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Sample records for chinese herbal formula

  1. Hexa-herbal Chinese formula for eczema

    DEFF Research Database (Denmark)

    Chang, J.; Jäger, Anna; Heinrich, M.

    2014-01-01

    Diverse pharmacological activities and reliable clinical performances of Chinese herbal medicines have attracted worldwide attention in terms of its modernization. Here, a hexa-herbal Chinese formula (HHCF) for treating eczema topically has been studied from both chemical and biological perspective...... colonizes the skin of most patients with AD and produces superantigens that could further increase severity of AD via subverting T-regulatory cell activity and inducing corticosteroid resistance. [3] Therefore, activity of the decoctions prepared from mixture and individual medicinal plants of the formula...

  2. Modern use of Chinese herbal formulae from Shang-Han Lun

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    CHEN Fang-pey; CHEN Fun-jou; JONG Maw-shiou; TSAI Hui-lin; WANG Jen-ren; HWANG Shinn-jang

    2009-01-01

    Background The Chinese medical archive,Shang-Han Lun,is said to be written by ZHANG Zhong-jing (150-219 A.D.).This great influential work introduced the specific symptoms of six-channel disorders (Tai-Yang,Yang-Ming,Shao-Yang,Tai-Yin,Shao-Yin,and Jue-Yin) and their corresponding treatments,the combined syndromes,deterioration due to malpractice,and the concept of six-channel transitions.The concept of Shang-Han Lun is widely accepted by Chinese herbal doctors.However,no clinical data about Shang-Han symptoms are described in oriental or western medical reports.Methods The clinical prescription data of traditional Chinese medicine visits were extracted under the National Health Insurance in Taiwan.The application rate of 42 Shang-Han formulae in clinical practice was analyzed in detail with the software SPSS.Results Between 1999 and 2002,the prescription rate of Shang-Han formula was only 5.22% among a total of 528 889 576 Chinese herbal formula prescriptions.The most frequently used formula was Tai-Yang formulae (71.31%),followed by Shao-Yang formulae (17.49%) and the most commonly prescribed individual Shang-Han formulae were Ge-Gen Tang (16.11%),Shao-Yao-Gan-Cao Tang (12.97%),Xiao-Qing-Long Tang (11.79%),Ban-Xia Xie-Xin Tang (10.24%),and Xiao-Chai-Hu Tang (9.11%),which comprised 60.22% of the utilization rate of total Shang-Han formulae.Conclusions From the prescription patterns of Shang-Han formulae,there was no evidence of transitions among the six channels.Despite the fundamental role of Shang-Han Lun in traditional Chinese medicine,prescription of Shang-Han formulae was limited in clinical practice.

  3. Quality assurance for Chinese herbal formulae: standardization of IBS-20, a 20-herb preparation

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    Bensoussan Alan

    2010-02-01

    Full Text Available Abstract Background The employment of well characterized test samples prepared from authenticated, high quality medicinal plant materials is key to reproducible herbal research. The present study aims to demonstrate a quality assurance program covering the acquisition, botanical validation, chemical standardization and good manufacturing practices (GMP production of IBS-20, a 20-herb Chinese herbal formula under study as a potential agent for the treatment of irritable bowel syndrome. Methods Purity and contaminant tests for the presence of toxic metals, pesticide residues, mycotoxins and microorganisms were performed. Qualitative chemical fingerprint analysis and quantitation of marker compounds of the herbs, as well as that of the IBS-20 formula was carried out with high-performance liquid chromatography (HPLC. Extraction and manufacture of the 20-herb formula were carried out under GMP. Chemical standardization was performed with liquid chromatography-mass spectrometry (LC-MS analysis. Stability of the formula was monitored with HPLC in real time. Results Quality component herbs, purchased from a GMP supplier were botanically and chemically authenticated and quantitative HPLC profiles (fingerprints of each component herb and of the composite formula were established. An aqueous extract of the mixture of the 20 herbs was prepared and formulated into IBS-20, which was chemically standardized by LC-MS, with 20 chemical compounds serving as reference markers. The stability of the formula was monitored and shown to be stable at room temperature. Conclusion A quality assurance program has been developed for the preparation of a standardized 20-herb formulation for use in the clinical studies for the treatment of irritable bowel syndrome (IBS. The procedures developed in the present study will serve as a protocol for other poly-herbal Chinese medicine studies.

  4. Anti-Inflammatory Effects of the Chinese Herbal Formula Sini Tang in Myocardial Infarction Rats

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    Jiangang Liu

    2014-01-01

    Full Text Available The aim of this study was to evaluate the anti-inflammatory profiling of the Chinese herbal formula Sini Tang (SNT in myocardial infarction (MI rats. SNT, a decoction consisting of four herbs: Aconitum carmichaelii, Cinnamomum cassia, Zingiber officinale, and Glycyrrhiza uralensis, was characterized as a remedy to treat syndromes corresponding to heart failure and MI in China. Potential biomarkers, which reflect the extent of myocardial necrosis and correlate with cardiac outcomes following MI, such as atrial natriuretic peptide (ANP, high sensitivity C-reactive protein (hs-CRP, and proinflammatory cytokines such as tumor necrosis factor-α, interleukin-6, and interleukin-1β (TNF-α, IL-6, and IL-1β were determined in plasma, serum, and in myocardial tissue of MI rats after treatment with SNT. Our data indicate that SNT decreased significantly the levels of hs-CRP, TNF-α, IL-6, and IL-1β in MI rats. SNT decreased the expression of ANP levels in plasma and increased the vascular active marker nitric oxide, which limits vascular inflammation. In addition, SNT could decrease the expression of endothelin-1 levels in rat plasma post-MI. Our data suggest that the Chinese herbal formula SNT has the potential to improve cardiac function after MI. SNT may be a candidate for treating MI and its associated inflammatory responses.

  5. Structural modulation of gut microbiota during alleviation of type 2 diabetes with a Chinese herbal formula.

    Science.gov (United States)

    Xu, Jia; Lian, Fengmei; Zhao, Linhua; Zhao, Yufeng; Chen, Xinyan; Zhang, Xu; Guo, Yun; Zhang, Chenhong; Zhou, Qiang; Xue, Zhengsheng; Pang, Xiaoyan; Zhao, Liping; Tong, Xiaolin

    2015-03-01

    The gut microbiota is hypothesized to have a critical role in metabolic diseases, including type 2 diabetes (T2D). A traditional Chinese herbal formula, Gegen Qinlian Decoction (GQD), can alleviate T2D. To find out whether GQD modulates the composition of the gut microbiota during T2D treatment, 187 T2D patients were randomly allocated to receive high (HD, n=44), moderate (MD, n=52), low dose GQD (LD, n=50) or the placebo (n=41) for 12 weeks in a double-blinded trial. Patients who received the HD or MD demonstrated significant reductions in adjusted mean changes from baseline of fasting blood glucose (FBG) and glycated hemoglobin (HbA1c) compared with the placebo and LD groups. Pyrosequencing of the V3 regions of 16S rRNA genes revealed a dose-dependent deviation of gut microbiota in response to GQD treatment. This deviation occurred before significant improvement of T2D symptoms was observed. Redundancy analysis identified 47 GQD-enriched species level phylotypes, 17 of which were negatively correlated with FBG and 9 with HbA1c. Real-time quantitative PCR confirmed that GQD significantly enriched Faecalibacterium prausnitzii, which was negatively correlated with FBG, HbA1c and 2-h postprandial blood glucose levels and positively correlated with homeostasis model assessment of β-cell function. Therefore, these data indicate that structural changes of gut microbiota are induced by Chinese herbal formula GQD. Specifically, GQD treatment may enrich the amounts of beneficial bacteria, such as Faecalibacterium spp. In conclusion, changes in the gut microbiota are associated with the anti-diabetic effects of GQD.

  6. An analysis of chemical ingredients network of Chinese herbal formulae for the treatment of coronary heart disease.

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    Fan Ding

    Full Text Available As a complex system, the complicated interactions between chemical ingredients, as well as the potential rules of interactive associations among chemical ingredients of traditional Chinese herbal formulae are not yet fully understood by modern science. On the other hand, network analysis is emerging as a powerful approach focusing on processing complex interactive data. By employing network approach in selected Chinese herbal formulae for the treatment of coronary heart disease (CHD, this article aims to construct and analyze chemical ingredients network of herbal formulae, and provide candidate herbs, chemical constituents, and ingredient groups for further investigation. As a result, chemical ingredients network composed of 1588 ingredients from 36 herbs used in 8 core formulae for the treatment of CHD was produced based on combination associations in herbal formulae. In this network, 9 communities with relative dense internal connections are significantly associated with 14 kinds of chemical structures with P<0.001. Moreover, chemical structural fingerprints of network communities were detected, while specific centralities of chemical ingredients indicating different levels of importance in the network were also measured. Finally, several distinct herbs, chemical ingredients, and ingredient groups with essential position in the network or high centrality value are recommended for further pharmacology study in the context of new drug development.

  7. Effects of Chinese herbal formula Erxian decoction for treating osteoporosis: a systematic review

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    Li J

    2017-01-01

    Full Text Available Jin-Yu Li,1,* Yu-Song Jia,1,* Li-Min Chai,1 Xiao-Hong Mu,1 Sheng Ma,1 Lin Xu,1 Xu Wei21Department of Orthopaedics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 2Department of Scientific Research, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China *These authors contributed equally to this workPurpose: The aim is to systematically assess the effectiveness and safety of Chinese herbal formula Erxian decoction (EXD for treating osteoporosis. Materials and methods: Six databases were searched from inception through September 17, 2016, without language restriction. All randomized controlled trials of EXD for osteoporosis were included. One or more outcome measures including fracture, change in bone mineral density (BMD, pain symptom improvement, bone biochemical markers, quality of life, adverse event or adverse drug reaction were evaluated. Study selection, data extraction, quality assessment, and data analyses were conducted according to Cochrane standards. Results: Eight trials including 644 patients investigated the effects of EXD in the treatment of osteoporosis. The methodological quality of the included trials was generally low. The meta-analysis from two trials showed favorable effects of EXD in improving BMD of lumbar spine (mean difference [MD]: 0.05 [0.03, 0.06]; I2=0%; P<0.00001 and BMD of femoral great trochanter (MD: 0.06 [0.02, 0.10]; I2=59%; P=0.005 compared with caltrate tablets. The other meta-analysis from two trials showed beneficial effects of EXD plus caltrate tablets and calcitriol in improving BMD of femoral neck (MD: 0.04 [0.00, 0.09]; I2=56%; P=0.04, the level of calcium (MD: 0.20 [0.15, 0.24]; I2=0%; P<0.00001, and phosphorus (MD: −0.28 [−0.39, −0.17]; I2=68%; P<0.00001 compared with caltrate tablets and calcitriol alone. The adverse drug reactions of EXD were mainly slight gastrointestinal symptoms.Conclusion: The

  8. Cognitive Improvement during Treatment for Mild Alzheimer's Disease with a Chinese Herbal Formula: A Randomized Controlled Trial.

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    Yulian Zhang

    Full Text Available To explore the efficacy of Chinese herbal formula compared with donepezil 5 mg/day in patients with mild Alzheimer's disease (AD.Patients with mild AD meeting the criteria were randomized into Chinese herbal formula Yishen Huazhuo decoction (YHD group and donepezil hydrochloride (DH group during the 24-week trial. The outcomes were measured by ADAS-cog, MMSE, ADL, and NPI with linear mixed-effect models.144 patients were randomized. The mean scores of ADAS-cog and MMSE in both YHD group and DH group both improved at the end of the 24-week treatment period. The results also revealed that YHD was better at improving the mean scores of ADAS-cog and MMSE than DH. Linear mixed-effect models with repeated measures showed statistical significance in time × group interaction effect of ADAS-cog and also in time × group interaction effect of MMSE. The data showed YHD was superior to DH in improving the scores and long term efficacy.Our study suggests that Chinese herbal formula YHD is beneficial and effective for cognitive improvement in patients with mild AD and the mechanism might be through reducing amyloid-β (Aβ plaque deposition in the hippocampus.Chinese Clinical Trial Registry ChiCTR-TRC-12002846.

  9. Effects of Chinese herbal formula Erxian decoction for treating osteoporosis: a systematic review

    Science.gov (United States)

    Li, Jin-Yu; Jia, Yu-Song; Chai, Li-Min; Mu, Xiao-Hong; Ma, Sheng; Xu, Lin; Wei, Xu

    2017-01-01

    Purpose The aim is to systematically assess the effectiveness and safety of Chinese herbal formula Erxian decoction (EXD) for treating osteoporosis. Materials and methods Six databases were searched from inception through September 17, 2016, without language restriction. All randomized controlled trials of EXD for osteoporosis were included. One or more outcome measures including fracture, change in bone mineral density (BMD), pain symptom improvement, bone biochemical markers, quality of life, adverse event or adverse drug reaction were evaluated. Study selection, data extraction, quality assessment, and data analyses were conducted according to Cochrane standards. Results Eight trials including 644 patients investigated the effects of EXD in the treatment of osteoporosis. The methodological quality of the included trials was generally low. The meta-analysis from two trials showed favorable effects of EXD in improving BMD of lumbar spine (mean difference [MD]: 0.05 [0.03, 0.06]; I2=0%; Posteoporosis. However, the evidence remains weak. More rigorously designed and measured, randomized double-blind, placebo-controlled trials with larger sample size are needed to verify the current conclusions. PMID:28115834

  10. Effectiveness and Safety of Manufactured Chinese Herbal Formula for Knee Osteoarthritis: Insights from a Systematic Review

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    Liguo Zhu

    2015-01-01

    Full Text Available Objective. To assess the current clinical evidence of manufactured Chinese herbal formulae (MCHF for knee osteoarthritis (KOA. Methods. Seven databases were searched from inception to May 2015. Eligible randomized controlled trials investigating the effectiveness of MCHF for KOA were included. Data extraction, methodological assessment, and meta-analyses were conducted according to the Cochrane standards. Results. A total of 17 kinds of MCHF were identified from the twenty-six included trials. Meta-analyses showed that MCHF significantly relieved the global pain of knee joints, either used alone or combined with routine treatments. Additionally, MCHF plus routine treatments significantly decreased the scores of WOMAC and Lequesne index. However, there were no statistical differences between MCHF group and routine treatment group in walk-related pain and WOMAC scores. No significant differences were found in Lysholm scores. There were twenty-one trials that mentioned adverse events. A pooled analysis showed that adverse events occurred more frequently in control group compared with MCHF group. Conclusions. Our results indicated that MCHF showed some potential benefits for KOA. However, we still cannot draw firm conclusions due to the poor methodological quality of included trials. More high-quality RCTs would help to confirm the evidence.

  11. Anti-Inflammatory Activities of a Chinese Herbal Formula IBS-20 In Vitro and In Vivo

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    Zhonghan Yang

    2012-01-01

    Full Text Available Irritable bowel syndrome (IBS is a functional bowel disorder and the etiology is not well understood. Currently there is no cure for IBS and no existing medication induces symptom relief in all patients. IBS-20 is a 20-herb Chinese medicinal formula that offers beneficial effects in patients with IBS; however, the underlying mechanisms are largely unknown. This study showed that IBS-20 potently inhibited LPS- or IFNΓ-stimulated expression of pro-inflammatory cytokines, as well as classically activated macrophage marker nitric oxide synthase 2. Similarly, IBS-20 or the component herb Coptis chinensis decreased LPS-stimulated pro-inflammatory cytokine secretion from JAWS II dendritic cells. IBS-20 or the component herbs also blocked or attenuated the IFNΓ-induced drop in transepithelial electric resistance, an index of permeability, in fully differentiated Caco-2 monolayer. Finally, the up-regulation of key inflammatory cytokines in inflamed colon from TNBS-treated mice was suppressed significantly by orally administrated IBS-20, including IFNΓ and IL-12p40. These data indicate that the anti-inflammatory activities of IBS-20 may contribute to the beneficial effects of the herbal extract in patients with IBS, providing a potential mechanism of action for IBS-20. In addition, IBS-20 may be a potential therapeutic agent against other Th1-dominant gut pathologies such as inflammatory bowel disease.

  12. Effects of Chinese herbal formula Heat-stress-releasing on antioxidant function in dairy cows

    Institute of Scientific and Technical Information of China (English)

    ZHANG Qingru; NI Yaodi; GUO Hongbin; WANG Chunguang

    2007-01-01

    In order to investigate the effects of a Chinese herbal formula Heat-stress-releasing on the antioxidant function in dairy cows,ten dairy cows were randomly divided into the control group and the experimental group,with five cows in each group.All the cows were fed with a basal diet.The animals in the experimental group were given with 220 g of herbs per day in addition to the basal diet.The trial was conducted for 14 days.Blood samples were taken from the vena cava at day 0,day 7,and day 15,respectively.The antioxidant statuses were examined.The results are as follows.(1) Heat-Stress-releasing formula can significantly increase the milk yield of dairy cows under heat stress.Compared with the control group,the milk yield of the herb-treated group increased by 14.01% (P<0.05),14.32% (P<0.05) and 15.01% (P<0.05) in prophase,metaphase and anaphase of the test,respectively.(2) Heat-Stress-releasing formula can increase significantly the antioxidant status of the heat stressed dairy cows.Compared with the control group,the superoxide dismutase (SOD) activity increased by 45.93% (P<0.01) at day 7 and by 54.40% (P<0.01) at day 15.The Glutathione-peroxidase (GSH-PX) activity of the test group increased by 17.99% (P<0.05) at day 7 and 25.98% (P<0.01) at day 15.The total antioxidant capacity (T-AOC) of the test group increased by 43.64% (P<0.01) at day 7 and 46.35% (P<0.01)at day 15.The malondaldehyd (MDA) content of test group declined by 23.88% (P<0.01) at day 7 and 25.32% (P<0.01)at day 15.

  13. Antidiarrheal properties of different extracts of Chinese herbal medicine formula Bao-Xie-Ning

    Institute of Scientific and Technical Information of China (English)

    Jing Li; Xin-lin Wu; Yuling Chen; Zhi Tang; Yue-hong Xu; Jian-min Jiang; Yue-yu Gu

    2013-01-01

    OBJECTIVE:Bao-Xie-Ning (BXN),a traditional Chinese herbal medicine (CHM) formula composed of Fructus Evodiae,Flos Caryophylli and Cortex Cinnamomi,and used for the treatment of infant diarrheal illness,was subject to systematic assessment for its putative multiple pharmacodynamic effects and pharmacological antidiarrheal mechanisms.METHODS:High-performance liquid chromatography-diode array detector-electrospray ionizationmass spectrometric/mass spectrometry was developed and validated for identification and quantification of the main constituents in different extracts of BXN.Male Kunming mice weighing 20 to 25 g were used for detecting the antidiarrheal activity of the extracts.Ethanolic extract (EE),volatile oil extract (VOE),and aqueous extract (AE) of BXN were respectively subjected to pharmacodynamic and pharmacological comparison in assessing antidiarrheal effects with senna-induced diarrhea,castor oil-induced diarrhea,acetic acid-induced writhing assay,and isolated duodenum test.RESULTS:The highest yields of three detected components of BXN,rutaecarpine,eugenol and cinnamaldehyde were observed in EE.EE showed the most remarkable antidiarrheal activity in dose-dependent and time-dependent manners in both senna-and castor oil-induced diarrhea models,and presented dose-dependent analgesic activity in acetic acid-induced algesthesia model.In addition,EE extract of BXN also exhibited strong antimobility action on the intestine and strongest depression on spontaneous contraction of isolated duodenum.CONCLUSION:Ethanol extraction is an efficient method to extract the active constituents of BXN.BXN extract demonstrated multiple pharmacological activities affecting the main mechanisms of diarrhea,which validated BXN's usage in the comprehensive clinical treatment of diarrhea.

  14. Liuwei Dihuang, a traditional Chinese herbal formula, suppresses chronic inflammation and oxidative stress in obese rats

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    Benjamin Perry; Junzeng Zhang; Tarek Saleh; Yanwen Wang

    2014-01-01

    OBJECTIVE:To investigate the anti-inlfammatory, anti-oxidative stress, and adipokine-ameliorating effects of Liuwei Dihuang (LWDH), a traditional Chinese herbal formula, in obese rats. METHODS:After 2 weeks of acclimation with free access to regular rodent chow and water, obese-prone-caesarean-derived (OP-CD) rats were fed a modified AIN-93G diet containing 60% energy from fat. Treatment was performed twice daily by gavage feeding with 500, 1 500, or 3 500 mg/kg body weight LWDH suspended in water (n=12 rats per group). Twelve obese-resistant-CD (OR-CD) rats were fed the atherogenic diet and gavaged with water, and served as the normal control. Blood biomarkers of inflammation, oxidative stress and adiponectin were measured post-sacriifce and used to determine the treatment effect of LWDH and assess the suitability of OR/OP-CD rats for studying these parameters. RESULTS:After 9 weeks of treatment, LWDH lowered serum C-reactive protein (CRP) and tumour necrosis factor-α (TNF-α) levels. Serum interleukin-6 (IL-6) levels showed a tendency towards reduction, but were not signiifcantly different from the OP-CD control. Liver superoxide dismutase (SOD) activity was increased in response to all three doses of LWDH, while the levels of reduced (GSH) and oxidized glutathione (GSSG) and thiobarbituric acid reactive substances (TBARS) were unchanged. Serum adiponectin levels were increased in response to oral administration of LWDH at the dose of either 500 or 1 500 mg/kg body weight. In addition, comparisons between OR-CD and OP-CD rats revealed differential, and for some biomarkers, conflicting characteristics of high-fat diet-fed OP-CD rats in reference to obese human subjects in terms of inlfammatory and oxidative stress biomarkers and circulating adiponectin levels. CONCLUSION: The results show, for the ifrst time, the anti-inlfammatory, anti-oxidative stress and adiponectin-ameliorating effects of LWDH in obese rats. The suitability of the OR/OP-CD rat model as a

  15. Material basis of Chinese herbal formulas explored by combining pharmacokinetics with network pharmacology.

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    Lixia Pei

    Full Text Available The clinical application of Traditional Chinese medicine (TCM, using several herbs in combination (called formulas, has a history of more than one thousand years. However, the bioactive compounds that account for their therapeutic effects remain unclear. We hypothesized that the material basis of a formula are those compounds with a high content in the decoction that are maintained at a certain level in the system circulation. Network pharmacology provides new methodological insights for complicated system studies. In this study, we propose combining pharmacokinetic (PK analysis with network pharmacology to explore the material basis of TCM formulas as exemplified by the Bushen Zhuanggu formula (BZ composed of Psoralea corylifolia L., Aconitum carmichaeli Debx., and Cnidium monnieri (L. Cuss. A sensitive and credible liquid chromatography tandem mass spectrometry (LC-MS/MS method was established for the simultaneous determination of 15 compounds present in the three herbs. The concentrations of these compounds in the BZ decoction and in rat plasma after oral BZ administration were determined. Up to 12 compounds were detected in the BZ decoction, but only 5 could be analyzed using PK parameters. Combined PK results, network pharmacology analysis revealed that 4 compounds might serve as the material basis for BZ. We concluded that a sensitive, reliable, and suitable LC-MS/MS method for both the composition and pharmacokinetic study of BZ has been established. The combination of PK with network pharmacology might be a potent method for exploring the material basis of TCM formulas.

  16. TRADITIONAL CHINESE HERBAL MEDICINE

    NARCIS (Netherlands)

    ZHU, YP; WOERDENBAG, HJ

    1995-01-01

    Herbal medicine, acupuncture and moxibustion, and massage and the three major constituent parts of traditional Chinese medicine. Although acupuncture is well known in many Western countries, Chinese herbal medicine, the mos important part of traditional Chinese medicine, is less well known in the We

  17. Comparison of Chinese herbal medicine and TCM formula granules%中药饮片和中药配方颗粒的比较

    Institute of Scientific and Technical Information of China (English)

    安学荣; 建福

    2014-01-01

    To compare Chinese herbal medicine with TCM formula granules from each according to the principle, quality control, allocation of storage.%从依据原则、质量控制、调配储存等各个方面比较中药饮片和中药配方颗粒。

  18. Effects of Chinese herbal medicine Yiqi Huaju Formula on hypertensive patients with metabolic syndrome: a randomized, placebo-controlled trial

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    Yi Chen; De-yu Fu; Yu Chen; Yan-ming He; Xiao-dong Fu; Yan-qiu Xu; Yi Liu

    2013-01-01

    BACKGROUND:Patients with hypertension coupled with metabolic syndrome (MetS) are among the high risk population in cardiovascular and cerebrovascular diseases.To reduce the prevalence of cardiovascular and cerebrovascular diseases,it is essential to appropriately control blood pressure together with other cardiovascular risk factors.OBJECTIVE:The current study was designed to investigate the therapeutic effects on blood pressure,blood pressure variability and other cardiovascular risk factors by giving Yiqi Huaju Formula,a compound traditional Chinese herbal medicine,in addition to routine treatment to hypertensive patients coupled with MetS.DESIGN,SETTING,PARTICIPANTS AND INTERVENTIONS:A total of 43 patients with hypertension coupled with MetS were recruited into this study.The enrolled patients were randomly divided into the Chinese herbal formula group (anti-hypertensive drugs plus Yiqi Huaju Formula,CHF) and the control group (anti-hypertensive drugs plus placebo).The CHF group enrolled 22 patients while the control group received 21 cases.Treatments were given for 12 weeks in both groups.MAIN OUTCOME MEASURES:Parameters examined include 24-hour ambulatory blood pressure monitoring,body mass index,waist circumference,waist-to-hip ratio,homeostatic model assessment for insulin resistance (HOMA-IR),fasting glycosylated hemoglobin (HbA1c),fasting plasma glucose,2-hour postprandial plasma glucose (PPG),fasting plasma insulin,serum lipid,etc.RESULTS:Compared with the control group,the CHF group had significant improvement (P<0.01) in anthropometric parameters,FPG,HOMA-IR,blood pressure amplitude,blood pressure variability and blood pressure load.CONCLUSION:This study showed that integrated traditional Chinese and Western medicine treatment can achieve better results in controlling blood pressure as well as other cardiovascular risk factors.The mechanism of controlling of blood pressure may be associated with the improvement of insulin sensitivity due to the Yiqi

  19. Determination of Bioactive Components in Chinese Herbal Formulae and Pharmacokinetics of Rhein in Rats by UPLC-MS/MS

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    Mei-Ling Hou

    2014-04-01

    Full Text Available Rhein (4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid, cassic acid is a pharmacological active component found in Rheum palmatum L. the major herb of San-Huang-Xie-Xin-Tang (SHXXT, a medicinal herbal product used as a remedy for constipation. Here we have determined multiple bioactive components in SHXXT and investigated the comparative pharmacokinetics of rhein in rats. A sensitive and specific method combining liquid chromatography with electrospray ionization tandem mass spectrometry has been developed and validated to simultaneously quantify six active compounds in the pharmaceutical herbal product SHXXT to further study their pharmacokinetics in rats. Multiple reaction monitoring (MRM was employed for quantification with switching electrospray ion source polarity between positive and negative modes in a single run. There were no significant matrix effects in the quantitative analysis and the mean recovery for rhein in rat plasma was 91.6% ± 3.4%. The pharmacokinetic data of rhein demonstrate that the herbal formulae or the single herbal extract provide significantly higher absorption rate than the pure compound. This phenomenon suggests that the other herbal ingredients of SHXXT and rhubarb extract significantly enhance the absorption of rhein in rats. In conclusion, the herbal formulae (SHXXT are more efficient than the single herb (rhubarb or the pure compound (rhein in rhein absorption.

  20. The add-on effect of a Chinese herbal formula for patients with resistant hypertension:study protocol for a pilot cohort study

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    Ya Yuwen; Yu-qi Liu; Yan-ping Wang; Jin-gang Dai; Da-sheng Liu; Yue-xi Wang; Xue-jie Han

    2015-01-01

    BACKGROUND:Despite a recent American Heart Association (AHA) consensus statement emphasizing the importance of resistant hypertension (RH), its control is stil a chal enge for conventional medicine. The Chinese herbal formula, Qutan Huayu Fang, has been used effectively to assist antihypertensive agents in blood pressure control, but its effect for RH patients is stil unclear. This pilot study aims to explore the effects of taking the formula in addition to antihypertensive medication in the management of RH. METHODS/DESIGN:A prospective cohort study wil be conducted in two ifrst-class hospitals of traditional Chinese medicine (TCM). Eligible RH patients wil be classiifed as the experimental group (n=100) and the control group (n=100) based on the interventions they receive. Participants taking antihypertensive agents and the Chinese herbal formula wil be in the experimental group and those taking antihypertensive agents alone wil be in the control group. The whole study wil last 24 weeks, including an 8-week observation and fol ow-up at 24 weeks. The primary outcomes, assessed against patient baseline conditions, wil be the reduction of systolic blood pressure and diastolic blood pressure as wel as changes in TCM symptoms and signs. These outcomes wil be assessed at weeks 2, 4, 6, and 8. The reductions of blood pressure wil also be assessed at week 24. Cardiac events and mortality rate wil be secondary outcomes and wil be assessed at weeks 8 and 24. Any adverse reactions wil be recorded during the study. The causal inference method wil be used to assess the effectiveness of the inclusion of TCM herbal medicine in the management of patients with RH. DISCUSSION:This study wil determine whether the Chinese herbal formula is helpful for RH patients treated with antihypertensive agents and the ifndings wil provide a basis for further conifrmatory studies. TRIAL REGISTRATION NUMBER:ClinicalTrials.gov Identiifer NCT01904695.

  1. Chinese herbal formula Tongluo Jiunao injection protects against cerebral ischemia by activating neurotrophin 3/tropomyosin-related kinase C pathway

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    Peiman Alesheikh

    2015-01-01

    Full Text Available The Chinese herbal formula Tongluo Jiunao, containing the active components Panax notoginseng and Gardenia jasminoides, has recently been patented and is in use clinically. It is known to be neuroprotective in cerebral ischemia, but the underlying pathway remains poorly understood. In the present study, we established a rat model of cerebral ischemia by occlusion of the middle cerebral artery, and administered Tongluo Jiunao, a positive control (Xuesai Tong, containing Panax notoginseng or saline intraperitoneally to investigate the pathway involved in the action of Tongluo Jiunao injection. 2,3,5-Triphenyltetrazolium chloride (TTC staining showed that the cerebral infarct area was significantly smaller in model rats that received Tongluo Jiunao than in those that received saline. Enzyme-linked immunosorbent assay revealed significantly greater expression of neurotrophin 3 and growth-associated protein 43 in ischemic cerebral tissue, and serum levels of neurotrophin 3, in the Tongluo Jiunao group than in the saline group. The reverse transcription polymerase chain reaction and immunohistochemical staining showed that after treatment with Tongluo Jiunao or Xuesai Tong, tropomyosin-related kinase C gene expression and immunoreactivity were significantly elevated compared with saline, with the greatest expression observed after Tongluo Jiunao treatment. These findings suggest that Tongluo Jiunao injection exerts a neuroprotective effect in rats with cerebral ischemia by activating the neurotrophin 3/tropomyosin-related kinase C pathway.

  2. In Vivo Study on the Pharmacological Interactions between a Chinese Herbal Formula ELP and Antiresorptive Drugs to Counteract Osteoporosis

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    Chun-Hay Ko

    2012-01-01

    Full Text Available Antiresorptive drugs, alendronate and raloxifene, are effective in lowering bone mineral density (BMD loss in postmenopausal women. However, long-term treatment may be associated with serious side effects. Our research group has recently discovered that a Chinese herbal formula, ELP, could significantly reduce BMD loss in animal and human studies. Therefore, the present study aimed to investigate the potential synergistic bone-protective effects of different herb-drug combinations using ovariectomized rats. To assess the efficacy of different combinations, the total BMD was monitored biweekly in the 8-week course of daily oral treatment. Bone microarchitecture, bone strength, and deoxypyridinoline level were also determined after 8 weeks. From our results, coadministration of ELP and raloxifene increased the total tibial BMD by 5.26% (2.5 mg/kg/day of raloxifene; P=0.014 and 5.94% (0.25 mg/kg/day of raloxifene; P=0.026 when compared with the respective dosage groups with raloxifene alone. Similar synergistic effects were also observed in BMD increase at distal femur (0.25 mg/kg/day; P=0.001 and reduction in urinary deoxypyridinoline crosslink excretion (2.5 and 0.25 mg/kg/day; both P=0.02. However, such interactions could not be observed in all alendronate-treated groups. Our data provide first evidence that ELP could synergistically enhance the therapeutic effects of raloxifene, so that the clinical dosage of raloxifene could be reduced.

  3. Bioactivity of five components of Chinese herbal formula Jiangzhi granules against hepatocellular steatosis

    Institute of Scientific and Technical Information of China (English)

    Hai-yan Song; Li Zhang; Jie-lu Pan; Li-li Yang; Guang Ji

    2013-01-01

    OBJECTIVE:This study aims to evaluate the bioactivity of five components of the traditional Chinese medicine complex prescription Jiangzhi granules against hepatocellular steatosis.METHODS:The five major components,including protopanaxadiol,tanshinone IIA,emodin,chlorogenic acid,and nuciferine,were extracted from Jiangzhi granules.Their cytotoxicity was assessed to determine the safe dose of each component for HepG2 cells.HepG2 cellular steatosis was induced using 1 mmol/L of free fatty acids (FFAs) for 24 h,and then treated with each component at high,intermediate,and low doses (500,50,and 5 μmol/L),respectively for another 24 h.The effects on HepG2 steatosis were observed directly under optical phase microscopy,or through oil red O staining and Nile red assays.In addition,the levels of reactive oxygen species (ROS) in the steatotic HepG2 cells with and without high-dose protopanaxadiol treatment were measured using fluorescent dye 2′,7′-dichlorodihydrofluorescein diacetate staining.RESULTS:No obvious cytotoxicity was observed in the HepG2 cells incubated with each of the five components at up to 500 μmol/L.At 24 h after incubation with FFAs,the HepG2 cells swelled and many lipid droplets accumulated.The lipid content was attenuated after 24 h of incubation with protopanaxadiol,tanshinone IIA,and emodin at 500 or 50 μmol/L (P < 0.05),especially with 500 μmol/L protopanaxadiol (P < 0.01).In addition,the ROS level was elevated in steatotic cells,but decreased after intervention with 500 μmol/L protopanaxadiol (P < 0.05).CONCLUSION:Protopanaxadiol,tanshinone IIA,and emodin alleviate hepatocellular steatosis in a dose-dependent manner,and oxidative stress regulation may partially contribute to the effects of protopanaxadiol.

  4. Erxian Tang(二仙汤)——Introduction of a Chinese Herbal Formula,Clinical Practice,and Experimental Studies

    Institute of Scientific and Technical Information of China (English)

    LI Jie-jia; LI Jack Thomas; FU Jian-ping

    2007-01-01

    Erxian Tang(二仙汤,EXT)is a Chinese herbal formula developed for the treatment of menopausal syndrome in women.In the past 50 years,EXT has shown positive efficacy in the treatment of many chronic diseases in TCM,involving syndrome types of Shen (肾) yin-yang deficiency,yin-deficiency caused yang-flourishing,and disharmony of Chong-Ren meridian.Experimental studies have revealed that EXT has multiple pharmacological actions on such multipie targets as hypothalamus-pituitary-target gland axis,immune function and free radical metabolism,etc.

  5. A randomised placebo-controlled trial of a traditional Chinese herbal formula in the treatment of primary dysmenorrhoea.

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    Lan Lan Liang Yeh

    Full Text Available BACKGROUND: Most traditional Chinese herbal formulas consist of at least four herbs. Four-Agents-Decoction (Si Wu Tang is a documented eight hundred year old formula containing four herbs and has been widely used to relieve menstrual discomfort in Taiwan. However, no specific effect had been systematically evaluated. We applied Western methodology to assess its effectiveness and safety for primary dysmenorrhoea and to evaluate the compliance and feasibility for a future trial. METHODOLOGY/PRINCIPAL FINDINGS: A randomised, double-blind, placebo-controlled, pilot clinical trial was conducted in an ad hoc clinic setting at a teaching hospital in Taipei, Taiwan. Seventy-eight primary dysmenorrheic young women were enrolled after 326 women with self-reported menstrual discomfort in the Taipei metropolitan area of Taiwan were screened by a questionnaire and subsequently diagnosed by two gynaecologists concurrently with pelvic ultrasonography. A dosage of 15 odorless capsules daily for five days starting from the onset of bleeding or pain was administered. Participants were followed with two to four cycles for an initial washout interval, one to two baseline cycles, three to four treatment cycles, and three follow-up cycles. Study outcome was pain intensity measured by using unmarked horizontal visual analog pain scale in an online daily diary submitted directly by the participants for 5 days starting from the onset of bleeding or pain of each menstrual cycle. Overall-pain was the average pain intensity among days in pain and peak-pain was the maximal single-day pain intensity. At the end of treatment, both the overall-pain and peak-pain decreased in the Four-Agents-Decoction (Si Wu Tang group and increased in the placebo group; however, the differences between the two groups were not statistically significant. The trends persisted to follow-up phase. Statistically significant differences in both peak-pain and overall-pain appeared in the first follow

  6. Chinese herbal medicine for treatment of dislipidemia

    Institute of Scientific and Technical Information of China (English)

    Haiyun Wu; Jianwei Bei; Jiao Guo

    2009-01-01

    Prevalence of dislipidemia is increasing rapidly in China and there has been a growing interest in Chinese herbal medicine for the treatment of hyperlipidemia both inside and outside China. In this article, lipids regulating effects of 9 herbs or their extracts and 5 herbal formulae which have been published in English-language literature are reviewed. Although evidence from animals and humans consistently supports the therapeutic activities of these Chinese herbal medicines, few multi-center large-scale clinical trials have been conducted to confirm the efficacy and evaluate their safety.

  7. A Chinese Herbal Formula to Improve General Psychological Status in Posttraumatic Stress Disorder: A Randomized Placebo-Controlled Trial on Sichuan Earthquake Survivors

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    Xian-Ze Meng

    2012-01-01

    Full Text Available Introduction. Posttraumatic stress disorder (PTSD is accompanied by poor general psychological status (GPS. In the present study, we investigated the effects of a Chinese herbal formula on GPS in earthquake survivors with PTSD. Methods. A randomized, double-blind, placebo-controlled trial compared a Chinese herbal formula, Xiao-Tan-Jie-Yu-Fang (XTJYF, to placebo in 2008 Sichuan earthquake survivors with PTSD. Patients were randomized into XTJYF (n=123 and placebo (n=122 groups. Baseline-to-end-point score changes in the three global indices of the Symptom Checklist-90-Revised (SCL-90-R and rates of response in the SCL global severity index (GSI were the primary endpoints. A subanalysis of the nine SCL factors and the sleep quality score were secondary endpoints. Results and Discussion. Compared to placebo, the XTJYF group was significantly improved in all three SCL global indices (P = 0.001~0.028. More patients in the XTJYF group reported “much improved” than the placebo group (P = 0.001. The XTJYF group performed significantly better than control in five out of nine SCL factors (somatization, obsessive-compulsive behavior, depression, anxiety, and hostility (P = 0.001~0.036, and in sleep quality score (P<0.001. XTJYF produced no serious adverse events. These findings suggest that XTJYF may be an effective and safe treatment option for improving GPS in patients with PTSD.

  8. Thyroid hormone synthesis: a potential target of a Chinese herbal formula Haizao Yuhu Decoction acting on iodine-deficient goiter

    Science.gov (United States)

    Mao, Xia; Yan, Chen; Guo, Xiaodong; Guo, Qiuyan; Liu, Zhenli; Song, Zhiqian; Lin, Na

    2016-01-01

    Haizao Yuhu Decoction (HYD), a famous multi-component herbal formula, has been widely used to treat various thyroid-related diseases, including iodine-deficient goiter. Herb pair Thallus Sargassi Pallidi (HZ) and Radix Glycyrrhizae (GC), one of the so-called “eighteen antagonistic medicaments”, contains in HYD. To explore pharmacological mechanisms of HYD acting on iodine-deficient goiter and to provide evidence for potential roles of herb pair HZ and GC in HYD, our genome-wide microarray detection and network analysis identified a list of goiter-related genes, mainly involved into the alterations in hypothalamus-pituitary-thyroid/gonad/growth axes. Then, the disease genes-drug genes interaction network illustrated the links between HYD regulating genes and goiter-related genes, and identified the candidate targets of HYD acting on goiter. Functionally, these candidate targets were closely correlated with thyroid hormone synthesis. Moreover, the potential regulating genes of herb pair HZ and GC were revealed to be crucial components in the pathway of thyroid hormone synthesis. The prediction results were all verified by following experiments based on goiter rats. Collectively, this integrative study combining microarray gene expression profiling, network analysis and experimental validations offers the convincing evidence that HYD may alleviate iodine-deficient goiter via regulating thyroid hormone synthesis, and explains the necessity of herb pair HZ and GC in HYD. Our work provides a novel and powerful means to clarify the mechanisms of action for multi-component drugs such as herbal formulae in a holistic way, which may improve drug development and applications. PMID:27384475

  9. Systems pharmacology-based approach for dissecting the active ingredients and potential targets of the Chinese herbal Bufei Jianpi formula for the treatment of COPD

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    Zhao P

    2015-12-01

    Full Text Available Peng Zhao,1,2 Jiansheng Li,1,2 Ya Li,1,2 Yange Tian,1,2 Yonghua Wang,2,3 Chunli Zheng3 1Key Laboratory of Chinese Internal Medicine, Henan University of Traditional Chinese Medicine, 2Key Laboratory of Chinese Internal Medicine, Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment and Chinese Medicine Development of Henan Province, Zhengzhou, 3Center of Bioinformatics, College of Life Science, Northwest A&F University, Yangling, People’s Republic of China Background: The Chinese herbal Bufei Jianpi formula (BJF provides an effective treatment option for chronic obstructive pulmonary disease (COPD. However, the systems-level mechanism underlying the clinical effects of BJF on COPD remains unknown. Methods: In this study, a systems pharmacology model based on absorption filtering, network targeting, and systems analyses was applied specifically to clarify the active compounds and therapeutic mechanisms of BJF. Then, a rat model of cigarette smoke- and bacterial infection-induced COPD was used to investigate the therapeutic mechanisms of BJF on COPD and its comorbidity. Results: The pharmacological system successfully identified 145 bioactive ingredients from BJF and revealed 175 potential targets. There was a significant target overlap between the herbal constituents of BJF. These results suggested that each herb of BJF connected with similar multitargets, indicating potential synergistic effects among them. The integrated target–disease network showed that BJF probably was efficient for the treatment of not only respiratory tract diseases but also other diseases, such as nervous system and cardiovascular diseases. The possible mechanisms of action of BJF were related to activation of inflammatory response, immune responses, and matrix metalloproteinases, among others. Furthermore, we demonstrated that BJF treatment could effectively prevent COPD and its comorbidities, such as ventricular hypertrophy, by inhibition

  10. Systems pharmacology-based approach for dissecting the active ingredients and potential targets of the Chinese herbal Bufei Jianpi formula for the treatment of COPD

    Science.gov (United States)

    Zhao, Peng; Li, Jiansheng; Li, Ya; Tian, Yange; Wang, Yonghua; Zheng, Chunli

    2015-01-01

    Background The Chinese herbal Bufei Jianpi formula (BJF) provides an effective treatment option for chronic obstructive pulmonary disease (COPD). However, the systems-level mechanism underlying the clinical effects of BJF on COPD remains unknown. Methods In this study, a systems pharmacology model based on absorption filtering, network targeting, and systems analyses was applied specifically to clarify the active compounds and therapeutic mechanisms of BJF. Then, a rat model of cigarette smoke- and bacterial infection-induced COPD was used to investigate the therapeutic mechanisms of BJF on COPD and its comorbidity. Results The pharmacological system successfully identified 145 bioactive ingredients from BJF and revealed 175 potential targets. There was a significant target overlap between the herbal constituents of BJF. These results suggested that each herb of BJF connected with similar multitargets, indicating potential synergistic effects among them. The integrated target–disease network showed that BJF probably was efficient for the treatment of not only respiratory tract diseases but also other diseases, such as nervous system and cardiovascular diseases. The possible mechanisms of action of BJF were related to activation of inflammatory response, immune responses, and matrix metalloproteinases, among others. Furthermore, we demonstrated that BJF treatment could effectively prevent COPD and its comorbidities, such as ventricular hypertrophy, by inhibition of inflammatory cytokine production, matrix metalloproteinases expression, and other cytokine production in vivo. Conclusion This study using the systems pharmacology method, in combination with in vivo experiments, helped us successfully dissect the molecular mechanism of BJF for the treatment of COPD and predict the potential targets of the multicomponent BJF, which provides a new approach to illustrate the synergetic mechanism of the complex prescription and discover more effective drugs against COPD

  11. Effects of Chinese herbal medicine Yiqi Huaju Qingli Formula in metabolic syndrome patients with microalbuminuria: a randomized placebo-controlled trial

    Institute of Scientific and Technical Information of China (English)

    Tian-zhan Wang; Yu Chen; Yan-ming He; Xiao-dong Fu; Yi Wang; Yan-qiu Xu; Hong-jie Yang

    2013-01-01

    BACKGROUND:Microalbuminuria (MAU) is a key component of metabolic syndrome (MetS)and is an early sign of diabetic nephropathy as well.Although routine Western medicine treatments are given to MetS patients to control high blood pressure,hyperglycemia and dyslipidemia,some patients still experience progressive renal lesions and it is necessary to modify and improve the treatment strategy for MetS patients.OBJECTIVE:To investigate the efficacy of Yiqi Huaju Qingli Herb Formula,a compound traditional Chinese herbal medicine,in MetS patients with MAU when it is combined with routine Western medicine treatment.DESIGN,SETTING,PARTICIPANTS AND INTERVENTIONS:Sixty patients with MetS were randomized into the Chinese herbal formula group (CHF,Yiqi Huaju Qingli formula treatment in combination with Western medicine) and control group (placebo in combination with Western medicine).All treatments were administered for 12 weeks.MAIN OUTCOME MEASURES:Urinary microalbumin (MA),urinary albumin-to-creatinine ratio (UACR),24-hour total urine protein (24-hTP),body mass index (BMI),waist circumference (WC),waist-to-hip ratio (WHR),fasting plasma glucose (FPG),2-hour postprandial plasma glucose (2-hPPG),glycosylated hemoglobin (HbA1c),homeostasis model assessment for insulin resistance (HOMA-IR),blood lipid profile and blood pressure were observed.RESULTS:Compared with the control group,CHF treatment significantly decreased BMI (P<0.05),WC (P<0.01) and WHR (P<0.01).Both groups had significant decreases in FPG,2-hPPG,HbA1c,HOMA-IR,MA,and UACR,with CHF treatment showing better effects on these parameters compared with the control treatment (P<0.05).Both treatments significantly reduced the levels of total cholesterol,low-density lipoprotein cholesterol and triacylglycerol (TAG),and a greater reduction in TAG was observed with CHF treatment (P<0.05).The level of high-density lipoprotein cholesterol did not change in the control group after treatment (P>0.05),whereas it

  12. Suppression of Ongoing Experimental Arthritis by a Chinese Herbal Formula (Huo-Luo-Xiao-Ling Dan Involves Changes in Antigen-Induced Immunological and Biochemical Mediators of Inflammation

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    Ying-Hua Yang

    2011-01-01

    Full Text Available Rheumatoid arthritis (RA is one of the major autoimmune diseases of global prevalence. The use of the anti-inflammatory drugs for the treatment of RA is associated with severe adverse reactions and toxicity. This limitation has necessitated the search for novel therapeutic products. We report here a traditional Chinese medicine-based herbal formula, Huo luo xiao ling dan (HLXL, which has potent antiarthritic activity as validated in the rat adjuvant-induced arthritis (AA model. HLXL (2.3 g/Kg was fed to Lewis (RT.11 rats daily by gavage beginning at the onset of arthritis and then continued through the observation period. HLXL inhibited the severity of ongoing AA. This suppression of arthritis was associated with significant alterations in the T cell proliferative and cytokine responses as well as the antibody response against the disease-related antigen, mycobacterial heat-shock protein 65 (Bhsp65. There was a reduction in the level of the proinflammatory cytokines IL-17 and IL-1β but enhancement of the anti-inflammatory cytokine IL-10 level. In addition, there was inhibition of both the anti-Bhsp65 antibody response and the serum level of nitric oxide. Thus, HLXL is a promising CAM modality for further testing in RA patients.

  13. Chinese herbal formulaTongluo Jiunao injection protects against cerebral ischemia by activating neurotrophin 3/tropomyosin-related kinase C pathway

    Institute of Scientific and Technical Information of China (English)

    Peiman Alesheikh; Arezou Mashouif; Hui-ling Tang; Wei Zhang; Bo Di; Yang-yang Yan; Peng-tao Li; Yan-shu Pan

    2015-01-01

    The Chinese herbal formulaTongluo Jiunao, containing the active componentsPanax notogin-seng andGardenia jasminoides, has recently been patented and is in use clinically. It is known to be neuroprotective in cerebral ischemia, but the underlying pathway remains poorly understood. In the present study, we established a rat model of cerebral ischemia by occlusion of the middle cerebral artery, and administeredTongluo Jiunao, a positive control (Xuesai Tong, containing Panax notoginseng) or saline intraperitoneally to investigate the pathway involved in the action ofTongluo Jiunao injection. 2,3,5-Triphenyltetrazolium chloride (TTC) staining showed that the cerebral infarct area was signiifcantly smaller in model rats that receivedTongluo Jiunao than in those that received saline. Enzyme-linked immunosorbent assay revealed significantly greater expression of neurotrophin 3 and growth-associated protein 43 in ischemic cerebral tissue, and serum levels of neurotrophin 3, in theTongluo Jiunao group than in the saline group. The reverse transcription polymerase chain reaction and immunohistochemical staining showed that after treatment withTongluo Jiunao orXuesai Tong, tropomyosin-related kinase C gene expression and immunoreactivity were signiifcantly elevated compared with saline, with the greatest expression observed afterTongluo Jiunao treatment. These ifndings suggest thatTongluo Jiunao injection exerts a neuroprotective effect in rats with cerebral ischemia by activating the neurotrophin 3/tropomyosin-related kinase C pathway.

  14. JCM-16021, a Chinese Herbal Formula, Attenuated Visceral Hyperalgesia in TNBS-Induced Postinflammatory Irritable Bowel Syndrome through Reducing Colonic EC Cell Hyperplasia and Serotonin Availability in Rats.

    Science.gov (United States)

    Qin, Hong-Yan; Xiao, Hai-Tao; Leung, Fung-Ping; Yang, Zhi-Jun; Wu, Justin C Y; Sung, Joseph J Y; Xu, Hong-Xi; Tong, Xu-Dong; Bian, Zhao-Xiang

    2012-01-01

    The present study aimed to investigate the analgesic effect of JCM-16021, a revised traditional Chinese herbal formula, on postinflammatory irritable bowel syndrome (PI-IBS) in rats. The trinitrobenzene sulfonic (TNBS) acid-induced PI-IBS model rats were orally administrated with different doses of JCM-16021 (1.2, 2.4, and 4.8 g/kg/d) for 14 consecutive days. The results showed that JCM-16021 treatment dose-dependently attenuated visceral hyperalgesia in PI-IBS rats. Further, the colonic enterochromaffin (EC) cell number, serotonin (5-HT) content, tryptophan hydroxylase expression, and mechanical-stimuli-induced 5-HT release were significantly ameliorated. Moreover, the decreased levels of mucosal cytokines in PI-IBS, especially the helper T-cell type 1- (T(h)1-) related cytokine TNF-α, were also elevated after JCM-16021 treatment. These data demonstrate that the analgesic effect of JCM-16021 on TNBS-induced PI-IBS rats may be medicated via reducing colonic EC cell hyperplasia and 5-HT availability.

  15. JCM-16021, a Chinese Herbal Formula, Attenuated Visceral Hyperalgesia in TNBS-Induced Postinflammatory Irritable Bowel Syndrome through Reducing Colonic EC Cell Hyperplasia and Serotonin Availability in Rats

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    Hong-Yan Qin

    2012-01-01

    Full Text Available The present study aimed to investigate the analgesic effect of JCM-16021, a revised traditional Chinese herbal formula, on postinflammatory irritable bowel syndrome (PI-IBS in rats. The trinitrobenzene sulfonic (TNBS acid-induced PI-IBS model rats were orally administrated with different doses of JCM-16021 (1.2, 2.4, and 4.8 g/kg/d for 14 consecutive days. The results showed that JCM-16021 treatment dose-dependently attenuated visceral hyperalgesia in PI-IBS rats. Further, the colonic enterochromaffin (EC cell number, serotonin (5-HT content, tryptophan hydroxylase expression, and mechanical-stimuli-induced 5-HT release were significantly ameliorated. Moreover, the decreased levels of mucosal cytokines in PI-IBS, especially the helper T-cell type 1- (Th1- related cytokine TNF-α, were also elevated after JCM-16021 treatment. These data demonstrate that the analgesic effect of JCM-16021 on TNBS-induced PI-IBS rats may be medicated via reducing colonic EC cell hyperplasia and 5-HT availability.

  16. A yang-invigorating Chinese herbal formula enhances mitochondrial functional ability and antioxidant capacity in various tissues of male and female rats.

    Science.gov (United States)

    Leung, Hoi Yan; Chiu, Po Yee; Poon, Michel K T; Ko, Kam Ming

    2005-01-01

    The practice of traditional Chinese medicine (TCM) always emphasizes the prevention of diseases and delaying the onset of senility. In this regard, the maintenance of a balance of Yin and Yang-two opposing components involved in life activities as exemplified by the antagonistic action of the sympathetic and parasympathetic nervous systems-is essential in achieving a healthy condition. Previous studies have shown that long-term treatment with a Yang-invigorating Chinese herbal formula (VI-28) could increase red cell CuZn-superoxide dismutase (SOD) activity in male human subjects. In the present study, we examined the effects of chronic VI-28 treatment (80 and 240 mg/kg/day for 30 days) on red cell CuZn-SOD activity as well as mitochondrial functional ability and antioxidant components in various tissues of male and female rats. The results indicated that VI-28 treatment increased red cell CuZn-SOD activity as well as mitochondrial ATP generation capacity, reduced glutathione and alpha-tocopherol levels, and Mn-SOD activity in brain, heart, liver, and skeletal muscle tissues in both male and female rats to varying extents. The VI-28?induced increase in mitochondrial antioxidant capacity in various tissues was evidenced by the significant reduction in the extent of reactive oxygen species generation assessed by in vitro measurement. The red cell CuZn-SOD activities correlated positively with tissue mitochondrial antioxidant component levels/activity. The beneficial effect of VI-28 treatment on mitochondrial functional ability and antioxidant capacity may have clinical implications in the prevention of age-related diseases.

  17. Discovery of Anti-inflammatory Ingredients in Chinese Herbal Formula Kouyanqing Granule based on Relevance Analysis between Chemical Characters and Biological Effects.

    Science.gov (United States)

    Liu, Hong; Zheng, Yan-fang; Li, Chu-yuan; Zheng, Yu-ying; Wang, De-qin; Wu, Zhong; Huang, Lin; Wang, Yong-gang; Li, Pei-bo; Peng, Wei; Su, Wei-wei

    2015-12-10

    Kouyanqing Granule (KYQG) is a traditional Chinese herbal formula composed of Flos lonicerae (FL), Radix scrophulariae (RS), Radix ophiopogonis (RO), Radix asparagi (RA), and Radix et rhizoma glycyrrhizae (RG). In contrast with the typical method of separating and then biologicalily testing the components individually, this study was designed to establish an approach in order to define the core bioactive ingredients of the anti-inflammatory effects of KYQG based on the relevance analysis between chemical characters and biological effects. Eleven KYQG samples with different ingredients were prepared by changing the ratios of the 5 herbs. Thirty-eight ingredients in KYQG were identified using Ultra-fast liquid chromatography-Diode array detector-Quadrupole-Time-of-flight-Tandem mass spectrometry (UFLC-DAD-Q-TOF-MS/MS) technology. Human oral keratinocytes (HOK) were cultured for 24 hours with 5% of Cigarette smoke extract (CSE) to induce inflammation stress. Interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), and tumour necrosis factor-α (TNF-α) were evaluated after treatment with the eleven KYQG samples. Grey relational analysis(GRA), Pearson's correlations (PCC), and partial least-squares (PLS) were utilized to evaluate the contribution of each ingredient. The results indicated that KYQG significantly reduced interleukin-1β, interleukin-6, interleukin-8, and tumour necrosis factor-α levels, in which lysine, γ-aminobutyric acid, chelidonic acid, tyrosine, harpagide, neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, isoquercitrin, luteolin-7-o-glucoside, 3,4-dicaffeoylquinic acid, 3,5-dicaffeoylquinic acid, angoroside C, harpagoside, cinnamic acid, and ruscogenin play a vital role.

  18. Structural changes of gut microbiota in a rat non-alcoholic fatty liver disease model treated with a Chinese herbal formula.

    Science.gov (United States)

    Yin, Xiaochen; Peng, Jinghua; Zhao, Liping; Yu, Yunpeng; Zhang, Xu; Liu, Ping; Feng, Qin; Hu, Yiyang; Pang, Xiaoyan

    2013-05-01

    Accumulating evidence indicates that disruption of the gut microbiota by a high-fat diet (HFD) may play a pivotal role in the progression of metabolic disorders such as non-alcoholic fatty liver disease (NAFLD). In this study, the structural changes of gut microbiota were analyzed in an HFD-induced NAFLD rat model during treatment with an ancient Chinese herbal formula (CHF) used in clinical practice -Qushi Huayu Fang. CHF treatment significantly reduced body weight, alleviated hepatic steatosis, and decreased the content of triglycerides and free fatty acids in the livers of the rats. Gut microbiota of treated and control rats were profiled with polymerase chain reaction-denaturing gradient gel electrophoresis and bar-coded pyrosequencing of the V3 region of 16S rRNA genes. Both analyses indicated that the CHF-treated group harbored significantly different gut microbiota from that of model rats. Partial least squares discriminant analysis and taxonomy-based analysis were further employed to identify key phylotypes responding to HFD and CHF treatment. Most notably, the genera Escherichia/Shigella, containing opportunistic pathogens, were significantly enriched in HFD-fed rats compared to controls fed normal chow (P<0.05) but they decreased to control levels after CHF treatment. Collinsella, a genus with short chain fatty acid producers, was significantly elevated in CHF-treated rats compared to HFD-fed rats (P<0.05). The results revealed that the bacterial profiles of HFD-induced rats could be modulated by the CHF. Elucidation of these differences in microbiota composition provided a basis for further understanding the pharmacological mechanism of the CHF.

  19. The influence of traditional herbal formulas on cytokine activity.

    Science.gov (United States)

    Burns, J J; Zhao, Lijun; Taylor, Ethan Will; Spelman, Kevin

    2010-11-28

    Many of the botanical "immunomodulators", a class of herbal medicines widely recognized in traditional medical systems such as Chinese Medicine (TCM) and Ayurvedic Medicine, alter immune function and may offer clinically relevant therapeutics or leads to therapeutics. Many of these traditional remedies are prepared from combinations of medicinal plants which may influence numerous molecular pathways. These effects may differ from the sum of effects from the individual plants and therefore, research demonstrating the effects of the formula is crucial for insights into the effects of traditional remedies. In this review we surveyed the primary literature for research that focused on combinations of medicinal plants and effects on cytokine activity. The results demonstrate that many extracts of herb mixtures have effects on at least one cytokine. The most commonly studies cytokines were IL-4, IL-6, IL-10, TNF and IFN-γ. The majority of the formulas researched derived from TCM. The following formulas had activity on at least three cytokines; Chizukit N, CKBM, Daeganghwal-tang, Food Allergy Formula, Gamcho-Sasim-Tang, Hachimi-jio-gan, Herbkines, Hochuekki, Immune System Formula, Jeo-Dang-Tang, Juzen-taiho-to, Kakkon-to, Kan jang, Mao-Bushi-Saishin-to, MSSM-002, Ninjin-youei-to, PG201, Protec, Qing-huo-bai-du-yin, Qingfu Guanjieshu, Sambucol Active Defense, Seng-fu-tang, Shin-Xiao-Xiang, Tien Hsien, Thuja formula, Unkei-to, Vigconic, Wheeze-relief-formula, Xia-Bai-San, Yangyuk-Sanhwa-Tang, Yi-fey Ruenn-hou, and Yuldahansotang. Of the western based combinations, formulas with Echinacea spp. were common and showed multiple activities. Numerous formulas demonstrated activity on both gene and protein expression. The research demonstrates that the reviewed botanical formulas modulate cytokine activity, although the bulk of the research is in vitro. Therapeutic success using these formulas may be partially due to their effects on cytokines. Further study of phytotherapy on

  20. Tianjin Press of Chinese Herbal Medicines

    Institute of Scientific and Technical Information of China (English)

    2016-01-01

    Chinese Traditional and Herbal Drugs One of the most famous journals about Chinese herbal medicines in China.The journal started publication monthly since January 1970,is an academic and technical journal sponsored by Chinese Pharmaceutical Association and Tianjin Institute of Pharmaceutical Research.The journal which has a long history over 40 years offers the columns of

  1. Instruction to Authors of Chinese Herbal Medicines

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    @@ Chinese Herbal Medicines, an international journal sponsored by the Tianjin Institute of Pharmaceutical Research and Institute of Medicinal Plant Develop-ment. The Journal s purpose is to provide a forum for the studies on Chinese herbal medicines, traditional medicines, and natural products.

  2. Immunomodulatory Effect of Chinese Herbal Medicine Formula Sheng-Fei-Yu-Chuan-Tang in Lipopolysaccharide-Induced Acute Lung Injury Mice

    OpenAIRE

    Chia-Hung Lin; Ching-Hua Yeh; Li-Jen Lin; Shulhn-Der Wang; Jen-Shu Wang; Shung-Te Kao

    2013-01-01

    Traditional Chinese medicine formula Sheng-Fei-Yu-Chuan-Tang (SFYCT), consisting of 13 medicinal plants, was used to treat patients with lung diseases. This study investigated the immunoregulatory effect of SFYCT on intratracheal lipopolysaccharides- (LPS-) challenged acute lung injury (ALI) mice. SFYCT attenuated pulmonary edema, macrophages, and neutrophils infiltration in the airways. SFYCT decreased inflammatory cytokines, including tumor necrosis factor- α (TNF α ), interleukin-1 β , and...

  3. Quality Control Approaches for Chinese Herbal Medicines

    Institute of Scientific and Technical Information of China (English)

    YUAN Hai-long; ZHANG Tian-tian; XIAO Xiao-he

    2011-01-01

    The current official quality control approaches meet the challenges from the complexity of herbal medicines.In fact,any herbal medicines containing numerous unknown components,its curative effect usually depends on the whole of herbal medicines,so it is impossible and unnecessary to qualitatively and quantitatively study every component.By investigating the limitations of current quality control approaches for herbal medicines and the difference and similarity in the chemical substantial style as well as quality control pattern of herbal medicines,a new quality control approach for Chinese herbal medicines should be explored and designed.The combination approach of chemical analysis with bioassay is promising to be developed and employed in order to ensure the safety and efficacy of Chinese herbal medicines.

  4. Efficacy and Safety of a Traditional Chinese Herbal Formula Xuefu Zhuyu Decoction for Hypertension: A Systematic Review and Meta-Analysis.

    Science.gov (United States)

    Wang, Pengqian; Xiong, Xingjiang; Li, Shengjie

    2015-10-01

    The cardioprotective role of xuefu zhuyu decoction (XZD), a well-known classical herbal formula, has been documented for hypertension treatment recently. This study aims to summarize the efficacy and safety of XZD in treating hypertension.Seven databases were searched to identify randomized controlled trials evaluating the efficacy of XZD in hypertensive patients. Fifteen studies involving 1364 hypertensive patients were included. All studies compared XZD and antihypertensive drugs with antihypertensive drugs used alone.In all, 15 studies reported significant effects of XZD for lowering blood pressure compared with the control group (P drugs in improving total cholesterol, triglycerides, low-density lipoprotein cholesterol, homocysteine, hemorheology, carotid intima-media thickness, and left ventricular mass index (P hypertension. Although concerns regarding selective bias and methodologic flaws were raised, our findings suggests XZD as a new candidate cardioprotective drug for hypertension, which should be given priority for future preclinical and clinical studies.

  5. Combining systems pharmacology, transcriptomics, proteomics, and metabolomics to dissect the therapeutic mechanism of Chinese herbal Bufei Jianpi formula for application to COPD

    Directory of Open Access Journals (Sweden)

    Zhao P

    2016-03-01

    Full Text Available Peng Zhao,1,2 Liping Yang,1,2 Jiansheng Li,1,2 Ya Li,1,2 Yange Tian,1,2 Suyun Li2,3 1Key Laboratory of Chinese Internal Medicine, Henan University of Traditional Chinese Medicine, 2Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment and Chinese Medicine Development of Henan Province, 3Department of Respiratory Diseases, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, People’s Republic of China Abstract: Bufei Jianpi formula (BJF has long been used as a therapeutic agent in the treatment of COPD. Systems pharmacology identified 145 active compounds and 175 potential targets of BJF in a previous study. Additionally, BJF was previously shown to effectively prevent COPD and its comorbidities, such as ventricular hypertrophy, by inhibition of inflammatory cytokine production, matrix metalloproteinases expression, and other cytokine production, in vivo. However, the system-level mechanism of BJF for the treatment of COPD is still unclear. The aim of this study was to gain insight into its system-level mechanisms by integrating transcriptomics, proteomics, and metabolomics together with systems pharmacology datasets. Using molecular function, pathway, and network analyses, the genes and proteins regulated in COPD rats and BJF-treated rats could be mainly attributed to oxidoreductase activity, antioxidant activity, focal adhesion, tight junction, or adherens junction. Furthermore, a comprehensive analysis of systems pharmacology, transcript, protein, and metabolite datasets is performed. The results showed that a number of genes, proteins, metabolites regulated in BJF-treated rats and potential target proteins of BJF were involved in lipid metabolism, cell junction, oxidative stress, and inflammatory response, which might be the system-level therapeutic mechanism of BJF treatment. Keywords: Bufei Jianpi formula, system-level therapeutic mechanism, transcriptomic, proteomic

  6. Antioxidant and Antiadipogenic Activities of Galkeun-Tang, a Traditional Korean Herbal Formula

    OpenAIRE

    2014-01-01

    Galkeun-tang (GKT; Galgen-tang in Chinese and Kakkon-to in Japanese), a traditional herbal formula, has been used for treatment of the common cold. Here, we report in vitro antioxidant and antiadipogenic effects of GKT. GKT increased the activities of scavenging 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals. GKT also significantly reduced the malondialdehyde (MDA) generation during low-density lipoprotein (LDL) oxidation and th...

  7. Effective Components of Chinese Herbal Compound Decoction and Maillard Reaction

    Institute of Scientific and Technical Information of China (English)

    曹治云; 陈旭征; 张恩达; 杜建

    2009-01-01

    This paper intends to explore the color changes considered to be Maillard reaction during the process of Chinese herbal medicine.The Maillard reaction products(MRPs) are often in substantial proportions of Chinese herbal compound decoctions but their effects are often neglected.By considering the effects of MRPs in studies of effective components on Chinese herbal compounds,a new perspective is established in future researches of Chinese herbal compound decoctions.

  8. Tianjin Press of Chinese Herbal Medicines

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

    <正>Chinese Traditional and Herbal Drugs The journal started publication monthly since January 1970, is an academic and technical journal sponsored by Chinese Pharmaceutical Association and Tianjin Institute of Pharmaceutical Research. The journal which has a long history over 40 years offers the columns of research papers, brief reports, reviews, dissertation, and special treatises to report the recent achievements of the basic study, production, quality

  9. Latest Progress on Chinese Herbal Medicines

    Institute of Scientific and Technical Information of China (English)

    Tianjin Press of Chinese Herbal Medicines

    2010-01-01

    @@ Chinese Herbal Medicines (CHM) has been recently included in the Wanfang Database-Digital Periodical Group, China Academic Journals Integrated Online Database, Index of Copernicus (IC) in Poland, Chemical Abstracts Service (CAS) in USA, and Ulrich's Periodicals Directory domestically and abroad.

  10. Systematic chemical profiling of a multicomponent Chinese herbal formula Huo Luo Xiao Ling Dan by ultra high performance liquid chromatography coupled with electrospray ionization quadrupoletime-of-flight mass spectrometry.

    Science.gov (United States)

    Wang, Fenrong; Ai, Yu; Wu, Yun; Ma, Wen; Bian, Qiaoxia; Lee, David Y-W; Dai, Ronghua

    2015-03-01

    Huo Luo Xiao Ling Dan, a Chinese herbal formula consisting of 11 different herbs, has been used in folk medicine for the treatment of arthritis and other chronic inflammatory diseases. However, the chemical compositions of Huo Luo Xiao Ling Dan are not completely characterized. In the present study, an ultra high performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry method in positive and negative ion modes was employed to identify biochemical constitutes in Huo Luo Xiao Ling Dan. As a result, a total of 76 compounds including alkaloids, monoterpene glycosides, iridoids, phenolic acids, and tanshinones, coumarins, lactones, flavones, and their glycosides, triterpenes, and triterpene saponins were characterized by comparing the retention time and mass spectrometry data with reference standards within 5 ppm error or by reference to the reference literature. These results would provide the basis for a further in vivo study of Huo Luo Xiao Ling Dan and information for potential new drug candidates for treating arthritis and other chronic inflammatory diseases.

  11. An Integrative Platform of TCM Network Pharmacology and Its Application on a Herbal Formula, Qing-Luo-Yin

    Directory of Open Access Journals (Sweden)

    Bo Zhang

    2013-01-01

    Full Text Available The scientific understanding of traditional Chinese medicine (TCM has been hindered by the lack of methods that can explore the complex nature and combinatorial rules of herbal formulae. On the assumption that herbal ingredients mainly target a molecular network to adjust the imbalance of human body, here we present a-self-developed TCM network pharmacology platform for discovering herbal formulae in a systematic manner. This platform integrates a set of network-based methods that we established previously to catch the network regulation mechanism and to identify active ingredients as well as synergistic combinations for a given herbal formula. We then provided a case study on an antirheumatoid arthritis (RA formula, Qing-Luo-Yin (QLY, to demonstrate the usability of the platform. We revealed the target network of QLY against RA-related key processes including angiogenesis, inflammatory response, and immune response, based on which we not only predicted active and synergistic ingredients from QLY but also interpreted the combinatorial rule of this formula. These findings are either verified by the literature evidence or have the potential to guide further experiments. Therefore, such a network pharmacology strategy and platform is expected to make the systematical study of herbal formulae achievable and to make the TCM drug discovery predictable.

  12. Analysis of active patents to investigate the frequency and patterns of Chinese herbal extract combinations claiming to treat heart disease

    Directory of Open Access Journals (Sweden)

    Jiangxue Cheng

    2016-04-01

    Conclusion: Most of the high-frequency Chinese herbs in the patents investigated belong to the high-frequency herbal families, and herb pairs were commonly selected to coincide with the commonly-used herbal family pairs. Low-frequency Chinese herbs were also used, but generally belonged to the high-frequency herbal families, and were therefore similar to the high-frequency herbs in terms of traditional categories of taste and channel entered. The results reflect the use of traditional principles of formula composition, and suggest that these principles may indeed be an effective guide for further research and development of Chinese herbal extract combinations to prevent and treat heart diseases.

  13. Preface for the First Issue of Chinese Herbal Medicines

    Institute of Scientific and Technical Information of China (English)

    肖培根

    2009-01-01

    With more than 5000 years of Chinese history and as a part of Chinese culture, Chinese herbal medicines have been playing a critical role in fighting various diseases and keeping human’s health. More than 5000 Chinese herbal medicines collected in the Comprehensive

  14. Latest Progress in Tianjin Press of Chinese Herbal Medicines

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

    <正>Four journals including Chinese Traditional and Herbal Drugs (CTHD), Chinese Herbal Medicines (CHM), Drugs & Clinic (DC), and Drug Evaluation Research (DER) are edited and published by Tianjin Press of Chinese Herbal Medicines. CTHD was first published in 1970 and has been playing a great role for Chinese materia medica (CMM), especially in its present modernization. CTHD has successively won several honors in recent years, such as the 2nd State

  15. [A complexity analysis of Chinese herbal property theory: the multiple expressions of herbal property].

    Science.gov (United States)

    Jin, Rui; Zhang, Bing

    2012-12-01

    Chinese herbal property is the highly summarized concept of herbal nature and pharmaceutical effect, which reflect the characteristics of herbal actions on human body. These herbal actions, also interpreted as presenting the information about pharmaceutical effect contained in herbal property on the biological carrier, are defined as herbal property expressions. However, the biological expression of herbal property is believed to possess complex features for the involved complexity of Chinese medicine and organism. Firstly, there are multiple factors which could influence the expression results of herbal property such as the growth environment, harvest season and preparing methods of medicinal herbs, and physique and syndrome of body. Secondly, there are multiple biological approaches and biochemical indicators for the expression of the same property. This paper elaborated these complexities for further understanding of herbal property. The individuality of herbs and expression factors should be well analyzed in the related studies.

  16. Tong-xie-ning, a Chinese herbal formula, in treatment of diarrhea-predominant irritable bowel syndrome: a prospective,randomized, double-blind, placebo-controlled trial

    Institute of Scientific and Technical Information of China (English)

    WANG Gang; HUANG Xi; ZHANG Rui-ming; LI Ting-qian; WANG Lei; XIA Qing; CHANG Jing; ZHANG Ying; WAN Mei-hua; GUO Jia; CHENG Yan

    2006-01-01

    @@ Currently the main components of treatment for irritable bowel syndrome (IBS) include patient education and reassurance, dietary modification,symptomatic treatment, and psychological treatment,but little evidence exists that the current pharmaceutical agents routinely used in treating IBS patients are efficacious.1 Partly from lack of effective conventional therapeutics and in search of better treatment options, many patients with IBS in both the east and west have turned to complementary and alternative approaches, including traditional Chinese medicine (TCM).2,3

  17. Ultra high performance liquid chromatography with tandem mass spectrometry for rapid separation and identification of main constituents in Chinese herbal formula Xuan Hu Suo San.

    Science.gov (United States)

    Tang, Huaqi; Zhang, Xinyue; Luo, Shilin; Shang, Fei; Chen, Jianping; Wang, Jinghong; Duan, Xiaojie; Gao, Xiaoyan; Sun, Yikun

    2017-02-15

    Xuan Hu Suo San (XHSS) is a traditional Chinese medicine that has been extensively applied in the treatment of osteoarthritis for many years, however, its chemical composition has not yet been elucidated. Thus, a rapid, efficient, and precise method based on ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry was applied in both positive- and negative-ion modes to rapidly separate and identify the main chemical ingredients in XHSS for the first time. Finally, with the optimised separation and detection method, a total of 57 compounds were simultaneously separated within 13 min, among which 14 compounds were confirmed by comparing retention time and MS data with reference standards and others were tentatively identified by comparing with reference literatures. This rapid and sensitive approach is highly useful for the identification and characterisation of chemical constituents, and provides fundamental and extensive information supporting further metabolic and pharmacokinetic studies of XHSS.

  18. Combining systems pharmacology, transcriptomics, proteomics, and metabolomics to dissect the therapeutic mechanism of Chinese herbal Bufei Jianpi formula for application to COPD

    Science.gov (United States)

    Zhao, Peng; Yang, Liping; Li, Jiansheng; Li, Ya; Tian, Yange; Li, Suyun

    2016-01-01

    Bufei Jianpi formula (BJF) has long been used as a therapeutic agent in the treatment of COPD. Systems pharmacology identified 145 active compounds and 175 potential targets of BJF in a previous study. Additionally, BJF was previously shown to effectively prevent COPD and its comorbidities, such as ventricular hypertrophy, by inhibition of inflammatory cytokine production, matrix metalloproteinases expression, and other cytokine production, in vivo. However, the system-level mechanism of BJF for the treatment of COPD is still unclear. The aim of this study was to gain insight into its system-level mechanisms by integrating transcriptomics, proteomics, and metabolomics together with systems pharmacology datasets. Using molecular function, pathway, and network analyses, the genes and proteins regulated in COPD rats and BJF-treated rats could be mainly attributed to oxidoreductase activity, antioxidant activity, focal adhesion, tight junction, or adherens junction. Furthermore, a comprehensive analysis of systems pharmacology, transcript, protein, and metabolite datasets is performed. The results showed that a number of genes, proteins, metabolites regulated in BJF-treated rats and potential target proteins of BJF were involved in lipid metabolism, cell junction, oxidative stress, and inflammatory response, which might be the system-level therapeutic mechanism of BJF treatment. PMID:27042044

  19. Chinese herbal medicine research in eczema treatment

    Directory of Open Access Journals (Sweden)

    Leung Ping

    2011-04-01

    Full Text Available Abstract Eczema is a chronic relapsing atopic dermatitis (AD associated with pruritus, sleep disturbance and poor quality of life of the patient. Treatment of eczema includes use of emollient, topical and systemic antimicrobial agents, corticosteroid or immunomodulating agents. Many patients also seek alternative treatments such as dietary avoidance, supplementation or both. This article reviews the basic pathophysiology of eczema and clinical trials involving Chinese medicine in the treatment of eczema. Research reports on Chinese herbal medicine for eczema were retrieved from PubMed and the Cochrane Database for Systematic Reviews for this review. Only a few RCTs demonstrated the efficacy (or lack of efficacy of Chinese medicinal herbs in treating atopic eczema. Further larger scale trials are warranted.

  20. Chinese herbal medicine for severe acute respiratory syndrome

    DEFF Research Database (Denmark)

    Liu, Jianping; Manheimer, Eric; Shi, Yi

    2004-01-01

    To review randomized controlled trials (RCTs) evaluating the effects of Chinese herbal medicine for treating severe acute respiratory syndrome (SARS) systematically.......To review randomized controlled trials (RCTs) evaluating the effects of Chinese herbal medicine for treating severe acute respiratory syndrome (SARS) systematically....

  1. Studies on Treating Eczema by Chinese Herbal Medicine with Anti-Type Ⅳ Allergic Activity

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Objective: To study Chinese herbal prescription for treatment of eczema on the basis of the suppressive effect of Chinese herbal medicine with type Ⅳ allergic reaction. Methods: Various formulae composed of Chinese herbal medicines possessing suppressive effect on murine allergic contact dermatitis were formed following the therapeutic principles of traditional Chinese medicine in treating eczema, and their effect on ear swelling, ear flake weight, dermal inflammatory infiltration cell count and plasma level of calcitonin gene related peptide ( CGRP) were examined in mice with dinitrofluorobenzene induced dermatitis. The prescription, Composite Poria Decoction was formulated and made into granule form, which was used to treat 63 cases of eczema (atopic dermatitis was excluded), and compared with 59 cases treated with antihistaminic that was aimed at the type I allergic reaction. Results: Experimental study showed that all the 4 Chinese prescriptions had the effect of anti-type Ⅳ allergic reaction, among them, the formula for cooling blood and removing Heat, Wind and Dampness evil possessed the most potent effect in suppressing murine dermatitis, and it was also able to up-regulate the plasma CGRP concentration. The clinical cure rate of Composite Poria Granule treatment was 47.6%, and that of the control was 22.0%. The difference was significant between the two groups (u=2.9555, P<0.01). Conclusions: Chinese herbal medicine has the effect of anti-type Ⅳ allergic reaction. Composite Poria Granule has good effect in treating eczema.

  2. Safety and efficacy assessment of standardized herbal formula PM012

    Directory of Open Access Journals (Sweden)

    Sohn Sung-Hwa

    2012-03-01

    Full Text Available Abstract Background This study was conducted to evaluate the efficacy of the herbal formula PM012 on an Alzheimer's disease model, human presenilin 2 mutant transgenic mice (hPS2m, and also to evaluate the toxicity of PM012 in Sprague-Dawely rats after 4 or 26 weeks treatment with repeated oral administration. Methods Spatial learning and memory capacities of hPS2m transgenic mice were evaluated using the Morris Water Maze. Simultaneously, PM012 was repeatedly administered orally to male and female SD rats (15/sex/group at doses of 0 (vehicle control, 500, 1,000 and 2,000 mg/kg/day for 4 or 26 weeks. To evaluate the recovery potential, 5 animals of each sex were assigned to vehicle control and 2,000 mg/kg/day groups during the 4-week recovery period. Results The results showed that PM012-treated hPS2m transgenic mice showed significantly reduced escape latency when compared with the hPS2m transgenic mice. The repeated oral administration of PM012 over 26 weeks in male and female rats induced an increase and increasing trend in thymus weight in the female treatment groups (main and recovery groups, but the change was judged to be toxicologically insignificant. In addition, the oral administration of the herbal medicine PM012 did not cause adverse effects as assessed by clinical signs, mortality, body weight, food and water consumption, ophthalmology, urinalysis, hematology, serum biochemistry, blood clotting time, organ weights and histopathology. The No Observed Adverse Effects Levels of PM012 was determined to be 2,000 mg/kg/day for both sexes, and the target organ was not identified. Conclusion These results suggest that PM012 has potential for use in the treatment of the Alzheimer's disease without serious adverse effects.

  3. Safety concerns of herbal products and traditional Chinese herbal medicines: Dehydropyrrolizidine alkaloids and aristolochic acid

    Science.gov (United States)

    In many countries, including the United States, herbal supplements, tisanes and vegetable products, including traditional Chinese medicines, are largely unregulated and their content is not registered, monitored or verified. Consequently, potent plant toxins including dehydropyrrolizidine alkaloids ...

  4. Safety concerns of herbal products and traditional Chinese herbal medicines: Dehydopyrrolizidine alkaloids and aristolochic acid

    Science.gov (United States)

    In many countries, including the United States, herbal supplements, tisanes and vegetable products including traditional Chinese medicines are largely unregulated and their content is not registered, monitored or verified. Consequently potent plant toxins including dehydopyrrolizidine alkaloids and...

  5. Antioxidant and antiadipogenic activities of galkeun-tang, a traditional korean herbal formula.

    Science.gov (United States)

    Jeong, Soo-Jin; Yoo, Sae-Rom; Kim, Ohn-Soon; Seo, Chang-Seob; Shin, Hyeun-Kyoo

    2014-01-01

    Galkeun-tang (GKT; Galgen-tang in Chinese and Kakkon-to in Japanese), a traditional herbal formula, has been used for treatment of the common cold. Here, we report in vitro antioxidant and antiadipogenic effects of GKT. GKT increased the activities of scavenging 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals. GKT also significantly reduced the malondialdehyde (MDA) generation during low-density lipoprotein (LDL) oxidation and the electrophoretic mobility of oxidized LDL, indicating inhibitory effects of GKT on Cu(2+)-mediated oxidation of LDL. Regarding antiadipogenic activity, GKT treatment significantly suppressed lipid accumulation, triglyceride production, and glycerol-3-phosphate dehydrogenase (GPDH) activity in differentiated 3T3-L1 adipocytes. Consistent with this, GKT significantly reduced the secretion of leptin, a major adipokine, in differentiated 3T3-L1 adipocytes. Overall, our findings suggest that GKT has the potential for antioxidative and antiadipogenic properties.

  6. Evaluation of herbal formulas by pulse analysis method%以脉波分析法评价中草药方

    Institute of Scientific and Technical Information of China (English)

    王唯工; 徐则林; 鲍建国; 王林玉英

    2003-01-01

    AIM: To distinguish the component difference between two similar herbal formulas by pulse analysis method.Many Chinese herbs were found to have specific effects on the Fourier components of the blood pressure pulse; itmight infer a specific blood redistribution process on the body and reflect the health conditions of specific organsor tissues. The pulse effect of an herbal formula was similar to the linear combination of all its herbal compositions.METHODS: Two different versions of the herbal formula Liu-Wei-Dihuang were fed to the Wistar rats as a singleblind test. The blood pressure pulses on the rat tail artery were recorded and then transformed to the frequencydomain by Fourier analyzer. RESULTS: Formula A, Bai-Wei-Dihuang, with two more herbs Cortex Cinnamomiand Radix Aconiti added to Liu-Wei-Dihuang, increased the harmonic proportion of the 1st harmonic (C1) butdecreased C4, C5. Formula B is composed in the same way but without Rhizoma Batatatis and Poria cocos; itincreased the DC of the pulse spectrum (CO), but decreased C2, C3, C4, C5, C6. CONCLUSION: The componentadjustment of an herbal formula could be distinctly and quantitatively detected by pulse analysis method.

  7. Prescription of Chinese Herbal Medicine in Pattern-Based Traditional Chinese Medicine Treatment for Depression: A Systematic Review

    Directory of Open Access Journals (Sweden)

    Wing-Fai Yeung

    2015-01-01

    Full Text Available Traditional Chinese medicine (TCM treatments are often prescribed based on individuals’ pattern diagnoses. A systematic review of randomized controlled trials in Chinese and English literatures on TCM pattern-based treatment for depression has therefore been conducted. A total of 61 studies, 2504 subjects, and 27 TCM patterns were included. Due to the large variation of TCM pattern among participants, we only analyzed the top four commonly studied TCM patterns: liver qi depression, liver depression and spleen deficiency, dual deficiency of the heart, and spleen and liver depression and qi stagnation. We found that Xiaoyao decoction was the most frequently used herbal formula for the treatment of liver qi depression and liver depression with spleen deficiency, while Chaihu Shugan decoction was often used for liver depression and qi stagnation. Bai Shao (Paeonia lactiflora Pall. and Chai Hu (Bupleurum chinense DC. were commonly used across different TCM patterns regardless of the prescribed Chinese herbal formulas. The rationale underlying herb selection was seldom provided. Due to the limited number of studies on TCM pattern-based treatment of depression and their low methodological quality, we are unable to draw any conclusion regarding which herbal formulas have higher efficacy and which TCM patterns respond better to CHM.

  8. Tonic Herbs and Herbal Mixtures in Chinese Medicine

    Directory of Open Access Journals (Sweden)

    Thomas Efferth

    2016-01-01

    Full Text Available This review results from a PubMed-based data-mining of scientific literature concerning typical tonic herbs and formulas of Chinese herbal medicine and their application principle under the theory of CM. We have focused on two aspects of tonic activity: body tonification against qi气-, blood血-, yin阴- and yang阳-deficiency, respectively, and organ (Zang 脏and Fu腑 tonification against heart-, liver-, spleen/stomach-, lung-, and kidney-deficiency, respectively. Body-tonifying herbs are: Astragalus Membranaceus Radix (Huang-qi黄芪 and Panax Ginseng Radix (Ren-shen人参 for qi-tonification; Angelicae Sinensis Radix (Dang-gui当归 and Rehmannia Glutinosa Radix Preparata (Shu-di熟地 for blood-tonification; Ophiopogon Japonicus Radix (Mai-dong麦冬 and Scrophularia Ningpoensis Radix (Xuan-shen玄参 for yin-deficiency; Myristica Fragrans Semen (Rou-dou-kou肉豆蔻 and Psoralea Corylifolia Fructus (Bu-gu-zhi补骨脂 for yang-deficiency. The corresponding CM formulas are: Bu-zhong-yi-qi decoction (补中益气汤 for qi-tonification; Si-wu decoction (四物汤 for blood-tonification; Zeng-ye decoction (增液汤 for yin-tonification; Si-shen pill (四神丸 for yang-tonification. Organ-tonifying herbs are: Glycyrrhizae Uralensis Radix Preparata (Zhi-gan-cao炙甘草 and Rehmannia Glutinosa Radix (Di-huang地黄 for heart-tonification; Lycium Barbarum Fructus (Gou-qi-zi枸杞子 and Angelicae Sinensis Radix (Dang-gui当归 for liver-tonification; Panax Ginseng Radix (Ren-shen人参 and Atractylodis Macrocephala Rhizoma (Bai-zhu白术 for spleen/stomach-tonification; Panax Ginseng Radix (Ren-shen人参 and Astragalus Membranaceus Radix (Huang-qi黄芪 for lung-tonification; Cornus Officinalis Fructus (Shan-zhu-yu山茱萸 and Dioscorea Opposite Rhizoma (Shan-yao山药 for kidney-tonification. The corresponding CM formulas are: Zhi-gan-cao decoction (炙甘草汤 for heart-tonification; Yi-guan decoction (一贯煎 for liver

  9. [A complexity analysis of Chinese herbal property theory: the multiple formations of herbal property].

    Science.gov (United States)

    Jin, Rui; Zhang, Bing

    2012-11-01

    Chinese herbal property theory (CHPT) is the fundamental characteristic of Chinese materia medica different from modern medicines. It reflects the herbal properties associated with efficacy and formed the early framework of four properties and five flavors in Shennong's Classic of Materia Medica. After the supplement and improvement of CHPT in the past thousands of years, it has developed a theory system including four properties, five flavors, meridian entry, direction of medicinal actions (ascending, descending, floating and sinking) and toxicity. However, because of the influence of philosophy about yin-yang theory and five-phase theory and the difference of cognitive approach and historical background at different times, CHPT became complex. One of the complexity features was the multiple methods for determining herbal property, which might include the inference from herbal efficacy, the thought of Chinese Taoist School and witchcraft, the classification thinking according to manifestations, etc. Another complexity feature was the multiselection associations between herbal property and efficacy, which indicated that the same property could be inferred from different kinds of efficacy. This paper analyzed these complexity features and provided the importance of cognitive approaches and efficacy attributes corresponding to certain herbal property in the study of CHPT.

  10. Long-term dietary supplementation with a yang-invigorating Chinese herbal formula increases lifespan and mitigates age-associated declines in mitochondrial antioxidant status and functional ability of various tissues in male and female C57BL/6J mice.

    Science.gov (United States)

    Ko, Kam Ming; Chiu, Po Yee; Leung, Hoi Yan; Siu, Ada Hoi Ling; Chen, Na; Leong, Eriol Pou Kwan; Poon, Michel K T

    2010-01-01

    To investigate whether Vigconic 28 (VI-28), a Yang-invigorating Chinese herbal formula, could affect survival of aging animals, male and female C57BL/6J mice were given a VI-28-supplemented diet (0.05 and 0.5%, wt/wt) starting at 36 weeks of age, until death. VI-28 dietary supplementation at 0.05% significantly increased median lifespans of both male and female mice as compared to controls. Survival enhancement was associated with protection against age-associated impairments in mitochondrial antioxidant status and functional ability in various tissues. In conclusion, VI-28 could retard the aging process in mice, probably by mitigating age-associated declines in mitochondrial antioxidant status and functional ability in tissues.

  11. Chinese Herbal Medicine for Symptom Management in Cancer Palliative Care

    OpenAIRE

    2016-01-01

    Abstract Use of Chinese herbal medicines (CHM) in symptom management for cancer palliative care is very common in Chinese populations but clinical evidence on their effectiveness is yet to be synthesized. To conduct a systematic review with meta-analysis to summarize results from CHM randomized controlled trials (RCTs) focusing on symptoms that are undertreated in conventional cancer palliative care. Five international and 3 Chinese databases were searched. RCTs evaluating CHM, either in comb...

  12. The use of Chinese herbal drugs in Islamic medicine

    Institute of Scientific and Technical Information of China (English)

    Mojtaba Heyadri; Mohammad Hashem Hashempur; Mohammad Hosein Ayati; Detlev Quintern; Majid Nimrouzi; Seyed Hamdollah Mosavat

    2015-01-01

    This paper investigates some of the ways that Chinese medicine has been transferred to the Western world and to Islamic territories. During the Golden Age of Islam (8th to 13th century CE), the herbal drug trade promoted significant commercial and scientific exchange between China and the Muslim world. Chinese herbal drugs have been described by medieval Muslim medical scholars such as Tabari (870 CE), Rhazes (925 CE), Haly Abbas (982 CE), Avicenna (1037 CE) and Jurjani (1137 CE). The term al-sin (the Arabic word for China) is used 46 times in Avicenna’s Canon of Medicine in reference to herbal drugs imported from China. Cinnamon (dar sini; “Chinese herb”), wild ginger (asaron), rhubarb (rivand-e sini), nutmeg (basbasa), incense tree wood (ood), cubeb (kababe) and sandalwood (sandal) were the most frequently mentioned Chinese herbs in Islamic medical books. There are also multiple similarities between the clinical uses of these herbs in both medical systems. It appears that Chinese herbal drugs were a major component of the exchange of goods and knowledge between China and the Islamic and later to the Western world amid this era.

  13. Global Expansion Strategy of Chinese Herbal Tea Beverage

    Directory of Open Access Journals (Sweden)

    Yong Liu

    2015-03-01

    Full Text Available In order to provide insights into the potential future of Chinese herbal tea beverage industry, we analyze serious challenge on how the herbal tea beverage will develop global expansion strategy in china, as well as a series of recommendations as to how the sector might collaborate and respond. This study discusses the key challenges and opportunities factors that Chinese traditional tea industry face, from across the global value chain, representing both producer and consumer countries and including topics ranging from climate change to finance and markets. For these ever-growing problems, factors as diverse as the use of precision farming, biodiversity, production instability and consumer demand for personalization of products were identified. To support the development of Chinese traditional tea industry, increase investment, vigorously promote to transfer Chinese traditional tea into fast, convenient, standardized and normalized tea beverage products for global expansion strategy of Chinese herbal tea beverage, so as to promote the development of Chinese traditional tea industry and make the regional contribution to the realization of Chinese dream.

  14. Identifying Core Herbal Treatments for Children with Asthma: Implication from a Chinese Herbal Medicine Database in Taiwan

    Directory of Open Access Journals (Sweden)

    Hsing-Yu Chen

    2013-01-01

    Full Text Available Asthma is one of the most common allergic respiratory diseases around the world and places great burden on medical payment. Chinese herbal medicine (CHM is commonly used for Taiwanese children to control diseases. The aim of this study is to analyze the CHM prescriptions for asthmatic children by using a nationwide clinical database. The National Health Insurance Research Database (NHIRD was used to perform this study. Medical records from 1997 to 2009 with diagnosis with asthma made for children aged 6 to 18 were included into the analysis. Association rule mining and social network analysis were used to analyze the prevalence of single CHM and its combinations. Ma-Xing-Gan-Shi-Tang (MXGST was the most commonly used herbal formula (HF (20.2% of all prescriptions, followed by Xiao-Qing-Long-Tang (13.1% and Xing-Su-San (12.8%. Zhe Bei Mu is the most frequently used single herb (SH (14.6%, followed by Xing Ren (10.7%. MXGST was commonly used with Zhe Bei Mu (3.5% and other single herbs capable of dispelling phlegm. Besides, MXGST was the core formula to relieve asthma. Further studies about efficacy and drug safety are needed for the CHM commonly used for asthma based on the result of this study.

  15. Delayed luminescence: an experimental protocol for Chinese herbal medicines

    NARCIS (Netherlands)

    Sun, M.; Wijk, R. van; Wijk, E. van; Wang, M.; Wietmarschen, H. van; Hankemeier, T.; Greef, J. van der

    2016-01-01

    In Chinese medicine, raw herbal materials are used in processed and unprocessed forms aiming to meet the different requirements of clinical practice. To assure the chemical quality and therapeutic properties of the herbs, fast and integrated systematic assays are required. So far, such assays have n

  16. In vivo screening for anti-osteoporotic fraction from extract of herbal formula Xianlinggubao in ovariectomized mice.

    Directory of Open Access Journals (Sweden)

    Xinluan Wang

    Full Text Available Traditional Chinese Medicine (TCM Fufang or formula Xianlinggubao (XLGB is a prescribed TCM drug in China registered for prevention and treatment of osteoporosis. Fufang in TCM is comprised of a group of herbal compounds contributing in group to the treatment efficacy. The present study aims to identify the bioactive fraction(s in XLGB extract that account(s dominantly for its osteogenic effects.The extract of XLGB formula was separated into three fractions using chromatography, i.e., XLGB-A, XLGB-B and XLGB-C. They were administrated to 4-month old ovariectomized (OVX mice for 6 weeks to determine which bioactive fraction(s were more effective for preventing OVX-induced bone loss evaluated by microCT, biomechanical testing and biochemical markers. The main peaks of the key fraction were identified using reference compounds isolated from the fraction. In addition, the effects of the composite compounds in XLGB-B on osteoblasts' proliferation and mineralization were evaluated in UMR 106 cells.XLGB-B with a yield of 13.0% from herbal Fufang XLGB was identified as the most potential one among the three fractions for prevention of OVX-induced bone loss confirmed with bone mass, bone microarchitecture, bone strength and bone turnover markers. Nine compounds in HPLC fingerprint were identified in the XLGB-B fraction, including phenylpropanoids from Herba Epimedii, terpenes from Radix Dipsaci and coumarins from Fructus Psoraleae. In addition, the identified compounds effectively promoted proliferation and/or mineralization of osteoblast-like UMR 106 cells in vitro.XLGB-B with defined phytochemical structures was screened as the key fraction that demonstrated preventive effects on OVX-induced bone loss in mice. The present study laid down a foundation towards a new generation of herbal Fufang characterized with "less herbal materials for achieving equal treatment efficacy" in development strategy of TCM for prevention of OVX-induced osteoporosis.

  17. Toxicological study of the hepatotherapeutic herbal formula, Chunggan extract, in beagle dogs

    Institute of Scientific and Technical Information of China (English)

    Woo-Jin Choi; Hwa-Seung Yoo; Yeon-Weol Lee; Chang-Gue Son; Jang-Woo Shin; Jin-Young Son; Dong-Seok Seo; Hark-Soo Park; Seung-Hyun Han; Ha-Jung Sung; Jung-Hyo Cho; Chong-Kwan Cho

    2006-01-01

    AIM: To evaluate the pharmaceutical safety of a Chinese herbal formula, Chunggan extract (CGX), traditionally prescribed as a hepatotherapeutic drug via systemic acute and subacute toxicological study.METHODS: Twenty male dogs and 20 female dogs were fed doses 50 times and 4 times greater than the clinically-recommended drug dosages in an acute and a subacute toxicological study, respectively. Adverse effects were examined by comparing the differences between normal and drug-administered groups using clinical signs, necropsies, histopathologic findings, haematology,urinalysis, and biochemical analysis.RESULTS: In the acute study no change in the body weight, diarrhoea, apetite, mortality rate and histopathology of major organs was observed in male or female dogs with a single administration of CGX at 5 g/kg. No drug-induced abnormalities at analysis of histopathology,haematology, urinalysis, and biochemistry were found with any dose of this drug.CONCLUSION: CGX is supposed to be very safe when used in a clinical application with a wide therapeutic index.

  18. Antioxidant and Antiadipogenic Activities of Galkeun-Tang, a Traditional Korean Herbal Formula

    Directory of Open Access Journals (Sweden)

    Soo-Jin Jeong

    2014-01-01

    Full Text Available Galkeun-tang (GKT; Galgen-tang in Chinese and Kakkon-to in Japanese, a traditional herbal formula, has been used for treatment of the common cold. Here, we report in vitro antioxidant and antiadipogenic effects of GKT. GKT increased the activities of scavenging 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid (ABTS and 2,2-diphenyl-1-picrylhydrazyl (DPPH radicals. GKT also significantly reduced the malondialdehyde (MDA generation during low-density lipoprotein (LDL oxidation and the electrophoretic mobility of oxidized LDL, indicating inhibitory effects of GKT on Cu2+-mediated oxidation of LDL. Regarding antiadipogenic activity, GKT treatment significantly suppressed lipid accumulation, triglyceride production, and glycerol-3-phosphate dehydrogenase (GPDH activity in differentiated 3T3-L1 adipocytes. Consistent with this, GKT significantly reduced the secretion of leptin, a major adipokine, in differentiated 3T3-L1 adipocytes. Overall, our findings suggest that GKT has the potential for antioxidative and antiadipogenic properties.

  19. [Research progress of Chinese herbal medicine raw materials in cosmetics].

    Science.gov (United States)

    Xie, Yan-jun; Kong, Wei-jun; Yang, Mei-hua; Yang, Shi-hai

    2015-10-01

    Advocating green, nature, environmental protection, safety and the pursuit of efficacy are the trends of cosmetics in the world. In recent years, more and more Chinese herbal extracts with mild, high safety and small irritation are applied to cosmetics as the natural additives. This has become a new hot spot. The recent application advances of Chinese medicine raw materials in cosmetics are overviewed according to their main functions. This review will provide useful references for the future development and application of Chinese medicinal herbs cosmetics.

  20. Treatment of food anaphylaxis with traditional Chinese herbal remedies – from mouse model to human clinical trials

    Science.gov (United States)

    Wang, Julie

    2014-01-01

    Purpose of review To describe the development of a novel treatment for food allergy, named the food allergy herbal formula-2 (FAHF-2), that is based on Traditional Chinese Medicine. Recent findings FAHF-2 has proven to be safe and effective for the treatment of food allergies in murine models of peanut and multiple food allergies. These results are accompanied by evidence of favorable immune modulation, and the effects are persistent after discontinuation of treatment. Early clinical trials demonstrate the safety and tolerability of this formula in subjects with food allergies. An on-going Phase II clinical trial will evaluate the efficacy of FAHF-2 in protecting individuals from allergen-induced allergic reactions during oral food challenges. Summary FAHF-2 is an herbal formula that has a high safety profile and has shown to prevent anaphylaxis in murine models of food allergy. Similar findings in clinical trials could bring a novel treatment for food allergies. PMID:23799334

  1. Traditional herbal formula Sini Powder extract produces antidepressant-like effects through stress-related mechanisms in rats.

    Science.gov (United States)

    Wei, Shan-Shan; Yang, He-Jin; Huang, Jia-Wen; Lu, Xue-Ping; Peng, Ling-Fang; Wang, Qing-Guo

    2016-08-01

    Sini Powder (SP), a traditional Chinese herbal formula, has long been used to treat depression in patients, although the underlying mechanisms remain to be elucidated. In the present study, we found that rats treated with SP extract for 7 days showed a significant increase in swimming time and reduction in immobility time in forced swimming test in a dose-dependent manner, without changes in locomotion. These effects could be attributed to SP's modulation of the hypothalamus-pituitary-adrenal axis, because a single pretreatment of SP extract could rescue increased serum corticosterone and plasma adrenocorticotropin levels induced by acute elevated platform stress. A single pretreatment of SP extract could also elevate the mRNA expression of hippocampal glucocorticoid receptors. In conclusion, our results suggest that SP extract may act as an anti-stress medication to produce antidepressant-like effects.

  2. Prescriptions of Chinese Herbal Medicines for Insomnia in Taiwan during 2002

    Directory of Open Access Journals (Sweden)

    Fang-Pey Chen

    2011-01-01

    Full Text Available Chinese herbal medicine (CHM has been commonly used for treating insomnia in Asian countries for centuries. The aim of this study was to conduct a large-scale pharmaco-epidemiologic study and evaluate the frequency and patterns of CHM use in treating insomnia. We obtained the traditional Chinese medicine (TCM outpatient claims from the National Health Insurance in Taiwan for the year 2002. Patients with insomnia were identified from the diagnostic code of International Classification of Disease among claimed visiting files. Corresponding prescription files were analyzed, and an association rule was applied to evaluate the co-prescription of CHM. Results showed that there were 16 134 subjects who visited TCM clinics for insomnia in Taiwan during 2002 and received a total of 29 801 CHM prescriptions. Subjects between 40 and 49 years of age comprised the largest number of those treated (25.3%. In addition, female subjects used CHMs for insomnia more frequently than male subjects (female : male = 1.94 : 1. There was an average of 4.8 items prescribed in the form of either an individual Chinese herb or formula in a single CHM prescription for insomnia. Shou-wu-teng (Polygonum multiflorum was the most commonly prescribed single Chinese herb, while Suan-zao-ren-tang was the most commonly prescribed Chinese herbal formula. According to the association rule, the most commonly prescribed CHM drug combination was Suan-zao-ren-tang plus Long-dan-xie-gan-tang, while the most commonly prescribed triple drug combination was Suan-zao-ren-tang, Albizia julibrissin, and P. multiflorum. Nevertheless, further clinical trials are needed to evaluate the efficacy and safety of these CHMs for treating insomnia.

  3. Prescriptions of Chinese Herbal Medicines for Insomnia in Taiwan during 2002.

    Science.gov (United States)

    Chen, Fang-Pey; Jong, Maw-Shiou; Chen, Yu-Chun; Kung, Yen-Ying; Chen, Tzeng-Ji; Chen, Fun-Jou; Hwang, Shinn-Jang

    2011-01-01

    Chinese herbal medicine (CHM) has been commonly used for treating insomnia in Asian countries for centuries. The aim of this study was to conduct a large-scale pharmaco-epidemiologic study and evaluate the frequency and patterns of CHM use in treating insomnia. We obtained the traditional Chinese medicine (TCM) outpatient claims from the National Health Insurance in Taiwan for the year 2002. Patients with insomnia were identified from the diagnostic code of International Classification of Disease among claimed visiting files. Corresponding prescription files were analyzed, and an association rule was applied to evaluate the co-prescription of CHM. Results showed that there were 16 134 subjects who visited TCM clinics for insomnia in Taiwan during 2002 and received a total of 29 801 CHM prescriptions. Subjects between 40 and 49 years of age comprised the largest number of those treated (25.3%). In addition, female subjects used CHMs for insomnia more frequently than male subjects (female : male = 1.94 : 1). There was an average of 4.8 items prescribed in the form of either an individual Chinese herb or formula in a single CHM prescription for insomnia. Shou-wu-teng (Polygonum multiflorum) was the most commonly prescribed single Chinese herb, while Suan-zao-ren-tang was the most commonly prescribed Chinese herbal formula. According to the association rule, the most commonly prescribed CHM drug combination was Suan-zao-ren-tang plus Long-dan-xie-gan-tang, while the most commonly prescribed triple drug combination was Suan-zao-ren-tang, Albizia julibrissin, and P. multiflorum. Nevertheless, further clinical trials are needed to evaluate the efficacy and safety of these CHMs for treating insomnia.

  4. Chinese herbal medicine for insomnia: a systematic review of randomized controlled trials.

    Science.gov (United States)

    Yeung, Wing-Fai; Chung, Ka-Fai; Poon, Maggie Man-Ki; Ho, Fiona Yan-Yee; Zhang, Shi-Ping; Zhang, Zhang-Jin; Ziea, Eric Tat-Chi; Wong, Vivian Taam

    2012-12-01

    Chinese herbal medicine (CHM), either in single herb or in herbal formula, has been used to treat insomnia for more than 2000 years. A systematic review including Chinese and English literature of randomized controlled trials was conducted to examine the efficacy, safety, and composition of CHM for insomnia. Among the 217 studies we have reviewed, only eight had a Jadad score ≥3, and seven out of these eight studies had at least one domain with high risks of bias. Meta-analyses of the studies with Jadad score ≥3 found that CHM was similar to Western medication (three studies) and placebo (three studies) in treating insomnia. Due to the poor methodological quality of the studies and the small number of trials included in meta-analyses, the current evidence is insufficient to support the efficacy of CHM for insomnia. The frequency of adverse events associated with CHM was similar to that of placebo, but lower than with Western medication. Gui Pi Tang was the most commonly used standardized formula, while Suan Zao Ren (Ziziphus jujuba) was the most frequently used single herb. Further studies with a double-blind placebo-controlled design are needed to accurately determine the benefits and risks of CHM for insomnia.

  5. Prescription Pattern of Chinese Herbal Products for Diabetes Mellitus in Taiwan: A Population-Based Study

    Directory of Open Access Journals (Sweden)

    Chung-Yu Huang

    2013-01-01

    Full Text Available Background. Traditional Chinese medicine (TCM, when given as a therapy for symptom relief, has gained widespread popularity among diabetic patients. The aim of this study is to analyze the utilization of TCM among type 2 diabetic patients in Taiwan. Methods. The use of TCM for type 2 diabetic patients were evaluated using a randomly sampled cohort of 1,000,000 beneficiaries recruited from the National Health Insurance Research Database. Results. Overall, 77.9% (n=31,289 of type 2 diabetic patients utilized TCM and 13.9% (n=4,351 of them used TCM for the treatment of type 2 diabetes. Among the top ten most frequently prescribed herbal formulae, four remedies, Zhi-Bo-Di-Huang-Wan, Qi-Ju-Di-Huang-Wan, Ji-Sheng-Shen-Qi-Wan and Ba-Wei-Di-Huang-Wan are derivative formulae of Liu-Wei-Di-Huang-Wan. In other words, Liu-Wei-Di-Huang-Wan and its derivatives were found to be the most common herbal formulae prescribed by TCM doctors for the treatment of diabetes in Taiwan. Conclusion. Although some evidence does support the use TCM to treat diabetes, the results from the current study may have been confounded by placebo effect, which emphasize the need for well conducted, double-blind, randomized, placebo-controlled studies in order to further evaluate the efficacy of Liu-Wei-Di-Huang-Wan on patients with type 2 diabetes.

  6. TREATMENT OF ASTHMA AND FOOD ALLERGY WITH HERBAL INTERVENTIONS FROM TRADITIONAL CHINESE MEDICINE

    Science.gov (United States)

    Li, Xiu-Min

    2014-01-01

    Prevalence of asthma and allergy has increased over the past 2–3 decades in Westernized countries. Despite increased understanding of the pathogenesis of asthma and allergic diseases, control of severe asthma is still difficult. Asthma is also associated with high prevalence of anxiety in particular adolescents. There is no effective treatment for food allergy. Food allergy is often associated with severe and recalcitrant eczema. Novel approaches for treatment of asthma and food allergy and comorbid conditions are urgently needed. Traditional Chinese medicine (TCM), used in Asia for centuries, is beginning to play a role in Western health care. There is increasing scientific evidence supporting the use of TCM for asthma treatment. This review article discusses promising TCM interventions for asthma, food allergy and comorbid conditions and explores their possible mechanisms of action. Since 2005, several controlled clinical studies of “anti-asthma” herbal remedies have been published. Among the herbal medicines, anti-asthma herbal medicine intervention (ASHMI) is the only anti-asthma TCM product that is a US FDA investigational new drug (IND) that has entered clinical trials. Research into ASHMI’s effects and mechanisms of actions in animal models is actively being pursued. Research on TCM herbal medicines for treating food allergy is rare. The herbal intervention, Food Allergy Herbal Formula-2 (FAHF-2) is the only US FDA botanical IND under investigation as a multiple food allergy therapy. Published articles and abstracts, as well as new data generated in preclinical and clinical studies of ASHMI and FAHF-2 are the bases for this review. The effect of TCM therapy on food allergy associated recalcitrant eczema, based on case review, is also included. Laboratory and clinical studies demonstrate a beneficial effect of ASHMI treatment on asthma. The possible mechanisms underlying the efficacy are multiple. Preclinical studies demonstrated the efficacy and

  7. Modernization of Chinese herbal compound and the high performance liquid chromatography tandem mass spectrometry (HPLC-MS)

    Institute of Scientific and Technical Information of China (English)

    LI Wen-lan; SUN Zhi; DU Juan

    2008-01-01

    Chinese herbal compound is playing an important role on curing human diseases. And it has been a trend that Chinese herbal compound is being used all over the world in 21 century. However, our Chinese herbal compound is facing serious challenge for the lack of canonical system of quality criterion for Chinese herbal compound so it has been a urgent problem to set up the quality control standards and reveal therapeutic basis of Chinese herbal compound. In order to give full play to the advantages of Chinese herbal compound, modern scientific and technological is used to research of Chinese herbal compound, especially the high performance liquid chromatography tandem mass spectrometry(HPLC-MS), because it is high sensitive, rapid, and obtain more information. It is very necessary that HPLC-MS is uesed to elucidate the effective components of basic substances of Chinese Herbal Compound, and endow traditional Chinese medicine with modern scientific connotation.

  8. Chemical and Physical Methods to Analyze a Multicomponent Traditional Chinese Herbal Prescription Using LC-MS/MS, Electron Microscope, and Congo Red Staining.

    Science.gov (United States)

    Lu, Chia-Ming; Hou, Mei-Ling; Lin, Lie-Chwen; Tsai, Tung-Hu

    2013-01-01

    This study develops several chemical and physical methods to evaluate the quality of a traditional Chinese formulation, Jia-Wei-Xiao-Yao-San. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) coupled with electrospray ionization was used to measure the herbal biomarkers of saikosaponin A, saikosaponin D, ferulic acid, and paeoniflorin from this herbal formula. A scanning electron microscope (SEM) and light microscopy photographs with Congo red staining were used to identify the cellulose fibers if raw herbal powder had been added to the herbal pharmaceutical product. Moreover, water solubility and crude fiber content examination were used to inspect for potential herbal additives to the herbal pharmaceutical products. The results demonstrate that the contents of the herbal ingredients of saikosaponin A, saikosaponin D, ferulic acid, and paeoniflorin were around 0.351 ± 0.017, 0.136 ± 0.010, 0.140 ± 0.005, and 2.281 ± 0.406 mg/g, respectively, for this herbal pharmaceutical product. The physical examination data demonstrate that the raw herbal powder had rough, irregular, lumpy, filamentous, and elongated shapes, as well as strong Congo red staining. In addition, water solubility and crude fiber content were not consistent in the herbal pharmaceutical products.

  9. Chemical and Physical Methods to Analyze a Multicomponent Traditional Chinese Herbal Prescription Using LC-MS/MS, Electron Microscope, and Congo Red Staining

    Directory of Open Access Journals (Sweden)

    Chia-Ming Lu

    2013-01-01

    Full Text Available This study develops several chemical and physical methods to evaluate the quality of a traditional Chinese formulation, Jia-Wei-Xiao-Yao-San. Liquid chromatography-tandem mass spectrometry (LC-MS/MS coupled with electrospray ionization was used to measure the herbal biomarkers of saikosaponin A, saikosaponin D, ferulic acid, and paeoniflorin from this herbal formula. A scanning electron microscope (SEM and light microscopy photographs with Congo red staining were used to identify the cellulose fibers if raw herbal powder had been added to the herbal pharmaceutical product. Moreover, water solubility and crude fiber content examination were used to inspect for potential herbal additives to the herbal pharmaceutical products. The results demonstrate that the contents of the herbal ingredients of saikosaponin A, saikosaponin D, ferulic acid, and paeoniflorin were around 0.351 ± 0.017, 0.136 ± 0.010, 0.140 ± 0.005, and 2.281 ± 0.406 mg/g, respectively, for this herbal pharmaceutical product. The physical examination data demonstrate that the raw herbal powder had rough, irregular, lumpy, filamentous, and elongated shapes, as well as strong Congo red staining. In addition, water solubility and crude fiber content were not consistent in the herbal pharmaceutical products.

  10. [Evaluation of the importance of herbs in the Chinese herbal compounds based on the theory of rough sets].

    Science.gov (United States)

    Liu, Minbi

    2013-10-01

    The theory of rough sets has been applied to evaluate the importance of each herb in the Chinese herbal compounds in this study. This method could distinguish core herbs through different syndrome types in the same class of prescription by measuring the importance of attributes. Compared to the frequency statistical method, the rough sets method could reveal law of compatibility in categorized formula more deeply. This study gives some guidance to clinical application of herbs and the drug screening in the development of new Chinese traditional medicine.

  11. Chinese Herbal Medicine on Cardiovascular Diseases and the Mechanisms of Action

    OpenAIRE

    Cuiqing Liu; Yu Huang

    2016-01-01

    Cardiovascular diseases are the principal cause of death worldwide. The potentially serious adverse effects of therapeutic drugs lead to growing awareness of the role of Chinese herbal medicine in the treatment of cardiovascular diseases. Chinese herbal medicine has been widely used in many countries especially in China from antiquity, however, the mechanisms by which herbal medicine acts in the prevention and treatment of cardiovascular diseases are far from clear. In this review, we briefly...

  12. Geniposide, the component of the Chinese herbal formula Tongluojiunao, protects amyloid-βpeptide (1-42)-mediated death of hippocampal neurons via the non-classical estrogen signaling pathway

    Institute of Scientific and Technical Information of China (English)

    Jiao Li; Yan Tan; Qi Zhang; Xu Wang; Angran Fan; Qian Hua; Feng Wang; Haimin Ding; Chunyan Jin; Jinyan Chen; Yanan Zhao; Xiaojing Li; Wenju Chen; Ping Sun

    2014-01-01

    Tongluojiunao (TLJN) is an herbal medicine consisting of two main components, geniposide and ginsenoside Rg1. TLJN has been shown to protect primary cultured hippocampal neurons. How-ever, its mechanism of action remains unclear. In the present study, primary cultured hippocampal neurons treated with Aβ1-42 (10 µmol/L) signiifcantly increased the release of lactate dehydroge-nase, which was markedly reduced by TLJN (2 µL/mL), speciifcally by the component geniposide (26 µmol/L), but not ginsenoside Rg1 (2.5 µmol/L). hTe estrogen receptor inhibitor, ICI182780 (1 µmol/L), did not block TLJN-or geniposide-mediated decrease of lactate dehydrogenase under Aβ1-42-exposed conditions. However, the phosphatidyl inositol 3-kinase or mitogen-activated protein kinase pathway inhibitor, LY294002 (50 µmol/L) or U0126 (10 µmol/L), respectively blo cked the decrease of lactate dehydrogenase mediated by TLJN or geniposide. hTerefore, these results suggest that the non-classical estrogen pathway (i.e., phosphatidyl inositol 3-kinase or mitogen-activated protein kinase) is involved in the neuroprotective effect of TLJN, speciifcally its component, geniposide, against Aβ1-42-mediated cell death in primary cultured hippocampal neurons.

  13. Diseases,formula and Chinese herbal medicines:a study on spleen-stom-ach dampness-heat pattern based on modern literature%基于现代文献的脾胃湿热证疾病分布及处方用药研究

    Institute of Scientific and Technical Information of China (English)

    刘路路; 李婷婷; 吴秀艳; 王天芳; 薛晓琳; 罗清香; 张晓娜; 任红; 侯帅颖; 张佳元

    2016-01-01

    :脾胃湿热证) as subject term or title /keyword,the databases of China National Knowledge Infrastructure(CNKI),Wan-fang Data Knowledge Service Platform and VIP Information were systematically retrieved,from the begin-ning of the databases to 31 December,2015.The articles related to treatment on SSDHP were collected, and the database was established by using Microsoft Excel 2010,on which data were descriptively statisti-cal analyzed.Results 109 articles were eligible from total 1 681 retrieved ones.The top two diseases with SSDHP were digestive system disorders (86.41%)and dermatoses (5.83%).The common formu-la directed at clearing heat and dampness including Pingwei Powder,Huopu Xialing Decoction,and Sanren Decoction,combined with specific medications for exact symptoms.The common Chinese herbal medications with frequency more than 1 percent were listed as the following:Golden Thread (Huangli-an),Pinellia Tuber(Banxia),Official Magnolia Bark(Houpu),Liquorice Root (Gancao),Dried De-coctionerine Peel (Chenpi),Baical Skullcap Root (Huangqin),Indian Bread (Fuling),Dandelion (Pugongying),Agastache Rugosus (Huoxiang),Atractylodes Rhizome (Cangzhu),Coix Seed (Yiy-iren),Round Cardamon Fruit (Baidoukou),Largehead Atractylodes Rhizome (Baizhu),Orange Fruit (Zhiqiao),Immature Orange Fruit (Zhizi ),Corydalis Rhizoma (Yanhusuo ),White Peony Root (Baishao),Medicinal Evodia Fruit (Wuzhuyu),Dried Ginger (Ganjiang),Bamboo Shavings (Zhu-ru),Virgate Wormwood Herb (Yinchen),Grassleaf Sweetflag Rhizome (Shichangpu),Turmeric Root Tuber (Yujin),Immature Orange Fruit (Zhishi),Chinese Thorowax Root(Chaihu),Common Bletilla Tuber (Baiji),Danshan Root (Danshen),Bitter Apricot Seed (Kuxingren),Villous Amomum Fruit (Sharen),Common Aucklandia Root (Muxiang),Finger Citron (Foshou),Talc (Huashi).Conclu-sion Now,the diseases with SSDHP were most common in digestive system,but also in other systems. And the prescription and Chinese herbal medicines should be applied by holistic conception,combination of disease and

  14. Genotoxic and tumorigenic pyrrolizidine alkaloids in Chinese herbal plants

    Institute of Scientific and Technical Information of China (English)

    P.P. Fu; Q. Xia; M.W. Chou; G. Lin

    2005-01-01

    Pyrrolizidine alkaloids are a class of hepatotoxic and tumorigenic compounds detected in Chinese herbal plants,contaminated foods, and dietary supplements. In this review, the sources, toxicity, genotoxicity, tumorigenicity, and the metabolic pathways,particular the activation pathways leading to hepatotoxicity and tumorigenicity, of pyrrolizidine alkaloids are briefly discussed, with a focus on the most recent important findings concerning the genotoxic mechanism by which riddelliine liver tumors. This mechanism involves the formation of 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP)-derived DNA adducts and may be general to most carcinogenic pyrrolizidine alkaloids.

  15. Discrimination of Chinese Herbal Medicine by Machine Olfaction

    Directory of Open Access Journals (Sweden)

    Yawen Shao

    2013-02-01

    Full Text Available “Small Sample Size” (SSS problem would occur while using linear discriminant analysis (LDA algorithm with traditional Fisher criterion if the within-class scatter matrix is singular. The combination of maximum scatter difference (MSD criterion and LDA algorithm for solve SSS problem is described. It is employed to detect three kinds of Chinese herbal medicines from different growing areas by machine olfaction. Compared with PCA or PCA + LDA algorithm, the classification result was enhanced. It works out that only a few samples of Anhui Atractylodes are classified incorrectly, however, the classification rate reaches 97.8%.

  16. Yokukan-san: a review of the evidence for use of this Kampo herbal formula in dementia and psychiatric conditions

    Directory of Open Access Journals (Sweden)

    Okamoto H

    2014-09-01

    Full Text Available Hideki Okamoto,1,2 Masaomi Iyo,2 Keigo Ueda,1 Cheolsun Han,1 Yoshiro Hirasaki,1 Takao Namiki1 1Department of Japanese-Oriental (Kampo Medicine, 2Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba City, Japan Abstract: Japanese traditional herbal medicine (Kampo has its origins in traditional Chinese medicine (TCM. It was introduced to Japan in the middle of the sixth century and has evolved over the past 1,400 years after combining with Japan’s original folk remedies. While it retains some similarities to TCM, Kampo has evolved in Japan, resulting in a system of medicine that has many differences from TCM. Kampo medicine is considered to be very safe; in Japan, Kampo herbal formulas are manufactured by licensed pharmaceutical companies, prescribed by Western-trained medical doctors (usually as a freeze-dried extract, and have quality control standards similar to those of prescription drugs. The present study examined Yokukan-san (Yi-Gan San in TCM, a Kampo formula that has been used empirically in Japan for more than 400 years. Accumulating clinical trials have demonstrated Yokukan-san’s efficacy in treating patients with behavioral and psychological symptoms of dementia, which has resulted in the Japanese Society of Neurology listing it in the Japanese Guidelines for the Management of Dementia 2010. Efficacy in other diseases and conditions, such as sleep disorders, tardive dyskinesia, aggression, and impulsivity has also been reported. This article reviews both clinical and basic studies of Yokukan-san, with the goal of clarifying its clinical indications. Keywords: Yokukan-san-ka-chimpi-hange, Japanese traditional medicine, Asian medicine, dementia with Lewy bodies (DLB, Alzheimer’s disease, BPSD, Parkinson’s disease

  17. New Progress in Modern Research on Chinese Herbal Medicines Published in Chinese Traditional and Herbal Drugs in 2010: Annual Highlights and Comments

    Institute of Scientific and Technical Information of China (English)

    HE Chun-nian; LIU Yan-ze; XIAO Pei-gen

    2011-01-01

    As a series of and continuous publication,the papers published on Chinese Traditional and Herbal Drugs in 2010 were selectively and briefly highlighted to reflect the new progress on modern research of Chinese herbal medicines.Within 617 articles,chemical constituents (127),pharmaceutics and technology (149),pharmacological studies and clinical observation,and medicinal materials are still major categories.Some comments have also been personally provided.

  18. Chinese Herbal Products for Female Infertility in Taiwan: A Population-Based Cohort Study.

    Science.gov (United States)

    Hung, Yu-Chiang; Kao, Chao-Wei; Lin, Che-Chen; Liao, Yen-Nung; Wu, Bei-Yu; Hung, I-Ling; Hu, Wen-Long

    2016-03-01

    Female infertility and low birth rate are significant public health issues with profound social, psychological, and economic consequences. Some infertile women resort to conventional, complementary, or alternative therapies to conceive. The aim of this study was to identify the Chinese herbal products (CHPs) most commonly used for female infertility in Taiwan. The usage of traditional Chinese medicine (TCM) and the frequency of CHP prescriptions to infertile women were determined based on a nationwide 1-million randomly sampled cohort of National Health Insurance Research Database beneficiaries. Descriptive statistics and multiple logistic regression analysis were employed to estimate the adjusted odds ratio (aOR) for TCM usage and potential risk factors. In total, 8766 women with newly diagnosed infertility were included in this study. Of those, 8430 (96.17%) had sought TCM treatment in addition to visiting the gynecologist. We noted that female infertility patients with risk factors (e.g., endometriosis, uterine fibroids, or irregular menstrual cycle) were more likely to use TCM than those without TCM medication (aOR = 1.83, 1.87, and 1.79, respectively). The most commonly used formula and single CHP were Dang-Gui-Sha-Yao-San (17.25%) and Semen Cuscutae (27.40%), respectively. CHP formula combinations (e.g., Dang-Gui-Sha-Yao-San plus Wen-Jing-Tang 3.10%) or single Chinese herbal combinations (e.g., Semen Cuscutae plus Leonurus japonicus 6.31%) were also commonly used to treat female infertility. Further well-conducted, double-blind, randomized, placebo-controlled studies will be needed to evaluate the efficacy and safety of these CHP combinations for female infertility.

  19. Placebos used in clinical trials for Chinese herbal medicine.

    Science.gov (United States)

    Qi, Guan D; We, Ding A; Chung, Leung P; Fai, Cheng K

    2008-06-01

    One of the important components in randomized Controlled Trial (RCT) is blinding. The gold standard of clinical trials is to achieve a double blind design. However, only a small number of randomized controlled trials in traditional Chinese medicine have been reported, most of them are of poor quality in methodology including placebo preparation and verification. The purpose of the article is to review the validity of placebo used in blinded clinical trials for Chinese herbal medicine (CHM) in recent years and related patents. We searched the Wanfang Database (total of 827 Chinese journals of medicine and/or pharmacy, from 1999 to 2005) and 598 full-length articles related to placebo clinical trials were found. 77 placebo blinded clinical trials for Chinese medicine were extracted by manual search from the 598 articles. After reviewing the 77 full-length articles, we found that nearly half of the clinical trials did not pay attention to the physical quality of the testing drug and placebo and whether they were of comparable physical quality. The rest provided very limited placebo information so that blinding assurance could not be assumed. Only 2 articles (2.6%) specifically validated the comparability between the testing drug and the placebo. Researchers in Chinese medicine commonly ignored the quality of the placebo in comparison to the test drug. This may be causing bias in the clinical trials. Quality specifications and evaluation of the placebo should deserve special attention to reduce bias in randomized controlled trials in TCM study.

  20. Traditional Chinese herbal remedies for Asthma and Food Allergy

    Science.gov (United States)

    Li, Xiu-Min

    2009-01-01

    The increasing prevalence of allergic diseases in westernized countries is a significant health problem. Curative therapies for these diseases are not available. There are also significant concerns regarding the potential side effects from the chronic use of conventional drugs such as corticosteroids, especially in children. Many patients with chronic allergic conditions seek complementary and alternative medicine (CAM) therapies including traditional Chinese medicines (TCM). This trend has begun to attract interest from the mainstream healthcare providers and scientific investigators, and has stimulated government agencies in the US to provide support and guidance for the scientific investigation of CAM. This effort may lead to improved therapies and better healthcare/patient outcomes. This review presents an update on the most promising Chinese herbal remedies for asthma and food allergy. PMID:17560638

  1. Systematic review of Chinese herbal medicine for functional constipation

    Institute of Scientific and Technical Information of China (English)

    Chung-Wah Cheng; Zhao-Xiang Bian; Tai-Xiang Wu

    2009-01-01

    Constipation is a common gastrointestinal complaint in clinical practice, affecting an estimated 27% of the population. Many patients are disappointed by current conventional treatments and, therefore, seek help from complementary and alternative medicine (CAM). Traditional Chinese medicine, is the most important part of CAM and has been practiced for treating diseases and promoting the health of humans for thousands of years, and has become a popular alternative choice. Although there are many Chinese herbal medicine (CHM) interventions available, and some have been verified by clinical trials, their efficacy and safety are still questioned by both patients and health care providers worldwide. The purposes of this review are, first, to appraise the qualities of individual study designs in the new Cochrane approach. Second, the benefits of individual CHM interventions or individual types of CHM intervention for the treatment of functional constipation are analyzed. Finally, valid and comprehensive conclusions are drawn, if applicable, in order to make clinical recommendations.

  2. [Significance of re-evaluation and development of Chinese herbal drugs].

    Science.gov (United States)

    Gao, Yue; Ma, Zengchun; Zhang, Boli

    2012-01-01

    The research of new herbal drugs involves in new herbal drugs development and renew the old drugs. It is necessary to research new herbal drugs based on the theory of traditional Chinese medicine (TCM). The current development of famous TCM focuses on the manufacture process, quality control standards, material basis and clinical research. But system management of security evaluation is deficient, the relevant system for the safety assessment TCM has not been established. The causes of security problems, security risks, target organ of toxicity, weak link of safety evaluation, and ideas of safety evaluation are discussed in this paper. The toxicology research of chinese herbal drugs is necessary based on standard of good laboratory practices (GLP), the characteristic of Chinese herbal drugs is necessary to be fully integrated into safety evaluation. The safety of new drug research is necessary to be integrated throughout the entire process. Famous Chinese medicine safety research must be paid more attention in the future.

  3. Effects and Mechanisms of Chinese Herbal Medicine in Ameliorating Myocardial Ischemia-Reperfusion Injury

    Directory of Open Access Journals (Sweden)

    Qing Liu

    2013-01-01

    Full Text Available Myocardial ischemia-reperfusion (MIR injury is a major contributor to the morbidity and mortality associated with coronary artery disease, which accounts for approximately 450,000 deaths a year in the United States alone. Chinese herbal medicine, especially combined herbal formulations, has been widely used in traditional Chinese medicine for the treatment of myocardial infarction for hundreds of years. While the efficacy of Chinese herbal medicine is well documented, the underlying molecular mechanisms remain elusive. In this review, we highlight recent studies which are focused on elucidating the cellular and molecular mechanisms using extracted compounds, single herbs, or herbal formulations in experimental settings. These studies represent recent efforts to bridge the gap between the enigma of ancient Chinese herbal medicine and the concepts of modern cell and molecular biology in the treatment of myocardial infarction.

  4. Pharmacological Effects of Active Components of Chinese Herbal Medicine in the Treatment of Alzheimer's Disease: A Review.

    Science.gov (United States)

    Wang, Zhi-Yong; Liu, Jian-Gang; Li, Hao; Yang, Hui-Ming

    2016-01-01

    Alzheimer's disease (AD), the most common neurodegenerative disorder associated with dementia, not only severely decreases the quality of life for its victims, but also brings a heavy economic burden to the family and society. Unfortunately, few chemical drugs designed for clinical applications have reached the expected preventive or therapeutic effect so far, and combined with their significant side-effects, there is therefore an urgent need for new strategies to be developed for AD treatment. Traditional Chinese Medicine has accumulated many experiences in the treatment of dementia during thousands of years of practice; modern pharmacological studies have confirmed the therapeutic effects of many active components derived from Chinese herbal medicines (CHM). Ginsenoside Rg1, extracted from Radix Ginseng, exerts a [Formula: see text]-secretase inhibitor effect so as to decrease A[Formula: see text] aggregation. It can also inhibit the apoptosis of neuron cells. Tanshinone IIA, extracted from Radix Salviae miltiorrhizae, and baicalin, extracted from Radix Scutellariae[Formula: see text] can inhibit the oxidative stress injury in neuronal cells. Icariin, extracted from Epimedium brevicornum, can decrease A[Formula: see text] levels and the hyperphosphorylation of tau protein, and can also inhibit oxidative stress and apoptosis. Huperzine A, extracted from Huperzia serrata, exerts a cholinesterase inhibitor effect. Evodiamine, extracted from Fructus Evodiae, and curcumin, extracted from Rhizoma Curcumae Longae, exert anti-inflammatory actions. Curcumin can act on A[Formula: see text] and tau too. Due to the advantages of multi-target effects and fewer side effects, Chinese medicine is more appropriate for long-term use. In this present review, the pharmacological effects of commonly used active components derived from Chinese herbal medicines in the treatment of AD are discussed.

  5. Searching for a Cure: The FDA's Regulatory Approach to Traditional Chinese Herbal Medicine

    OpenAIRE

    Kim, Anna L.

    1997-01-01

    I will begin this discussion by describing traditional Chinese medicine and how it compares to the Western medical tradition. Second, I will then examine why regulation is necessary given the impact of Chinese herbal medicine on American healthcare. Then, I will proceed to the problem of trying to fit a square peg into a round hole, namely, the issue of regulating Chinese herbal medicine under current statutory provisions. Fourth, I will analyze state and federal responses to alternative ther...

  6. Anti-foot-and-mouth disease virus effects of Chinese herbal kombucha in vivo

    Directory of Open Access Journals (Sweden)

    Naifang Fu

    2015-01-01

    Full Text Available AbstractThe foot and mouth disease virus (FMDV is sensitive to acids and can be inactivated by exposure to low pH conditions. Spraying animals at risk of infection with suspensions of acid-forming microorganisms has been identified as a potential strategy for preventing FMD. Kombucha is one of the most strongly acid-forming symbiotic probiotics and could thus be an effective agent with which to implement this strategy. Moreover, certain Chinese herbal extracts are known to have broad-spectrum antiviral effects. Chinese herbal kombucha can be prepared by fermenting Chinese herbal extracts with a kombucha culture. Previous studies demonstrated that Chinese herbal kombucha prepared in this way efficiently inhibits FMDV replication in vitro. To assess the inhibitory effects of Chinese herbal kombucha against FMDV in vitro, swine challenged by intramuscular injection with 1000 SID50 of swine FMDV serotype O strain O/China/99 after treatment with Chinese herbal kombucha were partially protected against infection, as demonstrated by a lack of clinical symptoms and qRT-PCR analysis. In a large scale field trial, spraying cattle in an FMD outbreak zone with kombucha protected against infection. Chinese herbal kombucha may be a useful probiotic agent for managing FMD outbreaks.

  7. Screening test for anti-Helicobacter pylori activity of traditional Chinese herbal medicines

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    AIM:To evaluate the anti-Helicobacter pylori (H.pylori) activity of 50 traditional Chinese herbal medicines in order to provide the primary evidence for their use in clinical practice.METHODS:A susceptibility test of water extract from 50 selected traditional Chinese herbal medicines for in vitro H.pylori Sydney strain 1 was performed with broth dilution method.Anti-H.pylori activity of the selected Chinese herbal medicines was evaluated according to their minimum inhibitory concentration (MIC).RESULTS:The ...

  8. Anticancer effects of Chinese herbal medicine, science or myth?

    Institute of Scientific and Technical Information of China (English)

    RUAN Wen-jing; LAI Mao-de; ZHOU Jian-guang

    2006-01-01

    Currently there is considerable interest among oncologists to find anticancer drugs in Chinese herbal medicine (CHM).In the past, clinical data showed that some herbs possessed anticancer properties, but western scientists have doubted the scientific validity of CHM due to the lack of scientific evidence from their perspective. Recently there have been encouraging results, from a western perspective, in the cancer research field regarding the anticancer effects of CHM. Experiments showed that CHM played its anticancer role by inducing apoptosis and differentiation, enhancing the immune system, inhibiting angiogenesis, reversing multidrug resistance (MDR), etc. Clinical trials demonstrated that CHM could improve survival, increase tumor response, improve quality of life, or reduce chemotherapy toxicity, although much remained to be determined regarding the objective effects of CHM in human in the context of clinical trials. Interestingly, both laboratory experiments and clinical trials have demonstrated that when combined with chemotherapy, CHM could raise the efficacy level and lower toxic reactions. These facts raised the feasibility of the combination of herbal medicines and chemotherapy, although much remained to be investigated in this area.

  9. Impact of Chinese Herbal Medicine on American Society and Health Care System: Perspective and Concern

    OpenAIRE

    Lu, Winston I.; Lu, Dominic P.

    2014-01-01

    Many Americans, not completely satisfied with traditional western medicine, have turned to alternative and complementary medicine which explains the increasing popularity of the herbal products and the Chinese herbal medicine. The lack of government regulations and the increasing advertisements by the manufactures have created an impression to the common public that the natural herbal remedies are inherently safer and cheaper than conventional medicine. The skyrocketing rise of healthcare cos...

  10. Prevention and Treatment of Osteoporosis with Chinese Herbal Medicines

    Institute of Scientific and Technical Information of China (English)

    ZHAO Xiao-ling; FENG Yu-xiong; PENG Yong

    2012-01-01

    In this paper,laboratory reports,medication rules,formulating principles,and research methods are summarized and analyzed,including single herb,compound herbs,and the problems in the prevention and treatment of osteoporosis(OP)within the past decade.With widely recognized efficacy,satisfying achievements have been achieved in preventing and treating OP with Chinese herbal medicines(CHM).However,due to the complex constituents,the pharmacological activities and mechanism of CHM are not clear yet,and there is no unified standard on the diagnosis and syndrome differentiation of OP and the efficacy evaluation of CHM in the treatment.Accordingly,the research in the future should focus on the pharmacology and standardization of CHM in treating OP.

  11. Treatment with a herbal formula B401 enhances neuroprotection and angiogenesis in the R6/2 mouse model of Huntington’s disease

    Directory of Open Access Journals (Sweden)

    Wang SE

    2015-02-01

    Full Text Available Sheue-Er Wang,1 Ching-Lung Lin,1 Chih-Hsiang Hsu,1 Shuenn-Jyi Sheu,2 Chiang-Ting Chien,1 Chung-Hsin Wu1 1Department of Life Science, National Taiwan Normal University, 2Brion Research Institute of Taiwan, Taipei, Taiwan Abstract: Huntington’s disease (HD is a neurodegenerative disease characterized by motor dysfunction and early death. Despite years of research, the mechanisms responsible for chronic neurodegeneration of HD remain elusive. Chinese traditional medicines might provide new insights or new therapy for HD. The Chinese herbal formula B401 is a well-known Taiwan–US patent formula and a health supplement for promoting blood circulation and enhancing brain function. This study aimed to elucidate the neuroprotective effects of the Chinese herbal formula B401 on the syndrome of HD. Then, we compared the life span and body weight of R6/2 HD mice with and without oral B401 treatment. The ameliorative effects of B401 on the symptom of HD mice were investigated through behavior tests. Expressions of proteins for neuroprotection, angiogenesis, and inflammation in the brain tissue of R6/2 HD mice were compared by using immunostaining and Western blotting techniques. Our study in vitro showed that viabilities of glutamate-treated SH-SY5Y cells were significantly increased under B401 treatment. Our results in vivo showed that duration of survival was increased, body weight loss was reduced, and motor ability was improved in R6/2 HD mice under oral B401 treatment. Subcutaneous microcirculation was enhanced in 3-month R6/2 HD mice under intraperitoneal B401 injections as observed by using moorFLPI laser Doppler imager. Atrophy of cerebrum, midbrain, and cerebellum in 3-month R6/2 HD mice under oral B401 treatment was alleviated as observed by utilizing magnetic resonance imaging. Evidence from immunostaining and Western blotting analysis showed that expressions of mutant huntingtin and tumor necrosis factor-alpha were reduced, while expressions

  12. Effect of Chinese Herbal Medicine on Immunohistochemistry of Harder's Glands of Chickens

    Institute of Scientific and Technical Information of China (English)

    SHEN Ping; GAO Guisheng; SHI Qiumei; LI Min

    2009-01-01

    To investigate the mechanism of action of Chinese herbal medicine, the immunocells of Harder's glands were observed.The healthy Hy-Line Brown chickens of 12-day-old were divided into three groups randomly. The chickens in group 1 and 2 drank the water with 0.5% and 1% Chinese herbal medicine immunopromoter every day. The chickens in group 3 as control drank pure water. The Harder's glands of the chickens from 0.5% group, 1% group and control group at 24, 36 and 48 d after drinking medicine respectively were made into histological section. And then the histological sections were observed histologically. The results showed that Chinese herbal medicine could increase the quantity of the immunocells in glandular organs conspicuously. Immunopotentiator of Chinese herbal medicine could promote the amount and growth of secreted immunoglobuline and elevate the immune level of the organism, and the effect of 1% group was higher than that of 0.5% group.

  13. Herbal Formula Danggui-Shaoyao-San Promotes Neurogenesis and Angiogenesis in Rat Following Middle Cerebral Artery Occlusion

    Science.gov (United States)

    Ren, Changhong; Wang, Brian; Li, Ning; Jin, Kunlin; Ji, Xunming

    2015-01-01

    Current studies demonstrated that traditional Chinese herbal formula Danggui-Shaoyao-San (DSS) is not only used for the treatment of menstrual disorder, but has also found its use in neurological diseases. However, the neuroprotective role of DSS on ischemia-induced brain injury is still unclear. The aim of the present study is to explore the effect of DSS in ischemic brain injury. Total 30 adult female Sprague–Dawley rats underwent 90 min transient middle cerebral artery occlusion (MCAO). DSS (600 mg/kg) was administered through the intragastric route at the time of reperfusion and then performed every day thereafter until sacrifice. Results showed that DSS treatment significantly improved neurobehavioral outcomes (N=10 per group, P<0.05). Immunohistochemical staining showed that microvessel density in the perifocal region of DSS-treated rats was significantly increased compared to the saline-treated group (N=4 per group, P<0.01). Similarly, the numbers of BrdU+/DCX+ cells in the subventricular zone were increased in DSS-treated rats compared to the saline-treated group (P<0.05). Furthermore, we demonstrated that DSS treatment activated vascular endothelial growth factor (N=4 per group, P<0.05) and promoted eNOS phosphorylation (N=4 per group, P<0.05). Thus, we concluded that DSS promoted focal angiogenesis and neurogenesis, and attenuated ischemia-induced brain injury in rats after MCAO, suggesting that DSS is a potential drug for ischemic stroke therapy. PMID:26236546

  14. Gastroprotective effects of Leejung-tang, an oriental traditional herbal formula, on ethanol-induced acute gastric injury in rats.

    Science.gov (United States)

    Shin, In-Sik; Lee, Mee-Young; Lim, Hye-Sun; Seo, Chang-Seob; Ha, Hye-Kyung; Shin, Hyeun-Kyoo

    2013-01-01

    Leejung-tang (LJT, Rechu-to in Japanese and Lizhong-tang in Chinese) is an oriental traditional traditional herbal formula. LJT has been used for treatment of gastrointestinal disorders in Korea, Japan, and China for a long time. In present study, we investigated the protective effects of LJT against absolute ethanol induced gastric injuries. Rats in the control group were given PBS orally (5 mL/kg body weight) as the vehicle, and the absolute-ethanol group (EtOH group) received absolute ethanol (5 mL/kg body weight) by oral gavage. Rats in the positive control group were given omeprazole orally (50 mg/kg body weight) 2 h prior to the administration of absolute ethanol. The treatment groups received LJT (400 mg/kg body weight) 2 h prior to absolute ethanol administration. All rats were sacrificed 1 h after receiving the ethanol treatment. The stomach was excised for macroscopic examination and biochemical analysis. The administration of LJT protected gastric mucosa against ethanol-induced acute gastric injury, including hemorrhage and hyperemia. LJT reduced the increase in lipid peroxidation in ethanol-induced acute gastric lesions. LJT increased GSH content and activities of the antioxidant enzymes, catalase, glutathione-S-transferase, glutathione reductase, glutathione peroxidase, and superoxide dismutase. These results indicate that LJT protects gastric mucosa against ethanol-induced acute gastric injury by increasing their antioxidant content. We suggest that LJT can be developed as an effective drug for the treatment of acute gastric injury.

  15. Chinese herbal medicines as adjuvant treatment during chemo- or radio-therapy for cancer.

    Science.gov (United States)

    Qi, Fanghua; Li, Anyuan; Inagaki, Yoshinori; Gao, Jianjun; Li, Jijun; Kokudo, Norihiro; Li, Xiao-Kang; Tang, Wei

    2010-12-01

    Numerous studies have indicated that in cancer treatment Chinese herbal medicines in combination with chemo- or radio-therapy can be used to enhance the efficacy of and diminish the side effects and complications caused by chemo- and radio-therapy. Therefore, an understanding of Chinese herbal medicines is needed by physicians and other health care providers. This review provides evidence for use of Chinese herbal medicines as adjuvant cancer treatment during chemo- or radio-therapy. First, Chinese herbal medicines (e.g. Astragalus, Turmeric, Ginseng, TJ-41, PHY906, Huachansu injection, and Kanglaite injection) that are commonly used by cancer patients for treating the cancer and/or reducing the toxicity induced by chemo- or radio-therapy are discussed. Preclinical and clinical studies have shown that these Chinese herbal medicines possess great advantages in terms of suppressing tumor progression, increasing the sensitivity of chemo- and radio-therapeutics, improving an organism's immune system function, and lessening the damage caused by chemo- and radio-therapeutics. Second, clinical trials of Chinese herbal medicines as adjuvant cancer treatment are reviewed. By reducing side effects and complications during chemo- and radio-therapy, these Chinese herbal medicines have a significant effect on reducing cancer-related fatigue and pain, improving respiratory tract infections and gastrointestinal side effects including diarrhea, nausea, and vomiting, protecting liver function, and even ameliorating the symptoms of cachexia. This review should contribute to an understanding of Chinese herbal medicines as adjuvant treatment for cancer and provide useful information for the development of more effective anti-cancer drugs.

  16. Immunomodulatory activities of five clinically used Chinese herbal polysaccharides

    Directory of Open Access Journals (Sweden)

    Aiping Lu

    2012-02-01

    Full Text Available Polysaccharide is a natural macromolecular compound with complex, important and multifaceted biological activities. Some of polysaccharides have been marketed in China as drugs or healthy products. More studies confirm that the active ingredient of many traditional Chinese medicine exist in the form of polysaccharides. They play a role in disease therapy by activating immune cells and the complement system; regulating the cytokines expression; promoting the production of antibodies; inhibiting tumor cell proliferation and inducing tumor cell apoptosis; inhibiting virus entering cells and replication; increasing activity of antioxidant enzyme; scavenging free radicals; and inhibiting lipid peroxidation. In this review, we focus on the immunomodulatory effects and its possible mechanism of polysaccharides from Chinese herbal polysaccharides products, including Lentinan, Astragalus polysaccharide, Polyporus polysaccharide and Achyranthes bidentata polysaccharide. The immunomodulatory activities of polysaccharides were categorized in the paper into general immunoregulatory activity, anti-tumor, anti-infections, anti-inflammatory, anti-oxidative, anti-mutagenic and radioprotective, anti-complementary, anti-adhesive, and anti-allergy since all the activities are related to modulate immune responses by the polysaccharides. Also the challenges in the research of polysaccharides will be discussed. [J Exp Integr Med 2012; 2(1.000: 15-27

  17. Methemoglobinemia development after ingestion of a chinese herbal medicine: A case report

    Directory of Open Access Journals (Sweden)

    Se Eun Hyun

    2010-03-01

    Full Text Available An 8-year-old girl visited the emergency room with perioral cyanosis and dyspnea, which had developed 20 hrs prior to the hospital visit. She had taken a Chinese herbal medication for 3 days prior to the onset of the symptoms. A co-oximeter examination revealed a methemoglobin level of 23.7%. An intravenous infusion of methylene blue was administered. Chemical analysis of the herbal medication revealed an ammonia (NH3 level of 239.41 mg/L. More studies are needed on the correlation between methemoglobinemia and the components of Chinese herbal medicines.

  18. Synergistic effects of Chinese herbal medicine: a comprehensive review of methodology and current research

    Directory of Open Access Journals (Sweden)

    Xian Zhou

    2016-07-01

    Full Text Available Traditional Chinese medicine is an important part of primary health care in Asian countries that has utilised complex herbal formulations (consisting 2 or more medicinal herbs for treating diseases over thousands of years. There seems to be a general assumption that the synergistic therapeutic effects of Chinese herbal medicine derive from the complex interactions between the multiple bioactive components within the herbs and/or herbal formulations. However, evidence to support these synergistic effects remains weak and controversial due to several reasons, including the very complex nature of Chinese herbal medicine, misconceptions about synergy, methodological challenges to study design. In this review, we clarify the definition of synergy, identify common errors in synergy research and describe current methodological approaches to test for synergistic interaction. We discuss the strengthen and weakness of these models in the context of Chinese herbal medicine and summarise the current status of synergy research in CHM. Despite the availability of some scientific data to support the synergistic effects of multi-herbal and/or herb-drug combinations, the level of evidence remains low and the clinical relevancy of most of these findings is undetermined. There remain significant challenges in the development of suitable methods for synergistic studies of complex herbal combinations.

  19. The safety of Homnawakod herbal formula containing Aristolochia tagala Cham. in Wistar rats

    Directory of Open Access Journals (Sweden)

    Tripatara Pinpat

    2012-10-01

    Full Text Available Abstract Background A dried root of Aristolochia tagala Cham. (ATC is often used in Thai traditional medicine as an antipyretic, anti-inflammatory agent, muscle relaxant, appetite-enhancing agent, and analeptic. Homnawakod, an important herbal recipe, originally contains ATC in its formula, however, some Aristolochia species have been reported to cause nephrotoxicity due to aristolochic acid (AA and its derivatives, resulting in ATC removal from all formulae. Therefore, this study investigates the chemical profiles of ATC, the original (HNK+ATC and the present Homnawakod Ayurved Siriraj Herbal Formulary™ (HNK, and investigates whether they could cause nephrotoxicity or aggravate LPS-induced organ injuries in vivo. Methods HPLC and LC/MS were used for chemical profile study. Male Wistar rats were randomly divided into groups in which the rats were intragastrically administered distilled water (2 groups, ATC (10 or 30 mg/kg, HNK+ATC (540 or 1,620 mg/kg, or HNK (1,590 mg/kg for 21 days. A positive control group was administered with single dose 100 mg/kg standard AA-I intragastrically at day 1. Serum creatinine and urea were measured at baseline and at 7, 14 and 21 days of the treatment. On day 22, a model of lipopolysaccharide (LPS-induced endotoxemia was used. One-way and two-way analyses of variance were performed and a P value of less than 0.05 was considered to be significant. Results The similarity of the HPLC chromatograms of HNK+ATC and HNK could suggest that the qualities of both formulae are nearly the same in terms of chemical profile. The amount of AA-I found in ATC is 0.24%w/w. All experimental groups exhibited similar levels of serum urea at baseline and 7 and 14 days of the treatment. At 21 days, rats received AA exhibited a significant increase in serum urea, whereas the others did not exhibit such toxicity. On day 22, there were no significant changes in LPS-induced renal and liver dysfunction, or LPS-induced mean arterial

  20. Java brucea and Chinese herbal medicine for the treatment of cholesterol granuloma in the suprasellar and sellar regions

    Science.gov (United States)

    Sun, Zhe; Cao, Yang; Zhai, Lin-zhu

    2017-01-01

    Abstract Rationale: A cholesterol granuloma (CG) is usually found in the middle ear, papilla, orbits, petrous apex, and choroid plexus, but is highly uncommon in the skull. In spite of benign clinicopathological lesions, bone erosion can be seen occasionally in the patient with CG. The optimal treatment strategy is radical surgery, but complete excision is usually impossible due to anatomical restrictions and a risk of injury to the key structures located nearby. Here, we report a patient with CGs in the suprasellar and sellar regions who was successfully treated with Java brucea and Chinese herbal medicine. Patient concerns: A 31-year-old man presenting with progressive decreased vision in both eyes was analyzed. Diagnoses: A skull magnetic resonance imaging (MRI) scan showed a low-density tumor in the uprasellar and sellar regions and histopathological examination revealed a CG. Interventions: The patient was referred the surgery and radiotherapy. In the meantime, brucea soft capsules and herbal medicine combined were administered to him. Outcomes: The related clinical symptoms and signs resolved significantly after several months, as his therapy progressed. The patient showed no sign of recurrence during the treatment period. Furthermore, he was still alive and disease-free at 37 months of follow-up visit. Lessons: Overall, brucea soft capsules and a Chinese herbal formula treatment combined could be beneficial in improving the patient's quality of life with CG in the skull. PMID:28151875

  1. Screening of Chinese Herbal Medicines Resistant to Chicken Escherichia coli and Infectious Laryngotracheitis Virus

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    [Objective] This study aimed to screen Chinese herbal medicines resistant to Chicken Escherichia coli and infectious laryngotracheitis virus. [Methed] Conven- tional punch method, test tube method and plate dilution method were adopted for in vitro susceptibility test of chicken E, coil strains O5 and O8 using 13 kinds of Chi- nese herbal medicines including Sanguisorba officinalis, Coptis chinensis, Anemar- rhena asphodeloides, Strobilanthes cusia, Agastache rugosa, etc.; chicken embryo inoculation experiment was adopted to screen Chinese herbal medicines resistant to chicken infectious laryngotracheitis virus. [Result] Sanguisorba officinalis, Fructus mume, Rheum officinale, Coptis chinensis, Herba Taraxaci, Anemarrhena asphode- Ioides, Scutellaria baicalensis and Rhizoma Fagopyri Cymosi had ideal antibacterial effect against chicken E. coil strain O5; Sanguisorba officinalis, Fructus mume, Rheum officinale, Coptis chinensis, Herba taraxaci and Rhizoma Fagopyri Cymosi had ideal antibacterial effect against chicken E. coil strain 08; other Chinese herbal medicines showed relatively poor or no antibacterial effect. Results of chicken embryo inoculation experiment showed that nine kinds of Chinese herbal medicines showed relatively strong anti-lLTV effect, including Forsythia suspensa, Radix Isatidis, Fofium isatidis, Flos Ionicerae, Radix codonopsis, Radix astragali, Atractylodes, Radix gly- cyrrhizae, and Pericarpium granati. [Conclusion] The study laid the foundation for fur- ther development of Chinese herbal compound preparations to treat chicken cofibacil- Iosis, infectious laryngotracheitis and other bacterial, viral diseases.

  2. [Research on distribution of patents' holders for Chinese herbal compounds in treating cardiovascular and cerebrovascular based on cluster analysis].

    Science.gov (United States)

    YANG, Xu-Jie; XIAO, Shi-Ying

    2015-09-01

    To discuss the distribution of patents' holders for Chinese herbal compounds in treating cardiovascular and cerebrovascular, the patents' holders for Chinese herbal compounds in treating cardiovascular and cerebrovascular were cluster analyzed by means of simple statistics and cluster analysis. Clustering variables were composed of patent applications, patent maintained number, related papers' quantity, etc. Chinese herbal compound patents' holders were divided into four categories according to their different scientific research and patent strength. It is the magic weapon for Chinese herbal compound patents' holders that have scientific research patents' transforming and make coordination of patent protection and scientific innovation.

  3. Prescription Pattern of Chinese Herbal Products for Breast Cancer in Taiwan: A Population-Based Study

    Directory of Open Access Journals (Sweden)

    Jung-Nien Lai

    2012-01-01

    Full Text Available Background. Chinese herbal products (CHPs given as a therapy for symptom relief have gained widespread popularity among women with breast cancer. The aim of this study was to analyze the utilization of CHP among women with breast cancer in Taiwan. Methods. The usage, frequency of services, and CHP prescribed for breast cancer among women with breast cancer were evaluated, recruited from a randomly sampled cohort of 1,000,000 beneficiaries from the National Health Insurance Research Database. The logistic regression method was employed to estimate the odds ratios (ORs for utilization of CHP. Results. 81.5 percent (N=2,236 of women with breast cancer utilized traditional Chinese medicine (TCM and 18% of them sought TCM with the intent of treating their breast cancer. Jia-wei-xiao-yao-san (Augmented Rambling Powder was the most frequently prescribed formula for treating breast cancer. Among the top 10 most frequently prescribed CHP for treating breast cancer, seven contained dang qui (Angelica sinensis-radix and six contained ren shen (Panax ginseng-radix, which are reported to have potential beneficial synergistic effects on breast cancer cells. Conclusion. CHP containing dang qui (Angelica sinensis-radix or ren shen (Panax ginseng-radix are the most frequently prescribed for breast cancer and their effects should be taken into account by healthcare providers.

  4. Opportunities to Fast-Track Chinese Herbal Therapies into Clinical Practice Through Research Networks

    Institute of Scientific and Technical Information of China (English)

    Stephen M. Sagar

    2008-01-01

    @@ Chinese herbal therapies provide new opportunities to treat cancer and reduce adverse events at multiple chemical,molecular, and physiological levels. Chinese medicine incorporates the notion of 'biosemiosis.' This emphasizes biology considered from the perspectives of signs conveyed and interpreted in a variety of ways,through systems at the macroscopic and microscopic levels, including the communication of singns and meaning between molecules.

  5. Data mining and frequency analysis for licorice as a "Two-Face" herb in Chinese Formulae based on Chinese Formulae Database.

    Science.gov (United States)

    Guo, Jianming; Shang, Erxin; Zhao, Jinlong; Fan, Xinsheng; Duan, Jinao; Qian, Dawei; Tao, Weiwei; Tang, Yuping

    2014-09-25

    Liquorice is the root of Glycyrrhiza uralensis Fisch. or Glycyrrhiza glabra L., Leguminosae. Licorice is described as 'National Venerable Master' in Chinese medicine and plays paradoxical roles, i.e. detoxification/strengthen efficacy and inducing/enhancing toxicity. Therefore, licorice was called "Two-Face" herb in this paper. The aim of this study is to discuss the paradoxical roles and the perspective usage of this "Two-Face" herb using data mining and frequency analysis. More than 96,000 prescriptions from Chinese Formulae Database were selected. The frequency and the prescription patterns were analyzed using Microsoft SQL Server 2000. Data mining methods (frequent itemsets) were used to analyze the regular patterns and compatibility laws of the constituent herbs in the selected prescriptions. The result showed that licorice (Radix glycyrrhizae) was the most frequently used herb in Chinese Formulae Database, other frequently used herbs including Radix Angelicae Sinensis (Dang gui), Radix et rhizoma ginseng (Ren shen), etc. Toxic herbs such as Radix aconiti lateralis praeparata (Fu zi), Rhizoma pinelliae (Ban xia) and Cinnabaris (Zhu sha) are top 3 herbs that most frequently used in combination with licorice. Radix et rhizoma ginseng (Ren shen), Poria (Fu ling), Radix Angelicae Sinensis (Dang gui) are top 3 nontoxic herbs that most frequently used in combination with licorice. Moreover, Licorice was seldom used with sargassum (Hai Zao), Herba Cirsii Japonici (Da Ji), Euphorbia kansui (Gan Sui) and Flos genkwa (Yuan Hua), which proved the description of contradictory effect of Radix glycyrrhizae and these herbs as recorded in Chinese medicine theory. This study showed the principle pattern of Chinese herbal drugs used in combination with licorice or not. The principle patterns and special compatibility laws reported here could be useful and instructive for scientific usage of licorice in clinic application. Further pharmacological and chemical researches are

  6. The chronic hepatotoxicity assessment of the herbal formula Zishen Yutai pill.

    Science.gov (United States)

    Xing, Xiaoyan; Deng, Xuehong; Shi, Jinjin; Zhang, Meishuang; Sun, Guibo; Tang, Shimin; Huang, Qiuling; Sun, Xiaobo

    2017-02-01

    Zishen Yutai pill (ZYP) is an oriental herbal formula, while hepatotoxicity assessment of ZYP was rarely evaluated. Therefore, our aim is to re-evaluate its hepatotoxicity in both normal and carbon tetrachloride (CCl4) induced chronic liver injury rats. In the normal model, two doses of ZYP (1.575 and 9.450 g kg(-1) d(-1); i.e. 1 × , 6 × clinical doses) were given orally to rats for 24 weeks. In the chronic liver injury model, 10% CCl4 was administered to rats abdominally twice a week at a dose of 5 mL kg(-1) for 12 consecutive weeks. Administration time started from 4 weeks after the beginning of CCl4 treatment. Toxicological parameters included mortality, body weight, food consumption, clinical signs, biochemical parameters, gross observation, organ weight, necropsy findings and histopathology were monitored. In the normal model, we found no any mortality or abnormality in clinical signs, relative liver weight, biochemical parameters and histopathology in ZYP treatment groups. In the chronic liver injury model, liver damage related parameter such as ALT was elevated at the high dose of ZYP treatment in contrast to the CCl4-treated group (P rats and 9.450 g kg(-1) d(-1) ZYP in the injury rats.

  7. Traditional Herbal Formula Oyaksungi-San Inhibits Adipogenesis in 3T3-L1 Adipocytes

    Directory of Open Access Journals (Sweden)

    Sae-Rom Yoo

    2015-01-01

    Full Text Available Background. Oyaksungi-san (OYSGS is a herbal formula that has been used for treating cardiovascular diseases in traditional Asian medicine. Here, we investigated the antiadipogenic effect of OYSGS extract in 3T3-L1 adipose cells. Methods. 3T3-L1 preadipocytes were differentiated into adipocytes with or without OYSGS. After differentiation, we measured Oil Red O staining, glycerol-3-phosphate dehydrogenase (GPDH activity, leptin production, mRNA, and protein levels of adipogenesis-related factors. Results. OYSGS extract dramatically inhibited intracellular lipid accumulation in the differentiated adipocytes. It also significantly suppressed the (GPDH activity, triglyceride (TG content, and leptin production by reducing the expression of adipogenesis-related genes including lipoprotein lipase, fatty acid binding protein 4, CCAAT/enhancer-binding protein-alpha (C/EBP-α, and peroxisome proliferator-activated receptor gamma (PPAR-γ. Furthermore, OYSGS clearly enhanced phosphorylation of AMP-activated protein kinase (AMPK as well as its substrate acetyl CoA (ACC carboxylase. Conclusions. Our results demonstrate that OYSGS negatively controls TG accumulation in 3T3-L1 adipocytes. We suggest antiadipogenic activity of OYSGS and its potential benefit in preventing obesity.

  8. Thirty-two Cases of Vascular Headache Treated by Acupuncture Combined with Chinese Herbal Decoction

    Institute of Scientific and Technical Information of China (English)

    HE Qing-yong; LIANG Jun; ZHANG Yue; ZHANG Ji; CHEN Zheng-qiu

    2009-01-01

    Objective: To compare the acupuncture plus oral administration of Chinese herbal decoction with simple oral administration of Chinese herbal decoction in the treatment of vascular headache. Methods: Sixty two patients were randomly divided into a treatment group (32 cases) and a control group (30 cases). Acupuncture at Baihui (GV 20), Fengchi (GB 20), Shuaigu (GB 8), Xingjian (LR 2), Neiguan (PC 6), Sanyinjiao (SP 6) and Ashi points combined with oral administration of Chinese herbal decoction, was applied in the treatment group, and simple oral administration of Chinese herbal decoction was applied in the control group. Results: The total therapeutic effect in the treatment group was better than that in the control group (P<0.05). After treatment, the frequency, and duration of the attacks were reduced and shortened, and headache greatly alleviated in both groups (P<0.01). The alleviation in the treatment group was more obvious than that in the control group (P<0.05). Conclusion: Acupuncture combined with oral administration of Chinese herbal decoction provided remarkable therapeutic effects in treating vascular headache.

  9. Positive Drug Screen for Benzodiazepine Due to a Chinese Herbal Product

    OpenAIRE

    Eachus, Patricia L.

    1996-01-01

    A female athlete tested positive for benzodiazepine on a random drug screen. She denied taking any illicit or prescription drugs. The positive screen was found to be caused by undeclared addiction of diazepam to a Chinese herbal product, “Miracle Herb.” Some foreign vitamins, health care products, or herbal tea may contain banned or dangerous additives unknown to the consumer. These additives may include ingredients such as benzodiazepine, mefenamic acid, or corticosteroids. Possible physical...

  10. Scope of claim coverage in patents of fufang Chinese herbal drugs: Substitution of ingredients

    Directory of Open Access Journals (Sweden)

    Tian Jiaher

    2011-08-01

    Full Text Available Abstract Herbal ingredients in a Chinese fufang prescription are often replaced by one or several other herbal combinations. As there have been very few Chinese herbal patent infringement cases, it is still unclear how the Doctrine of Equivalents should be applied to determine the scope of 'equivalents' in Chinese fufang prescriptions. Case law principles from cases in other technical areas such as chemical patents and biological drug patents can be borrowed to ascertain a precise scope of a fufang patent. This article summarizes and discusses several chemical and biopharmaceutical patent cases. In cases where a certain herbal ingredient is substituted by another herb or a combination of herbs, accused infringers are likely to relate herbal drug patents to chemical drug patents with strict interpretation whereas patent owners may take advantage of the liberal application of Doctrine of Equivalence in biopharmaceutical patents by analogizing the complex nature of herbal drugs with biological drugs. Therefore, consideration should be given to the purpose of an ingredient in a patent, the qualities when combined with the other ingredients and the intended function. The scope of equivalents also depends on the stage of the prior art. Moreover, it is desirable to disclose any potential substitutes when drafting the application. Claims should be drafted in such a way that all foreseeable modifications are encompassed for the protection of the patent owner's intellectual property.

  11. Clinical Observation of Chinese Herbal Fumigation plus Mulberry Stick Beating for Heel Pain

    Institute of Scientific and Technical Information of China (English)

    Shen Qing-he; Shen Zhi-fang; Yan Yu-qin; Zhu Gao-feng

    2014-01-01

    Objective:To observe the clinical efficacy of Chinese herbal fumigation plus beating with mulberry stick in treating heel pain. Methods: Sixty patients with heel pain were randomized into a treatment group and a control group, 30 in each group. The treatment group was intervened by Chinese herbal fumigation plus beating with mulberry stick, and the control group was by orally taking Diclofenac Sodium Sustained Release Tablets plus external use of She Xiang Zhen Tong Gao (Moschus Analgesic Plaster). After one treatment course, the visual analogue scale (VAS) was used to observe the change of pain, and the clinical efficacies were also evaluated. Results: After intervention, the improvement of VAS score in the treatment group was more significant than that in the control group (P Conclusion:Chinese herbal fumigation plus beating with mulberry stick can produce a higher clinical efficacy than orally taking Diclofenac Sodium Sustained Release Tablets in treating heel pain.

  12. Roles of Chinese herbal medicines in ischemic heart diseases (IHD) by regulating oxidative stress.

    Science.gov (United States)

    Wang, Dawei; Wang, Jin; Liu, Yuntao; Zhao, Zhen; Liu, Qing

    2016-10-01

    Ischemic heart disease (IHD) basing on atherosclerosis (AS) is known as a top killer for decades. Oxidative stress, representing excessive oxidation and insufficient elimination, has been proved to be a critical molecular mechanism of IHD and accompanying myocardium dysfunction. Therefore, anti-oxidation therapy may be efficient. Chinese herbal medicine, including extractive compounds, decoctions, patent drugs, and injections, has shown its enormous potential in prevention and treatment of IHD as an effective antioxidant in experimental studies. The aim of this review is to highlight recent studies of Chinese herbal medicine in regulating oxidative stress in IHD. These studies represent recent progress of IHD treatment and indicate the possible pathways and target spots of Chinese herbal medicine.

  13. Treatment of Idiopathic Parkinson's Disease with Traditional Chinese Herbal Medicine: A Randomized Placebo-Controlled Pilot Clinical Study

    Directory of Open Access Journals (Sweden)

    Wan Fung Kum

    2011-01-01

    Full Text Available The objective of this clinical study is to examine the effects of a Chinese herbal medicine formula (Jia Wei Liu Jun Zi Tang: JWLJZT on motor and non-motor symptoms, and on complications of conventional therapy in idiopathic Parkinson's disease (PD, using an add-on design. Fifty-five patients with PD were randomly allocated to receive either Chinese herbal medicine or placebo for 24 weeks. Primary outcome measure was the 39-item Parkinson's Disease Questionnaire (PDQ-39. Secondary outcome measures included the Unified Parkinson's Disease Rating Scale (UPDRS, Short-Form-36 Health Survey (SF-36, Geriatric Depression Scale (GDS, home diaries, and a range of category rating scales. JWLJZT resulted in a significant improvement in the UPDRS IVC when compared with placebo at 12 weeks (P = .039 and 24 weeks (P = .034. In addition, patients in the Chinese herbal medicine group also showed significant improvement in PDQ-39 communication scores at 12 weeks (P = .024 and 24 weeks (P = .047 when compared with the placebo group. There were no significant differences between treatment and control groups for SF-36 variables, GDS score or the mean daily “on-off” time. One case of mild diarrhea was noted in the treatment group. The findings suggest that JWLJZT can relieve some non-motor complications of conventional therapy and improve the communication ability in patients with PD. The results of this pilot study warrant larger multi-center clinical studies to assess long-term efficacy and tolerability of JWLJZT, and to elucidate the mechanisms by which it affects PD function.

  14. Integrated Development of Chinese Herbal Medicine Planting and Tourist Commodities: A Case Study of Green Handmade Soap Development in Shandong Province

    Institute of Scientific and Technical Information of China (English)

    Xiu; LI; Mengxuan; CHEN; Xiaoli; SONG

    2015-01-01

    Combining current situations of Chinese herbal medicine planting industry in Shandong,in line with existing problems of Chinese herbal medicine planting industry,this paper analyzed development prospect of tourist commodity industry in Shandong Province,and came up with actual selection and recommendations for integrated development of Chinese herbal medicine planting and tourist commodities.

  15. The effect of herbal formula PROVE 1 and Stevia levels in diets on diet utilization of growing pigs

    Directory of Open Access Journals (Sweden)

    Kooprasert, S.

    2007-05-01

    Full Text Available The objective of this experiment was to study the effect of 0.2% antibiotic (ascomix-s®, one kilogram of which contains lincomycin hydrochloride 44 g and sulfamethazine 110 g or 0.25% herbal formulaPROVE 1, combined with five levels of Stevia supplementation in the diets on digestibility of pigs. Two factors; 1 type of drug (0.2% antibiotic and 0.25% herbal formula PROVE 1 and 2 five Stevia levels (0,0.2, 0.4, 0.6 and 0.8% were investigated and 10 dietary treatments were used in this study. Ten related growing crossbred (Large White x Landrace barrow pigs (30±1.5 kg body weight were raised in individualmetabolism cages for three collecting periods (30, 40 and 50 kg body weight, each pig was fed one experimental diet throughout the collecting period.The results showed that pigs fed diet with either 0.2% antibiotic or 0.25% herbal formula PROVE 1 had similar digestibility of diet, crude protein (CP, fiber, ash and nitrogen free extract (NFE (89.01 vs 87.83,94.96 vs 94.23, 60.73 vs 59.03, 61.22 vs 60.44 and 93.28 vs 92.03%, respectively. Negligible differences were observed between 0 and 0.4% Stevia supplementation in diet, but levels showed better digestibility than the other levels of Stevia supplementation, and the diet with 0.4% Stevia supplementation had the highestdigestibility of diet, CP, fiber, ash and NFE (91.04, 96.43, 69.48, 70.47 and 94.07%, respectively. The diet with antibiotic combined with 0.4% Stevia had digestibility of diet, CP, fat and fiber better than the otherlevels of Stevia supplementation, especially digestibility of ash, which was significantly higher than that of diet with 0.2% Stevia, but not significantly different from the other levels of Stevia supplementation. A partof herbal formula PROVE1 combined with 0% Stevia had the highest digestibility of ash (72.90%, significantly higher than the other levels of Stevia supplementation, except the diet with herbal formula PROVE 1combined with 0.4% Stevia supplementation

  16. Flavonoid profiling of a traditional Chinese medicine formula of Huangqin Tang using high performance liquid chromatography

    Science.gov (United States)

    Li, Tao; Zhuang, Shuaixing; Wang, Yiwei; Wang, Yanli; Wang, Weihao; Zhang, Huihui; Chen, Li; Wang, Dunfang; Zhou, Zhongming; Yang, Weipeng

    2016-01-01

    The quality control processes for herbal medicines have been problematic. Flavonoids are the major active components of Huangqin Tang (HQT, a traditional Chinese medicine formula). In this study, we used a combinative method approach consisting of chromatographic fingerprinting (high performance liquid chromatography; HPLC), quantitative methods and a pharmacodynamic evaluation model to analyze the flavonoids of HQT obtained from different sources. Ten batches of HQT were analyzed by the HPLC fingerprinting method and 26 common peaks were detected, of which 23 peaks corresponded with the chemical profile of HQT. In addition, 11 major compounds were identified by LC–MS analysis (liquid chromatography–tandem mass spectrometer; LC–MSn) and quantified by the HPLC quantitative method approach. The studied 10 batches of HQT were found to be homogeneous in their composition with a similarity between 0.990 and 1.000. The distribution of the 11 identified compounds was found to be very similar among the batches. Only slight pharmacodynamic differences were detected between the different batches, confirming the homogeneity of HQT. The results of this study prove that the combination of chromatographic fingerprinting and quantitative analysis can be readily used for comprehensive quality control of herbal medicines. PMID:27006899

  17. 6-month evaluation of JinHuang Chinese herbal medicine study in asymptomatic HIV infected Thais.

    Science.gov (United States)

    Maek-a-nantawat, Wirach; Pitisuttithum, Punnee; Bussaratid, Valai; Chamnachanan, Supat; Naksrisook, Supa; Peonim, Wantanee; Thantamnu, Narumon; Muanaum, Rungrapat; Ngamdee, Vatcharachai

    2003-06-01

    Good results of in vitro study of anti-HIV effects of JinHuang, a Chinese herbal medicine led to in vivo study of safety and efficacy among asymptomatic HIV infected individuals. It was a prospective open study of 21 asymptomatic HIV infected Thai volunteers. Twelve and 9 were female and male, respectively, with mean age of 29.24 +/- 3.94 years. JinHuang preparation, 6 capsules and 2 bottles of liquid formula orally three times a day, was given on an outpatient basis initially for 6 months. Regular close monitoring and follow-up were done. The side effects reported included : increased bowel movements (81%), vague taste, and smell of drug after initiation (52%). No serious adverse event related to JinHuang was detected during study. No significant changes in terms of log viral load and CD4 count were observed after 6-months' duration. Most of the patients felt that the quality of life was better in terms of better appetite, good sleep and healthy during study participation, however, these were subjective.

  18. Influence of Chinese Herbal Compound Formula Immunopotentiator Active Ingredient on Partial Physiological Parameters of Pregnancy Mouse%中药复方免疫增强剂有效成分对小白鼠部分生理指标的影响

    Institute of Scientific and Technical Information of China (English)

    李富煌; 白文军; 倪和民; 何高明; 李志远

    2012-01-01

      由熟地、川芎、何首乌等中药组成的中药复方免疫增强剂,经临床应用能显著提高动物机体的免疫功能.本实验将该中药复方制剂中提取出来的多糖、甙类、黄酮分别做动物实验,结果表明:多糖组在增质量实验、主要脏器指数的影响实验、巨噬细胞吞噬实验、红白细胞总数计数实验及白细胞分类计数实验中,与对照组相比差异显著(P<0.05),说明多糖是该复方中起免疫增强作用;甙类组在主要脏器指数的影响实验中,部分脏器指数与对照组相比差异显著(P<0.05),说明甙类对机体免疫功能也有一定的影响.%  Chinese herbal medicine-compound immunopotentiator that are composed of rehmannia glutinosa and ligusticum chuanxiong Hort and Tuber Fleeceflower such as Chinese medicine could significantly improve animals' immune function through the clinical application. In this experiment, carbohydrates and glucosides and flavonoid exacted from the chinese herbal medicine compound had done animal experiments respectively, the results showed that polysaccharide group compared with the control group had significant in increasing quality experiment, experiment of influence of main organ index, macrophage phagocytic experiment, red and white cell count and white blood cell count in the experiment(P<0.05). Therefore, the polysaccharide is the compound of immune enhancement effect. Glycosides group compared with the control group had significant difference ( P<0.05 ) in the main organs index of effect experiment, part organ index shows glycoside on immune function to also have certain effect.

  19. Application of microcalorimetry of Escherichia coli growth and discriminant analysis to the quality assessment of a Chinese herbal injection (Yinzhihuang

    Directory of Open Access Journals (Sweden)

    Yongshen Ren

    2012-06-01

    Full Text Available This paper describes a novel approach to the quality control of a Chinese herbal injection based on microcalorimetric determination of its effect on the biothermal active fingerprint (BTAF of Escherichia coli (E. coli growth. Yinzhihuang Injection (YZHI was selected for this proof of concept study. Reference samples of YZHI were collected and compared with test (stressed samples prepared under different stress conditions. The BTAF of E. coli growth was found to be affected by YZHI and the changes were analyzed on the basis of eleven biothermokinetic parameters. Similarity and multivariate statistical analysis were used to investigate the differences between reference and test samples and discriminant analysis was used to delineate the altered samples. Reference samples were found to have coincident BTAFs with similarity index >0.99. Stressed samples showed differences in the BTAF which increased in line with decreased quality. Discriminant formulae were developed based on a sensitivity parameter which could identify all altered samples. In conclusion, BTAF can be used to assess the quality of YZHI both qualitatively and quantitatively and has the potential to provide a sensitive method for quality control of Chinese herbal injections.

  20. A meta-analysis of Chinese herbal medicines for vascular dementia

    Institute of Scientific and Technical Information of China (English)

    Xiude Qin; Yu Liu; Yanqing Wu; Shuo Wang; Dandan Wang; Jinqiang Zhu; Qiaofeng Ye; Wei Mou; Liyuan Kang

    2013-01-01

    OBJECTIVE: To investigate the efficacy and safety of Chinese herbal medicines in the treatment of patients with vascular dementia.DATA RETRIEVAL: We retrieved publications from Cochrane Library (2004 to July 2011), PubMed (1966 to July 2011), the Chinese Science and Technique Journals Database (1977 to July 2011), the China National Knowledge Infrastructure (1979 to July 2011), Google Scholar (July 2011), and the Chinese Biomedical Database (1977 to July 2011) using the key words "Chinese medicine OR Chinese herbal medicine" and "vascular dementia OR mild cognition impair OR multi-infarct dementia OR small-vessel dementia OR strategic infarct dementia OR hypoperfusion dementia OR hemorrhagic dementia OR hereditary vascular dementia".MAIN OUTCOME MEASURES: Effective rate, Mini-Mental State Examination scores, Hasegawa Dementia Scale scores, and incidence of adverse reactions.CONCLUSION: Chinese herbal medicine appears to be safer and more effective than control measures in the treatment of vascular dementia. However, the included trials were generally low in quality. More well-designed, high-quality trials are needed to provide better evidence for the assessment of the efficacy and safety of Chinese medicines for vascular dementia.

  1. Reflecting the Steps of Modernization of Chinese Materia Medica from the Papers in Chinese Traditional and Herbal Drugs in 2009

    Institute of Scientific and Technical Information of China (English)

    LIU Yan-ze; DAN Yang; PENG Yong; XIAO Pei-gen

    2010-01-01

    The papers in the journal of Chinese Traditional and Herbal Drugs in Vol.40,2009 are briefly reviewed in thecategories of chemical constituents,preparations and technologies,analysis and quality control,pharmacologicaland clinical studies,reviews,and finally healthy principles.Some comments,especially for hot topics have beenpersonally provided.

  2. Prescriptions of Chinese Herbal Medicines for Insomnia in Taiwan during 2002

    OpenAIRE

    Fang-Pey Chen; Maw-Shiou Jong; Yu-Chun Chen; Yen-Ying Kung; Tzeng-Ji Chen; Fun-Jou Chen; Shinn-Jang Hwang

    2011-01-01

    Chinese herbal medicine (CHM) has been commonly used for treating insomnia in Asian countries for centuries. The aim of this study was to conduct a large-scale pharmaco-epidemiologic study and evaluate the frequency and patterns of CHM use in treating insomnia. We obtained the traditional Chinese medicine (TCM) outpatient claims from the National Health Insurance in Taiwan for the year 2002. Patients with insomnia were identified from the diagnostic code of International Classification of Dis...

  3. CLINICAL OBSERVATION ON TREATMENT OF CHRONIC PHARYNGITIS WITH ACUPUNCTURE PLUS CHINESE HERBAL MEDICINES

    Institute of Scientific and Technical Information of China (English)

    聂荣华

    2003-01-01

    @@ Chronic pharyngitis is the diffuse inflammation of the pharyngeal mucus, submucosal and lymph tissues. Traditional Chinese medicine (TCM) considers it to be the category of "Meiheqi" (梅核气,globus hystericus), "Shiyin" (失音,aphonia) and "Houbi" (喉痹,inflammation of the throat). According to the theory of TCM, the author of the present paper adopted acupuncture plus Chinese herbal medicines to treat it from 1990 to 2002, and achieved a satisfactory result. It is reported as follows.

  4. [Discussing of influence mechanism of Chinese herbal monomer on physical stability of cream].

    Science.gov (United States)

    Yin, Hui-Fu; Nie, He-Yun; Wang, Sen; Zhu, Wei-Feng; Li, Rong-Miao

    2014-10-01

    This study left flavonoids and alkaloids Chinese herbal monomer with common parent nucleus as cream base carriages drug respectively, cream base were prepared with stable span 60-tween 80 emulsification system. The near-infrared stability analysis technology was performed to quantitatively characterize the physical stability of cream. Base on the theory of gel network structure, theory of emulsification, theory of solubility parameter and theory of double layer, the influence mechanism of Chinese herbal monomer on physical stability of cream was discussed. The results showed that tetrahydropalmatine, matrine and naringenin had similar solubility parameter value with cream base material, creams prepared with those Chinese herbal monomer have higher Zeta potential value and stronger physical stability, and that those creams had similar microstructure information with cream base. However, a larger solubility parameter difference exists between baicalin, baicalein, berberine, palmatine and cream base material. Creams prepared with those Chinese herbal monomers had lower Zeta potential value and poorer physical stability, and that those creams had great different microstructure information with cream base.

  5. Clinical Observation on Treatment of Acute Eczema by Wet Compress with Chinese Herbal Medicine

    Institute of Scientific and Technical Information of China (English)

    高峰

    2002-01-01

    @@ From April 1999 to Febuary 2001, a compara-tive observation on treatment of acute eczema bylocal wet compress with Chinese herbal medicineand local application of 3 % boric acid solution wascarried out in the author's hospital, and the resultwas reported as follows.

  6. Study on the mechanism of regulation on peritoneal lymphatic stomata with Chinese herbal medicine

    OpenAIRE

    Ding, Shi-Ping; Li, Ji-Cheng; Xu, Jian; Mao, Lian-Gen

    2002-01-01

    AIM: To study the mechanism of Chinese herbal medicine (CHM, the prescription consists of Radix Salviae Miltiorrhizae, Radix Codonopsitis Pilosulae, Rhizoma Atractylodis Alba and Rhizoma Alismatis, Leonurus Heterophyllus Sweet, etc) on the regulation of the peritoneal lymphatic stomata and the ascites drainage.

  7. Acute hepatitis in a patient using a Chinese herbal tea - a case report

    NARCIS (Netherlands)

    Levi, M; Guchelaar, HJ; Woerdenbag, HJ

    1998-01-01

    A case is presented of reversible acute hepatitis in a patient using a Chinese herbal tea. Upon identification of the tea mixture Aristolochia species, including A. debilis, which contains the highly toxic aristolochic acid, could be identified. We conclude that the acute hepatitis as described in t

  8. Chinese herbal medicine and acupuncture for the treatment of cardiovascular disease

    Institute of Scientific and Technical Information of China (English)

    Jun Xu; Haiyun Wu

    2009-01-01

    @@ Traditional Chinese medicine (TCM) is one of the world's oldest healing systems. TCM includes herbal medicine, acupuncture, moxibustion, massage, food therapy, and physical exercise, such as shadow boxing. In modern China, TCM is a fully institutionalised part of health care and widely used with Western medicine.

  9. Efficacy and safety of Chinese herbal medicine for benign prostatic hyperplasia: systematic review of randomized controlled trials

    Institute of Scientific and Technical Information of China (English)

    Chun Ho Ma; Wai Ling Lin; Sing Leung Lui; Xun-Yuan Cai; Vivian Taam Wong; Eric Ziea; Zhang-Jin Zhang

    2013-01-01

    Chinese herbal medicine is commonly used as a treatment for benign prostatic hyperplasia (BPH),but its efficacy and safety remain to be examined.To compare the efficacy and adverse events of Chinese herbal medicine alone or used adjuvantly with Western medications for BPH.Two independent reviewers searched the major electronic databases for randomized controlled trials comparing Chinese herbal medicine,either in single or adjuvant use with Western medication,with placebo or Western medication.Relevant journals and grey literature were also hand-searched.The outcome measures included changes in urological symptoms,urodynamic measures,prostate volume and adverse events.The frequency of commonly used herbs was also identified.Out of 13 922 identified citations of publications,31 studies were included.Eleven studies with a Jadad score ≥ 3 were selected for meta-analysis.Chinese herbal medicine was superior to Western medication in improving quality of life and reducing prostate volume.The frequency of adverse events in Chinese herbal medicine was similar to that of placebo and less than that of Western medication.The evidence is too weak to support the efficacy of Chinese herbal medicine for BPH due to the poor methodological quality and small number of trials included.The commonly used herbs identified here should provide insights for future clinical practice and research.Larger randomized controlled trials of better quality are needed to truly evaluate the efficacy of Chinese herbal medicine.

  10. Green Restaurant: An Ancient Touch of Chinese Herbal Food

    Institute of Scientific and Technical Information of China (English)

    Ambra Schillirò

    2010-01-01

    @@ The first time Ⅰ entered the restaurant Green,inside the five-star Radegast Lake View Hotel in Chongwen District of Beijing,I was incredibly surprised.All around were red lights,a room reminiscent of the splendor of ancient China and simply delicious herbal cuisine.

  11. Green Restaurant: An Ancient Touch of Chinese Herbal Food

    Institute of Scientific and Technical Information of China (English)

    Ambra; Schilliro

    2010-01-01

    The first time I entered the restaurant Green, inside the five-star Radegast Lake View Hotel in Chongwen District of Beijing, I was incredibly surprised. All around were red lights, a room reminiscent of the splendor of ancient China and simply delicious herbal cuisine.

  12. [Determination of the contents of trace elements in chinese herbal medicines for treating respiratory system diseases].

    Science.gov (United States)

    Han, Li-Qin; Dong, Shun-Fu; Liu, Jian-Hua

    2008-02-01

    There is an intimate connection between trace elements and body healthiness, trace elements and organism depend on each other, and each trace element exists with certain proportion, which preserve physio-function. If the balance is of maladjustment, diseases may occur or develop. The trace elements were determined in 16 kinds of Chinese herbal medicines by atomic absorption spectrometry. The medicines include lilium brownii, herba houttuyniae, licorice root, radices isatidis seu baphicacanthi, Sehizandra sinensis Bail, Scutellaria baicalensis Georgi, Beimu, Polygonum multiflorum Thunb, Lithospermum officinalel, Rhizoma acori gramjnoi, Pinellia ternate Breit, Salisburia adiantifolia, Lonicera japonica, Radices puerarire, Bupleurum falcatum and Ligusticum wallichii, all of which could be bought on the market. Sixteen kinds of Chinese herbal medicines commonly used to treat respiratroy system diseases in clinic were selected, dried and powdered, completely mixed, 1.000 0 g was weighed accurately with analytical balance, and 3 portions were used for each kind of sample. The atomic absorption spectrometry was used to determine the contents of trace elements (Cu, Zn, Fe, Cr, Ni and Mn), and the content discrepancy of the trace elements in different medicines was observed the results shows that the contents of the trace elements were rich in the 16 kinds of Chinese herbal medicines, there were more contents of Fe, Zn and Mn, but they were different in different medicines. And there were more trace elements in Salisburia adiantifolia, Polygonum multiflorum Thunb, Bupleurum falcatum, Sehizandra sinensis Bail, Pinellia ternate Breit and Lithospermum officinalel, and lower trace elements in Radices puerarire, Rhizoma acori gramjnoi and Radices isatidis seu baphicacanthi. The analytic results provided useful data for using Chinese herbal medicines and provided theoretical basis for studying Chinese herbal medicines theory.

  13. Targeting cancer-related inflammation: Chinese herbal medicine inhibits epithelial-to-mesenchymal transition in pancreatic cancer.

    Directory of Open Access Journals (Sweden)

    Juan Zhang

    Full Text Available Pancreatic cancer is an almost universally fatal disease resulting from early invasion of adjacent structures and metastasis and the lack of an effective treatment modality. Our previous studies have shown that Qingyihuaji Formula (QYHJ, a seven-herb Chinese medicine formula, had significant anti-cancer effects in pancreatic cancer. Here, we examined the effects of QYHJ on pancreatic cancer cell invasion and metastasis and the potential associated mechanism(s. We found that QYHJ inhibited both tumor growth and metastasis in nude mice with human pancreatic cancer cell xenografts. Further study indicated that QYHJ inhibited epithelial-to-mesenchymal transition (EMT, which is characterized by increased E-cadherin expression and decreased vimentin, N-cadherin and Slug expression. Interleukin 6 (IL-6, a pro-inflammatory cytokine produced mainly by macrophages, could promote cancer cell EMT and invasion. In contrast, treatment with QYHJ inhibited cancer-related inflammation in tumors by decreasing infiltration of tumor-associated macrophages and IL-6 production, thus preventing cell invasion and metastasis. These results suggested that the Chinese herbal medicine QYHJ could inhibit pancreatic cancer cell invasion and metastasis in part by reversing tumor-supporting inflammation.

  14. Progress of Research in Treatment of Hyperlipidemia by Monomer or Compound Recipe of Chinese Herbal Medicine

    Institute of Scientific and Technical Information of China (English)

    DOU Xiao-bing; WO Xing-de; FAN Chun-lei

    2008-01-01

    Hyperlipidemia (HLP) is the No.1 risk factor for patients with atherosclerosis (AS) and is directly related to the occurrence of coronary artery disease (CAD) and cerebrovascular disease. Therefore, prevention and treatment of AS is of great importance and of practical significance in controlling the incidence and mortality of CAD. With its peculiar syndrome-dependent therapy, traditional Chinese medicine (TCM) has accumulated abundant practical experiences in this field and good clinical effects have been achieved. Chinese herbal medicine, with its particularly unique advantages and high potentials yet to be tapped, displays its huge strength in HLP prevention and treatment. The progress of studies concerning prevention and treatment of HLP by Chinese herbal medicines, in the form of monomers or compound recipes, is reviewed in this paper.

  15. [Research status on regulation of Chinese herbal compound on intestinal microecology].

    Science.gov (United States)

    Wu, Guo-lin; Yu, Guo-you; Lu, Wen-wen

    2015-09-01

    The ralationship between traditional Chinese medicine (TCM) and intestinal microecology is increasingly being given more and more attention. Combined with the devolopment of intestinal microecology disciplines, effects of TCM on regulation of intestinal microecology have been gradually explained. Both clinical studies and animal experiments have confirmed that TCM can maintain the balance of intestinal microecology and regulate the intestinal flora. The author arrangemented the documents related to Chinese herbal compound adjusting intestinal flora in the recent ten years, summarized that the Chinese herbal compound which can strength spleen and replenish Qi, relax bowels and regulate Qi, dissipate dampness and check diarrhea, clear away heat and toxic materials, promote digestion and relieve stasis had certain regulation effects on intestinal microecology, providing basis for revealing the TCM essence of intestinal microecology.

  16. Traditional Chinese medicine herbal preparations in restless legs syndrome (RLS) treatment: a review and probable first description of RLS in 1529.

    Science.gov (United States)

    Yan, Xue; Wang, Wei-Dong; Walters, Arthur S; Wang, Qi; Liu, Yan-Jiao; Chu, Fu-Yong

    2012-12-01

    Occidental medicine has a given definition for restless legs syndrome (RLS) and knowledge of RLS pathophysiology has led to the development of its therapeutic management. RLS has no cure. Many methods have been used for its treatment, among which traditional Chinese medicine (TCM) has been considered as a new approach. However, description and management of the disease symptoms can be found in Chinese ancient medical systems. The first mention of RLS may have been as early as the third century BC described as "leg uncomfortable". Nonetheless, the lack of a complete description encompassing all four modern cardinal features of RLS makes this uncertain. On the other hand, the first description of RLS encompassing three of the four major modern criteria occurs in the ancient book of Neike Zhaiyao (Internal summary), 1529 AD just about a century and a half prior to the description of RLS by Sir Thomas Willis in England. Here, we introduce the philosophical concepts of traditional Chinese medicine and the description, classification and understanding of RLS symptoms in traditional Chinese medicine. We have conducted an in-depth review of the literature reporting one part of TCM, Chinese herbal treatment efficacy for RLS, through both English and Chinese search engines. Eighty-five studies were included in the review and more than 40 formulas (including 176 different ingredients) were found in the literature. According to the literature, Chinese herbs have been demonstrated to be safe and hold great potential to be an effective treatment modality for RLS, but the evidence is limited by the quality of these studies. Of the eighty-five studies, only nine were clinical trials with a control group and only three of them were randomized. In cases where herbal preparations were compared to Western medications for RLS, the herbal preparations appear to be superior. However, uncertainty as to whether the diagnosis of RLS was made in accord with Western norms and the use of

  17. Safety, clinical and immunologic efficacy of a Chinese herbal medicine (FAHF-2) for food allergy

    Science.gov (United States)

    Wang, Julie; Jones, Stacie M.; Pongracic, Jacqueline A.; Song, Ying; Yang, Nan; Sicherer, Scott H.; Makhija, Melanie M.; Robison, Rachel G.; Moshier, Erin; Godbold, James; Sampson, Hugh A.; Li, Xiu-Min

    2015-01-01

    Background FAHF-2 is a 9-herb formula based on Traditional Chinese Medicine that blocks peanut anaphylaxis in a murine model. In Phase I studies, FAHF-2 was found to be safe, and well tolerated. Objective To evaluate the safety and effectiveness of FAHF-2 as a treatment for food allergy. Methods In this double-blind, randomized, placebo-controlled study, 68 subjects, 12-45 years of age, with allergies to peanut, tree nut, sesame, fish, and/or shellfish, confirmed by baseline double-blind, placebo controlled food challenge (DBPCFC), received FAHF-2 (n=46) or placebo (n=22). After 6 months of therapy, subjects underwent DBPCFC. For those who demonstrated increases in eliciting dose, a repeat DBPCFC was performed 3 months after stopping therapy. Results Treatment was well-tolerated with no serious adverse events. By intent-to-treat analysis, the placebo group had a higher eliciting dose and cumulative dose (p=0.05) at the end of treatment DBPCFC. There was no difference in the requirement for epinephrine to treat reactions (p=0.55). There were no significant differences in allergen-specific IgE and IgG4, cytokine production by PBMCs or basophil activation between active and placebo groups. In vitro immunological studies performed on subject baseline PBMCs incubated with FAHF-2 and food allergen produced significantly less IL-5, greater IL-10 and increased numbers of Tregs than untreated cells. Notably, 44% of subjects had poor drug adherence for at least one-third of the study period. Conclusion FAHF-2 is a safe herbal medication for food allergic individuals and shows favorable in vitro immunomodulatory effects; however, efficacy for improving tolerance to food allergens is not demonstrated at the dose and duration used. PMID:26044855

  18. Positive drug screen for benzodiazepine due to a chinese herbal product.

    Science.gov (United States)

    Eachus, P L

    1996-04-01

    A female athlete tested positive for benzodiazepine on a random drug screen. She denied taking any illicit or prescription drugs. The positive screen was found to be caused by undeclared addiction of diazepam to a Chinese herbal product, "Miracle Herb." Some foreign vitamins, health care products, or herbal tea may contain banned or dangerous additives unknown to the consumer. These additives may include ingredients such as benzodiazepine, mefenamic acid, or corticosteroids. Possible physical harm may result when using products containing these undeclared additives. Team physicians and athletic trainers should educate athletes about the purchase and use of vitamins, herbal teas, and substances that are perceived to be performance-enhancing products, especially those manufactured outside the United States.

  19. The application status of Chinese herbal medicine in military health service in China.

    Science.gov (United States)

    Yang, Ge-Liang; Gu, Wei; Zhang, Hui-Qing; Zhai, Xiao-Feng; Li, Xiao-Qian; Ling, Chang-Quan

    2016-07-01

    Military medicine has had a long history in China since the emergence of the war. Chinese medicine, especially Chinese herbs, was widely used in China as well as other Asian countries for the prevention and treatment of diseases in the military for hundreds of years. However, the use of Chinese medicine in military health service has never been well studied. In this article, we briefly summarize the application status of Chinese herbal medicine in military health service in China, putting particular emphasis on special military environment, in an attempt to build a bridge between Chinese medicine and military health service and promote the quality of health service for the military and maintain world peace.

  20. Oral treatment with herbal formula B307 alleviates cardiac failure in aging R6/2 mice with Huntington’s disease via suppressing oxidative stress, inflammation, and apoptosis

    Directory of Open Access Journals (Sweden)

    Lin CL

    2015-07-01

    Full Text Available Ching-Lung Lin,1 Sheue-Er Wang,2 Chih-Hsiang Hsu,1 Shuenn-Jyi Sheu,3 Chung-Hsin Wu1 1Department of Life Science, National Taiwan Normal University, Taipei, 2Department of Pathological Inspection, Soeurs de Saint Paul de Chartres Medical Corporate Body, Taoyuan City, 3Brion Research Institute of Taiwan, New Taipei City, Taiwan Abstract: Cardiac failure is often observed in aging patients with Huntington’s disease (HD. However, conventional pharmacological treatments for cardiac failure in HD patients have rarely been studied. Chinese herbal medicines, especially combined herbal formulas, have been widely used to treat cardiac dysfunctions over the centuries. Thus, we assess whether oral treatment with herbal formula B307 can alleviate cardiac failure in transgenic mice with HD. After oral B307 or vehicle treatment for 2 weeks, cardiac function and cardiomyocytes in 12-week-old male R6/2 HD mice and their wild-type littermate controls (WT were examined and then compared via echocardiography, immunohistochemistry, and Western blotting. We found that cardiac performance in aging R6/2 HD mice had significantly deteriorated in comparison with their WT (P<0.01. Cardiac expressions of superoxide dismutase 2 (SOD2 and B-cell lymphoma 2 (Bcl-2 in aging R6/2 HD mice were significantly lower than their WT (P<0.01, but cardiac expressions of tumor necrosis factor alpha (TNF-α, neurotrophin-3 (3-NT, 4-hydroxynonenal (4-HNE, Bcl-2-associated X protein (Bax, calpain, caspase 12, caspase 9, and caspase 3 of aging R6/2 HD mice were significantly higher than their WT (P<0.05. Furthermore, we found that cardiac performance in aging R6/2 HD mice had significantly improved under oral B307 treatment (P<0.05. Cardiac expressions of SOD2 and Bcl-2 of aging R6/2 HD mice were significantly higher under oral B307 treatment (P<0.01, but cardiac expressions of TNF-α, 3-NT, 4-HNE, Bax, calpain, caspase 12, caspase 9, and caspase 3 of aging R6/2 HD mice were significantly

  1. A Survey of the Studies on Compatible Law of Ingredients in Chinese Herbal Prescriptions

    Institute of Scientific and Technical Information of China (English)

    Wei Guoli; Zheng Xuebao

    2008-01-01

    @@ To prescribe a Chinese herbal prescription for the patient is the main thing done by the doctor in TCM clinic,and also an important link in TCM difierential treatment.The key point in the study of TCM prescriptions is the compatibility of Jaerbal ingredients in a prescription.To reveal the compatible law of TCM prescriptions is an important component part for TCM modernization.The following is a brief account on this kind of studies.

  2. NINETY-THREE CASES OF GASTROPTOSIS TREATED BY ACUPUNCTURE COMBINED WITH CHINESE HERBAL MEDICINE

    Institute of Scientific and Technical Information of China (English)

    HAN Xin-qiang; HAN Bao-ru; HAN Yan-ru

    2006-01-01

    @@ Gastroptosis refers to prolapse of the stomach to an abnormal position manifested clinically by distending pain below the xiphoid process, hypochondriac fullness, chest stuffiness, abdominal distention and straining sensation,which is mainly caused by reduced tensity, lack of fat of the abdominal wall, relaxed muscles and decreased abdominal pressure. The authors have treated 93 cases of gastroptosis by applying acupuncture combined with Chinese herbal medicine and achieved quite satisfactory therapeutic results reported as follows.

  3. [Applications of mathematical statistics methods on compatibility researches of traditional Chinese medicines formulae].

    Science.gov (United States)

    Mai, Lan-Yin; Li, Yi-Xuan; Chen, Yong; Xie, Zhen; Li, Jie; Zhong, Ming-Yu

    2014-05-01

    The compatibility of traditional Chinese medicines (TCMs) formulae containing enormous information, is a complex component system. Applications of mathematical statistics methods on the compatibility researches of traditional Chinese medicines formulae have great significance for promoting the modernization of traditional Chinese medicines and improving clinical efficacies and optimizations of formulae. As a tool for quantitative analysis, data inference and exploring inherent rules of substances, the mathematical statistics method can be used to reveal the working mechanisms of the compatibility of traditional Chinese medicines formulae in qualitatively and quantitatively. By reviewing studies based on the applications of mathematical statistics methods, this paper were summarized from perspective of dosages optimization, efficacies and changes of chemical components as well as the rules of incompatibility and contraindication of formulae, will provide the references for further studying and revealing the working mechanisms and the connotations of traditional Chinese medicines.

  4. On the Natural Medical Features of Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    Zhu Ming; Gong Jiapei; Liu Yuanlong

    2007-01-01

    @@ Heaven-human-earth Pattern (HHE) regarded as a crucial conception of traditional Chinese medicine (TCM) has been applied extensively in TCM diagnostics, etiology, acupuncture therapeutics, materia medica and herbal formula, etc. It associates closely with Chinese classic cosmology.

  5. Chinese Herbal Medicine in Treatment of Polyhydramnios:a Meta-analysis and Systematic Review

    Institute of Scientific and Technical Information of China (English)

    Fen Zhou; Yu-fang Hao; Yan Chen; Tong Wang

    2013-01-01

    Objective Tocompare the efficacy of Chinese herbal medicine (therapy A) or Chinese herbal medicine plus indomethacin (therapy B) with that of indomethacin alone (therapy C) in treating polyhydramnios.MethodsLiteratures published up toApril 2012 were retrieved from PubMed, Embase and Cochranelibrary, Chinese National Knowledge Infrastructure (CNKI), Chinese Scientific and Technological Periodical Database (VIP), Wangfang, and Traditional Chinese Medicine online.Two researchers collected data independently.The assessment of methodological quality was based on Cochrane handbook and the materials were analyzed with software RevMan 5.1.2. The outcome measure index was relative risk or difference ofmean value (95% confidence interval). The following outcomes were evaluated: (1) general clinical improvement rate; (2) maximum vertical pocket depth; (3) amniotic fluid index (AFI) value; (4) rate of fetalductus arteriosus constriction; (5) incidence of adverse events.ResultsBased on the search strategy, 5 trails involving 1017 patients were finally included. Comparedwith therapy C, therapy A decreased the rate of fetal ductus arteriosus constriction (P<0.01). Therapy B was more effective than therapy C in general clinical improvement and decrease of AFI for polyhydramnios (P<0.01). No serious adverse events were reported in therapy A and therapy B.ConclusionsCompared with therapy C, therapy A and therapy B may appear to be moreeffective for polyhydramnios. However, the exact effectneeds to beconfirmed with well-designedlarge-scale clinical trials.

  6. Antiplatelet effect of active components derived from Chinese herbal medicine.

    Science.gov (United States)

    Zhang, Ying; Ma, Xiao-Juan; Shi, Da-Zhuo

    2015-10-10

    Atherothrombosis is the major cause of acute coronary syndromes and cardiovascular deaths. Platelets participate in the processes of forming and extending atherosclerotic plaques. Therefore, antiplatelet therapy is a milestone in the primary and second prevention of atherothrombotic diseases. Along with the longterm use of antiplatelet agents, the safety and drug resistance has become a big concern in clinic and new drugs possessing higher effectiveness and fewer adverse effects are needed. Abundant recent data support that traditional Chinese herbs may be a good alternative and complementary choice of new antiplatelet drugs. This review highlights the progress of antiplatelet effect of active components derived from traditional Chinese herbs based on their chemical structures.

  7. New Chinese Herbal Product Launched in the US

    Institute of Scientific and Technical Information of China (English)

    Greg; Jones

    2009-01-01

    A new form of Chinese medicine that has dominated the Japanese OTC herb market for decades is now available in the U.S.The new medicines,called"Prime Herbs Granules",are produced through a process involving strict controls and advanced technology at every stage.Nevertheless,consumers agree that the benefits are worth

  8. Chinese Herbal Medicine Image Recognition and Retrieval by Convolutional Neural Network.

    Science.gov (United States)

    Sun, Xin; Qian, Huinan

    2016-01-01

    Chinese herbal medicine image recognition and retrieval have great potential of practical applications. Several previous studies have focused on the recognition with hand-crafted image features, but there are two limitations in them. Firstly, most of these hand-crafted features are low-level image representation, which is easily affected by noise and background. Secondly, the medicine images are very clean without any backgrounds, which makes it difficult to use in practical applications. Therefore, designing high-level image representation for recognition and retrieval in real world medicine images is facing a great challenge. Inspired by the recent progress of deep learning in computer vision, we realize that deep learning methods may provide robust medicine image representation. In this paper, we propose to use the Convolutional Neural Network (CNN) for Chinese herbal medicine image recognition and retrieval. For the recognition problem, we use the softmax loss to optimize the recognition network; then for the retrieval problem, we fine-tune the recognition network by adding a triplet loss to search for the most similar medicine images. To evaluate our method, we construct a public database of herbal medicine images with cluttered backgrounds, which has in total 5523 images with 95 popular Chinese medicine categories. Experimental results show that our method can achieve the average recognition precision of 71% and the average retrieval precision of 53% over all the 95 medicine categories, which are quite promising given the fact that the real world images have multiple pieces of occluded herbal and cluttered backgrounds. Besides, our proposed method achieves the state-of-the-art performance by improving previous studies with a large margin.

  9. Chinese Herbal Medicine Image Recognition and Retrieval by Convolutional Neural Network.

    Directory of Open Access Journals (Sweden)

    Xin Sun

    Full Text Available Chinese herbal medicine image recognition and retrieval have great potential of practical applications. Several previous studies have focused on the recognition with hand-crafted image features, but there are two limitations in them. Firstly, most of these hand-crafted features are low-level image representation, which is easily affected by noise and background. Secondly, the medicine images are very clean without any backgrounds, which makes it difficult to use in practical applications. Therefore, designing high-level image representation for recognition and retrieval in real world medicine images is facing a great challenge. Inspired by the recent progress of deep learning in computer vision, we realize that deep learning methods may provide robust medicine image representation. In this paper, we propose to use the Convolutional Neural Network (CNN for Chinese herbal medicine image recognition and retrieval. For the recognition problem, we use the softmax loss to optimize the recognition network; then for the retrieval problem, we fine-tune the recognition network by adding a triplet loss to search for the most similar medicine images. To evaluate our method, we construct a public database of herbal medicine images with cluttered backgrounds, which has in total 5523 images with 95 popular Chinese medicine categories. Experimental results show that our method can achieve the average recognition precision of 71% and the average retrieval precision of 53% over all the 95 medicine categories, which are quite promising given the fact that the real world images have multiple pieces of occluded herbal and cluttered backgrounds. Besides, our proposed method achieves the state-of-the-art performance by improving previous studies with a large margin.

  10. Study on the mechanism of regulation on peritoneal lymphatic stomata with Chinese herbal medicine

    Institute of Scientific and Technical Information of China (English)

    Shi-Ping Ding; Ji-Cheng Li; Jian Xu; Lian-Gen Mao

    2002-01-01

    AIM: To study the mechanism of Chinese herbal medicine(CHM), the prescription consists of Radix SalviaeMiltiorrhizae , Radix Codonopsitis Pilosulae , RhizornaAtractylodis Alba and Rhizoma Alismatis, LeonurusHeterophyllus Sweet, etc ) on the regulation of theperitoneal lymphatic stomata and the ascites drainage.METHODS: The mouse model of live fibrosis wasestablished with the application of intragastric installationsof carbon tetrachloride once every three days; scanningelectron microscope and computer image processing wereused to detect the area and the distributive density of theperitoneal lymphatic stomata; and the concentrations ofurinary ion and NO in the serum were measured analyzed inthe experiment.RESULTS: Two different doses of CHM could significantlyincrease the area of the peritoneal lymphatic stomata,promote its distribution density and enhance the arainage ofurinary ion such as sodium, potassium and chlorine.Meanwhile, the NO concentration of two different doses ofCHM groups was 133.52 ± 23.57μmol/L, and 137.2 ±26.79μnol/L respectively. In comparison with the controland model groups ( 48.36 ± 6.83μmol/L, and 35.22 ±8.94μmol/L, P < 0.01 ), there existed significantly markeddifference, this made it clear that Chinese herbal medicinecould induce high endogenous NO concentration. The effectof Chinese herbal medicine on the peritoneal lymphaticstomata and the drainage of urinary ion was altered byadding NO donor (sodium nitropurruside, SNP) or NOsynthase (NOS) inhibitor (N(G)-monomethyl-L-arginine, L-NMMA) to the peritoneal cavity.CONCLUSION: There existed correlations between high NOconcentration and enlargement of the peritoneal lymphaticstomata, which result in enhanced drainage of ascites.These data supported the hypothesis that Chinese herbalmedicine could regulate the peritoneal lymphatic stomata byaccelerating the synthesis and release of endogenous NO.

  11. Assessment on Application of Chinese Herbal Medicine in the Process of Corticosterone Reduction in Nephrotic Syndrome

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Objective: To evaluate the effect of Chinese herbal medicine (CHM) in the process of corticosterone (CS) reduction in nephrotic syndrome. Methods: One hundred and twenty patients of idiopathic nephrotic syndrome sensitive to prednisone treatment were divided into two groups randomly. The dosage of prednisone used was conventionally reduced in both groups but CHM herbal treatment was added to the treated group in the period of prednisone reduction. The effect of CHM was estimated by observing the recurrence rate of disease and side-effects of prednisone. Results: The recurrence rate of disease and the occurrence rate of side-effects of prednisone in the treated group were less than those in the control group significantly (P<0.01). Conclusion: Additional CHM in the process of CS reduction in treating CS sensitive nephrotic syndrome could markedly abate the recurrence rate of disease and the side-effect of CS reduction.

  12. Impact of chinese herbal medicine on american society and health care system: perspective and concern.

    Science.gov (United States)

    Lu, Winston I; Lu, Dominic P

    2014-01-01

    Many Americans, not completely satisfied with traditional western medicine, have turned to alternative and complementary medicine which explains the increasing popularity of the herbal products and the Chinese herbal medicine. The lack of government regulations and the increasing advertisements by the manufactures have created an impression to the common public that the natural herbal remedies are inherently safer and cheaper than conventional medicine. The skyrocketing rise of healthcare cost and the adverse reaction and side effects incurred from the prescribed drugs have both reinforced such an impression. Herbs in the USA and in many European countries have been prepared as capsules, tablets, teas, lozenges, juice extracts, tincture, and ointments. Most of the herbs are administered as a single herb in the USA and Europe. However, the traditional Chinese herbal medicine contains multiple active ingredients from various herbs and is prepared as concoctions by simmering them for hours to produce pharma-therapeutic properties useful for the treatment of a particular disease. Those prepared concoctions are taken gingerly with specific treatment purposes. In the USA and some European counties, herbs are distributed and labeled as dietary supplements and are taken by many individuals for a long period of time creating some medical and dental complex problems among them, especially in terms of anesthesia-surgery complications. This paper provides insight into basic differences in how herbs are prepared before administration to the patients in China versus a single unprepared herb sold in the USA and Europe. Also addressed are the interdisciplinary issues with health professionals, the proper regulations for better quality control of imported herbs, and the proper warning on the labels of the herbs.

  13. Are national quality standards for traditional Chinese herbal medicine sufficient? Current governmental regulations for traditional Chinese herbal medicine in certain Western countries and China as the Eastern origin country.

    Science.gov (United States)

    Dobos, G J; Tan, L; Cohen, M H; McIntyre, M; Bauer, R; Li, X; Bensoussan, A

    2005-09-01

    Traditional Chinese herbal Medicine (TCHM) has been gaining interest and acceptance world wide. TCHM provides on the one side promising perspective of scientific interest and on the other side possible health risks if TCHM drugs are not controlled with respect to quality standards or if practitioners for TCHM are not well trained. This paper outlines an introduction to the scientific aspects and potential risks of TCHM therapy followed by a brief, exploratory overview of the current status of TCHM regulations in certain Western countries like the USA, United Kingdom, Germany, Australia and in China as the Eastern origin country of TCHM. Legal foundations to establish quality and safety standards for TCHM crude drugs and ready-made formulas exist in some countries on a local basis but in practice are poorly enforced, where this products have no drug status. In addition practitioners treating patients with TCHM should be well versed in the pharmacology, side effects, and interactions of these substances with Western medicines and should be certified on a regular basis.

  14. Effects of Chinese herbal medicine on plasma glucose, protein and energy metabolism in sheep

    Institute of Scientific and Technical Information of China (English)

    Xi Liang; Kyota Yamazaki; Mohammad Kamruzzaman; Xue Bi; Arvinda Panthee; Hiroaki Sano

    2014-01-01

    Background:The use of antibiotics in animal diets is facing negative feedback due to the hidden danger of drug residues to human health. Traditional Chinese herbal medicine has been used to replace antibiotics in the past two decades and played an increasingly important role in livestock production. The present study was carried out to assess the feeding effects of a traditional nourishing Chinese herbal medicine mixture on kinetics of plasma glucose, protein and energy metabolism in sheep. Ruminal fermentation characteristics were also determined. Methods:Four sheep were fed on either mixed hay (MH-diet) or MH-diet supplemented with 2%of Chinese herbal medicine (mixture of Astragalus root, Angelica root and Atractylodes rhizome;CHM-diet) over two 35-day periods using a crossover design. The turnover rate of plasma glucose was measured with an isotope dilution method using [U-13C]glucose. The rates of plasma leucine turnover and leucine oxidation, whole body protein synthesis (WBPS) and metabolic heat production were measured using the [1-13C]leucine dilution and open circuit calorimetry. Results:Body weight gain of sheep was higher (P=0.03) for CHM-diet than for MH-diet. Rumen pH was lower (P=0.02), concentration of rumen total volatile fatty acid tended to be higher (P=0.05) and acetate was higher (P=0.04) for CHM-diet than for MH-diet. Turnover rates of plasma glucose and leucine did not differ between diets. Oxidation rate of leucine tended to be higher (P=0.06) for CHM-diet than for MH-diet, but the WBPS did not differ between diets. Metabolic heat production tended to be greater (P=0.05) for CHM-diet than for MH-diet. Conclusions:The sheep fed on CHM-diet had a higher body weight gain and showed positive impacts on rumen fermentation and energy metabolism without resulting in any adverse response. Therefore, these results suggested that the Chinese herbal medicine mixture should be considered as a potential feed additive for sheep.

  15. New Effective Treatment of Liver Fibrosis by Chinese Herbal Medicine

    Institute of Scientific and Technical Information of China (English)

    张国梁

    2002-01-01

    @@ Liver fibrosis is an abnormal proliferation pathologic process of intrahepatic fibrous connective tissue that occurs after liver cells have been necrotized and stimulated by inflammatory factors. It is called fibrosis when the pathological change is mild, and liver cirrhosis when the change becomes so severe as to reconstruct the liver lobuli to form pseudolobuli and nodule(1). Liver fibrosis is an important pathological characteristic of chronic hepatopathy and the chief intermediate link to further develop of liver cirrhosis. No ideal remedy for treatment of chronic hepatitic cirrhosis has been found so far. Although some drugs, such as colchicine and penicillamine, had been reported to have the effect of fibrosis inhibition, their clinical application is still limited for the rather severe toxic-side effects. Certain progress have been made from the clinical and experimental studies on anti-fibrosis treatment by traditional Chinese medicine (TCM) carried out widely in China in recent ten years. And here is a general review of the drugs used.

  16. Treatment of cholecystitis with Chinese herbal medicines: A systematic review of the literature

    Institute of Scientific and Technical Information of China (English)

    Zhi-Yong Dong; Guan-Liang Wang; Xing Liu; Jia Liu; De-Zeng Zhu; Chang-Quan Ling

    2012-01-01

    AIM:To analyze the literature on the use of Chinese herbal medicines for the treatment of cholecystitis.METHODS:The literature on treatment of cholecystitis with traditional Chinese medicines (TCM) was analyzed based on the principles and methods described by evidence-based medicine (EBM).Eight databases including MEDLINE,EMbase,Cochrane Central (CCTR),four Chinese databases (China Biological Medicine Database,Chinese National Knowledge Infrastructure Database,Database of Chinese Science and Technology Periodicals,Database of Chinese Ministry of Science and Technology) and Chinese Clinical Registry Center,were searched.Full text articles or abstracts concerning TCM treatment of cholecystitis were selected,categorized according to study design,the strength of evidence,the first author's hospital type,and analyzed statistically.RESULTS:A search of the literature published from 1977 through 2009 yielded 1468 articles in Chinese and 9 in other languages; and 93.92% of the articles focused on clinical studies.No article was of level I evidence,and 9.26% were of level Ⅱ evidence.The literature cited by Science Citation Index (SCI),MEDLINE and core Chinese medical journals accounted for 0.41%,0.68% and 7.29%,respectively.Typically,the articles featured in case reports of illness,examined from the perspective of EBM,were weak in both quality and evidence level,which inconsistently conflicted with the fact that most of the papers were by authors from Level-3 hospitals,the highest possible level evaluated based on their comprehensive quality and academic authenticity in China.CONCLUSION:The published literature on TCM treatment of cholecystitis is of low quality and based on low evidence,and cognitive medicine may functions as a useful supplementary framework for the evaluation.

  17. Effects of Chinese herbal medicine Yiqi Zengmin Formula on expression of glucose transporter 4 in skeletal muscle in type 2 diabetic rats%益气增敏方对2型糖尿病大鼠骨骼肌组织葡萄糖转运蛋白4表达的影响

    Institute of Scientific and Technical Information of China (English)

    薛红丽; 张曾; 王文健; 陈伟华; 应健

    2011-01-01

    Objective: To investigate the effects of traditional Chinese compound recipe Yiqi Zengmin (YQZM) formula on expression of glucose transporter 4 (GLUT4) in skeletal muscle of rats with type 2 diabetes induced by high-fat diet combined with low-dose-streptozotocin injection.Methods: Fifty male rats were randomly divided into two groups: model group fed with high-fat diet (n = 40) and control group (n = 10). After 4-week feed of high-fat diet, the rats of the model group were injected with streptozotocin at a dose of 35 mg/kg. Rats with plasma glucose over 16.67 mmol/L were randomly divided into 4 groups: diabetic model group, YQZM group, rosiglitazone group and losartan group and were treated with water, YQZM, rosiglitazone or losartan respectively by oral administration for 8 weeks. The expression of GLUT4 protein in the cytoplasm and the plasma membrane of isolated rats' skeletal muscles were detected by Western blotting.Results: The expression of GLUT4 in the plasma membrane was more than that in the cytoplasm in skeletal muscle tissues of the normal rats, while the expression of GLUT-4 in the plasma membrane was less than that in the cytoplasm in skeletal muscle tissues of the type 2 diabetic rats. YQZM formula enhanced GLUT4 translocation from the cytoplasm to the plasma membrane in skeletal muscle tissues, similar to rosiglitazone. Conclusion; YQZM formula can enhance GLUT4 translocation from the cytoplasm to the plasma membrane in skeletal muscle tissues, and displays the insulin sensitization characteristic of rosiglitazone.%目的:研究益气增敏方对高脂饮食联合链脲佐菌素( streptozotocin,STZ)诱导的2型糖尿病(type 2 diabetes mellitus,T2DM)大鼠骨骼肌细胞葡萄糖转运蛋白4(glucose transporter 4,GLUT4)表达的影响.方法:采用高脂饮食联合STZ诱导T2DM建立大鼠模型.健康雄性SD大鼠55只,随机分为对照组(10只)和高脂饲料组(45只),4周后高脂饲料组大鼠腹腔注射STZ(35 mg

  18. Traditional Chinese Medicine (TCM and Herbal Hepatotoxicity: RUCAM and the Role of Novel Diagnostic Biomarkers Such as MicroRNAs

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    Rolf Teschke

    2016-07-01

    Full Text Available Background: Traditional Chinese Medicine (TCM with its focus on herbal use is popular and appreciated worldwide with increased tendency, although its therapeutic efficacy is poorly established for most herbal TCM products. Treatment was perceived as fairly safe but discussions emerged more recently as to whether herb induced liver injury (HILI from herbal TCM is a major issue; Methods: To analyze clinical and case characteristics of HILI caused by herbal TCM, we undertook a selective literature search in the PubMed database with the search items Traditional Chinese Medicine, TCM, alone and combined with the terms herbal hepatotoxicity or herb induced liver injury; Results: HILI caused by herbal TCM is rare and similarly to drugs can be caused by an unpredictable idiosyncratic or a predictable intrinsic reaction. Clinical features of liver injury from herbal TCM products are variable, and specific diagnostic biomarkers such as microsomal epoxide hydrolase, pyrrole-protein adducts, metabolomics, and microRNAs are available for only a few TCM herbs. The diagnosis is ascertained if alternative causes are validly excluded and causality levels of probable or highly probable are achieved applying the liver specific RUCAM (Roussel Uclaf Causality Assessment Method as the most commonly used diagnostic tool worldwide. Case evaluation may be confounded by inappropriate or lacking causality assessment, poor herbal product quality, insufficiently documented cases, and failing to exclude alternative causes such as infections by hepatotropic viruses including hepatitis E virus infections; Conclusion: Suspected cases of liver injury from herbal TCM represent major challenges that deserve special clinical and regulatory attention to improve the quality of case evaluations and ascertain patients’ safety and benefit.

  19. A survey of Chinese herbal ingredients with liver protection activities

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    Lien Linda

    2007-05-01

    Full Text Available Abstract A literature survey was conducted on herbs, their preparations and ingredients with reported liver protection activities, in which a total of 274 different species and hundreds of active ingredients have been examined. These ingredients can be roughly classified into two categories according to their activities: (1 the main ingredients, such as silybin, osthole, coumarin, glycyrrhizin, saikosaponin A, schisandrin A, flavonoids; and (2 supporting substances, such as sugars, amino acids, resins, tannins and volatile oil. Among them, some active ingredients have hepatoprotective activities (e.g. anti-inflammatory, anticancer, antioxidant, immunomodulating and liver cirrhosis-regulating effects. Calculation of physicochemical parameters indicates that the main ingredients with negative and positive Elumo values possibly display their hepatoprotective effects through different mechanisms, such as antioxidative, anti-inflammatory and immunomodulating effects. As the combination of herbs may achieve some treatment effects synergistically and/or additively, it is common in Chinese medicine to use mixtures of various medicinal herbs with pharmacologically active compounds to have synergistic and/or additive effects, or to reduce harmful effects of some pharmacologically active compounds. In particular, the active compounds with Clog P around 2 are suitable for passive transport across membranes and accessible to the target sites. Thus, Elumo and Clog P values are good indicators among the calculated parameters. Seven different physicochemical parameters (MW, Clog P, CMR, μ, Ehomo, Elumo and Hf and four major biological activities (antioxidant, anti-inflammatory, antiviral/antitumor and immunomodulating are discussed in this review. It is hoped that the discussion may provide some leads in the development of new hepatoprotective drugs.

  20. Theories and Practice in Prevention and Treatment Principles in Relation to Chinese Herbal Medicine and Bone Loss

    Institute of Scientific and Technical Information of China (English)

    Hong Xu 徐红; David LAWSON

    2004-01-01

    Osteoporosis is a world wide problem that is increasing in significance as the global population both increases and ages. While osteoporosis has been extensively studied in recent years, the utilization of Traditional Chinese Herbal Medicine for the prevention and treatment of this condition have seldom been examined in the Western world. This paper reviews the theories and the literature that relate to prevention and treatment of bone loss at the time of menopause according to the principles of Traditional Chinese Herbal Medicine. Practical developments in these areas are also illustrated in this paper based on the authors' research findings in recent studies.

  1. Effect of Chinese Herbal Medicine Combined with Acitretin Capsule in Treating Psoriasis of Blood-Heat Syndrome Type

    Institute of Scientific and Technical Information of China (English)

    张立新; 白彦萍; 宋佩华; 尤立平; 杨顶权

    2009-01-01

    Objective:To observe the clinical curative effect of Chinese herbal medicine combined with acitretin capsule in treating psoriasis of blood-heat syndrome(P-BH).Methods:Eighty patients of P-BH were randomly assigned to two groups,39 in Group A and 41 in Group B.Both was treated with Chinese herbal medicines for clearing heat,cooling blood and removing toxic substance,and acitretin capsule was given to Group A additionally,with 8 weeks as one therapeutic course.The clinical curative effect was compared bet...

  2. To Set Up a Logistic Regression Prediction Model for Hepatotoxicity of Chinese Herbal Medicines Based on Traditional Chinese Medicine Theory

    Science.gov (United States)

    Liu, Hongjie; Li, Tianhao; Zhan, Sha; Pan, Meilan; Ma, Zhiguo; Li, Chenghua

    2016-01-01

    Aims. To establish a logistic regression (LR) prediction model for hepatotoxicity of Chinese herbal medicines (HMs) based on traditional Chinese medicine (TCM) theory and to provide a statistical basis for predicting hepatotoxicity of HMs. Methods. The correlations of hepatotoxic and nonhepatotoxic Chinese HMs with four properties, five flavors, and channel tropism were analyzed with chi-square test for two-way unordered categorical data. LR prediction model was established and the accuracy of the prediction by this model was evaluated. Results. The hepatotoxic and nonhepatotoxic Chinese HMs were related with four properties (p flavors (p 0.05). There were totally 12 variables from four properties and five flavors for the LR. Four variables, warm and neutral of the four properties and pungent and salty of five flavors, were selected to establish the LR prediction model, with the cutoff value being 0.204. Conclusions. Warm and neutral of the four properties and pungent and salty of five flavors were the variables to affect the hepatotoxicity. Based on such results, the established LR prediction model had some predictive power for hepatotoxicity of Chinese HMs. PMID:27656240

  3. To Set Up a Logistic Regression Prediction Model for Hepatotoxicity of Chinese Herbal Medicines Based on Traditional Chinese Medicine Theory.

    Science.gov (United States)

    Liu, Hongjie; Li, Tianhao; Chen, Lingxiu; Zhan, Sha; Pan, Meilan; Ma, Zhiguo; Li, Chenghua; Zhang, Zhe

    2016-01-01

    Aims. To establish a logistic regression (LR) prediction model for hepatotoxicity of Chinese herbal medicines (HMs) based on traditional Chinese medicine (TCM) theory and to provide a statistical basis for predicting hepatotoxicity of HMs. Methods. The correlations of hepatotoxic and nonhepatotoxic Chinese HMs with four properties, five flavors, and channel tropism were analyzed with chi-square test for two-way unordered categorical data. LR prediction model was established and the accuracy of the prediction by this model was evaluated. Results. The hepatotoxic and nonhepatotoxic Chinese HMs were related with four properties (p 0.05). There were totally 12 variables from four properties and five flavors for the LR. Four variables, warm and neutral of the four properties and pungent and salty of five flavors, were selected to establish the LR prediction model, with the cutoff value being 0.204. Conclusions. Warm and neutral of the four properties and pungent and salty of five flavors were the variables to affect the hepatotoxicity. Based on such results, the established LR prediction model had some predictive power for hepatotoxicity of Chinese HMs.

  4. Inhibitory Effects of Traditional Herbal Formula Pyungwi-San on Inflammatory Response In Vitro and In Vivo

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    Ji Young Cha

    2013-01-01

    Full Text Available Pyungwi-san (PWS is a traditional basic herbal formula. We investigated the effects of PWS on induction of cyclooxygenase-2 (COX-2, inducible nitric oxide synthase (iNOS, pro-inflammatory cytokines (interleukin-6 (IL-6 and tumor necrosis factor-α (TNF-α and nuclear factor-kappa B (NF-κB as well as mitogen-activated protein kinases (MAPKs in lipopolysaccharide-(LPS- induced Raw 264.7 cells and on paw edema in rats. Treatment with PWS (0.5, 0.75, and 1 mg/mL resulted in inhibited levels of expression of LPS-induced COX-2, iNOS, NF-κB, and MAPKs as well as production of prostaglandin E2 (PGE2, nitric oxide (NO, IL-6, and TNF-α induced by LPS. Our results demonstrate that PWS possesses anti-inflammatory activities via decreasing production of pro-inflammatory mediators through suppression of the signaling pathways of NF-κB and MAPKs in LPS-induced macrophage cells. More importantly, results of the carrageenan-(CA- induced paw edema demonstrate an anti-edema effect of PWS. In addition, it is considered that PWS also inhibits the acute edematous inflammations through suppression of mast cell degranulations and inflammatory mediators, including COX-2, iNOS and TNF-α. Thus, our findings may provide scientific evidence to explain the anti-inflammatory properties of PWS in vitro and in vivo.

  5. New Perspectives on Chinese Herbal Medicine (Zhong-Yao Research and Development

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    Si-Yuan Pan

    2011-01-01

    Full Text Available Synthetic chemical drugs, while being efficacious in the clinical management of many diseases, are often associated with undesirable side effects in patients. It is now clear that the need of therapeutic intervention in many clinical conditions cannot be satisfactorily met by synthetic chemical drugs. Since the research and development of new chemical drugs remain time-consuming, capital-intensive and risky, much effort has been put in the search for alternative routes for drug discovery in China. This narrative review illustrates various approaches to the research and drug discovery in Chinese herbal medicine. Although this article focuses on Chinese traditional drugs, it is also conducive to the development of other traditional remedies and innovative drug discovery.

  6. Angiogenesis in Ischemic Stroke and Angiogenic Effects of Chinese Herbal Medicine

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    Sai-Wang Seto

    2016-06-01

    Full Text Available Stroke is one of the major causes of death and adult disability worldwide. The underlying pathophysiology of stroke is highly complicated, consisting of impairments of multiple signalling pathways, and numerous pathological processes such as acidosis, glutamate excitotoxicity, calcium overload, cerebral inflammation and reactive oxygen species (ROS generation. The current treatment for ischemic stroke is limited to thromolytics such as recombinant tissue plasminogen activator (tPA. tPA has a very narrow therapeutic window, making it suitable to only a minority of stroke patients. Hence, there is great urgency to develop new therapies that can protect brain tissue from ischemic damage. Recent studies have shown that new vessel formation after stroke not only replenishes blood flow to the ischemic area of the brain, but also promotes neurogenesis and improves neurological functions in both animal models and patients. Therefore, drugs that can promote angiogenesis after ischemic stroke can provide therapeutic benefits in stroke management. In this regard, Chinese herbal medicine (CHM has a long history in treating stroke and the associated diseases. A number of studies have demonstrated the pro-angiogenic effects of various Chinese herbs and herbal formulations in both in vitro and in vivo settings. In this article, we present a comprehensive review of the current knowledge on angiogenesis in the context of ischemic stroke and discuss the potential use of CHM in stroke management through modulation of angiogenesis.

  7. Fifty Cases of Child Restless Syndrome Treated with the Integrated Method of Chinese Herbal Drugs and Auricular-Plaster Therapy

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ Fifty cases of child restless syndrome were treated with oral administration of Chinese traditional herbal drugs plus auricular-plaster therapy from December 1998 to November 2001, and another 47 cases were treated with oral administration of methylphenidate as controls. The result is reported as follows.

  8. Clinical study on treatment of rectal carcinoma with Chinese herbal medicine and high dose fluorouracil emulsion via rectal infusion.

    Institute of Scientific and Technical Information of China (English)

    王晨光

    1999-01-01

    Objective: To study the clinical significance of rectal infusion of Chinese herbal medicine (CHM) plus high dose fluorouracil emulsion in treating rectal carcinoma. Methods: 86 patients of rectal carcinoma were randomly divided into CHM plus chemotherapy group and single chemotherapy group, and the

  9. Effect of Chinese Herbal Medicine Jinlida Granule in Treatment of Patients with Impaired Glucose Tolerance

    Science.gov (United States)

    Shi, Ya-Lin; Liu, Wen-Juan; Zhang, Xiao-Fang; Su, Wei-Juan; Chen, Ning-Ning; Lu, Shu-Hua; Wang, Li-Ying; Shi, Xiu-Lin; Li, Zhi-Bin; Yang, Shu-Yu

    2016-01-01

    Background: Diabetes mellitus (DM) remains a major health problem worldwide. Several clinical trials have shown the superiority of the Traditional Chinese Medicine in delaying or reversing the development and progression of DM. This study aimed to evaluate the efficacy of Jinlida (JLD) granule, a Chinese herbal recipe, in the treatment of impaired glucose tolerance (IGT) and its effect on the prevention of DM. Methods: Sixty-five IGT patients were randomized to receive one bag of JLD granules three times daily (JLD group, n = 34) or no drug intervention (control group, n = 31) for 12 weeks. Oral glucose tolerance test, glycated hemoglobin A1c (HbA1c), body mass index, blood lipids levels, fasting insulin, and insulin resistance calculated using homeostatic model assessment (HOMA-IR) of all the patients were observed and compared before and after the treatment. Results: Sixty-one participants completed the trial (32 in JLD group and 29 in the control group). There were statistically significant decreases in HbA1c (P < 0.001), 2-h plasma glucose (P < 0.001), and HOMA-IR (P = 0.029) in JLD group compared with the control group after 12 weeks of treatment. After 12 weeks of treatment, two (6.9%) patients returned to normal blood glucose, and five (17.2%) patients turned into DM in control group, while in the JLD group, 14 (43.8%) returned to normal blood glucose and 2 (6.2%) turned into DM. There was a significant difference in the number of subjects who had normal glucose at the end of the study between two groups (P = 0.001). Conclusions: JLD granule effectively improved glucose control, increased the conversion of IGT to normal glucose, and improved the insulin resistance in patients with IGT. This Chinese herbal medicine may have a clinical value for IGT. PMID:27647185

  10. Therapeutic strategies for Parkinson's disease: the ancient meets the future--traditional Chinese herbal medicine, electroacupuncture, gene therapy and stem cells.

    Science.gov (United States)

    Wang, Xuan; Liang, Xi-Bin; Li, Feng-Qiao; Zhou, Hui-Fang; Liu, Xian-Yu; Wang, Jian-Jun; Wang, Xiao-Min

    2008-10-01

    In China, it has been estimated that there are more than 2.0 million people suffering from Parkinson's disease, which is currently becoming one of the most common chronic neurodegenerative disorders during recent years. For many years, scientists have struggled to find new therapeutic approaches for this disease. Since 1994, our research group led by Drs. Ji-Sheng Han and Xiao-Min Wang of Neuroscience Research Institute, Peking University has developed several prospective treatment strategies for the disease. These studies cover the traditional Chinese medicine-herbal formula or acupuncture, and modern technologies such as gene therapy or stem cell replacement therapy, and have achieved some original results. It hopes that these data may be beneficial for the research development and for the future clinical utility for treatment of Parkinson's disease.

  11. Chinese Herbal Medicine (Zi Shen Qing for Mild-to-Moderate Systematic Lupus Erythematosus: A Pilot Prospective, Single-Blinded, Randomized Controlled Study

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    Linda L. D. Zhong

    2013-01-01

    Full Text Available Objective. The aim of this study is to investigate the effectiveness and safety of a Chinese herbal formula Zi Shen Qing (ZSQ in the treatment of systematic lupus erythematosus (SLE in Chinese patients. Methods. A randomized controlled trial was conducted over 12 weeks in 84 Chinese patients who reported total scores of SLE Disease Activity Index-2000 (SLEDAI-2000 was from 5 to 14. The primary outcome was the changes of the SLEDAI-2000. The secondary outcomes included score changes of Chinese Medicine Syndromes (CMS, the changes of steroid dosage, the incidence of disease flare-up and biologic markers. Results. ZSQ significantly reduced SLEDAI-2000, the total scores of CMS in the treatment group compared with the controlled group (P<0.05. Superiority of ZSQ over controlled group was also observed with greater improvement in the withdrawal dosage of corticosteroids and the incidence of disease flare-up (P<0.05. There were no serious adverse events, and safety indices of whole blood counts, renal and liver functions were normal, both before and after the treatment. Conclusion. ZSQ is safe and effective for decreasing SLE disease activity and withdrawal dosage of corticosteroids in the mild to moderate SLE patients with “Deficiency of Qi and Yin” Pattern.

  12. Rapid Detection of Pesticide Residues in Chinese Herbal Medicines by Fourier Transform Infrared Spectroscopy Coupled with Partial Least Squares Regression

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    Tianming Yang

    2016-01-01

    Full Text Available This paper reports a simple, rapid, and effective method for simultaneous detection of cartap (Ca, thiocyclam (Th, and tebufenozide (Te in Chinese herbal medicines including Radix Angelicae Dahuricae and Liquorices using Fourier transform infrared spectroscopy (FT-IR coupled with partial least squares regression (PLSR. The proposed method can handle the intrinsic interferences of herbal samples; satisfactory average recoveries attained from near-infrared (NIR and mid-infrared (MIR PLSR models were 99.0±10.8 and 100.2±1.0% for Ca, 100.2±6.9 and 99.7±2.5% for Th, and 99.1±6.3 and 99.6±1.0% for Te, respectively. Furthermore, some statistical parameters and figures of merit are fully investigated to evaluate the performance of the two models. It was found that both models could give accurate results and only the performance of MIR-PLSR was slightly better than that of NIR-PLSR in the cases suffering from herbal matrix interferences. In conclusion, FT-IR spectroscopy in combination with PLSR has been demonstrated for its application in rapid screening and quantitative analysis of multipesticide residues in Chinese herbal medicines without physical or chemical separation pretreatment step and any spectral processing, which also implies other potential applications such as food and drug safety, herbal plants quality, and environmental evaluation, due to its advantages of nontoxic and nondestructive analysis.

  13. Traditional Chinese medicine formulas for irritable bowel syndrome: from ancient wisdoms to scientific understandings.

    Science.gov (United States)

    Xiao, Hai-Tao; Zhong, Linda; Tsang, Siu-Wai; Lin, Ze-Si; Bian, Zhao-Xiang

    2015-01-01

    Traditional Chinese Medicine (TCM) serves as the most common alternative therapeutic approach for Western medicine and benefits IBS patients globally. Due to the lack of scientific evidence in the past, TCM formulas were not internationally well recognized as promising IBS remedies. In this review, firstly, we present the etiology and therapy of IBS in terms of traditional Chinese medical theory. Secondly, we summarize the clinical randomized controlled trials (RCTs) of TCM formulas for IBS patients that are available in the literature (from 1998 to September 2013), in which 14 RCTs conducted of high quality were discussed in detail. Of the 14 selected trials, 12 of those concluded that TCM formulas provided superior improvement in the global symptoms of IBS patients over the placebo or conventional medicines. As well, all 14 RCTs suggested that TCM formulas have good safety and tolerability. Last but not least, we explore the pharmacological mechanisms of the anti-IBS TCM formulas available in the literature (from 1994 to September, 2013). Collectively, in combating IBS symptoms, most TCM formulas exert multi-targeting actions including the regulation of neurotransmitters and hormones in the enteric nervous system (ENS), modulation of smooth muscle motility in the gastrointestinal (GI) tract, modulation of the hypothalamic-pituitary-adrenal (HPA) axis, attenuation of intestinal inflammation and restoration of intestinal flora, etc. In conclusion, TCM formulas appear to be promising for IBS treatment. This review provides a useful reference for the public in furthering a better understanding and acceptance of TCM formulas as IBS remedies.

  14. Usage analysis of some package of Chinese herbal pieces in our hospital%小包装中药饮片在我院的使用情况分析

    Institute of Scientific and Technical Information of China (English)

    张献敏

    2015-01-01

    Some package of Chinese herbal pieces is the embodiment of specification and quality of Chinese herbal pieces,and improve formula model of traditional Chinese herbal pieces with accurate measurement,and it meets the needs of broad patients,and makes patients to enjoy the high quality service. There are many advantages of small pack-age pieces:improves the drug quality and accuracy rate of adjusting;easy to storage and identify;and controllable quality standardization of Chinese herbal;shelf type deposit and convenient management,but there are also many disadvantages of small package of traditional Chinese herbal pieces:the production cost of traditional Chinese herbal medicine pieces is increasing,pollution is the bad side of packaging material;it is not easy for Chinese medicine;it is not for young pharmacists mastering processing and identification method of traditional Chinese medicine pieces;small package of traditional Chinese herbal pieces in Chinese medicine cabinet for storage is not convenient;Chinese herbal medicine pieces and packaging material interacts.The promotion and development of small package of traditional Chinese medicine pieces is a systems project,the key is the source,it needs coordinated development of many aspects.%中药饮片小包装是中药饮片规格和质量的体现,改进了传统中药饮片的配方模式,计量准确,满足了广大患者的需求,使患者享受到了优质服务。小包装饮片的优点是提高了药品质量和调剂准确率;方便储存,易于识别;中药饮片质量标准的可控;货架式存放,便于管理,但中药饮片小包装也存在很多问题:中药饮片的生产成本增加,包装材料带来污染;不便于中医用药;不便于年轻中药师掌握中药饮片的炮制和鉴别方法;中药饮片小包装在中药橱里储存不方便;中药饮片与包装材料相互影响。中药小包装的推广和发展是一个系统工程,重点在

  15. Chinese Herbal Medicine in Folk Custom%民俗中的中草药略识

    Institute of Scientific and Technical Information of China (English)

    齐敏; 李春芳

    2009-01-01

    There are large amount of Chinese herbal medicine used in folk custom of our country. Most of these medicines are related with hygiene and health care. The usage of these medicine included avoiding dirty, preventing diseases, restoring convalescence, health protection, cosmetology, bathing, and daily effective medical prescription. Folk custom has the characteristics of regionality, consistency, and nationality,ete. Some of traditional Chinese medicine originates from folk custom. Therefore, the research of medicine used in folk custom may help to the development of traditional Chinese medicine.%在我国传统民俗中流传有大量中草药,其用途主要包括辟秽防病、康复保健、美容化妆、服饰佩物、洗浴、日常疗病等.民俗为群体性、倾向性的社会行为,并有地域性、传承性、历史性、民族性等特点,同时中草药中的一部分药物也来源于民俗,研究民俗中的药物可有助于研发中药新药.

  16. Is the yin-yang nature of Chinese herbal medicine equivalent to antioxidation-oxidation?

    Science.gov (United States)

    Szeto, Yim-Tong; Benzie, Iris F F

    2006-12-06

    It has been suggested that yin-yang theory described in traditional Chinese medicine is somewhat equivalent to the modern theory of antioxidant-oxidant balance. Some yin-tonic Chinese herbal medicines possess antioxidant properties. In this context, the DNA protective effect of 12 yin-tonic and 13 yang-tonic herbs were tested using the single cell gel electrophoresis (comet) assay. Lymphocytes from three healthy subjects were pre-incubated with aqueous herb extract, and the comet assay was performed on treated, untreated, challenged and unchallenged cells in parallel, oxidant challenge being induced by 5 min exposure to hydrogen peroxide. Results using this ex vivo cellular assay showed protection by some herbs. Seven out of 12 yin-tonic Chinese herbs demonstrated decreased DNA damage after treatment while 10 out of 13 yang-tonic herbs showed protection. Among 25 herbs tested, rhizome of Ligusticum sinensis Oliv. and aerial part of Artemisia annua L. demonstrated greatest DNA protective effect. Results indicated that the yin nature of herbs may not be necessarily associated with superior antioxidative effect to yang-tonic herbs, at least in terms of DNA protection against oxidant challenge.

  17. An herbal formula, CGX, exerts hepatotherapeutic effects on dimethylnitrosamine-induced chronic liver injury model in rats

    Institute of Scientific and Technical Information of China (English)

    Jang-Woo Shin; Myong-Min Lee; Xiao Ping Hu; Chang-Gue Son; Jin-Young Son; Se-Mi Oh; Seung-Hyun Han; Jing-Hua Wang; Jung-Hyo Cho; Chong-Kwan Cho; Hwa-Seung Yoo; Yeon-Weol Lee

    2006-01-01

    AIM: To evaluate the therapeutic effect of Chunggan extract (CGX), a modified traditional Chinese hepatotherapeutic herbal, on the dimethylnitrosamine (DMN)-induced chronic liver injury model in rats.METHODS: Liver injuries were induced in Wistar rats by injection of DMN (ip, 10 mg/mL per kg) for 3 consecutive days per week for 4 wk. The rats were administered with CGX (po, 100 or 200 mg/kg per day) or distilled water as a control daily for 4 wk starting from the 15th d of the DMN treatment. Biochemical parameters (serum albumin, bilirubin, ALP, AST and ALT), lipid peroxides,hydroxyproline, as well as histological changes in liver tissues were analyzed. In addition, gene expression of TNF-α, TGF-β, TIMP-1, TIMP-2, PDGF-β, and MMP-2, all of which are known to be associated with liver fibrosis,were analyzed using real-time PCR.RESULTS: CGX administration restored the spleen weight to normal after having been increased by DMN treatment.Biochemical analysis of the serum demonstrated that CGX significantly decreased the serum level of ALP (P< 0.05), ALT (P < 0.01), and AST (P < 0.01) that had been elevated by DMN treatment. CGX administration moderately lowered lipid peroxide production and markedly lowered hydroxyproline generation caused by DMN treatment in accordance with histopathological examination. DMN treatment induced a highly upregulated expression of TNF-α, TGF-β, TIMP-1, TIMP-2,PDGF-β, and MMP-2. Of these, the gene expression encoding PDGF-β and MMP-2 was still further enhanced 2 wk after secession of the 4-wk DMN treatment, and was remarkably ameliorated by CGX administration.CONCLUSION: CGX exhibits hepatotherapeutic properties against chronic hepatocellular destruction and consequential liver fibrosis.

  18. Arsenic speciation in Chinese Herbal Medicines and human health implication for inorganic arsenic.

    Science.gov (United States)

    Liu, Xiao-Juan; Zhao, Quan-Li; Sun, Guo-Xin; Williams, Paul; Lu, Xiu-Jun; Cai, Jing-Zhu; Liu, Wen-Ju

    2013-01-01

    Rice and drinking water are recognized as the dominant sources of arsenic (As) for human intake, while little is known about As accumulation and speciation in Chinese Herbal Medicines (CHMs), which have been available for many hundreds of years for the treatment of diseases in both eastern and western cultures. Inorganic arsenic was the predominant species in all of CHMs samples. The levels of inorganic arsenic in CHMs from fields and markets or pharmacies ranged from 63 to 550 ng/g with a mean of 208 ng/g and 94 to 8683 ng/g with a mean of 1092 ng/g, respectively. The highest concentration was found in the Chrysanthemum from pharmacies. It indicates that the risk of inorganic As in CHMs to human health is higher in medicines from markets or pharmacies than that collected directly from fields. Some CHMs may make a considerable contribution to the human intake of inorganic arsenic.

  19. Assessment of the embryotoxicity of four Chinese herbal extracts using the embryonic stem cell test.

    Science.gov (United States)

    Li, Lin-Yan; Cao, Fen-Fang; Su, Zhi-Jian; Zhang, Qi-Hao; Dai, Xiao-Yong; Xiao, Xue; Huang, Ya-Dong; Zheng, Qing; Xu, Hua

    2015-08-01

    Rhizoma Atractylodes macrocephala, Radix Isatidis, Coptis chinensis and Flos Genkwa are common herbal remedies used by pregnant woman in China. In this study, their potential embryotoxicity was assessed using the embryonic stem cell test (EST) and a prediction model. The potential embryotoxicity of the herbs was based on three endpoints: the concentrations of the compounds that inhibited the proliferation of 50% of embryonic stem cells (ESCs) (IC50ES), the concentrations that inhibited 50% of 3T3 cells (IC503T3), and the concentrations that inhibited the differentiation of 50% of ESCs (ID50ES). The results revealed that Rhizoma Atractylodes macrocephala and Radix Isatidis are non-embryotoxic compounds. Coptis chinensis extracts appeared to demonstrated weak embryotoxicity, and Flos Genkwa exhibited strong embryotoxicity. These results may be useful in guiding the clinical use of these herbs and in expanding the application of the EST to the field of traditional Chinese medicine.

  20. Ethical Considerations for Acupuncture and Chinese Herbal Medicine Clinical Trials: A Cross-Cultural Perspective

    Directory of Open Access Journals (Sweden)

    Christopher Zaslawski

    2010-01-01

    Full Text Available Many ethical concerns revolve around the four basic principles of research: merit and integrity, respect for human beings, weighting of risk–benefit and justice. These principles form the basis for any discussion concerning human research ethics and are applicable to all areas of research including acupuncture and Chinese herbal medicine. World Health Organisation document, Guidelines for Clinical Research on Acupuncture, states that ‘consideration should be given to the different value systems that are involved in human rights such as social, cultural and historical issues’ and that ‘further studies should be conducted in relation to ethical issues involved in clinical research on acupuncture’. In addition to outlining the four basic principles, this paper will also examine the effect of Asian culture on Western human research ethics and how this may impact upon issues such as informed consent and weighting of risk–benefit.

  1. Application of Spontaneous Photon Emission in the Growth Ages and Varieties Screening of Fresh Chinese Herbal Medicines

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    Zhao, Xiaolei; Fu, Jialei; Van Wijk, Eduard; Liu, Yanli; Fan, Hua; Zhang, Yufeng

    2017-01-01

    Ultraweak photon emission emitted by all living organisms has been confirmed to be a noninvasive indicator for their physiological and pathological characteristics. In this study, we investigated the characteristics of spontaneous photon emission (SPE) and the contents of specific active compounds of roots and flowers buds of several fresh Chinese herbal medicines (natural medicines) with different growth ages and varieties. The results revealed that the contents of specific active compounds from same species herbs with different growth ages and varieties were significantly different, and this difference could be reflected by their SPE. Because the contents of specific bioactive constituents in Chinese herbs are closely related to their quality and curative effect, the SPE measurement technique may contribute to the quality control of Chinese herbal medicine in the future.

  2. Study on the mechanism of regulation on peritoneal lymphatic stomata with Chinese herbal medicine

    Science.gov (United States)

    Ding, Shi-Ping; Li, Ji-Cheng; Xu, Jian; Mao, Lian-Gen

    2002-01-01

    AIM: To study the mechanism of Chinese herbal medicine (CHM, the prescription consists of Radix Salviae Miltiorrhizae, Radix Codonopsitis Pilosulae, Rhizoma Atractylodis Alba and Rhizoma Alismatis, Leonurus Heterophyllus Sweet, etc) on the regulation of the peritoneal lymphatic stomata and the ascites drainage. METHODS: The mouse model of live fibrosis was established with the application of intragastric installations of carbon tetrachloride once every three days; scanning electron microscope and computer image processing were used to detect the area and the distributive density of the peritoneal lymphatic stomata; and the concentrations of urinary ion and NO in the serum were analyzed in the experiment. RESULTS: Two different doses of CHM could significantly increase the area of the peritoneal lymphatic stomata, promote its distributive density and enhance the drainage of urinary ion such as sodium, potassium and chlorine. Meanwhile, the NO concentration of two different doses of CHM groups was 133.52 ± 23.57 μmol/L, and 137.2 ± 26.79 μmol/L respectively. In comparison with the control group and model groups (48.36 ± 6.83 μmol/L, and 35.22 ± 8.94 μmol/L, P lymphatic stomata and the drainage of urinary ion was altered by adding NO donor(sodium nitropurruside, SNP) or NO synthase (NOS) inhibitor (N(G)-monomethyl-L-arginine, L-NMMA) to the peritoneal cavity. CONCLUSION: There existed correlations between high NO concentration and enlargement of the peritoneal lymphatic stomata, which result in enhanced drainage of ascites. These data supported the hypothesis that Chinese herbal medicine could regulate the peritoneal lymphatic stomata by accelerating the synthesis and release of endogenous NO. PMID:11833101

  3. 四个抗球虫中药复方对肉鸡球虫病疗效对比试验%Efficacy Comparative of Four Chinese Herbal Compounds on Coccidiosis in Broiler Chickens

    Institute of Scientific and Technical Information of China (English)

    郭红斌; 弓素梅; 王凤霞

    2011-01-01

    试验按照中兽医辨证论治的原则,根据鸡球虫病的特点,组成了4个中药方剂.为了比较4个中药复方对内鸡感染柔嫩艾美耳球虫(Eimeria tenella)的治疗效果,通过观察临床症状,测定存活率、相对增重率、病变值、卵囊值等,计算抗球虫指数.结果表明,方剂一的抗球虫指数最高,抗球虫效果较好.%Four Chinese herbal formula were composed according to the characteristics of chicken coccidiosis and based on the rule of syndrome differentiation and treatment of the traditional Chinese veterinary medicine. The efficacy of four Chinese herbal compounds for broiler chickens infected with Eimeria tenella were compared through observing the clinical symptoms,determining survival rate, relative growth rate, cecal lesion score and oocysts value and then calculating the anticoccidial in dex. The results showed that the anticoccidial index of Formula 1 was the highest, and its anticoccidial efficacy was better than others.

  4. Effects of Chinese herbal enema therapy combined basic treatment on BUN,SCr,UA,and IS in chronic renal failure patients

    Institute of Scientific and Technical Information of China (English)

    邹川

    2012-01-01

    Objective To assess the clearance role and safety of Chinese herbal enema therapy (CHET) in clearing enterogenic uremic toxins in chronic renal failure (CRF) patients,thus providing evidence for further optimizing the comprehensive treatment. Methods Using nonrandomized concurrent control

  5. Chinese Massage Combined with Herbal Ointment for Athletes with Nonspecific Low Back Pain: A Randomized Controlled Trial

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    Ling Jun Kong

    2012-01-01

    Full Text Available Non-specific low back pain (NLBP is an increasing health problem for athletes. This randomized controlled trial was designed to investigate the effects of Chinese massage combined with herbal ointment for NLBP. 110 athletes with NLBP were randomly assigned to experimental group with Chinese massage combined with herbal ointment or control group with simple massage therapy. The primary outcome was pain by Chinese Short Form McGill Pain Questionnaire (C-SFMPQ. The secondary outcome was local muscle stiffness by Myotonometer. After 4 weeks, the experimental group experienced significant improvements in C-SFMPQ and in local muscle stiffness compared with control group (between-group difference in mean change from baseline, −1.24 points, P=0.005 in sensory scores; −3.14 points, P<0.001 in affective scores; −4.39 points, P<0.001 in total scores; −0.64 points, P=0.002 in VAS; −1.04 points, P=0.005 in local muscle stiffness during relaxation state. The difference remained at one month followup, but it was only significant in affective scores (−2.83 points, P<0.001 at three months followup. No adverse events were observed. These findings suggest that Chinese massage combined with herbal ointment may be a beneficial complementary and alternative therapy for athletes with NLBP.

  6. Herbal medicines and nonalcoholic fatty liver disease.

    Science.gov (United States)

    Yao, Hong; Qiao, Yu-Jie; Zhao, Ya-Li; Tao, Xu-Feng; Xu, Li-Na; Yin, Lian-Hong; Qi, Yan; Peng, Jin-Yong

    2016-08-14

    Nonalcoholic fatty liver disease (NAFLD), which is characterized by excessive fat accumulation in the liver of patients who consume little or no alcohol, becomes increasingly common with rapid economic development. Long-term excess fat accumulation leads to NAFLD and represents a global health problem with no effective therapeutic approach. NAFLD is considered to be a series of complex, multifaceted pathological processes involving oxidative stress, inflammation, apoptosis, and metabolism. Over the past decades, herbal medicines have garnered growing attention as potential therapeutic agents to prevent and treat NAFLD, due to their high efficacy and low risk of side effects. In this review, we evaluate the use of herbal medicines (including traditional Chinese herbal formulas, crude extracts from medicinal plants, and pure natural products) to treat NAFLD. These herbal medicines are natural resources that can inform innovative drug research and the development of treatments for NAFLD in the future.

  7. Herbal medicines and nonalcoholic fatty liver disease

    Science.gov (United States)

    Yao, Hong; Qiao, Yu-Jie; Zhao, Ya-Li; Tao, Xu-Feng; Xu, Li-Na; Yin, Lian-Hong; Qi, Yan; Peng, Jin-Yong

    2016-01-01

    Nonalcoholic fatty liver disease (NAFLD), which is characterized by excessive fat accumulation in the liver of patients who consume little or no alcohol, becomes increasingly common with rapid economic development. Long-term excess fat accumulation leads to NAFLD and represents a global health problem with no effective therapeutic approach. NAFLD is considered to be a series of complex, multifaceted pathological processes involving oxidative stress, inflammation, apoptosis, and metabolism. Over the past decades, herbal medicines have garnered growing attention as potential therapeutic agents to prevent and treat NAFLD, due to their high efficacy and low risk of side effects. In this review, we evaluate the use of herbal medicines (including traditional Chinese herbal formulas, crude extracts from medicinal plants, and pure natural products) to treat NAFLD. These herbal medicines are natural resources that can inform innovative drug research and the development of treatments for NAFLD in the future. PMID:27570425

  8. Effect of Chinese Herbal Medicine Jinlida Granule in Treatment of Patients with Impaired Glucose Tolerance

    Institute of Scientific and Technical Information of China (English)

    Ya-Lin Shi; Wen-Juan Liu; Xiao-Fang Zhang; Wei-Juan Su; Ning-Ning Chen; Shu-Hua Lu; Li-Ying Wang

    2016-01-01

    Background:Diabetes mellitus (DM) remains a major health problem worldwide.Several clinical trials have shown the superiority of the Traditional Chinese Medicine in delaying or reversing the development and progression of DM.This study aimed to evaluate the efficacy of Jinlida (JLD) granule,a Chinese herbal recipe,in the treatment of impaired glucose tolerance (IGT) and its effect on the prevention of DM.Methods:Sixty-five IGT patients were randomized to receive one bag of JLD granules three times daily (JLD group,n =34) or no drug intervention (control group,n =31) for 12 weeks.Oral glucose tolerance test,glycated hemoglobin A1c (HbA1c),body mass index,blood lipids levels,fasting insulin,and insulin resistance calculated using homeostatic model assessment (HOMA-IR) of all the patients were observed and compared before and after the treatment.Results:Sixty-one participants completed the trial (32 in JLD group and 29 in the control group).There were statistically significant decreases in HbA1c (P < 0.001),2-h plasma glucose (P < 0.001),and HOMA-IR (P =0.029) in JLD group compared with the control group after 12 weeks of treatment.After 12 weeks of treatment,two (6.9%) patients returned to normal blood glucose,and five (17.2%) patients turned into DM in control group,while in the JLD group,14 (43.8%) returned to normal blood glucose and 2 (6.2%) turned into DM.There was a significant difference in the number of subjects who had normal glucose at the end of the study between two groups (P =0.001).Conclusions:JLD granule effectively improved glucose control,increased the conversion of IGT to normal glucose,and improved the insulin resistance in patients with IGT.This Chinese herbal medicine may have a clinical value for IGT.

  9. Novel medical bathing with traditional Chinese herb formula alleviates paraplegia spasticity.

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    Liu, Xin; Meng, Qingxi; Yu, Dapeng; Zhao, Xiwu; Zhao, Tingbao

    2014-06-01

    Paraplegia spasm is a kind of chronic disease which lacks effective treatment; the patients have to endure long-term pain, which is a tough problem for nursing practice. Lots of potential candidate medicines are under investigation, and a new Chinese herb formula is introduced in the current study. In the present study, we chose six different well-known Chinese herbs to form a formula, and boiled them into the water with an optimized ratio to make bath water; 80 paraplegic patients received this medicinal bath, and 80 patients received perfume water bath as placebo group. Compared with placebo control patients, the herb-treated patients have significant reduction in paraplegia spasm, visual analogue scale score, clinician global impression and sleep disorder. This novel six-combined formula traditional medicine could be beneficial for alleviating paraplegia spasm, but the underlying action mechanism deserves further study.

  10. Applicability of various estimation formulas to assess renal function in Chinese children

    Institute of Scientific and Technical Information of China (English)

    Yue Du; Ting-Ting Sun; Ling Hou; Jin-Jie Guo; Xiu-Li Wang; Yu-Bin Wu

    2015-01-01

    Background: This study was to evaluate the relative applicability of the most commonly used estimation formulas for renal glomerular filtration rate (GFR) of Chinese children with chronic kidney disease (CKD). Methods: One hundred CKD patients of less than 17 years old were divided into two groups by sex which was further categorized intofi ve subgroups based on CKD staging according to the "reference" GFR (rGFR) determined by Tc-99m-DTPA renal dynamic imaging. Four GFR markers including serum cystatin C (CysC),β2-microglobulin, creatinine, and blood urea nitrogen were measured. Results: Among all four markers, CysC best refl ected the extent of glomerular damages for CKD stage 1. The value for estimation of GFR (eGFR) was derived from five different formulas either over-estimated or under-estimated GFR as referenced to rGFR, and the extent of deviations was dependent on gender, age and CKD stage. The Counahan-Barratt formula and the Schwartz formula gave the most accurate estimations of GFR for CKD stages 1 and 2-3, respectively regardless of gender and age differences. Receiver operating characteristic analyses indicated that the Counahan-Barratt formula has the highest diagnostic accuracy. Conclusion: The Counahan-Barratt formula provides the best approximation to rGFR, thereby the highest applicability to Chinese children with CKD of different genders, ages and CKD stages.

  11. An improved association-mining research for exploring Chinese herbal property theory: based on data of the Shennong's Classic of Materia Medica.

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    Jin, Rui; Lin, Zhi-jian; Xue, Chun-miao; Zhang, Bing

    2013-09-01

    Knowledge Discovery in Databases is gaining attention and raising new hopes for traditional Chinese medicine (TCM) researchers. It is a useful tool in understanding and deciphering TCM theories. Aiming for a better understanding of Chinese herbal property theory (CHPT), this paper performed an improved association rule learning to analyze semistructured text in the book entitled Shennong's Classic of Materia Medica. The text was firstly annotated and transformed to well-structured multidimensional data. Subsequently, an Apriori algorithm was employed for producing association rules after the sensitivity analysis of parameters. From the confirmed 120 resulting rules that described the intrinsic relationships between herbal property (qi, flavor and their combinations) and herbal efficacy, two novel fundamental principles underlying CHPT were acquired and further elucidated: (1) the many-to-one mapping of herbal efficacy to herbal property; (2) the nonrandom overlap between the related efficacy of qi and flavor. This work provided an innovative knowledge about CHPT, which would be helpful for its modern research.

  12. Chinese Herbal Medicine for Symptom Management in Cancer Palliative Care: Systematic Review And Meta-analysis.

    Science.gov (United States)

    Chung, Vincent C H; Wu, Xinyin; Lu, Ping; Hui, Edwin P; Zhang, Yan; Zhang, Anthony L; Lau, Alexander Y L; Zhao, Junkai; Fan, Min; Ziea, Eric T C; Ng, Bacon F L; Wong, Samuel Y S; Wu, Justin C Y

    2016-02-01

    Use of Chinese herbal medicines (CHM) in symptom management for cancer palliative care is very common in Chinese populations but clinical evidence on their effectiveness is yet to be synthesized. To conduct a systematic review with meta-analysis to summarize results from CHM randomized controlled trials (RCTs) focusing on symptoms that are undertreated in conventional cancer palliative care.Five international and 3 Chinese databases were searched. RCTs evaluating CHM, either in combination with conventional treatments or used alone, in managing cancer-related symptoms were considered eligible. Effectiveness was quantified by using weighted mean difference (WMD) using random effect model meta-analysis. Fourteen RCTs were included. Compared with conventional intervention alone, meta-analysis showed that combined CHM and conventional treatment significantly reduced pain (3 studies, pooled WMD: -0.90, 95% CI: -1.69 to -0.11). Six trials comparing CHM with conventional medications demonstrated similar effect in reducing constipation. One RCT showed significant positive effect of CHM plus chemotherapy for managing fatigue, but not in the remaining 3 RCTs. The additional use of CHM to chemotherapy does not improve anorexia when compared to chemotherapy alone, but the result was concluded from 2 small trials only. Adverse events were infrequent and mild. CHM may be considered as an add-on to conventional care in the management of pain in cancer patients. CHM could also be considered as an alternative to conventional care for reducing constipation. Evidence on the use of CHM for treating anorexia and fatigue in cancer patients is uncertain, warranting further research.

  13. Demographic and Prescribing Patterns of Chinese Herbal Products for Individualized Therapy for Ischemic Heart Disease in Taiwan: Population-Based Study.

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    Yu-Chiang Hung

    Full Text Available Combinations of Chinese herbal products (CHPs are widely used for ischemic heart disease (IHD in Taiwan. We analyzed the usage and frequency of CHPs prescribed for patients with IHD.A nationwide population-based cross-sectional study was conducted, 53531 patients from a random sample of one million in the National Health Insurance Research Database (NHIRD from 2000 to 2010 were enrolled. Descriptive statistics, the multiple logistic regression method and Poisson regression analysis were employed to estimate the adjusted odds ratios (aORs and adjusted risk ratios (aRRs for utilization of CHPs.The mean age of traditional Chinese medicine (TCM nonusers was significantly higher than that of TCM users. Zhi-Gan-Cao-Tang (24.85% was the most commonly prescribed formula CHPs, followed by Xue-Fu-Zhu-Yu-Tang (16.53% and Sheng-Mai-San (16.00%. The most commonly prescribed single CHPs were Dan Shen (29.30%, Yu Jin (7.44%, and Ge Gen (6.03%. After multivariate adjustment, patients with IHD younger than 29 years had 2.62 times higher odds to use TCM than those 60 years or older. Residents living in Central Taiwan, having hyperlipidemia or cardiac dysrhythmias also have higher odds to use TCM. On the contrary, those who were males, who had diabetes mellitus (DM, hypertension, stroke, myocardial infarction (MI were less likely to use TCM.Zhi-Gan-Cao-Tang and Dan Shen are the most commonly prescribed CHPs for IHD in Taiwan. Our results should be taken into account by physicians when devising individualized therapy for IHD. Further large-scale, randomized clinical trials are warranted in order to determine the effectiveness and safety of these herbal medicines.

  14. Immunological regulation of Chinese herbal medicine%中药免疫调节作用的研究进展

    Institute of Scientific and Technical Information of China (English)

    马洪第; 卢芳汀; 陶艳艳; M.Eric Gershwin; 廉哲雄

    2011-01-01

    研究表明中药具有免疫促进和免疫抑制的双向免疫调节作用,本文就中药免疫调节作用的相关研究进行总结,从中药对免疫细胞、细胞因子、免疫器官发育的促进作用及其抗肿瘤的功效,到中药在炎症反应、超敏反应、自身免疫性疾病以及移植排斥反应中所起的免疫抑制作用进行论述,并对中药在免疫调节中的应用前景进行了展望.%Previous studies show that Chinese herbal medicine has dual roles in immunological regulation which include immunological promotion and suppression.This review summarizes both the promotive action of Chinese herbal medicine on immune cells, cytokines,development of immunological organs, and anti-cancer therapy, as well as its suppressive action on inflammation, hypersensitivity,autoimmune diseases, and graft rejection.Lastly, an overview of the future prospects of Chinese herbal medicine in immunological regulation is provided.

  15. Systematic review and meta-analysis of the clinical efficacy and adverse effects of Chinese herbal decoction for the treatment of gout.

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    Liang Zhou

    Full Text Available BACKGROUND: In East Asia, numerous reports describe the utilization of traditional Chinese herbal decoctions to treat gout. However, the reported clinical effects vary. OBJECTIVES: In this study, we reviewed and analyzed a large number of randomized controlled clinical trials to systematically assess the clinical efficacy and adverse reactions of Chinese herbal decoctions for treating gout. METHODS: We performed a comprehensive search of databases, such as PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, Chinese biomedical literature database, et al. In addition, we manually searched the relevant meeting information in the library of the Third Military Medical University. RESULTS: Finally, 17 randomized controlled trials with a sample size of 1,402 cases met the criteria and were included in the study. The results of the meta-analysis showed that when gout had progressed to the stage of acute arthritis, there was no significant difference in clinical efficacy between Chinese herbal decoctions and traditional Western medicine, as indicated based on the following parameters: serum uric acid (standardized mean difference (SMD:0.35, 95% confidence interval (CI: 0.03 to 0.67, C reactive protein (SMD: 0.25, 95% CI: -0.18 to 0.69, erythrocyte sedimentation rate (SMD: 0.21, 95% CI: -0.02 to 0.45 and overall clinical response (relative risk (RR: 1.05, 95% CI: 1.01 to 1.10. However, the Chinese herbal decoction was significantly better than traditional Western medicine in controlling adverse drug reactions (RR: 0.06, 95% CI: 0.03 to 0.13. CONCLUSIONS: Through a systematic review of the clinical efficacy and safety of Chinese herbal decoctions and traditional Western medicine for the treatment of gout, we found that Chinese herbal decoction and traditional Western medicine led to similar clinical efficacy, but the Chinese herbal decoctions were superior to Western medicine in terms of controlling adverse drug reactions.

  16. A review of potential harmful interactions between anticoagulant/antiplatelet agents and Chinese herbal medicines.

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    Hsin-Hui Tsai

    Full Text Available BACKGROUND: The risks attributed to drug-herb interactions, even when known, are often ignored or underestimated, especially for those involving anti-clotting drugs and Chinese medicines. The aim of this study was to structurally search and evaluate the existing evidence-based data associated with potential drug interactions between anticoagulant/antiplatelet drugs and Chinese herbal medicines (CHMs and evaluate the documented mechanisms, consequences, and/or severity of interactions. METHODOLOGY AND FINDINGS: Information related to anticoagulant/antiplatelet drug-CHM interactions was retrieved from eight interaction-based textbooks, four web resources and available primary biomedical literature. The primary literature searches were conducted in English and/or Chinese from January 2000 through December 2011 using the secondary databases (e.g., PubMed, Airiti Library, China Journal full-text database. The search terms included the corresponding medical subject headings and key words. Herbs or natural products not used as a single entity CHM or in Chinese Medicinal Prescriptions were excluded from further review. The corresponding mechanisms and severity ratings of interactions were retrieved using MicroMedex®, Lexicomp® and Natural Medicines Comprehensive Database®. Finally, we found 90 single entity CHMs contributed to 306 documented drug-CHM interactions. A total of 194 (63.4% interactions were verified for its evidence describing possible mechanisms and severity. Of them, 155 interactions (79.9% were attributable to pharmacodynamic interactions, and almost all were rated as moderate to severe interactions. The major consequences of these interactions were increased bleeding risks due to the additive anticoagulant or antiplatelet effects of the CHMs, specifically danshen, dong quai, ginger, ginkgo, licorice, and turmeric. CONCLUSIONS/SIGNIFICANCE: Conventional anticoagulants and antiplatelet drugs were documented to have harmful interactions

  17. Oral Chinese Herbal Medicine for Treatment of Dilated Cardiomyopathy: A Systematic Review and Meta-Analysis

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    Yu-Shuo Zhu

    2016-01-01

    Full Text Available Dilated cardiomyopathy (DCM is one of the main causes of heart failure and could increase death, hospitalization, and rehospitalization rate. The effect of conventional medicine treatment (CMT is limited; meanwhile, the combination of CMT and Oral Chinese Herbal Medicine (OCHM represents exciting adjunctive therapies. In this study, we ascertained the therapeutic effect of OCHM in combination with CMT for dilated cardiomyopathy by using meta-analysis methods for controlled clinical trials. We searched studies from five databases and extracted data from these studies. We also assessed the methodological quality of the included studies. We evaluated the following outcome measures to estimate the prognosis in patients with DCM: left ventricular ejection fraction (LVEF, left ventricular end-diastolic dimension (LVEDD, stroke volume (SV, brain natriuretic peptide (BNP, 6-minute walk test (6MWT, and overall efficacy. The result showed that OCHM combined with CMT for the improvement of therapeutic effect in DCM patients. However, the evidence remains weak due to the small sample size, high clinical heterogeneity, and poor methodological quality of the included trials. Further, large sample size and well-designed trials are needed.

  18. [Application prospect and expectation of fungistatic agents of plants in preservation of Chinese herbal medicines].

    Science.gov (United States)

    Li, Yan-jun; Kong, Wei-jun; Hu, Yi-chen; Zhao, Lian-hua; Yang, Shi-hai; Yang, Mei-hua

    2015-10-01

    During the process of growth, harvesting, transportation, processing and storage, Chinese herbal medicines (CHMs) can be easily contaminated by fungi and their metabolites like mycotoxins, which not only express negative effects on the quality and safety of CHMs and their processed products, but also pose great threats to human health. Now, some chemical synthetic fungicides have been frequently used to control the growth of fungi and accumulation of mycotoxins in the preservation of CHMs. However, the concentration and type of chemical fungicides allowed for postharvest application are restricted due to the disadvantages of their high residual toxicity, long degradation period and pollution to the environment and so on. Therefore, it is critical to research and develop some highly effective, safe and non-toxic, natural, environment-friendly fungistatic agents from plants to prevent CHMs from being contaminated by fungi and mycotoxins. The paper reviews mycotoxins and their harmfulness, the effective compounds of fungistatic plants as well as the antifungal mechanism to provide scientific evidences for developing novel and effective fungistatic agents plants. Then, the application prospect of fungistatic agents from plants in the preservation of CHMs was discussed.

  19. Comprehensive Evaluation of Powdered Chinese Herbal Medicines-An Exemplification of Isatidis Radix

    Institute of Scientific and Technical Information of China (English)

    Xue Han; Ming-quan Wu; Zhi-rui Yang; Ding-kun Zhang; Yi Mao; Jin Han; Yin-qiu Huang; Yong-feng Zhou; Yan-ling Zhao; Jia-bo Wang; Xiao-he Xiao

    2016-01-01

    Objective Currently, powdered Chinese herbal medicines(CHMs) were mainly evaluated through physical property, chemical dissolution, and bioactivity independently. It could not reflect the quality comprehensively. This paper was to explore and establish a comprehensive evaluation method for powdered CHMs. Methods Isatidis Radix was chosen as an exemple. Firstly, powdered Isatidis Radix in different particle size was prepared. Then, their physical properties were characterized. The dissolution of index component epigoitrin was determined, and their antiviral activities were evaluated by neuraminidase-based bioassay. Results As the particle size decreased, powder distribution tended to be uniform, and the dissolution of epigoitrin increased, antiviral activity enhanced. According to cluster analysis of above results, the sequence of evaluation consequence was ultrafine powder S2(D90: 32.80 ± 0.29) > ultrafine powder S1(D90: 52.08 ± 0.53) > fine powder S0(D90: 118.16 ± 0.76)(from the superior to the inferior). Conclusion Overall, the comprehensive evaluation for powdered CHMs based on the physical characterization, chemical dissolution, and bioassay could not only be used to evaluate powdered herbs, but also guide the screening and optimization of the particle size of powder.

  20. Chinese Herbal Medicine Paratherapy for Parkinson's Disease: A Meta-Analysis of 19 Randomized Controlled Trials

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    Yan Wang

    2012-01-01

    Full Text Available Parkinson's disease (PD is a common and debilitating neurodegenerative disorder that needs long-term levodopa administration and can result in progressive deterioration of body functions, daily activities and participation. The objective of this meta-analysis evaluates the clinical efficacy and safety of Chinese herbal medicine (CHM as an adjunct therapy for PD patients. Methodological issues include a systematic literature search between 1950 and April 2011 to identify randomized trials involving CHM adjuvant therapy versus western conventional treatment. The outcome measures assessed were the reduction in scores of Unified Parkinson's Disease Rating Scale (UPDRS and adverse effects. 19 trials involving 1371 participants were included in the meta-analysis. As compared to western conventional treatment, CHM adjuvant therapy resulted in greater improvement in UPDRS I, II, III, IV scores, and UPDRS I–IV total scores (P<0.001. Adverse effects were reported in 9 studies. The side effects in CHM adjuvant therapy group were generally less than or lighter than the conventional treatment group. In conclusion, CHM adjuvant therapy may potentially alleviate symptoms of PD and generally appeared to be safe and well tolerated by PD patients. However, well-designed, randomized, placebo-controlled clinical trials are still needed due to the generally low methodological quality of the included studies.

  1. New Potential Pharmacological Functions of Chinese Herbal Medicines via Regulation of Autophagy

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    Betty Yuen Kwan Law

    2016-03-01

    Full Text Available Autophagy is a universal catabolic cellular process for quality control of cytoplasm and maintenance of cellular homeostasis upon nutrient deprivation and environmental stimulus. It involves the lysosomal degradation of cellular components such as misfolded proteins or damaged organelles. Defects in autophagy are implicated in the pathogenesis of diseases including cancers, myopathy, neurodegenerations, infections and cardiovascular diseases. In the recent decade, traditional drugs with new clinical applications are not only commonly found in Western medicines, but also highlighted in Chinese herbal medicines (CHM. For instance, pharmacological studies have revealed that active components or fractions from Chaihu (Radix bupleuri, Hu Zhang (Rhizoma polygoni cuspidati, Donglingcao (Rabdosia rubesens, Hou po (Cortex magnoliae officinalis and Chuan xiong (Rhizoma chuanxiong modulate cancers, neurodegeneration and cardiovascular disease via autophagy. These findings shed light on the potential new applications and formulation of CHM decoctions via regulation of autophagy. This article reviews the roles of autophagy in the pharmacological actions of CHM and discusses their new potential clinical applications in various human diseases.

  2. Current Evidence of Chinese Herbal Constituents with Effects on NMDA Receptor Blockade

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    David T. Yew

    2013-08-01

    Full Text Available NMDA receptor (NMDA-R is an important molecular entity governing a wide range of functions in the central nervous system. For example, the NMDA-R is involved in memory and cognition, and impairment of both (as in Alzheimer’s Disease is attributed to NMDA-mediated neurotoxicity. With greater understanding of the NMDA-R structure, antagonists with varying degrees of binding-site and subtype selectivity have been developed and put into clinical use. Discovery of target-specific Chinese herbs have also been made in parallel. This article provides an overview of the known active sites on the NMDA-R, followed by a discussion of the relevant herbs and their constituents. Experimental evidence supporting the inhibitory role of the herbal compounds on the NMDA-R is highlighted. For some of the compounds, potential research directions are also proposed to further elucidate the underlying mechanisms of the herbs. It is envisaged that future investigations based on the present data will allow more clinically relevant herbs to be identified.

  3. The Ethics of Traditional Chinese and Western Herbal Medicine Research: Views of Researchers and Human Ethics Committees in Australia

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    Caroline A. Smith

    2011-01-01

    Full Text Available Despite the growth of traditional Chinese medicine (TCM and western herbal medicine (WHM research in Australia, little is known about how ethics committees (HRECs assess the ethics of TCM or WHM research. The objectives of this study were to examine the experiences of TCM and WHM researchers and HRECs with the evaluation of ethics applications. Two cross-sectional surveys were undertaken of HRECs and TCM and WHM researchers in Australia. Anonymous self-completion questionnaires were administered to 224 HRECs and 117 researchers. A response confirming involvement in TCM or WHM research applications was received from 20 HRECs and 42 researchers. The most frequent ethical issues identified by HRECs related to herbal products including information gaps relating to mode of action of herbal medicines and safety when combining herbal ingredients. Researchers concurred that they were frequently requested to provide additional information on multiple aspects including safety relating to the side effects of herbs and herb-drug interactions. Overall adherence with the principles of ethical conduct was high among TCM and WHM researchers although our study did identify the need for additional information regarding assessment of risk and risk management.

  4. Pro-inflammatory effect of a traditional Chinese medicine formula with potent anti-cancer activity in vitro impedes tumor inhibitory potential in vivo

    Science.gov (United States)

    Xia, Lei; Plachynta, Maksym; Liu, Tangjingjun; Xiao, Xiao; Song, Jialei; Li, Xiaogang; Zhang, Mu; Yao, Yao; Luo, Heng; Hao, Xiaojiang; Ben-David, Yaacov

    2016-01-01

    Medicinal formulas are a part of the complex discipline of traditional Chinese medicine that has been used for centuries in China and East Asia. These formulas predominantly consist of the extracts isolated from herbal plants, animal parts and medicinal minerals. The present study aimed to investigate the impact of 150 formulas, used as non-prescription drugs in China, on the treatment of cancer. A formula was identified, C54, commonly used to treat sore throats, which exhibited marked growth inhibition in vitro, associated with cell cycle arrest and apoptosis. Cytotoxicity was, in part, due to the ability of C54 to inhibit the expression and function of the transcription factor, Fli-1, leading to marked inhibition of leukemic cell growth in tissue culture. However, when injected into a model of leukemia initiated by Fli-1 activation, C54 only exhibited a limited tumor inhibition. C54 also did not suppress xenograft growth of the breast cancer cell line, MDA-MB-231, orthopedically transplanted into the mammary fat pad of severe combined immunodeficiency (SCID) mice. Notably, splenomegaly and accumulation of inflammatory CD11b+/Gr1+ monocytes were observed in the tumors and spleens of C54-treated mice. As inflammation is known to accelerate tumor progression, this immune response may counteract the cell-autonomous effect of C54, and account for its limited tumor inhibitory effect in vivo. Combining C54 with an anti-inflammatory drug may improve the potency of C54 for treatment of certain cancers. The present study has highlighted the complexity of Chinese medicinal compounds and the need to thoroughly analyze their systemic effects at high concentrations in vivo.

  5. Circumvention of multi-drug resistance of cancer cells by Chinese herbal medicines

    Directory of Open Access Journals (Sweden)

    Lin Ge

    2010-07-01

    Full Text Available Abstract Multi-drug resistance (MDR of cancer cells severely limits therapeutic outcomes. A proposed mechanism for MDR involves the efflux of anti-cancer drugs from cancer cells, primarily mediated by ATP-binding cassette (ABC membrane transporters including P-glycoprotein. This article reviews the recent progress of using active ingredients, extracts and formulae from Chinese medicine (CM in circumventing ABC transporters-mediated MDR. Among the ABC transporters, Pgp is the most extensively studied for its role in MDR reversal effects. While other MDR reversal mechanisms remain unclear, Pgp inhibition is a criterion for further mechanistic study. More mechanistic studies are needed to fully establish the pharmacological effects of potential MDR reversing agents.

  6. Quality control of Chinese herbal tonic wine by high performance liquid chromatography fingerprint

    NARCIS (Netherlands)

    Wei, X.J.; Zhang, H.; Wang, W.F.; Li, B.; Yang Zhu, Yang

    2007-01-01

    Herbal tonic wines are alcoholic drinks in which medicinal herbs are soaked and extracted. These drinks are considered having various health functions. However, the quality of herbal products is largely influenced by the origin and harvest season of the herbs. Due to its high commercial value, count

  7. The multi-herbal formula Chong-Myung-Tang improves spatial memory and increases cell genesis in the dentate gyrus of aged mice.

    Science.gov (United States)

    Liu, Lei; Zhang, Mingwei; Zhang, Ruifen; Lee, Mira; Wang, Zhen; Hou, Jingang; Sung, Chang-Keun

    2014-01-01

    Chong-Myung-Tang (CMT) is a multi-herbal formula that has been used to improve memory. However, the potential mechanism remains unknown. The present study investigated the effects of CMT (50, 100, and 200 mg/kg) on spatial memory of aged mice. The behavioral training tests indicated that 200 mg/kg CMT treatment can significantly improve spatial memory of aged mice in the Morris water maze. Moreover, cell survival was examined by injecting bromodeoxyuridine (BrdU) on the first three days. The result showed that 200 mg/kg CMT treatment significantly increased cell survival in the dentate gyrus. Cell proliferation was determined by injecting BrdU 2 h before the mice were killed. The result suggested that CMT treatments had no influence on cell proliferation in the dentate gyrus. Thus, an increase in cell survival in the dentate gyrus stimulated by CMT may be involved in the effect of CMT on spatial memory improvement.

  8. Pharmacokinetics of Two Ingredients of the Compound Chinese Herbal Medicine Transdermal Preparation in Cows

    Institute of Scientific and Technical Information of China (English)

    WANG Gui-xia; LI Rui; ZHANG Xiu-ying

    2009-01-01

    The topical administration of the compound Chinese herbal medicine transdermal preparation has been widely used in treating the mastitis of cows.In order to understand the metabolic process,four cows suffering from clinical mastitis were selected for the pharmacokinetie study.The transdermal preparation was applied to the diseased part of breast.Then the plasma and milk samples were collected respectively at 0,0.5,1,2,4,6,8,10,12,24,and 36 h.The concentrations of baicalin and phillyrin in plasma and milk were determined by HPLC and the data of time-concentrations were analyzed by the pharmacokinetic software.The results showed that two ingredients in the plasma were not detectable,but they in the milk had linear relationship with the time.The peak concentration of baicalin [(2.84±0.15) μg mL-1]appeared at (4.93±0.35) h,AUC0-LOQ was(27.32±7.91) mg L-1 h-1,and the mean retention time was (28.31±0.49) h.The peak concentration of phillyrin [(0.49±0.41) μg mL-1]achieved at (3.68 4±3.14) h,AUC0-LOQ was (4.10±0.31) mg L-1 h-1,and the mean retention time was (14.52±0.02) h.These suggested that two ingredients had slow absorbing speed and high absorbing degree.They could not be eliminated in a short time,thus exerted the topical curative effect.

  9. Inhibition effect of Chinese herbal medicine on transcription of hepatitis C virus structural gene in vitro

    Institute of Scientific and Technical Information of China (English)

    Jun Dou; Qian Chen; Jing Wang

    2005-01-01

    AIM: To investigate the inhibitory effect of Chinese herbal medicine on the transcription of hepatitis C virus (HCV) structural gene in Hela D cells.METHODS: Hela cell line was transfected with recombinant pBK-CMV-HCV containing HCV structural gene by Lipofectamine. RT-nested-PCR and Western blot assay were used to testify the HCV gene expression in Hela cells. The Hela cells expressing HCV structural protein were named Hela D cells. Prescriptions of Xiao chaihu Decoction (XCHD),Fufang Huangqi (FFHQ) and Bingganling (BGL) wererespectively added to Hela D cells in various concentrations. Semi-quantitative RT-nested-PCR product analysis was performed according to the fluorescent density between HCV DNA band and GAPDH DNA band in gel electrophoresisafter screened. RESULTS: Recombinant pBK-CMV-HCV could correctly express the HCV structural gene in Hela D cells. After coculture of Hela D cells with three prescriptional different concentrations for 48 h respectively, the transcription of HCVgene decreased with increasing of the concentration of each prescription. The lightness ratio of HCV product bands to GAPDH product bands was 0.24, 0.10 and 0.12 in Hela D cells incubated with 0.1 g/mL of XCHD, FFHQand BGL respectively and the lightness ratio HCV product bands to GAPDH product bands was 0.75, 0.67 and 0.61respectively in the control cells. CONCLUSION: The prescriptions of XCHD, FFHQ and BGL partly inhibit the transcription of HCV structural gene inHela D cells.

  10. [Determination of Total Sulfur Dioxide in Chinese Herbal Medicines via Triple Quadrupole Inductively Coupled Plasma Mass Spectrometry].

    Science.gov (United States)

    Wang, Xiao-wei; Liu, Jing-fu; Guan, Hong; Wang, Xiao-yan; Shag, Bing; Zhang, Jing; Liu, Li-ping; Zhang, Ni-na

    2016-02-01

    As an important treatment method, sulfur fumigation plays an essential role in the production and preservation of traditional Chinese herbal medicines. Although there is strict regulation on the use of sulfur dioxide, the abuse of sulfur dioxide still occurred from time to time. And the public faces a high risk of exposure. Because of the poor precision and tedious preparation procedures of traditional recommended titration, the accurate and convenient determination of sulfur dioxide in Chinese herbal medicines is still a critical analytical task for medicines safety and the public health. In this study, an accurate, high-throughput, and convenient method for the absolute determination of SO₂ in Chinese herbal medicines based on triple quadrupole inductively coupled plasma mass spectrometry (ICP-MS/MS) technique is developed. The study compared the quantitative ability for sulfur when the ICP-MS operated under traditional single quadrupole (QMS) mode and novel triple quadrupole (MS/MS) mode with three Reaction/Collision cell condition (no gas, helium, and oxygen). The result indicated that when the concentration of sulfate ranging from 0.5 to 100 mg · L⁻¹, isotopic ³⁴S can be selected as quantitative ion either the ICP-MS operated under the QMS mode or MS/MS mode. The use of helium in the Reaction/Collision cell decreased the single intensity of background ions. Better than QMS mode, the MS/MS mode can effectively reduced background interference. But there are no significant differences about the linear range and limit of detection. However, when the ICP-MS operated under MS/MS mode and oxygen was used as reaction gas in the Reaction/Collision cell, the ICP-MS/MS provided an interference-free performance, the linear range and limit of detection improved significantly. Either ³²S or ³⁴S exhibits an excellent linearity (r > 0.999) over the concentration range of 0.02-100 mg · L⁻¹, with a limit of detection of 5.48 and 9.76 µg · L⁻¹ for

  11. Twelve Cases of Malignant Hematopathy Treated by Combined Therapy of Hematopoietic Stem Cell Transplantation andChinese Herbal Medicine

    Institute of Scientific and Technical Information of China (English)

    虞荣喜; 周郁鸿; 朱宁希; 沈建平; 胡致平; 罗秀素; 林圣云; 沈一平; 陈均法; 孙洁

    2002-01-01

    Objective:To evaluate the effect of hematopoietic stem cell transplantation combined with Chinese herbal medicine in treating malignant hematopathy.Methods: Allo-bone marrow transplantation (allo-BMT) or allo-peripheral blood stem cell transplantation (allo-PBSCT), with conditioning regimen of 60  Co total body irradiation + Cyclophosphamide (TBI+Cy) or busulfan + cyclophosphamide (Bu+Cy), was used to treat 4 cases of chronic granu locytic leukemia (CGL, 3 of chronic phase and 1 of accelerating phase) and one case of acute non-lymphocytic leukemia (ANLL). And auto-BMT or auto-PBSCT, with conditioning regimen of my leran + cytosino arabinoside +cyclophosphamide (MAC) or MAC+VP16, was used to tr eat 7 cases of hematopathy, including 5 cases of ANLL (3 of CR 1 and 2 of CR 2) and 2 cases of malignant lymphoma (1 of the first occurrence and 1 of relapse). Chinese herbal medicine was given orally to all the 12 patients after transplantation according to TCM Syndrome Differentiation. Results: All patients were successfully engrafted. Within the median follow-up period of 18 (4-70) months, 1 patient (8.3%) died a transplantation-related death, 3 ( 25.0% ) relapsed and 8 (66.7%) survived free of original disease. Conclusion: Auto-BMT or auto-PBSCT in CR 1 stage of acute leukemia could reduce the relapse rate, when there was no matched bone marow donor; allo-BMT or allo-PBSCT in chronic stage could result in long-term disease-free survival of patients; Chinese herbal medicine administration in patients of malignant hematopathy after transplantation might reduce the complications and plays certain rol e in promoting recovery of hematopoietic function.

  12. Research on Chinese Herbal Medicine Fresh-Keeping Paper%中草药保鲜纸的研制

    Institute of Scientific and Technical Information of China (English)

    潘维娜; 施龙; 丁丽; 孔江峰; 沙力争

    2012-01-01

    This paper studied the preparation of flesh-keeping paper by adding cristobalite powder, potassium permanganate (KMnO4) and Chinese herbal medicine into plant fiber, and discussed its fresh-keeping effect on strawberries. Results showed that Chinese herbal medicine fresh-keeping paper can reduce the weight loss rate and cell membrane permeability of strawberries effectively, and improve their sensory effects, The fresh-keeping effect on strawberries is the best when the amount of cristobalite powder, KMnOa and extracts of Chinese herbal medicine are 20%, 3.0% and 75% respectively, and the cell membrane permeability of strawberries is 64.25%.%通过在植物纤维中添加白硅石粉、高锰酸钾和中草药等保鲜剂,制备保鲜纸,以草莓为保鲜对象,研究保鲜纸对其保鲜的效果。结果表明:中草药保鲜纸可有效降低草莓的失重率和细胞膜透性,改善其感观性。保鲜纸中白硅石粉用量为20%、高锰酸钾溶液用量为3.0%、中草药提取液用量为75%时,对草莓的保鲜效果最好,此用量下的草莓细胞膜透性为64.25%。

  13. Effect of Chinese Herbal Fumigation Combined with Tuina on Vertigo and Concentrations of Endothelin and Calcitonin Gene-related Peptide in Patients with Vertebral Artery Cervical Spondylosis

    Institute of Scientific and Technical Information of China (English)

    Zhao Cheng-fei; Liu Xiao-an; Ding Yun

    2014-01-01

    Objective:To observe the effect of Chinese herbal fumigation combined with three-step tuina manipulation on concentration of endothelin (ET) and calcitonin gene-related peptide (CGRP) and vertigo in patients with vertebral artery cervical spondylosis (VACS). Methods:A total of 120 eligible cases were randomly allocated into an observation group and a control group, 60 in each group. Cases in the observation group were treated with Chinese herbal fumigation combined with three-step tuina manipulation, whereas cases in the control group were treated with oral Flunarizine Hydrochloride Capsules. Results: After treatment, vertigo in both groups was alleviated; there were intra-group significant differences in ET decrease and CGRP increase (P Conclusion: Chinese herbal fumigation combined with three-step tuina manipulation can regulate the levels of ET and CGRP and improve vertigo in patients with VACS. Its therapeutic efficacy is superior to oral Flunarizine Hydrochloride Capsules.

  14. Advanced research technology for discovery of new effective compounds from Chinese herbal medicine and their molecular targets.

    Science.gov (United States)

    Wong, Vincent Kam-Wai; Law, Betty Yuen-Kwan; Yao, Xiao-Jun; Chen, Xi; Xu, Su Wei; Liu, Liang; Leung, Elaine Lai-Han

    2016-09-01

    Traditional biotechnology has been utilized by human civilization for long in wide aspects of our daily life, such as wine and vinegar production, which can generate new phytochemicals from natural products using micro-organism. Today, with advanced biotechnology, diverse applications and advantages have been exhibited not only in bringing benefits to increase the diversity and composition of herbal phytochemicals, but also helping to elucidate the treatment mechanism and accelerate new drug discovery from Chinese herbal medicine (CHM). Applications on phytochemical biotechnologies and microbial biotechnologies have been promoted to enhance phytochemical diversity. Cell labeling and imaging technology and -omics technology have been utilized to elucidate CHM treatment mechanism. Application of computational methods, such as chemoinformatics and bioinformatics provide new insights on direct target of CHM. Overall, these technologies provide efficient ways to overcome the bottleneck of CHM, such as helping to increase the phytochemical diversity, match their molecular targets and elucidate the treatment mechanism. Potentially, new oriented herbal phytochemicals and their corresponding drug targets can be identified. In perspective, tighter integration of multi-disciplinary biotechnology and computational technology will be the cornerstone to accelerate new arena formation, advancement and revolution in the fields of CHM and world pharmaceutical industry.

  15. The In Vitro and In Vivo Wound Healing Properties of the Chinese Herbal Medicine “Jinchuang Ointment”

    Directory of Open Access Journals (Sweden)

    Tsung-Jung Ho

    2016-01-01

    Full Text Available “Jinchuang ointment” is a traditional Chinese herbal medicine complex for treatment of incised wounds. For more than ten years, it has been used at China Medical University Hospital (Taichung, Taiwan for the treatment of diabetic foot infections and decubitus ulcers. Three different cases are presented in this study. “Jinchuang” ointment is a mixture of natural product complexes from nine different components, making it difficult to analyze its exact chemical compositions. To further characterize the herbal ingredients used in this study, the contents of reference standards present in a subset of the ointment ingredients (dragon’s blood, catechu, frankincense, and myrrh were determined by HPLC. Two in vitro cell based assay platforms, wound healing and tube formation, were used to examine the biological activity of this medicine. Our results show that this herbal medicine possesses strong activities including stimulation of angiogenesis, cell proliferation, and cell migration, which provide the scientific basis for its clinically observed curative effects on nonhealing diabetic wounds.

  16. Salmonella typhimurium A1-R tumor targeting in immunocompetent mice is enhanced by a traditional Chinese medicine herbal mixture.

    Science.gov (United States)

    Zhang, Yong; Zhang, Nan; Su, Shibing; Hoffman, Robert M; Zhao, Ming

    2013-05-01

    We have developed a bacterial cancer therapy strategy using the genetically-engineered strain Salmonella typhimurium A1-R (A1-R). A1-R is auxotrophic for leu and arg which attenuates bacterial growth in normal tissue but allows high tumor virulence. A1-R is effective against metastatic human and murine cancer cell lines in clinically-relevant nude-mouse models. However, A1-R treatment of tumors in immunocompetent mouse models with high doses is limited by toxicity. The current study evaluated a traditional Chinese medicine (TCM) herbal mixture in combination with A1-R therapy in a syngeneic metastatic immunocompetent mouse model of highly aggressive lung cancer. In a model of Lewis lung carcinoma, the combination of a TCM herbal mixture and S. typhimurium A1-R enabled bacteria to be safely administered at the large dose of 2 × 10(7) colony forming units once a week i.v. with increased treatment efficacy and reduced toxicity compared to monotherapy with A1-R. The herbal mixture prevented body weight loss, spleen weight gain and liver infection by A1-R, as well as hemorrhagic lesions on the skin, liver, and spleen, all observed with A1-R monotherapy. The results of the present study suggest that the combination of A1-R and TCM has important potential for therapy of highly aggressive types of cancer, including those which are resistant to standard therapy.

  17. Effects of three Chinese herbal medicines on plasma and liver lipids in mice fed a high-fat diet.

    Science.gov (United States)

    Nakayama, Tohru; Suzuki, Satoe; Kudo, Hideki; Sassa, Shuji; Nomura, Makoto; Sakamoto, Shinobu

    2007-01-19

    Chinese herbal medicines, Inchinko-to, Bofu-tsusho-san and Dai-saiko-to, containing 3, 18 and 8 components, respectively, have since long been used as an anti-inflammatory, antipyretic, choleretic and diuretic agent for liver disorders and jaundice, as an anti-obesity agent, a hypocholesterolemic agent for liver disorders and a therapeutic and/or preventive agent for cholesterol gallstone disease with hypertriglycerid-emia in China and Japan, respectively. In the present study, we investigated the effects of these three herbal medicines in young male mice fed a high-fat diet. Plasma levels of lipids and the numbers of the fatty droplets in the liver cytoplasm were markedly lowered by the diets supplemented with three herbal medicines. The liver weights and the body growth were reduced by the diet supplemented with Dai-saiko-to, which slightly affected the concentrations of total protein, albumin, creatinine or calcium, and the activity of lactate dehydrogenase. Thus, Dai-saiko-to, besides Bofu-tsusho-san, seems effective in the activities of anti-obesity, anti-hyperlipidemia and anti-hyperlipids in liver cytoplasm, when used carefully.

  18. Involvement of the Cerebral Monoamine Neurotransmitters System in Antidepressant-Like Effects of a Chinese Herbal Decoction, Baihe Dihuang Tang, in Mice Model

    Directory of Open Access Journals (Sweden)

    Meng-Li Chen

    2012-01-01

    Full Text Available Baihe Dihuang Tang (BDT is a renowned Chinese herbal formula which is commonly used for treating patients with mental instability, absentmindedness, insomnia, deficient dysphoria, and other psychological diseases. These major symptoms closely associated with the depressive disorders. BDT was widely popular use for treating emotion-thought disorders for many years in China. In the present study, the antidepressant-like effect of BDT in mice was investigated by using the forced swim test (FST and the tail suspension test (TST. The underlying mechanism was explored by determining the effect of BDT on the level of cerebral monoamine neurotransmitters. BDT (9 and 18 g/kg, p.o. for 14 days administration significantly reduced the immobility time in both the FST and the TST without changing locomotion in the open field-test (OFT. Moreover, BDT treatment at the dose of 18 g/kg inhibited reserpine-induced ptosis. Meanwhile, BDT enhanced 5-HT and NA levels in mouse cerebrum as well as decreased the ratio of 5-HT compared to its metabolite, 5-HIAA, (turnover, 5-HIAA/5-HT after TST. The results demonstrated that the antidepressant-like effect of BDT is mediated, at least partially, via the central monoaminergic neurotransmitter system.

  19. 中草药抗白念珠菌作用研究进展%Research progress of Chinese herbal medicine against Candida albicans

    Institute of Scientific and Technical Information of China (English)

    李姝毅; 夏志宽; 杨蓉娅

    2013-01-01

    Candida albicans is one of the most common human fungal pathogen,which can cause a variety of superficial and deep mycoses,and often become resistant to commonly used antifungal agents.So looking for broad-spectrum,high efficiency,low toxicity anti-Candida drugs has became a hot research.Extremely rich resources of Chinese herbal medicine have certain advantages of the prevention and treatment of Candida infections.To study the role of Chinese herbal medicine against Candida albicans,articles summarize the three aspects:herbal mechanism of action against Candida albicans and its active ingredient,single herb and compound herbal preparations against Candida albicans,synergistic effect of compound traditional Chinese medicine and western medicine against Candida albicans.The Chinese herbal medicine against Candida albicans clinical and experimental studies in recent years were reviewed.The article further confirmed the role of herbal anti-Candida albicans and showed the broad application prospects of herbal antifungal aspects.%白念珠菌,是人类最常见的真菌病原体,可引起各种浅表及深部真菌病,对常用抗真菌药物易产生耐药.文章就近年来有关中草药抗白念珠菌的相关临床及实验研究进行综述,主要从中草药抗白念珠菌的作用机制及其活性成分、单味及复方中草药制剂抗白念珠菌作用、中西药协同抗白念珠菌作用几个方面进行阐述.

  20. Study on Incompatibility of Traditional Chinese Medicine: Evidence from Formula Network, Chemical Space, and Metabolism Room

    Directory of Open Access Journals (Sweden)

    Wei Long

    2013-01-01

    Full Text Available A traditional Chinese medicine (TCM formula network including 362 TCM formulas was built by using complex network methodologies. The properties of this network were analyzed including network diameter, average distance, clustering coefficient, and average degree. Meanwhile, we built a TCM chemical space and a TCM metabolism room under the theory of chemical space. The properties of chemical space and metabolism room were calculated and analyzed. The properties of the medicine pairs in “eighteen antagonisms and nineteen mutual inhibitors,” an ancient rule for TCM incompatibility, were studied based on the TCM formula network, chemical space, and metabolism room. The results showed that the properties of these incompatible medicine pairs are different from those of the other TCM based on the analysis of the TCM formula network, chemical space, and metabolism room. The lines of evidence derived from our work demonstrated that the ancient rule of TCM incompatibility, “eighteen antagonisms and nineteen mutual inhibitors,” is probably scientifically based.

  1. 对目前中药材价格上涨因素的一些分析%The analysis of the current Chinese herbal medicines prices factors

    Institute of Scientific and Technical Information of China (English)

    印敏

    2013-01-01

    Objective To use to predict the moving average method, in order to understand the Chinese herbal medicine prices trend, analysis of Chinese herbal medicines prices faced by various factors. Methods Moving average method to forecast the years can reflect the balance of supply and demand in the market, and consumer accumulation relationship of Chinese herbal medicines and proprietary Chinese medicine retail price index uses. Results The Chinese herbal medicines prices trend existed for a long time. Conclusion Chinese herbal medicine prices face Various factors and rising pressure. And through the analysis of these factors, promote the perfection of regulating supervision mechanism of the traditional Chinese medicine production and prices.%目的:运用移动平均法进行预测,以了解中药材价格的趋势,分析中药材价格上涨面临的各种因素。方法对这几年能反映市场供需的平衡、消费与积累关系的中药材及中成药零售价格指数部分运用移动平均法预测。结果中药材价格上涨趋势存在。结论中药材价格面临各种因素,上涨压力明显。并通过对这些因素的分析,促进完善中药生产和价格调节监督机制。

  2. Evaluating the Bone Tissue Regeneration Capability of the Chinese Herbal Decoction Danggui Buxue Tang from a Molecular Biology Perspective

    Directory of Open Access Journals (Sweden)

    Wen-Ling Wang

    2014-01-01

    Full Text Available Large bone defects are a considerable challenge to reconstructive surgeons. Numerous traditional Chinese herbal medicines have been used to repair and regenerate bone tissue. This study investigated the bone regeneration potential of Danggui Buxue Tang (DBT, a Chinese herbal decoction prepared from Radix Astragali (RA and Radix Angelicae Sinensis (RAS, from a molecular biology perspective. The optimal ratio of RA and RAS used in DBT for osteoblast culture was obtained by colorimetric and alkaline phosphatase (ALP activity assays. Moreover, the optimal concentration of DBT for bone cell culture was also determined by colorimetric, ALP activity, nodule formation, Western blotting, wound-healing, and tartrate-resistant acid phosphatase activity assays. Consequently, the most appropriate weight ratio of RA to RAS for the proliferation and differentiation of osteoblasts was 5 : 1. Moreover, the most effective concentration of DBT was 1,000 μg/mL, which significantly increased the number of osteoblasts, intracellular ALP levels, and nodule numbers, while inhibiting osteoclast activity. Additionally, 1,000 μg/mL of DBT was able to stimulate p-ERK and p-JNK signal pathway. Therefore, DBT is highly promising for use in accelerating fracture healing in the middle or late healing periods.

  3. Enhancement of the Immune Response to Rabbit Hemorrhagic Disease Vaccine in Young Rabbits by Advanced Vaccination and Chinese Herbal Adjuvants

    Institute of Scientific and Technical Information of China (English)

    YANG Long-sheng; XUE Jia-bin; HU Yuan-liang; WANG Fang; WANG De-yun; XU Wei-zhong

    2008-01-01

    Experiments were conducted to determine the effects of advanced vaccination and Chinese herbal adjuvants (CHA), containing astragalus polysaccharides (APS) and ginsenosides (GS) on the immune response to rabbit hemorrhagic disease (RHD) vaccine in young rabbits. In experiment 1, 5 New Zealand rabbits of each group at 30, 35, 40, or 45 days of age were injected with 2 mL of inactivated RHD vaccine, respectively. The dynamic changes of antibody liters were tested by the hemagglutination inhibition (HI) method. In experiment 2, 30 New Zealand rabbits at 35 days of age were randomly assigned to 5 treatment groups, representing inoculation with 3 mL of non-adjuvant RHD vaccine, CHA-RHD vaccine, CHA-HA vaccine (half dose antigen), aluminium adjuvant-RHD vaccine, and PBS, respectively. The dynamic changes of peripheral lymphocyte proliferation and serum antibody liters were tested by the MTT method and the HI method. The results showed that the titer of maternal HI antibody in the 35-day-old rabbits was lower than the protective level of 3 log2, while on days 7 to 49 after the vaccination, the antibody tilers were higher than 3 log2. The CHA promoted me lymphocyte proliferation and enhanced the serum antibody liter (P<0.05). These findings from the two experiments suggested that advanced vaccination and Chinese herbal adjuvants significantly enhanced the immune response lo vaccine againsl RHD, and effectively protected the young rabbils againsl RHD challenge.

  4. Heavy metal and pesticide content in commonly prescribed individual raw Chinese Herbal Medicines

    Energy Technology Data Exchange (ETDEWEB)

    Harris, Eric S.J., E-mail: eric.sj.harris@gmail.com [Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115 (United States); Osher Research Center, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115 (United States); Cao, Shugeng [Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115 (United States); Littlefield, Bruce A. [Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115 (United States); Osher Research Center, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115 (United States); Craycroft, Jane A.; Scholten, Robert [Osher Research Center, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115 (United States); Kaptchuk, Ted [Osher Research Center, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115 (United States); Department of Medicine, Division of General Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215 (United States); Fu, Yanling [International Cooperation Center, Beijing University of Chinese Medicine, 11 Bai San Huan Dong Lu, Chao Yang District, Beijing 100029 (China); Wang, Wenquan; Liu, Yong [School of Chinese Pharmacy, Beijing University of Chinese Medicine, No. 6 Wangjing Zhong Huan Nan Lu, Chaoyang District, Beijing 100102 (China); Chen, Hubiao; Zhao, Zhongzhen [School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Hong Kong Special Administrative Region (China); Clardy, Jon [Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115 (United States); Woolf, Alan D. [Children' s Hospital Boston, 300 Longwood Avenue and Department of Pediatrics, Harvard Medical School, Boston, MA 02118 (United States); and others

    2011-09-15

    Heavy metal and pesticide contamination has previously been reported in Chinese Herbal Medicines (CHMs), in some cases at potentially toxic levels. This study was conducted to determine general patterns and toxicological significance of heavy metal and pesticide contamination in a broad sample of raw CHMs. Three-hundred-thirty-four samples representing 126 species of CHMs were collected throughout China and examined for arsenic, cadmium, chromium, lead, and mercury. Of the total, 294 samples representing 112 species were also tested for 162 pesticides. At least 1 metal was detected in all 334 samples (100%) and 115 samples (34%) had detectable levels of all metals. Forty-two different pesticides were detected in 108 samples (36.7%), with 1 to 9 pesticides per sample. Contaminant levels were compared to toxicological reference values in the context of different exposure scenarios. According to a likely scenario of CHM consumption, only 3 samples (1%) with heavy metals and 14 samples (5%) with pesticides were found with concentrations that could contribute to elevated background levels of contaminant exposure. According to the most conservative scenario of CHM consumption, 231 samples (69%) with heavy metals and 81 samples (28%) with pesticides had contaminants that could contribute to elevated levels of exposure. Wild collected plants had higher contaminant levels than cultivated samples. Cadmium, chromium, lead, and chlorpyrifos contamination showed weak correlations with geographic location. Based on our assumptions of the likely mode of consumption of raw CHMs, the vast majority (95%) of the 334 samples in this study contained levels of heavy metals or pesticides that would be of negligible concern. However, given the number of samples with detectable contaminants and the range between the more likely and more conservative scenarios of contaminant exposure, more research and monitoring of heavy metals (especially cadmium and chromium) and pesticide residues

  5. Oral Chinese herbal medicine combined with pharmacotherapy for stable COPD: a systematic review of effect on BODE index and six minute walk test.

    Directory of Open Access Journals (Sweden)

    Xiankun Chen

    Full Text Available This systematic review evaluated the effects of Chinese herbal medicine (CHM plus routine pharmacotherapy (RP on the objective outcome measures BODE index, 6-minute walk test (6MWT, and 6-minute walk distance (6MWD in individuals with stable chronic obstructive pulmonary disease (COPD. Searches were conducted of six English and Chinese databases (PubMed, EMBASE, CENTRAL, CINAHL, CNKI and CQVIP from their inceptions until 18th November 2013 for randomized controlled trials involving oral administration of CHM plus RP compared to the same RP, with BODE Index and/or 6MWT/D as outcomes. Twenty-five studies were identified. BODE Index was used in nine studies and 6MWT/D was used in 22 studies. Methodological quality was assessed using the Cochrane Risk of Bias tool. Weaknesses were identified in most studies. Six studies were judged as 'low' risk of bias for randomisation sequence generation. Twenty-two studies involving 1,834 participants were included in the meta-analyses. The main meta-analysis results showed relative benefits for BODE Index in nine studies (mean difference [MD] -0.71, 95% confidence interval [CI] -0.94, -0.47 and 6MWT/D in 17 studies (MD 54.61 meters, 95%CI 33.30, 75.92 in favour of the CHM plus RP groups. The principal plants used were Astragalus membranaceus, Panax ginseng and Cordyceps sinensis. A. membranaceus was used in combination with other herbs in 18 formulae in 16 studies. Detailed sub-group and sensitivity analyses were conducted. Clinically meaningful benefits for BODE Index and 6MWT were found in multiple studies. These therapeutic effects were promising but need to be interpreted with caution due to variations in the CHMs and RPs used and methodological weakness in the studies. These issues should be addressed in future trials.

  6. CLINICAL ANALYSIS ON THE TREATMENT OF FACIAL PARALYSIS BY ACUPUNCTURE, MOXIBUSTION PLUS CHINESE HERBAL MEDICINES

    Institute of Scientific and Technical Information of China (English)

    ZHANG Li-sha; SHEN Wei-hong

    2005-01-01

    Objective:To observe the therapeutic effect of the integrated acupuncture-moxibustion and herbal therapies for facial paralysis. Methods: A total of 68 cases of facial paralysis were treated by integration of acupuncture-moxibustion and herbal therapies. For facial palsy patients with wind-phlegm blocking meridian-collaterals and wind-stirring due to yin deficiency types in the acute stage, Modified respectively; and for those in convalescent stage and sequela stage, Replenishing Blood) + Qian Zheng San (Powder for Treating Wry-mouth) and Recuperation) were employed. Results: After the treatment, the curative rate of the 68 cases accounted for 90% of the total cases, the remarkably effective 6%, the improved 3% and the poor 1% respectively. Conclusion: The therapeutic effectiveness of the integrated treatment of acupuncture-moxibustion and herbal therapies for facial paralysis is certain.

  7. A Review on the Traditional Chinese Medicinal Herbs and Formulae with Hypolipidemic Effect

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    Tung-Ting Sham

    2014-01-01

    Full Text Available Hyperlipidemia, characterized by the abnormal blood lipid profiles, is one of the dominant factors of many chronic diseases such as diabetes, obesity, and cardiovascular diseases (CVD. For the low cost, effectiveness, and fewer side effects, the popularity of using traditional Chinese medicine (TCM to handle hyperlipidemia is increasing and its role in health care has been recognized by the public at large. Despite the importance of TCM herbs and formulations, there is no comprehensive review summarizing their scientific findings on handling hyperlipidemia. This review summarizes the recent experimental and clinical results of nine representative single Chinese herbs and seven classic TCM formulae that could improve lipid profiles so as to help understand and compare their underlying mechanisms. Most of single herbs and formulae demonstrated the improvement of hyperlipidemic conditions with multiple and diverse mechanisms of actions similar to conventional Western drugs in spite of their mild side effects. Due to increasing popularity of TCM, more extensive, well-designed preclinical and clinical trials on the potential synergistic and adverse side effects of herb-drug interactions as well as their mechanisms are warranted. Hyperlipidemic patients should be warned about the potential risks of herb-drug interactions, particularly those taking anticoagulants and antiplatelet drugs.

  8. Concurrent Use of Hypnotic Drugs and Chinese Herbal Medicine Therapies among Taiwanese Adults with Insomnia Symptoms: A Population-Based Study

    OpenAIRE

    Kuei-Hua Lee; Yueh-Ting Tsai; Jung-Nien Lai; Shun-Ku Lin

    2013-01-01

    Background. The increased practice of traditional Chinese medicine (TCM) worldwide has raised concerns regarding herb-drug interactions. The purpose of our study is to analyze the concurrent use of Chinese herbal products (CHPs) among Taiwanese insomnia patients taking hypnotic drugs. Methods. The usage, frequency of services, and CHP prescribed among 53,949 insomnia sufferers were evaluated from a random sample of 1 million beneficiaries in the National Health Insurance Research Database. A...

  9. Chinese herbal medicines for the treatment of type A H1N1 influenza: a systematic review of randomized controlled trials.

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    Wei Chen

    Full Text Available BACKGROUND: Chinese herbs are thought to be effective for type A H1N1 influenza. Series of Chinese herbs have been authorized recommended by the Chinese government, and until now a number of clinical trials of Chinese herbs for H1N1 influenza have been conducted. However, there is no critically appraised evidence such as systematic reviews or meta-analyses on potential benefits and harms of medicinal herbs for H1N1 influenza to justify their clinical use and their recommendation. METHODS AND FINDINGS: CENTRAL, MEDLINE, EMBASE, CBM, CNKI, VIP, China Important Conference Papers Database, China Dissertation Database, and online clinical trial registry websites were searched for published and unpublished randomized controlled trials (RCTs of Chinese herbs for H1N1 influenza till 31 August, 2011. A total of 26 RCTs were identified and reviewed. Most of the RCTs were of high risk of bias with flawed study design and poor methodological quality. The combination of several Chinese herbal medicines with or without oseltamivir demonstrated positive effect on fever resolution, relief of symptoms, and global effectiveness rate compared to oseltamivir alone. However, only one herbal medicine showed positive effect on viral shedding. Most of the trials did not report adverse events, and the safety of herbal medicines is still uncertain. CONCLUSIONS: Some Chinese herbal medicines demonstrated potential positive effect for 2009 type A H1N1 influenza; however, due to the lack of placebo controlled trial and lack of repeated test of the intervention, we could not draw confirmative conclusions on the beneficial effect of Chinese herbs for H1N1 influenza. More rigorous trials are warranted to support their clinical use.

  10. Clinical Study on Chinese Herbal Enema in Adjuvant Treatment of Uremia%中药灌肠辅助治疗尿毒症的临床研究

    Institute of Scientific and Technical Information of China (English)

    吕丽萍

    2015-01-01

    Objective: To investigate effect of Chinese herbal enema with hemodialysis in adjuvant treatment of uremia.Method: Patients (76 cases) with uraemia in telophase were randomly divided into two groups: Chinese herbal enema with hemodialysis group (n=38), and conventional hemodialysis group (n=38). Chinese herbal enema with hemodialysis group reduced hemodialysis times and prolonged hemodialysis interval for 4 weeks to observe the changes of every clinical parameters.Result: There was no significant difference between the two groups (P>0.05). Chinese herbal enema with hemodialysis group was better than conventional hemodialysis group in protecting residual renal function (P0.05);辅助治疗组较透析对照组透析时间间隔明显延长,治疗后对残余肾功能保护作用明显优于对照组,比较差异有统计学意义(P<0.05)。结论:中药灌肠辅助治疗配合血液透析在不影响透析效果的前提下,较单纯的血液透析明显改善了患者生活质量,显著延长透析时间间隔,并可以适度延缓残余肾功能恶化的进展。

  11. Alkaloid profiling of the Chinese herbal medicine Fuzi by combination of matrix-assisted laser desorption ionization mass spectrometry with liquid chromatography-mass spectrometry

    NARCIS (Netherlands)

    Wang, J.; Heijden, R. van der; Spijksma, G.; Reijmers, T.; Wang, M.; Xu, G.; Hankemeier, T.; Greef, J. van der

    2009-01-01

    A matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS) method was developed for the high throughput and robust qualitative profiling of alkaloids in Fuzi-the processed lateral roots of the Chinese herbal medicine Aconitum carmichaeli Debx (A. carmichaeli). After optimization, pow

  12. Twenty-eight Cases of Diabetic Foot Ulcer and Gangrene Treated with the Chinese Herbal Medicine Combined with Injection of Ahylsantinfarctase

    Institute of Scientific and Technical Information of China (English)

    王凡

    2002-01-01

    @@ Since 1995, the Chinese herbal medicine for supplementing qi and activating blood circulation combined with injection of ahylsantinfarctase into the femoral artery has been used in 28 cases of diabetes complicated with gangrene and ulcer of the foot, with quite good therapeutic effects as reported in the following.

  13. Effects of Chinese herbal monomers on oxidative phosphorylation and membrane potential in cerebral mitochondria isolated from hypoxia-exposed rats in vitro

    Institute of Scientific and Technical Information of China (English)

    Weihua Yan; Junze Liu

    2012-01-01

    Mitochondrial dysfunction is the key pathogenic mechanism of cerebral injury induced by high-altitude hypoxia. Some Chinese herbal monomers may exert anti-hypoxic effects through enhancing the efficiency of oxidative phosphorylation. In this study, effects of 10 kinds of Chinese herbal monomers on mitochondrial respiration and membrane potential of cerebral mitochondria isolated from hypoxia-exposed rats in vitro were investigated to screen anti-hypoxic drugs. Rats were exposed to a low-pressure environment of 405.35 mm Hg (54.04 kPa) for 3 days to establish high-altitude hypoxic models. Cerebral mitochondria were isolated and treated with different concentrations of Chinese herbal monomers (sinomenine, silymarin, glycyrrhizic acid, baicalin, quercetin, ginkgolide B, saffron, piperine, ginsenoside Rg1 and oxymatrine) for 5 minutes in vitro. Mitochondrial oxygen consumption and membrane potential were measured using a Clark oxygen electrode and the rhodamine 123 fluorescence analysis method, respectively. Hypoxic exposure significantly decreased the state 3 respiratory rate, respiratory control rate and mitochondrial membrane potential, and significantly increased the state 4 respiratory rate. Treatment with saffron, ginsenoside Rg1 and oxymatrine increased the respiratory control rate in cerebral mitochondria isolated from hypoxia-exposed rats in dose-dependent manners in vitro, while ginsenoside Rg1, piperine and oxymatrine significantly increased the mitochondrial membrane potential in cerebral mitochondria from hypoxia-exposed rats. The Chinese herbal monomers saffron, ginsenoside Rg1, piperine and oxymatrine could thus improve cerebral mitochondrial disorders in oxidative phosphorylation induced by hypobaric hypoxia exposure in vitro.

  14. Application of the HACCP system in the Chinese herbal health tonic industry%HACCP在中草药保健口服液中的应用

    Institute of Scientific and Technical Information of China (English)

    王涛; 陆智; 李德灵

    2012-01-01

    The application of the hazard analysis and critical control point system(HACCP) in the Chinese herbal health tonic industry were described in detail in this paper,taking the Infinitus Health Tonic as example,in order to promote the application of HACCP system in the Chinese herbal health tonic industry and improve the normalization and the standardization of the Chinese herbal health tonic products as well as the management level of the Chinese herbal health tonic industry.%本文以无限极增健口服液为例,详细地介绍了HACCP体系在中草药保健口服液行业的应用,旨在促进HACCP体系在中草药保健口服液中的进一步推广,从而提高中草药保健口服液的规范化、标准化生产经营水平。

  15. Herbal Formula HT048 Attenuates Diet-Induced Obesity by Improving Hepatic Lipid Metabolism and Insulin Resistance in Obese Rats

    Directory of Open Access Journals (Sweden)

    Yoon Hee Lee

    2016-10-01

    Full Text Available It is well established that obesity causes a variety of chronic diseases such as cardiovascular diseases and diabetes. Despite the diligent scientific efforts to find effective ways to lower the level of obesity, the size of obese population grows continuously around the world. Here we present the results that show feeding diet containing HT048, a mixture of the extracts of Crataegus pinnatifida leaves and Citrus unshiu peel, two of the well-known traditional herbal medicines in Eastern Asia, decreases obesity in rats. We fed rats with five different diets for 10 weeks: chow diet (STD, high-fat diet (HFD, high-fat diet with 0.04% orlistat, a drug to treat obesity (HFD + Orlistat, high-fat diet with 0.2% HT048 (w/w; HFD + 0.2% HT048, and high-fat diet with 0.6% HT048 (w/w; HFD + 0.6% HT048. It was found that both body and total white adipose tissue weight of HT048 groups significantly decreased compared to those of the HFD group. Moreover, HT048 decreased serum insulin levels in HFD-fed obese rats. At the molecular level, HT048 supplementation downregulated genes involved in lipogenesis, gluconeogenesis, and adipogenesis, while the expression level of β-oxidation genes was increased. Supplementation-drug interactions are not likely as HFD and HT048-containing diet did not significantly induce genes encoding CYPs. Collectively, this study suggests that HT048 taken as dietary supplement helps to decrease obesity and insulin resistance in HFD-fed obese rats.

  16. 定量小包装中药饮片使用体会%Application Experience of Chinese Herbal Pieces in Quantitative and Small Package

    Institute of Scientific and Technical Information of China (English)

    王卡珂

    2015-01-01

    Chinese herbal pieces in quantitative and small package were qualifiedly processed Chinese herbal pieces distributed into small package of different specifications according to the clinical commonly used dose. Chinese herbal pieces in quantitative and small package is a kind of new deployment model of Chinese herbal pieces. It has the advantage of no need to weigh, high speed of ,regulation and distribution, saving resources, improving the degree of sanitary, directly regulation and distribution by the pharmacist, accurate dose and formulation of high efficiency, etc. Based on the above advantages, this paper mainly summarized the experience of the application of Chinese herbal pieces in quantitative and small package.%定量小包装的中药饮片指的是加工合格后的中药饮片,并按照临床上的常用剂量通过一定的包装分成不同规格的小包装的药剂。中药饮片定量小包装是当前一种新型中药饮片的调配模式,其不需要称量、调配速度快、节约资源、提高卫生度并且直接由药剂师进行调配,并有着剂量准确与配方的效率高等优点。基于此,本文主要对使用定量小包装的中药饮片体会进行分析。

  17. Optimization of the extraction process for the seven bioactive compounds in Yukmijihwang-tang, an herbal formula, using response surface methodology

    Science.gov (United States)

    Kim, Jung-Hoon; Shin, Hyeun-Kyoo; Seo, Chang-Seob

    2014-01-01

    Background: Yukmijihwang-tang (YJT) contains multiple bioactive compounds. Heat-reflux extraction was employed and optimized for the extraction of the bioactive compounds in YJT. Objective: The determination of optimal conditions with maximum yields of bioactive compounds, gallic acid, 5-hydroxymethylfurfural, morroniside, loganin, paeoniflorin, benzoic acid and paeonol, in YJT. Materials and Methods: The extraction ratio (ratio of water to herbal formula), extraction time and extraction number were set as individual values and the yields of the seven compounds were the response values that were optimized with a Box–Behnken design. Results: The optimal conditions obtained from response surface methodology (RSM) were 1:11.99 for the extraction ratio, 94.53 min for the extraction time and 2.21 for the extraction number. Under the optimal conditions, the response value of the experiment closely agreed with the predicted response value. Conclusions: The result suggests that RSM is successfully applied for optimizing the extraction of the marker compounds in YJT. PMID:25298681

  18. Traditional Herbal Formula Banhasasim-tang Exerts Anti-Inflammatory Effects in RAW 264.7 Macrophages and HaCaT Keratinocytes

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    Seong Eun Jin

    2015-01-01

    Full Text Available Banhasasim-tang (BHSST is a Korean traditional herbal formula comprising eight medicinal herbs. The aim of the present study was to investigate the anti-inflammatory effect of BHSST using macrophage and keratinocyte cell lines. First, we evaluated the effects of BHSST on inflammatory mediator and cytokine production in lipopolysaccharide- (LPS- stimulated RAW 264.7 macrophages. BHSST markedly inhibited the production of nitric oxide (NO, prostaglandin E2 (PGE2, and interleukin- (IL- 6. BHSST significantly suppressed the protein expression of toll-like receptor 4 (TLR4 and phosphorylated nuclear factor-kappa B (NF-κB p65 in RAW 264.7 cells. Second, we examined whether BHSST influences the production of chemokines and STAT1 phosphorylation in tumor necrosis factor-α/interferon-γ TI-stimulated HaCaT keratinocytes. BHSST significantly suppressed the production of RANTES/CCL5, TARC/CCL17, MDC/CCL22, and IL-8 in TI-stimulated HaCaT cells. BHSST also suppressed TI-induced phosphorylation of STAT1 in HaCaT cells. These results suggest that BHSST may be useful as an anti-inflammatory agent, especially for inflammatory skin diseases.

  19. Investigation of targeted pyrrolizidine alkaloids in traditional Chinese medicines and selected herbal teas sourced in Ireland using LC-ESI-MS/MS.

    Science.gov (United States)

    Griffin, Caroline T; Gosetto, Francesca; Danaher, Martin; Sabatini, Stefano; Furey, Ambrose

    2014-01-01

    Publications linking hepatotoxicity to the use of herbal preparations are escalating. Herbal teas, traditional Chinese medicines (TCMs) and dietary supplements have been shown to contain pyrrolizidine alkaloids (PAs). Acute PA toxicosis of the liver can result in sinusoidal-obstruction syndrome, also known as veno-occlusive disease (VOD). This paper describes a sensitive and robust method for the detection of targeted PAs and their N-oxides (PANOs) in herbal products (selected herbal teas and TCMs) sourced within Ireland. The sample preparation includes a simple acidic extraction with clean-up via solid-phase extraction (SPE). Sample extracts were accurately analysed by using LC-ESI-MS/MS applying for the first time a pentafluorophenyl (PFP) core-shell column to the chromatographic separation of PAs and PANOs. The method was validated for selectivity, taking into consideration matrix effects, specificity, linearity, precision and trueness. Limits of detection (LOD) and limits of quantitation (LOQ) were quantified for all PAs and PANOs ranging from 0.4 to 1.9 µg kg⁻¹ and from 1.3 to 6.3 µg kg⁻¹, respectively. In this study 10 PAs and four PANOs were targeted because they are commercially available as reference standards. Therefore, this study can only report the levels of these PAs and PANOs analysed in the herbal teas and TCMs. The results reported represent the minimum levels of PAs and PANOs present in the samples analysed; commercially available herbal teas (n = 18) and TCMs (n = 54). A total of 50% herbal teas and 78% Chinese medicines tested positive for one or more PAs and/or PANOs included within this study, ranging from 10 to 1733 and from 13 to 3668 µg kg⁻¹, respectively.

  20. Chinese herbal extracts of Rubia cordifolia and Dianthus superbus suppress IgE production and prevent peanut-induced anaphylaxis

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    Yang Nan

    2011-09-01

    Full Text Available Abstract Background Peanut allergy is characterized by increased levels of peanut-specific IgE in the serum of most patients. Thus, the most logical therapy would be to inhibit the IgE production by committed B-cells. This study aims to investigate the unreported anti-IgE effects of Chinese herbal extracts of Rubia cordifolia (Qiancao and Dianthus superbus (Qumai. Methods Seventy herbal extracts were tested for their ability to reduce IgE secretion by a human B-cell line. Those with the lowest inhibitory concentration 50 (IC50 values were tested in a mouse model of peanut-anaphylaxis. Anaphylactic scores, body temperature, plasma histamine and peanut-specific-immunoglobulins were determined. Results Rubia cordifolia and Dianthus superbus inhibited the in vitro IgE production by a human B-cell line in a dose-dependent manner and the in vivo IgE production in a murine model of peanut allergy without affecting peanut-specific-IgG1 levels. After challenge, all mice in the sham groups developed anaphylactic reactions and increased plasma histamine levels. The extract-treated mice demonstrated significantly reduced peanut-triggered anaphylactic reactions and plasma histamine levels. Conclusion The extracts of Rubia cordifolia and Dianthus superbus inhibited the IgE production in vivo and in vitro as well as reduced anaphylactic reactions in peanut-allergic mice, suggesting potentials for allergy treatments.

  1. Statistical modeling methods to analyze the impacts of multiunit process variability on critical quality attributes of Chinese herbal medicine tablets

    Directory of Open Access Journals (Sweden)

    Sun F

    2016-11-01

    Full Text Available Fei Sun,1 Bing Xu,1,2 Yi Zhang,1 Shengyun Dai,1 Chan Yang,1 Xianglong Cui,1 Xinyuan Shi,1,2 Yanjiang Qiao1,2 1Research Center of Traditional Chinese Medicine Information Engineering, School of Chinese Materia Medica, Beijing University of Chinese Medicine, 2Key Laboratory of Manufacture Process Control and Quality Evaluation of Chinese Medicine, Beijing, People’s Republic of China Abstract: The quality of Chinese herbal medicine tablets suffers from batch-to-batch variability due to a lack of manufacturing process understanding. In this paper, the Panax notoginseng saponins (PNS immediate release tablet was taken as the research subject. By defining the dissolution of five active pharmaceutical ingredients and the tablet tensile strength as critical quality attributes (CQAs, influences of both the manipulated process parameters introduced by an orthogonal experiment design and the intermediate granules’ properties on the CQAs were fully investigated by different chemometric methods, such as the partial least squares, the orthogonal projection to latent structures, and the multiblock partial least squares (MBPLS. By analyzing the loadings plots and variable importance in the projection indexes, the granule particle sizes and the minimal punch tip separation distance in tableting were identified as critical process parameters. Additionally, the MBPLS model suggested that the lubrication time in the final blending was also important in predicting tablet quality attributes. From the calculated block importance in the projection indexes, the tableting unit was confirmed to be the critical process unit of the manufacturing line. The results demonstrated that the combinatorial use of different multivariate modeling methods could help in understanding the complex process relationships as a whole. The output of this study can then be used to define a control strategy to improve the quality of the PNS immediate release tablet. Keywords: Panax

  2. Severe acute cholestatic hepatitis of unknown etiology successfully treated with the Chinese herbal medicine Inchinko-to (TJ-135)

    Institute of Scientific and Technical Information of China (English)

    Susumu Ohwada; Isao Kobayashi; Nobuo Harasawa; Kyoichiro Tsuda; Yosikatsu Inui

    2009-01-01

    Severe acute hepatitis of unknown etiology is difficult to treat and often progresses to subacute fulminant hepatitis or late-onset hepatic failure. A 45-year-old wellnourished, healthy man had progressive fatigue and his liver function tests showed severe liver dysfunction. The etiology of sever acute cholestatic hepatitis was unknown. The liver function tests normalized gradually, which excluded high persistent total bilirubin after starting on predonine. A liver biopsy showed chronic active hepatitis with mild fibrosis (A2, F1). Oral Inchinko-to, a Chinese herbal medicine, at 7.5 g daily was prescribed. The treatment was effective with no adverse effects. We present a successfully treated case and discuss hepatoprotective and choleretic effects of Inchinko-to.

  3. A Chinese Herbal Preparation Containing Radix Salviae Miltiorrhizae, Radix Notoginseng and Borneolum Syntheticum Reduces Circulating Adhesion Molecules

    Directory of Open Access Journals (Sweden)

    Kylie A. O’Brien

    2011-01-01

    Full Text Available Circulating adhesion molecules (CAMs, surface proteins expressed in the vascular endothelium, have emerged as risk factors for cardiovascular disease (CVD. CAMs are involved in intercellular communication that are believed to play a role in atherosclerosis. A Chinese medicine, the “Dantonic Pill” (DP (also known as the “Cardiotonic Pill”, containing three Chinese herbal material medica, Radix Salviae Miltiorrhizae, Radix Notoginseng and Borneolum Syntheticum, has been used in China for the prevention and management of CVD. Previous laboratory and animal studies have suggested that this preparation reduces both atherogenesis and adhesion molecule expression. A parallel double blind randomized placebo-controlled study was conducted to assess the effects of the DP on three species of CAM (intercellular cell adhesion molecule-1 (ICAM-1, vascular cell adhesion molecule-1 and endothelial cell selectin (E-selectin in participants with mild-moderate hypercholesterolemia. Secondary endpoints included biochemical and hematological variables and clinical effects. Forty participants were randomized to either treatment or control for 12 weeks. Treatment with DP was associated with a statistically significant decrease in ICAM-1 (9% decrease, P = .03 and E-Selectin (15% decrease, P = .004. There was no significant change in renal function tests, liver function tests, glucose, lipids or C-reactive protein levels and clinical adverse effects did not differ between the active and the control groups. There were no relevant changes in participants receiving placebo. These results suggest that this herbal medicine may contribute to the development of a novel approach to cardiovascular risk reduction.

  4. Creating a Herbal Formula for Topical Treatment of Bone Fractures%外敷中药复方对促进骨折愈合的体外研究

    Institute of Scientific and Technical Information of China (English)

    彭丽华; 高俊熙; 萧永沁; 梁秉中

    2011-01-01

    This study aims to engineer a herbal formula under the guidance of Chinese medicine theories,then define the effective dosage ratio between the herbs and demonstrate the biological effects of the formulae on different parameters of healing using relevant in vitro assays. Six herbs which are frequently used for fractures were combined into five formulae according to the ‘ Uniform Design’ method. Assays of nitric oxide (NO) inhibition in mouse macrophages, human umbilical vein endothelial cells (HUVEC) and rat osteoblasts proliferation were used to reflect the ‘ anti-inflammation inflammatory’ , ‘ circulation promotion’ and ‘ bone formation stimulation’ functions.The results showed that all the formulae expressed significant activities of NO inhibition, and HUVEC cell and osteoblasts proliferation. Formula 5 with the largest doses (containing 30 g Radix et Rhizoma Rhei, 9 g Fructus Gardeniae, 9 g Radix et Rhizoma Notoginseng, 9 g Flos Carthami, 30 g Ramulus Sambucus Willamsii, 15 g Radix Dipsaci) demonstrated the best results in all the three assays.%目的:本课题旨在利用现代生物模型,验证中药方剂对骨折愈合的影响,为中医接骨理论提供科学依据和筛选新型方剂.方法:根据中医骨伤的组方原则,本研究从抗炎镇痛,活血化瘀和接骨续筋3类中药中各选出2味最常用的中药,采用均匀设计法将6味中药按照不同剂量配比,组成5个方剂.选择炎症因子(NO)释放、人体静脉上皮细胞(HUVEC-12)和成骨细胞(UMR-106)增殖试验分别反映抗炎镇痛,活血化瘀和接骨续筋的功效,测试各方剂对骨折愈合的影响.结果:5组复方体外试验均表现出单重或多重促进骨折愈合的作用.其中5号复方(大黄30 g,栀子、三七、红花各9 g,接骨木30 g,续断15 g)显示出全面的抑制NO释放,促进HUVEC-12和UMR-106增殖的活性.结论:证明了中药复方能从多个方面加速骨折愈合,其主效应包括抗炎镇痛,促进骨折

  5. A Novel Pharmacological Method to Study the Chinese Medicinal Formula Hua-Zheng-Hui-Sheng-Dan

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    Rui Cao

    2015-01-01

    Full Text Available Objectives. Hua-Zheng-Hui-Sheng-Dan (HZHSD was used as an experimental model to explore research methods of large formulae in traditional Chinese medicine (TCM using current molecular biology approaches. Materials and Methods. The trypan blue exclusion assay was used to determine cell viability and cell numbers. Flow cytometry was used to assess cell cycle distribution and apoptosis. The concentration of cyclin D1 was analyzed by enzyme-linked immunosorbent assay. The median effect principle was used in drug combination studies. An orthogonal experimental design was used to estimate the effects of each herb at different concentrations. The HeLa xenograft mouse model was used to compare the antitumor activity of drugs in vivo. Results. Among the 35 herbs that comprise HZHSD, Radix Rehmanniae Preparata (RRP, Caesalpinia sappan (CS, Evodia rutaecarpa (ER, Folium Artemisiae Argyi (FAA, Leonurus japonicus Houtt (LJH, Tumeric (Tu, Radix Paeoniae Alba (RPA, and Trogopterus Dung (TD effectively inhibited the proliferation of HeLa and SKOV3 cells. Only RRR had an effect on HeLa and SKOV3 cell viability. According to the median effect principle, Angelica sinensis (Oliv. (AS, Tabanus (Ta, and Pollen Typhae (PT, which were proven to have a significant synergistic inhibitory effect on the proliferation of HeLa cells, were added to the original eight positive herbs. The combination of RPA and AS had a synergistic effect on inducing cell cycle S phase arrest and decreasing intracellular cyclin D1 in HeLa cells. By orthogonal experimental design, LJH and Tu were considered unnecessary herbs. The small formula (SHZHSD consisted of RPA, AS, RRR, Ta., TD, PT, ER, CS, and FAA and was able to inhibit cell proliferation and induce cell apoptosis. The antitumor effects of HZHSD and SHZHSD were also compared in vivo. Conclusions. Through molecular biology approaches both in vitro and in vivo, research into single drugs, and analysis using the median effect principle

  6. Smart Soup, a traditional Chinese medicine formula, ameliorates amyloid pathology and related cognitive deficits.

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    Yujun Hou

    Full Text Available Alzheimer's disease (AD is a progressive neurodegenerative disease that causes substantial public health care burdens. Intensive efforts have been made to find effective and safe disease-modifying treatment and symptomatic intervention alternatives against AD. Smart Soup (SS, a Chinese medicine formula composed of Rhizoma Acori Tatarinowii (AT, Poria cum Radix Pini (PRP and Radix Polygalae (RP, is a typical prescription against memory deficits. Here, we assessed the efficacy of SS against AD. Oral administration of SS ameliorated the cognitive impairment of AD transgenic mice, with reduced Aβ levels, retarded Aβ amyloidosis and reduced Aβ-induced gliosis and neuronal loss in the brains of AD mice. Consistently, SS treatment reduced amyloid-related locomotor dysfunctions and premature death of AD transgenic Drosophila. Mechanistic studies showed that RP reduced Aβ generation, whereas AT and PRP exerted neuroprotective effects against Aβ. Taken together, our study indicates that SS could be effective against AD, providing a practical therapeutic strategy against the disease.

  7. Serum metabolomics study of Traditional Chinese medicine formula intervention to polycystic ovary syndrome.

    Science.gov (United States)

    Lu, Caixia; Zhao, Xinjie; Li, Yan; Li, Yanjie; Yuan, Chengkun; Xu, Fang; Meng, Xiaoyu; Hou, Lihui; Xu, Guowang

    2016-02-20

    Polycystic ovary syndrome (PCOS) is a most common, heterogeneous, complex endocrinopathy disease. Traditional Chinese medicine (TCM) has been used in the treatment of PCOS for many years. However, the mechanism underlying TCM remains obscure and challenging. In this study, 30 PCOS subjects were separated into normoinsulinemic group (NI=13) and hyperinsulinemic group (HI=17), and treated for three menstrual cycles with TCM Formula, Bushen Huatan Formula (BHF). A metabolomics approach based on ultra-high-performance liquid chromatography (UPLC) coupled with linear ion trap Orbi-trap mass spectrometer (LTQ Orbi-trap MS) is used to investigate serum metabolic changes of TCM intervention to PCOS. After BHF intervention for three menstrual cycles, the serum levels of glycerophosphorylethanolamine (GPEA), creatine, creatinine decreased in both NI and HI groups. Furthermore, in NI group, the main manifestation was the changes of phospholipid metabolism. While in HI group, lysine, phenol sulfate, phe-phe etc. decreased, and ornithine, proline, betaine, acetylcholine etc. increased. Combined with clinical biochemical data, BHF was proved effective to PCOS by reducing the inflammatory reaction and oxidative stress. This study also illustrates that the LC-MS based metabolomic approach is a helpful tool to evaluate curative effect and to understand the mechanisms of TCM.

  8. 优化中草药调配模式的实践研究%The Practical Research of Optimizing the Mode of the Chinese Herbal Medicine

    Institute of Scientific and Technical Information of China (English)

    马爽; 高善荣; 赵学敏

    2014-01-01

    Objective By practical research of the dispensing mode of the Chinese herbal medicine,Make sure the realistic significance and the improvement direction of the Chinese herbal medicine intelligent dispensing mode.Method By using comparative study method,compare the traditional dispensing mode and the intelligent dispensing mode.We can find that computer system technolgy,small package of the Chinese herbal pieces and the key auxiliary equipment and facilities of dispensing are the basics in the process of realizing the intelligent dispensing mode;Combined with practical work,analyse the pros and cons of the intelligent dispensing mode by using SWOT analysis method,determine the final dispensing mode of the Chinese herbal medicine of our hospital. Result and Conclusion At present,the intelligent dispensing mode of our hospital has greatly improved the administration of the dispensing mode of the Chinese herbal medicine.This is consistent with our hospital's actual work and the development direction of the administration of the dispensing mode of the Chinese herbal medicine in future.%目的:通过对我院中草药调配模式的实践研究,确证中草药智能配发模式的现实意义和改进方向。方法运用对比研究法,对传统调配模式与现行智能配发模式进行对比,指出计算机系统技术、小袋包装中药饮片、辅助调配的关键设备设施是实现智能调配模式的基础;运用SWOT分析法,结合实际工作,对智能调配模式进行优势劣势分析,最终确证我院优化中草药调配模式的途径。结果与结论目前我院采用的智能调配模式极大改善中草药调配管理,符合我院工作实际,以及当前和今后一段时期内的中草药调配管理发展方向。

  9. Beneficial Effect of Traditional Chinese Medicinal Formula Danggui-Shaoyao-San on Advanced Glycation End-Product-Mediated Renal Injury in Streptozotocin-Diabetic Rats

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    I-Min Liu

    2012-01-01

    Full Text Available The present study was undertaken to characterize the effects of Danggui-Shaoyao-San (DSS, a famous traditional Chinese medicine formula consisting of six herbal medicines, on diabetic nephropathy. Streptozotocin-induced diabetic rats were orally administrated DSS (2.8 g kg−1 per day for 12 consecutive weeks. DSS partially decreased the high plasma glucose level in diabetic rats. Diabetic-dependent alterations in urinary albumin, 24-hour urinary albumin excretion rate, and creatinine clearance as well as the kidney hypertrophy (kidney weight/body weight ratio and glomerular mesangial matrix expansion were ameliorated after 12 weeks of DSS treatment. The increased expression of nuclear factor-κB as well as transforming growth factor-β1 and the progressive accumulation of type IV collagen in kidney of diabetic rats were also attenuated by DSS. Not only the elevated levels of advanced glycation end products (AGEs and Nε-(carboxymethyllysine but also the higher levels of lipid peroxidation products in kidney of diabetic rats were ameliorated by DSS. Decreased activity of superoxide diamutase and glutathione peroxidase in kidney of diabetic rats was enhanced by DSS. These data demonstrated that the renoprotective effects of DSS in STZ-diabetic rats not only were attributable to regulate plasma glucose to attenuate AGEs expression in diabetic glomeruli but also likely reflected its antioxidant activity.

  10. Herbal Medicines for Acute Kidney Injury: Evidence, Gaps and Frontiers

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    Valérian Bunel

    2015-07-01

    Full Text Available Acute kidney injury (AKI is a major health threat worldwide. The literature on herbal intervention in AKI was searched from English and Chinese databases and reports were critically analyzed in terms of preventing AKI, promoting repair and regeneration, enhancing extrarenal clearance of uremic toxins, and preventing progression to chronic kidney disease (CKD. Altogether, 16 herbal formulae and a few extracts derived from individual herbs were reported to prevent or mitigate AKI in animal models induced by renal ischemia/reperfusion, cisplastin, gentamicin, glycerol, adenine, sepsis or physical exhaustion. Four formulae and six individual herbs were reported to accelerate recovery and/or to prevent CKD in established AKI animal models. Intrarectal herbal medicines, with or without simultaneous oral administration, were reported in six clinical trials and in an animal model to increase extrarenal clearance of uremic toxins. Additional 13 clinical trials reported oral or intravenous herbal interventions in AKI of different etiologies. Despite recurring problems, notably poor compliance with good practice guidelines for clinical trials and for authentication, naming and quality control of herbal materials, accumulating experimental data on the preventive effects of herbal medicines in AKI look encouraging and urge for better, definitive trials to guide clinical practice. Herbal enemas promoting extrarenal clearance of uremic toxins seem cost-effective, but better clinical evidence is certainly needed before any affirmative recommendation be made for AKI patients without access to dialysis. New frontiers, however, lie in those herbal remedies that promote repair/regeneration and prevent chronicity after AKI. Recent experimental data suggest that this may be possible.

  11. Protective effects of kidney-tonifying Chinese herbal preparation on substantia nigra neurons in a mouse model of Parkinson's disease

    Institute of Scientific and Technical Information of China (English)

    Jing Cai; Yun Tian; Ruhui Lin; Xuzheng Chen; Zhizhen Liu; Jindong Xie

    2012-01-01

    The Chinese herbs Herba Epimedii, Fructus Ligustri Lucidi and Rhizoma Polygonati were injected into Parkinson's disease mice established via intraperitoneal injection of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine hydrochloride. The selective monoamine oxidase B inhibitor selegiline was used as a positive control drug. After successive administration for 4 weeks, Herba Epimedii could downregulate the expression of caspase-3 and increase the brain-derived neurotrophic factor level, as well as increase tyrosine hydroxylase activity in the substantia nigra of Parkinson's disease mouse models. Rhizoma Polygonati could downregulate the expression of caspase-3 and FasL, and increase neural growth factor and brain-derived neurotrophic factor levels. Fructus Ligustri Lucidi could downregulate caspase-3 expression. Rhizoma Polygonati and Fructus Ligustri Lucidi did not produce obvious effects on tyrosine hydroxylase activity. Herba Epimedii and Fructus Ligustri Lucidi yielded similar effects on apoptosis-promoting factors to those elicited by selegiline. Herba Epimedii and Rhizoma Polygonati significantly increased the levels of neurotrophic factors compared with selegiline. Herba Epimedii significantly increased tyrosine hydroxylase activity compared with selegiline. It is indicated that the kidney-tonifying Chinese herbal preparation can downregulate the expression of apoptosis-promoting factors, increase neurotrophic factors levels in the substantia nigra and striatum, as well as increase tyrosine hydroxylase activity in the substantia nigra of Parkinson's disease mouse models, thereby exerting a stronger or similar neuroprotective effects compared with selegiline.

  12. Regulating effect of Chinese herbal medicine on the peritoneal lymphatic stomata in enhancing ascites absorption of experimental hepatofibrotic mice

    Institute of Scientific and Technical Information of China (English)

    Ji-Cheng Li; Shi-Ping Ding; Jian Xu

    2002-01-01

    AIM: To observe the regulatory effect of Chinese herbalmedicine on peritoneal lymphatic stomata and itssignificance in treating ascites in liver fibrosis model mice.METHODS: Two Chinese herbal composite prescriptionswere used separately to treat the carbon tetrachloride-induced mouse model of liver fibrosis. The histo-pathologicchanges of the liver sections (HE and VG stainings) wereobserved. The peritoneal lymphatic stomata was detected byscanning electron microscopy and computer imageprocessing. The changes of urinary volume and sodium ionconcentration were measured.RESULTS: In the model group, lots of fibrous tissue formedin liver and extended into the hepatic Iobulss to separatethem incompletely. In the treated and prevention groups,the histo-pathologic changes of liver was rather milder, onlyshowed much less fibrous tissue proliferation in the hepaticIobules. The peritoneal lymphatic stomata enlarged withincreased density in the experimental groups (diameter:PA, 3.07±0.69μm; PB, 2.82±0.37μm; TA, 3.25±0.82μmand TB, 2.82±0.56μm; density: PA, 7.11± 1.90 stomata@1000μm-2; PB, 8.76± 1.45 stomata@ 1000μm-2; TA, 6.55± 1.44 stomata@ 1000μm-2 and TB, 8.76 ± 1. 79 stomata@ 1000μm-2), as compared with the model group (diameter: 2.00 ±0.52μm; density: 4.45 ± 1. 05 stomata@ 1000 μm-2 ). Aftertreatment, the urinary volume and sodium ion excretionincreased in the experimental groupe ( PA, 231.28 ± 41. 09mmol@L-1; PB, 171.69± 27.48 mmol@L-1 and TA, 231.44±34.12 retool@ L-1 ), which were significantly different with thosein the model group (129.33 ± 36.75 rnmol@ L-1 ).CONCLUSION: Chinese herbal medicine has marked effectsin alleviating liver fibrosis, regulating peritoneal lymphaticstomata, improving the drainage of ascites from peritonealcavity and causing increase of urinary volume and sodiumion excretion to reduce the water and sodium retention, andthus have favorable therapeutic effect in treating ascites.

  13. A Chinese Herbal Decoction, Danggui Buxue Tang, Stimulates Proliferation, Differentiation and Gene Expression of Cultured Osteosarcoma Cells: Genomic Approach to Reveal Specific Gene Activation

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    Roy C. Y. Choi

    2011-01-01

    Full Text Available Danggui Buxue Tang (DBT, a Chinese herbal decoction used to treat ailments in women, contains Radix Astragali (Huangqi; RA and Radix Angelicae Sinensis (Danggui; RAS. When DBT was applied onto cultured MG-63 cells, an increase of cell proliferation and differentiation of MG-63 cell were revealed: both of these effects were significantly higher in DBT than RA or RAS extract. To search for the biological markers that are specifically regulated by DBT, DNA microarray was used to reveal the gene expression profiling of DBT in MG-63 cells as compared to that of RA- or RAS-treated cells. Amongst 883 DBT-regulated genes, 403 of them are specifically regulated by DBT treatment, including CCL-2, CCL-7, CCL-8, and galectin-9. The signaling cascade of this DBT-regulated gene expression was also elucidated in cultured MG-63 cells. The current results reveal the potential usage of this herbal decoction in treating osteoporosis and suggest the uniqueness of Chinese herbal decoction that requires a well-defined formulation. The DBT-regulated genes in the culture could serve as biological responsive markers for quality assurance of the herbal preparation.

  14. Chinese Herbal Medicine for Osteoporosis: A Systematic Review of Randomized Controlled Trails

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    Zhi-qian Wang

    2013-01-01

    Full Text Available Background. Osteoporosis is a major health problem for the elderly population. Chinese herb may be beneficial to osteoporosis due to its capability. Objectives. This study was designed to evaluate the effectiveness of Chinese medicine treatment on the patients with osteoporosis. Search Methods. Randomized controlled trials were retrieved from different 9 databases. Results. This meta analysis included 12 RCTs involving 1816 patients to compare Chinese herbs with placebo or standard anti-osteoporotic therapy in the treatment of bone loss. The pooled data showed that the percent change of increased BMD in the spine is higher with Chinese herb compared to placebo (lumber spine: WMD = 0.07, 95% CI: 0.01–0.04. In the femoral, Chinese herb showed significantly higher increments of BMD compared to placebo (femoral neck: WMD = 0.06, 95% CI: −0.02–0.13. Compared to the other standard anti-osteoporotic drugs, Chinese herbs also show advantage in BMD change (lumber spine: WMD = 0.03, 95% CI: −0.01–0.08; femoral: WMD = 0.01, 95% CI: −0.01–0.02. Conclusions. Our results demonstrated that Chinese herb significantly increased lumbar spine BMD as compared to the placebo or other standard anti-osteoporotic drugs.

  15. Herbal Medicine and Hepatocellular Carcinoma: Applications and Challenges

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    Yan Li

    2011-01-01

    Full Text Available Use of herbal medicine in the treatment of liver cancer has a long tradition. The compounds derived from the herb and herbal composites are of considerable interest among oncologists. In the past, certain herbal compounds and herbal composite formulas have been studied through in vitro and in vivo as an anti-hepatocellular carcinoma (HCC agent, enhancing our knowledge about their biologic functions and targets. However there is a significant distinction between the herbal medicine and the herbal production even though both are the plant-based remedies used in the practice. In this article, for the sake of clarity, the effective herbal compounds and herbal composite formulas against HCC are discussed, with emphasizing the basic conceptions of herbal medicine in order to have a better understanding of the prevention and treatment of HCC by herbal active compounds and herbal composite formulas.

  16. [Butanol extraction combined with dilute hydrochloric acid dissolution-atomic fluorescence spectrometric method for indirect determination of molybdenum in Chinese herbal medicine].

    Science.gov (United States)

    Lu, Jian-Ping; Geng, Guo-Xing; Tang, Yan-Kui; Lu, Zhi-Yong

    2012-12-01

    A method for indirectly determining the molybdenum in Chinese herbal medicine by butanol extraction and dilute hydrochloric acid dissolution was established for atomic fluorescence spectrometry. The molybdoarsenate heteropoly acid, formed in the presence of As(V) and ammonium molybdate in 0.3 mol x L(-1) sulphuric acid medium, was separated and enriched in the organic solvent, then the evaporation of organic reagent was implemented and the left residue was dissolved in dilute hydrochloric acid in which the arsenic content was determined on behalf of molybdenum. In the optimum experimental conditions, molybdenum content in 0-15 microg x L(-1) range depicts a good linear relationship, the detection limit and relative standard deviation of 0.44 microg x L(-1) and 1.1% were obtained, respectively. Spiked Chinese herbal medicine samples were determined with the proposed method, and recoveries of 95.6%-101.3% were achieved.

  17. 火针配合中药治疗斑秃疗效观察%Therapeutic Observation of Fire Needling plus Chinese Herbal Medicine for Alopecia Areata

    Institute of Scientific and Technical Information of China (English)

    麻秋雷; 梁冰洁; 李鹏; 赵烨; 孟凡征; 李平

    2015-01-01

    目的:观察火针配合中药治疗斑秃的临床疗效。方法将50例斑秃患者随机分为治疗组35例和对照组15例。治疗组采用火针配合中药治疗,对照组采用单纯口服中药治疗。治疗3个月后比较两组临床疗效。结果治疗组总有效率为97.1%,对照组为73.3%,两组比较差异具有统计学意义(P<0.05)。结论火针配合中药是一种治疗斑秃的有效方法。%Objective To observe the clinical efficacy of fire needling plus Chinese herbal medicine in treating alopecia areata. Method Fifty patients with alopecia areata were randomized into a treatment group of 35 cases and a control group of 15 cases. The treatment group was intervened by fire needling plus Chinese herbal medicine, while the control group was by oral administration of Chinese herbal medicine alone. The clinical efficacies were compared after 3-month treatment.Result The total effective rate was 97.1% in the treatment group versus 73.3% in the control group, and the difference was statistically significant (P<0.05).Conclusion Fire needling plus Chinese herbal medicine is an effective method in treating alopecia areata.

  18. A New Furostanol Saponin from the Water-extract of Dioscorea nipponica Mak., the Raw Material of the Traditional Chinese Herbal Medicine Wei Ao Xin

    Institute of Scientific and Technical Information of China (English)

    Cheng Bin CUI; Chi XU; Qian Qun GU; Shi Dong CHU; Hai Hong JI; Gang JING

    2004-01-01

    26-O-β-D-Glucopyranosyl-furost-5(6),20(22)-dien-3β,26-diol 1, a new furostanol saponin, was isolated from the water-extract of Dioscorea nipponica Mak., the raw material of a traditional Chinese herbal medicine Wei Ao Xin. The structure of 1 was determined on the basis of its spectral data especially by NMR spectroscopy. The result provides the first example of naturally occurring furostanol saponins with a single saccharide chain at the C-26 position.

  19. Analysis of Sheng-Mai-San, a Ginseng-Containing Multiple Components Traditional Chinese Herbal Medicine Using Liquid Chromatography Tandem Mass Spectrometry and Physical Examination by Electron and Light Microscopies.

    Science.gov (United States)

    Cheng, Yung-Yi; Tsai, Tung-Hu

    2016-09-01

    Sheng-Mai-San is a multi-component traditional Chinese herbal preparation. Due to the fact granulated additives, such as starch, carboxymethyl cellulose, lactose and raw herbal powder may alter the content of the bioactive markers in the herbal products, a developed ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method was used to measure the herbal biomarkers of ginsenoside Rb₁, Rb₂, Rc, Rd, Re, Rg₁, Rh₁, compound K, ophiopogonin D and schizandrin from the Sheng-Mai-San herbal formulation. Besides, scanning electron microscopy (SEM) was used to observe the morphology of the herbal granular powders. Light microscopy with Congo red and iodine-KI reagent staining was used to identify the cellulose fiber and cornstarch added to pharmaceutical herbal products. The swelling power (SP), water solubility index (WSI), and crude fiber analysis were used to determine the contents of cellulose fiber and cornstarch in pharmaceutical herbal products. In this study, we developed a novel skill to assess the quantification of appended cornstarch in pharmaceutical herbal products using Aperio ImageScope software. Compared with the traditional cornstarch analysis, our analysis method is a rapid, simple and conversion process which could be applied to detect the percentage of added cornstarch in unknown powder products. The various range of the herbal content for the five pharmaceutical manufacturers varied by up to several hundreds-fold. The physical examination reveals that the morphology of the herbal pharmaceutical products is rough and irregular with sharp layers. This study provides a reference standard operating procedure guide for the quality control of the Chinese herbal pharmaceutical products of Sheng-Mai-San.

  20. Study on the Effect of Chinese Herbal Medicine in Regulating Peritoneal Lymphatic Stomata and Enhancing Drainage of Ascites in Mice with Liver Fibrosis

    Institute of Scientific and Technical Information of China (English)

    李继承; 袁淑慧; 赵坚培; 吕志连

    2001-01-01

    Objective: To observe the regulating effect of Chinese herbal medicine on peritoneal lymphatic stomata and its significance in treating ascites in liver fibrosis model mice. Methods: Two Chinese herbal compound prescriptions were used separately to treat the carbon tetrachloride induced mouse model of liver fibrosis, the histo-pathologic changes in mice were observed by using scanning electron microscope and processed by computer image processing. The changes of urinary volume and sodium ion concentration were measured, too.Results: In the treated group, the histo-pathologic changes were significantly less than those in the control group, the peritoneal lymphatic stomata enlarged with increased number of opening and higher density in distribution and the urinary volume and sodium ion excretion increased after treatment. Conclusion: Chinese herbal medicine has marked effect in alleviating liver fibrosis, regulating peritoneal lymphatic stomata, improving the drainage of ascites from peritoneal cavity, causing increase of urinary volume and sodium ion excretion to reduce water and sodium retention, and thus have favorable therapeutic effect in treating ascites.

  1. Effect of Chinese Herbal Medicinal Ingredients on IL-2 mRNA Levels of T Lymphocytes in Mice Measured Using Semiquantification RT-PCR

    Institute of Scientific and Technical Information of China (English)

    CHU Yue-feng; YAN Xin-min; LI Xiang-rui; HU Yuan-liang

    2006-01-01

    In this study, the IL-2 mRNA levels of T lymphocytes in normal mice stimulated by nine Chinese herbal medicinal ingredients (CHMIs) were measured using semiquantification reverse transcription polymerase chain reaction. The results showed that astragalus polysaccharide (APS), epimedium polysaccharide (EPS), Chinese angelica polysaccharide (CAPS), propolis flavone (PF), and astrogalosides (AS) promoted IL-2 mRNA levels in T lymphocytes in vitro and in vivo to differing degrees, and the level of IL-2 mRNA induced by propolis polysaccharide (PPS) in vitro was higher than that induced by the control, which differed from that of PPS in vivo.

  2. Dangkwisoo-san, an herbal medicinal formula, ameliorates acute lung inflammation via activation of Nrf2 and suppression of NF-κB

    Science.gov (United States)

    Lyu, Ji Hyo; Kim, Kyun Ha; Kim, Hyung Woo; Cho, Su-In; Ha, Ki-Tae; Choi, Jun-Yong; Han, Chang Woo; Jeong, Han-Sol; Lee, Hyeong-Kyu; Ahn, Kyung-Seop; Oh, Sei-Ryang; Sadikot, Ruxana T.; Christman, John W.; Joo, Myungsoo

    2013-01-01

    Ethnopharmacological relevance Dangkwisoo-san (DS), an herbal medicinal formula, has long been used in Korea for the treatment of inflammatory complications caused by physical trauma. Although the therapeutic effect of DS is likely associated with anti-inflammatory activity, the precise underlying mechanisms are largely unknown. Here we sought to elucidate the possible mechanisms of anti-inflammatory activity of DS. Materials and Methods The water extract of DS was orally fed to C57BL/6 mice for 14 days prior to LPS intranasal instillation for lung inflammation. The effects of DS on lung inflammation were determined by differential cell counting, lung histology, and semi-quantitative RT-PCR of lung sections. The effects of DS on the activities of Nrf2 and NF-κB were assessed by western blotting, semi-quantitative RT-PCR, and luciferase reporter assays in RAW 264.7, an NF-κB reporter cell line, and HEK 293 transfected with an NF-κB reporter construct. Results Mice that were treated with a water extract of DS showed significant attenuation of lung inflammation induced by intranasal lipopolysaccharide (LPS) compared to control mice treated with vehicle. In vitro experiments show that DS activated Nrf2, an anti-oxidant transcription factor that protects from various inflammatory diseases, and inducedNrf2-regulated genes including GCLC, NQO-1 and HO-1. In addition, DS suppressed NF-κB activity and reduced the production of pro-inflammatory cytokines. Transfection experiment indicates that inhibition of NF-κB likely occurred upstream of IKK complex. Furthermore, DS enhanced the expression of HO-1 and suppressed that of IL-1β and TNF-α in inflamed mouse lungs. Conclusions These results suggest that the therapeutic effects of DS are related with suppression of inflammation, which is, at least in part, mediated by activation of anti-inflammatory factor Nrf2 and inhibition of pro-inflammatory factor NF-κB. PMID:22230470

  3. Optimizing Prescription of Chinese Herbal Medicine for Unstable Angina Based on Partially Observable Markov Decision Process

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    Yan Feng

    2013-01-01

    Full Text Available Objective. Initial optimized prescription of Chinese herb medicine for unstable angina (UA. Methods. Based on partially observable Markov decision process model (POMDP, we choose hospitalized patients of 3 syndrome elements, such as qi deficiency, blood stasis, and turbid phlegm for the data mining, analysis, and objective evaluation of the diagnosis and treatment of UA at a deep level in order to optimize the prescription of Chinese herb medicine for UA. Results. The recommended treatment options of UA for qi deficiency, blood stasis, and phlegm syndrome patients were as follows: Milkvetch Root + Tangshen + Indian Bread + Largehead Atractylodes Rhizome (ADR=0.96630; Danshen Root + Chinese Angelica + Safflower + Red Peony Root + Szechwan Lovage Rhizome Orange Fruit (ADR=0.76; Snakegourd Fruit + Longstamen Onion Bulb + Pinellia Tuber + Dried Tangerine peel + Largehead Atractylodes Rhizome + Platycodon Root (ADR=0.658568. Conclusion. This study initially optimized prescriptions for UA based on POMDP, which can be used as a reference for further development of UA prescription in Chinese herb medicine.

  4. Optimizing prescription of chinese herbal medicine for unstable angina based on partially observable markov decision process.

    Science.gov (United States)

    Feng, Yan; Qiu, Yu; Zhou, Xuezhong; Wang, Yixin; Xu, Hao; Liu, Baoyan

    2013-01-01

    Objective. Initial optimized prescription of Chinese herb medicine for unstable angina (UA). Methods. Based on partially observable Markov decision process model (POMDP), we choose hospitalized patients of 3 syndrome elements, such as qi deficiency, blood stasis, and turbid phlegm for the data mining, analysis, and objective evaluation of the diagnosis and treatment of UA at a deep level in order to optimize the prescription of Chinese herb medicine for UA. Results. The recommended treatment options of UA for qi deficiency, blood stasis, and phlegm syndrome patients were as follows: Milkvetch Root + Tangshen + Indian Bread + Largehead Atractylodes Rhizome (ADR = 0.96630); Danshen Root + Chinese Angelica + Safflower + Red Peony Root + Szechwan Lovage Rhizome Orange Fruit (ADR = 0.76); Snakegourd Fruit + Longstamen Onion Bulb + Pinellia Tuber + Dried Tangerine peel + Largehead Atractylodes Rhizome + Platycodon Root (ADR = 0.658568). Conclusion. This study initially optimized prescriptions for UA based on POMDP, which can be used as a reference for further development of UA prescription in Chinese herb medicine.

  5. Antinociceptive and Anti-inflammatory Activities of a Chinese Herbal Recipe (DJW in Animal Models

    Directory of Open Access Journals (Sweden)

    P Kunanusorn

    2009-03-01

    Full Text Available Summary: Since in our previous study, Duhuo Jisheng Wan (DJW, which means pill of pubescent angelica root and mulberry mistletoe combination, demonstrates clinically comparable efficacy to diclofenac in the symptomatic treatment of osteoarthritis (OA of the knee after 4 weeks of treatment.  Therefore, in order to verify its mechanisms of action, this study was performed to investigate the antinociceptive and anti-inflammatory activities of DJW in various animal models.  The antinociceptive activity of DJW was investigated by using the formalin test in mice model.  The acute inflammatory model using the carrageenin-induced hind paw edema in rats and the chronic inflammatory model using the cotton pellet-induced granuloma formation in rats were utilized.  Results showed that DJW possessed a marked antinociceptive activity in both phases of the formalin test in mice.  However, in the carrageenin-induced hind paw edema model, which is known to be sensitive to cyclooxygenase (COX inhibitors, DJW showed an insignificant anti-inflammatory effect, and in the cotton pellet-induced granuloma model, it had no antigranuloma formation and showed no effect on the transudate weight.  In addition, DJW showed no suppressive effects on weight gain and the thymus weight of the rats.  In conclusion, the overall results demonstrate that DJW possess both central and peripheral antinociceptive activities.  However, its anti-inflammatory activity, if any, could not be demonstrated in these two inflammatory models in the present study and remains to be elucidate.   Industrial relevance: Since drug therapy in OA patients, such as paracetamol, non-steroidal anti-inflammatory drugs (NSAIDs, and topical analgesics may prove ineffective in some patients, and long-term therapy with NSAIDs often have been associated with serious adverse effects.  Such patients are turning increasingly to herbal medicines and DJW may be an alternative since it demonstrates clinically

  6. Clinical efficacy and safety of Chinese herbal medicine for Wilson's disease: a systematic review of 9 randomized controlled trials.

    Science.gov (United States)

    Wang, Yan; Xie, Cheng-long; Fu, Deng-lei; Lu, Lin; Lin, Yan; Dong, Qi-qian; Wang, Xiao-tong; Zheng, Guo-qing

    2012-06-01

    Wilson's disease is an autosomal recessive disorder of copper metabolism. Despite being treatable, there is no universally accepted treatment regimen. Currently, various Chinese herbal medicines (CHMs) are widely used in the treatment of Wilson's disease in China, but there is a lack of reliable scientific evidence for the effectiveness of such therapies. The objective of this systematic review is to assess the clinical efficacy and safety of CHM as an alternative or/and adjuvant therapy for Wilson's disease. A systematic literature search in different medical databases was performed to identify randomized controlled trials comparing CHM as monotherapy or CHM as adjuvant therapy with western conventional medical therapy in the treatment of Wilson's disease. A total of 687 participants were included in nine eligible studies. The main findings are that CHM as monotherapy or adjuvant therapy for Wilson's disease may be able to improve the clinical symptoms, to promote the urinary copper excretion, to ameliorate liver function and/or liver cirrhosis, and has fewer adverse effects in comparison with western conventional medication. Furthermore, CHM generally appeared to be safe and well tolerated in patients with Wilson's disease. However, the evidence presented in this review are insufficient to warrant a clinical recommendation due to the generally low methodological quality of the included studies. In conclusion, CHM seems to be beneficial and safe for Wilson's disease, but high-quality evidences are still needed to further evaluate this therapy. Therefore, additional well-designed, randomized, placebo-controlled clinical trials are needed.

  7. Transport and metabolism of flavonoids from Chinese herbal remedy Xi-aochaihu-tang across human intestinal Caco-2 cell monolayers

    Institute of Scientific and Technical Information of China (English)

    Jie-yu DAI; Jun-ling YANG; Chuan LI

    2008-01-01

    Aim:To investigate the limiting factors for oral bioavailability of flavonoids derived from the Chinese herbal remedy Xiaochaihu-tang. The investi-gational flavonoids included baicalin, wogonoside, oroxylin-A 7-O-β-D-glucopyranosiduronide, liquiritin, liquiritin apioside, isoliquiritin, and isoliquiri-tin apioside, as well as their aglycones baicalein, wogonin, oroxylin-A, liquir-itigenin, and isoliquiritigenin. Methods: Caco-2 cell monolayers were used and the apparent permeability both in apical to basolateral and basolateral to apical directions was measured for each investigational compound. Meanwhile, chemoinformatics was carried out to provide insight into the mechanism govern-ing the permeability. In addition, carrier-mediated transport with or without in-hibitors, as well as the metabolism by conjugation, was also examined with Ca-co-2 cell monolayers for the flavonoids. Results: The investigational flavonoid aglycones exhibited favorable membrane permeability, but efficient glucuronida-tion and/or sulfation by the enterocytes may limit their bioavailability. For the flavonoid glycosides, their poor membrane permeability was found to be caused by high hydrogen-bonding potential. Among the glycosides, oroxylin-A 7-O-β-D-glucopyranosiduronide, isoliquiritin, and isoliquiritin apioside were transport-ed under the mediation of the efflux transporters multidrug resistance-associated protein and/or P-glycoprotein. Conclusion: The limiting factors of oral bioavail-ability for the flavonoids derived from Xiaochaihu-tang appeared to include poor membrane permeability, significant effiux, and efficient intestinal metabolism by conjugation.

  8. Separation and determination of four active anthraquinones in Chinese herbal preparations by flow injection-capillary electrophoresis.

    Science.gov (United States)

    Liu, Lihong; Fan, Liuyin; Chen, Hongli; Chen, Xingguo; Hu, Zhide

    2005-08-01

    A simple, rapid, and accurate method for the separation and determination of physcion, chrysophanol, aloe-emodin, and emodin in Rhubarb, Juemingzi, and Chinese herbal preparations was developed by combination of flow injection-capillary zone electrophoresis for the first time. The analysis was carried out using an unmodified fused-silica capillary (75 mm x 50 microm ID x 375 microm OD, effective separation length of 48 mm) and direct ultraviolet detection at 254 nm. By a series of optimization, the sample solvent consisted of NaOH (100 mmol/L) and ACN (1:1 v/v), and a running buffer composed of 15 mmol/L sodium borate - 12.5 mmol/L sodium dihydrogen phosphate - 42% v/v ACN (pH 10.1) was applied for the separation of the four anthraquinones. The separation was rapid and highly reproducible, with complete resolution of all four compounds within 6 min. The sample throughput rate could reach up to 12 per h. The repeatability (defined as relative standard deviation) was 4.45, 4.44, 4.34, 0.61% with peak height evaluation and 1.62, 0.89, 2.49, 2.19% with peak area evaluation for physcion, chrysophanol, aloe-emodin, and emodin, respectively.

  9. Chinese Herbal Medicines as an Adjunctive Therapy for Unresectable Pancreatic Cancer: A Systematic Review and Meta-Analysis

    Directory of Open Access Journals (Sweden)

    Bin Li

    2015-01-01

    Full Text Available Pancreatic cancer is a common malignancy with a high mortality. Most patients present clinically with advanced pancreatic cancer. Moreover, the effect of radiotherapy or chemotherapy is limited. Complementary and alternative medicines represent exciting adjunctive therapies. In this study, we ascertained the beneficial and adverse effects of Chinese herbal medicine (CHM in combination with conventional therapy for inoperable pancreatic cancer by using meta-analysis methods for controlled clinical trials. We extracted data for studies searched from six electronic databases that were searched and also assessed the methodological quality of the included studies. We evaluated the following outcome measures: 6-month and 1-year survival rate, objective response rate, disease control rate, quality of life, and adverse effects. The final analysis showed CHM is a promising strategy as an adjunctive therapy to treat advanced or inoperable pancreatic cancer and that CHM in combination with conventional therapy is a promising strategy for resistant disease. However, convincing evidence must be obtained and confirmed by high-quality trials in future studies.

  10. Clinical Study on Treatment of Non-small Cell Lung Cancer by Chinese Herbal Medicine Combined with Bronchial Arterial Chemotherapy

    Institute of Scientific and Technical Information of China (English)

    刘城林; 王远东; 金学军; 刘丽萍; 喻庆薇; 蔡悦成

    2001-01-01

    To study the therapeutic effect of Chinese herbal medicine (CHM) combined with bronchial arterial chemotherapy (BAC) in treating lung cancer.Methods: Ninety patients with mid-advanced non-small cell lung cancer (NSCLC) were randomly divided into two groups. The 45 cases in Group A were treated with CHM combined with BAC and the 45 cases in Group B treated with BAC alone. The short-term and long-term effect, follow-up survival rate, quality of life, changes of clinical symptoms and peripheral blood figures in the patients were observed.Results: After treatment, the rate of CR+PR+NC in the two groups was 88.89% and 68.89% respectively, the inter-group comparison showed a significant difference (P<0.05). The 0.5-, 1- and 2-year survival rate in Group A was 75.56%, 55.56% and 48.89% respectively and in Group B 71.11%, 46.67% and 24.44% respectively. The 2-year survival rate in the former was better than that in the latter (P<0.05). Moreover, the improvement of clinical symptoms, Karnofsky scoring, body weight and peripheral blood figure in Group A was superior to those in Group B.Conclusion: Therapeutic effect of BAC could be enhanced by combining it with CHM.

  11. Diversity of Pharmacological Properties in Chinese and European Medicinal Plants: Cytotoxicity, Antiviral and Antitrypanosomal Screening of 82 Herbal Drugs

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    Thomas Efferth

    2011-09-01

    Full Text Available In an extensive screening, the antiviral, antitrypanosomal and anticancer properties of extracts from 82 plants used in traditional Chinese medicine and European phytomedicine were determined. Several promising plants that were highly effective against hepatitis B virus (HBV, bovine viral diarrhoea virus (BVDV—a flavivirus used here as a surrogate in vitro model of hepatitis C virus, trypanosomes (Trypanosoma brucei brucei and several cancer cell lines were identified. Six aqueous extracts from Celosia cristata, Ophioglossum vulgatum, Houttuynia cordata, Selaginella tamariscina, Alpinia galanga and Alpinia oxyphylla showed significant antiviral effects against BVDV without toxic effects on host embryonic bovine trachea (EBTr cells, while Evodia lepta, Hedyotis diffusa and Glycyrrhiza spp. demonstrated promising activities against the HBV without toxic effects on host human hepatoblastoma cells transfected with HBV-DNA (HepG2 2.2.15 cells. Seven organic extracts from Alpinia oxyphylla, Coptis chinensis, Kadsura longipedunculata, Arctium lappa, Panax ginseng, Panax notoginseng and Saposhnikovia divaricata inhibited T. b. brucei. Moreover, among fifteen water extracts that combined high antiproliferative activity (IC50 0.5–20 µg/mL and low acute in vitro toxicity (0–10% reduction in cell viability at IC50, Coptis chinensis presented the best beneficial characteristics. In conclusion, traditional herbal medicine from Europe and China still has a potential for new therapeutic targets and therapeutic applications.

  12. Enhanced Bone Tissue Regeneration by Porous Gelatin Composites Loaded with the Chinese Herbal Decoction Danggui Buxue Tang.

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    Wen-Ling Wang

    Full Text Available Danggui Buxue Tang (DBT is a traditional Chinese herbal decoction containing Radix Astragali and Radix Angelicae sinensis. Pharmacological results indicate that DBT can stimulate bone cell proliferation and differentiation. The aim of the study was to investigate the efficacy of adding DBT to bone substitutes on bone regeneration following bone injury. DBT was incorporated into porous composites (GGT made from genipin-crosslinked gelatin and β-triclacium phosphates as bone substitutes (GGTDBT. The biological response of mouse calvarial bone to these composites was evaluated by in vivo imaging systems (IVIS, micro-computed tomography (micro-CT, and histology analysis. IVIS images revealed a stronger fluorescent signal in GGTDBT-treated defect than in GGT-treated defect at 8 weeks after implantation. Micro-CT analysis demonstrated that the level of repair from week 4 to 8 increased from 42.1% to 71.2% at the sites treated with GGTDBT, while that increased from 33.2% to 54.1% at GGT-treated sites. These findings suggest that the GGTDBT stimulates the innate regenerative capacity of bone, supporting their use in bone tissue regeneration.

  13. Effectiveness of Chinese herbal medicine for cancer palliative care: overview of systematic reviews with meta-analyses.

    Science.gov (United States)

    Chung, Vincent C H; Wu, Xinyin; Hui, Edwin P; Ziea, Eric T C; Ng, Bacon F L; Ho, Robin S T; Tsoi, Kelvin K F; Wong, Samuel Y S; Wu, Justin C Y

    2015-01-01

    Chinese herbal medicines (CHM) are often used in managing cancer related symptoms but their effectiveness and safety is controversial. We conducted this overview of meta-analyses to summarize evidence on CHM for cancer palliative care. We included systematic reviews (SRs) with meta-analyses of CHM clinical trials on patients diagnosed with any type of cancer. Methodological quality of included meta-analyses was assessed with the Methodological Quality of Systematic Reviews (AMSTAR) Instrument. Fifty-one SRs with meta-analyses were included. They covered patients with lung (20 SRs), gastric (8 SRs), colorectal (6 SRs), liver (6 SRs), breast (2 SRs), cervical (1 SR), esophageal (1 SR), and nasopharyngeal (1 SR) cancers. Six SRs summarized evidence on various types of cancer. Methodological quality of included meta-analyses was not satisfactory. Overall, favorable therapeutic effects in improving quality of life among cancer patients have been reported. Conflicting evidence exists for the effectiveness of CHM in prolonging survival and in reducing chemotherapy and/or radiotherapy related toxicities. No serious adverse effects were reported in all included studies. Evidence indicated that CHM could be considered as an option for improving quality of life among patients receiving palliative care. It is unclear if CHM may increase survival, or reduce therapy related toxicities.

  14. Anti-endotoxin and anti-inflammatory effects of Chinese herbal medicinal alkaloid ingredients in vivo.

    Science.gov (United States)

    Hu, Yiyi; Mao, Aihua; Yu, Zhengyu; He, Kongwang

    2016-10-01

    The aim of the research was to investigate the anti-endotoxin and anti-inflammatory effects of sinomenine, fangchinoline, stachydrine, chuanxionggzine, oxymartrine, and evodiamine alkaloids commonly found in Chinese herbal medicines. In an endotoxin (LPS) control group, each mouse was challenged with 1 mg LPS/kg by intraperitoneal (IP) injection. In high-, middle- and low-dose alkaloid groups, mice were initially challenged with 1 mg LPS/kg by IP injection and, 3 h later, dosed intramuscularly (IM) with one of the six alkaloids at one of three levels (1, 5, or 10 mg/kg body weight). In the drug control group, mice were dosed IM with 10 mg/kg body weight of a given alkaloid; mice in a naïve control group were administered the same volume of normal saline. The results revealed the six alkaloids could reduce the incidence/severity of LPS- induced toxicities, e.g., body temperature elevation, weight loss, systemic inflammation, multiple organ dysfunction. Taken together, the data suggested to us that these alkaloids might effectively regulate inflammatory responses and have a potential to be used in anti-endotoxin therapies.

  15. Radix Astragali-Based Chinese Herbal Medicine for Oxaliplatin-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis

    Science.gov (United States)

    2016-01-01

    Background. Treatment of chemotherapy-induced peripheral neuropathy (CIPN) remains a big challenge for oncologists. The aim of this study is to evaluate the effects of Radix Astragali- (RA-) based Chinese herbal medicine in the prevention and treatment of oxaliplatin-induced peripheral neuropathy, including the incidence and grading of neurotoxicity, effective percentage, and nerve conduction velocity. Methods. All randomized controlled trials (RCTs) were found using PubMed, Cochrane, Springer, China National Knowledge Infrastructure (CNKI), and Wanfang Database of China Science Periodical Database (CSPD) by keyword search. Meta-analysis was conducted using RevMan 5.0. Results. A total of 1552 participants were included in 24 trials. Meta-analysis showed the incidence of all-grade neurotoxicity was significantly lower in experimental groups and high-grade neurotoxicity was also significantly less. Effective percentage was significantly higher and sensory nerve conduction velocity was improved significantly, but changes in motor nerve conduction velocity were not statistically significant. No adverse events associated with RA-based intervention were reported. Conclusion. RA-based intervention may be beneficial in relieving oxaliplatin-induced peripheral neuropathy. However, more double-blind, multicenter, large-scale RCTs are needed to support this theory. Trial Registration. PROSPERO International prospective register of systematic reviews has registration number  CRD42015019903.

  16. Ancient Records and Modern Research on the Mechanisms of Chinese Herbal Medicines in the Treatment of Diabetes Mellitus

    Directory of Open Access Journals (Sweden)

    Hai-ming Zhang

    2015-01-01

    Full Text Available Over the past decades, Chinese herbal medicines (CHM have been extensively and intensively studied through from both clinical and experimental perspectives and CHM have been proved to be effective in the treatment of diabetes mellitus (DM. This study, by searching ancient records and modern research papers, reviewed CHM in terms of their clinical application and principal mechanism in the treatment of DM. We summarized the use of CHM mentioned in 54 famous ancient materia medica monographs and searched papers on the hypoglycemic effect of several representative CHM. Main mechanisms and limitations of CHM and further research direction for DM were discussed. On the basis of the study, we were led to conclude that TCM, as a main form of complementary and alternative medicine (CAM, was well recorded in ancient literatures and has less adverse effects as shown by modern studies. The mechanisms of CHM treatment of DM are complex, multilink, and multitarget, so we should find main hypoglycemic mechanism through doing research on CHM monomer active constituents. Many CHM monomer constituents possess noteworthy hypoglycemic effects. Therefore, developing a novel natural product for DM and its complications is of much significance. It is strongly significant to pay close attention to CHM for treatment of DM and its complications.

  17. Statistical modeling methods to analyze the impacts of multiunit process variability on critical quality attributes of Chinese herbal medicine tablets.

    Science.gov (United States)

    Sun, Fei; Xu, Bing; Zhang, Yi; Dai, Shengyun; Yang, Chan; Cui, Xianglong; Shi, Xinyuan; Qiao, Yanjiang

    2016-01-01

    The quality of Chinese herbal medicine tablets suffers from batch-to-batch variability due to a lack of manufacturing process understanding. In this paper, the Panax notoginseng saponins (PNS) immediate release tablet was taken as the research subject. By defining the dissolution of five active pharmaceutical ingredients and the tablet tensile strength as critical quality attributes (CQAs), influences of both the manipulated process parameters introduced by an orthogonal experiment design and the intermediate granules' properties on the CQAs were fully investigated by different chemometric methods, such as the partial least squares, the orthogonal projection to latent structures, and the multiblock partial least squares (MBPLS). By analyzing the loadings plots and variable importance in the projection indexes, the granule particle sizes and the minimal punch tip separation distance in tableting were identified as critical process parameters. Additionally, the MBPLS model suggested that the lubrication time in the final blending was also important in predicting tablet quality attributes. From the calculated block importance in the projection indexes, the tableting unit was confirmed to be the critical process unit of the manufacturing line. The results demonstrated that the combinatorial use of different multivariate modeling methods could help in understanding the complex process relationships as a whole. The output of this study can then be used to define a control strategy to improve the quality of the PNS immediate release tablet.

  18. A yang-promoting Chinese herbal suppository preparation enhances the antioxidant status of red cells in male human subjects.

    Science.gov (United States)

    Mak, D H F; Chiu, P Y; Poon, M K T; Ng, T T L; Chung, Y K; Lam, B Y H; Du, Y; Ko, K M

    2004-07-01

    In the 16-week pilot study, the effect of a Yang-promoting Chinese herbal suppository preparation (VI-28) on the red cell antioxidant status was examined in 31 healthy male subjects aged 41-66 years old. VI-28 treatment for 12 weeks (one suppository (0.3 g) daily for week 1-4; one every 2 days for week 5-8; one every 3 days for week 9-12) produced a time/dose-dependent alteration in red cell antioxidant status. The VI-28-induced change is characterized by a slight depletion in cellular reduced glutathione (GSH) level and a decrease in susceptibility to peroxide-induced lipid peroxidation as well as increases in catalase (CAT) and Cu-Zn-superoxide dismutase (SOD) activities. While a reversal trend of change was observed in cellular GSH level, the susceptibility to lipid peroxidation as well as the CAT activity after the cessation of treatment for 4 weeks, the SOD activity exhibited a protracted increase. The results indicate that VI-28 treatment enhances red cell antioxidant status in male subjects. The beneficial effect of VI-28 treatment on red cells may re fl ect a corresponding change in antioxidant status of peripheral tissues.

  19. Evaluation of humic substances during co-composting of food waste, sawdust and Chinese medicinal herbal residues.

    Science.gov (United States)

    Zhou, Ying; Selvam, Ammaiyappan; Wong, Jonathan W C

    2014-09-01

    Humification during co-composting of food waste, sawdust and Chinese medicinal herbal residues (CMHRs) was investigated to reveal its correlation with compost maturity. Food waste, sawdust and CMHRs were mixed at 5:5:1 and 1:1:1 (dry weight basis) while food waste:sawdust at 1:1 (dry wt. basis) served as control. Lime at 2.25% was added to all the treatments to alleviate low pH, and composted for 56 days. Humic acid/fulvic acid (HA/FA) ratio increased to 0.5, 2.0 and 3.6 in the control and treatment at 5:5:1, and 1:1:1 mixing ratio, respectively at the end of composting. The decrease in aliphatic organics in HA demonstrated the degradation of the readily available organics, while an increase in aromatic functional groups indicated the maturity of compost. Disappearance of hemicellulose and weak intensity of lignin in the CMHRs treatments indicated that the lignin provided the nucleus for HA formation; and the CMHRs accelerated the compost maturity.

  20. Regulation of human pregnane X receptor and its target gene cytochrome P450 3A4 by Chinese herbal compounds and a molecular docking study.

    Science.gov (United States)

    Liu, Ya-He; Mo, Sui-Lin; Bi, Hui-Chang; Hu, Bing-Fang; Li, Chun Guang; Wang, Yi-Tao; Huang, Ling; Huang, Min; Duan, Wei; Liu, Jun-Ping; Wei, Ming Qian; Zhou, Shu-Feng

    2011-04-01

    The pregnane X receptor (PXR) plays a critical role in the regulation of human cytochrome P450 3A4 (CYP3A4) gene. In this study, we investigated the effect of an array of compounds isolated from Chinese herbal medicines on the activity of PXR using a luciferase reporter gene assay in transiently transfected HepG2 and Huh7 cells and on the expression of PXR and CYP3A4 in LS174T cells. Furthermore, molecular docking was performed to investigate the binding modes of herbal compounds with PXR. Praeruptorin A and C, salvianolic acid B, sodium danshensu, protocatechuic aldehyde, cryptotanshinone, emodin, morin, and tanshinone IIA significantly transactivated the CYP3A4 reporter gene construct in either HepG2 or Huh7 cells. The PXR mRNA expression in LS174T cells was significantly induced by physcion, protocatechuic aldehyde, salvianolic acid B, and sodium danshensu. However, epifriedelanol, morin, praeruptorin D, mulberroside A, tanshinone I, and tanshinone IIA significantly down-regulated the expression of PXR mRNA in LS174T cells. All the herbal compounds tested can be readily docked into the ligand-binding cavity of PXR mainly through hydrogen bond and aromatic interactions with Ser247, Gln285, His407, and Arg401. These findings suggest that herbal medicines can significantly regulate PXR and CYP3A4 and this has important implication in herb-drug interactions.

  1. 基于均匀设计的中药有效组分复方配伍研究%Uniform designed research on the active ingredients assembling of Chinese herbal for antioxidative capacity

    Institute of Scientific and Technical Information of China (English)

    杨鸿; 吴彦; 马琰岩; 吕俊海; 李晶哲

    2012-01-01

    Objective To find a suitable way of quantitative composition-activity relationship of Chinese herbal for antioxidative capacity based on uniform design. Method Chinese herbal active ingredient formula was composed of Total flavonoids of Glycyrrhiza (TFG) , ginkgo biloba extract (GBE) , Total fa-vonoids of epimedium (TFE) and astragaloside (AST) . The herbal efficacy was detected by scavenging the free radical of DPPH in vitro, and the mathematical model was constructed to describe the connection between different combinations and their antioxidative capacity by the method of LARS regression. Result The best effect was in the ratio of TFG 0. 8 mg/ml,GBE 3.144 mg/ml,TFE 0.024 mg/ml,AST 0.036 mg/ml. Conclusion Uniform designed research is one of efficient ways to describe the quantitative composition-activity relationship.%目的 探索基于均匀设计的中药抗氧化有效组分复方的研究分析方法.方法 采用均匀设计和改进最小角回归分析,对甘草总黄酮、银杏叶提取物、淫羊藿总黄酮和黄芪总苷组成的中药组分复方不同配比体外清除DPPH自由基的作用进行研究.结果 通过分析获得了中药组分配伍清除DPPH的回归方程,优化组合后进行药效学验证,结果显示该中药组分配伍最佳剂量组合为甘草总黄酮0.8 mg/ml、银杏叶提取物3.144 mg/ml、淫羊藿总黄酮0.024 mg/ml和黄芪总苷0.036 mg/ml.结论 上述中药组分配伍后能有效清除DPPH自由基;本实验采用的均匀设计结合改进最小角回归分析适合"非线性、小样本"生物实验数据数据分析,为筛选评价抗氧化中药有效组分复方提供了合适的研究方法.

  2. High-performance liquid chromatography coupled with tandem mass spectrometry technology in the analysis of Chinese Medicine Formulas: A bibliometric analysis (1997-2015).

    Science.gov (United States)

    He, Xi-Ran; Li, Chun-Guang; Zhu, Xiao-Shu; Li, Yuan-Qing; Jarouche, Mariam; Bensoussan, Alan; Li, Ping-Ping

    2017-01-01

    There is a recognized challenge in analyzing traditional Chinese medicine formulas because of their complex chemical compositions. The application of modern analytical techniques such as high-performance liquid chromatography coupled with a tandem mass spectrometry has improved the characterization of various compounds from traditional Chinese medicine formulas significantly. This study aims to conduct a bibliometric analysis to recognize the overall trend of high-performance liquid chromatography coupled with tandem mass spectrometry approaches in the analysis of traditional Chinese medicine formulas, its significance and possible underlying interactions between individual herbs in these formulas. Electronic databases were searched systematically, and the identified studies were collected and analyzed using Microsoft Access 2010, Graph Pad 5.0 software and Ucinet software package. 338 publications between 1997 and 2015 were identified, and analyzed in terms of annual growth and accumulated publications, top journals, forms of traditional Chinese medicine preparations and highly studied formulas and single herbs, as well as social network analysis of single herbs. There is a significant increase trend in using high-performance liquid chromatography coupled with tandem mass spectrometry related techniques in analysis of commonly used forms of traditional Chinese medicine formulas in the last 3 years. Stringent quality control is of great significance for the modernization and globalization of traditional Chinese medicine, and this bibliometric analysis provided the first and comprehensive summary within this field.

  3. Study on the Disease Prevention of Silver Carps Bighead by Chinese Herbal Medicine%中草药对鲢鳙鱼病害防治研究

    Institute of Scientific and Technical Information of China (English)

    杨军; 刘远高; 邹四新; 何志刚; 袁祖菊

    2013-01-01

    通过人工感染鲢鳙鱼试验研究了五倍子、大黄、地锦草、苦楝、白头翁、乌桕、辣蓼及铁苋菜对鲢鳙鱼常见病害的治疗效果.结果表明,中草药对于其常见病害具有一定的防治作用,为鲢鳙鱼病害防治提供了参考.%Effect of gallnut,rhubarb,humifuse euphorbia herb,neem,Chinese pulsatilla root,Chinese tallow tree,red-knees herb and copperleaf therapeutic on silver carps bighead common diseases were studied by artificial infection test.The results showed that Chinese herbal medicine for the common disease had a certain control effect,which provided some references for disease prevention and treatment of silver carps bighead.

  4. Chinese Herbal Medicine as an Adjunctive Therapy for Breast Cancer: A Systematic Review and Meta-Analysis

    Directory of Open Access Journals (Sweden)

    Libing Zhu

    2016-01-01

    Full Text Available Chinese herbal medicine (CHM has been widely used as an adjunctive therapy for breast cancer, while its efficacy remains unexplored. The purpose of this study is to evaluate the efficacy of CHM combined with chemotherapy for breast cancer. The study results showed that CHM combined with chemotherapy significantly increased tumor response and KPS as compared to using chemotherapy alone (RR = 1.36; 95% CI = 1.24–1.48; P<0.00001; RR = 1.38; 95% CI = 1.26–1.52; P<0.00001, resp.. Besides, CHM as an adjunctive therapy significantly reduced the nausea and vomiting at toxicity grade of III–IV (RR = 0.37; 95% CI = 0.27–0.52; P<0.00001. Moreover, the combined therapy significantly prevented the decline of WBC in patients under chemotherapy at toxicity grade of III–IV (RR = 0.49; 95% CI = 0.34–0.69; P<0.00001 and prevented the decline of platelet at toxicity grade of III–IV or I–IV (RR = 0.29; 95% CI = 0.12–0.73; P=0.008; RR = 0.77; 95% CI = 0.63–0.94; P=0.009, resp.. This study suggests that CHM combined with chemotherapy in comparison with chemotherapy alone can significantly enhance tumor response, improve KPS, and alleviate toxicity induced by chemotherapy in breast cancer patients. However, a firm conclusion could not be reached due to the lack of high quality trials and large-scale RCTs, so further trials with higher quality and larger scale are needed.

  5. Screening of anti-halitosis Chinese herbal compounds%抗口臭中药复方的筛选

    Institute of Scientific and Technical Information of China (English)

    李金陆; 杨圣辉; 连增林

    2012-01-01

    Objective To screen out effective and safe anti-halitosis traditional Chinese herbs (TCBs) , in order to develop anti-halitosis products for oral care. Method The Hallimeter was used to detect the metabolic gases containing sulfides produced by halitosis relative bacteria pre- or post-loading with 9 TCBs. The screening was performed in two steps in which single and compound herbs were tested successively to identify the effective herbal prescriptions. Result The effects of smoked plum and clove showed stronger effect on inhibiting metabolic gas production, while chrysanthemum was more effective on inhibiting metabolic production of sulfide even at a level below effective concentration. Conclusion Smoked plum, Clove and Chrysanthemum can effectively inhibit halitosis relative bacteria metabolism. The anti-halitosis effect of these herbs need be further confirmed in clinical study.%目的 筛选有效、安全的抗口臭中药处方,为抗口臭护理用品提供研发实验依据.方法 选用9味可食性中药用口臭主要相关菌种的敏感试验及硫化物检测仪( Hallimeter)检测含硫代谢产物.按单味中药及复合配方两步筛选,确定有效处方.结果 9味中药敏感试验证实乌梅、丁香抑菌作用强于其它中药,菊花降低硫化物较强,特别在无抑菌浓度作用下仍有减低硫化物作用.结论 乌梅、丁香、菊花配方有较强抗口臭作用,待进一步临床证实.

  6. Increase of insulin sensitivity in diabetic rats received Die-Huang-Wan, a herbal mixture used in Chinese traditional medicine

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    WU Yang-Chang; HSU Jen-Hao; LIU I-Min; LIOU Shorong-Shii; SU Hui-Chen; CHENG Juei-Tang

    2002-01-01

    AIM: Effects on insulin sensitivity of Die-Huang-Wan, the herbal mixture widely used to treat diabetic disorder in Chinese traditional medicine, were investigated in vivo. METHODS: The obese Zucker rats were employed as insulin-resistant animal model. Also, insulin-resistance was induced by the repeated intraperitoneal injections of long-acting human insulin at 0.5 U/kg three times daily into adult male Wistar rats. Insulin resistance was identified using the loss of tolbutamide (10 mg/kg) or electroacupuncture (EA)-induced plasma glucose lowering action. The plasma glucose concentration was examined by glucose oxidase assay. RESULTS: The plasma glucose-lowering action induced by tolbutamide was significantly enhanced in obese Zucker rats receiving the repeated administration of Die-Huang-Wan at dosage of 26 mg/kg for 3 d. Furthermore, administration of Die-Huang-Wan delayed the formation of insulin resistance in rats that were induced by the daily repeated injection of human long-acting insulin at 0.5 U/kg three times daily and identified by the loss of tolbutamide- or EA-induced hypoglycemia. In streptozotocininduced diabetic rats, oral administration of metformin at 320 mg/kg once daily made an increase of the response to exogenous short-acting human insulin 15 d later. This is consistent with the view that metformin can increase insulin sensitivity. Similar treatment with Die-Huang-Wan at an effective dose (26.0 mg/kg) also increased the plasma glucose lowering action of exogenous insulin at 10 d later. The effect of Die-Huang-Wan on insulin sensitivity seems to produce more rapidly than that of metformin. CONCLUSION: The present study found that oral administration of Die-Huang-Wan increased insulin sensitivity and delayed the development of insulin resistance in rats.

  7. The Therapeutic Effects of the Chinese Herbal Medicine, Lang Chuang Fang Granule, on Lupus-Prone MRL/lpr Mice

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    Kai-Peng Huang

    2016-01-01

    Full Text Available Systemic lupus erythematosus (SLE is a chronic autoimmune disease that leads to severe multiorgan damage. Lang Chuang Fang (LCF is a Chinese herbal medicine that is clinically prescribed for treating SLE. In this study, we examined the therapeutic effects of LCF granule on lupus-prone MRL/lpr mice. Female mice were randomly separated into six groups, and LCF treatment groups received LCF granule at the dosage of 0.97 g/kg/d, 1.95 g/kg/d, and 3.90 g/kg/d, respectively. Here, we found that, compared to the MRL/lpr mice, both the spleen coefficient and thymus coefficient were reduced in the LCF granule-treated mice. There was a marked downregulation in CRP and anti-dsDNA autoantibody and an evident upregulation of CH50 in LCF granule-treated mice. LCF granule treatment also obviously reduced the proteinuria, BUN, and SCr levels in MRL/lpr mice at the dosage of 0.97 g/kg/d, 1.95 g/kg/d, and 3.90 g/kg/d, indicating that LCF granule alleviated the renal injury of MRL/lpr mice. Furthermore, LCF granule decreased p65 NF-κB levels and increased Sirt1 and Nrf2 levels in the kidney tissues of MRL/lpr mice, which might elucidate the beneficial effects of LCF on lupus nephritis. In conclusion, this study demonstrates that LCF granule has therapeutic effects on lupus-prone MRL/lpr mice.

  8. A Hexa-Herbal TCM Decoction Used to Treat Skin Inflammation: An LC-MS-Based Phytochemical Analysis.

    Science.gov (United States)

    Chang, Jennifer B; Lane, Majella E; Yang, Min; Heinrich, Michael

    2016-07-01

    In order to understand the chemical relationship between a traditional hexa-herbal Chinese medicine formula and botanical drugs it is derived from, an analytical platform comprising liquid chromatography coupled with triple quadrupole mass spectrometry and data mining was developed to separate and identify key chemical components. The hexa-herbal formula comprises the rootstock of Scutellaria baicalensis, Rheum tanguticum, Sophora flavescens, the root bark of Dictamnus dasycarpus, the bark of Phellodendron chinense, and the fruit of Kochia scoparia. Seventy-three compounds including alkaloids, anthraquinone derivatives, coumarins, coumarins derivatives, flavonoids, flavone glycosides, naphthalene derivatives, phenylbutanone glucopyranoside, phenolic acids, pterocarpans, stilbenes, stilbenes derivatives, and tannins were putatively identified based on mass measurement and characteristic fragment ions. Among the botanical drugs of the hexa-herbal Chinese medicine formula, the rootstock of R. tanguticum and S. flavescens, bark of P. chinense, and rootstock of S. baicalensis contributed to the majority of the extracted metabolites of the formula decoction. The developed method appeared to be a versatile tool for monitoring chemical constituents in extracts of a traditional Chinese medicine formula in a relatively comprehensive and systematic manner, and helped to understand the importance of the individual botanical drugs within a formulation.

  9. Effect of Nourishing “Yin”-Removing “Fire” Chinese Herbal Mixture on Hypothalamic NKB/NK3R Expression in Female Precocious Rats

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    Shiran Wang

    2014-01-01

    Full Text Available Aim. The present study aims to investigate the effects of nourishing “Yin”-removing “Fire” Chinese herb mixture on the hypothalamic NKB/NK3R expression in female precocious model rats. Materials and Methods. Female Sprague-Dawley rats were randomly divided into four groups: normal (N, central precocious puberty (CPP model (M, CPP fed with Chinese herbal mixture (CHM, and CPP fed with normal saline (MS. Rats on postnatal day 5 were given a single subcutaneous injection of 300 μg to establish CPP model rats. Rats of CHM and MS groups were continuously administered with nourishing “Yin”-removing “Fire” Chinese herb mixture or saline since postnatal day 15. The expressions of hypothalamic NKB/NK3R were detected by means of real-time PCR, western blot, and immunofluorescence histochemistry. Results. The day of vaginal opening and establishment of two regular estrous cycles were delayed in the CHM group compared with M and MS groups. The expression of hypothalamic NKB/NK3R mRNA and protein in the arcuate nucleus (ARC and medial preoptic (MPO area were decreased significantly in the CHM group compared with the M and MS groups on the day of onset-puberty. Conclusions. These results indicate that the NKB/NK3R signaling pathway might be involved in the effect of herbal mixture treatment on CPP.

  10. Study on Treatment of Polycystic Ovarian Syndrome with Infertility by Combined Therapy of Chinese Herbal Medicine and Compound Cyproterone Acetate

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    TAO Li-li (陶莉莉); CHEN Xiao-ping (陈小平); GU Zheng-tian (顾正田)

    2003-01-01

    Objective: To evaluate the effect of combined therapy of Chinese herbal medicine and compound cyproterone acetate (CPA) in treating non-obesity polycystic ovarian syndrome (PCOS) and to explore its mechanism in improving withdrawal ovulation. Methods:Eighty-six patients of non-obesity PCOS, typed as Shen-deficiency with blood stasis Syndrome or Shen-deficiency with Phlegm-Dampness Syndrome by Syndrome Differentiation in traditional Chines medicine, were randomly divided into three groups: (1) The TCM group (n=26) was treated with Chinese drugs for 6 menstrual cycles; (2) The western medicine (WM) group (n=30) was treated with 1 tablet of CPA for 21 days, with the treatment beginning from the 5th day of menstruation. The treatment was given for 3 menstrual cycles by repetitious medication, which stopped and restarted on the 5th day of withdrawal bleeding. Then the ovulation promoting therapy was applied by using clomifene citrate and human chorionic gonadotropin (CC/Hcg) for 3 menstrual cycles; (3) The TCM-WM group (n=30) was treated with the medications used for the above two groups. The menstrual cycle, the volume and duration of the menstruation, as well as the improvement of acne and pilosis [Ferriman-Gallway (F-G) scoring]were observed after 3 cycles ended. Moreover, condition of ovulation was monitored by B-ultrasonography at the 4th-6th cycle and status of pregnancy was observed. Results: Compared with before treatment, the blood level of luteinizing hormone (LH) and testosterone (T) in all 3 groups after treatment significantly decreased (P<0.05), with its ratio to follicle-stimulating hormone (LH/FSH) recovered to normal, but without markedly change in levels of FSH, estradiol (E2) and prolactin (PRL). The menstrual cycle in most patients got regular and acne significantly alleviated (P<0.05), and the improvement of infrequent menstruation and acne was better in the WM group and the TCM-WM group than that in the TCM group, but pilosis showed no significant

  11. 中药中速灭威残留量的酶联免疫检测方法%Metolcarb Residue Analysis Using ELISA in Chinese Herbal Medicines

    Institute of Scientific and Technical Information of China (English)

    张曙光; 王俊平; 生威; 张燕; 王硕

    2012-01-01

    A direct competitive ELISA was established in detecting Metolcarb residues in Chinese herbal medicines, such as Lonicera chrysantha.Lycium chinense, Radix Ginseng, Radix Isatidis, Folium lsatidis and Yuanhu painkillers. After Lo-nicera chrysantha and so on were mashed and homogenized, methanolextraction, rotary steaming, and PBS were used to make up to volume. Moderate dilution then could eliminate the influence of matrix, which was detected by ELISA. In Chinese herbal medicines.the recovery rate was 66%-91%,with variation coefficient less than 30%. The method is simple, quick, sensitive and accurate in detecting the Metolcarb residues in Chinese herbal medicines.%建立了直接竞争酶联免寝法(ELISA)测定金银花、枸杞、人参、板蓝根、大青叶和圆弧止痛片为代表的中药中速灭威的残留量.金银花等经过粉碎,加入甲醇提取、旋蒸、PBS复溶等简单前处理之后,再经过适度的稀释可以达到消除基质影响,用ELISA进行测定.中药样品添加回收率为64.00% ~ 91.30%.变异系数均小于30.12%.结果表明,该方法可以简单、快速、灵敏、准确地检测出金银花、枸杞、人参、板蓝根、大青叶和圆弧止痛片等中药中速灭威的残留量.

  12. Research on Compound Chinese Herbal Medicine against Newcastle Disease Virus Activity in vitro%复方中药体外抗新城疫病毒活性研究

    Institute of Scientific and Technical Information of China (English)

    赵增成; 林树乾; 傅剑; 黄中利

    2013-01-01

    In order to screen efficient Chinese herbal medicine against Newcastle disease virus, 8 kinds of compound Chinese herbal medicine against Newcastle disease virus were determined by chick embryo test. The result showed that some compound Chinese herbal medicine had better inhibition effect, including jingfang baidu powder, yinqiao powder,baitouweng decoction and shuanghuanlian oral liquid.%为了筛选出高效的抗新城疫病毒中药,采用鸡胚接种试验,对8种经典清热解毒复方中药的抗新城疫病毒效果进行了测定.结果表明,荆防败毒散、银翘散、白头翁汤、双黄连口服液在体外对新城疫病毒具有较好的抑制作用.

  13. Chinese Herbal Medicine and Acupuncture Used for Rehabilitation of the Impaired Urinary System in Patients with Paraplegia -A Report of 52 Cases

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    邹颖; 周文艳

    2005-01-01

    @@ Infection of the urinary system is frequently seen in the paraplegic patients with urinary complications,which is one of the main reasons for the late death in such cases. The effects of the therapeutic method adopted for the urinary rehabilitation are directly related to the life quality and survival time of the paraplegic patients. Since 1999-2002, the authors had applied Chinese herbal medicine combined with acupuncture for the urinary rehabilitation in 52 paraplegic patients, with quite good therapeuticresults as reported in the following.

  14. Preventive Effects of a Chinese Herbal Formula, Shengjiang Xiexin Decoction, on Irinotecan-Induced Delayed-Onset Diarrhea in Rats

    Science.gov (United States)

    Zhang, Pan; Liu, Sida; Pan, Lin

    2017-01-01

    Irinotecan is a well-known chemotherapy drug for the treatment of various cancers. However, delayed-onset diarrhea is a common adverse reaction, limiting the application of the drug. The study presented was designed to evaluate the preventive effects of Shengjiang Xiexin decoction (SXD) on irinotecan-induced diarrhea and to explore the possible mechanisms of this action. We established a diarrhea rat model. The condition of the rats was observed. The proliferation and apoptosis of intestinal cells were measured using immunohistochemical assays and a caspase-3 activity assay, respectively. The expression of Lgr5 and CD44 staining were used to observe intestinal stem cells (ISCs). In addition, the activity of β-glucuronidase in the rats' feces was measured. Our results showed that the number of proliferating intestinal cells in the SXD groups was obviously higher, while the activity of caspase-3 was lower. The expression of Lgr5 and the integrated option density (IOD) of CD44 stain were increased significantly by SXD. Additionally, SXD decreased the activity of β-glucuronidase after irinotecan administration. In conclusion, SXD exhibited preventive effects on irinotecan-induced diarrhea, and this action was associated with an inhibitory effect on intestinal apoptosis and β-glucuronidase and a promotive effect on intestinal cell proliferation due to increased maintenance of ISCs. PMID:28167974

  15. Preventive Effects of a Chinese Herbal Formula, Shengjiang Xiexin Decoction, on Irinotecan-Induced Delayed-Onset Diarrhea in Rats

    Directory of Open Access Journals (Sweden)

    Chao Deng

    2017-01-01

    Full Text Available Irinotecan is a well-known chemotherapy drug for the treatment of various cancers. However, delayed-onset diarrhea is a common adverse reaction, limiting the application of the drug. The study presented was designed to evaluate the preventive effects of Shengjiang Xiexin decoction (SXD on irinotecan-induced diarrhea and to explore the possible mechanisms of this action. We established a diarrhea rat model. The condition of the rats was observed. The proliferation and apoptosis of intestinal cells were measured using immunohistochemical assays and a caspase-3 activity assay, respectively. The expression of Lgr5 and CD44 staining were used to observe intestinal stem cells (ISCs. In addition, the activity of β-glucuronidase in the rats’ feces was measured. Our results showed that the number of proliferating intestinal cells in the SXD groups was obviously higher, while the activity of caspase-3 was lower. The expression of Lgr5 and the integrated option density (IOD of CD44 stain were increased significantly by SXD. Additionally, SXD decreased the activity of β-glucuronidase after irinotecan administration. In conclusion, SXD exhibited preventive effects on irinotecan-induced diarrhea, and this action was associated with an inhibitory effect on intestinal apoptosis and β-glucuronidase and a promotive effect on intestinal cell proliferation due to increased maintenance of ISCs.

  16. Effect of Chinese herbal compound on liver fibrosis in rabbits with schistosomiasis by B-ultrasound

    Institute of Scientific and Technical Information of China (English)

    Xiao-Lu Liang; Jia-Ying Yuan

    2013-01-01

    Objective:To explore the value of B-ultrasound on the evaluation of the effects of traditional Chinese medicine compound of Radix astragali, Salvia miltiorrhiza and Angelica sinensis, and TCM +praziquantel on liver fibrosis in rabbits with schistosomiasis. Methods: The hepatic fibrosis model in rabbits with schistosomiasis was established. The experimental animals (24 rabbits) were randomly divided into four groups (group A, B, C and D, n=6). Group A (control group) was only treated by praziquantel; Group B was treated by mixture of Radix astragali and Salvia miltiorrhiza +praziquantel; Group C was treated by mixture of Radix astragali and Angelica sinensis +praziquantel; Group D was treated by mixture of Radix astragali, Salvia miltiorrhiza and Angelica sinensis +praziquantel. Then B-ultrasonogram was used to evaluate the effects. Results: Each group showed certain curative effect on liver fibrosis in rabbits with schistosomiasis. The efficacy of group B, C and D was better than group A, and that of group D was the best. The differences in long diameter, thickness diameter, transverse diameter and portal vein inner diameter of liver before and after treatment were statistically significant (P<0.05). The liver function indexes and liver fibrosis indexes were significantly improved after treatment (P<0.05). Conclusions:The mixture of Radix astragali, Salvia miltiorrhiza and Angelica sinensis combined with Western medicine treatment can obviously improve the efficacy on liver fibrosis of schistosomiasis.

  17. Improved sexual behavior in male rats treated with a Chinese herbal extract: hormonal and neuronal implications

    Institute of Scientific and Technical Information of China (English)

    Paola Zanoli; Augusta Benelli; Manuela Zavatti; Marianna Rivasi; Claudia Baraldi; Mario Baraldi

    2008-01-01

    Aim: To investigate the influence of an extract obtained from five Chinese medicinal plants on sexual behavior of adult male rats. Methods: The extract was administered at doses of 30, 60 and 120 mg/kg by oral gavage, acutely (one time, 45 rain before mating test) or subchronically (daily for 10 days) in sexually potent and sexually sluggish/impo-tent rats. Sexual behavior, serum levels of luteinizing hormone (LH) and testosterone (T) were evaluated in treated rats and compared with controls receiving vehicle. The effect of the extract on central dopaminergic neurotransmis-sion was assessed in the nucleus accumbens using a microdialysis technique. Results: In sexually potent rats, both acute and subchronic treatment with the extract dosed at 30 and 60 mg/kg reduced mount latency and intromission latency. In sluggish/impotent rats, the acutely administered extract at the dose of 60 mg/kg shortened ejaculation latency, whereas subchronically administered at the doses of 30 and 60 mg/kg, reduced mount, intromission and ejaculation latencies, increasing also the percentage of mounting and ejaculating rats. The extract dosed at 60 mg/kg significantly increased LH and T following acute and subchronic administration and increased 3,4-dihydroxyphenylacetic acid levels in the nucleus accumbens, 30 rain after the acute administration. Conclusion: The improvement in both appetitive and consummatory components of sexual behavior observed in male rats treated with the extract could be scribed to increased serum T level in parallel with the activation of the central dopaminergic system.

  18. The role of Chinese herbal medicines in a rat model of chronic colitis

    Institute of Scientific and Technical Information of China (English)

    Xiao Lan Tian; Marisabel Mourelle; Yu Ling Li; Francisco Guarner; Juan-R Malagelada

    2000-01-01

    AIM To investigate a mixture of traditional Chinese medicine (TCM) in the prevention of chronic colitis inrats.METHODS Sixty rats were divided into 3 groups. Colitis was induced by trinitrobenzene-sulfonic acid(TNB). On day 10, all the survived rats were killed, the mortality and intestinal obstruction rate werecalculated, the colonic lesion score was assessed and collagenase activity and collagen concentration weremeasured.RESULTS The survival rate was much lower and intestinal obstruction rate much higher in TNB than thosein TCM, they were 53% and 81% vs. 80% and 24% (P<0.05 and P<0.01, respectively). There were alsosignificant differences in colonic stricture score and colonic weight between TNB and TCM groups (1.75±1.2 vs 0.22±0.67 and 0.57±0.36 vs 0.31±0.10, P<0.01 and P<0.05, respectively). No hydroxyprolineand collagenase activity differences were found between the two groups.CONCLUSION This mixture of TCM prevents the formation of intestinal stricture, increases the survivalrate and decreases intestinal obstruction rate in a rat model of chronic colitis.

  19. Characterization of the Anti-Influenza Activity of the Chinese Herbal Plant Paeonia lactiflora

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    Jin-Yuan Ho

    2014-04-01

    Full Text Available Bai Shao (BS, the root of Paeonia lactiflora Pall., a common Chinese herb in many recipes used to treat viral infection and liver diseases, is recognized for its ability to nourish menstruation, its Yin convergence, and as an antiperspirant. However, the mechanism and components for its antiviral function remain to be elucidated. In this study, an ethanolic extract of BS was further partitioned into aqueous and organic parts (EAex for in vitro functional study and in vivo efficacy testing. EAex exhibited an IC50 of 0.016 ± 0.005 mg/mL against influenza virus A/WSN/33 (H1N1, with broad-spectrum inhibitory activity against different strains of human influenza A viruses, including clinical oseltamivir-resistant isolates and an H1N1pdm strain. The synthesis of both viral RNA and protein was profoundly inhibited when the cells were treated with EAex. A time-of-addition assay demonstrated that EAex exerted its antiviral activity at various stages of the virus replication cycle. We addressed its antiviral activity at virus entry and demonstrated that EAex inhibits viral hemagglutination and viral binding to and penetration into host cells. In vivo animal testing showed that 200 mg/kg/d of EAex offered significant protection against viral infection. We conclude that BS possesses antiviral activity and has the potential for development as an anti-influenza agent.

  20. Herbal Medicine

    Science.gov (United States)

    ... for its scent, flavor, or therapeutic properties. Herbal medicines are one type of dietary supplement. They are ... and fresh or dried plants. People use herbal medicines to try to maintain or improve their health. ...

  1. Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine

    Institute of Scientific and Technical Information of China (English)

    Rui WANG; Han YAN; Xi-can TANG

    2006-01-01

    Huperzine A (HupA), a novel alkaloid isolated from the Chinese herb Huperzia serrata, is a potent, highly specific and reversible inhibitor of acetylcholinesterase (AChE). Compared with tacrine, donepezil, and rivastigmine, HupA has better penetration through the blood-brain barrier, higher oral bioavailability, and longer duration of AChE inhibitory action. HupA has been found to improve cognitive deficits in a broad range of animal models. HupA possesses the ability to protect cells against hydrogen peroxide, β-amyloid protein (or peptide), glutamate,ischemia and staurosporine-induced cytotoxicity and apoptosis. These protective effects are related to its ability to attenuate oxidative stress, regulate the expression of apoptotic proteins Bcl-2, Bax, P53, and caspase-3, protect mitochondria, upregulate nerve growth factor and its receptors, and interfere with amyloid precursor protein metabolism. Antagonizing effects of HupA on N-methyl-D-aspartate receptors and potassium currents may also contribute to its neuroprotection as well. Pharmacokinetic studies in rodents, canines, and healthy human volunteers indicated that HupA was absorbed rapidly, distributed widely in the body, and eliminated at a moderate rate with the property of slow and prolonged release after oral administration. Animal and clinical safety tests showed that HupA had no unexpected toxicity, particularly the dose-limiting hepatotoxicity induced by tacrine. The phase Ⅳ clinical trials in China have demonstrated that HupA significantly improved memory deficits in elderly people with benign senescent forgetfulness, and patients with Alzheimer disease and vascular dementia, with minimal peripheral cholinergic side effects and no unexpected toxicity. HupA can also be used as a protective agent against organophosphate intoxication.

  2. Oral treatment with the herbal formula B401 protects against aging-dependent neurodegeneration by attenuating oxidative stress and apoptosis in the brain of R6/2 mice

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    Wang SE

    2015-11-01

    Full Text Available Sheue-Er Wang,1,2 Ching-Lung Lin,1 Chih-Hsiang Hsu,1 Shuenn-Jyi Sheu,3 Chung-Hsin Wu1 1Department of Life Science, National Taiwan Normal University, Taipei, 2Department of Pathological Inspection, Saint Paul’s Hospital, Taoyuan, 3Brion Research Institute of Taiwan, Taipei, Taiwan Background: Neurodegeneration is characterized by progressive neurological deficits due to selective neuronal loss in the nervous system. Huntington’s disease (HD is an incurable neurodegenerative disorder. Neurodegeneration in HD patients shows aging-dependent pattern. Our previous study has suggested that a herbal formula B401 may have neuroprotective effects in the brains of R6/2 mice. Objective: To clarify possible mechanisms for neurodegeneration, which improves the understanding the aging process. This study focuses on clarifying neurodegenerative mechanisms and searching potential therapeutic targets in HD patients. Methods: The oxidative stress and apoptosis were compared in the brain tissue between R6/2 HD mice with and without oral B401 treatment. Expressions of proteins for oxidative stress and apoptosis in the brain tissue of R6/2 HD mice were examined by using immunostaining and Western blotting techniques. Results: R6/2 HD mice with oral B401 treatment significantly reduced reactive oxygen species levels in the blood, but markedly increased expressions of superoxide dismutase 2 in the brain tissue. Furthermore, R6/2 HD mice with oral B401 treatment significantly increased expressions of B-cell lymphoma 2 (Bcl-2, but significantly reduced expressions of Bcl-2-associated X protein (Bax, calpain, and caspase-3 in the brain tissue. Conclusion: Our findings provide evidence that the herbal formula B401 can remedy for aging-dependent neurodegeneration of R6/2 mice via suppressing oxidative stress and apoptosis in the brain. We suggest that the herbal formula B401 can be developed as a potential health supplement for ameliorating aging

  3. Local use of iontophoresis with traditional Chinese herbal medicine, e.g., Gu-Sui-Bu (Rhizoma Drynariae may accelerate orthodontic tooth movement

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    Yongming Li

    2013-01-01

    Full Text Available Introduction: Mechanical force is not the only means to cause tooth movement, but just one kind of stimuli for it. Biological stimuli, with potential of accelerating alveolar bone remodeling, other than mechanical force, have been attracted by orthodontists who are combating prolonged treatment duration. It has been approved that some traditional Chinese medicines, such as Gu-Sui-Bu (Rhizoma Drynaria, affect the process of bone remodeling. The Hypothesis: We make the hypothesis that local use of iontophoresis with Gu-Sui-Bu (Rhizoma Drynaria as a non-invasive and safe drug delivery system with no trauma, risk of infection or damage to patients is a new potential approach for accelerating orthodontic tooth movement, and shorten the orthodontic treatment time. Evaluation of the Hypothesis: Gu-Sui-Bu is effective at inducing bone remodeling, and iontophoresis as a non-invasive technique for drug delivery, is suitable for the transmission of some traditional Chinese herbal medicines into periodontal tissues.

  4. Chinese Herbal Medicine Analysis of External Treatment for Cancer Pain%外治癌痛中药的药性分析

    Institute of Scientific and Technical Information of China (English)

    董昌盛; 王菊勇; 许玲; 张瑞新; 劳力行

    2012-01-01

    Objective; Analysis the Chinese herbal nature of common external treatment herbals, investigate the trend of medication. Method; Retrieval the clinical research of treating cancer pain with Traditional Chinese Herbs which published on domestic periodicals from 1/1980 to 12/2011 , Statistics the frequency and ratio of drugs and its nature. Result; The principal activating blood and resolving stasis drug and detoxification and analgesia herbal drug are the main external treatment herbs, the TCM generally with warm property, the TCM common tastes acrid, common Channel distributions of Traditional Chinese Herbs is liver meridian, most of Traditional Chinese Herbs is non-toxic. Conclusion; The external treatment of cancer pain should be considered activating blood and resolving stasis and detoxification and analgesia, pay attention to pungent and fragrant of acrid herbs, the treatment of cancer pain may choose liver meridian herbs, we should pay attention to the toxicity of Traditional Chinese Herbs for medication safety.%分析中医外治癌痛常用中药的药性,探讨用药趋势.检索1980年1月~2011年12月年在国内医学期刊公开发表的中医外治法治疗癌性疼痛的临床研究文献,统计分析常用中药和药性的频次和频率.结果表明:中药外治癌痛的药物主要为活血化瘀和解毒止痛药,药性多温,味多辛,主要归肝经,大多无毒.癌痛外治应考虑行气活血化瘀、解毒止痛的治疗方法,注意辛味药辛香走窜的药理作用,要酌情选用归肝经的药物,并注意中药毒性,确保用药安全.

  5. Clinical Observation on the Combined Treatment of 57 Cases of Non-small Cell Lung Cancer Using Argon-Helium Cryosurgery and Chinese Herbal Medicine

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Objective: To observe the clinical effect of the combined therapy using argon-helium cryosurgery (Ar-He knife) and Chinese herbal medicine in treating non-small cell lung cancer (NSCLC).Methods: Fifty-seven patients of NSCLC were treated with the combined therapy and observed. Results:The treatment was successfully completed in all patients with mild adverse reactions. The effective rate was 83.8% 3 months after the operation, 79.6% 6 months after the operation, and 77.3% 12 months after the operation, with median survival of 9 months. The survival rate after 12 months was 46.67%(21/45), 34.62% (9/26) after 18 months, and 36.36% (4/11) after 24 months. Conclusion: Argon-helium cryosurgery therapy is superior in its assured orientation, quick tumor load deprivation and less postoperational reaction. Combined with Chinese herbal medication, Argon-helium cryosurgery therapy can prolong survival time, relieve clinical symptoms, and elevate the quality of life in NSCLC patients, and is thus worthy of promotion.

  6. [Regulative mechanisms of mammalian target of rapamycin signaling pathway in glomerular hypertrophy in diabetic nephropathy and interventional effects of Chinese herbal medicine].

    Science.gov (United States)

    Yang, Jing-Jing; Huang, Yan-ru; Wan, Yi-gang; Shen, Shan-mei; Mao, Zhi-min; Wu, Wei; Yao, Jian

    2015-08-01

    Glomerular hypertrophy is the main pathological characteristic in the early stage of diabetic nephropathy (DN), and its regulatory mechanism is closely related to mammalian target of rapamycin (mTOR) signaling pathway activity. mTOR includes mTOR complex 1 (mTORC1) and mTOR complex 2(mTORC2), in which, the upstream pathway of mTORC1 is phosphatidylinositol-3-kinase (PI3K)/serine-threonine kinase(Akt)/adenosine monophosphate activated protein kinase(AMPK), and the representative signaling molecules in the downstream pathway of mTORC1 are 4E-binding proteins(4EBP) and phosphoprotein 70 S6Kinase(p70S6K). Some Chinese herbal extracts could improve cell proliferation via intervening the expressions of the key molecules in the upstream or downstream of PIK/Akt/mTOR signaling pathway in vivo. As for glomerular mesangial cells(MC) and podocyte, mTOR plays an important role in regulating glomerular inherent cells, including adjusting cell cycle, energy metabolism and matrix protein synthesis. Rapamycin, the inhibitor of mTOR, could suppress glomerular inherent cell hypertrophy, cell proliferation, glomerular basement membrane (GBM) thickening and mesangial matrix deposition in model rats with DN. Some Chinese herbal extracts could alleviate glomerular lesions by intervening mTOR signaling pathway activity in renal tissue of DN animal models or in renal inherent cells in vivo and in vitro.

  7. A Comparative Study of Selected Trace Element Content in Malay and Chinese Traditional Herbal Medicine (THM Using an Inductively Coupled Plasma-Mass Spectrometer (ICP-MS

    Directory of Open Access Journals (Sweden)

    Sharifah Mohamad

    2013-02-01

    Full Text Available A total of 60 products of traditional herbal medicine (THM in various dosage forms of herbal preparation were analyzed to determine selected trace elements (i.e., Zn, Mn, Cu, Cd, and Se using ICP-MS. Thirty types of both Chinese and Malay THMs were chosen to represent each population. The closed vessel acid microwave digestion method, using CEM MARS 5, was employed for the extraction of the selected trace elements. The digestion method applied was validated by using certified reference material from the Trace Element in Spinach Leaves (SRM1570a. The recoveries of all elements were found to be in the range of 85.3%–98.9%. The results indicated that Zn, Mn, Cu, Cd and Se have their own trends of concentrations in all samples studied. The daily intake concentrations of the elements were in the following order: Mn > Zn > Cu > Se > Cd. Concentrations of all five elements were found to be dominant in Chinese THMs. The essentiality of the selected trace elements was also assessed, based on the recommended daily allowance (RDA, adequate intake (AI and the United States Pharmacopeia (USP for trace elements as reference. The concentrations of all elements studied were below the RDA, AI and USP values, which fall within the essential concentration range, except for cadmium.

  8. 中草药对牙鲆免疫力的影响%Effect of Chinese herbal medicine on immunity of flounder Paralich thvs olivaceus

    Institute of Scientific and Technical Information of China (English)

    李霞; 马驰原; 李雅娟; 姜志强; 王斌; 姚远; 孔相铁

    2011-01-01

    vFlounder (Paralichthys olivaceus)juveniles, (22.89± 12.60)g, were stocked in circulating water and temperature controlled channels and fed the diets containing 1%, 3% and 5% Chinese herbal medicine. On the 15th, 30th and 45th day, serological immunological index were analyzed. Histology section of epithelium and the number of mucus cells were observed under microscope. Noxious experiment with injecting Edwardsiella Tarda into the back muscle was carried. Results showed that the number of white blood cells, the active of lysozyme, alkaline phosphatasein and the total protein in serum were increased as the inrising of concentration of Chinese herbal medicine and the sustained time under the condition of 3% and 5%. Complement C3 and superoxide dismutase were increased after feeding the diets containing 5% Chinese herbal medicine. Numbers of mucus cells in the skin, the index of spleen and rate of the immune protection were positive correlated with the concentration of Chinese herbal medicine and sustained time. The rate of immune protection was as high as 80% in 5% concentration group. It showed that feeding Chinese herbal medicine added in could improve the flounder's immunity.%以初始体重为(22.89±12.60)g的牙鲆幼鱼为试验对象,在室内控温循环水槽中进行中草药对牙鲆免疫力影响的试验.向基础饲料中添加的中草药含量分别为1%、3%和5%,经过15、30和45 d后分别取血清进行免疫指标的分析测定,取鱼表皮进行常规组织学制片,在光学显微镜下观察粘液细胞的数量变化.饲喂实验结束时通过背部肌肉注射爱得华氏菌进行攻毒实验.结果表明,以3%和5%浓度中草药的牙鲆混合饲料饲喂45 d后牙鲆血液中白细胞数、碱性磷酸酶活性、溶菌酶活性和血清总蛋白含量随中草药添加浓度和投喂时间的增加而增多;而在添加量5%的条件下,补体C3的含量和超氧化物歧化酶活性较对照组有明显增加.牙

  9. Herbal Medicines for Acute Kidney Injury:Evidence, Gaps and Frontiers

    Institute of Scientific and Technical Information of China (English)

    Vale´ rian Bunel; Fan Qu; Pierre Duez; Qi-he Xu

    2015-01-01

    Acute kidney injury (AKI) is a major health threat worldwide. The literature on herbal intervention in AKI was searched from English and Chinese databases and reports were critically analyzed in terms of preventing AKI, promoting repair and regeneration, enhancing extrarenal clearance of uremic toxins, and preventing progression to chronic kidney disease (CKD). Altogether, 16 herbal formulae and a few extracts derived from individual herbs were reported to prevent or mitigate AKI in animal models induced by renal ischemia/reperfusion, cisplastin, gentamicin, glycerol, adenine, sepsis or physical exhaustion. Four formulae and six individual herbs were reported to accelerate recovery and/or to prevent CKD in established AKI animal models. Intrarectal herbal medicines, with or without simultaneous oral administration, were reported in six clinical trials and in an animal model to increase extrarenal clearance of uremic toxins. Additional 13 clinical trials reported oral or intravenous herbal interventions in AKI of different etiologies. Despite recurring problems, notably poor compliance with good practice guidelines for clinical trials and for authentication, naming and quality control of herbal materials, accumulating experimental data on the preventive effects of herbal medicines in AKI look encouraging and urge for better, definitive trials to guide clinical practice. Herbal enemas promoting extrarenal clearance of uremic toxins seem cost-effective, but better clinical evidence is certainly needed before any affirmative recommendation be made for AKI patients without access to dialysis. New frontiers, however, lie in those herbal remedies that promote repair/regeneration and prevent chronicity after AKI. Recent experimental data suggest that this may be possible.

  10. The journey,gain,and thought from engaging in the research of Chinese herbal medicines in China,Japan,and United States%The journey, gain, and thought from engaging in the research of Chinese herbal medicines in China, Japan, and United States

    Institute of Scientific and Technical Information of China (English)

    LIUYan-ze; DENG Zhu-ping

    2011-01-01

    Since early 80s of last century,Chinese herbal medicines focused on the isolation and structural identification of active/chemical compounds have being investigated,started the journey from Henan College of Traditional Chinese Medicine.After one year (1985~ 1986) advanced study in Prof.Jingxi Xie's laboratory in the Institute of Materia Medica,Chinese Academy of Medical Sciences in Beijing,further studies in Prof.Takuo Okuda's laboratory,Okayama University,Japan as a guest researcher from 1988 to 1992 opened a fresh and amazing gate of tannin chemistry.Near 10 years'investigation of tannins and related polyphenols from Chinese herbal medicines,supported by National Natural Science Foundation of China and other grants,some typical herbs containing tannins and related polyphenols as major active components have been in-depth studied,such as Loropetalum chinense,Epilobium angustifolium,Rhodmyrtus tomentosa,Lythrum salicaria,Epilobium pyrricholophum,Rodgersia podoph ylla,Punica granatum,Euphorbia humifusa,and Cornus of ficinalis etc.Hundreds of diversified tannins and related polyphenols have been isolated including monomer,dimmer,trimer of ellagitannins and C-glycosidic tannins etc.

  11. The Rationality of the Hypolipidemic Effect of Alismatis Rhizoma Decoction, a Classical Chinese Medicine Formula in High-Fat Diet-Induced Hyperlipidemic Mice

    OpenAIRE

    Song, Chengwu; Huang, Xiaofei; Lu, Kungang; Peng, Min; Yu, Shanggong; Fang, Nianbai

    2014-01-01

    Alismatis Rhizoma Decoction (ARD) is a classical Traditional Chinese Medicine (TCM) formula for treatment of vertigo with its long history of successful clinical effect. Since vertigo is a symptom of hyperlipidemia, this study aimed at evaluating the hypolipidemic effect of ARD in hyperlipidemic mice induced by high fat diet (HFD) and investigated the rationality of formula combination of Alismatis Rhizoma (AR) and Atractylodis Macrocephalae Rhizoma (AMR). Compared with control group, hyperli...

  12. Anti-colorectal cancer effects of traditional Chinese herbal medicine: Research progress%中药抗结直肠癌作用的研究进展

    Institute of Scientific and Technical Information of China (English)

    周喜汉; 黄赞松; 向发良

    2013-01-01

    Colorectal cancer is a common malignant tumor of the digestive system,and its incidence has an upward trend in China.In recent years,the role of traditional Chinese herbal medicine in treatment of colorectal cancer has attracted the attention of researchers.Traditional Chinese medicine exerts anti-colorectal cancer effects by inhibiting tumor cell proliferation and migration,inducing cell apoptosis and autophagy,reducing telomerase activity and vascular endothelial growth factor production,and arresting cell cycle progression.This paper summarizes the progress in research of anti-colorectal cancer effects of traditional Chinese herbal medicine in terms of mechanisms of action and clinical applications.%大肠癌是常见的消化系恶性肿瘤之一,其发病率在我国呈逐年上升趋势.近年来,中药治疗大肠癌已受到研究者的关注.研究发现,中药具有抗结肠癌的作用,主要通过抑制肿瘤细胞增殖、促进细胞凋亡、抑制端粒酶活性、阻滞细胞周期进展、抑制结肠癌血管内皮生长因子形成、诱导结肠癌细胞自噬、抑制结肠癌细胞迁移等多种途径.本文就中药抗大肠癌的作用机制、实验研究及临床应用进行综述.

  13. 21种中草药提取物对MRSA的抗菌作用研究%Antibacterial Effects of 21 Extracts of Chinese Herbal Medicine on MRSA

    Institute of Scientific and Technical Information of China (English)

    傅若秋; 余琼; 孟德胜; 卢来春; 张雪梅

    2011-01-01

    目的:研究21种中草药提取物对11株耐甲氧西林金黄色葡萄球菌(MRSA)的体外抗茵作用.方法:采用96孔板培养法和涂片法测定各提取物对MRSA的抑茵率及杀菌率.结果:仙鹤草、半枝莲、夏枯草等8种中草药对MRSA具有较强的抗菌活性,其中仙鹤草醇提物、半枝莲水提物抑茵活性最强,浓度为6.25 mg·mL-1时抑茵率均达100%;仙鹤草水提物的杀茵活性最强,浓度为25 mg·mL-1时杀菌率迭100%.结论:仙鹤草、半枝莲提取物具有明显的抗MRSA作用.%OBJECTIVE: To study the antibacterial effects of 21 extracts of Chinese herbal medicine on MRS A in vitro. METHODS: The antibacterial ratio and bactericidal rate of each extract of Chinese herbal medicine were determined by 96-well multiwell plates and direct smear method. RESULTS: 8 Chinese herbal medicines had antibacterial activities on MRSA, such as Agrimoniapi-losa, Scutellaria barbata and Prunella vulgaris. The ethanol extracts of A. Pilosa and water extracts of S. Barbata had the strongest antibacterial activity, and the antibacterial ratio of them reached 100% as the concentrations of them were 6.25 mg·mL'-1 The bactericidal rate of water extracts of A. Pilosa was the highest, reaching 100% as the concentration of it was 25 mg·mL'-1 CONCLUSION: The extracts of A. Pilosa and S. Barbata show clear antibacterial effects on MRSA.

  14. 复方黄芩喷雾剂的抗真菌临床试验%The clinical experiments about Chinese herbal compound Huangqin spray in treatment the disease of the fungal skin

    Institute of Scientific and Technical Information of China (English)

    陈鹏英; 金德珍; 戴蜀平

    2011-01-01

    目的:临床试验观察复方黄芩喷雾剂对皮肤浅层真菌病治疗情况.方法:以益康唑的疗效进行对照,观察外用皮肤浅层真菌感染部位,考察复方黄芩喷雾剂的疗效.结果:复方黄芩喷雾剂对皮肤浅层真菌病疗效显著,其与益康唑在治疗皮肤浅层真菌病无显著性差异,无明显不良反应.结论:复方黄芩喷雾剂可作为治疗皮肤浅层真菌病的复方中药外用制剂,值得推广.%OBJECTIVE To research the clinical experiments about Chinese herbal compound Huangqin spray in treatment disease of the fungal skin. METHODS Apply the medicine on the area of the fungal skin. The detective medicine was Chinese herbal compound Huangqin spray. The reference medicine was Econazole lotion. RESULTS The curative effect of Chinese herbal compound Huangqin spray in treatment the disease of the fungal skin was well and obvious. Its curative effect was well and obvious as Econazole lotion. CONCLUSION The medicine of Chinese herbal compound Huangqin spray is for external use. The Chinese herbal compound can be used in treatment the disease of the fungal skin.

  15. Effects of Chinese Herbal Medicines on Growth Performance and Meat Quality of White Feather Broiler%中草药对白羽肉鸡生产性能及肉品质的影响

    Institute of Scientific and Technical Information of China (English)

    孔娜

    2015-01-01

    A total of 300 white feather broilers were divided into 6 groups (0. 5% Chinese herbal medi-cines additives group,0. 75% Chinese herbal medicines additives group,1. 0% Chinese herbal medicines additives group,1. 25% Chinese herbal medicines additives group,1. 5% Chinese herbal medicines addi-tives group and control group) . The results showed that groupⅢhad the lowest feed/weight ratio and ab-dominal fat rate,while the highest slaughter percentage,whole net carcass percentage,leg muscle percent-age,breast muscle percentage,inosinic acid content and glutamic acid content,for group Ⅲ,feed/weight ratio in 1—3 weeks was 6. 38%(P 0. 05),5. 71%(P 0 . 05 ) ,4 . 35%( P0. 05),3. 09%(P0. 05), 1 . 31%( P0 . 05 ) ,1 . 60%( P0 . 05 ) ,1 . 98%( P0 . 05 ) ,3 . 05%( P0. 05),3. 09%(P0 . 05 ) ,10 . 09%( P0 . 05 ) ,7 . 93%( P0.05)、5.71%(P0.05)、4.35%(P0.05)、1.31%(P 0.05)、1.60%(P0.05)、1.98%(P0.05)、3.05%(P0.05)、3.09%(P0.05)、10.09%(P0.05)、7.93%(P<0.05)、18.76%(P<0.01)。综上,中草药饲料添加剂能提高白羽肉鸡生产性能、屠宰性能及肉品质,最佳剂量为1.0%。

  16. In vivo effects of Chinese herbal recipe, Danshaohuaxian, on apoptosis and proliferation of hepatic stellate cells in hepatic fibrotic rats

    Institute of Scientific and Technical Information of China (English)

    Xiao-Xia Geng; Qin Yang; Ru-Jia Xie; Xin-Hua Luo; Bing Han; Li Ma; Cheng-Xiu Li; Ming-Liang Cheng

    2005-01-01

    AIM: To investigate the effects of Danshaohuaxian (DSHX),a Chinese herbal recipe, on the apoptosis and cell cycles of hepatic stellate cells (HSCs) in rat hepatic fibrosis and its possible mechanisms. METHODS: Seventy-six male Wistar rats were randomly divided into normal control group, hepatic fibrosis group,non-DSHX-treated group and DSHX-treated group. Except for the normal control group, rat hepatic fibrotic models were induced by subcutaneous injection of carbon tetrachloride (CCl4), drinking alcohol, giving diet of hyperlipid and hypoprotein for 8 wk. When the hepatic fibrotic models were produced, 12 rats of hepatic fibrosis group (15 rats survived, others died during the 8 wk) were sacrificed to collect blood and livers. HSCs were isolated from the other 3 rats to detect the apoptotic index (AI) and cell cycles by flow cytometry. DSHX was then given to the DSHX-treated group (1.0 g/kg, PO daily) for 8 wk. At the same time, normal control group and non-DSHX-treated group were given normal saline for 8 wk. At end of the experiment, some rats in these three groups were sacrificed to collect blood and livers, the other rats were used for HSC isolation to detect the apoptotic index (AI) and cell cycles. Then the liver index, serum hyaluronic acid (HA) and alanine aminotransferase (ALT),degree of hepatic fibrosis, urinary excretion of hydroxyproline (Hyp) and expression of collagen types Ⅰ and Ⅲ (COL Ⅰ and Ⅲ) in these four groups were detected respectively.RESULTS: Compared with the indexes of the hepatic fibrosis group and non-DSHX-treated group, the DSHX-treated group revealed a liver index of (0.0267±0.0017 vs 0.0423±0.0044, 0.0295±0.0019, P<0.05), levels of serum HA (200.78±31.71 vs316.17±78.48, 300.86±72.73, P<0.05)and ALT(93.13±5.79 vs 174.5±6.02, 104.75±6.54, P<0.01),and stage of hepatic fibrosis (1.30 vs 4.25, 2.60, P<0.01)all reduced. The urinary excretion of Hyp increased (541.09±73.39 vs 62.00±6.40, 182.44±30.83, P<0

  17. A Chinese 2-herb formula (NF3) promotes hindlimb ischemia-induced neovascularization and wound healing of diabetic rats.

    Science.gov (United States)

    Tam, Jacqueline Chor-Wing; Ko, Chun-Hay; Lau, Kit-Man; To, Ming-Ho; Kwok, Hin-Fai; Chan, Yuet-Wa; Siu, Wing-Sum; Etienne-Selloum, Nelly; Lau, Ching-Po; Chan, Wai-Yee; Leung, Ping-Chung; Fung, Kwok-Pui; Schini-Kerth, Valérie B; Lau, Clara Bik-San

    2014-01-01

    Diabetic foot ulcer is closely associated with peripheral vascular disease. Enhancement of tissue oxidative stress, reduction of nitric oxide (NO) and angiogenic growth factors, and abnormal matrix metalloproteinase (MMP) activity are pathophysiological factors in post-ischemic neovascularization and diabetic wound healing. Our previous study demonstrated that the Chinese 2-herb formula, NF3, showed significant wound healing effects on diabetic foot ulcer rats. A novel rat diabetic foot ulcer with hindlimb ischemia model was established in order to strengthen our claims on the diabetic wound healing and post-ischemic neovascularization effects of NF3. Our results demonstrate that NF3 can significantly reduce the wound area of the diabetic foot ulcer rat with hindlimb ischemia by 21.6% (poxidative stress of ischemic muscles (p<0.001). NF3 significantly stimulated MMP activity involved in angiogenesis. Our study shows, for the first time, the beneficial effects of NF3 in wound healing and post-ischemic neovascularization in diabetes.

  18. Functions of Danggui Buxue Tang, a Chinese Herbal Decoction Containing Astragali Radix and Angelicae Sinensis Radix, in Uterus and Liver are Both Estrogen Receptor-Dependent and -Independent

    Directory of Open Access Journals (Sweden)

    Oliver Zierau

    2014-01-01

    Full Text Available Danggui Buxue Tang (DBT, a herbal decoction containing Astragali Radix (AR and Angelicae Sinensis Radix (ASR, has been used in treating menopausal irregularity in women for more than 800 years in China. Pharmacological results showed that DBT exhibited significant estrogenic properties in vitro, which therefore suggested that DBT could activate the nuclear estrogen receptors. Here, we assessed the estrogenic properties of DBT in an ovariectomized in vivo rat model: DBT was applied to the ovariectomized rats for 3 days. The application of DBT did not alter the weight of uterus and liver, as well as the transcript expression of the proliferation markers including the estrogen receptors α and β. However, DBT stimulated the transcript expression of the estrogen responsive genes. In addition, the inductive role of DBT on the expression of members of the aryl hydrocarbon receptor family in uterus and liver of ovariectomized rats was confirmed. These responses of DBT however were clearly distinct from the response pattern detectable here for 17β-estradiol. Therefore, DBT exhibited weak, but significant, estrogenic properties in vivo; however, some of its activities were independent of the estrogen receptor. Thus, DBT could be an exciting Chinese herbal decoction for an alternative treatment of hormone replacement therapy for women in menopause without subsequent estrogenic side effects.

  19. Interference-free spectrofluorometric quantification of aristolochic acid I and aristololactam I in five Chinese herbal medicines using chemical derivatization enhancement and second-order calibration methods

    Science.gov (United States)

    Hu, Yong; Wu, Hai-Long; Yin, Xiao-Li; Gu, Hui-Wen; Xiao, Rong; Wang, Li; Fang, Huan; Yu, Ru-Qin

    2017-03-01

    A rapid interference-free spectrofluorometric method combined with the excitation-emission matrix fluorescence and the second-order calibration methods based on the alternating penalty trilinear decomposition (APTLD) and the self-weighted alternating trilinear decomposition (SWATLD) algorithms, was proposed for the simultaneous determination of nephrotoxic aristolochic acid I (AA-I) and aristololactam I (AL-I) in five Chinese herbal medicines. The method was based on a chemical derivatization that converts the non-fluorescent AA-I to high-fluorescent AL-I, achieving a high sensitive and simultaneous quantification of the analytes. The variables of the derivatization reaction that conducted by using zinc powder in acetose methanol aqueous solution, were studied and optimized for best quantification results of AA-I and AL-I. The satisfactory results of AA-I and AL-I for the spiked recovery assay were achieved with average recoveries in the range of 100.4-103.8% and RMSEPs green alternative for the quantification of AA-I and AL-I in complex herbal medicine matrices without any prior separations and clear-up processes.

  20. Study on the Effect of Chinese Herbal Medicine in Regulating Peritoneal Lymphatic Stomata and Enhancing Drainage of Ascites in Mice with Liver Fibrosis

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    [1]Ballardini G, Fallani M, Biagini G, et al. Desmin and actin in the identification Ito cells and in monitoring their evolution to myofibroblasts in experimental liver fibrosis. Virchows Achiv B Cell Pathol 1998;56(1):45-49.[2]Runyon BA, Sugano S, Kanel G. A rodent model of cirrhosis, ascites, and bacterial peritonitis. Gastroenterology 1991;100(3):489-493.[3]LI J, LI YH, XUE JC, et al. Protective effect of Tanshinine on experimental damage of hepatocytes. Chinese J of Integrated Traditional and Western Medicine on Liver Dis 1996;6(3):29-31.[4]WANG LT. The cytological mechanism of Chinese herbal medicines in antagonizing liver fibrosis. Chinese J of Integrated Traditional and Western Medicine on Liver Dis 1997;7(4):249-252.[5]LI J, YU S. Study on the ultrastructure of the peritoneal stomata in humans. Acta Anat 1991;141(1):26-31.[6]LI J, LU Z, WU N, et al. A scanning electron microscopy and computer image processing morphometric study of the pharmacological regulation of patency of the peritoneal stomata. Acta Anat 1996;178(5):443-447.

  1. Traditional Chinese medicine formula Qing Huo Yi Hao as superoxide anion scavenger in high glucosetreated endothelial cells

    Institute of Scientific and Technical Information of China (English)

    Qiong xu; Bin ZHANG; Xiao-mu LI; Xin GAO

    2012-01-01

    Aim:To investigate the effects of a traditional Chinese medicine formula Qing Huo Yi Hao (QHYH)and its components on hydroxyl radical (HO·)production in vitro and the activity of QHYH against free radicals in cultured endothelial cells induced by high glucose.Methods:Hydroxyl radicals (HO·)were generated through Fenton reactions in vitro,and 5,5-dimethyl-1-pyrroline N-oxide (DMPO)was used as a spin trap to form DMPO/HO·adducts detected using electron paramagnetic resonance (EPR).Immortalized mouse cerebral microvascular endothelial (bEnd.3)cells were treated with high glucose (35 mmol/L).The free radical scavenging ability of QHYH in the cells was evaluated using EPR.Superoxide dismutase (SOD)was used to identify the free radicals scavenged by QHYH in the cells.Results:QHYH and its 8 components concentration-dependently reduced DMPO/HO· signaling.The DMPO/HO· adduct scavenging ability of QHYH was 82.2%,which was higher than each individual component.The free radical scavenging ability of 1% QHYH in high glucose-treated bEnd.3 cells was approximately 70%.In these cells,the free radicals were also specifically reduced by SOD (400 U/mL),implying that the free radicals were primarily superoxide anions.Conclusion:The results demonstrate that the QHYH formula is potent antioxidant acting as scavenge of superoxide anions in high glucose-treated endothelial cells.

  2. A system-level investigation into the mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for cardiovascular disease treatment.

    Directory of Open Access Journals (Sweden)

    Xiuxiu Li

    Full Text Available Compound Danshen Formula (CDF is a widely used Traditional Chinese Medicine (TCM which has been extensively applied in clinical treatment of cardiovascular diseases (CVDs. However, the underlying mechanism of clinical administrating CDF on CVDs is not clear. In this study, the pharmacological effect of CDF on CVDs was analyzed at a systemic point of view. A systems-pharmacological model based on chemical, chemogenomics and pharmacological data is developed via network reconstruction approach. By using this model, we performed a high-throughput in silico screen and obtained a group of compounds from CDF which possess desirable pharmacodynamical and pharmacological characteristics. These compounds and the corresponding protein targets are further used to search against biological databases, such as the compound-target associations, compound-pathway connections and disease-target interactions for reconstructing the biologically meaningful networks for a TCM formula. This study not only made a contribution to a better understanding of the mechanisms of CDF, but also proposed a strategy to develop novel TCM candidates at a network pharmacology level.

  3. Simultaneous Quantification of Ten Active Components in Traditional Chinese Formula Sijunzi Decoction Using a UPLC-PDA Method.

    Science.gov (United States)

    An, Kang; Jin-Rui, Guo; Zhen, Zhang; Xiao-Long, Wang

    2014-01-01

    Sijunzi decoction (SJZT), a traditional Chinese formula (TCMF) consisting of four herbs, has been widely used for the treatment of various gastrointestinal symptoms. However, its modernization process is hindered by the lack of a powerful quality control method that covers the major active components in the formula. The aim of this study was to establish a UPLC method for the quantitative determination of ten active components in Sijunzi decoction including ginsenoside Rg1, Re, Rb1, liquiritin, liquiritigenin, glycyrrhizic acid, atractylenolide I, atractylenolide II, atractylenolide III, and pachymic acid. Separation was achieved using an ACQUITY UPLC BEHC18 column (2.1 mm × 100 mm, 1.7  μ m) with a gradient elution program consisting of acetonitrile and 0.1% phosphoric acid solution. The detection wavelengths were set at 203, 254, 222, and 267 nm. The method was validated for linearity, accuracy, precision, limit of detection, and limit of quantification. The validated method was successfully applied to the simultaneous quantification of ten active compounds from several finished batches of SJZT. This validated that UPLC method is expected to provide a new basis for the quality control of SJZT.

  4. Selected Extracts of Chinese Herbal Medicines: Their Effect on NF-κB, PPARα and PPARγ and the Respective Bioactive Compounds

    Directory of Open Access Journals (Sweden)

    E. Rozema

    2012-01-01

    Full Text Available Chinese herbal medicinal (CHM extracts from fourteen plants were investigated in cell-based in vitro assays for their effect on nuclear factor κB (NF-κB, a key regulator of inflammation, as well as on peroxisome proliferator-activated receptors (PPARs being key regulators of genes involved in lipid and glucose metabolism. 43% of the investigated CHMs showed NF-κB inhibitory and 50% PPARα and PPARγ activating effects. Apolar extracts from cortex and flos of Albizia julibrissin Durazz. and processed rhizomes of Arisaema sp. and Pinellia ternata (Thunb. Breit. that effectively inhibited TNF-α-induced NF-κB activation and dose-dependently activated PPARα and PPARγ were further investigated. Bioassay-guided fractionation and analysis by GC-MS led to the identification of fatty acids as PPAR agonists, including linoleic and palmitic acid.

  5. Selected Extracts of Chinese Herbal Medicines: Their Effect on NF-κB, PPARα and PPARγ and the Respective Bioactive Compounds.

    Science.gov (United States)

    Rozema, E; Atanasov, A G; Fakhrudin, N; Singhuber, J; Namduang, U; Heiss, E H; Reznicek, G; Huck, C W; Bonn, G K; Dirsch, V M; Kopp, B

    2012-01-01

    Chinese herbal medicinal (CHM) extracts from fourteen plants were investigated in cell-based in vitro assays for their effect on nuclear factor κB (NF-κB), a key regulator of inflammation, as well as on peroxisome proliferator-activated receptors (PPARs) being key regulators of genes involved in lipid and glucose metabolism. 43% of the investigated CHMs showed NF-κB inhibitory and 50% PPARα and PPARγ activating effects. Apolar extracts from cortex and flos of Albizia julibrissin Durazz. and processed rhizomes of Arisaema sp. and Pinellia ternata (Thunb.) Breit. that effectively inhibited TNF-α-induced NF-κB activation and dose-dependently activated PPARα and PPARγ were further investigated. Bioassay-guided fractionation and analysis by GC-MS led to the identification of fatty acids as PPAR agonists, including linoleic and palmitic acid.

  6. Identification of adulterants in a Chinese herbal medicine by LC-HRMS and LC-MS-SPE/NMR and comparative in vivo study with standards in a hypertensive rat model

    DEFF Research Database (Denmark)

    Kesting, Julie Regitze; Huang, JingQi; Sørensen, Dan

    2010-01-01

    Based on anecdotal evidence of anti-hypertensive effect of Gold Nine Soft Capsules, an in vivo study of this complex Chinese "herbal-based" medicine was initiated. Dosage of the content of Gold Nine capsules in spontaneous hypertensive rats showed a remarkably good effect. This led to further...... of a combination of commercially purchased standards was shown to be equivalent to that of the capsule content. Adulteration of herbal remedies and dietary supplements with synthetic drugs is an increasing problem that may lead to serious adverse effects. LC-MS-SPE/NMR as a method for the rapid identification...

  7. Advance Research on Anti-gout Effects of Chinese Herbal Medicine%抗痛风中草药的研究进展

    Institute of Scientific and Technical Information of China (English)

    张小军; 谢丽莎; 唐文均; 龚志强

    2016-01-01

    ABSTRACT:With the development of society and improvement of human living standards,the incidence of gout dis-ease is increasing,accompanied with younger occurrence trend.Gout disease is caused by sodium crystals deposition in the joints and surrounding tissues,which characterized by disorders of purine metabolism.The drugs in western medicine commonly used for anti-gout are colchicine,non-steroidalanti-inflammatory drugs,adrenocorticotropic hor-mone and glucocorticoid.In recent years,Chinese herbal anti-gout medicine research has made great progress.The paper reviews the Chinese herbal anti-gout medicine.%随着社会发展和人类生活水平的提高,痛风疾病的发病率不断增加并且还伴着发病年龄出现低龄化趋势。痛风是一种以高尿酸血症导致尿酸钠晶体在关节及其周围组织沉积为特征的嘌呤代谢性疾病。在西药上常用来抗痛风的药物有秋水仙碱、非甾体类抗炎药、促肾上腺皮质激素、糖皮质激素等。近年来抗痛风药物中草药的研究也取得很大进步,本文就有关抗痛风中草药的研究进行综述。

  8. Evaluation of Hypoglycemic Efficacy of Tangningtongluo Formula, a Traditional Chinese Miao Medicine, in Two Rodent Animal Models

    Directory of Open Access Journals (Sweden)

    Long Cheng

    2014-01-01

    Full Text Available Traditional Chinese medicines largely lack adequate and scientifically rigorous evidence regarding efficacy and functional mechanisms. The present study was aimed to confirm the hypoglycemic effect of Tangningtongluo (TNTL formula, a traditional Chinese Miao medicine, in two animal models: high-fat diet and streptozotocin- (STZ- induced diabetic rats and C57BL/KsJ-db/db diabetic mice. After 4 weeks, TNTL intervention in STZ-induced diabetic rats yielded in significant improvement on the glucose tolerance test. Moreover, the islet histopathology showed that oral TNTL reduced the severity of islet necrosis in pancreases tissue. Compared with diabetic controls, a 12-week TNTL treatment regimen (dosages = 0.9, 1.8, and 3.6 g/kg in db/db mice significantly decreased fasting glucose and HbA1c. Additionally, oral glucose tolerance in TNTL-treated mice improved significantly, compared with diabetic mice receiving metformin. Finally, tissue histopathology and biochemical index evaluations revealed significant improvement in TNTL-treated mice. Taken together, our results show that TNTL exerted a strong hypoglycemic effect in two diabetic rodent animal models, preserving β-cells in the pancreas islet and reducing the risk of diabetic retinopathy and nephropathy.

  9. Hydrolysis of Glycosidic Flavonoids during the Preparation of Danggui Buxue Tang: An Outcome of Moderate Boiling of Chinese Herbal Mixture

    Directory of Open Access Journals (Sweden)

    Wendy Li Zhang

    2014-01-01

    Full Text Available Chemical change during boiling of herbal mixture is a puzzle. By using Danggui Buxue Tang (DBT, a herbal decoction that contains Astragali Radix (AR and Angelicae Sinensis Radix (ASR, we developed a model in analyzing the hydrolysis of flavonoid glycosides during the boiling of herbal mixture in water. A proper preparation of DBT is of great benefit to the complete extraction of bioactive ingredients. Boiling of DBT in water increased the solubility of AR-derived astragaloside IV, calycosin, formononetin, calycosin-7-O-β-D-glucoside, and ononin in a time- and temperature-dependent manner: the amounts of these chemicals reached a peak at 2 h. The glycosidic resides of AR, calycosin-7-O-β-D-glucoside, and ononin could be hydrolyzed during the moderate boiling process to form calycosin and formononetin, respectively. The hydrolysis efficiency was strongly affected by pH, temperature, and amount of herbs. Interestingly, the preheated herbs were not able to show this hydrolytic activity. The current results supported the rationality of ancient preparation of DBT in boiling water by moderate heat.

  10. Cytoprotective properties of traditional Chinese medicinal herbal extracts in hydrogen peroxide challenged human U373 astroglia cells.

    Science.gov (United States)

    Steele, Megan L; Truong, John; Govindaraghavan, Suresh; Ooi, Lezanne; Sucher, Nikolaus J; Münch, Gerald

    2013-04-01

    Age is the leading risk factor for many of the most prevalent and devastating diseases including neurodegenerative diseases. A number of herbal medicines have been used for centuries to ameliorate the deleterious effects of ageing-related diseases and increase longevity. Oxidative stress is believed to play a role in normal ageing as well as in neurodegenerative processes. Since many of the constituents of herbal extracts are known antioxidants, it is believed that restoring oxidative balance may be one of the underlying mechanisms by which medicinal herbs can protect against ageing and cognitive decline. Based on the premise that astrocytes are key modulators in the progression of oxidative stress associated neurodegenerative diseases, 13 herbal extracts purported to possess anti-ageing properties were tested for their ability to protect U373 human astrocytes from hydrogen peroxide induced cell death. To determine the contribution of antioxidant activity to the cytoprotective ability of extracts, total phenol content and radical scavenging capacities of extracts were examined. Polygonum multiflorum, amongst others, was identified as possessing potent antioxidant and cytoprotective properties. Not surprisingly, total phenol content of extracts was strongly correlated with antioxidant capacity. Interestingly, when total phenol content and radical scavenging capacities of extracts were compared to the cytoprotective properties of extracts, only moderately strong correlations were observed. This finding suggests the involvement of multiple protective mechanisms in the beneficial effects of these medicinal herbs.

  11. Integration of Chinese Herbal Medicine Therapy Improves Survival of Patients With Chronic Lymphocytic Leukemia: A Nationwide Population-Based Cohort Study.

    Science.gov (United States)

    Fleischer, Tom; Chang, Tung-Ti; Chiang, Jen-Huai; Hsieh, Ching-Yun; Sun, Mao-Feng; Yen, Hung-Rong

    2016-05-01

    Utilization of Chinese Medicine (CM) is not uncommon in patients with chronic lymphocytic leukemia (CLL). However, the current knowledge of the usage and efficacy of CM among CLL patients is limited. The aim of this study was to determine the impact of integrative Chinese Herbal Medicine (CHM) on the disease course of CLL and ascertain the herbal products most commonly prescribed to patients with CLL.A Taiwanese nationwide population-based study involving the use of Western medicine and CM services provided by the National Health Insurance (NHI) was conducted.An NHI Research Database-based cohort study was performed; the timeframe of the study was January 2000 to December 2010. The end of the follow-up period was defined as December 31, 2011.A total of 808 patients were diagnosed with CLL in Taiwan within the defined study period. After randomly matching for age and sex and excluding patients younger than 18 years of age, data from 616 patients were analyzed.The 2 study groups both received standard of care treatment. In addition, 1 group also received CHM. Patients who were registered as receiving other forms of CM, such as acupuncture, were excluded.Hazard ratios of mortality were used to determine the influence of CHM and the therapeutic potential of herbal products.In total, 616 CLL patients were included in the analyses. We found that the HR associated with the adjunctive use of CHM was less than half when compared to the non-CHM group (0.43, 95% CI 0.33-0.55, P < 0.0001) and that treatment-naive patients who used CHM had the lowest HR. We also established that this association between reduction in HR and CHM was dose-dependent, and the longer CHM users received prescriptions, the lower the HR (P < 0.001).We supplied data from a relatively large population that spanned a significant amount of time. Our data suggests that the treatment of CLL with adjunctive CHM may have a substantial positive impact on mortality, especially for treatment-naive patients

  12. Traditional Korean Herbal Formula Samsoeum Attenuates Adipogenesis by Regulating the Phosphorylation of ERK1/2 in 3T3-L1 Cells

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    Soo-Jin Jeong

    2015-01-01

    Full Text Available Adipogenesis is the cell differentiation process from preadipocytes into adipocytes and the critical action in the development of obesity. In the present study, we conducted in vitro analyses to investigate the inhibitory effects of Samsoeum (SSE, a traditional herbal decoction. SSE had no significant cytotoxic effect against either the undifferentiated or differentiated 3T3-L1 cells. Oil Red O staining results showed that SSE significantly inhibited fat accumulation in adipocytes. SSE treatment consistently reduced the intracellular triglyceride content in the cells. SSE significantly inactivated glycerol-3-phosphate dehydrogenase (GPDH, a major link between carbohydrate and lipid metabolisms in 3T3-L1 adipocytes, and markedly inhibited the production of leptin, an important adipokine, in differentiated cells. SSE markedly suppressed the mRNA expression of the adipogenesis-related genes peroxisome proliferator-activated receptor-gamma (PPAR-γ, CCAAT/enhancer binding protein-alpha (C/EBP-α, fatty acid synthase (FAS, lipoprotein lipase (LPL, and fatty acid binding protein 4 (FABP4. Importantly, SSE increased the phosphorylation of ERK1/2, but not p38 MAPK and JNK, in adipose cells. Overall, our results indicate that SSE exerts antiadipogenic activity and modulates expressions of adipogenesis-related genes and ERK1/2 activation in adipocytes.

  13. CST, an Herbal Formula, Exerts Anti-Obesity Effects through Brain-Gut-Adipose Tissue Axis Modulation in High-Fat Diet Fed Mice

    Directory of Open Access Journals (Sweden)

    AbuZar Ansari

    2016-11-01

    Full Text Available The brain, gut, and adipose tissue interact to control metabolic pathways, and impairment in the brain-gut-adipose axis can lead to metabolic disorders, including obesity. Chowiseungcheng-tang (CST, a herbal formulation, is frequently used to treat metabolic disorders. Here, we investigated the anti-obesity effect of CST and its link with brain-gut-adipose axis using C57BL/6J mice as a model. The animals were provided with a normal research diet (NRD or high-fat diet (HFD in absence or presence of CST or orlistat (ORL for 12 weeks. CST had a significant anti-obesity effect on a number of vital metabolic and obesity-related parameters in HFD-fed mice. CST significantly decreased the expression levels of genes encoding obesity-promoting neuropeptides (agouti-related peptide, neuropeptide Y, and increased the mRNA levels of obesity-suppressing neuropeptides (proopiomelanocortin, cocaine-and amphetamine-regulated transcript in the hypothalamus. CST also effectively decreased the expression level of gene encoding obesity-promoting adipokine (retinol-binding protein-4 and increased the mRNA level of obesity-suppressing adipokine (adiponectin in visceral adipose tissue (VAT. Additionally, CST altered the gut microbial composition in HFD groups, a phenomenon strongly associated with key metabolic parameters, neuropeptides, and adipokines. Our findings reveal that the anti-obesity impact of CST is mediated through modulation of metabolism-related neuropeptides, adipokines, and gut microbial composition.

  14. Anti‑inflammatory and antioxidant activity of the traditional herbal formula Gwakhyangjeonggi‑san via enhancement of heme oxygenase‑1 expression in RAW264.7 macrophages.

    Science.gov (United States)

    Jeong, Soo-Jin; Kim, Ohn-Soon; Yoo, Sae-Rom; Seo, Chang-Seob; Kim, Yeji; Shin, Hyeun-Kyoo

    2016-05-01

    Gwakhyangjeonggi‑san (GHJGS) is a mixture of herbal plants, including Agastache rugosa, Perilla frutescens, Angelica dahurica, Areca catechu, Poria cocos, Magnolia officinalis, Atractylodes macrocephala, Citrus reticulata, Pinellia ternata, Platycodon grandiflorum, Glycyrrhiza uralensis, Ziziphus jujuba and Zingiber officinale. GHJGS has been used for treating diarrhea‑predominant irritable bowel syndrome in traditional Korean medicine. In the present study, the anti‑inflammatory and antioxidant effects of GHJGS were investigated using the RAW 264.7 murine macrophage cell line. GHJGS significantly reduced production of the proinflammatory cytokines, tumor necrosis factor‑α, interleukin‑6 and prostaglandin E2 in lipopolysaccharide (LPS)‑stimulated macrophages. GHJGS markedly suppressed LPS‑induced phosphorylation of mitogen‑activated protein kinases, whereas it had no effect on nuclear factor‑κB activation. Furthermore, GHJGS enhanced expression of heme oxygenase‑1 and prevented the generation of reactive oxygen species in RAW 264.7 cells. These results indicate that GHJGS is a viable therapeutic agent against inflammation and oxidative stress‑associated disorders.

  15. Systems pharmacology-based dissection of mechanisms of Chinese medicinal formula Bufei Yishen as an effective treatment for chronic obstructive pulmonary disease

    Science.gov (United States)

    Li, Jiansheng; Zhao, Peng; Li, Ya; Tian, Yange; Wang, Yonghua

    2015-01-01

    The present work adopted a systems pharmacology-based approach to provide new insights into the active compounds and therapeutic targets of Bufei Yishen formula (BYF) for the treatment of chronic obstructive pulmonary disease (COPD). In addition, we established a rat model of cigarette smoke- and bacterial infection-induced COPD to validate the mechanisms of BYF action that were predicted in systems pharmacology study. The systems pharmacology model derived 216 active compounds from BYF and 195 potential targets related to various diseases. The compound-target network showed that each herbal drug in the BYF formula acted on similar targets, suggesting potential synergistic effects among these herbal drugs. The ClueGo assay, a Cytoscape plugin, revealed that most targets were related to activation of MAP kinase and matrix metalloproteinases. By using target-diseases network analysis, we found that BYF had great potential to treatment of multiple diseases, such as respiratory tract diseases, immune system, and cardiovascular diseases. Furthermore, we found that BYF had the ability to prevent COPD and its comorbidities, such as ventricular hypertrophy, in vivo. Moreover, BYF inhibited the inflammatory cytokine, and hypertrophic factors expression, protease-antiprotease imbalance and the collagen deposition, which may be the underlying mechanisms of action of BYF. PMID:26469778

  16. 使用群体辩证对猪场进行中草药保健%The health care with Chinese herbal medicine by population dialectic view in pig farm

    Institute of Scientific and Technical Information of China (English)

    张颖哲; 李静; 马志英; 牟国森

    2014-01-01

    为推广一套解决行之有效的猪场养殖、保健、预防、治疗系列思路与方法,本文采用空白对照组、化药保健组、中草药保健组、群体辩证中草药保健组、破壁酶解中草药保健组及群体辩证破壁酶解中草药保健组对猪场进行养殖管理,试验结果表明,群体辩证中草药保健组净增重显著高于中草药保健组、化药保健组和对照组,成活率也高于三个处理组,药费低于三个处理组;群体辩证破壁酶解中草药保健组的净增重显著高于其他处理组,摄食量则相反,成活率最高,料肉比和药费最低。因此,使用群体辩证对猪场进行中草药保健,尤其是破壁酶解中草药保健,对于抵制当前抗生素滥用、扭转养猪效益下滑、促进养猪场户增产增收将起到重要的实际推动。%In order to popularize a set of ideas and methods to effectively solve the breeding, health care, and disease prevention and control problems in pig farm, in the present study the pig farm was managed in six groups: a blank control group, a chemical medicine health care group, a Chinese herbal medicine health care group, a herbal health care group by population dialectic, a lyticase hydrolyzed Chinese herbal medicine health group, and a lyticase hydrolyzed Chinese herbal medicine health group by population dialectic. The results show that the net weight gain of Chi-nese herbal medicine health care group by population dialectic was obviously higher than Chinese herbal medicine health care group, chemical medicine health care group, and blank control group, the survival rate was higher than three groups above, and medicine cost was lower than three groups above; the net weight gain of lyticase hydrolyzed Chinese herbal medicine health group by population dialectic was significantly higher than all other groups, on the other hand, the feed intake was the lowest, the survival rate was highest, the feed/gain ratio

  17. Mechanisms and effects of Chinese herbal medicine delaying progression of chronic renal failure%中药延缓慢性肾功能衰竭进展的机制和效果

    Institute of Scientific and Technical Information of China (English)

    冯青; 万毅刚; 蒋春明; 王朝俊; 魏晴雪; 赵青; 姚建

    2011-01-01

    In this review, firstly,it has been discussed the mechanisms of Chinese herbal medicine ameliorating glomerulosclerosis and renal interstitial fibrosis during the progression of chronic renal failure(CRF) by improving glomerular hemodynamics turbulence, podocyte injury, transforming growth factor (TGF) -β over-expression, hyperlipidemia, macrophage infiltration, tubular epithelial myofibroblast transdifferentiation,and nephrotoxicity of proteinuria.Secondly,it has been reported the clinical effects of Chinese herbal medicine improving renal function and some clinical complications in the patients with progressive CRF through various treatments including oral administration or coloclysis of Chinese herbal medicine,oral administration combined with coloclysis of Chinese herbal medicine,and colonic dialysis combined with coloclysis of Chinese herbal medicine.Finally,it has been reviewed the beneficial influences of Chinese herbal medicine on metabolic dysequilibrium of calcium and phosphonium, microinfiammatory state, and uremic toxins in patients with uremia.%中药延缓慢性肾功能衰竭(chronic renal failure,CRF)进展的机制主要是指中药改善肾小球硬化和肾间质纤维化的作用,譬如,通过影响肾小球血流动力,减轻足细胞损伤,抑制转化生长因子-β表达,调整脂质代谢紊乱来改善肾小球硬化;通过减轻巨噬细胞浸润,抑制肾小管上皮细胞转分化,降低尿蛋白毒性来改善肾间质纤维化等.中药延缓CRF进展的临床效果主要体现在改善肾功能和某些并发症等方面,其治疗方法包括中药复方口服、中药保留灌肠、中药复方口服联合中药保留灌肠以及结肠透析联合中药保留灌肠等.另外,对于晚期CRF患者所出现的钙/磷代谢失衡、微炎症状态以及尿毒症毒素蓄积,中药也有一定的改善作用.

  18. Therapeutic Effect of Chung-Pae, an Experimental Herbal Formula, on Acute Lung Inflammation Is Associated with Suppression of NF-κB and Activation of Nrf2

    Directory of Open Access Journals (Sweden)

    Kyun Ha Kim

    2013-01-01

    Full Text Available Acute lung injury (ALI is an inflammatory disease with high mortality, but therapeutics against it is unavailable. Recently, we elaborated a formula, named Chung-pae (CP, that comprises four ethnic herbs commonly prescribed against various respiratory diseases in Asian traditional medicine. CP is being administered in aerosol to relieve various respiratory symptoms of patients in our clinic. Here, we sought to examine whether CP has a therapeutic effect on ALI and to uncover the mechanism behind it. Reporter assays show that CP suppressed the transcriptional activity of proinflammatory NF-κB and activated that of anti-inflammatory Nrf2. Similarly, CP suppressed the expression of NF-κB dependent, proinflammatory cytokines and induced that of Nrf2 dependent genes in RAW 264.7. An aerosol intratracheal administration of CP effectively reduced neutrophilic infiltration and the expression of pro-inflammatory cytokines, hallmarks of ALI, in the lungs of mice that received a prior intraperitoneal injection of lipopolysaccharide. The intratracheal CP administration concomitantly enhanced the expression of Nrf2 dependent genes in the lung. Therefore, our results evidenced a therapeutic effect of CP on ALI, in which differential regulation of the two key inflammatory factors, NF-κB and Nrf2, was involved. We propose that CP can be a new therapeutic formula against ALI.

  19. Study of the ESI and APCI interfaces for the UPLC-MS/MS analysis of pesticides in traditional Chinese herbal medicine.

    Science.gov (United States)

    Chen, Lina; Song, Fengrui; Liu, Zhiqiang; Zheng, Zhong; Xing, Junpeng; Liu, Shuying

    2014-02-01

    In this work, 53 selected pesticides of different chemical groups were extracted from Chinese herbal medicines and determined by ultra-high-performance liquid chromatography (UHPLC)-tandem mass spectrometry (MS/MS) using both electrospray ionization (ESI) and atmospheric-pressure chemical ionization (APCI). Extracts were obtained using the acetonitrile-based quick, easy, cheap, effective, rugged, and safe (QuEChERS) sample preparation technique. Cleanup was performed by dispersive solid-phase extraction using primary secondary amine, graphitized carbon black, and octadecylsilane. Two atmospheric-pressure interfaces, ESI and APCI, were checked and compared. The validation study, including detection limits, linearity, and matrix effects, was conducted on fritillaria, radix ginseng, folium isatidis, semen persicae, and flos lonicerae in multiple reaction monitoring mode. These matrices represent a variety of plants used in traditional Chinese medicine. Fritillaria and radix ginseng were chosen as representatives for roots, folium isatidis was chosen as a representative for leaves, semen persicae was chosen as a representative for seeds, and flos lonicerae was chosen as a representative for flowers. The limits of detection for pesticides were lower in the UHPLC-ESI-MS/MS method than in the UHPLC-APCI-MS/MS method. Matrix effects on the two ionizations were evaluated for the five matrices. Soft signal enhancement in UHPLC-APCI-MS/MS and signal suppression in UHPLC-ESI-MS/MS were observed.

  20. Concurrent Use of Hypnotic Drugs and Chinese Herbal Medicine Therapies among Taiwanese Adults with Insomnia Symptoms: A Population-Based Study

    Directory of Open Access Journals (Sweden)

    Kuei-Hua Lee

    2013-01-01

    Full Text Available Background. The increased practice of traditional Chinese medicine (TCM worldwide has raised concerns regarding herb-drug interactions. The purpose of our study is to analyze the concurrent use of Chinese herbal products (CHPs among Taiwanese insomnia patients taking hypnotic drugs. Methods. The usage, frequency of services, and CHP prescribed among 53,949 insomnia sufferers were evaluated from a random sample of 1 million beneficiaries in the National Health Insurance Research Database. A logistic regression method was used to identify the factors that were associated with the coprescription of a CHP and a hypnotic drug. Cox proportional hazards regressions were performed to calculate the hazard ratios (HRs of hip fracture between the two groups. Results. More than 1 of every 3 hypnotic users also used a CHP concurrently. Jia-Wei-Xiao-Yao-San (Augmented Rambling Powder and Suan-Zao-Ren-Tang (Zizyphus Combination were the 2 most commonly used CHPs that were coadministered with hypnotic drugs. The HR of hip fracture for hypnotic-drug users who used a CHP concurrently was 0.57-fold (95% CI = 0.47–0.69 that of hypnotic-drug users who did not use a CHP. Conclusion. Exploring potential CHP-drug interactions and integrating both healthcare approaches might be beneficial for the overall health and quality of life of insomnia sufferers.

  1. Concurrent Use of Hypnotic Drugs and Chinese Herbal Medicine Therapies among Taiwanese Adults with Insomnia Symptoms: A Population-Based Study.

    Science.gov (United States)

    Lee, Kuei-Hua; Tsai, Yueh-Ting; Lai, Jung-Nien; Lin, Shun-Ku

    2013-01-01

    Background. The increased practice of traditional Chinese medicine (TCM) worldwide has raised concerns regarding herb-drug interactions. The purpose of our study is to analyze the concurrent use of Chinese herbal products (CHPs) among Taiwanese insomnia patients taking hypnotic drugs. Methods. The usage, frequency of services, and CHP prescribed among 53,949 insomnia sufferers were evaluated from a random sample of 1 million beneficiaries in the National Health Insurance Research Database. A logistic regression method was used to identify the factors that were associated with the coprescription of a CHP and a hypnotic drug. Cox proportional hazards regressions were performed to calculate the hazard ratios (HRs) of hip fracture between the two groups. Results. More than 1 of every 3 hypnotic users also used a CHP concurrently. Jia-Wei-Xiao-Yao-San (Augmented Rambling Powder) and Suan-Zao-Ren-Tang (Zizyphus Combination) were the 2 most commonly used CHPs that were coadministered with hypnotic drugs. The HR of hip fracture for hypnotic-drug users who used a CHP concurrently was 0.57-fold (95% CI = 0.47-0.69) that of hypnotic-drug users who did not use a CHP. Conclusion. Exploring potential CHP-drug interactions and integrating both healthcare approaches might be beneficial for the overall health and quality of life of insomnia sufferers.

  2. Chinese Herbal Decoction Based on Syndrome Differentiation as Maintenance Therapy in Patients with Extensive-Stage Small-Cell Lung Cancer: An Exploratory and Small Prospective Cohort Study

    Directory of Open Access Journals (Sweden)

    Rui Liu

    2015-01-01

    Full Text Available Objective. To investigate the treatment effect and treatment length of Chinese herbal decoction (CHD as maintenance therapy on patients with extensive-stage small-cell lung cancer (ES-SCLC and to reflect the real syndrome differentiation (Bian Zheng practices of traditional Chinese medicine (TCM. Patients and Methods. Different CHDs were prescribed for each patient based on syndrome differentiation. The length of CHD treatment was divided into two phases for analyzing progression-free survival (PFS and postprogression survival (PPS. Results. Three hundred and fifty-seven CHDs were prescribed based on syndrome differentiation during the study period. Median PFS was significantly longer in patients who received CHD >3 months than patients who received CHD ≤3 months in the first phase (8.7 months versus 4.5 months; hazard ratio (HR, 0.52; 95% confidence interval (CI, 0.41–0.99; P=0.0009. Median PPS was significantly longer in patients who received CHD >7 months than patients who received CHD ≤7 months in the second phase (11.7 months versus 5.1 months; HR, 2.32; 95% CI, 1.90–2.74; P=0.002. Conclusion. CHD could improve PFS and PPS, which are closely related to treatment time and deepness of response of first-line therapy. In addition, CHD could improve body function and keep patients in a relatively stable state.

  3. Targeting PML-RARα and Oncogenic Signaling Pathways by Chinese Herbal Mixture Tien-Hsien Liquid in Acute Promyelocytic Leukemia NB4 Cells

    Directory of Open Access Journals (Sweden)

    Chih-Jung Yao

    2011-01-01

    Full Text Available Tien-Hsien Liquid (THL is a Chinese herbal mixture that has been used worldwide as complementary treatment for cancer patients in the past decade. Recently, THL has been shown to induce apoptosis in various types of solid tumor cells in vitro. However, the underlying molecular mechanisms have not yet been well elucidated. In this study, we explored the effects of THL on acute promyelocytic leukemia (APL NB4 cells, which could be effectively treated by some traditional Chinese remedies containing arsenic trioxide. The results showed THL could induce G2/M arrest and apoptosis in NB4 cells. Accordingly, the decrease of cyclin A and B1 were observed in THL-treated cells. The THL-induced apoptosis was accompanied with caspase-3 activation and decrease of PML-RARα fusion protein. Moreover, DNA methyltransferase 1 and oncogenic signaling pathways such as Akt/mTOR, Stat3 and ERK were also down-regulated by THL. By using ethyl acetate extraction and silica gel chromatography, an active fraction of THL named as EAS5 was isolated. At about 0.5–1% of the dose of THL, EAS5 appeared to have most of THL-induced multiple molecular targeting effects in NB4 cells. Based on the findings of these multi-targeting effects, THL might be regarding as a complementary and alternative therapeutic agent for refractory APL.

  4. 中草药制剂对獭兔肠道内环境影响的研究%Study on the effects of the Chinese herbal medicine on the intestinal environment in rex rabbit

    Institute of Scientific and Technical Information of China (English)

    左晓磊; 赵德明; 韩爱云; 赵国先

    2016-01-01

    The experiment observes the effects of the Chinese herbal medicine on the intestinal environ⁃ment of rex rabbit. 120 rex rabbits were randomly divided into 6 groups, each group was 20 rab⁃bits. The rex rabbits were fed in the same feeding environment. Treatments involved the control groupⅠ(basal diet); Ⅱ(basal plus 4 mg/kg Diclazuril); Ⅲ(basal plus 0.5% Chinese-herb), Ⅳ(basal plus 1.0%Chinese-herb), Ⅴ(basal plus 1.5% Chinese-herb), Ⅵ(basal plus 2.0% Chinese-herb). 50 days later, determination on the intestinal environment index. The results were listed as follows:①The rate of diar⁃rhea of the chinese herbal medicine group were significantly lower than the control group. The Chinese herbal medicine contains a variety of natural antimicrobial substances, and has a good preventive effect on rex rabbit. ②The Chinese herbal medicine can promote gastrointestinal peristalsis and regulation of enzyme of rex rabbit. The Chinese herbal medicine has a good role in promoting of rex rabbit intesti⁃nal environment. ③The Chinese herbal medicine can inhibit the proliferation of harmful bacteria, such as E.coli, salmonella and staphylococcus aureus, and adjusts the lactobacillus metabolism of bacteria. The Chinese herbal medicine has promote intestinal micro ecological system stability of rex rabbit.%试验研究不同水平的纯中草药饲料添加剂对生长獭兔肠道内环境的影响。采用单因素分组设计,将120只生长獭兔随机分为6组,每组4个重复,每个重复5只,在同一饲养环境下进行饲喂。第Ⅰ组为基础对照组,饲喂基础日粮;第Ⅱ组为抗生素组,在基础日粮中添加4 mg/kg的地克珠利;第Ⅲ、Ⅳ、Ⅴ、Ⅵ组为中草药饲料添加组,在基础日粮中分别添加0.5%、1.0%、1.5%、2.0%体重的中草药制剂。50 d后测定獭兔肠道内环境指标。结果表明:①试验中添加中草药制剂组的腹泻率明显低于对照组,中草药制剂含有多种

  5. The effects of an antiosteoporosis herbal formula containing epimedii herba, ligustri lucidi fructus and psoraleae fructus on density and structure of rat long bones under tail-suspension, and its mechanisms of action.

    Science.gov (United States)

    Siu, Wing-Sum; Wong, Hing-Lok; Lau, Ching-Po; Shum, Wai-Ting; Wong, Chun-Wai; Gao, Si; Fung, Kwok-Pui; Lau, Clara Bik-San; Hung, Leung-Kim; Ko, Chun-Hay; Leung, Ping-Chung

    2013-04-01

    An innovative anti-osteoporosis herbal formula containing epimedii herba, ligustri lucidi fructus and psoraleae fructus (ELP) has been previously shown its bone protecting effects in ovariectomized osteoporotic rats and also in post-menopausal osteopenic women. This study aimed to investigate the efficacy of ELP against bone loss during physical inactivity or weightlessness. A hindlimb unloading tail-suspended rat model was used for studying the effects of ELP on bone mineral density (BMD) and bone micro-architecture. For in vitro mechanistic studies, rat mesenchymal stem cells (MSCs) and mouse macrophage cells (RAW264.7) were used for studying the effects of ELP on osteogenic/adipogenic differentiations and osteoclastogenesis, respectively. Our data illustrated that ELP had a significant preventive effect against bone loss induced by tail-suspension (TS) at day 28 (p bone micro-architecture. ELP could significantly promote the osteogenesis and suppress the adipogenesis (p bone loss induced by TS through the actions of enhancing osteogenesis, suppressing adipogenesis and osteoclastogenesis.

  6. An effective solution to discover synergistic drugs for anti-cerebral ischemia from traditional Chinese medicinal formulae.

    Directory of Open Access Journals (Sweden)

    Shaojing Li

    Full Text Available Recently, the pharmaceutical industry has shifted to pursuing combination therapies that comprise more than one active ingredient. Interestingly, combination therapies have been used for more than 2500 years in traditional Chinese medicine (TCM. Understanding optimal proportions and synergistic mechanisms of multi-component drugs are critical for developing novel strategies to combat complex diseases. A new multi-objective optimization algorithm based on least angle regression-partial least squares was proposed to construct the predictive model to evaluate the synergistic effect of the three components of a novel combination drug Yi-qi-jie-du formula (YJ, which came from clinical TCM prescription for the treatment of encephalopathy. Optimal proportion of the three components, ginsenosides (G, berberine (B and jasminoidin (J was determined via particle swarm optimum. Furthermore, the combination mechanisms were interpreted using PLS VIP and principal components analysis. The results showed that YJ had optimal proportion 3(G: 2(B: 0.5(J, and it yielded synergy in the treatment of rats impaired by middle cerebral artery occlusion induced focal cerebral ischemia. YJ with optimal proportion had good pharmacological effects on acute ischemic stroke. The mechanisms study demonstrated that the combination of G, B and J could exhibit the strongest synergistic effect. J might play an indispensable role in the formula, especially when combined with B for the acute stage of stroke. All these data in this study suggested that in the treatment of acute ischemic stroke, besides restoring blood supply and protecting easily damaged cells in the area of the ischemic penumbra as early as possible, we should pay more attention to the removal of the toxic metabolites at the same time. Mathematical system modeling may be an essential tool for the analysis of the complex pharmacological effects of multi-component drug. The powerful mathematical analysis method could

  7. An effective solution to discover synergistic drugs for anti-cerebral ischemia from traditional Chinese medicinal formulae.

    Science.gov (United States)

    Li, Shaojing; Wu, Chuanhong; Chen, Jianxin; Lu, Peng; Chen, Chang; Fu, Meihong; Fang, Jing; Gao, Jian; Zhu, Li; Liang, Rixin; Shen, Xin; Yang, Hongjun

    2013-01-01

    Recently, the pharmaceutical industry has shifted to pursuing combination therapies that comprise more than one active ingredient. Interestingly, combination therapies have been used for more than 2500 years in traditional Chinese medicine (TCM). Understanding optimal proportions and synergistic mechanisms of multi-component drugs are critical for developing novel strategies to combat complex diseases. A new multi-objective optimization algorithm based on least angle regression-partial least squares was proposed to construct the predictive model to evaluate the synergistic effect of the three components of a novel combination drug Yi-qi-jie-du formula (YJ), which came from clinical TCM prescription for the treatment of encephalopathy. Optimal proportion of the three components, ginsenosides (G), berberine (B) and jasminoidin (J) was determined via particle swarm optimum. Furthermore, the combination mechanisms were interpreted using PLS VIP and principal components analysis. The results showed that YJ had optimal proportion 3(G): 2(B): 0.5(J), and it yielded synergy in the treatment of rats impaired by middle cerebral artery occlusion induced focal cerebral ischemia. YJ with optimal proportion had good pharmacological effects on acute ischemic stroke. The mechanisms study demonstrated that the combination of G, B and J could exhibit the strongest synergistic effect. J might play an indispensable role in the formula, especially when combined with B for the acute stage of stroke. All these data in this study suggested that in the treatment of acute ischemic stroke, besides restoring blood supply and protecting easily damaged cells in the area of the ischemic penumbra as early as possible, we should pay more attention to the removal of the toxic metabolites at the same time. Mathematical system modeling may be an essential tool for the analysis of the complex pharmacological effects of multi-component drug. The powerful mathematical analysis method could greatly

  8. Bitterness-masking Effects of Neotame on Five Bitter Chinese Herbal Ingredients%纽甜对5种苦味中药的掩味效果

    Institute of Scientific and Technical Information of China (English)

    张璐; 施钧瀚; 康冰亚; 高晓洁; 李学林; 刘瑞新

    2014-01-01

    This study was ai med to observe the taste-masking effects of Neotame on bitter Chinese herbal ingredients. Five kinds of herbal ingredients, which include Scutellaria baicalensis Georgi, Cortex Phellodendri chinensis, Coptis chinensis Franch, Gentiana scabra Bunge, Andrographis paniculata, were selected to measure the bitterness degree of decoctions with berberine solution as the benchmark. The decreasing of bitterness degree was used as index. Healthy volunteers were recruited to taste and compare the changes of bitterness of decoctions with the taste-masking effects of Neotame. Different concentrations of Neotame were selected in the determination of the influence on changes of bitterness. The results showed that when the concentration of Neotame was at 0.012 5‰-0.4‰, taste-masking effects of Neotame on selected herbal decoctions were in a concentration-dependent fashion. When the concentration of Neotame was 0.4‰, the reduced bitterness of S. baicalensis Georgi and Cortex P. chinensis decoctions were 1.22 and 1.77, by 70.11% and 71.88%, respectively. Three highly-bitter herbal ingredients C. chinensis Franch, G. scabra Bunge and A . paniculata were also reduced in bitter taste by 49.12%, 50.87% and 38.39%, with the bitter reduced value (△I) of 1.78, 2.02 and 1.43, respectively. It was concluded that Neotame exerted taste masking potential on bitter herbal ingredients with different bitter degrees.%目的:考察纽甜对苦味中药的掩味效果。方法:以盐酸小檗碱水溶液和黄芩、黄柏、黄连、龙胆、穿心莲5种代表性苦味中药的水煎液为苦味药物研究载体,以苦度降低值为指标,运用经典人群口尝评价法比较纽甜的掩味效果,并选取不同的浓度,考察加入掩味剂后溶液的苦度变化。结果:纽甜在其浓度为0.0125‰-0.4‰的范围内,其掩味效果随着浓度的增加随之增强。加入0.4‰的纽甜后,属于苦类的黄芩和黄柏药液的苦度

  9. Fo Shou San, an ancient Chinese herbal decoction, protects endothelial function through increasing endothelial nitric oxide synthase activity.

    Directory of Open Access Journals (Sweden)

    Cathy W C Bi

    Full Text Available Fo Shou San (FSS is an ancient herbal decoction comprised of Chuanxiong Rhizoma (CR; Chuanxiong and Angelicae Sinensis Radix (ASR; Danggui in a ratio of 2:3. Previous studies indicate that FSS promotes blood circulation and dissipates blood stasis, thus which is being used widely to treat vascular diseases. Here, we aim to determine the cellular mechanism for the vascular benefit of FSS. The treatment of FSS reversed homocysteine-induced impairment of acetylcholine (ACh-evoked endothelium-dependent relaxation in aortic rings, isolated from rats. Like radical oxygen species (ROS scavenger tempol, FSS attenuated homocysteine-stimulated ROS generation in cultured human umbilical vein endothelial cells (HUVECs, and it also stimulated the production of nitric oxide (NO as measured by fluorescence dye and biochemical assay. In addition, the phosphorylation levels of both Akt kinase and endothelial NO synthases (eNOS were markedly increased by FSS treatment, which was abolished by an Akt inhibitor triciribine. Likewise, triciribine reversed FSS-induced NO production in HUVECs. Finally, FSS elevated intracellular Ca(2+ levels in HUVECs, and the Ca(2+ chelator BAPTA-AM inhibited the FSS-stimulated eNOS phosphorylation. The present results show that this ancient herbal decoction benefits endothelial function through increased activity of Akt kinase and eNOS; this effect is causally via a rise of intracellular Ca(2+ and a reduction of ROS.

  10. Long-term treatment with shengmai san-derived herbal supplement (Wei Kang Su) enhances antioxidant response in various tissues of rats with protection against carbon tetrachloride hepatotoxicity.

    Science.gov (United States)

    Leong, Pou Kuan; Chen, Na; Chiu, Po Yee; Leung, Hoi Yan; Ma, Chung Wah; Tang, Qing Tao; Ko, Kam Ming

    2010-04-01

    Wei Kang Su (WKS) is a commercial herbal product based on a Chinese herbal formula, Shengmai San. Here, we investigated the effects of long-term treatment with WKS on mitochondrial antioxidant status and functional ability, as well as heat shock protein (Hsp) 25/70 production, in various tissues of rats. WKS treatment enhanced mitochondrial antioxidant status and ATP generation capacity, as well as Hsp 25/70 production in various rat tissues. WKS treatment suppressed plasma reactive oxygen metabolite levels and protected against carbon tetrachloride hepatotoxicity in rats. Long-term WKS treatment may prevent diseases by enhancing the resistance of mitochondria to oxidative stress.

  11. Standardised versus individualised multiherb Chinese herbal medicine for oligomenorrhoea and amenorrhoea in polycystic ovary syndrome: a randomised feasibility and pilot study in the UK

    Science.gov (United States)

    Flower, Andrew; Prescott, Philip; Wing, Trevor; Moore, Michael; Lewith, George

    2017-01-01

    Objectives To explore feasibility of a randomised study using standardised or individualised multiherb Chinese herbal medicine (CHM) for oligomenorrhoea and amenorrhoea in women with polycystic ovary syndrome (PCOS), to pilot study methods and to obtain clinical data to support sample size calculations. Design Prospective, pragmatic, randomised feasibility and pilot study with participant and practitioner blinding. Setting 2 private herbal practices in the UK. Participants 40 women diagnosed with PCOS and oligomenorrhoea or amenorrhoea following Rotterdam criteria. Intervention 6 months of either standardised CHM or individualised CHM, 16 g daily taken orally as a tea. Main outcome measures Our primary objective was to determine whether oligomenorrhoea and amenorrhoea were appropriate as the primary outcome measures for the main study. Estimates of treatment effects were obtained for menstrual rate, body mass index (BMI), weight and hirsutism. Data were collected regarding safety, feasibility and acceptability. Results Of the 40 participants recruited, 29 (72.5%) completed the study. The most frequently cited symptoms of concern were hirsutism, weight and menstrual irregularity. Statistically significant improvements in menstrual rates were found at 6 months within group for both standardised CHM (mean difference (MD) 0.18±0.06, 95% CI 0.06 to 0.29; p=0.0027) and individualised CHM (MD 0.27±0.06, 95% CI 0.15 to 0.39; phirsutism scores found within group for both groups were not statistically significant between group (p=0.09). Liver and kidney function and adverse events data were largely normal. Participant feedback suggests changing to tablet administration could facilitate adherence. Conclusions A CHM randomised controlled trial for PCOS is feasible and preliminary data suggest that both individualised and standardised multiherb CHMs have similar safety profiles and clinical effects on promoting menstrual regularity. These data will inform the design of

  12. 中草药饲料添加剂在肉鸡生产中的应用研究%Application Research on Chinese Herbal Medicine Fodder Additive in Broilers' Production

    Institute of Scientific and Technical Information of China (English)

    任艳

    2009-01-01

    Summarized the role of Chinese herbal medicine fodder additive mechanism. Introduced the role of promoting growth, improving the quality of chicken, broiler breeding to improve performance, increase the capacity of anti-stress, enhance immunity and resistance to disease. Analyzed the current problems about Chinese herbal feed additive, and viewed the development direction of it in future.%阐述了中草药饲料添加剂的作用机理,指出其对肉鸡具有促进生长、提高鸡肉品质、提高肉种鸡繁殖性能、提高抗应激能力、增强免疫力和抗病力的作用,分析了当前中草药饲料添加剂存在的问题,并对中草药饲料添加剂的发展方向进行了展望.

  13. 甘肃省中草药生产现状及可持续发展对策%PRESENT SITUATION OF CHINESE HERBAL MEDICINE PRODUCTION AND SUSTAINABLE DEVELOPMENT STRATEGIES IN GANSU PROVINCE

    Institute of Scientific and Technical Information of China (English)

    韩多; 王海鹏; 汪玉萍; 陆桂芝

    2011-01-01

    该文概述了甘肃省气候资源、中草药生产现状、市场背景,结合现阶段生产中存在的问题有针对性地提出了可持续发展的对策,使甘肃中草药产业发展形成具有强大竞争力的现代产业,成为甘肃经济发展新的增长点.%This paper summarized the climate resource, present production situation and market background of Chinese herbal medicine in Cansu province, put forward the countermeasures of sustainable development combined with the present production problems, which would make the Cansu Chinese herbal medicine industry development become the modern industry with strong competitiveness and a new growth point of economic development in Cansu province.

  14. A Research on Control ofAlternaria Panax Whetz by Different Chinese Herbal Medicines%不同中药材对三七黑斑病病原Alternaria panax Whetz抑制作用研究

    Institute of Scientific and Technical Information of China (English)

    陈昱君; 王勇; 刘云芝; 杨建忠; 朱云飞

    2012-01-01

    The paper studies the control ofAlternaria Panax ginseng (Alternaria Panax whetz) byusingdifferent Chinese herbal medicines through antibacterial experiment and field resistance identification, screens out Chinese herbal medicines that can be mixed plant with Panax notoginseng such as Herba Lycopi, Kaempferia galanga L, Radix Ophiopogonis, Rhizoma Polygonati Odorati the results could provide the scientific basis for biodiversity control ofPanax notoginseng black spot disease.%通过不同中药材对黑斑病病原Alternaria panax Whetz.室内抑菌试验研究及病原田间致病性鉴定,筛选出可与三七混种的中药材品种泽兰、山萘、麦冬、玉竹。

  15. The Empirical Research on Development of E-commerce Logistics System of Chinese Herbal Medicine in Gansu%甘肃中药材电子商务物流体系发展实证研究

    Institute of Scientific and Technical Information of China (English)

    罗中华; 梁婷; 吴明蔚; 张翔

    2016-01-01

    The paper constructed an operating model of E-commerce logistics of Chinese herbal medicine in Gansu with the use of domestic and international theory. Besides, it also measured the development status of E-commerce logistics of Chinese herbal medicine in Gansu with fuzzy evaluation method based on survey data of 244 enterprises in Gansu. The result is: First, the model contains four dimension factors which are information technology, E-business application, in-formation management and function of logistics of Chinese herbal medicine, it is a reasonable frame structure which de-scribes E-commerce logistics of Chinese herbal medicine. The second, the overall development level of E-commerce logistics of Chinese herbal medicine is still in the early Intermediate period of the stage, there is large room for improvement, its logistics function is the key issue which restricts and affects its logistics system construction. The third, information technol-ogy is the support system of E-logistics of Chinese herbal medicine, it shall be fully embedded in the whole process of E-commerce logistics of Chinese herbal medicine, and only effective coordination of every model can improve the logistics efficiency of Chinese herbal medicines. The paper proposed countermeasures which can promote the E-commerce logistics based on the research results.%借鉴国内外理论构建了甘肃中药材电子商务物流运行模型,在对甘肃244家企业调查数据基础上用模糊评价法对甘肃中药材电子商务物流发展状况进行测度。结果是:第一,该模型包含中药材物流信息技术、电子商务应用,信息化管理和中药材物流功能四个维度因子,是一个描述中药材电子商务物流理论的合理框架结构。第二,甘肃中药材电子商务物流整体发展水平还处于初中期阶段,有较大的提升空间,其中物流功能目前是制约和影响物流体系建设的关键问题。第三,信息技术是中药

  16. An in vitro based investigation of the cytotoxic effect of water extracts of the Chinese herbal remedy LD on cancer cells

    Directory of Open Access Journals (Sweden)

    Jones Lucy A

    2009-09-01

    Full Text Available Abstract Background Long Dan Xie Gan Wan (LD, a Chinese herbal remedy formulation, is traditionally used to treat a range of conditions, including gall bladder diseases, hepatitis, hyperthyroidism, migraines but it is not used for the management or treatment of cancer. However some of its herbal constituents, specifically Radix bupleuri, Radix scutellariae and Rhizoma alismatis have been shown to inhibit the growth of cancer cells. Thus, the aim of the study was to investigate the impact of LD on cancer cells in vitro. Methods HL60 and HT29 cancer cell lines were exposed to water extracts of LD (1:10, 1:50, 1:100 and/or 1:1000 prepared from a 3 mg/30 ml stock and for both cell lines growth, apoptotic induction, alterations in cell cycle characteristics and genotoxicity were investigated. The specificity of the action of LD on these cancer cell lines was also investigated by determining its effect on human peripheral blood lymphocytes. Preliminary chemical analysis was carried out to identify cytotoxic constituents of LD using HPLC and LCMS. Results LD was significantly cytotoxic to, and induced apoptosis in, both cell lines. Apoptotic induction appeared to be cell cycle independent at all concentrations of LD used (1:10, 1:50 and 1:100 for the HL60 cell lines and at 1:10 for the HT29 cell line. At 1:50 and 1:100 apoptotic induction by LD appeared to be cell cycle dependent. LD caused significant genotoxic damage to both cell lines compared to their respective controls. The specificity study showed that LD exerted a moderate cytotoxic action against non-proliferating and proliferating blood lymphocytes but not apoptosis. Chemical analysis showed that a number of fractions were found to exert a significant growth inhibitory effect. However, the molecular weights of compounds within these fractions did not correspond to those from the herbal constituents of LD. Conclusion It is possible that LD may have some chemotherapeutic potential. However

  17. An Integrated Strategy for Global Qualitative and Quantitative Profiling of Traditional Chinese Medicine Formulas: Baoyuan Decoction as a Case.

    Science.gov (United States)

    Ma, Xiaoli; Guo, Xiaoyu; Song, Yuelin; Qiao, Lirui; Wang, Wenguang; Zhao, Mingbo; Tu, Pengfei; Jiang, Yong

    2016-12-07

    Clarification of the chemical composition of traditional Chinese medicine formulas (TCMFs) is a challenge due to the variety of structures and the complexity of plant matrices. Herein, an integrated strategy was developed by hyphenating ultra-performance liquid chromatography (UPLC), quadrupole time-of-flight (Q-TOF), hybrid triple quadrupole-linear ion trap mass spectrometry (Qtrap-MS), and the novel post-acquisition data processing software UNIFI to achieve automatic, rapid, accurate, and comprehensive qualitative and quantitative analysis of the chemical components in TCMFs. As a proof-of-concept, the chemical profiling of Baoyuan decoction (BYD), which is an ancient TCMF that is clinically used for the treatment of coronary heart disease that consists of Ginseng Radix et Rhizoma, Astragali Radix, Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle, and Cinnamomi Cortex, was performed. As many as 236 compounds were plausibly or unambiguously identified, and 175 compounds were quantified or relatively quantified by the scheduled multiple reaction monitoring (sMRM) method. The findings demonstrate that the strategy integrating the rapidity of UNIFI software, the efficiency of UPLC, the accuracy of Q-TOF-MS, and the sensitivity and quantitation ability of Qtrap-MS provides a method for the efficient and comprehensive chemome characterization and quality control of complex TCMFs.

  18. An Integrated Strategy for Global Qualitative and Quantitative Profiling of Traditional Chinese Medicine Formulas: Baoyuan Decoction as a Case

    Science.gov (United States)

    Ma, Xiaoli; Guo, Xiaoyu; Song, Yuelin; Qiao, Lirui; Wang, Wenguang; Zhao, Mingbo; Tu, Pengfei; Jiang, Yong

    2016-12-01

    Clarification of the chemical composition of traditional Chinese medicine formulas (TCMFs) is a challenge due to the variety of structures and the complexity of plant matrices. Herein, an integrated strategy was developed by hyphenating ultra-performance liquid chromatography (UPLC), quadrupole time-of-flight (Q-TOF), hybrid triple quadrupole-linear ion trap mass spectrometry (Qtrap-MS), and the novel post-acquisition data processing software UNIFI to achieve automatic, rapid, accurate, and comprehensive qualitative and quantitative analysis of the chemical components in TCMFs. As a proof-of-concept, the chemical profiling of Baoyuan decoction (BYD), which is an ancient TCMF that is clinically used for the treatment of coronary heart disease that consists of Ginseng Radix et Rhizoma, Astragali Radix, Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle, and Cinnamomi Cortex, was performed. As many as 236 compounds were plausibly or unambiguously identified, and 175 compounds were quantified or relatively quantified by the scheduled multiple reaction monitoring (sMRM) method. The findings demonstrate that the strategy integrating the rapidity of UNIFI software, the efficiency of UPLC, the accuracy of Q-TOF-MS, and the sensitivity and quantitation ability of Qtrap-MS provides a method for the efficient and comprehensive chemome characterization and quality control of complex TCMFs.

  19. Systems-Pharmacology Dissection of Traditional Chinese Medicine Compound Saffron Formula Reveals Multi-scale Treatment Strategy for Cardiovascular Diseases

    Science.gov (United States)

    Liu, Jianling; Mu, Jiexin; Zheng, Chunli; Chen, Xuetong; Guo, Zihu; Huang, Chao; Fu, Yingxue; Tian, Guihua; Shang, Hongcai; Wang, Yonghua

    2016-01-01

    Cardiovascular diseases (CVDs) have been regarding as “the world’s first killer” of human beings in recent years owing to the striking morbidity and mortality, the involved molecular mechanisms are extremely complex and remain unclear. Traditional Chinese medicine (TCM) adheres to the aim of combating complex diseases from an integrative and holistic point of view, which has shown effectiveness in CVDs therapy. However, system-level understanding of such a mechanism of multi-scale treatment strategy for CVDs is still difficult. Here, we developed a system pharmacology approach with the purpose of revealing the underlying molecular mechanisms exemplified by a famous compound saffron formula (CSF) in treating CVDs. First, by systems ADME analysis combined with drug targeting process, 103 potential active components and their corresponding 219 direct targets were retrieved and some key interactions were further experimentally validated. Based on this, the network relationships among active components, targets and diseases were further built to uncover the pharmacological actions of the drug. Finally, a “CVDs pathway” consisted of several regulatory modules was incorporated to dissect the therapeutic effects of CSF in different pathological features-relevant biological processes. All this demonstrates CSF has multi-scale curative activity in regulating CVD-related biological processes, which provides a new potential way for modern medicine in the treatment of complex diseases. PMID:26813334

  20. 蓖麻粗毒蛋白中草药解毒剂的筛选%Screening on Chinese herbal medicines antidotes to raw ricin

    Institute of Scientific and Technical Information of China (English)

    孙媚华; 陈迁; 宋光泉

    2014-01-01

    为了从31种中草药中筛选出对蓖麻粗毒蛋白具有较好解毒效果的中草药提取物,采用5种不同提取方法提取中草药有效成分,以小白鼠为试验对象,就31种中草药乙醇提取物对蓖麻毒蛋白中毒小鼠的解毒效果进行了粗筛,并就5种不同提取方法提取中草药提取液对蓖麻毒蛋白中毒小鼠的解毒效果进行了比较。结果表明,31种中草药乙醇提取物中,筛选出解毒效果较好的大黄、连翘、板蓝根、防风、白芍、附子、龙血竭、升麻(广东)和升麻(西安)等9种中草药;又从这9种中草药乙醇提取物中进一步筛选出解毒效果好且效果稳定的板蓝根、白芍、龙血竭和升麻(西安)等4种中草药;在5种提取方法中,以超声波丙酮提取法提取的中草药的解毒效果最好,超声波乙醇提取法次之,超声波水提取法效果最差;而在板蓝根、白芍、龙血竭和升麻(西安)等4种中草药提取液中,则以白芍提取液的解毒效果最佳,升麻(西安)的解毒效果最差。由此可以证明,白芍,龙血竭,板蓝根和升麻(西安)为极具潜力的蓖麻粗毒蛋白中草药解毒剂。%In order to screen out Chinese herb extracts from 31 kinds of Chinese medicinal herbs herbal which have good antidotal effect on raw ricin , five different extraction methods were investigated .Mice were used as experimental subjects , 31 kinds of herbal ethanol extracts were used to sieve coarsely by the detoxifying effect of ricin poisoning on mice .The detoxifying effects of the Chinese herb extracts extracted by five different methods were compared on ricin poisoned mice .The results showed that nine kinds of Chinese medicinal herbs were found to have good detoxification from 31 kinds of herbal ethanol extracts , for example Rhubarb , Forsythia , Radix , Divaricate saposhnikovia root , White paeony root , Radix aconiti lateralis preparata , Resina

  1. Micromorphological comparative identification between several Chinese herbal medicines and their counterfeits%几种中药材及其混伪品的微性状对比鉴别

    Institute of Scientific and Technical Information of China (English)

    马逾英; 卢晓琳; 翟萌; 杨莹

    2012-01-01

    目的:对当前市场上流通的几种中药材混伪品进行真伪对比鉴别.方法:采用微性状鉴定法,借助解剖镜、扫描仪器进行药材外形、表面、断面等特征的观察,拍摄照片或保存图片.结果:找出了灰毡毛忍冬与细毡毛忍冬、孜然、车前子、菟丝子、白芥子、丹参等中药材与其混伪品微性状特征的主要区别.结论:为相关中药材的真伪鉴别提供了参考依据,并为同类研究提供借鉴.%Objective: To identify comparatively several commercial Chinese herbal medicines and their counterfeits. Method: Hie micromorphological characters were identified. The shape, surface, section and other characters of the medicinal materials were identified by using anatomical lens and scanning apparatus. Pictures were taken and saved. Result: Main micromorphological differences between several Chinese herbal medicine including Lonicera macranthoides, L. similis, Cummum cyminum, Plantago asiatica, Cuscuta chinensis, Sinapis alba, Salvia miltiorrhua and their counterfeits were identified. Conclusion: The reference for the authenticity identification of Chinese herbal medicine and helpful experiences for the research of the same subject were provided.

  2. Characterization of the Principal Constituents of Danning Tablets, a Chinese Formula Consisting of Seven Herbs, by an UPLC-DAD-MS/MS Approach

    Directory of Open Access Journals (Sweden)

    Changsen Zhan

    2016-05-01

    Full Text Available Danning Tablets are a traditional Chinese formula showing broad clinical applications in hepatobiliary diseases and containing a diversity of bioactive chemicals. However, the chemical profiling of the formula, which serves as the material foundation of its efficacy, is really a big challenge as Danning Tablets consist of seven herbs from different origins. An ultra-performance liquid chromatography coupled to diode array detection and electrospray ionization mass spectrometry (UPLC-DAD-ESI-MS/MS approach was developed to characterize the principal polyphenol constituents in the formula. As a result, a total of 32 constituents, including 14 anthraquinones and their glucosides, four anthrones, two naphthalene glycosides, two stilbenes and 10 flavonoids were identified based on their retention time, UV absorption and MS/MS fragmentation patterns. The sources of these compounds were also illustrated. Most of the bioactive anthraquinone derivatives were found in Rhei Radix et Rhizoma or Polygoni Cuspidati Rhizoma et Radix, which are the Emperor drugs in the formula for its clinic usage. These findings indicate the merit of using this integrated UPLC-DAD-ESI-MS/MS approach to rapidly illustrate the chemical foundation of complex formulas. The present study will facilitate the quality control of Danning Tablet formulas as well as the individual herbs.

  3. Characterization of the Principal Constituents of Danning Tablets, a Chinese Formula Consisting of Seven Herbs, by an UPLC-DAD-MS/MS Approach.

    Science.gov (United States)

    Zhan, Changsen; Xiong, Aizhen; Shen, Danping; Yang, Li; Wang, Zhengtao

    2016-05-14

    Danning Tablets are a traditional Chinese formula showing broad clinical applications in hepatobiliary diseases and containing a diversity of bioactive chemicals. However, the chemical profiling of the formula, which serves as the material foundation of its efficacy, is really a big challenge as Danning Tablets consist of seven herbs from different origins. An ultra-performance liquid chromatography coupled to diode array detection and electrospray ionization mass spectrometry (UPLC-DAD-ESI-MS/MS) approach was developed to characterize the principal polyphenol constituents in the formula. As a result, a total of 32 constituents, including 14 anthraquinones and their glucosides, four anthrones, two naphthalene glycosides, two stilbenes and 10 flavonoids were identified based on their retention time, UV absorption and MS/MS fragmentation patterns. The sources of these compounds were also illustrated. Most of the bioactive anthraquinone derivatives were found in Rhei Radix et Rhizoma or Polygoni Cuspidati Rhizoma et Radix, which are the Emperor drugs in the formula for its clinic usage. These findings indicate the merit of using this integrated UPLC-DAD-ESI-MS/MS approach to rapidly illustrate the chemical foundation of complex formulas. The present study will facilitate the quality control of Danning Tablet formulas as well as the individual herbs.

  4. Analysis of the adverse drug reaction of the Chinese herbal%活血化瘀中药的不良反应分析

    Institute of Scientific and Technical Information of China (English)

    白宇明; 魏国义

    2013-01-01

    目的 分析活血化瘀中药的不良反应发生情况,促进临床合理用药.方法 通过以中药“不良反应”为关键词,检索CHKD期刊全文数据中1998-2011年国内所有文献,查阅中药致不良反应文献的原文,并进行分析.结果 15种常用活血化瘀基本中药引起的12类不良反应及药源性疾病共计203例,其中累及系统主要为泌尿系统62例,呼吸系统47例,皮肤症状27例,急性中毒13例和循环系统12例.引起不良反应较多的药物为斑蝥(6种)、水蛭、丹参、马钱子(各5种),当归、川芎、乳香、三七(各3种).年龄越大,活血化瘀中草药不良反应构成比越高.女性活血化瘀中草药不良反应构成比较男性高.结论 活血化瘀中药不良反应分类繁多,临床表现多种多样,应引起医务人员和广大患者的重视.%Objective To analyze the adverse drug reaction of blood-activating and stasis-resoloing Chinese herbal medicine.And in order to promote the clinical reasonable using medicine.Methods "Adverse drug reaction" was as the key words,all literature of full text data the CHKD journal from 1998 to 2011 were retrieved,literature of adverse reactions caused by the original inspection Chinese medicine were checked.Results A total of 15 kinds of commonly used blood circulation Chinese medicine caused 12 adverse reactions and drug-induced disease was 203 cases,involving 62 cases of the urinary system,47 cases of the respiratory system,27 cases of skin symptoms,13 cases of acute poisoning and cyclesystem in 12 cases.Drugs to cause adverse reactions were cantharidin (6 species),leeches,Salvia,horse vomica (5),Angelica,Chuanxiong,frankincense,Panax (3).The older,the higher the ratio of adverse reactions of Chinese herbal medicine.The female had higher incidence than men.Conclusion Traditional Chinese medicine has adverse classification and diverse clinical manifestations.The medical staff and the majority of patients should pay more attention on

  5. Progress on Antiplasmid Effect of Chinese Herbal Medicine%中草药消除细菌耐药性质粒研究进展

    Institute of Scientific and Technical Information of China (English)

    杨帆; 杨玉荣; 赵振升; 孔涛; 王国永

    2013-01-01

    常见病原微生物对抗微生物药物的耐药性正逐渐增加,已引起国内外学者的广泛关注。目前研究者一致认为抗微生物药物的滥用及随之产生的选择性压力是许多耐药菌出现的最主要原因。而从基因基础考虑,耐药性的产生则主要与质粒有关,质粒作为染色体外的 DNA 序列能够将耐药基因传递给环境中的其他细菌,从而引起多重耐药菌的出现。细菌耐药质粒自发消失的几率很低,但一些中草药能够使该几率增加。论文就中草药的耐药质粒消除作用及其机理进行综述。%The increasing antimicrobial resistance of common pathogens has led to a growing concern both at home and abroad.The overuse of antimicrobials and consequent antimicrobial selection pressure are thought to be the most important factors contributing to the appearance of different kinds of resistant mi-crobes.The genetical basis of resistance is often the plasmid,which can be transferred to other bacteria in the environment of the recipient,and these extrachromosomal DNA sequences can be responsible for the e-mergence of multiple resistance to antimicrobials.Plasmid may be lost spontaneously in a very low fre-quency,but certain effects,such as some Chinese herbal medicines,can increase the probability of plasmid loss.A brief review of literature on the antiplasmid effect and the mechanisms of some Chinese herbal medicines was made.

  6. Efficacy and safety of the Chinese herbal medicine shuganjieyu with and without adjunctive repetitive transcranial magnetic stimulation (rTMS) for geriatric depression: a randomized controlled trial

    Science.gov (United States)

    XIE, Minmin; JIANG, Wenhai; YANG, Haibo

    2015-01-01

    Background Pharmacological treatment of geriatric depression is often ineffective because patients cannot tolerate adequate doses of antidepressant medications. Aim Examine the efficacy and safety of shuganjieyu – the first Chinese herbal medicine approved for the treatment of depression by China’s drug regulatory agency -- with and without adjunctive treatment with repetitive transcranial magnetic stimulation (rTMS) in the treatment of geriatric depression. Methods Sixty-five inpatients 60 or older who met ICD-10 criteria for depression were randomly assigned to an experimental group (shuganjieyu + rTMS) (n=36) or a control group (shuganjieyu + sham rTMS)(n=29). All participants received 4 capsules of shuganjieyu daily for 6 weeks. rTMS (or sham rTMS) was administered 20 minutes daily, five days a week for 4 weeks. Blinded raters used the Hamilton Rating Scale for Depression (HAMD-17) and the Treatment Emergent Symptom Scale to assess clinical efficacy and safety at baseline and 1, 2, 4, and 6 weeks after starting treatment. Over the six-week trial, there was only one dropout from the experimental group and two dropouts from the control group. Results None of the patients had serious side effects, but 40% in the experimental group and 50% in the control group experienced minor side effects that all resolved spontaneously. Both groups showed substantial stepwise improvement in depressive symptoms over the 6 weeks. Repeated measures ANOVA found no differences between the two groups. After 6 weeks, 97% of the experimental group had experienced a 25% or greater drop in the level of depression, but only 20% had experience a 50% or greater drop in the level of depression; the corresponding values in the control group were 96% and 19%. There were some minor, non-significant differences in the onset of the treatment effect between the different types of depressive symptoms, but by the second week of treatment all five HAMD-17 subscale scores had improved significantly

  7. Traditional Chinese Medicine-Based Network Pharmacology Could Lead to New Multicompound Drug Discovery

    Directory of Open Access Journals (Sweden)

    Jian Li

    2012-01-01

    Full Text Available Current strategies for drug discovery have reached a bottleneck where the paradigm is generally “one gene, one drug, one disease.” However, using holistic and systemic views, network pharmacology may be the next paradigm in drug discovery. Based on network pharmacology, a combinational drug with two or more compounds could offer beneficial synergistic effects for complex diseases. Interestingly, traditional chinese medicine (TCM has been practicing holistic views for over 3,000 years, and its distinguished feature is using herbal formulas to treat diseases based on the unique pattern classification. Though TCM herbal formulas are acknowledged as a great source for drug discovery, no drug discovery strategies compatible with the multidimensional complexities of TCM herbal formulas have been developed. In this paper, we highlighted some novel paradigms in TCM-based network pharmacology and new drug discovery. A multiple compound drug can be discovered by merging herbal formula-based pharmacological networks with TCM pattern-based disease molecular networks. Herbal formulas would be a source for multiple compound drug candidates, and the TCM pattern in the disease would be an indication for a new drug.

  8. 三种复方中药对鲫鱼肝脏抗氧化功能的影响%Effect of three kinds of Chinese herbal compounds on antioxidation capability of liver in Crucian carp

    Institute of Scientific and Technical Information of China (English)

    王瑞雪; 王荻; 李绍戊; 卢彤岩; 刘红柏

    2012-01-01

    In this study, the antioxidation capacity of liver in Crucian carp (one-year old) was investigated after feeding with three kinds of Chinese herbal compounds(they were numbered AB, CD and AH) continuously for 28 days. The control group was set at the same time. Two percents of fish body weight were fed at 20℃ every day during the experiment. Then the livers were sampled to detect the four anti-oxidative indexes including SOD, MDA, GSH-PX and T-AOC. The results showed that testing groups exhibited a significantly higher level of SOD activity while a lower level of MDA compared to control group. And there was a significant difference between the AB, CD groups and the control group (P<0.05). The GSH-PX activities were higher in the three testing groups compared to the control group, with a significant difference (P<0.05) between the AH, CD groups and the control group. The three kinds of Chinese herbal compounds could increase the total antioxidant capacity (T-AOC) obviously, especially in AB and CD groups. Based on the study results mentioned above, these three formula compounds could increase the liver anti-oxidative capacity in the Crucian carp, and CD group had the best effect.%采用三种复方中药(编号分别为AB、CD和AH)分别饲喂1龄鲫鱼28 d,同时设置空白对照组,以探讨所用方剂对鲫鱼肝脏中抗氧化功能的影响.试验期间水温20℃,每天按照体重的2.0%投喂制备的饲料.采集鲫鱼肝脏,检测超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-PX)、总抗氧化能力(T-AOC)四个代表性抗氧化指标.结果表明,三种复方中药组SOD活性均显著高于对照组.MDA含量均低于对照组,其中AB、CD组与对照组差异显著(P<0.05).GSH-PX活性均高于对照组,其中AH、CD组与对照组差异显著(P<0.05).三种复方中药均能提高T-AOC,其中AB、CD组提高效果显著(P<0.05).所选的三种复方中药均对鲫鱼肝脏抗氧化能力有促进作用,其中CD组方效果最好.

  9. Gentiana scabra Bunge. Formula for Herpes Zoster: Biological Actions of Key Herbs and Systematic Review of Efficacy and Safety.

    Science.gov (United States)

    Wang, Kaiyi; Coyle, Meaghan E; Mansu, Suzi; Zhang, Anthony Lin; Xue, Charlie Changli

    2017-01-12

    This study reviewed the biological action of key herbs and evaluated systematically the efficacy and safety of oral Gentiana formula for herpes zoster (HZ). Experimental studies relevant to HZ were identified in PubMed. Randomized controlled trials using Gentiana formula for HZ were identified from nine English and Chinese databases. The primary outcome was evaluation of pain. Potential risk of bias was assessed. Meta-analysis was conducted using mean difference or risk ratio with 95% confidence intervals. Key herbs Gentiana scabra Bunge, Gentiana triflora Pall, Scutellaria baicalensis Georgi, and Gardenia jasminoides Ellis have shown antiinflammatory actions through inhibition of inflammatory cytokines and pro-inflammatory enzymes. Twenty-six clinical studies, involving 2955 participants, were included. Modified Gentiana formula resolved pain earlier than pharmacotherapy when used alone or combined with topical Chinese herbal medicine. Incidence of postherpetic neuralgia was lower (risk ratio 0.14, 95% confidence interval 0.03 to 0.74) with modified Gentiana formula plus topical Chinese herbal medicine. Mild adverse events were reported. Antiinflammatory actions of key herbs of Gentiana formula may explain clinical benefit in hastening pain relief and decreasing postherpetic neuralgia. Few adverse events were reported. Findings were limited by study quality and diversity in intervention and comparator dosage. Copyright © 2017 John Wiley & Sons, Ltd.

  10. Constituents of the anti-asthma herbal formula ASHMITM synergistically inhibit IL-4 and IL-5secretion by murine Th2 memory cells, and eotaxin by human lung fibroblasts in vitro

    Institute of Scientific and Technical Information of China (English)

    Bolleddula Javaprakasam; Nan Yang; Ming-Chun Wen; Rong Wang; Joseph Goldfarb; Hugh Sampson; Xiu-Min Li

    2013-01-01

    OBJECITVE:Anti-asthma herbal medicine intervention (ASHMITM),a combination of three traditional Chinese medicinal herbs developed in our laboratory,has demonstrated efficacy in both mouse models of allergic asthma,and a double-blind placebo-controlled clinical trial in patients with asthma.This study was designed to determine if the anti-inflammatory effects of individual herbal constituents of ASHMITM exhibited synergy.METHODS:Effects of ASHMI and its components aqueous extracts of Lingzhi (Ganoderma lucidum),Kushen (Sophora flavescens) and Gancao (Glycyrrhiza uralensis),on Th2 cytokine secretion by murine memory Th2 cells (D10.G4.1) and eotaxin-1 secretion by human lung fibroblast (HLF-1) cells were determined by measuring levels in culture supernatants by enzymelinked immunosorbent assay.Potential synergistic effects were determined by computing interaction indices from concentration-effect curve parameters.RESULTS:Individual Lingzhi,Kushen and Gancao extracts and ASHMI (the combination of individual extracts) inhibited production of interleukin (IL)-4 and IL-5 by murine memory Th2 cells and eotaxin-1 production by HLF-1 cells.The mean 25%-inhibitory-concentration (IC25)values (mg/mL)forASHMI,Lingzhi,Kushen and Gancaofor IL-4 production were 30.9,79.4,123,and 64.6,respectively; for IL-5 production were 30.2,263,123.2 and 100,respectively;for eotaxin-1 were 13.2,16.2,30.2,and 25.1,respectively.The IC50values (mg/mL) for ASHMI,Lingzhi,Kushen and Gancao for IL-4 production were 158.5,239.9,446.7,and 281.8,respectively; for eotaxin-1 were 38.1,33.1,100,and 158.5,respectively.The interaction indices of ASHMI constituents at IC25 were 0.35 for IL-4,0.21 for IL-5 and 0.59 for eotaxin-1.The interaction indices at IC50 values were 0.50 for IL-4 and 0.62 for eotaxin-1 inhibition.Inhibition of IL-5 did not reach IC50 values.All interaction indices were below 1 which indicated synergy.CONCLUSION:By comparing the interaction index values,we find that constituents in

  11. Studies on Inhibitory Effect of 18 Kinds of Chinese Herbal Medicine on Escherichia coli%18种中草药对大肠杆菌抑菌效果的研究

    Institute of Scientific and Technical Information of China (English)

    赵鑫荟; 艾启俊

    2013-01-01

    [目的]研究鹿蹄草(WINTERGREEN)、功劳叶(CHINESE HOLLY LEAF)、金樱子(CHEROKEE ROSE FRUIT)和大黄(RHEUMOFFICINALE)等18种中草药提取物的抑菌作用.[方法]采用水煎法提取中草药的有效成分,以大肠杆菌作为供试菌,利用滤纸片法测定中草药提取物的抑菌作用,并用2倍稀释法测定抑菌效果最好的4种中草药的最小抑菌浓度.[结果]1s种中草药中有15种对大肠杆菌有抑制作用;其中鹿蹄草的最小抑菌浓度为31.25 mg/ml,功劳叶、金樱子和大黄的最小抑菌浓度均为62.50 mg/ml.[结论]鹿蹄草对大肠杆菌具有较好的抑制效果.%[Objective] The purpose was to investigate the inhibitory effects of 18 kinds of Chinese herbal medicine including WINTERGREEN, CHINESE HOLLY LEAF, CHEROKEE ROSE FRUIT, RHEUM OFFICINALE. [Method] Water decoction method was adopted to extract the active ingredients from Chinese herbal medicine, whose bacteriostatic effect was then determined by filter paper tablet method with Escherichia coli as the indicator bacteria. Double dilution method was used to determine the minimum inhibition concentrations of four kinds of Chinese herbal medicine, whose bacteriostatic effect was best. [ Result] Among the 18 kinds of Chinese herbal medicine, the extracts from 15 kinds of medicine had Inhibitory effect on Escherichia coli. The minimum inhibition concentration of Winlergreen was 31. 25 mg/ml and Chinese holly leaf, Cherokee rose fruit, rheum officinale was all 62.50 mg/ml. [Conclusion] The Wintergreen had a good inhibition effect to Escherichia coli.

  12. Prescription of Chinese Herbal Medicine and Selection of Acupoints in Pattern-Based Traditional Chinese Medicine Treatment for Insomnia: A Systematic Review

    OpenAIRE

    Wing-Fai Yeung; Ka-Fai Chung; Maggie Man-Ki Poon; Fiona Yan-Yee Ho; Shi-Ping Zhang; Zhang-Jin Zhang; Eric Tat-Chi Ziea; Vivian Wong Taam

    2012-01-01

    Traditional Chinese medicine (TCM) treatments are often prescribed based on individuals' pattern diagnoses. A systematic review of Chinese and English literatures on TCM pattern differentiation, treatment principle, and pattern-based treatment for insomnia has therefore been conducted. A total of 227 studies, 17916 subjects, and 87 TCM patterns were analyzed. There was a limited consistency in pattern-based TCM treatment of insomnia across practitioners. Except for Gui Pi Tang, An Shen Ding Z...

  13. Bu-Zhong-Yi-Qi Decoction, the Water Extract of Chinese Traditional Herbal Medicine, Enhances Cisplatin Cytotoxicity in A549/DDP Cells through Induction of Apoptosis and Autophagy

    Science.gov (United States)

    Xiong, Ying

    2017-01-01

    Cisplatin is one of the most active cytotoxic agents for non-small cell lung cancer (NSCLC) treatment. However, the development of cisplatin resistance is common. Bu-Zhong-Yi-Qi decoction (BZYQD), a Chinese traditional herbal medicine, is widely used for the enhancement of antitumor effect in other medications. In this study, we evaluated the effect and drug-resistance reversal mechanism of BZYQD combined with cisplatin on cisplatin-resistant A549/DDP cells. Our results showed that BZYQD exhibited direct cytotoxic and chemosensitizing effects. Cotreatment with BZYQD and cisplatin induced intrinsic apoptotic pathways which were measured by condensed nuclear chromatin, Annexin V/PI apoptosis assay, and apoptosis related proteins expression. In addition, cotreatment with BZYQD and cisplatin also activated autophagy, as indicated by an increase in LC3 puncta, classical autophagosomes and/or autolysosomes, and an accumulation of LC3-II and ATG7 protein. Finally, cotreatment with BZYQD and cisplatin resulted in the generation of ROS and scavenging ROS by NAC almost completely suppressing cell death. These results suggest that cotreatment with BZYQD and cisplatin might reverse cisplatin resistance by inducing ROS accumulation, which activates apoptosis and autophagy by oxidative stress. The combination of BZYQD and cisplatin may represent a novel approach in treatment for NSCLC and thus offer a new target for chemotherapy.

  14. A Standardized Chinese Herbal Decoction, Kai-Xin-San, Restores Decreased Levels of Neurotransmitters and Neurotrophic Factors in the Brain of Chronic Stress-Induced Depressive Rats

    Directory of Open Access Journals (Sweden)

    Kevin Yue Zhu

    2012-01-01

    Full Text Available Kai-xin-san (KXS, a Chinese herbal decoction being prescribed by Sun Simiao in Beiji Qianjin Yaofang about 1400 years ago, contains Ginseng Radix et Rhizoma, Polygalae Radix, Acori tatarinowii Rhizoma, and Poria. KXS has been used to treat stress-related psychiatric disease with the symptoms of depression and forgetfulness in ancient China until today. However, the mechanism of its antidepression action is still unknown. Here, the chronic mild-stress-(CMS- induced depressive rats were applied in exploring the action mechanisms of KXS treatment. Daily intragastric administration of KXS for four weeks significantly alleviated the CMS-induced depressive symptoms displayed by enhanced sucrose consumption. In addition, the expressions of those molecular bio-markers relating to depression in rat brains were altered by the treatment of KXS. These KXS-regulated brain biomarkers included: (i the levels of dopamine, norepinephrine, and serotonin (ii the transcript levels of proteins relating to neurotransmitter metabolism; (iii the transcript levels of neurotrophic factors and their receptors. The results suggested that the anti-depressant-like action of KXS might be mediated by an increase of neurotransmitters and expression of neurotrophic factors and its corresponding receptors in the brain. Thus, KXS could serve as alternative medicine, or health food supplement, for patients suffering from depression.

  15. Add-On Effect of Chinese Herbal Medicine on Mortality in Myocardial Infarction: Systematic Review and Meta-Analysis of Randomized Controlled Trials

    Directory of Open Access Journals (Sweden)

    Vincent C. H. Chung

    2013-01-01

    Full Text Available In China, Chinese herbal medicine (CHM is widely used as an adjunct to biomedicine (BM in treating myocardial infarction (MI. This meta-analysis of RCTs evaluated the efficacy of combined CHM-BM in the treatment of MI, compared to BM alone. Sixty-five RCTs (12,022 patients of moderate quality were identified. 6,036 patients were given CHM plus BM, and 5,986 patients used BM only. Combined results showed clear additional effect of CHM-BM treatment in reducing all-cause mortality (relative risk reduction (RRR = 37%, 95% CI = 28%–45%, I2=0.0% and mortality of cardiac origin (RRR = 39%, 95% CI = 22%–52%, I2=22.8. Benefits remained after random-effect trim and fill adjustment for publication bias (adjusted RRR for all-cause mortality = 29%, 95% CI = 16%–40%; adjusted RRR for cardiac death = 32%, 95% CI = 15%–46%. CHM is also found to be efficacious in lowering the risk of fatal and nonfatal cardiogenic shock, cardiac arrhythmia, myocardial reinfarction, heart failure, angina, and occurrence of total heart events. In conclusion, addition of CHM is very likely to be able to improve survival of MI patients who are already receiving BM. Further confirmatory evaluation via large blinded randomized trials is warranted.

  16. Preventive Effects of the Chinese Herbal Medicine Prescription Tangkuei Decoction for Frigid Extremities on Sciatic Neuropathy in Streptozotocin-Induced Diabetic Rats

    Directory of Open Access Journals (Sweden)

    Pengsong Liu

    2016-01-01

    Full Text Available Ischemia and hypoxia are important physiological changes in diabetic peripheral neuropathy (DPN. Chinese herbal medicine prescription Tangkuei Decoction for Frigid Extremities (TDFE is useful for increasing blood flow. To help determine whether TDFE could protect the peripheral nerves of diabetic patients from the degeneration caused by high blood glucose, TDFE was administered to streptozotocin-induced diabetic rats for 6 or 12 weeks. Plantar thermal stimulation reaction time thresholds, sciatic nerve conduction velocities, and the levels of HIF-1α mRNA, HIF-1α protein, VEGF protein, and the endothelial marker vWF in sciatic nerves were measured at the end of the sixth and twelfth weeks. The thermal thresholds and sciatic nerve conduction velocities of the rats differed after 12 weeks, and the sciatic nerves of the diabetic rats that were given TDFE displayed higher levels of HIF-1α protein, VEGF protein, and HIF-1α mRNA than those of the diabetic model rats. The results at 6 weeks differed from those at 12 weeks. These results suggest that the early preventive application of TDFE effectively delayed the development of DPN and that TDFE increased HIF-1α mRNA levels in the sciatic nerves of diabetic rats through 12 weeks of treatment.

  17. 中草药肝毒性、肾毒性及对策%Hepatotoxicity and Nephrotoxicity of Chinese Herbal Medicine and Their Countermeasures

    Institute of Scientific and Technical Information of China (English)

    焦云涛; 高菁; 任彬; 李雪; 胡杨; 张文; 李靖

    2014-01-01

    This paper makes a summary on hepatotoxicity and nephrotoxicity of Chinese herbal medicine currently and sums up detoxifi -cation measures , such as clearance of the unabsorbed toxic substances , prevention of the absorption of the poison , promotion of excretion of the poison , the rational use of antidote .Meanwhile , we have concluded methods about choosing the appropriate antidote based on the different kinds of drugs at present in order to provide some reference for clinical rational drug use and timely treatment for the poisoning .%对目前有关肝毒性、肾毒性的中草药作一总结,并归纳中毒后的解毒措施:清除未吸收的毒物、阻止毒物的吸收、促进易吸收毒物的排泄及解毒药的合理使用,整理目前针对不同种类药物所选用合适的解毒药,为临床的合理用药及中毒后及时救治提供参考。

  18. A Chinese herbal decoction, reformulated from Kai-Xin-San, relieves the depression-like symptoms in stressed rats and induces neurogenesis in cultured neurons

    Science.gov (United States)

    Yan, Lu; Hu, Qinghua; Mak, Marvin S. H.; Lou, Jianshu; Xu, Sherry L.; Bi, Cathy W. C.; Zhu, Yue; Wang, Huaiyou; Dong, Tina T. X.; Tsim, Karl W. K.

    2016-01-01

    Kai-Xin-San (KXS), a Chinese herbal decoction for anti-depression, is a combination of paired-herbs, i.e. Ginseng Radix et Rhizoma (GR)-Polygalae Radix (PR) and Acori Tatarinowii Rhizoma (ATR)-Poria (PO). The make-up of the paired-herbs has been commonly revised according to syndrome differentiation and treatment variation of individual. Currently, an optimized KXS (KXS2012) was prepared by functional screening different combination of GR-PR and ATR-PO. The aim of this study was to verify the effect and underlying mechanism of KXS2012 against depression in chronic mild stress (CMS)-induced depressive rats and in primary cultures of neurons and astrocytes. In rat model, the CMS-induced depressive symptoms were markedly alleviated by the treatment with KXS2012. The CMS-suppressed neurotransmitter amounts were restored in the presence of KXS2012. And the expressions of neurotropic factors and its corresponding receptors were increased under KXS2012 administration. In cultured neurons, application of KXS2012 could promote neurogenesis by inducing the expression of synaptotagmin and dendritic spine density. Moreover, application of KXS2012 in cultured astrocytes, or in H2O2-stressed astrocytes, induced the expressions of neurotrophic factors: the increase might be associated with the modification of Erk1/2 and CREB phosphorylation. Our current results fully support the therapeutic efficacy of KXS2012 against depression in cell and animal models. PMID:27444820

  19. Effects of Danggui Buxue Tang, a traditional Chinese herbal decoction, on high glucose-induced proliferation and expression of extracellular matrix proteins in glomerular mesangial cells.

    Science.gov (United States)

    Ke, Hao-Liang; Zhang, Ying-Wen; Zhou, Bi-Fa; Zhen, Rui-Tang

    2012-01-01

    Diabetic nephropathy (DN) is the leading cause of end-stage failure of the kidney, but the efficacy of currently available strategies for the prevention of DN remains unsatisfactory. In this study, we investigated the effects of Danggui Buxue Tang (DBT), a Chinese herbal decoction prepared from Radix Astragali (RA) and Radix Angelicae sinensis (RAS), on high glucose-induced proliferation and expression of laminin, type IV collagen (collagen IV) and fibronectin in glomerular mesangial cells (GMCs). The cell proliferation was determined by MTT assay, and the expression of collagen IV, laminin and fibronectin in GMCs was detected by ELISA assay. It was shown that high glucose clearly induced the proliferation of GMCs and increased the release of collagen IV, laminin and fibronectin. Treatment with RA, RAS and DBT inhibited cell proliferation and the expression of collagen IV, laminin and fibronectin induced by high glucose, with DBT, especially at the highest concentration (DBT20), exhibiting a stronger effect than RA and RAS alone. Thus, it is concluded that DBT inhibits increased cell proliferation and the expression of major extracellular matrix proteins that are induced by high glucose, indicating its value for prophylaxis and therapy of DN at the early stages.

  20. 中草药营养去屑洗发香波的研制%Study on shampoo with nutrition and dandruff containing chinese herbal medicine

    Institute of Scientific and Technical Information of China (English)

    喻育红; 周进; 张玲

    2012-01-01

    The active components of Ganoderma lucidum and StepHania tetrandra.S.Moore, triterpenoids and tetrandrine, were extracted by microwave method and then were added into Shampoo. The influence of material dosage and experiment conditions on shampoo with nutrition and dandruff was investigated. The resulted shampoo containing Chinese herbal medicine in this paper was tested according to the trade criterion GB/T11432-89. It can be used safely and there is no stimulation on the skin. The performance of and-dandruff and relieving itching, nourishing and moisten hair, and decontamination was excellent.%选取中草药灵芝和汉防己,采用微波法提取其中的有效成份灵芝三萜和汉防已碱,并将其加入到洗发香波中,考察了原料用量与实验条件对中草药营养去屑洗发香波的影响.实验研制的中草药洗发香波其各项指标均符合国家标准洗发液GB/T11432-89的标准,使用安全,无刺激,有优良的去屑止痒、营养滋润和去污效果.

  1. Determination of Total Germanium in Chinese Herbal Remedies by Square-Wave Catalytic Adsorptive Cathodic Stripping Voltammetry at an Improved Bismuth Film Electrode

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    Shangwei Zhong

    2013-01-01

    Full Text Available A catalytic adsorptive cathodic stripping voltammetric method on an improved bismuth film electrode (BiFE for the determination of trace germanium in the presence of pyrogallol has been investigated. A well-defined and sensitive stripping peak of Ge(IV-pyrogallol complex was observed at −0.79 V (versus SCE in a 0.1 M acetate buffer solution (pH 4.8 at a deposition potential of −0.34 V. The reduction current is catalytically enhanced by adding KBrO3. The experimental variables and potential interference were studied. Compared with the BiFE plated in the solution prepared based on HAc-NaAc without trisodium citrate, the improved BiFE electrodeposited in the solution of HAc-NaAc containing trisodium citrate displayed a better electroanalytical performance for the determination of germanium(IV. Under the optimized conditions, the detection limit of Ge(IV was 60 ng L−1, and the relative standard deviation (RSD was 3.73% at 5 μg L−1 level (n=9. This method was successfully applied to determine the total germanium in several Chinese herbal remedies.

  2. The Prescription Pattern of Chinese Herbal Products Containing Ginseng among Tamoxifen-Treated Female Breast Cancer Survivors in Taiwan: A Population-Based Study

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    Wei-Lung Hsu

    2015-01-01

    Full Text Available Background. The purpose of our study is to analyze the association between prescribed Chinese herbal products (CHPs containing Ginseng and the risk of endometrial cancer among tamoxifen (TMX users and to identify any possible interactive effects between Ginseng and TMX with respect to preventing the development of subsequent endometrial cancer in an estrogen-dependent breast cancer population in Taiwan. Methods. All patients newly diagnosed with invasive breast cancer receiving tamoxifen treatment from January 1, 1998, to December 31, 2008, were selected from the National Health Insurance Research Database. The usage, frequency of service, and CHP-Ginseng prescribed across the 30,556 TMX-treated breast cancer (BC survivors were evaluated. Logistic regression was employed to estimate the odds ratios (ORs for the utilization of CHP-Ginseng. Cox’s proportional hazard regression was performed to calculate the hazard ratios (HRs for endometrial cancer associated with Ginseng use among the TMX-treated BC cohort. Results. The HR for the development of endometrial cancer among breast cancer survivors who had ever taken Ginseng after TXM treatment was significantly decreased compared to those who never used CHP. Conclusion. A significant inhibitory relationship between Ginseng consumption and subsequent endometrial cancer less than 2 years after TMX treatment was detected among BC survivors.

  3. 中草药和益生素对肉仔鸡生产性能影响的研究%The Application Research of Production Performance Effect of Chinese Herbal Medicine and Probiotics on Broilers

    Institute of Scientific and Technical Information of China (English)

    孙根成; 赵德明

    2012-01-01

    试验旨在研究中草药、益生素及其合剂对肉仔鸡生产性能的影响.选择3500只1日龄罗斯308肉仔鸡随机分为7组,每组设5个重复,每个重复100只鸡,对照组饲喂基础日粮,试验1、2、3、4、5组分别在基础日粮的基础上添加0.5%的药方1、药方2、益生素、中草药益生素合剂药方3、中草药益生素合剂药方4组;抗生素组为基础日粮中添加500 mg/kg杆菌肽锌.结果表明,中草药益生素合剂药方3组的体重、料重比、死淘率与对照组相比差异显著(P<0.05),与抗生素组相比差异不显著(P>0.05),优于其它处理组.因此,药方3促生长抗病效果较好,可以替代抗生素.%In order to explore the effect of Chinese herbal medicine, probiotics and its mixture on broiler production traits, the writer divided 3500 chickens into 7 groups randomly, including the blank control group, where broilers were fed on basic feedstuff, the antibiotics control group, where broilers were fed on basic feedstuff and 500 mg/kg bacitracin zinc,the Chinese herbal medicine group 1, the Chinese herbal medicine group 2, the probiotics group, the Chinese herbal medicine and probiotics mixture group 3, the Chinese herbal medicine and probiotics mixture group 4. All the five groups were fed on additional 0.5% their own variations and basic feedstuff. There were five repeats in each group. The results were as follows i compared with the control group, the Chinese herbal medicine and probiotics mixture group 3 had significant differences at the body weight, the feed conversion and the mortality elimination rate of broilers . However, there was no significant difference between group 3 and the antibiotics control group, but its effect was better than any other treatment group. The results indicated the Chinese herbal medicine and probiotics mixture group 3 had better effect on disease-resistant performance and growth promotion, thus, it could be used as a substitute for

  4. Coprescription of Chinese Herbal Medicine and Western Medications among Prostate Cancer Patients: A Population-Based Study in Taiwan

    Directory of Open Access Journals (Sweden)

    Yi-Hsien Lin

    2012-01-01

    Full Text Available Use of herbal medicine is popular among cancer patients. This study aimed to explore the coprescription of CHM and WM among prostate cancer patients in Taiwan. This cross-sectional retrospective study used a population-based database containing one million beneficiaries of National Health Insurance. Claims and prescriptions were analyzed. In 2007, 218 (22.4% prostate cancer patients were CHM users. Among CHM users, 200 (91.7% patients with 5618 (79.5% CHM prescriptions were on coprescription of CHM and WM. A total of 484 types of CHM and 930 types of WM were used. The most commonly used CHMs on coprescription were Shu Jing Huo Xue Tang, Ma Zi Ren Wan, and Xue Fu Zhu Yu Tang. The most commonly used WMs on coprescription were magnesium oxide, amlodipine, and aspirin. The average number of prescriptions per user per year was 261.2 versus 151.7 in all (P<0.001, 123.6 versus 76.9 in WM (P=0.033, and 34.8 versus 5.1 in CHM (P<0.001 for patients with and without coprescription, respectively. In conclusion, use of CHM among prostate cancer patients was popular in Taiwan. Most CHMs were used with WM concurrently. The potential drug-herb interactions should be investigated, especially for patients with more prescriptions.

  5. Exploratory Clinical Trial to Evaluate the Efficacy of a Topical Traditional Chinese Herbal Medicine in Psoriasis Vulgaris

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    Yuhe Yan

    2015-01-01

    Full Text Available Objective. To evaluate the efficacy and safety of herbal ointment, Shi Du Ruan Gao, in patients with plaque-type psoriasis. Design. Single-center, randomized, investigator-blinded, parallel group, placebo-controlled study. Participants. One hundred outpatients with mild to moderate chronic plaque-type psoriasis were enrolled. Intervention. The patients applied either Shi Du Ruan Gao ointment or vehicle ointment topically to for 8 weeks. Main Outcome Measures. The outcomes were assessed using the following criteria: Total Severity Score (TSS, sum of erythema, scaling, and plaque elevation/induration, on a 0 to 4 scale, Investigator Global Assessment (IGA evaluated on a 0 (Clear to 4 (s to very severe scale, and Global Subjects’ Assessment of treatment response on a 7-point scale from −1 (worse to 5 (Cleared. Results. Significant reductions in the Total Severity Score (P<0.001 (mean score: 2.7 after Shi Du Ruan Gao treatment versus 5.1 in control subjects. Both Investigator Global Assessment (IGA and Global Subjects’ Assessment of treatment are better in the Shi Du Ruan Gao group than the control group (P<0.001. Conclusion. Shi Du Ruan Gao ointment was a safe, and effective therapy for plaque-type psoriasis.

  6. Attenuation of Diabetic Nephropathy in Otsuka Long-Evans Tokushima Fatty (OLETF Rats with a Combination of Chinese Herbs (Tangshen Formula

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    Haojun Zhang

    2011-01-01

    Full Text Available Diabetic nephropathy is one of the most significant microvascular complications in patients with type 2 diabetics. The concise mechanism of diabetic nephropathy is unknown and there is no successful treatment. The objective of study was to investigate effects of Chinese herbs (Tangshen Formula on diabetic nephropathy in Otsuka Long-Evans Tokushima Fatty (OLETF rats. OLETF rats and LETO rats were divided into four groups: LETO control, OLETF diabetics, OLETF diabetics treated with Tangshen Formula, and OLETF diabetics treated with Monopril. Body weight, blood glucose, and 24 h urinary proteins were measured once every four weeks. Blood samples and kidney tissues were obtained for analyses of total cholesterol, triglyceride, whole blood viscosity, plasma viscosity, and pathohistological examination at 36 and 56 weeksrespectively. Untreated OLETF rats displayed diabetic nephropathy over the study period. Treatment of OLETF rats with Tangshen Formula attenuated the increases in blood glucose, body weight, 24 h urinary protein content, serum total cholesterol, whole blood viscosity and plasma viscosity at certain time. Treatment with Tangshen Formula also reduced glomerulosclerotic index and interstitial fibrotic index seen in OLETF rats. In conclusion, Tangshen Formula could attenuate the development of diabetic nephropathy in OLETF rat diabetic model.

  7. A theoretical and experimental study on the Fuzzy evaluation model of biological performance of Chinese materia medica with an either cold or hot herbal property%中药寒热药性表达模糊评价模式的理论与实验研究

    Institute of Scientific and Technical Information of China (English)

    金锐; 张冰; 刘小青; 薛春苗; 张倩; 李连珍; 赵茜; 李康

    2012-01-01

    OBJECTIVE: The concepts of cold and hot herbal properties in traditional Chinese medicine (TCM), reflecting the efficacy trends of medicinal herbs, have the Fuzzy characteristics. It is suited for the application of Fuzzy mathematics in research of herbal properties. For a comprehensive evaluation of herbal properties, this work constructed and made a practice of the Fuzzy discrimination model regarding the biological performance of Chinese materia medica.METHODS: Firstly, TCM formulas of cold or hot property were employed for setting the reference values and calculating the membership functions of cold and hot Fuzzy sets with Fisher discriminant. Then the model parameters of cold performance function (CPF) and hot performance function (HPF) were acquired. Second, the experimental data from studies on changes in multisystem indicators of animals given the classical cold formula (Sanhuang Fang) and hot formula (Jiangfugui Fang) were collected to calculate CPF and HPF. Then an experiment of administration of hot property herbs, Rougui (Cortex Cinnamomi) and Xianmao (Rhizoma Curculiginis), and cold property herbs, Huangbai (Cortex Phellodendri) and Zhizi (Fructus Gardeniae) to normal animals and animals with glucocorticoid-induced yang-deficiency or yin-deficiency state was designed. The relative changes in animal states were analyzed by the evaluation model to find the way in which herbal properties are represented.RESULTS: The HPF values of biological performance were higher than the CPF values in administration of Rougui to animals of normal (0. 528>0. 221), yang-deficiency (0. 203> -0. 490) and yin-deficiency (1.750 > -0.479) states, and in administration of Xianmao to animals of normal (0. 474> - 1. 601) and yang-deficiency (0. 288 > -1. 923) states, which represented the hot property. The HPF values of biological performance were lower than the CPF values in administration of Huangbai to animals of normal ( - 0. 870< 0.798) and yang-deficiency ( - 0.339<0. 194

  8. 施氏鲟抗氧化中草药方剂的筛选%Screening of the Antioxidant Chinese Herbal Medicines for Amur Sturgeon (Acipenser schrencki Brandt)

    Institute of Scientific and Technical Information of China (English)

    王荻; 刘红柏; 廉超; 罗添允

    2016-01-01

    In order to screen antioxidant Chinese herbal medicines for the culture of Amur sturgeon ( Aci⁃penser schrenckii Brandt) ,Angelica sinensis,Houttuynia cordata and a kind of Chinese herbal compound ( Pre⁃scription I,PI) was decocted with water and then orally given to the experimental fish of 1+age at the tempera⁃ture of 22 ℃. The activities of antioxidant related enzymes and the content of active substrates in tissues were detected after drug administration.Two parallels were set up in the experimental group,with 30 fish in each one. Angelica sinensis,Houttuynia cordata and PI were orally given to fish at a concentration of 0.3 g/kg,0.54 g/kg and 0.8 g/kg,separately once per day with a continuous administration of 14 d.The distilled water was given to fish as the control group. After the withdrawal of 24 h,half of fish in each group were thermal stimulated at 30 ℃ for 2 h and then the blood and liver were sampled together with the experimental groups at 22 ℃. The activities of SOD,NOS and the contents of MDA,NO in blood and liver were determined. The results showed that 3 kinds of Chinese herbal medicines could affect the activities and contents of antioxidant related sub⁃strates in blood and liver of fish. Angelica sinensis and PI were especially useful to increase SOD activity and decrease MDA content in fish. They also had certain regulation function on NO content and NOS activity and could still keep their utilities at high temperature,which could be used as the antioxidant preparations of Chi⁃nese herbal medicines but need further screening and optimization. Besides, Angelica sinensis is rich in re⁃sources,of low price and easy to use,which therefore has a good application prospect and advantage.%采用口灌方法研究了22℃养殖条件下,当归、鱼腥草及一种自组中草药复方(方一)的水煎剂对1+龄施氏鲟组织中抗氧化功能相关的酶活性及活性物质含量的影响。每受试组设两个平行,

  9. Efficacy and safety of Chinese herbal medicine for chronic prostatitis associated with damp-heat and blood-stasis syndromes: a meta-analysis and literature review

    Directory of Open Access Journals (Sweden)

    Wang Z

    2016-09-01

    Full Text Available Zhiqiang Wang,1 Lei Yuan,1 Yongchuan Wang,2 Baizhi Yang,1 Xiaohong Dong,1 Zhaowang Gao3 1Department of Urology, Shouguang Hospital of Traditional Chinese Medicine, Shouguang, 2Department of Urology, Weifang Traditional Chinese Hospital, Weifang, 3Department of Urology, Shandong University of Traditional Chinese Medicine Affiliated Hospital, Shandong, People’s Republic of China Objective: The aim of this meta-analysis and systematic review is to evaluate the safety and efficacy of Chinese herbal medicine (CHM for chronic prostatitis (CP associated with damp-heat and blood-stasis syndromes.Methods: An electronic search of 13 databases up to May 2016 was screened to identify randomized controlled trials comparing the safety and efficacy of CHM for the treatment of CP associated with damp-heat and blood-stasis syndromes. Studies reporting on effective rates, adverse events, National Institutes of Health chronic prostatitis symptom index (NIH-CPSI scores, and symptom index of Chinese medicine for chronic prostatitis (SI-CM scores as outcomes were included in the analysis. Data were analyzed by fixed- or random-effect models using the Review Manager software.Results: Thirteen articles with the modified Jadad score ≥4 were identified. It was found that CHM was superior to placebo in increasing the efficacy (odds ratio: 6.72, 95% confidence interval [CI]: 2.78–9.48, P<0.00001 and reducing the SI-CM scores (standardized mean difference: -1.08, 95% CI: -1.35 to -0.81, P<0.00001. Oral CHMs were significantly more effective than placebo at reducing NIH-CPSI scores, with a mean difference of -1.39 (95% CI: -1.87 to -0.92, P<0.00001. Nevertheless, no significant differences were found between Prostant and placebo (standardized mean difference: -0.23, 95% CI: -0.46 to 0.01, P=0.06. The frequency of adverse events associated with oral CHM was similar to that associated with placebo (risk ratio: 1.36, 95% CI: 0.72–2.55, P=0.34 and less than that

  10. 深根茎中药材收获机夹持带转速自动控制系统%Automatic Control System in the Gripping-belt Velocity of Root Chinese Traditional Herbal Harvesting Machine

    Institute of Scientific and Technical Information of China (English)

    黄金侠; 王俊发; 于泳红; 李丽敏

    2013-01-01

      我国现有的深根茎中药材收获机械简易,工作效率低,作业质量差,成为中药材种植业发展的一个瓶颈。为此,以AT89 C52单片机为控制核心,以开关传感器为检测手段,结合自动控制原理设计了深根茎中药材收获机夹持带转速自动调节系统。该系统能使夹持带转速实时跟踪机器作业速度变化,从而大大提高了药材的收获效率,降低了药材损失率和破损率。室内土槽试验表明,此控制系统达到了预期设计要求。%Chinese herbal medicine harvester in agricultural production plays an increasingly important role in .However , our Chinese herbal medicine harvester is still poor work quality , low efficiency , fault etc .Good performance , automa-tion, high intelligent degree of the Chinese herbal medicine harvester will be the aspect of development in the future . Therefore , this paper takes the SCM as core , combined with automatic control theory to the design of the traditional Chi-nese medicine harvesting machine clamping belt automatic speed control system .The system according to the operation of the machine speed changes , regulation of harvesting machine clamping belt speed , the machine speed and grip tape speed to achieve the best match , thus greatly improving the performance of the harvesting machine .

  11. The prescription pattern of Chinese herbal products that contain dang-qui and risk of endometrial cancer among tamoxifen-treated female breast cancer survivors in Taiwan: a population-based study.

    Directory of Open Access Journals (Sweden)

    Chien-Tung Wu

    Full Text Available PURPOSE: The increased practice of traditional Chinese medicine worldwide has raised concerns regarding herb-drug interactions. We analyzed the usage of Chinese herbal products containing dang-qui and investigated whether dang-qui therapy increases endometrial cancer risk among tamoxifen-treated breast cancer survivors in Taiwan. METHODS: All patients newly diagnosed with invasive breast cancer who received tamoxifen treatment from January 1, 1998, to December 31, 2008 were selected from the National Health Insurance Research Database. The usage, frequency of service and type of Chinese herbal products containing dang-qui prescribed across the 31,970 survivors were evaluated. Logistic regression method was employed to estimate the odds ratios for utilization of Chinese herbal products containing dang-qui. Cox proportional hazard regression was performed to calculate the hazard ratio of endometrial cancer associated with dang-qui use within the cohort. RESULTS: Almost one in two study subjects had used dang-qui. Among 31,938 tamoxifen-treated breast cancer survivors, 157 cases of subsequent endometrial cancer were identified. The hazard ratio for development of endometrial cancer among breast cancer survivors aged 20-79 years who had taken dang-qui after tamoxifen treatment was decreased compared to survivors who had never used dang-qui (HR: 0.61, 95%CI: 0.44-0.84. To minimise potential confounding factors, women with breast cancer in the reproductive age were excluded from further analysis, and the negative relationship between dang-qui consumption and subsequent endometrial cancer among breast cancer survivors aged 55-79 years was still observed, although not significantly (HR: 0.74, 95%CI: 0.46-1.17. CONCLUSIONS: Dang-qui consumption is common among breast cancer survivors aged 20-79 years and seems decrease the risk of subsequent endometrial cancer after less than a cumulative dose of 7,500 mg of tamoxifen treatment.

  12. Research progress on current pharmacokinetic evaluation of Chinese herbal medicines%中草药新药多成分药代动力学评价的研究进展

    Institute of Scientific and Technical Information of China (English)

    黎国富; 赵浩如; 杨劲

    2011-01-01

    植物药在国外上市前必须经历药代动力学、生物利用度等一系列严格的科学研究以确证其安全性和有效性.美国FDA颁布了(植物药指导原则)以辅助申请者开发植物药,这对中草药新药研发也有极其重要的借鉴意义.该文对与FDA理念相一致的中草药药代动力学评价方法进行了综述和讨论,主要包括中草药中"药代动力学标记物"(PK markers)的鉴定、矩量法整合的多组分药代动力学研究、生物药剂学药物处置分类系统、群体药代动力学--药效动力学在中药-化药相互作用中的研究.%In order to prove safety and efficacy, herbal medicines must undergo the rigorous scientific researches such as pharmacokinetic and bioavailability, before they are put on the market in the foreign countries.Botanical Drug Products promulgated by the US FDA could guide industry sponsors to develop herbal drugs, which was also an important reference for investigating Chinese herbal medicines.This paper reviews and discusses novel approaches for how to assess systemic exposure and pharmacokinetic of Chinese herbal medicines, which were in line with FDA guidance.This mainly focus on identifying pharmacokinetic markets of botanical products, integral pharmacokinetic study of multiple components, Biopharmaceutics drug disposition classification system, and population pharmacokinetic-pharmacodynamic study in herb-drug interaction.

  13. Chinese Herbal Medicine (Weijing Decoction Combined with Pharmacotherapy for the Treatment of Acute Exacerbations of Chronic Obstructive Pulmonary Disease

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    Shaonan Liu

    2014-01-01

    Full Text Available Objective. To evaluate the efficacy and safety of Weijing decoction combined with routine pharmacotherapy (RP for the treatment of acute exacerbations of chronic obstructive pulmonary disease (AECOPD. Methods. Randomized controlled trials (RCT evaluating Weijing decoction for AECOPD were included. English, Chinese, and Japanese databases were searched from their respective inceptions to June 2013. The methodological quality was assessed according to the Cochrane Collaboration’s risk of bias tool. All data were analyzed and synthesized using RevMan 5.2 software. Results. Fifteen (15 studies involving 986 participants were included. Participants were diagnosed with COPD in the acute exacerbation stage. In addition, most of studies reported that they included participants with the Chinese medicine syndrome, phlegm-heat obstructing the Lung. Weijing decoction combined with RP improved lung function (forced expiratory volume in one second; FEV1, arterial blood gases (PaO2 and PaCO2, clinical effective rate, and reduced inflammatory biomarkers (TNF-α and IL-8 when compared with RP alone. No severe adverse events were reported in these studies. Conclusions. Weijing decoction appeared to be beneficial for AECOPD and well-tolerated when taken concurrently with RP, such as antibiotics, bronchodilators (oral and inhaled, and mucolytics.

  14. Epigenetic regulation of active Chinese herbal components for cancer prevention and treatment: A follow-up review.

    Science.gov (United States)

    Huang, Zhiying; Huang, Qiuju; Ji, Liyan; Wang, Ying; Qi, Xiaoxiao; Liu, Liang; Liu, Zhongqiu; Lu, Linlin

    2016-12-01

    Epigenetic modifications include DNA methylation, histone modification, and other patterns. These processes are associated with carcinogenesis and cancer progression. Thus, epigenetic modification-related enzymes, such as DNA methyltransferases (DNMTs), histone methyltransferases (HMTs), histone demethylases (HDMTs), histone acetyltransferases (HATs), and histone deacetylases (HDACs), as well as some related proteins, including methyl-CpG binding proteins (MBPs) and DNMT1-associated protein (DMAP 1), are considered as potential targets for cancer prevention and therapy. Numerous natural compounds, mainly derived from Chinese herbs and chemically ranging from polyphenols and flavonoids to mineral salts, inhibit the growth and development of various cancers by targeting multiple genetic and epigenetic alterations. This review summarizes the epigenetic mechanisms by which active compounds from Chinese herbs exert their anti-cancer effect. A subset of these compounds, such as curcumin and resveratrol, affect multiple epigenetic processes, including DNMT inhibition, HDAC inactivation, MBP suppression, HAT activation, and microRNA modulation. Other compounds also regulate epigenetic modification processes, but the underlying mechanisms and clear targets remain unknown. Accordingly, further studies are required.

  15. Illustration of compositional variations over time of Chinese porcelain glazes combining micro-X-ray Fluorescence spectrometry, multivariate data analysis and Seger formulas

    Energy Technology Data Exchange (ETDEWEB)

    Van Pevenage, J., E-mail: Raman@UGent.be [Department of Analytical Chemistry, Raman Spectroscopy Research Group, Ghent University, Krijgslaan 281, S12, B-9000 Ghent (Belgium); Verhaeven, E. [Department of Conservation and Restoration, University College Antwerp, Blindestraat 9, B-2000 Antwerp (Belgium); Vekemans, B. [Department of Analytical Chemistry, Ghent University, Krijgslaan 281, S12, B-9000 Ghent (Belgium); Lauwers, D., E-mail: Raman@UGent.be [Department of Analytical Chemistry, Raman Spectroscopy Research Group, Ghent University, Krijgslaan 281, S12, B-9000 Ghent (Belgium); Herremans, D.; De Clercq, W. [Department of Archaeology, Ghent University, Sint-Pietersnieuwstraat 35, B-9000 Ghent (Belgium); Vincze, L. [Department of Analytical Chemistry, Ghent University, Krijgslaan 281, S12, B-9000 Ghent (Belgium); Moens, L., E-mail: Raman@UGent.be [Department of Analytical Chemistry, Raman Spectroscopy Research Group, Ghent University, Krijgslaan 281, S12, B-9000 Ghent (Belgium); Vandenabeele, P. [Department of Archaeology, Ghent University, Sint-Pietersnieuwstraat 35, B-9000 Ghent (Belgium)

    2015-01-01

    In this research, the transparent glaze layers of Chinese porcelain samples were investigated. Depending on the production period, these samples can be divided into two groups: the samples of group A dating from the Kangxi period (1661–1722), and the samples of group B produced under emperor Qianlong (1735–1795). Due to the specific sample preparation method and the small spot size of the X-ray beam, investigation of the transparent glaze layers is enabled. Despite the many existing research papers about glaze investigations of ceramics and/or porcelain ware, this research reveals new insights into the glaze composition and structure of Chinese porcelain samples. In this paper it is demonstrated, using micro-X-ray Fluorescence (μ-XRF) spectrometry, multivariate data analysis and statistical analysis (Hotelling's T-Square test) that the transparent glaze layers of the samples of groups A and B are significantly different (95% confidence level). Calculation of the Seger formulas, enabled classification of the glazes. Combining all the information, the difference in composition of the Chinese porcelain glazes of the Kangxi period and the Qianlong period can be demonstrated. - Highlights: • Fully described methodology for the analysis of silicate glazes of Chinese porcelain samples • The combination of a semi-quantitative analysis of silicate glazes, multi-variate data and statistical analysis. • The use of Seger formula to understand better the composition of the glazes. • New insights into the glaze composition and structure of Chinese porcelain glazes of different time periods.

  16. The Effects of One Chinese Herbal Medicine on Fracture Healing of Rabbits%一剂复方中药对家兔骨骼愈合的影响

    Institute of Scientific and Technical Information of China (English)

    曲伟杰; 李进军; 王生奎

    2011-01-01

    The pathways of Chinese herbal medicine in fracture healing are not very well understood. Therefore, the objective of the present study was to evaluate the effects of one compound Chinese herbal medicine on rabbits radius fracture healing using indexes(such as the serum Ca. P, serum ALP, and X-ray of bone fracture). 48 healthy mature rabbits were selected to build standard defect models, and randomly divided into experimental groups and control groups. The control rabbits were given standard diet. Experimental rabbits were fed with standard diet plus Chinese herbal medicine (2. 5 g/kg) every day. The detection was performed on the 2,4,6 and 8 weeks after operation. The results of the study showed that the level of serum Ca, P, the activity of AKP and X-ray appearances for taking Chinese herbal medicine after fracture were significantly higher than that of the control. In conclusion, composite Chinese herbs might shorten the time to union, improve the quality of fracture healing and be beneficial to the fracture healing.%复方中药对骨折愈合的作用机制目前尚不明确,本试验通过观察复方中药对家兔桡骨骨折后血清钙、磷、碱性磷酸酶和X线影像学等指标的影响,分析该中药促骨愈合的效能及其可能作用机理.试验选用48只成年家兔,制成骨缺损标准模型,随机分为试验组和空白对照组,试验组每日在饲料中添加复方中药2.5 g/kg饲喂,对照组给予普通饲料.分别于术后2、4、6、8周进行生化指标和X线影像学检测.试验结果表明,试验组血清钙、血清磷、血清碱性磷酸酶及X线片评分骨折后明显高于对照组.该复方中药能缩短骨折愈合过程所需时间,提高骨折愈合质量,有利于骨折愈合.

  17. Metabonomics Combined with UPLC-MS Chemical Profile for Discovery of Antidepressant Ingredients of a Traditional Chinese Medicines Formula, Chaihu-Shu-Gan-San

    Directory of Open Access Journals (Sweden)

    Hongmei Jia

    2013-01-01

    Full Text Available This study proposed a new strategy for uncovering the active chemical constituents of a traditional Chinese medicines (TCMs formula, Chaihu-Shu-Gan-San (CSGS. Metabonomics and chemical profile were integrated in combination with the multivariate statistical analysis (MVA to discover the chemical constituents which contribute to the antidepressant effect of CSGS. Based upon the difference between CSGS and QZ (CSGS without Zhi-Qiao extracts in the chemical profiles and the regulations of metabolic disturbances induced by CUMS, synephrine, naringin, hesperidin, and neohesperidin were recognized as the active constituents of CSGS from Zhi-qiao responsible for those missing regulations of CSGS when Zhi-Qiao was subtracted from the whole formula. They participated in the regulations of the deviated metabolites 2–4, 10–14, and 22–25, involved in metabolic pathways of ketone bodies synthesis, phenylalanine, tyrosine and tryptophan biosynthesis, valine, aspartate, glutamate metabolism, and glycolysis/gluconeogenesis. Furthermore, the assay of MAO-A activity confirmed the potential antidepressant effect of naringin and its active sites on the MAO-A was inferred by molecular docking study. The integration of metabonomics and chemical profile was proved to be a useful strategy for uncovering what the active chemical constituents in TCM formula are and how they make contributions for the efficacy of the formula.

  18. 骨关节炎的中药治疗现状%Current status of Chinese herbal therapy for osteoarthritis

    Institute of Scientific and Technical Information of China (English)

    曹月龙; 庞坚; 王翔; 石瑛; 沈卫东; 郑昱新; 詹红生; 石印玉

    2006-01-01

    目的:通过证、法、方、药的写作顺序简述中医药治疗骨关节炎的近况.资料来源:应用计算机检索PUBMED 1966-10/2005-10期间的相关文章,检索词为"osteoarthritis,degenerative arthritis,traditional chinese medicine,chinese medieine,chinese botanical medicine,chinese phytotherapy",并限定文章语言种类为English.同时计算机检索万方数据库1979-10/2005-10期间的相关文章,检索词为"骨关节炎,退行性骨关节炎,中医,中国植物药,中国植物药疗法",并限定文章语言种类为中文.资料选择:对资料进行初审,并查看每篇文献后的引文.纳入标准:文章所述内容应与中医药治疗骨关节炎的研究相关.排除标准:重复研究或Meta分析类文章.资料提炼:共收集到284篇相关文献,98篇文献符合纳入标准,排除的186篇文献为内容陈旧或重复.符合纳入标准的98篇文献中,69篇涉及痹证类的病因病机、治法或方药近况,29篇涉及痿类的病因病机、治法或方药近况.本文选用其中的31篇作为资料综合:有学者将骨关节炎归为痹证范畴,相关治法有补肾法;健脾法;祛邪法(包括有祛风除湿法、散寒止痛法、活血祛瘀法、化痰软坚法、解毒散结法).另有学者将骨关节炎归为痿证范畴,治法有养血软坚法、养筋柔肝.大多数文献报道为自拟诊疗标准,缺乏统一公认的疗效评价标准;相对缺少按照循证医学要求进行的前瞻设计的随机、对照临床试验.在用药上,骨关节炎的治疗药物十分广泛,从常用药材至虫毒类药都有.从剂型和药物上对骨关节炎的治疗进行改革和筛选将是中医现代化的有益探索.结论:中医多从痹证或痿证的角度治疗骨关节炎,运用相应的祛邪、补肾、健脾、柔肝药及虫毒类药.目前相对缺少按照循证医学原则要求设计的随机、对照临床试验.

  19. Triptolide, a Chinese herbal extract, protects dopaminergic neurons from inflammation-mediated damage through inhibition of microglial activation.

    Science.gov (United States)

    Li, Feng-Qiao; Lu, Xiu-Zhi; Liang, Xi-Bin; Zhou, Hui-Fang; Xue, Bing; Liu, Xian-Yu; Niu, Dong-Bin; Han, Ji-Sheng; Wang, Xiao-Min

    2004-03-01

    Mounting lines of evidence have suggested that brain inflammation participates in the pathogenesis of Parkinson's disease. Triptolide is one of the major active components of Chinese herb Tripterygium wilfordii Hook F, which possesses potent anti-inflammatory and immunosuppressive properties. We found that triptolide concentration-dependently attenuated the lipopolysaccharide (LPS)-induced decrease in [3H]dopamine uptake and loss of tyrosine hydroxylase-immunoreactive neurons in primary mesencephalic neuron/glia mixed culture. Triptolide also blocked LPS-induced activation of microglia and excessive production of TNFalpha and NO. Our data suggests that triptolide may protect dopaminergic neurons from LPS-induced injury and its efficiency in inhibiting microglia activation may underlie the mechanism.

  20. Orengedoku-to augmentation in cases showing partial response to yokukan-san treatment: a case report and literature review of the evidence for use of these Kampo herbal formulae

    Directory of Open Access Journals (Sweden)

    Okamoto H

    2013-01-01

    Full Text Available Hideki Okamoto,1 Atsushi Chino,1 Yoshiro Hirasaki,1 Keigo Ueda,1 Masaomi Iyo,2 Takao Namiki11Department of Japanese-Oriental (Kampo Medicine, Chiba University Graduate School of Medicine, Chiba City, Japan; 2Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba City, Japan Background: Yokukan-san, a Japanese traditional herbal (Kampo prescription, has recently gathered increasing attention due to accumulating reports showing its remarkable efficacy in treating a wide variety of diseases refractory to conventional medicine as well as the behavioral and psychological symptoms of dementia. As yokukan-san has become broadly integrated with conventional medicine, augmentation therapy with other Kampo prescriptions has become necessary when the yokukan-san has been only partially efficacious. In this paper, we report three cases in which the addition of orengedoku-to, another Kampo formula, to yokukan-san was remarkably effective.Cases: Case 1 was an 85-year-old man with Alzheimer-type dementia who had become aggressive during the past 2 years. Three milligrams of aripiprazole completely suppressed his problematic behaviors but had to be stopped because of extrapyramidal symptoms. In the second case, a 44-year-old man with methamphetamine-induced psychosis had suffered from serious tardive dystonia for 2 years. No conventional approach had improved his tardive dystonia. The third case was a 29-year-old engineer who often failed to resist aggressive impulses and was diagnosed with intermittent explosive disorder. He was prescribed 5 mg of olanzapine, which did not suppress his extraordinary anger and caused somnolence even though the dose was low.Interventions and outcomes: Yokukan-san was complementarily added to the patients' regular medication and exerted a definitive but partial effect in all cases. The addition of orengedoku-to to yokukan-san exerted the same efficacy as aripiprazole in controlling aggressiveness in Case 1

  1. The Functional Study of a Chinese Herbal Compounded Antidepressant Medicine--Jie Yu Chu Fan Capsule on Chronic Unpredictable Mild Stress Mouse Model.

    Directory of Open Access Journals (Sweden)

    Lingling Ding

    Full Text Available Jie Yu Chu Fan capsule (JYCF is a new compounded Chinese herbal medicine for the treatment of depression. The present study was designed to explore the antidepressant effects and the possible mechanisms of JYCF by using chronic unpredictable mild stress (CUMS mouse model and comparing results to that of fluoxetine. Behavioral tests including an open field test, sucrose preference test and forced swim test were performed to evaluate the antidepressant effects of JYCF. The concentrations of monoamine neurotransmitters and metabolic products including norepinephrine (NE, 5-hydroxytryptamine (5-HT, dopamine (DA, 5-hydroxyindoleacetic acid (5-HIAA, homovanillic acid (HVA and 3,4-dihydroxyphenylacetic acid (DOPAC in the cerebral cortex and hippocampus of mice were determined by means of high performance liquid chromatography with electrochemical detection (HPLC-EC. The results show that a successful mouse CUMS model was established through 5 weeks of continuous unpredictable stimulation, as indicated by the significant decrease in sucrose preference and locomotor activity and increase in immobility time in the forced swim test. Chronic treatment of JYCF (1.25, 2.5 and 5 g/kg and fluoxetine (20 mg/kg significantly reversed the CUMS-induced behavioral abnormalities. JYCF (1.25, 2.5 and 5 g/kg significantly increased NE in CUMS mouse prefrontal cortex (P < 0.01, P < 0.01, P < 0.05 respectively and 5-HT in hippocampus (P < 0.05. In summary, our findings suggest that JYCF exerts comparable antidepressant-like effects to that of fluoxetine in CUMS mice. Besides, the antidepressant-like effect of JYCF is mediated by the increase of monoaminergic transmitters including 5-HT and NE.

  2. 使用中药汤剂治疗眩晕应注意的细节%Details on Traditional Chinese Medicinal Herbal Decoction for Vertigo

    Institute of Scientific and Technical Information of China (English)

    吕薇

    2012-01-01

    针对治疗眩晕的中药汤剂的特点,对调剂过程中应注意的细节进行了说明;对煎煮过程中需采用特殊煎法的中药饮片进行了归纳;对服用过程中药引的应用、服药温度及时间、饮食宜忌进行了总结.还对含有毒中药和易产生副作用中药的此类汤剂的服用注意事项及此类中药汤剂与西药同用的禁忌等方面进行了探讨,为临床上能够真正安全、合理、有效地运用中药汤剂治疗眩晕提供参考.%Regarding the characteristic of traditional Chinese medicinal herbal decoctions for vertigo, the details during dispensing were explained.The kinds of decoction pieces which should be decocted specially were summarized. The use of guiding herbs, the time and temperature of taking decoctions as well as the compatibility and incompatibility of diet were instructed. Moreover, the issues, such as the precautions for taking the decoctions containing virose species and paratherapeutic decoction pieces and the incompatibility between decoctions and western medicines were discussed. It aimed to provide the references for safe, reasonable and effective use of decoction for the treatment of vertigo in clinical practice.

  3. Prevention of Canine Distemper in Dog with Chinese Herbal Medicine%中医药对犬瘟热的防制

    Institute of Scientific and Technical Information of China (English)

    胡小九; 李石友; 申时先; 施忠芬; 李秀枝

    2013-01-01

    In order to search a method to protect canine distemper of dog.The study of Chinese herbal medicine started at a cultivation farm in Kunming from April.2009 to Oct.2010,the results showed that all of sick dogs that got canine distemper was about 55.56% and 33.33%. most of them manifested symptoms of double-aspect fever,conjunctivitis,respiratory trachea inflammation,digestion disorder and neural symptom. The causes of why the dogs got this disease were relative to many factors, such as ages, immune status, sexes, environment and the seasons.And it can be used as reference for the prevention and cure of canine distemper.%2009年4月~2010年10月在昆明某养犬场进行中草药配方预防犬的犬瘟热的试验,结果表明,犬在未免疫状况下犬瘟热发病率为55.56%(5/9)和33.33%(3/9).中草药配方防犬瘟2号、3号对犬的犬瘟热疾病以及犬其它疾病有一定的预防作用,分别提高20.83%~33.33%和12.70%~ 18.06%.研究的中草药配方防犬瘟1号也对疫苗预防犬的犬瘟热疾病有较明显的加强效果,可提高33.33%.

  4. A prescribed Chinese herbal medicine improves glucose profile and ameliorates oxidative stress in Goto-Kakisaki rats fed with high fat diet.

    Directory of Open Access Journals (Sweden)

    Lin Wu

    Full Text Available Oxidative stress (OS plays a role in hyperglycemia induced islet β cell dysfunction, however, studies on classic anti-oxidants didn't show positive results in treating diabetes. We previously demonstrated that the prescribed Chinese herbal medicine preparation "Qing Huo Yi Hao" (QHYH improved endothelial function in type 2 diabetic patients. QHYH protected endothelial cells from high glucose-induced damages by scavenging superoxide anion and reducing production of reactive oxygen species. Its active component protected C2C12 myotubes against palmitate-induced oxidative damage and mitochondrial dysfunction. In the present study, we investigated whether QHYH protected islet β cell function exacerbated by high fat diet (HFD in hyperglycemic GK rats. 4-week-old male rats were randomly divided into high HFD feeding group (n = 20 and chow diet feeding group (n = 10. Each gram of HFD contained 4.8 kcal of energy, 52% of which from fat. Rats on HFD were further divided into 2 groups given either QHYH (3 ml/Kg/d or saline through gastric tube. After intervention, serum glucose concentrations were monitored; IPGTTs were performed without anesthesia on 5 fasting rats randomly chosen from each group on week 4 and 16. Serum malondialdehyde (MDA concentrations and activities of serum antioxidant enzymes were measured on week 4 and 16. Islet β cell mass and OS marker staining was done by immunohistochemistry on week 16. QHYH prevented the exacerbation of hyperglycemia in HFD feeding GK rats for 12 weeks. On week 16, it improved the exacerbated glucose tolerance and prevented the further loss of islet β cell mass induced by HFD. QHYH markedly decreased serum MDA concentration, increased serum catalase (CAT and SOD activities on week 4. However, no differences of serum glucose concentration or OS were observed on week 16. We concluded that QHYH decreased hyperglycemia exacerbated by HFD in GK rats by improving β cell function partly via its

  5. Studies on Drying Mathematic Model of Chinese Herbal Medicine and Parameter Analysis by Heat Transfer Theory%基于传热学原理研究中药材干燥数学模型及参数分析

    Institute of Scientific and Technical Information of China (English)

    熊耀坤; 何雁; 黄恺; 杜焰; 冯怡

    2012-01-01

    This study was aimed to establish the drying mathematical model of Chinese herbal medicine. The energy changes and influence factors were studied in the process of Chinese herbal medicine dried by thermodynamic theory. The Chinese herbal medicine drying mathematical model and analysis of the parameters ere established. The results showed that the existing drying research of Chinese herbal medicine is the summary of experienced knowledge. There is a big blindness in the choice of the drying method, process and equipment. We quantized the process of drying, and established Chinese herbal medicine drying mathematical model. The established parameters of the external environment are the heat conduction parameter C, the thermal radiation parameter D, and heat exchange parameters E. These parameters reflect the drying efficiency of the drying equipment. The established parameters of medicinal properties are the porosity Φ, specific heat Cp, herbs surface area S. These parameters reflect the herb drying capacity. It was concluded that the strengthening of basic theory study on Chinese herbal medicine drying will provide new methods and ideas for the reasonable selection of drying methods, processes and equipments. Therefore, the drying efficiency will be improved and the energy consumption will be reduced.%目的:建立中药材干燥数学模型,为优化干燥工艺提供理论依据.方法:运用传热学原理,探求中药材干燥过程中影响因数及能量变化过程,建立中药材干燥数学模型,并对参数进行分析.结果:现有中药材的干燥研究多为经验知识的总结,在干燥方法、工艺及设备的选择上存在很大的盲目性.本文量化了中药材干燥过程,建立起中药材干燥数学模型,建立起干燥条件参数:热传导参数C、热辐射参数D、为热交换参数E,用于评价干燥设备的干燥性能;建立起干燥物性参数:孔隙率椎、比热Cp、药材表面积S等,用于评价药材可干燥能力.

  6. 中草药在正畸牙移动牙周组织改建中的作用%The function of Chinese herbal medicine in the reconstruction of periodontal tissue during orthodontic tooth movement

    Institute of Scientific and Technical Information of China (English)

    陈雅竹; 管晓燕; 肖茜文; 王斯玮; 刘建国

    2014-01-01

    BACKGROUND:Orthodontic tooth movement is based on the periodontal tissue remodeling. In the exogenous factors accelerating orthodontic tooth movement, Chinese herbal medicine has become a research hotspot because of its wide resources, low cost, easy to extract, mild effect, smal toxic, less side effects and drug resistance. OBJECTIVE: To summarize the role of Chinese herbal medicine in the periodontal tissue remodeling during orthodontic tooth movement. METHODS:A computer-based retrieval of CNKI, Wanfang and PubMed databases was performed for articles related to Chinese herbal medicine for improving orthodontic tooth movement published before 2014. The keywords were “Chinese herbal medicine, orthodontic tooth movement, periodontal tissue remodeling” in Chinese and English, respectively. RESULTS AND CONCLUSION:Erigeron breviscapus, Salvia, teasel, Drynaria, baicalin, evening primrose oil as Chinese herbs are most widely used in the promotion of periodontal tissue remodeling, characterized as wide resources, low cost, easy to extract, mild effect, low toxicity, less drug resistance. In the clinical orthodontic treatment, it is hoped to accelerate orthodontic tooth movement and shorten the treatment time. Therefore, under the appropriate corrective force, Chinese herbs can be used properly to improve periodontal tissue repair and remodeling, which can improve the microcirculation of periodontal tissue, increase the local blood flow, promote bone formation and repress bone resorption.%背景:正畸牙移动以牙周组织改建为基础和前提,在加快正畸牙移动的外源性因素中,中草药以其资源广,成本低,易提取,作用温和,毒副作用小,不易产生耐药性等优点成为研究的热点。目的:就中草药在正畸牙移动牙周组织改建中的作用等研究进展作一综述。方法:使用计算机检索中国知网,万方医学网及PubMed数据库从建库起至2014年有关促进正畸

  7. Efficacy and safety of Chinese herbal medicine for chronic prostatitis associated with damp-heat and blood-stasis syndromes: a meta-analysis and literature review

    Science.gov (United States)

    Wang, Zhiqiang; Yuan, Lei; Wang, Yongchuan; Yang, Baizhi; Dong, Xiaohong; Gao, Zhaowang

    2016-01-01

    Objective The aim of this meta-analysis and systematic review is to evaluate the safety and efficacy of Chinese herbal medicine (CHM) for chronic prostatitis (CP) associated with damp-heat and blood-stasis syndromes. Methods An electronic search of 13 databases up to May 2016 was screened to identify randomized controlled trials comparing the safety and efficacy of CHM for the treatment of CP associated with damp-heat and blood-stasis syndromes. Studies reporting on effective rates, adverse events, National Institutes of Health chronic prostatitis symptom index (NIH-CPSI) scores, and symptom index of Chinese medicine for chronic prostatitis (SI-CM) scores as outcomes were included in the analysis. Data were analyzed by fixed- or random-effect models using the Review Manager software. Results Thirteen articles with the modified Jadad score ≥4 were identified. It was found that CHM was superior to placebo in increasing the efficacy (odds ratio: 6.72, 95% confidence interval [CI]: 2.78–9.48, P<0.00001) and reducing the SI-CM scores (standardized mean difference: −1.08, 95% CI: −1.35 to −0.81, P<0.00001). Oral CHMs were significantly more effective than placebo at reducing NIH-CPSI scores, with a mean difference of −1.39 (95% CI: −1.87 to −0.92, P<0.00001). Nevertheless, no significant differences were found between Prostant and placebo (standardized mean difference: −0.23, 95% CI: −0.46 to 0.01, P=0.06). The frequency of adverse events associated with oral CHM was similar to that associated with placebo (risk ratio: 1.36, 95% CI: 0.72–2.55, P=0.34) and less than that associated with Prostant (risk ratio: 1.63, 95% CI: 1.14–2.34, P=0.008). Conclusion Our novel analysis demonstrates that CHM ranks highest in terms of improvement of CP associated with damp-heat and blood-stasis syndromes. While Prostant showed some efficacy in this disorder, it was associated with a smaller reduction in NIH-CPSI scores. In conclusion, CHM monotherapy is safe and

  8. Chinese Herbal Medicine for Improving Quality of Life Among Nonsmall Cell Lung Cancer Patients: Overview of Systematic Reviews and Network Meta-Analysis.

    Science.gov (United States)

    Wu, Xinyin; Chung, Vincent C H; Lu, Ping; Poon, Simon K; Hui, Edwin P; Lau, Alexander Y L; Balneaves, Lynda G; Wong, Samuel Y S; Wu, Justin C Y

    2016-01-01

    For patients with nonsmall cell lung cancer (NSCLC) receiving chemotherapy, current clinical evidence has indicated add-on benefit of Chinese herbal medicine (CHM) in improving quality of life (QoL). However, the relative performance among different CHM is unknown. The aim of this overview of systematic reviews (SRs) and network meta-analyses (NMA) is to evaluate the comparative effectiveness of different CHM. Seven electronic databases including both international databases and Chinese databases were searched. SRs focus on randomized controlled trials (RCTs) with comparison of CHM plus chemotherapy against chemotherapy alone on QoL among NSCLC patients were considered eligible. Data from RCTs were extracted for random effect pairwise meta-analyses. Pooled relative risk (RR) with 95% confidence interval (CI) was used to quantify the impact of CHM on QoL. NMA was used to explore the most effective CHM for improving QoL when used with chemotherapy. From 14 SRs, 61 RCTs (n = 4247) assessing 11 different CHM were included. Result from pairwise meta-analyses showed 6 CHM (Kang-lai-te injection, Shei-qi-fu-zheng injection, Compound ku-shen injection, Kang-ai injection, Zi-jin-long tablet, and Shen-fu injection) has significant beneficial effect on QoL among NSCLC patients when used with chemotherapy, even after adjustment for publication bias. Pooled RR varied from 1.38 (95% CI: 1.11-1.72, I2 = 0.0%, Kang-lai-te injection) to 3.36 (95% CI: 1.30-8.66, I2 = 0.0%, Zi-jin-long tablet). One trial comparing Hai-shen-su (a protein extract from Tegillarca granosa L.) plus chemotherapy with chemotherapy also demonstrated beneficial effect of combined treatment (RR = 3.13, 95% CI: 1.41-6.98). Results from NMA showed no differences on the comparative effectiveness among CHM, but Hai-shen-su plus chemotherapy has the highest probability (62.3%) of being the best option for improving QoL. Use of CHM on top of chemotherapy can significantly improve QoL in NSCLC patients. Although Hai

  9. 中草药结合涂膜用于草莓保鲜的研究%Chinese Herbal Medicine Combined with Coating for the Preservation of Strawberry

    Institute of Scientific and Technical Information of China (English)

    徐放; 赵鹏宇; 吴小虎; 石莹; 艾启俊

    2013-01-01

    [目的]研究中草药结合涂膜保鲜技术对草莓保鲜的效果.[方法]以可食性的壳聚糖、纳米氧化硅,以及甘油、单甘脂等为材料,制出一种可食性的草莓保鲜膜,并将鹿蹄草、黄芩、黄柏、半边莲、北豆根5种中草药的单一或组配制剂中保鲜防腐效果最佳的组配进行前期处理.通过腐败率、感官评价等指标判断其对草莓的保鲜效果.[结果]试验表明,壳聚糖-纳米氧化硅保鲜涂膜与鹿蹄草水煎液能够显著抑制青霉、灰霉的繁殖,该处理对草莓有较好的抑菌保鲜作用,能够使常温下“丰香”草莓的保鲜期达到5d.[结论]研究可为目前市场上草莓的常温保鲜提供参考依据.%[Objective] To study fresh-keeping effect of Chinese herbs combing with coating technology on strawberry. [Method] With edible chitosan, nano silica, glycerol, monoglyceride as materials, a kind of edible strawberry plastic wrap was made. Early treatment was conducted on five kinds of Chinese herbal medicine wintergreen, baicalin, Cortex Phellodendri, lobelia, Rhizoma Menispermi in single or group of formulation of preservation and antisepsis effect. The fresh-keeping effect of strawberry was judged by decay rate, sensory evaluation index. [ Result] The experimental results showed that the chitosan-nano silica preservation coating and wintergreen water extract can inhibit the propagation of Penicillium, gray mold, the processing of strawberry has better antibacterial fresh-keeping effect, can make the room temperature" Toyonoka strawberry" preservation period up to 5 days. [Conclusion] The study can provide reference basis for normal temperature preservation of strawberry.

  10. Kidney-reinforcing Chinese herbal mixture promote the osseointegration of dental implant bone in vivo%补肾中药合剂促进牙种植体骨结合体内试验

    Institute of Scientific and Technical Information of China (English)

    陈国栋; 蔡嘉喜; 黄万仁; 梁淑霞; 胡超; 郭吕华

    2014-01-01

    Objective: Histopathological and Imageological method were used to assess osseointegration of dental implant after kidney-reinforcing chinese herbal mixture. Methods: 12 rabbits were divided into two groups at random, both at the top of the the tibial inserted implant pure titanium implant, a group kidney-reinforcing chinese herbal mixture were added to the feed, another group didn't join any drugs, after 30 days and 60 days put to death, with histopathologic evaluation of osseointegration of dental im-plant and bone tissue morphology metrology method. Results: The results of experimental pathology, bone tissue morphology metrology parameters and radiographic outcomes, were better than control group. Conclusion: Kidney-reinforcing chinese herbal mixture may promote osseointegration of dental implant.%目的:用组织病理学、影像学方法评估补肾中药合剂对牙种植骨结合的效果。方法:12只兔子随机分成二组,均在其胫骨顶端植入纯钛种植体,一组饲料中加入补肾中药合剂,另一组饲料中没加入任何药物,30天、60天后处死免子,分别用组织病理学及影像学方法评估种植体骨结合的情况。结果:试验组的病理学及影像学结果明显优于对照组;结论:补肾中药合剂能促进种植体骨结合。

  11. Screening of QHF formula for effective ingredients from Chinese herbs and its anti-hepatic cell cancer effect in combination with chemotherapy

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Background Recent studies have shown that effective ingredients of Chinese herbs are used more and more widely in the treatment or co-treatment of cancers,however,they are usually used separately and there has been limited research about joint application of Chinese herbs in multi-modal treatment.The aim of this study was to screen a QHF(Q:Qingrejiedu,H:Huoxuehuayu and F:Fuzhengguben)formula for effective ingredients from Chinese medicines and assess its anti-hepatic cell cancer(HCC)effect in combination with chemotherapy.Methods Six effective ingredients from Chinese medicine were selected based on the previous literature and used in the study.The QHF formula and the best ratio of ingredients were evaluated in H22 mouse(KM)models with solid tumors and ascites tumors by uniform design and monitoring inhibition of tumor growth and survival.We then observed the anti-hepatic cell cancer(HCC)effect of QHF when combined with cisplatin(DDP)in H22 mouse(Balb/c)models with solid tumors and ascites tumors.Evaluating of the therapeutic effect included the general condition of the mice,inhibition of tumor growth,survival,changes in body weight,thymus index,spleen index and WBC counts.Results The optimal QHF dose ratio for anti-hepatic cell cancer treatment was:800 mg/kg Cinobufotalin,14 mg/kg Ginsenosides Rg3,5.5 mg/kg PNS and 100 mg/kg Lentinan.Treatment was more efficient in inhibiting the growth of transplanted tumors in H22 mice when using the QHF formula(55.91%)than using Cinobufotalin(33.25%),Ginsenosides Rg3(35.11%),PNS(27.12%)or Lentinan(4.97%)separately.QHF also prolonged the life of H22 ascites hepatic cancer mice more efficiently(38.13%)than Cinobufotalin(25.00%),Ginsenosides Rg3(27.27%),PNS(23.30%) or Lentinan (24.43%).QHF combined with DDP could reduce DDP-induced leucopenia,spleen and thymus atrophy and other toxic reactions.Combining QHF with DDP the tumor growth inhibition reached 82.54% with a 66.83% increase in survival.Conclusions QHF is more efficient in

  12. 安徽省中药材出口贸易现状与发展对策--以亳州药材为例%Chinese Herbal Medicine Export Trade Situation and Development Strategy of Anhui Province:A Case Study of Bozhou Medicine

    Institute of Scientific and Technical Information of China (English)

    侯晶; 王萍; 侯博

    2014-01-01

    本文首先简要介绍了我国中药行业的出口现状,然后以安徽亳州为例,介绍安徽省中药材产业发展及出口情况,最后分析安徽省中药材出口贸易的优劣势,对中药出口存在的问题提出合理化建议。%This paper briefly describes the status of the export of Chinese herbal medicine industry, then by taking Bozhou in Anhui for example, describes the development and export of Chinese herbal medicine industry in Anhui Province, and finally analyzes the advantages and disadvantages of Anhui medicines export trade and proposes rational proposals for the problems of Chinese herbal medicine export.

  13. Four properties law of nature data of Chinese materia medica in "Chinese herbal medicine (CHM)"%《中华本草》药性数据中的四气规律

    Institute of Scientific and Technical Information of China (English)

    杨雪梅; 林端宜; 赖新梅; 陈梅姝; 黄璐琦

    2013-01-01

    目的:以四气为核心,分析中药药性数据中气与味、归经、毒性之间的相关关系,为中医临床用药、中药实验研究、中药新资源开发等提供理论线索和数据支持.方法:在对数据等级编码基础上,采用spearman等级相关法对《中华本草》中8 356味具有四气属性中药的药性规律进行分析.结果:四气与辛、甘2味存在显著正相关(P<0.01);与苦、淡2味存在显著负相关(P<0.01);与脾、胃、肾三经存在显著正相关(P<0.01);与大肠、心、膀胱、胆、小肠、肺六经(按相关性递减排序)存在显著负相关(P<0.01);与毒性之间存在显著正相关(P<0.01).结论:药性越“热”则越可能具有辛、甘2味,越常入脾、胃、肾三经,其毒性更大;药性越“寒”则越可能具有苦、淡2味,越常人大肠等六经.%Objective:In order to provide theoretical clues and data support for the use of Chinese medicine clinical drug,experimental study of Chinese materia medica and development of new resources of Chinese materia medica,the four properties as the core,the relationships of property,flavor,channel tropism and toxicity in nature data of Chinese materia medica were analyzed.Method:The spearman rank correlation method was employed to analyze 8 356 Chinese drugs with characteristic of four properties from "Chinese Herbal Medicine" based on data level coding.Result:It was discovered that four properties showed significant positive correlations with tastes of "pungent and sweet",channels of "spleen","stomach","kidney" and "toxicity",but also showed significant negative correlations with tastes of "bitter" and "hght" and six channels such as "large intestine","heart"," bladder","gallbladder","small intestine" and "lung" (in descending order of correlation) (P <0.01).Conclusion:It was indicated that the more hot the Chinese medicine nature,the more possible it contained "toxicity",tastes of "pungent" and "sweet",and the more

  14. China's Formula,Go!

    Institute of Scientific and Technical Information of China (English)

    Li Yinghong; Yang Wei

    2009-01-01

    @@ On the first day of November,when Jenson Button cheered his first Formula I World Championship 2009 at the final race of the season in Abu Dhabi,Chinese young university students were busy preparing for their own Formula event.According to a press conference on October 19,2009 in Beijing,the first Formula SAE-China (FSAE) event has set off,and will be officially launch its final race next year from October 14 to October 17 at Shanghai International Circuit,where will also be the Formula 12010 China stop again in next April.

  15. Observation of Therapeutic Effects of Two Traditional Chinese Herbal Medicines on Piglet' s Yellow- white Dysentery%两种中成药防治仔猪黄白痢的疗效观察

    Institute of Scientific and Technical Information of China (English)

    邢四仙; 张建乐

    2012-01-01

    采用中成药“母仔安”给分娩前3d、产仔后7~10d的母猪喂服、“仔痢宁”给已产黄白痢仔猪的母猪喂服3~5d,观察其发病率、病死率及双月仔猪成活率。试验结果表明:服用“母仔安”的产仔母猪所产仔猪发病率下降11.56%,病死率下降15.58%,双月成活率提高9.61%,非病死率下降1.1%;服用“仔痢宁”的母猪所产仔猪发病率下降6.9%,治愈率占发病数的88.9%,病死率下降18.93%,双月成活率提高8.72%,非病死率下降1.86%。%Piglet's yellow -white dysentery was an epidemic gastroenteritis caused by the pathogenic Escherichia coli with multiple serotypes in piglets induced by dysentery, high incidence, difficulty in cure, the high mortality. The test of feeding Muzian of traditional Chinese herbal medicine three days before delivery or 7 -10 days after farrowing and feeding Zilining of traditional Chinese herbal medicines for 3 - 5 days to sows was done to observe the incidence, mortality and survival rate of piglets bimonthly. The results showed that the incidence of piglet' s yellow - white dysentery after feeding Muzian of traditional Chinese herbal medicines to farrowing sows was seen down by | 1.56%, case fatality rate decreased by 15.58%, bimonthly survival rate increased by 9.61%, non - fatality rate decreased by 1.1%. The incidence of piglet' s yellow - white dysentery after feeding Zilining of traditional Chinese herbal medicines decreased by 6.9% , the cure rate of incidence number was 88.9% , case fatality rate decreased by 18.93% . bimonthly survival rate increased bv 8.72% , non -fatality rate decreased by 1.86%.

  16. QUALITY CONTROL FOR CHINESE HERBAL DRUGE USING DNA PROBE TECHNOLOGY%DNA探针技术在中药材品质监控方面的研究与应用

    Institute of Scientific and Technical Information of China (English)

    刘玉萍; 曹晖; 小松子; 毕培曦

    2001-01-01

    @@ INTRODUCTION The type and spectrum of diseases are changing significantly as the society aging today. The autoimmune diseases such as senile dementia, AIDS, as well as cardio-cerebral vascular diseases such as hypertension, arrhythmia, myocardiac infarction are becoming an intractable and globular problem. Recently, people are very much concerned with side effects of synthetic pharmaceuticals and are anxious to return to the use of natural medicine. Back to nature, the need for Chinese herbal drugs is increasing gradually for prevention and therapy of diseases in the world.

  17. Efficiency observations of massotherapy associated with Chinese herbal medicine in treating cervical vertigo%推拿中药结合治疗颈性眩晕的疗效观察

    Institute of Scientific and Technical Information of China (English)

    闫红卫; 陈珊珊

    2016-01-01

    Objective: To observe the therapeutic effects of massotherapy associated with Chinese herbal medicine in treating cervical vertigo. Methods: 100 patients with cervical vertigo, who were admitted and treated in our hospital from June 2013 to June 2015, were randomly divided into the experiment group and the control group, with 50 cases in each group. The experiment group received massotherapy associated with Chinese herbal medicine while the control group received only Chinese herbal medicine, the therapeutic effects of two groups were compared. Results: The therapeutic effect of the experiment group was significantly better than that of the control group, the difference was statistically significant. Conclusion: Massotherapy associated with Chinese herbal medicine could significantly improve the blood circulation in the neck and brain of patients with cervical vertigo, which would in turn improve the patients clinical situation, therefore, it was worthy of clinical application and promotion.%目的:探讨推拿中药联合治疗颈性眩晕的临床效果。方法:将本院自2013年6月—2015年6月收治的100例颈性眩晕患者作为研究对象,随机分为实验组和对照组,每组50例。实验组实施推拿联合中药治疗,对照组实施中药治疗。治疗结束后,比较两组患者的治疗效果。结果:实验组患者的治疗效果明显好于对照组患者,且两组患者比较差异具有显著性。结论:推拿中药联合治疗颈性眩晕患者能够改善其颈部和脑部的血液循环,进而改善患者临床状况,值得在临床推广应用。

  18. Advances in Study on Anti-bacterial Infections of Gastrointestinal Tract of Chinese Herbal Medicines%中草药抗胃肠道细菌感染的研究进展

    Institute of Scientific and Technical Information of China (English)

    蔡延渠; 朱盛山; 陈健; 李润萍

    2011-01-01

    Objective:To make a review about the research of Chinese herbal medicines in anti-bacterial infections of gastrointestinal tract, as the meaning of providing reference for clinical use and further research.Method: The monographs and literatures over the past decade in China about anti-bacterial infections of gastrointestinal tract of Chinese herbal medicines, analyze and summary separately from the two major categories of single herb and compound herbs in anti-bacterial infections of gastrointestinal tract.Result: Single and compound Chinese herbal medicines have good effect in anti-bacterial infections of gastrointestinal tract, and also are with the advantages of rich resources, little side effects, low drug resistance and so on.Conclusion: Chinese herbal medicine is another good ‘ antibiotic’ in clinical treatment of anti-bacterial infections of gastrointestinal tract, and has the great significance of development.%目的:综述中草药在抗胃肠道细菌感染方面的研究进展,为临床使用和进一步研究提供参考.方法:检索、查阅国内近10年来有关中草药抗胃肠道细菌感染的研究性文献与著作,并就单味和复方中药对引起胃肠道感染的各属致病菌的抑菌作用进行分析总结.结果:单味和复方中药对常见的致胃肠道感染的各属致病菌具有较强抑菌作用,且具备资源丰富、副反应小、不易产生耐药性等优势.结论:中草药是临床治疗胃肠道细菌感染的另一良好"抗生素",具有重大研发意义.

  19. Effects of Chinese Herbal Medicine Combined with He-Ne Laser on Lipoperoxide and Superoxide Dismutase in Chloasma Patients

    Institute of Scientific and Technical Information of China (English)

    WU Yan-hua; LI Qi-lin; YANG Xiu-wen

    2009-01-01

    Objective:To observe the effects of Chinese decoction and ligustrazin hydrochloride injection combined with He-Ne laser on lipoperoxide (LPO) and Superoxide dismutase (SOD) in patients with chloasma.Methods:90 cases of chloasma were randomly divided into the following two groups:a treatment group (of 54 cases) treated by a self-prepared prescription for toning the kidneys and relieving the depressed liver to remove blood stasis, ligustrazin hydrochloricde injection and He-Ne laser therapy, and a control group (of 36 cases) treated with oral administration of Vitamin E and Vitamin C plus external application of 20% Azelaic acid cream.Results:The total effective rate in the treatment group was 79.6%, which was significantly higher than that of the control group (P<0.05).After treatment, the LPO level in the treatment group was significantly lowered (P<0.01), and the SOD level was significantly elevated (P<0.05).Conclusion:The therapeutic methods adopted in the treatment group may show the action of antioxidation, providing good clinical effects for treating chloasma.

  20. A study on standardization of dispensing procedure for small packages of Chinese herbal pieces%中药小包装饮片调剂操作流程规范化的研究

    Institute of Scientific and Technical Information of China (English)

    王陶丽; 刘玉芹; 刘灿坤

    2014-01-01

    Objective To establish a unified dispensing procedure for small packages of Chinese herbal pieces and to make it standardized so as to operate it easily, save time and energy, provide convenience for examination, avoid mistakes and eliminate medical disputes.MethodsA convenient and reliable, time and energy saving and scientific dispensing procedure was established according to the standardized dispensing procedure of Chinese herbal pieces, the features of small packages, and real working and operating experience.ResultsThe dispensing procedure for small packages of herbal pieces was different from that of Chinese herbal pieces in that its operational procedure and examination had unique functions. The main operational points included investigating, arranging, viewing, comparing, holding, weighing, allocating, examining, packaging, and dispatching. Conclusion Small packages of Chinese herbal pieces solve the problems of Chinese herbal pieces which are not easy to keep, allocate and maintain, as well as the problems during dispensing such as complicated weighing, uneven size, inaccurate weight, unfavorable condition for re-examination, messy environment and low quality; advantages such as one type of drug in one bag, easy identification, accurate weighing, easy check and exchange by name and drug, and informed consent for patients are ensured.%目的:制定统一中药小包装饮片的调剂操作流程,使其规范化、标准化、有利于操作,省时省力,便于审核,防止差错,杜绝医疗纠纷的发生。方法依据中药饮片的调剂规范流程,结合小包装饮片的特点,根据实际操作工作经验,制定便捷可靠、省时省力、科学操作的工艺流程。结果小包装饮片完全不同于中药饮片的调剂,其操作方法、审核等具有独特的操作性能,审、摆、看、对、拿、掂、分、核、包、发是其主要操作要点。结论中药小包装饮片解决了中药饮片不利于保管

  1. Effects of Chinese Herbal Medicine Prescriptions on Reproduction Performance of Transition Period Dairy Cows%复方中草药添加剂对围产期奶牛繁殖性能的影响

    Institute of Scientific and Technical Information of China (English)

    王煦; 宋元振

    2016-01-01

    The objective of study was to investigate the effects of Chinese herbal medicine additive on reproduction performance of perinatal dairy cows,and to provide theoretical basis and methods to exert the production performance of dairy cows. Totally 32 Chinese Holstein dairy cows with similar calving date,parity,milk production were randomly divided into 4 groups:control group,group A,group B,and group C.The control group fed diet,the experimental group added prescription Chinese herbal medicine from prenatal 21 days to postpartum 21days(total 42 days).The amount of Chinese herbal medicine added in Group A,Group B,and Group C is respectively 50g/d,100g/d,and 150g/d. The results show that The hormone secrection about cow's reproduction,ifrst estrus,during postpartum 70 day cows estrus ratio and calving interval were improved by adding Chinese herbal medicine to dietary during postpartum.It is indicate that the cows repreduction performance were improved by adding Chinese herbal medicine to dietary during postpartum.%本试验旨在探讨在基础日粮中添加复方中草药对围产期奶牛生殖激素的影响,以期为更好地发挥奶牛的遗传潜力提供理论依据。选用健康的围产期荷斯坦牛32头,按照年龄相近、胎次相近、预产期相近的原则,随机分成4组,对照组饲喂常规基础日粮,处理A组、处理B组、处理C组在基础日粮基础上添加复方中草药,从产前21d~产后21d连续饲喂42d,添加量分别为50g/d、100g/d、150g/d。结果表明:奶牛围产期日粮中添加复方中草药可促进围产期奶牛生殖激素的分泌,促进遗传潜力的发挥;奶牛围产期日粮中添加复方中草药可提高第一情期受胎率、产后70d内第一次发情的母牛比率,缩短分娩至产后第一次配种间隔天数和产犊间隔,促进奶牛产后体况恢复,提高奶牛的繁殖性能。

  2. 中药材扑克牌式趣味学习卡的设计与应用%Design and Application of Poker-like Funny Learning Card for Chinese Herbal Medicine

    Institute of Scientific and Technical Information of China (English)

    黄小方; 欧阳辉; 傅国强; 曾鸿鹄; 敖梅英

    2012-01-01

    目的:为提高中医药教学水平提供借鉴.方法:通过品种选编、图片采集、知识整理、样品制作等,设计制作扑克牌式学习卡,将常用中药材的实物彩图与知识要点印制成扑克牌形式的趣味学习卡,作为《中药材》等课程教学用品,并在《中药材》课堂进行应用与测评.结果:学习卡共设计5辑,每辑含4副扑克牌式学习卡,分别为原植物彩图、药材彩图、中文知识要点、英文知识要点.初样在实际教学应用中效果较好,通过扑克游戏和趣味记忆让学生掌握知识.结论:中药材扑克牌式趣味学习卡设计美观大方,简便易用,知识性与趣味性强,寓教于乐,能有效地促进教学效果,是教学良好的辅助工具,在中医药教学中具有开创性和启发性.%OBJECTIVE: To provide reference for improving teaching level of Chinese Herbal Medicine. Poker-like funny learning cards printed with pictures and knowledge tips of common used can be applied as study facilities, it is designed and applied to enhance learning enthusiasm of students. METHODS: Design process included species selection, picture collection, knowledge tips compilation, learning card samples preparation and so on. The color graph and knowledge point of Chinese herbal medicine were made into poker-like funny learning card as realia of course of Chinese Herbal Medicine. The learning card was applied and tested in the class of Chinese Herbal Medicine. RESULTS: There were 5 series of learning cards, each series contained 4 pokers: the original plant color graph, medicinal materials color graph, Chinese knowledge points, English knowledge points. The applied samples achieved good effect in the teaching practice, and students can master the knowledge easily with poker games and interesting memory methods. CONCLUSIONS: The design of poker-like funny learning card for Chinese Herbal Medicine is artistic, graceful, concise and convenient. The cards are full of

  3. The rationality of the hypolipidemic effect of alismatis rhizoma decoction, a classical chinese medicine formula in high-fat diet-induced hyperlipidemic mice.

    Science.gov (United States)

    Song, Chengwu; Huang, Xiaofei; Lu, Kungang; Peng, Min; Yu, Shanggong; Fang, Nianbai

    2014-01-01

    Alismatis Rhizoma Decoction (ARD) is a classical Traditional Chinese Medicine (TCM) formula for treatment of vertigo with its long history of successful clinical effect. Since vertigo is a symptom of hyperlipidemia, this study aimed at evaluating the hypolipidemic effect of ARD in hyperlipidemic mice induced by high fat diet (HFD) and investigated the rationality of formula combination of Alismatis Rhizoma (AR) and Atractylodis Macrocephalae Rhizoma (AMR). Compared with control group, hyperlipidemic mice in AR and ARD groups displayed a reduction of the following parameters: body weight, liver and serum total cholesterol, triglyceride concentration, liver and spleen coefficients, activities of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT); whereas the serum HDL-cholesterol levels were significantly elevated in both AR and ARD groups. AR and ARD treatments significantly down regulated the expressions of 3-hydroxy-3-methylglutharyl-coenzyme A reductase (HMG-CoA reductase) and sterol regulatory element binding factor-2 (SREBF-2). These findings clearly provided evidences that the suppression on biosynthesis of cholesterol in liver may in part contribute to the hypolipidemic effects of ARD and AR. Since no significantly hypolipidemic effect of AMR was observed, the more prominent effect of ARD than that of AR indicated synergistic effects of AR and AMR, and confirmed the rationality of ARD formula.

  4. 扶正减毒颗粒在肺癌及食管癌放疗中的应用观察%The Effect of Chinese herbal medicine in the treatment of lung and esophagus cancer treated with radiotherapy

    Institute of Scientific and Technical Information of China (English)

    黄辉; 郭明; 徐鹏飞; 魏鹏飞

    2011-01-01

    目的:评价中成药扶正减毒颗粒在肺癌及食管癌放疗中所起作用.方法:对80例食管癌及肺癌放疗患者随机分成用药组和对照组,用药组40例患者饭前半小时温开水200毫升冲服扶正减毒颗粒,3次/日,1袋/次,从放疗开始服用至放疗结束,对照组饭前半小时服用200毫升温开水.对比放疗前后各种指标的变化情况.结果:用药组在减轻放疗损伤方面疗效明显,尤其在口干、纳呆、乏困、咽下疼痛和心烦失眠方面,扶正减毒颗粒可以明显减轻不良反应.结论:在肺癌和食管癌放疗期间配合服用中药扶正减毒颗粒可以起到明显的减毒、改善临床症状的作用.%Objective: To evulate the effect in the treatment of lung cancer and esophagus with radiotherapy combinded Chinese herbal medicine.Methods: Total of 40 patients were treated with radiotherapy and herbal medicine, Chinese herbal medicine -Fuzhengjiandukeli was taken 30 minutes before the dinner, another 40 patients were treated with radiotherapy only.Results :The observed group in reducing radiation damage efficacy was obvious, especially in dry mouth, natrium stay, deficient trapped, swallow pain and upset insomnia, centralizer reduction poison particles can significantly reduce adverse reaction.Conclusion: The Chinese herbal medicine - Fuzhengjiandukeli can effectively prevent and improve clinical symptoms indaced by radiotherapy in lung cancer and esophagus cancer.

  5. Pharmacokinetics of the main compounds absorbed into blood after oral administration of Liu Wei Di Huang Wan, a typical combinatorial intervention of Chinese medical formula.

    Science.gov (United States)

    Zhang, Ning; Li, Lijing; Wang, Ping; Sun, Hui; Wu, Zeming; Piao, Chengyu; Wang, Xijun

    2013-01-01

    Liu Wei Di Huang Wan (LW) has been used as an active Chinese patent formula for "Five Late Syndrome" of Children for thousands of years. Due to the complexity in its chemical constituents, the pharmacokinetics of this formula have not been elucidated clearly, and the understanding of its pharmacological properties has been delayed. Previous studies have identified the constituents absorbed into blood after the oral administration of LW; moreover, 5-hydroxymethyl-2-furoic acid (HMFA), loganin and paeonol have been proved as surrogate markers. In this study, a rapid validated high-performance liquid chromatography method was developed for determining three marker compounds in plasma. The analysis was performed on a Waters Symmetry Shield™ RP(18) column with acetonitrile and 0.15% phosphoric acid as the mobile phase, which showed acceptable linearity, intra- and inter-day precision, and accuracy. By using the established method, the pharmacokinetic analysis of LW was carried out. The t (1/2)α and t (1/2)β were 2.62/32.66, 0.46/4.71 and 1.30/23.51 h and the climax times and concentrations were 0.56/683.75, 0.70/2826.11 and 0.62 h/4030.48 ng ml(-1) for HMFA, loganin and paeonol, respectively. Especially, both the absorption and disposition of HMFA were swift (t (1/2) kα 0.1 h, t (1/2)α 2.62 h), but the elimination was quite slow (t (1/2)β 32.66 h); this phenomenon reflected the synergetic effect of LW combinatorial intervention and the value of compatibility can be more clearly understood. The pharmacokinetic characters of HMFA, loganin and paeonol not only elucidated the steady and long-lasting pharmacological properties, but they also revealed the practical value of the compatibility of Chinese medical formula.

  6. 几味常用中药材非药用部位或混淆品入药现象分析%Analysis of Non-medicinal Parts and Adulterant of Chinese Herbal Medicine Used as Medicine

    Institute of Scientific and Technical Information of China (English)

    李勇

    2014-01-01

    OBJECTIVE:To analyze the phenomenon of non-medicinal parts and adulterant of Chinese herbal medicine used as medicine.METHODS:The property,physicochemical property and pesticide effects were indentified in authentic and fake Uncaria tomentosa,Polygala tenuifolia,Cryptotympana pustulata,Rubia cordifolia and the thorn of Gleditsia sinensis.RESULTS:Pesticide effects of non-medicinal parts were worse than authentic medicine or opposite to authentic medicine,and adulterant had no pesticide effects even had toxic effects.CONCLUSIONS:Non-medicinal parts and adulterant has a severe impact on pesticide effects of Chinese herbal medicine.%目的:防止中药材非药用部位或混淆品入药.方法:对钩藤、远志、蝉蜕、茜草、皂荚刺的正伪品性状、理化性状及药效进行鉴别.结果:非药用部位的药效差于正品或者药效相反,混淆品一般无药用价值甚至有毒副作用.结论:非药用部位或混淆品入药会严重影响中药的药效,甚至危害患者.

  7. 医用乳酸菌对常用中草药的耐药性试验%Drug resistance test of medicinal lactic acid bacteria to common Chinese herbal medicines

    Institute of Scientific and Technical Information of China (English)

    王世荣; 杨丙田; 宋青楠; 王延秋; 王霞

    2013-01-01

    目的 研究医用乳酸菌对几种常用中草药的耐药性,为医用乳酸菌与中草药的临床合并应用提供理论依据.方法 将中草药制成煎剂,通过琼脂扩散方法进行耐药性试验.结果 5种医用乳酸菌对黄连均表现出中度敏感,对黄芩表现微弱敏感.结论 5种医用乳酸菌对大部分中草药(包括有抗菌和抑菌作用的中草药)不敏感.%Objective To study (he drug resistance of medicinal lactic acid bacteria to several common Chinese herbal medicines, and provide theoretical basis for clinical application of the combinations of herbs and lactic acid bacteria. Methods Drug resistance was detected by using agar diffusion test. Results The five kinds of medicinal lactic acid bacteria were all moderately sensitive to Rhizoma Coptidis and slightly sensitive to Scutellaria Baicalensis. Conclusion The five kinds of medicinal lactic acid bacteria are not sensitive to most Chinese herbal medicines including the herbs with have antimicrobial effect and antibacterial effects.

  8. 中草药防治放射性口干症的研究进展%Progress of Chinese Herbal Medicine for Prevention and Treatment of Radioactive Xerostomia

    Institute of Scientific and Technical Information of China (English)

    张海东

    2012-01-01

    Radioactive xerostomia is due to the changes of saliva in number, property and composition which caused by radiation damage to salivary glands of head and neck cancer patients after radiation radiotherapy. The prevention and treatment of radioactive xerostomia includes reducing the exposed volume and preventively administration of drugs. Chinese herbal medicine has played an active role in the prevention against radiation xerostomia. Scholars have applied Chinese herbal medicine to radiotherapy for head and neck cancer to improve local control rate and relieve, the pain caused by xerostomia and achieve good effect.%放射性口干症是因接受放疗的头颈部肿瘤患者其唾液腺受到照射后发生损伤,唾液分泌的数量、性质、成分改变所引起的,对其防治主要包括减少暴露体积、预防性使用药物.中草药在防治放射性口干症方面发挥了积极的作用,学者们运用具有活血化瘀、养阴生津的中药辅助头颈部肿瘤的放疗对提高局部控制率、缓解放疗中口干疼痛的不良反应取得了较好的效果.

  9. 14种中草药对常见畜禽病原菌的体外抗菌研究%Bacteriostatic Test in vitro of 14 Chinese Herbal Medicines Against Common Pathogenic Bacteria of Livestock and Poultry

    Institute of Scientific and Technical Information of China (English)

    王伟; 魏磊; 王学方; 李晓; 董建军

    2015-01-01

    To study the effects of antibacterial activity of Chinese herbal medicine extracts ,the antibacterial activity of 14 Chinese herbal medicines to Escherichia coli,Staphylococcus aureu,Streptococcus pyogenes,Salmonella typhimurium, Streptococcus pneumonia,chicken Escherichia coli,chicken Staphylococcus aureu,Salmonella pullorum and Staphylococcus agalactiae was tested by filtering paper method and microdilution method. The extracts of honeysuckle flower ,fructus forsythiae,radix scutellar,rhizoma coptidis and cortex phellodendri chinensis have effective antibacterial activity.%为研究中草药提取物对畜禽常见病原菌的抑制作用,采用微量二倍稀释法和滤纸片法测定了14种中草药提取物对大肠杆菌、金黄色葡萄球菌、化脓性链球菌、鼠伤寒沙门氏菌、肺炎链球菌、鸡大肠杆菌、鸡金黄色葡萄球菌、鸡白痢沙门氏菌和牛无乳链球菌的抑制作用。结果表明:金银花、连翘、黄芩、黄连和黄檗具有良好的抗菌活性。

  10. A position statement on kidney disease from powdered infant formula-based melamine exposure in Chinese infants.

    Science.gov (United States)

    Langman, Craig B; Alon, Uri; Ingelfinger, Julie; Englund, Märta; Saland, Jeffrey M; Somers, Michael J G; Stapleton, F Bruder; Sibú, Nelson Orta; Cochat, Pierre; Wong, William; Eke, Felicia U; Satlin, Lisa; Salusky, Isidro

    2009-07-01

    Melamine, a man-made non-nutritive substance containing nitrogen, can falsely elevate measures of protein content in foodstuffs. Several manufacturers of powdered infant formula in China apparently added melamine to raise the measured protein content and thereby exposed thousands of infants and young children to very high levels of melamine. Such exposure resulted in cases of acute kidney failure and nephrolithiasis. This Editorial from members of the world-wide Pediatric Nephrology community provides a common-sense approach to the care of infants who may have been exposed to powdered infant formula in 2007-2008.

  11. [Cloud Point extraction for determination of mercury in Chinese herbal medicine by hydride generation atomic fluorescence spectrometry with optimization using Box-Behnken design].

    Science.gov (United States)

    Wang, Mei; Li, Shan; Zhou, Jian-dong; Xu, Ying; Long, Jun-biao; Yang, Bing-yi

    2014-08-01

    Cloud point extraction (CPE) is proposed as a pre-concentration procedure for the determination of Hg in Chinese herbal medicine samples by hydride generation-atomic fluorescence spectrometry (HG-AFS). Hg2+ was reacted with dithizone to form hydrophobic chelate under the condition of pH. Using Triton X-114, as surfactant, chelate was quantitatively extracted into small volume of the surfactant-rich phase by heating the solution in a water bath for 15 min and centrifuging. Four variables including pH, dithizone concentration, Triton X-114 concentration and equilibrium temperature (T) showed the significant effect on extraction efficiency of total Hg evaluated by single-factor experiment, and Box-Behnken design and response surface method- ology were adopted to further investigate the mutual interactions between these variables and to identify their optimal values that would generate maximum extraction efficiency. The results showed that the binomial was used to fit the response to experimental levels of each variable. ALL linear, quadratic terms of four variables, and interactions between pH and Trion X-114, pH and di- thizone affected the response value(extraction efficiency) significantly at 5% level. The optimum extraction conditions were as follows: pH 5.1, Triton X-114 concentration of 1.16 g x L(-1), dithizone concentration of 4.87 mol x L(-1), and T 58.2 degrees C, the predicted value of fluorescence was 4528.74 under the optimum conditions, and the experimental value had only 2.1% difference with it. Under the conditions, fluorescence was linear to mercury concentration in the range of 1-5 microg x L(-1). The limit of detection obtained was 0.01247 microg x L(-1) with the relative standard deviations (R.S.D.) for six replicate determinations of 1.30%. The proposed method was successfully applied to determination of Hg in morindae Radix, Andrographitis and dried tangerine samples with the recoveries of 95.0%-100.0%. Apparently Box-Behnken design combined with

  12. Clinical effect of Chinese herbal medicine Jiaweisimiaowan on gout%中药四妙丸加味治疗痛风的临床观察

    Institute of Scientific and Technical Information of China (English)

    宁波; 王新宴; 王文清

    2008-01-01

    目的 探讨痛风及高尿酸血症患者的异同及四妙丸加味治疗痛风的机制.方法 观察30例缓解期痛风患者、32例高尿酸血症患者和31名健康对照者超敏C反应蛋白(hsCRP)、胰岛素抵抗、尿酸、胆固醇、甘油三酯的区别.痛风组服用中药四妙丸加味14 d后复查hsCRP、胰岛素抵抗和尿酸.结果 痛风组hsCRP显著高于高尿酸血症组及健康对照组(P<0.01),服用中药治疗后痛风组hsCRP显著下降(P<0.01),尿酸变化无统计学意义.结论 中药四妙丸加味可能是通过减轻炎症反应达到治疗目的 .%Objective To investigate difference between gout and hyperuricemia patients and mechanism of treatment of Chinese herbal medicine Jiaweisimiaowan on gout.Methods Gout group(n=30),simple hyperuricemia group(n=32)and control group(n=31)were observed.Patients of gout group took Jiaweisimiaowan for 14 days.Levels of blood high sensitive C reactive protein(hsCRP),resistance of insulin,uric acid,cholesterol and triglycerides were measured.Results hsCRP in gout group was obviously higher than that in hyperuricemia group and control group(P<0.01).There were no difference in resistance of insulin,cholesterol and triglycerides between gout and hyperuricemia group.hsCRP in gout group was obviously lower after taking Jiaweisimiaowan while uric acid did not change.Conclusions Jiaweisimiaowan has effect of anti-inflammation on gout patients.

  13. Antidepressant-like effects of the ethanolic extract of Xiaobuxin-Tang, a traditional Chinese herbal prescription in animal models of depression

    Institute of Scientific and Technical Information of China (English)

    ZHANG You-zhi; LI Yun-feng; YU Neng-jiang; YUAN Li; ZHAO Yi-min; XIAO Wen-bin; LUO Zhi-pu

    2007-01-01

    Background Xiaobuxin-Tang, a traditional Chinese herbal prescription recorded in a silk scroll unearthed from Mogao Caves of Dunhuang has been indicated that it can remit depressive disorder. The present study was designed to investigate its antidepressant effects in various animal depression models.Methods Xiaobuxin-Tang was extracted by 70% alcohol, and then three behavioral despair models and 5-Hydroxytryptophan (HTP)-induced head twitch response model were adopted to assess the antidepressant effects of the ethanolic extract of Xiaobuxin-Tang with the study on spontaneous motor activity. Groups of mice and rats received oral treatment with Xiaobuxin-Tang (150-1200 mg/kg) only once acutely in all tests. The duration of immobility was measured during the last 4 minutes of the 6-minutes test period in mice forced swimming test, rats forced swimming test and mice tail suspension test. In 5-HTP-induced head twitch response, the mice were intraperitoneally administered with 120 mg/kg of L-5-HTP, and then the cumulative number of head twitches was counted in 20 minutes. Spontaneous motor activities of mice were recorded automatically in 10 minutes by VIDEOMEX-V image analyticsystem.Results The extract at doses of 300 mg/kg (p.o.) and 600 mg/kg (p.o.) significantly decreased the duration of immobility time in a dose dependent manner in mice forced swimming test; also, the extract at dose of 1200 mg/kg (p.o.)significantly decreased the duration of immobility time in rat forced swimming test. Furthermore, the extract at a dose of 600 mg/kg had the same effect in mice tail suspension test. Meanwhile, the extract at the effective doses for behavioral despair models, had no effect on spontaneous motor activity in mice. The extract (300-1200 mg/kg, p.o.) also increased the accumulative number of the 5-HTP-induced head twitch response in mice in 20 minutes.Conclusion Our results suggested that the ethanolic extract of Xiaobuxin-Tang exerts antidepressant-like effect.

  14. 三种中草药抗氧化性研究%Study on Antioxidant Activities of Three Types of Chinese Herbal Medicines

    Institute of Scientific and Technical Information of China (English)

    韩明; 蔺志铎; 薛福玲; 吴冬青

    2009-01-01

    The microware assisted extraction technique was used to extract flavonids from Geranium wilfordii Maxim, Siegesbeckia orientalis L.,Oldenlandia diffusa (Willd.) Roxb. Meanwhile, the antioxidative activities of three types of Chinese herbal medicines were studied by determining the reducing capacity, antioxidative activity in lipid and scavenging effects on hydroxyl radical. The flavonoid content from theirs were Geranium wilfordii Maxim (132. 516 mg/g), Siegesbeckia orientalis L. (78.4749mg/g),Oldenlandia diffusa(Willd.) Roxb(35. 6519rag/g). The extract had strong reducing capacity and scavenging effects on hydroxyl radical,scavenging effects on hydroxyl radical were positive correlation to extract concentration, and also the extraction possessed antioxidant activities in lipid. Their antioxidant activities had difference. This work offers the new scientific data for the further studies of comprehensive utilization of the Herb resource.%微波辅助法提取3种中草药中黄酮类化合物,从还原能力、清除羟基自由基和抗油脂氧化方面,研究其抗氧化活性.结果表明:3种中草药中,总黄酮含量从高到低依次为:老鹤草(132.516mg/g)、稀莶草(78.4749mg/g)、白花蛇舌草(35.6519mg/g).其提取物具有较好的还原能力,且对羟基自由基均有明显的清除作用,其清除效果随提取物浓度的增加而增强.三种中草药提取物也具有一定的抗油脂氧化能力,它们的抗氧化能力存在差异.实验结果为我们更加合理开发利用这些药用植物提供了很好的科学依据.

  15. Can Chinese herbal medicine improve outcomes of in vitro fertilization? A systematic review and meta-analysis of randomized controlled trials.

    Directory of Open Access Journals (Sweden)

    Huijuan Cao

    Full Text Available BACKGROUND: A large number of infertile couples are choosing Chinese herbal medicine (CHM as an adjuvant therapy to improve their success when undergoing in vitro fertilization (IVF. There is no systematic review to evaluate the impact of CHM on the IVF outcomes. OBJECTIVE: To evaluate the effectiveness of CHM with concurrent IVF versus IVF alone on the outcomes of IVF and its safety. METHODS: The protocol of this study is registered at PROSPERO. Eligible RCTs searched from 8 databases which compared a combination of CHM and IVF with IVF alone were included. Two authors independently selected studies, extracted data and assessed methodological quality. Meta-analysis of RCTs was conducted if there was non-significant heterogeneity (evaluated by I(2 test among trials. All statistical analysis was performed using RevMan 5.1 software. RESULTS: Twenty trials involving 1721 women were included in the meta-analysis. Three trials were evaluated as having an unclear risk of bias. The remaining trials were evaluated as having a high risk of bias. Combination of CHM and IVF significantly increases clinical pregnancy rates (OR 2.04, 95%CI 1.67 to 2.49, p<0.00001 and ongoing pregnancy rates (OR 1.91, 95%CI 1.17 to 3.10, p = 0.009. Use of CHM after embryo transfer had no better outcome in reducing the rate of ovarian hyper stimulation syndrome (OR 0.39, 95%CI 0.14 to 1.11, p = 0.08. CONCLUSIONS: This meta-analysis showed that combination of IVF and CHM used in the included trials improve IVF success, however due to the high risk of bias observed with the trials, the significant differences found with the meta-analysis are unlikely to be accurate. No conclusion could be drawn with respect to the reproductive toxicity of CHM. Further large randomized placebo controlled trials are warranted to confirm these findings before recommending women to take CHM to improve their IVF success.

  16. Comparative in vitro dissolution of two commercially available Er-Zhi-Wan herbal medicinal products

    Directory of Open Access Journals (Sweden)

    M Wang

    2015-01-01

    Full Text Available In vitro dissolution test is an essential tool to assess the quality of herbal medicinal products in the solid dosage forms for oral use. Our work aimed to evaluate the dissolution behavior of Er-Zhi-Wan, in the formulations of water-honeyed pill and formula granule. Different media (water, 30% EtOH, 0.1 M HCl, acetate buffer, pH 4.5 and phosphate buffer, pH 6.8 were used following United States Pharmacopoeia and Chinese Pharmacopeia. An ultra-high performance liquid chromatography method was developed and validated to detect simultaneously six active ingredients for quantification and dissolution study (salidroside, specnuezhenide, nuezhenoside, luteolin, apigenin, oleanolic acid. As we observed, contents of main active ingredients were close in the two formulations for daily dose. In each medium, more ingredients dissolved from formula granule with higher Ymax and Ka. The mean dissolution time of the most ingredients in granule was significantly shorter than that in pill in acetate buffer, pH 4.5 and phosphate buffer, pH 6.8. Furthermore, salidroside, specnuezhenide and luteolin dissolved more than 80% in 30 min from formula granule, which indicated higher solubility along the intestinal tract according to biopharmaceutics classification system. The dissolution test developed and validated was adequate for its purposes and could be applied for quality control of herbal medicine. This work also can be used to provide necessary information on absorption for its biopharmaceutical properties.

  17. Illustration of compositional variations over time of Chinese porcelain glazes combining micro-X-ray Fluorescence spectrometry, multivariate data analysis and Seger formulas

    Science.gov (United States)

    Van Pevenage, J.; Verhaeven, E.; Vekemans, B.; Lauwers, D.; Herremans, D.; De Clercq, W.; Vincze, L.; Moens, L.; Vandenabeele, P.

    2015-01-01

    In this research, the transparent glaze layers of Chinese porcelain samples were investigated. Depending on the production period, these samples can be divided into two groups: the samples of group A dating from the Kangxi period (1661-1722), and the samples of group B produced under emperor Qianlong (1735-1795). Due to the specific sample preparation method and the small spot size of the X-ray beam, investigation of the transparent glaze layers is enabled. Despite the many existing research papers about glaze investigations of ceramics and/or porcelain ware, this research reveals new insights into the glaze composition and structure of Chinese porcelain samples. In this paper it is demonstrated, using micro-X-ray Fluorescence (μ-XRF) spectrometry, multivariate data analysis and statistical analysis (Hotelling's T-Square test) that the transparent glaze layers of the samples of groups A and B are significantly different (95% confidence level). Calculation of the Seger formulas, enabled classification of the glazes. Combining all the information, the difference in composition of the Chinese porcelain glazes of the Kangxi period and the Qianlong period can be demonstrated.

  18. Monitoring of mercury, arsenic, and lead in traditional Asian herbal preparations on the Dutch market and estimation of associated risks

    NARCIS (Netherlands)

    Martena, M.J.; Wielen, van der J.C.A.; Rietjens, I.; Klerx, W.N.M.; Groot, de H.N.; Konings, E.J.M.

    2010-01-01

    Traditional herbal preparations used in Ayurveda, traditional Chinese medicine, traditional Tibetan medicine, and other Asian traditional medicine systems may contain significant amounts of mercury, arsenic or lead. Though deliberately incorporated in Asian traditional herbal preparations for therap

  19. Therapeutic Actions of the Chinese Herbal