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Sample records for china high-intensity accelerator

  1. High Intensity Accelerator and Neutron Source in China

    Science.gov (United States)

    Guan, Xialing; Wei, J.; Loong, Chun

    2011-06-01

    High intensity Accelerator is being studied all over world for numerous applications, which includes the waste transmutation, spallation neutron source and material irradiation facilities. The R/D activities of the technology of High intensity accelerator are also developed in China for some year, and have some good facilities around China. This paper will reports the status of some high intensity accelerators and neutron source in China, which including ADS/RFQ; CARR; CSNS; PKUNIFTY & CPHS. This paper will emphatically report the Compact Pulsed Hadron Source (CPHS) led by the Department of Engineering Physics of Tsinghua University in Beijing, China.

  2. High-Intensity Proton Accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Jay L. Hirshfield

    2011-12-27

    Analysis is presented for an eight-cavity proton cyclotron accelerator that could have advantages as compared with other accelerators because of its potentially high acceleration gradient. The high gradient is possible since protons orbit in a sequence of TE111 rotating mode cavities of equally diminishing frequencies with path lengths during acceleration that greatly exceed the cavity lengths. As the cavities operate at sequential harmonics of a basic repetition frequency, phase synchronism can be maintained over a relatively wide injection phase window without undue beam emittance growth. It is shown that use of radial vanes can allow cavity designs with significantly smaller radii, as compared with simple cylindrical cavities. Preliminary beam transport studies show that acceptable extraction and focusing of a proton beam after cyclic motion in this accelerator should be possible. Progress is also reported on design and tests of a four-cavity electron counterpart accelerator for experiments to study effects on beam quality arising from variations injection phase window width. This device is powered by four 500-MW pulsed amplifiers at 1500, 1800, 2100, and 2400 MHz that provide phase synchronous outputs, since they are driven from a with harmonics derived from a phase-locked 300 MHz source.

  3. Particle Accelerators in China

    Science.gov (United States)

    Zhang, Chuang; Fang, Shouxian

    As the special machines that can accelerate charged particle beams to high energy by using electromagnetic fields, particle accelerators have been widely applied in scientific research and various areas of society. The development of particle accelerators in China started in the early 1950s. After a brief review of the history of accelerators, this article describes in the following sections: particle colliders, heavy-ion accelerators, high-intensity proton accelerators, accelerator-based light sources, pulsed power accelerators, small scale accelerators, accelerators for applications, accelerator technology development and advanced accelerator concepts. The prospects of particle accelerators in China are also presented.

  4. ELECTRON CLOUD EFFECTS IN HIGH INTENSITY PROTON ACCELERATORS.

    Energy Technology Data Exchange (ETDEWEB)

    WEI,J.; MACEK,R.J.

    2002-04-14

    One of the primary concerns in the design and operation of high-intensity proton synchrotrons and accumulators is the electron cloud and associated beam loss and instabilities. Electron-cloud effects are observed at high-intensity proton machines like the Los Alamos National Laboratory's PSR and CERN's SPS, and investigated experimentally and theoretically. In the design of next-generation high-intensity proton accelerators like the Spallation Neutron Source ring, emphasis is made in minimizing electron production and in enhancing Landau damping. This paper reviews the present understanding of the electron-cloud effects and presents mitigation measures.

  5. Annotated bibliography on high-intensity linear accelerators. [240 citations

    Energy Technology Data Exchange (ETDEWEB)

    Jameson, R.A.; Roybal, E.U.

    1978-01-01

    A technical bibliography covering subjects important to the design of high-intensity beam transport systems and linear accelerators is presented. Space charge and emittance growth are stressed. Subject and author concordances provide cross-reference to detailed citations, which include an abstract and notes on the material. The bibliography resides in a computer database that can be searched for key words and phrases.

  6. The joint project for high-intensity proton accelerators

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-08-01

    Japan Atomic Energy Research Institute (JAERI) and the High Energy Accelerator Research Organization (KEK) agreed to promote the joint project integrating both the Neutron Science Project (NSP) of JAERI and the Japan Hadron Facility Project (JHF) of KEK for comprehensive studies on basic science and technology using high-intensity proton accelerator. This document describes the joint proposal prepared by the Joint Project Team of JAERI and KEK to construct accelerators and research facilities necessary both for the NSP and the JHF at the site of JAERI Tokai Establishment. (author)

  7. Advanced approaches to high intensity laser-driven ion acceleration

    Energy Technology Data Exchange (ETDEWEB)

    Henig, Andreas

    2010-04-26

    Since the pioneering work that was carried out 10 years ago, the generation of highly energetic ion beams from laser-plasma interactions has been investigated in much detail in the regime of target normal sheath acceleration (TNSA). Creation of ion beams with small longitudinal and transverse emittance and energies extending up to tens of MeV fueled visions of compact, laser-driven ion sources for applications such as ion beam therapy of tumors or fast ignition inertial con finement fusion. However, new pathways are of crucial importance to push the current limits of laser-generated ion beams further towards parameters necessary for those applications. The presented PhD work was intended to develop and explore advanced approaches to high intensity laser-driven ion acceleration that reach beyond TNSA. In this spirit, ion acceleration from two novel target systems was investigated, namely mass-limited microspheres and nm-thin, free-standing diamond-like carbon (DLC) foils. Using such ultrathin foils, a new regime of ion acceleration was found where the laser transfers energy to all electrons located within the focal volume. While for TNSA the accelerating electric field is stationary and ion acceleration is spatially separated from laser absorption into electrons, now a localized longitudinal field enhancement is present that co-propagates with the ions as the accompanying laser pulse pushes the electrons forward. Unprecedented maximum ion energies were obtained, reaching beyond 0.5 GeV for carbon C{sup 6+} and thus exceeding previous TNSA results by about one order of magnitude. When changing the laser polarization to circular, electron heating and expansion were shown to be efficiently suppressed, resulting for the first time in a phase-stable acceleration that is dominated by the laser radiation pressure which led to the observation of a peaked C{sup 6+} spectrum. Compared to quasi-monoenergetic ion beam generation within the TNSA regime, a more than 40 times

  8. Accelerator technical design report for high-intensity proton accelerator facility project, J-PARC

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-03-01

    This report presents the detail of the technical design of the accelerators for the High-Intensity Proton Accelerator Facility Project, J-PARC. The accelerator complex comprises a 400-MeV room-temperature linac (600-MeV superconducting linac), 3-GeV rapid-cycling synchrotron (RCS), and a 50-GeV synchrotron (MR). The 400-MeV beam is injected to the RCS, being accelerated to 3 GEV. The 1-MW beam thus produced is guided to the Materials Life Science Experimental Facility, with both the pulsed spallation neutron source and muon source. A part of the beam is transported to the MR, which provides the 0.75-MW beam to either the Nuclear and Fundamental Particle Experimental Facility or the Neutrino Production Target. On the other hand, the beam accelerated to 600 MeV by the superconducting linac is used for the Nuclear Waster Transmutation Experiment. In this way, this facility is unique, being multipurpose one, including many new inventions and Research and Development Results. This report is based upon the accomplishments made by the Accelerator Group and others of the Project Team, which is organized on the basis of the Agreement between JAERI and KEK on the Construction and Research and Development of the High-Intensity Proton Accelerator Facility. (author)

  9. Beam instrumentation for future high intense hadron accelerators at Fermilab

    Energy Technology Data Exchange (ETDEWEB)

    Wendt, M.; Hu, M.; Tassotto, G.; Thurman-Keup, R.; Scarpine, V.; Shin, S.; Zagel, J.; /Fermilab

    2008-08-01

    High intensity hadron beams of up to 2 MW beam power are a key element of new proposed experimental facilities at Fermilab. Project X, which includes a SCRF 8 GeV H{sup -} linac, will be the centerpiece of future HEP activities in the neutrino sector. After a short overview of this, and other proposed projects, we present the current status of the beam instrumentation activities at Fermilab with a few examples. With upgrades and improvements they can meet the requirements of the new beam facilities, however design and development of new instruments is needed, as shown by the prototype and conceptual examples in the last section.

  10. Accelerator technical design report for high-intensity proton accelerator facility project, J-PARC

    CERN Document Server

    2003-01-01

    This report presents the detail of the technical design of the accelerators for the High-Intensity Proton Accelerator Facility Project, J-PARC. The accelerator complex comprises a 400-MeV room-temperature linac (600-MeV superconducting linac), 3-GeV rapid-cycling synchrotron (RCS), and a 50-GeV synchrotron (MR). The 400-MeV beam is injected to the RCS, being accelerated to 3 GEV. The 1-MW beam thus produced is guided to the Materials Life Science Experimental Facility, with both the pulsed spallation neutron source and muon source. A part of the beam is transported to the MR, which provides the 0.75-MW beam to either the Nuclear and Fundamental Particle Experimental Facility or the Neutrino Production Target. On the other hand, the beam accelerated to 600 MeV by the superconducting linac is used for the Nuclear Waster Transmutation Experiment. In this way, this facility is unique, being multipurpose one, including many new inventions and Research and Development Results. This report is based upon the accompli...

  11. Design concept of radiation control system for the high intensity proton accelerator facility

    CERN Document Server

    Miyamoto, Y; Harada, Y; Ikeno, K

    2002-01-01

    Description is given for the characteristic radiation environment for the High Intensity Proton Accelerator Facility and the design concept of the radiation control system of it. The facility is a large scale accelerator complex consisting of high energy proton accelerators carrying the highest beam intensity in the world and the related experimental facilities and therefore provides various issues relevant to the radiation environment. The present report describes the specifications for the radiation control system for the facility, determined in consideration of these characteristics.

  12. Selected List of Low Energy Beam Transport Facilities for Light-Ion, High-Intensity Accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Prost, L. R. [Fermi National Accelerator Laboratory (FNAL), Batavia, IL (United States)

    2016-02-17

    This paper presents a list of Low Energy Beam Transport (LEBT) facilities for light-ion, high-intensity accelerators. It was put together to facilitate comparisons with the PXIE LEBT design choices. A short discussion regarding the importance of the beam perveance in the choice of the transport scheme follows.

  13. Design concept of radiation control system for the high intensity proton accelerator facility

    Energy Technology Data Exchange (ETDEWEB)

    Miyamoto, Yukihiro; Ikeno, Koichi; Akiyama, Shigenori; Harada, Yasunori [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    2002-11-01

    Description is given for the characteristic radiation environment for the High Intensity Proton Accelerator Facility and the design concept of the radiation control system of it. The facility is a large scale accelerator complex consisting of high energy proton accelerators carrying the highest beam intensity in the world and the related experimental facilities and therefore provides various issues relevant to the radiation environment. The present report describes the specifications for the radiation control system for the facility, determined in consideration of these characteristics. (author)

  14. Final Report for "Modeling Electron Cloud Diagnostics for High-Intensity Proton Accelerators"

    Energy Technology Data Exchange (ETDEWEB)

    Seth A Veitzer

    2009-09-25

    Electron clouds in accelerators such as the ILC degrade beam quality and limit operating efficiency. The need to mitigate electron clouds has a direct impact on the design and operation of these accelerators, translating into increased cost and reduced performance. Diagnostic techniques for measuring electron clouds in accelerating cavities are needed to provide an assessment of electron cloud evolution and mitigation. Accurate numerical modeling of these diagnostics is needed to validate the experimental techniques. In this Phase I, we developed detailed numerical models of microwave propagation through electron clouds in accelerating cavities with geometries relevant to existing and future high-intensity proton accelerators such as Project X and the ILC. Our numerical techniques and simulation results from the Phase I showed that there was a high probability of success in measuring both the evolution of electron clouds and the effects of non-uniform electron density distributions in Phase II.

  15. Proceedings of the third ICFA mini-workshop on high intensity, high brightness hadron accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Roser, T.

    1997-11-01

    The third mini-workshop on high intensity, high brightness hadron accelerators was held at Brookhaven National Laboratory on May 7-9, 1997 and had about 30 participants. The workshop focussed on rf and longitudinal dynamics issues relevant to intense and/or bright hadron synchrotrons. A plenary session was followed by four sessions on particular topics. This document contains copies of the viewgraphs used as well as summaries written by the session chairs.

  16. Matched and equipartitioned design method for modern high-intensity radio frequency quadrupole accelerators

    Science.gov (United States)

    Yan, X. Q.; Jameson, R. A.; Lu, Y. R.; Guo, Z. Y.; Fang, J. X.; Chen, J. E.

    2007-07-01

    A new design method—Matched and equipartitioned (EP) design method—has been proposed for radio frequency quadrupole (RFQ) dynamics design, on the considerations of preventing emittance growth and halo formation in high-intensity linacs by means of keeping beam envelope matched and energy balance within the beam, as well as avoiding structure resonances [R.A. Jameson, IEEE Trans. Nucl. Sci. NS-28 (1981) 2408; R.A. Jameson et al., Scaling and optimization in high-intensity linear accelerators, LA-CP-91-272, Los Alamos National Laboratory, July 1991 (introduction of LINACS design code); R.A. Jameson, AIP Conf. Proc. 279 (1992) 969; R.A. Jameson, An approach to fundamental study of beam loss minimization, in: Y.K. Batygin (Ed.), AIP Conference Proceedings, vol. 480, Space Charge Dominated Beam Physics for Heavy Ion Fusion, Saitama, Japan, December 1998]. As there are more than three parameters for a linear accelerator, but only three equations (two envelope equations and an EP equation) are available to design the structural parameters of the RFQ accelerator around the beam, therefore the others have to be determined by additional rules. Following these equations and rules, a new RFQ design code named MATCHDESIGN has been written at Peking University. Three example designs are generated by this code and their simulation results have been compared with a conventional RFQ, which had proved the feasibilities and merits of the new method.

  17. Longitudinal Ion Acceleration from High-Intensity Laser Interactions with Underdense Plasma

    CERN Document Server

    Willingale, L; Nilson, P M; Clarke, R J; Dangor, A E; Kaluza, M C; Karsch, S; Lancaster, K L; Mori, W B; Schreiber, J; Thomas, A G R; Wei, M S; Krushelnick, K; Najmudin, Z

    2007-01-01

    Longitudinal ion acceleration from high-intensity (I ~ 10^20 Wcm^-2) laser interactions with helium gas jet targets (n_e ~ 0.04 n_c) have been observed. The ion beam has a maximum energy for He^2+ of approximately 40 MeV and was directional along the laser propagation path, with the highest energy ions being collimated to a cone of less than 10 degrees. 2D particle-in-cell simulations have been used to investigate the acceleration mechanism. The time varying magnetic field associated with the fast electron current provides a contribution to the accelerating electric field as well as providing a collimating field for the ions. A strong correlation between the plasma density and the ion acceleration was found. A short plasma scale-length at the vacuum interface was observed to be beneficial for the maximum ion energies, but the collimation appears to be improved with longer scale-lengths due to enhanced magnetic fields in the ramp acceleration region.

  18. A conceptual design of the DTL-SDTL for the JAERI high intensity proton accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Ino, Hiroshi; Kabeya, Zenzaburo [Mitsubishi Heavy Industries Ltd., Tokyo (Japan); Chishiro, Etsuji; Ouchi, Nobuo; Hasegawa, Kazuo; Mizumoto, Motoharu

    1998-08-01

    A high intensity proton linear accelerator with an energy of 1.5 GeV and an average beam power of 8 MW has been proposed for the Neutron Science Project (NSP) at JAERI. This linac starts with radio-frequency quadrupole (RFQ) linac, which is followed by a drift-tube linac (DTL), separated-type DTL (SDTL), and a superconducting structure. In this report, we focus on the DTL and SDTL part of the accelerator. The DTL accelerates the beam from 2 to 51 MeV, and SDTL accelerates the beam from 51 to 10 MeV. Since the main features of the requirement for the DTL-SDTL are high peak current ({approx}30 mA) and a high-duty factor ({approx}CW), the conceptual design should be determined not only based on the result of a beam-dynamics calculation, but by careful study of the cooling problems. The design processes of the DTL-SDTL and the matching sections (RFQ to DTL, CW-Pulse merge section, and SDTL to SCC) and the result of a heat transfer analysis of DTL are described. (author)

  19. Design Considerations of Fast Kicker Systems for High Intensity Proton Accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, W; Sandberg, J; Parson, W M; Walstrom, P; Murray, M M; Cook, E; Hartouni, E

    2001-06-12

    In this paper, we discuss the specific issues related to the design of the Fast Kicker Systems for high intensity proton accelerators. To address these issues in the preliminary design stage can be critical since the fast kicker systems affect the machine lattice structure and overall design parameters. Main topics include system architecture, design strategy, beam current coupling, grounding, end user cost vs. system cost, reliability, redundancy and flexibility. Operating experience with the Alternating Gradient Synchrotron injection and extraction kicker systems at Brookhaven National Laboratory and their future upgrade is presented. Additionally, new conceptual designs of the extraction kicker for the Spallation Neutron Source at Oak Ridge and the Advanced Hydrotest Facility at Los Alamos are discussed.

  20. High-intensity laser-accelerated ion beam produced from cryogenic micro-jet target

    Science.gov (United States)

    Gauthier, M.; Kim, J. B.; Curry, C. B.; Aurand, B.; Gamboa, E. J.; Göde, S.; Goyon, C.; Hazi, A.; Kerr, S.; Pak, A.; Propp, A.; Ramakrishna, B.; Ruby, J.; Willi, O.; Williams, G. J.; Rödel, C.; Glenzer, S. H.

    2016-11-01

    We report on the successful operation of a newly developed cryogenic jet target at high intensity laser-irradiation. Using the frequency-doubled Titan short pulse laser system at Jupiter Laser Facility, Lawrence Livermore National Laboratory, we demonstrate the generation of a pure proton beam a with maximum energy of 2 MeV. Furthermore, we record a quasi-monoenergetic peak at 1.1 MeV in the proton spectrum emitted in the laser forward direction suggesting an alternative acceleration mechanism. Using a solid-density mixed hydrogen-deuterium target, we are also able to produce pure proton-deuteron ion beams. With its high purity, limited size, near-critical density, and high-repetition rate capability, this target is promising for future applications.

  1. Special diagnostic methods and beam loss control on high intensity proton synchrotrons and storage rings Circular proton accelerator

    CERN Document Server

    Warsop, C M

    2002-01-01

    Two topics concerning high intensity, medium energy, circular proton accelerators have been studied: specialist diagnostics and beam loss control. The use of specially configured, low intensity diagnostic beams to help measure, understand and control high intensity beams is described. The ideas are developed and demonstrated on the ISIS 800 MeV, high intensity proton synchrotron at the Rutherford Appleton Laboratory in the UK. It is shown that these techniques make much new and valuable information available, which is particularly useful in achieving the precise beam optimisation required for low and controlled losses. Beam loss control in the proposed European Spallation Source (ESS) accumulator rings is studied. The expected losses are summarised, and a design for the beam collimation system presented. A new code for the simulation of loss control is outlined, and then used to test the collimation system under most foreseeable conditions. It is expected that the required loss control levels will be achievab...

  2. Ionization and acceleration of heavy ions in high-Z solid target irradiated by high intensity laser

    Science.gov (United States)

    Kawahito, D.; Kishimoto, Y.

    2016-05-01

    In the interaction between high intensity laser and solid film, an ionization dynamics inside the solid is dominated by fast time scale convective propagation of the internal sheath field and the slow one by impact ionization due to heated high energy electrons coupled with nonlocal heat transport. Furthermore, ionization and acceleration due to the localized external sheath field which co- propagates with Al ions constituting the high energy front in the vacuum region. Through this process, the maximum charge state and then q/A increase in the rear side, so that ions near the front are further accelerated to high energy.

  3. A preliminary study of the feasibility of using superconducting quarter-wave resonators for accelerating high intensity proton beams

    Institute of Scientific and Technical Information of China (English)

    YANG Liu; LU Xiang-Yang; QUAN Sheng-Wen; YAO Zhong-Yuan; LUO Xing; ZHOU Kui

    2012-01-01

    The superconducting (SC) cavities currently used for the acceleration of protons at a low velocity range are based on half-wave resonators.Due to the rising demand on high current,the issue of beam loading and space-charge problems has arisen.Qualities of low cost and high accelerating efficiency are required for SC cavities,which are properly fitted by using SC quarter-wave resonators (QWR).We propose a concept of using QWRs with frequency 162.5 MHz to accelerate high current proton beams.The main factor limiting SC QWRs being applied to high current proton beams is vertical beam steering,which is dominantly caused by the magnetic field on axis.In this paper,we intend to analyze steering and eliminate it to verify the qualification of using QWRs to accelerate high intensity proton beams.

  4. Nuclear design aspect of the Korean high intensity proton accelerator project

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Jonghwa; Song, Tae-Yung [Korea Atomic Energy Research Inst., Yusong, Taejon (Korea, Republic of)

    1998-11-01

    A plan to construct a high current proton accelerator has been proposed by KAERI. We are presenting the required nuclear design to support the project as well as a brief overview of the proposed proton accelerator. The target and core design is highlighted to show feasibility of incineration of minor actinides from the spent fuel of light water reactors. Radiation shielding and activation analyses are also important for the design and the license of the accelerator. (author)

  5. Development of high intensity linear accelerator for heavy ion inertial fusion driver

    Energy Technology Data Exchange (ETDEWEB)

    Lu, Liang, E-mail: luliang@riken.jp [Institute of Modern Physics, 509 Nanchang Road, Lanzhou 730000 (China); Riken Nishina Center for Accelerator-Based Science, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan); Hattori, Toshiyuki [National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba-shi 263-8555 (Japan); Hayashizaki, Noriyosu [Research Laboratory for Nuclear Reactors, Tokyo Institute of Technology, N1-25 2-12-1 O-okayama, Meguro-ku, Tokyo 152-8550 (Japan); Ishibashi, Takuya [High Energy Accelerator Research Organization, 1-1 Oho, Tsukuba, Ibaraki 305-0801 (Japan); Okamura, Masahiro [Brookhaven National Laboratory, Upton, NY 11973 (United States); Kashiwagi, Hirotsugu [Japan Atomic Energy Research Institute, 1233 Watanuki-machi, Takasaki, Gunma 370-1292 (Japan); Takeuchi, Takeshi [Accelerator Engineering Corporation, 301, 6-18-1 Konakadai, Inage-ku, Chiba 263-0043 (Japan); Zhao, Hongwei; He, Yuan [Institute of Modern Physics, 509 Nanchang Road, Lanzhou 730000 (China)

    2013-11-21

    In order to verify the direct plasma injection scheme (DPIS), an acceleration test was carried out in 2001 using a radio frequency quadrupole (RFQ) heavy ion linear accelerator (linac) and a CO{sub 2}-laser ion source (LIS) (Okamura et al., 2002) [1]. The accelerated carbon beam was observed successfully and the obtained current was 9.22 mA for C{sup 4+}. To confirm the capability of the DPIS, we succeeded in accelerating 60 mA carbon ions with the DPIS in 2004 (Okamura et al., 2004; Kashiwagi and Hattori, 2004) [2,3]. We have studied a multi-beam type RFQ with an interdigital-H (IH) cavity that has a power-efficient structure in the low energy region. We designed and manufactured a two-beam type RFQ linac as a prototype for the multi-beam type linac; the beam acceleration test of carbon beams showed that it successfully accelerated from 5 keV/u up to 60 keV/u with an output current of 108 mA (2×54 mA/channel) (Ishibashi et al., 2011) [4]. We believe that the acceleration techniques of DPIS and the multi-beam type IH-RFQ linac are technical breakthroughs for heavy-ion inertial confinement fusion (HIF). The conceptual design of the RF linac with these techniques for HIF is studied. New accelerator-systems using these techniques for the HIF basic experiment are being designed to accelerate 400 mA carbon ions using four-beam type IH-RFQ linacs with DPIS. A model with a four-beam acceleration cavity was designed and manufactured to establish the proof of principle (PoP) of the accelerator.

  6. A research plan based on high intensity proton accelerator Neutron Science Research Center

    Energy Technology Data Exchange (ETDEWEB)

    Mizumoto, Motoharu [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1997-03-01

    A plan called Neutron Science Research Center (NSRC) has been proposed in JAERI. The center is a complex composed of research facilities based on a proton linac with an energy of 1.5GeV and an average current of 10mA. The research facilities will consist of Thermal/Cold Neutron Facility, Neutron Irradiation Facility, Neutron Physics Facility, OMEGA/Nuclear Energy Facility, Spallation RI Beam Facility, Meson/Muon Facility and Medium Energy Experiment Facility, where high intensity proton beam and secondary particle beams such as neutron, pion, muon and unstable radio isotope (RI) beams generated from the proton beam will be utilized for innovative researches in the fields on nuclear engineering and basic sciences. (author)

  7. Beam Dynamics Studies and the Design, Fabrication and Testing of Superconducting Radiofrequency Cavity for High Intensity Proton Accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Saini, Arun [Univ. of Delhi, New Delhi (India)

    2012-03-01

    The application horizon of particle accelerators has been widening significantly in recent decades. Where large accelerators have traditionally been the tools of the trade for high-energy nuclear and particle physics, applications in the last decade have grown to include large-scale accelerators like synchrotron light sources and spallation neutron sources. Applications like generation of rare isotopes, transmutation of nuclear reactor waste, sub-critical nuclear power, generation of neutrino beams etc. are next area of investigation for accelerator scientific community all over the world. Such applications require high beam power in the range of few mega-watts (MW). One such high intensity proton beam facility is proposed at Fermilab, Batavia, US, named as Project-X. Project-X facility is based on H- linear accelerator (linac), which will operate in continuous wave (CW) mode and accelerate H- ion beam with average current of 1 mA from kinetic energy of 2.5 MeV to 3 GeV to deliver 3MW beam power. One of the most challenging tasks of the Project-X facility is to have a robust design of the CW linac which can provide high quality beam to several experiments simultaneously. Hence a careful design of linac is important to achieve this objective.

  8. Kinetic Modeling of Next-Generation High-Energy, High-Intensity Laser-Ion Accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Albright, Brian James [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Yin, Lin [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Stark, David James [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-02-06

    One of the long-standing problems in the community is the question of how we can model “next-generation” laser-ion acceleration in a computationally tractable way. A new particle tracking capability in the LANL VPIC kinetic plasma modeling code has enabled us to solve this long-standing problem

  9. Recent Progress in High Intensity Operation of the Fermilab Accelerator Complex

    Energy Technology Data Exchange (ETDEWEB)

    Convery, Mary E [Fermilab

    2016-10-05

    We report on the status of the Fermilab accelerator com-plex. Beam delivery to the neutrino experiments surpassed our goals for the past year. The Proton Improvement Plan is well underway with successful 15 Hz beam operation. Beam power of 700 kW to the NOvA experiment was demonstrated and will be routine in the next year. We are also preparing the Muon Campus to commission beam to the g-2 experiment.

  10. The R&D Works on the High Intensity Proton Linear Accelerator for Nuclear Waste Transmutation

    CERN Document Server

    Ito, N; Ino, H; Kawai, M; Kusano, J; Mizumoto, M; Murata, H; Oguri, H; Okumura, Y; Touchi, Y

    1996-01-01

    The R&D works of the 10MeV/10mA proton linear accelerator have been carried out for last four years. A high brightness hydrogen ion source, an RFQ and an RF power source have been developed and examined to achieve 2MeV proton beam. A DTL hot test model was also fabricated and a high power test has been carried out. The present status of the R&D works are described in this paper.

  11. Basic design of shield blocks for a spallation neutron source under the high-intensity proton accelerator project

    Energy Technology Data Exchange (ETDEWEB)

    Yoshida, Katsuhiko; Maekawa, Fujio; Takada, Hiroshi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    2003-03-01

    Under the JAERI-KEK High-Intensity Proton Accelerator Project (J-PARC), a spallation neutron source driven by a 3 GeV-1 MW proton beam is planed to be constructed as a main part of the Materials and Life Science Facility. Overall dimensions of a biological shield of the neutron source had been determined by evaluation of shielding performance by Monte Carlo calculations. This report describes results of design studies on an optimum dividing scheme in terms of cost and treatment and mechanical strength of shield blocks for the biological shield. As for mechanical strength, it was studied whether the shield blocks would be stable, fall down or move to a horizontal direction in case of an earthquake of seismic intensity of 5.5 (250 Gal) as an abnormal load. For ceiling shielding blocks being supported by both ends of the long blocks, maximum bending moment and an amount of maximum deflection of their center were evaluated. (author)

  12. The Summary for Optimization of the Annular Coupled Structure Accelerating Module Physical Design for High Intensity Hadron Linac

    CERN Document Server

    Paramonov, Valentin

    2013-01-01

    The normal conducting Annular Coupled Structure (ACS) is applied for 190-400 MeV part of high intensity proton linac for the J-PARC. The ACS operating frequency is 972 MHz. The J-PARC ACS is strongly based on the results of previous investigations, especially results of Japan Hadron Project (JHP) research program in KEK. However, the design was revised and optimized to meet the requirements of reliability, operation efficiency and cost reduction. The cells shape of accelerating cells was optimized in total energy range to have high shunt impedance value together with the careful matching with the decreased coupling cells. The design of the bridge coupler cells was optimized to simplify mass production and shape of RF input cell together with matching window were optimized for higher operational reliability. Collected and adjusted all together, these modifications result in the significant effect. The ACS module design doesn't lose to another possible accelerating structures in RF parameters and dimensions. Pr...

  13. 3-dimensional shielding design for a spallation neutron source facility in the high-intensity proton accelerator project

    Energy Technology Data Exchange (ETDEWEB)

    Tamura, Masaya; Maekawa, Fujio [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    2003-03-01

    Evaluation of shielding performance for a 1 MW spallation neutron source facility in the Materials and Life Science Facility being constructed in the High-Intensity Proton Accelerator Project (J-PARC) is important from a viewpoint of radiation safety and optimization of arrangement of components. This report describes evaluated results for the shielding performance with modeling three-dimensionally whole structural components including gaps between them in detail. A Monte Carlo calculation method with MCNPX2.2.6 code and LA-150 library was adopted. Streaming and void effects, optimization of shield for cost reduction and optimization of arrangement of structures such as shutters were investigated. The streaming effects were investigated quantitatively by changing the detailed structure of components and gap widths built into the calculation model. Horizontal required shield thicknesses were ranged from about 6.5 m to 7.5 m as a function of neutron beam line angles. A shutter mechanism for a horizontal neutron reflectometer that was directed downward was devised, and it was shown that the shielding performance of the shutter was acceptable. An optimal biological shield configuration was finally determined according to the calculated results. (author)

  14. Study on bulk shielding for a spallation neutron source facility in the high-intensity proton accelerator project

    CERN Document Server

    Maekawa, F; Takada, H; Teshigawara, M; Watanabe, N

    2002-01-01

    Under the JAERI-KEK High-Intensity Proton Accelerator Project, a spallation neutron source driven by a 3 GeV-1 MW proton beam is planed to be constructed in a main part of the Materials and Life Science Facility. This report describes results of a study on bulk shielding performance of a biological shield for the spallation neutron source by means of a Monte Carlo calculation method, that is important in terms of radiation safety and cost reduction. A shielding configuration was determined as a reference case by considering preliminary studies and interaction with other components, then shielding thickness that was required to achieve a target dose rate of 1 mu Sv/h was derived. Effects of calculation conditions such as shielding materials and dimensions on the shielding performance was investigated by changing those parameters. By taking all the results and design margins into account, a shielding configuration that was identified as the most appropriate was finally determined as follows. An iron shield regi...

  15. Investigation of Generation, Acceleration, Transport and Final Focusing of High-Intensity Heavy Ion Beams from Sources to Targets

    Energy Technology Data Exchange (ETDEWEB)

    Chiping Chen

    2006-10-26

    Under the auspices of the research grant, the Intense Beam Theoretical Research Goup at Massachusetts Institute of Technology's Plasma Science and Fusion Center made significant contributions in a number of important areas in the HIF and HEDP research, including: (a) Derivation of rms envelope equations and study of rms envelope dynamics for high-intensity heavy ion beams in a small-aperture AG focusing transport systems; (b) Identification of a new mechanism for chaotic particle motion, halo formation, and beam loss in high-intensity heavy ion beams in a small-aperture AG focusing systems; Development of elliptic beam theory; (d) Study of Physics Issues in the Neutralization Transport Experiment (NTX).

  16. Double ionization effect in electron accelerations by high-intensity laser pulse interaction with a neutral gas

    Science.gov (United States)

    Nandan Gupta, Devki

    2013-11-01

    We study the effect of laser-induced double-ionization of a helium gas (with inhomogeneous density profile) on vacuum electron acceleration. For enough laser intensity, helium gas can be found doubly ionized and it strengthens the divergence of the pulse. The double ionization of helium gas can defocus the laser pulse significantly, and electrons are accelerated by the front of the laser pulse in vacuum and then decelerated by the defocused trail part of the laser pulse. It is observed that the electrons experience a very low laser-intensity at the trailing part of the laser pulse. Hence, there is not much electron deceleration at the trailing part of the pulse. We found that the inhomogeneity of the neutral gas reduced the rate of tunnel ionization causing less defocusing of the laser pulse and thus the electron energy gain is reduced.

  17. Double ionization effect in electron accelerations by high-intensity laser pulse interaction with a neutral gas

    Directory of Open Access Journals (Sweden)

    Gupta Devki Nandan

    2013-11-01

    Full Text Available We study the effect of laser-induced double-ionization of a helium gas (with inhomogeneous density profile on vacuum electron acceleration. For enough laser intensity, helium gas can be found doubly ionized and it strengthens the divergence of the pulse. The double ionization of helium gas can defocus the laser pulse significantly, and electrons are accelerated by the front of the laser pulse in vacuum and then decelerated by the defocused trail part of the laser pulse. It is observed that the electrons experience a very low laser-intensity at the trailing part of the laser pulse. Hence, there is not much electron deceleration at the trailing part of the pulse. We found that the inhomogeneity of the neutral gas reduced the rate of tunnel ionization causing less defocusing of the laser pulse and thus the electron energy gain is reduced.

  18. Short and long term ionizing radiation effects on charge-coupled devices in radiation environment of high-intensity heavy ion accelerators

    Science.gov (United States)

    Belousov, A.; Mustafin, E.; Ensinger, W.

    2012-11-01

    Radiation effects on semiconductor devices is a topical issue for high-intensity accelerator projects. In particular it concerns Charge-Coupled Device (CCD) cameras, which are widely used for beam profile monitoring and surveillance in high radiation environment. One should have a clear idea of short and long term radiation effects on such devices. To study these effects, a CCD camera was placed in positions less than half meter away from beam loss point. Primary heavy ion beam of 0.95GeV/n Uranium was dumped into a thick aluminium target creating high fluences of secondary particles (e.g., gammas, neutrons, protons). Effects of these particles on CCD camera were scored with LabView based acquisition software. Monte Carlo calculations with FLUKA code were performed to obtain fluence distributions for different particles and make relevant comparisons. Long term total ionising dose effects are represented by dark current increase, which was scored throughout experiment. Instant radiation effects are represented by creation of charge in CCD cells by ionising particles. Relation of this charge to beam intensity was obtained for different camera positions and fluences within 5 orders of magnitude ranges. With high intensities this charge is so high that it may dramatically influence data obtained from CCD camera used in high radiation environment. The linearity of described above relation confirms linear response of CCD to ionizing radiation. It gives an opportunity to find a new application to CCD cameras as beam loss monitors (BLM).

  19. CAS Scientists Develop China's First RFQ Accelerator

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ With the support of the National Program on Key Basic Research Projects (dubbed the "973Program"), researchers from the CAS Institute of High Energy Physics (IHEP) have developed the first high-power Radio Frequency Quadrupole (RFQ) accelerator in China.

  20. Study and optimization of a LINAC drift tube for high intensity proton acceleration; Etude et optimisation d'un LINAC a tubes de glissement pour acceleration de forts courants de protons en continu

    Energy Technology Data Exchange (ETDEWEB)

    Bernaudin, P.E

    2002-09-01

    High intensity proton accelerators lead to specific problems related to the need to limit beam losses. The problem is more acute in the low energy part (up to 20 MeV) where the beam transport is the most difficult. The drift tube linac (DTL) remains the reference structure for energies of a few MeV to a few dozens MeV despite the arising of some new cavity types. This thesis purpose is to design such a DTL for a high intensity proton accelerator. Until now, no such continuous wave cavity has ever been operated. To ensure the viability of such an accelerator, a short four cells prototype is designed, built and tested under nominal RF conditions. This prototype is fully representative of a complete machine except for its length. The design complexity comes from the combination of RF electromagnetism, thermal exchanges, mechanics, ultra-vacuum engineering and manufacturing constraints. More specifically, the electromagnets alignment is a primary factor, and reliability, despite being usually of secondary importance in particles accelerator science, is here a major concern considering potential industrial applications of this machine. The prototype design includes the cavity itself, but also quadrupole electromagnets whose feasibility is a limiting factor, considering the very small space available to them. Two different magnet types and associated drift tubes are studied and manufactured, to be tested in the prototype cavity. The experimental part is focused on mechanical and thermal aspects. The electromagnetic properties of the cavity are also checked. As a conclusion of this thesis, technical and conceptual improvements as suggested by the manufacturing and experimental phases are presented, to be implemented in a complete cavity. (author)

  1. China to Further Accelerate Overseas Oil Operation

    Institute of Scientific and Technical Information of China (English)

    Zhang Wenhua

    2001-01-01

    @@ With China's national economy developing rapidly, the contradiction between oil supply and demand is increasing intense in the country. The growth of the domestic production has been lower than that of consumption since 1993.Reportedly, the oil consumption will rise at a rate of about 3.5 percent each year before 2010 while dependence on foreign oil resources will rise to 44 percent by 2010 from the current 20percent. It is an important issue for China's future economy to secure a long-term and stable oil supply. It is necessary to accelerate China's overseas oil operation because this issue is strategically related to whether the national economy can be kept growing continuously and healthfully.

  2. Development of high intensity ion sources for a Tandem-Electrostatic-Quadrupole facility for Accelerator-Based Boron Neutron Capture Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Bergueiro, J. [Gerencia de Investigacion y Aplicaciones, Comision Nacional de Energia Atomica (Argentina)] [CONICET, Buenos Aires (Argentina); Igarzabal, M.; Suarez Sandin, J.C. [Gerencia de Investigacion y Aplicaciones, Comision Nacional de Energia Atomica (Argentina); Somacal, H.R. [Gerencia de Investigacion y Aplicaciones, Comision Nacional de Energia Atomica (Argentina)] [Escuela de Ciencia y Tecnologia, Universidad Nacional de San Martin (Argentina); Thatar Vento, V. [Gerencia de Investigacion y Aplicaciones, Comision Nacional de Energia Atomica (Argentina)] [CONICET, Buenos Aires (Argentina); Huck, H.; Valda, A.A. [Gerencia de Investigacion y Aplicaciones, Comision Nacional de Energia Atomica (Argentina)] [Escuela de Ciencia y Tecnologia, Universidad Nacional de San Martin (Argentina); Repetto, M. [Gerencia de Investigacion y Aplicaciones, Comision Nacional de Energia Atomica (Argentina)

    2011-12-15

    Several ion sources have been developed and an ion source test stand has been mounted for the first stage of a Tandem-Electrostatic-Quadrupole facility For Accelerator-Based Boron Neutron Capture Therapy. A first source, designed, fabricated and tested is a dual chamber, filament driven and magnetically compressed volume plasma proton ion source. A 4 mA beam has been accelerated and transported into the suppressed Faraday cup. Extensive simulations of the sources have been performed using both 2D and 3D self-consistent codes.

  3. Demonstration of a high-intensity neutron source based on a liquid-lithium target for Accelerator based Boron Neutron Capture Therapy.

    Science.gov (United States)

    Halfon, S; Arenshtam, A; Kijel, D; Paul, M; Weissman, L; Berkovits, D; Eliyahu, I; Feinberg, G; Kreisel, A; Mardor, I; Shimel, G; Shor, A; Silverman, I; Tessler, M

    2015-12-01

    A free surface liquid-lithium jet target is operating routinely at Soreq Applied Research Accelerator Facility (SARAF), bombarded with a ~1.91 MeV, ~1.2 mA continuous-wave narrow proton beam. The experiments demonstrate the liquid lithium target (LiLiT) capability to constitute an intense source of epithermal neutrons, for Accelerator based Boron Neutron Capture Therapy (BNCT). The target dissipates extremely high ion beam power densities (>3 kW/cm(2), >0.5 MW/cm(3)) for long periods of time, while maintaining stable conditions and localized residual activity. LiLiT generates ~3×10(10) n/s, which is more than one order of magnitude larger than conventional (7)Li(p,n)-based near threshold neutron sources. A shield and moderator assembly for BNCT, with LiLiT irradiated with protons at 1.91 MeV, was designed based on Monte Carlo (MCNP) simulations of BNCT-doses produced in a phantom. According to these simulations it was found that a ~15 mA near threshold proton current will apply the therapeutic doses in ~1h treatment duration. According to our present results, such high current beams can be dissipated in a liquid-lithium target, hence the target design is readily applicable for accelerator-based BNCT.

  4. Development of a dedicated beam forming system for material and bioscience research with high intensity, small field electron beam of LILLYPUT 3 accelerator at Wroclaw Technology Park

    CERN Document Server

    Adrich, Przemysław; Wilk, Piotr; Chorowski, Maciej; Poliński, Jarosław; Bogdan, Piotr

    2016-01-01

    The primary use of the LILLYPUT 3 accelerator at the Nondestructive Testing Laboratory at Wroclaw Technology Park is X-ray radiography for nondestructive testing, including R&D of novel techniques for industrial and medical imaging. The scope of possible applications could be greatly extended by providing a system for irradiation with electron beam. The purpose of this work was to design such a system, especially for high dose rate, small field irradiations under cryogenic conditions for material and bioscience research. In this work, two possible solutions, based either on beam scanning or scattering and collimation, were studied and compared. It was found that under existing conditions efficiency of both systems would be comparable. The latter one was adopted due to its simplicity and much lower cost. The system design was optimized by means of detailed Monte Carlo modeling. The system is being currently fabricated at National Centre for Nuclear Research in \\'Swierk.

  5. Strong Radiation-Damping Effects in a Gamma-Ray Source Generated by the Interaction of a High-Intensity Laser with a Wakefield-Accelerated Electron Beam

    Science.gov (United States)

    Thomas, A. G. R.; Ridgers, C. P.; Bulanov, S. S.; Griffin, B. J.; Mangles, S. P. D.

    2012-10-01

    A number of theoretical calculations have studied the effect of radiation-reaction forces on radiation distributions in strong-field counterpropagating electron-beam-laser interactions, but could these effects—including quantum corrections—be observed in interactions with realistic bunches and focusing fields, as is hoped in a number of soon-to-be-proposed experiments? We present numerical calculations of the angularly resolved radiation spectrum from an electron bunch with parameters similar to those produced in laser-wakefield-acceleration experiments, interacting with an intense, ultrashort laser pulse. For our parameters, the effect of radiation damping on the angular distribution and energy distribution of photons is not easily discernible for a realistic moderate-emittance electron beam. However, experiments using such a counterpropagating beam-laser geometry should be able to measure these effects using current laser systems through measurement of the electron-beam properties. In addition, the brilliance of this source is very high, with peak spectral brilliance exceeding 1029photonss-1mm-2mrad-2(0.1%bandwidth)-1 with an approximately 2% conversion efficiency and with a peak energy of 10 MeV.

  6. Strong radiation damping effects in a gamma-ray source generated by the interaction of a high intensity laser with a wakefield accelerated electron beam

    Science.gov (United States)

    Thomas, Alexander; Ridgers, Christopher; Bulanov, Stepan; Griffin, Blake; Mangles, Stuart

    2012-10-01

    We present numerical calculations of the angularly resolved radiation spectrum from a relativistic electron beam interacting with an ultrashort laser pulse. These calculations include the effect of semi-classical radiation reaction forces including a Gaunt factor for synchrotron radiation. For a laser of 5x10^21 Wcm-2 intensity interacting with a 200 MeV electron beam with an emittance similar to that in laser wakefield acceleration experiments, radiation reaction does not produce a significant change in the angular and energy distribution of photons. However the effects of radiation reaction are clear when observing the electron beam properties. The result is that near-term experiments using such a counter-propagating beam-laser geometry should be able to measure the effects of quantum effects in radiation reaction. The calculations also show that the brilliance of this source is very high, with a peak spectral brilliance exceeding 10^29 photons,s-1mm-2mrad-2(0.1% bandwidth)-1 with approximately 2% efficiency and with a peak energy of 10 MeV.

  7. RELATIVISTIC (E > 0.6, > 2.0, AND > 4.0 MeV) ELECTRON ACCELERATION AT GEOSYNCHRONOUS ORBIT DURING HIGH-INTENSITY, LONG-DURATION, CONTINUOUS AE ACTIVITY (HILDCAA) EVENTS

    Energy Technology Data Exchange (ETDEWEB)

    Hajra, Rajkumar; Echer, Ezequiel; Gonzalez, Walter D. [Instituto Nacional de Pesquisas Espaciais (INPE), Av. dos Astronautas, 1758, São José dos Campos, São Paulo 12227-010 (Brazil); Tsurutani, Bruce T. [Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Drive Pasadena, Pasadena, CA 91109 (United States); Santolik, Ondrej, E-mail: rajkumarhajra@yahoo.co.in [Institute of Atmospheric Physics AS CR, Prague (Czech Republic)

    2015-01-20

    Radiation-belt relativistic (E > 0.6, > 2.0, and > 4.0 MeV) electron acceleration is studied for solar cycle 23 (1995-2008). High-intensity, long-duration, continuous AE activity (HILDCAA) events are considered as the basis of the analyses. All of the 35 HILDCAA events under study were found to be characterized by flux enhancements of magnetospheric relativistic electrons of all three energies compared to the pre-event flux levels. For the E > 2.0 MeV electron fluxes, enhancement of >50% occurred during 100% of HILDCAAs. Cluster-4 passes were examined for electromagnetic chorus waves in the 5 < L < 10 and 0 < MLT < 12 region when wave data were available. Fully 100% of these HILDCAA cases were associated with enhanced whistler-mode chorus waves. The enhancements of E > 0.6, > 2.0, and > 4.0 MeV electrons occurred ∼1.0 day, ∼1.5 days, and ∼2.5 days after the statistical HILDCAA onset, respectively. The statistical acceleration rates for the three energy ranges were ∼1.8 × 10{sup 5}, 2.2 × 10{sup 3}, and 1.0 × 10{sup 1} cm{sup –2} s{sup –1} sr{sup –1} d{sup –1}, respectively. The relativistic electron-decay timescales were determined to be ∼7.7, 5.5, and 4.0 days for the three energy ranges, respectively. The HILDCAAs were divided into short-duration (D ≤ 3 days) and long-duration (D > 3 days) events to study the dependence of relativistic electron variation on HILDCAA duration. For long-duration events, the flux enhancements during HILDCAAs with respect to pre-event fluxes were ∼290%, 520%, and 82% for E > 0.6, > 2.0, and > 4.0 MeV electrons, respectively. The enhancements were ∼250%, 400%, and 27% respectively, for short-duration events. The results are discussed with respect to the current understanding of radiation-belt dynamics.

  8. CW high intensity non-scaling FFAG proton drivers

    CERN Document Server

    Johnstone, C; Makino, K; Snopok, P

    2012-01-01

    Accelerators are playing increasingly important roles in basic science, technology, and medicine including nuclear power, industrial irradiation, material science, and neutrino production. Proton and light-ion accelerators in particular have many research, energy and medical applications, providing one of the most effective treatments for many types of cancer. Ultra high-intensity and high-energy (GeV) proton drivers are a critical technology for accelerator-driven sub-critical reactors (ADS) and many HEP programs (Muon Collider). These high-intensity GeV-range proton drivers are particularly challenging, encountering duty cycle and space-charge limits in the synchrotron and machine size concerns in the weaker-focusing cyclotrons; a 10-20 MW proton driver is not presently considered technically achievable with conventional re-circulating accelerators. One, as-yet, unexplored re-circulating accelerator, the Fixed-field Alternating Gradient, or FFAG, is an attractive alternative to the cyclotron. Its strong foc...

  9. LHC Report: reaching high intensity

    CERN Multimedia

    Jan Uythoven

    2015-01-01

    After both beams having been ramped to their full energy of 6.5 TeV, the last two weeks saw the beam commissioning process advancing on many fronts. An important milestone was achieved when operators succeeded in circulating a nominal-intensity bunch. During the operation, some sudden beam losses resulted in beam dumps at top energy, a problem that needed to be understood and resolved.   In 2015 the LHC will be circulating around 2800 bunches in each beam and each bunch will contain just over 1 x 1011 protons. Until a few days ago commissioning was taking place with single bunches of 5 x 109 protons. The first nominal bunch with an intensity of 1 x 1011 protons was injected on Tuesday, 21 April. In order to circulate such a high-intensity bunch safely, the whole protection system must be working correctly: collimators, which protect the aperture, are set at preliminary values known as coarse settings; all kicker magnets for injecting and extracting the beams are commissioned with beam an...

  10. Final Report on Institutional Computing Project s15_hilaserion, “Kinetic Modeling of Next-Generation High-Energy, High-Intensity Laser-Ion Accelerators as an Enabling Capability”

    Energy Technology Data Exchange (ETDEWEB)

    Albright, Brian James [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Yin, Lin [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Stark, David James [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-02-06

    This proposal sought of order 1M core-hours of Institutional Computing time intended to enable computing by a new LANL Postdoc (David Stark) working under LDRD ER project 20160472ER (PI: Lin Yin) on laser-ion acceleration. The project was “off-cycle,” initiating in June of 2016 with a postdoc hire.

  11. The R/D of high power proton accelerator technology in China

    Indian Academy of Sciences (India)

    Guan Xialing

    2002-12-01

    In China, a multipurpose verification system as a first phase of our ADS program consists of a low energy accelerator (150 MeV/3 mA proton LINAC) and a swimming pool light water subcritical reactor. In this paper the activities of HPPA technology related to ADS in China, which includes the intense proton ECR source, the RFQ accelerator and some other technology of HPPA, are described.

  12. High-intensity training in football.

    Science.gov (United States)

    Iaia, F Marcello; Rampinini, Ermanno; Bangsbo, Jens

    2009-09-01

    This article reviews the major physiological and performance effects of aerobic high-intensity and speed-endurance training in football, and provides insight on implementation of individual game-related physical training. Analysis and physiological measurements have revealed that modern football is highly energetically demanding, and the ability to perform repeated high-intensity work is of importance for the players. Furthermore, the most successful teams perform more high-intensity activities during a game when in possession of the ball. Hence, footballers need a high fitness level to cope with the physical demands of the game. Studies on football players have shown that 8 to 12 wk of aerobic high-intensity running training (> 85% HR(max)) leads to VO2(max) enhancement (5% to 11%), increased running economy (3% to 7%), and lower blood lactate accumulation during submaximal exercise, as well as improvements in the yo-yo intermittent recovery (YYIR) test performance (13%). Similar adaptations are observed when performing aerobic high-intensity training with small-sided games. Speed-endurance training has a positive effect on football-specific endurance, as shown by the marked improvements in the YYIR test (22% to 28%) and the ability to perform repeated sprints (approximately 2%). In conclusion, both aerobic and speed-endurance training can be used during the season to improve high-intensity intermittent exercise performance. The type and amount of training should be game related and specific to the technical, tactical, and physical demands imposed on each player.

  13. Proton Acceleration Drived by High-intensity Ultraviolet Laser

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    The generation of energetic protons from a solid thin-foil by the interactions of ultra-short and intense laser pulses is investigated in numerous experiments in the last decade. The energetic proton beams are promising candidates for proton fast ignitor (PFI)

  14. Research and application of electron accelerator in China

    Energy Technology Data Exchange (ETDEWEB)

    Zhan Wenlong; Liu Zhenghao [Chinese Academy of Sciences, Institute of Modern Physics, Lanzhou (China)

    2003-02-01

    There are more than 30 product lines of irradiation cross-linking wire and cable and shrinkable tube by EB in Chinese industry. Total of 3,000 KW power of EB, in which 40% coming from home made accelerator. Recently, about 450 KW electron accelerator is being manufactured and used in protection of environment that is removal of SO{sub 2} and NO{sub x} from flue gas. (author)

  15. High-Intensity, High Charge-State Heavy Ion Sources

    CERN Document Server

    Alessi, J

    2004-01-01

    There are many accelerator applications for high intensity heavy ion sources, with recent needs including dc beams for RIA, and pulsed beams for injection into synchrotrons such as RHIC and LHC. The present status of sources producing high currents of high charge state heavy ions will be reviewed. These sources include ECR, EBIS, and Laser ion sources. The benefits and limitations for these type sources will be described, for both dc and pulsed applications. Possible future improvements in these type sources will also be discussed.

  16. High Intensity Interval Training: New Insights

    Institute of Scientific and Technical Information of China (English)

    Martin J.Gibala

    2008-01-01

    @@ KEY POINTS ·High-intensity interval training(HIT)is characterized by repeated sessions of relatively brief,intermittent exercise.often performed with an“a11 out”effort or at an intensity close to that which elicits peak oxygen uptake(i.e.,≥90%of VO2 peak).

  17. High Intensity Exercise in Multiple Sclerosis

    DEFF Research Database (Denmark)

    Wens, Inez; Dalgas, Ulrik; Vandenabeele, Frank

    2015-01-01

    Introduction Low-to-moderate intensity exercise improves muscle contractile properties and endurance capacity in multiple sclerosis (MS). The impact of high intensity exercise remains unknown. Methods Thirty-four MS patients were randomized into a sedentary control group (SED, n = 11) and 2...

  18. Study on Radiation Field Caused by Proton Beam Loss in High Intensity Heavy-ion Accelerator%强流重离子加速器中由于质子束流损失引起的次级辐射场计算研究

    Institute of Scientific and Technical Information of China (English)

    庞成果; 苏有武; 徐俊奎; 李武元; 姚泽恩

    2015-01-01

    The second radiation field outside the vacuum tube caused by proton beam loss in high intensity heavy‐ion accelerator facility (HIAF) with Monte Carlo method was calculated .The energy of proton beam is within 50 MeV to 12 GeV .The basic problems such as second particle yield ,energy spectrum and angular distribution were also discussed .T hese results are beneficial to selecting the detector type and its location and determining its dynamic range for beam loss detector ,as well as to building the beam loss monitor system .Furthermore ,they are meaningful in some way for the radia‐tion protection of accelerator .%本文利用蒙特卡罗方法计算了强流重离子加速器中质子能量在50 M eV~12 GeV能量范围内由于束流损失引起的真空管壁外的次级辐射场,分别就次级粒子的产额、能谱及角分布等方面进行了基本研究。本文的研究结果在束流损失探测器的选择、安装位置以及动态范围的确定上有着重要的参考价值,对于束流损失监测系统的建立有着极为重要的意义。同时,对于加速器的辐射防护问题也有一定的参考价值。

  19. The high intensity neutron source FRANZ

    CERN Document Server

    Lederer, Claudia

    2014-01-01

    The Frankfurt neutron source of Stern Gerlach Zentrum FRANZ is currently under construction at the University of Frankfurt. At FRANZ, a high intensity neutron beam in the keV energy region will be produced by bombarding a $^7$Li target with a proton beam of several mA. These unprecedented high neutron fluxes will allow a number of neutron induced cross section measurements for the first time. Measurements can be performed by the time-of-flight and by the activation technique.

  20. Cryogenic semiconductor high-intensity radiation monitors

    CERN Document Server

    Palmieri, V G; Borer, K; Casagrande, L; Da Vià, C; Devine, S R H; Dezillie, B; Esposito, A; Granata, V; Hauler, F; Jungermann, L; Li, Z; Lourenço, C; Niinikoski, T O; O'Shea, V

    2003-01-01

    This paper describes a novel technique to monitor high-intensity particle beams by means of a semiconductor detector. It consists of cooling a semiconductor detector down to cryogenic temperature to suppress the thermally generated leakage current and to precisely measure the integrated ionization signal. It will be shown that such a device provides very good linearity and a dynamic range wider than is possible with existing techniques. Moreover, thanks to the Lazarus effect, extreme radiation hardness can be achieved providing in turn absolute intensity measurements against precise calibration of the device at low beam flux.

  1. A transparent vacuum window for high-intensity pulsed beams

    CERN Document Server

    Monteil, M; Veness, R

    2011-01-01

    The HiRadMat (High-Radiation to Materials) facility Ill will allow testing of accelerator components, in particular those of the Large Hadron Collider (LHC) at CERN, under the impact of high-intensity pulsed beams. To reach this intensity range, the beam will be focused on a focal point where the target to be tested is located. A 60 mm aperture vacuum window will separate the vacuum of the beam line which is kept under high vacuum 10(-8) mbar, from the test area which is at atmospheric pressure. This window has to resist collapse due to beam passage. The high-intensity of the beam means that typical materials used for standard vacuum windows (such as stainless steel, aluminium and titanium alloy) cannot endure the energy deposition induced by the beam passage. Therefore, a vacuum window has been designed to maintain the differential pressure whilst resisting collapse due to the beam impact on the window. In this paper, we will present calculations of the energy transfer from beam to window, the design of the ...

  2. High intensity SRF proton linac workshop (vugraphs)

    Energy Technology Data Exchange (ETDEWEB)

    Rusnak, B.A.

    1995-11-01

    The meeting is divided into four sections. The first section is the general introduction and included opening remarks and an overview of APT (accelerator product of tritium). The second section contains vugraphs from the cavity-structures working group. The third section is comprised of vugraphs from the couplers and rf working group. And the fourth section contains vugraphs of the system integration group.

  3. High-Intensity Synchrotron Radiation Effects

    CERN Document Server

    Suetsugu, Y

    2016-01-01

    Various effects of intense synchrotron radiation on the performance of particle accelerators, especially for storage rings, are discussed. Following a brief introduction to synchrotron radiation, the basic concepts of heat load, gas load, electron emission, and the countermeasures against these effects are discussed.

  4. High intensity specular reflectometry - first experiments

    CERN Document Server

    Stahn, J; Panzner, T

    2011-01-01

    Selene is the attempt to implement a new scheme for high-intensity specular reflectometry. Instead of a highly collimated beam one uses a convergent beam covering a large angular range. The angular resolution is then performed by a position-sensitive detector. Off-specular scattering in this set-up leads to some background, but for screening of wide parameter ranges (e.g. temperature, electric and magnetic fields) the intensity gain of at least one order of magnitude is essential. If necessary, the high precession measurements (even with off-specular components) then are performed with the conventional set-up. The heart of this new set-up is an elliptically focusing guide element of 2\\,m length. Though this guide is optimised for the use on the TOF reflectometer Amor at SINQ, it can be used as stand-alone device to check the possible application also for other neutron scattering techniques. The first measurements on AMOR confirmed the general concept and the various operation modes. A draw-back occurred due t...

  5. High intensity neutrino oscillation facilities in Europe

    Energy Technology Data Exchange (ETDEWEB)

    Edgecock, T. R.; Caretta, O.; Davenne, T.; Densam, C.; Fitton, M.; Kelliher, D.; Loveridge, P.; Machida, S.; Prior, C.; Rogers, C.; Rooney, M.; Thomason, J.; Wilcox, D.; Wildner, E.; Efthymiopoulos, I.; Garoby, R.; Gilardoni, S.; Hansen, C.; Benedetto, E.; Jensen, E.; Kosmicki, A.; Martini, M.; Osborne, J.; Prior, G.; Stora, T.; Melo Mendonca, T.; Vlachoudis, V.; Waaijer, C.; Cupial, P.; Chancé, A.; Longhin, A.; Payet, J.; Zito, M.; Baussan, E.; Bobeth, C.; Bouquerel, E.; Dracos, M.; Gaudiot, G.; Lepers, B.; Osswald, F.; Poussot, P.; Vassilopoulos, N.; Wurtz, J.; Zeter, V.; Bielski, J.; Kozien, M.; Lacny, L.; Skoczen, B.; Szybinski, B.; Ustrycka, A.; Wroblewski, A.; Marie-Jeanne, M.; Balint, P.; Fourel, C.; Giraud, J.; Jacob, J.; Lamy, T.; Latrasse, L.; Sortais, P.; Thuillier, T.; Mitrofanov, S.; Loiselet, M.; Keutgen, Th.; Delbar, Th.; Debray, F.; Trophine, C.; Veys, S.; Daversin, C.; Zorin, V.; Izotov, I.; Skalyga, V.; Burt, G.; Dexter, A. C.; Kravchuk, V. L.; Marchi, T.; Cinausero, M.; Gramegna, F.; De Angelis, G.; Prete, G.; Collazuol, G.; Laveder, M.; Mazzocco, M.; Mezzetto, M.; Signorini, C.; Vardaci, E.; Di Nitto, A.; Brondi, A.; La Rana, G.; Migliozzi, P.; Moro, R.; Palladino, V.; Gelli, N.; Berkovits, D.; Hass, M.; Hirsh, T. Y.; Schaumann, M.; Stahl, A.; Wehner, J.; Bross, A.; Kopp, J.; Neuffer, D.; Wands, R.; Bayes, R.; Laing, A.; Soler, P.; Agarwalla, S. K.; Cervera Villanueva, A.; Donini, A.; Ghosh, T.; Gómez Cadenas, J. J.; Hernández, P.; Martín-Albo, J.; Mena, O.; Burguet-Castell, J.; Agostino, L.; Buizza-Avanzini, M.; Marafini, M.; Patzak, T.; Tonazzo, A.; Duchesneau, D.; Mosca, L.; Bogomilov, M.; Karadzhov, Y.; Matev, R.; Tsenov, R.; Akhmedov, E.; Blennow, M.; Lindner, M.; Schwetz, T.; Fernández Martinez, E.; Maltoni, M.; Menéndez, J.; Giunti, C.; González García, M. C.; Salvado, J.; Coloma, P.; Huber, P.; Li, T.; López Pavón, J.; Orme, C.; Pascoli, S.; Meloni, D.; Tang, J.; Winter, W.; Ohlsson, T.; Zhang, H.; Scotto-Lavina, L.; Terranova, F.; Bonesini, M.; Tortora, L.; Alekou, A.; Aslaninejad, M.; Bontoiu, C.; Kurup, A.; Jenner, L. J.; Long, K.; Pasternak, J.; Pozimski, J.; Back, J. J.; Harrison, P.; Beard, K.; Bogacz, A.; Berg, J. S.; Stratakis, D.; Witte, H.; Snopok, P.; Bliss, N.; Cordwell, M.; Moss, A.; Pattalwar, S.; Apollonio, M.

    2013-02-01

    The EUROnu project has studied three possible options for future, high intensity neutrino oscillation facilities in Europe. The first is a Super Beam, in which the neutrinos come from the decay of pions created by bombarding targets with a 4 MW proton beam from the CERN High Power Superconducting Proton Linac. The far detector for this facility is the 500 kt MEMPHYS water Cherenkov, located in the Fr\\'ejus tunnel. The second facility is the Neutrino Factory, in which the neutrinos come from the decay of {\\mu}+ and {\\mu}- beams in a storage ring. The far detector in this case is a 100 kt Magnetised Iron Neutrino Detector at a baseline of 2000 km. The third option is a Beta Beam, in which the neutrinos come from the decay of beta emitting isotopes, in particular 6He and 18Ne, also stored in a ring. The far detector is also the MEMPHYS detector in the Fr\\'ejus tunnel. EUROnu has undertaken conceptual designs of these facilities and studied the performance of the detectors. Based on this, it has determined the physics reach of each facility, in particular for the measurement of CP violation in the lepton sector, and estimated the cost of construction. These have demonstrated that the best facility to build is the Neutrino Factory. However, if a powerful proton driver is constructed for another purpose or if the MEMPHYS detector is built for astroparticle physics, the Super Beam also becomes very attractive.

  6. High intensity neutrino oscillation facilities in Europe

    CERN Document Server

    Edgecock, T R; Davenne, T; Densham, C; Fitton, M; Kelliher, D; Loveridge, P; Machida, S; Prior, C; Rogers, C; Rooney, M; Thomason, J; Wilcox, D; Wildner, E; Efthymiopoulos, I; Garoby, R; Gilardoni, S; Hansen, C; Benedetto, E; Jensen, E; Kosmicki, A; Martini, M; Osborne, J; Prior, G; Stora, T; Melo-Mendonca, T; Vlachoudis, V; Waaijer, C; Cupial, P; Chancé, A; Longhin, A; Payet, J; Zito, M; Baussan, E; Bobeth, C; Bouquerel, E; Dracos, M; Gaudiot, G; Lepers, B; Osswald, F; Poussot, P; Vassilopoulos, N; Wurtz, J; Zeter, V; Bielski, J; Kozien, M; Lacny, L; Skoczen, B; Szybinski, B; Ustrycka, A; Wroblewski, A; Marie-Jeanne, M; Balint, P; Fourel, C; Giraud, J; Jacob, J; Lamy, T; Latrasse, L; Sortais, P; Thuillier, T; Mitrofanov, S; Loiselet, M; Keutgen, Th; Delbar, Th; Debray, F; Trophine, C; Veys, S; Daversin, C; Zorin, V; Izotov, I; Skalyga, V; Burt, G; Dexter, A C; Kravchuk, V L; Marchi, T; Cinausero, M; Gramegna, F; De Angelis, G; Prete, G; Collazuol, G; Laveder, M; Mazzocco, M; Mezzetto, M; Signorini, C; Vardaci, E; Di Nitto, A; Brondi, A; La Rana, G; Migliozzi, P; Moro, R; Palladino, V; Gelli, N; Berkovits, D; Hass, M; Hirsh, T Y; Schaumann, M; Stahl, A; Wehner, J; Bross, A; Kopp, J; Neuffer, D; Wands, R; Bayes, R; Laing, A; Soler, P; Agarwalla, S K; Villanueva, A Cervera; Donini, A; Ghosh, T; Cadenas, J J Gómez; Hernández, P; Martín-Albo, J; Mena, O; Burguet-Castell, J; Agostino, L; Buizza-Avanzini, M; Marafini, M; Patzak, T; Tonazzo, A; Duchesneau, D; Mosca, L; Bogomilov, M; Karadzhov, Y; Matev, R; Tsenov, R; Akhmedov, E; Blennow, M; Lindner, M; Schwetz, T; Martinez, E Fernández; Maltoni, M; Menéndez, J; Giunti, C; García, M C González; Salvado, J; Coloma, P; Huber, P; Li, T; López-Pavón, J; Orme, C; Pascoli, S; Meloni, D; Tang, J; Winter, W; Ohlsson, T; Zhang, H; Scotto-Lavina, L; Terranova, F; Bonesini, M; Tortora, L; Alekou, A; Aslaninejad, M; Bontoiu, C; Kurup, A; Jenner, L J; Long, K; Pasternak, J; Pozimski, J; Back, J J; Harrison, P; Beard, K; Bogacz, A; Berg, J S; Stratakis, D; Witte, H; Snopok, P; Bliss, N; Cordwell, M; Moss, A; Pattalwar, S; Apollonio, M

    2013-01-01

    The EUROnu project has studied three possible options for future, high intensity neutrino oscillation facilities in Europe. The first is a Super Beam, in which the neutrinos come from the decay of pions created by bombarding targets with a 4 MW proton beam from the CERN High Power Superconducting Proton Linac. The far detector for this facility is the 500 kt MEMPHYS water Cherenkov, located in the Fr\\'ejus tunnel. The second facility is the Neutrino Factory, in which the neutrinos come from the decay of {\\mu}+ and {\\mu}- beams in a storage ring. The far detector in this case is a 100 kt Magnetised Iron Neutrino Detector at a baseline of 2000 km. The third option is a Beta Beam, in which the neutrinos come from the decay of beta emitting isotopes, in particular 6He and 18Ne, also stored in a ring. The far detector is also the MEMPHYS detector in the Fr\\'ejus tunnel. EUROnu has undertaken conceptual designs of these facilities and studied the performance of the detectors. Based on this, it has determined the ph...

  7. High-intensity sweeteners and energy balance.

    Science.gov (United States)

    Swithers, Susan E; Martin, Ashley A; Davidson, Terry L

    2010-04-26

    Recent epidemiological evidence points to a link between a variety of negative health outcomes (e.g. metabolic syndrome, diabetes and cardiovascular disease) and the consumption of both calorically sweetened beverages and beverages sweetened with high-intensity, non-caloric sweeteners. Research on the possibility that non-nutritive sweeteners promote food intake, body weight gain, and metabolic disorders has been hindered by the lack of a physiologically-relevant model that describes the mechanistic basis for these outcomes. We have suggested that based on Pavlovian conditioning principles, consumption of non-nutritive sweeteners could result in sweet tastes no longer serving as consistent predictors of nutritive postingestive consequences. This dissociation between the sweet taste cues and the caloric consequences could lead to a decrease in the ability of sweet tastes to evoke physiological responses that serve to regulate energy balance. Using a rodent model, we have found that intake of foods or fluids containing non-nutritive sweeteners was accompanied by increased food intake, body weight gain, accumulation of body fat, and weaker caloric compensation, compared to consumption of foods and fluids containing glucose. Our research also provided evidence consistent with the hypothesis that these effects of consuming saccharin may be associated with a decrement in the ability of sweet taste to evoke thermic responses, and perhaps other physiological, cephalic phase, reflexes that are thought to help maintain energy balance.

  8. Ion source choices - an h- source for the high intensity neutrino source

    Energy Technology Data Exchange (ETDEWEB)

    Moehs, Douglas P.; /Fermilab; Welton, Robert F.; /SNS Project, Oak Ridge; Stockli, Martin P.; Peters, Jens; /DESY; Alessi, James; /Brookhaven

    2006-08-01

    The High Intensity Neutrino Source (HINS) program at Fermilab (formerly the Proton Driver) aims to develop a multi-mission linear accelerator (LINAC) capable of accelerate H{sup -} ions to 8 GeV. This paper touches on the ion source requirements for the HINS and discusses long pulse length testing of three ion sources which appear to have the capability of meeting these requirements.

  9. Longitudinal tracking studies for a high intensity proton synchrotron

    Energy Technology Data Exchange (ETDEWEB)

    Lessner, E.; Cho, Y.; Harkay, K.; Symon, K. [Argonne National Laboratory, 9700 Cass Ave., Argonne, Illinois 60439 (United States)

    1996-06-01

    Results from longitudinal tracking studies for a high intensity proton synchrotron designed for a 1-MW spallation source are presented. The machine delivers a proton beam of 0.5 mA time-averaged current at a repetition rate of 30 Hz. The accelerator is designed to have radiation levels that allow hands-on-maintenance. However, the high beam intensity causes strong space charge fields whose effects may lead to particle loss and longitudinal instabilities. The space charge fields modify the particle distribution, distort the stable bucket area and reduce the rf linear restoring force. Tracking simulations were conducted to analyze the space charge effects on the dynamics of the injection and acceleration processes and means to circumvent them. The tracking studies led to the establishment of the injected beam parameters and rf voltage program that minimized beam loss and longitudinal instabilities. Similar studies for a 10-GeV synchrotron that uses the 2-GeV synchrotron as its injector are also discussed. {copyright} {ital 1996 American Institute of Physics.}

  10. Relativistic electron mirrors from high intensity laser nanofoil interactions

    Energy Technology Data Exchange (ETDEWEB)

    Kiefer, Daniel

    2012-12-21

    The reflection of a laser pulse from a mirror moving close to the speed of light could in principle create an X-ray pulse with unprecedented high brightness owing to the increase in photon energy and accompanying temporal compression by a factor of 4γ{sup 2}, where γ is the Lorentz factor of the mirror. While this scheme is theoretically intriguingly simple and was first discussed by A. Einstein more than a century ago, the generation of a relativistic structure which acts as a mirror is demanding in many different aspects. Recently, the interaction of a high intensity laser pulse with a nanometer thin foil has raised great interest as it promises the creation of a dense, attosecond short, relativistic electron bunch capable of forming a mirror structure that scatters counter-propagating light coherently and shifts its frequency to higher photon energies. However, so far, this novel concept has been discussed only in theoretical studies using highly idealized interaction parameters. This thesis investigates the generation of a relativistic electron mirror from a nanometer foil with current state-of-the-art high intensity laser pulses and demonstrates for the first time the reflection from those structures in an experiment. To achieve this result, the electron acceleration from high intensity laser nanometer foil interactions was studied in a series of experiments using three inherently different high power laser systems and free-standing foils as thin as 3nm. A drastic increase in the electron energies was observed when reducing the target thickness from the micrometer to the nanometer scale. Quasi-monoenergetic electron beams were measured for the first time from ultrathin (≤5nm) foils, reaching energies up to ∝35MeV. The acceleration process was studied in simulations well-adapted to the experiments, indicating the transition from plasma to free electron dynamics as the target thickness is reduced to the few nanometer range. The experience gained from those

  11. Enhancement of High-Intensity Focused Ultrasound Heating by Short-Pulse Generated Cavitation

    Directory of Open Access Journals (Sweden)

    Shin Yoshizawa

    2017-03-01

    Full Text Available A target tissue can be thermally coagulated in high-intensity focused ultrasound (HIFU treatment noninvasively. HIFU thermal treatments have been clinically applied to various solid tumors. One of the problems in HIFU treatments is a long treatment time. Acoustically driven microbubbles can accelerate the ultrasonic heating, resulting in the significant reduction of the treatment time. In this paper, a method named “trigger HIFU exposure” which employs cavitation microbubbles is introduced and its results are reviewed. A trigger HIFU sequence consists of high-intensity short pulses followed by moderate-intensity long bursts. Cavitation bubbles induced in a multiple focal regions by rapidly scanning the focus of high-intensity pulses enhanced the temperature increase significantly and produced a large coagulation region with high efficiency.

  12. Bunching high intensity proton beams with a CH-DTL

    Energy Technology Data Exchange (ETDEWEB)

    Schwarz, Malte; Claessens, Christine; Heilmann, Manuel; Hinrichs, Ole; Koser, Daniel; Meusel, Oliver; Noll, Daniel; Podlech, Holger; Ratzinger, Ulrich; Seibel, Anja [Institut fuer Angewandte Physik, Goethe-Universitaet Frankfurt am Main (Germany)

    2014-07-01

    The Frankfurt Neutron Source at the Stern-Gerlach-Zentrum (FRANZ) will provide ultra short neutron pulses at high intensities and repetition rates. The facility is under construction with an expected first beam by the end of 2014. A 5-Gap CH rebuncher is installed behind a coupled RFQ/IH-DTL combination at the end of the LINAC section between two magnetic quadrupole triplets. It will be used for varying the final energy between 1.8 and 2.2 MeV, as well as for focusing the proton beam bunch longitudinally, to compensate RF defocusing effects and huge space charge forces at currents up to 200 mA at the final stage of extension. Therefore high current beam dynamic simulations are in progress. They include benchmarking of different beam dynamic codes like LORASR, TraceWin and Bender (a new PIC tracking code developed at IAP), as well as validating the results by measurements. Detailed error tolerance studies, thermal simulations and examination of multipole field impact, due to the cavity geometry, are also done. Furthermore, this CH rebuncher serves as prototype for CH cavity operation at MYRRHA (Belgium), an Accelerator Driven System (ADS) for transmutation of high level nuclear waste. After copper-plating the cavity, RF conditioning will start in spring 2014.

  13. High Intensity Focused Ultrasound Tumor Therapy System and Its Application

    Science.gov (United States)

    Sun, Fucheng; He, Ye; Li, Rui

    2007-05-01

    At the end of last century, a High Intensity Focused Ultrasound (HIFU) tumor therapy system was successfully developed and manufactured in China, which has been already applied to clinical therapy. This article aims to discuss the HIFU therapy system and its application. Detailed research includes the following: power amplifiers for high-power ultrasound, ultrasound transducers with large apertures, accurate 3-D mechanical drives, a software control system (both high-voltage control and low-voltage control), and the B-mode ultrasonic diagnostic equipment used for treatment monitoring. Research on the dosage of ultrasound required for tumour therapy in multiple human cases has made it possible to relate a dosage formula, presented in this paper, to other significant parameters such as the volume of thermal tumor solidification, the acoustic intensity (I), and the ultrasound emission time (tn). Moreover, the HIFU therapy system can be applied to the clinical treatment of both benign and malignant tumors in the pelvic and abdominal cavity, such as uterine fibroids, liver cancer and pancreatic carcinoma.

  14. Seismicity acceleration model and its application to several earthquake regions in China

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    With the theory of subcritical crack growth, we can deduce the fundamental equation of regional seismicity acceleration model. Applying this model to intraplate earthquake regions, we select three earthquake subplates: North China Subplate, Chuan-Dian Block and Xinjiang Subplate, and divide the three subplates into seven researched regions by the difference of seismicity and tectonic conditions. With the modified equation given by Sornette and Sammis (1995), we analysis the seismicity of each region. To those strong earthquakes already occurred in these region, the model can give close fitting of magnitude and occurrence time, and the result in this article indicates that the seismicity acceleration model can also be used for describing the seismicity of intraplate. In the article, we give the magnitude and occurrence time of possible strong earthquakes in Shanxi, Ordos, Bole-Tuokexun, Ayinke-Wuqia earthquake regions. In the same subplate or block, the earthquake periods for each earthquake region are similar in time interval. The constant αin model can be used to describe the intensity of regional seismicity, and for the Chinese Mainland, α is 0.4 generally. To the seismicity in Taiwan and other regions with complex tectonic conditions, the model does not fit well at present.

  15. High intensity ultrasound transducer used in gene transfection

    Science.gov (United States)

    Morrison, Kyle P.; Keilman, George W.; Noble, Misty L.; Brayman, Andrew A.; Miao, Carol H.

    2012-11-01

    This paper describes a novel therapeutic high intensity non-focused ultrasound (HIU) transducer designed with uniform pressure distribution to aid in accelerated gene transfer in large animal liver tissues in vivo. The underlying HIU transducer was used to initiate homogeneous cavitation throughout the tissue while delivering up to 2.7 MPa at 1.1 MHz across its radiating surface. The HIU transducer was built into a 6 cm diameter x 1.3 cm tall housing ergonomically designed to avoid collateral damage to the surrounding anatomy during dynamic motion. The ultrasound (US) radiation was applied in a 'paintbrush-like' manner to the surface of the liver. The layers and geometry of the transducer were carefully selected to maximize the active diameter (5.74 cm), maximize the electrical to acoustic conversion efficiency (85%) to achieve 2.7 MPa of peak negative pressure, maximize the frequency operating band at the fundamental resonance to within a power transfer delta of 1 dB, and reduce the pressure delta to within 2 dB across the radiating surface. For maximum peak voltage into the transducer, a high performance piezoceramic was chosen and a DC bias circuit was built integral to the system. An apodized two element annular pattern was made from a single piezoceramic element, resulting in significant pressure uniformity enhancement. In addition to using apodization for pressure uniformity, a proprietary multi-layered structure was used to improve efficiency while sustaining an operating band from 900 kHz to 1.3 MHz. The resultant operating band allowed for dithering techniques using frequency modulation. The underlying HIU transducer for use in large animals enhances gene expression up to 6300-fold.

  16. Concept for a new high resolution high intensity diffractometer

    Energy Technology Data Exchange (ETDEWEB)

    Stuhr, U. [Paul Scherrer Inst. (PSI), Villigen (Switzerland)

    1997-09-01

    A concept of a new time-of-flight powder-diffractometer for a thermal neutral beam tube at SINQ is presented. The design of the instrument optimises the contradictory conditions of high intensity and high resolution. The high intensity is achieved by using many neutron pulses simultaneously. By analysing the time-angle-pattern of the detected neutrons an assignment of the neutrons to a single pulse is possible. (author) 3 figs., tab., refs.

  17. Effect of high intensity ultrasound on the allergenicity of shrimp

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    The tropomyosin fraction of shrimp proteins is potentially responsible for allergic reaction in individuals with genetic predisposition to allergy. However, there are no efficient and safe methods to reduce its allergenicity. High intensity ultrasound is known to change the structure of proteins. This study is aimed at assessing high intensity ultrasound's effect on the allergenicity of shrimp allergen. Shrimp and purified shrimp allergen were treated with high intensity ultrasound for 30~180 min. Extracts of treated samples were analyzed by enzyme-linked immunosorbent assay (ELISA) with pool serum of shrimp allergy patients and polyclonal anti-allergen antibodies and by immunoblotting after polyacrylamide gel electrophoresis. Shrimp treated with high intensity ultrasound showed a decrease in allergenicity measured with ELISA. A linear relationship between the immune response induced by treated shrimp allergen and the applied treatment time was observed. The decrease in allergenicity was confirmed by immunoblot assays with shrimp allergic patients serum. Allergenicity of shrimp allergen extracted from treated shrimp was higher than that of purified shrimp allergen with the same treatment time. Gel-filtration HPLC was applied for analysis of shrimp allergen after treatment with high intensity ultrasound. Some fractions were appeared with increasing treatment time. The results suggested that high intensity ultrasound could be used to reduce the allergenicity of shrimp.

  18. Repeated high-intensity exercise in professional rugby union.

    Science.gov (United States)

    Austin, Damien; Gabbett, Tim; Jenkins, David

    2011-07-01

    The aim of the present study was to describe the frequency, duration, and nature of repeated high-intensity exercise in Super 14 rugby union. Time-motion analysis was used during seven competition matches over the 2008 and 2009 Super 14 seasons; five players from each of four positional groups (front row forwards, back row forwards, inside backs, and outside backs) were assessed (20 players in total). A repeated high-intensity exercise bout was considered to involve three or more sprints, and/or tackles and/or scrum/ruck/maul activities within 21 s during the same passage of play. The range of repeated high-intensity exercise bouts for each group in a match was as follows: 11-18 for front row forwards, 11-21 for back row forwards, 13-18 for inside backs, and 2-11 for outside backs. The durations of the most intense repeated high-intensity exercise bouts for each position ranged from 53 s to 165 s and the minimum recovery periods between repeated high-intensity exercise bouts ranged from 25 s for the back row forwards to 64 s for the front row forwards. The present results show that repeated high-intensity exercise bouts vary in duration and activities relative to position but all players in a game will average at least 10 changes in activity in the most demanding bouts and complete at least one tackle and two sprints. The most intense periods of activity are likely to last as long as 120 s and as little as 25 s recovery may separate consecutive repeated high-intensity exercise bouts. The present findings can be used by coaches to prepare their players for the most demanding passages of play likely to be experienced in elite rugby union.

  19. Beam Dynamics Studies for High-Intensity Beams in the CERN Proton Synchrotron

    CERN Document Server

    AUTHOR|(CDS)2082016; Benedikt, Michael

    With the discovery of the Higgs boson, the existence of the last missing piece of the Standard Model of particle physics (SM) was confirmed. However, even though very elegant, this theory is unable to explain, for example, the generation of neutrino masses, nor does it account for dark energy or dark matter. To shed light on some of these open questions, research in fundamental particle physics pursues two complimentary approaches. On the one hand, particle colliders working at the high-energy frontier, such as the Large Hadron Collider (LHC) at the European Organization for Nuclear Research (CERN), located in Geneva, Switzerland, are utilized to investigate the fundamental laws of nature. Alternatively, fixed target facilities require high-intensity beams to create a large flux of secondary particles to investigate, for example, rare particle decay processes, or to create neutrino beams. This thesis investigates limitations arising during the acceleration of high-intensity beams at the CERN Proton Synchrotro...

  20. Human activity accelerating the rapid desertification of the Mu Us Sandy Lands, North China

    Science.gov (United States)

    Miao, Yunfa; Jin, Heling; Cui, Jianxin

    2016-03-01

    Over the past several thousand years, arid and semiarid China has experienced a series of asynchronous desertification events in its semiarid sandy and desert regions, but the precise identification of the driving forces of such events has remained elusive. In this paper we identify two rapid desertification events (RDEs) at ~4.6 ± 0.2 ka BP and ~3.3 ± 0.2 ka BP from the JJ Profile, located in the eastern Mu Us Sandy Lands. These RDEs appear to have occurred immediately following periods marked by persistently frequent and intense fires. We argue that such fire patterns, directly linked to an uncontrolled human use of vegetation as fuel, played a key role in accelerating RDEs by ensuring that the land surface was degraded beyond the threshold required for rapid desertification. This would suggest that the future use of a massive and sustained ecological program of vegetation rehabilitation should reduce the risk of destructive fire.

  1. Halo Coupling and Cleaning by a Space Charge Resonance in High Intensity Beams

    CERN Document Server

    Hofmann, Ingo

    2013-01-01

    We show that the difference resonance driven by the space charge pseudo-octupole of high-intensity beams not only couples the beam core emittances; it can also lead to emittance exchange in the beam halo, which is of relevance for beam loss in high intensity accelerators. With reference to linear accelerators the "main resonance" kz/kxy =1 (corresponding to the Montague resonance 2Qx-2Qy=0 in circular accelerators) may lead to such a coupling and transfer of halo between planes. Coupling of transverse halo into the longitudinal plane - or vice versa - can occur even if the core (rms) emittances are exactly or nearly equal. This halo argument justifies additional caution in linac design including consideration of avoiding an equipartitioned design. At the same time, however, this mechanism may also qualify as active dynamical halo cleaning scheme by coupling a halo from the longitudinal plane into the transverse plane, where local scraping is accessible. We present semi-analytical emittance coupling rates and ...

  2. Simulation study of the high intensity S-Band photoinjector

    Energy Technology Data Exchange (ETDEWEB)

    Zhu, Xiongwei; Nakajima, Kazuhisa [High Energy Accelerator Research Organization, Tsukuba, Ibaraki (Japan)

    2001-10-01

    In this paper, we report the results of simulation study of the high intensity S-Band photoinjector. The aim of the simulation study is to transport high bunch charge with low emittance evolution. The simulation result shows that 7nC bunch with rms emittance 22.3 {pi} mm mrad can be outputted at the exit of photoinjector. (author)

  3. Reuse Recycler: High Intensity Proton Stacking at Fermilab

    Energy Technology Data Exchange (ETDEWEB)

    Adamson, P. [Fermilab

    2016-07-17

    After a successful career as an antiproton storage and cooling ring, Recycler has been converted to a high intensity proton stacker for the Main Injector. We discuss the commissioning and operation of the Recycler in this new role, and the progress towards the 700 kW design goal.

  4. Parallel Beam Dynamics Code Development for High Intensity Cyclotron

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    <正>1 Parallel PIC algorithm Self field solver is the key part of a high intensity beam dynamic PIC code which usually adopts the P-M (Particle-Mesh) method to solve the space charge. The P-M method is composed of four major

  5. Nonlinear Behavior in High-Intensity Discharge Lamps

    CERN Document Server

    Baumann, Bernd; Wolff, Marcus; Manders, Freddy; Suijker, Jos

    2015-01-01

    The light flicker problem of high intensity discharge lamps is studied numerically and experimentally. It is shown that in some respects the systems behaves very similar to the forced Duffing oscillator with a softening spring. In particular, the jump phenomenon and hysteresis are observed in the simulations and in the experiments.

  6. High-Intensity Interval Training for Improving Postprandial Hyperglycemia

    Science.gov (United States)

    Little, Jonathan P.; Francois, Monique E.

    2014-01-01

    High-intensity interval training (HIIT) has garnered attention in recent years as a time-efficient exercise option for improving cardiovascular and metabolic health. New research demonstrates that HIIT may be particularly effective for improving postprandial hyperglycemia in individuals with, or at risk for, type 2 diabetes (T2D). These findings…

  7. Acute plasma volume change with high-intensity sprint exercise.

    Science.gov (United States)

    Bloomer, Richard J; Farney, Tyler M

    2013-10-01

    When exercise is of long duration or of moderate to high intensity, a decrease in plasma volume can be observed. This has been noted for both aerobic and resistance exercise, but few data are available with regard to high-intensity sprint exercise. We measured plasma volume before and after 3 different bouts of acute exercise, of varying intensity, and/or duration. On different days, men (n = 12; 21-35 years) performed aerobic cycle exercise (60 minutes at 70% heart rate reserve) and 2 different bouts of cycle sprints (five 60-second sprints at 100% maximum wattage obtained during graded exercise testing (GXT) and ten 15-second sprints at 200% maximum wattage obtained during GXT). Blood was collected before and 0, 30, and 60 minutes postexercise and analyzed for hematocrit and hemoglobin and plasma volume was calculated. Plasma volume decreased significantly for all exercise bouts (p sprint bouts (∼19%) compared with aerobic exercise bouts (∼11%). By 30 minutes postexercise, plasma volume approached pre-exercise values. We conclude that acute bouts of exercise, in particular high-intensity sprint exercise, significantly decrease plasma volume during the immediate postexercise period. It is unknown what, if any negative implications these transient changes may have on exercise performance. Strength and conditioning professionals may aim to rehydrate athletes appropriately after high-intensity exercise bouts.

  8. High intensity single bunch operation with heavy periodic transient beam loading in wide band rf cavities

    Science.gov (United States)

    Tamura, Fumihiko; Hotchi, Hideaki; Schnase, Alexander; Yoshii, Masahito; Yamamoto, Masanobu; Ohmori, Chihiro; Nomura, Masahiro; Toda, Makoto; Shimada, Taihei; Hasegawa, Katsushi; Hara, Keigo

    2015-09-01

    The rapid cycling synchrotron (RCS) in the Japan Proton Accelerator Research Complex (J-PARC) was originally designed to accelerate two high intensity bunches, while some of neutron experiments in the materials and life science experimental facility and a muon experiment using main ring beams require a single bunch operation mode, in which one of the two rf buckets is filled and the other is empty. The beam intensity in the single bunch operation has been limited by longitudinal beam losses due to the rf bucket distortions by the wake voltage of the odd harmonics (h =1 ,3 ,5 ) in the wide band magnetic alloy cavities. We installed an additional rf feedforward system to compensate the wake voltages of the odd harmonics (h =1 ,3 ,5 ). The additional system has a similar structure as the existing feedforward system for the even harmonics (h =2 ,4 ,6 ). We describe the function of the feedforward system for the odd harmonics, the commissioning methodology, and the commissioning results. The longitudinal beam losses during the single bunch acceleration disappeared with feedforward for the odd harmonics. We also confirmed that the beam quality in the single bunch acceleration are similar to that of the normal operation with two bunches. Thus, high intensity single bunch acceleration at the intensity of 2.3 ×1013 protons per bunch has been achieved in the J-PARC RCS. This article is a follow-up of our previous article, Phys. Rev. ST Accel. Beams 14, 051004 (2011). The feedforward system extension for single bunch operation was successful.

  9. High-intensity focused ultrasound therapy: an overview for radiologists.

    Science.gov (United States)

    Kim, Young-sun; Rhim, Hyunchul; Choi, Min Joo; Lim, Hyo Keun; Choi, Dongil

    2008-01-01

    High-intensity focused ultrasound therapy is a novel, emerging, therapeutic modality that uses ultrasound waves, propagated through tissue media, as carriers of energy. This completely non-invasive technology has great potential for tumor ablation as well as hemostasis, thrombolysis and targeted drug/gene delivery. However, the application of this technology still has many drawbacks. It is expected that current obstacles to implementation will be resolved in the near future. In this review, we provide an overview of high-intensity focused ultrasound therapy from the basic physics to recent clinical studies with an interventional radiologist's perspective for the purpose of improving the general understanding of this cutting-edge technology as well as speculating on future developments.

  10. Review of High-intensity Interval Training in Cardiac Rehabilitation.

    Science.gov (United States)

    Ito, Shigenori; Mizoguchi, Tatsuya; Saeki, Tomoaki

    2016-01-01

    For the secondary prevention of cardiovascular disease, comprehensive cardiac rehabilitation is required. This involves optimal medical therapy, education on nutrition and exercise therapy, and smoking cessation. Of these, efficient exercise therapy is a key factor. A highly effective training protocol is therefore warranted, which requires a high rate of compliance. Although moderate-intensity continuous training has been the main training regimen recommended in cardiac rehabilitation guidelines, high-intensity interval training has been reported to be more effective in the clinical and experimental setting from the standpoint of peak oxygen uptake and central and peripheral adaptations. In this review, we illustrate the scientific evidence for high-intensity interval training. We then verify this evidence and discuss its significance and the remaining issues.

  11. Plasma-based polarization modulator for high-intensity lasers

    Science.gov (United States)

    Chen, Zi-Yu; Pukhov, Alexander

    2016-12-01

    Manipulation of laser pulses at high intensities is an important yet challenging issue. New types of plasma-based optical devices are promising alternatives to achieve this goal. Here we propose to modulate the polarization state of intense lasers based on oblique reflection from solid-plasma surfaces. A new analytical description is presented considering the plasma as an uniaxial medium that causes birefringence effect. Particle-in-cell simulation results numerically demonstrate that such a scheme can provide a tunable polarization control of the laser pulses even in the relativistic regime. The results are thus relevant for the design of compact, easy to use, and versatile polarization modulators for high-intensity laser pulses.

  12. High-Intensity Focused Ultrasound Therapy: an Overview for Radiologists

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Young Sun; Rhim, Hyun Chul; Lim, Hyo Keun; Choi, Dong Il [Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Choi, Min Joo [College of Medicine, Cheju National University, Jeju (Korea, Republic of)

    2008-08-15

    High-intensity focused ultrasound therapy is a novel, emerging, therapeutic modality that uses ultrasound waves, propagated through tissue media, as carriers of energy. This completely non-invasive technology has great potential for tumor ablation as well as hemostasis, thrombolysis and targeted drug/gene delivery. However, the application of this technology still has many drawbacks. It is expected that current obstacles to implementation will be resolved in the near future. In this review, we provide an overview of high-intensity focused ultrasound therapy from the basic physics to recent clinical studies with an interventional radiologist's perspective for the purpose of improving the general understanding of this cutting-edge technology as well as speculating on future developments

  13. Spallation neutron source and other high intensity froton sources

    Energy Technology Data Exchange (ETDEWEB)

    Weiren Chou

    2003-02-06

    This lecture is an introduction to the design of a spallation neutron source and other high intensity proton sources. It discusses two different approaches: linac-based and synchrotron-based. The requirements and design concepts of each approach are presented. The advantages and disadvantages are compared. A brief review of existing machines and those under construction and proposed is also given. An R&D program is included in an appendix.

  14. Energy gain and spectral tailoring of ion beams using ultra-high intensity laser beams

    Science.gov (United States)

    Prasad, Rajendra; Swantusch, Marco; Cerchez, Mirela; Spickermann, Sven; Auorand, Bastian; Wowra, Thomas; Boeker, Juergen; Willi, Oswald

    2015-11-01

    The field of laser driven ion acceleration over the past decade has produced a huge amount of research. Nowadays, several multi-beam facilities with high rep rate system, e.g. ELI, are being developed across the world for different kinds of experiments. The study of interaction dynamics of multiple beams possessing ultra-high intensity and ultra-short pulse duration is of vital importance. Here, we present the first experimental results on ion acceleration using two ultra-high intensity beams. Thanks to the unique capability of Arcturus laser at HHU Düsseldorf, two almost identical, independent beams in laser parameters such as intensity (>1020 W/cm2), pulse duration (30 fs) and contrast (>1010), could be accessed. Both beams are focused onto a 5 μm thin Ti target. While ensuring spatial overlap of the two beams, at relative temporal delay of ~ 50 ps (optimum delay), the proton and carbon ion energies were enhanced by factor of 1.5. Moreover, strong modulation in C4+ions near the high energy cut-off is observed later than the optimum delay for the proton enhancement. This offers controlled tailoring of the spectral content of heavy ions.

  15. Characteristics of Spatial Distribution for Peak Ground Acceleration in 3 Aug 2014 Ms6.5 Ludian Earthquake, Yuanan, China

    Science.gov (United States)

    kun, Chen; YanXiang, Yu

    2016-04-01

    Considering the geological context, focal mechanism solutions, aftershock distribution and attenuation characteristics of the ground motion in western China, shakemaps of PGA (Peak Ground Acceleration) for The Ludian Ms6.5 earthquake on 3 Aug 2014 was acquired, in which the Mothed of rapid generation ShakeMaps considering site effects was used, and the peak ground acceleration of 62 stations for this earthquake was used as interpolation. Then, distribution of PGA was amended by using PGA observations to correct system bias of theoretical estimates in the area without PGA observations. The results show that the attenuation of ground motion with distance for this earthquake was faster than that of Wang Su-Yun in 2000; the result of bias-corrected was more consistent with attenuation law of this earthquake. After adjusting, for the area with PGA greater than 40 cm / s2 was nearly 8000 km2, which was is reduced by about 40%.

  16. The effect of progressive high-intensity inspiratory muscle training and fixed high-intensity inspiratory muscle training on the asymmetry of diaphragm thickness in stroke patients

    OpenAIRE

    Jung, Ju-hyeon; Kim, Nan-soo

    2015-01-01

    [Purpose] This study investigated the effects of progressive load and fixed load high-intensity inspiratory muscle training on the asymmetry of diaphragm thickness in stroke patients. [Subjects] Twenty-one stroke patients were assigned to one of three groups: progressive load high-intensity inspiratory muscle training (n = 8), fixed load high-intensity inspiratory muscle training (n = 6), and controls (n = 7). [Methods] The progressive load and fixed load high-intensity inspiratory muscle tra...

  17. Focusing and transport of high-intensity multi-MeV proton bunches from a compact laser-driven source

    Science.gov (United States)

    Busold, S.; Schumacher, D.; Deppert, O.; Brabetz, C.; Frydrych, S.; Kroll, F.; Joost, M.; Al-Omari, H.; Blažević, A.; Zielbauer, B.; Hofmann, I.; Bagnoud, V.; Cowan, T. E.; Roth, M.

    2013-10-01

    Laser ion acceleration provides for compact, high-intensity ion sources in the multi-MeV range. Using a pulsed high-field solenoid, for the first time high-intensity laser-accelerated proton bunches could be selected from the continuous exponential spectrum and delivered to large distances, containing more than 109 particles in a narrow energy interval around a central energy of 9.4 MeV and showing ≤30mrad envelope divergence. The bunches of only a few nanoseconds bunch duration were characterized 2.2 m behind the laser-plasma source with respect to arrival time, energy width, and intensity as well as spatial and temporal bunch profile.

  18. Filling History and Post-Breakup Acceleration of Sedimentation in Baiyun Sag,Deepwater Northern South China Sea

    Institute of Scientific and Technical Information of China (English)

    Zhou Di; Sun Zhen; Liao Jie; Zhao Zhongxian; He Min; Wu Xiangjie; Pang Xiong

    2009-01-01

    The Baiyun (白云) sag in the southern Pearl River Mouth basin is the largest and deepest sag in deepwater northern South China Sea.Researches and exploration in this sag have revealed many distinct features of the sag.This article reports its filling history through backstripping of depth data of interpreted sequence boundaries.Maps of sediment rates of 10 sequences from 49 Ma to the present were constructed,showing the spatio-temporal variation of the sediment rate.Three stages of sediment infilling,49-17.5 Ma,17.5-10.5 Ma,and 10.5-0 Mn,were divided by abrupt changes of sedimentary patterns.If the breakup of the South China Sea took place at ~30 Mn,significant pint-breakup acceleration of sedimentation was observed at 17.5-15.5 Ma and 13.8-12.5 Mn,indicating acceleration of subsidence at these times.We propose that the onset of strong post-breakup snbsidence at ~17.5 Ma was an important tectonic event that changed the pattern of sedimentation from discrete and medium-rate depmition centers in both main and south snbsags to restricted but high-rate deposition in the main snbsag.The cause and implications of this newly recognized event need tobe investigated.

  19. The development of a high intensity dance performance fitness test.

    Science.gov (United States)

    Redding, Emma; Weller, Peter; Ehrenberg, Shantel; Irvine, Sarah; Quin, Edel; Rafferty, Sonia; Wyon, Matthew; Cox, Carol

    2009-01-01

    While there is currently a validated dance-specific exercise method of measuring aerobic fitness, no such test has been developed to measure high intensity capabilities in dance. The purpose of this study was to initiate an intermittent high intensity dance-specific fitness test. The test was designed to be able to observe changes in heart rate (HR), thereby allowing for a measurement of physical fitness at high intensities. Sixteen professional dancers (4 males and 12 females) volunteered to take part in this study. The fitness test protocol consists of movements that are representative of contemporary dance, and contains exercise and rest periods that mimic the intermittent nature of dance. The participants performed four trials. The physiological variables measured were HR (b.min(-1)) for each one minute bout of the four minute test for all trials, oxygen uptake (VO(2)) throughout the test, and end blood lactate (BLa mmol.L) for each trial. In addition, five of the participants undertook a maximal oxygen uptake treadmill test, and the scores obtained were compared with those from the dance test. Results show HR consistency across each one minute bout of the test and across each of the four trials of testing for all participants, indicating that the test is reliable. There was good reliability between bouts of each trial (typical error as % of CV = 1.5), intraclass "r" = 0.8, and good reliability between the four trials (typical error as % of CV = 2.1), intraclass "r" = 0.82. There were no significant differences between the maximal VO(2) and BLa scores established in the treadmill and dance tests, demonstrating validity. Thus, the results of this study indicate that the high intensity dance-specific test is a reliable and valid means of assessing and monitoring the cardiovascular fitness of dancers. The test allows dancers to be assessed within an environment that they are accustomed to (the studio), using a mode of exercise that is relevant (dance), and it is

  20. Intelligent Controller of Digital High Intensity Discharge Lamp

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    High-intensity discharge (HID) lamps include these types of electrical lamps: mercury vapor, metal halide (also HQI), high-pressure sodium, low-pressure sodium and less commonly, xenon short-arc lamps. The light-producing element of these lamp types is a well-stabilized arc discharge contained within a refractory envelope (arc tube) with wall loading in excess of 3 W/cm (19.4 W/in.). Compared to fluorescent and incandescent lamps, HID lamps produce a much larger quantity of light in a relatively small package. With tests made by the National Quality Supervision and

  1. Use of High Intensity Focused Ultrasound for Treating Malignant Tumors

    Institute of Scientific and Technical Information of China (English)

    WenzhiChen; ZhibiaoWang; FengWu; JinBai; HuiZhu; JianzhongZou; KequanLi; FanglinXie; ZhilongWang

    2004-01-01

    OBJECTIVE To investigate the efficacy and side effects of high intensity focused ultrasound(HIFU) in the treatment of malignant solid tumors. METHODS Thirty patients who refused surgery and/or were refractory to chemotherapy were treated by HIFU alone, with the efficacy and side effects monitored as follows: observation of vital organ signs; functional assay of important organs; imaging examinations including: digital subtraction angiography (DSA), CT, MRI, single photon emission computed tomography (SPECT), large core needle biopsy, complications and metastasis. RESULTS After HIFU therapy, the vital signs remained stable and the functions of the heart, lung, kidney and liver were also normal. DSA images showed that small or larger arteries were not damaged. After a follow-up of 10-38 months(mean 23.1 months), 26 patients(87%) were alive. The volume of the tumor underwent complete regression in 10 patients. Shrinkage of the tumor volume ≥50% was observed in 13 patients. Eight of 13 patients were examined by large core needle biopsy, all showing necrosis and/or fibrosis though 3 patients(10%) had local recurrence. Two of these were retreated again by HIFU and the locally recurrent tumors were controlled. New metastases developed in 5 patients after H IFU. Two patients suffered from peripheral nerve injuriy and they have recovered during the follow-up. One patient developed skin injury. CONCLUSION High intensity focused ultrasound is effective and safe in the treatment of malignant solid tumors.

  2. Development of High Intensity Beam Emittance Measurement Unit

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Three sets of High Intensity Beam Emittance Measurement Units (HIBEMUs) are being developed at Peking University. They are HIBEMU-2 (slit-wire type, one direction), HIBEMU-3 (Allison scanner type, one direction) and HIBEMU-4 (slit-wire type, two directions). For HIBEMU-2 and HIBEMU-3, more recent work has been done on software redesign in order to measure beam emittance and to draw phase diagram more efficiently and precisely. Software for control and data processing of them were developed in Labveiw environment, trying to improve calculation rationality and to offer user-friendly interface. Mechanical modification was also done for HIBEMU-3, mainly concentrating on the protection of Faraday cups from being overheated by the high intensity beam and also from interference of secondary electrons. This paper will also cover the mechanical structure as well as the software development of HIBEMU-4, which is a two-direction emittance scanner newly designed and manufactured for the high energy beam transport (HEBT) of Peking University Neutron Imaging FaciliTY (PKUNIFTY). At the end of this paper, comparison and analysis of the three HIBEMUs are given to draw forth better design of the future emittance measurement facility.

  3. High Intensity Particle Physics at PW-class laser facilities

    Science.gov (United States)

    Bulanov, Stepan; Schroeder, Carl; Esarey, Eric; Esirkepov, Timur; Kando, Masaki; Rosanov, Nikolay; Korn, Georg; Bulanov, Sergey V.; Leemans, Wim P.

    2015-11-01

    The processes typical for high intensity particle physics, i.e., the interactions of charged particles with strong electromagnetic fields, have attracted considerable interest recently. Some of these processes, previously believed to be of theoretical interest only, are now becoming experimentally accessible. High intensity electromagnetic (EM) fields significantly modify the interactions of particles and EM fields, giving rise to the phenomena that are not encountered either in classical or perturbative quantum theory of these interactions. One of such phenomena is the radiation reaction, which radically influences the electron motion in an electromagnetic standing wave formed by two super-intense counter-propagating laser pulses. Depending on the laser intensity and wavelength, either classical or quantum mode of radiation reaction prevail, or both are strong. When radiation reaction dominates, electron motion evolves to limit cycles and strange attractors. This creates a new framework for high energy physics experiments on an interaction of energetic charged particle beams and colliding super-intense laser pulses. Work supported by U.S. DOE under Contract No. DE-AC02-05CH11231.

  4. Accelerating the Adoption of Second-Tier Reach Standards forApplicable Appliance Products in China

    Energy Technology Data Exchange (ETDEWEB)

    Lin, Jiang; Fridley, David

    2007-03-01

    The minimum energy efficiency standards program for household appliances in China was initiated in 1989. Since 1996, CLASP and its implementing partner, LBNL, have assisted China in developing 11 minimum energy performance standards (MEPS) for 9 products and endorsement labels for 11 products including: refrigerators; air conditioners; clothes washers; televisions; printers; computers; monitors; fax machines; copiers; DVD/VCD players; external power supplies; and set-top boxes (under development). Before 2003, China's traditional approach to standards development involved small increases in efficiency requirements for implementation within 6 months of a standard's approval. Since 2003, China has adopted a new approach in setting MEPS. This new approach involves the development of two tiers of standards--one for initial implementation and a second tier at a more aggressive level of energy efficiency for implementation three to five years later. The second-tier standard is also referred to as a 'reach standard'. Reach standards have now been developed in China for: color TVs; refrigerators; air conditioners; and external power supplies. This report is presented in five sections. After the introduction in Section 1, Section 2 analyzes the distribution of the efficiency of refrigerators and air-conditioners in China based on data collected by the China Energy Label Center for the mandatory energy information label program. The results provide an assessment of the adoption of reach standards for these two products. Section 3 summarizes on-going collaborations with Shanghai related to early local adoption of reach standards, and presents both the impact and an analysis of barriers to the local adoption of reach standard for air-conditioners. Section 4 offers suggestions for local governments on how to move forward in adopting reach standards in their localities and concludes with a summary of the results and a plan for developing local capacity in

  5. Report of the Snowmass M6 Working Group on high intensity proton sources

    Energy Technology Data Exchange (ETDEWEB)

    Weiren Chou and J. Wei

    2002-08-20

    The U.S. high-energy physics program needs an intense proton source, a 1-4 MW Proton Driver (PD), by the end of this decade. This machine will serve as a stand-alone facility that will provide neutrino superbeams and other high intensity secondary beams such as kaons, muons, neutrons, and anti-protons (cf. E1 and E5 group reports) and also serve as the first stage of a neutrino factory (cf. M1 group report). It can also be a high brightness source for a VLHC. Based on present accelerator technology and project construction experience, it is both feasible and cost-effective to construct a 1-4 MW Proton Driver. Two recent PD design studies have been made, one at FNAL and the other at the BNL. Both designed PD's for 1 MW proton beams at a cost of about U.S. $200M (excluding contingency and overhead) and both designs were upgradeable to 4 MW. An international collaboration between FNAL, BNL and KEK on high intensity proton facilities is addressing a number of key design issues. The superconducting (sc) RF cavities, cryogenics, and RF controls developed for the SNS can be directly adopted to save R&D efforts, cost, and schedule. PD studies are also actively being pursued at Europe and Japan.

  6. High-Intensity Sweeteners in Alternative Tobacco Products

    Science.gov (United States)

    Miao, Shida; Beach, Evan S.; Sommer, Toby J.; Zimmerman, Julie B.

    2016-01-01

    Introduction: Sweeteners in tobacco products may influence use initiation and reinforcement, with special appeal to adolescents. Recent analytical studies of smokeless tobacco products (snuff, snus, dissolvables) detected flavorants identical to those added to confectionary products such as hard candy and chewing gum. However, these studies did not determine the levels of sweeteners. The objective of the present study was to quantify added sweeteners in smokeless tobacco products, a dissolvable product, electronic cigarette liquids and to compare with sweetener levels in confectionary products. Methods: Sweetener content of US-sourced smokeless tobacco, electronic cigarette liquid, and confectionary product samples was analyzed by liquid chromatography-electrospray ionization–mass spectrometry (LC-ESI-MS). Results: All smokeless products contained synthetic high intensity sweeteners, with snus and dissolvables exceeding levels in confectionary products (as much as 25-fold). All snus samples contained sucralose and most also aspartame, but no saccharin. In contrast, all moist snuff samples contained saccharin. The dissolvable sample contained sucralose and sorbitol. Ethyl maltol was the most common sweet-associated component in electronic cigarette liquids. Discussion: Sweetener content was dependent on product category, with saccharin in moist snuff, an older category, sucralose added at high levels to more recently introduced products (snus, dissolvable) and ethyl maltol in electronic cigarette liquid. The very high sweetener concentrations may be necessary for the consumer to tolerate the otherwise aversive flavors of tobacco ingredients. Regulation of sweetener levels in smokeless tobacco products may be an effective measure to modify product attractiveness, initiation and use patterns. Implications: Dissolvables, snus and electronic cigarettes have been promoted as risk-mitigation products due to their relatively low content of nitrosamines and other tobacco

  7. Ionization Chambers for Monitoring in High-Intensity Neutrino Beams

    CERN Document Server

    McDonald, J; Velissaris, C; Erwin, A R; Ping, H; Viren, B M; Diwan, M V

    2002-01-01

    Radiation-hard ionization chambers were tested using an intense electron beam from the accelerator test facility (ATF) at the Brookhaven National Laboratory (BNL). The detectors were designed to be used as the basic element for monitoring muons in the Main Injector Neutrino beamline (NuMI) at the Fermi National Accelerator Laboratory (FNAL). Measurements of linearity of response, voltage dependence, and the onset of ionization saturation as a function of gap voltage were performed.

  8. High Intensity Beam Issues in the CERN Proton Synchrotron

    CERN Document Server

    Aumon, Sandra; Rivkin, Leonid

    This PhD work is about limitations of high intensity proton beams observed in the CERN Proton Synchrotron (PS) and, in particular, about issues at injection and transition energies. With its 53 years, the CERN PS would have to operate beyond the limit of its performance to match the future requirements. Beam instabilities driven by transverse impedance and aperture restrictions are important issues for the operation and for the High-Luminosity LHC upgrade which foresees an intensity increase delivered by the injectors. The main subject of the thesis concerns the study of a fast transverse instability occurring at transition energy. The proton beams crossing this energy range are particularly sensitive to wake forces because of the slow synchrotron motion. This instability can cause a strong vertical emittance blow-up and severe losses in less than a synchrotron period. Experimental observations show that the particles at the peak density of the beam longitudinal distribution oscillate in the vertical plane du...

  9. Increased collection efficiency of LIFI high intensity electrodeless light source

    Science.gov (United States)

    Hafidi, Abdeslam; DeVincentis, Marc; Duelli, Markus; Gilliard, Richard

    2008-02-01

    Recently, RF driven electrodeless high intensity light sources have been implemented successfully in the projection display systems for HDTV and videowall applications. This paper presents advances made in the RF waveguide and electric field concentrator structures with the purpose of reducing effective arc size and increasing light collection. In addition, new optical designs are described that further improve system efficiency. The results of this work demonstrate that projection system light throughput is increased relative to previous implementations and performance is optimized for home theater and other front projector applications that maintain multi-year lifetime without re-lamping, complete spectral range, fast start times and high levels of dynamic contrast due to dimming flexibility in the light source system.

  10. Vortex dynamics and shear layer instability in high intensity cyclotrons

    CERN Document Server

    Cerfon, Antoine J

    2016-01-01

    We show that the space charge dynamics of high intensity beams in the plane perpendicular to the magnetic field in cyclotrons is described by the two-dimensional Euler equations for an incompressible fluid. This analogy with fluid dynamics gives a unified and intuitive framework to explain the beam spiraling and beam break up behavior observed in experiments and in simulations. In particular, we demonstrate that beam break up is the result of a classical instability occurring in fluids subject to a sheared flow. We give scaling laws for the instability and predict the nonlinear evolution of beams subject to it. Our work suggests that cyclotrons may be uniquely suited for the experimental study of shear layers and vortex distributions that are not achievable in Penning-Malmberg traps.

  11. Fermilab main injector: High intensity operation and beam loss control

    Science.gov (United States)

    Brown, Bruce C.; Adamson, Philip; Capista, David; Chou, Weiren; Kourbanis, Ioanis; Morris, Denton K.; Seiya, Kiyomi; Wu, Guan Hong; Yang, Ming-Jen

    2013-07-01

    From 2005 through 2012, the Fermilab Main Injector provided intense beams of 120 GeV protons to produce neutrino beams and antiprotons. Hardware improvements in conjunction with improved diagnostics allowed the system to reach sustained operation at 400 kW beam power. Transmission was very high except for beam lost at or near the 8 GeV injection energy where 95% beam transmission results in about 1.5 kW of beam loss. By minimizing and localizing loss, residual radiation levels fell while beam power was doubled. Lost beam was directed to either the collimation system or to the beam abort. Critical apertures were increased while improved instrumentation allowed optimal use of available apertures. We will summarize the improvements required to achieve high intensity, the impact of various loss control tools and the status and trends in residual radiation in the Main Injector.

  12. Design of a high-intensity RFQ for a possible LHC laser ion source

    CERN Document Server

    Hanke, K

    2002-01-01

    We have designed a 100 MHz RFQ to accelerate Pb25+ ions from 9.6 keV/u to 250 keV/u for the LHC ion program. We assume an input beam from a laser ion source with a total beam current of 90 mA, out of which 9 mA is Pb25+. The main challenge of the design is to match the tight longitudinal acceptance of the downstream Interdigital H structure while dealing with a high intensity beam composed of a variety of charge states. In this paper, we present a baseline setup optimized for nominal conditions, and show the sensitivity of the RFQ performance to varying input beam characteristics and rf parameters. Further studies will cover the compatibility of this design with an upgraded ECR source under investigation at CERN.

  13. Dynamics of self-generated, large amplitude magnetic fields following high-intensity laser matter interaction

    CERN Document Server

    Sarri, G; Cecchetti, C A; Kar, S; Liseykina, T V; Yang, X H; Dieckmann, M E; Fuchs, J; Galimberti, M; Gizzi, L A; Jung, R; Kourakis, I; Osterholz, J; Pegoraro, F; Robinson, A P L; Romagnani, L; Willi, O; Borghesi, M

    2012-01-01

    The dynamics of magnetic fields with amplitude of several tens of Megagauss, generated at both sides of a solid target irradiated with a high intensity (? 1019W/cm2) picosecond laser pulse, has been spatially and temporally resolved using a proton imaging technique. The amplitude of the magnetic fields is sufficiently large to have a constraining effect on the radial expansion of the plasma sheath at the target surfaces. These results, supported by numerical simulations and simple analytical modeling, may have implications for ion acceleration driven by the plasma sheath at the rear side of the target as well as for the laboratory study of self-collimated high-energy plasma jets.

  14. Radiation Dose Measurement for High-Intensity Laser Interactions with Solid Targets at SLAC

    Energy Technology Data Exchange (ETDEWEB)

    Liang, Taiee [SLAC National Accelerator Lab., Menlo Park, CA (United States)

    2015-09-25

    A systematic study of photon and neutron radiation doses generated in high-intensity laser-solid interactions is underway at SLAC National Accelerator Laboratory. We found that these laser-solid experiments are being performed using a 25 TW (up to 1 J in 40 fs) femtosecond pulsed Ti:sapphire laser at the Linac Coherent Light Source’s (LCLS) Matter in Extreme Conditions (MEC) facility. Additionally, radiation measurements were performed with passive and active detectors deployed at various locations inside and outside the target chamber. Results from radiation dose measurements for laser-solid experiments at SLAC MEC in 2014 with peak intensity between 1018 to 7.1x1019 W/cm2 are presented.

  15. Laser Stripping via a Broad Stark State for a High-Intensity Proton Ring

    CERN Document Server

    Yamane, I; Takayama, K; Yamane, Isao; Suzuki, Toshikazu; Takayama, Ken

    2002-01-01

    A new type of charge-exchange injection scheme for high-intensity proton rings that use a laser beam and an undulator magnet is proposed. The elementary stripping process is resonant photoionization via a broad Stark state formed by the Stark effect at an energy level near the peak of the potential barrier. The method used to estimate the parameters of the necessary laser beam and magnetic field is described. As an application to an actual accelerator, a laser stripping system using a high-finesse Fabry-Perot resonator and an undulator is proposed. An estimation of the photon loss due to the pumping-up of H$^0$ atoms, tunability of the system and the emittance growth due to stripping in the undulator magnet is also given.

  16. Lighting up the Christmas tree: high-intensity laser interactions with a nano-structured target

    CERN Document Server

    Gonoskov, A; Ilderton, A; Mackenroth, F; Marklund, M

    2014-01-01

    We perform a numerical study of the interaction of a high-intensity laser pulse with a nano-structured target. In particular, we study a target where the nano-structuring increases the absorption rate as compared to the flat target case. The transport of electrons within the target, and in particular in the nano-structure, is analysed. It is shown that it is indeed possible, using a terawatt class laser, to light up a nano-scale Christmas tree. Due to the form of the tree we achieve very strong edge fields, in particular at the top where the star is located. Such edge fields, as here located at ion rich spots, makes strong acceleration gradients possible. It also results in a nice, warm glow suitable for the holiday season.

  17. RADIATION DOSE MEASUREMENTS FOR HIGH-INTENSITY LASER INTERACTIONS WITH SOLID TARGETS AT SLAC.

    Science.gov (United States)

    Liang, T; Bauer, J; Cimeno, M; Ferrari, A; Galtier, E; Granados, E; Lee, H J; Liu, J; Nagler, B; Prinz, A; Rokni, S; Tran, H; Woods, M

    2016-12-01

    A systematic study of photon and neutron radiation doses generated in high-intensity laser-solid interactions is underway at SLAC National Accelerator Laboratory. These laser-solid experiments are being performed using a 25 TW (up to 1 J in 40 fs) femtosecond pulsed Ti:sapphire laser at the Linac Coherent Light Source's (LCLS) Matter in Extreme Conditions (MEC) facility. Radiation measurements were performed with passive and active detectors deployed at various locations inside and outside the target chamber. Results from radiation dose measurements for laser-solid experiments at SLAC MEC in 2014 with peak intensity between 10(18) and 7.1 × 10(19) W cm(-2) are presented.

  18. Construction of material and life science experimental facility under high intensity proton accelerator project

    CERN Document Server

    Ikeda, Y

    2002-01-01

    The outline of construction of 1MW pulse spallation neutron source in the MLF experimental facility is explained in this paper. The object, project activities, project team and construction of group are stated. 1MW pulse nuclear spallation neutron source, neutron source design and technical problems, Hg target, the basic parameters, neutron source station, moderator, reflector, shield, shutter, low temperature system, facility, spectrometer, and neutron experimental device are explained. The nuclear calculation code and nuclear data used as technical support and computer environment are illustrated. (S.Y.)

  19. An improved permanent magnet quadrupole design with larger good field region for high intensity proton linacs

    Science.gov (United States)

    Mathew, Jose V.; Rao, S. V. L. S.; Krishnagopal, S.; Singh, P.

    2013-11-01

    The Low Energy High Intensity Proton Accelerator (LEHIPA), being developed at the Bhabha Atomic Research Centre (BARC) will produce a 20 MeV, 30 mA, continuous wave (CW) proton beam. At these low velocities, space-charge forces dominate, and could lead to larger beam sizes and beam halos. Hence in the design of the focusing lattice of the LEHIPA drift tube linac (DTL) using permanent magnet quadrupoles (PMQs), a larger good field region is preferred. Here we study, using the two dimensional (2D) and three dimensional (3D) simulation codes PANDIRA and RADIA, four different types of cylindrical PMQ designs: 16-segment trapezoidal Halbach configuration, bullet-nosed geometry and 8- and 16-segment rectangular geometries. The trapezoidal Halbach geometry is used in a variety of accelerators since it provides very high field gradients in small bores, while the bullet-nosed geometry, which is a combination of the trapezoidal and rectangular designs, is used in some DTLs. This study shows that a larger good field region is possible in the 16-segment rectangular design as compared to the Halbach and bullet-nosed designs, making it more attractive for high-intensity proton linacs. An improvement in good-field region by ˜16% over the Halbach design is obtained in the optimized 16-segment rectangular design, although the field gradient is lower by ˜20%. Tolerance studies show that the rectangular segment PMQ design is substantially less sensitive to the easy axis orientation errors and hence will be a better choice for DTLs.

  20. High Intensity High Charge State ECR Ion Sources

    CERN Document Server

    Leitner, Daniela

    2005-01-01

    The next-generation heavy ion beam accelerators such as the proposed Rare Isotope Accelerator (RIA), the Radioactive Ion Beam Factory at RIKEN, the GSI upgrade project, the LHC-upgrade, and IMP in Lanzhou require a great variety of high charge state ion beams with a magnitude higher beam intensity than currently achievable. High performance Electron Cyclotron Resonance (ECR) ion sources can provide the flexibility since they can routinely produce beams from hydrogen to uranium. Over the last three decades, ECR ion sources have continued improving the available ion beam intensities by increasing the magnetic fields and ECR heating frequencies to enhance the confinement and the plasma density. With advances in superconducting magnet technology, a new generation of high field superconducting sources is now emerging, designed to meet the requirements of these next generation accelerator projects. The talk will briefly review the field of high performance ECR ion sources and the latest developments for high intens...

  1. Proton Drivers for neutrino beams and other high intensity applications

    CERN Document Server

    Garoby, R; Koseki, T; Thomason, J

    2013-01-01

    CERN, Fermilab, J-PARC and RAL tentatively plan to have proton accelerators delivering multi-MW of beam power in view of enhancing their physics reach especially in the domain of neutrinos. These plans are described, together with their benefits for other applications.

  2. Laser-energy transfer and enhancement of plasma waves and electron beams by interfering high-intensity laser pulses.

    Science.gov (United States)

    Zhang, P; Saleh, N; Chen, S; Sheng, Z M; Umstadter, D

    2003-11-28

    The effects of interference due to crossed laser beams were studied experimentally in the high-intensity regime. Two ultrashort (400 fs), high-intensity (4 x 10(17) and 1.6 x 10(18) W/cm(2)) and 1 microm wavelength laser pulses were crossed in a plasma of density 4 x 10(19) cm(3). Energy was observed to be transferred from the higher-power to the lower-power pulse, increasing the amplitude of the plasma wave propagating in the direction of the latter. This results in increased electron self-trapping and plasma-wave acceleration gradient, which led to an increased number of hot electrons (by 300%) and hot-electron temperature (by 70%) and a decreased electron-beam divergence angle (by 45%), as compared with single-pulse illumination. Simulations reveal that increased stochastic heating of electrons may have also contributed to the electron-beam enhancement.

  3. Nanobiotechnology promotes noninvasive high-intensity focused ultrasound cancer surgery.

    Science.gov (United States)

    Chen, Yu; Chen, Hangrong; Shi, Jianlin

    2015-01-07

    The successful cancer eradication in a noninvasive manner is the ultimate objective in the fight against cancer. As a "bloodless scalpel," high-intensity focused ultrasound (HIFU) is regarded as one of the most promising and representative noninvasive therapeutic modalities for cancer surgery. However, large-scale clinical applications of HIFU are still in their infancy because of critical efficiency and safety issues which remain to be solved. Fortunately, recently developed nanobiotechnology provides an alternative efficient approach to improve such important issues in HIFU, especially for cancer therapy. This Research News presents the very recent exciting progresses on the elaborate design and fabrication of organic, inorganic, and organic/inorganic hybrid nanoparticles for enhancing the HIFU ablation efficiency against tumor tissues. It is highly expected that this Research News can arouse more extensive research enthusiasm on the development of functional nanomaterials for highly efficient HIFU-based synergistic therapy, which will give a promising noninvasive therapeutic modality for the successful cancer therapy with minimal damage to surrounding normal tissues, due to the noninvasive and site-specific therapeutic features of HIFU.

  4. Robotic Assisted Laparoscopic Prostatectomy after High Intensity Focused Ultrasound Failure

    Directory of Open Access Journals (Sweden)

    Leon Telis

    2017-01-01

    Full Text Available Background. Prostate cancer is the most common cancer diagnosed in men. As new focal therapies become more popular in treatment of prostate cancer, failure cases requiring salvage therapy with either surgical or other techniques are being reported. Objective. To report the options in treatment of prostate cancer after recurrence or failure of the primary treatment modality. Methods. We report a salvage robotic assisted laparoscopic radical prostatectomy (RALP for prostate cancer recurrence following high intensity focused ultrasound treatment (HIFU in the United States. Results. A 67-year-old man who underwent HIFU treatment for prostate adenocarcinoma 2 years prior was presented with a rising prostate specific antigen of 6.1 ng/mL to our clinic. A biopsy proven recurrent disease in the area of previous treatment documented the failure of treatment. The patient elected to undergo a salvage RALP. The operation time was 159 minutes. The patient was discharged from the hospital on postoperative day 1 with no complications. The catheter was removed on post-op day 10. The patient reserved sexual function and urinary continence. The PSA levels on 6 months’ follow-up are undetectable. Conclusions. Salvage RALP is an effective and safe treatment choice for recurrent prostate adenocarcinoma following failed HIFU treatment if operated by an experienced surgeon.

  5. Formation of a high intensity low energy positron string

    Science.gov (United States)

    Donets, E. D.; Donets, E. E.; Syresin, E. M.; Itahashi, T.; Dubinov, A. E.

    2004-05-01

    The possibility of a high intensity low energy positron beam production is discussed. The proposed Positron String Trap (PST) is based on the principles and technology of the Electron String Ion Source (ESIS) developed in JINR during the last decade. A linear version of ESIS has been used successfully for the production of intense highly charged ion beams of various elements. Now the Tubular Electron String Ion Source (TESIS) concept is under study and this opens really new promising possibilities in physics and technology. In this report, we discuss the application of the tubular-type trap for the storage of positrons cooled to the cryogenic temperatures of 0.05 meV. It is intended that the positron flux at the energy of 1-5 eV, produced by the external source, is injected into the Tubular Positron Trap which has a similar construction as the TESIS. Then the low energy positrons are captured in the PST Penning trap and are cooled down because of their synchrotron radiation in the strong (5-10 T) applied magnetic field. It is expected that the proposed PST should permit storing and cooling to cryogenic temperature of up to 5×109 positrons. The accumulated cooled positrons can be used further for various physics applications, for example, antihydrogen production.

  6. Blood coagulation using High Intensity Focused Ultrasound (HIFU)

    Science.gov (United States)

    Nguyen, Phuc V.; Oh, Junghwan; Kang, Hyun Wook

    2014-03-01

    High Intensity Focused Ultrasound (HIFU) technology provides a feasible method of achieving thermal coagulation during surgical procedures. One of the potential clinical benefits of HIFU can induce immediate hemostasis without suturing. The objective of this study was to investigate the efficiency of a HIFU system for blood coagulation on severe vascular injury. ngHIFU treatment was implemented immediately after bleeding in artery. The ultrasound probe was made of piezoelectric material, generating a central frequency of 2.0 MHz as well as an ellipsoidal focal spot of 2 mm in lateral dimension and 10 mm in axial dimension. Acoustic coagulation was employed on a perfused chicken artery model in vitro. A surgical incision (1 to 2 mm long) was made with a scapel on the arterial wall, and heparinized autologous blood was made to leak out from the incision with a syringe pump. A total of 5 femoral artery incisions was treated with the HIFU beam. The intensity of 4500 W/cm2 at the focus was applied for all treatments. Complete hemostasis was achieved in all treatments, along with the treatment times of 25 to 50 seconds. The estimated intraoperative blood loss was from 2 to 5 mL. The proposed HIFU system may provide an effective method for immediate blood coagulation for arteries and veins in clinical applications.

  7. High-intensity positron microprobe at Jefferson Lab

    CERN Document Server

    Golge, Serkan; Wojtsekhowski, Bogdan

    2014-01-01

    We present a conceptual design for a novel continuous wave electron-linac based high-intensity slow-positron production source with a projected intensity on the order of 10$^{10}$ e$^+$/s. Reaching this intensity in our design relies on the transport of positrons (T$_+$ below 600 keV) from the electron-positron pair production converter target to a low-radiation and low-temperature area for moderation in a high-efficiency cryogenic rare gas moderator, solid Ne. The performance of the integrated beamline has been verified through computational studies. The computational results include Monte Carlo calculations of the optimized electron/positron beam energies, converter target thickness, synchronized raster system, transport of the beam from the converter target to the moderator, extraction of the beam from the channel, and moderation efficiency calculations. For the extraction of positrons from the magnetic channel a magnetic field terminator plug prototype has been built and experimental data on the effective...

  8. Treatment of glaucoma with high intensity focused ultrasound.

    Science.gov (United States)

    Aptel, Florent; Lafon, Cyril

    2015-05-01

    Glaucoma is a common disease mainly due to an increase in pressure inside the eye, leading to a progressive destruction of the optic nerve, potentially to blindness. Intraocular pressure (IOP) is the result of a balance between production of liquid that fills the eye--aqueous humour--and its resorption. All treatments for glaucoma aim to reduce IOP and can therefore have two mechanisms of action: reducing aqueous humour production by the partial destruction or medical inhibition of the ciliary body--the anatomical structure responsible for production of aqueous humour--or facilitating the evacuation of aqueous humour from the eye. Several physical methods can be used to destroy the ciliary body, e.g. laser, cryotherapy, microwave. All these methods have two major drawbacks: they are non-selective for the organ to be treated and they have an unpredictable dose–effect relationship. High intensity focused ultrasound (HIFU) can be used to coagulate the ciliary body and avoid these drawbacks. A commercially available device was marketed in the 1980s, but later abandoned, essentially for technical reasons. A smaller circular device using miniaturised transducers was recently developed and proposed for clinical practice. Experimental studies have shown selective coagulation necrosis of the treated ciliary body. The first three clinical trials in humans have shown that this device was well tolerated and allowed a significant, predictable and sustained reduction of IOP. The aim of this contribution is to present a summary of the work concerning the use of HIFU to treat glaucoma.

  9. Echinococcus granulosus: protoscolicidal effect of high intensity focused ultrasound.

    Science.gov (United States)

    Zou, Xiaoyi; Wang, Junan; Zhao, Hailong; Zhang, Jing; Wu, Weihua; Ye, Bin

    2009-04-01

    High intensity focused ultrasound (HIFU) is a new non-invasive technique which can cause cell death and tissue necrosis by focusing high-energy ultrasonic waves on a single location. The aim of our work is to investigate the damaging effect of HIFU on Echinococcus granulosus protoscolices, as well as its inhibitory effect on growth of hydatid cysts derived from protoscolices. The damaging effect of HIFU on protoscolices was investigated by following parasite mortality after irradiation, while the inhibitory effect was investigated by infection experiments in vivo. The results demonstrated that HIFU was able to damage protoscolices and the protoscolicidal effect was dose-dependent and showed late-onset. The growth of protoscolices that survived the exposure to HIFU was obviously suppressed in vitro, and the mean weight of hydatid cysts resulting from such protoscolices in the experimental group was less than that in controls. Evidences including the protoscolicidal effect, fragmentized protoscolices and low post exposure temperatures, suggest that cavitation may contribute to the protoscolicidal effect of HIFU. In addition, the structure of the germinal membrane in cysts developing from the irradiated protoscolices was not as normal or intact as that from non-irradiated ones, and morphological changes related to degeneration were observed, suggesting that HIFU could prevent protoscolices from developing normal germinal membrane and consequently stop the proliferation of secondary hydatid cysts. HIFU demonstrated damaging effect on protoscolices, inhibited the growth of protoscolices in vitro and in vivo, and could be a possible therapeutic option for cystic echinococcosis.

  10. A review of adolescent high-intensity interval training.

    Science.gov (United States)

    Logan, Greig R M; Harris, Nigel; Duncan, Scott; Schofield, Grant

    2014-08-01

    Despite the promising evidence supporting positive effects of high-intensity interval training (HIIT) on the metabolic profile in adults, there is limited research targeting adolescents. Given the rising burden of chronic disease, it is essential to implement strategies to improve the cardiometabolic health in adolescence, as this is a key stage in the development of healthy lifestyle behaviours. This narrative review summarises evidence of the relative efficacy of HIIT regarding the metabolic health of adolescents. Methodological inconsistencies confound our ability to draw conclusions; however, there is meaningful evidence supporting HIIT as a potentially efficacious exercise modality for use in the adolescent cohort. Future research must examine the effects of various HIIT protocols to determine the optimum strategy to deliver cardiometabolic health benefits. Researchers should explicitly show between-group differences for HIIT intervention and steady-state exercise or control groups, as the magnitude of difference between HIIT and other exercise modalities is of key interest to public health. There is scope for research to examine the palatability of HIIT as an exercise modality for adolescents through investigating perceived enjoyment during and after HIIT, and consequent long-term exercise adherence.

  11. Effect of a high-intensity weight-bearing exercise program on radiologic damage progression of the large joints in subgroups of patients with rheumatoid arthritis.

    NARCIS (Netherlands)

    Munneke, M.; Jong, Z. de; Zwinderman, A.H.; Ronday, H.K.; Schaardenburg, D. van; Dijkmans, B.A.C.; Kroon, H.M.; Vliet Vlieland, T.P.M.; Hazes, J.M.W.

    2005-01-01

    OBJECTIVE: To investigate whether a high-intensity exercise program accelerates the rate of radiologic damage of the large joints in predefined subgroups of patients with rheumatoid arthritis. METHODS: The data of 277 participants in a 2-year randomized controlled trial, comparing the effects of hig

  12. Creatine kinase response to high-intensity aerobic exercise in adult-onset muscular dystrophy

    DEFF Research Database (Denmark)

    Andersen, Søren P; Sveen, Marie-Louise; Hansen, Regitze S;

    2013-01-01

    We investigated the effect of high-intensity exercise on plasma creatine kinase (CK) in patients with muscular dystrophies.......We investigated the effect of high-intensity exercise on plasma creatine kinase (CK) in patients with muscular dystrophies....

  13. COLLIMATORS AND MATERIALS FOR HIGH INTENSITY HEAVY ION SYNCHROTRONS

    CERN Document Server

    Stadlmann, J; Kollmus, H; Spiller, P; Strasik, I; Tahir, N A; Tomut, M; Trautmann, C

    2012-01-01

    The operation of high power high brightness accelerators requires huge efforts for beam cleaning and machine protection. Within the WP 8 (ColMat) of the EU research framework EuCARD[1] we investigate new materials and methods for beam collimation and machine protection. We present an overview of these activities at the GSI Helmholtzzentrum f¨ur Schwerionenforschung, Darmstadt. Simulations of accidental beam losses in LHC and SIS100 have been performed. Scenarios for halo collimation of heavy ions and protons in SIS100 routine operation have been investigated. A prototype of a cryogenic collimator for charge exchange losses during intermediate charge state heavy ion operation in SIS100 has been build and tested with beam. Several candidates of advanced composite materials for collimation system upgrades of present and future high power accelerators have been irradiated and their properties are being characterized. Most deliverables and milestones of the R&D programme were already reached before the end of...

  14. FFAG-BASED HIGH-INTENSITY PROTON DRIVERS.

    Energy Technology Data Exchange (ETDEWEB)

    RUGGIERO, A.G.

    2004-10-13

    This paper is the summary of a feasibility study of a Fixed-Field Alternating-Gradient (FFAG) Accelerator for Protons in the one-to-few GeV energy range, and average beam power of several MWatt. The example they have adopted here is a beam energy of 1 GeV and an average power of 10 MWatt, but of course the same design approach can be used with other beam parameters. The design principles, merits and limitations of the FFAG accelerators have been described previously. In particular, more advanced techniques to minimize magnet dimension and field strength have been recently proposed. The design makes use of a novel concept by which it is possible to cancel chromatic effects, thus making betatron tunes and functions independent of the particle momentum, with an Adjusted Field Profile. The example given here assumes a pulsed mode of operation at the repetition rate of 1.0 kHz.

  15. Beam dynamic design of a high intensity injector for proton linac

    Energy Technology Data Exchange (ETDEWEB)

    Dou, Wei-Ping, E-mail: douweiping@impcas.ac.cn [Institute of Modern Physics, The Chinese Academy of Sciences, Lanzhou 73000 (China); Wang, Zhi-Jun [Institute of Modern Physics, The Chinese Academy of Sciences, Lanzhou 73000 (China); Jia, Fang-Jian [State Key Lab of Nuclear Physics and Technology, Peking University, Beijing 100847 (China); He, Yuan, E-mail: hey@impcas.ac.cn [Institute of Modern Physics, The Chinese Academy of Sciences, Lanzhou 73000 (China); Wang, Zhi; Lu, Yuan-Rong [State Key Lab of Nuclear Physics and Technology, Peking University, Beijing 100847 (China)

    2016-08-11

    A compact room-temperature injector is designed to accelerate 100 mA proton beam from 45 keV to 4.06 MeV for the proposed high intensity proton linac at State Key Lab of Nuclear Physics and Technology in Peking university. The main feature is that the Radio Frequency Quadruple (RFQ) and the Drift Tube linac (DTL) sections are merged in one piece at the total length of 276 cm. The beam is matched in transverse directions with an compact internal doublet instead of an external matching section in between. The design has reached a high average accelerating gradient up to 1.55 MV/m with transmission efficiency of 95.9% at the consideration of high duty factor operation. The operation frequency is chose to be 200 MHz due to the already available RF power source. The injector combines a 150 cm long 4-vanes RFQ internal section from 45 keV to 618 keV with a 126 cm long H-type DTL section to 4.06 MeV. In general the design satisfy the challenges of the project requirements. And the details are presented in this paper.

  16. Tune measurements with high intensity ion beams at GSI SIS-18

    Energy Technology Data Exchange (ETDEWEB)

    Singh, Rahul [GSI, Darmstadt (Germany); TEMF, TU Darmstadt (Germany); Forck, Peter; Kowina, Piotr; Kaufmann, Wolfgang [GSI, Darmstadt (Germany); Weiland, Thomas [TEMF, TU Darmstadt (Germany)

    2012-07-01

    A precise tune measurement during a full accelerating cycle is required to achieve stable high current operation. A new system has been commissioned at GSI for position, orbit and tune measurements. It consists of three distinct parts; an exciter which provides power to excite coherent betatron oscillations in the bunched beam; Fast ADCs to digitize the BPM signals at 125 MSa/s; the post processing electronics uses digitized BPM signals to acquire one position value per bunch. Subsequently the baseband tune is determined by Fourier transformation of the position data. Experiments were conducted to understand the effects of high beam intensity on tune at injection plateau (11.4 MeV/u) and during acceleration ramp (11.4-600 MeV/u). These experiments were performed with U{sup 73+} and Ar{sup 18+} ion beam at highest achievable intensities of 2.10{sup 9} and 2.5.10{sup 10} respectively. Tune shift with increased intensity was observed. The working principle of the tune measurement system and observed high intensity effects on tune will be reported in this contribution.

  17. Aspects of operation of the Fermilab Booster RF System at very high intensity

    Energy Technology Data Exchange (ETDEWEB)

    Griffin, J.E.

    1996-04-01

    The purpose of this note is to examine the likelihood and problems associated with operation of the Fermilab Booster rf systems as it presently exists, or with only minor modifications, at beam intensity approaching 5x10{sup 13} protons per pulse. Beam loading of the rf system at such an intensity will be one order of magnitude larger than at the present operation level. It is assumed that the injection energy will be raised to 1 GeV with no major increase in the injected energy spread (longitudinal emittance). The beam will be bunched by adiabatic capture as is presently done although it may be necessary to remove one or two bunches prior to acceleration to allow clean extraction at 8 GeV. At very high intensity the charge in each bunch will interact with the vacuum chamber impedance (and with itself) in such a way as to reduce in some cases the bucket area generated by the rf voltage. Because this decrement must be made up by changes in the rf ring voltage if the required bucket area is to be maintained, these effects must be taken into consideration in any analysis of the capability of the rf system to accelerate very large intensity.

  18. Beam dynamic design of a high intensity injector for proton linac

    Science.gov (United States)

    Dou, Wei-Ping; Wang, Zhi-Jun; Jia, Fang-Jian; He, Yuan; Wang, Zhi; Lu, Yuan-Rong

    2016-08-01

    A compact room-temperature injector is designed to accelerate 100 mA proton beam from 45 keV to 4.06 MeV for the proposed high intensity proton linac at State Key Lab of Nuclear Physics and Technology in Peking university. The main feature is that the Radio Frequency Quadruple (RFQ) and the Drift Tube linac (DTL) sections are merged in one piece at the total length of 276 cm. The beam is matched in transverse directions with an compact internal doublet instead of an external matching section in between. The design has reached a high average accelerating gradient up to 1.55 MV/m with transmission efficiency of 95.9% at the consideration of high duty factor operation. The operation frequency is chose to be 200 MHz due to the already available RF power source. The injector combines a 150 cm long 4-vanes RFQ internal section from 45 keV to 618 keV with a 126 cm long H-type DTL section to 4.06 MeV. In general the design satisfy the challenges of the project requirements. And the details are presented in this paper.

  19. Acceleration of modern acidification in the South China Sea driven by anthropogenic CO₂.

    Science.gov (United States)

    Liu, Yi; Peng, Zicheng; Zhou, Renjun; Song, Shaohua; Liu, Weiguo; You, Chen-Feng; Lin, Yen-Po; Yu, Kefu; Wu, Chung-Che; Wei, Gangjian; Xie, Luhua; Burr, George S; Shen, Chuan-Chou

    2014-06-03

    Modern acidification by the uptake of anthropogenic CO2 can profoundly affect the physiology of marine organisms and the structure of ocean ecosystems. Centennial-scale global and regional influences of anthropogenic CO2 remain largely unknown due to limited instrumental pH records. Here we present coral boron isotope-inferred pH records for two periods from the South China Sea: AD 1048-1079 and AD 1838-2001. There are no significant pH differences between the first period at the Medieval Warm Period and AD 1830-1870. However, we find anomalous and unprecedented acidification during the 20th century, pacing the observed increase in atmospheric CO2. Moreover, pH value also varies in phase with inter-decadal changes in Asian Winter Monsoon intensity. As the level of atmospheric CO2 keeps rising, the coupling global warming via weakening the winter monsoon intensity could exacerbate acidification of the South China Sea and threaten this expansive shallow water marine ecosystem.

  20. Recent High-Intensity Experiments at the Trident Laser

    Science.gov (United States)

    Cobble, James; Palaniyappan, Sasikumar; Gautier, Cort; Kim, Yongho; Huang, Chengkun

    2014-10-01

    With near-diffraction-limited irradiance of 2 × 1020 W/cm2 on target and prelase contrast better than 10-8, we have accessed the regime of relativistic transparency (RT) at the Trident Laser. The goal was to assess electron debris emitted from the target rear surface with phase-contrast imaging (PCI) and current density measurements (hence, the total electron current). Companion diagnostics show whether the experiments are in the target-normal-sheath-acceleration mode or in the RT regime. The superb laser contrast allows us to shoot targets as thin as 50 nm. PCI at 527 nm is temporally resolved to 600 fs. It has shown the evolution of electron behavior over tens of ps, including thermal electrons accompanying the ion jet, accelerated to many tens of MeV earlier in time. Faraday-cup measurements indicate the transfer of many microC of charge during the laser drive. As a ride-along experiment using a gas Cherenkov detector (GCD), we have detected gamma rays of energy >5 MeV. This radiation has a prompt component and a lesser source, driven by accelerated ions, that is time resolved by the GCD. The ion time of flight is compared to Thomson parabola data. Electron energy spectra are also collected. This work is supported by US DOE/NNSA, performed at LANL, operated by LANS LLC under Contract DE-AC52-06NA25396.

  1. Inelastic scattering in condensed matter with high intensity Moessbauer radiation

    Energy Technology Data Exchange (ETDEWEB)

    Yelon, W.B.; Schupp, G.

    1990-10-01

    We give a progress report for the work which has been carried out in the last three years with DOE support. A facility for high-intensity Moessbauer scattering is now fully operational at the University of Missouri Research Reactor (MURR) as well as facility at Purdue, using special isotopes produced at MURR. High precision, fundamental Moessbauer effect studies have been carried out using scattering to filter the unwanted radiation. These have led to a new Fourier transform method for describing Moessbauer effect (ME) lineshape and a direct method of fitting ME data to the convolution integral. These methods allow complete correction for source resonance self absorption (SRSA) and the accurate representation of interference effects that add an asymmetric component to the ME lines. We have begun applying these techniques to attenuated ME sources whose central peak has been attenuated by stationary resonant absorbers, to more precisely determine interference parameters and line-shape behavior in the resonance asymptotic region. This analysis is important to both the fundamental ME studies and to scattering studies for which a deconvolution is essential for extracting the correct recoilless fractions and interference parameters. A number of scattering studies have been successfully carried out including a study of the thermal diffuse scattering in Si, which led to an analysis of the resolution function for gamma-ray scattering. Also studied was the anharmonic motion in Na and the satellite reflection Debye-Waller factor in TaS{sub 2}, which indicate phason rather than phonon behavior. We have begun quasielastic diffusion studies in viscous liquids and current results are summarized. These advances, coupled to our improvements in MIcrofoil Conversion Electron spectroscopy lay the foundation for the proposed research outlined in this request for a three-year renewal of DOE support.

  2. Gamma scattering in condensed matter with high intensity Moessbauer radiation

    Energy Technology Data Exchange (ETDEWEB)

    1990-01-01

    We give a progress report for the work which has been carried out in the last three years with DOE support. A facility for high-intensity Moessbauer scattering is now fully operational at the University of Missouri Research Reactor (MURR) as well as a facility at Purdue, using special isotopes produced at MURR. High precision, fundamental Moessbauer effect studies have been carried out using scattering to filter the unwanted radiation. These have led to a new Fourier transform method for describing Moessbauer effect (ME) lineshape and a direct method of fitting ME data to the convolution integral. These methods allow complete correction for source resonance self absorption (SRSA) and the accurate representation of interference effects that add an asymmetric component to the ME lines. We have begun applying these techniques to attenuated ME sources whose central peak has been attenuated by stationary resonant absorbers, to more precisely determine interference parameters and line-shape behavior in the resonance asymptotic region. This analysis is important to both the fundamental ME studies and to scattering studies for which a deconvolution is essential for extracting the correct recoilless fractions and interference parameters. A number of scattering studies have been successfully carried out including a study of the thermal diffuse scattering in Si, which led to an analysis of the resolution function for gamma-ray scattering. Also studied was the anharmonic motion in Na and the satellite reflection Debye-Waller factor in TaS{sub 2}, which indicate phason rather than phonon behavior. We have begun quasielastic diffusion studies in viscous liquids and current results are summarized. These advances, coupled to our improvements in MIcrofoil Conversion Electron spectroscopy lay the foundation for the proposed research outlined in this request for a three-year renewal of DOE support.

  3. HIGH-INTENSITY FOCUSED ULTRASOUND CASTRATION FOR BREAST CANCER PATIENTS

    Institute of Scientific and Technical Information of China (English)

    王书文; 和新盈; 石景森; 赵东利; 李明众; 王诚; 薛文华

    2003-01-01

    Objective: To evaluate the safety and efficacy of external high-intensity focused ultrasound(HIFU) castration for breast cancerous patients after mastectomy if they are at a high risk of recurrence. Methods: We recruited 52 consecutive patients with primary operable breast cancer who were treated with mastectomy with excision of regional lymph nodes. Patients were positive for ER and PR immuno- cytochemical staining, node-positive, un-menopause, over 40 years old and were divided into two groups randomly. For castration, 26 patients received one or two times of HIFU treatment within five days, and the other patients received radiotherapy with DT 18Gy/9 f/11days. During and after the treatment, local changes and systemic response of the patients were observed. Results: After 1 month treatment, levels of serum E1 and E2 were significantly decreased compared to before treatment in HIFU groups (P<0.01 and P<0.001). The same changes were occurred in radiotherapy(RT) groups (P<0.05 and P<0.01). The levels of serum E1 or E2 in RT groups were higher than in HIFU groups (P<0.05). The symptom distribution of 'climacteric syndrome' of HIFU groups were significantly different from RT groups (P<0.01). The follow-up time was 4 months. The incidence of amenorrhea was 100% in all patients. No serious complications were seen. The temperature, pulse, blood pressure, and respiratory rate of the patients were almost normal. Conclusion: We have shown that the use of HIFU in the castrating of patients with breast cancer is feasible, safe and effective. This technology may provide a rapid noninvasive alterative to conventional bilateral oophorectomy or RT castration.

  4. A novel image-guided high-intensity focused ultrasound system for tumor treatment

    Science.gov (United States)

    Wu, Zhiqiang; Wu, Puwei; Chen, Bojie; Guan, Jian; Huang, Zheng

    2004-07-01

    A novel ultrasonography-guided high intensity focused ultrasound (HIFU) system (FS-100; Force Electronics Co. Ltd, Chongqing, China) was developed for non-invasive thermal ablation of tumor. The proprietary therapy delivery system is an integration of the digital image progressing, automatic control and the high intensity focused ultrasound thermal ablation devices. The therapeutic ultrasound probe (φ = 240 mm) consists of eight circular HIFU transducers with a curved surface of a diameter of 60 mm. Dual focused beams generated from the probe were used in this system for thermal delivery. The probe has the maximal resonance frequency of 1 MHz, a maximal treatment depth of 160 mm and focal spot diameter of 3 mm. The maximal intensity at the focal spot is 10,000 W/cm2. The imaging and HIFU components are located on top of the device, therefore, the focused ultrasound beams can be delivered to the patient in a supine position. The motion, targeting and localization of the probe are controlled by a PMAC-PC motion controller and an 8-independent-axis mechanical device. The linear motion error of the probe localization is <= 0.1 mm. The ultrasonographic image information is used for treatment planning and therapeutic interventions, such as target definition and registration, visualization of the three-dimensional anatomy of desired target(s), automatic positioning the thermal beams on targets, controlling thermal delivery, and rapid evaluation of target response post-treatment. The preclinical experimental results will be presented. The safety, feasibility and effectiveness of this novel HIFU system will be tested.

  5. Parasitic slow extraction of extremely weak beam from a high-intensity proton rapid cycling synchrotron

    Science.gov (United States)

    Zou, Ye; Tang, Jingyu; Yang, Zheng; Jing, Hantao

    2014-02-01

    This paper proposes a novel method to extract extremely weak beam from a high-intensity proton rapid cycling synchrotron (RCS) in the parasitic mode, while maintaining the normal fast extraction. The usual slow extraction method from a synchrotron by employing third-order resonance cannot be applied in a high-intensity RCS due to a very short flat-top at the extraction energy and the strict control on beam loss. The proposed parasitic slow extraction method moves the beam to scrape a scattering foil prior to the fast beam extraction by employing either a local orbit bump or momentum deviation or their combination, so that the halo part of the beam will be scattered. A part of the scattered particles will be extracted from the RCS and guided to the experimental area. The slow extraction process can last about a few milliseconds before the beam is extracted by the fast extraction system. The method has been applied to the RCS of China Spallation Neutron Source. With 1.6 GeV in the extraction energy, 62.5 μA in the average current and 25 Hz in the repetition rate for the RCS, the proton intensity by the slow extraction method can be up to 2×104 protons per cycle or 5×105 protons per second. The extracted beam has also a good time structure of approximately uniform in a spill which is required for many applications such as detector tests. Detailed studies including the scattering effect in the foil, the local orbit bump by the bump magnets and dispersive orbit bump by modifying the RF pattern, the multi-particle simulations by ORBIT and TURTLE codes, and some technical features for the extraction magnets are presented.

  6. The Accelerated Urbanization Process: A Threat to Soil Resources in Eastern China

    Directory of Open Access Journals (Sweden)

    Jiadan Li

    2015-06-01

    Full Text Available The eastern coastal region of China has been experiencing rapid urbanization which has imposed great challenges on soil resources, characterized by soil sealing and fragmented soil landscapes. Taking Zhejiang Province—a fairly economically-developed and highly-urbanized region in eastern China—as a case study, a practical framework that integrates remote sensing, GIS, soil quality assessment and landscape analysis was employed to track and analyze the rapid urbanization process and spatiotemporal dynamics of soil sealing and landscape change from 1990 to 2010. Meanwhile, this paper qualitatively explored the regional inequality and characteristics in soil sealing intensity among cities of different geo-zones in Zhejiang Province. Results showed that total area of 6420 km2 had been sealed during the past two decades for the entire study area, which represents 6.2% of the provincial area. Among these sealed soils, 68.6% are fertile soils located in flat plains, such as Paddy soils. Soil landscapes became more fragmented and dispersed in distribution, more irregular and complex in shape, and less dominant and diverse in soil type, as evidenced by the constant change of various spatial landscape metrics. What is more, different geo-zones exhibited significant differences in dynamics of soil sealing intensity, soil composition and soil landscape patterns. The permanent loss of valuable soil resource and increasing fragmented soil landscape patterns concomitant with rapid urbanization processes may inevitably bring about potential threats to regional soil resources and food security.

  7. An improved permanent magnet quadrupole design with larger good field region for high intensity proton linacs

    Energy Technology Data Exchange (ETDEWEB)

    Mathew, Jose V., E-mail: josev.mathew@gmail.com; Rao, S.V.L.S.; Krishnagopal, S.; Singh, P.

    2013-11-01

    The Low Energy High Intensity Proton Accelerator (LEHIPA), being developed at the Bhabha Atomic Research Centre (BARC) will produce a 20 MeV, 30 mA, continuous wave (CW) proton beam. At these low velocities, space-charge forces dominate, and could lead to larger beam sizes and beam halos. Hence in the design of the focusing lattice of the LEHIPA drift tube linac (DTL) using permanent magnet quadrupoles (PMQs), a larger good field region is preferred. Here we study, using the two dimensional (2D) and three dimensional (3D) simulation codes PANDIRA and RADIA, four different types of cylindrical PMQ designs: 16-segment trapezoidal Halbach configuration, bullet-nosed geometry and 8- and 16-segment rectangular geometries. The trapezoidal Halbach geometry is used in a variety of accelerators since it provides very high field gradients in small bores, while the bullet-nosed geometry, which is a combination of the trapezoidal and rectangular designs, is used in some DTLs. This study shows that a larger good field region is possible in the 16-segment rectangular design as compared to the Halbach and bullet-nosed designs, making it more attractive for high-intensity proton linacs. An improvement in good-field region by ∼16% over the Halbach design is obtained in the optimized 16-segment rectangular design, although the field gradient is lower by ∼20%. Tolerance studies show that the rectangular segment PMQ design is substantially less sensitive to the easy axis orientation errors and hence will be a better choice for DTLs. -- Highlights: • An improved permanent magnet quadrupole (PMQ) design with larger good field region is proposed. • We investigate four PMQ designs, including the widely used Halbach and bullet nosed designs. • Analytical calculations are backed by 2D as well as 3D numerical solvers, PANDIRA and RADIA. • The optimized 16 segment rectangular PMQ design is identified to exhibit the largest good field region. • The effect of easy axis orientation

  8. FNAL Proton Source High Intensity Operations and Beam Loss Control

    CERN Document Server

    Garcia, F G

    2014-01-01

    The 40-year-old Fermilab Proton Source machines, constituted by the Pre-Injector, Linac and the synchrotron Booster, have been the workhorse of the Fermi National Accelerator Laboratory (Fermilab). During this time, the High Energy Physics Program has demanded an increase in proton throughput, especially during the past decade with the beginning of the neutrino program at Fermilab. In order to achieve a successful program, major upgrades and changes were made in Booster. Once again, the Proton Source has been charged to double their beam throughput, while maintain the present residual activation levels, to meet the laboratory Intensity Frontier program goals until new machines are built and operational to replace the Proton Source machines. This paper discusses the present performance of Booster and the plans involved in reaching even higher intensities.

  9. Interaction of High Intensity Electromagnetic Waves with Plasmas

    Energy Technology Data Exchange (ETDEWEB)

    G. Shvets

    2008-10-03

    The focus of our work during the duration of this grant was on the following areas: (a) the fundamental plasma physics of intense laser-plasma interactions, including the nonlinear excitation of plasma waves for accelerator applications, as well as the recently discovered by us phenomenon of the relativistic bi-stability of relativistic plasma waves driven by a laser beatwave; (b) interaction of high power microwave beams with magnetized plasma, including some of the recently discovered by us phenomena such as the Undulator Induced Transparency (UIT) as well as the new approaches to dynamic manipulation of microwave pulses; (c) investigations of the multi-color laser pulse interactions in the plasma, including the recently discovered by us phenomenon of Electromagnetic Cascading (EC) and the effect of the EC of three-dimensional dynamics of laser pulses (enhanced/suppressed selffocusing etc.); (d) interaction of high-current electron beams with the ambient plasma in the context of Fast Ignitor (FI) physics, with the emphasis on the nonlinear dynamics of the Weibel instability and beam filamentation.

  10. Pulsed x-ray imaging of high-density objects using a ten picosecond high-intensity laser driver

    Science.gov (United States)

    Rusby, D. R.; Brenner, C. M.; Armstrong, C.; Wilson, L. A.; Clarke, R.; Alejo, A.; Ahmed, H.; Butler, N. M. H.; Haddock, D.; Higginson, A.; McClymont, A.; Mirfayzi, S. R.; Murphy, C.; Notley, M.; Oliver, P.; Allott, R.; Hernandez-Gomez, C.; Kar, S.; McKenna, P.; Neely, D.

    2016-10-01

    Point-like sources of X-rays that are pulsed (sub nanosecond), high energy (up to several MeV) and bright are very promising for industrial and security applications where imaging through large and dense objects is required. Highly penetrating X-rays can be produced by electrons that have been accelerated by a high intensity laser pulse incident onto a thin solid target. We have used a pulse length of 10ps to accelerate electrons to create a bright x-ray source. The bremsstrahlung temperature was measured for a laser intensity from 8.5-12×1018 W/cm2. These x-rays have sequentially been used to image high density materials using image plate and a pixelated scintillator system.

  11. The effect of progressive high-intensity inspiratory muscle training and fixed high-intensity inspiratory muscle training on the asymmetry of diaphragm thickness in stroke patients.

    Science.gov (United States)

    Jung, Ju-Hyeon; Kim, Nan-Soo

    2015-10-01

    [Purpose] This study investigated the effects of progressive load and fixed load high-intensity inspiratory muscle training on the asymmetry of diaphragm thickness in stroke patients. [Subjects] Twenty-one stroke patients were assigned to one of three groups: progressive load high-intensity inspiratory muscle training (n = 8), fixed load high-intensity inspiratory muscle training (n = 6), and controls (n = 7). [Methods] The progressive load and fixed load high-intensity inspiratory muscle training participants undertook an exercise program for 20 minutes, three times weekly, for 6 weeks. After each session, diaphragm thickness was measured using ultrasonography. The diaphragm asymmetry ratio and diaphragm thickening ratio were standardized using a formula. [Results] After intervention, the diaphragm asymmetry ratio significantly differed among the three groups, and the diaphragm asymmetry ratio significantly increased in the control group. A significant increase was identified in the diaphragm thickening ratio within the progressive load and fixed load high-intensity inspiratory muscle training groups. [Conclusion] Progressive load and fixed load high-intensity inspiratory muscle training decreased the asymmetry of diaphragm thickness in stroke patients; this effect, in turn, increased the diaphragm thickening ratio in stroke patients. The two interventions examined here should be selectively applied to individuals in the clinical field.

  12. Max Tech and Beyond: High-Intensity Discharge Lamps

    Energy Technology Data Exchange (ETDEWEB)

    Scholand, Michael

    2012-04-01

    High-intensity discharge (HID) lamps are most often found in industrial and commercial applications, and are the light source of choice in street and area lighting, and sports stadium illumination. HID lamps are produced in three types - mercury vapor (MV), high pressure sodium (HPS) and metal halide (MH). Of these, MV and MH are considered white-light sources (although the MV exhibits poor color rendering) and HPS produces a yellow-orange color light. A fourth lamp, low-pressure sodium (LPS), is not a HID lamp by definition, but it is used in similar applications and thus is often grouped with HID lamps. With the notable exception of MV which is comparatively inefficient and in decline in the US from both a sales and installed stock point of view; HPS, LPS and MH all have efficacies over 100 lumens per watt. The figure below presents the efficacy trends over time for commercially available HID lamps and LPS, starting with MV and LPS in 1930's followed by the development of HPS and MH in the 1960's. In HID lamps, light is generated by creating an electric arc between two electrodes in an arc tube. The particles in the arc are partially ionized, making them electrically conductive, and a light-emitting 'plasma' is created. This arc occurs within the arc tube, which for most HID lamps is enclosed within an evacuated outer bulb that thermally isolates and protects the hot arc tube from the surroundings. Unlike a fluorescent lamp that produces visible light through down-converting UV light with phosphors, the arc itself is the light source in an HID lamp, emitting visible radiation that is characteristic of the elements present in the plasma. Thus, the mixture of elements included in the arc tube is one critical factor determining the quality of the light emitted from the lamp, including its correlated color temperature (CCT) and color rendering index (CRI). Similar to fluorescent lamps, HID lamps require a ballast to start and maintain stable

  13. Max Tech and Beyond: High-Intensity Discharge Lamps

    Energy Technology Data Exchange (ETDEWEB)

    Scholand, Michael

    2012-04-01

    High-intensity discharge (HID) lamps are most often found in industrial and commercial applications, and are the light source of choice in street and area lighting, and sports stadium illumination. HID lamps are produced in three types - mercury vapor (MV), high pressure sodium (HPS) and metal halide (MH). Of these, MV and MH are considered white-light sources (although the MV exhibits poor color rendering) and HPS produces a yellow-orange color light. A fourth lamp, low-pressure sodium (LPS), is not a HID lamp by definition, but it is used in similar applications and thus is often grouped with HID lamps. With the notable exception of MV which is comparatively inefficient and in decline in the US from both a sales and installed stock point of view; HPS, LPS and MH all have efficacies over 100 lumens per watt. The figure below presents the efficacy trends over time for commercially available HID lamps and LPS, starting with MV and LPS in 1930's followed by the development of HPS and MH in the 1960's. In HID lamps, light is generated by creating an electric arc between two electrodes in an arc tube. The particles in the arc are partially ionized, making them electrically conductive, and a light-emitting 'plasma' is created. This arc occurs within the arc tube, which for most HID lamps is enclosed within an evacuated outer bulb that thermally isolates and protects the hot arc tube from the surroundings. Unlike a fluorescent lamp that produces visible light through down-converting UV light with phosphors, the arc itself is the light source in an HID lamp, emitting visible radiation that is characteristic of the elements present in the plasma. Thus, the mixture of elements included in the arc tube is one critical factor determining the quality of the light emitted from the lamp, including its correlated color temperature (CCT) and color rendering index (CRI). Similar to fluorescent lamps, HID lamps require a ballast to start and maintain stable

  14. Project X: Accelerator Reference Design

    CERN Document Server

    Holmes, S D; Chase, B; Gollwitzer, K; Johnson, D; Kaducak, M; Klebaner, A; Kourbanis, I; Lebedev, V; Leveling, A; Li, D; Nagaitsev, S; Ostroumov, P; Pasquinelli, R; Patrick, J; Prost, L; Scarpine, V; Shemyakin, A; Solyak, N; Steimel, J; Yakovlev, V; Zwaska, R

    2013-01-01

    Part 1 of "Project X: Accelerator Reference Design, Physics Opportunities, Broader Impacts". Part 1 contains the volume Preface and a description of the conceptual design for a high-intensity proton accelerator facility being developed to support a world-leading program of Intensity Frontier physics over the next two decades at Fermilab. Subjects covered include performance goals, the accelerator physics design, and the technological basis for such a facility.

  15. Low level RF systems for synchrotrons part II: High Intensity. Compensation of the beam induced effects

    CERN Document Server

    Baudrenghien, P

    2005-01-01

    The high intensity regime is reached when the voltage induced by the beam in the RF cavities is of an amplitude comparable to the desired accelerating voltage. In steady state this beam loading can be compensated by providing extra RF power. Transient beam loading occurs at injection or in the presence of a beam intensity that is not uniform around the ring. The transients are periodic at the revolution frequency. Without correction transient beam loading can be very harmful: The stable phase and bucket area will not be equal for all bunches. Strong beam loading often goes in pair with longitudinal instabilities because the RF cavities are a large contributor to the total ring impedance. The low level systems that reduce the effect of the transient beam loading will also increase the threshold intensity of the longitudinal instability caused by the cavity impedance at the fundamental RF frequency. Four classic methods are presented here: Feedforward, RF feedback, long delay feedback and bunch by bunch feedbac...

  16. The study towards high intensity high charge state laser ion sources

    Science.gov (United States)

    Zhao, H. Y.; Jin, Q. Y.; Sha, S.; Zhang, J. J.; Li, Z. M.; Liu, W.; Sun, L. T.; Zhang, X. Z.; Zhao, H. W.

    2014-02-01

    As one of the candidate ion sources for a planned project, the High Intensity heavy-ion Accelerator Facility, a laser ion source has been being intensively studied at the Institute of Modern Physics in the past two years. The charge state distributions of ions produced by irradiating a pulsed 3 J/8 ns Nd:YAG laser on solid targets of a wide range of elements (C, Al, Ti, Ni, Ag, Ta, and Pb) were measured with an electrostatic ion analyzer spectrometer, which indicates that highly charged ions could be generated from low-to-medium mass elements with the present laser system, while the charge state distributions for high mass elements were relatively low. The shot-to-shot stability of ion pulses was monitored with a Faraday cup for carbon target. The fluctuations within ±2.5% for the peak current and total charge and ±6% for pulse duration were demonstrated with the present setup of the laser ion source, the suppression of which is still possible.

  17. Tunable High-Intensity Electron Bunch Train Production Based on Nonlinear Longitudinal Space Charge Oscillation

    Science.gov (United States)

    Zhang, Zhen; Yan, Lixin; Du, Yingchao; Zhou, Zheng; Su, Xiaolu; Zheng, Lianmin; Wang, Dong; Tian, Qili; Wang, Wei; Shi, Jiaru; Chen, Huaibi; Huang, Wenhui; Gai, Wei; Tang, Chuanxiang

    2016-05-01

    High-intensity trains of electron bunches with tunable picosecond spacing are produced and measured experimentally with the goal of generating terahertz (THz) radiation. By imposing an initial density modulation on a relativistic electron beam and controlling the charge density over the beam propagation, density spikes of several-hundred-ampere peak current in the temporal profile, which are several times higher than the initial amplitudes, have been observed for the first time. We also demonstrate that the periodic spacing of the bunch train can be varied continuously either by tuning launching phase of a radio-frequency gun or by tuning the compression of a downstream magnetic chicane. Narrow-band coherent THz radiation from the bunch train was also measured with μ J -level energies and tunable central frequency of the spectrum in the range of ˜0.5 to 1.6 THz. Our results pave the way towards generating mJ-level narrow-band coherent THz radiation and driving high-gradient wakefield-based acceleration.

  18. Impact of high-intensity ultrasound on the formation of lactulose and Maillard reaction glycoconjugates.

    Science.gov (United States)

    Corzo-Martínez, Marta; Montilla, Antonia; Megías-Pérez, Roberto; Olano, Agustín; Moreno, F Javier; Villamiel, Mar

    2014-08-15

    The impact of high-intensity ultrasound (US) on the formation of lactulose during lactose isomerization and on the obtention of lysine-glucose glycoconjugates during Maillard reaction (MR) has been studied, respectively, in basic and neutral media. As compared to equivalent conventional heat treatments, a higher formation of furosine, as indicator of initial steps of MR, was observed together with more advance of the reaction in US treated samples, this effect being more pronounced with the increase of US amplitude (50-70%) and temperature (25-40 °C). Regarding the influence of US on lactulose formation, in general, in a buffered system (pH 10.0), US at 70% of amplitude and 60 °C increased the rate of lactose isomerization, higher values of lactulose, epilactose and galactose being observed in comparison to conventional heating. The results of this work showed an acceleration of both reactions by US, indicating its usefulness to promote the formation of functional ingredients.

  19. High-intensity interval exercise and cerebrovascular health: curiosity, cause, and consequence.

    Science.gov (United States)

    Lucas, Samuel J E; Cotter, James D; Brassard, Patrice; Bailey, Damian M

    2015-06-01

    Exercise is a uniquely effective and pluripotent medicine against several noncommunicable diseases of westernised lifestyles, including protection against neurodegenerative disorders. High-intensity interval exercise training (HIT) is emerging as an effective alternative to current health-related exercise guidelines. Compared with traditional moderate-intensity continuous exercise training, HIT confers equivalent if not indeed superior metabolic, cardiac, and systemic vascular adaptation. Consequently, HIT is being promoted as a more time-efficient and practical approach to optimize health thereby reducing the burden of disease associated with physical inactivity. However, no studies to date have examined the impact of HIT on the cerebrovasculature and corresponding implications for cognitive function. This review critiques the implications of HIT for cerebrovascular function, with a focus on the mechanisms and translational impact for patient health and well-being. It also introduces similarly novel interventions currently under investigation as alternative means of accelerating exercise-induced cerebrovascular adaptation. We highlight a need for studies of the mechanisms and thereby also the optimal dose-response strategies to guide exercise prescription, and for studies to explore alternative approaches to optimize exercise outcomes in brain-related health and disease prevention. From a clinical perspective, interventions that selectively target the aging brain have the potential to prevent stroke and associated neurovascular diseases.

  20. Production of high intensity electron bunches for the SLAC Linear Collider

    Energy Technology Data Exchange (ETDEWEB)

    James, M.B.

    1987-08-01

    This thesis describes the design and performance of a high intensity electron injecfor for the SLAC Linear Collider. Motivation for the collider and the specifications for the injector are discussed. An analytic theory of the bunching and capture of electrons by rf fields is discussed in the limit of low space charge and small signal. The design and performance of SLAC's main injector are described to illustrate a successful application of this theory. The bunching and capture of electrons by rf fields are then discussed in the limit of high space charge and large signal, and a description of the design of the collider injector follows. In the limit of high space charge forces and large rf signals, the beam dynamics are considerably more complex and numerical simulations are required to predict particle motion. A computer code which models the longitudinal dynamics of electrons in the presence of space charge and rf fields is described. The results of the simulations, the resulting collider injector design and the various components which make up the collider injector are described. These include the gun, subharmonic bunchers, traveling-wave buncher and velocity-of-light accelerator section. Finally, the performance of the injector is described including the beam intensity, bunch length, transverse emittance and energy spectrum. While the final operating conditions differ somewaht from the design, the performance of the collider injector is in good agreement with the numerical simulations and meets all of the collider specifications. 28 refs.

  1. Tunable High-Intensity Electron Bunch Train Production Based on Nonlinear Longitudinal Space Charge Oscillation

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Zhen; Yan, Lixin; Du, Yingchao; Zhou, Zheng; Su, Xiaolu; Zheng, Lianmin; Wang, Dong; Tian, Qili; Wang, Wei; Shi, Jiaru; Chen, Huaibi; Huang, Wenhui; Gai, Wei; Tang, Chuanxiang

    2016-05-05

    High-intensity trains of electron bunches with tunable picosecond spacing are produced and measured experimentally with the goal of generating terahertz (THz) radiation. By imposing an initial density modulation on a relativistic electron beam and controlling the charge density over the beam propagation, density spikes of several-hundred-ampere peak current in the temporal profile, which are several times higher than the initial amplitudes, have been observed for the first time. We also demonstrate that the periodic spacing of the bunch train can be varied continuously either by tuning launching phase of a radiofrequency gun or by tuning the compression of a downstream magnetic chicane. Narrow-band coherent THz radiation from the bunch train was also measured with μJ-level energies and tunable central frequency of the spectrum in the range of ~0.5 to 1.6 THz. Our results pave the way towards generating mJ-level narrow-band coherent THz radiation and driving high-gradient wakefield-based acceleration.

  2. The study towards high intensity high charge state laser ion sources.

    Science.gov (United States)

    Zhao, H Y; Jin, Q Y; Sha, S; Zhang, J J; Li, Z M; Liu, W; Sun, L T; Zhang, X Z; Zhao, H W

    2014-02-01

    As one of the candidate ion sources for a planned project, the High Intensity heavy-ion Accelerator Facility, a laser ion source has been being intensively studied at the Institute of Modern Physics in the past two years. The charge state distributions of ions produced by irradiating a pulsed 3 J/8 ns Nd:YAG laser on solid targets of a wide range of elements (C, Al, Ti, Ni, Ag, Ta, and Pb) were measured with an electrostatic ion analyzer spectrometer, which indicates that highly charged ions could be generated from low-to-medium mass elements with the present laser system, while the charge state distributions for high mass elements were relatively low. The shot-to-shot stability of ion pulses was monitored with a Faraday cup for carbon target. The fluctuations within ±2.5% for the peak current and total charge and ±6% for pulse duration were demonstrated with the present setup of the laser ion source, the suppression of which is still possible.

  3. High intensity profile monitor for time resolved spectrometry at the CLIC Test Facility 3

    Science.gov (United States)

    Olvegård, M.; Adli, E.; Braun, H. H.; Bravin, E.; Chritin, N.; Corsini, R.; Dabrowski, A. E.; Döbert, S.; Dutriat, C.; Egger, D.; Lefèvre, T.; Mete, O.; Skowronski, P. K.; Tecker, F.

    2012-08-01

    The power source of the Compact LInear Collider (CLIC) relies on the generation and deceleration of a high-intensity electron drive beam. In order to provide the best radio-frequency (RF) to beam-energy transfer efficiency, the electron beam is accelerated using fully loaded RF cavities, which leads to strong beam loading effects resulting in a high-energy transient. The stability of the RF power produced by the drive beam depends on the stability of the drive beam energy and energy spread along the pulse. The control and the monitoring of the time evolution of the beam energy distribution are therefore crucial for the accelerator performance. For this purpose segmented beam dumps, which are simple and robust devices, have been designed and installed at the CLIC Test Facility 3 (CTF3). These devices are located at the end of spectrometer lines and provide horizontal beam profiles with a time resolution better than 10 ns. The segmented dumps are composed of parallel, vertical, metallic plates, and are based on the same principle as a Faraday cup: the impinging beam current is read by a fast acquisition channel. Both FLUKA and Geant4 simulations were performed to define the optimum detector geometry for beam energies ranging from 5 MeV to 150 MeV. This paper presents a detailed description of the different steps of the design: the optimization of the detector spatial resolution, the minimization of the thermal load and the long-term damage resulting from high radiation doses. Four segmented dumps are currently used in the CTF3 complex. Their measured performance and limitations are presented in this paper. Typical beam spectra as measured in the CTF3 linac are also presented along with a description of the RF manipulations needed for tuning the beam energy spectrum.

  4. The design and construction of a pulsed beam generation system based on high intensity cyclotron

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    In order to perform the studies on a pulsed beam generation system based on a high intensity cyclotron, a test beam line with a pulsed beam generation for a 10 MeV compact cyclotron (CYCIAE-10) has been designed and constructed at China Institute of Atomic Energy (CIAE). A 70 MHz continuous H- beam can be pulsed to the pulse length of less than 10 ns with a repetition rate of 4.4 MHz. The sine waveform with a frequency of 2.2 MHz is adopted for the chopper and a mesh structure with single drift and dual gaps is used for the 70 MHz buncher. A helical resonator is designed and constructed based on simulations and experiments on the RF matching for the chopper. A helical inductance loop that is exceptionally large of its kind and equipped with water cooling for the resonator has been successfully wound and a 500 W solid RF amplifier has been manufactured. A special measuring device has been designed, which can be used to measure both the DC beam and the pulsed beam. The required pulsed beam was obtained after pulsed beam tuning.

  5. Nakagami imaging for detecting thermal lesions induced by high-intensity focused ultrasound in tissue.

    Science.gov (United States)

    Rangraz, Parisa; Behnam, Hamid; Tavakkoli, Jahan

    2014-01-01

    High-intensity focused ultrasound induces focalized tissue coagulation by increasing the tissue temperature in a tight focal region. Several methods have been proposed to monitor high-intensity focused ultrasound-induced thermal lesions. Currently, ultrasound imaging techniques that are clinically used for monitoring high-intensity focused ultrasound treatment are standard pulse-echo B-mode ultrasound imaging, ultrasound temperature estimation, and elastography-based methods. On the contrary, the efficacy of two-dimensional Nakagami parametric imaging based on the distribution of the ultrasound backscattered signals to quantify properties of soft tissue has recently been evaluated. In this study, ultrasound radio frequency echo signals from ex vivo tissue samples were acquired before and after high-intensity focused ultrasound exposures and then their Nakagami parameter and scaling parameter of Nakagami distribution were estimated. These parameters were used to detect high-intensity focused ultrasound-induced thermal lesions. Also, the effects of changing the acoustic power of the high-intensity focused ultrasound transducer on the Nakagami parameters were studied. The results obtained suggest that the Nakagami distribution's scaling and Nakagami parameters can effectively be used to detect high-intensity focused ultrasound-induced thermal lesions in tissue ex vivo. These parameters can also be used to understand the degree of change in tissue caused by high-intensity focused ultrasound exposures, which could be interpreted as a measure of degree of variability in scatterer concentration in various parts of the high-intensity focused ultrasound lesion.

  6. High-intensity intermittent swimming improves cardiovascular health status for women with mild hypertension

    DEFF Research Database (Denmark)

    Mohr, Magni; Nordsborg, Nikolai Baastrup; Lindenskov, Annika;

    2014-01-01

    To test the hypothesis that high-intensity swim training improves cardiovascular health status in sedentary premenopausal women with mild hypertension, sixty-two women were randomized into high-intensity (n = 21; HIT), moderate-intensity (n = 21; MOD), and control groups (n = 20; CON). HIT...... high-intensity intermittent swimming is an effective training strategy to improve cardiovascular health and physical performance...... in sedentary women with mild hypertension. Adaptations are similar with high- and moderate-intensity training, despite markedly less total time spent and distance covered in the high-intensity group....

  7. H- Ion Sources for High Intensity Proton Drivers

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Rolland Paul; Dudnikov, Vadim

    2015-02-20

    Existing RF Surface Plasma Sources (SPS) for accelerators have specific efficiencies for H+ and H- ion generation around 3 to 5 mA/cm2 per kW, where about 50 kW of RF power is typically needed for 50 mA beam current production. The Saddle Antenna (SA) SPS described here was developed to improve H- ion production efficiency, reliability and availability for pulsed operation as used in the ORNL Spallation Neutron Source . At low RF power, the efficiency of positive ion generation in the plasma has been improved to 200 mA/cm2 per kW of RF power at 13.56 MHz. Initial cesiation of the SPS was performed by heating cesium chromate cartridges by discharge as was done in the very first versions of the SPS. A small oven to decompose cesium compounds and alloys was developed and tested. After cesiation, the current of negative ions to the collector was increased from 1 mA to 10 mA with RF power 1.5 kW in the plasma (6 mm diameter emission aperture) and up to 30 mA with 4 kW RF power in the plasma and 250 Gauss longitudinal magnetic field. The ratio of electron current to negative ion current was improved from 30 to 2. Stable generation of H- beam without intensity degradation was demonstrated in the aluminum nitride (AlN) discharge chamber for 32 days at high discharge power in an RF SPS with an external antenna. Some modifications were made to improve the cooling and cesiation stability. The extracted collector current can be increased significantly by optimizing the longitudinal magnetic field in the discharge chamber. While this project demonstrated the advantages of the pulsed version of the SA RF SPS as an upgrade to the ORNL Spallation Neutron Source, it led to a possibility for upgrades to CW machines like the many cyclotrons used for commercial applications. Four appendices contain important details of the work carried out under this grant.

  8. H- Ion Sources for High Intensity Proton Drivers

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Rolland Paul [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Dudnikov, Vadim [Muons, Inc., Batavia, IL (United States)

    2015-02-20

    Existing RF Surface Plasma Sources (SPS) for accelerators have specific efficiencies for H+ and H- ion generation around 3 to 5 mA/cm2 per kW, where about 50 kW of RF power is typically needed for 50 mA beam current production. The Saddle Antenna (SA) SPS described here was developed to improve H- ion production efficiency, reliability and availability for pulsed operation as used in the ORNL Spallation Neutron Source . At low RF power, the efficiency of positive ion generation in the plasma has been improved to 200 mA/cm2 per kW of RF power at 13.56 MHz. Initial cesiation of the SPS was performed by heating cesium chromate cartridges by discharge as was done in the very first versions of the SPS. A small oven to decompose cesium compounds and alloys was developed and tested. After cesiation, the current of negative ions to the collector was increased from 1 mA to 10 mA with RF power 1.5 kW in the plasma (6 mm diameter emission aperture) and up to 30 mA with 4 kW RF power in the plasma and 250 Gauss longitudinal magnetic field. The ratio of electron current to negative ion current was improved from 30 to 2. Stable generation of H- beam without intensity degradation was demonstrated in the aluminum nitride (AlN) discharge chamber for 32 days at high discharge power in an RF SPS with an external antenna. Some modifications were made to improve the cooling and cesiation stability. The extracted collector current can be increased significantly by optimizing the longitudinal magnetic field in the discharge chamber. While this project demonstrated the advantages of the pulsed version of the SA RF SPS as an upgrade to the ORNL Spallation Neutron Source, it led to a possibility for upgrades to CW machines like the many cyclotrons used for commercial applications. Four appendices contain important details of the work carried out under this grant.

  9. Nuclear Structure at the Legnaro National Laboratories:. from High Intensity Stable to Radioactive Nuclear Beams

    Science.gov (United States)

    de Angelis, G.

    2007-04-01

    To understand the properties of a nucleus, apart from establishing the interaction between its components, it is necessary to determine the arrangement of the nucleons, i.e. the structure of a nucleus. So far our knowledge about the structure of nuclei is mostly limited to nuclei close to the valley of stability, or nuclei with a deficiency of neutrons, which can be produced in fusion-evaporation reactions with stable beams and stable targets. Future perspectives in nuclear structure rely on radioactive ion beams (RIB) as well as on high intensity beams of stable ions (HISB). A world wide effort is presently going on in order to built the next generation radioactive ion beam facilities like the FAIR and the EURISOL projects. The LNL are contributing to such development through the design study of the EURISOL project as well as through the design and construction of the intermediate facility SPES. Concerning the instrumentation, particularly powerful is the combination of large acceptance spectrometers with highly segmented γ-detector arrays. An example is the CLARA γ-ray detector array coupled with the PRISMA spectrometer at the Legnaro National Laboratories (LNL). The physics aims achievable with such device complement studies performed with current radioactive beam (RIB) facilities. With this set-up we have recently investigated the stability of the N=50 shell closure. Here the comparison of the experimental data with shell model calculations seems to indicate a persistence of the N=50 shell gap down to Z=31. Also the study of proton rich nuclei can strongly benefit from the use of high intensity stable beams using fusion evaporation reactions at energies close to the Coulomb barrier. Future perspectives at LNL are based on an increase in intensity as well as on the availability of heavy ion species. Moreover a new ISOL facility (SPES) dedicated to the production and acceleration of radioactive neutron rich species is now under development at LNL. Among the new

  10. [Reflected high-intensity motion signals as markers of left ventricular diastolic dysfunction].

    Science.gov (United States)

    Makarenko, E S

    2013-01-01

    Reflected high-intensity signals of left ventricular motion can be used for assessment of diastolic function of left ventricle. There are many correlations between reflected high-intensity signals, transmitral flow, and tissue Doppler imaging parameters. Diagnostic criteria of LV diastolic dysfunction based on measurement of LV motion are suggested.

  11. The influence of basketball dribbling on repeated high-intensity intermittent runs

    Directory of Open Access Journals (Sweden)

    Zhaowei Kong

    2015-12-01

    Conclusion: The results suggest that the Yo-Yo IE2 test could reflect the repeatability of high-intensity intermittent basketball dribbling performance, while dribbling skills may have different influences on high-intensity intermittent exercise capacity in adolescent players at different ages.

  12. High Performance Human Face Recognition using Independent High Intensity Gabor Wavelet Responses: A Statistical Approach

    CERN Document Server

    Kar, Arindam; Basu, Dipak Kumar; Nasipuri, Mita; Kundu, Mahantapas

    2011-01-01

    In this paper, we present a technique by which high-intensity feature vectors extracted from the Gabor wavelet transformation of frontal face images, is combined together with Independent Component Analysis (ICA) for enhanced face recognition. Firstly, the high-intensity feature vectors are automatically extracted using the local characteristics of each individual face from the Gabor transformed images. Then ICA is applied on these locally extracted high-intensity feature vectors of the facial images to obtain the independent high intensity feature (IHIF) vectors. These IHIF forms the basis of the work. Finally, the image classification is done using these IHIF vectors, which are considered as representatives of the images. The importance behind implementing ICA along with the high-intensity features of Gabor wavelet transformation is twofold. On the one hand, selecting peaks of the Gabor transformed face images exhibit strong characteristics of spatial locality, scale, and orientation selectivity. Thus these...

  13. The Three Gorges Dam: Does it accelerate or delay the progress towards eliminating transmission of schistosomiasis in China?

    Science.gov (United States)

    Zhou, Yi-Biao; Liang, Song; Chen, Yue; Jiang, Qing-Wu

    2016-07-05

    The Three Gorges Dam, located in the largest endemic area of schistosomiasis in China, is one of the world's largest hydroelectric projects to date. Some large-scale hydro projects have resulted in schistosomiasis emergence or re-emergence. Therefore, the dam's potential impact on the transmission of Schistosoma japonicum has raised concerns from medical researchers worldwide. A systematic literature review, coupled with an analysis of data on the water level and snail density in the Yangtze River was conducted to assess the impact of the dam on schistosomiasis transmission after more than 10 years of operation. The dam has significantly altered the water levels in the Yangtze River according to different seasons. These changes directly impact the ecology of the schistosome snail host. Due to the dam, there has been a reduction in the density of Oncomelania snails and/or changes in the distribution of snails. The prevalence of infection with S. japonicum has decreased in the downstream areas of the dam, including in the Dongting and Poyang Lakes. The prevalence of infection with S. japonicum in humans has decreased from 6.80 % in 2002 (before the dam began operating) to 0.50 % in 2012, and the number of people infected with S. japonicum have decreased from 94 208 in 2002 to 59 200 in 2011 in the Poyang Lake region. The presence of the dam does not seem to affect snail breeding or the prevalence of schistosomiasis in the Three Gorges Reservoir. Overall, the Three Gorges Dam has significantly contributed to changes in hydrology after more than 10 years of the dam operating. The changes caused by the dam, together with integrated control of schistosomiasis, might be accelerating the progress towards eliminating the transmission of S. japonicum in the middle and lower reaches of the Yangtze River. Despite the positive effect the dam is having in controlling S. japonicum transmission, continued surveillance is required to monitor the future ecological impacts of the

  14. High-intensity fibre laser design for micro-machining applications

    Science.gov (United States)

    Ortiz-Neria, D. I.; Martinez-Piñón, F.; Hernandez-Escamilla, H.; Alvarez-Chavez, J. A.

    2010-11-01

    This work is focused on the design of a 250W high-intensity continuous-wave fibre optic laser with a 15μm spot size beam and a beam parameter product (BPP) of 1.8 for its use on Laser-assisted Cold Spray process (LCS) in the micro-machining areas. The metal-powder deposition process LCS, is a novel method based on Cold Spray technique (CS) assisted by laser technology. The LCS accelerates metal powders by the use of a high-pressure gas in order to achieve flash welding of particles over substrate. In LCS, the critical velocity of impact is lower with respect with CS while the powder particle is heated before the deposition by a laser beam. Furthermore, LCS does not heat the powder to achieve high temperatures as it happens in plasma processes. This property puts aside cooling problems which normally happen in sintered processes with high oxygen/nitrogen concentration levels. LCS will be used not only in deposition of thin layers. After careful design, proof of concept, experimental data, and prototype development, it should be feasible to perform micro-machining precise work with the use of the highintensity fibre laser presented in this work, and selective deposition of particles, in a similar way to the well-known Direct Metal Laser Sintering process (DMLS). The fibre laser consists on a large-mode area, Yb3+-doped, semi-diffraction limited, 25-m fibre laser cavity, operating in continuous wave regime. The fibre shows an arguably high slope-efficiency with no signs of roll-over. The measured M2 value is 1.8 and doping concentration of 15000ppm. It was made with a slight modification of the traditional MCVD technique. A full optical characterization will be presented.

  15. An integrated ultrasound-guided high intensity focused ultrasound system for in-vivo experiment

    Science.gov (United States)

    Liu, Dalong; Ebbini, Emad S.

    2017-03-01

    We present the system architecture of an integrated Ultrasound-guided High Intensity Focused Ultrasound (USgHIFU) system for image-guided surgery and temperature tracking in vivo. The system is capable of operating with multiple frontends. Current implementation has a SonixRP for imaging and a custom designed dual mode ultrasound array (DMUA) system (32Tx/32Rx) for imaging/therapy. The highlights of the system include a fully-programmable, multiple data stream capable data processing engine, and an arbitrarily programmable high power array driver that is able to synthesize complex beam patterns in space and time. The data processing engine features a pipeline-style design that can be programmed on-the-fly by re-arranging the pre-verified GPU-accelerated high performance pipeline blocks, which cover an extensive range from basic functions such as filtering to specialized processing like speckle tracking. Furthermore, the pipeline design also has the option of bringing in MATLAB (Mathworks, Natick, MA, US) as part of the processing chain, thus vastly increase the capability of the system. By properly balancing the processing load between GPU-enabled routine and MATLAB script. This allows one to achieve a high degree of flexibility while meeting real-time constraints. Results are presented from in vivo rat experiment. Where low dose of therapeutic ultrasound was delivered into the hind limb of the Copenhagen rats using DMUA and temperature was tracked using a linear probe (HST, Ultrasonix). The data is processed in realtime with MATLAB in the loop to perform temperature regularization. Results show that we can reliably track the low temperature heating in the presence of motion artifacts (respiration and pulsation).

  16. Maximal Sprint Power in Road Cyclists After Variable and Nonvariable High-Intensity Exercise.

    Science.gov (United States)

    Menaspà, Paolo; Martin, David T; Victor, James; Abbiss, Chris R

    2015-11-01

    This study compared the sprint performance of professional cyclists after 10 minutes of variable (VAR) or nonvariable (N-VAR) high-intensity cycling with sprint performance in a rested state. Ten internationally competitive male cyclists (mean ± SD: age, 20.1 ± 1.3 years; stature, 1.81 ± 0.07 m; body weight, 69.5 ± 4.9 kg; and V[Combining Dot Above]O2peak, 72.5 ± 4.4 ml·kg·min) performed a 12-second maximal sprint in 3 conditions: (a) a rested state, (b) after 10 minutes of N-VAR cycling, and (c) after 10 minutes of VAR cycling. The intensity during the 10-minute efforts gradually increased to replicate power output observed in the final section of cycling road races. During the VAR cycling, participants performed short (2 seconds) accelerations at 80% of their sprint peak power, every 30 seconds. Average power output, cadence, and maximal heart rate (HR) during the 10-minute efforts were similar between conditions (5.3 ± 0.2 W·kg, 102 ± 1 rpm, and 93 ± 3% HRmax). Postexercise blood lactate concentration and sessional perceived exertion were also similar (8.3 ± 1.6 mmol·L, 15.4 ± 1.3 [6-20 scale]). Peak and average power output and cadence during the subsequent maximal sprint were not different between the 3 experimental conditions (p > 0.05). In conclusion, this study showed that neither the VAR nor the N-VAR 10-minute efforts ridden in this study impaired sprint performance in elite competitive cyclists.

  17. Application of Projection Pursuit Evaluation Model Based on Real-Coded Accelerating Genetic Algorithm in Evaluating Wetland Soil Quality Variations in the Sanjiang Plain,China

    Institute of Scientific and Technical Information of China (English)

    FU QIANG; XIE YONGGANG; WEI ZIMIN

    2003-01-01

    A new technique of dimension reduction named projection pursuit is applied to model and evaluatewetland soil quality variations in the Sanjiang Plain, Helongjiang Province, China. By adopting the im-proved real-coded accelerating genetic algorithm (RAGA), the projection direction is optimized and multi-dimensional indexes are converted into low-dimensional space. Classification of wetland soils and evaluationof wetland soil quality variations are realized by pursuing optimum projection direction and projection func-tion value. Therefore, by adopting this new method, any possible human interference can be avoided andsound results can be achieved in researching quality changes and classification of wetland soils.

  18. Short-term effects of implemented high intensity shoulder elevation during computer work

    Directory of Open Access Journals (Sweden)

    Madeleine Pascal

    2009-08-01

    Full Text Available Abstract Background Work-site strength training sessions are shown effective to prevent and reduce neck-shoulder pain in computer workers, but difficult to integrate in normal working routines. A solution for avoiding neck-shoulder pain during computer work may be to implement high intensity voluntary contractions during the computer work. However, it is unknown how this may influence productivity, rate of perceived exertion (RPE as well as activity and rest of neck-shoulder muscles during computer work. The aim of this study was to investigate short-term effects of a high intensity contraction on productivity, RPE and upper trapezius activity and rest during computer work and a subsequent pause from computer work. Methods 18 female computer workers performed 2 sessions of 15 min standardized computer mouse work preceded by 1 min pause with and without prior high intensity contraction of shoulder elevation. RPE was reported, productivity (drawings per min measured, and bipolar surface electromyography (EMG recorded from the dominant upper trapezius during pauses and sessions of computer work. Repeated measure ANOVA with Bonferroni corrected post-hoc tests was applied for the statistical analyses. Results The main findings were that a high intensity shoulder elevation did not modify RPE, productivity or EMG activity of the upper trapezius during the subsequent pause and computer work. However, the high intensity contraction reduced the relative rest time of the uppermost (clavicular trapezius part during the subsequent pause from computer work (p Conclusion Since a preceding high intensity shoulder elevation did not impose a negative impact on perceived effort, productivity or upper trapezius activity during computer work, implementation of high intensity contraction during computer work to prevent neck-shoulder pain may be possible without affecting the working routines. However, the unexpected reduction in clavicular trapezius rest during a

  19. The high intensity solar cell: Key to low cost photovoltaic power

    Science.gov (United States)

    Sater, B. L.; Goradia, C.

    1975-01-01

    The design considerations and performance characteristics of the 'high intensity' (HI) solar cell are presented. A high intensity solar system was analyzed to determine its cost effectiveness and to assess the benefits of further improving HI cell efficiency. It is shown that residential sized systems can be produced at less than $1000/kW peak electric power. Due to their superior high intensity performance characteristics compared to the conventional and VMJ cells, HI cells and light concentrators may be the key to low cost photovoltaic power.

  20. Beam-Induced Effects and Radiological Issues in High-Intensity High-Energy Fixed Target Experiments

    CERN Document Server

    Mokhov, N V; Drozhdin, A I; Pronskikh, V S; Reitzner, D; Tropin, I S; Vaziri, K

    2014-01-01

    The next generation of accelerators for Megawatt proton and heavy-ion beams moves us into a completely new domain of extreme specific energies of up to 0.1 MJ/g (Megajoule/gram) and specific power up to 1 TW/g (Terawatt/gram) in beam interactions with matter. This paper is focused on deleterious effects of controlled and uncontrolled impacts of high-intensity beams on components of beam-lines, target stations, beam absorbers, shielding and environment. Two new experiments at Fermilab are taken as an example. The Long-Baseline Neutrino Experiment (LBNE) will explore the interactions and transformations of the world's highest-intensity neutrino beam by sending it from Fermilab more than 1,000 kilometers through the Earth's mantle to a large liquid argon detector. The Mu2e experiment is devoted to studies of the conversion of a negative muon to electron in the field of a nucleus without emission of neutrinos.

  1. Evolution of High Intensity Beams in the CERN PS Booster after H⁻ Injection and Phase Space Painting

    CERN Document Server

    Cieslak-Kowalska, Magdalena; Benedetto, Elena; Bracco, Chiara

    2016-01-01

    With the LHC Injector Upgrade (LIU) project, the injection energy of PS Booster (PSB) ' first circular accelerator in the LHC injector chain ' will be raised from 50 MeV to 160 MeV and the present multiturn injection will be upgraded to H⁻ injection with transverse and longitudinal painting. In the scope of this project, it is planned to double the beam intensities, profiting from the fact that the βγ2 factor will be two times larger (0.35 at 50 MeV and 0.71 at 160 MeV), so the resulting tune spread driven by a direct space charge should remain similar. This paper describes the feasibility to double the intensity of high intensity and large emittance beams, looking into the evolution under space charge and taking into account losses constrains in the ring and in the extraction lines.

  2. Effect of preseason concurrent muscular strength and high-intensity interval training in professional soccer players.

    Science.gov (United States)

    Wong, Pui-lam; Chaouachi, Anis; Chamari, Karim; Dellal, Alexandre; Wisloff, Ulrik

    2010-03-01

    This study examined the effect of concurrent muscular strength and high-intensity running interval training on professional soccer players' explosive performances and aerobic endurance. Thirty-nine players participated in the study, where both the experimental group (EG, n = 20) and control group (CG, n = 19) participated in 8 weeks of regular soccer training, with the EG receiving additional muscular strength and high-intensity interval training twice per week throughout. Muscular strength training consisted of 4 sets of 6RM (repetition maximum) of high-pull, jump squat, bench press, back half squat, and chin-up exercises. The high-intensity interval training consisted of 16 intervals each of 15-second sprints at 120% of individual maximal aerobic speed interspersed with 15 seconds of rest. EG significantly increased (p aerobic speed test, and maximal aerobic speed. High-intensity interval running can be concurrently performed with high load muscular strength training to enhance soccer players' explosive performances and aerobic endurance.

  3. Extremely short duration high intensity interval training substantially improves insulin action in young healthy males

    DEFF Research Database (Denmark)

    Babraj, John A; Vollaard, Niels B J; Keast, Cameron

    2009-01-01

    BACKGROUND: Traditional high volume aerobic exercise training reduces cardiovascular and metabolic disease risk but involves a substantial time commitment. Extremely low volume high-intensity interval training (HIT) has recently been demonstrated to produce improvements to aerobic function, but i...

  4. High-intensity focused ultrasound treatment of abnormal vaginal bleeding secondary to uterine myoma.

    Science.gov (United States)

    Lim, Jung Hyun; Chung, Dong Jin; Lim, Young Tec; Cho, Sae Hyun; Lee, Jae Mun; Hahn, Seong-Tae

    2011-03-01

    We describe the use of high-intensity focused ultrasound for acute vaginal bleeding secondary to uterine myoma in 2 young female patients. Both patients had episodes of abnormal vaginal bleeding with severe dysmenorrhea that was not efficiently controlled by medical treatment. After high-intensity focused ultrasound ablation, both vaginal bleeding control and symptom relief were achieved without postinterventional complications. The patients remained free of symptoms during 2 months of follow-up and regained normal menstruation after high-intensity focused ultrasound therapy. High-intensity focused ultrasound treatment is one of the least invasive options for dysfunctional vaginal bleeding and may be an effective and safe alternative to other procedures in women of reproductive age with abnormal vaginal bleeding secondary to uterine myoma.

  5. High-Intensity Intermittent Exercise: Effect on Young People's Cardiometabolic Health and Cognition.

    Science.gov (United States)

    Cooper, Simon B; Dring, Karah J; Nevill, Mary E

    2016-01-01

    With only a quarter of young people currently meeting physical activity guidelines, two key areas of concern are the effects of exercise on cardiometabolic health and cognition. Despite the fact that physical activity in young people is typically high intensity and intermittent in nature, much of the literature examines traditional endurance-type exercise. This review provides an update on the effects of high-intensity intermittent exercise on young people's cardiometabolic health and cognition. High-intensity intermittent exercise has acute beneficial effects on endothelial function and postprandial lipemia and chronic positive effects on weight management. In addition, there is emerging evidence regarding chronic benefits on the blood lipid profile, blood pressure, and proinflammatory and anti-inflammatory cytokines. Furthermore, emerging evidence suggests beneficial acute and chronic effects of high-intensity intermittent exercise on cognition. However, further research is required in both cardiometabolic health and cognition, particularly regarding the impact of school-based interventions in adolescents.

  6. High intensity proton beam transportation through fringe field of 70 MeV compact cyclotron to beam line targets

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Xu, E-mail: emmazhang103@gmail.com [China Institute of Atomic Energy (China); Li, Ming; Wei, Sumin; Xing, Jiansheng; Hu, Yueming [China Institute of Atomic Energy (China); Johnson, Richard R.; Piazza, Leandro; Ryjkov, Vladimir [BEST Cyclotron Inc (Canada)

    2016-06-01

    From the stripping points, the high intensity proton beam of a compact cyclotron travels through the fringe field area of the machine to the combination magnet. Starting from there the beams with various energy is transferred to the switching magnet for distribution to the beam line targets. In the design of the extraction and transport system for the compact proton cyclotron facilities, such as the 70 MeV in France and the 100 MeV in China, the space charge effect as the beam crosses the fringe field has not been previously considered; neither has the impact on transverse beam envelope coupled from the longitudinal direction. Those have been concerned much more with the higher beam-power because of the beam loss problem. In this paper, based on the mapping data of 70 MeV cyclotron including the fringe field by BEST Cyclotron Inc (BEST) and combination magnet field by China Institute of Atomic Energy (CIAE), the beam extraction and transport are investigated for the 70 MeV cyclotron used on the SPES project at Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro (INFN–LNL). The study includes the space charge effect and longitudinal and transverse coupling mentioned above, as well as the matching of beam optics using the beam line for medical isotope production as an example. In addition, the designs of the ±45° switching magnets and the 60° bending magnet for the extracted beam with the energy from 35 MeV to 70 MeV have been made. Parts of the construction and field measurements of those magnets have been done as well. The current result shows that, the design considers the complexity of the compact cyclotron extraction area and fits the requirements of the extraction and transport for high intensity proton beam, especially at mA intensity levels.

  7. High intensity proton beam transportation through fringe field of 70 MeV compact cyclotron to beam line targets

    Science.gov (United States)

    Zhang, Xu; Li, Ming; Wei, Sumin; Xing, Jiansheng; Hu, Yueming; Johnson, Richard R.; Piazza, Leandro; Ryjkov, Vladimir

    2016-06-01

    From the stripping points, the high intensity proton beam of a compact cyclotron travels through the fringe field area of the machine to the combination magnet. Starting from there the beams with various energy is transferred to the switching magnet for distribution to the beam line targets. In the design of the extraction and transport system for the compact proton cyclotron facilities, such as the 70 MeV in France and the 100 MeV in China, the space charge effect as the beam crosses the fringe field has not been previously considered; neither has the impact on transverse beam envelope coupled from the longitudinal direction. Those have been concerned much more with the higher beam-power because of the beam loss problem. In this paper, based on the mapping data of 70 MeV cyclotron including the fringe field by BEST Cyclotron Inc (BEST) and combination magnet field by China Institute of Atomic Energy (CIAE), the beam extraction and transport are investigated for the 70 MeV cyclotron used on the SPES project at Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro (INFN-LNL). The study includes the space charge effect and longitudinal and transverse coupling mentioned above, as well as the matching of beam optics using the beam line for medical isotope production as an example. In addition, the designs of the ±45° switching magnets and the 60° bending magnet for the extracted beam with the energy from 35 MeV to 70 MeV have been made. Parts of the construction and field measurements of those magnets have been done as well. The current result shows that, the design considers the complexity of the compact cyclotron extraction area and fits the requirements of the extraction and transport for high intensity proton beam, especially at mA intensity levels.

  8. Dynamics of Cavitation Clouds within a High-Intensity Focused Ultrasonic Beam

    Science.gov (United States)

    2012-03-01

    the cloud size. I. INTRODUCTION High-intensity focused ultrasound (HIFU), along with the associated cavitation , is used in a variety of fields. The...Article 3. DATES COVERED (From - To) March 2012- May 2012 4. TITLE AND SUBTITLE Dynamics of Cavitation Clouds within a High-Intensity Focused...in initially quiescent water. The resulting pressure field and behavior of the cavitation bubbles are measured using high-speed digital in-line

  9. Target Surface Area Effects on Hot Electron Dynamics from High Intensity Laser-Plasma Interactions

    Science.gov (United States)

    2016-08-19

    New J. Phys. 18 (2016) 063020 doi:10.1088/1367-2630/18/6/063020 PAPER Target surface area effects on hot electron dynamics from high intensity laser ...Science, University ofMichigan, AnnArbor,MI 48109-2099, USA E-mail: czulick@umich.edu Keywords: laser -plasma,mass-limited, fast electrons, sheath...field Abstract Reduced surface area targets were studied using an ultra-high intensity femtosecond laser in order to determine the effect of electron

  10. Design and implementation of capacitive micromachined ultrasonic transducers for high intensity focused ultrasound

    OpenAIRE

    Yamaner, Yalçın Feysel; Yamaner, Yalcin Feysel

    2011-01-01

    High intensity focused ultrasound (HIFU) is a medical procedure for noninvasive treatment of cancers. High intensity focused ultrasound is used to heat and destroy the diseased tissue. Piezoelectricity has been the core mechanism for generation of ultrasound waves in the treatment. Focusing can be done by using spherically curved transducers or using a lens or electronically steering sound waves by using phased arrays. Current research in HIFU technology targets the development of MR-guided m...

  11. High-intensity training reduces CD8+ T-cell redistribution in response to exercise

    NARCIS (Netherlands)

    Witard, O.C.; Turner, J.E.; Jackman, S.R.; Tipton, K.D.; Jeukendrup, A.E.; Kies, A.K.; Bosch, J.A.

    2012-01-01

    Purpose: We examined whether exercise-induced lymphocytosis and lymphocytopenia are impaired with high-intensity training. Methods: Eight trained cyclists (V·O2max = 64.2 ± 6.5 mL·kg-1·min-1) undertook 1 wk of normal-intensity training and a second week of high-intensity training. On day 7 of each w

  12. Anthropometric, Sprint, and High-Intensity Running Profiles of English Academy Rugby Union Players by Position.

    Science.gov (United States)

    Darrall-Jones, Joshua D; Jones, Ben; Till, Kevin

    2016-05-01

    The purpose of this study was to evaluate the anthropometric, sprint, and high-intensity running profiles of English academy rugby union players by playing positions, and to investigate the relationships between anthropometric, sprint, and high-intensity running characteristics. Data were collected from 67 academy players after the off-season period and consisted of anthropometric (height, body mass, sum of 8 skinfolds [∑SF]), 40-m linear sprint (5-, 10-, 20-, and 40-m splits), the Yo-Yo intermittent recovery test level 1 (Yo-Yo IRTL-1), and the 30-15 intermittent fitness test (30-15 IFT). Forwards displayed greater stature, body mass, and ∑SF; sprint times and sprint momentum, with lower high-intensity running ability and sprint velocities than backs. Comparisons between age categories demonstrated body mass and sprint momentum to have the largest differences at consecutive age categories for forwards and backs; whereas 20-40-m sprint velocity was discriminate for forwards between under 16s, 18s, and 21s. Relationships between anthropometric, sprint velocity, momentum, and high-intensity running ability demonstrated body mass to negatively impact on sprint velocity (10 m; r = -0.34 to -0.46) and positively affect sprint momentum (e.g., 5 m; r = 0.85-0.93), with large to very large negative relationships with the Yo-Yo IRTL-1 (r = -0.65 to -0.74) and 30-15 IFT (r = -0.59 to -0.79). These findings suggest that there are distinct anthropometric, sprint, and high-intensity running ability differences between and within positions in junior rugby union players. The development of sprint and high-intensity running ability may be impacted by continued increases in body mass as there seems to be a trade-off between momentum, velocity, and the ability to complete high-intensity running.

  13. Phase-shift nano-emulsions induced cavitation and ablation during high intensity focused ultrasound exposure

    Science.gov (United States)

    Qiao, Yangzi; Yin, Hui; Chang, Nan; Wan, Mingxi

    2017-03-01

    Phase-shift Nano-emulsions (PSNEs) with a small initial diameter in nanoscale have the potential to leak out of the blood vessels and to accumulate at target point of tissue. At desired location, PSNEs can undergo acoustic droplet vaporization (ADV) process, change into gas bubbles and enhance focused ultrasound efficiency. The aim of this work was to provide spatial and temporal information on PSNE induced cavitation and ablation effects during pulsed high intensity focused ultrasound (HIFU) exposure. The PSNEs were composed of perfluorohaxane (PFH) and bovine serum albumin (BSA), and then uniformly distributed in a transparent polyacrylamide phantom. The Sonoluminescence (SL) method was employed to visualize the cavitation distribution and formation process of PSNEs induced cavitation. For the phantom which was used for ablation observation, heat sensitive BSA was added. When the temperature generated by ultrasound exposure was high enough to denature BSA, the transparent phantom would turn out white lesions. The shape of the lesion and the formation process were compared with those of cavitation. Each of the pulse contained 12 cycles for a duration of 10 µs. And the duty cycle changed from 1:10 to 1:40. The total "on" time of HIFU was 2s. PSNE can evidently accelerate cavitation emitting bright SL in pre-focal region. The cavitation was generated layer by layer towards the transducer. The formed bubble wall can block acoustic waves transmitting to the distal end. And the lesion appeared to be separated into two parts. One in pre-focal region stemmed from one point and grew quickly toward the transducer. The other in focal region was formed by merging some small white dots, and grew much slower. The influence of duty cycle has also been examined. The lower duty cycle with longer pulse-off time would generate more intense cavitation, however, smaller lesion. Bubble cloud gradually developed within phantom would greatly influence the cavitation and ablation

  14. Beam acceleration through proton radio frequency quadrupole accelerator in BARC

    Science.gov (United States)

    Bhagwat, P. V.; Krishnagopal, S.; Mathew, J. V.; Singh, S. K.; Jain, P.; Rao, S. V. L. S.; Pande, M.; Kumar, R.; Roychowdhury, P.; Kelwani, H.; Rama Rao, B. V.; Gupta, S. K.; Agarwal, A.; Kukreti, B. M.; Singh, P.

    2016-05-01

    A 3 MeV proton Radio Frequency Quadrupole (RFQ) accelerator has been designed at the Bhabha Atomic Research Centre, Mumbai, India, for the Low Energy High Intensity Proton Accelerator (LEHIPA) programme. The 352 MHz RFQ is built in 4 segments and in the first phase two segments of the LEHIPA RFQ were commissioned, accelerating a 50 keV, 1 mA pulsed proton beam from the ion source, to an energy of 1.24 MeV. The successful operation of the RFQ gave confidence in the physics understanding and technology development that have been achieved, and indicate that the road forward can now be traversed rather more quickly.

  15. High-intensity intermittent swimming improves cardiovascular health status for women with mild hypertension

    DEFF Research Database (Denmark)

    Mohr, Magni; Nordsborg, Nikolai Baastrup; Lindenskov, Annika

    2014-01-01

    To test the hypothesis that high-intensity swim training improves cardiovascular health status in sedentary premenopausal women with mild hypertension, sixty-two women were randomized into high-intensity (n = 21; HIT), moderate-intensity (n = 21; MOD), and control groups (n = 20; CON). HIT...... swim (13 ± 3% and 22 ± 3%), interval swimming (23 ± 3% and 8 ± 3%), and Yo-Yo IE1 running performance (58 ± 5% and 45 ± 4%). In conclusion, high-intensity intermittent swimming is an effective training strategy to improve cardiovascular health and physical performance...... performed 6-10 × 30 s all-out swimming interspersed by 2 min recovery and MOD swam continuously for 1 h at moderate intensity for a 15-week period completing in total 44 ± 1 and 43 ± 1 sessions, respectively. In CON, all measured variables were similar before and after the intervention period. Systolic BP...

  16. High-intensity intermittent swimming improves cardiovascular health status for women with mild hypertension

    DEFF Research Database (Denmark)

    Mohr, Magni; Nordsborg, Nikolai Baastrup; Lindenskov, Annika;

    2014-01-01

    To test the hypothesis that high-intensity swim training improves cardiovascular health status in sedentary premenopausal women with mild hypertension, sixty-two women were randomized into high-intensity (n = 21; HIT), moderate-intensity (n = 21; MOD), and control groups (n = 20; CON). HIT...... performed 6-10 × 30 s all-out swimming interspersed by 2 min recovery and MOD swam continuously for 1 h at moderate intensity for a 15-week period completing in total 44 ± 1 and 43 ± 1 sessions, respectively. In CON, all measured variables were similar before and after the intervention period. Systolic BP...... swim (13 ± 3% and 22 ± 3%), interval swimming (23 ± 3% and 8 ± 3%), and Yo-Yo IE1 running performance (58 ± 5% and 45 ± 4%). In conclusion, high-intensity intermittent swimming is an effective training strategy to improve cardiovascular health and physical performance...

  17. Repeated high-intensity exercise modulates Ca(2+) sensitivity of human skeletal muscle fibers

    DEFF Research Database (Denmark)

    Gejl, K D; Hvid, L G; Willis, S J;

    2016-01-01

    The effects of short-term high-intensity exercise on single fiber contractile function in humans are unknown. Therefore, the purposes of this study were: (a) to access the acute effects of repeated high-intensity exercise on human single muscle fiber contractile function; and (b) to examine whether...... the fourth sprint with respect to Ca(2+) sensitivity and maximal Ca(2+) -activated force. To investigate the oxidative effects of exercise on single fiber contractile function, a subset of fibers was incubated with dithiothreitol (DTT) before analysis. Ca(2+) sensitivity was enhanced by exercise in both MHC...... I (17%, P exercise. In conclusion, repeated high-intensity exercise increased Ca(2+) sensitivity in both MHC I and MHC II...

  18. The high intensity solar cell - Key to low cost photovoltaic power

    Science.gov (United States)

    Sater, B. L.; Goradia, C.

    1975-01-01

    This paper discusses the problems associated with conventional solar cells at high intensities and presents the design considerations and performance characteristics of the 'high intensity' (HI) solar cell which appears to eliminate the major problems. Test data obtained at greater than 250 AM1 suns gave a peak output power density of 2 W per sq cm at an efficiency exceeding 6% with an unoptimized cell operating at over 100 C. It appears that operation at 1000 AM1 suns at efficiencies greater than 10% is possible. At 1000 AM1 suns and 10% efficiency, the HI cell manufacturing cost is estimated to be $0.25/watt, with multi-megawatt annual production capability already existing within the industrial sector. A high intensity solar system was also analyzed to determine its cost effectiveness and to assess the benefits of further improving HI cell efficiency.

  19. Observation of fine particle aggregating behavior induced by high intensity conditioning using high speed CCD

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    The aggregating behavior between bubbles and particles induced by high intensity conditioning (HIC) was studied using high speed CCD technique. Bubble size measurement was conducted, and the attachment behavior between bubbles and particles in HIC cell and flotation cell were observed. The results show that in HIC cell, high intensity conditioning creates an advantage environment for the formation of small size bubble due to hydrodynamic cavitations, and these fine bubbles have high probability of bubble-particle collision,which will enhance fine particle flotation. The bubble-particle attachment experiments indicate that in high intensity conditioning cell, a lot of fine bubbles are produced in situ on the surface of fine particles, and most of fine particles are aggregated under the bridging action of fine bubbles. The observation of bubble-particle interaction in flotation cell illustrates that aggregates created by HIC can be loaded more easily by big air bubble in flotation cell than those created by normal conditioning.

  20. Changes in satellite cells in human skeletal muscle after a single bout of high intensity exercise

    DEFF Research Database (Denmark)

    Crameri, Regina M; Langberg, Henning; Magnusson, Peter

    2004-01-01

    desmin or dystrophin, were not observed, and hence did not appear to induce the expression of either N-CAM or FA1. We therefore propose that satellite cells can be induced to re-enter the cell growth cycle after a single bout of unaccustomed high intensity exercise. However, a single bout of exercise......No studies to date have reported activation of satellite cells in vivo in human muscle after a single bout of high intensity exercise. In this investigation, eight individuals performed a single bout of high intensity exercise with one leg, the contralateral leg being the control. A significant...... increase in mononuclear cells staining for the neural cell adhesion molecule (N-CAM) and fetal antigen 1 (FA1) were observed within the exercised human vastus lateralis muscle on days 4 and 8 post exercise. In addition, a significant increase in the concentration of the FA1 protein was determined...

  1. The clinical study on high intensity zone of magnetic resonance imaging using Scolopendrid Aquacupuncture.

    Directory of Open Access Journals (Sweden)

    Jeong-a Lim

    2006-12-01

    Full Text Available Objective : This study was designed to find out the effect of scolopendrid aquacupuncture on low back pain with or without sciatica showing high intensity zone of magnetic resonance imaging. Methods : The 30 patients who had a diagnosis of high intensity zone by lumbar-MRI and admitted to Gwangju oriental medical hospital in wonkwang university from January 2005 to August 2004 were observed. The symptom of inpatients is low back pain with or without sciatica. We treated 30 patients by scolopendrid aquacupuncture besides the general conservative treatment of oriental medicine. Results and Conclusion : The scolopendrid aquacupuncture treatment led to improvement in the pain and symptom of disability as determined by all efficacy measures. After scolopendrid aquacupuncture treatment, there was improvement in VAS, ROM and SLRT. This results suggest that scolopendrid aquacupuncture is good method for treatment of low back pain with or without sciatica showing high intensity zone of magnetic resonance imaging.

  2. Formation of Nanoscale Intermetallic Phases in Ni Surface Layer at High Intensity Implantation of Al Ions

    Institute of Scientific and Technical Information of China (English)

    I.A.Bozhko; S.V.Fortuna; I.A.Kurzina; I.B.Stepanov; E.V.Kozlov; Yu.P. Sharkeev

    2004-01-01

    The results of experimental study of nanoscale intermetallic formation in surface layer of a metal target at ion implantation are presented. To increase the thickness of the ion implanted surface layer the high intensive ion implantation is used. Compared with the ordinary ion implantation, the high intensive ion implantation allows a much thicker modified surface layer. Pure polycrystalline nickel was chosen as a target. Nickel samples were irradiated with Al ions on the vacuum-arc ion beam and plasma flow source "Raduga-5". It was shown that at the high intensity ion implantation the fine dispersed particles of Ni3Al, NiAl intermetallic compounds and solid solution Al in Ni are formed in the nickel surface layer of 200 nm and thicker. The formation of phases takes place in complete correspondence with the Ni-Al phase diagram.

  3. 2014 Joint International Accelerator School: Beam Loss and Accelerator Protection

    CERN Document Server

    JAS - Joint US-CERN-Japan-Russia Accelerator School

    2016-01-01

    Many particle accelerators operate with very high beam power and very high energy stored in particle beams as well as in magnet systems. In the future, the beam power in high intensity accelerators will further increase. The protection of the accelerator equipment from the consequences of uncontrolled release of the energy is essential. This was the motivation for organizing a first school on beam losses and accelerator protection (in general referred to as machine protection). During the school the methods and technologies to identify, mitigate, monitor and manage the technical risks associated with the operation of accelerators with high-power beams or subsystems with large stored energy were presented. At the completion of the school the participants should have been able to understand the physical phenomena that can damage machine subsystems or interrupt operations and to analyze an accelerator facility to produce a register of technical risks and the corresponding risk mitigation and management strategie...

  4. Stretching Effects: High-intensity & Moderate-duration vs. Low-intensity & Long-duration.

    Science.gov (United States)

    Freitas, S R; Vaz, J R; Bruno, P M; Andrade, R; Mil-Homens, P

    2016-03-01

    This study examined whether a high-intensity, moderate-duration bout of stretching would produce the same acute effects as a low-intensity, long-duration bout of stretching. 17 volunteers performed 2 knee-flexor stretching protocols: a high-intensity stretch (i. e., 100% of maximum tolerable passive torque) with a moderate duration (243.5 ± 69.5-s); and a low-intensity stretch (50% of tolerable passive torque) with a long duration (900-s). Passive torque at a given sub-maximal angle, peak passive torque, maximal range of motion (ROM), and muscle activity were assessed before and after each stretching protocol (at intervals of 1, 30 and 60 min). The maximal ROM and tolerable passive torque increased for all time points following the high-intensity stretching (p0.05). 1 min post-stretching, the passive torque decreased in both protocols, but to a greater extent in the low-intensity protocol. 30 min post-test, torque returned to baseline for the low-intensity protocol and had increased above the baseline for the high-intensity stretches. The following can be concluded: 1) High-intensity stretching increases the maximal ROM and peak passive torque compared to low-intensity stretching; 2) low-intensity, long-duration stretching is the best way to acutely decrease passive torque; and 3) high-intensity, moderate-duration stretching increases passive torque above the baseline 30 min after stretching.

  5. High-intensity running in English FA Premier League soccer matches

    DEFF Research Database (Denmark)

    Bradley, Paul S.; Sheldon, William; Wooster, Blake

    2009-01-01

    The aims of this study were to (1) determine the activity profiles of a large sample of English FA Premier League soccer players and (2) examine high-intensity running during elite-standard soccer matches for players in various playing positions. Twenty-eight English FA Premier League games were...... with and without ball possession is reduced during various phases of elite-standard soccer matches and the activity profiles and fatigue patterns vary among playing positions. The current findings provide valuable information about the high-intensity running patterns of a large sample of elite-standard soccer...

  6. The miniature accelerator

    CERN Multimedia

    Antonella Del Rosso

    2015-01-01

    The image that most people have of CERN is of its enormous accelerators and their capacity to accelerate particles to extremely high energies. But thanks to some cutting-edge studies on beam dynamics and radiofrequency technology, along with innovative construction techniques, teams at CERN have now created the first module of a brand-new accelerator, which will be just 2 metres long. The potential uses of this miniature accelerator will include deployment in hospitals for the production of medical isotopes and the treatment of cancer. It’s a real David-and-Goliath story.   Serge Mathot, in charge of the construction of the "mini-RFQ", pictured with the first of the four modules that will make up the miniature accelerator. The miniature accelerator consists of a radiofrequency quadrupole (RFQ), a component found at the start of all proton accelerator chains around the world, from the smallest to the largest. The LHC is designed to produce very high-intensity beams ...

  7. 加快我国远洋渔业发展的对策选择%On the Countermeasures of Accelerating the Distant Water Fishery in China

    Institute of Scientific and Technical Information of China (English)

    李嘉晓

    2015-01-01

    远洋渔业是我国海洋渔业重点发展产业之一, 也是"海洋强国" 战略的落脚点之一. 从船队规模、 产量产值和国际地位三个角度描述我国远洋渔业发展现状后, 从资源、 技术、 人力等方面, 深入剖析了我国远洋渔业发展的主要制约因素, 进而提出了促进我国远洋渔业产业发展的对策建议.%The distant water fishery is one of the key industries of marine fishery. It is one of the ultimate goal of "maritime power" strategy. The paper describes the development status of the distant water fishery from three perspectives:the size of the fleet, output value and the international status. Then, from the aspects of resources, technology, human and others, the paper deeply analyzes the main restricting factors of the distant water fishery in China. In the end, it puts forward the countermeasures to accelerate the distant water fishery in China.

  8. 'Train-the-Trainer': an effective and successful model to accelerate training and improve physiotherapy services for persons with haemophilia in China.

    Science.gov (United States)

    Chen, L; Sun, J; Hilliard, P; Zourikian, N; Hang, M; Blanchette, V; Poon, M C; Luke, K

    2014-05-01

    The objective of this study was to teach a small group of Chinese physiatrists and physiotherapists to: (i) become trainers and leaders in haemophilia physiotherapy (PT) care in China and (ii) to acquire rapid proficiency in using the reliable and validated Hemophilia Joint Health Score (HJHS) for evaluating musculoskeletal health in boys with haemophilia. Two experienced Canadian physiotherapists and co-developers of the HJHS moderated a 4-day PT training workshop with six Chinese participants. Emphasis was placed on instruction and practice in administering the HJHS. Practical sessions with haemophilia patients were interchanged with theory (power point presentations) and interactive question and answer periods. A proficient, knowledgeable translator was an essential component of the workshop. Upon workshop completion, the six trainees demonstrated improved haemophilia-specific PT knowledge and were fully familiar with the HJHS and its administration. The latter was assessed in a mini-reliability study. The 'Train-the-Trainer' model is a very effective education programme designed to accelerate training in haemophilia PT to meet the rapidly increasing need for haemophilia-specific rehabilitation services in a very large country such as China. It is anticipated that physiatrists/physiotherapists at newly established Chinese haemophilia treatment centres will receive training in haemophilia care as a result of this unique programme in the immediate future.

  9. Productions of hollow atoms from solids irradiated by high intensity laser

    Energy Technology Data Exchange (ETDEWEB)

    Moribayashi, K.; Sasaki, A.; Zhidkov, A. [Advanced Photon Research Center, Kansai Research Establishment, Japan Atomic Energy Research Inst. (Japan)

    2001-07-01

    The production of hollow atoms through the collisions of fast electrons with a solid is studied. These electrons are produced by high-intensity short-pulse laser irradiation on a solid. The inner-shell ionization and excitation processes by the fast electron impact are investigated. It is found that ionization processes give more significant contribution to the production of hollow atoms. (orig.)

  10. Non-Thermal High-Intensity Focused Ultrasound for Breast Cancer Therapy

    Science.gov (United States)

    2013-07-01

    Comet assay reveals DNA strand breaks induced by ultrasonic cavitation in vitro, Ultrasound in medicine & biology 1995; 21: 841-8. 3. Dalecki D...doxorubicin, focused ultrasound , HIFU, prostate cancer I. INTRODUCTION Pulsed high-intensity focused ultrasound (pFUS) is able to create acoustic cavitation ... ultrasound for breast cancer therapy PRINCIPAL INVESTIGATOR: Chang Ming (Charlie) Ma, Ph.D

  11. 21 CFR 1040.30 - High-intensity mercury vapor discharge lamps.

    Science.gov (United States)

    2010-04-01

    ... mercury and that is contained within an outer envelope. (2) Advertisement means any catalog, specification... ballast is an inductive reactor designed to have the operating characteristics as listed in Section 7 in... advertisement. Advertising for any high-intensity mercury vapor discharge lamp that does not comply...

  12. Towards MR-guided high intensity focused ultrasound ablation of liver tumors

    NARCIS (Netherlands)

    Wijlemans, J.W.

    2015-01-01

    Magnetic Resonance-guided High Intensity Focused Ultrasound (MR-HIFU) is a promising technique which can be used for completely non-invasive tissue ablation. The converging ultrasound beam penetrates the skin and subcutaneous tissues with damage, while heating the tissue only in the focal point. The

  13. MRI-guided High-Intensity Focused Ultrasound of Breast Cancer

    NARCIS (Netherlands)

    Merckel, L.G.

    2014-01-01

    Magnetic resonance imaging-guided high-intensity focused ultrasound (MR-HIFU) is a promising technique for completely noninvasive tumor ablation. This thesis focuses on its application for the treatment of patients with breast cancer. The first part of the thesis describes the role of breast MRI for

  14. Status of High Intensity Polarized Electron Gun at Mit-Bates

    Science.gov (United States)

    Tsentalovich, E.; Bessuille, J.; Tiunov, M.

    2011-01-01

    MIT-Bates, in collaboration with BNL, has developed a high intensity polarized electron gun for the eRHIC project. The gun implements large area cathode, ring-shaped beam and active cathode cooling. The paper describes the current status of the project.

  15. Bone metastasis treatment using magnetic resonance-guided high intensity focused ultrasound

    NARCIS (Netherlands)

    Yeo, Sin Yuin; Elevelt, Aaldert; Donato, Katia; van Rietbergen, Bert; ter Hoeve, Natalie D.; van Diest, Paul J.; Grüll, Holger

    2015-01-01

    Objectives: Bone pain resulting from cancer metastases reduces a patient's quality of life. Magnetic Resonance-guided High Intensity Focused Ultrasound (MR-HIFU) is a promising alternative palliative thermal treatment technique for bone metastases that has been tested in a few clinical studies. Here

  16. Creatine supplementation spares muscle glycogen during high intensity intermittent exercise in rats

    Directory of Open Access Journals (Sweden)

    Costa André

    2010-01-01

    Full Text Available Abstract Background The effects of creatine (CR supplementation on glycogen content are still debatable. Thus, due to the current lack of clarity, we investigated the effects of CR supplementation on muscle glycogen content after high intensity intermittent exercise in rats. Methods First, the animals were submitted to a high intensity intermittent maximal swimming exercise protocol to ensure that CR-supplementation was able to delay fatigue (experiment 1. Then, the CR-mediated glycogen sparing effect was examined using a high intensity intermittent sub-maximal exercise test (fixed number of bouts; six bouts of 30-second duration interspersed by two-minute rest interval (experiment 2. For both experiments, male Wistar rats were given either CR supplementation or placebo (Pl for 5 days. Results As expected, CR-supplemented animals were able to exercise for a significant higher number of bouts than Pl. Experiment 2 revealed a higher gastrocnemius glycogen content for the CR vs. the Pl group (33.59%. Additionally, CR animals presented lower blood lactate concentrations throughout the intermittent exercise bouts compared to Pl. No difference was found between groups in soleus glycogen content. Conclusion The major finding of this study is that CR supplementation was able to spare muscle glycogen during a high intensity intermittent exercise in rats.

  17. High-intensity interval training evokes larger serum BDNF levels compared with intense continuous exercise.

    Science.gov (United States)

    Saucedo Marquez, Cinthia Maria; Vanaudenaerde, Bart; Troosters, Thierry; Wenderoth, Nicole

    2015-12-15

    Exercise can have a positive effect on the brain by activating brain-derived neurotrophic factor (BDNF)-related processes. In healthy humans there appears to be a linear relationship between exercise intensity and the positive short-term effect of acute exercise on BDNF levels (i.e., the highest BDNF levels are reported after high-intensity exercise protocols). Here we performed two experiments to test the effectiveness of two high-intensity exercise protocols, both known to improve cardiovascular health, to determine whether they have a similar efficacy in affecting BDNF levels. Participants performed a continuous exercise (CON) protocol at 70% of maximal work rate and a high-intensity interval-training (HIT) protocol at 90% of maximal work rate for periods of 1 min alternating with 1 min of rest (both protocols lasted 20 min). We observed similar BDNF kinetics in both protocols, with maximal BDNF concentrations being reached toward the end of training (experiment 1). We then showed that both exercise protocols significantly increase BDNF levels compared with a rest condition (CON P = 0.04; HIT P exercise are slightly more effective than continuous high-intensity exercise for elevating serum BDNF. Additionally, 73% of the participants preferred the HIT protocol (P = 0.02). Therefore, we suggest that the HIT protocol might represent an effective and preferred intervention for elevating BDNF levels and potentially promoting brain health.

  18. Windowless microfluidic platform based on capillary burst valves for high intensity x-ray measurements

    DEFF Research Database (Denmark)

    Vig, Asger Laurberg; Haldrup, Kristoffer; Enevoldsen, Nikolaj Brandt;

    2009-01-01

    We propose and describe a microfluidic system for high intensity x-ray measurements. The required open access to a microfluidic channel is provided by an out-of-plane capillary burst valve (CBV). The functionality of the out-of-plane CBV is characterized with respect to the diameter of the window...

  19. High intensity polarization entangled source with a 2D nonlinear photonic crystal

    DEFF Research Database (Denmark)

    Wang, Qin

    2009-01-01

    We gave a proposal on how to use a piece of two-dimension (2D) nonlinear photonic crystal to generate a polarization entangled source. It provides not only has a high stability, but also a high entangled quality and a high intensity. Moreover, our scheme involves only practical experimental...

  20. The Edward Teller Medal Lecture: High Intensity Lasers and the Road to Ignition (lirpp Vol. 13)

    Science.gov (United States)

    Key, M. H.

    2016-10-01

    There has been much progress in the development of high intensity lasers and in the science of laser driven inertially confined fusion such that ignition is now a near term prospect. This lecture reviews the field with particular emphasis on areas of my own involvement.

  1. Work in progress at the North Area High Intensity Facility (NAHIF)

    CERN Document Server

    1979-01-01

    The photo shows the exit of the two MBN-type magnets in tunnel TDC85 (upstream of TCC8), used to 'switch' the primary proton beam either towards target T8 (to the left) or onto target T10 (straight) to produce the H10 or the F12 (high-intensity electron/gamma) beam, respectively.

  2. High Intensity Pressure Noise Transmission in Human Ear: A Three Dimensional Simulation Study

    Science.gov (United States)

    Hawa, Takumi; Gan, Rong; Leckness, Kegan

    2015-03-01

    High intensity pressure noise generated by explosions and jet engines causes auditory damage and hearing loss of the military service personals, which are the most common disabilities in the veterans. Authors have investigated the high intensity pressure noise transmission from the ear canal to middle ear cavity. A fluid-structure interaction with a viscoelastic model for the tympanic membrane (TM) as well as the ossicular chain has been considered in the study. For the high intensity pressure simulation the geometry of the ear was based on a 3D finite element (FE) model of the human ear reported by Gan et al. (Ann Biomed Eng 2004). The model consists of the ear canal, TM, ossicular chain, and the middle ear cavity. The numerical approach includes two steps: 1) FE based finite-volume method simulation to compute pressure distributions in the ear canal and the middle ear cavity using CFX; and 2) FE modeling of TM and middle ear ossicles in response to high intensity sound using multi-physics analysis in ANSYS. The simulations provide the displacement of the TM/ossicular chain and the pressure fields in the ear canal and the middle ear cavity. These results are compared with human temporal bone experimental data obtained in our group. This work was supported by DOD W81XWH-14-1-0228.

  3. Sodium bicarbonate intake improves high-intensity intermittent exercise performance in trained young men

    DEFF Research Database (Denmark)

    Krustrup, Peter; Ermidis, Georgios; Mohr, Magni

    2015-01-01

    Background Sodium bicarbonate intake has been shown to improve exercise tolerance, but the effects on high-intensity intermittent exercise are less clear. Thus, the aim of the present study was to determine the effect of sodium bicarbonate intake on Yo-Yo intermittent recovery level 2 test perfor...

  4. Postexercise cold-water immersion improves intermittent high-intensity exercise performance in normothermia.

    Science.gov (United States)

    McCarthy, Avina; Mulligan, James; Egaña, Mikel

    2016-11-01

    A brief cold water immersion between 2 continuous high-intensity exercise bouts improves the performance of the latter compared with passive recovery in the heat. We investigated if this effect is apparent in normothermic conditions (∼19 °C), employing an intermittent high-intensity exercise designed to reflect the work performed at the high-intensity domain in team sports. Fifteen young active men completed 2 exhaustive cycling protocols (Ex1 and Ex2: 12 min at 85% ventilatory threshold (VT) and then an intermittent exercise alternating 30-s at 40% peak power (Ppeak) and 30 s at 90% Ppeak to exhaustion) separated by 15 min of (i) passive rest, (ii) 5-min cold-water immersion at 8 °C, and (iii) 10-min cold-water immersion at 8 °C. Core temperature, heart rate, rates of perceived exertion, and oxygen uptake kinetics were not different during Ex1 among conditions. Time to failure during the intermittent exercise was significantly (P intermittent high-intensity exercise compared with passive rest in normothermia due, at least in part, to reductions in core temperature, circulatory strain, and effort perception.

  5. Effects of 12 weeks high-intensity & reduced-volume training in elite athletes

    DEFF Research Database (Denmark)

    Kilen, Anders; Larsson, Tanja Hultengren; Jørgensen, Majke;

    2014-01-01

    It was investigated if high-intensity interval training (HIT) at the expense of total training volume improves performance, maximal oxygen uptake and swimming economy. 41 elite swimmers were randomly allocated to a control (CON) or HIT group. For 12 weeks both groups trained ∼12 h per week. HIT c...

  6. Responses of Plasma Atrial Natriuretic Peptide to High Intensity Submaximal Exercise in the Heat,

    Science.gov (United States)

    1987-06-01

    Natriuretic Peptide to LnHigh Intensity Submaximal Exercise in the Heat 0 " William J. Kraemer. Lawrence E. Armstrong, Roger W. Hubbard. :I[_] Louis J...atriopeptins in rat adrenal cells. Cir Res 57: 113-118. f V-0C -- V- - IF -I 7 - % 7 -. 17 Chartier L. Schiffrin EL. Thibault G (1984). Effects of atrial

  7. Electrostatic design and beam transport for a folded tandem electrostatic quadrupole accelerator facility for accelerator-based boron neutron capture therapy

    Energy Technology Data Exchange (ETDEWEB)

    Thatar Vento, V., E-mail: Vladimir.ThatarVento@gmail.com [Gerencia de Investigacion y Aplicaciones, CNEA, Av. Gral. Paz 1499 (1650), San Martin, Buenos Aires (Argentina)] [CONICET, Av. Rivadavia 1917 (1033), Ciudad Autonoma de Buenos Aires (Argentina); Bergueiro, J.; Cartelli, D. [Gerencia de Investigacion y Aplicaciones, CNEA, Av. Gral. Paz 1499 (1650), San Martin, Buenos Aires (Argentina)] [CONICET, Av. Rivadavia 1917 (1033), Ciudad Autonoma de Buenos Aires (Argentina); Valda, A.A. [Gerencia de Investigacion y Aplicaciones, CNEA, Av. Gral. Paz 1499 (1650), San Martin, Buenos Aires (Argentina)] [Escuela de Ciencia y Tecnologia, UNSAM, M. Irigoyen 3100 (1650), San Martin, Buenos Aires (Argentina); Kreiner, A.J. [Gerencia de Investigacion y Aplicaciones, CNEA, Av. Gral. Paz 1499 (1650), San Martin, Buenos Aires (Argentina)] [CONICET, Av. Rivadavia 1917 (1033), Ciudad Autonoma de Buenos Aires (Argentina)] [Escuela de Ciencia y Tecnologia, UNSAM, M. Irigoyen 3100 (1650), San Martin, Buenos Aires (Argentina)

    2011-12-15

    Within the frame of an ongoing project to develop a folded Tandem-Electrostatic-Quadrupole (TESQ) accelerator facility for Accelerator-Based Boron Neutron Capture Therapy (AB-BNCT), we discuss here the electrostatic design of the machine, including the accelerator tubes with electrostatic quadrupoles and the simulations for the transport and acceleration of a high intensity beam.

  8. Acute Effect of High-Intensity Eccentric Exercise on Vascular Endothelial Function in Young Men.

    Science.gov (United States)

    Choi, Youngju; Akazawa, Nobuhiko; Zempo-Miyaki, Asako; Ra, Song-Gyu; Shiraki, Hitoshi; Ajisaka, Ryuichi; Maeda, Seiji

    2016-08-01

    Choi, Y, Akazawa, N, Zempo-Miyaki, A, Ra, S-G, Shiraki, H, Ajisaka, R, and Maeda, S. Acute effect of high-intensity eccentric exercise on vascular endothelial function in young men. J Strength Cond Res 30(8): 2279-2285, 2016-Increased central arterial stiffness is as an independent risk factor for cardiovascular disease. Evidence regarding the effects of high-intensity resistance exercise on vascular endothelial function and central arterial stiffness is conflicting. The purpose of this study was to examine the effects of acute high-intensity eccentric exercise on vascular endothelial function and central arterial stiffness. We evaluated the acute changes in endothelium-dependent flow-mediated dilation (FMD), low-flow-mediated constriction (L-FMC), and arterial stiffness after high-intensity eccentric exercise. Seven healthy, sedentary men (age, 24 ± 1 year) performed maximal eccentric elbow flexor exercise using their nondominant arm. Before and 45 minutes after eccentric exercise, carotid arterial compliance and brachial artery FMD and L-FMC in the nonexercised arm were measured. Carotid arterial compliance was significantly decreased, and β-stiffness index significantly increased after eccentric exercise. Brachial FMD was significantly reduced after eccentric exercise, whereas there was no significant difference in brachial L-FMC before and after eccentric exercise. A positive correlation was detected between change in arterial compliance and change in FMD (r = 0.779; p ≤ 0.05), and a negative correlation was detected between change in β-stiffness index and change in FMD (r = -0.891; p eccentric exercise. In this study, acute high-intensity eccentric exercise increased central arterial stiffness; this increase was accompanied by a decrease in endothelial function caused by reduced endothelium-dependent vasodilation but not by a change in endothelium-dependent vasoconstriction.

  9. Psychophysiological effects of music on acute recovery from high-intensity interval training.

    Science.gov (United States)

    Jones, Leighton; Tiller, Nicholas B; Karageorghis, Costas I

    2017-03-01

    Numerous studies have examined the multifarious effects of music applied during exercise but few have assessed the efficacy of music as an aid to recovery. Music might facilitate physiological recovery via the entrainment of respiratory rhythms with music tempo. High-intensity exercise training is not typically associated with positive affective responses, and thus ways of assuaging negative affect warrant further exploration. This study assessed the psychophysiological effects of music on acute recovery and prevalence of entrainment in between bouts of high-intensity exercise. Thirteen male runners (Mage=20.2±1.9years; BMI=21.7±1.7; V̇O2 max=61.6±6.1mL·kg·min(-1)) completed three exercise sessions comprising 5×5-min bouts of high-intensity intervals interspersed with 3-min periods of passive recovery. During recovery, participants were administered positively-valenced music of a slow-tempo (55-65bpm), fast-tempo (125-135bpm), or a no-music control. A range of measures including affective responses, RPE, cardiorespiratory indices (gas exchange and pulmonary ventilation), and music tempo-respiratory entrainment were recorded during exercise and recovery. Fast-tempo, positively-valenced music resulted in higher Feeling Scale scores throughout recovery periods (p<0.01, ηp(2)=0.38). There were significant differences in HR during initial recovery periods (p<0.05, ηp(2)=0.16), but no other music-moderated differences in cardiorespiratory responses. In conclusion, fast-tempo, positively-valenced music applied during recovery periods engenders a more pleasant experience. However, there is limited evidence that music expedites cardiorespiratory recovery in between bouts of high-intensity exercise. These findings have implications for athletic training strategies and individuals seeking to make high-intensity exercise sessions more pleasant.

  10. Self-shielded electron linear accelerators designed for radiation technologies

    Science.gov (United States)

    Belugin, V. M.; Rozanov, N. E.; Pirozhenko, V. M.

    2009-09-01

    This paper describes self-shielded high-intensity electron linear accelerators designed for radiation technologies. The specific property of the accelerators is that they do not apply an external magnetic field; acceleration and focusing of electron beams are performed by radio-frequency fields in the accelerating structures. The main characteristics of the accelerators are high current and beam power, but also reliable operation and a long service life. To obtain these characteristics, a number of problems have been solved, including a particular optimization of the accelerator components and the application of a variety of specific means. The paper describes features of the electron beam dynamics, accelerating structure, and radio-frequency power supply. Several compact self-shielded accelerators for radiation sterilization and x-ray cargo inspection have been created. The introduced methods made it possible to obtain a high intensity of the electron beam and good performance of the accelerators.

  11. 美国MARS海底观测网络中国节点试验%Test China Node on Monterey Accelerated Research System(MARS)

    Institute of Scientific and Technical Information of China (English)

    彭晓彤; 冯正平; 李德平; 周怀阳; 吴邦春; 吕枫; 吴正伟; 杨灿军; 李培良; 李德俊; 金波

    2011-01-01

    MARS海底观测网络是国际深海海底观测网络组网设备的主要试验场所。2011年4月21日,由接驳盒子系统、海底化学环境监测子系统和海底动力环境监测子系统等海底观测网络组网设备组成的中国节点与美国MARS海底观测网络主节点成功接并,检测和考验了我国深海海底观测网络组网关键设备的主要性能,中国成为第三个在MARS网上进行大规模组网设备测试的国家。到目前为止,中国节点在MARS网上的运行稳定,正源源不断从美国蒙特利湾海底传回各种观测数据,表明我国深海海底观测网络组网关键技术已取得了重要突破,基本达到了实际应用水平。实时、高分辨率和海量的数据特征为开展海洋科学研究提供了宝贵的资料,显示了利用海底观测网络开展海洋科学研究的巨大优势。%Monterey Accelerated Research System(MARS) is a main test bed for the deep-sea observatory instruments in the world.On April 14 th,2011,a China node,which consists of a junction box,a chemical environment system and a dynamical environment system,was installed on MARS successfully by R/V Western Flyer,R/V Point Lobos and ROV Ventana for long-term test at the seafloor of Monterey Bay.China became the third country who tested her deep-sea observatory instruments on MARS on a large scale.Up to date,China node works well on MARS.The instruments of China node are sending data back from the seafloor of Monterey Bay.China node test on MARS shows that Chinese observatory technologies have had great progresses in the recent four years,which can be applied to the construction of the deep-sea observatory in China.Real-time data from China node will benefit marine research and show great advantages of deep-sea observatory.

  12. Ponderomotive Acceleration by Relativistic Waves

    CERN Document Server

    Lau, Calvin; Yeh, Po-Chun; Luk, Onnie; McClenaghan, Joseph; Ebisuzaki, Toshikazu; Tajima, Toshiki

    2014-01-01

    In the extreme high intensity regime of electromagnetic (EM) waves in plasma, the acceleration process is found to be dominated by the ponderomotive acceleration (PA). While the wakefields driven by the ponderomotive force of the relativistic intensity EM waves are important, they may be overtaken by the PA itself in the extreme high intensity regime when the dimensionless vector potential $a_0$ of the EM waves far exceeds unity. The energy gain by this regime (in 1D) is shown to be (approximately) proportional to $a_0^2$. Before reaching this extreme regime, the coexistence of the PA and the wakefield acceleration (WA) is observed where the wave structures driven by the wakefields show the phenomenon of multiple and folded wave-breakings. Investigated are various signatures of the acceleration processes such as the dependence on the mass ratio for the energy gain as well as the energy spectral features. The relevance to high energy cosmic ray acceleration and to the relativistic laser acceleration is conside...

  13. Research on ZrO2 Thermal Barrier Coatings Modified by High-Intensity Pulsed Ion Beam

    Institute of Scientific and Technical Information of China (English)

    WV Di; LIU Chen; ZHU Xiao-Peng; LEI Ming-Kai

    2008-01-01

    @@ We report a modification method for ZrO2 thermal barrier coatings (TBCs) by high-intensity pulsed ion beam (HIPIB) irradiation. Based on the temporal and spatial distribution models of the ion beam density detected by Faraday cup in the chamber and the ions accelerating voltage, the energy deposition of the beam ions in ZrO2 is calculated by Monte Carlo method. Taking this time-dependent nonlinear deposited energy as the source term of two-dimensional thermal conduction equation, we obtain the temporal and spatial ablation process of ZrO2 thermal barrier coatings during a pulse time. The top-layer TBC material in thickness of about 0.2μm is ablated by vaporization and the coating in thickness of 1 μm is melted after one shot at the ion current density of 200 A/cm2. This calculation is in reasonable agreement with those measured by HIPIB irradiation experiments.The melted top coat becoming a dense modification layer due to HIPIB irradiation seals the gaps among ZrO2crystal clusters, and hence barrels the direct tunnel of oxygen.

  14. The Effect of Eight Weeks of High Intensive Special Preparation on Selected Biomechanical and Anthropometrical Parameters in Young Elite Wrestlers

    Directory of Open Access Journals (Sweden)

    Hamidreza Naserpour

    2015-09-01

    Full Text Available Objective: The aim of this study was to investigate the effect of eight weeks of high intensive exercise on selected biomechanical and anthropometrical variables in elite wrestlers. Methods: Sixteen young wrestlers (age 19.1±1 years and weight 74.9±17.3 kg attending the national Greco-Roman camps participated in this study. Biomechanical and anthropometrical variables included weight, body fat percentage, body mass index, balance, general body speed and acceleration, active range of motion of the joints, upper and lower extremities power and hand grip strength. These variables were measured before and after 8 weeks (67 sessions of special exercise training. The normality of data was checked by Kolmogorov- Smirnov normality measure and data were analyzed with Paired- samples t-test to compare variables before and after training program, with a significance level of (P≤0.05. Results: Results showed that there were significant differences between weight, body fat percentage, body mass index, semi-dynamic balance in the medial and anterior-medial directions, upper extremities power, the range of lateral flexion to the right of the neck and hip flexion of pre and post-test. Conclusion: Based on the results, it seems that applied training program had main effect on biomechanical and anthropometrical variables such as weight, body fat percentage, body mass index, power, balance and active range of motion of elite wrestlers that will increase the qualitative athletic performance

  15. The activation of tissue factor by high intensity focused ultrasound—a pathway to acoustic-biochemical hemostasis

    Science.gov (United States)

    Yang, Xinmai; Barber, Frank E.; Morrissey, James H.; Church, Charles C.

    2006-05-01

    High intensity focused ultrasound (HIFU) is believed to have great potential for inducing hemostasis in severely bleeding trauma victims. The addition of HIFU-activated biomolecular substances to the blood during treatment could significantly reduce the time required to achieve hemostasis, but such substances must remain inactive everywhere except at the site of injury. The integral-membrane protein, tissue factor (TF), is by far the most potent known trigger for the blood clotting cascade. We propose to employ liposomes with the extracellular domain of TF facing the lumen ("encrypted TF") to allow the TF molecules to be introduced into the blood stream without causing systemic activation of coagulation. HIFU sonication at the site of injury will be used to break up the liposomes and thereby expose TF to the plasma, thus combining the hemostatic potential of HIFU along with an increase in the rate of clot formation triggered by TF. In our initial studies we have produced a range of concentrations of liposomes containing encrypted TF in a buffer solution and exposed them to ultrasound at a number of different intensity levels and duty cycles. Clotting assays were performed to determine the level of the desired effect of the ultrasound. The results suggest that HIFU can be effective in exposing active TF from the encrypted liposomes to accelerate blood clotting at the site of exposure.

  16. Effects of High-Intensity Blood Flow Restriction Exercise on Muscle Fatigue

    Directory of Open Access Journals (Sweden)

    Neto Gabriel R.

    2014-07-01

    Full Text Available Strength training combined with blood flow restriction (BFR have been used to improve the levels of muscle adaptation. The aim of this paper was to investigate the acute effect of high intensity squats with and without blood flow restriction on muscular fatigue levels. Twelve athletes (aged 25.95 ± 0.84 years were randomized into two groups: without Blood Flow Restriction (NFR, n = 6 and With Blood Flow Restriction (WFR, n = 6 that performed a series of free weight squats with 80% 1-RM until concentric failure. The strength of the quadriceps extensors was assessed in a maximum voluntary isometric contraction integrated to signals from the surface electromyogram. The average frequency showed significant reductions in the WFR group for the vastus lateralis and vastus medialis muscles, and intergroup only for the vastus medialis. In conclusion, a set of squats at high intensity with BFR could compromise muscle strength immediately after exercise, however, differences were not significant between groups.

  17. Moderate-to-high intensity aerobic exercise in patients with mild to moderate Alzheimer's disease

    DEFF Research Database (Denmark)

    Frederiksen, Kristian S; Sobol, Nanna; Beyer, Nina;

    2014-01-01

    OBJECTIVES: Physical exercise may modulate neuropathology and symptoms of Alzheimer's disease (AD). This pilot study assessed the feasibility of conducting a study of moderate-to-high intensity aerobic exercise in home-dwelling patients with mild AD. METHODS: An uncontrolled preintervention......-postintervention test design with a single group receiving the same intervention. A total of eight patients with mild to moderate AD from the Copenhagen Memory clinic were included in the study. The intervention lasted for 14 weeks and consisted of supervised, 1-h sessions of aerobic exercise three times per week (50......-to-high intensity aerobic exercise in community-dwelling patients with mild AD. Our findings indicate that aspects such as a longer adaptation period, information about injury prevention, and need for involvement and support from caregivers should be addressed when planning an exercise intervention in an AD...

  18. Recovery of a soil under different vegetation one year after a high intensity wildfire

    Directory of Open Access Journals (Sweden)

    A. Martín

    2013-05-01

    Full Text Available Studies on soil recovery in fragile ecosystems following high intensity wildfires are scarce. The aim of the present investigation is to evaluate the impact of a high intensity wildfire in an ecosystem under different vegetation (shrubland and pinewood located at Vilardevós (Galicia, NW Spain and highly susceptible to suffer soil erosion due to the steep relief and high erositivity of the rainfall. Soil samples were collected from the A horizon (0-5 cm 1 year after the fire and soil quality was evaluated by analysis of several physical, chemical and biochemical properties measured in the fraction chemical properties > physical properties. The data also showed that the fire impact was different depending on the soil vegetation considered (shrubland and pinewood. Moreover, the data confirmed the slow soil recovery in this fragile ecosystem and, therefore, the need of adopting post-fire stabilisation and rehabilitation treatments in order to minimize the post-fire erosion and soil degradation.

  19. High performance computation on beam dynamics problems in high intensity compact cyclotrons

    Institute of Scientific and Technical Information of China (English)

    ADELMANN; Andreas

    2011-01-01

    This paper presents the research progress in the beam dynamics problems for future high intensity compact cyclotrons by utilizing the state-of-the-art high performance computation technology. A "Start-to-Stop" model, which includes both the interaction of the internal particles of a single bunch and the mutual interaction of neighboring multiple bunches in the radial direction, is established for compact cyclotrons with multi-turn extraction. This model is then implemented in OPAL-CYCL, which is a 3D object-oriented parallel code for large scale particle simulations in cyclotrons. In addition, to meet the running requirement of parallel computation, we have constructed a small scale HPC cluster system and tested its performance. Finally, the high intensity beam dynamics problems in the 100 MeV compact cyclotron, which is being constructed at CIAE, are studied using this code and some conclusions are drawn.

  20. Transverse Beam Halo Measurements at High Intensity Neutrino Source (HINS) using Vibrating Wire Monitor

    Energy Technology Data Exchange (ETDEWEB)

    Chung, M.; Hanna, B.; Scarpine, V.; Shiltsev, V.; Steimel, J.; Artinian, S.; Arutunian, S.

    2015-02-26

    The measurement and control of beam halos will be critical for the applications of future high-intensity hadron linacs. In particular, beam profile monitors require a very high dynamic range when used for the transverse beam halo measurements. In this study, the Vibrating Wire Monitor (VWM) with aperture 60 mm was installed at the High Intensity Neutrino Source (HINS) front-end to measure the transverse beam halo. A vibrating wire is excited at its resonance frequency with the help of a magnetic feedback loop, and the vibrating and sensitive wires are connected through a balanced arm. The sensitive wire is moved into the beam halo region by a stepper motor controlled translational stage. We study the feasibility of the vibrating wire for the transverse beam halo measurements in the low-energy front-end of the proton linac.

  1. Beam Dynamics Observations of the 2015 High Intensity Scrubbing Runs at the Cern Sps

    CERN Document Server

    Bartosik, Hannes; Li, Kevin; Mether, Lotta; Romano, Annalisa; Rumolo, Giovanni; Schenk, Michael

    2016-01-01

    Beam quality degradation caused by e-cloud effects has been identified as one of the main performance limitations for high intensity LHC beams with 25 ns bunch spacing in the SPS. In view of the beam parameters targeted with the LHC injectors upgrade (LIU) project, about two weeks of SPS machine time in 2015 were devoted to dedicated scrubbing runs with high intensity LHC 25 ns and dedicated 'doublet' beams in order to study the achievable reduction of e-cloud effects and quantify the consequent beam performance improvements. This paper describes the main observations concerning the coherent instabilities and beam dynamics limitations encountered as well as a detailed characterisation of the performance reach with the highest beam intensity presently available from the pre-injectors.

  2. High Intensity Laser Power Beaming Architecture for Space and Terrestrial Missions

    Science.gov (United States)

    Nayfeh, Taysir; Fast, Brian; Raible, Daniel; Dinca, Dragos; Tollis, Nick; Jalics, Andrew

    2011-01-01

    High Intensity Laser Power Beaming (HILPB) has been developed as a technique to achieve Wireless Power Transmission (WPT) for both space and terrestrial applications. In this paper, the system architecture and hardware results for a terrestrial application of HILPB are presented. These results demonstrate continuous conversion of high intensity optical energy at near-IR wavelengths directly to electrical energy at output power levels as high as 6.24 W from the single cell 0.8 cm2 aperture receiver. These results are scalable, and may be realized by implementing receiver arraying and utilizing higher power source lasers. This type of system would enable long range optical refueling of electric platforms, such as MUAV s, airships, robotic exploration missions and provide power to spacecraft platforms which may utilize it to drive electric means of propulsion.

  3. Short-term effects of implemented high intensity shoulder elevation during computer work

    DEFF Research Database (Denmark)

    Larsen, Mette K.; Samani, Afshin; Madeleine, Pascal

    2009-01-01

    elevation. RPE was reported, productivity (drawings per min) measured, and bipolar surface electromyography (EMG) recorded from the dominant upper trapezius during pauses and sessions of computer work. Repeated measure ANOVA with Bonferroni corrected post-hoc tests was applied for the statistical analyses......BACKGROUND: Work-site strength training sessions are shown effective to prevent and reduce neck-shoulder pain in computer workers, but difficult to integrate in normal working routines. A solution for avoiding neck-shoulder pain during computer work may be to implement high intensity voluntary...... contractions during the computer work. However, it is unknown how this may influence productivity, rate of perceived exertion (RPE) as well as activity and rest of neck-shoulder muscles during computer work. The aim of this study was to investigate short-term effects of a high intensity contraction...

  4. Effect of moderate- and high-intensity acute exercise on appetite in obese individuals

    DEFF Research Database (Denmark)

    Martins, Catia; Stensvold, Dorthe; Finlayson, Graham

    2015-01-01

    cycling (MICC) or short-duration HIIC (S-HIIC) (125 kcal) and a resting control condition on the appetite hormone responses, subjective feelings of appetite, energy intake (EI), and food reward in overweight/obese individuals. METHODS: This study is a randomized crossover study on 12 overweight/obese......, hunger or fullness ratings, EI, or food reward. CONCLUSIONS: Our findings suggest that, in overweight/obese individuals, isocaloric bouts of moderate- or high-intensity exercise lead to a similar appetite response. This strengthens previous findings in normal-weight individuals that acute exercise, even......PURPOSE: The effect of acute exercise, and exercise intensity, on appetite control in obese individuals requires further study. The aim of this study was to compare the effects of acute isocaloric bouts (250 kcal) of high-intensity intermittent cycling (HIIC) and moderate-intensity continuous...

  5. Laser-enhanced cavitation during high intensity focused ultrasound: An in vivo study

    OpenAIRE

    Cui, Huizhong; Zhang, Ti; Yang, Xinmai

    2013-01-01

    Laser-enhanced cavitation during high intensity focused ultrasound (HIFU) was studied in vivo using a small animal model. Laser light was employed to illuminate the sample concurrently with HIFU radiation. The resulting cavitation was detected with a passive cavitation detector. The in vivo measurements were made under different combinations of HIFU treatment depths, laser wavelengths, and HIFU durations. The results demonstrated that concurrent light illumination during HIFU has the potentia...

  6. Repeated high-intensity running and sprinting in elite women’s soccer competition

    OpenAIRE

    Gabbett, Tim J; Wiig, Håvard; Spencer, Matt

    2013-01-01

    Background: To the authors’ knowledge, no study has investigated the concurrent repeated, high-intensity (RHIA) and repeated-sprint activity (RSA) of intermittent team-sport competition. Purpose: In this study, they report on the RSA of elite women’s football competition. In addition, they describe the nature of RHIA (eg, striding and sprinting activities) that involve a high energy cost and are associated with short (ie, ≤20 s) recovery periods. Methods: Thirteen elite women soccer players u...

  7. MR-guided high-intensity focused ultrasound treatment of uterine fibroids

    OpenAIRE

    2016-01-01

    Antonia Wiggermann,1 Michael Beldoch,1 Friederike Hoellen,2 Peter Hunold1 1Clinic for Radiology and Nuclear Medicine, 2Department of Obstetrics and Gynecology, University Hospital Schleswig-Holstein, Lübeck, Germany Abstract: Uterine fibroids are benign, encapsulated uterine tumors, representing the most common reason for hysterectomy in premenopausal women. High-intensity focused ultrasound (HIFU; also known as focused ultrasound surgery) is a noninvasive technique leading to tissu...

  8. High-intensity focused ultrasound to treat primary hyperparathyroidism: a feasibility study in four patients

    DEFF Research Database (Denmark)

    Kovatcheva, Roussanka D; Vlahov, Jordan D; Shinkov, Alexander D;

    2010-01-01

    Many patients with primary hyperparathyroidism either decline or are not candidates for surgical parathyroidectomy. There are drawbacks to medical therapy as well as percutaneous ethanol injection as alternative therapies for primary hyperparathyroidism. Therefore, in this pilot study, our aim...... was to test the feasibility, safety, and efficacy of a newly developed noninvasive high-intensity focused ultrasound (HIFU) technique for the nonsurgical management of primary hyperparathyroidism....

  9. Personalized Metabolomics for Predicting Glucose Tolerance Changes in Sedentary Women After High-Intensity Interval Training

    OpenAIRE

    Kuehnbaum, Naomi L.; Gillen, Jenna B.; Gibala, Martin J.; Britz-McKibbin, Philip

    2014-01-01

    High-intensity interval training (HIIT) offers a practical approach for enhancing cardiorespiratory fitness, however its role in improving glucose regulation among sedentary yet normoglycemic women remains unclear. Herein, multi-segment injection capillary electrophoresis-mass spectrometry is used as a high-throughput platform in metabolomics to assess dynamic responses of overweight/obese women (BMI > 25, n = 11) to standardized oral glucose tolerance tests (OGTTs) performed before and after...

  10. A Highly intense DC muon source, MuSIC and muon CLFV search

    Science.gov (United States)

    Hino, Y.; Kuno, Y.; Sato, A.; Sakamoto, H.; Matsumoto, Y.; Tran, N. H.; Hashim, I. H.; Fukuda, M.; Hayashida, Y.; Ogitsu, T.; Yamamoto, A.; Yoshida, M.

    2014-08-01

    MuSIC is a new muon facility, which provides the world's highest intense muon beam with continuous time structure at Research Center of Nuclear Physics (RCNP), Osaka University. It's intensity is designed to be 108 muons per second with only 0.4 kW proton beam. Such a high intense muon beam is very important for searches of rare decay processes, for example search for the muon to electron conversion.

  11. A Rectourethral Fistula due to Transrectal High-Intensity Focused Ultrasound Treatment: Diagnosis and Management

    OpenAIRE

    2012-01-01

    Colovesical fistula (CVF) is an abnormal connection between the enteric and the urinary systems. The rectourethral fistula (RUF) is a possible but extremely rare complication of treatment of prostate cancer with “transrectal High-Intensity Focused Ultrasound (HIFU) treatment.” We present a case of CVF due to HIFU treatment of recurrent prostate cancer. The case was assessed with cystography completed with a pelvic CT scan—with MPR, MIP, and VR reconstruction—before emptying the bladder. Since...

  12. Report from the NSLS workshop: Sources and applications of high intensity uv-vuv light

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, E.D.; Hastings, J.B. [eds.

    1990-12-31

    A workshop was held to evaluate sources and applications of high intensity, ultra violet (UV) radiation for biological, chemical, and materials sciences. The proposed sources are a UV free electron laser (FEL) driven by a high brightness linac and undulators in long, straight sections of a specially designed low energy (400 MeV) storage ring. These two distinct types of sources will provide a broad range of scientific opportunities that were discussed in detail during the workshop.

  13. Report from the NSLS workshop: Sources and applications of high intensity uv-vuv light

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, E.D.; Hastings, J.B. (eds.)

    1990-01-01

    A workshop was held to evaluate sources and applications of high intensity, ultra violet (UV) radiation for biological, chemical, and materials sciences. The proposed sources are a UV free electron laser (FEL) driven by a high brightness linac and undulators in long, straight sections of a specially designed low energy (400 MeV) storage ring. These two distinct types of sources will provide a broad range of scientific opportunities that were discussed in detail during the workshop.

  14. Circulating adiponectin concentration and body composition are altered in response to high-intensity interval training.

    Science.gov (United States)

    Shing, Cecilia M; Webb, Jessica J; Driller, Matthew W; Williams, Andrew D; Fell, James W

    2013-08-01

    Adiponectin influences metabolic adaptations that would prove beneficial to endurance athletes, and yet to date there is little known about the response of adiponectin concentrations to exercise, and, in particular, the response of this hormone to training in an athlete population. This study aimed to determine the response of plasma adiponectin concentrations to acute exercise after 2 different training programs and to determine the influence of the training on body composition. Seven state-level representative rowers (age: 19 ± 1.2 years [mean ± SD], height: 1.77 ± 0.10 m, body mass: 74.0 ± 10.7 kg, VO2peak 62.1 ± 7.0 ml·kg·min) participated in the double-blind, randomized crossover investigation. Rowers performed an incremental graded exercise test before and after completing 4 weeks of high-intensity interval ergometer training and 4 weeks of traditional ergometer rowing training. Rowers' body composition was assessed at baseline and after each training program. Significant increases in plasma adiponectin concentration occurred in response to maximal exercise after completion of the high-intensity interval training (p = 0.016) but not after traditional ergometer rowing training (p = 0.69). The high-intensity interval training also resulted in significant increases in mean 4-minute power output (p = 0.002) and VO2peak (p = 0.05), and a decrease in body fat percentage (p = 0.022). Mean 4-minute power output, VO2peak, and body fat percentage were not significantly different after 4 weeks of traditional ergometer rowing training (p > 0.05). Four weeks of high-intensity interval training is associated with an increase in adiponectin concentration in response to maximal exercise and a reduction in body fat percentage. The potential for changes in adiponectin concentration to reflect positive training adaptations and athlete performance level should be further explored.

  15. High-intensity cycle interval training improves cycling and running performance in triathletes.

    Science.gov (United States)

    Etxebarria, Naroa; Anson, Judith M; Pyne, David B; Ferguson, Richard A

    2014-01-01

    Effective cycle training for triathlon is a challenge for coaches. We compared the effects of two variants of cycle high-intensity interval training (HIT) on triathlon-specific cycling and running. Fourteen moderately-trained male triathletes ([Formula: see text]O2peak 58.7 ± 8.1 mL kg(-1) min(-1); mean ± SD) completed on separate occasions a maximal incremental test ([Formula: see text]O2peak and maximal aerobic power), 16 × 20 s cycle sprints and a 1-h triathlon-specific cycle followed immediately by a 5 km run time trial. Participants were then pair-matched and assigned randomly to either a long high-intensity interval training (LONG) (6-8 × 5 min efforts) or short high-intensity interval training (SHORT) (9-11 × 10, 20 and 40 s efforts) HIT cycle training intervention. Six training sessions were completed over 3 weeks before participants repeated the baseline testing. Both groups had an ∼7% increase in [Formula: see text]O2peak (SHORT 7.3%, ±4.6%; mean, ±90% confidence limits; LONG 7.5%, ±1.7%). There was a moderate improvement in mean power for both the SHORT (10.3%, ±4.4%) and LONG (10.7%, ±6.8%) groups during the last eight 20-s sprints. There was a small to moderate decrease in heart rate, blood lactate and perceived exertion in both groups during the 1-h triathlon-specific cycling but only the LONG group had a substantial decrease in the subsequent 5-km run time (64, ±59 s). Moderately-trained triathletes should use both short and long high-intensity intervals to improve cycling physiology and performance. Longer 5-min intervals on the bike are more likely to benefit 5 km running performance.

  16. High-Intensity Intermittent Swimming Improves Cardiovascular Health Status for Women with Mild Hypertension

    Directory of Open Access Journals (Sweden)

    Magni Mohr

    2014-01-01

    Full Text Available To test the hypothesis that high-intensity swim training improves cardiovascular health status in sedentary premenopausal women with mild hypertension, sixty-two women were randomized into high-intensity (n=21; HIT, moderate-intensity (n=21; MOD, and control groups (n=20; CON. HIT performed 6–10 × 30 s all-out swimming interspersed by 2 min recovery and MOD swam continuously for 1 h at moderate intensity for a 15-week period completing in total 44±1 and 43±1 sessions, respectively. In CON, all measured variables were similar before and after the intervention period. Systolic BP decreased (P<0.05 by 6±1 and 4±1 mmHg in HIT and MOD; respectively. Resting heart rate declined (P<0.05 by 5±1 bpm both in HIT and MOD, fat mass decreased (P<0.05 by 1.1±0.2 and 2.2±0.3 kg, respectively, while the blood lipid profile was unaltered. In HIT and MOD, performance improved (P<0.05 for a maximal 10 min swim (13±3% and 22±3%, interval swimming (23±3% and 8±3%, and Yo-Yo IE1 running performance (58±5% and 45±4%. In conclusion, high-intensity intermittent swimming is an effective training strategy to improve cardiovascular health and physical performance in sedentary women with mild hypertension. Adaptations are similar with high- and moderate-intensity training, despite markedly less total time spent and distance covered in the high-intensity group.

  17. Lymphocyte Redox Imbalance and Reduced Proliferation after a Single Session of High Intensity Interval Exercise

    OpenAIRE

    Tossige-Gomes, Rosalina; Costa, Karine Beatriz; Ottone, Vinícius de Oliveira; Magalhães, Flávio de Castro; Amorim, Fabiano Trigueiro; Rocha-Vieira, Etel

    2016-01-01

    This study investigated whether an acute session of high-intensity interval training (HIIT) is sufficient to alter lymphocyte function and redox status. Sixteen young healthy men underwent a HIIT session on a cycloergometer, consisting of eight bouts of 1 min at 90–100% of peak power, with 75 seconds of active recovery at 30 W between bouts. Venous blood was collected before, immediately after, and 30 minutes after the HIIT session. In response to Staphylococcus aureus superantigen B (SEB) st...

  18. A Highly intense DC muon source, MuSIC and muon CLFV search

    Energy Technology Data Exchange (ETDEWEB)

    Hino, Y.; Kuno, Y.; Sato, A. [Department of Physics, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043 (Japan); Sakamoto, H. [Department of Physics, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043 (Japan); Research Center of Nuclear Physics, 10-1 Mihogaoka, Ibaraki, Osaka 567-0047 (Japan); Matsumoto, Y.; Tran, N.H.; Hashim, I.H. [Department of Physics, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043 (Japan); Fukuda, M.; Hayashida, Y. [Research Center of Nuclear Physics, 10-1 Mihogaoka, Ibaraki, Osaka 567-0047 (Japan); Ogitsu, T.; Yamamoto, A.; Yoshida, M. [High Energy Accelerator Research Organization, 1-1 Oho, Tsukuba, Ibaraki 305-0801 (Japan)

    2014-08-15

    MuSIC is a new muon facility, which provides the world's highest intense muon beam with continuous time structure at Research Center of Nuclear Physics (RCNP), Osaka University. It's intensity is designed to be 10{sup 8} muons per second with only 0.4 kW proton beam. Such a high intense muon beam is very important for searches of rare decay processes, for example search for the muon to electron conversion.

  19. Generation of heavy ion beams using high-intensity short pulse lasers

    Science.gov (United States)

    Petrov, George; McGuffey, Chris; Thomas, Alec; Krushelnick, Karl; Beg, Farhat

    2016-10-01

    A theoretical study of ion acceleration from high-Z material irradiated by intense sub-picosecond lasers is presented. The underlying physics of beam formation and acceleration is similar for light and heavy ions, however, nuances of the acceleration process make the heavy ions more challenging. At least four technical hurdles have been identified: low charge-to-mass ratio, limited number of ions amenable to acceleration, delayed acceleration and poor energy coupling due to high reflectivity of the plasma. Using two dimensional particle-in-cell (PIC) simulations, we observed transitions from Radiation Pressure Acceleration (RPA) to the Breakout Afterburner regime (BoA) and to Target Normal Sheath Acceleration (TNSA) akin to light ions. The numerical simulations predict gold ions beams with high directionality (high fluxes (>1011 ions/sr) and energy (>10 MeV/nucleon) from laser systems delivering >20 J of energy on target.

  20. Benefits of High-Intensity Intensive Care Unit Physician Staffing under the Affordable Care Act

    Directory of Open Access Journals (Sweden)

    Sachin Logani

    2011-01-01

    Full Text Available The Affordable Care Act signed into law by President Obama, with its value-based purchasing program, is designed to link payment to quality processes and outcomes. Treatment of critically ill patients represents nearly 1% of the gross domestic product and 25% of a typical hospital budget. Data suggest that high-intensity staffing patterns in the intensive care unit (ICU are associated with cost savings and improved outcomes. We evaluate the literature investigating the cost-effectiveness and clinical outcomes of high-intensity ICU physician staffing as recommended by The Leapfrog Group (a consortium of companies that purchase health care for their employees and identify ways to overcome barriers to nationwide implementation of these standards. Hospitals that have implemented the Leapfrog initiative have demonstrated reductions in mortality and length of stay and increased cost savings. High-intensity staffing models appear to be an immediate cost-effective way for hospitals to meet the challenges of health care reform.

  1. Influence of repeated bouts of eccentric exercise on high-intensity aerobic performance.

    Science.gov (United States)

    Higino, Wonder Passoni; Aparecido de Souza, Renato; Cavalcanti, Fabio de Sousa; Cardoso, Anderlei Dos Santos; Vasconcelos, Murilo Victor; Fernandes da Silva, Fabiano; Leme, José Alexandre C A

    2016-08-01

    [Purpose] It is believed that eccentric high-intensity exercise can decrease performance in subsequent exercise. However, with repetition, the deleterious effects can be minimized. Thus, this study evaluated the influence of repeated bouts of eccentric exercise on subsequent high-intensity aerobic performance. [Subjects and Methods] Seven healthy and sedentary male volunteers were recruited. a) Visit 1: determination of maximum oxygen uptake (VO2max) and speed associated with maximum oxygen uptake (vVO2max) in incremental treadmill testing; b) Visit 2: run to exhaustion at vVO2max (Tlim control); c) Visit 3: 10 sets of 10 depth jumps, followed by a run to exhaustion at vVO2max (Tlim 1); d) Visit 4: after 6 weeks without any physical training, the volunteers carried out the same procedures as on the third visit (Tlim 2). Data were analyzed using one-way analysis of variance (ANOVA) with the post-hoc Tukey test. [Results] Significant differences were found between Tlim control and Tlim 1 (283.4 ± 47.7 s vs. 125.2 ± 64.1 s, respectively), these were not different from Tlim 2. [Conclusion] Eccentric exercise showed deleterious effects on subsequent high-intensity aerobic performance. These effects were minimized after the exercise protocol was repeated 6 weeks after the first event.

  2. High intensity aerobic interval training improves peak oxygen consumption in patients with metabolic syndrome: CAT

    Directory of Open Access Journals (Sweden)

    Alexis Espinoza Salinas

    2014-06-01

    Full Text Available Introduction A number of cardiovascular risk factors characterizes the metabolic syndrome: insulin resistance (IR, low HDL cholesterol and high triglycerides. The aforementioned risk factors lead to elevated levels of abdominal adipose tissue, resulting in oxygen consumption deficiency. Purpose To verify the validity and applicability of using high intensity interval training (HIIT in subjects with metabolic syndrome and to answer the following question: Can HIIT improve peak oxygen consumption? Method The systematic review "Effects of aerobic interval training on exercise capacity and metabolic risk factors in individuals with cardiometabolic disorders" was analyzed. Results Data suggests high intensity aerobic interval training increases peak oxygen consumption by a standardized mean difference of 3.60 mL/kg-1/min-1 (95% confidence interval, 0.28-4.91. Conclusion In spite of the methodological shortcomings of the primary studies included in the systematic review, we reasonably conclude that implementation of high intensity aerobic interval training in subjects with metabolic syndrome, leads to increases in peak oxygen consumption.

  3. Hot electron generation and energy coupling in planar experiments with shock ignition high intensity lasers

    Science.gov (United States)

    Wei, M. S.; Krauland, C.; Alexander, N.; Zhang, S.; Peebles, J.; Beg, F. N.; Theobald, W.; Borwick, E.; Ren, C.; Yan, R.; Haberberger, D.; Betti, R.; Campbell, E. M.

    2016-10-01

    Hot electrons produced in nonlinear laser plasma interactions are critical issues for shock ignition (SI) laser fusion. We conducted planar target experiments to characterize hot electron and energy coupling using the high energy OMEGA EP laser system at SI high intensities. Targets were multilayered foils consisting of an ablator (either plastic or lithium) and a Cu layer to facilitate hot electron detection via fluorescence and bremsstrahlung measurements. The target was first irradiated by multi-kJ, low-intensity UV beams to produce a SI-relevant mm-scale hot ( 1 keV) preformed plasma. The main interaction pulse, either a kJ 1-ns UV pulse with intensity 1.6x1016 Wcm-2 or a kJ 0.1-ns IR pulse with intensity up to 2x1017 Wcm-2was injected at varied timing delays. The high intensity IR beam was found to strongly interact with underdense plasmas breaking into many filaments near the quarter critical density region followed by propagation of those filaments to critical density, producing hot electrons with Thot 70 keV in a well-contained beam. While the high intensity UV beam showed poor energy coupling. Details of the experiments and the complementary PIC modeling results will be presented. Work supported by U.S. DOE under contracts DE-NA0002730 (NLUF) and DE-SC0014666 (HEDLP).

  4. The effect of an intermittent, high-intensity warm-up on supramaximal kayak ergometer performance.

    Science.gov (United States)

    Bishop, David; Bonetti, Darrel; Spencer, Matthew

    2003-01-01

    It has previously been shown that the metabolic acidaemia induced by a continuous warm-up at the 'lactate threshold' is associated with a reduced accumulated oxygen deficit and decreased supramaximal performance. The aim of this study was to determine if an intermittent, high-intensity warm-up could increase oxygen uptake (VO2) without reducing the accumulated oxygen deficit, and thus improve supramaximal performance. Seven male 500 m kayak paddlers, who had represented their state, volunteered for this study. Each performed a graded exercise test to determine VO2max and threshold parameters. On subsequent days and in a random, counterbalanced order, the participants then performed a continuous or intermittent, high-intensity warm-up followed by a 2 min, all-out kayak ergometer test. The continuous warm-up consisted of 15 min of exercise at approximately 65% VO2max. The intermittent, high-intensity warm-up was similar, except that the last 5 min was replaced with five 10 s sprints at 200% VO2max, separated by 50 s of recovery at approximately 55% VO2max. Significantly greater (P kayak ergometer performance is significantly better after an intermittent rather than a continuous warm-up.

  5. Joint Cooling does not Hinder Athletic Performance during High-intensity Intermittent Exercise.

    Science.gov (United States)

    Kim, H; Lee, D; Choi, H-M; Park, J

    2016-07-01

    We examined the effects of ankle and knee joint cooling on 20-m sprint times and maximal vertical jump heights during high-intensity intermittent exercise. 21 healthy collegiate male basketball (n=14) and handball players (n=7) underwent 3 experimental sessions. Each session consisted of four 15-min quarters of high-intensity intermittent exercises including various intensities of 20-m shuttle running and jumping. A 20-min bilateral joint cooling (ankle, knee, or control-no cooling: in a counterbalanced order) was applied before quarters 1 and 3. After joint cooling, no warm-up activity other than the exercise protocol was given. The 20-m sprint times and maximal vertical jump heights in each experimental session were recorded at baseline (prior to quarter-1) and during each quarter. To test joint cooling effects over time, we performed 3×5 mixed model ANOVAs. Neither ankle nor knee joint cooling changed 20-m sprint times (F8,280=1.45; p=0.18) or maximal vertical jump heights (F8,280=0.76; p=0.64). However, a trend was observed in which joint cooling immediately decreased (quarters 1 and 3) but active warm-up for approximately 20 min improved 20-min sprint times (quarters 2 and 4). Our study suggests that athletic performance such as sprinting and jumping are not altered by joint cooling applied prior to or during high-intensity intermittent exercise.

  6. Changes in technique and efficiency after high-intensity exercise in cross-country skiers.

    Science.gov (United States)

    Åsan Grasaas, Christina; Ettema, Gertjan; Hegge, Ann Magdalen; Skovereng, Knut; Sandbakk, Øyvind

    2014-01-01

    This study investigated changes in technique and efficiency after high-intensity exercise to exhaustion in elite cross-country skiers. Twelve elite male skiers completed 4 min submaximal exercise before and after a high-intensity incremental test to exhaustion with the G3 skating technique on a 5% inclined roller-ski treadmill. Kinematics and kinetics were monitored by instrumented roller skis, work rate was calculated as power against roller friction and gravity, aerobic metabolic cost was determined from gas exchange, and blood lactate values indicated the anaerobic contribution. Gross efficiency was the work rate divided by aerobic metabolic rate. A recovery period of 10 min between the incremental test and the posttest was included to allow the metabolic values to return to baseline. Changes in neuromuscular fatigue in upper and lower limbs before and after the incremental test were indicated by peak power in concentric bench press and squat-jump height. From pretest to posttest, cycle length decreased and cycle rate increased by approximately 5% (P ski forces did not change significantly. Oxygen uptake increased by 4%, and gross efficiency decreased from 15.5% ± 0.7% to 15.2% ± 0.5% from pretest to posttest (both P cross-country skiers demonstrated a less efficient technique and shorter cycle length during submaximal roller-ski skating after high-intensity exercise. However, there were no changes in ski forces or peak power in the upper and lower limbs that could explain these differences.

  7. Repeated High Intensity Bouts with Long Recovery: Are Bicarbonate or Carbohydrate Supplements an Option?

    Directory of Open Access Journals (Sweden)

    Thomas Stöggl

    2014-01-01

    Full Text Available The effects of varying recovery modes and the influence of preexercise sodium bicarbonate and carbohydrate ingestion on repeated high intensity performance, acid-base response, and recovery were analyzed in 12 well-trained males. They completed three repeated high intensity running bouts to exhaustion with intervening recovery periods of 25 min under the following conditions: sodium bicarbonate, active recovery (BIC; carbohydrate ingestion, active recovery (CHO; placebo ingestion, active recovery (ACTIVE; placebo ingestion, passive recovery (PASSIVE. Blood lactate (BLa, blood gases, heart rate, and time to exhaustion were collected. The three high intensity bouts had a duration of 138±9, 124±6, and 121±6 s demonstrating a decrease from bout 1 to bout 3. Supplementation strategy had no effect on performance in the first bout, even with differences in pH and bicarbonate (HCO3-. Repeated sprint performance was not affected by supplementation strategy when compared to ACTIVE, while PASSIVE resulted in a more pronounced decrease in performance compared with all other interventions. BIC led to greater BLa, pH, and HCO3- values compared with all other interventions, while for PASSIVE the opposite was found. BLa recovery was lowest in PASSIVE; recovery in pH, and HCO3- was lower in PASSIVE and higher in BIC.

  8. Nutritional strategies to support adaptation to high-intensity interval training in team sports.

    Science.gov (United States)

    Gibala, Martin J

    2013-01-01

    Team sports are characterized by intermittent high-intensity activity patterns. Typically, play consists of short periods of very intense or all-out efforts interspersed with longer periods of low-intensity activity. Fatigue is a complex, multi-factorial process, but intense intermittent exercise performance can potentially be limited by reduced availability of substrates stored in skeletal muscle and/or metabolic by-products associated with fuel breakdown. High-intensity interval training (HIT) has been shown to induce adaptations in skeletal muscle that enhance the capacity for both oxidative and non-oxidative metabolism. Nutrient availability is a potent modulator of many acute physiological responses to exercise, including various molecular signaling pathways that are believed to regulate cellular adaptation to training. Several nutritional strategies have also been reported to acutely alter metabolism and enhance intermittent high-intensity exercise performance. However, relatively little is known regarding the effect of chronic interventions, and whether supplementation over a period of weeks or months augments HIT-induced physiological remodeling and promotes greater performance adaptations. Theoretically, a nutritional intervention could augment HIT adaptation by improving energy metabolism during exercise, which could facilitate greater total work and an enhanced chronic training stimulus, or promoting some aspect of the adaptive response during recovery, which could lead to enhanced physiological adaptations over time.

  9. Postprandial lipoprotein profile in two modes of high-intensity intermittent exercise

    Science.gov (United States)

    Panissa, Valéria Leme Gonçalves; Julio, Ursula Ferreira; Diniz, Tiego Aparecido; de Moura Mello Antunes, Barbara; Lira, Fabio Santos; Takito, Monica Yuri; Franchini, Emerson

    2016-01-01

    The aim of present study was to compare blood lipid postprandial profile response in two modes of high-intensity intermittent exercise. Twelve individuals (6 men and 6 women) were submitted to a maximal incremental test (to determine maximal aerobic power [MAP] and V. O2peak [peak oxygen uptake]), high-intensity intermittent all-out exercise (60×8-sec bouts interspersed by 12-sec passive recovery) and fixed high-intensity intermittent exercise (100% maximal aerobic speed, consisted of 1-min repetitions at MAP [70 rpm] separated by 1-min of passive recovery). Blood samples were collected pre, immediately, 45 and 90-min postexercise. Serum was analyzed for total cholesterol and its ratio, high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), very low-density lipoprotein (VLDL) cholesterol, and triacylglycerol (TAG). For TAG there was a main effect of moment with higher values immediately postexercise compared to 45-min postexercise. For VLDL there was a main effect to moment with higher values immediately post exercise than pre and 45-min postexercise; higher values 90-min postexercise than 45-min postexercise. There was no effect for HDL-c, LDL-c, and cholesterol. For area under the curve there was no difference for any variable. Our results indicated that both kinds of acute exercise session lead to no improvement in the acute response of serum lipid profile of healthy young. PMID:27807528

  10. Dose estimation and shielding calculation for X-ray hazard at high intensity laser facilities

    Science.gov (United States)

    Qiu, Rui; Zhang, Hui; Yang, Bo; James, C. Liu; Sayed, H. Rokni; Michael, B. Woods; Li, Jun-Li

    2014-12-01

    An ionizing radiation hazard produced from the interaction between high intensity lasers and solid targets has been observed. Laser-plasma interactions create “hot” electrons, which generate bremsstrahlung X-rays when they interact with ions in the target. However, up to now only limited studies have been conducted on this laser-induced radiological protection issue. In this paper, the physical process and characteristics of the interaction between high intensity lasers and solid targets are analyzed. The parameters of the radiation sources are discussed, including the energy conversion efficiency from laser to hot electrons, hot electron energy spectrum and electron temperature, and the bremsstrahlung X-ray energy spectrum produced by hot electrons. Based on this information, the X-ray dose generated with high-Z targets for laser intensities between 1014 and 1020 W/cm2 is estimated. The shielding effects of common shielding items such as the glass view port, aluminum chamber wall and concrete wall are also studied using the FLUKA Monte Carlo code. This study provides a reference for the dose estimation and the shielding design of high intensity laser facilities.

  11. Perceptual feeling and time-of-day effects on high intensity exercise performance

    Directory of Open Access Journals (Sweden)

    MARIE CLARE MCCORMICK

    2012-01-01

    Full Text Available The present study was designed to investigate the effect of time of day and perceptual feeling on high intensity cycle ergometry and related performance during ‘normal working hours’. Eleven male participants (22.9 ± 2.6yrs; 182 ± 0.06cm; 80.43 ± 14.39kg were tested over a 12 h period (08:00-20:00 h. Every hour, on the hour, participants performed a 10s maximal leg cycle ergometry test and completed an Exercise-Induced Feeling Inventory (EFI; every hour, on the half hour, they performed a standing broad jump (SBJ, hand grip test (HG and vertical jump (VJ. Participants were instructed that each test required maximum effort. The main results show that there were no significant differences during the 12h experimental period in any of the performance variables (P > 0.05. However, peak power output during the high intensity cycle ergometry and distance and height achieved during the SBJ and VJ test along with positive engagement all peaked at 19:00h. The results show that high intensity cycle ergometry and related physiological measures are not affected by the time of day during ‘normal working hours’. However, the data suggests that maximal performance is moderately affected by motivational levels of participants and therefore when using maximal exercise tests investigators should ensure that participants are highly motivated.

  12. HIGH INTENSITY EXERCISE AND FLEXIBILITY OF THE LOWER LIMBS: DOSE-EFFECT STUDY

    Directory of Open Access Journals (Sweden)

    João Rafael Valentim-Silva

    Full Text Available ABSTRACT Introduction: Sports scientists have been studying the phenomenon involving different types of exercises and their influence on other activities. Stretching exercises have a negative influence on muscular strength and power output, as do high intensity or long duration cardiovascular training. Nevertheless, several studies have found the opposite to be true Nevertheless, few investigations have studied the opposite. Objective: To determine whether high intensity power exercise influences muscular flexibility in an acute manner. Methods: A sample of forty-three male and female young adults aged between 18 and 28 years, with a mean age of 22.88 + 3.04 years, who have practiced physical activity for at least six months. To determine flexibility, the sit-and-reach test was used. For the high intensity training, a 45º leg press was used. A 10-rep movement was performed at 85% of 1 RM, in both pre- and post-tests. Statistic analysis was conducted using the ANOVA and Scheffer's post-hoc tests, with a level of significance for differences of < 0.05. Results: Comparison of the pre- and post-tests proved to be statistically significant from the baseline from the fourth to the seventh repetitions. Conclusion: Strength exercises at 85% of 1RM seem to significantly increase range of motion in an acute manner, and the growth of this range of motion has a dose-effect response.

  13. High-intensity knee extensor training restores skeletal muscle function in COPD patients.

    Science.gov (United States)

    Brønstad, Eivind; Rognmo, Oivind; Tjonna, Arnt Erik; Dedichen, Hans Henrich; Kirkeby-Garstad, Idar; Håberg, Asta K; Bjørk Ingul, Charlotte; Wisløff, Ulrik; Steinshamn, Sigurd

    2012-11-01

    Improving reduced skeletal muscle function is important for optimising exercise tolerance and quality of life in chronic obstructive pulmonary disease (COPD) patients. By applying high-intensity training to a small muscle group, we hypothesised a normalisation of muscle function. Seven patients with COPD performed 6 weeks (3 days·week(-1)) of high-intensity interval aerobic knee extensor exercise training. Five age-matched healthy individuals served as a reference group. Muscle oxygen uptake and mitochondrial respiration of the vastus lateralis muscle were measured before and after the 6-week training programme. Initial peak work and maximal mitochondrial respiration were reduced in COPD patients and improved significantly after the training programme. Peak power and maximal mitochondrial respiration in vastus lateralis muscle increased to the level of the control subjects and were mainly mediated via improved complex I respiration. Furthermore, when normalised to citrate synthase activity, no difference in maximal respiration was found either after the intervention or compared to controls, suggesting normal functioning mitochondrial complexes. The present study shows that high-intensity training of a restricted muscle group is highly effective in restoring skeletal muscle function in COPD patients.

  14. SALIVARY CORTISOL RESPONSES AND PERCEIVED EXERTION DURING HIGH INTENSITY AND LOW INTENSITY BOUTS OF RESISTANCE EXERCISE

    Directory of Open Access Journals (Sweden)

    Alison D. Egan

    2004-03-01

    Full Text Available The purpose of this study was to measure the salivary cortisol response to different intensities of resistance exercise. In addition, we wanted to determine the reliability of the session rating of perceived exertion (RPE scale to monitor resistance exercise intensity. Subjects (8 men, 9 women completed 2 trials of acute resistance training bouts in a counterbalanced design. The high intensity resistance exercise protocol consisted of six, ten-repetition sets using 75% of one repetition maximum (RM on a Smith machine squat and bench press exercise (12 sets total. The low intensity resistance exercise protocol consisted of three, ten-repetition sets at 30% of 1RM of the same exercises as the high intensity protocol. Both exercise bouts were performed with 2 minutes of rest between each exercise and sessions were repeated to test reliability of the measures. The order of the exercise bouts was randomized with least 72 hours between each session. Saliva samples were obtained immediately before, immediately after and 30 mins following each resistance exercise bout. RPE measures were obtained using Borg's CR-10 scale following each set. Also, the session RPE for the entire exercise session was obtained 30 minutes following completion of the session. There was a significant 97% increase in the level of salivary cortisol immediately following the high intensity exercise session (P<0.05. There was also a significant difference in salivary cortisol of 145% between the low intensity and high intensity exercise session immediately post-exercise (P<0.05. The low intensity exercise did not result in any significant changes in cortisol levels. There was also a significant difference between the session RPE values for the different intensity levels (high intensity 7.1 vs. low intensity 1.9 (P<0.05. The intraclass correlation coefficient for the session RPE measure was 0.95. It was concluded that the session RPE method is a valid and reliable method of

  15. Rapid response of soil fungal communities to low and high intensity fire

    Science.gov (United States)

    Smith, Jane E.; Cowan, Ariel D.; Reazin, Chris; Jumpponen, Ari

    2016-04-01

    Contemporary fires have created high-severity burn areas exceeding historical distributions in forests in the western United States. Until recently, the response of soil ecosystems to high intensity burns has been largely unknown. In complementary studies, we investigated the environmental effect of extreme soil heating, such that occurs with the complete combustion of large down wood during wildfires, on soil fungi and nutrients. We used TRFLP and next generation sequencing (Illumina MiSeq) to investigate the fungal communities. During the burning of large down wood, temperatures lethal to fungi were detected at 0-cm, 5-cm, and 10-cm depths in soils compared to 0-cm depth in soils receiving low intensity broadcast burns. We compared the soil fungal diversity in ten high intensity burned plots paired with adjacent low intensity burned plots before and one week after at 0-10 cm soil depth. Nonmetric Multidimensional Scaling (NMS) ordinations and analyses of taxon frequencies reveal a substantial community turnover and corresponding near complete replacement of the dominant basidiomycetes by ascomycetes in high intensity burns. These coarse-level taxonomic responses were primarily attributable to a few fire-responsive (phoenicoid) fungi, particularly Pyronema sp. and Morchella sp., whose frequencies increased more than 100-fold following high intensity burns. Pinus ponderosa seedlings planted one week post-burn were harvested after four months for EMF root tip analysis. We found: a) greater differences in soil properties and nutrients in high intensity burned soils compared to low intensity burned and unburned soils; b) no differences in EMF richness and diversity; and c) weak differences in community composition based on relative abundance between unburned and either burn treatments. These results confirm the combustion of large downed wood can alter the soil environment directly beneath it. However, an EMF community similar to low burned soils recolonized high

  16. Acidifying intermediate water accelerates the acidification of seawater on shelves: An example of the East China Sea

    Science.gov (United States)

    Lui, Hon-Kit; Chen, Chen-Tung Arthur; Lee, Jay; Wang, Shu-Lun; Gong, Gwo-Ching; Bai, Yan; He, Xianqiang

    2015-12-01

    This study is the first to present observed acidification rates at the shelf break of the East China Sea (ECS) and in the Okinawa Trough between 1982 and 2007. The use of apparent oxygen utilization (AOU) data to quantify the change in pH due to physical changes and changes in biological activities is demonstrated. The results thus obtained reveal that the drop in pH of the Kuroshio Intermediate Water (KIW) in the ECS is a result of not only the intrusion of atmospheric CO2, but also an increase in AOU concentration. The acidification rates caused by the increasing AOU concentration could contribute up to -0.00086±0.00017 pH unit yr-1 at 900 m in the Okinawa Trough and -0.00082±0.00057 pH unit yr-1 on the shelf break of the ECS. These values are equivalent to 54% and 51%, respectively, of the acidification rate of -0.0016 pH unit yr-1 based on an assumption of the air-sea CO2 equilibrium. When the effects of changing AOU and θ are eliminated, the acidification rate in the basin of the ECS captures the rate of change that is caused by an increase in anthropogenic CO2 concentration. In contrast, when the effects of changing AOU and θ are eliminated, the acidification rate at the shelf break is 69% higher than the rate based on an assumption of the air-sea CO2 equilibrium. Since the seawater on the shelf contains a higher proportion of the South China Sea (SCS) seawater and coastal water than does that in the Okinawa Trough, the result herein may imply that the SCS seawater, coastal water, or a combination of them suffered a higher acidification rate during the studied period. This study, to the best of the authors' knowledge, is the first to demonstrate that changing the carbonate chemistry of both incoming offshore intermediate seawater and coastal water results in the acidification of seawater on a continental shelf. The results herein reveal a situation in which the acidification of coastal seawater may be faster than expected when the reduction of pH of the

  17. Development of high quality electron beam accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Kando, Masaki; Dewa, Hideki; Kotaki, Hideyuki; Kondo, Shuji; Hosokai, Tomonao; Kanazawa, Shuhei; Yokoyama, Takashi; Nakajima, Kazuhisa [Advanced Photon Research Center, Kansai Research Establishment, Japan Atomic Energy Research Institute, Kizu, Kyoto (Japan)

    2000-03-01

    A design study on a high quality electron beam accelerator is described. This accelerator will be used for second generation experiments of laser wakefield acceleration, short x-ray generation, and other experiments of interaction of high intensity laser with an electron beam at Advanced Photon Research Center, Kansai Research Establishment, Japan Atomic Energy Research Institute. The system consists of a photocathode rf gun and a race-track microtron (RTM). To combine these two components, injection and extraction beamlines are designed employing transfer matrix and compute codes. A present status of the accelerator system is also presented. (author)

  18. Effects of high-intensity interval training on the VO2 response during severe exercise.

    Science.gov (United States)

    Duffield, Rob; Edge, Johann; Bishop, David

    2006-06-01

    This study examined the effect of high-intensity interval training on the VO2 response during severe, constant-load exercise. Prior to, and following training, 10 females (V O2 peak 37.4+/-6.0 mL kg-1 min-1) performed a graded exercise test to determine VO2 peak and lactate threshold (LT) and a 6 min cycle test (CT) at the pre-training VO2 peak intensity. Training involved high-intensity intervals (2 min work, 1 min rest) performed 3x week for 8 weeks. Breath-by-breath data from 0 to 6 min during the CT were smoothed using 5s averages and fit to a bi-exponential model starting from 20s. Training resulted in significant improvements in VO2 max (2.34+/-0.37-2.78+/-0.30 L min-1), power at VO2 max (170+/-26-204+/-25 W) and power at LT (113+/-17-136+/-20 W) (pVO2 response showed a significant increase in the amplitude of the primary phase (A1) (1396+/-103-1695+/-100 mL min-1; pVO2 (VO2 EE), with no difference (p>0.05) in the time constants of either phase or the amplitude of the slow component (318+/-67-380+/-48 mL; p=0.15). In conjunction, accumulated oxygen deficit (AOD) (43.7+/-9.8-17.2+/-2.8 mL O2 eq kg-1) and anaerobic contribution to the CT (19.4+/-4.4-7.2+/-1.2%) were significantly reduced. In contrast to previous moderate-intensity research, a high-intensity interval training program increased A1 and VO2 EE for the same absolute exercise intensity, decreasing the AOD during a severe-intensity CT.

  19. Effects of high-intensity swimming training on the bones of ovariectomized rats

    Science.gov (United States)

    Oh, Taewoong; Tanaka, Sakura; Naka, Tatsuki; Igawa, Shoji

    2016-01-01

    [Purpose] This study was performed to assess the effects of high-intensity intermittent swimming training(HIT) on bone in ovariectomized rats. [Methods] Six-week-old female Sprague-Dawley rats were randomly assigned to either sham operation or bilateral ovariectomy. After surgery, they were divided into the following four groups: 1) sham-operated sedentary (S), 2) sham-operated exercise training (SE), 3) OVX sedentary (O), 4) OVX exercise training (OE) 5) OVX given 17β-estradiol (OE2) and 6) OVX exercise training and given 17β-estradiol (OEE). SE, OE and OEE rats were used extremely high-intensity swim exercise. The rats repeated fourteen 20-s swimming bouts with a weight equivalent to 14, 15, and 16% of body weight for the first 5, the next 9, and the last 5 days, respectively. Between exercise bouts, a 10-s pause was allowed. HIT was originally designed as an exercise method; a method that very quickly induces an increase in the maximum oxygen intake (Tabata I et al., 1996). OEE and OE2 rats were subcutaneously injected ethanol with 25μg/kg body weight 17β-estradiol 3 times per week. [Results] Bone strength, bone mineral density and trabecular bone parameters were measured after a 8-weeks experimental period. Bone strength was significantly higher in the SE, OE, OE2 and OEE group compared with the O group. BV/TV was significant increase in the SE, OE groups compared with the O group. BMD showed no difference in the OE group compared with the O group. [Conclusion] This study demonstrate some beneficial effects of postmenopausal osteoporosis of high-intensity intermittent swimming training on bone structure and strength. PMID:27757386

  20. Locomotor muscle fatigue does not alter oxygen uptake kinetics during high-intensity exercise

    Directory of Open Access Journals (Sweden)

    James Hopker

    2016-10-01

    Full Text Available The slow component (VO2sc that develops during high-intensity aerobic exercise is thought to be strongly associated with locomotor muscle fatigue. We sought to experimentally test this hypothesis by pre-fatiguing the locomotor muscles used during subsequent high-intensity cycling exercise. Over two separate visits, eight healthy male participants were asked to either perform a non-metabolically stressful 100 intermittent drop-jumps protocol (pre fatigue condition or rest for 33 minutes (control condition according to a random and counterbalanced order. Locomotor muscle fatigue was quantified with 6-second maximal sprints at a fixed pedaling cadence of 90 rev·min-1. Oxygen kinetics and other responses (heart rate, capillary blood lactate concentration and rating of perceived exertion, RPE were measured during two subsequent bouts of 6 min cycling exercise at 50% of the delta between the lactate threshold and VO2max determined during a preliminary incremental exercise test. All tests were performed on the same cycle ergometer. Despite significant locomotor muscle fatigue (P = 0.03, the VO2sc was not significantly different between the pre fatigue (464 ± 301 mL·min-1 and the control (556 ± 223 mL·min-1 condition (P = 0.50. Blood lactate response was not significantly different between conditions (P = 0.48 but RPE was significantly higher following the pre-fatiguing exercise protocol compared with the control condition (P < 0.01 suggesting higher muscle recruitment. These results demonstrate experimentally that locomotor muscle fatigue does not significantly alter the VO2 kinetic response to high intensity aerobic exercise, and challenge the hypothesis that the VO2sc is strongly associated with locomotor muscle fatigue.

  1. Beetroot Juice Supplementation Improves High-Intensity Intermittent Type Exercise Performance in Trained Soccer Players

    Directory of Open Access Journals (Sweden)

    Jean Nyakayiru

    2017-03-01

    Full Text Available It has been shown that nitrate supplementation can enhance endurance exercise performance. Recent work suggests that nitrate ingestion can also increase intermittent type exercise performance in recreational athletes. We hypothesized that six days of nitrate supplementation can improve high-intensity intermittent type exercise performance in trained soccer players. Thirty-two male soccer players (age: 23 ± 1 years, height: 181 ± 1 m, weight: 77 ± 1 kg, playing experience: 15.2 ± 0.5 years, playing in the first team of a 2nd or 3rd Dutch amateur league club participated in this randomized, double-blind cross-over study. All subjects participated in two test days in which high-intensity intermittent running performance was assessed using the Yo-Yo IR1 test. Subjects ingested nitrate-rich (140 mL; ~800 mg nitrate/day; BR or a nitrate-depleted beetroot juice (PLA for six subsequent days, with at least eight days of wash-out between trials. The distance covered during the Yo-Yo IR1 was the primary outcome measure, while heart rate (HR was measured continuously throughout the test, and a single blood and saliva sample were collected just prior to the test. Six days of BR ingestion increased plasma and salivary nitrate and nitrite concentrations in comparison to PLA (p < 0.001, and enhanced Yo-Yo IR1 test performance by 3.4 ± 1.3% (from 1574 ± 47 to 1623 ± 48 m; p = 0.027. Mean HR was lower in the BR (172 ± 2 vs. PLA trial (175 ± 2; p = 0.014. Six days of BR ingestion effectively improves high-intensity intermittent type exercise performance in trained soccer players.

  2. Enhancement of antitumor vaccine in ablated hepatocellular carcinoma by high-intensity focused ultrasound

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    AIM:To investigate whether tumor debris created by high-intensity focused ultrasound(HIFU)could trigger antitumor immunity in a mouse hepatocellular carcinoma model. METHODS:Twenty C57BL/6J mice bearing H22 hepatocellular carcinoma were used to generate antitumor vaccines.Ten mice underwent HIFU ablation,and the remaining 10 mice received a sham-HIFU procedure with no ultrasound irradiation.Sixty normal mice were randomly divided into HIFU vaccine,tumor vaccine and control groups.These mice were immunized w...

  3. Using high intensity ultrasound as a tool to change the functional properties of interesterified soybean oil.

    Science.gov (United States)

    Ye, Yubin; Wagh, Ashwini; Martini, Silvana

    2011-10-12

    High intensity ultrasound (HIU) was used to change the crystallization behavior, generate small crystals, and improve the texture of a low saturated shortening (interesterified soybean oil). Samples were crystallized at different temperatures (26, 28, 30, and 32 °C) without and with the application of HIU. Different acoustic power levels (110, 72, 61, 54, and 44 W) were used. Results show that higher acoustic powers had a greater effect on crystal size reduction, induced crystallization, and generated harder, more elastic and viscous materials. These effects were more significant when HIU was applied in the presence of crystals and when the sample was crystallized at 32 °C.

  4. Ultrasound imaging and evaluation of lesion induced by High Intensity Focused Ultrasound

    Institute of Scientific and Technical Information of China (English)

    ZHONG Hui; WAN Mingxi; JIANG Yifeng; WANG Supin

    2006-01-01

    The present study was to investigate the differential imaging method for detecting HIFU (High Intensity Focused Ultrasound)-induced lesions and the estimation of variation of attenuation for lesion evaluation with log spectral difference algorithm. Experiment results of bovine muscle and liver in vitro were acquired. Several algorithms for lesion detection - Absolute Difference (AD), Sum Absolute Differences (SAD) and Sum Squared Differences (SSD) - were analyzed with several window sizes and threshold values. Then three attenuation parameters were compared to evaluate the degree of tissue damage. It was found that variation of the mean attenuation △(α) was an effective parameter to evaluate lesions.

  5. Evaluate thermal lesion using Nakagami imaging for monitoring of high-intensity focused ultrasound

    Science.gov (United States)

    Zhang, Siyuan; Li, Chong; Zhou, Fanyu; Wang, Supin; Wan, Mingxi

    2017-03-01

    High-intensity focused ultrasound (HIFU) is currently being developed as a noninvasive technique for the treatment of cancer located in various tissues. Cavitation microbubbles (MBs) have been potential to aid treatment while the acoustic posterior shadowing effects of MBs influence the accuracy for defining the location and range of ablated thermal lesions during focused ultrasound surgery when using ultrasonic monitoring imaging. This work explored the feasibility of using ultrasonic Nakagami imaging to evaluate the ablated region induced by focused ultrasound exposures at different acoustic power levels in transparent tissue-mimicking phantoms.

  6. A large aperture reflective wave-plate for high-intensity short-pulse laser experiments

    CERN Document Server

    Aurand, Bastian; Zhao, Huanyu; Kuschel, Stephan; Wünsche, Martin; Jäckel, Oliver; Heyer, Martin; Wunderlich, Frank; Kaluza, Malte C; Paulus, Gerhard G; Kuehl, Thomas

    2012-01-01

    We report on a reflective wave-plate system utilizing phase-shifting mirrors (PSM) for a continuous variation of elliptical polarization without changing the beam position and direction. The scalability of multilayer optics to large apertures and the suitability for high-intensity broad-bandwidth laser beams make reflective wave-plates an ideal tool for experiments on relativistic laser-plasma interaction. Our measurements confirm the preservation of the pulse duration and spectrum when a 30-fs Ti:Sapphire laser beam passes the system.

  7. A focusable, convergent fast-electron beam from ultra-high-intensity laser-solid interactions

    CERN Document Server

    Scott, R H H

    2015-01-01

    A novel scheme for the creation of a convergent, or focussing, fast-electron beam generated from ultra-high-intensity laser-solid interactions is described. Self-consistent particle-in-cell simulations are used to demonstrate the efficacy of this scheme in two dimensions. It is shown that a beam of fast-electrons of energy 500 keV - 3 MeV propagates within a solid-density plasma, focussing at depth. The depth of focus of the fast-electron beam is controlled via the target dimensions and focussing optics.

  8. High-Intensity Training Improves Exercise Performance in Elite Women Volleyball Players During a Competitive Season.

    Science.gov (United States)

    Purkhús, Elisabeth; Krustrup, Peter; Mohr, Magni

    2016-11-01

    Purkhús, E, Krustrup, P, and Mohr, M. High-intensity training improves exercise performance in elite women volleyball players during a competitive season. J Strength Cond Res 30(11): 3066-3072, 2016-Elite women volleyball players (n = 25; mean ± SD: age, 19 ± 5 years; height, 171 ± 7 cm; weight, 63 ± 10 kg) volunteered to participate in the study. They were randomized into a high-intensity training (HIT; n = 13) group and a control (CON; n = 12) group. In addition to the normal team training and games, HIT performed 6-10 × 30-seconds all-out running intervals separated by 3-minute recovery periods 3 times per week during a 4-week in-season period whereas CON only completed the team training sessions and games. Preintervention and postintervention, all players completed the arrowhead agility test (AAT), a repeated sprint test (RST; 5 × 30 meters separated by 25 seconds of recovery), and the Yo-Yo Intermittent Recovery level 2 test (Yo-Yo IR2) followed by a-10 minute rest period and the Yo-Yo IR1 test. Mean running distance during HIT in week 1 was 152 ± 4 m and increased (p ≤ 0.05) by 4.6% (159 ± 3 m) in week 4. The AAT performance improved (p ≤ 0.05) by 2.3% (18.87 ± 0.97-18.44 ± 1.06 seconds) and RST by 4.3% postintervention in the HIT group only. Baseline RST fatigue index was 7.0 ± 2.9 and 6.2 ± 5.0% in HIT and CON, respectively, but was lowered (p ≤ 0.05) to 2.7 ± 3.0% posttraining in HIT and remained unaltered in CON (5.5 ± 5.0%). In HIT, Yo-Yo IR2 and Yo-Yo IR1 performance improved by 12.6 and 18.3% postintervention, respectively, with greater (p ≤ 0.05) Yo-yo IR1 change scores than in CON. In conclusion, additional high-intensity in-season training performed as interval running improved agility, repeated sprint ability, and high-intensity intermittent exercise performance in elite women volleyball players.

  9. Reactor target from metal chromium for "pure" high-intensive artificial neutrino source

    Science.gov (United States)

    Gavrin, V. N.; Kozlova, Yu. P.; Veretenkin, E. P.; Logachev, A. V.; Logacheva, A. I.; Lednev, I. S.; Okunkova, A. A.

    2017-01-01

    The paper presents the first results of development of manufacturing technology of metallic chromium targets from highly enriched isotope 50Cr for irradiation in a high flux nuclear reactor to obtain a compact high intensity neutrino source with low content of radionuclide impurities and minimum losses of enriched isotope. The main technological stages are the hydrolysis of chromyl fluoride, the electrochemical reduction of metallic chromium, the hot isostatic pressing of chromium powder and the electrical discharge machining of chromium bars. The technological stages of hot isostatic pressing of chromium powder and of electrical discharge machining of Cr rods have been tested.

  10. HIGH INTENSITY FOCUSED ULTRASOUND FOR TREATMENT UNRESECTABLE MALIGNANT TUMORS IN 75 PATIENTS

    Institute of Scientific and Technical Information of China (English)

    郑国强

    2004-01-01

    Objective: To study preliminary experience of high intensity focused ultrasound (HIFU) for unresectable malignant tumors in 75 patients. Methods: The clinical data of 75 patients with unresectable tumor was analyzed retrospectively. Results: Among 75 patients, ten out of 57 cases achieved good local control in short-term, 5 patients liver tumor, 4 patients with tumor in the chest wall and one patient with bone matestics. Seven patients had skin burn and 2 patients developed intestinal perforations. Conclusion: HIFU is a novel tool for local tumor treatment. HIFU treatment for patients with unresectable tumor in the chest wall is effective.

  11. Th.P-19. Collisional effects and dynamic aperture in high-intensity storage rings

    Energy Technology Data Exchange (ETDEWEB)

    Benedetti, C. [Dipartimento di Fisica Universita di Bologna and INFN, Via Irnerio 46, Bologna 40126 (Italy)]. E-mail: benedetti@bo.infn.it; Rambaldi, S. [Dipartimento di Fisica Universita di Bologna and INFN, Via Irnerio 46, Bologna 40126 (Italy); Turchetti, G. [Dipartimento di Fisica Universita di Bologna and INFN, Via Irnerio 46, Bologna 40126 (Italy)

    2005-05-21

    We analyze the dynamic aperture in the presence of strong sextupolar errors for a high-intensity beam. The scaling laws for the short-term dynamic aperture are examined and its dependence on the perveance is discussed in a mean field approximation for a coasting beam. The collisional effects of Coulombian interaction are estimated for a linear lattice using a scaling law for the relaxation time. The collisional effects on the long-time dynamic aperture are discussed by comparing the results of full Hamiltonian integration with a mean field theory. An application to a storage ring with the HIDIF parameters is briefly outlined.

  12. Start-to-end simulations for the proposed Fermilab high intensity proton source

    Energy Technology Data Exchange (ETDEWEB)

    Carneiro, Jean-Paul; Johnson, D.E.; Webber, R.C.; /Fermilab

    2007-06-01

    A High Intensity Proton Source consisting in an 8 GeV superconducting H-minus linac and transfer line to the Main Injector has been proposed. The primary mission is to increase the intensity of the Fermilab Main Injector for the production of neutrino superbeams. Start-to-end simulations from the RFQ to the stripping foil using the simulation code TRACK (ANL) is presented in this paper. In particular, we will study the impact of jitter errors on the H-minus phase space at the stripping foil.

  13. Salutary effects of high-intensity interval training in persons with elevated cardiovascular risk.

    Science.gov (United States)

    Fleg, Jerome L

    2016-01-01

    Although moderate-intensity continuous training (MICT) has been the traditional model for aerobic exercise training for over four decades, a growing body of literature has demonstrated equal if not greater improvement in aerobic capacity and similar beneficial effects on body composition, glucose metabolism, blood pressure, and quality of life from high-intensity interval training (HIIT). An advantage of HIIT over MICT is the shorter time required to perform the same amount of energy expenditure. The current brief review summarizes the effects of HIIT on peak aerobic capacity and cardiovascular risk factors in healthy adults and those with various cardiovascular diseases, including coronary artery disease, chronic heart failure, and post heart transplantation.

  14. High intensity compact Compton X-ray sources: Challenges and potential of applications

    Energy Technology Data Exchange (ETDEWEB)

    Jacquet, M., E-mail: mjacquet@lal.in2p3.fr

    2014-07-15

    Thanks to the exceptional development of high power femtosecond lasers in the last 15 years, Compton based X-ray sources are in full development over the world in the recent years. Compact Compton sources are able to combine the compactness of the instrument with a beam of high intensity, high quality, tunable in energy. In various fields of applications such as biomedical science, cultural heritage preservation and material science researches, these sources should provide an easy working environment and the methods currently used at synchrotrons could be largely developed in a lab-size environment as hospitals, labs, or museums.

  15. New initiatives on lepton flavor violation and neutrino oscillation with high intense muon and neutrino sources

    CERN Document Server

    Kuno, Yoshitaka; Pakvasa, Sandip

    2002-01-01

    The area of physics involving muons and neutrinos has become exciting in particle physics. Using their high intensity sources, physicists undertake, in various ways, extensive searches for new physics beyond the Standard Model, such as tests of supersymmetric grand unification (SUSY-GUT) and precision measurements of the muon and neutrino properties, which will in future extend to ambitious studies such as determination of the three-generation neutrino mixing matrix elements and CP violation in the lepton sector. The physics of this field is advancing, with potential improvements of the source

  16. Development of a cryogenic hydrogen microjet for high-intensity, high-repetition rate experiments

    Science.gov (United States)

    Kim, J. B.; Göde, S.; Glenzer, S. H.

    2016-11-01

    The advent of high-intensity, high-repetition-rate lasers has led to the need for replenishing targets of interest for high energy density sciences. We describe the design and characterization of a cryogenic microjet source, which can deliver a continuous stream of liquid hydrogen with a diameter of a few microns. The jet has been imaged at 1 μm resolution by shadowgraphy with a short pulse laser. The pointing stability has been measured at well below a mrad, for a stable free-standing filament of solid-density hydrogen.

  17. Design and construction of a reverberation chamber for high-intensity acoustic testing.

    Science.gov (United States)

    Slusser, R. A.

    1973-01-01

    A high-intensity acoustic test facility was constructed at the Jet Propulsion Laboratory (JPL) to support the Mariner Mars 1971 project. For ease of construction, the reverberation chamber itself is rectangular, which resulted in very little sacrifice in acoustic performance. Levels as high as 156 dB can be achieved with the chamber empty and test levels of 150 dB have been used with a Mariner Mars spacecraft model (full size) in the chamber. Levels as high as this must be generated using electropneumatic transducers, which modulate gaseous nitrogen to this facility.

  18. The effect of high-intensity intermittent exercise on body composition of overweight young males.

    Science.gov (United States)

    Heydari, M; Freund, J; Boutcher, S H

    2012-01-01

    To determine the effect of a 12-week high intensity intermittent exercise (HIIE) intervention on total body, abdominal, trunk, visceral fat mass, and fat free mass of young overweight males. Participants were randomly assigned to either exercise or control group. The intervention group received HIIE three times per week, 20 min per session, for 12 weeks. Aerobic power improved significantly (P 0.05) occurred in levels of insulin, HOMA-IR, and blood lipids. Twelve weeks of HIIE resulted in significant reductions in total, abdominal, trunk, and visceral fat and significant increases in fat free mass and aerobic power.

  19. Theoretical investigation of external injection schemes for laser wakefield acceleration

    NARCIS (Netherlands)

    Luttikhof, Mark Jan Hendrik

    2010-01-01

    This thesis reports on laser wakefield acceleration, a radically new approach for particle acceleration that builds on the huge electric fields that a plasma wave can provide. In this approach, an ultra-short laser pulse of high intensity is sent through a plasma. At sufficient intensity, the radiat

  20. Effectiveness of High Intensity Laser Therapy for Reduction of Pain in Knee Osteoarthritis

    Directory of Open Access Journals (Sweden)

    Anna Angelova

    2016-01-01

    Full Text Available Introduction. Osteoarthritis is the most common type of arthritis. It is the main cause of chronic musculoskeletal pain and disability among the elderly population. Aim. This is a pilot, randomized clinical study about the effect of high intensity laser therapy in patients with osteoarthritis of the knee (OA of the knee. Material and Method. 72 patients (aged between 39 and 83 years with (clinically and radiographically proved OA of the knee were included in the study. They were randomized in two groups: therapeutic (test one (n=37, 65,11 ± 1,40 (mean ± SD years old; patients were treated with HILT and control group (n=35, 64,71 ± 1,98; patients receive sham laser. Both groups had seven sessions of treatment. VAS and dolorimetry were used for assessment of pain before and after the therapy. Pedobarometric analysis (static and dynamic was used to assess comparatively the contact surface area and maximum pressure under the heel. Results. Pain levels measured by VAS and dolorimetry decreased significantly in the therapeutic group after seven days of treatment (p< 0,001. Conclusion. The results after seven days of treatment show more intensive and cumulative effect after the application of high intensity laser therapy in comparison to sham laser. This is the reason why HILT can be a method of choice in the treatment of gonarthrosis.

  1. Moderate-to-High Intensity Physical Exercise in Patients with Alzheimer's Disease

    DEFF Research Database (Denmark)

    Hoffmann, Kristine; Sobol, Nanna A; Frederiksen, Kristian S

    2016-01-01

    Background: Studies of physical exercise in patients with Alzheimer’s disease (AD) are few and results have been inconsistent. Objective: To assess the effects of a moderate-to-high intensity aerobic exercise program in patients with mild AD. Methods: In a randomized controlled trial, we recruite....... Exercise reduced neuropsychiatric symptoms in patients with mild AD, with possible additional benefits of preserved cognition in a subgroup of patients exercising with high attendance and intensity.......Background: Studies of physical exercise in patients with Alzheimer’s disease (AD) are few and results have been inconsistent. Objective: To assess the effects of a moderate-to-high intensity aerobic exercise program in patients with mild AD. Methods: In a randomized controlled trial, we recruited...... 200 patients with mild AD to a supervised exercise group (60-min sessions three times a week for 16 weeks) or to a control group. Primary outcome was changed from baseline in cognitive performance estimated by Symbol Digit Modalities Test (SDMT) in the intention-to-treat (ITT) group. Secondary...

  2. The Effect of High Intensity Intermittent Exercise on Power Output for the Upper Body

    Directory of Open Access Journals (Sweden)

    Leonie Harvey

    2015-06-01

    Full Text Available The aim of the present study was to examine and measure high intensity, intermittent upper body performance, in addition to identifying areas of the body that affect the variance in total work done during the 5 × 6 s sprint test. Fifteen males completed an upper body 5 × 6 s sprint test on a modified electro-magnetically braked cycle ergometer, which consisted of five maximal effort sprints, each 6 s in duration, separated by 24 s of passive recovery. A fly wheel braking force corresponding to 5% of the participants’ body weight was used as the implemented resistance level. Body composition was measured using dual-energy X-ray absorptiometry (DEXA. Percent (% decrement was calculated as 100 − (Total work/ideal work × 100. Significant (P < 0.05 differences were found between sprints for both absolute and relative (W, W·kg−1, W·kg−1 Lean body mass (LBM and W·kg−1 Upper body lean body mass (UBLBM peak (PP and mean (MP power. The % decrement in total work done over the five sprints was 11.4%. Stepwise multiple linear regression analysis revealed that UBLBM accounts for 87% of the variance in total work done during the upper body 5 × 6 s sprint test. These results provide a descriptive analysis of upper body, high intensity intermittent exercise, demonstrating that PP and MP output decreased significantly during the upper body 5 × 6 s sprint test.

  3. High-intensity focused ultrasound for thyroid nodule ablation: the evidence to date

    Directory of Open Access Journals (Sweden)

    Kovatcheva RD

    2017-01-01

    Full Text Available Roussanka D Kovatcheva,1 Katja Zaletel,2 1Department of Thyroid and Metabolic Bone Disorders, Clinical Center of Endocrinology, Medical University, Sofia, Bulgaria; 2Department of Nuclear Medicine, University Medical Centre Ljubljana, Ljubljana, Slovenia Abstract: Thyroid nodules are common in occurrence and most of them are benign in nature. Some of these nodules are to be treated as they continue to grow or cause undesirable symptoms. Recently, several minimally invasive thermal ablation techniques have been introduced to overcome the complications of traditional methods such as surgery. High-intensity focused ultrasound (HIFU is the latest advance in treatment modalities, which is a noninvasive procedure that permits localized target destruction without affecting the surrounding tissues. HIFU is currently used in the treatment of various solid malignant and benign tumors. The purpose of this review is to provide an introduction to the literature, principles, and advances of HIFU therapy of benign thyroid nodules, as well as to provide a discussion on its efficacy, complications, and future. Keywords: thyroid nodule, high-intensity focused ultrasound, ultrasound guidance, ablation techniques

  4. Highly intense monocycle terahertz vortex generation by utilizing a Tsurupica spiral phase plate

    Science.gov (United States)

    Miyamoto, Katsuhiko; Kang, Bong Joo; Kim, Won Tae; Sasaki, Yuta; Niinomi, Hiromasa; Suizu, Koji; Rotermund, Fabian; Omatsu, Takashige

    2016-12-01

    Optical vortex, possessing an annular intensity profile and an orbital angular momentum (characterized by an integer termed a topological charge) associated with a helical wavefront, has attracted great attention for diverse applications due to its unique properties. In particular for terahertz (THz) frequency range, several approaches for THz vortex generation, including molded phase plates consisting of metal slit antennas, achromatic polarization elements and binary-diffractive optical elements, have been recently proposed, however, they are typically designed for a specific frequency. Here, we demonstrate highly intense broadband monocycle vortex generation near 0.6 THz by utilizing a polymeric Tsurupica spiral phase plate in combination with tilted-pulse-front optical rectification in a prism-cut LiNbO3 crystal. A maximum peak power of 2.3 MW was obtained for THz vortex output with an expected topological charge of 1.15. Furthermore, we applied the highly intense THz vortex beam for studying unique nonlinear behaviors in bilayer graphene towards the development of nonlinear super-resolution THz microscopy and imaging system.

  5. Recovering limonite from Australia iron ores by flocculation-high intensity magnetic separation

    Institute of Scientific and Technical Information of China (English)

    LUO Li-qun; ZHANG Jing-sheng; YU Yong-fu

    2005-01-01

    Successful recovery of limonite from iron fines was achieved by using flocculation-high intensity magnetic separation (FIMS) and adding hydrolyzed and causticized flocculants according to the characteristic of iron fines. The separation results of the three iron samples are as follows: iron grade 66.77%-67.98% and the recovery of iron 69.26%-70.70% by the FIMS process with flocculants. The comparative results show that under the same separation conditions the FIMS process can effectively increase the recovery of iron by 10.97%-15.73%. The flowsheet results confirm the reliability of the process in a SHP high intensity magnetic separator. The concentrate product can be used as raw materials for direct reduction iron-smelting. The hydrolyzed and causticized flocculants can selectively flocculate fine feebly-magnetic iron mineral particles to increase their apparent separation sizes. The larger the separation size, the stronger the magnetic force. By comparing the separation results of the three samples it is found that among the three samples the higher the limonite content, the better the separation result. This means that the separation result relates closely to the flocculation process and the adding pattern of the flocculant.

  6. Aerobic Fitness for Young Athletes: Combining Game-based and High-intensity Interval Training.

    Science.gov (United States)

    Harrison, C B; Kinugasa, T; Gill, N; Kilding, A E

    2015-11-01

    This study compared the effect of game-based training (GT) vs. a mix of game-based training and high-intensity interval training (MT) on physical performance characteristics. 26 young athletes (13.9±0.3 years) were assigned to either GT (n=13) or MT (n=13) for 6 weeks. Game-based training consisted of 2×8-11 min 3 vs. 3 'bucketball' SSGs separated by 3 min of passive rest twice per week, while MT consisted of one SSGs session and one high-intensity session of 15 s runs at 90-95% of the speed reached at the end of the 30-15 intermittent fitness test (VIFT) interspersed with 15 s passive recovery. Peak oxygen uptake (V˙ O2peak), VIFT, jump height, and speed were assessed pre- and post-training. Following training, V˙ O2peak (5.5±3.3%; ES=large) improved after MT, whereas VIFT improved after MT (6.6±3.2%; ES, large) and GT (4.2±5.5%, ES=small). 5-m sprint improved after GT (ES=small), while 20 m sprint and jump height were unchanged. In conclusion, while MT and GT were both effective at increasing performance parameters, greater effects were seen following MT. Therefore, MT should be considered as the preferred training method for improving aerobic power in young athletes.

  7. High-intensity interval training has positive effects on performance in ice hockey players.

    Science.gov (United States)

    Naimo, M A; de Souza, E O; Wilson, J M; Carpenter, A L; Gilchrist, P; Lowery, R P; Averbuch, B; White, T M; Joy, J

    2015-01-01

    In spite of the well-known benefits that have been shown, few studies have looked at the practical applications of high-intensity interval training (HIIT) on athletic performance. This study investigated the effects of a HIIT program compared to traditional continuous endurance exercise training. 24 hockey players were randomly assigned to either a continuous or high-intensity interval group during a 4-week training program. The interval group (IG) was involved in a periodized HIIT program. The continuous group (CG) performed moderate intensity cycling for 45-60 min at an intensity that was 65% of their calculated heart rate reserve. Body composition, muscle thickness, anaerobic power, and on-ice measures were assessed pre- and post-training. Muscle thickness was significantly greater in IG (p=0.01) when compared to CG. The IG had greater values for both ∆ peak power (p<0.003) and ∆ mean power (p<0.02). Additionally, IG demonstrated a faster ∆ sprint (p<0.02) and a trend (p=0.08) for faster ∆ endurance test time to completion for IG. These results indicate that hockey players may utilize short-term HIIT to elicit positive effects in muscle thickness, power and on-ice performance.

  8. Pacing, the missing piece of the puzzle to high-intensity interval training.

    Science.gov (United States)

    Zadow, E K; Gordon, N; Abbiss, C R; Peiffer, J J

    2015-03-01

    This study examined physiological and perceptual responses to matched work high-intensity interval training using all-out and 2 even-paced methodologies. 15 trained male cyclists performed 3 interval sessions of three 3-min efforts with 3 min of active recovery between efforts. The initial interval session was completed using all-out pacing, with the following 2 sessions being completed with computer- and athlete-controlled pacing in a randomised and semi-counterbalanced manner. Computer- and athlete-controlled intervals were completed at the mean power from the corresponding interval during the all-out trial. Oxygen consumption and ratings of perceived exertion were recorded during each effort. 20 min following each session, participants completed a 4-km time trial and provided sessional rating of perceived exertion. Oxygen consumption was greater during all-out (54.1±6.6 ml.kg(-1).min(-1); pintervals. Distribution of pace throughout high-intensity interval training can influence perceptual and metabolic stress along with subsequent performance and should be considered during the prescription of such training.

  9. Study of Atomization of a Water Jet by High-Intensity Aerial Ultrasonic Waves

    Science.gov (United States)

    Ito, Youichi

    2001-05-01

    An experimental study has been carried out on the atomization of a water jet by aerially radiating it with high-intensity ultrasonic waves. A sound source that enables the linear generation of high-intensity aerial ultrasonic waves (frequency: approximately 20 kHz) is combined with a cylindrical reflection plate in order to create a standing-wave sound field. An attempt has been made to atomize a water jet of 1 mm diameter by passing it through the above sound field at a velocity of approximately 30 m/s. It has been clarified that nodes of sound pressure in the standing-wave sound field are effective for the atomization of a water jet. In addition, the atomizing phenomenon of a water jet has been observed precisely. The relation between the intensity of sound waves required for atomization and the radiation duration has also been clarified. Even the radiation of sound waves for only 2 ms atomizes water. This suggests that a very fast water jet at 300-500 m/s might be atomized.

  10. REPORT OF THE SNOWMASS M6 WORKING GROUP ON HIGH INTENSITY PROTON SOURCES.

    Energy Technology Data Exchange (ETDEWEB)

    CHOU,W.; WEI,J.

    2001-08-14

    The M6 working group had more than 40 active participants (listed in Section 4). During the three weeks at Snowmass, there were about 50 presentations, covering a wide range of topics associated with high intensity proton sources. The talks are listed in Section 5. This group also had joint sessions with a number of other working groups, including E1 (Neutrino Factories and Muon Colliders), E5 (Fixed-Target Experiments), M1 (Muon Based Systems), T4 (Particle Sources), T5 (Beam dynamics), T7 (High Performance Computing) and T9 (Diagnostics). The M6 group performed a survey of the beam parameters of existing and proposed high intensity proton sources, in particular, of the proton drivers. The results are listed in Table 1. These parameters are compared with the requirements of high-energy physics users of secondary beams in Working Groups E1 and E5. According to the consensus reached in the E1 and E5 groups, the U.S. HEP program requires an intense proton source, a 1-4 MW Proton Driver, by the end of this decade.

  11. High-intensity interval training (HIIT) for patients with chronic diseases

    Institute of Scientific and Technical Information of China (English)

    Leanna M. Ross; Ryan R. Porter; J. Larry Durstine

    2016-01-01

    Exercise training provides physiological benefits for both improving athletic performance and maintaining good health. Different exercise training modalities and strategies exist. Two common exercise strategies are high-intensity interval training (HIIT) and moderate-intensity continuous exercise training (MCT). HIIT was first used early in the 20th century and popularized later that century for improving performance of Olympic athletes. The primary premise underlying HIIT is that, compared to energy expenditure-matched MCT, a greater amount of work is performed at a higher intensity during a single exercise session which is achieved by alternating high-intensity exercise intervals with low-intensity exercise or rest intervals. Emerging research suggests that this same training method can provide beneficial effects for patients with a chronic disease and should be included in the comprehensive medical management plan. Accordingly, a major consideration in developing an individual exercise prescription for a patient with a chronic disease is the selection of an appropriate exercise strategy. In order to maximize exercise training benefits, this strategy should be tailored to the individual’s need. The focus of this paper is to provide a brief summary of the current literature regarding the use of HIIT to enhance the functional capacity of individuals with cardiovascular, pulmonary, and diabetes diseases.

  12. High-intensity interval training (HIIT for patients with chronic diseases

    Directory of Open Access Journals (Sweden)

    Leanna M. Ross

    2016-06-01

    Full Text Available Exercise training provides physiological benefits for both improving athletic performance and maintaining good health. Different exercise training modalities and strategies exist. Two common exercise strategies are high-intensity interval training (HIIT and moderate-intensity continuous exercise training (MCT. HIIT was first used early in the 20th century and popularized later that century for improving performance of Olympic athletes. The primary premise underlying HIIT is that, compared to energy expenditure-matched MCT, a greater amount of work is performed at a higher intensity during a single exercise session which is achieved by alternating high-intensity exercise intervals with low-intensity exercise or rest intervals. Emerging research suggests that this same training method can provide beneficial effects for patients with a chronic disease and should be included in the comprehensive medical management plan. Accordingly, a major consideration in developing an individual exercise prescription for a patient with a chronic disease is the selection of an appropriate exercise strategy. In order to maximize exercise training benefits, this strategy should be tailored to the individual's need. The focus of this paper is to provide a brief summary of the current literature regarding the use of HIIT to enhance the functional capacity of individuals with cardiovascular, pulmonary, and diabetes diseases.

  13. Dissimilar Physiological and Perceptual Responses Between Sprint Interval Training and High-Intensity Interval Training.

    Science.gov (United States)

    Wood, Kimberly M; Olive, Brittany; LaValle, Kaylyn; Thompson, Heather; Greer, Kevin; Astorino, Todd A

    2016-01-01

    High-intensity interval training (HIIT) and sprint interval training (SIT) elicit similar cardiovascular and metabolic adaptations vs. endurance training. No study, however, has investigated acute physiological changes during HIIT vs. SIT. This study compared acute changes in heart rate (HR), blood lactate concentration (BLa), oxygen uptake (VO2), affect, and rating of perceived exertion (RPE) during HIIT and SIT. Active adults (4 women and 8 men, age = 24.2 ± 6.2 years) initially performed a VO2max test to determine workload for both sessions on the cycle ergometer, whose order was randomized. Sprint interval training consisted of 8 bouts of 30 seconds of all-out cycling at 130% of maximum Watts (Wmax). High-intensity interval training consisted of eight 60-second bouts at 85% Wmax. Heart rate, VO2, BLa, affect, and RPE were continuously assessed throughout exercise. Repeated-measures analysis of variance revealed a significant difference between HIIT and SIT for VO2 (p HIIT (209.3 ± 40.3 kcal) vs. SIT (193.5 ± 39.6 kcal). During HIIT, subjects burned significantly more calories and reported lower perceived exertion than SIT. The higher VO2 and lower BLa in HIIT vs. SIT reflected dissimilar metabolic perturbation between regimens, which may elicit unique long-term adaptations. If an individual is seeking to burn slightly more calories, maintain a higher oxygen uptake, and perceive less exertion during exercise, HIIT is the recommended routine.

  14. The Effects of High Intensity Interval Training vs Steady State Training on Aerobic and Anaerobic Capacity

    Science.gov (United States)

    Foster, Carl; Farland, Courtney V.; Guidotti, Flavia; Harbin, Michelle; Roberts, Brianna; Schuette, Jeff; Tuuri, Andrew; Doberstein, Scott T.; Porcari, John P.

    2015-01-01

    High intensity interval training (HIIT) has become an increasingly popular form of exercise due to its potentially large effects on exercise capacity and small time requirement. This study compared the effects of two HIIT protocols vs steady-state training on aerobic and anaerobic capacity following 8-weeks of training. Fifty-five untrained college-aged subjects were randomly assigned to three training groups (3x weekly). Steady-state (n = 19) exercised (cycle ergometer) 20 minutes at 90% of ventilatory threshold (VT). Tabata (n = 21) completed eight intervals of 20s at 170% VO2max/10s rest. Meyer (n = 15) completed 13 sets of 30s (20 min) @ 100% PVO2 max/ 60s recovery, average PO = 90% VT. Each subject did 24 training sessions during 8 weeks. Results: There were significant (p HIIT protocols are time efficient, they are not superior to conventional exercise training in sedentary young adults. Key points Steady state training equivalent to HIIT in untrained students Mild interval training presents very similar physiologic challenge compared to steady state training HIIT (particularly very high intensity variants were less enjoyable than steady state or mild interval training Enjoyment of training decreases across the course of an 8 week experimental training program PMID:26664271

  15. High-intensity interval training prevents oxidant-mediated diaphragm muscle weakness in hypertensive mice.

    Science.gov (United States)

    Bowen, T Scott; Eisenkolb, Sophia; Drobner, Juliane; Fischer, Tina; Werner, Sarah; Linke, Axel; Mangner, Norman; Schuler, Gerhard; Adams, Volker

    2017-01-01

    Hypertension is a key risk factor for heart failure, with the latter characterized by diaphragm muscle weakness that is mediated in part by increased oxidative stress. In the present study, we used a deoxycorticosterone acetate (DOCA)-salt mouse model to determine whether hypertension could independently induce diaphragm dysfunction and further investigated the effects of high-intensity interval training (HIIT). Sham-treated (n = 11), DOCA-salt-treated (n = 11), and DOCA-salt+HIIT-treated (n = 15) mice were studied over 4 wk. Diaphragm contractile function, protein expression, enzyme activity, and fiber cross-sectional area and type were subsequently determined. Elevated blood pressure confirmed hypertension in DOCA-salt mice independent of HIIT (P HIIT. Myosin heavy chain (MyHC) protein expression tended to decrease (∼30%; P = 0.06) in DOCA-salt vs. sham- and DOCA-salt+HIIT mice, whereas oxidative stress increased (P HIIT further prevented direct oxidant-mediated diaphragm contractile dysfunction (P HIIT.-Bowen, T. S., Eisenkolb, S., Drobner, J., Fischer, T., Werner, S., Linke, A., Mangner, N., Schuler, G., Adams, V. High-intensity interval training prevents oxidant-mediated diaphragm muscle weakness in hypertensive mice.

  16. Ultrasound-guided tissue fractionation by high intensity focused ultrasound in an in vivo porcine liver model.

    Science.gov (United States)

    Khokhlova, Tatiana D; Wang, Yak-Nam; Simon, Julianna C; Cunitz, Bryan W; Starr, Frank; Paun, Marla; Crum, Lawrence A; Bailey, Michael R; Khokhlova, Vera A

    2014-06-03

    The clinical use of high intensity focused ultrasound (HIFU) therapy for noninvasive tissue ablation has been recently gaining momentum. In HIFU, ultrasound energy from an extracorporeal source is focused within the body to ablate tissue at the focus while leaving the surrounding organs and tissues unaffected. Most HIFU therapies are designed to use heating effects resulting from the absorption of ultrasound by tissue to create a thermally coagulated treatment volume. Although this approach is often successful, it has its limitations, such as the heat sink effect caused by the presence of a large blood vessel near the treatment area or heating of the ribs in the transcostal applications. HIFU-induced bubbles provide an alternative means to destroy the target tissue by mechanical disruption or, at its extreme, local fractionation of tissue within the focal region. Here, we demonstrate the feasibility of a recently developed approach to HIFU-induced ultrasound-guided tissue fractionation in an in vivo pig model. In this approach, termed boiling histotripsy, a millimeter-sized boiling bubble is generated by ultrasound and further interacts with the ultrasound field to fractionate porcine liver tissue into subcellular debris without inducing further thermal effects. Tissue selectivity, demonstrated by boiling histotripsy, allows for the treatment of tissue immediately adjacent to major blood vessels and other connective tissue structures. Furthermore, boiling histotripsy would benefit the clinical applications, in which it is important to accelerate resorption or passage of the ablated tissue volume, diminish pressure on the surrounding organs that causes discomfort, or insert openings between tissues.

  17. SU-E-J-04: Integration of Interstitial High Intensity Therapeutic Ultrasound Applicators On a Clinical MRI-Guided High Intensity Focused Ultrasound Treatment Planning Software Platform

    Energy Technology Data Exchange (ETDEWEB)

    Ellens, N [Johns Hopkins University, Baltimore, Maryland (United States); Partanen, A [Philips Healthcare, Andover, Massachusetts (United States); Ghoshal, G; Burdette, E [Acoustic MedSystems Inc., Savoy, IL (United States); Farahani, K [National Cancer Institute, Bethesda, MD (United States)

    2015-06-15

    Purpose: Interstitial high intensity therapeutic ultrasound (HITU) applicators can be used to ablate tissue percutaneously, allowing for minimally-invasive treatment without ionizing radiation [1,2]. The purpose of this study was to evaluate the feasibility and usability of combining multielement interstitial HITU applicators with a clinical magnetic resonance imaging (MRI)-guided focused ultrasound software platform. Methods: The Sonalleve software platform (Philips Healthcare, Vantaa, Finland) combines anatomical MRI for target selection and multi-planar MRI thermometry to provide real-time temperature information. The MRI-compatible interstitial US applicators (Acoustic MedSystems, Savoy, IL, USA) had 1–4 cylindrical US elements, each 1 cm long with either 180° or 360° of active surface. Each applicator (4 Fr diameter, enclosed within a 13 Fr flexible catheter) was inserted into a tissue-mimicking agar-silica phantom. Degassed water was circulated around the transducers for cooling and coupling. Based on the location of the applicator, a virtual transducer overlay was added to the software to assist targeting and to allow automatic thermometry slice placement. The phantom was sonicated at 7 MHz for 5 minutes with 6–8 W of acoustic power for each element. MR thermometry data were collected during and after sonication. Results: Preliminary testing indicated that the applicator location could be identified in the planning images and the transducer locations predicted within 1 mm accuracy using the overlay. Ablation zones (thermal dose ≥ 240 CEM43) for 2 active, adjacent US elements ranged from 18 mm × 24 mm (width × length) to 25 mm × 25 mm for the 6 W and 8 W sonications, respectively. Conclusion: The combination of interstitial HITU applicators and this software platform holds promise for novel approaches in minimally-invasive MRI-guided therapy, especially when bony structures or air-filled cavities may preclude extracorporeal HIFU.[1] Diederich et al

  18. Effects of anabolic steroids and high-intensity aerobic exercise on skeletal muscle of transgenic mice.

    Directory of Open Access Journals (Sweden)

    Karina Fontana

    Full Text Available In an attempt to shorten recovery time and improve performance, strength and endurance athletes occasionally turn to the illicit use of anabolic-androgenic steroids (AAS. This study evaluated the effects of AAS treatment on the muscle mass and phenotypic characteristics of transgenic mice subjected to a high-intensity, aerobic training program (5d/wk for 6 weeks. The transgenic mice (CETP(+/-LDLr(-/+ were engineered to exhibit a lipid profile closer to humans. Animals were divided into groups of sedentary (Sed and/or training (Ex mice (each treated orally with AAS or gum arabic/vehicle: Sed-C, Sed-M, ex-C, ex-M. The effects of AAS (mesterolone: M on specific phenotypic adaptations (muscle wet weight, cross-sectional area, and fiber type composition in three hindlimb muscles (soleus:SOL, tibialis anterior:TA and gastrocnemius:GAS were assessed. In order to detect subtle changes in fiber type profile, the entire range of fiber types (I, IC, IIAC, IIA, IIAD, IID, IIDB, IIB was delineated using mATPase histochemistry. Body weight gain occurred throughout the study for all groups. However, the body weight gain was significantly minimized with exercise. This effect was blunted with mesterolone treatment. Both AAS treatment (Sed-M and high-intensity, aerobic training (ex-C increased the wet weights of all three muscles and induced differential hypertrophy of pure and hybrid fibers. Combination of AAS and training (ex-M resulted in enhanced hypertrophy. In the SOL, mesterolone treatment (Sed-M and ex-M caused dramatic increases in the percentages of fiber types IC, IIAC, IIAD, IID, with concomitant decrease in IIA, but had minimal impact on fiber type percentages in the predominantly fast muscles. Overall, the AAS-induced differential adaptive changes amounted to significant fiber type transformations in the fast-to-slow direction in SOL. AAS treatment had a significant effect on muscle weights and fiber type composition in SOL, TA and GAS which was

  19. Intermittent and continuous high-intensity exercise training induce similar acute but different chronic muscle adaptations.

    Science.gov (United States)

    Cochran, Andrew J R; Percival, Michael E; Tricarico, Steven; Little, Jonathan P; Cermak, Naomi; Gillen, Jenna B; Tarnopolsky, Mark A; Gibala, Martin J

    2014-05-01

    High-intensity interval training (HIIT) performed in an 'all-out' manner (e.g. repeated Wingate tests) is a time-efficient strategy to induce skeletal muscle remodelling towards a more oxidative phenotype. A fundamental question that remains unclear, however, is whether the intermittent or 'pulsed' nature of the stimulus is critical to the adaptive response. In study 1, we examined whether the activation of signalling cascades linked to mitochondrial biogenesis was dependent on the manner in which an acute high-intensity exercise stimulus was applied. Subjects performed either four 30 s Wingate tests interspersed with 4 min of rest (INT) or a bout of continuous exercise (CONT) that was matched for total work (67 ± 7 kJ) and which required ∼4 min to complete as fast as possible. Both protocols elicited similar increases in markers of adenosine monophosphate-activated protein kinase (AMPK) and p38 mitogen-activated protein kinase activation, as well as Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) mRNA expression (main effects for time, P ≤ 0.05). In study 2, we determined whether 6 weeks of the CONT protocol (3 days per week) would increase skeletal muscle mitochondrial content to a similar extent to what we have previously reported after 6 weeks of INT. Despite similar acute signalling responses to the CONT and INT protocols, training with CONT did not increase the maximal activity or protein content of a range of mitochondrial markers. However, peak oxygen uptake was higher after CONT training (from 45.7 ± 5.4 to 48.3 ± 6.5 ml kg(-1) min(-1); P muscle adaptations to low-volume, all-out HIIT. Despite the lack of skeletal muscle mitochondrial adaptations, our data show that a training programme based on a brief bout of high-intensity exercise, which lasted <10 min per session including warm-up, and performed three times per week for 6 weeks, improved peak oxygen uptake in young healthy subjects.

  20. Five Weeks of Sprint and High-Intensity Interval Training Improves Paddling Performance in Adolescent Surfers.

    Science.gov (United States)

    Farley, Oliver R L; Secomb, Josh L; Parsonage, Joanna R; Lundgren, Lina E; Abbiss, Chris R; Sheppard, Jeremy M

    2016-09-01

    Farley, ORL, Secomb, JL, Parsonage, JR, Lundgren, LE, Abbiss, CR, and Sheppard, JM. Five weeks of sprint and high-intensity interval training improves paddling performance in adolescent surfers. J Strength Cond Res 30(9): 2446-2452, 2016-The purpose of our study was to examine the effects of sprint interval training (SIT; 10 seconds) and high-intensity interval training (HIT; 30 seconds) on surfing athletes paddling performance (400-m time trial and repeat-sprint paddle performance). Twenty-four competitive adolescent surfers (19 male, 5 female; age = 14.4 ± 1.3 years, mass: 50.1 ± 10.7 kg, and stature: 159.9 ± 10.3 cm) were assigned to perform either 5 weeks of SIT and HIT. Participants completed a repeated-sprint paddle ability test (RSPT, 15-m surfboard sprint paddle initiated every 40 seconds × 10 bouts) and 400-m endurance surfboard paddle time trial before and after training. High-intensity interval training decreased the total time to complete the 400 m by 15.8 ± 16.1 seconds (p = 0.03), and SIT decreased the total time to complete the RSPT by 6.5 ± 4.3 seconds (p = 0.02). Fatigue index during the RSPT (first-slowest effort) was lower after HIT and SIT (p ≤ 0.001 and p = 0.02, respectively). There were no significant differences in performance changes in the 400 m (total time) and RSPT (total time, fastest 15 m time, and peak velocity) between HIT and SIT. Our study indicates that HIT and SIT may be implemented to the training program of surfers to improve aerobic and repeat-sprint paddle ability, both of which are identified as key aspects of the sport. In addition, these findings indicate that 400-m paddle and RSPT can discriminate between aerobic and anaerobic training adaptations, with aerobic gains likely from HIT and anaerobic gains from SIT.

  1. The impact of brief high-intensity exercise on blood glucose levels

    Directory of Open Access Journals (Sweden)

    Adams OP

    2013-02-01

    Full Text Available O Peter AdamsFaculty of Medical Sciences, the University of the West Indies, Cave Hill Campus, St Michael, BarbadosBackground: Moderate-intensity exercise improves blood glucose (BG, but most people fail to achieve the required exercise volume. High-intensity exercise (HIE protocols vary. Maximal cycle ergometer sprint interval training typically requires only 2.5 minutes of HIE and a total training time commitment (including rest and warm up of 25 minutes per session. The effect of brief high-intensity exercise on blood glucose levels of people with and without diabetes is reviewed.Methods: HIE (≥80% maximal oxygen uptake, VO2max studies with ≤15 minutes HIE per session were reviewed.Results: Six studies of nondiabetics (51 males, 14 females requiring 7.5 to 20 minutes/week of HIE are reviewed. Two weeks of sprint interval training increased insulin sensitivity up to 3 days postintervention. Twelve weeks near maximal interval running (total exercise time 40 minutes/week improved BG to a similar extent as running at 65% VO2max for 150 minutes/week. Eight studies of diabetics (41 type 1 and 22 type 2 subjects were reviewed. Six were of a single exercise session with 44 seconds to 13 minutes of HIE, and the others were 2 and 7 weeks duration with 20 and 2 minutes/week HIE, respectively. With type 1 and 2 diabetes, BG was generally higher during and up to 2 hours after HIE compared to controls. With type 1 diabetics, BG decreased from midnight to 6 AM following HIE the previous morning. With type 2 diabetes, a single session improved postprandial BG for 24 hours, while a 2-week program reduced the average BG by 13% at 48 to 72 hours after exercise and also increased GLUT4 by 369%.Conclusion: Very brief HIE improves BG 1 to 3 days postexercise in both diabetics and nondiabetics. HIE is unlikely to cause hypoglycemia during and immediately after exercise. Larger and longer randomized studies are needed to determine the safety, acceptability, long

  2. Hormonal and Physiological Adaptations to High-Intensity Interval Training in Professional Male Canoe Polo Athletes.

    Science.gov (United States)

    Sheykhlouvand, Mohsen; Khalili, Erfan; Agha-Alinejad, Hamid; Gharaat, Mohammadali

    2016-03-01

    This study compared the effects of 2 different high-intensity interval training (HIIT) programs in professional male canoe polo athletes. Responses of peak oxygen uptake (VO2peak), ventilatory threshold (VT), peak and mean anaerobic power output (PPO and MPO), blood volume, and hormonal adaptations to HIIT were examined. Male athletes (n = 21, age: 24 ± 3 years; height: 181 ± 4 cm; mass: 85 ± 6 kg; and body fat: 12.9 ± 2.7%) were randomly assigned to one of 3 groups (N = 7): (a) (G1) interval paddling with variable volume (6, 7, 8, 9, 9, 9, 8, 7, 6 repetitions per session from first to ninth session, respectively) × 60 second at lowest velocity that elicited VO2peak (vVO2peak), 1:3 work to recovery ratio; (b) (G2) interval paddling with variable intensity (6 × 60 second at 100, 110, 120, 130, 130, 130, 120, 110, 100% vVO2peak from first to ninth session, respectively, 1:3 work to recovery); and (c) (GCON) the control group performed three 60 minutes paddling sessions (75% vVO2peak) per week for 3 weeks. High-intensity interval training resulted in significant (except as shown) increases compared with pretest, in VO2peak (G1 = +8.8% and G2 = +8.5%), heart rate at VT (b·min) (G1 = +9.7% and G2 = +5.9%) and (%maximum) (G1 = +6.9%; p = 0.29 and G2 = +6.5%), PPO (G1 = +9.7% and G2 = +12.2%), MPO (G1 = +11.1%; p = 0.29 and G2 = +16.2%), total testosterone (G1 = +29.4% and G2 = +16.7%), total testosterone/cortisol ratio (G1 = +40.9% and G2 = +28.1%), and mean corpuscular hemoglobin (G1 = +1.7% and G2 = +1.3%). No significant changes were found in GCON. High-intensity interval paddling may improve both aerobic and anaerobic performances in professional male canoe polo athletes under the conditions of this study.

  3. Ionization chambers for monitoring in high-intensity charged particle beams

    CERN Document Server

    McDonald, J; Viren, B; Diwan, M; Erwin, A R; Naples, D; Ping, H

    2003-01-01

    Radiation-hard ionization chambers were tested using an intense electron beam from the accelerator test facility at the Brookhaven National Laboratory. The detectors were designed to be used as the basic element for monitoring muons in the Main Injector Neutrino beamline at the Fermi National Accelerator Laboratory. Measurements of linearity of response, voltage dependence, and the onset of ionization saturation as a function of gap voltage were performed.

  4. Effect of acoustic streaming on tissue heating due to high-intensity focused ultrasound

    CERN Document Server

    Solovchuk, Maxim A; Thiriet, Marc; Lin, Win-Li

    2011-01-01

    The influences of blood vessels and focused location on temperature distribution during high-intensity focused ultrasound (HIFU) ablation of liver tumors is studied. A three-dimensional acoustics-thermal-fluid coupling model is employed to compute the temperature field in the hepatic cancerous region. The model is based on the linear Westervelt and bioheat equations as well as the nonlinear Navier-Stokes equations for the liver parenchyma and blood vessels. The effect of acoustic streaming is also taken into account in the present HIFU simulation study. Different blood vessel diameters and focal point locations were investigated. We found from this three-dimensional numerical study that in large blood vessels both the convective cooling and acoustic streaming can change considerably the temperature field and the thermal lesion near blood vessels. If the blood vessel is located within the beam width, both acoustic streaming and blood flow cooling effects should be taken into account. The predicted temperature ...

  5. Relationship between the exposure dose of high intensity focused ultrasound and the heated necrosis element

    Institute of Scientific and Technical Information of China (English)

    FENG Ruo; ZHANG Qiang; LI Faqi; ZHENG Xiaozheng; BAI Jin; XU Jianyi; WANG Yaojun; WANG Zhibiao

    2004-01-01

    Heated necrosis element of tissues is the basis for treating tumor by high intensity focused ultrasound (HIFU), so study on the relationship between the HIFU exposure dose and the heated necrosis element of tissues is of great significance for both HIFU clinical applications and basic research. Using Pennes and Rayleigh formulae the relationship between the exposure dose of an annular focused transducer and the heated necrosis element (I.e. Biological focused region) in a bovine liver in vitro at a depth of 2 cm is simulated in an exposure dose range with radiation sound intensity of 7000~25400 W/cm2 and exposure time of 0~20 s. The theoretical results appear to be in quite good agreement with the experimental ones. It is shown that on the basis of existing theories the heated necrosis element produced by HIFU exposure can be predicted. The deviation of the theory from the experiments under higher exposure dose has also been discussed.

  6. Comparing Particle-in-Cell QED Models for High-Intensity Laser-Plasma Interactions

    Science.gov (United States)

    Luedtke, Scott V.; Labun, Lance A.; Hegelich, Björn Manuel

    2016-10-01

    High-intensity lasers, such as the Texas Petawatt, are pushing into new regimes of laser-matter interaction, requiring continuing improvement and inclusion of new physics effects in computer simulations. Experiments at the Texas Petawatt are reaching intensity regimes where new physics-quantum electrodynamics (QED) corrections to otherwise classical plasma dynamics-becomes important. We have two particle-in-cell (PIC) codes with different QED implementations. We review the theory of photon emission in QED-strong fields, and cover the differing PIC implementations. We show predictions from the two codes and compare with ongoing experiments. This work was supported by NNSA cooperative agreement DE-NA0002008, the Defense Advanced Research Projects Agency's PULSE program (12-63-PULSE-FP014) and the Air Force Office of Scientific Research (FA9550-14-1-0045). HPC resources provided by TACC.

  7. Laser-enhanced high-intensity focused ultrasound heating in an in vivo small animal model

    Science.gov (United States)

    Jo, Janggun; Yang, Xinmai

    2016-11-01

    The enhanced heating effect during the combination of high-intensity focused ultrasound (HIFU) and low-optical-fluence laser illumination was investigated by using an in vivo murine animal model. The thighs of murine animals were synergistically irradiated by HIFU and pulsed nano-second laser light. The temperature increases in the target region were measured by a thermocouple under different HIFU pressures, which were 6.2, 7.9, and 9.8 MPa, in combination with 20 mJ/cm2 laser exposures at 532 nm wavelength. In comparison with conventional laser therapies, the laser fluence used here is at least one order of magnitude lower. The results showed that laser illumination could enhance temperature during HIFU applications. Additionally, cavitation activity was enhanced when laser and HIFU irradiation were concurrently used. Further, a theoretical simulation showed that the inertial cavitation threshold was indeed decreased when laser and HIFU irradiation were utilized concurrently.

  8. High-intensity strength training improves function of chronically painful muscles

    DEFF Research Database (Denmark)

    Andersen, Lars L; Andersen, Christoffer H; Skotte, Jørgen H

    2014-01-01

    randomized to 10 weeks of specific strength training (SST, n = 18), general fitness training (GFT, n = 16), or a reference group without physical training (REF, n = 8). Participants performed tests of 100 consecutive cycles of 2 s isometric maximal voluntary contractions (MVC) of shoulder elevation followed...... by 2 s relaxation at baseline and 10-week follow-up. RESULTS: In the case-control study, peak force, rate of force development, and rate of force relaxation as well as EMG amplitude were lower in MYA than CON throughout all 100 MVC. Muscle fiber capillarization was not significantly different between...... capacity during repetitive MVC of the trapezius muscle than healthy controls. High-intensity strength training effectively improves strength capacity during repetitive MVC of the painful trapezius muscle....

  9. A mask for high-intensity heavy-ion beams in the MAYA active target

    Energy Technology Data Exchange (ETDEWEB)

    Rodríguez-Tajes, C., E-mail: rodriguez@ganil.fr [Grand Accélérateur National d' Ions Lourds (GANIL), CEA/DSM-CNRS/IN2P3, Bvd Henri Becquerel, 14076 Caen (France); Universidade de Santiago de Compostela, E-15706 Santiago de Compostela (Spain); Pancin, J.; Damoy, S.; Roger, T.; Babo, M. [Grand Accélérateur National d' Ions Lourds (GANIL), CEA/DSM-CNRS/IN2P3, Bvd Henri Becquerel, 14076 Caen (France); Caamaño, M. [Universidade de Santiago de Compostela, E-15706 Santiago de Compostela (Spain); Farget, F.; Grinyer, G.F.; Jacquot, B.; Pérez-Loureiro, D. [Grand Accélérateur National d' Ions Lourds (GANIL), CEA/DSM-CNRS/IN2P3, Bvd Henri Becquerel, 14076 Caen (France); Ramos, D. [Universidade de Santiago de Compostela, E-15706 Santiago de Compostela (Spain); Suzuki, D. [Institut de Physique Nucléaire, Université Paris-Sud 11, CNRS/IN2P3, F-91406 Orsay (France)

    2014-12-21

    The use of high-intensity and/or heavy-ion beams in active targets and time-projection chambers is often limited by the strong ionization produced by the beam. Besides the difficulties associated with the saturation of the detector and electronics, beam-related signals may hide the physical events of interest or reduce the detector performance. In addition, space-charge effects may deteriorate the homogeneity of the electric drift field and distort the subsequent reconstruction of particle trajectories. In anticipation of future projects involving such conditions, a dedicated beam mask has been developed and tested in the MAYA active target. Experimental results with a {sup 136}Xe beam are presented.

  10. Detailed studies of Minor Actinide transmutation-incineration in high-intensity neutron fluxes

    Energy Technology Data Exchange (ETDEWEB)

    Bringer, O. [CEA/Saclay/DSM/DAPNIA, Gif-sur-Yvette (France); Al Mahamid, I. [Lawrence Berkeley National Laboratory, E.H. and S. Div., CA (United States); Blandin, C. [CEA/Cadarache/DEN/DER/SPEX, Saint-Paul-lez-Durances (France); Chabod, S. [CEA/Saclay/DSM/DAPNIA, Gif-sur-Yvette (France); Chartier, F. [CEA/Cadarache/DEN/DPC/SECR, Gif-sur-Yvette (France); Dupont, E.; Fioni, G. [CEA/Saclay/DSM/DAPNIA, Gif-sur-Yvette (France); Isnard, H. [CEA/Cadarache/DEN/DPC/SECR, Gif-sur-Yvette (France); Letourneau, A.; Marie, F. [CEA/Saclay/DSM/DAPNIA, Gif-sur-Yvette (France); Mutti, P. [Institut Laue-Langevin, Grenoble (France); Oriol, L. [CEA/Cadarache/DEN/DER/SPEX, Saint-Paul-lez-Durances (France); Panebianco, S.; Veyssiere, C. [CEA/Saclay/DSM/DAPNIA, Gif-sur-Yvette (France)

    2006-07-01

    The Mini-INCA project is dedicated to the measurement of incineration-transmutation chains and potentials of minor actinides in high-intensity thermal neutron fluxes. In this context, new types of detectors and methods of analysis have been developed. The {sup 241}Am and {sup 232}Th transmutation-incineration chains have been studied and several capture and fission cross sections measured very precisely, showing some discrepancies with existing data or evaluated data. An impact study was made on different based-like GEN-IV reactors. It underlines the necessity to proceed to precise measurements for a large number of minor-actinides that contribute to these future incineration scenarios. (authors)

  11. Investigations on the heating effect of PE-LD induced by high-intensity focused ultrasound.

    Science.gov (United States)

    Oehm, Lukas; Bach, Sascha; Majschak, Jens-Peter

    2016-08-01

    High-intensity focused ultrasound is widely applied in tissue treatment as well as for heating of solid polymer materials. Previous studies investigating the heating effect in polymer materials utilized sound transmission through water or other fluids at low HIFU power. In this study, the ultrasonic transducer possesses a solid sound conductor made of aluminum and a high HIFU power of above 100W was applied to heat solid PE-LD samples. Temperature measurements were performed by calibrated non-invasive infrared thermal imaging. A strong heating effect with heating above melting temperature and evaporation temperature within less than 1s of irradiation was observed. Furthermore, the acoustic coupling defined by the force applied by the ultrasonic applicator to the polymer material was found to be fundamental to induce the heating effect. This investigation reveals HIFU for new applications in the field of polymer processing.

  12. Simulations On Pair Creation In Collision Of γ-Beams Produced With High Intensity Lasers

    Science.gov (United States)

    Jansen, Oliver; Ribeyre, Xavier; D'Humieres, Emmanuel; Lobet, Mathieu; Jequier, Sophie; Tikhonchuk, Vladimir

    2016-10-01

    Direct production of electron-positron pairs in two photon collisions, the Breit-Wheeler process, is one of the most basic processes in the universe. However, this process has never been directly observed in the laboratory due to the lack of high intensity γ sources. For a feasibility study and for the optimisation of experimental set-ups we developed a high-performance tree-code. Different possible set-ups with MeV photon sources were discussed and compared using collision detection for huge number of particles in a quantum-electrodynamic regime. The authors acknowledge the financial support from the French National Research Agency (ANR) in the framework of ''The Investments for the Future'' programme IdEx Bordeaux - LAPHIA (ANR-10IDEX-03-02)-Project TULIMA.

  13. Fabrication of silver nanoparticles by highly intense laser irradiation of aqueous solution

    Energy Technology Data Exchange (ETDEWEB)

    Nakamura, Takahiro; Magara, Hideyuki; Herbani, Yuliati; Sato, Shunichi [Tohoku University, Institute of Multidisciplinary Research for Advanced Materials, Sendai (Japan)

    2011-09-15

    Silver (Ag) nanoparticles were fabricated by highly intense femtosecond laser irradiation of aqueous solutions of silver nitrate (AgNO{sub 3}) with various concentrations. After irradiation, a broad absorption peak at around 420 nm originating from surface plasmon resonance of Ag nanoparticles was observed in 30 and 300 mM solutions. Transmission electron microscopy revealed that Ag nanoparticles produced in 300 mM AgNO{sub 3} solution had a typical size in the range of 2 to 20 nm and a mean size of 4 nm. The addition of 1.0 x 10{sup -2} wt% polyvinylpyrrolidone as a dispersant to the 300 mM solution caused a narrower particle size distribution as well as a narrower absorption peak width after the laser irradiation. As a result, Ag nanoparticles with a mean particle size of about 2 nm were fabricated. (orig.)

  14. Cardiorespiratory responses and reduced apneic time to cold-water face immersion after high intensity exercise.

    Science.gov (United States)

    Konstantinidou, Sylvia; Soultanakis, Helen

    2016-01-01

    Apnea after exercise may evoke a neurally mediated conflict that may affect apneic time and create a cardiovascular strain. The physiological responses, induced by apnea with face immersion in cold water (10 °C), after a 3-min exercise bout, at 85% of VO2max,were examined in 10 swimmers. A pre-selected 40-s apnea, completed after rest (AAR), could not be met after exercise (AAE), and was terminated with an agonal gasp reflex, and a reduction of apneic time, by 75%. Bradycardia was evident with immersion after both, 40-s of AAR and after AAE (Pexercise without apnea was not equally elevated. The activation of neurally opposing functions as those elicited by the diving reflex after high intensity exercise may create an autonomic conflict possibly related to oxygen-conserving reflexes stimulated by the trigeminal nerve, and those elicited by exercise.

  15. Impact of high intensity exercise on muscle morphology in EAE rats

    DEFF Research Database (Denmark)

    Wens, I; Dalgas, U; Verboven, K

    2015-01-01

    paralysis (experiment 2, n=40), isokinetic foot extensor strength, cross sectional area (CSA) of tibialis anterior (TA), extensor digitorum longus (EDL) and soleus (SOL) and brain-derived neurotrophic factor (BDNF) levels were assessed. EAE reduced muscle fiber CSA of TA, EDL and SOL. In general, exercise......The impact of high-intensity exercise on disease progression and muscle contractile properties in experimental autoimmune encephalomyelitis (EAE) remains unclear. Control (CON) and EAE rats were divided into sedentary and exercise groups. Before onset (experiment 1, n=40) and after hindquarter...... was not able to affect CSA, whereas it delayed hindquarter paralysis peak. CON muscle work peaked and declined, while it remained stable in EAE. BDNF-responses were not affected by EAE or exercise. In conclusion, EAE affected CSA-properties of TA, EDL and SOL, which could, partly, explain the absence of peak...

  16. Left-Right Symmetric Models at the High-Intensity Frontier

    CERN Document Server

    Castillo-Felisola, Oscar; Helo, Juan C; Kovalenko, Sergey G; Ortiz, Sebastian E

    2015-01-01

    We study constraints on Left-Right Symmetric models from searches of semileptonic decays of $D$, $D_{s}$, $B$ mesons, mediated by heavy neutrinos $N$ with masses $m_N\\sim $ GeV that go on their mass shell leading to a resonant enhancement of the rates. Using these processes we examine, as a function of $m_N$ and $M_{W_R}$, the physics reach of the recently proposed high-intensity beam dump experiment SHiP, which is expected to produce a large sample of $D_s$ mesons. We compare these results with the corresponding reach of neutrinoless double beta decay experiments, as well as like-sign dilepton searches with displaced vertices at the LHC. We conclude that the SHiP experiment has clear advantages in probing the Left-Right Symmetric models for heavy neutrinos in the GeV mass range.

  17. Channeling of multikilojoule high-intensity laser beams in an inhomogeneous plasma

    Energy Technology Data Exchange (ETDEWEB)

    Ivancic, S. [Univ. of Rochester, Rochester, NY (United States); Haberberger, D. [Univ. of Rochester, Rochester, NY (United States); Habara, H. [Osaka Univ., Suita (Japan); Iwawaki, T. [Osaka Univ., Suita (Japan); Anderson, K. S. [Univ. of Rochester, Rochester, NY (United States); Craxton, R. S. [Univ. of Rochester, Rochester, NY (United States); Froula, D. H. [Univ. of Rochester, Rochester, NY (United States); Meyerhofer, D. D. [Univ. of Rochester, Rochester, NY (United States); Stoeckl, C. [Univ. of Rochester, Rochester, NY (United States); Tanaka, K. A. [Osaka Univ., Suita (Japan); Theobald, W. [Univ. of Rochester, Rochester, NY (United States)

    2015-05-01

    Channeling experiments were performed that demonstrate the transport of high-intensity (>10¹⁸ W/cm²), multikilojoule laser light through a millimeter-sized, inhomogeneous (~300-μm density scale length) laser produced plasma up to overcritical density, which is an important step forward for the fast-ignition concept. The background plasma density and the density depression inside the channel were characterized with a novel optical probe system. The channel progression velocity was measured, which agrees well with theoretical predictions based on large scale particle-in-cell simulations, confirming scaling laws for the required channeling laser energy and laser pulse duration, which are important parameters for future integrated fast-ignition channeling experiments.

  18. High intensity and reduced volume training attenuates stress and recovery levels in elite swimmers

    DEFF Research Database (Denmark)

    Elbe, Anne-Marie; Rasmussen, Camilla P; Nielsen, Glen;

    2016-01-01

    . The Recovery Stress Questionnaire - Sport was used to measure the swimmers' stress and recovery levels. After the 12 week intervention, the general stress level was 16.6% (2.6-30.7%; mean and 95% CI) lower and the general recovery level was 6.5% (0.7-12.4%) higher in HIT compared to the CON, after adjusting...... for baseline values. No significant effects could be observed in sports-specific stress or sports-specific recovery. The results indicate that increasing training intensity and reducing training volume for 12 weeks can reduce general stress and increase general recovery levels in competitive swimmers.......This study investigated the effect of increased high-intensity interval training (HIT) at the expense of total training volume on the stress and recovery levels of elite swimmers. Forty-one elite swimmers participated in the study and were randomly assigned to either a HIT or a control group (CON...

  19. Vortex Dynamics and Shear-Layer Instability in High-Intensity Cyclotrons

    Science.gov (United States)

    Cerfon, Antoine J.

    2016-04-01

    We show that the space-charge dynamics of high-intensity beams in the plane perpendicular to the magnetic field in cyclotrons is described by the two-dimensional Euler equations for an incompressible fluid. This analogy with fluid dynamics gives a unified and intuitive framework to explain the beam spiraling and beam breakup behavior observed in experiments and in simulations. Specifically, we demonstrate that beam breakup is the result of a classical instability occurring in fluids subject to a sheared flow. We give scaling laws for the instability and predict the nonlinear evolution of beams subject to it. Our work suggests that cyclotrons may be uniquely suited for the experimental study of shear layers and vortex distributions that are not achievable in Penning-Malmberg traps.

  20. A mask for high-intensity heavy-ion beams in the MAYA active target

    Science.gov (United States)

    Rodríguez-Tajes, C.; Pancin, J.; Damoy, S.; Roger, T.; Babo, M.; Caamaño, M.; Farget, F.; Grinyer, G. F.; Jacquot, B.; Pérez-Loureiro, D.; Ramos, D.; Suzuki, D.

    2014-12-01

    The use of high-intensity and/or heavy-ion beams in active targets and time-projection chambers is often limited by the strong ionization produced by the beam. Besides the difficulties associated with the saturation of the detector and electronics, beam-related signals may hide the physical events of interest or reduce the detector performance. In addition, space-charge effects may deteriorate the homogeneity of the electric drift field and distort the subsequent reconstruction of particle trajectories. In anticipation of future projects involving such conditions, a dedicated beam mask has been developed and tested in the MAYA active target. Experimental results with a 136Xe beam are presented.

  1. Probing vacuum birefringence using x-ray free electron and optical high-intensity lasers

    CERN Document Server

    Karbstein, Felix

    2016-01-01

    Vacuum birefringence is one of the most striking predictions of strong field quantum electrodynamics: Probe photons traversing a strong field region can indirectly sense the applied "pump" electromagnetic field via quantum fluctuations of virtual charged particles which couple to both pump and probe fields. This coupling is sensitive to the field alignment and can effectively result in two different indices of refraction for the probe photon polarization modes giving rise to a birefringence phenomenon. In this article we perform a dedicated theoretical analysis of the proposed discovery experiment of vacuum birefringence at a x-ray free electron laser/optical high-intensity laser facility. Describing both pump and probe laser pulses realistically in terms of their macroscopic electromagnetic fields, we go beyond previous analyses by accounting for various effects not considered before in this context. Our study facilitates stringent quantitative predictions and optimizations of the signal in an actual experim...

  2. Probing vacuum birefringence using x-ray free electron and optical high-intensity lasers

    Science.gov (United States)

    Karbstein, Felix; Sundqvist, Chantal

    2016-07-01

    Vacuum birefringence is one of the most striking predictions of strong field quantum electrodynamics: Probe photons traversing a strong field region can indirectly sense the applied "pump" electromagnetic field via quantum fluctuations of virtual charged particles which couple to both pump and probe fields. This coupling is sensitive to the field alignment and can effectively result in two different indices of refraction for the probe photon polarization modes giving rise to a birefringence phenomenon. In this article, we perform a dedicated theoretical analysis of the proposed discovery experiment of vacuum birefringence at an x-ray free electron laser/optical high-intensity laser facility. Describing both pump and probe laser pulses realistically in terms of their macroscopic electromagnetic fields, we go beyond previous analyses by accounting for various effects not considered before in this context. Our study facilitates stringent quantitative predictions and optimizations of the signal in an actual experiment.

  3. The Efficacy of High-Intensity Focused Ultrasound (HIFU) in Advanced Pancreatic Cancer

    Institute of Scientific and Technical Information of China (English)

    Bo Xie; Jiajun Ling; Weiming Zhang; Xueqin Huang; Jihua Zhen; Yanzhe Huang

    2008-01-01

    OBJECTIVE To observe the efficacy of high-intensity focused ultrasound (HIFU)in the treatment of late-stage pancreatic cancer.METHODS Sixteen patients with advanced pancreatic cancer received HIFU therapy.Evaluation of efficacy was made on the basis of changes in clinical symptoms and variations in the tumor echo and size.RESULTS Clinical symptoms such as pain were significantly alleviated,echo of the tumor was enhanced with B-US and the quality of life such as eating,sleeping and mental status was markedly improved;no serious complications were observed.CONCLUSION The use of HIFU in the treatment of advanced pancreatic cancer is feasible and safe.It is effective in killing the carcinoma cells and alleviaring pain.This technique may offer non-invasive therapy for the treatment of patients with late-stage pancreatic cancer.

  4. Improved highly accurate localized motion imaging for monitoring high-intensity focused ultrasound therapy

    Science.gov (United States)

    Qu, Xiaolei; Azuma, Takashi; Sugiyama, Ryusuke; Kanazawa, Kengo; Seki, Mika; Sasaki, Akira; Takeuchi, Hideki; Fujiwara, Keisuke; Itani, Kazunori; Tamano, Satoshi; Takagi, Shu; Sakuma, Ichiro; Matsumoto, Yoichiro

    2016-07-01

    Visualizing an area subjected to high-intensity focused ultrasound (HIFU) therapy is necessary for controlling the amount of HIFU exposure. One of the promising monitoring methods is localized motion imaging (LMI), which estimates coagulation length by detecting the change in stiffness. In this study, we improved the accuracy of our previous LMI by dynamic cross-correlation window (DCCW) and maximum vibration amount (MVA) methods. The DCCW method was used to increase the accuracy of estimating vibration amplitude, and the MVA method was employed to increase signal-noise ratio of the decrease ratio at the coagulated area. The qualitative comparison of results indicated that the two proposed methods could suppress the effect of noise. Regarding the results of the quantitative comparison, coagulation length was estimated with higher accuracy by the improved LMI method, and the root-mean-square error (RMSE) was reduced from 2.51 to 1.69 mm.

  5. High-intensity power-resolved radiation imaging of an operational nuclear reactor

    Science.gov (United States)

    Beaumont, Jonathan S.; Mellor, Matthew P.; Villa, Mario; Joyce, Malcolm J.

    2015-01-01

    Knowledge of the neutron distribution in a nuclear reactor is necessary to ensure the safe and efficient burnup of reactor fuel. Currently these measurements are performed by in-core systems in what are extremely hostile environments and in most reactor accident scenarios it is likely that these systems would be damaged. Here we present a compact and portable radiation imaging system with the ability to image high-intensity fast-neutron and gamma-ray fields simultaneously. This system has been deployed to image radiation fields emitted during the operation of a TRIGA test reactor allowing a spatial visualization of the internal reactor conditions to be obtained. The imaged flux in each case is found to scale linearly with reactor power indicating that this method may be used for power-resolved reactor monitoring and for the assay of ongoing nuclear criticalities in damaged nuclear reactors. PMID:26450669

  6. Self-organization of high intensity laser pulses propagating in gases

    Energy Technology Data Exchange (ETDEWEB)

    Koga, James [Japan Atomic Energy Research Inst., Kizu, Kyoto (Japan). Kansai Research Establishment

    2001-10-01

    In recent years the development of high intensity short pulse lasers has opened up wide fields of science which had previously been difficult to study. Recent experiments of short pulse lasers propagating in air have shown that these laser pulses can propagate over very long distances (up to 12 km) with little or no distortion of the pulse. Here we present a model of this propagation using a modified version of the self-organized criticality model developed for sandpiles by Bak, Tang, and Weisenfeld. The additions to the sandpile model include the formation of plasma which acts as a threshold diffusion term and self-focusing by the nonlinear index of refraction which acts as a continuous inverse diffusion. Results of this simple model indicate that a strongly self-focusing laser pulse shows self-organized critical behavior. (author)

  7. Responses of the Equatorial Ionosphere to High Intensity Long Duration Continuous Auroral Activity

    Science.gov (United States)

    Sobral, J. H. A.; Abdu, M. A.; Gonzalez, W. D.; Gonzalez, A. C.; Tsurutani, B.; Daniela, D. C.; Arruda, C. S.

    This work focus the responses of the equatorial ionosphere over South America to intense substorms and, on the other hand, in the absence of magnetic storms. The substorms here concerned are related to what is known as High Intensity Long Duration Continuous Auroral Activity HILDCAA's. The analysis of these responses are carried out by means of ground-based ionosonde data from Fortaleza (3° 53'S 38° 25'W dip 2.7S for the epoch 1978-1979) and Cachoeira Paulista (22° 41'S , 45° 00W, dip 25.6S for 1978-1979)and ISEE-3 (Interplanetary Sun-Earth Explorer) satellite data during the 1978-1979 time frame. The substorm disturbed days are compared with the averages of quiet days. The ionospheric height variations are analyzed in the light of satellite data and intercomparisons of the two stations.

  8. High intensity physical exercise and pain in the neck and upper limb among slaughterhouse workers

    DEFF Research Database (Denmark)

    Sundstrup, Emil; Jakobsen, Markus D.; Andersen, Kenneth Jay

    2014-01-01

    and pain among 595 slaughterhouse workers in Denmark, Europe. Using logistic regression analyses, odds ratios for pain and work disability as a function of physical exercise, gender, age, BMI, smoking, and job position were estimated. The prevalence of pain in the neck, shoulder, elbow, and hand....../wrist was 48%, 60%, 40%, and 52%, respectively. The odds for experiencing neck pain were significantly lower among slaughterhouse workers performing physical exercise (OR = 0.70, CI: 0.49-0.997), whereas the odds for pain in the shoulders, elbow, or hand/wrist were not associated with exercise. The present...... study can be used as general reference of pain in the neck and upper extremity among slaughterhouse workers. Future studies should investigate the effect of high intensity physical exercise on neck and upper limb pain in slaughterhouse workers....

  9. A radiation emission shielding method for high intensity focus ultrasound probes.

    Science.gov (United States)

    Wu, Hao; Shen, Guofeng; Chen, Yazhu

    2015-01-01

    Electromagnetic compatibility (EMC) is a key issue in the design and development of safe and effective medical instruments. The treatment probes of high intensity focused ultrasound (HIFU) systems not only receive and transmit electromagnetic waves, but also radiate ultrasound waves, resulting in electromagnetic coupling. In this paper, an electromagnetic shielding method involving the enclosure of the probe in a copper wire mesh was introduced. First, sound pressure distribution simulations and measurements were performed using a hydrophone in order to evaluate the effects of the wire mesh on the acoustic performance of the HIFU system. The results indicated that the wire mesh did not disturb the normalized sound pressure field. In addition, the attenuation of the maximum pressure in the focal plane was equal to 6.2%. Then, the electronic emission level was tested in a chamber. After the implementation of the wire mesh, the 10-100 MHz frequency band radiation was suppressed, and the HIFU system satisfied the national EMC standards.

  10. A Rectourethral Fistula due to Transrectal High-Intensity Focused Ultrasound Treatment: Diagnosis and Management.

    Science.gov (United States)

    Fiaschetti, Valeria; Manenti, Guglielmo; Di Poce, Isabelle; Fornari, Maria; Ricci, Aurora; Finazzi Agrò, Enrico; Simonetti, Giovanni

    2012-01-01

    Colovesical fistula (CVF) is an abnormal connection between the enteric and the urinary systems. The rectourethral fistula (RUF) is a possible but extremely rare complication of treatment of prostate cancer with "transrectal High-Intensity Focused Ultrasound (HIFU) treatment." We present a case of CVF due to HIFU treatment of recurrent prostate cancer. The case was assessed with cystography completed with a pelvic CT scan-with MPR, MIP, and VR reconstruction-before emptying the bladder. Since the CT scan confirmed that the fistula involved solely the urethra and excluded even a minimal involvement of the bladder, it was possible to employ a conservative treatment by positioning a Foley catheter of monthly duration, in order to allow the urethra to rest. Still today, after 6 months, the patient is in a good clinical condition and has not shown yet signs of a recurrence of the fistula.

  11. Removal of Liquid Leaked into Narrow Channel Using High-Intensity Aerial Ultrasonic Waves

    Science.gov (United States)

    Ito, Youichi; Kotani, Masayuki

    2004-05-01

    We tried to remove a liquid leaked into a narrow channel immediately by radiating high-intensity aerial ultrasonic waves (at a frequency of 20 kHz) onto the liquid to atomize and disperse it into the atmosphere. Channels of 0.3 to 2 mm width and 1 to 10 mm depth with and without a bottom were used. The results of experiments showed that an ultrasonic radiation of 170 dB or more could remove a liquid in each of the channels immediately, by atomizing and dispersing it. The processes of atomization and dispersion of the liquid in each channel without a bottom largely varied, depending on the channel width and depth as well as the ultrasonic radiation intensity.

  12. X-ray Absorption Imaging of High-Intensity Discharge Lamps Using Monochromatic Synchrotron Radiation

    Science.gov (United States)

    Curry, John J.; Sansonetti, Craig J.; Hechtfischer, Ulrich; Adler, Helmar G.

    2002-10-01

    We will report results from the imaging of Hg vapor in high-intensity discharge lamps using synchrotron radiation and digital detectors. These measurements extend previous work on x-ray absorption imaging in arc lamps using an x-ray tube and a passive phosphor image plate detector^i. The large x-ray flux obtained from the Advanced Photon Source (Argonne National Laboratory) combined with the electronic gating capabilities of an intensified charge-coupled device detector have allowed us to obtain time-resolved Hg distributions with high spatial resolution. Monochromatic synchrotron radiation improves the accuracy over what can be obtained with quasi-continuum radiation from an x-ray tube source. ^iJ. J. Curry, M. Sakai, and J. E. Lawler, Journal of Applied Physics 84, 3066 (1998).

  13. Optimisation extraction of chondroitin sulfate from fish bone by high intensity pulsed electric fields.

    Science.gov (United States)

    He, Guidan; Yin, Yongguang; Yan, Xiaoxia; Yu, Qingyu

    2014-12-01

    High intensity pulsed electric fields (PEF) was used to extract chondroitin sulphate (CS) from fish bone. Results show that PEF extraction speed is much faster, and the content of CS is much higher compared with traditional methods. Variation of PEF parameters and the content of CS were determined by single factor experiments. The processing conditions were optimised by quadratic general rotary unitised design experiments. The maximum yield of 6.92 g/L was achieved under the following conditions: material-liquid ratio of 1:15 g/mL, electric field intensity of 16.88 kV/cm, pulse number of 9, and NaOH concentration of 3.24%. The purity of CS was analysed by agarose gel electrophoresis. CS purity was high, and the extract did not contain any other glycosaminoglycans. PEF can be widely used to extract CS with non-thermal performance, high speed, and low pollution.

  14. Analysis of a high intensity shear zone between overlapping fiber ends in a polymer matrix composite

    DEFF Research Database (Denmark)

    Lindgreen, Britta

    2008-01-01

    The formation of high intensity shear zones in a glass fiber reinforced thermoplast is studied numerically. The thermoplast is characterized by a finite strain elastic-viscoplastic constitutive relation and the calculations are carried out using a dynamic finite element program where plane strain...... conditions are assumed to prevail in the direction of the thickness. Different ratios of the elongation strain and the transverse strain are studied to consider the effect of different levels of stress triaxiality and the effect of these states on the shear zone development and emerging strain and stress...... concentrations. Comparing a case of embedded infinitely stiff fibers to a case with glass fiber reinforcement shows little difference thus illustrating that the glass fibers act approximately as infinitely stiff. Fiber spacing and fiber width are shown to influence the shear zones and the stress fields...

  15. Backcoupling of acoustic streaming on the temperature field inside high-intensity discharge lamps

    CERN Document Server

    Schwieger, Joerg; Wolff, Marcus; Manders, Freddy; Suijker, Jos

    2015-01-01

    Operating high-intensity discharge lamps in the high frequency range (20-300 kHz) provides energy-saving and cost reduction potentials. However, commercially available lamp drivers do not make use of this operating strategy because light intensity fluctuations and even lamp destruction are possible. The reason for the fluctuating discharge arc are acoustic resonances in this frequency range that are excited in the arc tube. The acoustic resonances in turn generate a fluid flow that is caused by the acoustic streaming effect. Here, we present a 3D multiphysics model to determine the influence of acoustic streaming on the temperature field in the vicinity of an acoustic eigenfrequency. In that case a transition from stable to instable behavior occurs. The model is able to predict when light flicker can be expected. The results are in very good accordance with accompanying experiments.

  16. Real-time feedback control for high-intensity focused ultrasound system using localized motion imaging

    Science.gov (United States)

    Sugiyama, Ryusuke; Kanazawa, Kengo; Seki, Mika; Azuma, Takashi; Sasaki, Akira; Takeuchi, Hideki; Fujiwara, Keisuke; Itani, Kazunori; Tamano, Satoshi; Yoshinaka, Kiyoshi; Takagi, Shu; Matsumoto, Yoichiro

    2015-07-01

    High-intensity focused ultrasound (HIFU) is one of the noninvasive treatment for tumors. Visualizing the treated area inside the human body is necessary to control the HIFU exposure. Localized motion imaging (LMI) using ultrasound to induce and detect tissue deformation is one technique to detect a change in tissue stiffness caused by thermal coagulation. In experiments with porcine liver, LMI has shown to detect deformation with less than 20% accuracy. We have developed a prototype feedback control system using real-time LMI. In this system, coagulation size was measured every 1 s and controlled to correspond to a targeted size. The typical size error was reduced to 14% from 35%. LMI displacements in normal and coagulated tissues were sufficiently different to discriminate between coagulated areas and noncoagulated ones after HIFU sonication and to visualize treated areas after HIFU treatment.

  17. Salutary effects of high-intensity interval training in persons with elevated cardiovascular risk

    Science.gov (United States)

    Fleg, Jerome L.

    2016-01-01

    Although moderate-intensity continuous training (MICT) has been the traditional model for aerobic exercise training for over four decades, a growing body of literature has demonstrated equal if not greater improvement in aerobic capacity and similar beneficial effects on body composition, glucose metabolism, blood pressure, and quality of life from high-intensity interval training (HIIT). An advantage of HIIT over MICT is the shorter time required to perform the same amount of energy expenditure. The current brief review summarizes the effects of HIIT on peak aerobic capacity and cardiovascular risk factors in healthy adults and those with various cardiovascular diseases, including coronary artery disease, chronic heart failure, and post heart transplantation. PMID:27635241

  18. Design, construction, activation, and operation of a high intensity acoustic test chamber

    Science.gov (United States)

    Kamel, L. T.

    1986-01-01

    The design philosophy, construction, integration, and activation of the high intensity acoustic test chamber for production acceptance testing of satellites are discussed. The 32,000 cubic-foot acoustic test cell consists of a steel reinforced concrete chamber with six electropneumatic noise generators. One of the innovative features of the chamber is a unique quarter horn assembly that acoustically couples the noise generators to the chamber. Design concepts, model testing, and evaluation results are presented. Considerations such as nitrogen versus compressed air source, digital closed loop spectrum control versus manual equalizers, and microprocessor based interlock systems are included. Construction difficulties, anomalies encountered, and their resolution are also discussed. Results of the readiness testing are highlighted.

  19. High-intensity sprint training inhibits mitochondrial respiration through aconitase inactivation

    DEFF Research Database (Denmark)

    Larsen, Filip J; Schiffer, Tomas A; Ørtenblad, Niels

    2016-01-01

    Intense exercise training is a powerful stimulus that activates mitochondrial biogenesis pathways and thus increases mitochondrial density and oxidative capacity. Moderate levels of reactive oxygen species (ROS) during exercise are considered vital in the adaptive response, but high ROS production......, the mitochondrial dysfunction was compensated for by a 15-72% increase in mitochondrial proteins, whereas H2O2 emission was unchanged. In parallel with the inactivation of aconitase, the intermediary metabolite citrate accumulated and played an integral part in cellular protection against oxidative stress...... was highlighted where accumulation of citrate acted to preserve the redox status of the cell during periods of intense exercise.-Larsen, F. J., Schiffer, T. A., Ørtenblad, N., Zinner, C., Morales-Alamo, D., Willis, S. J., Calbet, J. A., Holmberg, H.-C., Boushel, R. High-intensity sprint training inhibits...

  20. [High-intensity focused ultrasound and prostate cancer: technology, state of the art and future].

    Science.gov (United States)

    Vespasiani, G; Asimakopoulos, A D; Finazzi Agrò, E; Virgili, G

    2008-01-01

    BACKGROUND. The potential applications of the high-intensity focused ultrasound (HIFU) as a minimally invasive therapy of the localized prostate cancer explain the growing interest of the urologic community towards this technique. HIFU has been assessed for its role in the treatment of localized prostate cancer in patients who otherwise would not have benefited from surgery, and in local recurrences after radiation failure. Methods. Relevant information on HIFU treatment was identified through a literature search of published studies. RESULTS. High biochemical efficacy, excellent tumor local control and favorable mid- and long-term oncological data with a low morbidity rate have been shown in many series of patients. CONCLUSIONS. Although HIFU is a recent and emerging technology, it has been well studied and developed to a point that HIFU will undoubtedly be an effective alternative to radiation therapy.

  1. A Rectourethral Fistula due to Transrectal High-Intensity Focused Ultrasound Treatment: Diagnosis and Management

    Directory of Open Access Journals (Sweden)

    Valeria Fiaschetti

    2012-01-01

    Full Text Available Colovesical fistula (CVF is an abnormal connection between the enteric and the urinary systems. The rectourethral fistula (RUF is a possible but extremely rare complication of treatment of prostate cancer with “transrectal High-Intensity Focused Ultrasound (HIFU treatment.” We present a case of CVF due to HIFU treatment of recurrent prostate cancer. The case was assessed with cystography completed with a pelvic CT scan—with MPR, MIP, and VR reconstruction—before emptying the bladder. Since the CT scan confirmed that the fistula involved solely the urethra and excluded even a minimal involvement of the bladder, it was possible to employ a conservative treatment by positioning a Foley catheter of monthly duration, in order to allow the urethra to rest. Still today, after 6 months, the patient is in a good clinical condition and has not shown yet signs of a recurrence of the fistula.

  2. Preoperative high-intensity training in frail old patients undergoing pulmonary resection for NSCLC

    Directory of Open Access Journals (Sweden)

    Salvi Rosario

    2016-01-01

    Full Text Available Thoracic surgery remains the better therapeutic option for non-small cell lung cancer patients that are diagnosed in early stage disease. Preoperative lung function assessment includes respiratory function tests (RFT and cardio-pulmonary exercise testing (CPET. Vo2 peak, FEV1 and DLCO as well as recognition of performance status, presence of co-morbidities, frailty indexes, and age predict the potential impact of surgical resection on patient health status and survival risk. In this study we have retrospectively assessed the benefit of a high-intensity preoperative pulmonary rehabilitation program (PRP in 14 patients with underlying lung function impairment prior to surgery. Amongst these, three patients candidate to surgical resection exhibited severe functional impairment associated with high score of frailty according CHS and SOF index, resulting in a substantial mortality risk.

  3. The Fermilab Main Injector: high intensity operation and beam loss control

    CERN Document Server

    Brown, Bruce C; Capista, David; Chou, Weiren; Kourbanis, Ioanis; Morris, Denton K; Seiya, Kiyomi; Wu, Guan Hong; Yang, Ming-Jen

    2013-01-01

    From 2005 through 2012, the Fermilab Main Injector provided intense beams of 120 GeV protons to produce neutrino beams and antiprotons. Hardware improvements in conjunction with improved diagnostics allowed the system to reach sustained operation at ~400 kW beam power. Transmission was very high except for beam lost at or near the 8 GeV injection energy where 95% beam transmission results in about 1.5 kW of beam loss. By minimizing and localizing loss, residual radiation levels fell while beam power was doubled. Lost beam was directed to either the collimation system or to the beam abort. Critical apertures were increased while improved instrumentation allowed optimal use of available apertures. We will summarize the improvements required to achieve high intensity, the impact of various loss control tools and the status and trends in residual radiation in the Main Injector.

  4. Carbon Fiber Damage in Accelerator Beam

    CERN Document Server

    Sapinski, M; Guerrero, A; Koopman, J; Métral, E

    2009-01-01

    Carbon fibers are commonly used as moving targets in Beam Wire Scanners. Because of their thermomechanical properties they are very resistant to particle beams. Their strength deteriorates with time due to radiation damage and low-cycle thermal fatigue. In case of high intensity beams this process can accelerate and in extreme cases the fiber is damaged during a single scan. In this work a model describing the fiber temperature, thermionic emission and sublimation is discussed. Results are compared with fiber damage test performed on SPS beam in November 2008. In conclusions the limits of Wire Scanner operation on high intensity beams are drawn.

  5. High-Intensity Interval Training in Patients with Substance Use Disorder

    Directory of Open Access Journals (Sweden)

    Grete Flemmen

    2014-01-01

    Full Text Available Patients with substance use disorder (SUD suffer a higher risk of cardiovascular disease and other lifestyle diseases compared to the general population. High intensity training has been shown to effectively reduce this risk, and therefore we aimed to examine the feasibility and effect of such training in SUD patients in clinical treatment in the present study. 17 males and 7 females (32 ± 8 yr in treatment were randomized to either a training group (TG, treadmill interval training in 4 × 4 minutes at 90–95% of maximal heart rate, 3 days a week for 8 weeks, or a conventional rehabilitation control group (CG. Baseline values for both groups combined at inclusion were 44 ± 8 (males and 34 ± 9 (females mL · min−1 · kg−1, respectively. 9/12 and 7/12 patients completed the TG and CG, respectively. Only the TG significantly improved (15 ± 7% their maximal oxygen consumption (VO2max, from 42.3 ± 7.2 mL · min−1 · kg−1 at pretest to 48.7 ± 9.2 mL · min−1 · kg−1 at posttest. No between-group differences were observed in work economy, and level of insomnia (ISI or anxiety and depression (HAD, but a significant within-group improvement in depression was apparent for the TG. High intensity training was feasible for SUD patients in treatment. This training form should be implemented as a part of the rehabilitation since it, in contrast to the conventional treatment, represents a risk reduction for cardiovascular disease and premature death.

  6. EFFECT OF HIGH-INTENSITY EXERCISE ON ENDOTHELIAL FUNCTION IN PATIENTS WITH T2DM

    Directory of Open Access Journals (Sweden)

    Carlos Alberto da Silva

    2016-04-01

    Full Text Available Introduction: Diabetes mellitus is the most common metabolic disease worldwide. Endothelial dysfunction characteristic of these patients is one of the major risk factors for atherosclerosis. Early diagnosis of endothelial dysfunction is essential for the treatment especially of non-invasive manner, such as flow mediated dilation. Physical exercise is capable of generating beneficial adaptations may improve endothelial function. Objective: Identify the effect of physical exercise, using the clinical technique of ultrasound in the assessment of the endothelial function of patients with metabolic syndrome or type 2 diabetes mellitus. Methods: Thirty-one patients with type 2 diabetes mellitus or metabolic syndrome were studied, with a mean age (± SD of 58±6 years, randomized into three groups. The training was performed for 50 minutes, four times a week. Before and after six weeks of training, subjects performed the endurance test and a study of the endothelial function of the brachial artery by high-resolution ultrasound. Results: After hyperemia, the percentage of arterial diameter was significantly higher for the high-intensity group (HI before = 2.52±2.85mm and after = 31.81±12.21mm; LI before = 3.23±3.52mm and after = 20.61±7.76mm; controls before = 3.56±2.33mm and after = 2.43±2.14mm; p<0.05. Conclusions: The high-intensity aerobic training improved the vasodilatation response-dependent endothelium, recorded by ultrasound, in patients with metabolic syndrome and type 2 diabetes.

  7. Extremely short duration high intensity interval training substantially improves insulin action in young healthy males

    Directory of Open Access Journals (Sweden)

    Cottrell Greg

    2009-01-01

    Full Text Available Abstract Background Traditional high volume aerobic exercise training reduces cardiovascular and metabolic disease risk but involves a substantial time commitment. Extremely low volume high-intensity interval training (HIT has recently been demonstrated to produce improvements to aerobic function, but it is unknown whether HIT has the capacity to improve insulin action and hence glycemic control. Methods Sixteen young men (age: 21 ± 2 y; BMI: 23.7 ± 3.1 kg·m-2; VO2peak: 48 ± 9 ml·kg-1·min-1 performed 2 weeks of supervised HIT comprising of a total of 15 min of exercise (6 sessions; 4–6 × 30-s cycle sprints per session. Aerobic performance (250-kJ self-paced cycling time trial, and glucose, insulin and NEFA responses to a 75-g oral glucose load (oral glucose tolerance test; OGTT were determined before and after training. Results Following 2 weeks of HIT, the area under the plasma glucose, insulin and NEFA concentration-time curves were all reduced (12%, 37%, 26% respectively, all P -1, P = 0.058. Insulin sensitivity, as measured by the Cederholm index, was improved by 23% (P Conclusion The efficacy of a high intensity exercise protocol, involving only ~250 kcal of work each week, to substantially improve insulin action in young sedentary subjects is remarkable. This novel time-efficient training paradigm can be used as a strategy to reduce metabolic risk factors in young and middle aged sedentary populations who otherwise would not adhere to time consuming traditional aerobic exercise regimes.

  8. Optical Frequency Optimization of a High Intensity Laser Power Beaming System Utilizing VMJ Photovoltaic Cells

    Science.gov (United States)

    Raible, Daniel E.; Dinca, Dragos; Nayfeh, Taysir H.

    2012-01-01

    An effective form of wireless power transmission (WPT) has been developed to enable extended mission durations, increased coverage and added capabilities for both space and terrestrial applications that may benefit from optically delivered electrical energy. The high intensity laser power beaming (HILPB) system enables long range optical 'refueling" of electric platforms such as micro unmanned aerial vehicles (MUAV), airships, robotic exploration missions and spacecraft platforms. To further advance the HILPB technology, the focus of this investigation is to determine the optimal laser wavelength to be used with the HILPB receiver, which utilizes vertical multi-junction (VMJ) photovoltaic cells. Frequency optimization of the laser system is necessary in order to maximize the conversion efficiency at continuous high intensities, and thus increase the delivered power density of the HILPB system. Initial spectral characterizations of the device performed at the NASA Glenn Research Center (GRC) indicate the approximate range of peak optical-to-electrical conversion efficiencies, but these data sets represent transient conditions under lower levels of illumination. Extending these results to high levels of steady state illumination, with attention given to the compatibility of available commercial off-the-shelf semiconductor laser sources and atmospheric transmission constraints is the primary focus of this paper. Experimental hardware results utilizing high power continuous wave (CW) semiconductor lasers at four different operational frequencies near the indicated band gap of the photovoltaic VMJ cells are presented and discussed. In addition, the highest receiver power density achieved to date is demonstrated using a single photovoltaic VMJ cell, which provided an exceptionally high electrical output of 13.6 W/sq cm at an optical-to-electrical conversion efficiency of 24 percent. These results are very promising and scalable, as a potential 1.0 sq m HILPB receiver of

  9. Light-intensity and high-intensity interval training improve cardiometabolic health in rats.

    Science.gov (United States)

    Batacan, Romeo B; Duncan, Mitch J; Dalbo, Vincent J; Connolly, Kylie J; Fenning, Andrew S

    2016-09-01

    Physical activity has the potential to reduce cardiometabolic risk factors but evaluation of different intensities of physical activity and the mechanisms behind their health effects still need to be fully established. This study examined the effects of sedentary behaviour, light-intensity training, and high-intensity interval training on biometric indices, glucose and lipid metabolism, inflammatory and oxidative stress markers, and vascular and cardiac function in adult rats. Rats (12 weeks old) were randomly assigned to 1 of 4 groups: control (CTL; no exercise), sedentary (SED; no exercise and housed in small cages to reduce activity), light-intensity trained (LIT; four 30-min exercise bouts/day at 8 m/min separated by 2-h rest period, 5 days/week), and high-intensity interval trained (HIIT, four 2.5-min work bouts/day at 50 m/min separated by 3-min rest periods, 5 days/week). After 12 weeks of intervention, SED had greater visceral fat accumulation (p < 0.01) and slower cardiac conduction (p = 0.04) compared with the CTL group. LIT and HIIT demonstrated beneficial changes in body weight, visceral and epididymal fat weight, glucose regulation, low-density lipoprotein cholesterol, total cholesterol, and mesenteric vessel contractile response compared with the CTL group (p < 0.05). LIT had significant improvements in insulin sensitivity and cardiac conduction compared with the CTL and SED groups whilst HIIT had significant improvements in systolic blood pressure and endothelium-independent vasodilation to aorta and mesenteric artery compared with the CTL group (p < 0.05). LIT and HIIT induce health benefits by improving traditional cardiometabolic risk factors. LIT improves cardiac health while HIIT promotes improvements in vascular health.

  10. Effects of high-intensity interval training on cardiometabolic risk factors in overweight/obese women.

    Science.gov (United States)

    Smith-Ryan, Abbie E; Trexler, Eric T; Wingfield, Hailee L; Blue, Malia N M

    2016-11-01

    The purpose of this study was to evaluate two practical interval training protocols on cardiorespiratory fitness, lipids and body composition in overweight/obese women. Thirty women (mean ± SD; weight: 88.1 ± 15.9 kg; BMI: 32.0 ± 6.0 kg · m(2)) were randomly assigned to ten 1-min high-intensity intervals (90%VO2 peak, 1 min recovery) or five 2-min high-intensity intervals (80-100% VO2 peak, 1 min recovery) or control. Peak oxygen uptake (VO2 peak), peak power output (PPO), body composition and fasting blood lipids were evaluated before and after 3 weeks of training, completed 3 days per week. Results from ANCOVA analyses demonstrated no significant training group differences for any primary variables (P > 0.05). When training groups were collapsed, 1MIN and 2MIN resulted in a significant increase in PPO (∆18.9 ± 8.5 watts; P = 0.014) and time to exhaustion (∆55.1 ± 16.4 s; P = 0.001); non-significant increase in VO2 peak (∆2.36 ± 1.34 ml · kg(-)(1) · min(-)(1); P = 0.185); and a significant decrease in fat mass (FM) (-∆1.96 ± 0.99 kg; P = 0.011). Short-term interval exercise training may be effective for decreasing FM and improving exercise tolerance in overweight and obese women.

  11. The effect of warm-up on high-intensity, intermittent running using nonmotorized treadmill ergometry.

    Science.gov (United States)

    Brown, Peter I; Hughes, Michael G; Tong, Richard J

    2008-05-01

    The aim of this study was to investigate the effect of previous warming on high-intensity intermittent running using nonmotorized treadmill ergometry. Ten male soccer players completed a repeated sprint test (10 x 6-second sprints with 34-second recovery) on a nonmotorized treadmill preceded by an active warm-up (10 minutes of running: 70% VO2max; mean core temperature (Tc) 37.8 +/- 0.2 degrees C), a passive warm-up (hot water submersion: 40.1 +/- 0.2 degrees C until Tc reached that of the active warm-up; 10 minutes +/- 23 seconds), or no warm-up (control). All warm-up conditions were followed by a 10-minute static recovery period with no stretching permitted. After the 10-minute rest period, Tc was higher before exercise in the passive trial (38.0 +/- 0.2 degrees C) compared to the active (37.7 +/- 0.4 degrees C) and control trials (37.2 +/- 0.2 degrees C; p pre-exercise oxygen consumption and blood lactate concentration; however, heart rate was greater in the active trial (p 0.05), although both were greater than the control. The percentage of decrement in performance fatigue was similar between all conditions (active, 3.4 +/- 1.3%; passive, 4.0 +/- 2.0%; and control, 3.7 +/- 2.4%). We conclude that there is no difference in high-intensity intermittent running performance when preceded by an active or passive warm-up when matched for post-warm-up Tc. However, repeated sprinting ability is significantly improved after both active and passive warm-ups compared to no warm-up.

  12. Sleep monitoring of a six-day microcycle in strength and high-intensity training.

    Science.gov (United States)

    Kölling, Sarah; Wiewelhove, Thimo; Raeder, Christian; Endler, Stefan; Ferrauti, Alexander; Meyer, Tim; Kellmann, Michael

    2016-08-01

    This study examined the effect of microcycles in eccentric strength and high-intensity interval training (HIT) on sleep parameters and subjective ratings. Forty-two well-trained athletes (mean age 23.2 ± 2.4 years) were either assigned to the strength (n = 21; mean age 23.6 ± 2.1 years) or HIT (n = 21; mean age 22.8 ± 2.6 years) protocol. Sleep monitoring was conducted with multi-sensor actigraphy (SenseWear Armband™, Bodymedia, Pittsburg, PA, USA) and sleep log for 14 days. After a five-day baseline phase, participants completed either eccentric accented strength or high-intensity interval training for six days, with two training sessions per day. This training phase was divided into two halves (part 1 and 2) for statistical analyses. A three-day post phase concluded the monitoring. The Recovery-Stress Questionnaire for Athletes was applied at baseline, end of part 2, and at the last post-day. Mood ratings were decreased during training, but returned to baseline values afterwards in both groups. Sleep parameters in the strength group remained constant over the entire process. The HIT group showed trends of unfavourable sleep during the training phase (e.g., objective sleep efficiency at part 2: mean = 83.6 ± 7.8%, F3,60 = 2.57, P = 0.06, [Formula: see text] = 0.114) and subjective improvements during the post phase for awakenings (F3,60 = 2.96, P = 0.04, [Formula: see text] = 0.129) and restfulness of sleep (F3,60 = 9.21, P strength training, and sufficient sleep time should be emphasised and monitored.

  13. High intensity exercise or conventional exercise for patients with rheumatoid arthritis?: outcome expectations of patients, rheumatologists, and physiotherapists.

    NARCIS (Netherlands)

    Munneke, M.; Jong, Z. de; Zwinderman, A.H.; Ronday, H.K.; Ende, C.H.M. van den; Vliet Vlieland, T.P.M.; Hazes, J.M.W.

    2004-01-01

    OBJECTIVE: To examine the outcome expectations of RA patients, rheumatologists, and physiotherapists regarding high intensity exercise programmes compared with conventional exercise programmes. METHODS: An exercise outcome expectations questionnaire was administered to 807 RA patients, 153 rheumatol

  14. High Intensity Interval Training in Handcycling : The Effects of a 7 Week Training Intervention in Able-bodied Men

    NARCIS (Netherlands)

    Schoenmakers, Patrick; Reed, Kate; Van Der Woude, Luc; Hettinga, Florentina J.

    2016-01-01

    INTRODUCTION: In lower body endurance training, quantities of both moderate intensity continuous training (MICT) and high intensity interval training (HIIT) can lead to an improved physiological capacity and performance. Limited research is available regarding the endurance and muscular capacity of

  15. Low volume short duration high-intensity interval training and repeated sprint ability in Gaelic football players

    OpenAIRE

    Kelly, David

    2014-01-01

    Gaelic Football is the most popular sport in Ireland and is characterized by irregular changes of pace and high-intensity efforts interspersed with periods of light to moderate intensity activity. Speed, power and aerobic capacity are essential fitness components for optimal performance during match play. A high level of aerobic conditioning is required to generate and maintain power output during repeated high intensity activities. Study 1: Anthropometric, physiological, metabolic and en...

  16. High-protein diet induces oxidative stress in rat brain: protective action of high-intensity exercise against lipid peroxidation

    OpenAIRE

    Camiletti-Moir??n, Daniel; Aparicio Garc??a-Molina, Virginia A.; Nebot Valenzuela, Elena; Medina, Gerardo; Mart??nez, Rosario; Kapravelou, Garyfallia; Andrade, Ana; Porres-Foulquie, Jes??s; L??pez-Jurado, Mar??a; Aranda Ram??rez, Pilar

    2015-01-01

    diets as well as aerobic exercise could promote antioxidant capacity and consequently reduce free radicals overproduction on brain. However, little is know regarding to the high-protein diets and high intensity exercise on oxidative stress production. The aim of this study was to analyse the effects of high-protein diets and high-intensity exercise (HIE) on brain oxidative stress markers. Materials and Methods: A total of 40 male Wistar rats were randomly distributed i...

  17. Acceleration profiles in elite Australian soccer.

    Science.gov (United States)

    Varley, M C; Aughey, R J

    2013-01-01

    We quantified the acceleration and high-velocity running of elite Australian soccer players. We hypothesised that high-intensity activity would be underestimated when excluding acceleration during match analysis given its high metabolic demand and occurrence at low velocities. Player movements were observed from 29 players (forwards and central and wide defenders and midfielders) during domestic Australian competition using 5-Hz global positioning system. Effort occurrence were determined for high-velocity running, sprinting and maximal accelerations. The commencement and final velocity of maximal accelerations were also identified. Players undertook an 8~fold greater number of maximal accelerations than sprints per game (65±21 vs. 8±5). Of maximal accelerations ~98% commenced from a starting velocity lower than what would be considered high-velocity running while ~85% did not cross the high-velocity running threshold. The number of efforts performed in all categories were position dependent (Psprints compared to all other positions (Pdrills.

  18. The different effects of high intensity interval training and moderate intensity interval training for weightlessness countermeasures

    Science.gov (United States)

    Wang, Lin-Jie; Cheng, Tan; Zhi-Li, Li; Hui-juan, Wang; Wen-juan, Chen; Jianfeng, Zhang; Desheng, Wang; Dongbin, Niu; Qi, Zhao; Chengjia, Yang; Yanqing, Wang

    High intensity interval training (HIIT) has been demonstrated to improve performance in a relatively short training period. But the difference between high intensity interval training and moderate intensity interval training (MIIT) in simulated weightlessness still has not been well studied. This study sought to characterize the difference between 6 weeks high intensity interval training and moderate intensity interval training under reduced weight (RW) gait training device and zero-gravity locomotion system (ZLS). Twenty-three subjects (14M/4F, 32.5±4.5 years) volunteered to participate. They were divided into three groups, that were MITT (alternating 2 min at 40% VO _{2} peak and 2 min at 60% VO _{2} peak for 30min, five days per week) RW group (n=8), HITT (alternating 2 min at 40% VO _{2} peak and 2 min at 90% VO _{2} peak for 30min, three days per week) RW group (n=8) and HITT ZLS group (n=7). The Z-axis load used in RW group was 80% body weight (BW) and in ZLS was 100% BW. Cardiopulmonary function was measured before, after 4-week training and after 6-week training. Isokinetic knee extension-flexion test at 60(°) deg/s and 180(°) deg/s were performed before and after the 6-week training, and isometric knee extension-flexion test at 180(°) deg/s was also examined at the same time. It was found that the VO _{2} peaks, metabolic equivalent (MET), Speedmax and respiratory exchange ratio (RER) were significantly increased after 4 and 6-week training in all three groups and no significant group difference were detected. The peak torque at 60(°) deg/s for right knee flexion were significantly increased after 6 week-training in all three groups, and only in HITT RW group the total power at 60(°) deg/s for right knee flexion enhanced. The total power and average power at 60(°) deg/s for right knee extension decreased significantly after 6-week training in all three groups. The peak torque at 60(°) deg/s for right knee extension in MIIT RW group was

  19. Future accelerators (?)

    Energy Technology Data Exchange (ETDEWEB)

    John Womersley

    2003-08-21

    I describe the future accelerator facilities that are currently foreseen for electroweak scale physics, neutrino physics, and nuclear structure. I will explore the physics justification for these machines, and suggest how the case for future accelerators can be made.

  20. Enhancement of Skeletal Muscle in Aged Rats Following High-Intensity Stretch-Shortening Contraction Training.

    Science.gov (United States)

    Rader, Erik P; Naimo, Marshall A; Layner, Kayla N; Triscuit, Alyssa M; Chetlin, Robert D; Ensey, James; Baker, Brent A

    2016-08-03

    Exercise is the most accessible, efficacious, and multifactorial intervention to improve health and treat chronic disease. High-intensity resistance exercise, in particular, also maximizes skeletal muscle size and strength-outcomes crucial at advanced age. However, such training is capable of inducing muscle maladaptation when misapplied at old age. Therefore, characterization of parameters (e.g., mode and frequency) that foster adaptation is an active research area. To address this issue, we utilized a rodent model that allowed training at maximal intensity in terms of muscle activation and tested the hypothesis that muscles of old rats adapt to stretch-shortening contraction (SSC) training, provided the training frequency is sufficiently low. At termination of training, normalized muscle mass (i.e., muscle mass divided by tibia length) and muscle quality (isometric force divided by normalized muscle mass) were determined. For young rats, normalized muscle mass increased by ∼20% regardless of training frequency. No difference was observed for muscle quality values after 2 days versus 3 days per week training (0.65 ± 0.09 N/mg/mm vs. 0.59 ± 0.05 N/mg/mm, respectively). For old rats following 3 days per week training, normalized muscle mass was unaltered and muscle quality was 30% lower than young levels. Following 2 days per week training at old age, normalized muscle mass increased by 17% and muscle quality was restored to young levels. To investigate this enhanced response, oxidative stress was assessed by lipid peroxidation quantification. For young rats, lipid peroxidation levels were unaltered by training. With aging, baseline levels of lipid peroxidation increased by 1.5-fold. For old rats, only 2 days per week training decreased lipid peroxidation to levels indistinguishable from young values. These results imply that, appropriately scheduled high-intensity SSC training at old age is capable of restoring muscle to a younger phenotype in terms

  1. Cordyceps militaris Improves Tolerance to High-Intensity Exercise After Acute and Chronic Supplementation.

    Science.gov (United States)

    Hirsch, Katie R; Smith-Ryan, Abbie E; Roelofs, Erica J; Trexler, Eric T; Mock, Meredith G

    2016-07-13

    To determine the effects of a mushroom blend containing Cordyceps militaris on high-intensity exercise after 1 and 3 weeks of supplementation. Twenty-eight individuals (Mean ± standard deviation [SD]; Age = 22.7 ± 4.1 yrs; Height = 175.4 ± 8.7 cm; Weight = 71.6 ± 12.0 kg) participated in this randomized, repeated measures, double-blind, placebo-controlled design. Maximal oxygen consumption (VO2max), time to exhaustion (TTE), and ventilatory threshold (VT) were measured during a maximal graded exercise test on a cycle ergometer. Relative peak power output (RPP), average power output (AvgP), and percent drop (%drop) were recorded during a 3 minute maximal cycle test with resistance at 4.5% body weight. Subjects consumed 4 g·d(-1) mushroom blend (MR) or maltodextrin (PL) for 1 week. Ten volunteers supplemented for an additional 2 weeks. Exercise tests were separated by at least 48 hours and repeated following supplementation periods. One week of supplementation elicited no significant time × treatment interaction for VO2max (p = 0.364), VT (p = 0.514), TTE (p = 0.540), RPP (p = 0.134), AvgP (p = 0.398), or %drop (p = 0.823). After 3 weeks, VO2max significantly improved (p = 0.042) in MR (+4.8 ml·kg(-1)·min(-1)), but not PL (+0.9 ml·kg(-1)·min(-1)). Analysis of 95% confidence intervals revealed significant improvements in TTE after 1- (+28.1 s) and 3 weeks (+69.8 s) in MR, but not PL, with additional improvements in VO2max (+4.8 ml·kg(-1)·min(-1)) and VT (+0.7 l·min(-1)) after 3 weeks. Acute supplementation with a Cordyceps militaris containing mushroom blend may improve tolerance to high-intensity exercise; greater benefits may be elicited with consistent chronic supplementation.

  2. Improving fitness of elite handball players: small-sided games vs. high-intensity intermittent training.

    Science.gov (United States)

    Iacono, Antonio Dello; Eliakim, Alon; Meckel, Yoav

    2015-03-01

    The present study was designed to compare the effects of high-intensity intermittent training (HIIT) and small-sided games (SSGs) training on fitness variables of elite handball players. Eighteen highly trained players (mean age ± SD: 25.6 ± 0.5 years) were assigned to either HIIT or SSGs group training protocols twice per week for 8 weeks. The HIIT consisted of 12-24 × 15 seconds of high-intensity runs interspersed by 15 seconds of recovery. The SSGs training consisted of 3 against 3 small-sided handball games. Both training methods were matched for exercise duration and recovery at each training session. Before and after 8-week training, the following fitness variables were assessed-speed: 10- and 20-m sprint time, agility: handball agility specific test (HAST), upper arm strength: 1 repetition maximum (1RM) bench press test, lower limb power: counter-movement jump tests with (CMJarm) and without (CMJ) arm movement, and aerobic fitness (yo-yo intermittent recovery test level 1 [YYIRTL1]). Significant improvement was found in the YYIRTL1 (23.3 and 26.3%, respectively), 10-m sprint (2.3 and 4.1%, respectively) and 20-m sprint (2.1 and 4%, respectively), HAST (1.1 and 2.2%, respectively), 1RM bench press (6.8 and 12.3%, respectively), CMJ (7.4 and 10.8%, respectively), and CMJarm (6.4 and 8.9%, respectively) following training in both groups (p ≤ 0.05 for all). There was a significantly greater improvement in 10- and 20-m sprint, HAST, 1RM, CMJ, and CMJarm following the SSGs training compared with the HIIT (p ≤ 0.05 for all). These results indicated that both HIIT and SSGs are effective training methods for fitness development among elite adult handball players. However, SSGs training may be considered as the preferred training regimen for improving handball-specific fitness variables during the in-season period.

  3. Tolerance to high-intensity intermittent running exercise: do oxygen uptake kinetics really matter?

    Directory of Open Access Journals (Sweden)

    Martin eBuchheit

    2012-10-01

    Full Text Available We examined the respective associations between aerobic fitness (VO2max, metabolic control (VO2 kinetics and locomotor function and various physiological responses to high-intensity intermittent running exercise (HIT in team sport players. Eleven players (30.5 ± 3.6 y performed a series of tests to determine their VO2max and the associated velocity (vVO2max, maximal sprinting speed (MSS and VO2 kinetics at exercise onset in the moderate and severe intensity domains, and during recovery (VO2τoff SEV. Cardiorespiratory variables, oxygenation and electromyography (EMG of lower limbs muscles and blood lactate concentration ([La] were collected during a standardized HIT protocol consisting in 8 sets of 10, 4-s runs. During HIT, four players could not complete more than 2 sets; the others finished at least 5 sets. Metabolic responses to the 2 first sets of HIT were negatively correlated with VO2max, vVO2max, and VO2τoff SEV (r=-0.6 to -0.8, while there was no clear relationship with the other variables. VO2, oxygenation and [La] responses to the first 2 sets of HIT were the only variables that differed between the players which could complete at least 5 sets or those who could not complete more than 2 sets. Players that managed to run at least 5 sets presented, in comparison with the others, greater v O2max (ES=+1.5(0.4;2.7, MSS(ES=+1.0(0.1;1.9 and training load (ES=+3.8 (2.8;4.9. There was no clear between-group difference in any of the VO2 kinetics measures (e.g., ES=-0.1(-1.4;1.2 for VO2τon SEV. While VO2max and vVO2max are likely determinant for HIT tolerance, the importance of VO2 kinetics as assessed in the present study appears limited in the present population. Knowing the main factors influencing tolerance to high-intensity intermittent running exercise may assist practitioners in personalizing training interventions.

  4. Quadriceps and respiratory muscle fatigue following high-intensity cycling in COPD patients.

    Directory of Open Access Journals (Sweden)

    Damien Bachasson

    Full Text Available Exercise intolerance in COPD seems to combine abnormal ventilatory mechanics, impaired O2 transport and skeletal muscle dysfunction. However their relative contribution and their influence on symptoms reported by patients remain to be clarified. In order to clarify the complex interaction between ventilatory and neuromuscular exercise limiting factors and symptoms, we evaluated respiratory muscles and quadriceps contractile fatigue, dynamic hyperinflation and symptoms induced by exhaustive high-intensity cycling in COPD patients. Fifteen gold II-III COPD patients (age = 67 ± 6 yr; BMI = 26.6 ± 4.2 kg.m(-2 performed constant-load cycling test at 80% of their peak workload until exhaustion (9.3 ± 2.4 min. Before exercise and at exhaustion, potentiated twitch quadriceps strength (Q(tw, transdiaphragmatic (P(di,tw and gastric (P(ga,tw pressures were evoked by femoral nerve, cervical and thoracic magnetic stimulation, respectively. Changes in operational lung volumes during exercise were assessed via repetitive inspiratory capacity (IC measurements. Dyspnoea and leg discomfort were measured on visual analog scale. At exhaustion, Q(tw (-33 ± 15%, >15% reduction observed in all patients but two and Pdi,tw (-20 ± 15%, >15% reduction in 6 patients were significantly reduced (P15% reduction in 3 patients. Percentage reduction in Q(tw correlated with the percentage reduction in P(di,tw (r = 0.66; P<0.05. Percentage reductions in P(di,tw and P(ga,tw negatively correlated with the reduction in IC at exhaustion (r = -0.56 and r = -0.62, respectively; P<0.05. Neither dyspnea nor leg discomfort correlated with the amount of muscle fatigue. In conclusion, high-intensity exercise induces quadriceps, diaphragm and less frequently abdominal contractile fatigue in this group of COPD patients. In addition, the rise in end-expiratory lung volume and diaphragm flattening associated with dynamic hyperinflation in COPD might limit the development of abdominal and

  5. Effect of high-intensity training on endothelial function in patients with cardiovascular and cerebrovascular disease: A systematic review

    Directory of Open Access Journals (Sweden)

    Mia Kolmos

    2016-12-01

    Full Text Available Objectives: Exercise improves endothelial dysfunction, the key manifestation of cardiovascular and cerebrovascular disease, and is recommended in both cardiovascular and cerebrovascular rehabilitation. Disagreement remains, however, on the role of intensity of exercise. The purpose of this review was to gather current knowledge on the effects of high-intensity training versus moderate-intensity continuous exercise on endothelial function in cardiovascular and cerebrovascular patients. Methods: A systematic review was performed in PubMed database, Embase and Cochrane libraries and on PEDro using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies were restricted to cardiovascular and cerebrovascular patients, and healthy subjects as general reference. Interventions comprised of high-intensity training alone, high-intensity training compared to moderate-intensity continuous exercise, or no training, with endothelial function as outcome measure. Endothelial function was measured either physiologically by flow-mediated dilatation and/or by systemic biomarkers. Data were analyzed descriptively due to non-comparability for a meta-analysis to be performed. Results: A total of 20 studies were included in the review. Although there was great heterogenecity in design, population and exercise protocols, all studies found high-intensity training to be safe. High-intensity training was equal to moderate-intensity continuous exercise through improvement in endothelial function in 15 of the 20 selected studies, as measured by flow-mediated dilatation, nitric oxide bioavailability and circulating biomarkers. Only a few studies examined high-intensity training in cerebrovascular patients, none with endothelial function as outcome. Conclusion: High-intensity training is promising as a time-efficient exercise strategy in cardiovascular rehabilitation, but data on endothelial effects in cerebrovascular rehabilitation are

  6. High intensity uranium beams from the superHILAC and the bevatron: final report

    Energy Technology Data Exchange (ETDEWEB)

    1982-03-01

    The two injectors formerly used at the SuperHILAC were a 750-kV air-insulated Cockcroft-Walton (EVE) and a 2.5-MV pressurized HV multiplier (ADAM). The EVE injector can deliver adequate intensities of ions up to mass 40 (argon). The ADAM injector can accelerate ions with lower charge-to-mass ratios, and they can produce beams of heavier ions. The intensity of these beams decreases as the mass number increases, with the lowest practical intensity being achieved with lead beams. Experience with the two existing injectors provided substantial help in defining the general requirements for a new injector which would provide ample beams above mass 40. The requirements for acceptance by the first tank of the SuperHILAC are a particle velocity ..beta.. = 0.0154 (corresponding to an energy of 113 keV/amu) and a charge-to-mass ratio of 0.046 or larger. Present ion source performance dictates an air-insulated Cockcroft-Walton as a pre-accelerator because of its easy accessibility and its good overall reliability. The low charge state ions then receive further acceleration and, if necessary, subsequent stripping to the required charge state before injection into the SuperHILAC. A low-beta linac of the Widereoe type has been built to perform this acceleration. The injector system described consists of a Cockcroft-Walton pre-injector, injection beam lines and isotope analysis, a low-velocity linear accelerator, and SuperHILAC control center modifications.

  7. Deflection of high-intensity pulsed ion beam in focusing magnetically insulated ion diode with a passive anode

    Science.gov (United States)

    Zhu, X. P.; Zhang, Q.; Ding, L.; Zhang, Z. C.; Yu, N.; Pushkarev, A.; Lei, M. K.

    2016-12-01

    The focused high-intensity pulsed ion beam (HIPIB) of 100 ns order pulse is generated with respect to its spatial stability in two types of magnetically insulated ion diodes (MIDs) with geometrical focusing configuration using the passive anode, i.e., insulation of electrons with an external magnetic-field and a self-magnetic field, respectively. Anode plasma formation for the ion beam generation is based on different processes in the two types of MIDs, as the surface breakdown on the polymer-coated anode operated in the unipolar pulse mode for the external-magnetic field MID and the explosive electron emission on the graphite anode in the bipolar-pulse mode for the self-magnetic field MID. Typical energy density per pulse is in the range of 3-6 J/cm2, at an accelerating voltage of 200-300 kV with a pulse duration of 120-150 ns. The spatial deviations of the HIPIB is evaluated by measuring the energy density distribution by using an infrared diagnostic method considering neutralizing during the ion beam propagation to the focal plane with a spatial resolution of 1 mm. The ion beam deviation is about ±1.5 mm for the external-magnetic field MID and ±2.5 mm for the self-magnetic field MID, leading to a fluctuation in the energy density of 1%-12%, and 9%-27% within a 10 mm range at the focal point, respectively. It is revealed that the displacement of different parts of a beam spot occurs nonsynchronously, mainly attributable to the intrinsic diode processes of plasma generation and expansion, and ion beam extraction from the anode-cathode gap, while the influence of magnetic field in the transportation region is negligible. The ion beam spatial deviation has a major influence on the shot-to-shot stability of ion beam, and it is suggested that the stability can be enhanced via diode process improvement.

  8. High-Intensity Focused Ultrasound for Prostate Cancer: Long-Term Followup and Complications Rate

    Directory of Open Access Journals (Sweden)

    Umberto Maestroni

    2012-01-01

    Full Text Available Introduction. As it is well known, High Intensity Focused Ultrasound (HIFU is a minimally invasive procedure for prostate cancer. Many investigators reported their series of patients, demonstrating the effectiveness of the treatment. The most majority of Authors, however, do not report the side effects and the complications of the procedure, which is the aim of our study. The diagnosis and management of complications is discussed, and the oncologic outcome is reported in terms of quality of life. Materials and Methods. We report our experience in 89 patients, low-, intermediate-, and high-risk patients according with D’Amico classification. All data collected along the study were analyzed, including side effects and complications of the procedure. Results. Our series demonstrates the effectiveness of the procedure, in line with larger series reported in literature by other investigators. The most important side effects are sexual function impairment and transient incontinence in a minority of cases. Minor complications are reported as well as rare cases of major complications, which can require surgical treatment.

  9. Reliability of telemetric electromyography and near-infrared spectroscopy during high-intensity resistance exercise.

    Science.gov (United States)

    Scott, Brendan R; Slattery, Katie M; Sculley, Dean V; Lockie, Robert G; Dascombe, Ben J

    2014-10-01

    This study quantified the inter- and intra-test reliability of telemetric surface electromyography (EMG) and near infrared spectroscopy (NIRS) during resistance exercise. Twelve well-trained young men performed high-intensity back squat exercise (12 sets at 70-90% 1-repetition maximum) on two occasions, during which EMG and NIRS continuously monitored muscle activation and oxygenation of the thigh muscles. Intra-test reliability for EMG and NIRS variables was generally higher than inter-test reliability. EMG median frequency variables were generally more reliable than amplitude-based variables. The reliability of EMG measures was not related to the intensity or number of repetitions performed during the set. No notable differences were evident in the reliability of EMG between different agonist muscles. NIRS-derived measures of oxyhaemoglobin, deoxyhaemoglobin and tissue saturation index were generally more reliable during single-repetition sets than multiple-repetition sets at the same intensity. Tissue saturation index was the most reliable NIRS variable. Although the reliability of the EMG and NIRS measures varied across the exercise protocol, the precise causes of this variability are not yet understood. However, it is likely that biological variation during multi-joint isotonic resistance exercise may account for some of the variation in the observed results.

  10. Using passive cavitation images to classify high-intensity focused ultrasound lesions.

    Science.gov (United States)

    Haworth, Kevin J; Salgaonkar, Vasant A; Corregan, Nicholas M; Holland, Christy K; Mast, T Douglas

    2015-09-01

    Passive cavitation imaging provides spatially resolved monitoring of cavitation emissions. However, the diffraction limit of a linear imaging array results in relatively poor range resolution. Poor range resolution has limited prior analyses of the spatial specificity and sensitivity of passive cavitation imaging in predicting thermal lesion formation. In this study, this limitation is overcome by orienting a linear array orthogonal to the high-intensity focused ultrasound propagation direction and performing passive imaging. Fourteen lesions were formed in ex vivo bovine liver samples as a result of 1.1-MHz continuous-wave ultrasound exposure. The lesions were classified as focal, "tadpole" or pre-focal based on their shape and location. Passive cavitation images were beamformed from emissions at the fundamental, harmonic, ultraharmonic and inharmonic frequencies with an established algorithm. Using the area under a receiver operating characteristic curve (AUROC), fundamental, harmonic and ultraharmonic emissions were found to be significant predictors of lesion formation for all lesion types. For both harmonic and ultraharmonic emissions, pre-focal lesions were classified most successfully (AUROC values of 0.87 and 0.88, respectively), followed by tadpole lesions (AUROC values of 0.77 and 0.64, respectively) and focal lesions (AUROC values of 0.65 and 0.60, respectively).

  11. In vivo hyperthermia effect induced by high-intensity pulsed ultrasound

    Institute of Scientific and Technical Information of China (English)

    Cui Wei-Cheng; Tu Juan; Hwang Joo-Ha; Li Qian; Fan Ting-Bo; Zhang Dong; Chen Jing-Hai; Chen Wei-Zhong

    2012-01-01

    Hyperthermia effects (39-44 ℃) induced by pulsed high-intensity focused ultrasound (HIFU) have been regarded as a promising therapeutic tool for boosting immune responses or enhancing drug delivery into a solid tumor.However,previous studies also reported that the cell death occurs when cells are maintained at 43 ℃ for more than 20 minutes.The aim of this study is to investigate thermal responses inside in vivo rabbit auricular veins exposed to pulsed HIFU (1.17 MHz,5300 W/cm2,with relatively low-duty ratios (0.2%-4.3%).The results show that:(1) with constant pulse repetition frequency (PRF) (e.g.,1 Hz),the thermal responses inside the vessel will increase with the increasing duty ratio; (2) a temperature elevation to 43 ℃ can be identified at the duty ratio of 4.3%; (3) with constant duty ratios,the change of PRF will not significantly affect the temperature measurement in the vessel; (4) as the duty ratios lower than 4.3%,the presence of microbubbles will not significantly enhance the thermal responses in the vessel,but will facilitate HIFU-induced inertial cavitation events.

  12. Discrete vortex model of a Helmholtz resonator subjected to high-intensity sound and grazing flow.

    Science.gov (United States)

    Dai, Xiwen; Jing, Xiaodong; Sun, Xiaofeng

    2012-11-01

    In this paper, a theoretical model is developed to study the acoustical response of a Helmholtz resonator as a duct-branched acoustic absorber subjected to both high-intensity sound and grazing flow. The present model is comprised of a discrete vortex model in combination with a one-dimensional duct sound propagation model. The present work is to study the overall effect of incident sound interacting with grazing flow but putting emphasis on the nonlinear or intermediate regime where the sound intensity has a marked or non-negligible influence on the acoustic behavior of the Helmholtz resonator. The numerical results reveal that the flow field around the orifice is dominated by the evolution of the vortex sheet and the flow pattern is influenced by the ratio of the orifice flow velocity to the grazing flow velocity. When the incident sound pressure is high or the resonance occurs, the resonator shows nonlinearity, i.e., the acoustic impedance and absorption coefficient vary not only with duct flow Mach number buy also with incident frequency and incident sound pressure level.

  13. Effects of 12 weeks high-intensity & reduced-volume training in elite athletes

    DEFF Research Database (Denmark)

    Kilen, Anders; Larsson, Tanja Hultengren; Jørgensen, Majke

    2014-01-01

    It was investigated if high-intensity interval training (HIT) at the expense of total training volume improves performance, maximal oxygen uptake and swimming economy. 41 elite swimmers were randomly allocated to a control (CON) or HIT group. For 12 weeks both groups trained ∼12 h per week. HIT...... (60.4±4.0 vs. 60.3±4.0 s; n = 13 and 133.2±6.4 vs. 132.6±7.7 s; n = 14) and CON (60.2±3.7 vs. 60.6±3.8 s; n = 15 and 133.5±7.0 vs. 133.3±7.6 s; n = 15). Maximal oxygen uptake during swimming was similar before and after the intervention in both the HIT (4.0±0.9 vs. 3.8±1.0 l O2×min-1; n = 14) and CON...

  14. Nonlinear 3-D simulation of high-intensity focused ultrasound therapy in the kidney

    CERN Document Server

    Suomi, Visa; Treeby, Bradley; Cleveland, Robin

    2016-01-01

    Kidney cancer is a severe disease which can be treated non-invasively using high-intensity focused ultrasound (HIFU) therapy. However, tissue in front of the transducer and the deep location of kidney can cause significant losses to the efficiency of the treatment. The effect of attenuation, refraction and reflection due to different tissue types on HIFU therapy of the kidney was studied using a nonlinear ultrasound simulation model. The geometry of the tissue was derived from a computed tomography (CT) dataset of a patient which had been segmented for water, bone, soft tissue, fat and kidney. The combined effect of inhomogeneous attenuation and sound-speed was found to result in an 11.0 dB drop in spatial peak-temporal average (SPTA) intensity in the kidney compared to pure water. The simulation without refraction effects showed a 6.3 dB decrease indicating that both attenuation and refraction contribute to the loss in focal intensity. The losses due to reflections at soft tissue interfaces were less than 0....

  15. Intial characterization fo a commerical electron gun for profiling high intensity proton beams in Project X

    Energy Technology Data Exchange (ETDEWEB)

    Thurman-Keup, R.; Johnson, A.S.; Lumpkin, A.H.; Thangaraj, J.C.T.; Zhang, D.; /Fermilab; Blokland, W.; /Oak Ridge

    2011-03-01

    Measuring the profile of a high-intensity proton beam is problematic in that traditional invasive techniques such as flying wires don't survive the encounter with the beam. One alternative is the use of an electron beam as a probe of the charge distribution in the proton beam as was done at the Spallation Neutron Source at ORNL. Here we present an initial characterization of the beam from a commercial electron gun from Kimball Physics, intended for use in the Fermilab Main Injector for Project X. Despite the fact that the horizontal spot size is abnormally large in the high current measurement, the spot size at the downstream cross X2 is reasonable in the context of measuring the deflection. A thin foil OTR would help with the beam heating and should be tried. The next phase of this experiment is to simulate the proton beam with a pair of current carrying wires and to design and construct a fast deflector. Some of the remaining issues to be considered include determining the minimum beam current needed to observe the deflected beam for a given sweep time and the impact of longitudinal variations in the charge density of the bunch.

  16. High intensity magnetic separation for the clean-up of a site polluted by lead metallurgy.

    Science.gov (United States)

    Sierra, C; Martínez, J; Menéndez-Aguado, J M; Afif, E; Gallego, J R

    2013-03-15

    The industrial history in the district of Linares (Spain) has had a severe impact on soil quality. Here we examined soil contaminated by lead and other heavy metals in "La Cruz" site, a brownfield affected by metallurgical residues. Initially, the presence of contaminants mainly associated with the presence of lead slag fragments mixed with the soil was evaluated. The subsequent analysis showed a quasi-uniform distribution of the pollution irrespective of the grain-size fractions. This study was accompanied by a characterization of the lead slag behavior under the presence of a magnetic field. Two main magnetic components were detected: first a ferromagnetic and/or ferrimagnetic contribution, second a paramagnetic and/or antiferromagnetic one. It was also established that the slag was composed mainly of lead spherules and iron oxides embedded in a silicate matrix. Under these conditions, the capacity of magnetic separation to remove pollutants was examined. Therefore, two high intensity magnetic separators (dry and wet devices, respectively) were used. Dry separation proved to be successful at decontaminating soil in the first stages of a soil washing plant. In contrast, wet separation was found effective as a post-process for the finer fractions.

  17. Improved heating efficiency with High-Intensity Focused Ultrasound using a new ultrasound source excitation.

    Science.gov (United States)

    Bigelow, Timothy A

    2009-01-01

    High-Intensity Focused Ultrasound (HIFU) is quickly becoming one of the best methods to thermally ablate tissue noninvasively. Unlike RF or Laser ablation, the tissue can be destroyed without inserting any probes into the body minimizing the risk of secondary complications such as infections. In this study, the heating efficiency of HIFU sources is improved by altering the excitation of the ultrasound source to take advantage of nonlinear propagation. For ultrasound, the phase velocity of the ultrasound wave depends on the amplitude of the wave resulting in the generation of higher harmonics. These higher harmonics are more efficiently converted into heat in the body due to the frequency dependence of the ultrasound absorption in tissue. In our study, the generation of the higher harmonics by nonlinear propagation is enhanced by transmitting an ultrasound wave with both the fundamental and a higher harmonic component included. Computer simulations demonstrated up to a 300% increase in temperature increase compared to transmitting at only the fundamental for the same acoustic power transmitted by the source.

  18. Effects of autonomous motivational priming on motivation and affective responses towards high-intensity interval training.

    Science.gov (United States)

    Brown, Denver M Y; Teseo, Amanda J; Bray, Steven R

    2016-08-01

    This study examined the effect of autonomous motivational priming on motivation, attitudes and intentions towards high-intensity interval training (HIT). Participants (N = 42) performed a graded exercise test to determine their peak aerobic power (WPEAK). At a subsequent testing session, participants were randomised to complete either an autonomous or neutral motivational priming task followed by a 10 × 1 HIT exercise protocol, alternating 1-min bouts of hard (70% WPEAK) and light (12.5% WPEAK) exercises for 20 min. Participants primed with autonomous motivation reported greater enjoyment, P = .009, ηp(2) = .16, and perceived competence, P = .005, ηp(2) = .18, post-exercise compared to those in the neutral priming condition. Participants in the autonomous motivational priming condition also reported more positive attitudes, P = .014, ηp(2) = .14, towards HIT; however, there was no difference between the conditions for task motivation during HIT or intentions, P = .53, ηp(2) = .01, to engage in HIT. These findings highlight autonomous motivational priming as a method of enhancing affective and motivational experiences regarding HIT.

  19. Controlled tissue emulsification produced by high intensity focused ultrasound shock waves and millisecond boiling.

    Science.gov (United States)

    Khokhlova, Tatiana D; Canney, Michael S; Khokhlova, Vera A; Sapozhnikov, Oleg A; Crum, Lawrence A; Bailey, Michael R

    2011-11-01

    In high intensity focused ultrasound (HIFU) applications, tissue may be thermally necrosed by heating, emulsified by cavitation, or, as was recently discovered, emulsified using repetitive millisecond boiling caused by shock wave heating. Here, this last approach was further investigated. Experiments were performed in transparent gels and ex vivo bovine heart tissue using 1, 2, and 3 MHz focused transducers and different pulsing schemes in which the pressure, duty factor, and pulse duration were varied. A previously developed derating procedure to determine in situ shock amplitudes and the time-to-boil was refined. Treatments were monitored using B-mode ultrasound. Both inertial cavitation and boiling were observed during exposures, but emulsification occurred only when shocks and boiling were present. Emulsified lesions without thermal denaturation were produced with shock amplitudes sufficient to induce boiling in less than 20 ms, duty factors of less than 0.02, and pulse lengths shorter than 30 ms. Higher duty factors or longer pulses produced varying degrees of thermal denaturation combined with mechanical emulsification. Larger lesions were obtained using lower ultrasound frequencies. The results show that shock wave heating and millisecond boiling is an effective and reliable way to emulsify tissue while monitoring the treatment with ultrasound.

  20. Heightened serotonin influences contest outcome and enhances expression of high-intensity aggressive behaviors.

    Science.gov (United States)

    Bubak, Andrew N; Renner, Kenneth J; Swallow, John G

    2014-02-01

    The outcome of behavioral interactions between organisms can have significant fitness implications. Therefore, it is of great theoretical and practical importance to understand the mechanisms that modify different agonistic behaviors. Changes in central monoamines, such as serotonin (5-HT), contribute to modifying the expression of aggressive encounters in both vertebrates and invertebrates. In several invertebrate groups, neural 5-HT has been linked to heightened aggression and conflict escalation. The male stalk-eyed fly (Teleopsis dalmanni) competes with conspecifics daily over access to resources such as food and mates. Because encounters escalate in a stereotypical manner, stalk-eyed flies provide an excellent model system to study behavioral syndromes. We hypothesized that noninvasive, pharmacological augmentation of brain 5-HT by administration of the precursor, 5-hydroxytryptophan (5-HTP), would increase stereotypic behavioral escalation and the probability of winning a conflict over food. Size-matched male 5-HTP-treated and untreated flies were placed in a forced-fight paradigm and their aggressive behaviors scored. Individuals with higher brain 5-HT levels had a markedly higher probability of winning the contests, displayed greater levels of high-intensity aggressive behaviors and fewer retreats. Pretreatment with 5-HTP did not significantly alter octopamine or tyramine, suggesting that central 5-HT may modulate aggression in these organisms and play a role in determining reproductive success and resource attainment.

  1. Finite element modeling of heating phenomena of cracks excited by high-intensity ultrasonic pulses

    Institute of Scientific and Technical Information of China (English)

    Chen Zhao-Jiang; Zheng Jiang; Zhang Shu-Yi; Mi Xiao-Bing; Zheng Kai

    2010-01-01

    A three-dimensional thermo-mechanical coupled finite element model is built up to simulate the phenomena of dynamical contact and frictional heating of crack faces when the plate containing the crack is excited by high-intensity ultrasonic pulses. In the finite element model, the high-power ultrasonic transducer is modeled by using a piezoelectric thermal-analogy method, and the dynamical interaction between both crack faces is modeled using a contact-impact theory. In the simulations, the frictional heating taking place at the crack faces is quantitatively calculated by using finite element thermal-structural coupling analysis, especially, the influences of acoustic chaos to plate vibration and crack heating are calculated and analysed in detail Meanwhile, the related ultrasonic infrared images are also obtained experimentally, and the theoretical simulation results are in agreement with that of the experiments. The results show that, by using the theoretical method, a good simulation of dynamic interaction and friction heating process of the crack faces under non-chaotic or chaotic sound excitation can be obtained.

  2. High-Intensity Focused Ultrasound (Hifu) Treatment For Thyroid Nodules: Experimental And First Clinical Studies

    Science.gov (United States)

    Esnault, Olivier; Franc, Brigitte; Leenhardt, Laurence; Rouxel, Agnès; Ménégaux, Fabrice; Lacoste, François

    2007-05-01

    OBJECTIVE: Thyroid nodules are common and can only be removed by surgery. High-intensity focused ultrasound (HIFU) could be a possible minimally invasive alternative treatment. The aim of this study was to assess the feasibility of using HIFU to precisely ablate thyroid nodules without affecting neighbouring structures. METHODS: HIFU was generated by a 3-MHz spherical piezocomposite transducer moved across the target in a stepwise fashion. In a first clinical study 25 patients had their nodules treated with HIFU 2 weeks prior to planned thyroidectomy, using increasing energy. The last patients received a local anesthesia. The lesions were assessed by the pathologist. RESULTS: The histological lesions were clearly visible in most of the fully treated patients, particularly those who received higher energy. Superficial and reversible skin blisters were observed in 7 patients. The design of the treatment head was subsequently modified to eliminate such risk. CONCLUSION: The patient trials confirmed the precision of the targeting and set the energy levels for safe thyroid nodule ablation with HIFU. Further study is needed to assess nodule's changes at longer follow-up.

  3. Localized Ablation of Thyroid Tissue by High-Intensity Focused Ultrasound: an Alternative to Surgery?

    Science.gov (United States)

    Esnault, Olivier; Franc, Brigitte; Chapelon, Jean-Yves; Lacoste, Francois

    2006-05-01

    PURPOSE: The aim of this study was to evaluate the feasibility of using a High-intensity focused ultrasound (HIFU) device to obtain a localised destruction of the thyroid with no damage to adjacent tissues. MATERIALS AND METHODS: The ewe model was used because its thyroid gland is easily accessible with ultrasound. The animals were anaesthetised with 10 mg / kg IV injection of Penthothal. The HIFU pulses were generated by a 3-MHz spherical transducer under ultrasound guidance. Macroscopic and microscopic tissue lesions were identified after formalin fixation of the anterior part of the ewe's neck. RESULTS: After determining the optimal instrument settings to obtain localized thyroid ablation, the repeatability of the method was evaluated using a HIFU prototype designed specifically for human use: in 13 ewes (26 treated lobes), an average of 20 (range: 14-27) ultrasound pulses (pulse duration: 3 s) per lobe covering a mean volume of 0.5 cm3 (range: 0.3-0.7 cm3) were delivered. The ewes were sacrificed 2-5 weeks after treatment delivery. No damage to the nerves, trachea, esophagus or muscle was observed. Only 3 ewes suffered superficial skin burns. The desired thyroid lesions were obtained in 25/26 treated lobes, as demonstrated by fibrotic tissues, which replaced necrotic areas. CONCLUSION: These results obtained in the ewe model show that thyroid lesions of defined volume can be induced safely and suggest that the HIFU device is now ready for human trials.

  4. The Blood Lactate Increase in High Intensity Exercise Is Depressed by Acanthopanax sieboldianus

    Directory of Open Access Journals (Sweden)

    Hyukki Chang

    2013-10-01

    Full Text Available This study investigates the anti-fatigue effects of Acanthopanax sieboldianus (A. sieboldianus at various exercise intensities. Two experiments were conducted in 18 Sprague-Dawley rats. In Experiment 1, a three-stage increment test (15 m/min for 5 min, and 20 m/min for 5 min and 25 m/min for 10 min was performed using a treadmill. In Experiment 2, a 10-min swimming test was conducted. Blood samples were extracted from each rat before, during and after the exercises and the blood concentrations of lactate and glucose measured. In both experiments, water (control or A. sieboldianus solution (ASS was administered orally using a zonde 30 min before the exercise. In the swimming test, ASS administration significantly decreased the blood lactate level measured at the end of the exercise and 5 min post-exercise relative to the water group, although the two groups did not differ significantly in the treadmill test. Our study demonstrates that a single oral administration of A. sieboldianus prior to high-intensity exercise significantly decreases the blood lactate concentration suggesting that A. sieboldianus has an intrinsic anti-fatigue effect.

  5. High-intensity femtosecond laser absorption by rare-gas clusters

    Institute of Scientific and Technical Information of China (English)

    李邵辉; 王成; 刘建胜; 王向欣; 朱频频; 李儒新; 倪国权; 徐至展

    2003-01-01

    The energy absorption efficiency of high-intensity (~ 1016W/cm2) femtosecond laser pulses in a dense jet of large rare-gas clusters has been measured. Experimental results show that the energy absorption efficiency is strongly dependent on the cluster size and can be higher than 90%. The measurement of the ion energy indicates that the average ion energies of argon and xenon can be as high as 90 and 100keV, respectively. The dependence of the average energy of the ions on the cluster size is also measured. At comparatively low gas backing pressure, the average ion energies of argon and xenon increase with increasing gas backing pressure. The average ion energy of argon becomes saturated gradually with further increase of the gas backing pressure. For xenon, the average ion energy drops a little after the gas backing pressure exceeds 9 bar (3.2×105 atoms/cluster). The result showing the existence of a maximum average ion energy has been interpreted within the framework of the microplasma sphere model.

  6. High-intensity tasks with external load in military applications: a review.

    Science.gov (United States)

    O'Neal, Eric K; Hornsby, Jared H; Kelleran, Kyle J

    2014-09-01

    This article provides a synopsis of the limited investigations examining the impact of external load (EL) on performance of high-intensity tasks under load (HITL), EL training intervention effects on HITL performance, and injuries from EL training. Repetitive lifting tasks and initiation of locomotion, such as rapidly moving from a prone position to sprinting appear to be more hindered by EL than maximal sprinting velocity and may explain why training with EL does not improve obstacle course or prolonged (200-300 yard shuttle) drills. EL training appears to offer very little if any benefit for HITL in lesser trained populations. This contrast results of multiple studies incorporating ≥ 3 weeks of prolonged hypergravity interventions (wearing EL during daily activities) in elite anaerobic athletes, indicating EL training stimulus is likely only beneficial to well-trained soldiers. Women and lesser trained individuals appear to be more susceptible to increased injury with EL training. A significant limitation concerning current HITL knowledge is the lack of studies incorporating trained soldiers. Future investigations concerning the effects of HITL on marksmanship, repetitive lifting biomechanics, efficacy of hypergravity training for military personnel, and kinematics of sprinting from tactical positions with various EL displacements and technique training are warranted.

  7. Electrophysiological Changes Correlated with Temperature Increases Induced by High-Intensity Focused Ultrasound Ablation

    Science.gov (United States)

    Wu, Z.; Kumon, R. E.; Laughner, J. I.; Efimov, I. R.; Deng, C. X.

    2014-01-01

    To gain better understanding of the detailed mechanisms of high-intensity focused ultrasound (HIFU) ablation for cardiac arrhythmias, we investigated how the cellular electrophysiological (EP) changes were correlated with temperature increases and thermal dose (cumulative equivalent minutes [CEM43]) during HIFU application using Langendorff-perfused rabbit hearts. Employing voltage-sensitive dye di-4-ANEPPS, we measured the EP and temperature during HIFU using simultaneous optical mapping and infrared imaging. Both action potential amplitude (APA) and AP duration at 50% repolarization (APD50) decreased with temperature increases, and APD50 was more thermally sensitive than APA. EP and tissue changes were irreversible when HIFU-induced temperature increased above 52.3 ± 1.4 °C and log10(CEM43) above 2.16 ± 0.51 (n = 5), but were reversible when temperature was below 50.1 ± 0.8 °C and log10(CEM43) below −0.9 ± 0.3 (n = 9). EP and temperature/thermal dose changes were spatially correlated with HIFU induced tissue necrosis surrounded by a transition zone. PMID:25516446

  8. Improvement of high-voltage staircase drive circuit waveform for high-intensity therapeutic ultrasound

    Science.gov (United States)

    Tamano, Satoshi; Jimbo, Hayato; Azuma, Takashi; Yoshizawa, Shin; Fujiwara, Keisuke; Itani, Kazunori; Umemura, Shin-Ichiro

    2016-07-01

    Recently, in the treatment of diseases such as cancer, noninvasive or low-invasive modality, such as high-intensity focused ultrasound (HIFU), has been put into practice as an alternative to open surgery. HIFU induces thermal ablation of the target tissue to be treated. To improve the efficiency of HIFU, we have proposed a “triggered-HIFU” technique, which uses the combination of a short-duration, high-voltage transmission and a long-duration, medium-voltage transmission. In this method, the transmission device must endure high peak voltage for the former and the high time-average power for the latter. The triggered-HIFU sequence requires electronic scanning of the HIFU focus to maximize its thermal efficiency. Therefore, the transmission device must drive an array transducer with the number of elements on the order of a hundred or more, which requires that each part of the device that drives each element must be compact. The purpose of this work is to propose and construct such a transmission device by improving the staircase drive circuit, which we previously proposed. The main point of improvement is that both N and P MOSFETs are provided for each staircase voltage level instead of only one of them. Compared with the previous ultrasonic transmission circuit, high-voltage spikes were significantly reduced, the power consumption was decreased by 26.7%, and the transmission circuit temperature rise was decreased by 14.5 °C in the triggered-HIFU heating mode.

  9. [Effects of high intensity focused ultrasound with SonoVue on blood vessels pathological examinations].

    Science.gov (United States)

    Qin, Yan; Bai, Jin; Li, Faqi; Wang, Zhibiao

    2010-12-01

    The injury of tumor blood vessels will break up the nutrition supply for the tumor. In this paper, we investigated the effects exerted by high intensity focused ultrasound (HIFU) combined with ultrasound microbubble agent on blood vessels. Ultrasound diagnosis was used to find the goat hepatic blood vessels each being approximately 3mm in diameter. HIFU was focused on the blood vessels. The acoustic power was 250W; HIFU irradiating Mode was line scan (the length of the line: 10 mm; speed: 3 mm/s; irradiating time: 30s). In the experimental group, 0.03 ml/kg SonoVue was injected into the goat before HIFU irradiation,while normal saline was given to the control group. The goats were killed at 24h after HIFU irradiation, then goat liver tissues and blood vessels of target area were taken out. HE staining and Victoria's blue and Ponceau's staining of tissue section showed that the endothelial cells of blood vessels dropped off and became necrosed, and the continuity of blood vessels was interrupted. HIFU combined with SonoVue will damage large blood vessels on HIFU focus, but there is no evident discrepancy between the group with SonoVue and the group without SonoVue.

  10. Radiation from high-intensity ultrashort-laser-pulse and gas-jet magnetized plasma interaction.

    Science.gov (United States)

    Dorranian, Davoud; Starodubtsev, Mikhail; Kawakami, Hiromichi; Ito, Hiroaki; Yugami, Noboru; Nishida, Yasushi

    2003-08-01

    Using a gas-jet flow, via the interaction between an ultrashort high-intensity laser pulse and plasma in the presence of a perpendicular external dc magnetic field, the short pulse radiation from a magnetized plasma wakefield has been observed. Different nozzles are used in order to generate different densities and gas profiles. The neutral density of the gas-jet flow measured with a Mach-Zehnder interferometer is found to be proportional to back pressure of the gas jet in the range of 1 to 8 atm. Strength of the applied dc magnetic field varies from 0 to 8 kG at the interaction region. The frequency of the emitted radiation with the pulse width of 200 ps (detection limit) is in the millimeter wave range. Polarization and spatial distributions of the experimental data are measured to be in good agreement with the theory based on the V(p)xB radiation scheme, where V(p) is the phase velocity of the electron plasma wave and B is the steady magnetic field intensity. Characteristics of the radiation are extensively studied as a function of plasma density and magnetic field strength. These experiments should contribute to the development of a new kind of millimeter wavelength radiation source that is tunable in frequency, pulse duration, and intensity.

  11. Keratorefractive Effect of High Intensity Focused Ultrasound Keratoplasty on Rabbit Eyes

    Directory of Open Access Journals (Sweden)

    Zhiyu Du

    2016-01-01

    Full Text Available Purpose. To evaluate high intensity focused ultrasound (HIFU as an innovation and noninvasive technique to correct presbyopia by altering corneal curvature in the rabbit eye. Methods. Eighteen enucleated rabbit eyes were treated with a prototype HIFU keratoplasty. According to the therapy power, these eyes were divided three groups: group 1 (1 W, group 2 (2 W, and group 3 (3 W. The change in corneal power was quantified by a Sirius Scheimpflug camera. Light microscopy (LM and transmission electron microscopy (TEM were performed to determine the effect on the corneal stroma. Results. In the treated eyes, the corneal curvature increases from 49.42 ± 0.30 diopters (D and 48.00 ± 1.95 D before procedure to 51.37 ± 1.11 D and 57.00 ± 1.84 D after HIFU keratoplasty application in groups 1 and 3, respectively. The major axis and minor axis of the focal region got longer when the powers of the HIFU got increased; the difference was statistically significant (p<0.05. LM and TEM showed HIFU-induced shrinkage of corneal stromal collagen with little disturbance to the underlying epithelium. Conclusions. We have preliminarily exploited HIFU to establish a new technique for correcting presbyopia. HIFU keratoplasty will be a good application prospect for treating presbyopia.

  12. [Oxidative stress in Masters swimmers following high-intensity (interval) training (HI(I)T)].

    Science.gov (United States)

    Braun, Janina; Masoud, Magd; Brixius, Klara; Brinkmann, Christian

    2016-05-01

    Increased oxidative stress (OS) can promote diseases in the long term, but it can also trigger cellular adaptations in the short term. The present study aims to analyze whether a 3-month high-intensity (interval) training (HI(I)T) affects OS in 24 Masters swimmers (22-67 years) before (= basal) and after an all-out performance (swimming step-test). Data were analyzed for the entire group and differentiated according to sex and age (under 50 years (U50) and over 50 years (O50)). Prior to the HI(I)T intervention, a significant increase in OS from the basal to the all-out value was observed among the entire group and in the O50-subjects (subgroup analysis). Furthermore, significant increases in basal OS were evident for the entire group post-HI(I)T, but OS was only significantly increased in men in the subgroup analysis. No significant results were observed for women and U50-subjects. The response by Masters swimmers to HI(I)T depends on age and sex.

  13. PATHOMORPHISM OF PROSTATE CANCER DURING HIGH-INTENSITY FOCUSED ULTRASOUND TREATMENT

    Directory of Open Access Journals (Sweden)

    R. N. Fomkin

    2014-07-01

    Full Text Available The purpose of the study was to evaluate the efficiency of prostate cancer (PC treatment using high-intensity focused ultrasound (HIFU on the basis of morphometric and immunohistochemical (IHC analyses of postoperative prostate biopsy specimens. The study subjects were 40 patients with localized and locally advanced PC. The postoperative morphological analysis was made on the basis of standard hematoxylineosin staining and morphometric and IHC studies using the following antibodies: PCNA, Bcl-2, AMACR, Е-cadherin, and ANDR (Dako. Pre- and post-HIFU therapy histological examination of the routinely hematoxylin-eosin-stained specimens showed that the therapeutic pathomorphism of the tumor corresponded to grades III and IV. It was established that the IHC study should be used as an additional crite-rion for the efficiency of PC therapy after HIFU ablation. In spite of positive clinical, laboratory, instrumental, and objective changes, the patients with high AMACR and Bcl-2 levels and decreased Е-cadherin expression may be considered as a group at risk for prolonged malignant growth or recurrent PC.

  14. High intensity focused ultrasound technology, its scope and applications in therapy and drug delivery.

    Science.gov (United States)

    Phenix, Christopher Peter; Togtema, Melissa; Pichardo, Samuel; Zehbe, Ingeborg; Curiel, Laura

    2014-01-01

    Ultrasonography is a safe, inexpensive and wide-spread diagnostic tool capable of producing real-time non-invasive images without significant biological effects. However, the propagation of higher energy, intensity and frequency ultrasound waves through living tissues can induce thermal, mechanical and chemical effects useful for a variety of therapeutic applications. With the recent development of clinically approved High Intensity Focused Ultrasound (HIFU) systems, therapeutic ultrasound is now a medical reality. Indeed, HIFU has been used for the thermal ablation of pathological lesions; localized, minimally invasive ultrasound-mediated drug delivery through the transient formation of pores on cell membranes; the temporary disruption of skin and the blood brain barrier; the ultrasound induced break-down of blood clots; and the targeted release of drugs using ultrasound and temperature sensitive drug carriers. This review seeks to engage the pharmaceutical research community by providing an overview on the biological effects of ultrasound as well as highlighting important therapeutic applications, current deficiencies and future directions.

  15. First Experience Of Application Of High-Intensity Focused Ultrasonic Ablation (Hifu In Prostate Cancer Treatment

    Directory of Open Access Journals (Sweden)

    A.V. Stativko

    2009-12-01

    Full Text Available The scientific article points out that 40 sessions of HIFU prostate ablation have been performed for estimation of clinical efficiency. Average frequency of influences presents 628±164 impulses; average volume of tissues subjected to influence during one procedure is 33,8±16,3 smi (132 % of prostate volume; average operation time constitutes 150 minutes (from 90 to 200 minutes. During the operation no complications have been occurred. In the first days after the session of HIFU there was a peak of PSA increase and then during 1,5-3 months there was decrease to the lowest index. Minimal PSA level was reached in 10-12 weeks after treatment and it constituted from 0,04 till 1,1 ngml depending on the disease state. Reduction of prostate volume occurred in average from the 30th day of postoperative period and lasted for 6 months, reaching in average 50 % from initial volume. Postoperative period varied from 10 till 16 days and constituted in average 12±0,8 days. Thus application of high-intensity focused ultrasonic ablation allows treating successfully various stages of prostate cancer with minimal number of side-effects and makes possible the early estimation of treatment efficiency

  16. Time Integrated Soft X-ray Imaging in High Intensity Laser Experiments (thesis)

    Energy Technology Data Exchange (ETDEWEB)

    Stafford, David [Univ. of California, Davis, CA (United States)

    2009-01-01

    2009 marks a significant achievement and the dawn of a new era in high intensity laser research with the final commissioning of all 192 beams at the National Ignition Facility (NIF). NIF is a department of energy (DOE) funded project more than 10 years in the making located at the Lawrence Livermore National Laboratory (LLNL). The following research was done as one of many preliminary experiments done to prepare for these historic events. The primary focus of the experimental campaign this paper addresses is to test and develop a thermal x-radiation source using a short pulse laser. This data is hoped to provide information about the thermal transport mechanisms important in the development of prediction models in High Energy Density (HED) science. One of several diagnostics fielded was a soft x-ray imager (SXRI) which is detailed in this paper. The SXRI will be used to measure the relative size of the heated region and also the relative level of specific x-ray emissions among several shot and target configurations. The laser system used was the Titan laser located in the Jupiter Laser Facility (JLF) at Lawrence Livermore National Laboratory (LLNL). Titan uses the JLF Janus Nd:glass laser west frontend system with a Optical Parametric Chirped Pulse Amplification (OPCPA) in place of the nanosecond oscillator. The system is capable of producing laser intensities of over a petawatt with several tens of joules delivered in the beam.

  17. Spontaneous transitions in atomic system in the presence of high-intensity laser field

    Science.gov (United States)

    Bogatskaya, Anna; Volkova, Ekaterina; Popov, Alexander

    2016-10-01

    A new approach to the study of the spontaneous emission of the quantum system driven by a high-intensity laser field is developed. This approach is based on the accurate consideration of quantum system interaction with vacuum quantized field modes in the first order of perturbation theory, while the intense laser field is considered classically beyond the perturbation theory which allows to observe any-order stimulated processes governed by classical field. The proposed approach is applied to the study of a number of quantum systems in intense laser field. The obtained data are compared with those obtained in the frames of semiclassical approximation typically used for analyzing of the strong-field dynamic. It is found that the applicability of the semiclassical approach is strictly limited. It is valid for calculation of transitions to the initially populated state only if the population of this state is close to unity during the pulse and in the after-pulse regime. If its population is depleted, the semiclassical approach fails.

  18. Analgesic effect of high intensity focused ultrasound in patients with advanced pancreatic cancer

    Institute of Scientific and Technical Information of China (English)

    Xinjin Tan; Jian Chen; Li Ren; Ruilu Lin; Zailian Chen

    2013-01-01

    Objective:The aim of this study was to evaluate the analgesic ef ect of high intensity focused ultrasound (HIFU) in patients with advanced pancreatic cancer. Methods:A total of 106 patients with advanced pancreatic cancer accompanied by abdominal pain were treated by HIFU. Pain intensities and quantities of morphine consumption before and after treatment were observed and compared. Results:The average pain intensities before treatment, and at d3, d7 after treatment were 5.80 ± 2.14, 2.73 ± 2.68, 2.45 ± 2.43 respectively (P<0.01). Fifty-nine cases (55.7%) got to extremely ef ective, and 29 cases (27.4%) ef ective. Total ef icient rate was 83.0%. The average quantities of morphine consumption before and after treatment in the patients with grade III pain were 114.9 ± 132.5 mg, 16.8 ± 39.7 mg each person everyday respectively (P<0.01). Conclusion:HIFU can relieve pain suf ered by patients with pancreatic cancer ef ectively. It is a new adjuvant treatment for pancreatic cancer pain.

  19. Does whole-body cryotherapy improve vertical jump recovery following a high-intensity exercise bout?

    Science.gov (United States)

    Vieira, Amilton; Bottaro, Martim; Ferreira-Junior, Joao B; Vieira, Carlos; Cleto, Vitor A; Cadore, Eduardo L; Simões, Herbert G; Carmo, Jake Do; Brown, Lee E

    2015-01-01

    Whole-body cryotherapy (WBC) has been used as a recovery strategy following different sports activities. Thus, the aim of the study reported here was to examine the effect of WBC on vertical jump recovery following a high-intensity exercise (HIE) bout. Twelve trained men (mean ± standard deviation age = 23.9±5.9 years) were randomly exposed to two different conditions separated by 7 days: 1) WBC (3 minutes of WBC at −110°C immediately after the HIE) and 2) control (CON; no WBC after the HIE). The HIE consisted of six sets of ten repetitions of knee extensions at 60° · s−1 concentric and 180° · s−1 eccentric on an isokinetic dynamometer. The vertical jump test was used to evaluate the influence of HIE on lower extremity muscular performance. The vertical jump was performed on a force platform before HIE (T1) and 30 minutes after (T2) the WBC and CON conditions. As a result of HIE, jump height, muscle power, and maximal velocity (Vmax) had significant decreases between T1 and T2, however no significance was found between the WBC and CON conditions. The results indicate that one session of WBC had no effect on vertical jump following an HIE compared with a CON condition. WBC may not improve muscle-function (dependent on stretch-shortening cycle) recovery in very short periods (ie, 30 minutes) following HIE. PMID:25750548

  20. A Pilot Study Investigating the Potential of High-Intensity Focused Ultrasound to Treat Tumours Rapidly

    Science.gov (United States)

    Cranston, Jonathan M.; Rivens, Ian; ter Haar, Gail; Kennedy, James

    2007-05-01

    The aim of this project was to investigate the possibility of rapid tumour destruction by a novel method of treating the periphery of a tumour and inducing ischemia by impeding the blood supply. Ex vivo experiments were initially carried out in bovine liver to determine the optimum conditions for focal depth, gantry transducer speed circle diameter and intensity of the ultrasound beam. In vivo experiments were then performed in PGV rat livers implanted with a HSN fibrosarcoma cell line. The tumours were treated by novel technique of creating an annular lesion around the perimeter of the tumour. Macroscopic and microscopic examination of the lesion at post mortem was performed. In addition histological examination of the untreated tumour which was within the annular circle of treatment was examined. This showed evidence of karyolytic nuclei a week after treatment suggesting death by infarction within this area. There was also some evidence of endothelial damage in the blood vessels with fragmented nuclei visible in the lumen. The work presented here adds to our understanding of how high intensity focused ultrasound may be used to treat tumours in as faster and more efficient way. Further work in this area will facilitate the design of future therapeutic interventions in the medical and veterinary world.

  1. Estimated Aerobic Capacity Changes in Adolescents with Obesity Following High Intensity Interval Exercise

    Directory of Open Access Journals (Sweden)

    Brooke E. Starkoff

    2014-07-01

    Full Text Available Vigorous aerobic exercise may improve aerobic capacity (VO2max and cardiometabolic profiles in adolescents with obesity, independent of changes to weight. Our aim was to assess changes in estimated VO2max in obese adolescents following a 6-week exercise program of varying intensities. Adolescents with obesity were recruited from an American mid-west children’s hospital and randomized into moderate exercise (MOD or high intensity interval exercise (HIIE groups for a 6-week exercise intervention, consisting of cycle ergometry for 40 minutes, 3 days per week. Heart rate was measured every two minutes during each exercise session.  Estimated VO2max measured via Åstrand cycle test, body composition, and physical activity (PA enjoyment evaluated via questionnaire were assessed pre/post-intervention. Twenty-seven adolescents (age 14.7±1.5; 17 female, 10 male completed the intervention. Estimated VO2max increased only in the HIIE group (20.0±5.7 to 22.7±6.5 ml/kg/min, p=0.015. The HIIE group also demonstrated increased PA enjoyment, which was correlated with average heart rate achieved during the intervention (r=0.55; p=0.043. Six weeks of HIIE elicited improvements to estimated VO2max in adolescents with obesity. Furthermore, those exercising at higher heart rates demonstrated greater PA enjoyment, implicating enjoyment as an important determinant of VO2max, specifically following higher intensity activities.

  2. Tracking Perfluorocarbon Nanoemulsion Delivery by 19F MRI for Precise High Intensity Focused Ultrasound Tumor Ablation

    Science.gov (United States)

    Shin, Soo Hyun; Park, Eun-Joo; Min, Changki; Choi, Sun Il; Jeon, Soyeon; Kim, Yun-Hee; Kim, Daehong

    2017-01-01

    Perfluorocarbon nanoemulsions (PFCNEs) have recently been undergoing rigorous study to investigate their ability to improve the therapeutic efficacy of tumor ablation by high intensity focused ultrasound (HIFU). For precise control of PFCNE delivery and thermal ablation, their accumulation and distribution in a tumor should be quantitatively analyzed. Here, we used fluorine-19 (19F) magnetic resonance imaging (MRI) to quantitatively track PFCNE accumulation in a tumor, and analyzed how intra-tumoral PFCNE quantities affect the therapeutic efficacy of HIFU treatment. Ablation outcomes were assessed by intra-voxel incoherent motion analysis and bioluminescent imaging up to 14 days after the procedure. Assessment of PFCNE delivery and treatment outcomes showed that 2-3 mg/mL of PFCNE in a tumor produces the largest ablation volume under the same HIFU insonation conditions. Histology showed varying degrees of necrosis depending on the amount of PFCNE delivered. 19F MRI promises to be a valuable platform for precisely guiding PFCNE-enhanced HIFU ablation of tumors. PMID:28255351

  3. Role of acoustic interface layer during high intensity focused ultrasound therapeutics

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    After interface layer was simulated by the magnetic nano-particles in the egg white phantom, high intensity focused ultrasound (HIFU) at the same dosage was introduced to radiate the phantom in different depths to blow the acoustic interface layer to mimic "point" exposure. The results showed that the volumes of biological focal region (BFR) were enlarged when the acoustic focal region (AFR) is close with interface layer. This meant that the magnetic nano-particles enhanced the therapeutic efficiency of HIFU. When the distance of the AFR from the interface layer was 10 mm, the size and shape of the BFR were similar with those of the control group, but a larger lesion at the interface, which was harmful for treatment, was observed. When the distance of the AFR to the interface layer increased to 30 mm, the size and shape of the BFR were also similar to those of the control group. When the thickness of the interface layer diminished, the utility of enhancement decreased. Continuous increase of the safe area for treatment and decrease of the utility of enhancement were observed along with the abatement of the thickness of the interface layer

  4. High-density operation of the Proto-MPEX High Intensity Plasma Source

    Science.gov (United States)

    Caughman, J. B. O.; Goulding, R. H.; Biewer, T. M.; Bigelow, T. S.; Campbell, I. H.; Caneses, J.; Diem, S. J.; Martin, E. H.; Parish, C. M.; Rapp, J.; Ray, H. B.; Shaw, G. C.; Showers, M. A.; Donovan, D.; Piotrowicz, P. A.; Martin, D. C.

    2016-10-01

    The Prototype Materials Plasma Experiment (Proto-MPEX) is a linear high-intensity RF plasma source that combines a high-density helicon plasma generator with ion and electron heating sections. It is being used to study the physics of heating over-dense plasmas in a linear configuration with the goal of delivering a plasma heat flux of 10 MW/m2 at a target. The helicon plasma is produced by coupling 13.56 MHz RF power at levels of >100 kW. A 30 kW ion cyclotron antenna has recently been installed, and microwaves at 28 GHz ( 150 kW) are coupled to the electrons in the over-dense helicon plasma via Electron Bernstein Waves (EBW). High plasma densities near the target have been produced in D ( 5 x1019/m3) , and electron temperatures range from 3 to >10 eV, depending on the source parameters. IR camera images of the target plate indicate plasma heat depositions >10 MW/m2 for some operating conditions. Details of the experimental results of the operational domain with respect to Te and ne as well as results from initial plasma material interaction tests will be presented. ORNL is managed by UT-Battelle, LLC, for the U.S. DOE under contract DE-AC-05-00OR22725.

  5. Development and characterization of a blood mimicking fluid for high intensity focused ultrasound.

    Science.gov (United States)

    Liu, Yunbo; Maruvada, Subha; King, Randy L; Herman, Bruce A; Wear, Keith A

    2008-09-01

    A blood mimicking fluid (BMF) has been developed for the acoustic and thermal characterizations of high intensity focused ultrasound (HIFU) ablation devices. The BMF is based on a degassed and de-ionized water solution dispersed with low density polyethylene microspheres, nylon particles, gellan gum, and glycerol. A broad range of physical parameters, including attenuation coefficient, speed of sound, viscosity, thermal conductivity, and diffusivity, were characterized as a function of temperature (20-70 degrees C). The nonlinear parameter B/A and backscatter coefficient were also measured at room temperature. Importantly, the attenuation coefficient is linearly proportional to the frequency (2-8 MHz) with a slope of about 0.2 dB cm(-1) MHz(-1) in the 20-70 degrees C range as in the case of human blood. Furthermore, sound speed and bloodlike backscattering indicate the usefulness of the BMF for ultrasound flow imaging and ultrasound-guided HIFU applications. Most of the other temperature-dependent physical parameters are also close to the reported values in human blood. These properties make it a unique HIFU research tool for developing standardized exposimetry techniques, validating numerical models, and determining the safety and efficacy of HIFU ablation devices.

  6. Effectiveness of High Intensity Laser Therapy for Reduction of Pain in Knee Osteoarthritis

    Science.gov (United States)

    2016-01-01

    Introduction. Osteoarthritis is the most common type of arthritis. It is the main cause of chronic musculoskeletal pain and disability among the elderly population. Aim. This is a pilot, randomized clinical study about the effect of high intensity laser therapy in patients with osteoarthritis of the knee (OA of the knee). Material and Method. 72 patients (aged between 39 and 83 years) with (clinically and radiographically proved) OA of the knee were included in the study. They were randomized in two groups: therapeutic (test) one (n = 37, 65,11 ± 1,40 (mean ± SD) years old; patients were treated with HILT) and control group (n = 35, 64,71 ± 1,98; patients receive sham laser). Both groups had seven sessions of treatment. VAS and dolorimetry were used for assessment of pain before and after the therapy. Pedobarometric analysis (static and dynamic) was used to assess comparatively the contact surface area and maximum pressure under the heel. Results. Pain levels measured by VAS and dolorimetry decreased significantly in the therapeutic group after seven days of treatment (ptherapy in comparison to sham laser. This is the reason why HILT can be a method of choice in the treatment of gonarthrosis. PMID:28096711

  7. Warm-up strategy and high-intensity endurance performance in trained cyclists

    DEFF Research Database (Denmark)

    Christensen, Peter Møller; Bangsbo, Jens

    2015-01-01

    ; means±SD) performed three warm-up strategies lasting 20 min before a 4-min maximal performance test (PT). Strategies consisted of moderate intensity exercise (50%iPPO) followed by 6 min of recovery (MOD6) or progressive-high intensity exercise (10-100%iPPO and 2x20-s sprints) followed by recovery for 6...... to HI20 (7.85±0.82 L; P=0.008) and MOD6 (7.90±0.74 L; P=0.012). CONCLUSIONS: Warm-up exercise including race-pace and sprint intervals combined with short recovery can reduce subsequent performance in a 4-min maximal test in highly trained cyclists. Thus, a reduced time at high exercise intensity......PURPOSE: To evaluate the influence of warm-up exercise intensity and subsequent recovery on intense endurance performance, selected blood variables and the VO2 response. METHODS: Twelve highly trained male cyclists (VO2-max: 72.4±8.0·mL/min/kg, incremental-test peak power output (iPPO): 432±31 W...

  8. High-intensity interval training vs. repeated-sprint training in tennis.

    Science.gov (United States)

    Fernandez-Fernandez, Jaime; Zimek, Rico; Wiewelhove, Thimo; Ferrauti, Alexander

    2012-01-01

    The aim of this study was to compare the effects of high-intensity interval training (HIIT) and repeated-sprint training (RST) on aerobic fitness, tennis-specific endurance, linear and repeated-sprint ability (RSA), and jumping ability. Thirty-one competitive male tennis players took part in a training intervention of 6 weeks. The players were matched into 3 groups, HIIT (n = 11), RST (n = 12), or control group (CON, n = 9). The results showed significant time × intervention interactions for VO(2)peak, with a significant increase in the VO(2)peak level of 6.0% in HIIT (p = 0.008) and 4.9% in RST (p = 0.010), whereas no changes occurred in CON. However, the following differences were found between the intervention groups: The HIIT-induced greater improvements in tennis-specific endurance (HIIT 28.9% vs. RST 14.5%; p training strategy induced any effects on jumping and sprinting abilities. Both training interventions showed similar improvements in general aerobic fitness. Also, the present results suggest that RST represents a time-efficient stimulus for a simultaneous improvement of general and tennis-specific aerobic fitness as well for RSA.

  9. Acute high-intensity sound exposure alters responses of place cells in hippocampus.

    Science.gov (United States)

    Goble, T J; Møller, A R; Thompson, L T

    2009-07-01

    Overstimulation is known to activate neural plasticity in the auditory nervous system causing changes in function and re-organization. It has been shown earlier that overstimulation using high-intensity noise or tones can induce signs of tinnitus. Here we show in studies in rats that overstimulation causes changes in the way place cells of the hippocampus respond as rats search for rewards in a spatial maze. In familiar environments, a subset of hippocampal pyramidal neurons, known as place cells, respond when the animal moves through specific locations but are relatively silent in others. This place-field activity (i.e. location-specific firing) is stable in a fixed environment. The present study shows that activation of neural plasticity through overstimulation by sound can alter the response of these place cells. Rats implanted with chronic drivable dorsal hippocampal tetrodes (four microelectrodes) were assessed for stable single-unit place-field responses that were extracted from multiunit responses using NeuroExplorer computer spike-sorting software. Rats then underwent either 30 min exposure to a 4 kHz tone at 104 dB SPL or a control period in the same sound chamber. The place-field activity was significantly altered after sound exposure showing that plastic changes induced by overstimulation are not limited to the auditory nervous system but extend to other parts of the CNS, in this case to the hippocampus, a brain region often studied in the context of plasticity.

  10. Cellular Stress Response Gene Expression During Upper and Lower Body High Intensity Exercises

    Science.gov (United States)

    Kochanowicz, Andrzej; Sawczyn, Stanisław; Niespodziński, Bartłomiej; Mieszkowski, Jan; Kochanowicz, Kazimierz

    2017-01-01

    Objectives The aim was to compare the effect of upper and lower body high-intensity exercise on chosen genes expression in athletes and non-athletes. Method Fourteen elite male artistic gymnasts (EAG) aged 20.6 ± 3.3 years and 14 physically active men (PAM) aged 19.9 ± 1.0 years performed lower and upper body 30 s Wingate Tests. Blood samples were collected before, 5 and 30 minutes after each effort to assess gene expression via PCR. Results Significantly higher mechanical parameters after lower body exercise was observed in both groups, for relative power (8.7 ± 1.2 W/kg in gymnasts, 7.2 ± 1.2 W/kg in controls, p = 0.01) and mean power (6.7 ± 0.7 W/kg in gymnasts, 5.4 ± 0.8 W/kg in controls, p = 0.01). No differences in lower versus upper body gene expression were detected for all tested genes as well as between gymnasts and physical active man. For IL-6 m-RNA time-dependent effect was observed. Conclusions Because of no significant differences in expression of genes associated with cellular stress response the similar adaptive effect to exercise may be obtained so by lower and upper body exercise. PMID:28141870

  11. Ultrasonic atomization of tissue and its role in tissue fractionation by high intensity focused ultrasound

    Science.gov (United States)

    Simon, Julianna C.; Sapozhnikov, Oleg A.; Khokhlova, Vera A.; Wang, Yak-Nam; Crum, Lawrence A.; Bailey, Michael R.

    2012-12-01

    Atomization and fountain formation is a well-known phenomenon that occurs when a focused ultrasound wave in liquid encounters an air interface. High intensity focused ultrasound (HIFU) has been shown to fractionate a tissue into submicron-sized fragments in a process termed boiling histotripsy, wherein the focused ultrasound wave superheats the tissue at the focus, producing a millimetre-sized boiling or vapour bubble in several milliseconds. Yet the question of how this millimetre-sized boiling bubble creates submicron-sized tissue fragments remains. The hypothesis of this work is that the tissue can behave as a liquid such that it atomizes and forms a fountain within the vapour bubble produced in boiling histotripsy. We describe an experiment, in which a 2 MHz HIFU transducer (maximum in situ intensity of 24 000 W cm-2) was aligned with an air-tissue interface meant to simulate the boiling bubble. Atomization and fountain formation was observed with high-speed photography and resulted in tissue erosion. Histological examination of the atomized tissue showed whole and fragmented cells and nuclei. Air-liquid interfaces were also filmed. Our conclusion was that HIFU can fountain and atomize tissue. Although this process does not entirely mimic what was observed in liquids, it does explain many aspects of tissue fractionation in boiling histotripsy.

  12. Continuous and high-intensity interval training: which promotes higher pleasure?

    Directory of Open Access Journals (Sweden)

    Bruno R R Oliveira

    Full Text Available OBJECTIVES: To compare the psychological responses to continuous (CT and high-intensity interval training (HIT sessions. METHODS: Fifteen men attended one CT session and one HIT session. During the first visit, the maximum heart rate, VO2Peak and respiratory compensation point (RCP were determined through a maximal cardiopulmonary exercise test. The HIT stimulus intensity corresponded to 100% of VO2Peak, and the average intensity of both sessions was maintained at 15% below the RCP. The order of the sessions was randomized. Psychological and physiological variables were recorded before, during and after each session. RESULTS: There were no significant differences between the average percentages of VO2 during the two exercise sessions (HIT: 73.3% vs. CT: 71.8%; p = 0.779. Lower responses on the feeling scale (p≤0.01 and higher responses on the felt arousal scale (p≤0.001 and the rating of perceived exertion were obtained during the HIT session. Despite the more negative feeling scale responses observed during HIT and a greater feeling of fatigue (measured by Profile of Mood States afterwards (p<0.01, the physical activity enjoyment scale was not significantly different between the two conditions (p = 0.779. CONCLUSION: Despite the same average intensity for both conditions, similar psychological responses under HIT and CT conditions were not observed, suggesting that the higher dependence on anaerobic metabolism during HIT negatively influenced the feeling scale responses.

  13. Acoustic power measurement of high-intensity focused ultrasound transducer using a pressure sensor.

    Science.gov (United States)

    Zhou, Yufeng

    2015-03-01

    The acoustic power of high-intensity focused ultrasound (HIFU) is an important parameter that should be measured prior to each treatment to guarantee effective and safe outcomes. A new calibration technique was developed that involves estimating the pressure distribution, calculating the acoustic power using an underwater pressure blast sensor, and compensating the contribution of harmonics to the acoustic power. The output of a clinical extracorporeal HIFU system (center frequency of ~1 MHz, p+ = 2.5-57.2 MPa, p(-) = -1.8 to -13.9 MPa, I(SPPA) = 513-22,940 W/cm(2), -6 dB size of 1.6 × 10 mm: lateral × axial) was measured using this approach and then compared with that obtained using a radiation force balance. Similarities were found between each method at acoustic power ranging from 18.2 W to 912 W with an electrical-to-acoustic conversion efficiency of ~42%. The proposed method has advantages of low weight, smaller size, high sensitivity, quick response, high signal-to-noise ratio (especially at low power output), robust performance, and easy operation of HIFU exposimetry measurement.

  14. Comparison between Epidural Block vs. High Intensity Laser Therapy for Controlling Chronic Low Back Pain

    Directory of Open Access Journals (Sweden)

    Badiozaman Radpay

    2016-01-01

    Full Text Available Background: Chronic low back pain is among a wide spread musculoskeletal conditions that is related to disability with high economy cost. There are several treatment modalities for controlling chronic low back pain (CLBP, among them high intensity laser therapy (HILT and epidural blocks (EB use more commonly. This study aimed to evaluate the benefits and hazards of each of these two methods.Materials and Methods: We designed a randomized controlled double blind study during 24 months.101 patients divided in 2 groups (52 in EB and 49 in HILT group. Pain intensity was assessed by using faces pain scales (FPS and LINKERT questionaries' before procedure and during one, four, 12, and 24 weeks after beginning the procedures.Results: There were no differences between two groups in FPS lumber tenderness, straight leg rising test (SLRT, paresthesia, deep tendon reflex (DTR, and imaging changes. Motor problems seem was less in HILT group comparing EB.Conclusion: This study showed both EB and HILT approaches can control the pain intensity and motor activities in CLBP patients. Future studies will clarify the precise importance of each these methods.

  15. Feasibility study on photoacoustic guidance for high-intensity focused ultrasound-induced hemostasis

    Science.gov (United States)

    Nguyen, Van Phuc; Kim, Jeehyun; Ha, Kang-lyeol; Oh, Junghwan; Kang, Hyun Wook

    2014-10-01

    The feasibility of photoacoustic imaging (PAI) application was evaluated to map punctured blood vessels thermally treated by high-intensity focused ultrasound (HIFU) for hemostasis. A single-element HIFU transducer with a central frequency of 2.0 MHz, was used to induce thermal hemostasis on the punctured arteries. The HIFU-treated lesion was imaged and localized by high-contrast PAI guidance. The results showed that complete hemostasis was achieved after treatment of the damaged blood vessels within 25 to 52 s at the acoustic intensity of 3600 W/cm2. The coagulation time for the animal artery was ˜20% longer than that of the phantom possibly due to a lower Young's modulus. The reconstructed PA images were able to distinguish the treated area from the surrounding tissue in terms of augmented signal amplitudes (up to three times). Spectroscopic studies demonstrated that the optimal imaging wavelength was found to be 700 nm in order to reconstruct high-contrast photoacoustic images on HIFU-treated lesions. The proposed PAI integrated with HIFU treatment can be a feasible application to obtain safe and rapid hemostasis for acute arterial bleeding.

  16. STATUS REPORT ON DEVELOPMENT OF A HIGH-SPEED HIGH-INTENSITY MOLECULAR BEAM

    Energy Technology Data Exchange (ETDEWEB)

    Knuth, Eldon L.

    1963-07-15

    Status of a high-speed high-intensity molecular beam under development is described. Bases for designs of the several components are presented. Using an arc-heated source and a hypersonic jet, molecular energies exceeding 1 ev and beam intensities of the order of 10/sup 16/ molecules/ cm/sup 2/ sec are anticipated. A two-disk beam chopper and speed selector provides a means for analyzing the speed distribution in the generated beam, for chopping the beam into bursts of nearly monoenergetic molecules suitable for scattering studies using the time-of-flight technique, and for modulating the beam in order to facilitate detection. A through-flow ionization detector possesses the versatility required for scattering studies using the time-of-flight technique. A sorption pump and a turbo pump serve as central components of alternative pumping systems for the collimating chamber. Using the arc-heated source, the converging nozzle, the conduction-radiation-cooled skimmer, the turbo pump (turning at 3400 rpm), the chopperselector (acting only as a chopper), and the detector, an arc-heated beam is generated and detected. (auth)

  17. Effect of high-intensity intermittent cycling sprints on neuromuscular activity.

    Science.gov (United States)

    Billaut, F; Basset, F A; Giacomoni, M; Lemaître, F; Tricot, V; Falgairette, G

    2006-01-01

    High-intensity intermittent sprints induce changes in metabolic and mechanical parameters. However, very few data are available about electrical manifestations of muscle fatigue following such sprints. In this study, quadriceps electromyographic (EMG) responses to repeated all-out exercise bouts of short duration were assessed from maximal voluntary isometric contractions (MVC) performed before and after sprints. Twelve men performed ten 6-s maximal cycling sprints, separated by 30-s rest. The MVC were performed pre-sprints ( pre), post-sprints ( post), and 5 min post-sprints ( post5). Values of root-mean-square (RMS) and median frequency (MF) of vastus lateralis (VL) and vastus medialis (VM) were recorded during each MVC. During sprints, PPO decreased significantly in sprints 8, 9, and 10, compared to sprint 1 (- 8 %, - 10 %, and - 11 %, respectively, p MVC post (- 13 %, p MVC post5 (- 10.5 %, p MVC pre. The RMS value of VL muscle increased significantly after sprints (RMS pre vs. RMS post: + 15 %, p pattern of muscle fiber recruitment, and a decrease in conduction velocity of active fibers.

  18. The Effects of High Intensity Interval Training vs Steady State Training on Aerobic and Anaerobic Capacity

    Directory of Open Access Journals (Sweden)

    Carl Foster, Courtney V. Farland, Flavia Guidotti, Michelle Harbin, Brianna Roberts, Jeff Schuette, Andrew Tuuri, Scott T. Doberstein, John P. Porcari

    2015-12-01

    Full Text Available High intensity interval training (HIIT has become an increasingly popular form of exercise due to its potentially large effects on exercise capacity and small time requirement. This study compared the effects of two HIIT protocols vs steady-state training on aerobic and anaerobic capacity following 8-weeks of training. Fifty-five untrained college-aged subjects were randomly assigned to three training groups (3x weekly. Steady-state (n = 19 exercised (cycle ergometer 20 minutes at 90% of ventilatory threshold (VT. Tabata (n = 21 completed eight intervals of 20s at 170% VO2max/10s rest. Meyer (n = 15 completed 13 sets of 30s (20 min @ 100% PVO2 max/ 60s recovery, average PO = 90% VT. Each subject did 24 training sessions during 8 weeks. Results: There were significant (p < 0.05 increases in VO2max (+19, +18 and +18% and PPO (+17, +24 and +14% for each training group, as well as significant increases in peak (+8, + 9 and +5% & mean (+4, +7 and +6% power during Wingate testing, but no significant differences between groups. Measures of the enjoyment of the training program indicated that the Tabata protocol was significantly less enjoyable (p < 0.05 than the steady state and Meyer protocols, and that the enjoyment of all protocols declined (p < 0.05 across the duration of the study. The results suggest that although HIIT protocols are time efficient, they are not superior to conventional exercise training in sedentary young adults.

  19. Acute molecular responses to concurrent resistance and high-intensity interval exercise in untrained skeletal muscle.

    Science.gov (United States)

    Pugh, Jamie K; Faulkner, Steve H; Jackson, Andrew P; King, James A; Nimmo, Myra A

    2015-04-01

    Concurrent training involving resistance and endurance exercise may augment the benefits of single-mode training for the purpose of improving health. However, muscle adaptations, associated with resistance exercise, may be blunted by a subsequent bout of endurance exercise, via molecular interference. High-intensity interval training (HIIT), generating similar adaptations to endurance exercise, may offer an alternative exercise mode to traditional endurance exercise. This study examined the influence of an acute HIIT session on the molecular responses following resistance exercise in untrained skeletal muscle. Ten male participants performed resistance exercise (4 × 8 leg extensions, 70% 1RM, (RE)) or RE followed by HIIT (10 × 1 min at 90% HRmax, (RE+HIIT)). Muscle biopsies were collected from the vastus lateralis before, 2 and 6 h post-RE to determine intramuscular protein phosphorylation and mRNA responses. Phosphorylation of Akt (Ser(473)) decreased at 6 h in both trials (P HIIT (P HIIT with PGC-1α and PGC-1α-ex1b remaining elevated at 6 h, whereas RE-induced increases at 2 and 6 h for PGC-1α-ex1b only (P HIIT versus RE at 2 and 6 h (P HIIT may be an alternative to endurance exercise when performed after resistance exercise in the same training session to optimize adaptations.

  20. High-intensity interval training in patients with coronary heart disease: Prescription models and perspectives.

    Science.gov (United States)

    Ribeiro, Paula A B; Boidin, Maxime; Juneau, Martin; Nigam, Anil; Gayda, Mathieu

    2017-01-01

    Recently, high-intensity interval training (HIIT) has emerged as an alternative and/or complementary exercise modality to continuous aerobic exercise training (CAET) in CHD patients. However, the literature contains descriptions of many HIIT protocols with different stage durations, nature of recovery and intensities. In this review, we discuss the most recent forms of validated HIIT protocols in patients with coronary heart disease (CHD) and how to prescribe and use them during short- and long-term (phase II and III) cardiac rehabilitation programs. We also compare the superior and/or equivalent short- and long-term effects of HIIT versus CAET on aerobic fitness, cardiovascular function, and quality of life; their efficiency, safety, and tolerance; and exercise adherence. Short interval HIIT was found beneficial for CHD patients with lower aerobic fitness and would ideally be used in initiation and improvement stages. Medium and/or long interval HIIT protocols may be beneficial for CHD patients with higher aerobic fitness, and would be ideally used in the improvement and maintenance stages because of their high physiological stimulus. Finally, we propose progressive individualized models of HIIT programs (phase II to III) for patients with CHD and how to ideally use them according to the clinical status of patients and phase of the cardiac rehabilitation program.

  1. Multimodal high-intensity interval training increases muscle function and metabolic performance in females.

    Science.gov (United States)

    Buckley, Stephanie; Knapp, Kelly; Lackie, Amy; Lewry, Colin; Horvey, Karla; Benko, Chad; Trinh, Jason; Butcher, Scotty

    2015-11-01

    High-intensity interval training (HIIT) is a time-efficient method of improving aerobic and anaerobic power and capacity. In most individuals, however, HIIT using modalities such as cycling, running, and rowing does not typically result in increased muscle strength, power, or endurance. The purpose of this study is to compare the physiological outcomes of traditional HIIT using rowing (Row-HIIT) with a novel multimodal HIIT (MM-HIIT) circuit incorporating multiple modalities, including strength exercises, within an interval. Twenty-eight recreationally active women (age 24.7 ± 5.4 years) completed 6 weeks of either Row-HIIT or MM-HIIT and were tested on multiple fitness parameters. MM-HIIT and Row-HIIT resulted in similar improvements (p HIIT group had significant (p HIIT group had no increase in any muscle performance variable (p values 0.33-0.90). Post-training, 1-repetition maximum (1RM) squat (64.2 ± 13.6 vs. 45.8 ± 16.2 kg, p = 0.02), 1RM press (33.2 ± 3.8 vs. 26.0 ± 9.6 kg, p = 0.01), and squat endurance (23.9 ± 12.3 vs. 10.2 ± 5.6 reps, p HIIT group than in the Row-HIIT group. MM-HIIT resulted in similar aerobic and anaerobic adaptations but greater muscle performance increases than Row-HIIT in recreationally active women.

  2. Complications of high intensity focused ultrasound in patients with recurrent and metastatic abdominal tumors

    Institute of Scientific and Technical Information of China (English)

    Jian-Jun Li; Guo-Liang Xu; Mo-Fa Gu; Guang-Yu Luo; Zhang Rong; Pei-Hong Wu; Jian-Chuan Xia

    2007-01-01

    AIM: To analyze the local and systemic complications of high intensity focused ultrasound (HIFU) for patients with recurrent and metastatic abdominal tumors.METHODS: From Aug 2001 to Aug 2004, 17 patients with recurrent and metastatic abdominal tumors were enrolled in this study. Real-time sonography was taken, and vital signs, liver and kidney function, skin burns, local reactions, and systemic effects were observed and recored before, during, and after HIFU. CT and MRI were also taken before and after HIFU.RESULTS: All 17 patients had skin burns and pAln in the treatment region; the next common complication was neurapraxia of the stomach and intestines to variable degrees. The other local and systemic complications were relatively rare. Severe complications were present in two patients; one developed a superior mesenteric artery infarction resulting in necrosis of the entire small intestines, and the other one suffered from a perforation in terminal ileum due to HIFU treatment.CONCLUSION: Although HIFU is a one of noninvasive treatments for the recurrent and metastatic abdominal tumors, there are still some common and severe complications which need serious consideration.

  3. Fatal asbestosis 50 years after brief high intensity exposure in a vermiculite expansion plant.

    Science.gov (United States)

    Wright, Robert S; Abraham, Jerrold L; Harber, Philip; Burnett, Bryan R; Morris, Peter; West, Phil

    2002-04-15

    The authors report the case of a 65-year-old accountant whose only asbestos exposure was during a summer job 50 years earlier in a California vermiculite expansion plant. Vermiculite is a silicate material that is useful in building and agriculture as a filler and insulating agent. He developed extensive fibrocalcific pleural plaques and end-stage pulmonary fibrosis, with rapidly progressive respiratory failure. Careful occupational and environmental history revealed no other source of asbestos exposure, and the initial clinical diagnosis was idiopathic pulmonary fibrosis; open lung biopsy shortly before his death confirmed asbestosis. Electron microscopic lung fiber burden analysis revealed over 8,000,000 asbestos fibers per gram dry lung, 68% of which were tremolite asbestos. Additional asbestiform fibers of composition not matching any of the standard asbestos varieties were also present at over 5,000,000 fibers per gram dry lung. Comparison analysis of a sample of Libby, Montana, vermiculite showed a similar mix of asbestiform fibers including tremolite asbestos. This case analysis raises several concerns: risks of vermiculite induced disease among former workers of the more than 200 expansion plants throughout the United States; health effects of brief but very high-intensity exposures to asbestos; and possible health effects in end-users of consumer products containing vermiculite.

  4. Simulation of the Beam Dump for a High Intensity Electron Gun

    CERN Document Server

    Doebert, S; Lefevre, T; Pepitone, K

    2014-01-01

    The CLIC Drive Beam is a high-intensity pulsed electron beam. A test facility for the Drive Beam electron gun will soon be commissioned at CERN. In this contribution we outline the design of a beam dump / Faraday cup capable of resisting the beam’s thermal load. The test facility will operate initially up to 140 keV. At such low energies, the electrons are absorbed very close to the surface of the dump, leading to a large energy deposition density in this thin layer. In order not to damage the dump, the beam must be spread over a large surface. For this reason, a small-angled cone has been chosen. Simulations using Geant4 have been performed to estimate the distribution of energy deposition in the dump. The heat transport both within the electron pulse and between pulses has been modelled using finite element methods to check the resistance of the dump at high repetition rates. In addition, the possibility of using a moveable dump to measure the beam profile and emittance is discussed.

  5. Sonablate-500TM Transrectal High-intensity Focused Ultrasound (HIFU) for Benign Prostatic Hyperplasia Patients

    Institute of Scientific and Technical Information of China (English)

    L(U) Jun; HU Weilie; WANG Wei; ZHANG Yuanfeng; CHEN Zhaoyang; YE Zhangqun

    2007-01-01

    To evaluate the safety and efficacy of transrectal high-intensity focused ultrasound (HIFU) in the treatment of benign prostatic hyperplasia (BPH), serial studies were conducted in 150 BPH pa- tients before and 30 min, 1, 2, 6 and 12 month(s) after Sonablate-500TM HIFU treatment. A sili- con-coated indwelling 16F latex catheter was placed during the determination of the therapy zone. Preoperative and postoperative evaluations were made by using the international prostate symptom score (IPSS), quality of life (QOL), uroflowmetric findings and transrectal ultrasound, and incidence of complications. The cystourethrography was done in 23 patients within 1 year postoperatively. The results showed that after HIFU treatment, IPSS and QOL scores were significantly decreased at 1, 2, 6 and 12 month(s) (P<0.01). Maximum urine flow rate (6.0 to 17.2 mL/s, P<0.01), PVR (75.0 to 30.3,P<0.01) and prostatic volume (65.0 to 38.1 mL, P<0.05) were significantly improved 12 months after the operation. Recurrent urinary retention (n=2) and urethrorectal fistula (n=1) occurred at the 15th postoperative day. The duration of the HIFU prostate ablation was 25-90 rain. The mean time for an indwelling catheter was 3-19 days. These data demonstrate that treatment of BPH with Sonab- late-500TM HIFU is safe and effective.

  6. Preoperative high-intensity training in frail old patients undergoing pulmonary resection for NSCLC.

    Science.gov (United States)

    Salvi, Rosario; Meoli, Ilernando; Cennamo, Antonio; Perrotta, Fabio; Saverio Cerqua, Francesco; Montesano, Raffaele; Curcio, Carlo; Lassandro, Francesco; Stefanelli, Francesco; Grella, Edoardo; Tafuri, Domenico; Mazzarella, Gennaro; Bianco, Andrea

    2016-01-01

    Thoracic surgery remains the better therapeutic option for non-small cell lung cancer patients that are diagnosed in early stage disease. Preoperative lung function assessment includes respiratory function tests (RFT) and cardio-pulmonary exercise testing (CPET). Vo2 peak, FEV1 and DLCO as well as recognition of performance status, presence of co-morbidities, frailty indexes, and age predict the potential impact of surgical resection on patient health status and survival risk. In this study we have retrospectively assessed the benefit of a high-intensity preoperative pulmonary rehabilitation program (PRP) in 14 patients with underlying lung function impairment prior to surgery. Amongst these, three patients candidate to surgical resection exhibited severe functional impairment associated with high score of frailty according CHS and SOF index, resulting in a substantial mortality risk. Our observations indicate that PRP appear to reduce the mortality and morbidity risk in frail patients with concurrent lung function impairment undergoing thoracic surgery. PRP produced improvement of VO2 peak degree and pulmonary function resulting in reduced postoperative complications in high-risk patients from our cases. Our results indicate that a preoperative training program may improve postoperative clinical outcomes in fraillung cancer patients with impaired lung function prior to surgical resection.

  7. Effect of high-intensity intermittent exercise on postprandial plasma triacylglycerol in sedentary young women.

    Science.gov (United States)

    Tan, Martin; Chan Moy Fat, Rachel; Boutcher, Yati N; Boutcher, Stephen H

    2014-02-01

    High-intensity intermittent exercise (HIIE) such as the 30-s Wingate test attenuates postprandial triacylglycerol (TG), however, the ability of shorter versions of HIIE to reduce postprandial TG is undetermined. Thus, the effect of 8-s sprinting bouts of HIIE on blood TG levels of 12 females after consumption of a high-fat meal (HFM) was examined. Twelve young, sedentary women (BMI 25.1 ± 2.3 kg/m²; age 21.3 ± 2.1 years) completed a maximal oxygen uptake test and then on different days underwent either an exercise or a no-exercise postprandial TG condition. Both conditions involved consuming a HFM after a 12-hr fast. The HFM, in milkshake form provided 4170 kJ (993 Kcal) of energy and 98 g fat. Order was counter-balanced. In the exercise condition participants completed 20-min of HIIE cycling consisting of repeated bouts of 8 s sprint cycling (100-115 rpm) and 12 s of active rest (easy pedaling) 14 hr before consuming the HFM. Blood samples were collected hourly after the HFM for 4 hr. Total postprandial TG was 13% lower, p = .004, in the exercise (5.84 ± 1.08 mmol L⁻¹ 4 h⁻¹) compared with the no-exercise condition (6.71 ± 1.63 mmol L⁻¹ 4 h⁻¹). In conclusion, HIIE significantly attenuated postprandial TG in sedentary young women.

  8. Is High-Intensity Functional Training (HIFT)/CrossFit Safe for Military Fitness Training?

    Science.gov (United States)

    Poston, Walker S C; Haddock, Christopher K; Heinrich, Katie M; Jahnke, Sara A; Jitnarin, Nattinee; Batchelor, David B

    2016-07-01

    High-intensity functional training (HIFT) is a promising fitness paradigm that gained popularity among military populations. Rather than biasing workouts toward maximizing fitness domains such as aerobic endurance, HIFT workouts are designed to promote general physical preparedness. HIFT programs have proliferated as a result of concerns about the relevance of traditional physical training (PT), which historically focused on aerobic condition via running. Other concerns about traditional PT include: (1) the relevance of service fitness tests given current combat demands, (2) the perception that military PT is geared toward passing service fitness tests, and (3) that training for combat requires more than just aerobic endurance. Despite its' popularity in the military, concerns have been raised about HIFT's injury potential, leading to some approaches being labeled as "extreme conditioning programs" by several military and civilian experts. Given HIFT programs' popularity in the military and concerns about injury, a review of data on HIFT injury potential is needed to inform military policy. The purpose of this review is to: (1) provide an overview of scientific methods used to appropriately compare injury rates among fitness activities and (2) evaluate scientific data regarding HIFT injury risk compared to traditional military PT and other accepted fitness activities.

  9. Propagation of Sound at Moderate and High Intensities in Absorbent and Hard-Walled Cylindrical Ducts. Ph.D. Thesis

    Science.gov (United States)

    Mcdaniel, Oliver Herbert

    1975-01-01

    The propagation of plane wave and higher order acoustic modes in both hard-walled and absorbent cylindrical ducts was studied at moderate sound intensities where the linear wave equation is valid, and at high intensities where nonlinear effects can be observed. The experiments were conducted with an anechoically terminated twelve-inch inside-diameter transite pipe. Various types of sound sources were mounted at one end of the duct to generate the desired acoustic fields within the duct. Arrays of conventional loudspeakers were used to generate plane waves and higher order acoustic modes at moderate intensities, and an array of four high intensity electro-pneumatic sound sources was used for the experiments in the nonlinear region. The attenuation of absorbent liners made of several different materials was obtained at moderate intensities for both plane waves and high order modes. It was found that the characteristics of the liners studied did not change appreciably at high intensities.

  10. Is There a Progressive Withdrawal of Physiological Protections against High-Intensity Exercise-Induced Fatigue during Puberty?

    Directory of Open Access Journals (Sweden)

    Sébastien Ratel

    2015-12-01

    Full Text Available Puberty is characterized by a large number of physiological modifications that translate into increased neuromuscular fatigue during high-intensity exercise in adolescents compared to prepubertal children. This greater neuromuscular fatigue in adolescents could be attributed to peripheral (i.e., muscular and central (i.e., nervous factors that change through puberty. Among the peripheral changes are muscle mass, fiber type composition, energy metabolism and musculo-tendinous stiffness. Among the central modifications are the voluntary activation level, the antagonist co-activation and a differential interplay between central and peripheral fatigue. The objective of this review article will be to underline the importance of these factors on the development of neuromuscular fatigue during high-intensity exercise throughout puberty and to highlight that the adolescents could be physiologically less protected against fatiguing high-intensity exercise than their prepubertal counterparts.

  11. Effects of high-intensity training and resumed training on macroelement and microelement of elite basketball athletes.

    Science.gov (United States)

    Wang, Lijuan; Zhang, Jun; Wang, Jiahong; He, Wangxiao; Huang, Hongen

    2012-11-01

    The purpose of this study was to assess the effects of high-intensity training and resumed training in hot and humid environment on plasma macro- and microelements levels of elite Han Chinese basketball players. Ten well-trained elite basketball athletes' plasma macroelements (chlorin, sodium, potassium, and calcium), creatine kinase (CK), and creatine kinase-MB (CK-MB) were measured before and after a 2-h high-intensity training, and microelements (zinc, copper, iron, and selenium) were determined before and after a 1-week high-intensity training and after a 1-week resumed training. The blood CK and CK-MB levels of the elite basketball athletes were significantly increased (P 0.05) were found in zinc and copper levels; nevertheless, the levels of plasma selenium and plasma iron were significantly lower (P iron.

  12. Enhancing gas-phase reaction in a plasma using high intensity and high power ultrasonic acoustic waves

    DEFF Research Database (Denmark)

    2010-01-01

    substantially 100 W. In this way, a high sound intensity and power are obtained that efficiently enhances a gas-phase reaction in the plasma, which enhances the plasma process, e.g. enabling more efficient ozone or hydrogen generation using plasma in relation to reaction speed and/or obtained concentration......This invention relates to enhancing a gas-phase reaction in a plasma comprising: creating plasma (104) by at least one plasma source (106), and wherein that the method further comprises: generating ultrasonic high intensity and high power acoustic waves (102) having a predetermined amount...... of acoustic energy by at least one ultrasonic high intensity and high power gas-jet acoustic wave generator (101), where said ultrasonic high intensity and high power acoustic waves are directed to propagate towards said plasma (104) so that at least a part of said predetermined amount of acoustic energy...

  13. Accelerating Value Creation with Accelerators

    DEFF Research Database (Denmark)

    Jonsson, Eythor Ivar

    2015-01-01

    accelerator programs. Microsoft runs accelerators in seven different countries. Accelerators have grown out of the infancy stage and are now an accepted approach to develop new ventures based on cutting-edge technology like the internet of things, mobile technology, big data and virtual reality. It is also...... with the traditional audit and legal universes and industries are examples of emerging potentials both from a research and business point of view to exploit and explore further. The accelerator approach may therefore be an Idea Watch to consider, no matter which industry you are in, because in essence accelerators...

  14. Longitudinal study of high intensity zones on MR of lumbar intervertebral discs

    Energy Technology Data Exchange (ETDEWEB)

    Mitra, D. E-mail: dipayan.mitra@nuth.northy.nhs.uk; Cassar-Pullicino, V.N.; McCall, I.W

    2004-11-01

    AIM: To study the temporal evolution of high intensity zones (HIZ) on MRI in patients with degenerative disease of the lumbar spine, and to evaluate whether any correlation exist between such evolution and in patient's symptoms. MATERIALS AND METHODS: HIZs in the MRI of 56 patients were included in the study. Each Patient had an initial and a follow-up scan performed at various time intervals. Scans were assessed for any change in HIZs by two observers (D. M. and I. W. M.). Patients' symptoms were assessed for by visual analogue score (VAS), the Oswestry Questionnaire Score (OQS) and patients' subjective assessment of change in symptoms. Any MRI feature, apart from HIZs, which could independently explain a patient's change in symptoms, was considered to be a confounding factor. Data were analysed separately in the whole group as well as in the group without confounding factors. RESULTS: On follow-up MRI, HIZs were found to have resolved in 17 lumbar disc levels (26.6%), improved in 9 (14%), worsened in 12 (18.8%) and remained unchanged in 26 (40.6%) at lumbar disc levels. Chi-square testing did not demonstrate any correlation between HIZ changes and evolution of patients' subjective symptoms (p=0.26 for the whole group; p=0.07 for the group without confounding factors). Similar lack of meaningful relationship was noted between HIZ changes and the VAS and OQS scores. CONCLUSION: We conclude that HIZs either do not change or improve spontaneously in a large proportion of cases over a period of time. Furthermore, there is no statistical correlation between HIZ changes and change in a patient's symptoms.

  15. Production of high intensity {sup 48}Ca for the 88-Inch Cyclotron and other updates

    Energy Technology Data Exchange (ETDEWEB)

    Benitez, J. Y.; Hodgkinson, A.; Lyneis, C. M., E-mail: jybenitez@lbl.gov; Strohmeier, M.; Thullier, T.; Todd, D.; Xie, D. [Nuclear Science Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720 (United States); Franzen, K. Y. [Mevion Medical Systems, 300 Foster St., Littleton, Massachusetts 01460 (United States)

    2014-02-15

    Recently the Versatile ECR for NUclear Science (VENUS) ion source was engaged in a 60-day long campaign to deliver high intensity {sup 48}Ca{sup 11+} beam to the 88-Inch Cyclotron. As the first long term use of VENUS for multi-week heavy-element research, new methods were developed to maximize oven to target efficiency. First, the tuning parameters of VENUS for injection into the cyclotron proved to be very different than those used to tune VENUS for maximum beam output of the desired charge state immediately following its bending magnet. Second, helium with no oxygen support gas was used to maximize the efficiency. The performance of VENUS and its low temperature oven used to produce the stable requested 75 eμA of {sup 48}Ca{sup 11+} beam current was impressive. The consumption of {sup 48}Ca in VENUS using the low temperature oven was checked roughly weekly, and was found to be on average 0.27 mg/h with an ionization efficiency into the 11+ charge state of 5.0%. No degradation in performance was noted over time. In addition, with the successful operation of VENUS the 88-Inch cyclotron was able to extract a record 2 pμA of {sup 48}Ca{sup 11+}, with a VENUS output beam current of 219 eμA. The paper describes the characteristics of the VENUS tune used for maximum transport efficiency into the cyclotron as well as ongoing efforts to improve the transport efficiency from VENUS into the cyclotron. In addition, we briefly present details regarding the recent successful repair of the cryostat vacuum system.

  16. Continuous Exercise but Not High Intensity Interval Training Improves Fat Distribution in Overweight Adults

    Directory of Open Access Journals (Sweden)

    Shelley E. Keating

    2014-01-01

    Full Text Available Objective. The purpose of this study was to assess the effect of high intensity interval training (HIIT versus continuous aerobic exercise training (CONT or placebo (PLA on body composition by randomized controlled design. Methods. Work capacity and body composition (dual-energy X-ray absorptiometry were measured before and after 12 weeks of intervention in 38 previously inactive overweight adults. Results. There was a significant group × time interaction for change in work capacity (P<0.001, which increased significantly in CONT (23.8±3.0% and HIIT (22.3±3.5% but not PLA (3.1±5.0%. There was a near-significant main effect for percentage trunk fat, with trunk fat reducing in CONT by 3.1±1.6% and in PLA by 1.1±0.4%, but not in HIIT (increase of 0.7±1.0% (P=0.07. There was a significant reduction in android fat percentage in CONT (2.7±1.3% and PLA (1.4±0.8% but not HIIT (increase of 0.8±0.7% (P=0.04. Conclusion. These data suggest that HIIT may be advocated as a time-efficient strategy for eliciting comparable fitness benefits to traditional continuous exercise in inactive, overweight adults. However, in this population HIIT does not confer the same benefit to body fat levels as continuous exercise training.

  17. Personalised Prescription of Scalable High Intensity Interval Training to Inactive Female Adults of Different Ages.

    Directory of Open Access Journals (Sweden)

    Jacqueline L Mair

    Full Text Available Stepping is a convenient form of scalable high-intensity interval training (HIIT that may lead to health benefits. However, the accurate personalised prescription of stepping is hampered by a lack of evidence on optimal stepping cadences and step heights for various populations. This study examined the acute physiological responses to stepping exercise at various heights and cadences in young (n = 14 and middle-aged (n = 14 females in order to develop an equation that facilitates prescription of stepping at targeted intensities. Participants completed a step test protocol consisting of randomised three-minute bouts at different step cadences (80, 90, 100, 110 steps·min-1 and step heights (17, 25, 30, 34 cm. Aerobic demand and heart rate values were measured throughout. Resting metabolic rate was measured in order to develop female specific metabolic equivalents (METs for stepping. Results revealed significant differences between age groups for METs and heart rate reserve, and within-group differences for METs, heart rate, and metabolic cost, at different step heights and cadences. At a given step height and cadence, middle-aged females were required to work at an intensity on average 1.9 ± 0.26 METs greater than the younger females. A prescriptive equation was developed to assess energy cost in METs using multilevel regression analysis with factors of step height, step cadence and age. Considering recent evidence supporting accumulated bouts of HIIT exercise for health benefits, this equation, which allows HIIT to be personally prescribed to inactive and sedentary women, has potential impact as a public health exercise prescription tool.

  18. High-intensity intermittent exercise and its effects on heart rate variability and subsequent strength performance

    Directory of Open Access Journals (Sweden)

    Valéria Leme Gonçalves Panissa

    2016-03-01

    Full Text Available PRUPOSE: To investigate the effects of a 5-km high-intensity interval exercise (HIIE on heart rate variability (HRV and subsequent strength performance. METHODS: nine trained males performed a control session composed of a half-squat strength exercise (4 x 80% of one repetition maximum – 1RM in isolation and 30-min, 1-, 4-, 8- and 24-h after an HIIE (1-min at the velocity peak:1-min passive recovery. All experimental sessions were performed on different days. The maximum number of repetitions and total weight lifted during the strength exercise were registered in all conditions; in addition, prior to each session, HRV were assessed [beat-to-beat intervals (RR and log-transformed of root means square of successive differences in the normal-to-normal intervals (lnRMSSD]. RESULTS: Performance in the strength exercise dropped at 30-min (31% and 1-h (19% post-HIIE concomitantly with lower values of RR (781±79 ms; 799±134 ms, respectively in the same recovery intervals compared to the control (1015±197 ms. Inferential analysis did not detect any effect of condition on lnRMSSD, however, values were lower after 30-min (3.5±0.4 ms and 1-h (3.3±0.5 ms with moderate and large effect sizes (0.9 and 1.2, respectively compared with the control condition (3.9±0.4 ms. CONCLUSION: Both RR and lnRMSSD seem to be associated with deleterious effects on strength performance, although further studies should be conducted to clarify this association.

  19. Changes of colour and carotenoids contents during high intensity pulsed electric field treatment in orange juices.

    Science.gov (United States)

    Cortés, C; Esteve, M J; Rodrigo, D; Torregrosa, F; Frígola, A

    2006-11-01

    Liquid chromatography (LC) was the method chosen to evaluate the effects of high intensity pulsed electric fields (HIPEF), with different electric field intensities (25, 30, 35 and 40 kV/cm) and different treatment times (30-340 micros), on orange juice cis/trans carotenoid contents. In parallel, a conventional heat treatment (90 degrees C, 20 s) was applied to the orange juice in order to compare the effect on the carotenoid contents. HIPEF processing of orange juice is an alternative to the thermal treatment of pasteurization, provided that it is kept refrigerated, because, when the most extreme conditions of this kind of treatment are applied, the decrease in the concentration of carotenoids with vitamin A activity is very small, and also most of the carotenoids identified have a slightly increased concentration after application of the most intense treatments, although always less than in untreated fresh juice. In any case, pasteurization treatment causes a greater decrease in the concentration of most of the carotenoids identified and the carotenoids with vitamin A activity. The total carotenoid concentration decreased by 12.6% in pasteurized orange juice with respect to untreated fresh orange juice, as opposed to decreases of 9.6%, 6.3% or 7.8% when fields of 25, 30 or 40 kV/cm were applied. Orange juice treated with HIPEF shows a greater tendency towards the colour yellow and a lesser tendency towards red with respect to untreated orange juice, while the luminance of the juice remains practically invariable. This tendency is less than in pasteurized orange juice.

  20. Inactivation of Saccharomyces cerevisiae suspended in orange juice using high-intensity pulsed electric fields.

    Science.gov (United States)

    Elez-Martínez, Pedro; Escolà-Hernández, Joan; Soliva-Fortuny, Robert C; Martín-Belloso, Olga

    2004-11-01

    Saccharomyces cerevisiae is often associated with the spoilage of fruit juices. The purpose of this study was to evaluate the effect of high-intensity pulsed electric field (HIPEF) treatment on the survival of S. cerevisiae suspended in orange juice. Commercial heat-sterilized orange juice was inoculated with S. cerevisiae (CECT 1319) (10(8) CFU/ml) and then treated by HIPEFs. The effects of HIPEF parameters (electric field strength, treatment time, pulse polarity, frequency, and pulse width) were evaluated and compared to those of heat pasteurization (90 degrees C/min). In all of the HIPEF experiments, the temperature was kept below 39 degrees C. S. cerevisiae cell damage induced by HIPEF treatment was observed by electron microscopy. HIPEF treatment was effective for the inactivation of S. cerevisiae in orange juice at pasteurization levels. A maximum inactivation of a 5.1-log (CFU per milliliter) reduction was achieved after exposure of S. cerevisiae to HIPEFs for 1,000 micros (4-micros pulse width) at 35 kV/cm and 200 Hz in bipolar mode. Inactivation increased as both the field strength and treatment time increased. For the same electric field strength and treatment time, inactivation decreased when the frequency and pulse width were increased. Electric pulses applied in the bipolar mode were more effective than those in the monopolar mode for destroying S. cerevisiae. HIPEF processing inactivated S. cerevisiae in orange juice, and the extent of inactivation was similar to that obtained during thermal pasteurization. HIPEF treatments caused membrane damage and had a profound effect on the intracellular organization of S. cerevisiae.

  1. Effects of oxytocin on high intensity focused ultrasound (HIFU) ablation of adenomysis: A prospective study

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Xin [State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Key laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016 (China); Zou, Min; Zhang, Cai [Department of Obstetrics and Gynecology, Chongqing Haifu Hospital, Chongqing 401121 (China); He, Jia [Department of Obstetrics and Gynecology, Suining Central Hospital, Sichuan 629000 (China); Mao, Shihua [Department of Obstetrics and Gynecology, Three Gorges Central Hospital, Chongqing 404000 (China); Wu, Qingrong [Department of Obstetrics and Gynecology, Fuling Central Hospital, Chongqing 408099 (China); He, Min [State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Key laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016 (China); Department of Obstetrics and Gynecology, Suining Central Hospital, Sichuan 629000 (China); Wang, Jian [Department of Obstetrics and Gynecology, Chongqing Haifu Hospital, Chongqing 401121 (China); Department of Obstetrics and Gynecology, Three Gorges Central Hospital, Chongqing 404000 (China); Zhang, Ruitao [Department of Obstetrics and Gynecology, Chongqing Haifu Hospital, Chongqing 401121 (China); Department of Obstetrics and Gynecology, Fuling Central Hospital, Chongqing 408099 (China); Zhang, Lian, E-mail: lianwzhang@yahoo.com [State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Key laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016 (China); Department of Obstetrics and Gynecology, Chongqing Haifu Hospital, Chongqing 401121 (China)

    2014-09-15

    Objective: To investigate the effects of oxytocin on high-intensity focused ultrasound (HIFU) ablation for the treatment of adenomyosis. Materials and methods: Eighty-six patients with adenomyosis from three hospitals were randomly assigned to the oxytocin group or control group for HIFU treatment. During HIFU treatment, 80 units of oxytocin was added in 500 ml of 0.9% normal saline running at the rate of 2 ml/min (0.32 U/min) in the oxytocin group, while 0.9% normal saline was used in the control group. Both patients and HIFU operators were blinded to oxytocin or saline application. Treatment results, adverse effects were compared. Results: When using oxytocin, the non-perfused volume (NPV) ratio was 80.7 ± 11.6%, the energy-efficiency factor (EEF) was 8.1 ± 9.9 J/mm{sup 3}, and the sonication time required to ablate 1 cm{sup 3} was 30.0 ± 36.0 s/cm{sup 3}. When not using oxytocin, the non-perfused volume ratio was 70.8 ± 16.7%, the EEF was 15.8 ± 19.6 J/mm{sup 3}, and the sonication time required to ablate 1 cm{sup 3} was 58.2 ± 72.7 S/cm{sup 3}. Significant difference in the NPV ratio, EEF, and the sonication time required to ablate 1 cm{sup 3} between the two groups was observed. No oxytocin related adverse effects occurred. Conclusion: Oxytocin could significantly decrease the energy for ablating adenomyosis with HIFU, safely enhance the treatment efficiency.

  2. Production of high intensity 48Ca for the 88-Inch Cyclotron and other updates

    Science.gov (United States)

    Benitez, J. Y.; Franzen, K. Y.; Hodgkinson, A.; Lyneis, C. M.; Strohmeier, M.; Thullier, T.; Todd, D.; Xie, D.

    2014-02-01

    Recently the Versatile ECR for NUclear Science (VENUS) ion source was engaged in a 60-day long campaign to deliver high intensity 48Ca11+ beam to the 88-Inch Cyclotron. As the first long term use of VENUS for multi-week heavy-element research, new methods were developed to maximize oven to target efficiency. First, the tuning parameters of VENUS for injection into the cyclotron proved to be very different than those used to tune VENUS for maximum beam output of the desired charge state immediately following its bending magnet. Second, helium with no oxygen support gas was used to maximize the efficiency. The performance of VENUS and its low temperature oven used to produce the stable requested 75 eμA of 48Ca11+ beam current was impressive. The consumption of 48Ca in VENUS using the low temperature oven was checked roughly weekly, and was found to be on average 0.27 mg/h with an ionization efficiency into the 11+ charge state of 5.0%. No degradation in performance was noted over time. In addition, with the successful operation of VENUS the 88-Inch cyclotron was able to extract a record 2 pμA of 48Ca11+, with a VENUS output beam current of 219 eμA. The paper describes the characteristics of the VENUS tune used for maximum transport efficiency into the cyclotron as well as ongoing efforts to improve the transport efficiency from VENUS into the cyclotron. In addition, we briefly present details regarding the recent successful repair of the cryostat vacuum system.

  3. Dynamics of corticospinal changes during and after high-intensity quadriceps exercise.

    Science.gov (United States)

    Gruet, Mathieu; Temesi, John; Rupp, Thomas; Levy, Patrick; Verges, Samuel; Millet, Guillaume Y

    2014-08-01

    This study tested the hypothesis that during fatiguing quadriceps exercise, supraspinal fatigue develops late, is associated with both increased corticospinal excitability and inhibition and recovers quickly. Eight subjects performed 20 s contractions [15 s at 50% maximal voluntary contraction (MVC) followed by 5 s MVC] separated by a 10 s rest period until task failure. Transcranial magnetic stimulation (TMS) and electrical femoral nerve stimulation (PNS) were delivered ∼ 2 s apart during 50% MVC, during MVC and after MVC in relaxed muscle. Voluntary activation was assessed by TMS (VATMS) immediately before and after exercise and then three times over a 6 min recovery period. During exercise, MVC and twitch force evoked by PNS in relaxed muscle decreased progressively to 48 ± 8 and 36 ± 16% of control values, respectively (both P MVC were observed during the last quarter of exercise only (from 96.4 ± 1.7 to 86 ± 13%, P = 0.03 and from 0.76 ± 0.8 to 4.9 ± 4.7% MVC, P = 0.02, from baseline to task failure, respectively). The TMS-induced silent period increased linearly during both MVC (by ∼ 79 ms) and 50% MVC (by ∼ 63 ms; both P MVC and twitch force evoked by PNS in relaxed muscle recovered to only 84 ± 9 and 73 ± 17% of control values 6 min after exercise, respectively. In conclusion, high-intensity single-joint quadriceps exercise induces supraspinal fatigue near task failure, with increased intracortical inhibition and, in contrast to previous upper-limb results, unchanged corticospinal excitability. These changes recover rapidly after task failure, emphasizing the need to measure corticospinal adaptations immediately at task failure to avoid underestimation of exercise-induced corticospinal changes.

  4. Quantitative ultrasound imaging for monitoring in situ high-intensity focused ultrasound exposure.

    Science.gov (United States)

    Ghoshal, Goutam; Kemmerer, Jeremy P; Karunakaran, Chandra; Abuhabsah, Rami; Miller, Rita J; Sarwate, Sandhya; Oelze, Michael L

    2014-10-01

    Quantitative ultrasound (QUS) imaging is hypothesized to map temperature elevations induced in tissue with high spatial and temporal resolution. To test this hypothesis, QUS techniques were examined to monitor high-intensity focused ultrasound (HIFU) exposure of tissue. In situ experiments were conducted on mammary adenocarcinoma tumors grown in rats and lesions were formed using a HIFU system. A thermocouple was inserted into the tumor to provide estimates of temperature at one location. Backscattered time-domain waveforms from the tissue during exposure were recorded using a clinical ultrasonic imaging system. Backscatter coefficients were estimated using a reference phantom technique. Two parameters were estimated from the backscatter coefficient (effective scatterer diameter (ESD) and effective acoustic concentration (EAC). The changes in the average parameters in the regions corresponding to the HIFU focus over time were correlated to the temperature readings from the thermocouple. The changes in the EAC parameter were consistently correlated to temperature during both heating and cooling of the tumors. The changes in the ESD did not have a consistent trend with temperature. The mean ESD and EAC before exposure were 120 ± 16 μm and 32 ± 3 dB/cm3, respectively, and changed to 144 ± 9 μm and 51 ± 7 dB/cm3, respectively, just before the last HIFU pulse was delivered to the tissue. After the tissue cooled down to 37 °C, the mean ESD and EAC were 126 ± 8 μm and 35 ± 4 dB/cm3, respectively. Peak temperature in the range of 50-60 °C was recorded by a thermocouple placed just behind the tumor. These results suggest that QUS techniques have the potential to be used for non-invasive monitoring of HIFU exposure.

  5. Modelling the temperature evolution of bone under high intensity focused ultrasound

    Science.gov (United States)

    ten Eikelder, H. M. M.; Bošnački, D.; Elevelt, A.; Donato, K.; Di Tullio, A.; Breuer, B. J. T.; van Wijk, J. H.; van Dijk, E. V. M.; Modena, D.; Yeo, S. Y.; Grüll, H.

    2016-02-01

    Magnetic resonance-guided high intensity focused ultrasound (MR-HIFU) has been clinically shown to be effective for palliative pain management in patients suffering from skeletal metastasis. The underlying mechanism is supposed to be periosteal denervation caused by ablative temperatures reached through ultrasound heating of the cortex. The challenge is exact temperature control during sonication as MR-based thermometry approaches for bone tissue are currently not available. Thus, in contrast to the MR-HIFU ablation of soft tissue, a thermometry feedback to the HIFU is lacking, and the treatment of bone metastasis is entirely based on temperature information acquired in the soft tissue adjacent to the bone surface. However, heating of the adjacent tissue depends on the exact sonication protocol and requires extensive modelling to estimate the actual temperature of the cortex. Here we develop a computational model to calculate the spatial temperature evolution in bone and the adjacent tissue during sonication. First, a ray-tracing technique is used to compute the heat production in each spatial point serving as a source term for the second part, where the actual temperature is calculated as a function of space and time by solving the Pennes bio-heat equation. Importantly, our model includes shear waves that arise at the bone interface as well as all geometrical considerations of transducer and bone geometry. The model was compared with a theoretical approach based on the far field approximation and an MR-HIFU experiment using a bone phantom. Furthermore, we investigated the contribution of shear waves to the heat production and resulting temperatures in bone. The temperature evolution predicted by our model was in accordance with the far field approximation and agreed well with the experimental data obtained in phantoms. Our model allows the simulation of the HIFU treatments of bone metastasis in patients and can be extended to a planning tool prior to MR

  6. An electron of helium atom under a high-intensity laser field

    Science.gov (United States)

    Falaye, Babatunde James; Sun, Guo-Hua; Adepoju, Adenike Grace; Liman, Muhammed S.; Oyewumi, K. J.; Dong, Shi-Hai

    2017-02-01

    We scrutinize the behavior of eigenvalues of an electron in a helium (He) atom as it interacts with electric field directed along the z-axis and is exposed to linearly polarized intense laser field radiation. To achieve this, we freeze one electron of the He atom at its ionic ground state and the motion of the second electron in the ion core is treated via a more general case of screened Coulomb potential model. Using the Kramers-Henneberger (KH) unitary transformation, which is the semiclassical counterpart of the Block-Nordsieck transformation in the quantized field formalism, the squared vector potential that appears in the equation of motion is eliminated and the resultant equation is expressed in the KH frame. Within this frame, the resulting potential and the corresponding wave function are expanded in Fourier series and using Ehlotzky’s approximation, we obtain a laser-dressed potential to simulate intense laser field. By fitting the more general case of screened Coulomb potential model into the laser-dressed potential, and then expanding it in Taylor series up to O≤ft({{r}4},α 09\\right) , we obtain the solution (eigenvalues and wave function) of an electron in a He atom under the influence of external electric field and high-intensity laser field, within the framework of perturbation theory formalism. We found that the variation in frequency of laser radiation has no effect on the eigenvalues of a He electron for a particular electric field intensity directed along z-axis. Also, for a very strong external electric field and an infinitesimal screening parameter, the system is strongly bound. This work has potential application in the areas of atomic and molecular processes in external fields including interactions with strong fields and short pulses.

  7. The Metabolic Cost of a High Intensity Exercise Program During Bed Rest

    Science.gov (United States)

    Hackney, Kyle; Everett, Meghan; Guined, Jamie; Cunningham, Daid

    2012-01-01

    Background: Given that disuse-related skeletal muscle atrophy may be exacerbated by an imbalance between energy intake and output, the amount of energy required to complete exercise countermeasures is an important consideration in the well being of subject health during bed rest and spaceflight. Objective: To evaluate the energy cost of a high intensity exercise program performed during short duration bed rest. Methods: 9 subjects (8 male and 1 female; 34.5 +/- 8.2 years) underwent 14 days of bed rest and exercise countermeasures. Exercise energy expenditure and excess post exercise oxygen consumption (EPOC) were collected once in each of 5 different exercise protocols (30 second, 2 minute and 4 minute intervals, continuous aerobic and a variety of resistance exercises) during bed rest. Body mass, basal metabolic rate (BMR), upper and lower leg muscle, subcutaneous, and intramuscular adipose tissue (IMAT) volumes were assessed before and at the end of bed rest. Results: There were no significant differences in body mass (pre: 75.1 +/- 10.5 kg; post: 75.2 +/- 10.1 kg), BMR (pre: 1649 +/- 216 kcal; post: 1657 +/- 177 kcal), muscle subcutaneous, or IMAT volumes (Table 2) after 14 days of bed rest and exercise. Body mass was maintained with an average daily intake of 2710 +/- 262 kcal (36.2 +/- 2.1 kcal/kg/day), while average daily energy expenditure was 2579 +/-311 kcal (34.5 +/- 3.6 kcal/kg/day). Exercise energy expenditure was significantly greater as a result of continuous aerobic exercise than all other exercise protocols.

  8. Long Rest Interval Promotes Durable Testosterone Responses in High-Intensity Bench Press.

    Science.gov (United States)

    Scudese, Estevão; Simão, Roberto; Senna, Gilmar; Vingren, Jakob L; Willardson, Jeffrey M; Baffi, Matheus; Miranda, Humberto

    2016-05-01

    The purpose of this study was to examine the influence of rest period duration (1 vs. 3 minute between sets) on acute hormone responses to a high-intensity and equal volume bench press workout. Ten resistance-trained men (25.2 ± 5.6 years; 78.2 ± 5.7 kg; 176.7 ± 5.4 cm; bench press relative strength: 1.3 ± 0.1 kg per kilogram of body mass) performed 2 bench press workouts separated by 1 week. Each workout consisted of 5 sets of 3 repetitions performed at 85% of 1 repetition maximum, with either 1- or 3-minute rest between sets. Circulating concentrations of total testosterone (TT), free testosterone (FT), cortisol (C), testosterone/cortisol ratio (TT/C), and growth hormone (GH) were measured at preworkout (PRE), and immediately (T0), 15 minutes (T15), and 30 minutes (T30) postworkout. Rating of perceived exertion was recorded before and after each set. For TT, both rest lengths enhanced all postexercise verifications (T0, T15, and T30) compared with PRE, with 1 minute showing decreases on T15 and T30 compared with T0. For FT, both 1- and 3-minute rest protocols triggered augmentations on distinct postexercise moments (T0 and T15 for 1 minute; T15 and T30 for 3-minute) compared with PRE. The C values did not change throughout any postexercise verification for either rests. The TT/C ratio was significantly elevated for both rests in all postexercise moments compared with PRE. Finally, GH values did not change for both rest lengths. In conclusion, although both short and long rest periods enhanced acute testosterone values, the longer rest promoted a long-lasting elevation for both TT and FT.

  9. Conceptual design of a high-intensity positron source for the Advanced Neutron Source

    Energy Technology Data Exchange (ETDEWEB)

    Hulett, L.D.; Eberle, C.C.

    1994-12-01

    The Advanced Neutron Source (ANS) is a planned new basic and applied research facility based on a powerful steady-state research reactor that provides neutrons for measurements and experiments in the fields of materials science and engineering, biology, chemistry, materials analysis, and nuclear science. The useful neutron flux will be at least five times more than is available in the world`s best existing reactor facility. Construction of the ANS provides a unique opportunity to build a positron spectroscopy facility (PSF) with very-high-intensity beams based on the radioactive decay of a positron-generating isotope. The estimated maximum beam current is 1000 to 5000 times higher than that available at the world`s best existing positron research facility. Such an improvement in beam capability, coupled with complementary detectors, will reduce experiment durations from months to less than one hour while simultaneously improving output resolution. This facility will remove the existing barriers to the routine use of positron-based analytical techniques and will be a giant step toward realization of the full potential of the application of positron spectroscopy to materials science. The ANS PSF is based on a batch cycle process using {sup 64}Cu isotope as the positron emitter and represents the status of the design at the end of last year. Recent work not included in this report, has led to a proposal for placing the laboratory space for the positron experiments outside the ANS containment; however, the design of the positron source is not changed by that relocation. Hydraulic and pneumatic flight tubes transport the source material between the reactor and the positron source where the beam is generated and conditioned. The beam is then transported through a beam pipe to one of several available detectors. The design presented here includes all systems necessary to support the positron source, but the beam pipe and detectors have not been addressed yet.

  10. Modeling of high-intensity focused ultrasound-induced lesions in the presence of cavitation bubbles

    Science.gov (United States)

    Chavrier; Chapelon; Gelet; Cathignol

    2000-07-01

    The classical "Bio Heat Transfer Equation (BHTE)" model is adapted to take into account the effects of oscillating microbubbles that occur naturally in the tissue during high-intensity focused ultrasound (HIFU) treatment. First, the Gilmore-Akulichev model is used to quantify the acoustic pressure scattered by microbubbles submitted to HIFU. Because this scattered pressure is not monochromatic, the concept of harmonic attenuation is introduced and a global attenuation coefficient is estimated for bubble-filled tissues. The first results show that this global attenuation coefficient varies significantly with respect to several parameters such as the frequency and the density of microbubbles in the medium, but also with respect to the incident acoustic pressure which thus becomes a transcendental function. Under these conditions, a layer-by-layer modeling, in the direction of propagation, is proposed to calculate the ultrasonic beam. Finally, the BHTE is solved and the HIFU-induced lesions are estimated by the calculation of the thermal dose. Using this model, it can be observed first that, when the firing power increases, the lesion develops clearly in the direction of the transducer, with a shape agreeing with in vivo experimentation. Next, it is observed that the lesion can be significantly modified in size and position, if an interface (skin or inner wall) is simulated as a zone with multiple cavitation nuclei. With a firing power increase, it is also shown how a secondary lesion can appear at the interface and how, beyond a certain threshold, this lesion develops at the main lesion expense. Finally, a better in-depth homogeneity of lesions is observed when the acoustic frequency of HIFU is increased.

  11. Long term effects of high intensity laser therapy in lateral epicondylitis patients.

    Science.gov (United States)

    Akkurt, Ekrem; Kucuksen, Sami; Yılmaz, Halim; Parlak, Selman; Sallı, Ali; Karaca, Gülten

    2016-02-01

    The objective of this study is to investigate short- and long-term effects of high-intensity laser therapy (HILT) in lateral epicondylitis (LE) patients. Thirty patients with LE diagnosis (23 unilateral and 7 bilateral in total 37 elbows) were treated using HILT. LE patients were evaluated before, right after, and 6 months following HILT intervention post-treatment using visual analogue scale for pain (VAS) during activity and resting. Disabilities of the Arm, Shoulder, and Hand (DASH) Score and hand grip strength test (HGST) were used. The participants of the present study were also evaluated using Short-Form 36 (SF-36) before and 6 months after the treatment. Out of the 30 patients, 8 were male and 22 female with a mean age of 47.2 ± 9.7. The activity and resting VAS, DASH, and HGST scores revealed statistically significant improvement (p = 0.001) following treatment. Whereas VAS activity, DASH, and HGST scores increased after treatment until post-treatment 6 months significantly (p = 0.001), VAS resting scores remained stable (p = 0.476). A statistically significant improvement was also evident in the physical and mental components of SF-36 scores following treatment until post-treatment 6 months compared to pre-treatment scores (p = 0.001). In conclusion, the results of the present study suggest that HILT is a reliable, safe, and effective treatment option in LE patients in the short and long term considering pain, functional status, and quality of life.

  12. Pressure pain mapping of the wrist extensors after repeated eccentric exercise at high intensity.

    Science.gov (United States)

    Delfa de la Morena, José M; Samani, Afshin; Fernández-Carnero, Josué; Hansen, Ernst A; Madeleine, Pascal

    2013-11-01

    The purpose of this study was to investigate adaptation mechanisms after 2 test rounds consisting of eccentric exercise using pressure pain imaging of the wrist extensors. Pressure pain thresholds (PPTs) were assessed over 12 points forming a 3 × 4 matrix over the dominant elbow in 12 participants. From the PPT assessments, pressure pain maps were computed. Delayed onset muscle soreness was induced in an initial test round of high-intensity eccentric exercise. The second test round performed 7 days later aimed at resulting in adaptation. The PPTs were assessed before, immediately after, and 24 hours after the 2 test rounds of eccentric exercise. For the first test round, the mean PPT was significantly lower 24 hours after exercise compared with before exercise (389.5 ± 64.1 vs. 500.5 ± 66.4 kPa, respectively; p = 0.02). For the second test round, the PPT was similar before and 24 hours after (447.7 ± 51.3 vs. 458.0 ± 73.1 kPa, respectively; p = 1.0). This study demonstrated adaptive effects of the wrist extensors monitored by pain imaging technique in healthy untrained humans. A lack of hyperalgesia, i.e., no decrease in PPT underlined adaptation after the second test round of eccentric exercise performed 7 days after the initial test round. The present findings showed for the first time that repeated eccentric exercise performed twice over 2 weeks protects the wrist extensor muscles from developing exacerbated pressure pain sensitivity. Thus, the addition of eccentric components to training regimens should be considered to induce protective adaptation.

  13. High-Intensity Inspiratory Protocol Increases Heart Rate Variability in Myocardial Revascularization Patients

    Directory of Open Access Journals (Sweden)

    Flavia Cristina Rossi Caruso

    2016-02-01

    Full Text Available Abstract Objective: To evaluate heart rate variability during an inspiratory muscle endurance protocol at three different load levels [30%, 60% and 80% of maximal inspiratory pressure], in patients who had previously undergone coronary artery bypass grafting. Methods: Nineteen late postoperative myocardial revascularization patients participating in a cardiovascular rehabilitation program were studied. Maximal inspiratory pressure maneuvers were performed. An inspiratory muscle endurance protocol at 30%, 60% and 80% of maximal inspiratory pressure was applied for four minutes each, in random order. Heart rate and RR intervals were recorded and heart rate variability was analyzed by time (RMSSD-the mean of the standard deviations for all R-R intervals, and RMSM-root-mean square differences of successive R-R intervals and frequency domains indices (high and low frequency in normalized units. ANOVA for repeated measurements was used to compare heart rate variability indices and Student t-test was used to compare the maximal inspiratory pressure and maximal expiratory pressure values. Results: Heart rate increased during performance of maximal respiratory pressures maneuvers, and the maximal inspiratory pressure and maximal expiratory pressure mean values were significantly lower than predicted values (P <0.05. RMSSD increased significantly at 80% in relation to rest and 30% of maximal inspiratory pressure and RMSM decreased at 30% and 60% of maximal inspiratory pressure in relation to rest (P <0.05. Additionally, there was significant and progressive decrease in low frequency and increase in high frequency at 30%, 60% and 80% of maximal inspiratory pressure in relation to the resting condition. Conclusion: These results suggest that respiratory muscle training at high intensities can promote greater parasympathetic activity and it may confer important benefits during a rehabilitation program in post-coronary artery bypass grafting.

  14. Modeling and Predicting Tissue Movement and Deformation for High Intensity Focused Ultrasound Therapy

    Science.gov (United States)

    Liao, Xiangyun; Yuan, Zhiyong; Lai, Qianfeng; Guo, Jiaxiang; Zheng, Qi; Yu, Sijiao; Tong, Qianqian; Si, Weixin; Sun, Mingui

    2015-01-01

    Purpose In ultrasound-guided High Intensity Focused Ultrasound (HIFU) therapy, the target tissue (such as a tumor) often moves and/or deforms in response to an external force. This problem creates difficulties in treating patients and can lead to the destruction of normal tissue. In order to solve this problem, we present a novel method to model and predict the movement and deformation of the target tissue during ultrasound-guided HIFU therapy. Methods Our method computationally predicts the position of the target tissue under external force. This prediction allows appropriate adjustments in the focal region during the application of HIFU so that the treatment head is kept aligned with the diseased tissue through the course of therapy. To accomplish this goal, we utilize the cow tissue as the experimental target tissue to collect spatial sequences of ultrasound images using the HIFU equipment. A Geodesic Localized Chan-Vese (GLCV) model is developed to segment the target tissue images. A 3D target tissue model is built based on the segmented results. A versatile particle framework is constructed based on Smoothed Particle Hydrodynamics (SPH) to model the movement and deformation of the target tissue. Further, an iterative parameter estimation algorithm is utilized to determine the essential parameters of the versatile particle framework. Finally, the versatile particle framework with the determined parameters is used to estimate the movement and deformation of the target tissue. Results To validate our method, we compare the predicted contours with the ground truth contours. We found that the lowest, highest and average Dice Similarity Coefficient (DSC) values between predicted and ground truth contours were, respectively, 0.9615, 0.9770 and 0.9697. Conclusion Our experimental result indicates that the proposed method can effectively predict the dynamic contours of the moving and deforming tissue during ultrasound-guided HIFU therapy. PMID:25993644

  15. Comparison of Square and Radial Geometries for High Intensity Laser Power Beaming Receivers

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    Raible, Daniel E.; Fast, Brian R.; Dinca, Dragos; Nayfeh, Taysir H.; Jalics, Andrew K.

    2012-01-01

    In an effort to further advance a realizable form of wireless power transmission (WPT), high intensity laser power beaming (HILPB) has been developed for both space and terrestrial applications. Unique optical-to-electrical receivers are employed with near infrared (IR-A) continuous-wave (CW) semiconductor lasers to experimentally investigate the HILPB system. In this paper, parasitic feedback, uneven illumination and the implications of receiver array geometries are considered and experimental hardware results for HILPB are presented. The TEM00 Gaussian energy profile of the laser beam presents a challenge to the effectiveness of the receiver to perform efficient photoelectric conversion, due to the resulting non-uniform illumination of the photovoltaic cell arrays. In this investigation, the geometry of the receiver is considered as a technique to tailor the receiver design to accommodate the Gaussian beam profile, and in doing so it is demonstrated that such a methodology is successful in generating bulk receiver output power levels reaching 25 W from 7.2 sq cm of photovoltaic cells. These results are scalable, and may be realized by implementing receiver arraying and utilizing higher power source lasers to achieve a 1.0 sq m receiver capable of generating over 30 kW of electrical power. This type of system would enable long range optical "refueling" of electric platforms, such as MUAV s, airships, robotic exploration missions and provide power to spacecraft platforms which may utilize it to drive electric means of propulsion. In addition, a smaller HILPB receiver aperture size could be utilized to establish a robust optical communications link within environments containing high levels of background radiance, to achieve high signal to noise ratios.

  16. VO2max trainability and high intensity interval training in humans: a meta-analysis.

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    Andrew P Bacon

    Full Text Available Endurance exercise training studies frequently show modest changes in VO2max with training and very limited responses in some subjects. By contrast, studies using interval training (IT or combined IT and continuous training (CT have reported mean increases in VO2max of up to ~1.0 L · min(-1. This raises questions about the role of exercise intensity and the trainability of VO2max. To address this topic we analyzed IT and IT/CT studies published in English from 1965-2012. Inclusion criteria were: 1≥ 3 healthy sedentary/recreationally active humans <45 yrs old, 2 training duration 6-13 weeks, 3 ≥ 3 days/week, 4 ≥ 10 minutes of high intensity work, 5 ≥ 1:1 work/rest ratio, and 6 results reported as mean ± SD or SE, ranges of change, or individual data. Due to heterogeneity (I(2 value of 70, statistical synthesis of the data used a random effects model. The summary statistic of interest was the change in VO2max. A total of 334 subjects (120 women from 37 studies were identified. Participants were grouped into 40 distinct training groups, so the unit of analysis was 40 rather than 37. An increase in VO2max of 0.51 L · min(-1 (95% CI: 0.43 to 0.60 L · min(-1 was observed. A subset of 9 studies, with 72 subjects, that featured longer intervals showed even larger (~0.8-0.9 L · min(-1 changes in VO2max with evidence of a marked response in all subjects. These results suggest that ideas about trainability and VO2max should be further evaluated with standardized IT or IT/CT training programs.

  17. Echocardiographic Evaluation of the Effects of High-Intensity Interval Training on Cardiac Morphology and Function

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    Saadatnia

    2016-02-01

    Full Text Available Background High-intensity interval training (HIIT is a time-efficient alternative to traditional prolonged training. In contrast to ample evidence describing the effects of prolonged training, there are few data describing cardiovascular adaptations arising from HIIT interventions. Objectives The present study aimed to evaluate the effects of HIIT on heart morphology and function in untrained male subjects. Patients and Methods Twenty-two young men (age = 23.34 ± 2.56 years, weight = 72.47 ± 12.01 kg, and height = 174.10 ± 5.75 cm were recruited and randomly assigned into control (n = 10 and HIIT (n = 12 groups. Echocardiography was used to evaluate left ventricular mass (LVM, end-systolic volume (ESV, end-diastolic volume (EDV, interventricular septal wall thickness (IVSWT, stroke volume, and ejection fraction (EF. Also, the Bruce treadmill test was employed to estimate VO2max. Results The HIIT subjects showed a significant increase in EDV (P = 0.001, LVM (P = 0.002, stroke volume (P = 0.003, and EF (P = 0.001. However, there was no change in ESV due to HIIT (P = 0.916. Additionally, following HIIT, IVSWT (P = 0.227, despite exhibiting a slight increase, was not significantly different from pre-training levels. Conclusions HIIT in previously untrained subjects led to a significant change in left ventricle (LV morphology, correlating with improvement in aerobic power (VO2max. Cardiac remodeling was characterized by an increased EDV and a similar increase in LVM.

  18. Autonomic Function Predicts Fitness Response to Short-Term High-Intensity Interval Training.

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    Kiviniemi, A M; Tulppo, M P; Eskelinen, J J; Savolainen, A M; Kapanen, J; Heinonen, I H A; Hautala, A J; Hannukainen, J C; Kalliokoski, K K

    2015-11-01

    We tested the hypothesis that baseline cardiac autonomic function and its acute response to all-out interval exercise explains individual fitness responses to high-intensity interval training (HIT). Healthy middle-aged sedentary men performed HIT (n=12, 4-6×30 s of all-out cycling efforts with 4-min recovery) or aerobic training (AET, n=9, 40-60 min at 60% of peak workload in exercise test [Loadpeak]), comprising 6 sessions within 2 weeks. Low (LF) and high frequency (HF) power of R-R interval oscillation were analyzed from data recorded at supine and standing position (5+5 min) every morning during the intervention. A significant training effect (ptraining*group interaction, was observed in Loadpeak and peak oxygen consumption (VO2peak). Pre-training supine LF/HF ratio, an estimate of sympathovagal balance, correlated with training outcome in Loadpeak (Spearman's rho [rs]=-0.74, p=0.006) and VO2peak (rs=- 0.59, p=0.042) in the HIT but not the AET group. Also, the mean change in the standing LF/HF ratio in the morning after an acute HIT exercise during the 1(st) week of intervention correlated with training response in Loadpeak (rs=- 0.68, p=0.014) and VO2peak (rs=-0.60, p=0.039) with HIT but not with AET. In conclusion, pre-training cardiac sympathovagal balance and its initial alterations in response to acute HIT exercise were related to fitness responses to short-term HIT.

  19. Aerobic and anaerobic changes with high-intensity interval training in active college-aged men.

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    Ziemann, Ewa; Grzywacz, Tomasz; Łuszczyk, Marcin; Laskowski, Radoslaw; Olek, Robert A; Gibson, Ann L

    2011-04-01

    We investigated the aerobic and anaerobic benefits of high-intensity interval training performed at a work-to-rest ratio of 1:2 because little performance enhancement data exist based on this ratio. Recreationally active male volunteers (21 years, 184 cm, 81.5 kg) were randomly assigned to a training (interval training [IT] n = 10) or control group (n = 11). Baseline assessments were repeated after the last training session. Each participant underwent basic anthropometric assessment and performed a VO2max test on an electronically braked cycle ergometer and a 30-second Wingate test. Venous samples were acquired at the antecubital vein and subsequently processed for lactate (LA); samples were obtained at rest, and 5 and 15-minute post-Wingate test. The interval training used a cycling power output equivalent to 80% of VO2max (80% p VO2max) applied for 6 90-second bouts (each followed by 180-second rest) per session, 3 sessions per week, for 6 weeks. The control group maintained their normal routine for the 6-week period. Group × time repeated-measures analyses of variance revealed that IT improved VO2max (5.5 ml · kg(-1) · min), anaerobic threshold (3.8 ml · kg(-1) · min), work output (12.5 J · kg(-1)), glycolytic work (11.5 J · kg(-1)), mean power (0.3 W · kg), peak power (0.4 W · kg(-1)), and max power (0.4 W · kg(-1)); p training program may rapidly restore or improve a client's or athlete's maximal functional capacity.

  20. THE EFFECTS OF A SHORT TERM HIGH-INTENSITY CIRCUIT TRAINING EXERCISE IN UNIVERSITY STUDENTS

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    Rie Takakura

    2015-08-01

    Full Text Available Background: Physical inactivity is one non-communicable disease threatening to become the fourth leading risk factor for global mortality. Japan is no exception especially in the younger population. The purpose of the study is to investigate the effect of high-intensity circuit exercise training (HICET in university students. The second purpose is to examine the factors influencing exercise adherence. Methods: This study was a home based experimental study with 65 healthy participants from the Osaka Kawasaki Rehabilitation University, Japan. An independent variable was the 7-minute HICET and a dependent variable was the physical fitness test (PFT results. All participants were instructed to perform once daily a cycle of HICET, 2-3 times a week non-consecutively for 8 weeks. Pre and post PFT scores for men and women were compared for the effectiveness of the program. A brief survey was conducted 8 weeks after the completion of the study. Results: Both groups showed improvement in sit-up, push-up, and 5-minute run after the 8 week HICET. The changes between pre and post scores were significant in all but the 5-minute run for women. Discontinuation rate 8 weeks after the study was higher in women than in men, but not statistically significant with no dropouts during intervention. Discussion: An 8 week home based HICET significantly improved strength for both genders and endurance for men of the university students when measured by PFT. The exercise barriers should be assessed and adapted to fit individual needs to improve adherence rate.

  1. Enhanced high intensity focused ultrasound heat deposition for more efficient hemostasis

    Science.gov (United States)

    Labuda, Cecille Pemberton

    High intensity focused ultrasound (HIFU) is currently being developed for hemorrhage control since it provides rapid energy deposition in the form of heat in the HIFU focal region. When the HIFU focus is targeted on soft tissue wounds, the resulting elevation of tissue temperature cauterizes the tissues thus stopping the bleeding. If HIFU is targeted near blood vessels with millimeter-range diameter, the rate of heat deposition is limited by loss of heat to the blood flow. Maximizing the local heat deposition is important for the achievement of HIFU-induced hemorrhage control, or "hemostasis", near large vessels. In this study, the effect of a fiber device on the heat deposition in the HIFU focal region is investigated in tissue-mimicking flow phantoms with liquid albumen as the heat-sensitive denaturing flow fluid. The effect of the embedded fiber on albumen coagulation in the flow phantom is compared to the degree and rate of albumen coagulation when no fiber is present. The effect of the fiber device on the size of lesions formed in a heat-sensitive tissue-mimicking phantom is also investigated. Finally, finite difference time domain simulations are performed to determine the heat deposition in a tissue-mimicking phantom with a nylon disc embedded and a phantom with the nylon disc removed. The results of this study are quite promising for the possibility of increased efficacy of hemostasis for such a device in concert with HIFU in vessel-containing tissue volumes where HIFU alone is not completely effective.

  2. Early skeletal muscle hypertrophy and architectural changes in response to high-intensity resistance training.

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    Seynnes, O R; de Boer, M; Narici, M V

    2007-01-01

    The onset of whole muscle hypertrophy in response to overloading is poorly documented. The purpose of this study was to assess the early changes in muscle size and architecture during a 35-day high-intensity resistance training (RT) program. Seven young healthy volunteers performed bilateral leg extension three times per week on a gravity-independent flywheel ergometer. Cross-sectional area (CSA) in the central (C) and distal (D) regions of the quadriceps femoris (QF), muscle architecture, maximal voluntary contraction (MVC), and electromyographic (EMG) activity were measured before and after 10, 20, and 35 days of RT. By the end of the training period, MVC and EMG activity increased by 38.9 +/- 5.7 and 34.8% +/- 4.7%, respectively. Significant increase in QF CSA (3.5 and 5.2% in the C and D regions, respectively) was observed after 20 days of training, along with a 2.4 +/- 0.7% increase in fascicle length from the 10th day of training. By the end of the 35-day training period, the total increase in QF CSA for regions C and D was 6.5 +/- 1.1 and 7.4 +/- 0.8%, respectively, and fascicle length and pennation angle increased by 9.9 +/- 1.2 and 7.7 +/- 1.3%, respectively. The results show for the first time that changes in muscle size are detectable after only 3 wk of RT and that remodeling of muscle architecture precedes gains in muscle CSA. Muscle hypertrophy seems to contribute to strength gains earlier than previously reported; flywheel training seems particularly effective for inducing these early structural adaptations.

  3. Effect of vitamin E succinate on inflammatory cytokines induced by high-intensity interval training

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    Hadi Sarir

    2015-01-01

    Full Text Available Aim and Scope: The anti-inflammatory effect of vitamin E under moderate exercises has been evaluated. However, the effect of vitamin E succinate, which has more potent anti-inflammatory effect than other isomers of vitamin E has not been evaluated. Therefore, the aim of the present study was to evaluate the effects of vitamin E succinate on tumor necrosis factor alpha (TNF-a and interleukin-6 (IL-6 production induced by high-intensity interval training (HIIT. Materials and Methods: In the present study, 24 rats were randomly divided into control (C, supplementation (S, HIIT, and HIIT + supplementation (HIIT+S groups. HIIT training protocol on a treadmill (at a speed of 40-54 m/min and vitamin E succinate supplementation (60 mg/kg/day was conducted for 6 weeks. Results: Serum IL-6 in the HIIT group significantly increased compared with the C group (350.42 ± 123.31 pg/mL vs 158.60 ± 41.96 pg/mL; P = 0.002. Also, serum TNF-a concentrations significantly enhanced (718.15 ± 133.42 pg/mL vs 350.87 ± 64.93 pg/mL; P = 0.001 in the HIIT group compared with the C group. Treatment of the training group with vitamin E numerically reduced IL-6 and TNF-a when compared with the HIIT group (217.31 ± 29.21 and 510.23 ± 217.88, respectively, P > 0.05. However, no significant changes were observed in serum TNF-a (P = 0.31 and IL-6 (P = 0.52 concentrations in the HIIT + S group compared with the C group. Conclusion: HIIT-induced IL-6 and TNF-α decreased by administration of Vitamin E succinate.

  4. Cardioprotective Effect of High Intensity Interval Training and Nitric Oxide Metabolites (NO2-, NO3-

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    Aliasghar FALLAHI

    2015-10-01

    Full Text Available  Background: The aim of this study was to investigate the effects of High-Intensity Interval Training (HIIT on nitric oxide metabolites (NO2-, NO3- and myocardial infarct size after Ischemia/Reperfusion (I/R injury in healthy male rats.Methods: A total of 44 Wistar rats were randomly divided into 4 groups including HIIT (n=8, HIIT + IR protocol (n=14, control (n=8, and control + IR (n=14. Each training session of HIIT consisted of 1 hour of exercise in three stages: 6-minute running at 50-60% VO2max for warm-up; 7 intervals of 7-minute running on treadmill with a slope of 50 to 20° (4 minutes with an intensity of 80-100% VO2max and 3 minutes at 50-60% VO2max; and 5-minute running at 50-60% VO2max for cool-down. The control group did not participate in any exercise program. Nitric Oxide (NO and its metabolites were measured by using Griess reaction test.  Results: The results showed that eight weeks of exercise training exerted a significantly increasing effect on nitrite (8.55 µmol per liter, equivalent to 34.79%, nitrate (62.02 µmol per liter, equivalent to 149.48%, and NOx (66 µmol per liter, equivalent to 98.11% in the HIIT group compared with the control group. The results showed myocardial infract size (IS was significantly smaller (23.2%, P<0.001 in the exercise training group compared with the control group.Conclusion: Incremental changes in NO-NO3-, NO2- axis are one of mechanisms through which HIIT program can protect the heart from I/R injury and decrease myocardial infarction.   

  5. Lymphocyte enzymatic antioxidant responses to oxidative stress following high-intensity interval exercise.

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    Fisher, G; Schwartz, D D; Quindry, J; Barberio, M D; Foster, E B; Jones, K W; Pascoe, D D

    2011-03-01

    The purposes of this study were to 1) examine the immune and oxidative stress responses following high-intensity interval training (HIIT); 2) determine changes in antioxidant enzyme gene expression and enzyme activity in lymphocytes following HIIT; and 3) assess pre-HIIT, 3-h post-HIIT, and 24-h post-HIIT lymphocyte cell viability following hydrogen peroxide exposure in vitro. Eight recreationally active males completed three identical HIIT protocols. Blood samples were obtained at preexercise, immediately postexercise, 3 h postexercise, and 24 h postexercise. Total number of circulating leukocytes, lymphocytes, and neutrophils, as well as lymphocyte antioxidant enzyme activities, gene expression, cell viability (CV), and plasma thiobarbituric acid-reactive substance (TBARS) levels, were measured. Analytes were compared using a three (day) × four (time) ANOVA with repeated measures on both day and time. The a priori significance level for all analyses was P HIIT. No significant increases in lymphocyte SOD, CAT, or GPX gene expression were found. A significant increase in TBARS was found immediately post-HIIT on days 1 and 2. Lymphocyte CV in vitro significantly increased on days 2 and 3 compared with day 1. Additionally, there was a significant decrease in CV at 3 h compared with pre- and 24 h postexercise. These findings indicate lymphocytes respond to oxidative stress by increasing antioxidant enzyme activity. Additionally, HIIT causes oxidative stress but did not induce a significant postexercise lymphocytopenia. Analyses in vitro suggest that lymphocytes may become more resistant to subsequent episodes of oxidative stress. Furthermore, the analysis in vitro confirms that lymphocytes are more vulnerable to cytotoxic molecules during recovery from exercise.

  6. Preliminary safety analysis of high-intensity interval training (HIIT) in persons with chronic stroke.

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    Carl, Daniel L; Boyne, Pierce; Rockwell, Bradley; Gerson, Myron; Khoury, Jane; Kissela, Brett; Dunning, Kari

    2017-03-01

    The purpose of this study was to assess safety via electrocardiographic (ECG), blood pressure (BP), heart rate (HR), and orthopedic responses to 3 different high-intensity interval training (HIIT) protocols in persons with stroke. Eighteen participants (10 male; 61.9 + 8.3 years of age; 5.8 + 4.2 years poststroke) completed a symptom-limited graded exercise test (GXT) with ECG monitoring to screen for eligibility and determine HR peak. The 3 HIIT protocols involved repeated 30 s bursts of treadmill walking at maximum speed alternated with rest periods of 30 s (P30), 1 min (P60), or 2 min (P120). Sessions were performed in random order and included 5 min warm up, 20 min HIIT, and 5 min cool down. Variables measured included ECG activity, BP, HR, signs and symptoms of cardiovascular intolerance, and orthopedic concerns. Generalized linear mixed models and Tukey-Kramer adjustment were used to compare protocols using p HIIT session. HIIT elicited HRs in excess of 88% of measured HRpeak including 6 (P30), 8 (P60), and 2 (P120) participants eliciting a HR response above their GXT HRpeak. Both maximum BP and HR were significantly higher in P30 and P60 relative to P120. Preliminary data indicate that persons with chronic stroke who have been prescreened with an ECG stress test, a symptom-limited GXT, and a harness for fall protection may safely participate in HIIT, generating substantially higher HRs than what is seen in traditional moderate intensity training.

  7. Personalised Prescription of Scalable High Intensity Interval Training to Inactive Female Adults of Different Ages

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    Mair, Jacqueline L.

    2016-01-01

    Stepping is a convenient form of scalable high-intensity interval training (HIIT) that may lead to health benefits. However, the accurate personalised prescription of stepping is hampered by a lack of evidence on optimal stepping cadences and step heights for various populations. This study examined the acute physiological responses to stepping exercise at various heights and cadences in young (n = 14) and middle-aged (n = 14) females in order to develop an equation that facilitates prescription of stepping at targeted intensities. Participants completed a step test protocol consisting of randomised three-minute bouts at different step cadences (80, 90, 100, 110 steps·min-1) and step heights (17, 25, 30, 34 cm). Aerobic demand and heart rate values were measured throughout. Resting metabolic rate was measured in order to develop female specific metabolic equivalents (METs) for stepping. Results revealed significant differences between age groups for METs and heart rate reserve, and within-group differences for METs, heart rate, and metabolic cost, at different step heights and cadences. At a given step height and cadence, middle-aged females were required to work at an intensity on average 1.9 ± 0.26 METs greater than the younger females. A prescriptive equation was developed to assess energy cost in METs using multilevel regression analysis with factors of step height, step cadence and age. Considering recent evidence supporting accumulated bouts of HIIT exercise for health benefits, this equation, which allows HIIT to be personally prescribed to inactive and sedentary women, has potential impact as a public health exercise prescription tool. PMID:26848956

  8. Lymphocyte Redox Imbalance and Reduced Proliferation after a Single Session of High Intensity Interval Exercise.

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    Tossige-Gomes, Rosalina; Costa, Karine Beatriz; Ottone, Vinícius de Oliveira; Magalhães, Flávio de Castro; Amorim, Fabiano Trigueiro; Rocha-Vieira, Etel

    2016-01-01

    This study investigated whether an acute session of high-intensity interval training (HIIT) is sufficient to alter lymphocyte function and redox status. Sixteen young healthy men underwent a HIIT session on a cycloergometer, consisting of eight bouts of 1 min at 90-100% of peak power, with 75 seconds of active recovery at 30 W between bouts. Venous blood was collected before, immediately after, and 30 minutes after the HIIT session. In response to Staphylococcus aureus superantigen B (SEB) stimulation, lymphocyte proliferation decreased and the IL-2 concentration increased after the HIIT session. However, the HIIT session had no effect on lymphocyte proliferation or IL-2 response to phytohemagglutinin stimulation. The HIIT session also induced lymphocyte redox imbalance, characterized by an increase in the concentration of thiobarbituric acid reactive substances and a decrease in the activity of the antioxidant enzyme catalase. Lymphocyte viability was not affected by the HIIT session. The frequencies of CD25+ and CD69+ T helper and B lymphocytes in response to superantigen stimulation were lower after exercise, suggesting that superantigen-induced lymphocyte activation was reduced by HIIT. However, HIIT also led to a reduction in the frequency of CD4+ and CD19+ cells, so the frequencies of CD25+ and CD69+ cells within the CD4 and CD19 cell populations were not affected by HIIT. These data indicate that the reduced lymphocyte proliferation observed after HIIT is not due to reduced early lymphocyte activation by superantigen. Our findings show that an acute HIIT session promotes lymphocyte redox imbalance and reduces lymphocyte proliferation in response to superantigenic, but not to mitogenic stimulation. This observation cannot be explained by alteration of the early lymphocyte activation response to superantigen. The manner in which lymphocyte function modulation by an acute HIIT session can affect individual immunity and susceptibility to infection is important

  9. Acute Responses To Resistance And High Intensity Interval Training In Adolescents.

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    Harris, Nigel; Dulson, Deborah; Logan, Greig; Warbrick, Isaac; Merien, Fabrice; Lubans, David

    2016-08-16

    The purpose of this study was to compare the acute physiological responses within and between resistance training (RT) and high intensity interval training (HIIT) matched for time and with comparable effort, in a school setting. Seventeen early adolescents (12.9 ± 0.3 y) performed both RT (2-5 repetitions perceived short of failure at the end of each set) and HIIT (90% of age predicted maximum heart rate), equated for total work set and recovery period durations comprising of 12 'sets' of 30 s work followed by 30 s recovery (total session time 12 min). Variables of interest included oxygen consumption, set and session heart rate (HR) and rate of perceived exertion (RPE), and change in salivary cortisol (SC), salivary alpha amylase (SαA), and blood lactate (BL) from pre- to post-session. Analyses were conducted to determine responses within and between the two different protocols. For both RT and HIIT there were very large increases pre- to post-trial for SC and BL, and only BL increased greater in HIIT (9.1 ± 2.6 mmol·L) than RT (6.8 ± 3.3 mmol·L). Mean set HR for both RT (170 ± 9.1 bpm) and HIIT (179 ± 5.6 bpm) was at least 85% of HR maximum. VO2 over all 12 sets was greater for HIIT (33.8 ± 5.21 mL·kg·min) than RT (24.9 ± 3.23 mL·kg·min). Brief, repetitive, intermittent forays into high, but not supra-maximal intensity exercise utilising either RT or HIIT appeared to be a potent physiological stimulus in adolescents.

  10. High-intensity interval training induces a modest systemic inflammatory response in active, young men

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    Zwetsloot KA

    2014-01-01

    Full Text Available Kevin A Zwetsloot,1 Casey S John,1 Marcus M Lawrence,1 Rebecca A Battista,1 R Andrew Shanely1,2 1Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC, USA; 2Human Performance Laboratory, North Carolina Research Campus, Appalachian State University, Kannapolis, NC, USA Abstract: The purpose of this study was to determine: 1 the extent to which an acute session of high-intensity interval training (HIIT increases systemic inflammatory cytokines and chemokines, and 2 whether 2 weeks of HIIT training alters the inflammatory response. Eight recreationally active males (aged 22±2 years performed 2 weeks of HIIT on a cycle ergometer (six HIIT sessions at 8–12 intervals; 60-second intervals, 75-second active rest at a power output equivalent to 100% of their predetermined peak oxygen uptake (VO2max. Serum samples were collected during the first and sixth HIIT sessions at rest and immediately, 15, 30, and 45 minutes post-exercise. An acute session of HIIT induced significant increases in interleukin (IL-6, IL-8, IL-10, tumor necrosis factor-α, and monocyte chemotactic protein-1 compared with rest. The concentrations of interferon-γ, granulocyte macrophage-colony-stimulating factor, and IL-1β were unaltered with an acute session of HIIT. Two weeks of training did not alter the inflammatory response to an acute bout of HIIT exercise. Maximal power achieved during a VO2max test significantly increased 4.6%, despite no improvements in VO2max after 2 weeks of HIIT. These data suggest that HIIT exercise induces a small inflammatory response in young, recreationally active men; however, 2 weeks of HIIT does not alter this response. Keywords: cycle ergometer, inflammatory cytokines, exercise training

  11. High-Intensity Interval Training Elicits Higher Enjoyment than Moderate Intensity Continuous Exercise.

    Science.gov (United States)

    Thum, Jacob S; Parsons, Gregory; Whittle, Taylor; Astorino, Todd A

    2017-01-01

    Exercise adherence is affected by factors including perceptions of enjoyment, time availability, and intrinsic motivation. Approximately 50% of individuals withdraw from an exercise program within the first 6 mo of initiation, citing lack of time as a main influence. Time efficient exercise such as high intensity interval training (HIIT) may provide an alternative to moderate intensity continuous exercise (MICT) to elicit substantial health benefits. This study examined differences in enjoyment, affect, and perceived exertion between MICT and HIIT. Twelve recreationally active men and women (age = 29.5 ± 10.7 yr, VO2max = 41.4 ± 4.1 mL/kg/min, BMI = 23.1 ± 2.1 kg/m2) initially performed a VO2max test on a cycle ergometer to determine appropriate workloads for subsequent exercise bouts. Each subject returned for two additional exercise trials, performing either HIIT (eight 1 min bouts of cycling at 85% maximal workload (Wmax) with 1 min of active recovery between bouts) or MICT (20 min of cycling at 45% Wmax) in randomized order. During exercise, rating of perceived exertion (RPE), affect, and blood lactate concentration (BLa) were measured. Additionally, the Physical Activity Enjoyment Scale (PACES) was completed after exercise. Results showed higher enjoyment (p = 0.013) in response to HIIT (103.8 ± 9.4) versus MICT (84.2 ± 19.1). Eleven of 12 participants (92%) preferred HIIT to MICT. However, affect was lower (pHIIT versus MICT. Although HIIT is more physically demanding than MICT, individuals report greater enjoyment due to its time efficiency and constantly changing stimulus.

  12. Modelling the temperature evolution of bone under high intensity focused ultrasound.

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    ten Eikelder, H M M; Bošnački, D; Elevelt, A; Donato, K; Di Tullio, A; Breuer, B J T; van Wijk, J H; van Dijk, E V M; Modena, D; Yeo, S Y; Grüll, H

    2016-02-21

    Magnetic resonance-guided high intensity focused ultrasound (MR-HIFU) has been clinically shown to be effective for palliative pain management in patients suffering from skeletal metastasis. The underlying mechanism is supposed to be periosteal denervation caused by ablative temperatures reached through ultrasound heating of the cortex. The challenge is exact temperature control during sonication as MR-based thermometry approaches for bone tissue are currently not available. Thus, in contrast to the MR-HIFU ablation of soft tissue, a thermometry feedback to the HIFU is lacking, and the treatment of bone metastasis is entirely based on temperature information acquired in the soft tissue adjacent to the bone surface. However, heating of the adjacent tissue depends on the exact sonication protocol and requires extensive modelling to estimate the actual temperature of the cortex. Here we develop a computational model to calculate the spatial temperature evolution in bone and the adjacent tissue during sonication. First, a ray-tracing technique is used to compute the heat production in each spatial point serving as a source term for the second part, where the actual temperature is calculated as a function of space and time by solving the Pennes bio-heat equation. Importantly, our model includes shear waves that arise at the bone interface as well as all geometrical considerations of transducer and bone geometry. The model was compared with a theoretical approach based on the far field approximation and an MR-HIFU experiment using a bone phantom. Furthermore, we investigated the contribution of shear waves to the heat production and resulting temperatures in bone. The temperature evolution predicted by our model was in accordance with the far field approximation and agreed well with the experimental data obtained in phantoms. Our model allows the simulation of the HIFU treatments of bone metastasis in patients and can be extended to a planning tool prior to MR

  13. Endurance and sprint benefits of high-intensity and supramaximal interval training.

    Science.gov (United States)

    Cicioni-Kolsky, Daniel; Lorenzen, Christian; Williams, Morgan David; Kemp, Justin Guy

    2013-01-01

    This study examined the effect of two different interval training programs-high-intensity interval training (HIT) and supramaximal interval training (SMIT)-on measures of sprint and endurance performance. Physically active individuals (Females: n=32; age 19.3, s=2.2 years; mass 67.6, s=9.1 kg; stature 172.7, s=6.6 cm. Males: n=23; age 20.0, s=2.7 years; mass 71.3, s=8.3 kg; stature 176.6, s=5.8 cm) completed pre-testing that comprised (1) 3000 m time-trial, (2) 40 m sprint, and (3) repeated sprint ability (RSA-6×40 m sprints, 24 s active recovery) performance. Participants were then matched for average 3000 m running velocity (AV) and randomly assigned to one of three groups: (i) HIT, n=19, 4 min at 100% AV, 4 min passive recovery, 4-6 bouts per session; (ii) SMIT, n=20, 30 s at 130% AV, 150 s passive recovery, 7-12 bouts per session; and (iii) control group, n=16, 30 min continuous running at 75% AV. Groups trained three times per week for six weeks. When time to complete each test were compared among groups: (i) improvements in 3000 m time trial performance were greater following SMIT than continuous running, and (ii) improvements in 40 m sprint and RSA performance were greater following SMIT than HIT and continuous running. In addition, a gender effect was observed for the 3000 m time trial only, where females changed more following the training intervention than males. In summary, for concurrent improvements in endurance, sprint and repeated sprint performance, SMIT provides the greatest benefits for physically active individuals.

  14. Similar health benefits of endurance and high-intensity interval training in obese children.

    Directory of Open Access Journals (Sweden)

    Ana Carolina Corte de Araujo

    Full Text Available PURPOSE: To compare two modalities of exercise training (i.e., Endurance Training [ET] and High-Intensity Interval Training [HIT] on health-related parameters in obese children aged between 8 and 12 years. METHODS: Thirty obese children were randomly allocated into either the ET or HIT group. The ET group performed a 30 to 60-minute continuous exercise at 80% of the peak heart rate (HR. The HIT group training performed 3 to 6 sets of 60-s sprint at 100% of the peak velocity interspersed by a 3-min active recovery period at 50% of the exercise velocity. HIT sessions last ~70% less than ET sessions. At baseline and after 12 weeks of intervention, aerobic fitness, body composition and metabolic parameters were assessed. RESULTS: BOTH THE ABSOLUTE (ET: 26.0%; HIT: 19.0% and the relative VO(2 peak (ET: 13.1%; HIT: 14.6% were significantly increased in both groups after the intervention. Additionally, the total time of exercise (ET: 19.5%; HIT: 16.4% and the peak velocity during the maximal graded cardiorespiratory test (ET: 16.9%; HIT: 13.4% were significantly improved across interventions. Insulinemia (ET: 29.4%; HIT: 30.5% and HOMA-index (ET: 42.8%; HIT: 37.0% were significantly lower for both groups at POST when compared to PRE. Body mass was significantly reduced in the HIT (2.6%, but not in the ET group (1.2%. A significant reduction in BMI was observed for both groups after the intervention (ET: 3.0%; HIT: 5.0%. The responsiveness analysis revealed a very similar pattern of the most responsive variables among groups. CONCLUSION: HIT and ET were equally effective in improving important health related parameters in obese youth.

  15. Crossfit-based high-intensity power training improves maximal aerobic fitness and body composition.

    Science.gov (United States)

    Smith, Michael M; Sommer, Allan J; Starkoff, Brooke E; Devor, Steven T

    2013-11-01

    The purpose of this study was to examine the effects of a crossfit-based high-intensity power training (HIPT) program on aerobic fitness and body composition. Healthy subjects of both genders (23 men, 20 women) spanning all levels of aerobic fitness and body composition completed 10 weeks of HIPT consisting of lifts such as the squat, deadlift, clean, snatch, and overhead press performed as quickly as possible. Additionally, this crossfit-based HIPT program included skill work for the improvement of traditional Olympic lifts and selected gymnastic exercises. Body fat percentage was estimated using whole-body plethysmography, and maximal aerobic capacity (VO2max) was measured by analyzing expired gasses during a Bruce protocol maximal graded treadmill test. These variables were measured again after 10 weeks of training and compared for significant changes using a paired t-test. Results showed significant (p < 0.05) improvements of VO2max in men (43.10 ± 1.40 to 48.96 ± 1.42 ml · kg · min) and women (35.98 ± 1.60 to 40.22 ± 1.62 ml · kg · min) and decreased body fat percentage in men (22.2 ± 1.3 to 18.0 ± 1.3) and women (26.6 ± 2.0 to 23.2 ± 2.0). These improvements were significant across all levels of initial fitness. Significant correlations between absolute oxygen consumption and oxygen consumption relative to body weight was found in both men (r = 0.83, p < 0.001) and women (r = 0.94, p < 0.001), indicating that HIPT improved VO2max scaled to body weight independent of changes to body composition. Our data show that HIPT significantly improves VO2max and body composition in subjects of both genders across all levels of fitness.

  16. Cardiac autonomic response following high-intensity running work-to-rest interval manipulation.

    Science.gov (United States)

    Cipryan, Lukas; Laursen, Paul B; Plews, Daniel J

    2016-10-01

    The cardiorespiratory, cardiac autonomic (via heart rate variability (HRV)) and plasma volume responses to varying sequences of high-intensity interval training (HIT) of consistent external work were investigated. Twelve moderately trained males underwent three HIT bouts and one control session. The HIT trials consisted of warm-up, followed by 12 min of 15 s, 30 s or 60 s work:relief HIT sequences at an exercise intensity of 100% of the individual velocity at [Formula: see text]O2max (v[Formula: see text]O2max), interspersed by relief intervals at 60% [Formula: see text]O2max (work/relief ratio = 1). HRV was evaluated via the square root of the mean sum of the squared differences between R-R intervals (rMSSD) before, 1 h, 3 h and 24 h after the exercise. Plasma volume was assessed before, immediately after, and 3 h and 24 h after. There were no substantial between-trial differences in acute cardiorespiratory responses. The rMSSD values remained decreased 1 h after the exercise cessation in all exercise groups. The rMSSD subsequently increased between 1 h and 3 h after exercise, with the most pronounced change in the 15/15 group. There were no relationships between HRV and plasma volume. All HIT protocols resulted in similar cardiorespiratory responses with slightly varying post-exercise HRV responses, with the 30/30 protocol eliciting the least disruption to post-exercise HRV. These post-exercise HRV findings suggest that the 30/30 sequence may be the preferable HIT prescription when the between-training period is limited.

  17. Accelerating Value Creation with Accelerators

    DEFF Research Database (Denmark)

    Jonsson, Eythor Ivar

    2015-01-01

    Accelerators can help to accelerate value creation. Accelerators are short-term programs that have the objective of creating innovative and fast growing ventures. They have gained attraction as larger corporations like Microsoft, Barclays bank and Nordea bank have initiated and sponsored accelera......Accelerators can help to accelerate value creation. Accelerators are short-term programs that have the objective of creating innovative and fast growing ventures. They have gained attraction as larger corporations like Microsoft, Barclays bank and Nordea bank have initiated and sponsored...... an approach to facilitate implementation and realization of business ideas and is a lucrative approach to transform research into ventures and to revitalize regions and industries in transition. Investors have noticed that the accelerator approach is a way to increase the possibility of success by funnelling...

  18. Temp erature-dep endent of Nonlinear Optical Conductance of Graphene-based Systems in High-intensity Terahertz Field

    Institute of Scientific and Technical Information of China (English)

    Jing Lv; Rui-yang Yuan; Hui Yan

    2014-01-01

    For multi-photon processed with the linear dispersion in the high-intensity terahertz (THz) field, we have systematically investigated the temperature-dependent nonlinear optical response of graphene-based systems, including single layer graphene, graphene superlattice and gapped graphene. In the intrinsic single layer graphene system, it demonstrates that, at low temperature, nonlinear optical conductivities of the third-and fifth-order are respectively five and ten orders of magnitude larger than the universal conductivity with high-intensity and low frequency THz wave.In the graphene superlattice and gapped graphene systems, the optical responses enhanced because of the anisotropic massless and massive Dirac fermions.

  19. Effect of 8 Weeks of High Intensity Interval Training on Plasma Levels of Adiponectin and Leptin in Overweight Nurses

    OpenAIRE

    Sahar Avazpor; Jamal Fazel Kalkhoran; Hojat Allah Amini

    2016-01-01

    Background: High intensity interval training (HIIT) is a novel training method which has received most attention in recent years. The aim of this study was to examine the effect of 8 weeks of high intensity interval training (HIIT) on plasma levels of adiponectin and leptin in overweight nurses.Materials and Methods: 27 nurses (mean age 25.81±60 years, height 158.01±67 cm and weight 69.41±25 kg) were voluntarily selected and randomly assigned to three groups (each group 9 subjects): 1. HIIT (...

  20. A forced running wheel system with a microcontroller that provides high-intensity exercise training in an animal ischemic stroke model.

    Science.gov (United States)

    Chen, C C; Chang, M W; Chang, C P; Chan, S C; Chang, W Y; Yang, C L; Lin, M T

    2014-10-01

    We developed a forced non-electric-shock running wheel (FNESRW) system that provides rats with high-intensity exercise training using automatic exercise training patterns that are controlled by a microcontroller. The proposed system successfully makes a breakthrough in the traditional motorized running wheel to allow rats to perform high-intensity training and to enable comparisons with the treadmill at the same exercise intensity without any electric shock. A polyvinyl chloride runway with a rough rubber surface was coated on the periphery of the wheel so as to permit automatic acceleration training, and which allowed the rats to run consistently at high speeds (30 m/min for 1 h). An animal ischemic stroke model was used to validate the proposed system. FNESRW, treadmill, control, and sham groups were studied. The FNESRW and treadmill groups underwent 3 weeks of endurance running training. After 3 weeks, the experiments of middle cerebral artery occlusion, the modified neurological severity score (mNSS), an inclined plane test, and triphenyltetrazolium chloride were performed to evaluate the effectiveness of the proposed platform. The proposed platform showed that enhancement of motor function, mNSS, and infarct volumes was significantly stronger in the FNESRW group than the control group (P<0.05) and similar to the treadmill group. The experimental data demonstrated that the proposed platform can be applied to test the benefit of exercise-preconditioning-induced neuroprotection using the animal stroke model. Additional advantages of the FNESRW system include stand-alone capability, independence of subjective human adjustment, and ease of use.