3] also had significant differences (F=16.859,7.528,P<0.01). Bilateral cingulate cortex volume in both male and female were negatively correlated with

  1. Measuring the volume of the fourth ventricle in healthy Chinese adults of the Han nationality on the high-resolution MRI

    International Nuclear Information System (INIS)

    Objective: To explore the normal range of the fourth ventricle volume of Chinese adults of the Han nationality and provide morphological data for the construction of database for Chinese Standard Brain. Methods: This is a clinical multi-center study. One thousand Chinese healthy volunteers (age range = 18 to 70) recruited from 15 hospitals were divided into 5 groups, i.e., Group A (age range = 18 to 30), B (age range =31 to 40), C (age range =41 to 50), D (age range =51 to 60), and E (age range =61 to 70). Each group contained 100 males and 100 females. All of the volunteers were scanned by MR using T1 weighted three-dimensional magnetization prepared rapid acquisition gradient echo sequence. After three dimension data reconstruction, the volumes of the fourth ventricle were measured at sagittal view by automatic trace of Midobl. 2 combined with manual outlining. The difference of volumes of the fourth ventricle between male and female were analyzed by independent sample t test, and among age groups by ANOVA. Pearson's correlation coefficient was used to characterize the relationship between volumes of the fourth ventricle and age. Results: The fourth ventricle volumes of Group A-E were (2.1 ± 0.9), (2.1 ± 0.8), (2.2 ± 0.8), (2.1 ± 1.0) and (2.4 ± 0.8) ml respectively for male; those for female were (2.0 ± 0.7), (1.9 ± 0.6), (18 ± 0.6), (1.9 ± 0.7) and (2.0 ± 0.6) ml respectively. The fourth ventricle volumes of males were significantly larger than those of females (t=5.573, P=0.000); there were no significant differences among the female groups (F=1.788, P=0.130); there were significant differences among the male groups (F=2.639, P=0.033) and multiple comparison found that the 60 years old was the watershed with significant difference (P<0.05). Correlation between the change of males' volumes and the ages was not strong (r=0.119, P=0.008), and the females' volumes did not correlated with their ages (r=0.041,P=0.360). Conclusion: There are gender

  2. A Zen Approach to Volunteer Management.

    Science.gov (United States)

    Barnett, Michael L.; Cahill, Gloria

    2002-01-01

    New York University's Zen approach to community service focuses on the principles of mindfulness, awareness, compassion, and engagement in the present moment. It enables a more holistic approach to the measurement of volunteer management objectives. (SK)

  3. Monitoring and Evaluation of Volunteer Tourism

    DEFF Research Database (Denmark)

    Taplin, Jessica; Dredge, Dianne; Scherrer, Pascal

    2014-01-01

    in the project planning and implementation cycles of volunteer tourism organisations and destination managements. However, they can be both value-laden and politically charged, making an understanding of context, purpose and various approaches to monitoring and evaluation important. Drawing from evaluation...... highlights the important influence of context (the issue the volunteer tourism programme is addressing, the nature of the intervention, the setting, the evaluation context and the decision-making context), and identifies four dimensions of volunteer tourism (stakeholders, organisations, markets......The rapid expansion and commercialisation of the volunteer tourism sector and the potential for negative impacts on host communities have put the sector under increasing scrutiny. Monitoring and evaluation are key aspects of sustainable tourism planning and management, and play important roles...

  4. Motivation and Ethics within Volunteer Work

    OpenAIRE

    Holm, Marie-Louise Keck; Lopez, Kristina Halberg; Arildsen, Marie Otte; Kauppi, Suvi; Jacobsen, Nana Toft; Houmann, Amalie

    2015-01-01

    This project aims to investigate in the profiles of volunteers and their motivations. It further intends to create an ethical discussion about said motivations to generate a broader understanding of motivational factors and the ethical perspectives of them. In order to find the profiles and motivation, an interview and questionnaire were conducted of respectively an employee of MellemFolkeligt Samvirke and volunteers about to go abroad with the organisation. With the use of Abraham H. Maslow,...

  5. International Task Force on Volunteer Cleft Missions.

    Science.gov (United States)

    Yeow, Vincent K L; Lee, Seng-Teik T; Lambrecht, Thomas J; Barnett, John; Gorney, Mark; Hardjowasito, Widanto; Lemperle, Gottfried; McComb, Harold; Natsume, Nagato; Stranc, Mirek; Wilson, Libby

    2002-01-01

    The International Task Force on Volunteer Cleft Missions was set up to provide a report to be presented at the Eighth International Congress of Cleft Palate and Associated Craniofacial Anomalies on September 12, 1997, in Singapore. The aim of the report was to provide data from a wide range of different international teams performing volunteer cleft missions and, thereafter, based on the collected data, to identify common goals and aims of such missions. Thirteen different groups actively participating in volunteer cleft missions worldwide were selected from the International Confederation of Plastic and Reconstructive Surgery's list of teams actively participating in volunteer cleft missions. Because of the time frame within which the committee had to work, three groups that did not respond by the stipulated deadline were omitted from the committee. The represented members and their respective institutions have undertaken more than 50 volunteer cleft missions to underdeveloped nations worldwide within the last 3 years. They have visited over 20 different countries, treating more than 3,500 patients worldwide. Based on the data collected and by consensus, the committee outlined recommendations for future volunteer cleft missions based on 1) mission objectives, 2) organization, 3) personal health and liability, 4) funding, 5) trainees in volunteer cleft missions, and 6) public relations. The task force believed that all volunteer cleft missions should have well-defined objectives, preferably with long-term plans. The task force also decided that it was impossible to achieve a successful mission without good organization and close coordination. All efforts should be made, and care taken, to ensure that there is minimal morbidity and no mortality. Finally, as ambassadors of goodwill and humanitarian aid, the participants must make every effort to understand and respect local customs and protocol. The main aims are to provide top-quality surgical service, train local

  6. Is volunteering for everyone? Volunteering opportunities for young ex-offenders

    OpenAIRE

    Kirby, Amy

    2016-01-01

    PURPOSE: The purpose of the study was to explore volunteering opportunities for young adults with criminal records (‘young ex-offenders’). DESIGN/METHODOLOGY/APPROACH: The study was conducted primarily in one London borough. It involved mapping volunteering opportunities for young ex-offenders and conducting in-depth interviews with young ex-offenders and practitioners from volunteer-involving organisations and resettlement organisations. FINDINGS: Several perceived benefits of...

  7. Individual and Social Predictors of Prosocial Behaviour among Chinese Adolescents in Hong Kong

    Directory of Open Access Journals (Sweden)

    Frank H.Y. Lai

    2015-05-01

    Full Text Available Based on the human ecological model, this study hypothesized that individual competence in empathy, prosocial moral reasoning, and social influence from parents, peers, and school are the key determinants of prosocial behaviour among Chinese adolescents in Hong Kong. We recruited a sample of high school students who engaged in volunteering activities regularly (N = 580. They completed a self-administrated questionnaire designed to measure prosocial behaviour and its hypothesized predictors using a number of standardized instruments. The results of multiple regression show that social influence factors, including peer, school, and parent influence, are strong predictors of helping intention and prosocial behaviour, while individual competence factors like empathy and prosocial moral reasoning are not. Male participants had higher empathy scores and helping intention than males, perceived their parents as more helpful, and their schools as more supportive of prosocial behaviour. However, the significant predictors of prosocial behaviour and helping intention were similar across gender. The findings indicate that social influence is strongly linked to prosocial behaviour. This implies that socialization and social support for prosocial norms and behaviour can exert a powerful influence on the behaviour of young people in a Chinese population.

  8. Gender Differences in Risk Aversion Among Chinese University Students.

    Science.gov (United States)

    Lam, Desmond

    2015-12-01

    This paper examines gender differences in risk aversion among Chinese university students. Chinese females are proposed to be more risk averse and require a higher risk premium when faced with a gamble option in the gain-domain frame as compared to Chinese males. Two groups of 100 participants each (male = 100 and female = 100 in total) were recruited to fill up questionnaires that included items relating to objective probability lotteries. Within each group, it was found that Chinese males and females did not differ in their risk aversion. However, results show that Chinese males tend to react more readily to rising risk premium by taking up options with higher expected values when compared to Chinese females. Current findings will have useful implications to marketers (particularly, promoters of gambling products) and problem gambling counselors. PMID:25112219

  9. 28 CFR 551.60 - Volunteer community service projects.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Volunteer community service projects. 551... MANAGEMENT MISCELLANEOUS Volunteer Community Service Projects § 551.60 Volunteer community service projects. (a) A volunteer community service project is a project sponsored and developed by local government...

  10. The White Lion Volunteer Program in South Africa: A Study of Volunteer Needs

    Directory of Open Access Journals (Sweden)

    Boretti Tanya

    2014-01-01

    Full Text Available Volunteer tourists are motivated to participate in volunteer programs due to their need to ‘do something different’, ‘see another culture’ and ‘to escape’, amongst others. The research aims to determine the internal and external factors that motivate individuals to participate in the Tsau! Global White Lion Protection Trust’s (GWLPT volunteer program. Maslow’s theory of human motivation and Frankl’s study of human behaviour are used to explore intrinsic factors whereas extrinsic or macro environmental factors of influence are also investigated. A mixed method approach with focus group discussions and an online survey is followed. A background to the volunteer program is presented with the activities available to volunteers. The key findings indicate that most volunteers are young females that volunteer for a minimum of two weeks; are internally motivated to ‘give back and be useful’ and ‘to work with the white lions’ for the purpose of self-actualisation. External motivation is mainly social in terms of concern about the well-being of the lions, and South Africa being an economically affordable destination. The GWLPT strives to fulfil the needs of volunteers, especially intrinsic needs associated with self-actualisation and self-transcendence.

  11. Impact of cadmium exposure on male sex hormones: a population-based study in China.

    Science.gov (United States)

    Zeng, Xiangbin; Jin, Taiyi; Buchet, Jean P; Jiang, Xuezi; Kong, Qinghu; Ye, Tingting; Bernard, Alfred; Nordberg, Gunnar F

    2004-11-01

    The objective of this study was to investigate the possible effects of environmental cadmium (Cd) exposure on the levels of serum sex hormones in a Chinese population group. A total of 263 male volunteers were included. Blood samples were collected for the determination of serum testosterone (T), measured by radioimmunoassay, and follicle stimulating hormone (FSH) and luteinizing hormone (LH), both measured by enzyme immunoassays. Urinary and blood Cd were analyzed by atomic absorption spectroscopy (AAS). We found a dose-response relationship between urinary Cd excretion and the prevalence of abnormally high serum T levels, but, through multiple regression analysis, we could not trace exposure to Cd as a significant determinant of serum T levels. Exposure to Cd also failed to influence the levels of FSH and LH in serum. In contrast, we found that age, body mass index (BMI), and smoking habits are significant determinants of FSH and LH and of T and LH, respectively. We conclude that oral Cd exposure is not a critical determinant of hormone homeostasis in males, but lifestyle and some biological factors, such as age and BMI, are important. The relationship found between urinary Cd and high T levels may be of importance for male reproductive morbidity and should be investigated further. PMID:15364602

  12. Impact of cadmium exposure on male sex hormones: a population-based study in China

    International Nuclear Information System (INIS)

    The objective of this study was to investigate the possible effects of environmental cadmium (Cd) exposure on the levels of serum sex hormones in a Chinese population group. A total of 263 male volunteers were included. Blood samples were collected for the determination of serum testosterone (T), measured by radioimmunoassay, and follicle stimulating hormone (FSH) and luteinizing hormone (LH), both measured by enzyme immunoassays. Urinary and blood Cd were analyzed by atomic absorption spectroscopy (AAS). We found a dose-response relationship between urinary Cd excretion and the prevalence of abnormally high serum T levels, but, through multiple regression analysis, we could not trace exposure to Cd as a significant determinant of serum T levels. Exposure to Cd also failed to influence the levels of FSH and LH in serum. In contrast, we found that age, body mass index (BMI), and smoking habits are significant determinants of FSH and LH and of T and LH, respectively. We conclude that oral Cd exposure is not a critical determinant of hormone homeostasis in males, but lifestyle and some biological factors, such as age and BMI, are important. The relationship found between urinary Cd and high T levels may be of importance for male reproductive morbidity and should be investigated further

  13. Motives for Volunteering: Categorization of Volunteers' Motivations Using Open-ended Questions

    Directory of Open Access Journals (Sweden)

    Fernando Chacón

    2010-12-01

    Full Text Available Most studies of volunteers’ motivations use standardized questionnaires with one of the most commonly-used being the Volunteer Function Inventory. Open-ended questions about what drives individuals to be volunteers are seldom used. We hypothesize that questionnaires tend to overestimate the number of motivations and to underestimate their variety. Therefore, in this paper we analyze the answers of 1515 volunteers to an open-ended question and categorize these answers. Results show that volunteers give an average of 2 motivations, fewer than the questionnaires, and that the Value motivation is the most frequently mentioned and the most important for volunteers. In addition, this motivation coexists with other motivations, which are lacking in the standard questionnaires, such as Organizational Commitment, Personal Development, Religiosity, Social Change or Interest in the Activity.

  14. Sport volunteerism: a study on volunteering motivations in university students

    OpenAIRE

    Mirsafian, Hamidreza; Mohamadinejad, Azadeh

    2012-01-01

    Volunteers form an integral part of the sport industry. Recognition of the volunteers' motivations to attract them in sport programs is the aim of each organization. Although several studies have been conducted regarding volunteers in sport, there is not a clear idea about the effective motivational factors on the sport volunteers on different communities. This subject might be due to the effects of social variables on the volunteering motivations. The aim of this study was to analyze the mot...

  15. THE STUDY OF SELF-CONCEPT BETWEEN VOLUNTEER AND NON-VOLUNTEER STUDENTS IN SPORT OF UNIVERSITIES

    Directory of Open Access Journals (Sweden)

    Reza Andam

    2013-03-01

    Full Text Available Understanding personality characteristics of volunteers are important for their recruitment and retention in sport associations. This study compared self-concept as a personality characteristic between volunteer and non-volunteer students in sport associations. The method of this research was survey and descriptive. The statistical population consisted of volunteer and non-volunteer students in sport associations of Iran universities. Two hundred and fifty two students (120 volunteers and 132 non-volunteers from 10 universities were selected as subjects by using random clustered sampling method. Pyryt and Mandaglio Self Perceived Survey (PMSPS was used to collect the data. The content and face reliability of questionnaire was checked and confirmed. Cronbach’s alpha coefficient was used to test the reliability of the questionnaire (alfa=0.90. Independent t test and U Mann-Whitney test were used for comparison of the factors between volunteers and non-volunteers. Findings of this study indicated that there was a significant difference between volunteer and non-volunteer students in social and athletic self-concept. The mean of scientific and value factors were higher in volunteers than non-volunteers, however, they were not statistically significant. We concluded that the nature of sport (active and sport volunteering (social encourage students who have higher self-concept for volunteering. Moreover, the characteristics of sport associations can increase self-concept in sport volunteers.

  16. Motivations for Youth Volunteer Participation: Types and Structure--An Analysis of Interviews with Twenty-Four Young Volunteers

    Science.gov (United States)

    Luping, Wu

    2011-01-01

    Scholars who study volunteer activities are attaching ever greater importance to the motivations of volunteers who participate in volunteer activities. However, deficiencies are, on the whole, to be found in the empirical studies by scholars in China on the participating volunteers' motivations. To make up for the deficiencies in the research on…

  17. The volunteer programme ‘Night Ravens’:

    DEFF Research Database (Denmark)

    Larsen, Britt Østergaard; Bendix Kleif, Helle; Kolodziejczyk, Christophe

    2015-01-01

    with NR organizations to districts without NR organizations. The results show no difference in the crime rates between Danish postcode districts with and without the NR programme. Hence, we cannot identify positive effects of situational crime prevention when evaluating this Scandinavian volunteer......The volunteer programme ‘Night Ravens’ (NR) was founded in Sweden in 1987 and has, over the years, developed into a Scandinavian concept covering large areas of Sweden, Denmark, Norway, Greenland and the Faroe Islands. The NR programme is a crime prevention initiative with adults walking the...... streets at night in identifiable ‘uniforms’ in areas with high activity. The purpose of this study is to evaluate the effects of the NR programme in Denmark based on a volunteer set-up with a less intrusive approach to situational crime prevention than, for instance, hot spot policing. The analyses are...

  18. Chinese Cooking.

    Science.gov (United States)

    Kane, Tony

    This unit, intended for secondary level students, is a general introduction to Chinese cooking. It is meant to inform students about the origins of Chinese cooking styles in their various regional manifestations, and it can be used to discuss how and why different cultures develop different styles of cooking. The first part of the unit, adapted…

  19. Volunteered Cloud Computing for Disaster Management

    Science.gov (United States)

    Evans, J. D.; Hao, W.; Chettri, S. R.

    2014-12-01

    Disaster management relies increasingly on interpreting earth observations and running numerical models; which require significant computing capacity - usually on short notice and at irregular intervals. Peak computing demand during event detection, hazard assessment, or incident response may exceed agency budgets; however some of it can be met through volunteered computing, which distributes subtasks to participating computers via the Internet. This approach has enabled large projects in mathematics, basic science, and climate research to harness the slack computing capacity of thousands of desktop computers. This capacity is likely to diminish as desktops give way to battery-powered mobile devices (laptops, smartphones, tablets) in the consumer market; but as cloud computing becomes commonplace, it may offer significant slack capacity -- if its users are given an easy, trustworthy mechanism for participating. Such a "volunteered cloud computing" mechanism would also offer several advantages over traditional volunteered computing: tasks distributed within a cloud have fewer bandwidth limitations; granular billing mechanisms allow small slices of "interstitial" computing at no marginal cost; and virtual storage volumes allow in-depth, reversible machine reconfiguration. Volunteered cloud computing is especially suitable for "embarrassingly parallel" tasks, including ones requiring large data volumes: examples in disaster management include near-real-time image interpretation, pattern / trend detection, or large model ensembles. In the context of a major disaster, we estimate that cloud users (if suitably informed) might volunteer hundreds to thousands of CPU cores across a large provider such as Amazon Web Services. To explore this potential, we are building a volunteered cloud computing platform and targeting it to a disaster management context. Using a lightweight, fault-tolerant network protocol, this platform helps cloud users join parallel computing projects

  20. Condoms - male

    Science.gov (United States)

    ... contained in a male's semen reach a woman's vagina, pregnancy may occur. Condoms work by preventing sperm ... coming in contact with the inside of the vagina. If condoms are used correctly every time intercourse ...

  1. The Invention and Institutionalization of Volunteer Centers

    DEFF Research Database (Denmark)

    Lorentzen, Håkon; Henriksen, Lars Skov

    2014-01-01

    This article presents and explains differences in governmental implementation strategies of volunteer centers in Norway and Denmark. In the first part, we describe the emergence of centers, focusing on shifting policies and governmental initiatives. The second part aims at explaining the observed...... Norwegian centers lacked a national coordinating unit. Third, an independent legal form in which local associations are members may have helped Danish centers bring about a sense of local ownership. In Norway, volunteer centers had weak ties to other local voluntary associations and were at times perceived...

  2. Does it Pay for Women to Volunteer?

    OpenAIRE

    Sauer, Robert M.

    2015-01-01

    This paper estimates the economic and non-economic returns to volunteering for prime-aged women. A woman's decision to engage in unpaid work, and to marry and have children, is formulated as a forward-looking discrete choice dynamic programming problem. Simulated maximum likelihood estimates of the model indicate that an extra year of volunteer experience increases wage offers in part-time work by 8.3% and wage offers in full-time work by 2.4%. The behavioral model also reveals an adverse sel...

  3. Altered cortical causality after remifentanil administration in healthy volunteers

    DEFF Research Database (Denmark)

    Khodayari-Rostamabad, Ahmad; Graversen, Carina; Olesen, Soren S;

    2014-01-01

    Alterations in cortical causality information flow induced by remifentanil infusion in healthy volunteers was investigated in a placebo-controlled double-blind cross-over study. For each of the 21 enrolled male subjects, 2.5 minutes of resting electroencephalography (EEG) data were collected before...... features being reproducible between the two baseline recordings, several PSI features were altered by remifentanil administration in comparison to placebo. Furthermore, several of the PSI features altered by remifentanil were correlated to changes in both CRT and pain scores. The results indicate that...... remifentanil administration influence the information flow between several brain areas. Hence, the EEG causality approach offers the potential to assist in deciphering the cortical effects of remifentanil administration....

  4. 非洛地平缓释片在中国健康男性的生物等效性%Bioequivalence of felodipine extended release tablets in Chinese healthy male subjects

    Institute of Scientific and Technical Information of China (English)

    许俊羽; 赵侠; 孙严彤; 顾景凯; 王梓凝; 张冬梅; 周颖; 梁雁; 崔一民

    2013-01-01

    目的 评价2种非洛地平缓释片在健康中国男性人体的生物等效性.方法 用双交叉设计,24名健康男性受试者随机分为2组,单剂量口服非洛地平缓释片试验药物或对照药物5mg,用液相色谱-串联质谱法测定血浆非洛地平血药浓度,用DAS 2.0软件计算药代动力学参数.结果 试验药物与对照药物的Cmax分别为(2.15±1.37),(1.67±0.87) ng·mL-1;Tmax分别为(5.40±3.42),(5.85±4.84)h;t1/2分别为(16.51±5.82),(18.78±8.16)h;AUCo-72h分别为(37.68±22.05),(34.71±20.88)ng·h·mL-1;AUCo-∞分别为(39.90±23.64),(37.93±23.75)ng·h·mL-1;Cmax、AUCo-r2h和AUCo-∞的90%可信区间分别为109.6% ~ 141.6%,99.2% ~120.2%和96.2% ~117.8%.两制剂的Tmax非参数法检验差异无统计学意义.试验药物对于对照药物的平均相对生物利用度F为(114.0±33.7)%.结论 2种非洛地平缓释片剂在中国健康男性受试者体内具有生物等效性.%Objective To evaluate the bioequivalence of the two felo-dipine extended release tablets in Chinese healthy male subjects. Methods A single oral dose 5 mg of test and reference felodipine extended release tablets were given to 24 subjects according to an open randomized crossover design. The concentrations of felodipine in plasma were determined by LC - MS/MS. The pharmacokinetic parameters were calculated and the bioequivalence was compared by DAS 2. 0. Results The main pharmacokinetic parameters of felodipine of the test and reference preparations were as follows:Cmax were (2. 15 ± 1. 37) and (1. 67 ±0. 87) ng · mL-1; Tmax were (5. 40 ±3.42), (5. 85 ±4. 84) h; t1/2 were (16. 51 ±5.82) and (18.78 ±8. 16) h; AUC0-72hwere (37.68 ±22.05) and (34.71 ±20.88) ng · H · mL-1; AUC0_. Were (39. 90 ± 23. 64) and (37. 93 ±23. 75) ng · H · mL-1. The 90% confidential interval of Cmax, AUC0-72h and AUC0_∞ of tested formulation were 109. 6% ~ 141. 6% , 99. 2% ~ 120. 2 % and 96. 2% ~ 117. 8% . There was no

  5. 中国男性青年军人对同性恋者及其服兵役的态度%Attitudes of Chinese young male military personnel toward homosexuality in the army

    Institute of Scientific and Technical Information of China (English)

    阎同军; 王焕林; 王彦彦; 毕银花

    2009-01-01

    目的 评价中国男性青年军人对同性恋者及同性恋者服兵役的态度.方法 随机整群抽取1368名南京军区陆军某部现役男性青年军人,采用军人对男/女同性恋者的态度量表(ATLG)(中文版)及军人对军队中的同性恋者的态度量表(ATHM)(中文版)进行测最,并对其结果进行统计分析.结果 ATLG量表最低分22,最高分80,平均(45.59±7.90)分;ATHM量表最低分14,最高分为53,平均(29.43±6.56)分;中国男性青年军人对男、女同性恋者均持否定的态度,尤其对男同性恋者更加反感(t=7.212,P=0.000);未发现ATLG量表、ATHM量表评分与年龄、军龄、职别、是否独生子女及受教育程度存在相关;ATLG评分与ATHM评分间存在正相关(r=0.491,P<0.01).结论 中国当代军人对同性恋者服役的态度既表示轻度支持,存在较高的宽容度,同时又感到与同性恋者在一起"不舒服",且这种反感多表现在道德及社会舆论范畴.%Objective To assess attitudes of Chinese young male military personnel with regard to homosexuality and homosexuality served in the army. Methods 1368 enlisted military personnel from Nanjing Military Region chosen hy random cluster sampling were tested and analyzed by Military Personnel' s Attitudes Toward Lesbian and Gay men Scale ( ATLG) and Military Personnel' s Attitudes Toward Homosexuals in the Military Scale (ATHM). Results The summed scores on the ATLG scale ranged from 22 to 80 (45. 59 ± 7. 90) , and the summed scores on the ATHM scale ranged from 14 to 53 (29.43 ± 6. 56). Attitudes of the present sample toward lesbians and gay men in general were found to be negative, especially toward gay men(t = 7.212, P = 0.000). There was no relation found between scale scores and the demographic variables such as age, length of military service, official rank, education , while the Pearson correlation coefficients between ATLG scores and ATHM scores was high(r=0.491, P<0.01). Conclusion Attitudes toward

  6. Citizen volunteer water monitoring on Lake Mitchell

    OpenAIRE

    Deutsch, W.

    2005-01-01

    Publication includes a timeline of AWW and the Lake Mitchell Home Owners and Boat Owners Association as well as: Lake Facts and Figures; Lake Oxygen and Temperature Cycles; Lake Clarity and Eutrophication; Water Quality Differences in the Watershed; Why Is Volunteer Monitoring Important?; and Alabama's Rich Water Resources and AWW.

  7. The Benefits of Volunteering for Psychology Students

    Science.gov (United States)

    Bromnick, Rachel; Horowitz, Ava; Shepherd, Daniel

    2012-01-01

    Within the current economic climate students are seen as needing more than a degree to succeed in securing graduate employment. One way that students chose to enhance their employability is through engaging in voluntary work. In this empirical study, undergraduate psychology students' reasons for volunteering are explored within the context of…

  8. Volunteers in Wikipedia: Why the Community Matters

    Science.gov (United States)

    Baytiyeh, Hoda; Pfaffman, Jay

    2010-01-01

    Wikipedia is a reliable encyclopedia with over seven million articles in several languages all contributed and maintained by volunteers. To learn more about what drives people to devote their time and expertise to building and maintaining this remarkable resource, surveys with Likert-scaled items measuring different types of motivations were…

  9. International Volunteering: Employability, Leadership and More

    Science.gov (United States)

    Rothwell, Andrew; Charleston, Brandon

    2013-01-01

    Purpose: The purpose of this paper is to investigate the experiences of individuals in transition between education and work during international volunteering expeditions. While it was expected that outcomes might include employability enhancement and skill development, the authors aimed to clarify what the main factors were, examine employability…

  10. BOINC service for volunteer cloud computing

    International Nuclear Information System (INIS)

    Since a couple of years, a team at CERN and partners from the Citizen Cyberscience Centre (CCC) have been working on a project that enables general physics simulation programs to run in a virtual machine on volunteer PCs around the world. The project uses the Berkeley Open Infrastructure for Network Computing (BOINC) framework. Based on CERNVM and the job management framework Co-Pilot, this project was made available for public beta-testing in August 2011 with Monte Carlo simulations of LHC physics under the name “LHC at home 2.0” and the BOINC project: “Test4Theory”. At the same time, CERN's efforts on Volunteer Computing for LHC machine studies have been intensified; this project has previously been known as LHC at home, and has been running the “Sixtrack” beam dynamics application for the LHC accelerator, using a classic BOINC framework without virtual machines. CERN-IT has set up a BOINC server cluster, and has provided and supported the BOINC infrastructure for both projects. CERN intends to evolve the setup into a generic BOINC application service that will allow scientists and engineers at CERN to profit from volunteer computing. This paper describes the experience with the two different approaches to volunteer computing as well as the status and outlook of a general BOINC service.

  11. The White Lion Volunteer Program in South Africa: A Study of Volunteer Needs

    OpenAIRE

    Boretti Tanya; Fairer-Wessels Felicité

    2014-01-01

    Volunteer tourists are motivated to participate in volunteer programs due to their need to ‘do something different’, ‘see another culture’ and ‘to escape’, amongst others. The research aims to determine the internal and external factors that motivate individuals to participate in the Tsau! Global White Lion Protection Trust’s (GWLPT) volunteer program. Maslow’s theory of human motivation and Frankl’s study of human behaviour are used to explore intrinsic factors whereas extrinsic or macro env...

  12. Clinical evaluation of purified Shilajit on testosterone levels in healthy volunteers.

    Science.gov (United States)

    Pandit, S; Biswas, S; Jana, U; De, R K; Mukhopadhyay, S C; Biswas, T K

    2016-06-01

    Purified Shilajit, an Ayurvedic rasayana, was evaluated in healthy volunteers of age between 45 and 55 years for its effect on male androgenic hormone viz. testosterone in a randomised, double-blind, placebo-controlled clinical study at a dose of 250 mg twice a day. Treatment with Shilajit for consecutive 90 days revealed that it has significantly (P DHEAS) compared with placebo. Gonadotropic hormones (LH and FSH) levels were well maintained. PMID:26395129

  13. Prosocial Behavior Motivation of Acheness Volunteers in Helping Tsunami Disaster Victims

    OpenAIRE

    Safrilsyah Safrilsyah; Kamaruzaman Jusoff; Rahmat Fadhil

    2009-01-01

    The purpose of this research is to explore pro-social behavior motivation of Acheness volunteers, who performed humanitarian activities in helping Tsunami victims in Nanggroe Aceh Darussalam, Indonesia. The research was carried out from July 2005 to February 2006. Data were collected from 147 university students in Banda Aceh and Aceh Besar (86 males and 91 females) using two types of questionnaires: (1) Movitavion of Prosocial Behavior Index (MPBI) and Type of Prosocial Behavior Questionnair...

  14. Chinese astronomy

    OpenAIRE

    Macfarlane, Alan; Cullen, Christopher

    2004-01-01

    Standing in the observatory in Beijing, Christopher Cullen discusses the nature and sophistication of Chinese astronomy in the medieval period. The political as well as the intellectual interest in astronomy is outlined.

  15. Chinese Confucianism

    OpenAIRE

    Macfarlane, Alan; Cullen, Christopher

    2004-01-01

    Confucianism has deeply influenced Chinese civilization. Christopher Cullen describes its effect on education, social structure and knowledge over the past centuries, against the backdrop of a Confucian building in Beijing.

  16. Occupant kinematics in low-speed frontal sled tests: Human volunteers, Hybrid III ATD, and PMHS.

    Science.gov (United States)

    Beeman, Stephanie M; Kemper, Andrew R; Madigan, Michael L; Franck, Christopher T; Loftus, Stephen C

    2012-07-01

    A total of 34 dynamic matched frontal sled tests were performed, 17 low (2.5g, Δv=4.8kph) and 17 medium (5.0g, Δv=9.7kph), with five male human volunteers of approximately 50th percentile height and weight, a Hybrid III 50th percentile male ATD, and three male PMHS. Each volunteer was exposed to two impulses at each severity, one relaxed and one braced prior to the impulse. A total of four tests were performed at each severity with the ATD and one trial was performed at each severity with each PMHS. A Vicon motion analysis system, 12 MX-T20 2 megapixel cameras, was used to quantify subject 3D kinematics (±1mm) (1kHz). Excursions of select anatomical regions were normalized to their respective initial positions and compared by test condition and between subject types. The forward excursions of the select anatomical regions generally increased with increasing severity. The forward excursions of relaxed human volunteers were significantly larger than those of the ATD for nearly every region at both severities. The forward excursions of the upper body regions of the braced volunteers were generally significantly smaller than those of the ATD at both severities. Forward excursions of the relaxed human volunteers and PMHSs were fairly similar except the head CG response at both severities and the right knee and C7 at the medium severity. The forward excursions of the upper body of the PMHS were generally significantly larger than those of the braced volunteers at both severities. Forward excursions of the PMHSs exceeded those of the ATD for all regions at both severities with significant differences within the upper body regions. Overall human volunteers, ATD, and PMHSs do not have identical biomechanical responses in low-speed frontal sled tests but all contribute valuable data that can be used to refine and validate computational models and ATDs used to assess injury risk in automotive collisions. PMID:22342960

  17. Shared rewarding overcomes defection traps in generalized volunteer's dilemmas

    CERN Document Server

    Chen, Xiaojie; Dieckmann, Ulf

    2013-01-01

    For societies to produce or safeguard public goods, costly voluntary contributions are often required. From the perspective of each individual, however, it is advantageous not to volunteer such contributions, in the hope that other individuals will carry the associated costs. This conflict can be modeled as a volunteer's dilemma. To encourage rational individuals to make voluntary contributions, a government or other social organizations can offer rewards, to be shared among the volunteers. Here we apply such shared rewarding to the generalized volunteer's dilemma, in which a threshold number of volunteers is required for producing the public good. By means of theoretical and numerical analyses, we show that without shared rewarding only two evolutionary outcomes are possible: full defection or coexistence of volunteers and non-volunteers. We show that already small rewards destabilize full defection, stabilizing small fractions of volunteers instead. Furthermore, at these intermediate reward levels, we find ...

  18. Normal blood magnesium levels in volunteers of Rawalpindi by atomic absorption absorption technique

    International Nuclear Information System (INIS)

    Magnesium levels in whole blood samples of 67 healthy volunteers (mean 6.46 -+ 0.221; range 1.345 - 13.163 mg/dL) of Rawalpindi district have been determined by flame atomic absorption spectrophotometric method. Magnesium levels of 41 male and 26 female subjects including doctors, nurses, patients attendees, medical students, sweepers and peons of Rawalpindi Medical College and Rawalpindi General Hospital revealed the normal mean blood levels of 6.088 - + 0.258 mg/dL (range 1.345 - 10.679 mg/dL)and 7.060 -+ 0.375 mg/dL (range 4.495 - 13.163 mg/dL),P<0.05 respectively. Only 10 male volunteers were smokers exhibiting 6.768 -+ 0.558 mg/dL (range 4.466 -10.679 mg/dL). Significant relationship was found in magnesium levels between males and females of poor socio-economic group (P<0.05). No relationship occurred between male smokers and non-smokers and magnesium levels in the age groups of males or females or both, when data was compared by 't' test. (author)

  19. Molecular helpers wanted... Call for volunteers!

    CERN Document Server

    2008-01-01

    The Task Force in charge of the organization of the LHC Inauguration is looking for 40 volunteers to support the team of molecular cooks directed by international chef Ettore Bocchia. The "molecular" volunteers will help in the preparation of liquid nitrogen ice-cream. Your help is requested from 12h to 18h on October 21st. Your participation in a general rehearsal on October 20th is also required - (the time of the rehearsal will be communicated at a later moment). Dress code: black pants and shoes, long sleeved white shirt. Do not miss this opportunity to take part in an extraordinary event! For further information and to enrol, contact: mailto:Catherine.Brandt@cern.ch

  20. AVOCLOUDY: a simulator of volunteer clouds

    DEFF Research Database (Denmark)

    Sebastio, Stefano; Amoretti, Michele; Lluch Lafuente, Alberto

    2015-01-01

    application, intelligent agents constitute a feasible technology to add autonomic features to cloud operations. Furthermore, the volunteer computing paradigm—one of the Information and Communications Technology (ICT) trends of the last decade—can be pulled alongside traditional cloud approaches, with the...... purpose to ‘green’ them. Indeed, the combination of data center and volunteer resources, managed by agents, allows one to obtain a more robust and scalable cloud computing platform. The increased challenges in designing such a complex system can benefit from a simulation-based approach, to test autonomic...... management solutions before their deployment in the production environment. However, currently available simulators of cloud platforms are not suitable to model and analyze such heterogeneous, large-scale, and highly dynamic systems. We propose the AVOCLOUDY simulator to fill this gap. This paper presents...

  1. AN ANDROID APPLICATION FOR VOLUNTEER BLOOD DONORS

    Directory of Open Access Journals (Sweden)

    Sultan Turhan

    2015-05-01

    Full Text Available There is an expectation that the blood will always be there when it is really needed. Blood donor volunteers constitute the main supply source in an effective blood supply chain management. They feed blood stocks through their donation. In an emergency situation, if the stocks are insufficient, the only source of blood supply will be the people who come to the health center and donate the blood on a voluntary basis. It is certain that time is a very important component in such situation. For this reason, the health care center should call the nearest available donor in order to ensure to get the service as quickly as possible. A smart phone application is developed to facilitate the identification of the nearest available blood donor volunteer and the communication with him/her in the emergency situations where the blood can’t be supplied through the blood banks’ stocks. In this paper this application will be presented.

  2. Volunteer Tourism Program Development, Case Vietnam Heritage Travel

    OpenAIRE

    Nguyen, Leminh

    2012-01-01

    The purpose of this thesis project is to figure out what kinds of volunteer tourism programs should be developed for Vietnam Heritage Travel, a tour operator in Vietnam, and what business and volunteering factors need to be considered for the development. In order to answer those research questions, the thesis reviewed current studies and researches on volunteer tourism, including its definitions, theoretical frameworks and practices, various types of projects worldwide and overview of volunt...

  3. Factors Associated with Knowledge of and Willingness for Adult Male Circumcision in Changsha, China

    OpenAIRE

    Zeng, Mingqiang; Wang, Ling; Chen, Caifang; Zeng, Fanchang; Huang, Liang; Xue, Ruizhi; Chen, Junjie; Gao, Benmin; Tang, Zhengyan

    2016-01-01

    Background Male circumcision (MC) has been shown to reduce the risk of male genital diseases. MC is not commonly practiced among Chinese males and little is known about the factors associated with their knowledge of and willingness for MC. This study was to explore the knowledge regarding the foreskin among Chinese males and to identify factors associated with their willingness to undergo circumcision. Methods A total of 237 patients with redundant prepuce/phimosis were interviewed through fa...

  4. AN ANDROID APPLICATION FOR VOLUNTEER BLOOD DONORS

    OpenAIRE

    Sultan Turhan

    2015-01-01

    There is an expectation that the blood will always be there when it is really needed. Blood donor volunteers constitute the main supply source in an effective blood supply chain management. They feed blood stocks through their donation. In an emergency situation, if the stocks are insufficient, the only source of blood supply will be the people who come to the health center and donate the blood on a voluntary basis. It is certain that time is a very important component in such ...

  5. A Systems Perspective on Volunteered Geographic Information

    OpenAIRE

    Victoria Fast; Claus Rinner

    2014-01-01

    Volunteered geographic information (VGI) is geographic information collected by way of crowdsourcing. However, the distinction between VGI as an information product and the processes that create VGI is blurred. Clearly, the environment that influences the creation of VGI is different than the information product itself, yet most literature treats them as one and the same. Thus, this research is motivated by the need to formalize and standardize the systems that support the creation of VGI. To...

  6. Virtual Mentoring for Volunteer Leadership Development

    OpenAIRE

    Guloy, Sheryl

    2015-01-01

    Calls to investigate leadership development in the nonprofit and voluntary sector have been put forth as concerns about leadership succession have increased. To respond to this call to investigate this under-researched area, this design-based, multiple case study provides rich, thick descriptions of the development of the mentoring relationships, between mentor and mentee pairs, over the course of a virtual mentoring program for volunteer leadership development, in a Catholic nonprofit. I exp...

  7. ATLAS@Home looks for CERN volunteers

    CERN Multimedia

    Rosaria Marraffino

    2014-01-01

    ATLAS@Home is a CERN volunteer computing project that runs simulated ATLAS events. As the project ramps up, the project team is looking for CERN volunteers to test the system before planning a bigger promotion for the public.   The ATLAS@home outreach website. ATLAS@Home is a large-scale research project that runs ATLAS experiment simulation software inside virtual machines hosted by volunteer computers. “People from all over the world offer up their computers’ idle time to run simulation programmes to help physicists extract information from the large amount of data collected by the detector,” explains Claire Adam Bourdarios of the ATLAS@Home project. “The ATLAS@Home project aims to extrapolate the Standard Model at a higher energy and explore what new physics may look like. Everything we’re currently running is preparation for next year's run.” ATLAS@Home became an official BOINC (Berkeley Open Infrastructure for Network ...

  8. Volunteer Motivations at a National Special Olympics Event

    Science.gov (United States)

    Khoo, Selina; Engelhorn, Rich

    2011-01-01

    Understanding the motivations for people to volunteer with the management and execution of major sporting events is important for the recruitment and retention of the volunteers. This research investigated volunteer motivations at the first National Special Olympics held in Ames, Iowa, USA in July 2006. A total of 289 participants completed the 28…

  9. Women Empower Women: Volunteers and Their Clients in Community Service

    Science.gov (United States)

    Kulik, Liat; Megidna, Hofit

    2011-01-01

    The study is aimed at examining the relationship between psychological empowerment of women volunteers and their clients in community volunteer projects in Israel. Based on an ecological approach, the study also aimed at examining whether the variables that explain empowerment of women who volunteer also explain empowerment of their clients. The…

  10. Motivations of Volunteer Leaders in an Extension Exercise Program

    Science.gov (United States)

    Washburn, Lisa T.; Cornell, Carol E.; Traywick, LaVona; Felix, Holly C.; Phillips, Martha

    2015-01-01

    This article describes findings from a qualitative study of volunteer leaders in the StrongWomen strength training program in Arkansas. The study explored reasons volunteers initially agreed to serve, perceptions of volunteer role, and motivations for continuing to lead strength training groups long-term. Findings suggest a combination of factors…

  11. Will Natural Resources Professionals Volunteer to Teach Youth?

    Science.gov (United States)

    Smith, Sanford S.; Finley, James C.; San Julian, Gary J.

    2010-01-01

    A unique approach to volunteer marketing research involved a mail survey with natural resources professionals from across Pennsylvania. Previous work identified this group as a source of potential volunteers for the 4-H youth natural resources program. The results give insights into those most likely to volunteer to teach youth through 4-H…

  12. Affecting Community Change: Involving "Pro Bono" Professionals as Extension Volunteers

    Science.gov (United States)

    Kelley, Diane T.; Culp, Ken, III

    2013-01-01

    "Pro bono" volunteers provide an effective means for Extension professionals to expand limited financial and human resources. Volunteers recruited from business settings can provide skills, abilities, expertise, leadership, and resources to Extension programs. Allowing professional volunteers to meet their desired leadership goals while…

  13. Assessing Changes in Virginia Master Gardener Volunteer Management

    OpenAIRE

    Dorn, Sheri T.

    1999-01-01

    ASSESSING CHANGES IN VIRGINIA MASTER GARDENER VOLUNTEER MANAGEMENT Sheri T. Dorn ABSTRACT Master Gardener (MG) volunteers are nonpaid, education partners with Virginia Cooperative Extension (VCE). VCE MGs have assisted Extension agents in meeting VCE's educational goals and mission by following the Sustainable Landscape Management educational program objectives within the VCE Plan of Work. Local MG volunteer programs must be managed appropriately so that vol...

  14. Development Situation and Countermeasure of Chinese Male Competitive Basketball%中国男子竞技篮球运动发展现状与对策研究

    Institute of Scientific and Technical Information of China (English)

    代勇

    2015-01-01

    采用文献资料、专家访谈、录像观察、比较分析等研究方法对中中国男子竞技篮球运动的发展历程做了整理与分析,结合08年北京奥运会、12年伦敦奥运会和第16届土耳其世锦赛中中国男篮与其对阵球队的各方面球员技术指标,了解当前中国男子竞技篮球的优势和不足之处,找出适用于目前中国男子篮球运动的发展规律,为训练和比赛提供理论依据。%This research mainly adopts the literature method, survey method, observation method, and mathematical statistics to analyze the development of the Chinese men's basketball. Combining with the skill indicators in the Olympic Games in 2008, 2012 and the World Championship in Turkey, the research attempts to explore the advantages and disadvantages of the Chinese men's basketball, and to figure out the appropriate development rule for the Chinese men's basketball, so as to provide proper theoretical basis for the races and training.

  15. Exercise increases endostatin in circulation of healthy volunteers

    Directory of Open Access Journals (Sweden)

    Makey Ian

    2004-01-01

    Full Text Available Abstract Background Physical inactivity increases the risk of atherosclerosis. However, the molecular mechanisms of this relation are poorly understood. A recent report indicates that endostatin, an endogenous angiostatic factor, inhibits the progression of atherosclerosis, and suggests that reducing intimal and atherosclerotic plaque tissue neovascularization can inhibit the progression atherosclerosis in animal models. We hypothesize that exercise can elevate the circulatory endostatin level. Hence, exercise can protect against one of the mechanisms of atherosclerosis. Results We examined treadmill exercise tests in healthy volunteers to determine the effect of exercise on plasma levels of endostatin and other angiogenic regulators. Oxygen consumption (VO2 was calculated. Plasma levels of endostatin, vascular endothelial growth factor (VEGF, and basic fibroblast growth factor (bFGF were determined using ELISA. The total peak VO2 (L in 7 male subjects was 29.5 ± 17.8 over a 4–10 minute interval of exercise. Basal plasma levels of endostatin (immediately before exercise were 20.3 ± 3.2 pg/ml, the plasma levels increased to 29.3 ± 4.2, 35.2 ± 1.8, and 27.1 ± 2.2 ng/ml, at 0.5, 2, and 6 h, respectively, after exercise. There was a strong linear correlation between increased plasma levels of endostatin (% and the total peak VO2 (L related to exercise (R2 = 0.9388; P Conclusions The results suggest that circulating endostatin can be significantly increased by exercise in proportion to the peak oxygen consumption under physiological conditions in healthy volunteers. These findings may provide new insights into the molecular links between physical inactivity and the risk of angiogenesis dependent diseases such as atherosclerosis.

  16. Individual and Social Predictors of Prosocial Behavior among Chinese Adolescents in Hong Kong.

    Science.gov (United States)

    Lai, Frank H Y; Siu, Andrew M H; Shek, Daniel T L

    2015-01-01

    Based on the human ecological model, this study hypothesized that individual competence in empathy, prosocial moral reasoning, and social influence from parents, peers, and school are the key determinants of prosocial behavior among Chinese adolescents in Hong Kong. We recruited a sample of high school students who engaged in volunteering activities regularly (N = 580). They completed a self-administrated questionnaire designed to measure prosocial behavior and its hypothesized predictors using a number of standardized instruments. The results of multiple regression show that social influence factors, including peer, school, and parent influence, are strong predictors of helping intention and prosocial behavior, while individual competence factors like empathy and prosocial moral reasoning are not. Male participants had higher empathy scores and helping intention than females, perceived their parents as more helpful, and their schools as more supportive of prosocial behavior. However, the significant predictors of prosocial behavior and helping intention were similar across gender. The findings indicate that social influence is strongly linked to prosocial behavior. This implies that socialization and social support for prosocial norms and behavior can exert a powerful influence on the behavior of young people in a Chinese population. PMID:26029684

  17. Widely Assumed but Thinly Tested: Do Employee Volunteers' Self-Reported Skill Improvements Reflect the Nature of Their Volunteering Experiences?

    OpenAIRE

    Jones, David A.

    2016-01-01

    An increasing number of companies use corporate volunteering programs (CVPs) to support and coordinate their employees' efforts to serve their communities. Among the most frequently touted benefits of such programs to sponsoring companies and employee volunteers alike is the opportunities for employees to develop tangible work-related skills through their volunteering activities. Evidence for skill development through volunteering, however, is mostly limited to the expressed beliefs of corpor...

  18. Why volunteer? : a case study of volunteers in the FIS Nordic World Ski Championship 2011 Oslo, Holmenkollen

    OpenAIRE

    Uchermann, Anette

    2011-01-01

    This thesis is a case study conducted on the volunteers in the FIS Nordic World Ski Championship 2011 in Oslo, Holmenkollen. The focus has been to study why the volunteers are motivated. I have investigated this through these following four research questions; (1) How does the volunteer’s degree of motivation develop during the WSC 2011?, (2) What motivates people to work as volunteers?, (3) How does volunteers feel about themselves? and (4) How will the volunteer’s expectation...

  19. Safety Evaluation of Crocin (a constituent of saffron Tablets in Healthy Volunteers

    Directory of Open Access Journals (Sweden)

    Amir Houshang Mohamadpour

    2013-01-01

    Full Text Available Objective(s: Crocin is the chemical ingredient primarily responsible for the color of saffron. It has different pharmacological effects such as antioxidant, anticancer and memory improving activities. Crocin tablets were evaluated for short-term safety and tolerability in healthy adult volunteers. Materials and Methods: The study was a randomized, double-blind, placebo-controlled design consisting of one month treatment of crocin tablets. Volunteers who fulfilled inclusion and exclusion criteria were randomized into 2 groups of 22 each (males and females and received 20 mg crocin tablets or placebo. General measures of health were recorded during the study such as hematological, biochemical, hormonal and urinary parameters in pre and post-treatment periods. Results: No major adverse events were reported during the trial. Crocin tablets did not change the above parameters except that it decreased amylase, mixed white blood cells and PTT in healthy volunteers after one month. Conclusion: This clinical safety evaluation showed a relatively safe and normal profile for crocin in healthy volunteers at the given doses within the trial period.

  20. Clinical Trials in Male Hormonal Contraception

    Directory of Open Access Journals (Sweden)

    Nieschlag E

    2011-01-01

    Full Text Available Research has established the principle of hormonal male contraception based on suppression of gonadotropins and spermatogenesis. All hormonal male contraceptives use testosterone, but only in East Asian men can testosterone alone suppress spermatogenesis to a level compatible with contraceptive protection. In Caucasians, additional agents are required of which progestins are favored. Clinical trials concentrate on testosterone combined with norethisterone, desogestrel, etonogestrel or depot-medroxyprogesterone acetate. The first randomized, placebo-controlled clinical trial performed by the pharmaceutical industry demonstrated the effectiveness of a combination of testosterone undecanoate and etonogestrel in suppressing spermatogenesis in volunteers.

  1. Widely Assumed but Thinly Tested: Do Employee Volunteers' Self-Reported Skill Improvements Reflect the Nature of Their Volunteering Experiences?

    Science.gov (United States)

    Jones, David A.

    2016-01-01

    An increasing number of companies use corporate volunteering programs (CVPs) to support and coordinate their employees' efforts to serve their communities. Among the most frequently touted benefits of such programs to sponsoring companies and employee volunteers alike is the opportunities for employees to develop tangible work-related skills through their volunteering activities. Evidence for skill development through volunteering, however, is mostly limited to the expressed beliefs of corporate leaders and employee volunteers. This study was designed to contribute to this largely anecdotal literature by testing hypotheses about the extent to which employee volunteers' self-reported skill development reflects the characteristics of the volunteers and their volunteering experiences. Study participants were 74 employee volunteers who completed a service apprenticeship managed by a U.S.-based nonprofit called Citizen Schools that partners with middle schools to extend the learning day with a combination of academic support, enrichment, and youth development activities. Data were obtained via the nonprofit's records, and surveys completed by employee volunteers before and after their service experience, including measures used to assess self-reported improvements in each of 10 work-related skills: communicating performance expectations, leadership, mentorship, motivating others, project management, providing performance feedback, public speaking and presenting, speaking clearly, teamwork, and time management. Support was found for several hypothesized effects suggesting that employees who practiced specific skills more often during their volunteering experience reported greater improvements in those skills. Improvements in some skills were higher among employee volunteers who completed a greater number of pre-volunteering preparation courses, and the effects of preparation courses were moderated by the employee volunteers' self-efficacy about improving their work

  2. Dietary Supplement with a Combination of Rhodiola Crenulata and Ginkgo Biloba Enhances the Endurance Performance in Healthy Volunteers

    Institute of Scientific and Technical Information of China (English)

    张樟进; 童瑶; 邹军; 陈佩杰; 虞定海

    2009-01-01

    Objective:To determine whether the ingestion of a herbal supplement called Rhodiola-Gingko Capsule(RGC) would enhance the endurance performance of healthy volunteers and change relevant hormones in a favorable manner.Methods:Seventy healthy male volunteers(age ranges from 18 to 22 years old) were randomly assigned to RGC group(35 cases,each capsule containing 270 mg herbal extracts,4 capsules per day) or placebo group(35 cases,equivalent placebo preparation) for 7 weeks using computerproduced digital ran...

  3. Common SNP in hsa-miR-196a-2 increases hsa-miR-196a-5p expression and predisposes to idiopathic male infertility in Chinese Han population

    OpenAIRE

    Jing Lu; Hao Gu; Qiuqin Tang; Wei Wu; Beilei Yuan; Dan Guo; Yongyue Wei; Hong Sun; Yankai Xia; Hongjuan Ding,; Lingqing Hu; Daozhen Chen; Jiahao Sha; Xinru Wang

    2016-01-01

    MicroRNA plays an important role in spermatogenesis. Whether pre-miRNAs polymorphisms are associated with idiopathic male infertility remains obscure. In this study, 1378 idiopathic infertile males and 486 fertile controls were included between 2006 and 2014. Genotype of three polymorphisms (hsa-mir-146a rs2910164, hsa-mir-196a-2 rs11614913, and hsa-mir-499 rs3746444) and expression of miRNA in seminal plasma were examined by TaqMan method. The role of hsa-miR-196a-5p in cell proliferation, a...

  4. Chinese Dream

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    The general managers of South Korean auto giants Hyundai and Kia have high hopes for the growing Chinese auto market. Both companies went through a painstaking period as the financial crisis first roared across the globe. Jin Shan-fa, General Manager of Hyundai Motor Group

  5. Fertility Inheritance of Cytoplasmic Male Sterile Line of Chinese Sorghum “Jinong 105”%中国高粱胞质雄性不育系“吉农105”育性遗传特性的研究

    Institute of Scientific and Technical Information of China (English)

    贾恩吉; 邓邵华; 陈兴平

    2000-01-01

    以中国高粱胞质雄性不育系“吉农105”为研究试材,用9个常用高粱恢复系与之杂交,并对其杂种后代F1、F2及BC1的育性分离比例进行了统计调查。结果表明:供试杂种在F1代全部表现育性恢复,在F2代发生了育性分离,其比例为可育:不育=3:1,同时在BC1代也发生了育性分离,其比例为可育:不育=1:1。根据孟德尔的遗传分离规律,可以推断控制“吉农105”的细胞核内的雄性不育基因为1对隐性基因。%The separation of fertility in F1, F2 and BC1 from crosses between cytoplasmic male sterile line of Chinese sorghum “Jinong 105” and 9 restoring lines of sorghum were statistically analysed. The results showed that the fertility of all hybrids in F1 were restored. However, F2 and BC1 segregated in fertility with respectively 3:1 and 1: 1 fertile to sterile ratio. This indicated that the male sterility of Chinese sorghum “Jinong 105” was controlled by a pair of recessive gene.

  6. 2008 LHC Open Days Training for volunteers

    CERN Document Server

    2008-01-01

    Information and training sessions are being organised for Open Day volunteers. The Open Days Organising Committee is offering information and training sessions every Thursday in March from 2.00 p.m. to 3.30 p.m. in the Main Building Auditorium. The first session will be on Thursday 6 March. It is important that volunteers attend these sessions to familiarise themselves with the practical arrangements for the two Open Days and with the main messages to be conveyed to the general public in order to make the event a success. General information will be given out at each session, followed by information on a specific theme. The sessions will be organised as follows: 2.00 - 2.45 p.m. : first part - general information 2.45 - 3.30 p.m. : second part - specific information * 6 March - specific theme "How to answer questions about the fears surrounding the LHC" * A different theme will be addressed at each session. The themes of subsequent sessions (13 , 20, 27 March and 3 Ap...

  7. BOINC service for volunteer cloud computing

    CERN Document Server

    Høimyr, N; Buncic, P; Giovannozzi, M; Gonzalez, A; Harutyunyan, A; Jones, P L; Karneyeu, A; Marquina, M A; Mcintosh, E; Segal, B; Skands, P; Grey, F; Lombraña González, D; Zacharov, I; CERN. Geneva. IT Department

    2012-01-01

    Since a couple of years, a team at CERN and partners from the Citizen Cyberscience Centre (CCC) have been working on a project that enables general physics simulation programs to run in a virtual machine on volunteer PCs around the world. The project uses the Berkeley Open Infrastructure for Network Computing (BOINC) framework. Based on CERNVM and the job management framework Co-Pilot, this project was made available for public beta-testing in August 2011 with Monte Carlo simulations of LHC physics under the name "LHC@home 2.0" and the BOINC project: "Test4Theory". At the same time, CERN's efforts on Volunteer Computing for LHC machine studies have been intensified; this project has previously been known as LHC@home, and has been running the "Sixtrack" beam dynamics application for the LHC accelerator, using a classic BOINC framework without virtual machines. CERN-IT has set up a BOINC server cluster, and has provided and supported the BOINC infrastructure for both projects. CERN intends to evolve the setup i...

  8. Do monetary rewards crowd out intrinsic motivations of volunteers? Some empirical evidence for Italian volunteers

    OpenAIRE

    Damiano Fiorillo

    2009-01-01

    The paper studies the determinants of regular volunteering departing from previous literature on extrinsic and intrinsic motivations. It contributes to the literature investigating the role of monetary rewards to influence intrinsic motivation. Using a simple framework that allows me to study the effect of monetary rewards on intrinsic motivation, the paper shows, controlling for endogenous bias, that monetary rewards crowd-out intrinsic motivation.

  9. CEBUANO PARA SA MGA PEACE CORPS VOLUNTEERS. (CEBUANO FOR THE PEACE CORPS VOLUNTEERS).

    Science.gov (United States)

    BAURA, BETTY; AND OTHERS

    THE BASIC VOCABULARY AND STRUCTURE OF CEBUANO VISAYAN ARE PRESENTED HERE THROUGH TWENTY-TWO SHORT DIALOGUES AND ACCOMPANYING PATTERN DRILLS AND CULTURAL NOTES. THE DIALOGUES ARE BASED ON EVERYDAY SITUATIONS AND COMMON USAGE THAT THE PEACE CORPS VOLUNTEER ENCOUNTERS IN THIS AREA OF THE PHILIPPINES. INTRODUCTORY PAGES PRESENT THE STUDENT WITH THE…

  10. MMPI Comparison of Black Heroin Users Volunteering or Not Volunteering for Treatment.

    Science.gov (United States)

    Robinowitz, R.; And Others

    1980-01-01

    Black volunteers differed significantly, scoring higher on the Hypochondriasis, Depression, and Hysteria scales. Such differences add evidence against the addiction-prone personality hypothesis and underscore the need for evaluating the effects of voluntarism and ethnicity in personality research on drug abuse. (Author)

  11. Volunteer Notes on Reforestation. A Handbook for Volunteers. Appropriate Technologies for Development. Reprint R-45.

    Science.gov (United States)

    Seefeldt, Steve, Comp.

    Provided in this document are descriptions of reforestation projects and techniques presented by Peace Corps volunteers from Chad, Ivory Coast, Upper Volta, and Niger. The purpose of the document is to aid individuals in trying to find solutions to the problems facing forestry in the Sahel. These projects include: (1) reforestation of Ronier palm…

  12. Volunteers: A Challenge For Extension Workers: Developing Volunteer Leaders From Disadvantaged Families.

    Science.gov (United States)

    Partin, Minerva O.; And Others

    A series of guidelines for use by Extension agents, as they involve socially and economically disadvantaged youth and adults in volunteer leadership roles in rural and urban Extension programs, is presented. Section headings are: Know Your Audience, Establish Rapport, Levels of Leadership, Leader Development, Leadership Roles, Volunteer…

  13. Male Osteoporosis

    Directory of Open Access Journals (Sweden)

    Meltem Esenyel

    2004-03-01

    Full Text Available Osteoporosis in men is now recognized as an increasingly important public health issue. About 30 % of hip fractures and 20 % of vertebral fractures occur in men. In the present study, we examined 19 men who did not have major risk factors that might affect bone mass. Parathormone(PTH, osteocalcin (marker of bone formation, OC and deoxypyridinoline (marker of bone resorption, DPD were measured. The bone mineral density (BMD measurements in 16 men were performed by dual-energy X-ray absorbtiometry (DXA from lumbar spine (L2-4, and left hip. Bone density at each site was categorized as osteoporosis or osteopenia according to World Health Organization (WHO criteria. In 19 patients with a mean age of 69 years, PTH levels were in the normal range except one patient. OC levels were elevated in %42.1 and DPD levels were elevated in 74 % of patients. L2-4 T score was osteoporotic (25% in 4 patients and osteopenic (25% in 4 patients. Femur Ward’s T score was osteoporotic (37.5% in 7 patients and osteopenic (37.5% in 7 patients. Osteoporosis is a significant problem in older men. Increased awareness for the risk factors of male osteoporosis is an important issue. Early diagnosis and treatment would help to reduce morbidity and mortality resulting from osteoporotic fractures.

  14. The role of nonprofessional volunteers in a Suicide Prevention Center.

    Science.gov (United States)

    Heilig, S M; Farberow, N L; Litman, R E; Shneidman, E S

    1968-08-01

    The procedures in the selection, training and supervision of 10 nonprofessional volunteers, to provide direct therapeutic crisis services to patients in a Suicide Prevention Center are described. One year's experience indicates a high degree of proficiency achieved by the volunteer in the handling of suicidal crises. The volunteers' reactions to the program are reported. Significant problems for the agency emerged in reference to precipitous increase in size of staff communication, and for the volunteer, in stimulation of problems of identity and selfconcept. The comments are limited to agency situations involving the use of nonprofessional volunteers in regular collaboration with a professional staff. Other models, such as entirely volunteer staffed groups, must be evaluated separately. PMID:24185391

  15. Study on Differences in Spermatogenic Suppression between Azoospermic and Oligozoospermic Responders Treated with Levonorgestrel Implant Plus Testosterone Undecanoate Injectable in Chinese Men

    Institute of Scientific and Technical Information of China (English)

    Si-tian LIU; You-lun GUI; W.J. Bremner; Er-sheng GAO; Chang-hai HE

    2003-01-01

    Objective To investigate possible causes resulting in the differences in the spermatogenesis suppression on individual treated with levonorgestrel (LNG) implants and testosterone undecanoate(TU) injectable Methods Totally 21 Chinese male volunteers were given treatment with LNG implants (four rods, 75 mg/rod) and intramuscular injection of TU (500 mg, bimonthly for 3 times). According to the effects of treatment, they were divided into two groups, namely, azoospermia group (group A) and oligozoospermia group (group 0). Then seminal FSH, LH, T and estradiol (E2)were determined by immunoenzymetric assay, while seminal and serum dihydrotachysterol (DHT)and serum sex hormone binding globulin (SHBG) were by radioimmunoassay, and seminal transferrin (Tf) by scatter turbidimetry assay.Results Seminal FSH, LH and serum DHT, SHBG, FTI (T/SHBG × 100) levels were significantly lower in group A than in group O, while higher seminal concentrations of E2 were observed in azoospermia group.Conclusion The differences in the spermatogenic suppression in Chinese men might be attributed to different rate of peripheral androgen metabolism, variations in serum SHBG levels,5a-reductase activity and individual aromatase activity during LNG plus TU administration. In addition, seminal sex hormones might be more sensitive indexes to assess the extent of feedback inhibition on hypothalamus-pituitary-testis with exogenous testosterone plus progestogen in the efficacy hormone male contraceptive trials.

  16. VOLUNTEERING AND LIFE SATISFACTION : AN INVESTIGATION OF ENDOGENEITY

    OpenAIRE

    CHEN, CHIANG-MING; YEH, CHIA-YU; CHANG, CHING-HSING

    2014-01-01

    Based upon the results of a national survey conducted in Taiwan, this study investigates the effects of volunteering on life satisfaction. We used a univariate ordered probit model and a simultaneous bivariate ordered probit model to compare the potential endogeneity between volunteering and life satisfaction. An exogenous military service variable was included in the bivariate model to correct the endogeneity of volunteering on life satisfaction. The results of the univariate ordered probit ...

  17. Court Appointed Volunteers for Abused and Neglected Children

    OpenAIRE

    Justin, Renate G.

    2002-01-01

    A court appointed special advocate (CASA) volunteer is a trained citizen who is appointed by a judge to represent the best interests of an abused and neglected child in court. An independent voice, the volunteer gathers information and reports to the court. The CASA volunteer works in close cooperation with other professionals, physicians, lawyers, social workers, and teachers to find the most suitable permanent placement for a victimized child, whether it be a foster home, parental home, or ...

  18. The consideration of emotional intelligence abilities in event volunteers

    OpenAIRE

    Reza Andam; Nooshin Benar; Mozhgan Aliabadi; Asieh Ghorbanian Rajabi; Ghorbanian A.; Kazem Danesh Sani

    2012-01-01

    The measurement of emotional intelligence abilities is one of the new subjects and important in human behavior studies. According to this matter, purpose of this research is consideration of emotional intelligence abilities in public sport events volunteers in 2011. For this purpose, Bradbury and Cruise's standard questionnaire was completed by present volunteers in event (n=80). The results indicated that 4 levels of emotional intelligence in volunteers are higher than expectational average ...

  19. Stavanger live festival from the viewpoint of volunteers

    OpenAIRE

    Novcic, Selena

    2014-01-01

    This paper is exploring selected organization process in Stavanger Live Festival from the point of view of volunteers as very sensitive group that must be handled by professionals. The areas that will be analyzed are process of recruitment, motivation and satisfactions of volunteers, quality and relevance of the training, quality of instruction and leadership, communications between volunteers and coordinators, support of the coordinators, expertise of the coordinators and top management, to ...

  20. An analysis of leadership characteristics of search and rescue volunteers

    OpenAIRE

    Gurer, Burak; ADILOGULLARI, Ilhan

    2015-01-01

    The main purpose of this study was to analyze the leadership behaviors of volunteer leaders in search and rescue field. 118 volunteer leaders attended this study on a volunteer basis. Data were collected through the use of the Multifactor Leadership Questionnaire, which was developed by Bass & Avolio (1985) and adapted into Turkish by Demir & Okan. 20 items were used to measure transformational leadership while 16 of them were applied for transactional leadership. One Way Anova and T-...

  1. 壮医的“公药”、“母药”与中医药学“对药”的内涵思考%Reflection on Connotation of “Male Herb” and “Female Herb” in Zhuang Nationality Medicine and “Matched Herb” of ;Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    唐汉庆; 黄岑汉; 黄秀峰; 李克明; 窦锡彬; 李晓华

    2015-01-01

    壮医药理论是壮族先民长期医疗实践经验的总结,具有浓郁的民族特色。“阴阳为本”是壮医药理论体系的重要组成部分。“公药”、“母药”的配伍以壮医阴阳思想为指导,配伍规律有主药配主药、主药配帮药、主药配带药、主药配解毒药,这与中药“对药”的配伍应用既相类似也有差异。通过总结相关“公药”、“母药”的应用实践经验,与中药“对药”的配伍应用进行比较,进一步认识“公药”、“母药”与“对药”的学术内涵。加强壮医药与中医药的交流,使两者相互借鉴,更好地指导临床工作。%Zhuang people have accumulated and summarized lots of medicine knowledge in long time of practice , which is characterized with Zhuang nationality .“Yin‐Yang thoughts”is an important part of Zhuang nationality medicine theory ,which is the guide of combination of “male herb” and “female herb” .There are some rules about the combination of “male herb” and“female herb”such as combination of main herb and main herb ,combination of main herb and auxiliary herb ,combination of main herb and guide herb ,combination of main herb and detoxify herb ,to which the rules of combination of “matched herb” of Traditional Chinese Medicine are similar .Meanwhile ,there is difference between them .Comparing the difference will promote better understnding of the academic value of “male herb”,“female herb” and “matched herb”,and provide better guidance for clinical application of Zhuang nationality medicine with more communication and reference with Traditional Chinese Medicine .

  2. Chinese restaurant syndrome

    Science.gov (United States)

    Chinese restaurant syndrome is a set of symptoms that some people have after eating Chinese food. A food additive ... Chinese restaurant syndrome is most often diagnosed based on the symptoms. The health care provider may ask the following ...

  3. CHINESE JOURNAL OF CHEMISTRY

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    @@Chinese Journal of Chemistry is an international journal published in English by the Chinese Chemical Society with its editorial office hosted by Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences.

  4. Chinese Culture and Leadership.

    Science.gov (United States)

    Wong, Kam-Cheung

    2001-01-01

    Describes essential characteristics of Chinese philosophical tradition; Discusses Western perspectives on value leadership in education, particularly moral leadership. Discuses moral leadership from a Chinese philosophical perspective, especially Confucianism. Draws implications for using Chinese cultural and philosophical traditions to develop…

  5. Networking for philanthropy: increasing volunteer behavior via social networking sites.

    Science.gov (United States)

    Kim, Yoojung; Lee, Wei-Na

    2014-03-01

    Social networking sites (SNSs) provide a unique social venue to engage the young generation in philanthropy through their networking capabilities. An integrated model that incorporates social capital into the Theory of Reasoned Action is developed to explain volunteer behavior through social networks. As expected, volunteer behavior was predicted by volunteer intention, which was influenced by attitudes and subjective norms. In addition, social capital, an outcome of the extensive use of SNSs, was as an important driver of users' attitude and subjective norms toward volunteering via SNSs. PMID:24102569

  6. Sport volunteerism: a study on volunteering motivations in university students

    Directory of Open Access Journals (Sweden)

    HAMIDREZA MIRSAFIAN

    2012-03-01

    Full Text Available Volunteers form an integral part of the sport industry. Recognition of the volunteers' motivations to attract them in sport programs is the aim of each organization. Although several studies have been conducted regarding volunteers in sport, there is not a clear idea about the effective motivational factors on the sport volunteers on different communities. This subject might be due to the effects of social variables on the volunteering motivations. The aim of this study was to analyze the motivational factors in university sport. The samples consist all of the 304 students who participated as volunteers in sport programs at the Iranian universities. For data collection, a structured questionnaire comprising 39 items in the form of seven different factors (material, social, career supportive, purposive, progress and obligation regarding the motivational factors of sport volunteering was used. The items in the questionnaire were scored on a 5-point Likert-type scale. This study demonstrated that the social and obligation factors were the highest and lowest effective factors on the sport volunteers’ motivation. Also, there was a significant difference between the effect of social and career factors in two genders (P<0.05. This means that boys and girls had higher scores in career and social factors. In conclusion it is stated that university students have a large impact on the general ideas at the communities; therefore, promotion of sport volunteering activities at the universities could develop the culture of volunteering in various parts of the communities.

  7. The role of the hospice volunteer in community settings

    OpenAIRE

    Draper, Janet; Kernohan, George; McNamara, Aine; Komaromy, Carol

    2014-01-01

    In the UK, there are between 70,000 and 100,000 hospice volunteers, of whom half have direct patient contact. This seminar draws on a commissioned literature review that highlighted how ‘volunteering is integral to voluntary action and often motivated by altruism.’ The review concluded that hospice at home volunteers can help improve the quality of responsiveness of end of life care, improve access to care and can support care and death in the person’s own home. Volunteers gain health and soc...

  8. Male Reproductive System

    Science.gov (United States)

    ... I Help a Friend Who Cuts? Male Reproductive System KidsHealth > For Teens > Male Reproductive System Print A ... reproductive systems. continue What Is the Male Reproductive System? Most species have two sexes: male and female. ...

  9. AVOCLOUDY: a simulator of volunteer clouds

    DEFF Research Database (Denmark)

    Sebastio, Stefano; Amoretti, Michele; Lluch Lafuente, Alberto

    2015-01-01

    , with the purpose to ‘green’ them. Indeed, the combination of data center and volunteer resources, managed by agents, allows one to obtain a more robust and scalable cloud computing platform. The increased challenges in designing such a complex system can benefit from a simulation-based approach, to test autonomic...... management solutions before their deployment in the production environment. However, currently available simulators of cloud platforms are not suitable to model and analyze such heterogeneous, large-scale, and highly dynamic systems. We propose the AVOCLOUDY simulator to fill this gap. This paper presents...... the internal architecture of the simulator, provides implementation details, summarizes several notable applications, and provides experimental results that measure the simulator performance and its accuracy. The latter experiments are based on real-world worldwide distributed computations on top of the Planet...

  10. A Systems Perspective on Volunteered Geographic Information

    Directory of Open Access Journals (Sweden)

    Victoria Fast

    2014-12-01

    Full Text Available Volunteered geographic information (VGI is geographic information collected by way of crowdsourcing. However, the distinction between VGI as an information product and the processes that create VGI is blurred. Clearly, the environment that influences the creation of VGI is different than the information product itself, yet most literature treats them as one and the same. Thus, this research is motivated by the need to formalize and standardize the systems that support the creation of VGI. To this end, we propose a conceptual framework for VGI systems, the main components of which—project, participants, and technical infrastructure—form an environment conducive to the creation of VGI. Drawing on examples from OpenStreetMap, Ushahidi, and RinkWatch, we illustrate the pragmatic relevance of these components. Applying a system perspective to VGI allows us to better understand the components and functionality needed to effectively create VGI.

  11. A Study to Draw a Normative Database of Laryngopharynx pH Profile in Chinese

    OpenAIRE

    Feng, Guijian; Wang, Junyao; Zhang, Lihong; Liu, Yulan

    2014-01-01

    Background/Aims To draw a normative database of laryngopharynx pH profile in Chinese subjects. Methods Normal volunteers were recruited from “www.Ganji.com” and People’s hospital between May 2008 and December 2009. The Restech pH Probes were calibrated in pH 7 and pH 4 buffer solutions according to the manufacturer's instructions. Each volunteer was asked to wear the device for a 24-hour period and was encouraged to participate in normal daily activities. Results The healthy volunteers consis...

  12. The Chinese Banking System

    OpenAIRE

    Grant Turner; Nicholas Tan; Dena Sadeghian

    2012-01-01

    The Chinese banking system is critical to the functioning of the Chinese economy, being the main conduit through which savings are allocated to investment opportunities. Banking activity in China has grown rapidly over the past decade in association with the expansion of the Chinese economy, and the Chinese banking system now includes some of the world’s largest banks. Chinese banks have become more commercially orientated over this period, although the Chinese Government retains considerable...

  13. Communication and relationship satisfaction in Chinese, Western, and intercultural Chinese-Western couples.

    Science.gov (United States)

    Hiew, Danika N; Halford, W Kim; van de Vijver, Fons J R; Liu, Shuang

    2016-03-01

    The current study compared Chinese, Western, and intercultural Chinese-Western couples' communication and examined how culture moderates the association of communication with relationship satisfaction. We coded the communication of 33 Western couples, 36 Chinese couples, and 54 intercultural Chinese-Western couples when discussing a relationship problem and when reminiscing about positive relationship events. Couples with Chinese female partners showed fewer positive behaviors and more negative behaviors (as classified in existing Western coding systems) than couples with Western female partners. The male partner's culture had few associations with couples' rates of communication behavior. Relationship satisfaction was associated with low rates of negative behaviors and high rates of most of the positive behaviors across cultural groups, and these associations were more evident in problem discussions than positive reminiscences. PMID:26371449

  14. The Interface of Volunteer Work and Paid Work : Benefits of Volunteering for Working Life

    OpenAIRE

    Mojza, Eva J.

    2008-01-01

    Increasingly, psychologists are dealing with the research question of how different life domains are positively related to each other. While the focus is currently on the interface of family and work (e.g., theories and studies on the positive relationship between family engagement and work engagement; Greenhaus & Powell, 2006; Grzywacz et al., 2006; Rohtbard, 2001), until now the interface of volunteer work and paid work has rarely been scrutinized. However, there is empirical evidence (Kirc...

  15. Students’ motivations for volunteering : a study on the motivational factors for volunteering in student unions

    OpenAIRE

    Skramstad, Martin Roa

    2014-01-01

    The objective of this thesis is to uncover the main motivations for, and hindrances against, student volunteer work, and to understand what it is that gives satisfaction from participation for the students. In order to solve the objective, analyses are performed on collected data from students at NHH in Norway and at Tecnológico de Monterrey in Mexico. The analyses show connections between control variables and ten different motivational factors and five different hindrance factors, as wel...

  16. Body Image Concerns in College-Aged Male Physical Education Students: A Descriptive Inquiry

    Science.gov (United States)

    Olson, Michele S.; Esco, Michael R.; Willifo, Hank

    2009-01-01

    The purpose of this study was to examine body image concerns in college-aged male physical education majors. Sixty volunteers completed validated body image instruments including two-dimensional figure drawings. In general, the sample reported that they preferred a larger, more muscular physique reflective of male images that currently abound the…

  17. Motives in Sexual Aggression: The Chinese Context.

    Science.gov (United States)

    Tang, Catherine So-Kum; And Others

    1993-01-01

    Compared sexual and aggressive motives for sexual aggression in Chinese college students. Male undergraduates (N=146) completed self-report measures. Results suggest that sex guilt and aggressive guilt acted as inhibitors for their respective drives and sexual aggression resulted from aggressive, rather than sexual, motives. Sexual aggression may…

  18. Measuring the volume of temporal lobe in healthy Chinese adults of the Han nationality on the high-resolution MRI

    International Nuclear Information System (INIS)

    Objective: To explore the morphological features of temporal lobe of healthy Chinese Han adults on the high-resolution MRI and provide morphological data of temporal lobe for the construction of database for Chinese Standard Brain. Methods: This is a clinical multi-center study. Three hundred healthy Chinese volunteers (male 150, and female 150) recruited from 15 hospitals were divided equally into five groups according to their age, i.e., 18-30 (Group A), 31-40 (Group B), 41-50 (Group C), 51- 60(Group D), 61-70(Group E). All subjects were scanned using T1WI 3D MPRAGE sequence and volumes of standardized temporal lobe were collected. The bilateral volumes of standardized temporal lobe were compared by variance analysis between male and female subjects and among five age groups. Results: The mean volumes of left and right temporal lobe were (97 126±15 703) mm3 and (97 015 ± 15 545) mm3 respectively for men, and (95 123 ± 14 564) mm3 and (96 423 ± 13 407) mm3 for women. The difference temporal lobe volume between male and female wasn't significant on the same side (F=1.336, 0.127, P= 0.249, 0.722). The left temporal lobe volumes of Group A-E were (93 873±13 351), (95 566± 11 964), (10 1890 ± 14 511), (93 972 ± 14 050) and (95 636 ± 19 864) mm3 respectively, and those on the right side were (93 409 ± 10 984), (98 158 ± 16 392), (102 079 ± 15 112), (95 448 ± 11 123) and (94 658 ± 16 928) mm3. There were significant differences among 5 groups between left and right temporal lobe volume(F=2.940, 3.514, P=0.021, 0.008). Further pairwise comparison revealed that left and right temporal lobe volume in Group C is higher than those of Group A and D (P0.05). Conclusion: High-resolution MRI could offer detailed images and precise morphological data of temporal lobe, which provides morphological data of temporal lobe for the construction of database for Chinese Standard Brain. (authors)

  19. A comparative study of dietary intake among urban Japanese and Chinese aged 50∼79

    OpenAIRE

    Wang,Da-Hong; Li, Jiong; Kira, Shohei

    2000-01-01

    This study examined the difference in dietary intake between middle-aged and elderly Japanese and Chinese. Volunteers aged 50–79 living in two cities in both Japan and China were recruited in local community service centers and were asked to complete a 3-day diet recording. The final results were based on 356 subjects (166 Chinese and 190 Japanese). In men, the Japanese subjects significantly consumed more energy, with a large proportion of the energy coming from carbohydrates, dietary fiber,...

  20. Chinese Calendar and Chinese Telegraphic Code.

    Science.gov (United States)

    Defense Language Inst., Monterey, CA.

    This manual contains: (1) Chinese calendars for the hundred years from 1881 to 1980; and (2) the Chinese telegraphic code. Each page in Part One presents the calendar for each year in both Chinese and English. There are 97 charts in Part Two representing the telegraphic code. (AMH)

  1. Connecting Volunteers and Agents: A Social Constructionist Perspective

    Science.gov (United States)

    Dillivan, K. D.

    2013-01-01

    Extension volunteers benefit from participation in training activities. Furthermore, Extension personnel are best positioned to provide volunteers with relevant training. However, trainers neglecting relationship building and failing to attend to the communicative process may achieve unsatisfactory results. Social constructionism, a theoretical…

  2. Pressure pain thresholds in volunteers and herniorrhaphy patients

    DEFF Research Database (Denmark)

    Dahl, J B; Rosenberg, J; Molke Jensen, F; Kehlet, H

    1990-01-01

    surgery. PPT was determined in 20 healthy volunteers on two separate examinations, and in 14 patients at the incisional site before and following inguinal herniotomy. In volunteers, PPT was higher for men than for women, and no difference was observed between the first and second day of examination. In...

  3. Volunteers as Products of a Zoo Conservation Education Program

    Science.gov (United States)

    Bixler, Robert D.; Joseph, Stephanie L.; Searles, Vicki M.

    2014-01-01

    Zoos embrace docents/volunteers as a means of interpreting the threats to wildlife and biodiversity to visitors. To accomplish this, zoos provide docents' education, training, and work experience. Docents themselves also engage in solitary and social wildlife experiences outside of their volunteer obligations. This study examined what…

  4. Three Steps to Engage Volunteers in Membership Marketing

    Science.gov (United States)

    Rossell, Tony

    2011-01-01

    There is a big world out there, and volunteers can make a significant impact in helping one reach out to others and grow his/her PTA membership. In fact, word-of-mouth marketing tied for the top spot as the most effective method of new member recruitment in Marketing General's 2010 Membership Marketing Benchmarking Report. So getting volunteers'…

  5. Measuring the volume of insula in healthy Chinese adults of the Han nationality on the high-resolution MRI

    International Nuclear Information System (INIS)

    Objective: To explore the normal range of the insula volume of Chinese adults of the Hah nationality and its relationship with age, which provide morphological data for the construction of database for Chinese Standard Brain. Methods: This is a clinical multi-center study. One thousand Chinese healthy volunteers (age range = 18 to 70) recruited from 16 hospitals were divided into 5 groups, i.e., Group A (age range =18 to 30), B (age range =31 to 40), C (age range =41 to 50), D (age range = 51 to 60), and E (age range = 61 to 70). Each group contained 100 males and 100 females. All of the volunteers were scanned by MR using T1 weighted three-dimensional magnetization prepared rapid acquisition gradient echo sequence. After three dimension data reconstruction, the volumes of bilateral insula were manually measured. The volume of bilateral insula were compared by paired sample t test. The insula volumes were compared between male and female by independent sample t test, and the differences among 5 age groups were compared by one-way ANNOVA. The relationship between the volumes of insula and age, sex or cerebral volume were analyzed using bivariate correlation, respectively. Results: The left and right side volume of insula before standarized were (7764 ± 1165) and (7387 ± 1128) mm3 respectively, after standarized were (8413 ± 1201) and (7871 ± 1140) mm3 respectively. The left insula volume were significant larger than that of fight (t=-10.565, -16.014, P3 for male, and (7393 ± 1022) mm3 and (7050 ± 1038) mm for female. The left and right insula volumes for male were larger than the female's (t=10.934,9.945,P3, female were (8043± 1054) and (7515 ± 1091 ) mm3, the left and right insula volume of male were larger than the female's(t=4.858,4.632,P3 respectively, the right were (8028 ± 1156), (7636 ± 1075), (7294 ± 986) (7249 ± 1068), (6717 ± 916) mm3 respectively, there were significant differences among 5 groups between left and right insula volume (F= -0

  6. 广东省志愿服务国际化的调查分析%Research and Analysis of the Internationalization of Guangdong Volunteer Service

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    广东志愿服务需要通过国际交流合作不断融入世界。一方面,吸收各国现代志愿服务发展理念和经验,丰富我国志愿服务的内容与形式;另一方面,通过志愿服务国际合作向世界传播中国的核心价值观,提升国家竞争软实力。广东珠江三角洲地区作为中国改革开放前沿和志愿服务的发源地之一,再次率先探索国际化途径,包括构建“一会两院三基地”的国际合作格局,将引进和借鉴国际志愿服务发展理念、向世界传播中国核心价值观、提升民间志愿组织服务能力、普及低碳环保生活方式、培育青年志愿者领袖国际参与素质、塑造中国现代化城市发展的国际形象等作为合作内容。%Through international exchanges and cooperation, Guangdong volunteer service will gradually integrate into the world. On one hand, it absorbs the developing ideas and experience of modern volunteer service in different counties to enrich the contents and forms of volunteer service in China; on the other hand, it spreads Chinese core value to the world through international cooperation to enhance national soft power competition. As the forefront of reform and opening and one of the birthplaces of volunteer service in China, Guangdong Pearl River Delta Region takes the lead in exploring the paths of internationalization once again, including constructing an international cooperation framework of "one office, two colleges and three bases". It will introduce and learn from international volunteer service development ideas, spread Chinese core value to the whole world, improve the ability of non-government volunteer service organizations, popularize low carbon lifestyle, cultivate the quality of youth participation among youth volunteer leaders and shape the international image of China modernized city development. In this way, provide a basis for Chinese volunteer service to go towards the world and play the

  7. Predicting professional quality of life among professional and volunteer caregivers.

    Science.gov (United States)

    Avieli, Hila; Ben-David, Sarah; Levy, Inna

    2016-01-01

    This study is one of the few that has compared volunteers' professional quality of life (PQL), which includes secondary traumatic stress (STS), burnout, and compassion satisfaction (CS), to those of professional caregivers. In addition, the research compared the ethical behavior of volunteers with that of professional therapists and examined the connection between years of experience, ethical behavior, and PQL. One hundred eighty-three volunteers and professional caregivers filled out a sociodemographic questionnaire, an Ethical Behavior Questionnaire and the Professional Quality of Life (ProQOL) questionnaire. The results indicated that professional caregivers report lower levels of STS and burnout, and higher levels of CS and ethical behavior compared with volunteer caregivers. Moreover, the findings suggest that ethical behavior correlates with STS, burnout, and CS. Ethical behavior has a protective value for mental health caregivers. The discussion emphasizes the value of a professional code of ethics and ethical training for professional and volunteering caregivers. PMID:26121172

  8. English Training for College Student Volunteers at Sports Events

    Institute of Scientific and Technical Information of China (English)

    LIU Wei

    2014-01-01

    This paper studies English training for student volunteers at large scale sports events with a comprehensive investigation of the undergraduate student volunteers from Capital University of Physical Education who have taken part in large scale sports events. By examining the current volunteer training situation, the author finds that there is a sever lack of professional and system-atical English training for student volunteers at large scale sports events. The study shows focusing on sports events knowledge and requirements of the volunteers’specific job is crucial to the service level of the volunteers. The study concludes that the problem can be solved by developing new course books, innovating new flexible training methods, and offering more comprehensive training content. The recommended training methods include intensive group training, computer aided teaching, task training and on-the-spot training to make them fit their work soon.

  9. Volunteer Clouds and Citizen Cyberscience for LHC Physics

    International Nuclear Information System (INIS)

    Computing for the LHC, and for HEP more generally, is traditionally viewed as requiring specialized infrastructure and software environments, and therefore not compatible with the recent trend in volunteer computing, where volunteers supply free processing time on ordinary PCs and laptops via standard Internet connections. In this paper, we demonstrate that with the use of virtual machine technology, at least some standard LHC computing tasks can be tackled with volunteer computing resources. Specifically, by presenting volunteer computing resources to HEP scientists as a volunteer cloud, essentially identical to a Grid or dedicated cluster from a job submission perspective, LHC simulations can be processed effectively. This article outlines both the technical steps required for such a solution and the implications for LHC computing as well as for LHC public outreach and for participation by scientists from developing regions in LHC research.

  10. The Effects of Fifa 2015 Computer Games on Changes in Cognitive, Hormonal and Brain Waves Functions of Young Men Volunteers

    OpenAIRE

    Aliyari, Hamed; Kazemi, Masoomeh; Tekieh, Elaheh; Salehi, Maryam; Sahraei, Hedayat; Daliri, Mohammad Reza; Agaei, Hassan; Minaei-Bidgoli, Behrouz; Lashgari, Reza; Srahian, Nahid; Hadipour, Mohammad Mehdi; Salehi, Mostafa; Ranjbar Aghdam, Asghar

    2015-01-01

    Introduction: Computer games have attracted remarkable attentions in general publics with different cultures and their effects are subject of research by cognitive neuroscientists. In the present study, possible effects of the game Fifa 2015 on cognitive performance, hormonal levels, and electroencephalographic (EEG) signals were evaluated in young male volunteers. Methods: Thirty two subjects aged 20 years on average participated mutually in playing computer game Fifa 2015. Identification in...

  11. Volunteer Bias in Sex Research: The effect of recruitment material on demographics, personality, impression management, sociosexuality, sexual desire and preoccupation

    OpenAIRE

    Hope, David

    2008-01-01

    The study investigated volunteer bias in sex research across different measures in an online anonymous environment. 108 participants (79 female, 29 male) participated, completing one of two versions. Version A participants were recruited to a personality and sexual research study. Version B participants were recruited to a personality study then asked to continue to a sexual research study. Condition significantly impacted age but the effect was small. Condition did not affect sexual behaviou...

  12. Evaluation of the self-inflating bag-valve-mask and non-rebreather mask as preoxygenation devices in volunteers

    OpenAIRE

    Robinson, Amelia; Ercole, Ari

    2012-01-01

    Objective To evaluate and compare the effectiveness and tolerability of preoxygenation with the self-inflating bag-valve-mask (BVM) and non-rebreather mask (NRM) as are used before emergency anaesthesia. Design Device performance evaluation. Setting Experimental study. Participants 12 male and 12 female healthy volunteers (age range 24–47) with no history of clinically significant respiratory disease. Interventions End-expiration oxygen measurements (FEO2) after 3 min of preoxygenation with B...

  13. Association of Sarcopenic Obesity with Higher Serum High-Sensitivity C-Reactive Protein Levels in Chinese Older Males--A Community-Based Study (Taichung Community Health Study-Elderly, TCHS-E.

    Directory of Open Access Journals (Sweden)

    Chuan-Wei Yang

    Full Text Available The prevalence of obesity and sarcopenia is high among the elderly. The simultaneous occurrence of these two disorders results in sarcopenic obesity. Research suggests that inflammation has an important role in the pathogenesis of obesity and sarcopenia. This study explores the impact of sarcopenic obesity on inflammatory markers, including interleukin-6 (IL-6, high-sensitivity C-reactive protein (hs-CRP, and tumor necrosis factor-alpha (TNF-α. This study is a community-based cross-sectional study. The study sample consisted of 844 community-dwelling people aged 65 years and older (448 men and 396 women. Sarcopenia was characterized by low muscle mass (skeletal muscle index < 6.87 and 5.46 kg/m2 for men and women, respectively, and obesity was characterized by excess body fat (body fat percentage greater than the 60th percentile of the study sample by sex [27.82% in men and 37.61% in women]. Older individuals identified with sarcopenic obesity were those who had both sarcopenia and obesity. Inflammatory markers such as IL-6, hs-CRP, and TNF-α were measured. The prevalence rates of obesity only, sarcopenia only, and sarcopenic obesity were 32.94%, 11.85%, and 7.23%, respectively. No difference was observed in the serum levels of IL-6 and TNF-α among the four groups of combined sarcopenia and obesity status. After multivariate adjustment, the serum hs-CRP levels in the obesity only and in the sarcopenic obesity groups were 0.14 and 0.16 mg/dL among males, respectively, which were significantly higher than that in the normal group (P=0.012 and 0.036. Our results provide evidence that obesity and sarcopenic obesity are associated with increased levels of serum hs-CRP among males.

  14. Association of Sarcopenic Obesity with Higher Serum High-Sensitivity C-Reactive Protein Levels in Chinese Older Males--A Community-Based Study (Taichung Community Health Study-Elderly, TCHS-E).

    Science.gov (United States)

    Yang, Chuan-Wei; Li, Chia-Ing; Li, Tsai-Chung; Liu, Chiu-Shong; Lin, Chih-Hsueh; Lin, Wen-Yuan; Lin, Cheng-Chieh

    2015-01-01

    The prevalence of obesity and sarcopenia is high among the elderly. The simultaneous occurrence of these two disorders results in sarcopenic obesity. Research suggests that inflammation has an important role in the pathogenesis of obesity and sarcopenia. This study explores the impact of sarcopenic obesity on inflammatory markers, including interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), and tumor necrosis factor-alpha (TNF-α). This study is a community-based cross-sectional study. The study sample consisted of 844 community-dwelling people aged 65 years and older (448 men and 396 women). Sarcopenia was characterized by low muscle mass (skeletal muscle index obesity was characterized by excess body fat (body fat percentage greater than the 60th percentile of the study sample by sex [27.82% in men and 37.61% in women]). Older individuals identified with sarcopenic obesity were those who had both sarcopenia and obesity. Inflammatory markers such as IL-6, hs-CRP, and TNF-α were measured. The prevalence rates of obesity only, sarcopenia only, and sarcopenic obesity were 32.94%, 11.85%, and 7.23%, respectively. No difference was observed in the serum levels of IL-6 and TNF-α among the four groups of combined sarcopenia and obesity status. After multivariate adjustment, the serum hs-CRP levels in the obesity only and in the sarcopenic obesity groups were 0.14 and 0.16 mg/dL among males, respectively, which were significantly higher than that in the normal group (P=0.012 and 0.036). Our results provide evidence that obesity and sarcopenic obesity are associated with increased levels of serum hs-CRP among males. PMID:26177029

  15. Volunteers and Ex-Volunteers: Paths to Civic Engagement Through Volunteerism Voluntarios y Ex Voluntarios: Perfiles de Participación Ciudadana a Través del Voluntariado

    Directory of Open Access Journals (Sweden)

    Elena Marta

    2010-11-01

    Full Text Available The study described is part of a broader longitudinal and multi-methodological research project aimed at investigating volunteerism in young people, in order to understand the reasons for the initial choice to volunteer but, more specifically, the reasons to sustain or quit voluntary involvement, as well as the effects of volunteerism. Eighteen volunteers and 18 ex-volunteers, 50% male and 50% female, aged between 22 and 29 years old, from 2 regions in northern Italy (Lombardy and Emilia Romagna participated in in-depth interviews. The paper-and-pencil analysis of the interview pointed to the emergence of several core categories: motivations to volunteer, relations within the organization, influence of family, and effects of volunteerism, especially as related to the process of identity and citizenship construction. On the basis of these categories, 4 typologies were identified: 2 with respect to volunteers (producers of active citizenship and volunteers for personal necessity and 2 related specifically to ex-volunteers (ex-volunteers witnesses for solidarity and active citizenship and ex-volunteers by chance.El estudio descrito es parte de un proyecto de investigación longitudinal y multi-metodológico más amplio sobre el voluntariado juvenil, realizado con el propósito de entender las razones que tuvieron los jóvenes para elegir el voluntariado y, específicamente, las razones para mantener o abandonar el compromiso, así como los efectos de dicho voluntariado. Participaron en entrevistas en profundidad 18 voluntarios y 18 ex-voluntarios, 50% hombres y 50% mujeres, entre 22 y 29 años de edad, de 2 regiones del norte de Italia (Lombardía y Emilia Romagna. El análisis de la entrevista de lápiz y papel permitió trazar varias categorías centrales: las motivaciones al voluntariado, las relaciones dentro de la organización, la influencia de la familia y los efectos del propio voluntariado, especialmente en relación con el proceso de

  16. Chronic cigarette smoking alters erythrocyte membrane lipid composition and properties in male human volunteers.

    Science.gov (United States)

    Padmavathi, Pannuru; Reddy, Vaddi Damodara; Kavitha, Godugu; Paramahamsa, Maturu; Varadacharyulu, Nallanchakravarthula

    2010-11-01

    Cigarette smoking is a major lifestyle factor influencing the health of human beings. The present study investigates smoking induced alterations on the erythrocyte membrane lipid composition, fluidity and the role of nitric oxide. Thirty experimental and control subjects (age 35+/-8) were selected for the study. Experimental subjects smoke 12+/-2 cigarettes per day for 7-10 years. In smokers elevated nitrite/nitrate levels in plasma and red cell lysates were observed. Smokers showed increased hemolysis, erythrocyte membrane lipid peroxidation, protein carbonyls, C/P ratio (cholesterol and phospholipid ratio), anisotropic (gamma) value with decreased Na(+)/K(+)-ATPase activity and sulfhydryl groups. Alterations in smokers erythrocyte membrane individual phospholipids were also evident from the study. Red cell lysate nitric oxide positively correlated with C/P ratio (r=0.565) and fluorescent anisotropic (gamma) value (r=0.386) in smokers. Smoking induced generation of reactive oxygen/nitrogen species might have altered erythrocyte membrane physico-chemical properties. PMID:20561918

  17. Central nervous system effects of haloperidol on THC in healthy male volunteers

    NARCIS (Netherlands)

    Liem-Moolenaar, Marieke; te Beek, Erik T; de Kam, Marieke L; Franson, Kari L; Kahn, René S; Hijman, Ron; Touw, Daan; van Gerven, Joop M A

    2010-01-01

    In this study, the hypothesis that haloperidol would lead to an amelioration of Δ9-tetrahydrocannabinol (THC)-induced 'psychotomimetic' effects was investigated. In a double-blind, placebo-controlled, partial three-way crossover ascending dose study the effects of THC, haloperidol and their combinat

  18. Functional magnetic resonance imaging investigation of the amphetamine sensitization model of schizophrenia in healthy male volunteers

    OpenAIRE

    O'Daly, Owen G; Joyce, Daniel; Stephan, Klaas E.; Murray, Robin M G; Shergill, Sukhwinder S.

    2011-01-01

    These transient load-dependent abnormalities of frontal and temporal activity induced by amphetamine sensitization support neuroimaging findings in schizophrenic patients, implying that amphetamine sensitization may help to bridge pathophysiological theories of schizophrenia that focus on pharmacological (dopaminergic) and cognitive mechanisms, respectively.

  19. Pharmacokinetics of bacmecillinam and pivmecillinam in volunteers.

    Science.gov (United States)

    Josefsson, K; Bergan, T; Magni, L; Pring, B G; Westerlund, D

    1982-01-01

    The pharmacokinetics of bacmecillinam and pivmecillinam were studied in healthy fasting volunteers given tablets in a cross-over, randomized order. The mean (+/- SD) peak levels of plasma mecillinam were 1.43 +/- 0.34, 2.73 +/- 0.43, and 4.62 +/- 1.41 mg/l after bacmecillinam 100, 200, and 400 mg and 2.38 +/- 0.65 mg/l after pivmecillinam 400 mg. The corresponding areas under plasma Vs time curves (AUC) were 2.21 +/- 0.19, 3.99 +/- 0.63, and 7.74 +/- 1.38 mg . h. l-1 for bacmecillinam and 5.35 +/- 0.93 mg . h. l-1 for pivmecillinam. The elimination half-lives were 0.8-1.1 h for bacmecillinam and 0.7 h for pivmecillinam. The 12 h urinary recovery of unchanged mecillinam after the 400 mg doses was 41% for bacmecillinam and 30% for pivmecillinam. The 400 mg dose of bacmecillinam gave a significantly higher plasma peak (p less than 0.001), AUC (p less than 0.001) and urinary recovery (p less than 0.001) than did pivmecillinam 400 mg. The plasma peaks appeared earlier and the rate of absorption was higher after bacmecillinam than after pivmecillinam (p less than 0.05). In conclusion, bacmecillinam had a better bioavailability than pivmecillinam in the tablet formulations studied. The AUC increased linearly with increasing doses of bacmecillinam. PMID:6293834

  20. Measuring the Impacts of a Volunteer-Based Community Development Program in Developing Volunteers' Leadership Skills

    Science.gov (United States)

    Meier, Amy; Singletary, Loretta; Hill, George

    2012-01-01

    This article summarizes the results of an evaluation of the impacts of a community development program to develop leadership skills in its adult volunteers. The evaluation featured 20 questions about leadership skills learned as a result of volunteer experiences. Data analysis strategies beyond a simple means ranking resulted in evidence…

  1. Neurobehavioral performance in volunteers after inhalation of white spirits with high and low aromatic content.

    Science.gov (United States)

    Juran, S A; Johanson, G; Ernstgård, L; Iregren, A; van Thriel, C

    2014-05-01

    The content of aromatic hydrocarbons in solvent mixtures, such as white spirits (WS), has been assumed a major contributor to the neurotoxic effects of these compounds. Hence, dearomatized WS have been introduced to the market rapidly in the last decade. Studies investigating other aromatic hydrocarbons (toluene) and animal models have supported the aforementioned assumption, but the current study is the first one to compare acute neurobehavioral effects of exposure to aromatic and dearomatized WS (aWS, daWS) content in human volunteers at current occupational exposure limit values. In a pseudo-randomized crossover design, six female and six male healthy volunteers were exposed to aWS and daWS at two concentrations (100 and 300 mg/m(3)) and to clean air for 4 h at rest. During each of the five exposure conditions, volunteers performed five neurobehavioral tasks that were selected following a multidisciplinary approach that accounted for findings from the cognitive neurosciences and mechanisms of solvent toxicity. Two of the tasks indicated performance changes during aromatic WS exposure, the working memory (WM) and the response shifting task, but both effects are difficult to interpret due to low mean accuracy in the WM task and due to a lack of dose-response relationship in the response shifting task. Healthy human volunteers showed weak and inconsistent neurobehavioral impairment after 4-h exposures to 100 and 300 mg/m(3) aromatic or dearomatized WS. Our multidisciplinary approach of selecting neurobehavioral test methods may guide the test selection strategies in future studies. PMID:24714767

  2. Synergy of Volunteer Measurements and Volunteer Computing for Effective Data Collecting, Processing, Simulating and Analyzing on a Worldwide Scale

    CERN Document Server

    Gordienko, Nikita; Fedak, Gilles; Gordienko, Yuri

    2015-01-01

    The paper concerns the hype idea of "Citizen Science" and the related paradigm shift: to go from the passive "volunteer computing" to other volunteer actions like "volunteer measurements" under guidance of scientists. They can be carried out by ordinary people with standard computing gadgets (smartphone, tablet, etc.) and the various standard sensors in them. Here the special attention is paid to the system of volunteer scientific measurements to study air showers caused by cosmic rays. The technical implementation is based on integration of data about registered night flashes (by radiometric software) in shielded camera chip, synchronized time and GPS-data in ordinary gadgets: to identify night "air showers" of elementary particles; to analyze the frequency and to map the distribution of "air showers" in the densely populated cities. The project currently includes the students of the National Technical University of Ukraine "KPI", which are compactly located in Kyiv city and contribute their volunteer measur...

  3. Management of Chinese restaurant

    OpenAIRE

    Cui , Longbo

    2009-01-01

    With Chinese economy developing rapidly, the Chinese restaurant is under the spotlight, but the management of Chinese restaurant is weak at the moment, especially on the service management, which is an important part of service management in the Chinese restaurant. On the other hand, the managers of Chinese restaurant should pay more attention on the service management for instance brand, service innovation. Service management is core and essential concept for every service company recently, ...

  4. Differences and similarities among volunteers who drop out during the first year and volunteers who continue after eight years.

    Science.gov (United States)

    Vecina Jiménez, María Luisa; Chacón Fuertes, Fernando; Sueiro Abad, Manuel J

    2010-05-01

    Differences and similarities between 130 volunteers who remain for more than eight years in the same non-profit organization and 110 volunteers who quit during the first year were analyzed in this paper. Both groups were chosen from a sample of 851 volunteers that were working as volunteers when we assessed the independent variables (Time 1). After a 12-month follow-up (Time 2), 209 (25%) of them had dropped out and 642 (75%) continued in the same organization. Using the previous time, we formed two groups made up of those who dropped out and had been in the organization less than a year and those who continued and had been in the organization more than 8 years. Results show that differences and similarities between both groups are coherent with the three-stage model of volunteer's duration (Chacón, Vecina, & Dávila, 2007). This model includes the functional approach of volunteers' motivations (Clary & Snyder, 1991), and the role identity approach (Callero, 1985), and indicates that people will remain as volunteers insofar as this satisfies the motivations that are relevant for them at the first stage, they develop organizational commitment at the second stage, and they develop role identity as volunteers at the third stage. More specifically, results show that it is possible to predict 85% of the cases correctly using seven variables. Volunteers who remain after eight years feel a higher level of emotional exhaustion, a higher level of organizational commitment, and a strong role identity as volunteers. They are also highly satisfied with the friendships in the organization and have a stronger intention to remain at the long-term (2 years). PMID:20480701

  5. Self-selection for personality variables among healthy volunteers.

    Science.gov (United States)

    Pieters, M S; Jennekens-Schinkel, A; Schoemaker, H C; Cohen, A F

    1992-01-01

    1. Healthy student volunteers (n = 103) participating in ongoing clinical pharmacological research completed the Dutch Personality Inventory (DPI), the Dutch version of the Spielberger State-Trait Anxiety Inventory (STAI-DY) and the Dutch version of the Sensation Seeking Scale (SSS). 2. The volunteers were more extrovert (P less than 0.001), more flexible (P less than 0.001), more tolerant or less impulsive (P less than 0.001), had more self-confidence and initiative (P less than 0.001), and were more satisfied and optimistic (P less than 0.01) when compared with the general norm. When compared with a student norm, volunteers had lower levels of state (P less than 0.001) and trait (P less than 0.05) anxiety. The general sensation seeking tendency of volunteers was higher than in the student norm group (P less than 0.001). The volunteers had a greater tendency to thrill-and-adventure-seeking (P less than 0.001) and to disinhibition (P less than 0.01). 3. Hence, volunteers were a selected sample of the total population of students. This may influence the interpretation of pharmacokinetic and pharmacodynamic parameters. 4. Personality screening should be added to the screening procedures for volunteers. PMID:1540478

  6. Genital sores - male

    Science.gov (United States)

    Sores - male genitals; Ulcers - male genitals ... A common cause of male genital sores are infections that are spread through sexual contact, such as: Genital herpes (small, painful blisters filled with clear ...

  7. Examination of P300 in Veteran Males: Aging, Physical Activity and Cognitive Processing

    OpenAIRE

    Kutlu, Necip; Buyukyazi, Gurbuz; Kaptan, Gulten; Selcuki, Deniz; Artug, Rengin

    2014-01-01

    Aim: In the recent years, the effects of long term exercise on physiological systems have been thoroughly investigated. The aim of this study was to investigate the effect of long-term physical exercise on cognitive processing in elderly male athletes. Materials and Methods: Master athletes who had been exercising regularly (EME), healthy sedentary elderly volunteers (HSE) and healthy sedentary middle-aged volunteers (HSMA) were included in the study. Indirect maximum oxygen uptake ca...

  8. Vitamin K status in healthy volunteers.

    Science.gov (United States)

    Theuwissen, E; Magdeleyns, E J; Braam, L A J L M; Teunissen, K J; Knapen, M H; Binnekamp, I A G; van Summeren, M J H; Vermeer, C

    2014-02-01

    Vitamin K's recommended dietary allowance (RDA) is based on the hepatic requirement for clotting factor synthesis, but substantial concentrations of undercarboxylated extra-hepatic Gla-proteins are found in the circulation of non-supplemented individuals. This suggests that vitamin K intake above the RDA is required for an optimal extra-hepatic vitamin K status. Circulating uncarboxylated osteocalcin (ucOC) and desphospho-uncarboxylated matrix Gla-protein (dp-ucMGP) are considered markers of the vitamin K status in bone and the vasculature, respectively. We measured these markers in 896 samples of healthy volunteers and defined target groups for vitamin K supplementation based on increased levels indicative of tissue-specific vitamin K deficiency. We studied the response to vitamin K supplements at different states of vitamin K deficiency by measuring the circulating dp-ucMGP level in samples from two short-term trials on menaquinone-7 (MK-7, vitamin K2) supplementation in 42 children and 68 adults. Children had high ucOC levels (3.4-96.9 ng ml(-1)); other age groups had values in the range of 1.5-5.0 ng ml(-1). From the age of 40 years, dp-ucMGP levels gradually increased. Children and adults with more pronounced vitamin K deficiency gave the highest responses to MK-7 supplementation. Children and adults above 40 years showed the largest tissue-specific vitamin deficiency and accordingly may benefit from MK-7 supplementation to improve their extra-hepatic vitamin K status. PMID:24296867

  9. Pharmacogenetics of healthy volunteers in Puerto Rico.

    Science.gov (United States)

    Claudio-Campos, Karla; Orengo-Mercado, Carmelo; Renta, Jessicca Y; Peguero, Muriel; García, Ricardo; Hernández, Gabriel; Corey, Susan; Cadilla, Carmen L; Duconge, Jorge

    2015-12-01

    Puerto Ricans are a unique Hispanic population with European, Native American (Taino), and higher West African ancestral contributions than other non-Caribbean Hispanics. In admixed populations, such as Puerto Ricans, genetic variants can be found at different frequencies when compared to parental populations and uniquely combined and distributed. Therefore, in this review, we aimed to collect data from studies conducted in healthy Puerto Ricans and to report the frequencies of genetic polymorphisms with major relevance in drug response. Filtering for healthy volunteers or individuals, we performed a search of pharmacogenetic studies in academic literature databases without limiting the period of the results. The search was limited to Puerto Ricans living in the island, excluding those studies performed in mainland (United States). We found that the genetic markers impacting pharmacological therapy in the areas of cardiovascular, oncology, and neurology are the most frequently investigated. Coincidently, the top causes of mortality in the island are cardiovascular diseases, cancer, diabetes, Alzheimer's disease, and stroke. In addition, polymorphisms in genes that encode for members of the CYP450 family (CYP2C9, CYP2C19, and CYP2D6) are also available due to their relevance in the metabolism of drugs. The complex genetic background of Puerto Ricans is responsible for the divergence in the reported allele frequencies when compared to parental populations (Africans, East Asians, and Europeans). The importance of reporting the findings of pharmacogenetic studies conducted in Puerto Ricans is to identify genetic variants with potential utility among this genetically complex population and eventually move forward the adoption of personalized medicine in the island. PMID:26501165

  10. Mercury concentration in hair samples from Chinese people in coastal cities

    Institute of Scientific and Technical Information of China (English)

    LIU Xiaojie; CHENG Jinping; Song Yuling; HONDA Shun'ichi; WANG Li; LIU Zheng; SAKAMOTO Mineshi; LIU Yuanyuan

    2008-01-01

    This investigation was made to estimate current normal concentrations of total mercury in the hair of Chinese coastal people. Hairsamples were collected from 659 healthy inhabitants in the areas along the coast and the rivers (such as Shanghai, Ningbo, Dalian,Xiamen, and Zhoushan) of China from Feb. 2005 to June 2006. Total mercury concentrations in the samples were analyzed by the coldvapor atomic adsorption spectrometry method (CVAAS). The results showed the geometric mean concentration of total mercury in thehair of the total population (N=659) was 0.83 μg/g, and the geometric mean of the concentrations of total mercury in the hair of themale (0.94 μg/g, 338 inhabitants with an average age of 35.2, age 2-93) was higher than that of the female (0.72 μg/g, 321 inhabitantswith an average age of 39.1, age 1-90). In both the male and female, the mean concentrations of total mercury in hair increased withage, and then gradually decreased. There was a significant correlation between the total hair mercury and the place of residence (p<0.01), and total hair mercury was the highest in volunteers who lived in Zhoushan. Over half of all sample concentrations were belowthe USEPA-recommended 1 μg/g. In Zhoushan (males, 2.44 μg/g; females, 1.94 [μg/g) and Ningbo (males, 1.06 μg/g; females, 1.02μg/g), it exceeded the recommended level. Very little females (0.3%) of reproductive age showed hair mercury levels close to 10 μg/g.It was thus concluded that fish consumption was a major current route for mercury exposure in China.

  11. Influence of Youth Volunteering on Socialization and Development of Competences

    Directory of Open Access Journals (Sweden)

    Valdas Pruskus

    2014-06-01

    Full Text Available Volunteering is one of manifestations of citizenship. It indicates the individual’s quality in terms of citizenship and the readiness to take an active part in public activities. The current paper analyses the phenomenon of volunteering (its place and role in ensuring public development and sustainability. The influence of volunteer - ing on the youth socialization and personal development of competences (in particular, social, professional and communicative is disclosed in the article. The article also highlights the motives and factors that promote and prevent the youth participation in voluntary activities.

  12. Improving remote sensing flood assessment using volunteered geographical data

    Directory of Open Access Journals (Sweden)

    E. Schnebele

    2013-03-01

    Full Text Available A new methodology for the generation of flood hazard maps is presented fusing remote sensing and volunteered geographical data. Water pixels are identified utilizing a machine learning classification of two Landsat remote sensing scenes, acquired before and during the flooding event as well as a digital elevation model paired with river gage data. A statistical model computes the probability of flooded areas as a function of the number of adjacent pixels classified as water. Volunteered data obtained through Google news, videos and photos are added to modify the contour regions. It is shown that even a small amount of volunteered ground data can dramatically improve results.

  13. Improving remote sensing flood assessment using volunteered geographical data

    Science.gov (United States)

    Schnebele, E.; Cervone, G.

    2013-03-01

    A new methodology for the generation of flood hazard maps is presented fusing remote sensing and volunteered geographical data. Water pixels are identified utilizing a machine learning classification of two Landsat remote sensing scenes, acquired before and during the flooding event as well as a digital elevation model paired with river gage data. A statistical model computes the probability of flooded areas as a function of the number of adjacent pixels classified as water. Volunteered data obtained through Google news, videos and photos are added to modify the contour regions. It is shown that even a small amount of volunteered ground data can dramatically improve results.

  14. THAI LITERATURES REFLECTING CHINESE IDENTITY IN THAI SOCIETY

    Directory of Open Access Journals (Sweden)

    Suchawadee Kesmanee

    2013-01-01

    Full Text Available Literatures present the picture of people’s lives in the society in details. There have been numerous studies on Chinese-Thai literatures but none of them has an in-depth study on the Chinese identity. This study has been conducted due to personal interest to analyze the authors’ effort to present the Chinese identity through the characters, contents and social contexts. The data were collected from Thai novels and documentaries dated between 1957 and 2007 of which main characters, content and context were related to the Chinese residing in Thailand. Data collected had been inspected, classified, analyzed and composed. It was found that the Thai literatures could possibly represent Chinese identity in Thai society in the areas of the relationship of the family members from being a male-dominated family to a female-accepted one, the conservation of Chinese language to represent the unity of the Chinese community, the importance of the Chinese opera and its struggle to survive in recent times and the existence of Chinese culture and tradition, which are acculturated and assimilated to the Thai culture. From the study of Chinese identity in Thai literature in four aspects: (1 family relationships, system of relatives and surnames; (2 Chinese Language; (3 Performing Arts and (4 Culture and tradition, it was found that no matter how strict the first generations are to the traditions, they cannot resist the cultural assimilation in the next generations, who are descendants of Chinese overseas in Thailand. Since these new generations were born and grew up in Thai culture, which is different from the one of their ancestors, their versions of Chinese traditions were affected by the Thai society, economy and political situations which led to the changes of the old Chinese tradition and even result in the loss of some tradition.

  15. Clinical meaning of myocardial washout in Tc-MIBI and Tc-PPN (tetrofosmin) myocardial SPECT in normal volunteers

    International Nuclear Information System (INIS)

    Background: There are few reports about the washout in Tc-MIBI and Tc-PPN rest myocardial SPECT. Purpose: To evaluate the differences of Tc-MIBI and Tc-PPN washout in gender and to compare the contraction fraction (CF) and washout, we obtained early and delayed images of Tc-multigated (MUGA) myocardial SPECT in normal volunteers and calculated ejection fraction (EF), CF and washout rate. Methods: Tc-MIBI and Tc-PPN MUGA myocardial SPECT was performed in normal volunteers (20-23 years old ,9 female and 10 male). Myocardial washout rate of Tc-MIBI and Tc-PPN was calculated from early and delayed images. EF was calculated from the early images by using QGS software. On the other hand, three-dimensional (3D) images were reconstructed from early images of Tc-MIBI and Tc-PPN using Application Visualization System Medical Viewer (AVS-MV), then threshold was set at 50%. The myocardial volume with a radioisotope count in end-diastole (ED:counts /ml) and end systole (ES:counts /ml) were calculated from the 3D image. Contraction fraction using AVS-MV(AVS-CF) was calculated by following formula. AVS-CF (ED-ES)/ED. Results: The MIBI washout rate was 22.0% in female, and 17.6% in male. The PPN washout rate was 29.5% in female, and 23.4% in male. The MIBI and PPN washout rates in female showed higher than male. QGS-EF and AVS-CF in female were higher than those in male {female and male: (QGS-EF of MIBI : 63.6% and 54.5%), (QGS-EF of PPN : 62.6% and 55.2%), (AVS-CF of MIBI : 48.3% and 36.2%), (AVS-CF of PPN : 48.0% and 39.2%)}.There was a good correlation between EF and AVS-CF of MIBI in all volunteers (r2=0.806, p<0.001). But there were no significant correlations between washout rate and EF of MIBI. There was a good correlation between washout rate and AVS-CF of PPN in all volunteers (r2=0.527, p<0.02). But there were no significant correlations between washout rate and PPN (r2=0.393, N.S.). Conclusion: Our results indicated that myocardial washout rates in female were higher

  16. Quantitative MRI comparison of pulmonary hemodynamics in mustard/senning-repaired patients suffering from transposition of the great arteries and healthy volunteers at rest

    International Nuclear Information System (INIS)

    In Mustard/Senning-repaired (MSR) patients, the right and left ventricles (RV, LV) act as the systemic and pulmonary ventricle, respectively. The purpose of the study was to compare non-invasively, at rest, pulmonary ventricle systolic function and hemodynamics in MSR patients with those of healthy volunteers. Velocity-encoded MR imaging was performed at the level of the main pulmonary artery (MPA) in ten male patients late after a Mustard/Senning correction performed early in infancy and in ten male volunteers. Both blood flow and MPA cross-sectional area variations were recorded over a complete cardiac cycle. MPA distensibility, body surface area (BSA)-normalized pulmonary ventricle systolic power and work were significantly lower in the MSR patients compared to volunteers. In particular, BSA-normalized LV systolic power and work in MSR patients were equal to 82 and 77% on average of those of the RV in volunteers (0.32 vs. 0.39 W/m2 and 0.10 vs. 0.13 J/m2), respectively. We conclude that in MSR patients at rest two unrelated findings were observed: (1) a reduced MPA distensibility and (2) a significantly lower systolic mechanical performance of the pulmonary LV compared to that of the RV in healthy volunteers. The latter quantification indirectly confirms the lowest systemic RV systolic mechanical performance previously published. (orig.)

  17. NRPB volunteer study: deposition and clearance of inhaled particles

    International Nuclear Information System (INIS)

    At the Board Meeting of the National Radiological Protection Board held on 15 February 1996, approval was given for an experimental study of the deposition and clearance of inhaled particles in the human nasal passage. This is the latest in a series of volunteer biokinetic studies that have been conducted at NRPB since its formation. This article explains the purpose of the study, how ethical approval was obtained, how the study will be performed, what volunteers will be asked to do, and what doses they will receive. Doses will of course be carefully controlled, and will be well below the annual limits set for such experiments. The success of the study is of course crucially dependent on recruitment of a sufficient number of volunteers. The aim of this article is to provide information to anyone who might be interested in volunteering. (UK)

  18. Willamette Valley - Invasive Species Management with Volunteers 2012

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Volunteers worked with refuge staff to survey for and treat invasive species on the Willamette Valley Refuges (Ankeny, Baskett Slough and WL Finley NWR). False...

  19. Willamette Valley - Invasive Species Management with Volunteers 2010

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Volunteers worked with staff to survey for and treat 17 different invasive species within the Willamette Valley Refuges (Ankeny, Baskett Slough and William L....

  20. Willamette Valley - Invasive Species Management with Volunteers 2011

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Volunteers worked with refuge staff to survey for and treat invasive species on the Willamette Valley Refuges (Ankeny, Baskett Slough and WL Finley NWR). Scotch...

  1. Willamette Valley - Invasive Species Management with Volunteers 2009

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Volunteers worked with staff to map and control invasive species within the Willamette Valley National Wildlife Refuge Complex refuges (William L. Finley, Ankeny,...

  2. 75 FR 65595 - Retired and Senior Volunteer Program Amendments

    Science.gov (United States)

    2010-10-26

    ... requirements. List of Subjects in 45 CFR Part 2553 Aged, Grant programs--social programs, Volunteers. For the... application by its responsiveness to published guidelines and to the overall purpose and objectives of...

  3. 76 FR 20243 - Retired and Senior Volunteer Program Amendments

    Science.gov (United States)

    2011-04-12

    ... 2553 Aged, Grant programs--social programs, Volunteers. For the reasons set forth in the preamble, the... Corporation reviews and determines the merits of an application by its responsiveness to published...

  4. Mid-Columbia - Invasive Species Management with Volunteers 2006

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Project will initiate a program for the early detection, monitoring and mapping of invasive species on McNary and Umatilla NWR's using Refuge volunteers. The...

  5. Gender sensitive research in a Chinese community

    DEFF Research Database (Denmark)

    Chan, Simon; Shaw, Ian Frank

    2016-01-01

    The aim of this article is to foster an awareness of the need for gender-sensitive research in the context of the methodological and ethical challenges posed by such research. We trace the development of gender sensitivity and masculinity in social work practice and research and connect this to an...... overview of the issues posed by research on sensitive topics. Reflecting on a research project involving Chinese male sexual abuse survivors, we draw conclusions illustrating and proposing a range of methodological practices and ethical safeguards. We underscore the importance of gender-sensitivity in...... performing research on sensitive topics with men in a Chinese community....

  6. MDMA Impairs Response to Water Intake in Healthy Volunteers

    OpenAIRE

    Baggott, Matthew J.; Garrison, Kathleen J.; Coyle, Jeremy R.; Galloway, Gantt P.; Barnes, Allan J.; Huestis, Marilyn A.; Mendelson, John E.

    2016-01-01

    Hyponatremia is a serious complication of 3,4-methylenedioxymethamphetamine (MDMA) use. We investigated potential mechanisms in two double-blind, placebo-controlled studies. In Study 1, healthy drug-experienced volunteers received MDMA or placebo alone and in combination with the alpha-1 adrenergic inverse agonist prazosin, used as a positive control to release antidiuretic hormone (ADH). In Study 2, volunteers received MDMA or placebo followed by standardized water intake. MDMA lowered serum...

  7. Volunteer-Based System for Research on the Internet Traffic

    DEFF Research Database (Denmark)

    Bujlow, Tomasz; Balachandran, Kartheepan; Hald, Sara Ligaard;

    2012-01-01

    To overcome the drawbacks of existing methods for traffic classification (by ports, Deep Packet Inspection, statistical classification) a new system was developed, in which the data are collected and classified directly by clients installed on machines belonging to volunteers. Our approach combines....... We released the system under The GNU General Public License v3.0 and published as a SourceForge project called Volunteer-Based System for Research on the Internet....

  8. Motivation of youth participation in the volunteer movement

    OpenAIRE

    Tamara Nezhina; Kseniya Petukhova; Natal'ya Chechetkina; Il'ziya Mindarova

    2014-01-01

    The purpose of this study was to determine existing practices of young volunteer recruitment, retention and motivation in Russian noncommercial and government organizations and compare them with the best practices in American organizations. To know this information is essential for government managers and NGO leaders to successfully attract and retain young people as volunteers in their organizations. The theories of economic man and altruistic man have shaped the methodology and research des...

  9. Bioavailability of two oral formulas of secnidazole in healthy volunteers

    OpenAIRE

    Patrícia Andréa Bertuol Montovani; Ana Maria Pugens Pinto; Mauricio Bedim dos Santos; Daiane Loss Vieira; Anelise Weich do Prado; Josélia Larger Manfio

    2009-01-01

    Secnidazole is an antimicrobial agent used primarily in the treatment of amoebiasis. For this bioequivalence study of secnidazole, twenty-eight healthy female volunteers were enrolled in a randomized crossover study. Each volunteer was given a single oral dose of secnidazole test preparation and then the reference preparation, or vice versa, with a wash out interval of two weeks. The plasma concentrations of secnidazole were determined by HPLC, and the samples were extracted with tert-butyl-m...

  10. Volunteered Geographic Information and Computational Geography: New Perspectives

    OpenAIRE

    Jiang, Bin

    2012-01-01

    Volunteered geographic information (VGI), one of the most important types of user-generated web content, has been emerging as a new phenomenon. VGI is contributed by numerous volunteers and supported by web 2.0 technologies. This chapter discusses how VGI provides new perspectives for computational geography, a transformed geography based on the use of data-intensive computing and simulations to uncover the underlying mechanisms behind geographic forms and processes. We provide several exempl...

  11. Improving remote sensing flood assessment using volunteered geographical data

    OpenAIRE

    Schnebele, E.; Cervone, G.

    2013-01-01

    A new methodology for the generation of flood hazard maps is presented fusing remote sensing and volunteered geographical data. Water pixels are identified utilizing a machine learning classification of two Landsat remote sensing scenes, acquired before and during the flooding event as well as a digital elevation model paired with river gage data. A statistical model computes the probability of flooded areas as a function of the number of adjacent pixels classified as water. Volunteered data ...

  12. Effects of Tocotrienol Supplementation on Hair Growth in Human Volunteers

    OpenAIRE

    Beoy, Lim Ai; Woei, Wong Jia; Hay, Yuen Kah

    2010-01-01

    Studies have shown an association between oxidative stress and alopecia. Patients with alopecia generally exhibit lower levels of antioxidants in their scalp area as well as a higher lipid peroxidation index. Tocotrienols belong to the vitamin E family and are known to be potent antioxidants. Hence, a study was conducted to investigate the effect of tocotrienol supplementation on hair growth in volunteers suffering from hair loss. Twenty one volunteers were randomly assigned to orally receive...

  13. Safety assessment of inhaled xylitol in mice and healthy volunteers

    OpenAIRE

    Kline Joel N; Businga Thomas R; Watt Janet L; Launspach Janice; Durairaj Lakshmi; Thorne Peter S; Zabner Joseph

    2004-01-01

    Abstract Background Xylitol is a 5-carbon sugar that can lower the airway surface salt concentration, thus enhancing innate immunity. We tested the safety and tolerability of aerosolized iso-osmotic xylitol in mice and human volunteers. Methods This was a prospective cohort study of C57Bl/6 mice in an animal laboratory and healthy human volunteers at the clinical research center of a university hospital. Mice underwent a baseline methacholine challenge, exposure to either aerosolized saline o...

  14. Increasing capacity & changing the culture : volunteer management in law enforcement

    OpenAIRE

    Cayson, Donna M.

    2009-01-01

    CHDS State/Local In the post-September 11 world, law enforcement agencies are struggling to protect their communities from the threat of global terrorism, and also preparing for and responding to natural and manmade disasters. The demands on municipal law enforcement agencies have never been greater. Today, more than ever, it is clear that volunteers can play a fundamental role in augmenting a department's homeland security efforts. Are there best practices when incorporating volunteers in...

  15. The role of Volunteered Geographic Information in participatory planning

    DEFF Research Database (Denmark)

    Knudsen, Anne-Marie Sanvig; Kahila, Maarit

    2012-01-01

    Due to developments in pervasive computing and the diffusion of digital media technologies, the amount of Volunteered Geographic Information (VGI) is rising rapidly. This paper investi- gates the potential of applying VGI to a participatory planning context. What kind of VGI was considered useful...... context, employing volunteered GPS tracking to capture everyday uses of the urban environment. The second case study was carried out in Finland, employing SoftGIS as a tool to identify and quantify place values....

  16. [Drug evaluation in healthy volunteers. Legislative and ethical aspects].

    Science.gov (United States)

    Warot, D

    1991-01-01

    Studies in healthy volunteers have been legalized since December 20th 1988 in France. The healthy volunteer is employed for a variety of studies in phases I and IV of drug development. This type of research can equally be called nontherapeutic in nature. Every experiment involving healthy volunteers should be approved by the Ethics Committee. Using volunteers within the department, company or other organisation, while offering advantages for the investigator should be prohibited as freedom of concept might not be safeguarded. As well, financial incentives may over-persuade individuals, including students, who have low incomes and promote the "professional volunteer". To avoid this problem, French law planned a national register. The potential benefits of such a disposition are still unknown. Having been given appropriate information concerning the drug trial, his obligations and rights, the healthy volunteer gives his written consent. Specific recommendations for nontherapeutic assessments of drug effects are given concerning prisoners, the mentally handicapped, women with a risk of frequency, children. Ethical considerations concerning research on a healthy population must go beyond the law recently promulgated in France. PMID:2050001

  17. Hospital administrative characteristics and volunteer resource management practices.

    Science.gov (United States)

    Intindola, Melissa; Rogers, Sean; Flinchbaugh, Carol; Della Pietra, Doug

    2016-05-16

    Purpose - The purpose of this paper is to explore the links between various characteristics of hospital administration and the utilization of classes of volunteer resource management (VRM) practices. Design/methodology/approach - This paper uses original data collected via surveys of volunteer directors in 122 hospitals in five Northeastern and Southern US states. Findings - Structural equation modeling results suggest that number of paid volunteer management staff, scope of responsibility of the primary volunteer administrator, and hospital size are positively associated with increased usage of certain VRM practices. Research limitations/implications - First, the authors begin the exploration of VRM antecedents, and encourage others to continue this line of inquiry; and second, the authors assess dimensionality of practices, allowing future researchers to consider whether specific dimensions have a differential impact on key individual and organizational outcomes. Practical implications - Based on the findings of a relationship between administrative characteristics and the on-the-ground execution of VRM practice, a baseline audit comparing current practices to those VRM practices presented here might be useful in determining what next steps may be taken to focus investments in VRM that can ultimately drive practice utilization. Originality/value - The exploration of the dimensionality of volunteer management adds a novel perspective to both the academic study, and practice, of volunteer management. To the authors' knowledge, this is the first empirical categorization of VRM practices. PMID:27119392

  18. Morphometric measurement of the patella on 3D model reconstructed from CT scan images for the southern Chinese population

    Institute of Scientific and Technical Information of China (English)

    Shang Peng; Zhang Linan; Hou Zengtao; Bai Xueling; Ye Xin; Xu Zhaobin; Huang Xu

    2014-01-01

    Background Due to racial differences in the morphology of the knee joint and due to most prostheses available in the market being designed using measurements from Caucasians,the objective of this study was to provide the morphometric data of the patella for the southern Chinese population for total knee arthroplasty (TKA),patellar resurfacing,and prostheses design.Methods The CT slices of the knee joint were obtained from both knees of 40 Chinese volunteers (20 females,20 males,and age from 20-25 years) by performing a computer tomographic scan.A 3D model was reconstructed by Mimics software based on the computed tomography images.Six metrical characteristics were measured by digital ruler.Statistical analysis was performed with the SPSS statistical program.Results The mean,standard deviation and P values of measurements and ratios were calculated using SPSS.All dimensions showed a significant gender difference with P<0.05,but the six variables of the left and right knees had no statistical significance with P>0.05.In addition,we studied the relationship between six couples (H-W,H-T,H-HAF,W-T,W-HAF,T-HAF) of the four variables (H:height,W:width,T:thickness and HAF:height of articulating facet) that were measured,which showed a significant correlation.Conclusions Examination of the southern Chinese population revealed that males have larger patellae than women.In both genders,comparing data between left and right knees shows no statistically significant difference.Compared with Westerners in previous studies,the patella in our study was thin and small.There was a good linear regression correlation between measurements of the patella.The indirect measurement method on 3D models makes it easy to obtain anatomical data,and the results can provide a region and gender specific database for morphometric measurements of the oatella,and can be helpful for designing implants suited for southern Chinese patients.

  19. The Frequency of Hepatitis B and C Among Volunteer Blood Donors in Balochistan

    Directory of Open Access Journals (Sweden)

    Zafar Ahmad Khan

    2007-08-01

    Full Text Available Background and Aims: In this cross-sectional study, the frequency of hepatitis B and C among volunteer blood donors in blood banks of Sandeman Provincial & Lady Duffren Hospitals, Quetta, Pakistan was estimated.Methods: 1474 blood donors were selected by convenient sampling. After obtaining informed consent, brief history and examination were done. They were tested for HBsAg and anti-HCV antibodies in laboratory. The collected data analyzed by SPSS 12.0 and results shown in frequencies and percentages.Results: Out of 1474 blood donors, 1284 (87.1% were males and 190 (12.9% were females. The mean age was 25 (range: 16-49 years. 71 (4.8% were positive for HBsAg (63 males & 8 females, 26 (1.8% for anti-HCV (21 males & 5 females and 4 (0.27% were positive for both (3 males & 1 female. Most of them belonged to ages 21-40 years.Conclusions: The frequency of hepatitis B is same as that of other part of the country contrary to the belief that Balochistan is a high prevalent region for hepatitis B as compare to the rest of the country, while the frequency of hepatitis C is less than expected. Health education and vaccination for hepatitis B should be encouraged and more vigilant efforts should be done.

  20. Tolerance and pharmacokinetics of single-dose intravenous hemoporfin in healthy volunteers

    Institute of Scientific and Technical Information of China (English)

    Pei-hong SUN; Xia ZHAO; Ying ZHOU; Yan LIANG; Hui-lin ZHANG; Yi-min CUI; Ji-ning TAO

    2011-01-01

    To investigate the safety,tolerability and pharmacokinetics of intravenous hemoporfin,a novel photosensitive drug for the treatment of port-wine stain (PWS),in healthy Chinese volunteers following single-dose administration.Methods:Thirty-six healthy Chinese subjects were enrolled.The subjects were administered hemoporfin (2.5,5,7.5 or 10 mg/kg) via single-dose intravenous infusion.Pharmacokinetics of the drug were studied in the groups with doses of 2.5,5 and 7.5 mg/kg,and tolerability was studied in all the 4 groups.Safety and tolerance were evaluated by monitoring adverse events and laboratory parameters,and pharmacokinetics were assessed by determining hemoporfin content with a validated high-performance liquid chromatography with fluorescence detection (HPLC/FLD) method.Results:Mild and transient adverse events occurred in the trial (n=1O),but none were serious,and no subjects were withdrawn from the trial.The gastrointestinal tract adverse events,such as nausea,stomach upset,abdominal pain and vomiting,were observed in the groups with doses of 7.5 and 10 mg/kg.Increased alanine aminotransferase (ALT) concentration was found in 3 subjects,and increased alkaline phosphatase (ALP) concentration in one subject.The half-life of hemoporfin for doses of 2.5,5,and 7.5 mg/kg was 1.26 h,1.31 h,and 1.70 h,respectively.Cmax and AUC increased with dose for intravenous single-dose administration of hemoporfin in the 2.5,5,and 7.5 mg/kg groups.Urinary excretion of hemoporfin within 12 h was less than 0.2%.Conclusion:Hemoporfin is safe and well-tolerated in healthy Chinese volunteers at a single intravenous dose of up to 10 mg/kg.It was rapidly cleared from the blood and had a short half-life,which insures a short light-avoidance period.

  1. Establishing a normal reference range for thromboelastography in North Indian healthy volunteers

    Directory of Open Access Journals (Sweden)

    Arulselvi Subramanian

    2014-01-01

    Full Text Available Background: Thromboelastography (TEG is relatively recent assay to analyze the coagulation state of a blood sample, providing a continuous visualization of physical changes occurring during blood coagulation. There is a paucity of published literature on assessment of coagulation status using TEG in Indian population. Aim: The primary aim of the following study is to establish normal reference values for TEG in North Indian healthy volunteers and secondary aim is to compare them with conventional plasma-based routine coagulation tests and the manufacturers reference range. Materials and Methods: A total of 200 healthy volunteers comprised of 100 males and 100 females of age groups between 20 and 50 years, were enrolled over a period of 1 year, i.e., 2011-2012. Thromboelastometry (TEM was performed on TEM-A automated thromboelastometer (Framar Biomedica, Rome, Italy, using whole blood non-additive (360 µl. TEG parameters analyzed were r-time, k-time, α-angle, maximal amplitude (MA. Prothrombin time (PT, activated partial thromboplastin time (aPTT and platelet count was performed for all volunteers. The 95% reference range was calculated as (mean-1.96 standard deviation [SD] to (mean + 1.96 SD. Results: Our reference values for 95% of 200 volunteers were r-time: 1.8-14.2 min, k-time: 0.7-7.3 min, α-angle: 27.3-72.3° and MA: 32.1-87.9 mm. Maximum clot strength was higher in women compared with men, however statistically insignificant. Overall 14.5% (29/200 of the volunteers had at least one abnormal parameter while 74% (149/200 had deranged TEG values using the manufacturer′s reference range. Statistically significant variation was seen in r-time for 84.8% (P < 0.001, for k-time, in 87.1% (P < 0.001, for α-angle in 83.7% (P < 0.001 and for MA in 84% (P < 0.001, between the manufacturer and our reference range. Conclusion: The efficacy of classical coagulation test has been well-established; on the contrary TEG is a fairly recent assay and

  2. Limited sampling strategy models for estimating the AUC of gliclazide in Chinese healthy volunteers.

    Science.gov (United States)

    Huang, Ji-Han; Wang, Kun; Huang, Xiao-Hui; He, Ying-Chun; Li, Lu-Jin; Sheng, Yu-Cheng; Yang, Juan; Zheng, Qing-Shan

    2013-06-01

    The aim of this work is to reduce the cost of required sampling for the estimation of the area under the gliclazide plasma concentration versus time curve within 60 h (AUC0-60t ). The limited sampling strategy (LSS) models were established and validated by the multiple regression model within 4 or fewer gliclazide concentration values. Absolute prediction error (APE), root of mean square error (RMSE) and visual prediction check were used as criterion. The results of Jack-Knife validation showed that 10 (25.0 %) of the 40 LSS based on the regression analysis were not within an APE of 15 % using one concentration-time point. 90.2, 91.5 and 92.4 % of the 40 LSS models were capable of prediction using 2, 3 and 4 points, respectively. Limited sampling strategies were developed and validated for estimating AUC0-60t of gliclazide. This study indicates that the implementation of an 80 mg dosage regimen enabled accurate predictions of AUC0-60t by the LSS model. This study shows that 12, 6, 4, 2 h after administration are the key sampling times. The combination of (12, 2 h), (12, 8, 2 h) or (12, 8, 4, 2 h) can be chosen as sampling hours for predicting AUC0-60t in practical application according to requirement. PMID:22638844

  3. Safety and pharmacokinetics of dicloxacillin in healthy Chinese volunteers following single and multiple oral doses

    OpenAIRE

    Wu GL; Zheng YL; Zhou HL; Hu XJ; Liu J; Zhai Y; Zhu MX; Wu LH; Shentu JZ

    2015-01-01

    Guolan Wu, Yunliang Zheng, Huili Zhou, Xingjiang Hu, Jian Liu, You Zhai, Meixiang Zhu, Lihua Wu, Jianzhong Shentu Research Center for Clinical Pharmacy, State Key Laboratory for Diagnosis and Treatment of Infectious Disease, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China Background: Dicloxacillin, a semisynthetic isoxazolyl penicillin antibiotic, has antimicrobial activity against a wide variety of gram-positive bacteria i...

  4. REPORT OF HLA DISTRIBUTION IN 2315 VOLUNTEER DONORS OF CHINESE BONE MARROW BANK FROM NORTHWEST CHINA

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    HumanLeukocyteAntigen(HLA)system, knownashumanmajorhistocompatibilitycomplex (MHC),playsakeyroleinantigenprocessing,im muneregulationandotheraspects.HLAisalsobeen calledastransplantingantigenasaccuratetypingof HLAonbothpatientanddonorcanincreasedramat icallythesuccessofallogeneicorgantransplantation, especiallybonemarrowtransplantation(BMT). HLAisahighlypolymorphismsystemanddistribu tionofantigensandallelevariesnotablyinpopula tionsaroundworld[1,2].SomeHLAantigensandal lelesareonlyfoundinspecialethnicg...

  5. How to Run Successful Teen Volunteer Programs - Forms for teen volunteers and teen advisory groups (TAG) -Powerpoint Presentations

    OpenAIRE

    Donald, Sarah; Donoghue, Vicki; Dawley, Amy

    2010-01-01

    Based on work with teen volunteers, teen advisory councils, teen reading buddy programs and anime and manga clubs, Sarah Donald, Vicki Donoghue and Amy Dawley discuss their successes with teenagers, and practical ways to serve teens in the community.

  6. Traditional Chinese Herb Combined with Surgery versus Surgery for Varicocele Infertility: A Systematic Review and Meta-Analysis

    OpenAIRE

    Rong-liang Dun; Min Yao; Long Yang; Xue-jun Cui; Jian-min Mao; Yu Peng; Guang-chong Qi

    2015-01-01

    Objective. The objective of this study was to conduct a systematic review to assess the effectiveness and safety of traditional Chinese herb combined with surgery for male varicocele infertility compared to surgery. Methods. Randomized controlled trials (RCTs) data of traditional Chinese herbs combined with surgery for male varicocele fertility versus surgery were collected by searching the Cochrane Library, Embase, PubMed, and Chinese databases. The risk of bias was assessed using Cochrane H...

  7. Oral taste recognition in health volunteers Reconhecimento oral do gosto em voluntários sadios

    Directory of Open Access Journals (Sweden)

    Milton Melciades Barbosa Costa

    2010-06-01

    Full Text Available CONTEXT: Taste food recognition has an important role in the nutritional conditions and also allows protection of the organism integrity against foods potentially dangerous. OBJECTIVE: To investigate the presence of the selective taste regions on the tongue and also the palate participation in the oral taste definition. METHODS: A standard tongue divided in six regions was exposed with the four basic tastes (sweet, salted, sour and bitter, 10 times each. Thirteen volunteers were studied from both side and 34 only from one side, performing 240 tests with opened mouth and 240 with closing mouth, just after tongue sapid stimulation. A second group, with 12 volunteers, had its taste recognition studied, with and without palate isolation, using silicone prosthesis (n = 120. RESULTS: From results, chi-square (3×2 and (2×2, nonparametric independency test with P = 0.05 were obtained. CONCLUSIONS: Anterior, medium and posterior regions of the tongue, at both sides, had the same taste discriminative capacity. Nevertheless, closed mouth increased immediate and late recognition capacity by palate participation. It was possible to admit that palate participation increase the sapid perception in the mouth, by recruitment of the palate taste receptors and also by fluid compression and its scattering over tongue surface.CONTEXTO: O reconhecimento dos gostos tem importante papel para as condições nutricionais e também para a proteção da integridade do organismo contra a ingestão de alimentos potencialmente perigosos. OBJETIVO: Investigar a presença na língua de regiões com capacidade seletiva para percepção dos gostos básicos e também verificar se e como o palato participa da definição dos gostos na cavidade oral. MÉTODOS: Uma língua padrão hipotética dividida em 6 regiões teve cada umas destas, exposta 10 vezes a cada um dos quatro sabores básicos (doce, salgado, azedo e amargo. Treze voluntários tiveram sua lingual estudada dos dois

  8. Digestive tract microbiota in healthy volunteers Microbiota no trato digestivo em voluntários saudáveis

    OpenAIRE

    Bruno Zilberstein; Alina G Quintanilha; Santos, Manoel A A; Denis Pajecki; Eduardo G Moura; Paulo Roberto Arruda Alves; Fauze Maluf Filho; João Ary Ubriaco de Souza; Joaquim Gama-Rodrigues

    2007-01-01

    PURPOSE: The aim of this study was to standardize the methods of sample collection of mucus from the digestive tract and to determine the microbiota in healthy volunteers from Brazil, collecting samples from the mouth, esophagus, stomach, duodenum, jejunum, ileum, colon, and rectum. METHODS: Microbiota of selected healthy volunteers from the oral cavity (n=10), the esophagus (n=10), the upper digestive tract (n=20), and the lower digestive tract (n=24) were evaluated through distinct collecti...

  9. Happy (Chinese) New Year!

    Science.gov (United States)

    Johnson, Georgia G.

    1979-01-01

    Suggestions are made for a classroom celebration of Chinese New Year, including discussion of the Chinese calendar and customs, a short list of appropriate children's stories, and food ideas, including a recipe for fortune cookies. (SJL)

  10. Volunteering in dementia care – a Norwegian phenomenological study

    Directory of Open Access Journals (Sweden)

    Söderhamn U

    2012-02-01

    Full Text Available Ulrika Söderhamn1, Bjørg Landmark2,3, Live Aasgaard2, Hilde Eide3, Olle Söderhamn11Center for Caring Research – Southern Norway, Faculty of Health and Sport Sciences, University of Agder, Grimstad, Norway; 2Institute of Research and Development for Nursing and Care Services, Municipality of Drammen, Drammen, Norway; 3Faculty of Health Sciences, Buskerud University College, Drammen, NorwayIntroduction: The number of people suffering from dementia will increase dramatically in the future, and this will be a great challenge and concern for health care services. It is assumed that volunteers will strengthen community health care services more in the future than they do today.Aim: The aim of this study was to elucidate lived experiences of working as a volunteer in an activity center with adapted activities for home-dwelling people with early stage dementia.Methods: Qualitative interviews were implemented in a group of nine female volunteers from an activity center in southern Norway. The interviews were recorded, transcribed verbatim, and analyzed with a descriptive phenomenological method. Results: Volunteering in an activity center for home-dwelling people with early stage dementia was reported to provide experiences of being useful and feeling satisfied with performing a good job. It was an advantage for the volunteers to have had experiences from life in general, but also as a health professional or as being the next of kin of a dementia sufferer. It was important for the volunteers to focus on the dementia sufferer and show caring behavior, and interaction with and the appreciation of the health care professionals were also important. The volunteers were motivated by being able to have influence and participate in the planning of the work, to be a part of the social setting, and to learn. However, for some volunteers it was difficult to adjust to an appropriate role.Conclusion: In order to promote volunteering in a caring context, mutual

  11. Measuring the volume of the hippocampus in healthy Chinese adults of the Han nationality on the high-resolution MRI

    International Nuclear Information System (INIS)

    Objective: To measure the volume of hippocampal formation (HPF) in healthy Chinese Han adults and provide database for researching on a variety of diseases associated with alteration of hippocampal structure. Methods: This is a clinical multi-center study. One thousand Chinese healthy volunteers (age range=18 to 70) recruited from 15 hospitals were divided into 5 groups, i. e., Group A (age range=18 to 30), B (age range=31 to 40), C (age range =41 to 50), D (age range =51 to 60), and E (age range = 61 to 70). Each group contained 100 males and 100 females. All of the volunteers were scanned by MR using T1 weighted three-dimensional magnetization prepared rapid acquisition gradient echo sequence. The margin of HPF were outlined manually for each side. Using multiple linear regression, relationships between hippocampal volume and sex, age, weight and height were analyzed respectively. Independent two sample t test was used to study the differences between male and female and between left and right. The differences of hippocampal volume among age groups were analyzed by ANOVA. Results: Hippocampal volume for left and right side were (4752±659) and (5032±660) mm3 respectively. The volume of HPF is significant correlated with gender and age, but without relevance to height and weight (left and right r=0.283,0.311, F=30.127,37.050,P3 respectively for men, and (4647±624) and (4904±630) mm3 for women. The right hippocampal volume was larger than the left (t=7.030,6.696, P3 respectively, while the volumes of the fight hippocampus were (5340± 647), (5276±582), (5264±620), (5133±661), (4894±699) mm3 respectively. Among age groups, the differences were statistically significant (left and right F=5.737,7.607, P0.05). There was no significant difference of hippocampal among different groups in women (P>0.05). Conclusions: With high-resolution MRI, the volume of the HPF was accurately measured, so as to provide the basic data for research of the hippocampus

  12. Chinese restaurant syndrome

    Directory of Open Access Journals (Sweden)

    Balachandran C

    1991-01-01

    Full Text Available A 24-year-old Chinese student with history of recurrent attacks of flushing with burning and dryness of face of 4 years duration showed exacerbation of the symptoms after oral provocation with 1 mg of Chinese salt. Patient was treated with 50 mg pyridoxine daily and restriction of the Chinese salt in diet with moderate improvement.

  13. Chinese varkens in Nederland

    OpenAIRE

    Zhang, W.L.; Huiskes, J.H.

    1992-01-01

    In China zijn in totaal 300 miljoen varkens van meer dan 100 rassen. Ze worden voor verschillende soorten productie gebruikt. Sommige Chinese rassen zijn in Frankrijk, Nederland en U.S.A. geomporteerd. De vraag is of Chinese varkens nuttig kunnen zijnvoor de varkensproductie in Nederland en zo ja welke Chinese varkens

  14. The influence of social activity on regional cerebral blood flow and mental function in the normal aged volunteers

    International Nuclear Information System (INIS)

    The infuence of social activity on regional cerebral blood flow (rCBF) and mental function was studied by Xe133 inhalation method in normal aged volunteers. Subjects: The first group consisted of 33 aged volunteers living in nursing home and exposed to little social stimuli. There were 15 males (mean age of 77 years) and 18 females (77 years). The second group consisted of 49 aged community volunteers who were confirmed socially active. There were 25 males (76 years) and 24 females (72 years). All subjects were healthy persons without a past hitory of cerebral diseases and lung diseases. There were no difference in blood pressure and hematocrit between the two groups. Method: The rCBF was measured by 16-ch-Novo-cerebrograph. Verbal intelligence was evaluated by the Hasegawa Simple Intelligence Scale for Aged. Performance intelligence was evaluated with the Kohs' Block Design Test. Results: 1) The mean rCBF in group I showed significantly lower value than that of group II, especially in the frontotemporal region. The performance intelligence was decreased in group I. However, there were no significant difference in the verbal intelligence between the two groups. 2) The aging effect on rCBF and intelligences was more prominent in group II. 3) In males, hemispheric rCBF of group I decreased bilaterally associated with the decrease of both intelligences. While the left hemispheric rCBF in females was relatively preserved as well as the preservation of verbal intelligence. These results indicate that the social environmental factors may have significant influence to aging of the brain especially in the males. (author)

  15. Aerobic fitness of elite female and male wrestlers

    OpenAIRE

    E Hübner-Woźniak; A Kosmol; Gajewski, J.

    2009-01-01

    Aim: The purpose of this study was to assess the aerobic fitness of elite female wrestlers, and to determine whether there are gender differences in the physiological response to graded exercise. Materials and Methods: Ten female and ten male freestyle wrestlers volunteered for the study. They all performed a graded exercise test on the treadmill until exhaustion. To measure lactate concentration capillary blood was taken from the finger tip at the end of every workload and after 3, 5 and 7 m...

  16. A single high dose of escitalopram disrupts sensory gating and habituation, but not sensorimotor gating in healthy volunteers

    DEFF Research Database (Denmark)

    Oranje, Bob; Wienberg, Malene; Glenthøj, Birte Yding

    2011-01-01

    Early mechanisms to limit the input of sensory information to higher brain areas are important for a healthy individual. In previous studies, we found that a low dose of 10mg escitalopram (SSRI) disrupts habituation, without affecting sensory and sensorimotor gating in healthy volunteers. In the...... current study a higher dose of 15mg was used. The hypothesis was that this higher dose of escitalopram would not only disrupt habituation, but also sensory and sensorimotor gating. Twenty healthy male volunteers received either placebo or 15mg escitalopram, after which they were tested in a P50...... suppression, and a habituation and prepulse inhibition (PPI) of the startle reflex paradigm. Escitalopram significantly decreased P50 suppression and habituation, but had no effect on PPI. The results indicate that habituation and sensory gating are disrupted by increased serotonergic activity, while...

  17. The effect of whisky and wine consumption on total phenol content and antioxidant capacity of plasma from healthy volunteers

    DEFF Research Database (Denmark)

    Duthie, GG; Pedersen, M W; PC, Morrice;

    1998-01-01

    OBJECTIVE: To assess whether consumption of 100 ml of whisky or red wine by healthy male subjects increasedplasma total phenol content and antioxidant capacity. DESIGN: A Latin square arrangement to eliminate ordering effectswhereby, after an overnight fast, nine volunteers consumed 100 ml of red...... wine, malt whisky or unmatured 'new make'spirit. Each volunteer participated on three occasions one week apart, consuming one of the beverages each time. Bloodsamples were obtained from the anticubital vein at intervals up to 4h after consumption of the beverages when a urinesample was also obtained....... RESULTS: Within 30 min of consumption of the wine and whisky, there was a similar andsignificant increase in plasma total phenol content and antioxidant capacity as determined by the ferric reducing capacityof plasma (FRAP). No changes were observed following consumption of 'new make' spirit. CONCLUSIONS...

  18. An Analysis of Valencia Community College's Policy Response to Local Community Agencies' Need for Student Volunteers.

    Science.gov (United States)

    Bennett, Lula M.

    A study was conducted at Valencia Community College (VCC) to evaluate VCC's success in meeting the community's need for volunteers, to determine the needs of student volunteers, and to discover what kinds of students were participating in the student volunteer program. Results of a questionnaire completed by 72 student volunteers indicated that…

  19. Manual on Volunteer Services in Homes for the Aging and Nursing Homes.

    Science.gov (United States)

    Brown, Philip S.

    Intended as a practical guide for the administrator in homes for the aging, this booklet provides direction on how to set up a volunteer program. Five steps in organizing a volunteer program are: (1) Launching a Volunteer Program, (2) Recruitment and Selection of Volunteers, (3) Orientation and Training Program (The Role and Function of a…

  20. Chinese Food in America

    OpenAIRE

    Jou, Diana T.

    2011-01-01

    How did Chinese food get to look like this? With more than 41,000 Chinese restaurants in America - 3 times the number of McDonald’s restaurants - Chinese food is one of the most accepted and misunderstood cuisines in the United States. From large cities to small towns, locals can always count on an order of orange chicken in a takeout box, with a few fortune cookies thrown in the bag. But what Americans view as Chinese food is far from a traditional Chinese meal, wh...

  1. Danish-accented Chinese

    DEFF Research Database (Denmark)

    Wang, Lei; Sloos, Marjoleine 莱娜; Zhang, Chun

    In search for a linguistic basis for the education of Chinese as a foreign language CFL in Denmark, we set up a new line of investigation into CFL. This research focuses on the phonetics and phonology of Mandarin Chinese as compared to Danish. Considering the sound systems of both languages, we...... note some differences and similarities. The most remarkable differences are: -Chinese has rhotic sounds (pinyin ch, zh, sh, r) but Danish does not -Chinese has affricates (c z ch zh tɕ j) but Danish does not What Danish shares with Chinese is the contrast between aspirated and plain consonants: pa...

  2. Evaluation of the Dermal Bioavailability of Aqueous Xylene in F344 Rats and Human Volunteers

    Energy Technology Data Exchange (ETDEWEB)

    Thrall, Karla D.(BATTELLE (PACIFIC NW LAB)); Woodstock, Angie D.(BATTELLE (PACIFIC NW LAB))

    2003-07-11

    Xylene is a clear, colorless liquid used as a solvent in the printing, rubber, and leather industries and is commonly found in paint thinners, paints, varnishes, and adhesives. Although humans are most likely to be exposed to xylene via inhalation, xylene is also found in well and surface water. Therefore, an assessment of the dermal contribution to total xylene uptake is useful for understanding human exposures. To evaluate the significance of these exposures, the dermal absorption of o-xylene was assessed in F344 male rats and human volunteers using a combination of real-time exhaled breath analysis and physiologically based pharmacokinetic (PBPK) modeling. Animals were exposed to o-xylene dermally. Immediately following the initiation of exposure, individual animals were placed in a glass off-gassing chamber and exhaled breath was monitored. Human volunteers participating in the study placed both legs into a stainless steel hydrotherapy tub containing an initial concentration of approximately 500 g/L o-xylene. Exhaled breath was continually analyzed from each volunteer before, during, and post-exposure to track absorption and subsequent elimination of the compound in real time. In both animal and human studies, a PBPK model was used to estimate the dermal permeability coefficient (Kp) to describe each set of exhaled breath data. Rat skin was found to be approximately 12 times more permeable to aqueous o-xylene than human skin. The estimated human and rat aqueous o-xylene Kp values were 0.005+/- 0.001 cm/hr and 0.058+/- 0.009 cm/hr, respectively.

  3. Male homosexuality: the adolescent's perspective.

    Science.gov (United States)

    Remafedi, G

    1987-03-01

    Although homosexual activity is prevalent among US teenagers, adolescent homosexuality per se has been a poorly understood phenomenon. The purpose of this investigation is to describe the meaning and experience of homosexuality from the adolescent's perspective. Twenty-nine male teenagers, self-described as gay (79%) or bisexual (21%), volunteered to participate in a structured interview, the purpose of which was to examine the definition of homosexuality, the acquisition of a gay identity, and the impact of sexuality on family, peers, and community. The youths demonstrated well-established sexual identities by the consistency of their sexual fantasies, interests, and behaviors over time. Homosexuality was more frequently described as a general attraction to men (48%) and an indicator of positive personal attributes (33%) than as an isolated sexual behavior. The subjects reported strong negative attitudes from parents (43%) and friends (41%) toward their sexualities. Discrimination (37%), verbal abuse from peers (55%), and physical assaults (30%) were frequently cited problems. These stressors may place the boys at high risk for physical and psychosocial dysfunction. PMID:3822631

  4. Occult HCV in Egyptian volunteer blood donors

    Directory of Open Access Journals (Sweden)

    Mostafa A. Amin 1, Kouka S. E. Abdel-Wahab 2 and Adel A.

    2013-01-01

    Full Text Available Objective: The study aims to investigate the risk of post-transfusion transmission of hepatitis c virus (HCV in the circumstances of occult HCV when anti-HCV is undetectable by ELISA and HCV-RNA is detected by RT-PCR in the plasma and or in peripheral blood mononuclear cells (PBMCs of donor blood and the recipients are immunocompromised. Patients & methods: The study covered 18 chronic renal failure patients (CRF [12 males (66.7% their age ranged from 28 to 65 years and 6 females (33.3 % their age ranged from 15 to 55 years] undergoing hemodialysis in Nile Hospital as part of their therapy have to receive blood transfusions (275 blood units for the first time. Commercial ELISA kits for anti-HCV and nested-RT-PCR (N-RT-PCR kits were used. Results: Anti-HCV was positive in one serum from the eighteen (5.5% poly transfused CRF patients at the end of the study while the seventeen sera were negative. This serum was also positive for HCV RNA by N-RT-PCR. Out of the 20 transfused blood units, one blood unit (three components were tested by blood banking anti-HCV negative by ELISA, were positive for HCV RNA by N-RT-PCR. The collective markers of this blood unit represent an occult HCV. The risk of acquiring post-transfusion HCV infection from an occult HCV blood unit is 5%. Real time PCR showed variation in the viral load of the serum of the infected CRF patient, the plasma of blood unit, the PBMCs of this blood unit whether activated by PHA-M or not.

  5. [Male urinary incontinence

    NARCIS (Netherlands)

    Boer, TA de; Heesakkers, J.P.F.A.

    2008-01-01

    *Urinary incontinence in males is gaining increasingly more attention. *Male urinary incontinence can be classified as storage incontinence due to overactive bladder syndrome or stress incontinence due to urethral sphincter dysfunction. *Most patients benefit from the currently available treatment o

  6. Causes of Male Infertility

    Medline Plus

    Full Text Available ... Cessation Links to Professional Societies and Organizations Home › Causes of Male Infertility Dr. Roger Lobo of the American Society for Reproductive Medicine covers causes of male infertility. "Understanding Infertility - The Basics" is ...

  7. Male pattern baldness (image)

    Science.gov (United States)

    Male pattern baldness is a sex-linked characteristic that is passed from mother to child. A man can more accurately predict his chances of developing male pattern baldness by observing his mother's father than ...

  8. Causes of Male Infertility

    Medline Plus

    Full Text Available ... to Professional Societies and Organizations Home › Causes of Male Infertility Dr. Roger Lobo of the American Society for Reproductive Medicine covers causes of male infertility. "Understanding Infertility - The Basics" is a series ...

  9. Causes of Male Infertility

    Science.gov (United States)

    ... to Professional Societies and Organizations Home › Causes of Male Infertility Dr. Roger Lobo of the American Society for Reproductive Medicine covers causes of male infertility. "Understanding Infertility - The Basics" is a series ...

  10. Objective and subjective assessment of digestion after ingestion of an iced dessert in healthy volunteers.

    Science.gov (United States)

    Garzaro, Massimiliano; Pecorari, G; Nadalin, J; Raimondo, L; Palmo, A; Baccega, M; Giordano, C

    2010-01-01

    The aim of our study is to assess, with objective measures, the impact on digestion of a coffee-flavoured iced dessert ingested at the end of a standardized meal; moreover, a subjective assessment, using a specific questionnaire, was carried out in order to compare objective and subjective data. Ten healthy male volunteers, after ENT and psychological assessment, underwent two scintigraphic evaluations (standardized meal without and with coffee-flavoured iced dessert) and, after the meal, filled in a specific questionnaire named dynamic digestibility questionnaire. In our sample the ingestion of the coffee-flavoured iced dessert seemed to improve the digestibility of a standardized meal: the difference between the curves of gastric emptying without and with iced dessert is statistically significant. These data are strongly confirmed by subjective assessment: the dynamic digestibility questionnaire (DDQ) showed a higher digestibility of a standardized meal with the coffee-flavoured iced dessert in comparison to a normal meal. The current study represents a preliminary report on this topic with a small sample of healthy volunteers: further studies on larger population are requested in order to confirm all the encouraging results herein discussed. PMID:20487635

  11. Ascending-dose study of noribogaine in healthy volunteers: pharmacokinetics, pharmacodynamics, safety, and tolerability.

    Science.gov (United States)

    Glue, Paul; Lockhart, Michelle; Lam, Fred; Hung, Noelyn; Hung, Cheung-Tak; Friedhoff, Lawrence

    2015-02-01

    Noribogaine is the active metabolite of the naturally occurring psychoactive substance ibogaine, and may help suppress withdrawal symptoms in opioid-dependent subjects. The objectives of this Phase I study were to assess the safety, tolerability, pharmacokinetic, and pharmacodynamic profiles of noribogaine. In this ascending single-dose, placebo-controlled, randomized, double-blind, parallel-group study in 36 healthy drug-free male volunteers, 4 cohorts (n = 9) received oral doses of 3, 10, 30, or 60 mg or matching placebo, with intensive safety and pharmacokinetic assessments out to 216 hours, along with pharmacodynamic assessments sensitive to the effects of mu-opioid agonists. Noribogaine was rapidly absorbed, with peak concentrations occurring 2-3 hours after oral dosing, and showed dose-linear increases of area under the concentration-time curve (AUC) and Cmax between 3 and 60 mg. The drug was slowly eliminated, with mean half-life estimates of 28-49 hours across dose groups. Apparent volume of distribution was high (mean 1417-3086 L across dose groups). No safety or tolerability issues were identified in any cohort. No mu-opioid agonist pharmacodynamic effects were noted in pupillometry or cold-pressor testing. Single oral doses of noribogaine 3-60 mg were safe and well tolerated in healthy volunteers. PMID:25279818

  12. Effects of Danshen Ethanol Extract on the Pharmacokinetics of Fexofenadine in Healthy Volunteers

    Directory of Open Access Journals (Sweden)

    Furong Qiu

    2014-01-01

    Full Text Available This study investigated the effect of multidose administration of danshen ethanol extract on fexofenadine pharmacokinetics in healthy volunteers. A sequential, open-label, two-period pharmacokinetic interaction design was used. 12 healthy male volunteers received a single oral dose of fexofenadine (60 mg followed by danshen ethanol extract (1 g orally, three times a day for 10 days, after which they received 1 g of the danshen extract with fexofenadine (60 mg on the last day. The plasma concentrations of fexofenadine was measured by LC-MS/MS. After 10 days of the danshen extract administration, the mean AUC and Cmax⁡ of the fexofenadine was decreased by 37.2% and 27.4% compared with the control, respectively. The mean clearance of fexofenadine was increased by 104.9%. The in vitro study showed that tanshinone IIA and cryptotanshinone could induce MDR1 mRNA. This study showed that multidose administration of danshen ethanol extract could increase oral clearance of fexofenadine. The increased oral clearance of fexofenadine is attributable to induction of intestinal P-glycoprotein.

  13. Examining Volunteer Motivations and Recruitment Strategies For Engagement in Urban Forestry

    OpenAIRE

    Christine Moskell; Shorna Broussard Allred; Gretchen Ferenz

    2010-01-01

    Few studies in urban forestry have examined the motivations of urban forestry volunteers. In this research, two social psychological theories (Volunteer Functions Inventory and Volunteer Process Model) are utilized to examine motivations for participating in tree planting activities. The Volunteer Functions Inventory can be used to examine the needs, goals and motivations that individuals seek to fulfill through volunteerism. The Volunteer Process Model sheds light on the antecedents, experie...

  14. ATLAS@Home: Harnessing Volunteer Computing for HEP

    CERN Document Server

    Bourdarios, Claire; Filipcic, Andrej; Lancon, Eric; Wu, Wenjing

    2015-01-01

    A recent common theme among HEP computing is exploitation of opportunistic resources in order to provide the maximum statistics possible for Monte-Carlo simulation. Volunteer computing has been used over the last few years in many other scientific fields and by CERN itself to run simulations of the LHC beams. The ATLAS@Home project was started to allow volunteers to run simulations of collisions in the ATLAS detector. So far many thousands of members of the public have signed up to contribute their spare CPU cycles for ATLAS, and there is potential for volunteer computing to provide a significant fraction of ATLAS computing resources. Here we describe the design of the project, the lessons learned so far and the future plans.

  15. Personality and Coping in Peruvian volunteers for poverty alleviation

    Directory of Open Access Journals (Sweden)

    Camila Gastelumendi Gonçalves

    2013-06-01

    Full Text Available This study explores the relationship between coping styles and strategies, and personality styles in a sample of 41 young volunteers of an institution that alleviates poverty in Lima. Peruvian adaptations of COPE and MIPS scales were administered. The results show that volunteers have higher scores on adaptive coping strategies. High scores in some particular personality styles were reported, which allowed to establish a personality profile of this group. According with theoretical framework, most coping strategies correlated with most personality styles, revealing four particular tendencies in these volunteers: they wish to have contact with other people, they usually see positive aspects of situations, they look forward for challenges, and they developed adaptive coping strategies.

  16. Correlation of nasal geometry with aerosol deposition in human volunteers

    International Nuclear Information System (INIS)

    The nasal airways act as the first filter in the respiratory tract to remove very large or small particles, that would otherwise penetrate to the lower airways. Aerosol deposition data obtained with human volunteers vary considerably under comparable experimental conditions. Reasons for the intersubject variations have been frequently attributed to the geometry of the nasal passages. Because there is no direct proof of this hypothesis, nasal deposition of ultrafine particles in human volunteers has been studied in our laboratory. Preliminary results obtained with four adult volunteers also vary considerably between subjects. The purpose of this part of the study was to establish a theoretical equation relating diffusional deposition in nasal airways to the geometrical dimensions of the individual nasal airways. This relationship was then applied to the experimental deposition data and measurement of airway morphometry for correlation

  17. Validation of G6PD Point-of-Care Tests among Healthy Volunteers in Yangon, Myanmar.

    Science.gov (United States)

    Oo, Nwe Nwe; Bancone, Germana; Maw, Lwin Zar; Chowwiwat, Nongnud; Bansil, Pooja; Domingo, Gonzalo J; Htun, Moh Moh; Thant, Kyaw Zin; Htut, Ye; Nosten, Francois

    2016-01-01

    Primaquine and other 8-amnoquinoline based anti-malarials can cause haemolysis in subjects with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Correct diagnosis of G6PD status in patients is crucial for safe treatment of both relapsing stages of Plasmodium vivax and transmitting forms of Plasmodium falciparum. Lack of suitable point-of-care tests has hampered a much needed wide use of primaquine for malaria elimination. In this study we have assessed the performances of two qualitative tests, the fluorescent spot test (FST) and the G6PD CareStart test (CST), against the gold standard quantitative spectrophotometric assay in a population of 1000 random adult healthy volunteers living in Yangon, Myanmar. The prevalence of G6PD deficiency in the Bamar, Karen and in the whole sample set was 6.6% (10.1% in males), 9.2% (21.0% in males) and 6.8% (11.1% in males) respectively. The FST and CST showed comparable performances with sensitivity over 95% and specificity over 90%, however for cases with severe G6PD activity the FTS had improved performance. If used with a conservative interpretation of the signal, the CareStart test has the potential to be used in the field and, by allowing a wider use of primaquine, to help malaria elimination. PMID:27035821

  18. Advantages of volunteer-based biodiversity monitoring in Europe.

    Science.gov (United States)

    Schmeller, Dirk S; Henry, Pierre-Yves; Julliard, Romain; Gruber, Bernd; Clobert, Jean; Dziock, Frank; Lengyel, Szabolcs; Nowicki, Piotr; Déri, Eszter; Budrys, Eduardas; Kull, Tiiu; Tali, Kadri; Bauch, Bianca; Settele, Josef; Van Swaay, Chris; Kobler, Andrej; Babij, Valerija; Papastergiadou, Eva; Henle, Klaus

    2009-04-01

    Without robust and unbiased systems for monitoring, changes in natural systems will remain enigmatic for policy makers, leaving them without a clear idea of the consequences of any environmental policies they might adopt. Generally, biodiversity-monitoring activities are not integrated or evaluated across any large geographic region. The EuMon project conducted the first large-scale evaluation of monitoring practices in Europe through an on-line questionnaire and is reporting on the results of this survey. In September 2007 the EuMon project had documented 395 monitoring schemes for species, which represents a total annual cost of about 4 million euro, involving more than 46,000 persons devoting over 148,000 person-days/year to biodiversity-monitoring activities. Here we focused on the analysis of variations of monitoring practices across a set of taxonomic groups (birds, amphibians and reptiles, mammals, butterflies, plants, and other insects) and across 5 European countries (France, Germany, Hungary, Lithuania, and Poland). Our results suggest that the overall sampling effort of a scheme is linked with the proportion of volunteers involved in that scheme. Because precision is a function of the number of monitored sites and the number of sites is maximized by volunteer involvement, our results do not support the common belief that volunteer-based schemes are too noisy to be informative. Just the opposite, we believe volunteer-based schemes provide relatively reliable data, with state-of-the-art survey designs or data-analysis methods, and consequently can yield unbiased results. Quality of data collected by volunteers is more likely determined by survey design, analytical methodology, and communication skills within the schemes rather than by volunteer involvement per se. PMID:19183201

  19. Psychometric properties of the Chinese Self-Directed Search (1994 edition)

    OpenAIRE

    Yang, W.; Lance, CE; Hui, HC

    2006-01-01

    In this study, we (a) examined the measurement equivalence/invariance (ME/I) of the Chinese Self-Directed Search (SDS; 1994 edition) across gender and geographic regions (Mainland China vs. Hong Kong); (b) assessed the construct validity of the Chinese SDS using Widaman's (1985, 1992) MTMM framework; and (c) determined whether vocational interests are measured equivalently by Chinese SDS subtests. Confirmatory factor analyses suggested that males and females from Mainland China and Hong Kong ...

  20. Validity of Bioelectrical Impedance Measurement in Predicting Fat-Free Mass of Chinese Children and Adolescents

    OpenAIRE

    Wang, Lin; Hui, Stanley Sai-chuen; Wong, Stephen Heung-sang

    2014-01-01

    Background The current study aimed to examine the validity of various published bioelectrical impedance analysis (BIA) equations in estimating FFM among Chinese children and adolescents and to develop BIA equations for the estimation of fat-free mass (FFM) appropriate for Chinese children and adolescents. Material/Methods A total of 255 healthy Chinese children and adolescents aged 9 to 19 years old (127 males and 128 females) from Tianjin, China, participated in the BIA measurement at 50 kHz...

  1. Self-selection for personality variables among healthy volunteers.

    OpenAIRE

    Pieters, M S; Jennekens-Schinkel, A; Schoemaker, H C; Cohen, A F

    1992-01-01

    1. Healthy student volunteers (n = 103) participating in ongoing clinical pharmacological research completed the Dutch Personality Inventory (DPI), the Dutch version of the Spielberger State-Trait Anxiety Inventory (STAI-DY) and the Dutch version of the Sensation Seeking Scale (SSS). 2. The volunteers were more extrovert (P less than 0.001), more flexible (P less than 0.001), more tolerant or less impulsive (P less than 0.001), had more self-confidence and initiative (P less than 0.001), and ...

  2. Physiologic effects of intravenous fluid administration in healthy volunteers

    DEFF Research Database (Denmark)

    Holte, Kathrine; Jensen, Peter; Kehlet, Henrik

    2003-01-01

    volunteers with a median age of 63 yr (range, 59-67 yr) received an infusion of lactated Ringer's solution 40 mL/kg (median, 2820 mL) or 5 mL/kg (median, 353 mL; background infusion) in random order on two separate occasions. The study was designed to mimic the perioperative course with preoperative fasting...... fluid administration. These findings may serve as a basis for clinical studies applying the same type of fluid in different amounts to determine the optimal amount of perioperative fluid in various surgical procedures. IMPLICATIONS: Infusion of 40 mL/kg of lactated Ringer's solution in volunteers led to...

  3. Galaxy Zoo: Exploring the Motivations of Citizen Science Volunteers

    CERN Document Server

    Raddick, M Jordan; Gay, Pamela L; Lintott, Chris J; Murray, Phil; Schawinski, Kevin; Szalay, Alexander S; Vandenberg, Jan

    2009-01-01

    The Galaxy Zoo citizen science website invites anyone with an Internet connection to participate in research by classifying galaxies from the Sloan Digital Sky Survey. As of April 2009, more than 200,000 volunteers had made more than 100 million galaxy classifications. In this paper, we present results of a pilot study into the motivations and demographics of Galaxy Zoo volunteers, and define a technique to determine motivations from free responses that can be used in larger multiple-choice surveys with similar populations. Our categories form the basis for a future survey, with the goal of determining the prevalence of each motivation.

  4. [Pharmacokinetics of cefixime in healthy volunteers after a single oral administration of 200 mg].

    Science.gov (United States)

    Montay, G; Le Liboux, A; Thebault, J J; Roche, G; Frydman, A; Gaillot, J

    1989-10-11

    The antibacterial activity of cefixime is identical with that of parenteral third generation cephalosporins. Its kinetics were studied in 24 healthy male volunteers who received one single 200 mg tablet. Cmax was 3.25 mg/l and Tmax was 4 h. After 12 hours, serum concentrations were still as high as 0.70 mg/l. Half-life was 3.3 h and urinary excretion was not predominant. Thus, cefixime was characterized by its relatively long serum half-life as compared with other cephalosporins. Despite some degree of individual variations, serum and urine concentrations of the antibiotic remained for 12 hours above the MIC of susceptible pathogens. PMID:2530537

  5. Dexamethasone prolongs local analgesia after subcutaneous infiltration of bupivacaine microcapsules in human volunteers

    DEFF Research Database (Denmark)

    Holte, Kathrine; Werner, Mads U; Lacouture, Peter G;

    2002-01-01

    BACKGROUND: The addition of small amounts of dexamethasone to extended-release formulations of bupivacaine in microcapsules has been found to prolong local analgesia in experimental studies, but no clinical data are available. METHODS: In a double-blinded study, 12 healthy male volunteers were...... randomized to receive simultaneous subcutaneous injections of bupivacaine microcapsules with dexamethasone and bupivacaine microcapsules without dexamethasone in each calf. Local analgesia was assessed with a validated human pain model; main parameters evaluated were thermal, mechanical, and pain detection...... curve [AUC]) were considered best estimate of analgesia. Safety evaluations were performed daily for the first weekand at 2 weeks, 6 weeks, and 6 months after injection. RESULTS: The addition of dexamethasone significantly prolonged local analgesia of bupivacaine microcapsules without influence on...

  6. Dexamethasone prolongs local analgesia after subcutaneous infiltration of bupivacaine microcapsules in human volunteers

    DEFF Research Database (Denmark)

    Holte, Kathrine; Werner, Mads U; Lacouture, Peter G;

    2002-01-01

    BACKGROUND: The addition of small amounts of dexamethasone to extended-release formulations of bupivacaine in microcapsules has been found to prolong local analgesia in experimental studies, but no clinical data are available. METHODS: In a double-blinded study, 12 healthy male volunteers were...... randomized to receive simultaneous subcutaneous injections of bupivacaine microcapsules with dexamethasone and bupivacaine microcapsules without dexamethasone in each calf. Local analgesia was assessed with a validated human pain model; main parameters evaluated were thermal, mechanical, and pain detection...... curve [AUC]) were considered best estimate of analgesia. Safety evaluations were performed daily for the first week and at 2 weeks, 6 weeks, and 6 months after injection. RESULTS: The addition of dexamethasone significantly prolonged local analgesia of bupivacaine microcapsules without influence on...

  7. Psychometric Properties of the Chinese Version of the Social Responsiveness Scale

    Science.gov (United States)

    Gau, Susan Shur-Fen; Liu, Li-Ting; Wu, Yu-Yu; Chiu, Yen-Nan; Tsai, Wen-Che

    2013-01-01

    This study evaluated the psychometric properties of the Chinese version of the Social Responsiveness Scale (Chinese SRS). We assessed 1419 grade 1 to grade 8 students from northern Taiwan and 401 clinic-based participants (aged 3-20, male 90.3%). All clinic-based participants were clinically diagnosed with autism spectrum disorders (ASDs),…

  8. Learned Helplessness: The Need for Self-Determinism among the Chinese American Elderly.

    Science.gov (United States)

    Wong, Eugene Franklin

    Chinese immigration to the United States in the 19th century was predominantly male. White racism led to the passage of Exclusion Laws, which severely restricted the immigration of the wives of the earlier migrants. This, coupled with miscegenation laws, has seriously affected the demographics of Chinese Americans. The underrepresentation of…

  9. Chinese Students and Scholars in the U.S.: An Intercultural Adaptation Process.

    Science.gov (United States)

    Zhong, Mei

    An ethnographic study examined the culture of the Chinese students and scholars in America with a specific focus on their experiences in the cultural adaptation process. Subjects were three Chinese nationals (one female and two males) living in the area of a large midwestern university. Subjects were interviewed for about an hour each, with…

  10. Dimensions of Difficulties Mainland Chinese Students Encounter in the United States.

    Science.gov (United States)

    Sun, Wei; Chen, Guo-Ming

    A study examined the difficulties Mainland Chinese students encountered in the process of adjusting to American culture. Subjects were 10 Mainland Chinese students enrolling in a mid-size public university, 8 females and 2 males. The length of time in America was from 10 months to 3 years, the average age was 27.9, and 6 were married. In-depth…

  11. Effect of age and gender on dopamine transporter imaging with [123I]FP-CIT SPET in healthy volunteers

    International Nuclear Information System (INIS)

    Dopamine transporter imaging is a valuable tool to investigate the integrity of the dopaminergic neurons. To date, several reports have shown an age-associated decline in dopamine transporters in healthy volunteers. Although animal studies suggest an effect of gender on dopamine transporter density, this gender effect has not yet been confirmed in human studies. To study the influence of age and gender on dopamine transporter imaging in healthy volunteers, we performed single-photon emission tomography imaging with [123I]FP-CIT to quantify dopamine transporters. Forty-five healthy volunteers (23 males and 22 females) were included, ranging in age from 18 to 83 years. SPET imaging was performed 3 h after injection of ±110 MBq [123I]FP-CIT. An operator-independent volume of interest analysis was used for quantification of [123I]FP-CIT binding in the striatum. The ratio of specific striatal to non-specific [123I]FP-CIT binding was found to decrease significantly with age. Moreover, we found a high variance in [123I]FP-CIT binding in young adults. Finally, females were found to have significantly higher [123I]FP-CIT binding ratios than males. This effect of gender on [123I]FP-CIT binding ratios was not related to age. The results of this study are consistent with findings from previous studies, which showed that dopamine transporter density declines with age. The intriguing finding of a higher dopamine transporter density in females than in males is in line with findings from animal studies. (orig.)

  12. Responding to the rape of Indonesian Chinese women and girls.

    Science.gov (United States)

    1998-09-01

    In May 1998, 168 women and girls were gang-raped during the Jakarta riots. In response, the Humanity Volunteer Team, a nongovernmental organization, set up a Violence Against Women Division. This group is composed of 400 people from diverse backgrounds and ethnic groups who undergo training and then volunteer their services to provide psychological and physical support to the affected victims and their families and to investigate the crimes. The volunteers have adopted a holistic approach and work with the cooperation of private hospitals. They accomplish their work in a climate of fear because it is considered subversive simply to bring this issue to light. Rape survivors and their families, as well as medical staff and volunteers, have been intimidated to the point that many rape survivors have traveled abroad to seek treatment. Long-term prevention strategies should include 1) a state apology to rape survivors and their communities, 2) an independent investigation to expose the perpetrators, and 3) the protection of the civil rights of the minority Chinese in Indonesia. PMID:12294313

  13. The impact of a short course of three lipid lowering drugs on fat oxidation during exercise in healthy volunteers.

    OpenAIRE

    Head, A; Jakeman, P. M.; Kendall, M. J.; Cramb, R.; Maxwell, S.

    1993-01-01

    We examined the impact of three lipid lowering drugs on fat oxidation during a 120 minute treadmill walk, at an exercise intensity of 50% maximal oxygen uptake (VO2 max). Subjects (N = 24) were healthy male volunteers with normal serum chemistry, assigned to three groups (n = 8). Group A received simvastatin 20 mg twice daily, Group B received gemfibrozil 600 mg twice daily, Group C received acipimox 600 mg twice daily. Each subject performed two 120 minute walks, once with drug, and once wit...

  14. Study on the relation between the degree of dental calcification and chronological age about Chinese Han nationality 6~18 years old male groups%中国汉族6~18周岁男性牙齿生长发育的年龄研究

    Institute of Scientific and Technical Information of China (English)

    田雪梅; 封华; 董迎春; 谭宇; 王晓明; 王昊; 韩冰; 庹琳; 王坚; 张继宗

    2011-01-01

    Objective This study was to explore the relation between degree of dental calcification and age on Chinese Han nationality adolescents and youths, then to set up equations for estimating age by digital orthopantomogram.Methods In accordance with the standard for grading the degree of dental calcification, the observer graded the degree of low mandibular dental calcification showing in digital orthopantomogram samples selected from 6 568 objects age range 6 ~18 years old,then dealt the figures with SPSS 13.0,in the end,established the regression equations for estimating age; besides, a blind test was done based on 160 pieces of digital orthopantomogram.Results There were no significant statistic differences in the low mandibular dental calcification degree between homonymic teeth, the nonparametric correlations between chronological age and dental calcification were above 0.7, the mean error between estimated age and chronological age was 0.423 ± 0.269 year.Conclusion The method set up in this study was reliable and would play an important role in estimating age for Chinese Han nationality adolescents and youths aged 6 ~ 18 years old in forensic science for male.%目的 研究牙齿钙化程度与年龄的关系,建立利用牙齿钙化程度推断中国汉族6~18周岁男性年龄的方程.方法 通过对6 568名6~18周岁汉族男性全口曲面断层影像上牙齿的钙化程度进行评分;将分级值及其对应年龄输入SPSS软件进行分析,建立推断年龄的方程模型;从研究样本外随机抽取已知年龄的样本160例进行盲测.结果 同名牙齿钙化评分值侧别间秩合检验结果P>0.05;下颌左侧恒牙钙化评分值与年龄相关分析结果r值均在0.7以上,下颌同名牙间相关系数r均在0.9以上;所建回归模型拟合优度R2=0.828,估计值标准误为1.23岁;盲测平均误差为0.423±0.269岁.结论 本研究所建立的方法准确可靠,可用于中国汉族6~18周岁男性人群的年龄推断.

  15. What Makes Them Pay? Values of Volunteer Tourists Working for Sea Turtle Conservation

    Science.gov (United States)

    Campbell, Lisa M.; Smith, Christy

    2006-07-01

    As charismatic mega-fauna, sea turtles attract many volunteers to conservation programs. This article examines the ways in which volunteers value sea turtles, in the specific context of volunteers working with the Caribbean Conservation Corporation, at Tortuguero, Costa Rica. The complexity of volunteer values is explored using a qualitative approach. In-depth interviews with 31 volunteers were conducted in July of 1999 and 2000. Interviews probed, among other things, interest in sea turtles and their conservation, motives for participating, and the most gratifying parts of their volunteer experience. Results show that volunteers hold multiple and complex values for sea turtles, but particular values dominate. Results have implications for understanding human-environment relations and the emerging study of volunteer tourism. There are also management implications for volunteer programs hoping to attract participants.

  16. Organizational Structures and Data Use in Volunteer Monitoring Organizations (VMOs)

    Science.gov (United States)

    Laird, Shelby Gull; Nelson, Stacy A. C.; Stubbs, Harriett S.; James, April L.; Menius, Erika

    2012-01-01

    Complex environmental problems call for unique solutions to monitoring efforts alongside developing a more environmentally literate citizenry. Community-based monitoring (CBM) through the use of volunteer monitoring organizations helps to provide a part of the solution, particularly when CBM groups work with research scientists or government…

  17. Disseminating Improved Practices: Are Volunteer Farmer Trainers Effective?

    Science.gov (United States)

    Lukuyu, B.; Place, F.; Franzel, S.; Kiptot, E.

    2012-01-01

    Purpose: This paper assesses the effectiveness of volunteer farmer trainers in promoting adoption of agricultural technologies in western Kenya. Specifically, the purpose was to assess the type of information they disseminated, farmer trainers' characteristics desirable to farmer trainees, and how trainees evaluate farmer trainers.…

  18. Systemic Pharmacokinetics of Rifaximin in Volunteers with Shigellosis▿

    OpenAIRE

    Taylor, David N.; McKenzie, Robin; Durbin, Anna; Carpenter, Colleen; Haake, Robert; Bourgeois, A. Louis

    2007-01-01

    Rifaximin is an oral antibiotic indicated for treatment of traveler's diarrhea. Rifaximin pharmacokinetics were evaluated in individuals challenged with Shigella flexneri. Peak plasma rifaximin concentrations were low after nine consecutive doses, and no accumulation was observed. Rifaximin serum levels were minimal and similar to those previously reported in studies of healthy volunteers.

  19. PILOT VOLUNTEER TRAINING FOR WETLAND MONITORING AND HEALTH ASSESSMENT

    Science.gov (United States)

    Massachusetts Bays Estuary Program expressed a need to better assess and monitor the health of their saltmarshes. By training citizen volunteers in the methodologies of saltmarsh bioassessment, Mass Bays saw the additional opportunity to engage the public in their estuary protec...

  20. Volunteer computers in homes to fight against Malaria in Africa

    CERN Multimedia

    2006-01-01

    "Africa@home, a project conceived and coordinated by CERN1, was launched publicly this week. It is recruiting volunteer computers in homes and offices to run a computer-intensive simulation program called MalariaControl.net, developed by researchers at the Swiss Tropical Institute (STI)" (1 page)

  1. Sense of Cohesion among Community Activists Engaging in Volunteer Activity

    Science.gov (United States)

    Levy, Drorit; Itzhaky, Haya; Zanbar, Lea; Schwartz, Chaya

    2012-01-01

    The present article attempts to shed light on the direct and indirect contribution of personal resources and community indices to Sense of Cohesion among activists engaging in community volunteer work. The sample comprised 481 activists. Based on social systems theory, three levels of variables were examined: (1) inputs, which included personal…

  2. Physiologic effects of intravenous fluid administration in healthy volunteers

    DEFF Research Database (Denmark)

    Holte, Kathrine; Jensen, Peter; Kehlet, Henrik

    2003-01-01

    fluid administration. These findings may serve as a basis for clinical studies applying the same type of fluid in different amounts to determine the optimal amount of perioperative fluid in various surgical procedures. IMPLICATIONS: Infusion of 40 mL/kg of lactated Ringer's solution in volunteers led to...

  3. Armenian Language Competencies for Peace Corps Volunteers in Armenia.

    Science.gov (United States)

    Vartanian, Vartan; Vartanian, Margaret

    The instructional materials for Armenian are designed for the language training of Peace Corps volunteers in Armenia. They use a competency-based approach focusing on content, cultural context, and communication purpose simultaneously. Some are closely tied to work tasks, others to daily communication needs. A brief introductory section gives an…

  4. A coordinated state/federal volunteer training program

    International Nuclear Information System (INIS)

    While the sinking of the Tenyo Maru and resultant oil spill off Washington's Olympic Peninsula in July 1991 was tragic, it fostered the birth of a cooperative effort by federal and state agencies to train volunteer responders prior to another oil spill. This effort, under the auspices of an Oregon nonprofit group known as SOLV (Stop Oregon Littering and Vandalism), is known as the SOS (SOLV Oil Spill) Steering committee. The purpose of the group is to train volunteer responders to aid federal, state, and local agencies in future oil spill cleanup activities. For the first time in the nation, governmental agencies have joined with corporations and environmental organizations in coordinating educational programs involving citizens in oil spill remediation efforts before the advent of a major spill that could affect coastal areas or inland waterways. Free classes meeting federal and state hazardous waste training criteria are offered quarterly to citizens interested in either volunteer wildlife rehabilitation or beach cleanup. The four-hour course was developed by the US Coast Guard, Oregon State Department of Environmental Quality, and Oregon OSHA. Topics covered include agency responsibilities, site safety plans, general safety, toxicology, material safety data sheets, personal protective equipment, decontamination, heat stress, helicopter safety, and wildlife safety. In addition to course materials, participants receive a certificate and identification card verifying their training. A 1-800 number, computer data base, and newsletter are used to maintain contact with graduates. So far more than 600 volunteers have been trained and are ready to assist should the need arise

  5. Informed consent in healthy volunteers: Whom does it protect?

    NARCIS (Netherlands)

    Van Vliet, A.A.; Wemer, J.; Wilffert, B.; De Vroedt, J.W.P.; Jonkman, J.H.G.

    1999-01-01

    In the next decade, centres for research on the safety, tolerability or bioequivalence of new molecular entities will be confronted with numerous compounds, a narrowing time frame for performing Phase I research activities, and a growing demand for healthy volunteers for participation in non-therape

  6. Galaxy Zoo: Exploring the Motivations of Citizen Science Volunteers

    Science.gov (United States)

    Raddick, M. Jordan; Bracey, Georgia; Gay, Pamela L.; Lintott, Chris J.; Murray, Phil; Schawinski, Kevin; Szalay, Alexander S.; Vandenberg, Jan

    2010-01-01

    The Galaxy Zoo citizen science website invites anyone with an Internet connection to participate in research by classifying galaxies from the Sloan Digital Sky Survey. As of April 2009, more than 200,000 volunteers have made more than 100 million galaxy classifications. In this article, we present results of a pilot study into the motivations and…

  7. Adults Who Learn Differently: Help through a Volunteer Literacy Program.

    Science.gov (United States)

    Skinner, Louise; Gillespie, Phyllis; Balkam, Lynda

    1997-01-01

    Presents an overview of preservice volunteer training at READ/San Diego, an adult literacy program. It discusses the program's informal assessment procedures that help identify possible language/learning disabilities and provide valuable information for instructional planning. Also described are selected multisensory teaching techniques designed…

  8. Systemic Pharmacokinetics of Rifaximin in Volunteers with Shigellosis▿

    Science.gov (United States)

    Taylor, David N.; McKenzie, Robin; Durbin, Anna; Carpenter, Colleen; Haake, Robert; Bourgeois, A. Louis

    2008-01-01

    Rifaximin is an oral antibiotic indicated for treatment of traveler's diarrhea. Rifaximin pharmacokinetics were evaluated in individuals challenged with Shigella flexneri. Peak plasma rifaximin concentrations were low after nine consecutive doses, and no accumulation was observed. Rifaximin serum levels were minimal and similar to those previously reported in studies of healthy volunteers. PMID:18086855

  9. Identifying Critical Thinking Styles to Enhance Volunteer Development

    Science.gov (United States)

    Gay, Keegan D.; Terry, Bryan; Lamm, Alexa J.

    2015-01-01

    Diversity in learning options can increase efficacy of volunteer development systems. The University of Florida Critical Thinking Inventory (UFCTI) is designed to explicate an individual's critical thinking style based upon a continuum from Seeking Information to Engagement. Static and interpretive materials are best used with individuals of a…

  10. CHINESE OF HUMANITY

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    A discussion of chinese curriculum of primary school under the background of new curriculum reform Mao xinjuan Feng haiying [Abstract] in recent years, Chinese learning received more and more attention by people article mainly from the national studies this course concepts, the curriculum reform of elementary school curriculum requirements and how to effective implementation of primary national studies course several aspects under the background of curriculum reform of Chinese primary curriculum the new school

  11. Safety assessment of inhaled xylitol in mice and healthy volunteers

    Directory of Open Access Journals (Sweden)

    Kline Joel N

    2004-09-01

    Full Text Available Abstract Background Xylitol is a 5-carbon sugar that can lower the airway surface salt concentration, thus enhancing innate immunity. We tested the safety and tolerability of aerosolized iso-osmotic xylitol in mice and human volunteers. Methods This was a prospective cohort study of C57Bl/6 mice in an animal laboratory and healthy human volunteers at the clinical research center of a university hospital. Mice underwent a baseline methacholine challenge, exposure to either aerosolized saline or xylitol (5% solution for 150 minutes and then a follow-up methacholine challenge. The saline and xylitol exposures were repeated after eosinophilic airway inflammation was induced by sensitization and inhalational challenge to ovalbumin. Normal human volunteers underwent exposures to aerosolized saline (10 ml and xylitol, with spirometry performed at baseline and after inhalation of 1, 5, and 10 ml. Serum osmolarity and electrolytes were measured at baseline and after the last exposure. A respiratory symptom questionnaire was administered at baseline, after the last exposure, and five days after exposure. In another group of normal volunteers, bronchoalveolar lavage (BAL was done 20 minutes and 3 hours after aerosolized xylitol exposure for levels of inflammatory markers. Results In naïve mice, methacholine responsiveness was unchanged after exposures to xylitol compared to inhaled saline (p = 0.49. There was no significant increase in Penh in antigen-challenged mice after xylitol exposure (p = 0.38. There was no change in airway cellular response after xylitol exposure in naïve and antigen-challenged mice. In normal volunteers, there was no change in FEV1 after xylitol exposures compared with baseline as well as normal saline exposure (p = 0.19. Safety laboratory values were also unchanged. The only adverse effect reported was stuffy nose by half of the subjects during the 10 ml xylitol exposure, which promptly resolved after exposure completion. BAL

  12. Effects of exercise rehab on male asthmatic patients: Aerobic verses rebound training

    OpenAIRE

    Vahid Zolaktaf; Ghasemi, Gholam A; Morteza Sadeghi

    2013-01-01

    Background: There are some auspicious records on applying aerobic exercise for asthmatic patients. Recently, it is suggested that rebound exercise might even increase the gains. This study was designed to compare the effects of rebound therapy to aerobic training in male asthmatic patients. Methods: Sample included 37 male asthmatic patients (20-40 years) from the same respiratory clinic. After signing the informed consent, subjects volunteered to take part in control, rebound, or aerobic ...

  13. PRE-EXERCISE ARGININE SUPPLEMENTATION INCREASES TIME TO EXHAUSTION IN ELITE MALE WRESTLERS

    OpenAIRE

    2014-01-01

    Dietary supplements containing arginine are among the most popular ergogenics intended to enhance strength, power and muscle recovery associated with both anaerobic and aerobic exercise. The aim of the present study was to evaluate the possible effect of pre-exercise acute intake of arginine on performance and exercise metabolism during incremental exhaustive exercise in elite male wrestlers. Nine volunteer elite male wrestlers (24.7±3.8 years) participated in this study. The test-retest prot...

  14. Effects of Exercise Rehab on Male Asthmatic Patients: Aerobic Verses Rebound Training

    OpenAIRE

    Zolaktaf, Vahid; Ghasemi, Gholam A; Sadeghi, Morteza

    2013-01-01

    Background: There are some auspicious records on applying aerobic exercise for asthmatic patients. Recently, it is suggested that rebound exercise might even increase the gains. This study was designed to compare the effects of rebound therapy to aerobic training in male asthmatic patients. Methods: Sample included 37 male asthmatic patients (20-40 years) from the same respiratory clinic. After signing the informed consent, subjects volunteered to take part in control, rebound, or aerobic gro...

  15. Aging male syndrome

    Directory of Open Access Journals (Sweden)

    Valer Donca

    2012-12-01

    Full Text Available Aging Male Syndrome is a medical condition through which men could pass between the ages of 35 and 65, when testosterone levelsin their body decline considerably. Androgen deficiency in the aging male has become a topic of increasing interest and debate throughout theworld. In contrast to female menopause, the process of aging in the male genital system is slow and highly variable between individuals. Thecharacteristic symptoms of Aging Male Syndrome include weakness, depression, fatigue and changes in body hair and skin, decreased sexualdesire, decreased lean body mass accompanied by increased visceral fat, decreased bone mineral density. Aging Male Syndrome is usually diagnosedby testing the blood for testosterone levels. The usual treatment method for Aging Male Syndrome includes testosterone injections,testosterone patches, testosterone gels and oral preparations.

  16. Assessment of cardiac morphology and ventricular function in healthy Chinese individuals using MRI

    International Nuclear Information System (INIS)

    Objective: To investigate reproducibility of cardiac MRI for assessment of cardiac morphology and ventricular function in selected normal Chinese Han population. Methods: Two hundred and sixty-nine normal volunteers underwent cardiac MRI using a 1.5 T MR system. HASTE and steady state free precession imaging were performed with long and short axis images and cine mode through the ventricle with wireless vector cardiac gating. The images were reviewed by two independent observers. The dimensions of cardiac chambers and ventricular function including ejection fraction (EF), end diastolic volume (EDV) , end systolic volume (ESV) and myocardial mass were evaluated. The data between male and female were compared by using two-tailed unpaired t test. Results: Total imaging time was (15±3) min. The anteroposterior diameter of the left atrium was (2.87±0.77) cm, the right atrial diameter perpendicular to the atrial septum was (3.61±0.57) cm, the end diastolic diameter of the left ventricle was (4.97± 0.52) cm, the end diastolic diameter of the right ventricle was (2.65±0.48) cm. On the left ventricle, EF was (60.62±7.08)%, EDV was (115.37±26.71) ml, ESV was (46.02±15.72) ml and LV mass was (82.97±24.03) g. On the right ventricle, EF was (47.73±6.50)%, EDV was (128.27±32.16) ml, ESV was (67.7±21.07) ml and RV mass was (48.24±13.42) g. There were no statistically significant differences in LVESV (P=0.144), LVEDV index (P=0.714), LVESV index (P=0.113), LVCI (P=0.199), RVEF (P=0.296) and RV mass (P=0.093), and statistically significant differences in other cardiac parameters between male and female. Conclusion: Cardiac MRI can provide useful information about cardiac function and morphology with a high level of reproducibility in normal Chinese Han population. (authors)

  17. Male mate choice in hermit crabs: prudence by inferior males and simple preference by superior males

    OpenAIRE

    Wada, Satoshi; Arashiro, Yuusei; Takeshita, Fumio; Shibata, Yasutoki

    2011-01-01

    In species with both male-male competition and male mate choice, inferior males may make different mate choice decisions from superior males. Males of the intertidal hermit crab, Pagurus middendorffii, are known to conduct precopulatory guarding and to adjust the threshold for guarding according to social parameters, such as encounter rate with females, competitor size, and sex ratio. Larger males are stronger in male--male competition during guarding in this species. We here tested whether m...

  18. Imaging male breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    Doyle, S., E-mail: sdoyle2@nhs.net [Primrose Breast Care Unit, Derriford Hospital, Plymouth (United Kingdom); Steel, J.; Porter, G. [Primrose Breast Care Unit, Derriford Hospital, Plymouth (United Kingdom)

    2011-11-15

    Male breast cancer is rare, with some pathological and radiological differences from female breast cancer. There is less familiarity with the imaging appearances of male breast cancer, due to its rarity and the more variable use of preoperative imaging. This review will illustrate the commonest imaging appearances of male breast cancer, with emphasis on differences from female breast cancer and potential pitfalls in diagnosis, based on a 10 year experience in our institution.

  19. Hypokalaemia and other non-bronchial effects of inhaled fenoterol and salbutamol: a placebo-controlled dose-response study in healthy volunteers.

    OpenAIRE

    Scheinin, M; Koulu, M.; Laurikainen, E.; Allonen, H

    1987-01-01

    1. The hypokalaemia-inducing effects of two widely used inhaled antiasthmatic beta 2-adrenoceptor agonists, fenoterol and salbutamol, were compared in six healthy male volunteers. 2. Each drug was administered in three different doses, 400, 600 and 800 micrograms, which were repeated three times with 30 min intervals (total doses 1200, 1800 and 2400 micrograms in 1 h). The treatments were given at 1 week intervals in random order in a single-blind fashion. 3. The concentration of potassium in...

  20. Dream Interpretation Sessions: Who Volunteers, Who Benefits, and What Volunteer Clients View as Most and Least Helpful.

    Science.gov (United States)

    Hill, Clara E.; And Others

    1997-01-01

    Analysis of college students participating in a dream interpretation session found that compared to nonvolunteers, students who volunteered had more positive attitudes towards dreams, recalled dreams more frequently, were more open, were higher in absorption, and were more often female. Helpful aspects of dream interpretations included insights…

  1. 46,XX Male Syndrome

    Directory of Open Access Journals (Sweden)

    Bekir Uçan

    2013-06-01

    Full Text Available 46, XX male syndrome – testicular disorder of sexual differentiation (DSD is a rare condition characterized by a spectrum of clinical presentations, ranging from ambiguous to normal male genitalia. These cases are diagnosed more easily in childhood. In adults, the diagnosis can be difficult due to the current normal gender development. Here, we report hormonal, molecular and cytogenetic results in an adult male patient with primary hypogonadism who was diagnosed with 46, XX male syndrome in our clinic. Turk Jem 2013; 17: 46-8

  2. THE EFFECT OF THE MULTIGLYCOSIDES OF TRIPTERYGIUM WILFORDII ON THE HYPOTHALAMOPITUITARY-TESTIS AXIS OF MALE RATS

    Institute of Scientific and Technical Information of China (English)

    TONGJian-Sun; QINJin-Xi; LIUXi-Guang; SUNYun-Tian; D.M.deKretser

    1989-01-01

    The multiglycosides of Tripterygium wilfordii Hook. f. (GTW) is a Chinese herb medicine used traditionally for the treatment of rheumatoid arthritis, chronic nephritis and some skin diseases. It has been recently shown to cause infertility in men, male rats and

  3. "Do-It-Ourselves Science": Case Studies of Volunteer-Initiated Citizen Science Involvement

    Science.gov (United States)

    Raddick, Jordan; Bracey, G.; Gay, P. L.

    2009-05-01

    Galaxy Zoo is a citizen science website in which members of the public volunteer to classify galaxies, thereby helping astronomers conduct publishable research into galaxy morphologies and environments. Although the site was originally created to answer a few specific questions, some members of the community - both scientists and volunteers - have spontaneously developed an interest in a wider variety of questions. Volunteers have pursued answers to these questions with guidance from professional astronomers; in completing these projects, volunteers have independently used some of the same data viewing and analysis tools that professional astronomers use, and have even developed their own online tools. They have created their own research questions and their own plans for data analysis, and are planning to write scientific papers with the results to be submitted to peer-reviewed scientific journals. Volunteers have identified a number of such projects. These volunteer-initiated projects have extended the scientific reach of Galaxy Zoo, while also giving volunteers first-hand experience with the process of science. We are interested in the process by which volunteers become interested in volunteer-initiated projects, and what tasks they participate in, both initially and as their involvement increases. What motivates a volunteer to become involved in a volunteer-initiated project? How does his or her motivation change with further involvement? We are conducting a program of qualitative education research into these questions, using as data sources the posts that volunteers have made to the Galaxy Zoo forum and transcripts of interviews with volunteers.

  4. Accentedness and intelligibility of Mandarin-accented English for Chinese, Koreans and Americans

    DEFF Research Database (Denmark)

    Hardman, Jocelyn

    2014-01-01

    accuracy and listener L1 and word familiarity. Participants included 6 male graduate students (Chinese & American) as talkers and 64 male and female graduate students (Chinese, Korean, & American) as listeners. In a counter balanced word-recognition-in-noise experiment, listeners were presented with 60......, American listeners still performed better. Analyses of mistranscribed Mandarin-accented English words revealed different areas of difficulty by listener L1. While front vowels and diphthongs were problematic for all listeners, Chinese listeners found different consonants in different word positions to be...

  5. A Morphological and Histological Characterization of Male Flower in Chestnut (Castanea) Cultivar ‘Yanshanzaofeng’

    OpenAIRE

    Feng Zou; Su-Juan Guo; Huan Xiong; Peng Xie; Wen-Jun Lv; Guang-Hui Li

    2013-01-01

    Chinese chestnut (Castanea mollissima Blume.) is a widely distributed fruit tree and well known for its ecological and economic value. In order to evaluate obstacles to male reproductive in the C. mollissima, a morphological and histological characterization of male flower of chestnut cultivar ‘Yanshanzaofeng’ were examined by paraffin section technique and scanning electron microscopy. The results showed that male catkins with floral primordia were formed in the buds of one-year olds shoots ...

  6. Effects of mating status on copulation investment by male bushcricket Gampsocleis gratiosa (Tettigoniidae, Orthoptera)

    Institute of Scientific and Technical Information of China (English)

    GAO Yong; KANG Le

    2006-01-01

    Male's copulation investment, including spermatophore and sperm investment were very high in the Chinese bushcricket Gampsocleis gratiosa. The effects of mating status of both males and females on male's copulation investment were examined in this study. The fresh weight of spermatophylax increased positively with the weight of males' body. This indicated that the nutritional investment during copulation depended on male's quality. Spermatophore investment showed insignificant differences in every copulation protocols. This finding supported the paternal investment hypothesis, that is, males contributed to their offspring with little attention to their partners. Sperm releasing per ejaculation varied significantly among the trials. Males decreased 54.19% sperm in second mating than in its first mating, demonsrated that males regarded the first mating highly, and were more prudent in subsequent mating. These males' strategies may contribute to the viability of the offspring.

  7. Relative Bioavailability of Rifampicin in Four Chinese Fixed-dose Combinations Compared with Rifampicin in Free Combinations

    Institute of Scientific and Technical Information of China (English)

    Hui Zhu; Shao-Chen Guo; Lan-Hu Hao; Cheng-Cheng Liu; Bin Wang; Lei Fu; Ming-Ting Chen

    2015-01-01

    Background:Decreases in the bioavailability of rifampicin (RFP) can lead to the development of drug resistance and treatment failure.Therefore,we investigated the relative bioavailability of RFP from one four-drug fixed-dose combination (FDC; formulation A) and three two-drug FDCs (formulations B,C,and D) used in China,compared with RFP in free combinations of these drugs (reference),in healthy volunteers.Methods:Eighteen and twenty healthy Chinese male volunteers participated in two open-label,randomized two-period crossover (formulations A and C) or one three-period crossover (formulations B and D) study,respectively.The washout period between treatments was 7 days.Bioequivalence was assessed based on 90% confidence intervals,according to two one-sided t-tests.All analyses were done with DAS 3.1.5 (Mathematical Pharmacology Professional Committee of China,Shanghai,China).Results:Mean pharmacokinetic parameter values of RFP obtained for formulations A,B,C,and D products were 11.42 ± 3.41 μg/ml,7.86 ± 5.78 μg/ml,13.05 ± 6.80 μg/ml,and 16.18 ± 3.87 μg/ml,respectively,for peak plasma concentration (Cmax),91.43± 30.82 μg·h-1 ·ml-1,55.49 ± 37.58 μg·h-1·ml-1,96.50 ± 47.24 μg·h-1·ml-1,101.47 ± 33.07 μg·h-1·ml-1,respectively,for area under the concentration-time curve (AUC0-2,4 h).Conclusions:Although the concentrations of RFP for formulations A,C,and D were within the reported acceptable therapeutic range,only formulation A was bioequivalent to the reference product.The three two-drug FDCs (formulations B,C and D) displayed inferior RFP bioavailability compared with the reference (Chinese Clinical Trials registration number:ChiCTR-TTRCC-12002451).

  8. Chinese Foods; Teacher's Handbook.

    Science.gov (United States)

    Huang, Joe, Ed.

    Different styles of Chinese cooking, traditional food items, cooking utensils, serving techniques, and the nutritional value of Chinese cooking are described in this teaching guide. Lesson plans for the preparation of simple dishes are presented. Recipes, a shopping guide to San Francisco's Chinatown, a guide to sources of supplies, and a…

  9. Confucius Teaching Chinese Abroad

    Institute of Scientific and Technical Information of China (English)

    TANG YUANKAI

    2010-01-01

    @@ On December 1, 2009, the Confucius Institute in Lyon, France, held a plaque-unveiling ceremony. Thomas Boutonnet, a Frenchman who has studied Chinese for 10 years in France and China and who is also an institute supervisor, said the institute would offer courses in Chinese language and culture covering legal, wade and cultural fields.

  10. FROM THE CHINESE PRESS

    Institute of Scientific and Technical Information of China (English)

    1998-01-01

    Equality and harmony are mainstream in Chinese marriage. The conclusion was made by a systematic investigation in 1996 on love and marriage relations between couples in Shanghai, Harbin, Guangdong, Gansu and other regions. Six thousand couples were surveyed in a multi-period, separated level probability sampling; the research was conducted by the study group, "Marriage quality during the period of Chinese social

  11. Say That in Chinese

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Demand for Chinese language learning is fueling all aspects of the market, most notably the textbook publication industry Alarge-scale series of Chinese lan-guage textbooks are to be pub-lished in the coming years jointly by the China International Publi

  12. On Developing Business Chinese.

    Science.gov (United States)

    Hong, Wei

    1996-01-01

    Examines the significance of foreign languages for business, particularly Business Chinese, in the 1990s; its curriculum requirements; and the impact of business languages on international business. The article proposes a developmental plan for Business Chinese at the college level including goals, course materials, learning activities, and…

  13. Chinese by Choice

    Science.gov (United States)

    Beem, Kate

    2008-01-01

    A 2004 College Board survey revealed that school districts around America wanted to offer Chinese, but finding qualified teachers was a problem, says Selena Cantor, director of Chinese Language and Culture Initiatives for the College Board. So last year, a new College Board program brought guest teachers from China to school districts in 31…

  14. Equilibria of Chinese Auctions

    DEFF Research Database (Denmark)

    Branzei, Simina; Forero, Clara; Larson, Kate;

    Chinese auctions are a combination between a raffle and an auction and are held in practice at charity events or festivals. In a Chinese auction, multiple players compete for several items by buying tickets, which can be used to win the items. In front of each item there is a basket, and the play...

  15. PBL and critical thinking disposition in Chinese medical students

    DEFF Research Database (Denmark)

    Du, Xiangyun; Emmersen, Jeppe; Toft, Egon;

    2013-01-01

    ) were randomized to PBL or non-PBL teaching at the commencement of the study. After five years of study, CT was scored by a Chinese version of the California Critical Thinking Disposition Inventory (CCTDI-CV). The score achieved on a Computer Case Simulation (CCS) test evaluated academic performance......The purpose of this study was to explore the relationship of problem-based learning (PBL) and the development of critical thinking disposition (CT) and academic achievement in Chinese medical students using a cross-sectional randomized design. Medical students from China Medical University (CMU...... scores and CCTDI-CV results. Male students scored slightly higher on the CCS test compared to female students (male 113.4±18.9 vs. female 109.7±19.7), but the difference was not significant. This study concludes that in Chinese medical students, PBL teaching was related to a higher disposition of...

  16. Factorial Structure of the Anxiety Control Questionnaire in Chinese Adolescents

    Science.gov (United States)

    Shujuan, Wang; Meihua, Qian; Jianxin, Zhang

    2009-01-01

    This article examines the psychometric structure of the Anxiety Control Questionnaire (ACQ) in Chinese adolescents. With the data collected from 212 senior high school students (94 females, 110 males, 8 unknown), seven models are tested using confirmatory factor analyses in the framework of the multitrait-multimethod strategy. Results indicate…

  17. Measurement of the volume of internal capsule in healthy Chinese adults of the Han nationality on the high-resolution MRI

    International Nuclear Information System (INIS)

    Objective: To explore the normal range of the volume of internal capsules in Chinese adults of the Han nationality and its relationship with age, body habitus, and craniocerebral volume. Methods: One thousand healthy volunteers (age range =18 to 80 years) were divided into 5 groups according to their age; Group A (18 to 30 years old), group B (31 to 40 years), group C (41 to 50 years), group D (51 to 60 years), and group E (61 to 80 years). Each group consisted of 100 males and 100 females. MR imaging was performed in all of the volunteers using T1 weighted three-dimensional magnetization prepared rapid acquisition gradient echo sequence. After three dimension data reconstruction, the volumes of bilateral internal capsules were manually measured. The volumes of bilateral internal capsules were compared by paired sample t test. The internal capsule volumes were compared between male and female by independent sample t test, and the differences among 5 age groups were compared by one-way ANOVA. The relationship between the volumes of internal capsule and age, body habitus or cerebral volume were analyzed using bivariate correlation. Results: The left and right internal capsule volumes were (2809 ± 393) and (2677 ± 343 ) mm3 respectively. The left internal capsule volumes were significantly larger than that of right (t=12.078, P<0.05). The left and right side of internal capsule volumes in male were (2863 ± 396) and (2744 ±358) mm3 respectively, and (2754 ±385) and (2609 ±314) mm3 in female. The left and right internal capsule volumes were larger in males than in female (t=1.982, 2.851; P<0.05). The left internal capsule volume of the 5 age groups were (3273 ± 361), (2943 ± 299), (2777 ± 255), (2607 ± 199), (2444 ±213) mm3, and the right were (2993 ± 361), (2814 ± 270), (2682 ± 239), (2543 ± 219), (2351 ±210) mm3. There were significant differences among 5 age groups between left and right internal capsule volume (F=55.244, 34.493; P<0.05). There was

  18. Modern Chinese History Studies

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    Famous Foreign Scholars' Lecture Tours in China Around the May Fourth Movement and Changes in Chinese Intellectual Circles From 1919 to 1924, John Dewey and four other famous foreign scholars came to China on lecture tours. These tours were great cultural undertakings to spread Western learning to the East after the First World War. The lectures these schol- ars gave helped to deepen the thoughts of Chinese people, and at the same time encouraged the diversification and evolution of Chinese intellectual circles. Firstly, the lectures hastened the birth of a contemporary Chinese wave of reflection on mo- dernity, and provided a basis for the theoretical views and cultural appeals of Liang Qichao and other members of the socalled "Orient Culture Faction," thereby increasing the tension intrinsic to the development of the New Culture Movement and to the expansion of intellectual horizons in Chinese intellectual circles.

  19. Chinese Companies in Switzerland

    Directory of Open Access Journals (Sweden)

    Esther Kessler

    2014-10-01

    Full Text Available In recent years, some of China’s leading firms have made headlines with their European expansion, by either opening new facilities or by acquiring or merging with significant enterprises in Europe. The goal of this paper is to contribute to the existing literature by examining Chinese enterprises expanding into Switzerland. The study also allows some conclusions for Chinese companies entering Central and Eastern Europe. We analyze via interviews the motivations of Chinese companies to expand into Switzerland as well as their behavior and the impediments in their internationalization process. Our findings show that Chinese companies fail to take advantage of certain benefits of western economies (such as open information and stable rule of law. To move forward efficiently, they should develop competence in dealing systematically with readily available market information, building professional networks that recognize a separation between business life and personal life, and managing their Chinese and foreign employees in the foreign cultural environment.

  20. On Chinese Parody Translation

    Institute of Scientific and Technical Information of China (English)

    熊俊

    2013-01-01

    Chinese parody, as a traditional figure of speech, has captured more and more attention from scholars. The researches conducted up to date are inadequate in theorizing and exploring its translation. This paper, based on the comparative data analysis of Chinese parody translation examples in different types of texts, attempts to probe into the means about how to achieve the clos⁃est function equivalence in rendering Chinese parody under the guidance of Sociosemiotic Approach. It is found that the nature of Chinese parody translation is to achieve the closest natural equivalence or similarity in expressive function, informative func⁃tion, vocative function and aesthetic function in its equivalents in English. And it is suggested that borrowing, imitating, para⁃phrasing and adapting are effective strategies in translating Chinese parody.